NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21

                                                    FINAL#2,  2 YEAR CHRONIC

       Facility:  Battelle Northwest

       Chemical CAS #:  22398-80-7

       Lock Date:  10/02/98

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All

                                                              Page   1

NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 9|             
                                           | 7| 7| 6| 7| 6| 7| 7| 4| 6| 7| 6| 6| 6| 5| 4| 5| 6| 5| 7| 7| 6| 5| 7| 6| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A|             
      Inflammation, Suppurative            |       1                                                        1         |             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A|             
      Peyer's Patch, Hyperplasia           |                                        2                                 |             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A|             
      Epithelium, Hyperplasia              |                                                                          |             
      Peyer's Patch, Hyperplasia           |                                                                          |             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                X         |             
      Clear Cell Focus                     |             X                                               X            |             
      Eosinophilic Focus                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                                           1                              |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Karyomegaly                          |                                                                          |             
      Necrosis                             |                            1                 1                           |             
      Tension Lipidosis                    |                                     X                                    |             
      Vacuolization Cytoplasmic            |                                              1                           |             
      Bile Duct, Cyst                      |                                     2                                    |             

                                            __________________________________________________________________________|             
   Mesentery                               |       +  +                 +           +              +           +  +  +|             
      Angiectasis                          |                                                                         3|             
      Fat, Necrosis                        |       2  2                             2              4              4   |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                    1                     |             

                                            __________________________________________________________________________|             
   Tooth                                   |                                                                      +   |             
      Malformation                         |                                                                      X   |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1  1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  2  1  1  1  1  1   |             
      Artery, Inflammation                 |                                                                         1|             
      Atrium, Thrombosis                   |                                                                         2|             
      Epicardium, Inflammation             |                                                                          |             
      Valve, Thrombosis                    |                                                                         4|             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 9|             
                                           | 7| 7| 6| 7| 6| 7| 7| 4| 6| 7| 6| 6| 6| 5| 4| 5| 6| 5| 7| 7| 6| 5| 7| 6| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Degeneration, Cystic                 |                                  2                                       |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hypertrophy                          |       1  1        1              1                                       |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               1                                          |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           2                              |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  M  +  M  +  +  +  M  +  +  +  +  +  +  M  +|             
      Hyperplasia                          |                      2                                                   |             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |       4     1     1           1     1                       2            |             
      Pars Intermedia, Hyperplasia         | 2                                                                        |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                         3                                                |             
      Follicular Cell, Hyperplasia         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  M  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  M  +  +|             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                 4                        |             
      Cyst                                 | 1        3  2     3                                2     1               |             
      Interstitial Cell, Hyperplasia       |                                                                          |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hydrometra                           |       2  2                 4  2           3        2                     |             
      Hyperplasia, Cystic                  |    2  2     2  2  4     1     2  3  1  4     3        2  2  2  2  2  2   |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hyperplasia                          |                            2                                             |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  M  +  +  M  M  M  +  +  +  M  +  +  +  M  +  +  +  +  M  +  +  +|             
      Hyperplasia                          |                            1                       1                     |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  M  +  +  +  +  +  +  +  M  M  +  +  +  M  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                                                    2                     |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 9|             
                                           | 7| 7| 6| 7| 6| 7| 7| 4| 6| 7| 6| 6| 6| 5| 4| 5| 6| 5| 7| 7| 6| 5| 7| 6| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  M  M  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                    2              2      |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                   1  1  1                          2              1  1  2|             
      Hyperplasia, Lymphoid                |                         2           2  2           2  3        2     2   |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |    2     1  1     3        2                                   1         |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Mononuclear Cell                |                                                                          |             

                                            __________________________________________________________________________|             
   Spinal Cord                             |                            +                                             |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Epithelium, Hyperplasia     |                         1                          1        1  1         |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                   1        1        1           1                        |             
      Inflammation, Chronic Active         |                            2                                             |             
      Mediastinum, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Mononuclear Cell                |                                                                          |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Inflammation, Suppurative            |          1                                                           1  1|             
      Olfactory Epithelium, Atrophy        |                                        1     1                       2   |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |                                                       1                  |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |                1  1     1  1        1  2     1     1  2        1     2  2|             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 9|             
                                           | 7| 7| 6| 7| 6| 7| 7| 4| 6| 7| 6| 6| 6| 5| 4| 5| 6| 5| 7| 7| 6| 5| 7| 6| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                                                    1                     |             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Harderian Gland                         |                                  +                    +                  |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                         1|             
      Metaplasia, Osseous                  |                1                             1                           |             
      Nephropathy                          |    1  2  1  1     1  3  1  1     1  1  1  1  1  1  1  1  1  1  1     1   |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                    1                     |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3|            |
                                           | 7| 7| 6| 6| 5| 6| 7| 6| 6| 6| 5| 9| 6| 6| 6| 7| 5| 5| 6| 7| 8| 6| 5| 7| 6|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Inflammation, Suppurative            |                                                                          |      2  1.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Peyer's Patch, Hyperplasia           |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Epithelium, Hyperplasia              |                                     2                                    |      1  2.0|
      Peyer's Patch, Hyperplasia           |                                        2              2                  |      2  2.0|

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                              X                           |      2     |
      Clear Cell Focus                     |                                                                          |      2     |
      Eosinophilic Focus                   |                X        X        X                          X  X     X   |      6     |
      Hematopoietic Cell Proliferation     |                            3                                1            |      3  1.7|
      Hyperplasia, Lymphoid                | 2                                                                        |      1  2.0|
      Karyomegaly                          |                                        1                                 |      1  1.0|
      Necrosis                             |                            1                                1            |      4  1.0|
      Tension Lipidosis                    |                                                    X                     |      2     |
      Vacuolization Cytoplasmic            |                                                                          |      1  1.0|
      Bile Duct, Cyst                      |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               | +                    +     +        +                 +                  |  13        |
      Angiectasis                          |                                                                          |      1  3.0|
      Fat, Necrosis                        | 2                    3     3        2                 2                  |     10  2.6|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                      2   |      1  2.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Hyperplasia              |                               1                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                2                                                         |      2  1.5|

                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Malformation                         |                                                                          |      1     |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  1     1  1  1  1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1  1|     45  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3|            |
                                           | 7| 7| 6| 6| 5| 6| 7| 6| 6| 6| 5| 9| 6| 6| 6| 7| 5| 5| 6| 7| 8| 6| 5| 7| 6|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Artery, Inflammation                 |                                                                          |      1  1.0|
      Atrium, Thrombosis                   |                                                                          |      1  2.0|
      Epicardium, Inflammation             |                                  2                                       |      1  2.0|
      Valve, Thrombosis                    |                                                                          |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   |                                                          2  2            |      2  2.0|
      Degeneration, Cystic                 |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                             1            |      1  1.0|
      Hypertrophy                          |                1     1     1                 1     1                     |      9  1.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                              2                 1  1      |      4  1.3|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                  3                                       |      2  2.5|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  +  M  +  +  +  +  M  +  +  M  M  +  M  M  M  +  +  +  M  +  +  +  M|  34        |
      Hyperplasia                          |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Hyperplasia           | 2           2        3  2           3     4        1        2  1  2      |     16  2.0|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicle, Cyst                       |                                                                          |      1  3.0|
      Follicular Cell, Hyperplasia         |                                                                         2|      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  45        |

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +|  47        |
      Angiectasis                          |    2                                                                     |      2  3.0|
      Cyst                                 |                            2  1                    2     2     4        2|     12  2.1|
      Interstitial Cell, Hyperplasia       |          2                                                               |      1  2.0|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                   1      |      1  1.0|
      Hydrometra                           |       2                 3                                                |      8  2.5|
      Hyperplasia, Cystic                  | 4  3     2  3  2  1  2     2  2     2  2  2  2  2  2  2  3  3  4     1  3|     38  2.3|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3|            |
                                           | 7| 7| 6| 6| 5| 6| 7| 6| 6| 6| 5| 9| 6| 6| 6| 7| 5| 5| 6| 7| 8| 6| 5| 7| 6|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                         1  1                                             |      2  1.0|
      Hyperplasia                          |                2     2     3        2                       3            |      6  2.3|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +                                                         |   1        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  +  +  M  +  +  +  M  +  +  +  M  M  +  +  +  +  +  +  M  +  +  +|  36        |
      Hyperplasia                          |          2                                   2                          3|      5  1.8|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  M  +  M  M  +  +  M  M  M  +  +  +  M  M  +  +  +|  36        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hematopoietic Cell Proliferation     |                                                             2            |      1  2.0|
      Hyperplasia                          |          2        2                          2           2  2  1     2   |      8  1.9|
      Inflammation, Chronic Active         |                            3                                             |      1  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +|  42        |
      Hyperplasia                          |                                                                          |      2  2.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                   1  1  1  3  1     1        2              3     3      |     16  1.6|
      Hyperplasia, Lymphoid                |                   2           2              4  2  2     2           2  2|     15  2.2|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  47        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                            2                 2                           |      2  2.0|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                            3                                             |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |          2        1     1                 1        1                     |     11  1.5|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Mononuclear Cell                |                      1                       2                           |      2  1.5|

                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Squamous Epithelium, Hyperplasia     |    2     1                    1                                   1     1|      9  1.1|

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3|            |
                                           | 7| 7| 6| 6| 5| 6| 7| 6| 6| 6| 5| 9| 6| 6| 6| 7| 5| 5| 6| 7| 8| 6| 5| 7| 6|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                                                                          |      4  1.0|
      Inflammation, Chronic Active         |                            3                                             |      2  2.5|
      Mediastinum, Inflammation, Chronic   |                                                                          |            |
          Active                           |                            3                                             |      1  3.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Mononuclear Cell                |                                        2                                 |      1  2.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                       1                  |      1  1.0|
      Inflammation, Suppurative            | 1     2  1                                            1                  |      7  1.1|
      Olfactory Epithelium, Atrophy        |                         1                    1           1               |      6  1.2|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |          2                                                        1      |      3  1.3|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         | 1  1  2  2        1     1     1     1  1     1     1  1  1     1  1  1   |     28  1.2|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +                                                                        |   3        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Metaplasia, Osseous                  |                                                                          |      2  1.0|
      Nephropathy                          |                1     1  1  1  1     1  1  1  1  1  1  1  1     1  1  1  1|     37  1.1|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |                                                                   1      |      2  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 4| 7| 7| 6| 6| 5| 7| 7| 7| 6| 4| 6| 6| 6| 6| 7| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 2| 5| 3| 8| 1| 3| 1| 5| 8| 0| 3| 3| 8| 2| 8| 7| 4| 7| 3| 3| 3| 3| 8| 8|             
                                           | 7| 7| 9| 7| 9| 5| 2| 7| 3| 9| 0| 5| 5| 7| 6| 8| 4| 5| 4| 7| 6| 6| 5| 8| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.03                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Hyaline                |                                                                      1   |             
      Inflammation, Suppurative            |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                          |             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Eosinophilic Focus                   |          X                                      X  X                     |             
      Eosinophilic Focus, Multiple         |                               X                       X     X            |             
      Hematopoietic Cell Proliferation     |                                           1                              |             
      Inflammation                         |                                                                          |             
      Necrosis                             |                                              1                           |             
      Tension Lipidosis                    |                                                                         X|             

                                            __________________________________________________________________________|             
   Mesentery                               |                      +                          +              +  +      |             
      Artery, Inflammation                 |                      3                                                   |             
      Fat, Necrosis                        |                                                                2  2      |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |    2                                                                    2|             
      Epithelium, Hyperplasia              |    3                                                                    2|             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  1  1     1  1  1        1  1  1  1     1  1  1  1  1  1  2  1  1   |             
      Artery, Inflammation                 |    1  2                       2           2        1                 2   |             
      Atrium, Thrombosis                   |                                                                          |             
      Epicardium, Inflammation             |                                              3                           |             
      Pericardium, Inflammation            |       1                                            2     2               |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                         1                                                |             
      Hypertrophy                          | 1                             1  2  1                          1         |             
      Capsule, Hyperplasia                 |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               1  1                                       |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 4| 7| 7| 6| 6| 5| 7| 7| 7| 6| 4| 6| 6| 6| 6| 7| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 2| 5| 3| 8| 1| 3| 1| 5| 8| 0| 3| 3| 8| 2| 8| 7| 4| 7| 3| 3| 3| 3| 8| 8|             
                                           | 7| 7| 9| 7| 9| 5| 2| 7| 3| 9| 0| 5| 5| 7| 6| 8| 4| 5| 4| 7| 6| 6| 5| 8| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.03                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  I  +  M  +  M  +  +  M  M  +  +  +  +  +  M  +  +  M  +  M  M  +  M|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           | 3              3           1  2  1  1  2                 2     2         |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                     1                                    |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Peritoneum                              |                                                 +                        |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          2                                1                              |             
      Cyst                                 |    1                    2           3                       2            |             
      Thrombosis                           |                                                                          |             
      Interstitial Cell, Hyperplasia       |                   2                                                      |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    1  2                                         2                        |             
      Hydrometra                           |                            3     3                          4  4     4   |             
      Hyperplasia, Cystic                  | 2  2  2  2     2  2        2  2     2     2  2        2  2  2  2  2     2|             
      Inflammation, Suppurative            |    2                                                                     |             
      Mineralization                       |       2                                                                  |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  2     2  1                 1           1  2  3              2         |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                   +                                      +  +  +         |             
      Iliac, Angiectasis                   |                                                          2               |             
      Iliac, Hyperplasia                   |                                                             2            |             
      Lumbar, Hyperplasia                  |                                                                2         |             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         | 1  1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Hyperplasia                          | 3  3  2  3     4     4  2  2  3  3  4  3  3  2  2  2  2  4  2  4  3     2|             
      Artery, Inflammation                 |                                                                   2      |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  +  M  M  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  M  +  M  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                2        2              2                                 |             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |       1                 1     1        1  1     1     1     1  1         |             
      Hyperplasia                          |    4  2  3     4     4  2  2  3  2  4  3  4     3  2  2  2  2  4  3  3  2|             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 1  2  2  2        3  1  3  3  2  2  2     2  2  2  2  3     2  2  1  3   |             
      Hyperplasia, Lymphoid                |                                     2                                    |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 4| 7| 7| 6| 6| 5| 7| 7| 7| 6| 4| 6| 6| 6| 6| 7| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 2| 5| 3| 8| 1| 3| 1| 5| 8| 0| 3| 3| 8| 2| 8| 7| 4| 7| 3| 3| 3| 3| 8| 8|             
                                           | 7| 7| 9| 7| 9| 5| 2| 7| 3| 9| 0| 5| 5| 7| 6| 8| 4| 5| 4| 7| 6| 6| 5| 8| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.03                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                2                 2  2                                    |             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                       2                  |             
      Metaplasia, Squamous                 |                                                    1                     |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Subcutaneous Tissue, Angiectasis     |       2                                                                  |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                3                                                         |             
      Fibrous Osteodystrophy               | 1  1     1     2              1     2        1              1  3         |             
      Inflammation, Chronic                |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Mononuclear Cell                |                                                                   3      |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                  1                                       |             
      Squamous Epithelium, Hyperplasia     |    1     1  1     2        1  1  1        1                             2|             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         | X  X  X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X  X  X  X  X  X|             
      Hemorrhage                           | 1                          1                                             |             
      Inflammation, Chronic Active         | 3  4  3  3  2  3  2  3  3  3  3  3  3  2  4  3  3  3  3  2  2  3  3  3  2|             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Alveolus, Proteinosis                | 1        1     1  1           1  1  1  1     1     1  1  1  1  1  1  1   |             
      Artery, Inflammation                 |                                                                          |             
      Interstitium, Fibrosis               |    1                                                                     |             
      Serosa, Fibrosis                     | 4  4  3  4  3  4  3  4  4  4  4  4  4  4  4  4  4  4  4  4  3  4  3  4  3|             
      Serosa, Metaplasia, Osseous          |                                                          1               |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 1  1           2                                                  1      |             
      Olfactory Epithelium, Atrophy        |                                                                          |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 4| 7| 7| 6| 6| 5| 7| 7| 7| 6| 4| 6| 6| 6| 6| 7| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 2| 5| 3| 8| 1| 3| 1| 5| 8| 0| 3| 3| 8| 2| 8| 7| 4| 7| 3| 3| 3| 3| 8| 8|             
                                           | 7| 7| 9| 7| 9| 5| 2| 7| 3| 9| 0| 5| 5| 7| 6| 8| 4| 5| 4| 7| 6| 6| 5| 8| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.03                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Hyaline                         |                               1                                          |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |       1        1           1  2        1           1        1  1     1   |             

                                            __________________________________________________________________________|             
   Pleura                                  |    +           +              +        +           +           +         |             
      Mesothelium, Hyperplasia             |    1           2              1        1           4           1         |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  A  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Osseous                  |                                                             2            |             
      Nephropathy                          | 1     1  1     1  1  1        1        1     1  1  1        1  1  1  2   |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                 2                        |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 5| 6| 7| 6| 6| 5| 5| 6| 6| 6| 6| 5| 5| 6| 7| 7| 7| 5| 7| 5| 6| 6|            |
                             DAY ON TEST   | 1| 3| 8| 3| 5| 3| 8| 4| 8| 3| 1| 8| 8| 4| 3| 3| 7| 3| 3| 0| 1| 3| 4| 4| 3|            |
                                           | 4| 7| 7| 3| 7| 5| 8| 5| 9| 3| 7| 6| 6| 5| 3| 3| 1| 6| 6| 6| 4| 7| 8| 5| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0.03                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  45        |
      Degeneration, Hyaline                |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                   1                                               1      |      2  1.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Epithelium, Hyperplasia              |                               2                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                      X                             X                     |      2     |
      Eosinophilic Focus                   |                   X                                                     X|      5     |
      Eosinophilic Focus, Multiple         |                                     X                                    |      4     |
      Hematopoietic Cell Proliferation     |          4              1                                                |      3  2.0|
      Inflammation                         |    2                                                                     |      1  2.0|
      Necrosis                             |             1     1                                                      |      3  1.0|
      Tension Lipidosis                    |                                                                          |      1     |

                                            __________________________________________________________________________|____________|
   Mesentery                               |                         +           +                    +  +            |   8        |
      Artery, Inflammation                 |                         4                                3  1            |      4  2.8|
      Fat, Necrosis                        |                                     3                                    |      3  2.3|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ulcer                                |                                                                          |      2  2.0|
      Epithelium, Hyperplasia              |                                           1  2                           |      4  2.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  1  1  1     1  1  2     1     1  1  1  1  1     1  1  1     1  1     1|     39  1.1|
      Artery, Inflammation                 |       2  1     2        4  1        3           1  2     1  2            |     16  1.8|
      Atrium, Thrombosis                   |                                     3                                    |      1  3.0|
      Epicardium, Inflammation             |          1     2           2  2                                          |      5  2.0|
      Pericardium, Inflammation            |             1     3        3                             2        2  2   |      9  2.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 5| 6| 7| 6| 6| 5| 5| 6| 6| 6| 6| 5| 5| 6| 7| 7| 7| 5| 7| 5| 6| 6|            |
                             DAY ON TEST   | 1| 3| 8| 3| 5| 3| 8| 4| 8| 3| 1| 8| 8| 4| 3| 3| 7| 3| 3| 0| 1| 3| 4| 4| 3|            |
                                           | 4| 7| 7| 3| 7| 5| 8| 5| 9| 3| 7| 6| 6| 5| 3| 3| 1| 6| 6| 6| 4| 7| 8| 5| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0.03                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Amyloid Deposition                   |                                                                          |      1  1.0|
      Hypertrophy                          |       2                                                        1         |      7  1.3|
      Capsule, Hyperplasia                 |                                                       4                  |      1  4.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                2                                         2     2         |      5  1.6|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  M  +  +  +  +  M  +  M  +  M  +  M  M  M  +  +  M  +  +  +|  31        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Hyperplasia           |    2              2     1     1                    2  3                  |     15  1.9|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                   1                                                      |      2  1.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  M  +  +  +  +  M  +  M  +  +  M  M  +  +  +  +  +  +  M  M  +  +  +|  40        |

                                            __________________________________________________________________________|____________|
   Ovary                                   | M  +  M  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Angiectasis                          |                                                                          |      2  1.5|
      Cyst                                 |          2     1  2                                                  3  2|      9  2.0|
      Thrombosis                           |                                                                      3   |      1  3.0|
      Interstitial Cell, Hyperplasia       |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      3  1.7|
      Hydrometra                           |                1     3                          2                        |      8  3.0|
      Hyperplasia, Cystic                  | 1  1  1           3     2  2        4     1        2  2  1     1  2  2   |     31  1.9|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          2                    2                    2        3            |     13  1.9|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                +         |   5        |
      Iliac, Angiectasis                   |                                                                          |      1  2.0|
      Iliac, Hyperplasia                   |                                                                          |      1  2.0|
      Lumbar, Hyperplasia                  |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         | 1  1  1  1     1  1  1  1  1     1     1  1  1  1  1     1  1     1  1  1|     44  1.0|
      Hyperplasia                          | 4  2  4        2  3  2  3  4     2     4  3  3  3  2  4  3  3     2  2  2|     42  2.8|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 5| 6| 7| 6| 6| 5| 5| 6| 6| 6| 6| 5| 5| 6| 7| 7| 7| 5| 7| 5| 6| 6|            |
                             DAY ON TEST   | 1| 3| 8| 3| 5| 3| 8| 4| 8| 3| 1| 8| 8| 4| 3| 3| 7| 3| 3| 0| 1| 3| 4| 4| 3|            |
                                           | 4| 7| 7| 3| 7| 5| 8| 5| 9| 3| 7| 6| 6| 5| 3| 3| 1| 6| 6| 6| 4| 7| 8| 5| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0.03                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Artery, Inflammation                 |                         3                                                |      2  2.5|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  M  M  M  +  +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +  +|  36        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |       2           4           4                                          |      6  2.7|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Foreign Body                         | 1                    1  1           1     1  1  1     1  1  1        1   |     20  1.0|
      Hyperplasia                          | 4     4        3  4  2  2  4     2     4  3  3  3  4  3  3  3     3  2  3|     40  3.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |    2     4  2  2        2  3  2  2  3  2  2  2     2  1  2  2            |     36  2.1|
      Hyperplasia, Lymphoid                |       2           2                                                      |      3  2.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia, Lymphoid                |                                                                          |      3  2.0|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                   2                                                      |      2  2.0|
      Metaplasia, Squamous                 |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |    3                                                     4               |      2  3.5|
      Subcutaneous Tissue, Angiectasis     |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |    3                                                                     |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  3.0|
      Fibrous Osteodystrophy               |    1              2                             2     1        1         |     14  1.4|
      Inflammation, Chronic                |                                                 1                        |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Mononuclear Cell                |                                                                         1|      2  2.0|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Squamous Epithelium, Hyperplasia     | 1  1        1                 1                 1        1     1     2   |     17  1.2|

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 5| 6| 7| 6| 6| 5| 5| 6| 6| 6| 6| 5| 5| 6| 7| 7| 7| 5| 7| 5| 6| 6|            |
                             DAY ON TEST   | 1| 3| 8| 3| 5| 3| 8| 4| 8| 3| 1| 8| 8| 4| 3| 3| 7| 3| 3| 0| 1| 3| 4| 4| 3|            |
                                           | 4| 7| 7| 3| 7| 5| 8| 5| 9| 3| 7| 6| 6| 5| 3| 3| 1| 6| 6| 6| 4| 7| 8| 5| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0.03                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Foreign Body                         | X  X  X  X  X  X  X  X  X  X  1  X  X  X  X  X  X  X  X  X  X  X  X  X  X|     49  1.0|
      Hemorrhage                           |                         1                                                |      3  1.0|
      Inflammation, Chronic Active         | 2  2  4  2  3  3  3  4  3  2  3  3     3  4  4  3  3  2  2  4  2  4  2  3|     49  2.9|
      Alveolar Epithelium, Hyperplasia     |                                                             2            |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |    2                             2                                       |      2  2.0|
      Alveolus, Proteinosis                | 1  1        2  1  1           1  1  1  2  1        1  1  1  1  1         |     31  1.1|
      Artery, Inflammation                 |                         4                                                |      1  4.0|
      Interstitium, Fibrosis               |                                                                          |      1  1.0|
      Serosa, Fibrosis                     | 4  3  3  3  4  4  4  4  4  4  4  4  4  4  4  4  4  3  4  4  4  3  4  4  4|     50  3.8|
      Serosa, Metaplasia, Osseous          |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |    1                                            1  1                     |      7  1.1|
      Olfactory Epithelium, Atrophy        |             1                                                            |      1  1.0|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |       1                                         1                        |      3  1.0|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |       1        1              1     1     1     1  1           1         |     17  1.1|

                                            __________________________________________________________________________|____________|
   Pleura                                  | +              +  +                 +     +     +  +     +  +           +|  16        |
      Mesothelium, Hyperplasia             | 4              1  1                 1     1     3  1     2  2           2|     16  1.8|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Metaplasia, Osseous                  |                      1                          1                        |      3  1.3|
      Nephropathy                          | 1  1  1     1  2  1           1  3  1        1  1  1  1  1  1            |     30  1.1|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      1  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 8| 2| 4| 6| 3| 3| 3| 3| 3| 8| 3| 9| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 8| 3| 3|             
                                           | 7| 9| 7| 4| 6| 6| 6| 7| 5| 1| 6| 1| 6| 7| 7| 7| 7| 7| 7| 6| 6| 5| 9| 6| 7|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.1MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     STOP                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                   2                                         1            |             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                            1                                             |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                          |             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Eosinophilic Focus                   |                                     X                       X            |             
      Hematopoietic Cell Proliferation     |                         2  3                       2                     |             
      Inflammation                         |    2                                                                     |             
      Necrosis                             |    3        1     3     1        2                       1               |             
      Tension Lipidosis                    |                      X                                   X               |             
      Vacuolization Cytoplasmic            |                                                                          |             

                                            __________________________________________________________________________|             
   Mesentery                               |                +  +                 +        +           +           +   |             
      Artery, Inflammation                 |                                                          2               |             
      Fat, Necrosis                        |                2  2                 3        4                       3   |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      1                                                   |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Epithelium, Hyperplasia              |                                  2                          3            |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Epithelium, Hyperplasia              |                                                                2         |             

                                            __________________________________________________________________________|             
   Tooth                                   | +                                                                        |             
      Inflammation                         | 2                                                                        |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1     1  1  1  1  1  1  2  3  1  1  1  1  1     1  1  2  2  1     1  2|             
      Mineralization                       |                                  1                                       |             
      Artery, Inflammation                 |                               3              2  2  2  1                 2|             
      Atrium, Thrombosis                   |                                                 2                        |             
      Valve, Inflammation                  |                                        2                                 |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 8| 2| 4| 6| 3| 3| 3| 3| 3| 8| 3| 9| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 8| 3| 3|             
                                           | 7| 9| 7| 4| 6| 6| 6| 7| 5| 1| 6| 1| 6| 7| 7| 7| 7| 7| 7| 6| 6| 5| 9| 6| 7|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.1MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     STOP                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |       3                                                                  |             
      Hematopoietic Cell Proliferation     |                                                 1                        |             
      Hypertrophy                          |                                                                         1|             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                    2              2      |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           1                              |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  M  M  M  +  +  +  +  +  M  M  M  M  +  +  +  +  +  M|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |    2           2     2  2              1  1  2     2     1  2  1     1  1|             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                1        2|             
      Follicular Cell, Hyperplasia         | 2                                                                        |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  M  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  M|             
      Cyst                                 |          2                                2        2        4     1  2   |             
      Thrombosis                           |                                                             4            |             
      Interstitial Cell, Hyperplasia       |                                                                          |             

                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                             2            |             
      Hydrometra                           |       2        2     4                       2                           |             
      Hyperplasia, Cystic                  |    2        2  1  2  2  2     3  1  2  2  3  3     2     1  1  1     1  1|             
      Inflammation, Suppurative            |                         4                                                |             
      Thrombosis                           |    4                                                                     |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hyperplasia                          |                         3  3                             2              2|             

                                            __________________________________________________________________________|             
   Lymph Node                              |       +              +                                   +        +      |             
      Lumbar, Angiectasis                  |                                                                          |             
      Lumbar, Hemorrhage                   |                                                                          |             
      Lumbar, Inflammation, Chronic        |                                                                          |             
      Renal, Angiectasis                   |                                                          3               |             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Foreign Body                         | 1        1  1  1  1     1  1  1     1  1  1  1  1        1  1  1         |             
      Hyperplasia                          | 3        2  2  2  2     2  2  2     2  2  2     2        3  2  3        2|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 8| 2| 4| 6| 3| 3| 3| 3| 3| 8| 3| 9| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 8| 3| 3|             
                                           | 7| 9| 7| 4| 6| 6| 6| 7| 5| 1| 6| 1| 6| 7| 7| 7| 7| 7| 7| 6| 6| 5| 9| 6| 7|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.1MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     STOP                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Artery, Inflammation                 |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3           2                       2                                    |             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |    1                          1              1                           |             
      Hyperplasia                          | 2  1     2     2           2  2              2           2               |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    2           2  1     2  3  2     2     1  3  2        2  1  2     2   |             
      Hyperplasia, Lymphoid                |                                        2                                3|             
      Metaplasia, Osseous                  |                                                                          |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                2     2   |             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  3                                       |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                           2                              |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                   1  1              2  3           2  1              1   |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Mononuclear Cell                |          1                                                               |             

                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |    1                                                                     |             
      Squamous Epithelium, Hyperplasia     | 1                          1                                         1   |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |    X  X  X  X  X     X  X  X        X  X  X     X  X  X  X  X  X  X  X  X|             
      Hemorrhage                           |                                                 1                    1   |             
      Inflammation, Chronic Active         | 2        2  2  2  2  2  2  2  2  2  1  2  2  2  3  1  2  2  3  1     1  2|             
      Thrombosis                           |                            1                                             |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                  3                          2            |             
      Artery, Inflammation                 |                1                                                         |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 8| 2| 4| 6| 3| 3| 3| 3| 3| 8| 3| 9| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 8| 3| 3|             
                                           | 7| 9| 7| 4| 6| 6| 6| 7| 5| 1| 6| 1| 6| 7| 7| 7| 7| 7| 7| 6| 6| 5| 9| 6| 7|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.1MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     STOP                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Artery, Mediastinum, Inflammation    |                               2                                          |             
      Serosa, Fibrosis                     | 2  1     2  2  2  2  2  2  2  2  2  1  2  2  2  2  1  1  2  3  1     2  2|             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |    2                 1  1                                                |             
      Olfactory Epithelium, Atrophy        |                                                                          |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |                                                    1     1     1         |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         | 1     1     2        1  1                 1  1     1  2  2  1  1     1  1|             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             

                                            __________________________________________________________________________|             
   Pleura                                  |                      +     +                             +               |             
      Mesothelium, Hyperplasia             |                      2     1                             2               |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                +                                                         |             
      Degeneration                         |                4                                                         |             

                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                                            +            |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       3                                                                  |             
      Metaplasia, Osseous                  |                   1     1                    1                           |             
      Nephropathy                          | 1  1     1  1  1  1  1  1  1  1  1  1  1  1  2  1  1  1  1  1  1         |             
      Artery, Inflammation                 |                                                 1                        |             
      Renal Tubule, Karyomegaly            |                   2                                                      |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      1                                      1            |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 1| 9| 3| 3| 7| 3| 3| 3| 3| 2| 8| 3| 5| 3| 3| 3| 3| 3| 9| 8| 7| 3| 3|            |
                                           | 5| 5| 7| 9| 6| 5| 2| 6| 5| 6| 7| 8| 7| 5| 8| 7| 6| 7| 6| 5| 9| 5| 2| 6| 6|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    0.1MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Suppurative            |                         1                                                |      3  1.3|

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Hyperplasia              |                                                          2               |      1  2.0|

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                         1                                                |      1  1.0|
      Eosinophilic Focus                   |    X                                         X                           |      4     |
      Hematopoietic Cell Proliferation     |                                                                   2      |      4  2.3|
      Inflammation                         |                                                                          |      1  2.0|
      Necrosis                             |             1                                                  1     1   |      9  1.6|
      Tension Lipidosis                    |                                                                          |      2     |
      Vacuolization Cytoplasmic            |          2                                                               |      1  2.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                                +                                 |   8        |
      Artery, Inflammation                 |                                        1                                 |      2  1.5|
      Fat, Necrosis                        |       3                                                                  |      6  2.8|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                   3                                                      |      1  3.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                     1     1                              |      2  1.0|
      Epithelium, Hyperplasia              |                                     3     1                              |      4  2.3|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                    2                     |      1  2.0|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Tooth                                   |                         +                                                |   2        |
      Inflammation                         |                         3                                                |      2  2.5|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  1     1  1  1  2  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|     46  1.2|
      Mineralization                       |                                           2                              |      2  1.5|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 1| 9| 3| 3| 7| 3| 3| 3| 3| 2| 8| 3| 5| 3| 3| 3| 3| 3| 9| 8| 7| 3| 3|            |
                                           | 5| 5| 7| 9| 6| 5| 2| 6| 5| 6| 7| 8| 7| 5| 8| 7| 6| 7| 6| 5| 9| 5| 2| 6| 6|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    0.1MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Artery, Inflammation                 | 1                    1                          2  3                 1   |     11  1.8|
      Atrium, Thrombosis                   |                                                                          |      1  2.0|
      Valve, Inflammation                  |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hypertrophy                          |                                                                1        2|      3  1.3|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      2  2.0|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    3                                                                     |      2  2.0|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  M  M  +  M  +  M  +  M  M  +  +  +  M  +  I  +  M  M  +  +  M|  29        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Hyperplasia           | 1                    2  3     1           2        1     1     1         |     21  1.5|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                      2                                   2               |      4  1.8|
      Follicular Cell, Hyperplasia         |                                                                      1   |      2  1.5|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  I  +  M|  41        |

                                            __________________________________________________________________________|____________|
   Ovary                                   | M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +|  44        |
      Cyst                                 |                      3              2  2              4           2      |     11  2.4|
      Thrombosis                           |                                                                          |      1  4.0|
      Interstitial Cell, Hyperplasia       |                               1                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Oviduct                                 |                                              +                           |   1        |

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                   4     2                                                |      3  2.7|
      Hydrometra                           |             3                 4              3  3                        |      8  2.9|
      Hyperplasia, Cystic                  |       2  2  3  3  3  1  3  2  1  2  1  2     1        2  3  2  2        3|     36  1.9|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Thrombosis                           |                                                                          |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 1| 9| 3| 3| 7| 3| 3| 3| 3| 2| 8| 3| 5| 3| 3| 3| 3| 3| 9| 8| 7| 3| 3|            |
                                           | 5| 5| 7| 9| 6| 5| 2| 6| 5| 6| 7| 8| 7| 5| 8| 7| 6| 7| 6| 5| 9| 5| 2| 6| 6|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    0.1MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Fibrosis                             |                                                       3                  |      1  3.0|
      Hyperplasia                          |                                                    3                     |      5  2.6|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +  +                                                               |   6        |
      Lumbar, Angiectasis                  |          4                                                               |      1  4.0|
      Lumbar, Hemorrhage                   |          4                                                               |      1  4.0|
      Lumbar, Inflammation, Chronic        |          3                                                               |      1  3.0|
      Renal, Angiectasis                   |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  48        |
      Foreign Body                         | 1        1  1  1  1  1  1        1  1  1  1  1     1     1  1     1  1   |     33  1.0|
      Hyperplasia                          | 2        2  3  2  2  2  2  2        2  2     2     3     2  2     3      |     31  2.2|
      Artery, Inflammation                 |                                     2                                    |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  M|  43        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    2              2              2                       2               |      7  2.1|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  M  +  +  M  +  +  +  +  +|  46        |
      Foreign Body                         |                                           1        1              1     1|      7  1.0|
      Hyperplasia                          |                                                    3              3     3|     11  2.2|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |             1     2  2  2  1        3  2        2  2     2        2  2   |     26  1.9|
      Hyperplasia, Lymphoid                | 2  2        2     2  2        2              2  2        2               |     11  2.1|
      Metaplasia, Osseous                  |       1                                                                  |      1  1.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  M  +  M  M|  42        |
      Hyperplasia, Lymphoid                |                                                          2               |      3  2.0|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                  2                    2              2   |      4  2.3|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               | 1              2  1           1                    2  1  4               |     14  1.6|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Mononuclear Cell                |                                        1                                 |      2  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 1| 9| 3| 3| 7| 3| 3| 3| 3| 2| 8| 3| 5| 3| 3| 3| 3| 3| 9| 8| 7| 3| 3|            |
                                           | 5| 5| 7| 9| 6| 5| 2| 6| 5| 6| 7| 8| 7| 5| 8| 7| 6| 7| 6| 5| 9| 5| 2| 6| 6|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    0.1MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Spinal Cord                             |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Squamous Epithelium, Hyperplasia     | 1     1     1                 2           2        1                 1   |     10  1.2|

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         | X        X  X  X     X           X  X     X  X  X           X  X  X  X  X|     35     |
      Hemorrhage                           |                   1                                                  1   |      4  1.0|
      Inflammation, Chronic Active         | 2  1  1  2  2  2  1  1  1  2  2  2  1  2     1  1  2  1  2  2     2  1  2|     45  1.7|
      Thrombosis                           |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                              3                           |      1  3.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      2  2.5|
      Artery, Inflammation                 |                                                                          |      1  1.0|
      Artery, Mediastinum, Inflammation    |                                                                          |      1  2.0|
      Serosa, Fibrosis                     | 2  1  3  2  2  2     2  2  2  2  1  1  2  2  1  2  2  2  2  2  2  2  1  2|     47  1.8|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            | 1                 1                                         2        1   |      7  1.3|
      Olfactory Epithelium, Atrophy        |    1                             1                 1                     |      3  1.0|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |    1        1        1                       1        2     2        1   |     10  1.2|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |    1        2  1     1  2              1  1  2        2  1  1  1  1      |     27  1.3|
      Respiratory Epithelium, Hyperplasia  |                                                             2            |      1  2.0|

                                            __________________________________________________________________________|____________|
   Pleura                                  |                                                                          |   3        |
      Mesothelium, Hyperplasia             |                                                                          |      3  1.7|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Degeneration                         |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  3.0|
      Metaplasia, Osseous                  |                                                                1         |      4  1.0|
      Nephropathy                          | 1  1     1  1  1  1  1  1  1  1  1     1     1  1  1  1  1  1  1  1  1  1|     43  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 1| 9| 3| 3| 7| 3| 3| 3| 3| 2| 8| 3| 5| 3| 3| 3| 3| 3| 9| 8| 7| 3| 3|            |
                                           | 5| 5| 7| 9| 6| 5| 2| 6| 5| 6| 7| 8| 7| 5| 8| 7| 6| 7| 6| 5| 9| 5| 2| 6| 6|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    0.1MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Artery, Inflammation                 |                                                                          |      1  1.0|
      Renal Tubule, Karyomegaly            |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |             1                                                            |      3  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 6| 7| 4| 7| 6| 7| 5| 6| 7| 7| 5| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 0| 2| 3| 3| 1| 4| 3| 5| 3| 9| 3| 4| 3| 7| 5| 3| 3| 1| 9| 8|             
                                           | 7| 7| 6| 5| 7| 0| 9| 7| 5| 0| 5| 5| 8| 7| 3| 6| 2| 7| 8| 0| 7| 6| 2| 5| 7|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.3MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     STOP                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  A  +  +  +  +  +  +  M  +  A  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |                                                                          |             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                    1                     |             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |    X  X              X           X     X     X  X                        |             
      Eosinophilic Focus, Multiple         |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                       3                  |             
      Necrosis                             |                                     2                                1   |             
      Tension Lipidosis                    |                                                    X                     |             
      Bile Duct, Degeneration, Hyaline     |                                                                          |             

                                            __________________________________________________________________________|             
   Mesentery                               | +                             +        +                                 |             
      Artery, Inflammation                 |                                        1                                 |             
      Fat, Necrosis                        | 1                             2                                          |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                          1  1            |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                              X                           |             
      Inflammation, Chronic                |                                              2                           |             
      Epithelium, Hyperplasia              |                                                       1                  |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                       2                  |             
      Necrosis, Focal                      |                                     2                                    |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  1  1  1     1  1  1     1  1     1  1  1  1  1  2  1  1  1     1  1|             
      Necrosis                             |                                                                          |             
      Artery, Inflammation                 |       1  2     1                 2           1                 3         |             
      Atrium, Thrombosis                   |                                                                          |             
      Epicardium, Inflammation             |                   2     1                                      1         |             
      Pericardium, Inflammation            |       3                                                     2  2     3   |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 6| 7| 4| 7| 6| 7| 5| 6| 7| 7| 5| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 0| 2| 3| 3| 1| 4| 3| 5| 3| 9| 3| 4| 3| 7| 5| 3| 3| 1| 9| 8|             
                                           | 7| 7| 6| 5| 7| 0| 9| 7| 5| 0| 5| 5| 8| 7| 3| 6| 2| 7| 8| 0| 7| 6| 2| 5| 7|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.3MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     STOP                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Amyloid Deposition                   |                                                                          |             
      Degeneration, Focal                  |                               2                                          |             
      Hyperplasia                          |                                     2                                    |             
      Hypertrophy                          |       1           1  1           1                          1  2         |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia                          | 1                                                                        |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  M  +  M  +  +  +  +  +  +  M  M  M  +  M  M  +  +  M  +  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |    2  1  4           1                 2           4                 1  1|             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                         2                                                |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  M  +  +  +  +  +  M  +  I  +  +  +  +  M  +  +  M  M  +|             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      2                                                   |             
      Cyst                                 |    2        1     2                    1                                 |             
      Thrombosis                           |                                                                          |             
      Interstitial Cell, Hyperplasia       |                      2                                                   |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      2     2                    3     2                  |             
      Hydrometra                           |    4                                            2                 2     2|             
      Hyperplasia, Cystic                  | 1  2  2  2     1  2  2  2        3  2  2           2        3  1  2  2   |             
      Inflammation, Suppurative            |                                              1                           |             
      Thrombosis                           |                            3                          3                  |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2           2  2  2              2                              |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                      +     +  +                 +                        |             
      Iliac, Hematopoietic Cell            |                                                                          |             
          Proliferation                    |                                                                          |             
      Iliac, Hyperplasia                   |                                                 3                        |             
      Lumbar, Hyperplasia                  |                               2                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         | 1  1  1  1  1  1           1  1     1  1  1  1  1  1  1  1  1  1     1  1|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          | 2  2  2  2  3           2  2           2  3     2  2     2     2     4  2|             
      Artery, Inflammation                 |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 6| 7| 4| 7| 6| 7| 5| 6| 7| 7| 5| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 0| 2| 3| 3| 1| 4| 3| 5| 3| 9| 3| 4| 3| 7| 5| 3| 3| 1| 9| 8|             
                                           | 7| 7| 6| 5| 7| 0| 9| 7| 5| 0| 5| 5| 8| 7| 3| 6| 2| 7| 8| 0| 7| 6| 2| 5| 7|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.3MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     STOP                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  M  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  M  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |    2  2  4  2                                                            |             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                         1  1           1  1  1     1  1     1           1|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          | 2     3     2           4  2        2  4  3  2  4  2  2        3     2  2|             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |       1  1  3     2  2     1  2                 2     4  2  2        1   |             
      Hyperplasia, Lymphoid                | 2     2  2              2        2  2  2           2        3  2         |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  M  +  M  +  M  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                    2                     |             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                             2            |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                          4               |             
      Inflammation, Suppurative            |                                                          3               |             
      Hair Follicle, Atrophy               |                                                                   3      |             
      Subcutaneous Tissue, Hemorrhage      |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                          4               |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               | 1  2                 1  1  2        2                             2      |             
      Maxilla, Fracture                    |                                                                          |             

                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Mononuclear Cell                |                               2                                          |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Squamous Epithelium, Hyperplasia     |             2  1  1                 2                 1     2           1|             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         | X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 6| 7| 4| 7| 6| 7| 5| 6| 7| 7| 5| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 0| 2| 3| 3| 1| 4| 3| 5| 3| 9| 3| 4| 3| 7| 5| 3| 3| 1| 9| 8|             
                                           | 7| 7| 6| 5| 7| 0| 9| 7| 5| 0| 5| 5| 8| 7| 3| 6| 2| 7| 8| 0| 7| 6| 2| 5| 7|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.3MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     STOP                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                            1                          4                  |             
      Inflammation, Chronic Active         | 3  2  2  2  2  2  2  2  2  3  1  2  2  2  3  2  2  2  2  2  3  2  2  2  3|             
      Thrombosis                           |             2                                                            |             
      Alveolar Epithelium, Hyperplasia     |                         2                                                |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                              2                           |             
      Alveolus, Proteinosis                |    1  1                                   2                          1   |             
      Bronchiole, Bronchus, Degeneration,  |                                                                          |             
           Hyaline                         |                                                                          |             
      Interstitium, Fibrosis               |                                                       2                  |             
      Serosa, Fibrosis                     | 2  2  4  1  3  3  2  3  4  1  4  2  2  3  4  3  2  2  3  2  4  3  3  4  3|             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |       1                                1                                 |             
      Olfactory Epithelium, Atrophy        |                                                                          |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |                                                    1                     |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |                      1        1     1              1                 1   |             

                                            __________________________________________________________________________|             
   Pleura                                  |       +     +     +                    +  +  +              +  +     +   |             
      Mesothelium, Hyperplasia             |       2     2     4                    1  1  1              2  1     4   |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Hyaline                |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                                                           +      |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Osseous                  |                                        1                                 |             
      Nephropathy                          | 1  1  1     1     1  2        1  1  1  1     1     1  1  1  1  1     1   |             
      Artery, Inflammation                 |                                                 2                        |             
      Glomerulus, Inflammation, Chronic    |                                                                          |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  M  +  +|             
      Angiectasis                          |                                              1                           |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 6| 7| 7| 7| 4| 7| 1| 7| 7| 6| 7| 5| 6| 6| 5| 6| 6| 7| 7| 4| 7|            |
                             DAY ON TEST   | 2| 3| 2| 3| 0| 3| 3| 0| 9| 3| 9| 3| 3| 1| 3| 3| 9| 3| 9| 6| 1| 2| 3| 2| 0|            |
                                           | 1| 6| 7| 5| 8| 6| 5| 5| 6| 6| 7| 6| 6| 5| 5| 3| 5| 3| 4| 9| 9| 6| 7| 1| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    0.3MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Gallbladder                             | M  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  A|  43        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  44        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  44        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Peyer's Patch, Hyperplasia           |                   2                                                      |      1  2.0|

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                            4                                             |      2  2.5|
      Basophilic Focus                     |                         X                             X                  |      2     |
      Clear Cell Focus                     |                                                 X              X         |      2     |
      Eosinophilic Focus                   |    X                                      X        X                     |     10     |
      Eosinophilic Focus, Multiple         |          X                                   X                           |      2     |
      Hematopoietic Cell Proliferation     |             2                             3                              |      3  2.7|
      Necrosis                             |                                                          3               |      3  2.0|
      Tension Lipidosis                    |                                                                          |      1     |
      Bile Duct, Degeneration, Hyaline     |                                           2                              |      1  2.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                                                   |   4        |
      Artery, Inflammation                 |                                                                          |      1  1.0|
      Fat, Necrosis                        |                      2                                                   |      3  1.7|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      2  1.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      1     |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              | 2                                                              2         |      3  1.7|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Necrosis, Focal                      |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |    1  1  1  1  1  1  1     1     1  2     1  2  1        1        1  2  1|     38  1.1|
      Necrosis                             |       1                                                                  |      1  1.0|
      Artery, Inflammation                 |    1                    2                    2  2     2     2        2   |     13  1.8|
      Atrium, Thrombosis                   |                                                       2                  |      1  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 6| 7| 7| 7| 4| 7| 1| 7| 7| 6| 7| 5| 6| 6| 5| 6| 6| 7| 7| 4| 7|            |
                             DAY ON TEST   | 2| 3| 2| 3| 0| 3| 3| 0| 9| 3| 9| 3| 3| 1| 3| 3| 9| 3| 9| 6| 1| 2| 3| 2| 0|            |
                                           | 1| 6| 7| 5| 8| 6| 5| 5| 6| 6| 7| 6| 6| 5| 5| 3| 5| 3| 4| 9| 9| 6| 7| 1| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    0.3MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Epicardium, Inflammation             | 2                       2                          2           1         |      7  1.6|
      Pericardium, Inflammation            |                                                                          |      4  2.5|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   |             2                                         1                  |      2  1.5|
      Degeneration, Focal                  |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Hypertrophy                          | 1  1     1           1                                                   |     10  1.1|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                      1           2                                       |      3  1.3|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                   1                                                      |      1  1.0|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  +  M  +  M  +  M  M  M  +  +  +  +  +  +  +  +  M  +  M  M  M  +|  30        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Hyperplasia           |       2  1           1                 2  1              1        2      |     15  1.7|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +|  40        |

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  M  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Angiectasis                          |                                                                          |      1  2.0|
      Cyst                                 | 2     4     3                                   3  4                     |      9  2.4|
      Thrombosis                           |             3                                      4                     |      2  3.5|
      Interstitial Cell, Hyperplasia       |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                             2            |      5  2.2|
      Hydrometra                           |                                                                   2      |      5  2.4|
      Hyperplasia, Cystic                  | 2  2     3  2  2     3  1  3     2  1        2  2  2        2  3  2      |     32  2.0|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Thrombosis                           |                                                                          |      2  3.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                           3              2               |      7  2.1|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 6| 7| 7| 7| 4| 7| 1| 7| 7| 6| 7| 5| 6| 6| 5| 6| 6| 7| 7| 4| 7|            |
                             DAY ON TEST   | 2| 3| 2| 3| 0| 3| 3| 0| 9| 3| 9| 3| 3| 1| 3| 3| 9| 3| 9| 6| 1| 2| 3| 2| 0|            |
                                           | 1| 6| 7| 5| 8| 6| 5| 5| 6| 6| 7| 6| 6| 5| 5| 3| 5| 3| 4| 9| 9| 6| 7| 1| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    0.3MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                      +                    +     +              +         |   8        |
      Iliac, Hematopoietic Cell            |                                                                          |            |
          Proliferation                    |                                           2                              |      1  2.0|
      Iliac, Hyperplasia                   |                                                                          |      1  3.0|
      Lumbar, Hyperplasia                  |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         | 1  1        1  1  1  1  1  1  1  1  1  1     1     1  1  1  1     1  1  1|     40  1.0|
      Hematopoietic Cell Proliferation     |                                           2                              |      1  2.0|
      Hyperplasia                          | 2  4        2     2     2     2  2     2              1  2  2     2  2   |     28  2.2|
      Artery, Inflammation                 |                      1                                                   |      1  1.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  M  +  +  +  +  M  +  +|  42        |
      Hematopoietic Cell Proliferation     |                                           2                              |      1  2.0|
      Hyperplasia                          |                   2                                                      |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hematopoietic Cell Proliferation     |                                           4                              |      1  4.0|
      Hyperplasia                          |                   2                          2              2            |      7  2.3|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Foreign Body                         | 1                 1     1     1              1     1              1      |     16  1.0|
      Hematopoietic Cell Proliferation     |                                           2                              |      1  2.0|
      Hyperplasia                          | 3  2              3     2     3  2  4        2     2  2     2     2  3  3|     29  2.6|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     | 2     3     2                          2  3  2     2     3           2   |     21  2.1|
      Hyperplasia, Lymphoid                |                   2              2  4                             4      |     14  2.4|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  42        |
      Hyperplasia, Lymphoid                |    2                                                                     |      2  2.0|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                   2                                                     1|      3  1.7|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Hair Follicle, Atrophy               |                                                                          |      1  3.0|
      Subcutaneous Tissue, Hemorrhage      |                               4                                          |      1  4.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                          |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 6| 7| 7| 7| 4| 7| 1| 7| 7| 6| 7| 5| 6| 6| 5| 6| 6| 7| 7| 4| 7|            |
                             DAY ON TEST   | 2| 3| 2| 3| 0| 3| 3| 0| 9| 3| 9| 3| 3| 1| 3| 3| 9| 3| 9| 6| 1| 2| 3| 2| 0|            |
                                           | 1| 6| 7| 5| 8| 6| 5| 5| 6| 6| 7| 6| 6| 5| 5| 3| 5| 3| 4| 9| 9| 6| 7| 1| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    0.3MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Fibrous Osteodystrophy               |    1  1  2                 1     1              1              1  1     1|     16  1.3|
      Maxilla, Fracture                    |                               X                                          |      1     |

                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |       +                                                                  |   1        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Mononuclear Cell                | 2                                                                        |      2  2.0|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                 1                       1|      2  1.0|
      Squamous Epithelium, Hyperplasia     |       2                 1           2  1        2  1     1  1            |     15  1.4|

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         | X  X  X     X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X|     49     |
      Hematopoietic Cell Proliferation     |                                           3                              |      1  3.0|
      Hemorrhage                           |                               2                       1                  |      4  2.0|
      Inflammation, Chronic Active         | 2  2  2  2  2  2  1  2  3  1  3  1  3  2  2  2  2  2  2  2  2  2  2  3  2|     50  2.1|
      Thrombosis                           |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |          2                                                               |      2  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                           3                       2      |      3  2.3|
      Alveolus, Proteinosis                |                         1     2  1                                   2   |      8  1.4|
      Bronchiole, Bronchus, Degeneration,  |                                                                          |            |
           Hyaline                         |       3                                   2                              |      2  2.5|
      Interstitium, Fibrosis               |                                                                      1   |      2  1.5|
      Serosa, Fibrosis                     | 2  3  2  2  3  1  1  4  4  1  2  1  4  2  1  2  3  2  2  2  3  3     2  3|     49  2.5|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                          |      2  1.0|
      Olfactory Epithelium, Atrophy        |                      1                                   1               |      2  1.0|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |                   1                                                      |      2  1.0|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |       1        1  2     1        1        3     1           1  1         |     14  1.2|

                                            __________________________________________________________________________|____________|
   Pleura                                  |                                              +  +        +              +|  13        |
      Mesothelium, Hyperplasia             |                                              1  3        1              2|     13  1.9|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Hyaline                |                                           2                              |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 6| 7| 7| 7| 4| 7| 1| 7| 7| 6| 7| 5| 6| 6| 5| 6| 6| 7| 7| 4| 7|            |
                             DAY ON TEST   | 2| 3| 2| 3| 0| 3| 3| 0| 9| 3| 9| 3| 3| 1| 3| 3| 9| 3| 9| 6| 1| 2| 3| 2| 0|            |
                                           | 1| 6| 7| 5| 8| 6| 5| 5| 6| 6| 7| 6| 6| 5| 5| 3| 5| 3| 4| 9| 9| 6| 7| 1| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    0.3MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Metaplasia, Osseous                  |                                                    1                     |      2  1.0|
      Nephropathy                          |    1  1  1  1  1  1  1  1  1        1     1  1  1     1  3     1  1  1  1|     36  1.1|
      Artery, Inflammation                 |                                                          2           2   |      3  2.0|
      Glomerulus, Inflammation, Chronic    |                                                    2                     |      1  2.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |          2                                                               |      2  1.5|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 2| 3| 3| 1| 3| 3| 3| 5| 3| 3| 6| 3| 3| 3|             
                                           | 6| 3| 3| 5| 3| 3| 4| 3| 1| 4| 4| 6| 4| 4| 6| 5| 4| 4| 9| 4| 4| 4| 4| 4| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Gallbladder                             | A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Peyer's Patch, Hyperplasia           |                2              4                          2               |             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                            1                                             |             
      Basophilic Focus                     |                                  X                    X                  |             
      Clear Cell Focus                     |                                                                          |             
      Clear Cell Focus, Multiple           |                                                    X                     |             
      Eosinophilic Focus                   |                                     X  X                    X           X|             
      Eosinophilic Focus, Multiple         |                                                    X                     |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Necrosis                             |                                                                          |             
      Tension Lipidosis                    |                      X                                      X            |             
      Vacuolization Cytoplasmic            |                                                                          |             

                                            __________________________________________________________________________|             
   Mesentery                               |                                     +  +           +                     |             
      Fat, Necrosis                        |                                     3  2           3                     |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                            1     1                                       |             
      Duct, Cyst                           |    2                                                                     |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                     1                                    |             
      Ulcer                                |                                                                1         |             
      Epithelium, Hyperplasia              |                                  3                             1         |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Mineralization                       |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1  1     1  1  1     1  1     1  1  1  1  1  1  1  2  1  1  1  1     1|             
      Artery, Inflammation                 |                      1                 1              1                  |             
      Artery, Mineralization               |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 2| 3| 3| 1| 3| 3| 3| 5| 3| 3| 6| 3| 3| 3|             
                                           | 6| 3| 3| 5| 3| 3| 4| 3| 1| 4| 4| 6| 4| 4| 6| 5| 4| 4| 9| 4| 4| 4| 4| 4| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                      2                                                   |             
      Hypertrophy                          | 1  2  1     1     2        1  2     2     1  1     1  1  1     1  1     1|             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                       1  1               |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               1  3           1           1              1|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  M  +  M  +  +  +  +  +  M  M  +  M  +  M  +  M  +  +  M  +  +  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  M  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Degeneration, Cystic       |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                  2                                       |             
      Inflammation                         |                                                                          |             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |    2  2        2  2           3     2  2           3     3  1     3      |             
      Hyperplasia, Squamous                |                                                                2         |             
      Inflammation                         |                2     4                                                   |             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                         2|             
      Atrophy                              |          1     2           1                             2               |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      2           2                                   2   |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  M  +  M  +  +  M  +  +  M  +  M  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                2         |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  M  +  +  +  +  +  M  +  +  +  M  +  +  +  M  +  M  M  +  M  +  M  +|             
      Hyperplasia                          |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                            2                                             |             
      Hyperplasia                          |                2              2           2              3              2|             
      Inflammation, Granulomatous          |                                                                          |             
      Artery, Inflammation                 |                2                                                         |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 2| 3| 3| 1| 3| 3| 3| 5| 3| 3| 6| 3| 3| 3|             
                                           | 6| 3| 3| 5| 3| 3| 4| 3| 1| 4| 4| 6| 4| 4| 6| 5| 4| 4| 9| 4| 4| 4| 4| 4| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  +  +  +  +  +  M  M  +  +  M  +  M  +  +  M  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                   3      |             
      Hematopoietic Cell Proliferation     | 2                    1  2  1              2                          2   |             

                                            __________________________________________________________________________|             
   Thymus                                  | M  M  +  M  +  +  +  M  I  +  +  M  +  M  M  +  +  +  +  M  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      2                                                   |             
      Prepuce, Inflammation, Chronic Active|                                                                          |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                            1                                             |             
      Hyperplasia                          |                                                                2         |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Spinal Cord                             |          +                                                               |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                  1                    1                  |             
      Epiglottis, Metaplasia, Squamous     |                                                                          |             
      Squamous Epithelium, Hyperplasia     |                         1                                            2   |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                      1  1                                      3         |             
      Inflammation, Chronic Active         |             1                                                           1|             
      Inflammation, Suppurative            |                                  1                                       |             
      Thrombosis                           |                                  1                                       |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Bronchiole, Hyperplasia              |                                  1                                       |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |             1     1                                                      |             
      Olfactory Epithelium, Atrophy        |                   1                                                      |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |                                                                          |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |       1                                      1                           |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 2| 3| 3| 1| 3| 3| 3| 5| 3| 3| 6| 3| 3| 3|             
                                           | 6| 3| 3| 5| 3| 3| 4| 3| 1| 4| 4| 6| 4| 4| 6| 5| 4| 4| 9| 4| 4| 4| 4| 4| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                            2                                             |             
      Metaplasia, Osseous                  |             1                    1                                1      |             
      Nephropathy                          | 1  1  1        1  1  1  1  1  1  1  1  1  3  4  1  1     1  1  1  1  2  1|             
      Glomerulus, Inflammation, Chronic    |                                                                          |             
      Renal Tubule, Hyperplasia            | 2                                                                       1|             

                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 3| 9| 6| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 6| 3| 3| 3| 0| 3| 3| 6|            |
                                           | 5| 3| 5| 0| 2| 4| 3| 3| 5| 3| 3| 6| 3| 4| 3| 3| 4| 9| 3| 5| 5| 7| 3| 4| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  M  +  +  +  +  +  +  A  +  +  +  +  +  M  +  +  +  +  +  +  A|  43        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A|  47        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  M  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +|  43        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  47        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A|  45        |
      Peyer's Patch, Hyperplasia           |          1                    2                                          |      5  2.2|

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  1.0|
      Basophilic Focus                     |                                                                          |      2     |
      Clear Cell Focus                     |                            X                                             |      1     |
      Clear Cell Focus, Multiple           |                                                                          |      1     |
      Eosinophilic Focus                   |       X  X        X                             X              X         |      9     |
      Eosinophilic Focus, Multiple         |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                                                    3                     |      1  3.0|
      Inflammation, Focal, Granulomatous   |                                                                   1      |      1  1.0|
      Necrosis                             |             4           2                          2           2         |      4  2.5|
      Tension Lipidosis                    |                                                                          |      2     |
      Vacuolization Cytoplasmic            |                            2                    2                        |      2  2.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                             +            |   4        |
      Fat, Necrosis                        |                                                             2            |      4  2.5|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                1                                                         |      3  1.0|
      Duct, Cyst                           |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Ulcer                                |                                                                          |      1  1.0|
      Epithelium, Hyperplasia              |                                                                          |      2  2.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                   2                                                      |      1  2.0|
      Necrosis, Focal                      |          1                                                               |      1  1.0|
      Epithelium, Hyperplasia              |                                                                      2   |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            |             +                                                            |   1        |
      Mineralization                       |             3                                                            |      1  3.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 3| 9| 6| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 6| 3| 3| 3| 0| 3| 3| 6|            |
                                           | 5| 3| 5| 0| 2| 4| 3| 3| 5| 3| 3| 6| 3| 4| 3| 3| 4| 9| 3| 5| 5| 7| 3| 4| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |    1        1     4  1  1  1  1     1  1  1  1  1  1  1  1  1     1  1  1|     39  1.1|
      Artery, Inflammation                 |                                                                          |      3  1.0|
      Artery, Mineralization               |             2                                                            |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                                                    1                     |      1  1.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Hypertrophy                          |                2  2  2     1  1  1  1  1  2  2  2        1        1  1   |     30  1.3|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                2                                                         |      3  1.3|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          4                 1  1                                          |      8  1.6|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  M  +  +  +  M  +  +  M  M  +  +  +  M  +  +  +  +  M  M  +  +  +|  33        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Follicle, Degeneration, Cystic       |                            2                                             |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |             4                                                            |      2  3.0|
      Inflammation                         |                                                             2            |      1  2.0|

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              | 2  2  2     2     2  2     2        2  3     3  2  3        3  2         |     25  2.3|
      Hyperplasia, Squamous                |                                                                          |      1  2.0|
      Inflammation                         |                         3                             3           2      |      5  2.8|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Atrophy                              |                                  2                          2            |      6  1.7|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                       2     2            |      5  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 3| 9| 6| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 6| 3| 3| 3| 0| 3| 3| 6|            |
                                           | 5| 3| 5| 0| 2| 4| 3| 3| 5| 3| 3| 6| 3| 4| 3| 3| 4| 9| 3| 5| 5| 7| 3| 4| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                  +                                       |   1        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  M  +  +  M  +  +  +  +  +  M  +  M  +  M  +  +  +  M  +  M  +|  35        |
      Hyperplasia                          |    3                                                                     |      2  2.5|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  M  M  M  M  +  M  M  +  M  +  +  +  M  M  M  +  M  +  +  M  M|  28        |
      Hyperplasia                          |                                                          2               |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hyperplasia                          |       2        2              2     3              2              3      |     11  2.3|
      Inflammation, Granulomatous          |                      3                                               2   |      2  2.5|
      Artery, Inflammation                 |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  40        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |             2                                                            |      2  2.5|
      Hematopoietic Cell Proliferation     |             1     1  1  2                          4  1     1  2         |     14  1.6|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  M  +  M  M  +  +  +  M  +|  35        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                       2                  |      2  2.0|
      Prepuce, Inflammation, Chronic Active|                                                             4            |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrous Osteodystrophy               |                                     1                                    |      2  1.0|
      Hyperplasia                          |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |          1  1                             1                              |      5  1.0|
      Epiglottis, Metaplasia, Squamous     |    1                                                                     |      1  1.0|
      Squamous Epithelium, Hyperplasia     |          1                             1  1  2                           |      6  1.3|

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                        1                             1   |      5  1.4|
      Inflammation, Chronic Active         |                                                                          |      2  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 3| 9| 6| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 6| 3| 3| 3| 0| 3| 3| 6|            |
                                           | 5| 3| 5| 0| 2| 4| 3| 3| 5| 3| 3| 6| 3| 4| 3| 3| 4| 9| 3| 5| 5| 7| 3| 4| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Thrombosis                           |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                       2              1   |      2  1.5|
      Bronchiole, Hyperplasia              |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |          1                                                               |      3  1.0|
      Olfactory Epithelium, Atrophy        |                                                             1            |      2  1.0|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |                                                                         1|      1  1.0|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |    1  1                                                                 1|      5  1.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|  48        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                      +                                                   |   1        |

                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                   +                                                      |   1        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                            2                                             |      2  2.0|
      Metaplasia, Osseous                  |                            1           1                                 |      5  1.0|
      Nephropathy                          | 1  1  1  1  4  2  1  2  2  1  1  1  1  1  1  1  1  1  1  2  2  1  1  1  1|     47  1.3|
      Glomerulus, Inflammation, Chronic    |                                                    2                     |      1  2.0|
      Renal Tubule, Hyperplasia            |          1                    1           1                              |      5  1.2|

                                            __________________________________________________________________________|____________|
   Ureter                                  |                               +                                          |   1        |

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 5| 7| 7| 7| 7| 6| 7| 5| 4| 5| 6| 7| 7| 7| 7| 3| 5| 7| 4| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 8| 3| 2| 0| 3| 3| 3| 3| 7| 2| 7| 8| 3| 3| 3| 3| 3| 5| 3| 5| 3| 6| 3|             
                                           | 5| 5| 9| 0| 9| 0| 3| 3| 8| 4| 4| 1| 1| 2| 5| 3| 0| 5| 1| 7| 4| 7| 3| 2| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.03                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Hyaline                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +|             
      Inflammation, Chronic                |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Amyloid Deposition                   |                                                                          |             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                      2   |             
      Basophilic Focus                     |                                              X                           |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   | X                 X  X     X  X                             X            |             
      Eosinophilic Focus, Multiple         |                                                                          |             
      Necrosis                             |          4                    2     3                                    |             
      Tension Lipidosis                    |                                                                          |             

                                            __________________________________________________________________________|             
   Mesentery                               |                                           +              +               |             
      Artery, Inflammation                 |                                           4              4               |             
      Fat, Necrosis                        |                                                                          |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mast Cell     |                                           2                              |             
      Ulcer                                |                                                                          |             
      Artery, Inflammation                 |                                                                          |             
      Epithelium, Hyperplasia              |                               1        1                                 |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Inflammation                         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            |                               +                                          |             
      Aorta, Aneurysm                      |                                                                          |             
      Aorta, Hemorrhage                    |                                                                          |             
      Aorta, Inflammation                  |                                                                          |             
      Aorta, Mineralization                |                               2                                          |             
      Aorta, Necrosis                      |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1     1  1  1  1  1  1  1     1     1  1  1  2  1        1  1  1     2|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 5| 7| 7| 7| 7| 6| 7| 5| 4| 5| 6| 7| 7| 7| 7| 3| 5| 7| 4| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 8| 3| 2| 0| 3| 3| 3| 3| 7| 2| 7| 8| 3| 3| 3| 3| 3| 5| 3| 5| 3| 6| 3|             
                                           | 5| 5| 9| 0| 9| 0| 3| 3| 8| 4| 4| 1| 1| 2| 5| 3| 0| 5| 1| 7| 4| 7| 3| 2| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.03                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |          2                                                               |             
      Artery, Inflammation                 |                2                 1     1        2              1        1|             
      Atrium, Inflammation, Chronic        |                            1                                             |             
      Atrium, Thrombosis                   |                                  2                                       |             
      Epicardium, Inflammation             |                2                                                         |             
      Pericardium, Inflammation            |    2                                            3                        |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                      2   |             
      Angiectasis                          |                                                                          |             
      Degeneration, Focal                  |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |    1     1  1              1              1  1                          1|             
      Necrosis                             |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                             2            |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  M  M  +  +  M  I  +  M  +  +  +  M  +  +  +  +  +  +  M  M  M|             
      Amyloid Deposition                   |                                                                          |             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Pars Distalis, Hyperplasia           |                                                                          |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Amyloid Deposition                   |                                                                      2   |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |       2                    2  2              3  2  3        2           3|             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                   2      |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2                    1                             1         |             

                                            __________________________________________________________________________|             
   Lymph Node                              |             +                                                            |             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         | 1  1  1  1     1  1  1  1  1  1  1     1  1  1  1  1  1  1     1     1  1|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 5| 7| 7| 7| 7| 6| 7| 5| 4| 5| 6| 7| 7| 7| 7| 3| 5| 7| 4| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 8| 3| 2| 0| 3| 3| 3| 3| 7| 2| 7| 8| 3| 3| 3| 3| 3| 5| 3| 5| 3| 6| 3|             
                                           | 5| 5| 9| 0| 9| 0| 3| 3| 8| 4| 4| 1| 1| 2| 5| 3| 0| 5| 1| 7| 4| 7| 3| 2| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.03                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          | 2  3  2  2     2  4  4  2  3  2  1  2     2  2  2     2        2     2   |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  +  +  +  +  +  M  +  +  M  +  M  +  +  M  +  +  M  +  +  +  M  M|             
      Hyperplasia                          |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia                          |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |       1  1              1     1              1  1  1     1               |             
      Hematopoietic Cell Proliferation     |          2                                                               |             
      Hyperplasia                          | 3  2  2  2        4  4  2  3  2     2  2     2  2  4  2  1  2            |             
      Artery, Inflammation                 |                                                             1            |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                      3   |             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |    2  3  3  4  2  3  2     1  2  2  2     2     2  1        2  2  3      |             
      Hyperplasia, Lymphoid                |                            2                                             |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  M  M  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M|             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Prepuce, Inflammation, Chronic Active|                                        4                                 |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Maxilla, Fracture                    |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                               1                                          |             
      Squamous Epithelium, Hyperplasia     |                               1                          2               |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         | X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  1  X|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         | 2  3  3  2  2  3  3  3  3  2  2  3  3  2  3  2  4  3  4  3  3  2  3  4  2|             
      Alveolar Epithelium, Hyperplasia     |                      2                                                  2|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Alveolus, Proteinosis                | 1           1                             1  1     1                    1|             
      Artery, Mediastinum, Inflammation    |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 5| 7| 7| 7| 7| 6| 7| 5| 4| 5| 6| 7| 7| 7| 7| 3| 5| 7| 4| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 8| 3| 2| 0| 3| 3| 3| 3| 7| 2| 7| 8| 3| 3| 3| 3| 3| 5| 3| 5| 3| 6| 3|             
                                           | 5| 5| 9| 0| 9| 0| 3| 3| 8| 4| 4| 1| 1| 2| 5| 3| 0| 5| 1| 7| 4| 7| 3| 2| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.03                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Interstitium, Fibrosis               |                                                                          |             
      Serosa, Fibrosis                     | 3  3  4  4  3  4  4  4  4  4  3  2  4  4  4  3  4  4  3  2  3  4  4  2  4|             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                           1        1              1      |             
      Olfactory Epithelium, Atrophy        |                      2                       1                           |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |                      1                                                   |             

                                            __________________________________________________________________________|             
   Pleura                                  |    +     +           +                          +  +        +     +      |             
      Mesothelium, Hyperplasia             |    4     4           1                          2  1        1     1      |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +|             
      Inflammation, Suppurative            |                               2                                          |             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                      +                                                   |             
      Degeneration                         |                      4                                                   |             

                                            __________________________________________________________________________|             
   Harderian Gland                         |                      +                                                   |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                      3   |             
      Cyst                                 |                                                                          |             
      Infiltration Cellular, Focal, Mixed  |                                                                          |             
          Cell                             |                                                                          |             
      Nephropathy                          | 1  1  1  1     2  1     1  1  1  3        1  1  3  1     4  2     2      |             
      Artery, Inflammation                 |                                                 3           1            |             
      Glomerulus, Inflammation, Chronic    |                                                                3         |             
      Renal Tubule, Hyperplasia            |                                           1                              |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                    2                     |             
      Necrosis                             |                               1                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 5| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 4|            |
                             DAY ON TEST   | 3| 6| 1| 0| 3| 3| 3| 3| 0| 0| 3| 8| 0| 0| 3| 3| 3| 3| 8| 8| 3| 6| 3| 3| 0|            |
                                           | 5| 2| 5| 0| 3| 4| 3| 4| 4| 5| 4| 7| 6| 0| 3| 4| 4| 5| 7| 7| 5| 2| 4| 3| 5|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.03                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Gallbladder                             | M  +  A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  A|  43        |
      Degeneration, Hyaline                |                                                          1               |      1  1.0|
      Inflammation, Suppurative            |                                                          1               |      1  1.0|
      Epithelium, Hyperplasia              |                                                          1               |      1  1.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  47        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  I  +  +  +  +  A  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +  A|  43        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  44        |
      Inflammation, Chronic                |                                              2                           |      1  2.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  47        |
      Amyloid Deposition                   |                                                             2            |      1  2.0|

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   |                                                             4            |      2  3.0|
      Basophilic Focus                     |                                                                          |      1     |
      Clear Cell Focus                     |                               X                                          |      1     |
      Eosinophilic Focus                   | X     X              X        X                    X     X  X     X  X   |     15     |
      Eosinophilic Focus, Multiple         |                                                 X                        |      1     |
      Necrosis                             |                         2                                                |      4  2.8|
      Tension Lipidosis                    |                      X                                                   |      1     |

                                            __________________________________________________________________________|____________|
   Mesentery                               |    +  +                                                           +      |   5        |
      Artery, Inflammation                 |    4  2                                                                  |      4  3.5|
      Fat, Necrosis                        |                                                                   2      |      1  2.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mast Cell     |                                                                          |      1  2.0|
      Ulcer                                |                         2                       1                        |      2  1.5|
      Artery, Inflammation                 |                               2                                          |      1  2.0|
      Epithelium, Hyperplasia              |       1                 2     3                 2                        |      6  1.7|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Tooth                                   |                +  +                                                      |   2        |
      Inflammation                         |                2  3                                                      |      2  2.5|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                     +                                    |   2        |
      Aorta, Aneurysm                      |                                     4                                    |      1  4.0|
      Aorta, Hemorrhage                    |                                     4                                    |      1  4.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 5| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 4|            |
                             DAY ON TEST   | 3| 6| 1| 0| 3| 3| 3| 3| 0| 0| 3| 8| 0| 0| 3| 3| 3| 3| 8| 8| 3| 6| 3| 3| 0|            |
                                           | 5| 2| 5| 0| 3| 4| 3| 4| 4| 5| 4| 7| 6| 0| 3| 4| 4| 5| 7| 7| 5| 2| 4| 3| 5|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.03                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Aorta, Inflammation                  |                                     4                                    |      1  4.0|
      Aorta, Mineralization                |                                                                          |      1  2.0|
      Aorta, Necrosis                      |                                     3                                    |      1  3.0|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1     1  1  1  1  1  1  1     2  1  1  1  1  1  1  1  1  1  1     1  1  1|     41  1.1|
      Hemorrhage                           |                                                                          |      1  2.0|
      Artery, Inflammation                 |    3  1        2        1  3  2  2  4        2  2                 1     2|     18  1.8|
      Atrium, Inflammation, Chronic        |                                                                          |      1  1.0|
      Atrium, Thrombosis                   |                                                                          |      1  2.0|
      Epicardium, Inflammation             |                                                          3               |      2  2.5|
      Pericardium, Inflammation            |    2        2                    3                             1         |      6  2.2|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   |                                                             3            |      2  2.5|
      Angiectasis                          |                      2                                                   |      1  2.0|
      Degeneration, Focal                  |                      1                                                   |      1  1.0|
      Hyperplasia                          |             2                                                            |      1  2.0|
      Hypertrophy                          |                   1  1                 2  1     2  1              1  1   |     15  1.1|
      Necrosis                             |                      1                                                   |      1  1.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                              1                           |      2  1.5|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                       2                  |      1  2.0|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  M  M  +  +  M  M  +  +  M  M  M  +  +  M  +  +  +  +  +  +  +  M|  30        |
      Amyloid Deposition                   |                                                             1            |      1  1.0|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M|  47        |
      Pars Distalis, Hyperplasia           |                                                                   1      |      1  1.0|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  48        |
      Amyloid Deposition                   |                                                             2            |      2  2.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |    2     2  2  2     4              2     2     4  2  2  2  3     2      |     21  2.4|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|  49        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 5| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 4|            |
                             DAY ON TEST   | 3| 6| 1| 0| 3| 3| 3| 3| 0| 0| 3| 8| 0| 0| 3| 3| 3| 3| 8| 8| 3| 6| 3| 3| 0|            |
                                           | 5| 2| 5| 0| 3| 4| 3| 4| 4| 5| 4| 7| 6| 0| 3| 4| 4| 5| 7| 7| 5| 2| 4| 3| 5|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.03                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  47        |

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                2                    2                 2     2        2  1|      9  1.7|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   1        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +|  48        |
      Foreign Body                         | 1  1  1  1  1  1  1  1  1  1  1  1     1     1  1  1     1  1  1  1  1  1|     43  1.0|
      Hyperplasia                          | 2  1        2  2  2  2  3  2  4  2     2     4  2        2     2  2  2  2|     36  2.3|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  M  M  M  +  M  +|  32        |
      Hyperplasia                          |                2              2                                          |      2  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  47        |
      Hyperplasia                          |                                              2                       2   |      2  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
      Foreign Body                         |    1  1  1  1  1     1  1        1  1  1     1  1     1  1     1        1|     24  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia                          | 2  3     2  3     3  2        4  2  2  3     3     2     2     2  3  3  2|     34  2.5|
      Artery, Inflammation                 |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   |                                                             3            |      2  3.0|
      Angiectasis                          |       1        2                                                         |      2  1.5|
      Hematopoietic Cell Proliferation     | 2  2        2     1  2  2     2  1     2     2  1  3  1        2  2  2  2|     34  2.0|
      Hyperplasia, Lymphoid                |                               2                                      2   |      3  2.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  M  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  M  +  +  +  +  M|  39        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   2        |

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                  3                                       |      1  3.0|
      Inflammation, Suppurative            |                                  2                                       |      1  2.0|
      Prepuce, Inflammation, Chronic Active|                               4                                          |      2  4.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Maxilla, Fracture                    |                                        X                                 |      1     |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 5| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 4|            |
                             DAY ON TEST   | 3| 6| 1| 0| 3| 3| 3| 3| 0| 0| 3| 8| 0| 0| 3| 3| 3| 3| 8| 8| 3| 6| 3| 3| 0|            |
                                           | 5| 2| 5| 0| 3| 4| 3| 4| 4| 5| 4| 7| 6| 0| 3| 4| 4| 5| 7| 7| 5| 2| 4| 3| 5|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.03                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                           1              1               |      3  1.0|
      Squamous Epithelium, Hyperplasia     |                            1                                             |      3  1.3|

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         | X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X   |     49  1.0|
      Hemorrhage                           |                                        4                                 |      1  4.0|
      Inflammation, Chronic Active         | 3  4  3  2  3  3  3  4  2  2  3  3  3  3  2  4  2  3  4  3  4  2  2  3  4|     50  2.9|
      Alveolar Epithelium, Hyperplasia     |             4        3                          1                        |      5  2.4|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                     3                                    |      1  3.0|
      Alveolus, Proteinosis                | 1           1     1  1  1                 1                       1  1   |     14  1.0|
      Artery, Mediastinum, Inflammation    |                               4                 4                        |      2  4.0|
      Interstitium, Fibrosis               |                                                       2  2               |      2  2.0|
      Serosa, Fibrosis                     | 3  4  4  4  4  3  3  2  3  3  3  4  4  4  4  4  3  3  4  4  3  3  4  4  3|     50  3.5|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                  X                                       |      1     |
      Hemorrhage                           |                                        4                                 |      1  4.0|
      Inflammation, Suppurative            |                                  2           1                           |      5  1.2|
      Olfactory Epithelium, Atrophy        |       1                                            1                     |      4  1.3|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |                               1                                          |      2  1.0|

                                            __________________________________________________________________________|____________|
   Pleura                                  | +     +     +     +  +  +        +        +  +        +  +           +   |  19        |
      Mesothelium, Hyperplasia             | 1     2     2     4  1  2        3        1  3        1  4           1   |     19  2.1|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|  46        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Degeneration                         |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   |                                                             3            |      2  3.0|
      Cyst                                 |          2                                                               |      1  2.0|
      Infiltration Cellular, Focal, Mixed  |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 5| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 4|            |
                             DAY ON TEST   | 3| 6| 1| 0| 3| 3| 3| 3| 0| 0| 3| 8| 0| 0| 3| 3| 3| 3| 8| 8| 3| 6| 3| 3| 0|            |
                                           | 5| 2| 5| 0| 3| 4| 3| 4| 4| 5| 4| 7| 6| 0| 3| 4| 4| 5| 7| 7| 5| 2| 4| 3| 5|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.03                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
          Cell                             |          1                                                               |      1  1.0|
      Nephropathy                          | 1  1  1  1  1  1  1  1  1     1  2  1     1  1  1  1  1  1  4  3  1  1  1|     40  1.4|
      Artery, Inflammation                 |                         2                 2  1                           |      5  1.8|
      Glomerulus, Inflammation, Chronic    |                                                                          |      1  3.0|
      Renal Tubule, Hyperplasia            |                                                                      1   |      2  1.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 6| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 6| 6| 5| 7| 7|             
                             DAY ON TEST   | 3| 2| 7| 3| 4| 9| 3| 3| 3| 5| 7| 3| 3| 5| 3| 8| 3| 3| 3| 7| 8| 8| 6| 3| 3|             
                                           | 3| 8| 8| 3| 4| 7| 4| 4| 4| 7| 8| 3| 4| 0| 5| 2| 3| 5| 3| 2| 1| 1| 2| 4| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.1MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     STOP                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Gallbladder                             | +  M  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  +  +|             
      Inflammation, Suppurative            |                                                 1                        |             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  M  +  +  A  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +|             
      Inflammation, Acute                  |                                  1                                       |             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +|             
      Artery, Inflammation                 |                                                                          |             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus, Multiple           |                                                    X                     |             
      Eosinophilic Focus                   |    X                             X                                   X   |             
      Eosinophilic Focus, Multiple         |          X              X                                               X|             
      Inflammation, Chronic Active         |                                              2                           |             
      Inflammation, Focal, Granulomatous   |          2                                                               |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                               4              1                           |             
      Vacuolization Cytoplasmic            |                                                                          |             

                                            __________________________________________________________________________|             
   Mesentery                               |                               +                          +        +      |             
      Artery, Inflammation                 |                                                                          |             
      Fat, Necrosis                        |                               3                          4        2      |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Atrophy                              |                                                                2         |             
      Artery, Inflammation                 |                   4                                                      |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Infiltration Cellular                |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                            1                                             |             
      Epithelium, Hyperplasia              | 2     1                                2                                 |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Infiltration Cellular                |                                                                          |             
      Inflammation, Suppurative            |                                        1                                 |             
      Necrosis, Focal                      |                                        1                                 |             
      Epithelium, Hyperplasia              |    4                                                                     |             

                                            __________________________________________________________________________|             
   Tooth                                   |                   +                                                      |             
      Inflammation                         |                   3                                                      |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 6| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 6| 6| 5| 7| 7|             
                             DAY ON TEST   | 3| 2| 7| 3| 4| 9| 3| 3| 3| 5| 7| 3| 3| 5| 3| 8| 3| 3| 3| 7| 8| 8| 6| 3| 3|             
                                           | 3| 8| 8| 3| 4| 7| 4| 4| 4| 7| 8| 3| 4| 0| 5| 2| 3| 5| 3| 2| 1| 1| 2| 4| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.1MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     STOP                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            |             +                                                            |             
      Inflammation                         |             2                                                            |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1     1  1     2  1  2  1  1  1  1  1  1  2  1  1  4     1     2  1  1|             
      Mineralization                       |                                              1                           |             
      Artery, Inflammation                 |                         3  1        2  2     1           1        3      |             
      Epicardium, Inflammation             |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Hyperplasia                          |                                     2              2                     |             
      Hypertrophy                          | 1  1                 2  1                 1     1  2           1     1  3|             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Hyperplasia                          |                                                    1                     |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  M  +  +  M  +  M  M  M  +  +  +  +  +  +  +  A  +  +  +  +  M|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  A  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                   1                                                      |             
      Pars Intermedia, Hyperplasia         |                                                                          |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                              1                           |             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |    4              2  2  2              2     2     3              4     3|             
      Inflammation                         |                            2                                             |             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                        1                                 |             
      Interstitial Cell, Hyperplasia       |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2                                               2                     |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                +         |             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Foreign Body                         | 1     1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1     1     1|             
      Hyperplasia                          |          2  2  2  1  2  1  2     2        2     2  2  2     2     2      |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 6| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 6| 6| 5| 7| 7|             
                             DAY ON TEST   | 3| 2| 7| 3| 4| 9| 3| 3| 3| 5| 7| 3| 3| 5| 3| 8| 3| 3| 3| 7| 8| 8| 6| 3| 3|             
                                           | 3| 8| 8| 3| 4| 7| 4| 4| 4| 7| 8| 3| 4| 0| 5| 2| 3| 5| 3| 2| 1| 1| 2| 4| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.1MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     STOP                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  M  +  +  +  M  M  +  +  +  +  M  +  +  +  M  +  M  M  +  +  +  +|             
      Hyperplasia                          |                                                 3                        |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                                  2                    2     2            |             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                  1  1        1           1  1            |             
      Hyperplasia                          |                2  1     2        3           2     3        2     2      |             
      Artery, Inflammation                 |                   1                                                      |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    3  1     2  2  2     2  2  2              1     2  3           2      |             
      Hyperplasia, Lymphoid                |                                                 2                        |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  M  M  +  +  M  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +|             
      Epithelial Cell, Hyperplasia         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3                                         3                           |             
      Inflammation, Suppurative            |    3                                         3                           |             
      Mineralization                       |                                        1                                 |             
      Ulcer                                |                                              3                           |             
      Prepuce, Inflammation, Chronic Active|    4                                                                     |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                               1                                          |             
      Maxilla, Fracture                    |                                              X                           |             

                                            __________________________________________________________________________|             
   Skeletal Muscle                         |       +                                                                  |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                         1                                                |             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Mononuclear Cell                |                   1                                                      |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Inflammation, Suppurative            |                                        1                                 |             
      Squamous Epithelium, Hyperplasia     |       2     1                                1                           |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         | X  X  X  X  X  X  X     X     X  X  X     X  X  X  X  X  X  X  X  X  X   |             
      Hemorrhage                           |                   1                                                      |             
      Inflammation, Chronic Active         | 2  1     1  1  2  1     2  2  1  2  1  1  1  1  1  2  2  2  2  1     1  2|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 6| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 6| 6| 5| 7| 7|             
                             DAY ON TEST   | 3| 2| 7| 3| 4| 9| 3| 3| 3| 5| 7| 3| 3| 5| 3| 8| 3| 3| 3| 7| 8| 8| 6| 3| 3|             
                                           | 3| 8| 8| 3| 4| 7| 4| 4| 4| 7| 8| 3| 4| 0| 5| 2| 3| 5| 3| 2| 1| 1| 2| 4| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.1MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     STOP                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                       2                  |             
      Artery, Mediastinum, Inflammation    |                         3                                                |             
      Serosa, Cyst                         |                                                             2            |             
      Serosa, Fibrosis                     | 2  2     3  1  2  1  1  2  3  1  2  1  2  1  2  2  2  2  2  3  2  3  1  2|             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                              3        1                  |             
      Olfactory Epithelium, Atrophy        | 1                                                                        |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |                                  1                                       |             

                                            __________________________________________________________________________|             
   Pleura                                  |          +                                                               |             
      Mesothelium, Hyperplasia             |          4                                                               |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Mineralization                       |                                              1                           |             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                                              +                           |             
      Degeneration                         |                                              4                           |             
      Cornea, Inflammation                 |                                                                          |             

                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                    +                     |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Infiltration Cellular, Mast Cell     |          2                                                               |             
      Metaplasia, Osseous                  |                                                                          |             
      Nephropathy                          | 1  1     2  2  1  2  2  1        1     2  1  2  1  1  1        1  1  1  1|             
      Artery, Inflammation                 |    1              2     2                                                |             
      Capsule, Hemorrhage                  |             4                                                            |             
      Renal Tubule, Hyperplasia            |                                                       2                  |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 4| 7| 6|            |
                             DAY ON TEST   | 6| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3| 3| 3| 6| 7| 8| 3| 3| 3| 3| 3| 9| 3| 2|            |
                                           | 4| 4| 4| 5| 7| 3| 3| 5| 5| 5| 3| 3| 4| 3| 9| 2| 1| 4| 3| 3| 4| 4| 1| 4| 5|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    0.1MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  A  +  +  +  +  A  +  +  M  +  +  +  M  +  +  +  +  +  +  +  A|  41        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic                |                                                                         2|      1  2.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Inflammation, Suppurative            |                                                                      2   |      1  2.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  A|  42        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Inflammation, Acute                  |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  43        |
      Artery, Inflammation                 |                                                                      2   |      1  2.0|

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                      X  X                                                |      2     |
      Clear Cell Focus, Multiple           |                                                                X         |      2     |
      Eosinophilic Focus                   |          X        X  X        X  X     X              X  X        X  X  X|     14     |
      Eosinophilic Focus, Multiple         |    X           X                                                         |      5     |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Inflammation, Focal, Granulomatous   |                                                                          |      1  2.0|
      Mixed Cell Focus                     |                                  X                                       |      1     |
      Necrosis                             |                                                                          |      2  2.5|
      Vacuolization Cytoplasmic            |                                                                         1|      1  1.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                             +                                    |   5        |
      Artery, Inflammation                 |                                     3                                    |      1  3.0|
      Fat, Necrosis                        |       2                                                                  |      4  2.8|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                               1                                          |      2  1.5|
      Artery, Inflammation                 |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Infiltration Cellular                |                   4                                                      |      1  4.0|
      Inflammation, Chronic                |                                              2                           |      1  2.0|
      Ulcer                                |             1                                   1                        |      3  1.0|
      Epithelium, Hyperplasia              |             2           2                    3  2     1                  |      8  1.9|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Infiltration Cellular                |                   4                                                      |      1  4.0|
      Inflammation, Suppurative            |                                                                         1|      2  1.0|
      Necrosis, Focal                      |                                                                          |      1  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 4| 7| 6|            |
                             DAY ON TEST   | 6| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3| 3| 3| 6| 7| 8| 3| 3| 3| 3| 3| 9| 3| 2|            |
                                           | 4| 4| 4| 5| 7| 3| 3| 5| 5| 5| 3| 3| 4| 3| 9| 2| 1| 4| 3| 3| 4| 4| 1| 4| 5|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    0.1MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Epithelium, Hyperplasia              |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |    1  1  1  1  1  1  1  1     2  1  1  1  1  2  1  1  1  1  1  1     1   |     42  1.2|
      Mineralization                       |             1                                                            |      2  1.0|
      Artery, Inflammation                 |    3  2                 3                                1     1  2     2|     14  1.9|
      Epicardium, Inflammation             |                                                                         3|      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                                                          |      2  2.0|
      Hypertrophy                          |       2  1     1  1  1        2  2     1     1     2     1  1  1         |     23  1.3|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                              1                           |      1  1.0|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |       2           1                                                      |      3  1.3|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  M  +  +  +  I  M  M  M  +  M  +  +  +  M  +  +|  34        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +|  45        |
      Pars Distalis, Hyperplasia           |                                                                          |      1  1.0|
      Pars Intermedia, Hyperplasia         |                                        2                                 |      1  2.0|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  47        |

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              | 2     3  3  2  2              2              2           2     2     3   |     19  2.5|
      Inflammation                         |                   3                                   3                  |      3  2.7|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 4| 7| 6|            |
                             DAY ON TEST   | 6| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3| 3| 3| 6| 7| 8| 3| 3| 3| 3| 3| 9| 3| 2|            |
                                           | 4| 4| 4| 5| 7| 3| 3| 5| 5| 5| 3| 3| 4| 3| 9| 2| 1| 4| 3| 3| 4| 4| 1| 4| 5|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    0.1MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Atrophy                              |                                  2                                       |      2  1.5|
      Interstitial Cell, Hyperplasia       |                                              2                           |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    2                    1                 3                          2   |      6  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   1        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +|  45        |
      Foreign Body                         | 1     1     1  1     1  1  1  1     1  1  1  1     1  1     1     1  1  1|     40  1.0|
      Hyperplasia                          | 3              2        2           2        3     1        4        2   |     22  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  M  +  +  M  M  +  +  M  M  M  +  M  I  +  +|  33        |
      Hyperplasia                          |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                            4                                             |      1  4.0|
      Hyperplasia                          | 3              2                    2     2              2           2  3|     10  2.2|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  M  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Foreign Body                         | 1  1  1           1                 1              1     1        1     1|     14  1.0|
      Hyperplasia                          | 2  2  3           2  2                             2     2     2        2|     17  2.1|
      Artery, Inflammation                 |                                     1                                    |      2  1.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hematopoietic Cell Proliferation     | 2  2     1  2                       2     4  3           2  1     2  1   |     23  2.0|
      Hyperplasia, Lymphoid                |       2  2                       2                                       |      4  2.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  M  A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  41        |
      Epithelial Cell, Hyperplasia         |       2                                                                  |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      2  3.0|
      Inflammation, Suppurative            |                                           4                              |      3  3.3|
      Mineralization                       |                                                                          |      1  1.0|
      Ulcer                                |                                                                          |      1  3.0|
      Prepuce, Inflammation, Chronic Active|    4                    1                                                |      3  3.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                       1                  |      2  1.0|
      Maxilla, Fracture                    |                                                                          |      1     |

                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 4| 7| 6|            |
                             DAY ON TEST   | 6| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3| 3| 3| 6| 7| 8| 3| 3| 3| 3| 3| 9| 3| 2|            |
                                           | 4| 4| 4| 5| 7| 3| 3| 5| 5| 5| 3| 3| 4| 3| 9| 2| 1| 4| 3| 3| 4| 4| 1| 4| 5|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    0.1MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration                         |                                                                          |      1  1.0|
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Mononuclear Cell                |    2                                                                     |      2  1.5|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Squamous Epithelium, Hyperplasia     |                                                                         1|      4  1.3|

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         | X  X  X     X  X  X     X  X  X     X  X  X  X  X  X  X  X     X  X  X  X|     42     |
      Hemorrhage                           |                                                             2            |      2  1.5|
      Inflammation, Chronic Active         | 2  2  1  2     1  2  1  2     2  2  2  2  2  1  1  1  2  2  1  2  2  2  2|     45  1.6|
      Alveolar Epithelium, Hyperplasia     |                4                                   2                     |      3  2.7|
      Artery, Mediastinum, Inflammation    |                                                                   4      |      2  3.5|
      Serosa, Cyst                         |                                                                          |      1  2.0|
      Serosa, Fibrosis                     | 3  2  1  2  4  1  3  1  2  2  2  2  2  2  2  2  2  1  2  2  3  2  3  2  3|     49  2.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                   1                       1                              |      4  1.5|
      Olfactory Epithelium, Atrophy        |                               1                                          |      2  1.0|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |                                        1     1                           |      3  1.0|

                                            __________________________________________________________________________|____________|
   Pleura                                  | +  +                                         +                           |   4        |
      Mesothelium, Hyperplasia             | 1  2                                         1                           |      4  2.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Mineralization                       |                                                                          |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                                           +           +                  |   3        |
      Degeneration                         |                                           4                              |      2  4.0|
      Cornea, Inflammation                 |                                                       1                  |      1  1.0|

                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                           +           +                  |   3        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Infiltration Cellular, Mast Cell     |                                                                          |      1  2.0|
      Metaplasia, Osseous                  |    2                                                  1                  |      2  1.5|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 4| 7| 6|            |
                             DAY ON TEST   | 6| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3| 3| 3| 6| 7| 8| 3| 3| 3| 3| 3| 9| 3| 2|            |
                                           | 4| 4| 4| 5| 7| 3| 3| 5| 5| 5| 3| 3| 4| 3| 9| 2| 1| 4| 3| 3| 4| 4| 1| 4| 5|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    0.1MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Nephropathy                          | 1  1  1  1  1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1     3   |     41  1.2|
      Artery, Inflammation                 |                                                          3  1     3      |      6  2.0|
      Capsule, Hemorrhage                  |                                                                   4      |      2  4.0|
      Renal Tubule, Hyperplasia            |          1        1                                                      |      3  1.3|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 7| 5| 7| 7| 7| 6| 7| 5| 7| 5| 6| 7| 7| 5| 7| 6| 5| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 1| 7| 6| 3| 6| 3| 3| 3| 3| 3| 9| 1| 8| 8| 2| 0| 8| 3| 0| 6| 3| 0| 3| 3|             
                                           | 4| 9| 1| 8| 3| 2| 4| 4| 3| 2| 3| 5| 5| 9| 7| 7| 6| 9| 3| 8| 2| 3| 1| 3| 4|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.3MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     STOP                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  A  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
      Degeneration, Hyaline                |                                     2                                    |             
      Inflammation, Chronic                |                                              3                           |             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Inflammation, Chronic                |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                   3      |             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Epithelium, Hyperplasia              |                      2                                                   |             
      Peyer's Patch, Hyperplasia           |                               1                                          |             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Eosinophilic Focus                   |             X        X           X           X     X           X     X   |             
      Eosinophilic Focus, Multiple         |                                                       X                  |             
      Mixed Cell Focus                     |                                           X                              |             
      Necrosis                             |       2                             2     2  2                    2      |             

                                            __________________________________________________________________________|             
   Mesentery                               |                                                          +  +     +     +|             
      Artery, Inflammation                 |                                                             3            |             
      Fat, Inflammation                    |                                                                          |             
      Fat, Necrosis                        |                                                                         2|             

                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                     1                                    |             
      Hypertrophy                          |                                                                      1   |             
      Duct, Cyst                           |                                                                          |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                  2                          2            |             
      Ulcer                                |          1                                                               |             
      Epithelium, Hyperplasia              |          2                       2                          2            |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                      2                       2                           |             
      Necrosis, Focal                      |                                     2                                    |             

                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Malformation                         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1        1  1     1  1  1  1  1     1  1  1  1  1     1        1     1  1|             
      Mineralization                       |                                                                          |             
      Artery, Inflammation                 |                   2     3                    2        2  1     2         |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 7| 5| 7| 7| 7| 6| 7| 5| 7| 5| 6| 7| 7| 5| 7| 6| 5| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 1| 7| 6| 3| 6| 3| 3| 3| 3| 3| 9| 1| 8| 8| 2| 0| 8| 3| 0| 6| 3| 0| 3| 3|             
                                           | 4| 9| 1| 8| 3| 2| 4| 4| 3| 2| 3| 5| 5| 9| 7| 7| 6| 9| 3| 8| 2| 3| 1| 3| 4|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.3MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     STOP                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Atrium, Inflammation, Chronic        |                                                 4                        |             
      Atrium, Metaplasia, Osseous          |                                                 3                        |             
      Atrium, Thrombosis                   |                                                 4                        |             
      Pericardium, Inflammation            |          2                    2                 3                        |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |                   1  1        1           1  1  1                    3  1|             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                1  1  1                                   2              2|             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   3  1                                                   |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  I  +  +  M  +  +  +  M  +  +  M  +  +  M  M  +  M  +  +  M  M  M  +  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Intermedia, Hyperplasia         |                         1                                                |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Peritoneum                              |                                                                   +      |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                              4                           |             
      Inflammation                         |                      1                                                   |             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              | 2           4        2  2     3     3     2  3                 2        2|             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                   2      |             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Congestion                           |                                                                          |             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                                                         2|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                          2               |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                +                                   +                     |             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         | 1  1  1     1     1  1  1  1  1  1  1  1  1  1  1     1  1  1  1  1  1   |             
      Hyperplasia                          |             2     1  1  2        2                    2  2  2  2         |             
      Artery, Inflammation                 |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 7| 5| 7| 7| 7| 6| 7| 5| 7| 5| 6| 7| 7| 5| 7| 6| 5| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 1| 7| 6| 3| 6| 3| 3| 3| 3| 3| 9| 1| 8| 8| 2| 0| 8| 3| 0| 6| 3| 0| 3| 3|             
                                           | 4| 9| 1| 8| 3| 2| 4| 4| 3| 2| 3| 5| 5| 9| 7| 7| 6| 9| 3| 8| 2| 3| 1| 3| 4|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.3MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     STOP                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  M  +  +  +  +  M  +  M  M  +  +  M  +  +  +  M  +  +  +  M  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  M  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2        2  2                                                |             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                      1        1        1  1           1     1  1     1  1|             
      Hematopoietic Cell Proliferation     |                                                          2               |             
      Hyperplasia                          |          2           2        2  2     2              2     2  2     2  4|             
      Infiltration Cellular, Histiocyte    |                                                 4                        |             
      Artery, Inflammation                 |                                                                          |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 3  2  2        3     2  2        2  2  2  2  2        2  2  2  2  2     1|             
      Hyperplasia, Lymphoid                |             2                                                           2|             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  M  +  +  M  M  +  M  +  +  +  M  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Prepuce, Inflammation, Chronic Active|    3                                                                     |             
      Subcutaneous Tissue, Edema           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                               2                                          |             

                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                  +                                +      |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                                          X               |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                      1   |             
      Squamous Epithelium, Hyperplasia     |       1                                            2              2      |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         | X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X|             
      Hemorrhage                           |          1                                            1                  |             
      Infiltration Cellular, Mast Cell     |                                                                          |             
      Inflammation, Chronic Active         | 2  2  1  3  3  3  2  2  2  2     3  2  4  2  2  2     1  2  2  2  1  3  2|             
      Alveolar Epithelium, Hyperplasia     |             2        1        1                                      1   |             
      Alveolus, Proteinosis                |                   1        1                    1                        |             
      Serosa, Fibrosis                     | 2  2  1  2  2  2  2  2  2  1  4  2  2  4  3  3  4  3  1  1  3  2  2  4  2|             
      Serosa, Metaplasia, Osseous          |                                                 1                        |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                               1                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 7| 5| 7| 7| 7| 6| 7| 5| 7| 5| 6| 7| 7| 5| 7| 6| 5| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 1| 7| 6| 3| 6| 3| 3| 3| 3| 3| 9| 1| 8| 8| 2| 0| 8| 3| 0| 6| 3| 0| 3| 3|             
                                           | 4| 9| 1| 8| 3| 2| 4| 4| 3| 2| 3| 5| 5| 9| 7| 7| 6| 9| 3| 8| 2| 3| 1| 3| 4|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.3MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     STOP                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Olfactory Epithelium, Atrophy        |                                                                          |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |       1                    1  1                          1               |             

                                            __________________________________________________________________________|             
   Pleura                                  |                   +  +                          +                    +   |             
      Mesothelium, Hyperplasia             |                   1  1                          4                    1   |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Inflammation                 |                                                                          |             

                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +                                                |             

                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                  +                                       |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                            2                                             |             
      Inflammation, Chronic Active         |       1                                                                 2|             
      Metaplasia, Osseous                  |                                                                          |             
      Nephropathy                          | 2        1  1  1  1  1  1     1     3  1  1  3  1  1  1  1  3  2     1  1|             
      Artery, Inflammation                 | 1                                                                        |             
      Capsule, Inflammation, Chronic       |                                                                          |             
      Renal Tubule, Hyperplasia            |                         1                                            1   |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |    2                                                                     |             
      Inflammation                         |       3                                                                  |             
      Transitional Epithelium, Hyperplasia |       3                                                                  |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 4| 7| 7|            |
                             DAY ON TEST   | 3| 4| 7| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 3| 3| 3| 6| 1| 3| 3| 3| 7| 3| 3|            |
                                           | 4| 5| 0| 4| 3| 4| 3| 5| 4| 3| 5| 5| 4| 8| 3| 4| 3| 4| 5| 3| 3| 3| 1| 4| 4|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    0.3MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  A  A  M  +  +  +  +  M  +  +  +  +  A  +  +  +  +  A  +  +  +  A  I  +|  38        |
      Degeneration, Hyaline                |                                                    2                     |      2  2.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  46        |
      Inflammation, Chronic                |    2                                                                     |      1  2.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  46        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  46        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +|  44        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +|  44        |
      Fibrosis                             |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +|  45        |
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
      Peyer's Patch, Hyperplasia           |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Eosinophilic Focus                   |                         X           X           X                        |     10     |
      Eosinophilic Focus, Multiple         | X           X              X                 X     X     X              X|      8     |
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis                             | 1                                                     3                  |      7  2.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               | +           +              +           +                                 |   8        |
      Artery, Inflammation                 |                                                                          |      1  3.0|
      Fat, Inflammation                    |             2                                                            |      1  2.0|
      Fat, Necrosis                        | 2                          2           2                                 |      4  2.0|

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                A         |            |

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  47        |
      Atrophy                              |                                     1                                    |      2  1.0|
      Hypertrophy                          |                                                                2         |      2  1.5|
      Duct, Cyst                           |                                                          4               |      1  4.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                          |      2  2.0|
      Ulcer                                |                                                                          |      1  1.0|
      Epithelium, Hyperplasia              |          4                             2                                 |      5  2.4|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  47        |
      Inflammation, Suppurative            |                                                                          |      2  2.0|
      Necrosis, Focal                      |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Tooth                                   |                   +                             +                        |   2        |
      Malformation                         |                   X                             X                        |      2     |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 4| 7| 7|            |
                             DAY ON TEST   | 3| 4| 7| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 3| 3| 3| 6| 1| 3| 3| 3| 7| 3| 3|            |
                                           | 4| 5| 0| 4| 3| 4| 3| 5| 4| 3| 5| 5| 4| 8| 3| 4| 3| 4| 5| 3| 3| 3| 1| 4| 4|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    0.3MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  1  2  1  1  1  1  1  1  1  1  1  1  1  1  2  1  1  1  1  1  1     1  1|     41  1.0|
      Mineralization                       |    1                                                                     |      1  1.0|
      Artery, Inflammation                 |       3              2                       2                    1      |     10  2.0|
      Atrium, Inflammation, Chronic        |                                                                          |      1  4.0|
      Atrium, Metaplasia, Osseous          |                                                                          |      1  3.0|
      Atrium, Thrombosis                   |                                                       2                  |      2  3.0|
      Pericardium, Inflammation            |                                                          2           2   |      5  2.2|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2                                                                        |      1  2.0|
      Hypertrophy                          |          1     1        1        1  1     1        1  1  2     1     1   |     19  1.2|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                      2   |      6  1.5|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  47        |
      Hyperplasia                          |                            2                          1                  |      4  1.8|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  M  +  +  +  +  M  +  M  M  +  +  +  +  M  +  +  +  +  +  +|  34        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Intermedia, Hyperplasia         |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |       2                                                                  |      2  3.0|
      Inflammation                         |                                                             1            |      2  1.0|

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  49        |
      Ectasia                              |                4  2  2     2  3  2  2     2              2     2         |     20  2.4|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Congestion                           |                      4                                                   |      1  4.0|

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |          1                                                     1         |      2  1.0|
      Inflammation, Granulomatous          |                                                             1            |      1  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 4| 7| 7|            |
                             DAY ON TEST   | 3| 4| 7| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 3| 3| 3| 6| 1| 3| 3| 3| 7| 3| 3|            |
                                           | 4| 5| 0| 4| 3| 4| 3| 5| 4| 3| 5| 5| 4| 8| 3| 4| 3| 4| 5| 3| 3| 3| 1| 4| 4|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    0.3MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Interstitial Cell, Hyperplasia       |                               1                                          |      2  1.5|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2                                         2        2                     |      4  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   2        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  48        |
      Foreign Body                         | 1  1  1        1        1  1  1     1  1  1  1  1  1     1  1  1  1  1  1|     40  1.0|
      Hyperplasia                          | 2  2     3     2        2  2        2        2  2  2     3     2        2|     22  2.0|
      Artery, Inflammation                 |                                     1                                    |      1  1.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  M  +  +  +  +  +  M  +  +  M  +  M  +  +  M  +  +  +|  36        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +|  45        |
      Hyperplasia                          |    4     2  2              2  2  2                                      2|     10  2.2|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Foreign Body                         | 1  1  1     1     1     1     1     1     1        1  1  1  1  1  1  1   |     25  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia                          |    2  2  2  2     2  2  2     3  4  3  2  2           2  2  2  2     2   |     27  2.2|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  4.0|
      Artery, Inflammation                 |                                                          2               |      1  2.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  48        |
      Hematopoietic Cell Proliferation     | 2     2  2  1           2  2  2     1     2  1  1     2                  |     29  1.9|
      Hyperplasia, Lymphoid                |                                                 2                        |      3  2.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  M  +  +  M  +  +  M  +  M  M  +  M  M  +  +  +  M  +  +  +  +  +|  35        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Prepuce, Inflammation, Chronic Active|             2        4                                                   |      3  3.0|
      Subcutaneous Tissue, Edema           |                                                             3            |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                2                                                         |      2  2.0|

                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Developmental Malformation           |                                                                          |      1     |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 4| 7| 7|            |
                             DAY ON TEST   | 3| 4| 7| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 3| 3| 3| 6| 1| 3| 3| 3| 7| 3| 3|            |
                                           | 4| 5| 0| 4| 3| 4| 3| 5| 4| 3| 5| 5| 4| 8| 3| 4| 3| 4| 5| 3| 3| 3| 1| 4| 4|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    0.3MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                   1                             1        1               |      4  1.0|
      Squamous Epithelium, Hyperplasia     |       2                                         2     2           1      |      7  1.7|

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         | X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X     X|     49     |
      Hemorrhage                           |                                                                          |      2  1.0|
      Infiltration Cellular, Mast Cell     | 4                                                                        |      1  4.0|
      Inflammation, Chronic Active         | 2  2  2  2  2  2  1  2  3  2  2  2  2  2  2  2  2  2  2  2     2     2  2|     46  2.1|
      Alveolar Epithelium, Hyperplasia     |                         4           2     4                              |      7  2.1|
      Alveolus, Proteinosis                |       1        1  1           1  1                          1     1      |     10  1.0|
      Serosa, Fibrosis                     | 3  4  3  3  2  2  1  4  3  3  1  1  3  4  2  3  3  2  3  4  2  2  1  3  2|     50  2.4|
      Serosa, Metaplasia, Osseous          |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                         1  1           1                             1   |      5  1.0|
      Olfactory Epithelium, Atrophy        |                            1                                             |      1  1.0|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |                                                                          |      4  1.0|

                                            __________________________________________________________________________|____________|
   Pleura                                  |          +                                               +               |   6        |
      Mesothelium, Hyperplasia             |          1                                               1               |      6  1.5|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  47        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                      +   |   1        |
      Cornea, Inflammation                 |                                                                      3   |      1  3.0|

                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                      +   |   2        |

                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   |                                                             4            |      2  3.0|
      Inflammation, Chronic Active         |                                                                          |      2  1.5|
      Metaplasia, Osseous                  |                                                                1         |      1  1.0|
      Nephropathy                          | 1  1     1  1  1  1  1  2  1  1  1  1     2  1  1  1  1  1     1     1  1|     41  1.2|
      Artery, Inflammation                 |                      2                                                   |      2  1.5|
      Capsule, Inflammation, Chronic       |                   2                                                      |      1  2.0|
      Renal Tubule, Hyperplasia            |                                              1  1                       1|      5  1.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  47        |
      Degeneration                         |                                                                          |      1  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:25:21  
                                                                                                                                    

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                                           | 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 4| 7| 7|            |
                             DAY ON TEST   | 3| 4| 7| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 3| 3| 3| 6| 1| 3| 3| 3| 7| 3| 3|            |
                                           | 4| 5| 0| 4| 3| 4| 3| 5| 4| 3| 5| 5| 4| 8| 3| 4| 3| 4| 5| 3| 3| 3| 1| 4| 4|      T (*) |

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                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    0.3MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

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 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation                         |                                                                          |      1  3.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|

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  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
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