NTP Experiment-Test: 00117-66               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: CHRONIC-LIFETIME                                    ASPARTAME                                         Date: 11/16/04
Route: DOSED FEED                                                                                                 Time: 08:27:20

       Facility:  Cancer Research Centre - Ramazzini Foundation

       Chemical CAS #:  22839-47-0

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All

a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1

NTP Experiment-Test: 00117-66               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: CHRONIC-LIFETIME                                    ASPARTAME                                         Date: 11/16/04  
Route: DOSED FEED                                                                                                 Time: 08:27:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 PPM        80 PPM       400 PPM      2000 PPM     10000        50000           
                                                                                                       PPM          PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                         150          150          150          150          100          100           
  Early Deaths                                                                                                                      
    Natural Death                                    150          150          150          150          100          100           
  Survivors                                                                                                                         
                                                                                                                                    
  Animals Examined Microscopically                   150          150          150          150          100          100           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (149)        (150)        (149)        (148)        (99)         (99)         
      Adenocarcinoma, Metastatic, Intestine Large,                                                                                  
           Colon                                                                              1 (1%)                                
      Adenocarcinoma, Metastatic, Adrenal Cortex       1 (1%)       2 (1%)       2 (1%)       1 (1%)                    2 (2%)      
      Cholangiocarcinoma                                                                                   1 (1%)       1 (1%)      
      Cholangioma                                                   1 (1%)       1 (1%)                                             
      Fibroangioma                                                                                         1 (1%)                   
      Fibrosarcoma, Metastatic, Peritoneum                                                    1 (1%)                                
      Hemangioma                                       1 (1%)                                                                       
      Hemangiosarcoma                                               1 (1%)                                                          
      Hepatocellular Carcinoma                                                   1 (1%)                                             
      Hepatocellular Adenoma                           2 (1%)       1 (1%)       1 (1%)                    1 (1%)       1 (1%)      
      Histiocytic Sarcoma                              3 (2%)       1 (1%)       3 (2%)                    2 (2%)       5 (5%)      
      Leukemia Granulocytic                                                                   1 (1%)                    1 (1%)      
      Leukemia Lymphocytic                                                       1 (1%)       1 (1%)                                
      Leukemia Monocytic                                            1 (1%)       4 (3%)       4 (3%)       2 (2%)       2 (2%)      
      Lymphoma Malignant                               1 (1%)       2 (1%)       1 (1%)       1 (1%)                    3 (3%)      
      Mesothelioma Malignant                                                                  1 (1%)                                
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                                           1 (1%)                    1 (1%)                                
      Bile Duct, Cholangioma                           2 (1%)                    1 (1%)                                             
   Stomach, Glandular                                              (1)                                                              
      Lymphoma Lymphocytic                                          1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 00117-66               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: CHRONIC-LIFETIME                                    ASPARTAME                                         Date: 11/16/04  
Route: DOSED FEED                                                                                                 Time: 08:27:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 PPM        80 PPM       400 PPM      2000 PPM     10000        50000           
                                                                                                       PPM          PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (150)        (148)        (149)        (150)        (100)        (97)         
      Fibroangioma                                                                                                      1 (1%)      
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                   1 (1%)                                             
      Axillary, Adenocarcinoma, Metastatic,                                                                                         
          Mammary Gland                                1 (1%)                                                                       
      Axillary, Histiocytic Sarcoma                    1 (1%)                                 1 (1%)       1 (1%)                   
      Axillary, Leukemia Monocytic                                               1 (1%)                    1 (1%)                   
      Axillary, Inguinal, Histiocytic Sarcoma                                                              1 (1%)                   
      Axillary, Inguinal, Liposarcoma, Metastatic,                                                                                  
           Mammary Gland                                                         1 (1%)                                             
      Axillary, Inguinal, Mediastinal, Leukemia                                                                                     
          Monocytic                                                                           1 (1%)                                
      Axillary, Inguinal, Mediastinal, Lymphoma                                                                                     
          Lymphocytic                                  1 (1%)                                                                       
      Axillary, Inguinal, Mediastinal, Lymphoma                                                                                     
          Lymphoblastic                                                          1 (1%)                                             
      Axillary, Inguinal, Mesenteric, Histiocytic                                                                                   
          Sarcoma                                                                2 (1%)       1 (1%)       1 (1%)       6 (6%)      
      Axillary, Inguinal, Mesenteric, Leukemia                                                                                      
          Lymphoblastic                                                                       1 (1%)                                
      Axillary, Inguinal, Mesenteric, Leukemia                                                                                      
          Monocytic                                                 1 (1%)       2 (1%)       1 (1%)       1 (1%)       2 (2%)      
      Axillary, Inguinal, Mesenteric, Leukemia                                                                                      
          Myeloid                                                                             1 (1%)                                
      Axillary, Inguinal, Mesenteric, Lymphoma                                                                                      
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 00117-66               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: CHRONIC-LIFETIME                                    ASPARTAME                                         Date: 11/16/04  
Route: DOSED FEED                                                                                                 Time: 08:27:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 PPM        80 PPM       400 PPM      2000 PPM     10000        50000           
                                                                                                       PPM          PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
          Lymphocytic                                               1 (1%)                                                          
      Axillary, Inguinal, Mesenteric, Lymphoma                                                                                      
          Lymphoblastic                                             1 (1%)       1 (1%)       2 (1%)                                
      Axillary, Inguinal, Mesenteric, Lymphoma                                                                                      
          Lympho-immunoblastic                         1 (1%)                                 1 (1%)                                
      Axillary, Inguinal, Mandibular, Lymphoma                                                                                      
          Lymphocytic                                                                                      1 (1%)                   
      Axillary, Mediastinal, Lymphoma Lymphoblastic    1 (1%)                                                                       
      Axillary, Mediastinal, Mesenteric,                                                                                            
          Histiocytic Sarcoma                                       1 (1%)                                                          
      Axillary, Mediastinal, Mesenteric, Lymphoma                                                                                   
          Lympho-immunoblastic                                                                1 (1%)                                
      Axillary, Mesenteric, Histiocytic Sarcoma                     2 (1%)                                                          
      Axillary, Mesenteric, Mandibular,                                                                                             
          Histiocytic Sarcoma                                                                 1 (1%)                                
      Deep Cervical, Mediastinal, Mandibular,                                                                                       
          Leukemia Lymphoblastic                                                              1 (1%)                                
      Iliac, Histiocytic Sarcoma                       1 (1%)                                                                       
      Inguinal, Fibroma                                                          1 (1%)                                             
      Inguinal, Histiocytic Sarcoma                    1 (1%)                                                                       
      Inguinal, Lymphoma Lympho-immunoblastic                                                                           1 (1%)      
      Inguinal, Renal, Mediastinal, Lymphoma                                                                                        
          Lympho-immunoblastic                                                   1 (1%)                                             
      Inguinal, Mesenteric, Leukemia Monocytic                                   1 (1%)                                             
      Inguinal, Mesenteric, Lymphoma                                                                                                
          Lympho-immunoblastic                                                                                          1 (1%)      
      Lumbar, Adenocarcinoma, Metastatic, Mammary                                                                                   
          Gland                                                                  1 (1%)                                             
      Lumbar, Histiocytic Sarcoma                                                                                       1 (1%)      
      Lumbar, Schwannoma Malignant, Metastatic,                                                                                     
           Uterus                                                                                          1 (1%)                   
      Mandibular, Liposarcoma, Metastatic, Tissue                                                                                   
          NOS                                          1 (1%)                                                                       
      Mandibular, Squamous Cell Carcinoma,                                                                                          
          Metastatic, Zymbal's Gland                                                          1 (1%)                    1 (1%)      
      Mandibular, Squamous Cell Carcinoma,                                                                                          
          Metastatic, Ear                              1 (1%)                                                                       
      Mediastinal, Adenocarcinoma, Metastatic,                                                                                      
           Adrenal Cortex                                                        1 (1%)                                             
      Mediastinal, Fibrosarcoma, Metastatic,                                                                                        
          Peritoneum                                                                          1 (1%)                                
      Mediastinal, Hemangioma                                                    1 (1%)                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 00117-66               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: CHRONIC-LIFETIME                                    ASPARTAME                                         Date: 11/16/04  
Route: DOSED FEED                                                                                                 Time: 08:27:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 PPM        80 PPM       400 PPM      2000 PPM     10000        50000           
                                                                                                       PPM          PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Mediastinal, Histiocytic Sarcoma                                                        1 (1%)       3 (3%)       1 (1%)      
      Mediastinal, Leukemia Monocytic                                            1 (1%)                                 1 (1%)      
      Mediastinal, Lymphoma Lymphocytic                1 (1%)       2 (1%)       2 (1%)       1 (1%)       2 (2%)                   
      Mediastinal, Lymphoma Lymphoblastic              1 (1%)       2 (1%)       4 (3%)       4 (3%)       1 (1%)       1 (1%)      
      Mediastinal, Lymphoma Lympho-immunoblastic       2 (1%)                    1 (1%)       1 (1%)       1 (1%)       1 (1%)      
      Mediastinal, Mesenteric, Histiocytic Sarcoma                               1 (1%)                                             
      Mediastinal, Mesenteric, Lymphoma                                                                                             
          Lymphoblastic                                                                                    1 (1%)       1 (1%)      
      Mediastinal, Mesenteric, Lymphoma                                                                                             
          Lympho-immunoblastic                                                                                          1 (1%)      
      Mediastinal, Mesenteric, Pancreatic,                                                                                          
          Leukemia Monocytic                                        1 (1%)                                                          
      Mediastinal, Mesenteric, Pancreatic,                                                                                          
          Lymphoma Lymphoblastic                                    1 (1%)                                                          
      Mediastinal, Mesenteric, Pancreatic,                                                                                          
          Lymphoma Lympho-immunoblastic                                                                                 1 (1%)      
      Mediastinal, Mesenteric, Mandibular,                                                                                          
          Histiocytic Sarcoma                          1 (1%)                                                                       
      Mediastinal, Pancreatic, Lymphoma Lymphocytic                 1 (1%)                                                          
      Mediastinal, Pancreatic, Lymphoma                                                                                             
          Lymphoblastic                                                                       1 (1%)                                
      Mediastinal, Pancreatic, Mandibular,                                                                                          
          Histiocytic Sarcoma                                                                                           1 (1%)      
      Mediastinal, Pancreatic, Mandibular,                                                                                          
          Leukemia Monocytic                                                                               1 (1%)                   
      Mediastinal, Pancreatic, Mandibular,                                                                                          
          Leukemia Myeloid                                                                    1 (1%)                                
      Mediastinal, Mandibular, Histiocytic Sarcoma                                                         1 (1%)                   
      Mediastinal, Mandibular, Leukemia Monocytic                   1 (1%)       1 (1%)                                 1 (1%)      
      Mesenteric, Fibroangioma                                      1 (1%)                                                          
      Mesenteric, Histiocytic Sarcoma                  1 (1%)                                              1 (1%)                   
      Mesenteric, Leukemia Monocytic                                                          2 (1%)                                
      Mesenteric, Lymphoma Lympho-immunoblastic                                  1 (1%)       1 (1%)                    1 (1%)      
      Mesenteric, Pancreatic, Leukemia Monocytic                                              1 (1%)                                
      Renal, Mediastinal, Histiocytic Sarcoma                                                                           1 (1%)      
      Renal, Mediastinal, Lymphoma Lymphoblastic                                 2 (1%)                                             
      Renal, Mediastinal, Mandibular, Histiocytic                                                                                   
          Sarcoma                                                                                                       1 (1%)      
   Spleen                                             (149)        (150)        (146)        (149)        (99)         (98)         
      Adenocarcinoma, Metastatic, Mammary Gland                                  1 (1%)                                             
      Adenocarcinoma, Metastatic, Adrenal Cortex                                 1 (1%)       1 (1%)                    1 (1%)      
      Fibroangioma                                                  1 (1%)                    1 (1%)       3 (3%)       4 (4%)      
      Fibroma                                                       1 (1%)       2 (1%)                    1 (1%)                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 00117-66               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: CHRONIC-LIFETIME                                    ASPARTAME                                         Date: 11/16/04  
Route: DOSED FEED                                                                                                 Time: 08:27:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 PPM        80 PPM       400 PPM      2000 PPM     10000        50000           
                                                                                                       PPM          PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Hemangiosarcoma                                  1 (1%)                                                                       
      Histiocytic Sarcoma                              3 (2%)       2 (1%)       5 (3%)       4 (3%)       7 (7%)       5 (5%)      
      Leukemia Lymphoblastic                                                                  1 (1%)                                
      Leukemia Monocytic                                            1 (1%)       5 (3%)       3 (2%)       1 (1%)       2 (2%)      
      Leukemia Myeloid                                                                        1 (1%)                    1 (1%)      
      Lymphoma Lymphocytic                                          3 (2%)                                                          
      Lymphoma Lymphoblastic                                        1 (1%)       2 (1%)       2 (1%)                    1 (1%)      
      Lymphoma Lympho-immunoblastic                    2 (1%)       1 (1%)       1 (1%)                                 2 (2%)      
      Mesothelioma Malignant                                                     1 (1%)       1 (1%)                                
   Thymus                                             (149)        (149)        (147)        (149)        (99)         (100)        
      Adenocarcinoma, Metastatic, Adrenal Cortex                                 1 (1%)                                             
      Histiocytic Sarcoma                              1 (1%)       1 (1%)       1 (1%)       1 (1%)       3 (3%)       4 (4%)      
      Leukemia Lymphoblastic                                                                  1 (1%)                                
      Leukemia Monocytic                                            2 (1%)       3 (2%)       1 (1%)       1 (1%)       2 (2%)      
      Leukemia Myeloid                                                                        1 (1%)                                
      Lymphoma Lymphocytic                             2 (1%)       3 (2%)       2 (1%)       1 (1%)       2 (2%)                   
      Lymphoma Lymphoblastic                           2 (1%)       3 (2%)       6 (4%)       6 (4%)       1 (1%)       2 (2%)      
      Lymphoma Lympho-immunoblastic                    2 (1%)                    2 (1%)       1 (1%)       1 (1%)       2 (2%)      
      Thymoma Benign                                   2 (1%)      10 (7%)       4 (3%)       6 (4%)       5 (5%)       4 (4%)      
      Thymoma Malignant                                             1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (150)        (150)        (150)        (150)        (100)        (100)        
      Glioma Malignant, Mixed                                                                 1 (1%)                    1 (1%)      
      Leukemia Lymphoblastic                                                                  1 (1%)                                
      Leukemia Myeloid                                                                        1 (1%)                                
      Lymphoma Lymphoblastic                                                     1 (1%)       1 (1%)                                
      Cerebellum, Meninges, Cerebrum, Leukemia                                                                                      
          Monocytic                                                 1 (1%)                                                          
      Cerebrum, Glioma Malignant, Mixed                             1 (1%)                                                          
      Cerebrum, Leukemia Monocytic                                                                         1 (1%)                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 00117-66               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: CHRONIC-LIFETIME                                    ASPARTAME                                         Date: 11/16/04  
Route: DOSED FEED                                                                                                 Time: 08:27:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 PPM        80 PPM       400 PPM      2000 PPM     10000        50000           
                                                                                                       PPM          PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NERVOUS SYSTEM - cont                                                                                                               
      Cerebrum, Oligodendroglioma NOS                               1 (1%)                                 1 (1%)                   
      Meninges, Leukemia Monocytic                                               2 (1%)                                             
      Meninges, Lymphoma Lympho-immunoblastic          1 (1%)                                 1 (1%)                    1 (1%)      
      Meninges, Neoplasm NOS                                        1 (1%)       2 (1%)       2 (1%)       2 (2%)       1 (1%)      
      Meninges, Squamous Cell Carcinoma,                                                                                            
          Metastatic, Ear                              1 (1%)                                                                       
      Meninges, Cerebrum, Lymphoma                                                                                                  
          Lympho-immunoblastic                         1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (149)        (150)        (148)        (149)        (99)         (99)         
      Adenocarcinoma, Metastatic, Mammary Gland                     2 (1%)       2 (1%)       1 (1%)       1 (1%)       1 (1%)      
      Adenocarcinoma, Metastatic, Adrenal Cortex                                 1 (1%)                                 2 (2%)      
      Adenoma                                                                    1 (1%)                                             
      Alveolar/Bronchiolar Adenoma                                                            3 (2%)                                
      Fibroangioma                                                                            2 (1%)                                
      Fibrosarcoma                                                                                                      1 (1%)      
      Histiocytic Sarcoma                              1 (1%)       3 (2%)       2 (1%)       3 (2%)       6 (6%)       6 (6%)      
      Leukemia Lymphoblastic                                                                  1 (1%)                                
      Leukemia Monocytic                                            2 (1%)       5 (3%)       1 (1%)       1 (1%)       2 (2%)      
      Leukemia Myeloid                                                                        1 (1%)                                
      Liposarcoma, Metastatic, Mammary Gland                                     1 (1%)                                             
      Liposarcoma, Metastatic, Uncertain Primary                                                                                    
          Site                                                                                                          1 (1%)      
      Lymphoma Lymphocytic                                          1 (1%)                                                          
      Lymphoma Lymphoblastic                           1 (1%)                    2 (1%)       2 (1%)       1 (1%)                   
      Lymphoma Lympho-immunoblastic                    5 (3%)       5 (3%)       8 (5%)       6 (4%)       1 (1%)       7 (7%)      
      Osteosarcoma                                                                                         1 (1%)                   
      Osteosarcoma, Metastatic, Bone                   1 (1%)                    1 (1%)                                             
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                   1 (1%)                                             
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                                           2 (1%)                                 1 (1%)                   
      Seminoma Malignant, Metastatic, Uterus                                                               1 (1%)                   
      Squamous Cell Carcinoma                                                    2 (1%)                                 1 (1%)      
      Alveolus, Adenoma                                                                                    1 (1%)                   
      Bronchiole, Adenoma                                                                                               1 (1%)      
      Bronchus, Adenoma                                                                                                 1 (1%)      
   Pleura                                             (139)        (148)        (145)        (148)        (96)         (96)         
      Adenocarcinoma, Metastatic, Adrenal Cortex                                 1 (1%)                                             
      Leukemia Lymphoblastic                                                                  1 (1%)                                
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 00117-66               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: CHRONIC-LIFETIME                                    ASPARTAME                                         Date: 11/16/04  
Route: DOSED FEED                                                                                                 Time: 08:27:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 PPM        80 PPM       400 PPM      2000 PPM     10000        50000           
                                                                                                       PPM          PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Leukemia Monocytic                                            2 (1%)                                              1 (1%)      
      Leukemia Myeloid                                                                        1 (1%)                                
      Lymphoma Lymphocytic                                          1 (1%)                                                          
      Lymphoma Lymphoblastic                                                                  1 (1%)                                
      Lymphoma Lympho-immunoblastic                                 3 (2%)                                              1 (1%)      
      Neoplasm NOS                                                                            1 (1%)       2 (2%)       1 (1%)      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(150)       *(150)       *(150)       *(150)       *(100)       *(100)        
      Histiocytic Sarcoma                              3 (2%)       5 (3%)       8 (5%)       7 (5%)      11 (11%)      7 (7%)      
      Leukemia Granulocytic                                                                   1 (1%)                    1 (1%)      
      Leukemia Lymphoblastic                                                                  1 (1%)                                
      Leukemia Lymphocytic                                                       1 (1%)       1 (1%)                                
      Leukemia Monocytic                                            2 (1%)       5 (3%)       4 (3%)       2 (2%)       2 (2%)      
      Leukemia Myeloid                                                                        1 (1%)                    1 (1%)      
      Lymphoma Lympho-immunoblastic                    5 (3%)       5 (3%)       8 (5%)       8 (5%)       2 (2%)      11 (11%)     
      Lymphoma Lymphoblastic                           2 (1%)       3 (2%)       7 (5%)       6 (4%)       2 (2%)       2 (2%)      
      Lymphoma Lymphocytic                             2 (1%)       5 (3%)       2 (1%)       1 (1%)       2 (2%)                   
      Lymphoma Malignant                               1 (1%)       2 (1%)       1 (1%)       1 (1%)                    3 (3%)      
      Mesothelioma Malignant                                                     1 (1%)       2 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 00117-66               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: CHRONIC-LIFETIME                                    ASPARTAME                                         Date: 11/16/04  
Route: DOSED FEED                                                                                                 Time: 08:27:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 PPM        80 PPM       400 PPM      2000 PPM     10000        50000           
                                                                                                       PPM          PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            20          36          44          39          31          35               
     Total Primary Neoplasms                           21          42          50          49          38          45               
                                                                                                                                    
   Total Animals with Benign Neoplasms                  7          14          12          11          10          12               
     Total Benign Neoplasms                             7          15          12          12          12          12               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              13          22          34          28          20          26               
     Total Malignant Neoplasms                         14          24          36          33          21          30               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5           7           7           6           3           6               
     Total Metastatic Neoplasm                          6           7          16           8           4           8               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                       1                                   1               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              3           2           4           5           3               
     Total Uncertain Neoplasms                                      3           2           4           5           3               
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 00117-66               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: CHRONIC-LIFETIME                                    ASPARTAME                                         Date: 11/16/04  
Route: DOSED FEED                                                                                                 Time: 08:27:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                100000                                                                           
                                                   PPM                                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                         100                                                                            
  Early Deaths                                                                                                                      
    Natural Death                                    100                                                                            
  Survivors                                                                                                                         
                                                                                                                                    
  Animals Examined Microscopically                   100                                                                            
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (99)                                                                          
      Cholangioma                                      4 (4%)                                                                       
      Histiocytic Sarcoma                              2 (2%)                                                                       
      Leukemia Granulocytic                            2 (2%)                                                                       
      Leukemia Monocytic                               2 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 00117-66               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: CHRONIC-LIFETIME                                    ASPARTAME                                         Date: 11/16/04  
Route: DOSED FEED                                                                                                 Time: 08:27:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                100000                                                                           
                                                   PPM                                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (99)                                                                          
      Axillary, Inguinal, Mesenteric, Leukemia                                                                                      
          Monocytic                                    1 (1%)                                                                       
      Axillary, Inguinal, Mesenteric, Leukemia                                                                                      
          Myeloid                                      1 (1%)                                                                       
      Axillary, Mediastinal, Mesenteric, Leukemia                                                                                   
          Myeloid                                      1 (1%)                                                                       
      Iliac, Schwannoma Malignant, Metastatic,                                                                                      
           Uterus                                      1 (1%)                                                                       
      Inguinal, Mediastinal, Mesenteric,                                                                                            
          Histiocytic Sarcoma                          1 (1%)                                                                       
      Mediastinal, Leukemia Monocytic                  1 (1%)                                                                       
      Mediastinal, Lymphoma Lymphoblastic              1 (1%)                                                                       
      Mediastinal, Lymphoma Lympho-immunoblastic       1 (1%)                                                                       
      Mediastinal, Mesenteric, Histiocytic Sarcoma     1 (1%)                                                                       
      Mediastinal, Mandibular, Leukemia Myeloid        1 (1%)                                                                       
      Mesenteric, Leukemia Monocytic                   1 (1%)                                                                       
      Renal, Histiocytic Sarcoma                       1 (1%)                                                                       
   Spleen                                             (100)                                                                         
      Fibroangioma                                     2 (2%)                                                                       
      Histiocytic Sarcoma                              1 (1%)                                                                       
      Leukemia Monocytic                               2 (2%)                                                                       
      Leukemia Myeloid                                 2 (2%)                                                                       
   Thymus                                             (99)                                                                          
      Histiocytic Sarcoma                              1 (1%)                                                                       
      Leukemia Monocytic                               1 (1%)                                                                       
      Leukemia Myeloid                                 2 (2%)                                                                       
      Lymphoma Lymphocytic                             2 (2%)                                                                       
      Lymphoma Lymphoblastic                           1 (1%)                                                                       
      Lymphoma Lympho-immunoblastic                    1 (1%)                                                                       
      Thymoma Benign                                   2 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 00117-66               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: CHRONIC-LIFETIME                                    ASPARTAME                                         Date: 11/16/04  
Route: DOSED FEED                                                                                                 Time: 08:27:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                100000                                                                           
                                                   PPM                                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (100)                                                                         
      Cerebellum, Oligodendroglioma NOS                1 (1%)                                                                       
      Cerebrum, Lymphoma Lympho-immunoblastic          1 (1%)                                                                       
      Meninges, Leukemia Monocytic                     1 (1%)                                                                       
      Meninges, Leukemia Myeloid                       1 (1%)                                                                       
      Meninges, Lymphoma Lympho-immunoblastic          1 (1%)                                                                       
      Meninges, Neoplasm NOS                           1 (1%)                                                                       
      Meninges, Cerebrum, Lymphoma                                                                                                  
          Lympho-immunoblastic                         1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (100)                                                                         
      Adenoma                                          1 (1%)                                                                       
      Histiocytic Sarcoma                              3 (3%)                                                                       
      Leukemia Monocytic                               1 (1%)                                                                       
      Leukemia Myeloid                                 2 (2%)                                                                       
      Lymphoma Lympho-immunoblastic                   11 (11%)                                                                      
      Squamous Cell Carcinoma, Metastatic, Oral                                                                                     
          Mucosa                                       1 (1%)                                                                       
   Pleura                                             (98)                                                                          
      Leukemia Myeloid                                 1 (1%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 00117-66               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: CHRONIC-LIFETIME                                    ASPARTAME                                         Date: 11/16/04  
Route: DOSED FEED                                                                                                 Time: 08:27:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                100000                                                                           
                                                   PPM                                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(100)                                                                         
      Histiocytic Sarcoma                              3 (3%)                                                                       
      Leukemia Granulocytic                            2 (2%)                                                                       
      Leukemia Monocytic                               2 (2%)                                                                       
      Leukemia Myeloid                                 2 (2%)                                                                       
      Lymphoma Lympho-immunoblastic                   11 (11%)                                                                      
      Lymphoma Lymphoblastic                           1 (1%)                                                                       
      Lymphoma Lymphocytic                             2 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 00117-66               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: CHRONIC-LIFETIME                                    ASPARTAME                                         Date: 11/16/04  
Route: DOSED FEED                                                                                                 Time: 08:27:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                100000                                                                           
                                                   PPM                                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            30                                                                           
     Total Primary Neoplasms                           34                                                                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                  8                                                                           
     Total Benign Neoplasms                             9                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              21                                                                           
     Total Malignant Neoplasms                         23                                                                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                                                                           
     Total Metastatic Neoplasm                          2                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  2                                                                           
     Total Uncertain Neoplasms                          2                                                                           
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 00117-66               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: CHRONIC-LIFETIME                                    ASPARTAME                                         Date: 11/16/04  
Route: DOSED FEED                                                                                                 Time: 08:27:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS MALE                  0 PPM        80 PPM       400 PPM      2000 PPM     10000        50000           
                                                                                                       PPM          PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                         150          150          150          150          100          100           
  Early Deaths                                                                                                                      
    Natural Death                                    150          150          150          150          100          100           
  Survivors                                                                                                                         
                                                                                                                                    
  Animals Examined Microscopically                   150          149          150          150          100          100           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (148)        (148)        (149)        (148)        (100)        (100)        
      Adenocarcinoma, Metastatic, Adrenal Cortex       1 (1%)                                                                       
      Cholangioma                                                                4 (3%)       2 (1%)       3 (3%)       1 (1%)      
      Hemangiosarcoma                                                                                                   1 (1%)      
      Hemangiosarcoma, Metastatic, Spleen              1 (1%)                                                                       
      Hepatocellular Carcinoma                                                                2 (1%)                                
      Hepatocellular Adenoma                                                                  1 (1%)       1 (1%)       1 (1%)      
      Histiocytic Sarcoma                              6 (4%)       2 (1%)                    3 (2%)       2 (2%)       1 (1%)      
      Leukemia Granulocytic                            1 (1%)       2 (1%)                                 1 (1%)                   
      Leukemia Lymphocytic                                                                                 1 (1%)                   
      Leukemia Monocytic                               2 (1%)       2 (1%)       1 (1%)       7 (5%)       2 (2%)       1 (1%)      
      Lymphoma Malignant                               2 (1%)                                 2 (1%)       1 (1%)       1 (1%)      
      Osteosarcoma, Metastatic, Bone                   1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Pituitary Gland                                    (1)                                                                           
      Adenocarcinoma                                   1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 00117-66               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: CHRONIC-LIFETIME                                    ASPARTAME                                         Date: 11/16/04  
Route: DOSED FEED                                                                                                 Time: 08:27:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS MALE                  0 PPM        80 PPM       400 PPM      2000 PPM     10000        50000           
                                                                                                       PPM          PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                                                           
      Mediastinum, Lymphoma Lympho-immunoblastic       1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (1)                                                                           
      Leukemia Myeloid                                 1 (100%)                                                                     
   Lymph Node                                         (149)        (148)        (149)        (150)        (99)         (100)        
      Histiocytic Sarcoma                                                                     1 (1%)                                
      Lymphoma Lymphoblastic                                        1 (1%)                                                          
      Lymphoma Lympho-immunoblastic                    1 (1%)                                 2 (1%)                                
      Axillary, Histiocytic Sarcoma                                                                        1 (1%)                   
      Axillary, Leukemia Monocytic                                                            1 (1%)                                
      Axillary, Lymphoma Lympho-immunoblastic                                                 1 (1%)                                
      Axillary, Inguinal, Histiocytic Sarcoma                                                 1 (1%)                                
      Axillary, Inguinal, Lymphoma                                                                                                  
          Lympho-immunoblastic                                                                             1 (1%)                   
      Axillary, Inguinal, Mediastinal, Leukemia                                                                                     
          Monocytic                                                                           1 (1%)                                
      Axillary, Inguinal, Mediastinal, Lymphoma                                                                                     
          Lympho-immunoblastic                                                                1 (1%)                                
      Axillary, Inguinal, Mesenteric, Histiocytic                                                                                   
          Sarcoma                                      1 (1%)                                 1 (1%)                    1 (1%)      
      Axillary, Inguinal, Mesenteric, Leukemia                                                                                      
          Lymphoblastic                                                                                    1 (1%)                   
      Axillary, Inguinal, Mesenteric, Leukemia                                                                                      
          Monocytic                                                              1 (1%)       1 (1%)       2 (2%)                   
      Axillary, Inguinal, Mesenteric, Leukemia                                                                                      
          Myeloid                                                   2 (1%)                                 1 (1%)                   
      Axillary, Inguinal, Mesenteric, Lymphoma                                                                                      
          Lympho-immunoblastic                                                                             1 (1%)       2 (2%)      
      Axillary, Inguinal, Mandibular, Histiocytic                                                                                   
          Sarcoma                                      1 (1%)                                                                       
      Axillary, Mediastinal, Histiocytic Sarcoma                    1 (1%)                                                          
      Axillary, Mediastinal, Leukemia Monocytic                     1 (1%)                                                          
      Axillary, Mesenteric, Leukemia Monocytic                      1 (1%)                                              1 (1%)      
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 00117-66               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: CHRONIC-LIFETIME                                    ASPARTAME                                         Date: 11/16/04  
Route: DOSED FEED                                                                                                 Time: 08:27:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS MALE                  0 PPM        80 PPM       400 PPM      2000 PPM     10000        50000           
                                                                                                       PPM          PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Axillary, Mesenteric, Mandibular, Leukemia                                                                                    
          Monocytic                                                                           1 (1%)                                
      Iliac, Leukemia Monocytic                                                               1 (1%)                                
      Inguinal, Fibroangioma                                                                                            1 (1%)      
      Inguinal, Histiocytic Sarcoma                                 1 (1%)                    1 (1%)                                
      Inguinal, Mediastinal, Leukemia Monocytic                                               1 (1%)                                
      Inguinal, Mesenteric, Histiocytic Sarcoma        1 (1%)                                                                       
      Inguinal, Mandibular, Lymphoma                                                                                                
          Lympho-immunoblastic                                                                             1 (1%)                   
      Lumbar, Histiocytic Sarcoma                      1 (1%)                                                                       
      Mandibular, Histiocytic Sarcoma                  1 (1%)                                 1 (1%)                                
      Mandibular, Leukemia Monocytic                                                                       2 (2%)                   
      Mandibular, Lymphoma Lympho-immunoblastic        1 (1%)                                                                       
      Mediastinal, Adenocarcinoma, Metastatic,                                                                                      
           Seminal Vesicle                                                       1 (1%)                                             
      Mediastinal, Histiocytic Sarcoma                                                        4 (3%)                                
      Mediastinal, Leukemia Monocytic                                                         2 (1%)                                
      Mediastinal, Lymphoma Lymphocytic                                                       1 (1%)                                
      Mediastinal, Lymphoma Lympho-immunoblastic       1 (1%)       1 (1%)       2 (1%)                    2 (2%)       4 (4%)      
      Mediastinal, Squamous Cell Carcinoma,                                                                                         
          Metastatic, Zymbal's Gland                                                                                    1 (1%)      
      Mediastinal, Mesenteric, Lymphoma                                                                                             
          Lympho-immunoblastic                         1 (1%)                    1 (1%)                                 1 (1%)      
      Mediastinal, Mesenteric, Pancreatic,                                                                                          
          Histiocytic Sarcoma                                                                              1 (1%)                   
      Mediastinal, Mesenteric, Pancreatic,                                                                                          
          Leukemia Lymphoblastic                       1 (1%)                                                                       
      Mediastinal, Mesenteric, Mandibular,                                                                                          
          Histiocytic Sarcoma                          1 (1%)                                 1 (1%)                                
      Mediastinal, Pancreatic, Mandibular,                                                                                          
          Histiocytic Sarcoma                                                                                           1 (1%)      
      Mediastinal, Pancreatic, Mandibular,                                                                                          
          Leukemia Monocytic                                                                                            1 (1%)      
      Mediastinal, Pancreatic, Mandibular,                                                                                          
          Leukemia Myeloid                                          1 (1%)                                 1 (1%)                   
      Mediastinal, Mandibular, Leukemia                                                                                             
          Lymphoblastic                                                                                    1 (1%)                   
      Mediastinal, Mandibular, Leukemia Monocytic                                1 (1%)                                             
      Mediastinal, Mandibular, Leukemia Myeloid                     1 (1%)                                                          
      Mediastinal, Mandibular, Lymphoma                                                                                             
          Lympho-immunoblastic                                                                             1 (1%)       3 (3%)      
      Mesenteric, Fibroangioma                                                                             2 (2%)                   
      Mesenteric, Histiocytic Sarcoma                  2 (1%)       1 (1%)       1 (1%)       1 (1%)                    1 (1%)      
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  17                                                               
                                                                                                                                   
NTP Experiment-Test: 00117-66               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: CHRONIC-LIFETIME                                    ASPARTAME                                         Date: 11/16/04  
Route: DOSED FEED                                                                                                 Time: 08:27:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS MALE                  0 PPM        80 PPM       400 PPM      2000 PPM     10000        50000           
                                                                                                       PPM          PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Mesenteric, Leukemia Monocytic                                                          1 (1%)                                
      Mesenteric, Lymphoma Lympho-immunoblastic                     1 (1%)       2 (1%)       2 (1%)                    2 (2%)      
      Mesenteric, Pancreatic, Leiomyosarcoma,                                                                                       
          Metastatic, Intestine Large, Colon           1 (1%)                                                                       
      Pancreatic, Histiocytic Sarcoma                                                         1 (1%)                                
      Pancreatic, Leukemia Myeloid                     1 (1%)                                                                       
      Pancreatic, Lymphoma Lympho-immunoblastic        1 (1%)                                                                       
      Renal, Pheochromocytoma Malignant,                                                                                            
          Metastatic, Adrenal Medulla                                                                                   1 (1%)      
      Renal, Mediastinal, Lymphoma                                                                                                  
          Lympho-immunoblastic                                                                1 (1%)                                
   Spleen                                             (147)        (147)        (146)        (149)        (99)         (100)        
      Fibroangioma                                                               1 (1%)                    1 (1%)       2 (2%)      
      Fibroma                                                                    1 (1%)                    1 (1%)                   
      Fibrosarcoma                                                                                                      1 (1%)      
      Hemangiosarcoma                                  1 (1%)                                 2 (1%)                                
      Histiocytic Sarcoma                              1 (1%)                                 3 (2%)       1 (1%)       3 (3%)      
      Leukemia Lymphoblastic                           1 (1%)                                              1 (1%)                   
      Leukemia Monocytic                                            2 (1%)       1 (1%)       6 (4%)       2 (2%)       1 (1%)      
      Leukemia Myeloid                                 1 (1%)       2 (1%)                                 1 (1%)                   
      Lymphoma Lympho-immunoblastic                                 1 (1%)       2 (1%)       4 (3%)       2 (2%)       6 (6%)      
   Thymus                                             (146)        (147)        (142)        (148)        (98)         (98)         
      Adenocarcinoma, Metastatic, Seminal Vesicle                                1 (1%)                                             
      Fibroangioma                                                               1 (1%)       1 (1%)                                
      Histiocytic Sarcoma                              1 (1%)       2 (1%)                    5 (3%)       1 (1%)       1 (1%)      
      Leukemia Lymphoblastic                           1 (1%)                                              1 (1%)                   
      Leukemia Monocytic                                            1 (1%)       1 (1%)       4 (3%)                                
      Leukemia Myeloid                                              2 (1%)                                 1 (1%)                   
      Lymphoma Lymphocytic                                                                    1 (1%)                                
      Lymphoma Lymphoblastic                                        1 (1%)                                                          
      Lymphoma Lympho-immunoblastic                    2 (1%)       1 (1%)       3 (2%)       2 (1%)       2 (2%)       7 (7%)      
      Thymoma Benign                                                1 (1%)                                                          
      Thymoma Malignant                                1 (1%)       1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  18                                                               
                                                                                                                                   
NTP Experiment-Test: 00117-66               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: CHRONIC-LIFETIME                                    ASPARTAME                                         Date: 11/16/04  
Route: DOSED FEED                                                                                                 Time: 08:27:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS MALE                  0 PPM        80 PPM       400 PPM      2000 PPM     10000        50000           
                                                                                                       PPM          PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (150)        (149)        (149)        (148)        (100)        (99)         
      Leukemia Myeloid                                              2 (1%)                                                          
      Lymphoma Lympho-immunoblastic                                                           1 (1%)                                
      Neoplasm NOS                                                               2 (1%)       2 (1%)                    2 (2%)      
      Oligodendroglioma NOS                                                                   1 (1%)                    1 (1%)      
      Cerebrum, Astrocytoma NOS                                                                            1 (1%)                   
      Cerebrum, Oligodendroglioma NOS                               2 (1%)                                              1 (1%)      
      Meninges, Lymphoma Lympho-immunoblastic                                                 1 (1%)                    1 (1%)      
      Meninges, Neoplasm NOS                           2 (1%)       1 (1%)       1 (1%)       1 (1%)       3 (3%)       3 (3%)      
      Meninges, Cerebrum, Lymphoma                                                                                                  
          Lympho-immunoblastic                         1 (1%)                                                                       
      Meninges, Cerebrum, Lymphoma Malignant                                                                                        
          Lymphocytic                                  1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (150)        (149)        (149)        (149)        (100)        (100)        
      Adenocarcinoma, Metastatic, Seminal Vesicle                                1 (1%)                                             
      Adenoma                                                                                                           1 (1%)      
      Alveolar/Bronchiolar Adenoma                                                            1 (1%)                                
      Fibroangioma                                                  1 (1%)                                              1 (1%)      
      Fibroma                                                                    1 (1%)                                             
      Fibrous Histiocytoma                                          1 (1%)                                                          
      Hemangiosarcoma                                                                                                   1 (1%)      
      Hemangiosarcoma, Metastatic, Liver                                                                                1 (1%)      
      Histiocytic Sarcoma                              2 (1%)       2 (1%)       1 (1%)       7 (5%)       2 (2%)       4 (4%)      
      Leukemia Lymphoblastic                           1 (1%)                                                                       
      Leukemia Monocytic                               1 (1%)       2 (1%)       1 (1%)       7 (5%)       2 (2%)       1 (1%)      
      Leukemia Myeloid                                              2 (1%)                                 1 (1%)                   
      Lymphoma Lymphoblastic                                        2 (1%)                                                          
      Lymphoma Lympho-immunoblastic                   19 (13%)     12 (8%)      21 (14%)     14 (9%)       7 (7%)      10 (10%)     
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                      1 (1%)                                                          
      Osteosarcoma, Metastatic, Ear                                 1 (1%)                                                          
      Squamous Cell Carcinoma                                       1 (1%)                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  19                                                               
                                                                                                                                   
NTP Experiment-Test: 00117-66               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: CHRONIC-LIFETIME                                    ASPARTAME                                         Date: 11/16/04  
Route: DOSED FEED                                                                                                 Time: 08:27:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS MALE                  0 PPM        80 PPM       400 PPM      2000 PPM     10000        50000           
                                                                                                       PPM          PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Squamous Cell Carcinoma, Metastatic,                                                                                          
          Zymbal's Gland                                                                                                1 (1%)      
      Bronchus, Squamous Cell Carcinoma                                          1 (1%)                                             
   Pleura                                             (149)        (147)        (148)        (148)        (100)        (100)        
      Leukemia Monocytic                                                                      1 (1%)                                
      Leukemia Myeloid                                              1 (1%)                                                          
      Lymphoma Lympho-immunoblastic                                 1 (1%)       1 (1%)       4 (3%)                    2 (2%)      
      Neoplasm NOS                                                                            1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                                                                     (1)          
      Histiocytic Sarcoma                                                                                               1 (100%)    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(150)       *(149)       *(150)       *(150)       *(100)       *(100)        
      Histiocytic Sarcoma                              8 (5%)       4 (3%)       2 (1%)      10 (7%)       3 (3%)       7 (7%)      
      Leukemia Granulocytic                            1 (1%)       2 (1%)                                 1 (1%)                   
      Leukemia Lymphoblastic                           1 (1%)                                              1 (1%)                   
      Leukemia Lymphocytic                                                                                 1 (1%)                   
      Leukemia Monocytic                               2 (1%)       2 (1%)       1 (1%)       8 (5%)       2 (2%)       1 (1%)      
      Leukemia Myeloid                                 1 (1%)       2 (1%)                                 1 (1%)                   
      Lymphoma Lympho-immunoblastic                   19 (13%)     13 (9%)      22 (15%)     15 (10%)      8 (8%)      13 (13%)     
      Lymphoma Lymphoblastic                                        3 (2%)                                                          
      Lymphoma Lymphocytic                                                                    1 (1%)                                
      Lymphoma Malignant                               2 (1%)                                 2 (1%)       1 (1%)       1 (1%)      
      Lymphoma Malignant Lymphocytic                   1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  20                                                               
                                                                                                                                   
NTP Experiment-Test: 00117-66               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: CHRONIC-LIFETIME                                    ASPARTAME                                         Date: 11/16/04  
Route: DOSED FEED                                                                                                 Time: 08:27:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS MALE                  0 PPM        80 PPM       400 PPM      2000 PPM     10000        50000           
                                                                                                       PPM          PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            36          31          35          43          24          37               
     Total Primary Neoplasms                           40          34          37          50          30          39               
                                                                                                                                    
   Total Animals with Benign Neoplasms                              2           8           5           7           7               
     Total Benign Neoplasms                                         2           8           5           8           7               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              34          26          26          37          15          24               
     Total Malignant Neoplasms                         38          29          26          40          18          25               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4           2           1                                   3               
     Total Metastatic Neoplasm                          4           2           3                                   4               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  2           3           3           5           4           7               
     Total Uncertain Neoplasms                          2           3           3           5           4           7               
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  21                                                               
                                                                                                                                   
NTP Experiment-Test: 00117-66               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: CHRONIC-LIFETIME                                    ASPARTAME                                         Date: 11/16/04  
Route: DOSED FEED                                                                                                 Time: 08:27:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS MALE                  100000                                                                           
                                                   PPM                                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                         100                                                                            
  Early Deaths                                                                                                                      
    Natural Death                                    100                                                                            
  Survivors                                                                                                                         
                                                                                                                                    
  Animals Examined Microscopically                   100                                                                            
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (100)                                                                         
      Cholangiocarcinoma                               1 (1%)                                                                       
      Fibrosarcoma, Metastatic, Tissue NOS             1 (1%)                                                                       
      Hepatocellular Carcinoma                         1 (1%)                                                                       
      Histiocytic Sarcoma                              3 (3%)                                                                       
      Leukemia Granulocytic                            1 (1%)                                                                       
      Leukemia Monocytic                               1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  22                                                               
                                                                                                                                   
NTP Experiment-Test: 00117-66               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: CHRONIC-LIFETIME                                    ASPARTAME                                         Date: 11/16/04  
Route: DOSED FEED                                                                                                 Time: 08:27:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS MALE                  100000                                                                           
                                                   PPM                                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (100)                                                                         
      Axillary, Lymphoma Lympho-immunoblastic          1 (1%)                                                                       
      Axillary, Inguinal, Mesenteric, Leukemia                                                                                      
          Myeloid                                      1 (1%)                                                                       
      Axillary, Mediastinal, Mesenteric, Lymphoma                                                                                   
          Lympho-immunoblastic                         1 (1%)                                                                       
      Lumbar, Mediastinal, Mandibular, Lymphoma                                                                                     
          Lympho-immunoblastic                         1 (1%)                                                                       
      Mandibular, Schwannoma Malignant, Metastatic,                                                                                 
           Peripheral Nerve                            2 (2%)                                                                       
      Mandibular, Squamous Cell Carcinoma,                                                                                          
          Metastatic, Ear                              1 (1%)                                                                       
      Mediastinal, Lymphoma Lympho-immunoblastic       5 (5%)                                                                       
      Mediastinal, Mesenteric, Histiocytic Sarcoma     1 (1%)                                                                       
      Mediastinal, Pancreatic, Lymphoma                                                                                             
          Lympho-immunoblastic                         1 (1%)                                                                       
      Mediastinal, Mandibular, Leukemia Myeloid        1 (1%)                                                                       
      Pancreatic, Histiocytic Sarcoma                  1 (1%)                                                                       
   Spleen                                             (99)                                                                          
      Fibroangioma                                     4 (4%)                                                                       
      Hemangiosarcoma                                  2 (2%)                                                                       
      Histiocytic Sarcoma                              1 (1%)                                                                       
      Leukemia Monocytic                               1 (1%)                                                                       
      Leukemia Myeloid                                 1 (1%)                                                                       
      Lymphoma Lympho-immunoblastic                    2 (2%)                                                                       
   Thymus                                             (94)                                                                          
      Leukemia Monocytic                               1 (1%)                                                                       
      Leukemia Myeloid                                 1 (1%)                                                                       
      Lymphoma Lympho-immunoblastic                    7 (7%)                                                                       
      Thymoma Malignant                                1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  23                                                               
                                                                                                                                   
NTP Experiment-Test: 00117-66               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: CHRONIC-LIFETIME                                    ASPARTAME                                         Date: 11/16/04  
Route: DOSED FEED                                                                                                 Time: 08:27:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS MALE                  100000                                                                           
                                                   PPM                                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (99)                                                                          
      Leukemia Myeloid                                 1 (1%)                                                                       
      Cerebrum, Lymphoma Malignant Lymphocytic         1 (1%)                                                                       
      Cerebrum, Oligodendroglioma NOS                  2 (2%)                                                                       
      Meninges, Neoplasm NOS                           1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (100)                                                                         
      Fibrosarcoma, Metastatic, Tissue NOS             1 (1%)                                                                       
      Hemangiosarcoma                                  1 (1%)                                                                       
      Histiocytic Sarcoma                              2 (2%)                                                                       
      Leukemia Monocytic                               1 (1%)                                                                       
      Leukemia Myeloid                                 1 (1%)                                                                       
      Lymphoma Lympho-immunoblastic                   23 (23%)                                                                      
      Bronchus, Adenoma                                1 (1%)                                                                       
   Pleura                                             (98)                                                                          
      Leukemia Monocytic                               1 (1%)                                                                       
      Leukemia Myeloid                                 1 (1%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(100)                                                                         
      Histiocytic Sarcoma                              4 (4%)                                                                       
      Leukemia Granulocytic                            1 (1%)                                                                       
      Leukemia Monocytic                               1 (1%)                                                                       
      Leukemia Myeloid                                 1 (1%)                                                                       
      Lymphoma Lympho-immunoblastic                   24 (24%)                                                                      
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  24                                                               
                                                                                                                                   
NTP Experiment-Test: 00117-66               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: CHRONIC-LIFETIME                                    ASPARTAME                                         Date: 11/16/04  
Route: DOSED FEED                                                                                                 Time: 08:27:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS MALE                  100000                                                                           
                                                   PPM                                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            
                                                                                                                                    
   Multiple Organs                                   *(100)                                                                         
      Lymphoma Malignant Lymphocytic                   1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  25                                                               
                                                                                                                                   
NTP Experiment-Test: 00117-66               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: CHRONIC-LIFETIME                                    ASPARTAME                                         Date: 11/16/04  
Route: DOSED FEED                                                                                                 Time: 08:27:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS MALE                  100000                                                                           
                                                   PPM                                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            39                                                                           
     Total Primary Neoplasms                           46                                                                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                  5                                                                           
     Total Benign Neoplasms                             5                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              34                                                                           
     Total Malignant Neoplasms                         38                                                                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4                                                                           
     Total Metastatic Neoplasm                          5                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  3                                                                           
     Total Uncertain Neoplasms                          3                                                                           
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  26                                                               
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------