NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  103-90-2

       Lock Date:  09/30/03

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All

                                                              Page   1

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 1                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 1
ANIMAL NUM: 125               DOSE: 0 MG/KG 6 HR                 DISP: Terminal Sacrifice                       HISTO: 0203112
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
  * Kidney                          Liver Lft Lobe                  Liver Med Lobe

    * PROTOCOL REQUIRED TISSUE
__________________________________________________________________________________________________________________________________

                                                             Page   2

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 1                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 1
ANIMAL NUM: 126               DOSE: 0 MG/KG 6 HR                 DISP: Terminal Sacrifice                       HISTO: 0203113
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
  * Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   3

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 1                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 1
ANIMAL NUM: 127               DOSE: 0 MG/KG 6 HR                 DISP: Terminal Sacrifice                       HISTO: 0203114
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
  * Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   4

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 1                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 1
ANIMAL NUM: 137               DOSE: 0 MG/KG 6 HR                 DISP: Terminal Sacrifice                       HISTO: 0203124
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
  * Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   5

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 1                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 1
ANIMAL NUM: 138               DOSE: 0 MG/KG 6 HR                 DISP: Terminal Sacrifice                       HISTO: 0203125
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
  * Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   6

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 1                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 1
ANIMAL NUM: 139               DOSE: 0 MG/KG 6 HR                 DISP: Terminal Sacrifice                       HISTO: 0203126
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
  * Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   7

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 2                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 128               DOSE: 0 MG/KG 18 HR                DISP: Terminal Sacrifice                       HISTO: 0203115
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
  * Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   8

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 2                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 129               DOSE: 0 MG/KG 18 HR                DISP: Terminal Sacrifice                       HISTO: 0203116
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
  * Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   9

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 2                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 130               DOSE: 0 MG/KG 18 HR                DISP: Terminal Sacrifice                       HISTO: 0203117
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
  * Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   10

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 2                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 140               DOSE: 0 MG/KG 18 HR                DISP: Terminal Sacrifice                       HISTO: 0203127
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
  * Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   11

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 2                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 141               DOSE: 0 MG/KG 18 HR                DISP: Terminal Sacrifice                       HISTO: 0203128
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
  * Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   12

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 2                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 142               DOSE: 0 MG/KG 18 HR                DISP: Terminal Sacrifice                       HISTO: 0203129
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
  * Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   13

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 3                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 131               DOSE: 0 MG/KG 24 HR                DISP: Terminal Sacrifice                       HISTO: 0203118
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
  * Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   14

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 3                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 132               DOSE: 0 MG/KG 24 HR                DISP: Terminal Sacrifice                       HISTO: 0203119
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
  * Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   15

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 3                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 133               DOSE: 0 MG/KG 24 HR                DISP: Terminal Sacrifice                       HISTO: 0203120
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
  * Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   16

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 3                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 143               DOSE: 0 MG/KG 24 HR                DISP: Terminal Sacrifice                       HISTO: 0203130
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
  * Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   17

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 3                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 144               DOSE: 0 MG/KG 24 HR                DISP: Terminal Sacrifice                       HISTO: 0203131
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
  * Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   18

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 3                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 145               DOSE: 0 MG/KG 24 HR                DISP: Terminal Sacrifice                       HISTO: 0203132
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
  * Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   19

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 4                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 3
ANIMAL NUM: 134               DOSE: 0 MG/KG 48 HR                DISP: Terminal Sacrifice                       HISTO: 0203121
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
  * Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   20

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 4                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 3
ANIMAL NUM: 135               DOSE: 0 MG/KG 48 HR                DISP: Terminal Sacrifice                       HISTO: 0203122
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
  * Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   21

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 4                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 3
ANIMAL NUM: 136               DOSE: 0 MG/KG 48 HR                DISP: Terminal Sacrifice                       HISTO: 0203123
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
  * Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   22

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 4                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 3
ANIMAL NUM: 146               DOSE: 0 MG/KG 48 HR                DISP: Terminal Sacrifice                       HISTO: 0203133
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
  * Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   23

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 4                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 3
ANIMAL NUM: 147               DOSE: 0 MG/KG 48 HR                DISP: Terminal Sacrifice                       HISTO: 0203134
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
  * Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   24

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 4                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 3
ANIMAL NUM: 148               DOSE: 0 MG/KG 48 HR                DISP: Terminal Sacrifice                       HISTO: 0203135
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
  * Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   25

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 5                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 1
ANIMAL NUM: 225               DOSE: 50 MG/KG6 HR                 DISP: Terminal Sacrifice                       HISTO: 0203136
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
  * Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   26

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 5                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 1
ANIMAL NUM: 226               DOSE: 50 MG/KG6 HR                 DISP: Terminal Sacrifice                       HISTO: 0203137
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
  * Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   27

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 5                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 1
ANIMAL NUM: 227               DOSE: 50 MG/KG6 HR                 DISP: Terminal Sacrifice                       HISTO: 0203138
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
  * Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   28

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 5                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 1
ANIMAL NUM: 237               DOSE: 50 MG/KG6 HR                 DISP: Terminal Sacrifice                       HISTO: 0203148
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
  * Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   29

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 5                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 1
ANIMAL NUM: 238               DOSE: 50 MG/KG6 HR                 DISP: Terminal Sacrifice                       HISTO: 0203149
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
  * Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   30

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 5                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 1
ANIMAL NUM: 239               DOSE: 50 MG/KG6 HR                 DISP: Terminal Sacrifice                       HISTO: 0203150
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
  * Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   31

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 6                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 228               DOSE: 50 MG/KG18 HR                DISP: Terminal Sacrifice                       HISTO: 0203139
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   32

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 6                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 229               DOSE: 50 MG/KG18 HR                DISP: Terminal Sacrifice                       HISTO: 0203140
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   33

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 6                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 230               DOSE: 50 MG/KG18 HR                DISP: Terminal Sacrifice                       HISTO: 0203141
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   34

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 6                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 240               DOSE: 50 MG/KG18 HR                DISP: Terminal Sacrifice                       HISTO: 0203151
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   35

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 6                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 241               DOSE: 50 MG/KG18 HR                DISP: Terminal Sacrifice                       HISTO: 0203152
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   36

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 6                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 242               DOSE: 50 MG/KG18 HR                DISP: Terminal Sacrifice                       HISTO: 0203153
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   37

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 7                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 231               DOSE: 50 MG/KG24 HR                DISP: Terminal Sacrifice                       HISTO: 0203142
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   38

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 7                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 232               DOSE: 50 MG/KG24 HR                DISP: Terminal Sacrifice                       HISTO: 0203143
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   39

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 7                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 233               DOSE: 50 MG/KG24 HR                DISP: Terminal Sacrifice                       HISTO: 0203144
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   40

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 7                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 243               DOSE: 50 MG/KG24 HR                DISP: Terminal Sacrifice                       HISTO: 0203154
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   41

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 7                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 244               DOSE: 50 MG/KG24 HR                DISP: Terminal Sacrifice                       HISTO: 0203155
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   42

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 7                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 245               DOSE: 50 MG/KG24 HR                DISP: Terminal Sacrifice                       HISTO: 0203156
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   43

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 8                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 3
ANIMAL NUM: 234               DOSE: 50 MG/KG48 HR                DISP: Terminal Sacrifice                       HISTO: 0203145
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   44

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 8                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 3
ANIMAL NUM: 235               DOSE: 50 MG/KG48 HR                DISP: Terminal Sacrifice                       HISTO: 0203146
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   45

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 8                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 3
ANIMAL NUM: 236               DOSE: 50 MG/KG48 HR                DISP: Terminal Sacrifice                       HISTO: 0203147
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   46

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 8                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 3
ANIMAL NUM: 246               DOSE: 50 MG/KG48 HR                DISP: Terminal Sacrifice                       HISTO: 0203157
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   47

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 8                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 3
ANIMAL NUM: 247               DOSE: 50 MG/KG48 HR                DISP: Terminal Sacrifice                       HISTO: 0203158
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   48

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 8                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 3
ANIMAL NUM: 248               DOSE: 50 MG/KG48 HR                DISP: Terminal Sacrifice                       HISTO: 0203159
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   49

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 9                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 1
ANIMAL NUM: 325               DOSE: 150MG/KG6HR                  DISP: Terminal Sacrifice                       HISTO: 0203160
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   50

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 9                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 1
ANIMAL NUM: 326               DOSE: 150MG/KG6HR                  DISP: Terminal Sacrifice                       HISTO: 0203161
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   51

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 9                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 1
ANIMAL NUM: 327               DOSE: 150MG/KG6HR                  DISP: Terminal Sacrifice                       HISTO: 0203162
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   52

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 9                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 1
ANIMAL NUM: 337               DOSE: 150MG/KG6HR                  DISP: Terminal Sacrifice                       HISTO: 0203172
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   53

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 9                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 1
ANIMAL NUM: 338               DOSE: 150MG/KG6HR                  DISP: Terminal Sacrifice                       HISTO: 0203173
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   54

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 9                     SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 1
ANIMAL NUM: 339               DOSE: 150MG/KG6HR                  DISP: Terminal Sacrifice                       HISTO: 0203174
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   55

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 10                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 328               DOSE: 150MG/KG18 HR                DISP: Terminal Sacrifice                       HISTO: 0203163
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   56

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 10                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 329               DOSE: 150MG/KG18 HR                DISP: Terminal Sacrifice                       HISTO: 0203164
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   57

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 10                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 330               DOSE: 150MG/KG18 HR                DISP: Terminal Sacrifice                       HISTO: 0203165
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   58

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 10                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 340               DOSE: 150MG/KG18 HR                DISP: Terminal Sacrifice                       HISTO: 0203175
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   59

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 10                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 341               DOSE: 150MG/KG18 HR                DISP: Terminal Sacrifice                       HISTO: 0203176
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   60

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 10                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 342               DOSE: 150MG/KG18 HR                DISP: Terminal Sacrifice                       HISTO: 0203177
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   61

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 11                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 331               DOSE: 150MG/KG24 HR                DISP: Terminal Sacrifice                       HISTO: 0203166
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   62

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 11                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 332               DOSE: 150MG/KG24 HR                DISP: Terminal Sacrifice                       HISTO: 0203167
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   63

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 11                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 333               DOSE: 150MG/KG24 HR                DISP: Terminal Sacrifice                       HISTO: 0203168
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   64

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 11                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 343               DOSE: 150MG/KG24 HR                DISP: Terminal Sacrifice                       HISTO: 0203178
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   65

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 11                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 344               DOSE: 150MG/KG24 HR                DISP: Terminal Sacrifice                       HISTO: 0203179
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   66

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 11                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 345               DOSE: 150MG/KG24 HR                DISP: Terminal Sacrifice                       HISTO: 0203180
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   67

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 12                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 3
ANIMAL NUM: 334               DOSE: 150MG/KG48 HR                DISP: Terminal Sacrifice                       HISTO: 0203169
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   68

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 12                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 3
ANIMAL NUM: 335               DOSE: 150MG/KG48 HR                DISP: Terminal Sacrifice                       HISTO: 0203170
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   69

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 12                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 3
ANIMAL NUM: 336               DOSE: 150MG/KG48 HR                DISP: Terminal Sacrifice                       HISTO: 0203171
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   70

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 12                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 3
ANIMAL NUM: 346               DOSE: 150MG/KG48 HR                DISP: Terminal Sacrifice                       HISTO: 0203181
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   71

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 12                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 3
ANIMAL NUM: 347               DOSE: 150MG/KG48 HR                DISP: Terminal Sacrifice                       HISTO: 0203182
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   72

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 12                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 3
ANIMAL NUM: 348               DOSE: 150MG/KG48 HR                DISP: Terminal Sacrifice                       HISTO: 0203183
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   73

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 13                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 1
ANIMAL NUM: 425               DOSE: 1500MG/K6 HR                 DISP: Terminal Sacrifice                       HISTO: 0203184
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   74

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 13                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 1
ANIMAL NUM: 426               DOSE: 1500MG/K6 HR                 DISP: Terminal Sacrifice                       HISTO: 0203185
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   75

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 13                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 1
ANIMAL NUM: 427               DOSE: 1500MG/K6 HR                 DISP: Terminal Sacrifice                       HISTO: 0203186
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Liver Lft Lobe - Centrilobular                  Necrosis          Minimal

    Liver Med Lobe - Centrilobular                  Necrosis          Minimal

__________________________________________________________________________________________________________________________________

                                                             Page   76

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 13                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 1
ANIMAL NUM: 437               DOSE: 1500MG/K6 HR                 DISP: Terminal Sacrifice                       HISTO: 0203196
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   77

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 13                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 1
ANIMAL NUM: 438               DOSE: 1500MG/K6 HR                 DISP: Terminal Sacrifice                       HISTO: 0203197
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   78

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 13                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 1
ANIMAL NUM: 439               DOSE: 1500MG/K6 HR                 DISP: Terminal Sacrifice                       HISTO: 0203198
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Liver Med Lobe - Centrilobular                  Necrosis          Minimal

__________________________________________________________________________________________________________________________________

                                                             Page   79

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 14                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 428               DOSE: 1500MG/K18 HR                DISP: Terminal Sacrifice                       HISTO: 0203187
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   80

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 14                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 429               DOSE: 1500MG/K18 HR                DISP: Terminal Sacrifice                       HISTO: 0203188
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   81

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 14                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 430               DOSE: 1500MG/K18 HR                DISP: Terminal Sacrifice                       HISTO: 0203189
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Liver Lft Lobe - Centrilobular                  Necrosis          Moderate
                   - Hepatocyte                     Degen             Minimal
                   - Sinusoid                       Congestion        Moderate
                  [ Necrosis           TGLs = 1-1 ]

    Liver Med Lobe - Centrilobular                  Necrosis          Moderate
                   - Hepatocyte                     Degen             Minimal
                   - Sinusoid                       Congestion        Moderate
                  [ Necrosis           TGLs = 1-2 ]

__________________________________________________________________________________________________________________________________

                                                             Page   82

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 14                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 440               DOSE: 1500MG/K18 HR                DISP: Terminal Sacrifice                       HISTO: 0203199
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Liver Lft Lobe - Centrilobular                  Necrosis          Minimal

    Liver Med Lobe - Centrilobular                  Necrosis          Mild
                   - Sinusoid                       Congestion        Mild
                  [ Necrosis           TGLs = 1-2 ]

__________________________________________________________________________________________________________________________________

                                                             Page   83

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 14                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 441               DOSE: 1500MG/K18 HR                DISP: Terminal Sacrifice                       HISTO: 0203200
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Liver Lft Lobe - Centrilobular                  Necrosis          Mild
                   - Sinusoid                       Congestion        Mild
                  [ Necrosis           TGLs = 1-1 ]

    Liver Med Lobe - Centrilobular                  Necrosis          Mild
                   - Sinusoid                       Congestion        Mild
                  [ Necrosis           TGLs = 1-2 ]

__________________________________________________________________________________________________________________________________

                                                             Page   84

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 14                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 442               DOSE: 1500MG/K18 HR                DISP: Terminal Sacrifice                       HISTO: 0203201
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Liver Lft Lobe - Centrilobular                  Necrosis          Minimal

    Liver Med Lobe - Centrilobular                  Necrosis          Minimal

__________________________________________________________________________________________________________________________________

                                                             Page   85

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 15                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 431               DOSE: 1500MG/K24 HR                DISP: Terminal Sacrifice                       HISTO: 0203190
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Liver Lft Lobe - Centrilobular                  Necrosis          Mild
                   - Sinusoid                       Congestion        Mild

    Liver Med Lobe - Centrilobular                  Necrosis          Moderate
                   - Sinusoid                       Congestion        Moderate

__________________________________________________________________________________________________________________________________

                                                             Page   86

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 15                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 432               DOSE: 1500MG/K24 HR                DISP: Terminal Sacrifice                       HISTO: 0203191
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Liver Lft Lobe - Centrilobular                  Necrosis          Moderate
                   - Sinusoid                       Congestion        Moderate
                  [ Necrosis           TGLs = 1-1 ]

    Liver Med Lobe - Centrilobular                  Necrosis          Moderate
                   - Sinusoid                       Congestion        Moderate
                  [ Necrosis           TGLs = 1-2 ]

__________________________________________________________________________________________________________________________________

                                                             Page   87

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 15                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 433               DOSE: 1500MG/K24 HR                DISP: Terminal Sacrifice                       HISTO: 0203192
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Liver Lft Lobe - Centrilobular                  Necrosis          Moderate
                   - Sinusoid                       Congestion        Moderate

    Liver Med Lobe - Centrilobular                  Necrosis          Moderate
                   - Sinusoid                       Congestion        Moderate

__________________________________________________________________________________________________________________________________

                                                             Page   88

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 15                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 443               DOSE: 1500MG/K24 HR                DISP: Terminal Sacrifice                       HISTO: 0203202
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Kidney - Renal Tubule                           Necrosis          Mild

    Liver Lft Lobe - Centrilobular                  Necrosis          Mild
                   - Hepatocyte                     Hypertrophy       Mild
                   - Sinusoid                       Congestion        Mild
                  [ Necrosis           TGLs = 2,3-1 ]

    Liver Med Lobe - Centrilobular                  Necrosis          Mild
                   - Hepatocyte                     Hypertrophy       Mild
                   - Sinusoid                       Congestion        Mild
                  [ Necrosis           TGLs = 2,3-2 ]

__________________________________________________________________________________________________________________________________

                                                             Page   89

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 15                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 444               DOSE: 1500MG/K24 HR                DISP: Terminal Sacrifice                       HISTO: 0203203
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Liver Lft Lobe - Centrilobular                  Necrosis          Moderate
                   - Hepatocyte                     Hypertrophy       Minimal
                   - Sinusoid                       Congestion        Moderate
                  [ Necrosis           TGLs = 1-1 ]

    Liver Med Lobe - Centrilobular                  Necrosis          Moderate
                   - Hepatocyte                     Hypertrophy       Minimal
                   - Sinusoid                       Congestion        Moderate
                  [ Necrosis           TGLs = 1-2 ]

__________________________________________________________________________________________________________________________________

                                                             Page   90

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 15                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 445               DOSE: 1500MG/K24 HR                DISP: Terminal Sacrifice                       HISTO: 0203204
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Liver Lft Lobe - Centrilobular                  Necrosis          Moderate
                   - Hepatocyte                     Hypertrophy       Minimal
                   - Sinusoid                       Congestion        Moderate
                  [ Necrosis           TGLs = 1,2-1 ]

    Liver Med Lobe - Centrilobular                  Necrosis          Moderate
                   - Hepatocyte                     Hypertrophy       Minimal
                   - Sinusoid                       Congestion        Moderate
                  [ Necrosis           TGLs = 1,2-2 ]

__________________________________________________________________________________________________________________________________

                                                             Page   91

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 16                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 3
ANIMAL NUM: 434               DOSE: 1500MG/K48 HR                DISP: Terminal Sacrifice                       HISTO: 0203193
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Kidney - Renal Tubule                           Necrosis          Minimal

    Liver Lft Lobe - Centrilobular                  Infiltrat Cell    Mild, Mononuclear Cl
                   - Centrilobular                  Necrosis          Mild
                   - Hepatocyte                     Degen             Minimal
                   - Hepatocyte                     Regeneration      Mild
                   - Sinusoid                       Congestion        Minimal

    Liver Med Lobe - Centrilobular                  Infiltrat Cell    Mild, Mononuclear Cl
                   - Centrilobular                  Necrosis          Mild
                   - Hepatocyte                     Degen             Minimal
                   - Hepatocyte                     Regeneration      Mild
                   - Sinusoid                       Congestion        Minimal

__________________________________________________________________________________________________________________________________

                                                             Page   92

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 16                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 3
ANIMAL NUM: 435               DOSE: 1500MG/K48 HR                DISP: Terminal Sacrifice                       HISTO: 0203194
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Liver Lft Lobe - Centrilobular                  Infiltrat Cell    Mild, Mononuclear Cl
                   - Centrilobular                  Necrosis          Mild
                   - Hepatocyte                     Regeneration      Mild
                   - Sinusoid                       Congestion        Minimal
                  [ Necrosis           TGLs = 1,2-1 ]

    Liver Med Lobe - Centrilobular                  Infiltrat Cell    Minimal, Mononuclear Cl
                   - Centrilobular                  Necrosis          Mild
                   - Hepatocyte                     Regeneration      Minimal
                   - Sinusoid                       Congestion        Minimal
                  [ Necrosis           TGLs = 1,2-2 ]

__________________________________________________________________________________________________________________________________

                                                             Page   93

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 16                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 3
ANIMAL NUM: 436               DOSE: 1500MG/K48 HR                DISP: Terminal Sacrifice                       HISTO: 0203195
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Liver Lft Lobe - Centrilobular                  Infiltrat Cell    Minimal, Mononuclear Cl
                   - Centrilobular                  Necrosis          Mild

    Liver Med Lobe - Centrilobular                  Infiltrat Cell    Minimal, Mononuclear Cl
                   - Centrilobular                  Necrosis          Mild

__________________________________________________________________________________________________________________________________

                                                             Page   94

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 16                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 3
ANIMAL NUM: 446               DOSE: 1500MG/K48 HR                DISP: Terminal Sacrifice                       HISTO: 0203205
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Liver Lft Lobe - Centrilobular                  Infiltrat Cell    Mild, Mononuclear Cl
                   - Centrilobular                  Necrosis          Mild

    Liver Med Lobe - Centrilobular                  Infiltrat Cell    Minimal, Mononuclear Cl
                   - Centrilobular                  Necrosis          Mild
                   - Sinusoid                       Congestion        Mild

__________________________________________________________________________________________________________________________________

                                                             Page   95

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 16                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 3
ANIMAL NUM: 447               DOSE: 1500MG/K48 HR                DISP: Terminal Sacrifice                       HISTO: 0203206
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Liver Lft Lobe - Centrilobular                  Infiltrat Cell    Moderate, Mononuclear Cl
                   - Centrilobular                  Necrosis          Mild
                   - Hepatocyte                     Regeneration      Minimal

    Liver Med Lobe - Centrilobular                  Infiltrat Cell    Minimal, Mononuclear Cl
                   - Centrilobular                  Necrosis          Mild
                   - Sinusoid                       Congestion        Mild
                  [ Necrosis           TGLs = 1-2 ]

__________________________________________________________________________________________________________________________________

                                                             Page   96

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 16                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 3
ANIMAL NUM: 448               DOSE: 1500MG/K48 HR                DISP: Terminal Sacrifice                       HISTO: 0203207
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Kidney - Renal Tubule                           Necrosis          Minimal

    Liver Lft Lobe - Centrilobular                  Necrosis          Moderate
                   - Hepatocyte                     Degen             Minimal
                   - Hepatocyte                     Regeneration      Moderate
                   - Sinusoid                       Congestion        Moderate
                  [ Necrosis           TGLs = 1-1 ]

    Liver Med Lobe - Centrilobular                  Necrosis          Moderate
                   - Hepatocyte                     Degen             Minimal
                   - Hepatocyte                     Regeneration      Moderate
                   - Sinusoid                       Congestion        Mild
                  [ Necrosis           TGLs = 1-2 ]

__________________________________________________________________________________________________________________________________

                                                             Page   97

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 17                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 1
ANIMAL NUM: 525               DOSE: 2000MG/K6 HR                 DISP: Terminal Sacrifice                       HISTO: 0203208
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   98

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 17                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 1
ANIMAL NUM: 526               DOSE: 2000MG/K6 HR                 DISP: Terminal Sacrifice                       HISTO: 0203209
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Liver Lft Lobe - Centrilobular                  Necrosis          Minimal

    Liver Med Lobe - Centrilobular                  Necrosis          Minimal

__________________________________________________________________________________________________________________________________

                                                             Page   99

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 17                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 1
ANIMAL NUM: 527               DOSE: 2000MG/K6 HR                 DISP: Terminal Sacrifice                       HISTO: 0203210
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Liver Med Lobe - Centrilobular                  Necrosis          Minimal

__________________________________________________________________________________________________________________________________

                                                             Page   100

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 17                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 1
ANIMAL NUM: 537               DOSE: 2000MG/K6 HR                 DISP: Terminal Sacrifice                       HISTO: 0203220
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   101

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 17                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 1
ANIMAL NUM: 538               DOSE: 2000MG/K6 HR                 DISP: Terminal Sacrifice                       HISTO: 0203221
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Med Lobe
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Liver Lft Lobe - Centrilobular                  Infiltrat Cell    Minimal, Mononuclear Cl

__________________________________________________________________________________________________________________________________

                                                             Page   102

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 17                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 1
ANIMAL NUM: 539               DOSE: 2000MG/K6 HR                 DISP: Terminal Sacrifice                       HISTO: 0203222
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Liver Lft Lobe - Centrilobular                  Necrosis          Minimal

    Liver Med Lobe - Centrilobular                  Necrosis          Minimal

__________________________________________________________________________________________________________________________________

                                                             Page   103

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 18                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 528               DOSE: 2000MG/K18 HR                DISP: Terminal Sacrifice                       HISTO: 0203211
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Liver Lft Lobe - Centrilobular                  Necrosis          Mild
                   - Hepatocyte                     Degen             Minimal
                   - Hepatocyte                     Hypertrophy       Minimal
                   - Sinusoid                       Congestion        Mild
                  [ Necrosis           TGLs = 1-1 ]

    Liver Med Lobe - Centrilobular                  Necrosis          Moderate
                   - Hepatocyte                     Degen             Minimal
                   - Sinusoid                       Congestion        Moderate
                  [ Necrosis           TGLs = 1-2 ]

__________________________________________________________________________________________________________________________________

                                                             Page   104

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 18                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 529               DOSE: 2000MG/K18 HR                DISP: Terminal Sacrifice                       HISTO: 0203212
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Liver Lft Lobe - Centrilobular                  Necrosis          Minimal
                   - Hepatocyte                     Degen             Minimal
                   - Sinusoid                       Congestion        Mild
                  [ Necrosis           TGLs = 1-1 ]

    Liver Med Lobe - Centrilobular                  Necrosis          Mild
                   - Hepatocyte                     Degen             Minimal
                   - Sinusoid                       Congestion        Moderate
                  [ Necrosis           TGLs = 1-2 ]

__________________________________________________________________________________________________________________________________

                                                             Page   105

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 18                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 530               DOSE: 2000MG/K18 HR                DISP: Terminal Sacrifice                       HISTO: 0203213
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Liver Lft Lobe - Centrilobular                  Necrosis          Mild
                   - Sinusoid                       Congestion        Mild
                  [ Necrosis           TGLs = 1-1 ]

    Liver Med Lobe - Centrilobular                  Necrosis          Minimal
                   - Sinusoid                       Congestion        Mild
                  [ Necrosis           TGLs = 1-2 ]

__________________________________________________________________________________________________________________________________

                                                             Page   106

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 18                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 540               DOSE: 2000MG/K18 HR                DISP: Terminal Sacrifice                       HISTO: 0203223
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Liver Lft Lobe - Centrilobular                  Necrosis          Mild
                   - Hepatocyte                     Hypertrophy       Minimal
                   - Sinusoid                       Congestion        Moderate
                  [ Necrosis           TGLs = 1-1 ]

    Liver Med Lobe - Centrilobular                  Necrosis          Moderate
                   - Hepatocyte                     Hypertrophy       Minimal
                   - Sinusoid                       Congestion        Moderate
                  [ Necrosis           TGLs = 1-2 ]

__________________________________________________________________________________________________________________________________

                                                             Page   107

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 18                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 541               DOSE: 2000MG/K18 HR                DISP: Terminal Sacrifice                       HISTO: 0203224
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   108

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 18                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 542               DOSE: 2000MG/K18 HR                DISP: Terminal Sacrifice                       HISTO: 0203225
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney                          Liver Lft Lobe                  Liver Med Lobe
__________________________________________________________________________________________________________________________________

                                                             Page   109

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 19                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 531               DOSE: 2000MG/K24 HR                DISP: Terminal Sacrifice                       HISTO: 0203214
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Kidney - Renal Tubule                           Necrosis          Mild

    Liver Lft Lobe - Centrilobular                  Necrosis          Mild
                   - Hepatocyte                     Hypertrophy       Mild
                   - Sinusoid                       Congestion        Mild

    Liver Med Lobe - Centrilobular                  Infiltrat Cell    Minimal, Mononuclear Cl
                   - Centrilobular                  Necrosis          Mild
                   - Hepatocyte                     Hypertrophy       Mild
                   - Sinusoid                       Congestion        Mild

__________________________________________________________________________________________________________________________________

                                                             Page   110

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 19                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 532               DOSE: 2000MG/K24 HR                DISP: Terminal Sacrifice                       HISTO: 0203215
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Kidney - Renal Tubule                           Necrosis          Minimal

    Liver Lft Lobe - Centrilobular                  Necrosis          Mild
                   - Hepatocyte                     Hypertrophy       Minimal
                   - Sinusoid                       Congestion        Minimal

    Liver Med Lobe - Centrilobular                  Necrosis          Moderate
                   - Hepatocyte                     Hypertrophy       Minimal
                   - Sinusoid                       Congestion        Mild

__________________________________________________________________________________________________________________________________

                                                             Page   111

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 19                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 533               DOSE: 2000MG/K24 HR                DISP: Terminal Sacrifice                       HISTO: 0203216
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Liver Lft Lobe - Centrilobular                  Necrosis          Mild
                   - Hepatocyte                     Hypertrophy       Minimal
                   - Sinusoid                       Congestion        Mild

    Liver Med Lobe - Centrilobular                  Necrosis          Moderate
                   - Hepatocyte                     Hypertrophy       Minimal
                   - Sinusoid                       Congestion        Mild

__________________________________________________________________________________________________________________________________

                                                             Page   112

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 19                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 543               DOSE: 2000MG/K24 HR                DISP: Terminal Sacrifice                       HISTO: 0203226
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Kidney - Renal Tubule                           Necrosis          Minimal

    Liver Lft Lobe - Centrilobular                  Necrosis          Mild
                   - Hepatocyte                     Hypertrophy       Mild
                   - Sinusoid                       Congestion        Mild
                  [ Necrosis           TGLs = 1,2-1 ]

    Liver Med Lobe - Centrilobular                  Necrosis          Moderate
                   - Hepatocyte                     Hypertrophy       Mild
                   - Sinusoid                       Congestion        Moderate
                  [ Necrosis           TGLs = 1,2-2 ]

__________________________________________________________________________________________________________________________________

                                                             Page   113

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 19                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 544               DOSE: 2000MG/K24 HR                DISP: Terminal Sacrifice                       HISTO: 0203227
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Kidney - Renal Tubule                           Necrosis          Mild

    Liver Lft Lobe - Centrilobular                  Necrosis          Moderate
                   - Hepatocyte                     Hypertrophy       Mild
                   - Sinusoid                       Congestion        Mild
                  [ Necrosis           TGLs = 1-1 ]

    Liver Med Lobe - Centrilobular                  Necrosis          Moderate
                   - Hepatocyte                     Hypertrophy       Mild
                   - Sinusoid                       Congestion        Mild

__________________________________________________________________________________________________________________________________

                                                             Page   114

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 19                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 2
ANIMAL NUM: 545               DOSE: 2000MG/K24 HR                DISP: Terminal Sacrifice                       HISTO: 0203228
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Liver Med Lobe
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Kidney - Renal Tubule                           Necrosis          Mild

    Liver Lft Lobe - Centrilobular                  Infiltrat Cell    Minimal, Mononuclear Cl
                   - Centrilobular                  Necrosis          Minimal

__________________________________________________________________________________________________________________________________

                                                             Page   115

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 20                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 3
ANIMAL NUM: 534               DOSE: 2000MG/K48 HR                DISP: Terminal Sacrifice                       HISTO: 0203217
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Liver Lft Lobe - Centrilobular                  Infiltrat Cell    Minimal, Mononuclear Cl
                   - Centrilobular                  Necrosis          Mild

    Liver Med Lobe - Centrilobular                  Infiltrat Cell    Minimal, Mononuclear Cl
                   - Centrilobular                  Necrosis          Mild

__________________________________________________________________________________________________________________________________

                                                             Page   116

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 20                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 3
ANIMAL NUM: 535               DOSE: 2000MG/K48 HR                DISP: Terminal Sacrifice                       HISTO: 0203218
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Kidney - Renal Tubule                           Necrosis          Minimal

    Liver Lft Lobe - Centrilobular                  Infiltrat Cell    Mild, Mononuclear Cl
                   - Centrilobular                  Necrosis          Mild
                   - Hepatocyte                     Degen             Mild
                   - Hepatocyte                     Regeneration      Mild
                  [ Necrosis           TGLs = 1,2-1 ]

    Liver Med Lobe - Centrilobular                  Infiltrat Cell    Mild, Mononuclear Cl
                   - Centrilobular                  Necrosis          Mild
                   - Hepatocyte                     Degen             Mild
                   - Hepatocyte                     Regeneration      Mild
                   - Sinusoid                       Congestion        Minimal
                  [ Necrosis           TGLs = 1,2-2 ]

__________________________________________________________________________________________________________________________________

                                                             Page   117

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 20                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 3
ANIMAL NUM: 536               DOSE: 2000MG/K48 HR                DISP: Terminal Sacrifice                       HISTO: 0203219
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Liver Lft Lobe - Centrilobular                  Infiltrat Cell    Minimal, Mononuclear Cl
                   - Centrilobular                  Necrosis          Moderate
                   - Hepatocyte                     Degen             Mild
                   - Sinusoid                       Congestion        Mild
                  [ Necrosis           TGLs = 1-1 ]

    Liver Med Lobe - Centrilobular                  Infiltrat Cell    Minimal, Mononuclear Cl
                   - Centrilobular                  Necrosis          Mild
                   - Hepatocyte                     Degen             Mild

__________________________________________________________________________________________________________________________________

                                                             Page   118

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 20                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 3
ANIMAL NUM: 546               DOSE: 2000MG/K48 HR                DISP: Terminal Sacrifice                       HISTO: 0203229
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Liver Lft Lobe - Centrilobular                  Infiltrat Cell    Minimal, Mononuclear Cl
                   - Centrilobular                  Necrosis          Moderate
                   - Hepatocyte                     Degen             Minimal
                   - Hepatocyte                     Regeneration      Mild
                   - Sinusoid                       Congestion        Moderate
                  [ Necrosis           TGLs = 1-1 ]

    Liver Med Lobe - Centrilobular                  Infiltrat Cell    Minimal, Mononuclear Cl
                   - Centrilobular                  Necrosis          Mild
                   - Hepatocyte                     Degen             Minimal
                   - Hepatocyte                     Regeneration      Mild
                   - Sinusoid                       Congestion        Mild

__________________________________________________________________________________________________________________________________

                                                             Page   119

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 20                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 3
ANIMAL NUM: 547               DOSE: 2000MG/K48 HR                DISP: Terminal Sacrifice                       HISTO: 0203230
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Adren Cortex                    Kidney
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Liver Lft Lobe - Centrilobular                  Infiltrat Cell    Minimal, Mononuclear Cl
                   - Centrilobular                  Necrosis          Mild
                   - Hepatocyte                     Regeneration      Minimal
                   - Sinusoid                       Congestion        Mild

    Liver Med Lobe - Centrilobular                  Infiltrat Cell    Minimal, Mononuclear Cl
                   - Centrilobular                  Necrosis          Moderate
                   - Hepatocyte                     Regeneration      Minimal
                   - Sinusoid                       Congestion        Mild

__________________________________________________________________________________________________________________________________

                                                             Page   120

NTP Experiment-Test: 55801-07                       INDIVIDUAL ANIMAL PATHOLOGY DATA                              Report: PEIRPT14
Study Type: ACUTE                                  ACETAMINOPHEN (4-HYDROXYACETANILIDE)                           Date: 08/24/04
Route: GAVAGE                                                                                                     Time: 14:06:52

__________________________________________________________________________________________________________________________________

                               TMT: 20                    SEX/SPECIES: Male    FISCHER 344 RATS           DAY ON DOSE: 3
ANIMAL NUM: 548               DOSE: 2000MG/K48 HR                DISP: Terminal Sacrifice                       HISTO: 0203231
__________________________________________________________________________________________________________________________________

                                                ORGAN AND ACCOUNTABLE SITE STATUS
__________________________________________________________________________________________________________________________________

NORMAL
    Kidney
__________________________________________________________________________________________________________________________________

OBSERVATIONS

    Liver Lft Lobe - Centrilobular                  Infiltrat Cell    Mild, Mononuclear Cl
                   - Centrilobular                  Necrosis          Mild
                   - Sinusoid                       Congestion        Mild

    Liver Med Lobe - Centrilobular                  Infiltrat Cell    Mild, Mononuclear Cl
                   - Centrilobular                  Necrosis          Moderate
                   - Hepatocyte                     Regeneration      Minimal
                   - Sinusoid                       Congestion        Mild

__________________________________________________________________________________________________________________________________

                                                             Page   121

                                               -----------------------------------
                                               ---------- END-OF-REPORT ----------
                                               -----------------------------------