From ntpmail at list.niehs.nih.gov  Fri Jan 12 09:49:24 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Fri Jan 12 09:49:33 2007
Subject: NTP UPDATE: NTP News Update - January 2007
Message-ID: <C1CD0A24.CD0B%soward@niehs.nih.gov>

The NTP News Update for January 2007 is now available at URL:
http://ntp.niehs.nih.gov/ntpweb/index.cfm?objectid=16BD253C-F1F6-975E-767833
FEAE4D176A
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From ntpmail at list.niehs.nih.gov  Wed Jan 17 12:41:22 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Wed Jan 17 12:41:31 2007
Subject: NTP UPDATE: NTP TR-535 now available
Message-ID: <C1D3C9F2.CE81%soward@niehs.nih.gov>

The final TR-535, NTP Toxicology and Carcinogenesis Studies of
4-Methylimidazole  (CAS No. 822-36-6) in F344/N Rats and B6C3F1 Mice (Feed
Studies) is now available.

See URL: http://ntp.niehs.nih.gov/go/tr

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From ntpmail at list.niehs.nih.gov  Mon Jan 22 08:54:47 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Mon Jan 22 08:55:25 2007
Subject: NTP UPDATE: 2007 Conference of the International Society of
	Exposure Analysis
Message-ID: <C1DA2C58.CFC5%soward@niehs.nih.gov>

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From ntpmail at list.niehs.nih.gov  Mon Jan 22 09:26:48 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Mon Jan 22 09:26:58 2007
Subject: NTP UPDATE: Updated Status Information
Message-ID: <C1DA33D8.CFD7%soward@niehs.nih.gov>

NTP results & status information for all NTP studies has been updated; you
may search testing status of agents using the following url:
    http://ntp.niehs.nih.gov:8080/index.html?col=010stat
> 
The updated NTP Management Status report for carcinogenicity/toxicity
studies is available at the following url:
    http://ntp.niehs.nih.gov/go/msr

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From ntpmail at list.niehs.nih.gov  Wed Feb 21 09:35:52 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Wed Feb 21 09:36:00 2007
Subject: NTP UPDATE: Updated NTP Testing Status
Message-ID: <C201C2F8.DBCA%soward@niehs.nih.gov>

NTP results & status information for all NTP studies has been updated; you
may search testing status of agents using the following url:
    http://ntp.niehs.nih.gov:8080/index.html?col=010stat
> 
The updated NTP Management Status report for carcinogenicity/toxicity
studies is available at the following url:
    http://ntp.niehs.nih.gov/go/msr

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From ntpmail at list.niehs.nih.gov  Fri Feb 23 16:00:22 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Fri Feb 23 16:00:36 2007
Subject: NTP UPDATE: NTP TOX-72 now available
Message-ID: <C204C016.DD46%soward@niehs.nih.gov>

The final TOX-72, NTP Toxicity Report on Toxicity Studies of Sodium
Dichromate Dihydrate (CAS 7789-12-0) Administered in Drinking Water to Male
and Female F344/N Rats and B6C3F1 Mice and Male BALB/c and am3-C57BL/6 Mice
is now available.  

See URL: http://ntp.niehs.nih.gov/go/14372

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From ntpmail at list.niehs.nih.gov  Mon Feb 26 14:59:17 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Mon Feb 26 14:59:49 2007
Subject: NTP UPDATE: CERHR announces availability of Hydroxyurea report and
 reminder of independent panel evaluation of Bisphenol A
Message-ID: <C208A645.DDFF%soward@niehs.nih.gov>

* NTP Center for the Evaluation of Risks to Human Reproduction (CERHR)
announces the availability of the Hydroxyurea expert panel report and
request public comment.  See FR Notice:
http://ntp.niehs.nih.gov/index.cfm?objectid=FF7E8CEF-F1F6-975E-7CD3A67D030E8
823
> 
* CERHR also announces the Independent Panel to evaluate Bisphenol A to be
held March 5-7, 2007.  See News Advisory:
http://ntp.niehs.nih.gov/ntpweb/index.cfm?objectid=FF887B0F-F1F6-975E-7A29D1
C9CDA56F50

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From ntpmail at list.niehs.nih.gov  Fri Mar  2 12:03:31 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Fri Mar  2 12:03:22 2007
Subject: NTP UPDATE: NTP{ announces 
Message-ID: <C20DC313.2313%soward@niehs.nih.gov>

The National Toxicology Program announces the May 16-17, 2007 meeting of the
Board of Scientific Counselors Technical Reports Review Subcommittee and
requests comments.

The meeting page can be found at URL:
http://ntp.niehs.nih.gov/go/15833

Federal Register Notice:
http://ntp.niehs.nih.gov/ntpweb/index.cfm?objectid=13815C89-F1F6-975E-753BEE
786032690F

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From ntpmail at list.niehs.nih.gov  Thu Mar  8 10:55:22 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Thu Mar  8 10:55:52 2007
Subject: NTP UPDATE: Availability of Pathology Data Tables for NTP Studies
Message-ID: <C2159C1A.E370%soward@niehs.nih.gov>

Pathology data tables for reports P03, P09, P10, P18 for the Sodium
Dichromate Dihydrate study have been revised and may be viewed at URL:
http://ntp.niehs.nih.gov/go/29141

The NTP Pathology Working Group has reviewed the following studies and final
pathology tables have been generated.  The complete set of data tables for
these studies (body weight, clinical observations, survival, and pathology)
are available on the NTP website at URL:
http://ntp.niehs.nih.gov/go/peerreview

> TR-541 Formamide
> TR-542 Cumene
> TR-544 Dibromoacetonitrile
> TR-546 Sodium Dichromate Dihydrate
> TR-549 Bromochloroacetic Acid
> TR-550 Cresols
> TR-551 Isoeugenol
> TR-552 Propargyl Alcohol
> TR-554 5-(Hydroxymethyl)-2-furfural
> TR-555 1,2-Dibromo-2,4-dicyanobutane
> TR-(tbd) Chromium Picolinate Monohydrate
> TOX-60 Peroxisome Project (Dibutylphthalate)
> TOX-62 Peroxisome Project (WY-14,643)
> TOX-63 Peroxisome Project (2,4-Dichlorophenoxyacetic acid)
> TOX-64 Peroxisome Project (Gemfibrozil)
> TOX-75 Dimethylaminopropyl Chloride Hydrochloride
> TOX-76 2,4-Hexadienal
> TOX-77 Hexachlorobenzene
> TOX-81 alpha-Pinene

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From ntpmail at list.niehs.nih.gov  Fri Mar 16 10:35:47 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Fri Mar 16 10:35:58 2007
Subject: NTP UPDATE: Updated NTP Testing Status
Message-ID: <C2202383.E6BE%soward@niehs.nih.gov>

NTP results & status information for all NTP studies has been updated; you
may search testing status of agents using the following url:
    http://ntp.niehs.nih.gov:8080/index.html?col=010stat
> 
The updated NTP Management Status report for carcinogenicity/toxicity
studies is available at the following url:
    http://ntp.niehs.nih.gov/go/msr

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From ntpmail at list.niehs.nih.gov  Wed Mar 21 11:59:20 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Wed Mar 21 11:59:55 2007
Subject: NTP UPDATE: NTP at the Society of Toxicology 46th Annual Meeting
	and ToxExpo
Message-ID: <C226CE99.E904%soward@niehs.nih.gov>

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From ntpmail at list.niehs.nih.gov  Sun Apr  1 17:53:43 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Sun Apr  1 17:54:16 2007
Subject: NTP UPDATE: Toxicological Study Nominations Announced;
	Comments Requested
Message-ID: <C235A227.29CD%soward@niehs.nih.gov>

The NTP office of Chemical Nomination and Selection announcement of and
request for public comment on Toxicological Study Nominations to the NTP.

Federal Register Announcement:
http://ntp.niehs.nih.gov/index.cfm?objectid=AF0BAC2C-F1F6-975E-75C014AE91EBC
6C2

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From ntpmail at list.niehs.nih.gov  Mon Apr  2 13:11:13 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Mon Apr  2 13:11:27 2007
Subject: NTP UPDATE: NTP News Update - April 2007
Message-ID: <C236B171.ED36%soward@niehs.nih.gov>

The NTP News Update for April 2007 is now available at URL:
http://ntp.niehs.nih.gov/go/29068

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From ntpmail at list.niehs.nih.gov  Mon Apr  2 14:33:33 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Mon Apr  2 14:34:30 2007
Subject: NTP UPDATE: CERHR announces 2nd Bisphenol A meeting & interim report
Message-ID: <C236C4BD.ED5C%soward@niehs.nih.gov>

The Center for the Evaluation of Risks to Human Reproduction (CERHR)
announces the Second Bisphenol A Expert Panel Meeting, availability of
Interim Draft Report, and requests public comment.

You may view the Federal Register Notice at the URL:
http://ntp.niehs.nih.gov/index.cfm?objectid=B3787081-F1F6-975E-7A4B46066CDCE
421

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From ntpmail at list.niehs.nih.gov  Wed Apr  4 16:33:53 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Wed Apr  4 16:34:02 2007
Subject: NTP UPDATE: Technical Reports TR-523 & TR-538 now available
Message-ID: <C23983F1.EF21%soward@niehs.nih.gov>

Final National Toxicology Program technical reports are now available for
the following studies:

TR-523:   Toxicology and Carcinogenesis Studies of Diisopropylcarbodiimide
(CAS No. 693-13-0) in F344/N Rats and B6C3F1  Mice (Dermal Studies)

TR-538:  Toxicology and Carcinogenesis Studies of Methyl Isobutyl Ketone
(CAS No. 108-10-1) in F344/N Rats and B6C3F1  Mice (Inhalation Studies)

See URL: http://ntp.niehs.nih.gov/go/tr

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From ntpmail at list.niehs.nih.gov  Tue Apr 10 13:11:50 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Tue Apr 10 13:12:20 2007
Subject: NTP UPDATE: Updated Meeting Agenda - May Subcommittee
Message-ID: <C2413D96.F1D3%soward@niehs.nih.gov>

An updated agenda has been posted for the NTP Technical Reports Review
Subcommittee meeting to be held May 16-17, 2007.  Isoeugenol (TR-551) will
not be reviewed at this meeting. The agenda and additional information about
this meeting may be found at:
http://ntp.niehs.nih.gov/go/15833

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From ntpmail at list.niehs.nih.gov  Thu Apr 12 14:51:49 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Thu Apr 12 14:52:20 2007
Subject: NTP UPDATE: Availability of Draft Technical Reports
Message-ID: <C243F805.F35B%soward@niehs.nih.gov>

The NTP announces the availability of the Draft Technical Reports on
cresols, cumene, ethinyl estradiol (multigeneration and carcinogenicity),
formamide, propargyl alcohol, and sodium dichromate dihydrate that will be
reviewed at the NTP Technical Reports Review Subcommittee Meeting on May
16-17, 2007 in Research Triangle Park.   The reports can be obtained from
the NTP website at http://ntp.niehs.nih.gov/go/28960.  Additional
information about the meeting is available at
http://ntp.niehs.nih.gov/go/15833.

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From ntpmail at list.niehs.nih.gov  Mon Apr 16 15:00:39 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Mon Apr 16 15:01:09 2007
Subject: NTP UPDATE: RoC announces review process for 12th Edition
Message-ID: <C2494017.F5D2%soward@niehs.nih.gov>

Today, NTP released of the final review process for preparation of the 12th
Report on Carcinogens and announced its availability in the Federal
Register.  The review process is available at
http://ntp.niehs.nih.gov/go/15208

 
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From ntpmail at list.niehs.nih.gov  Mon Apr 16 16:02:56 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Mon Apr 16 16:03:05 2007
Subject: NTP UPDATE: Updated NTP Testing Status
Message-ID: <C2494EB0.F5F7%soward@niehs.nih.gov>

NTP results & status information for all NTP studies has been updated; you
may search testing status of agents using the following url:
    http://ntp.niehs.nih.gov:8080/index.html?col=010stat
> 
The updated NTP Management Status report for carcinogenicity/toxicity
studies is available at the following url:
    http://ntp.niehs.nih.gov/go/msr

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From ntpmail at list.niehs.nih.gov  Fri Apr 20 13:38:19 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Fri Apr 20 13:38:50 2007
Subject: NTP UPDATE: Final NTP Genetically Modified Model Reports now
	available
Message-ID: <C24E72CB.F8A1%soward@niehs.nih.gov>

Final National Toxicology Program Genetically Modified Model Reports are now
available for the following studies:

GMM-06:  Toxicology Studies of Sodium Bromate (CAS No. 7789-38-0) in
Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal and Drinking Water
Studies) and Carcinogenicity Studies of Sodium Bromate in Genetically
Modified [B6.129-Trp53[tm1Brd] (N5) Haploinsufficient] Mice (Drinking Water
Studies)

GMM-10:  Toxicology Study of Diispropylcarbodiimide (CAS No. 693-13-0) in
Genetically Modified (FVB Tg.AC Hemizygous) Mice and Carcinogenicity Study
of Diispropylcarbodiimide in Genetically Modified [B6.129-Trp53[tm1Brd]
(N5) Haploinsufficient Mice (Dermal Studies)

See URL:  http://ntp.niehs.nih.gov/go/14367

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From ntpmail at list.niehs.nih.gov  Tue May  1 14:32:37 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Tue May  1 14:32:48 2007
Subject: NTP UPDATE: Technical Report on Dibromoacetic Acid now available
Message-ID: <C25D0005.FCB0%soward@niehs.nih.gov>

The final TR-537, National Toxicology Program Toxicology and Carcinogenesis
Studies of Dibromoacetic Acid (CAS No. 631-64-1) in F344/N Rats and B6C3F1
Mice (Drinking Water Studies) is now available.

See URL:  http://ntp.niehs.nih.gov/go/tr

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From ntpmail at list.niehs.nih.gov  Wed May  2 14:53:16 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Wed May  2 14:53:21 2007
Subject: NTP UPDATE: CERHR postpones meeting
Message-ID: <C25E565C.FD89%soward@niehs.nih.gov>

The NTP Center for the Evaluation of Risks to Human Reproduction (CERHR)
announces the postponement of the Second Bisphenol A Expert Panel Meeting
and extension of public comment period for the Interim Draft Expert Panel
Report on Bisphenol A

See Announcement:
http://ntp.niehs.nih.gov/ntpweb/index.cfm?objectid=4DFAEDAB-F1F6-975E-7AC0B7
6516EB1201

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From ntpmail at list.niehs.nih.gov  Wed May  2 15:00:15 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Wed May  2 15:00:19 2007
Subject: NTP UPDATE: SACATM Meeting & Request for Comment
Message-ID: <C25E57FF.FD8C%soward@niehs.nih.gov>

The NTP Liaison and Scientific Review Office announces a meeting of the
Scientific Advisory Committee on Alternative Toxicological Methods (SACATM)
and requests comments.  The announcement and additional information may be
found on the meeting page: http://ntp.niehs.nih.gov/go/7441

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From ntpmail at list.niehs.nih.gov  Wed May  2 15:04:59 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Wed May  2 15:05:04 2007
Subject: NTP UPDATE: NICEATM announces availability of Draft 5-Year Plan
Message-ID: <C25E591B.FD90%soward@niehs.nih.gov>

The NTP Interagency Center for the Evaluation of Alternative Toxicological
Methods (NICEATM) announces the availability of the Draft NICEATM-ICCVAM
5-Year Plan and Request for Public Comments; Announcement of a Town Meeting
on the Draft NICEATM-ICCVAM 5-Year Plan.  See Announcement:
http://ntp.niehs.nih.gov/ntpweb/index.cfm?objectid=4E09B4C1-F1F6-975E-7D92C4
1D23B6E8CF

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From ntpmail at list.niehs.nih.gov  Thu May 10 10:43:20 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Thu May 10 10:47:01 2007
Subject: NTP UPDATE: Federal Register Announcements
Message-ID: <C268A7C8.8DEB%nichols3@niehs.nih.gov>

The National Toxicology Program invites nominations of scientific experts to
serve on expert panels for 12th Report on Carcinogens.  See FR Notice:
http://ntp.niehs.nih.gov/files/roc_72_fr_89.pdf

 
The National Toxicology Program Interagency Center for the Evaluation of
Alternative Toxicological Methods (NICEATM) announces availability of the
Peer Review Panel Report on Five In Vitro Pyrogen Test Methods and requests
public comments.  See FR Notice:
http://iccvam.niehs.nih.gov/SuppDocs/FedDocs/FR/FR_E7_8896.pdf

 
NICEATM announces request for data on the use of topical anesthetics and
systemic analgesics for in vivo eye irritation testing.  See FR Notice:
http://iccvam.niehs.nih.gov/SuppDocs/FedDocs/FR/FR_E7_8898.pdf
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From ntpmail at list.niehs.nih.gov  Tue May 15 14:41:01 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Tue May 15 14:41:31 2007
Subject: NTP UPDATE: June 22 NTP Board Meeting is announced
Message-ID: <C26F76FD.1027F%soward@niehs.nih.gov>

The National Toxicology Program (NTP) Liaison and Scientific Review Office
announces a meeting of the NTP Board of Scientific Counselors to be held on
June 22, 2007.  The Federal Register Notice and additional meeting
information can be found at the following URL:
http://ntp.niehs.nih.gov/go/165

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From ntpmail at list.niehs.nih.gov  Thu May 17 14:23:14 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Thu May 17 14:23:44 2007
Subject: NTP UPDATE: NICEATM Murine Local Lymph Node Assay announcement
Message-ID: <C27215D2.10403%soward@niehs.nih.gov>

National Toxicology Program (NTP) Interagency Center for the Evaluation of
Alternative Toxicological Methods (NICEATM); the Murine Local Lymph Node
Assay:  Request for Comments, Nominations of Scientific Experts, and
Submission of Data. See Federal Register Notice:
http://ntp.niehs.nih.gov/files/72FR95_27815.pdf

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From ntpmail at list.niehs.nih.gov  Tue May 22 09:17:01 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Tue May 22 09:17:35 2007
Subject: NTP UPDATE: Attend the June 11th Town Meeting on Draft
 NICETAM-ICCVAM Five Year-Plan
In-Reply-To: <C2786427.105D2%soward@niehs.nih.gov>
Message-ID: <C278658D.105D6%soward@niehs.nih.gov>

Your comments and participation are encouraged as federal agencies look for
new ways to reduce, refine and replace the use of animals in testing.  The
National Toxicology Program (NTP) Interagency Center for the Evaluation of
Alternative Toxicological Methods (NICEATM) and the Interagency Coordinating
Committee on The Validation of Alternative Methods (ICCVAM) invite you to
attend a Town Meeting on June 11th from 1:00 to 5:00 PM at the William H.
Natcher Conference Center, Room E, at NIH in Bethesda, MD to hear about
their draft five-year plan and to provide members of the public
opportunities for input.
 
The ?Draft NICETAM-ICCVAM Five Year-Plan? available at
http://iccvam.niehs.nih.gov/docs/5yearplan.htm addresses four key
challenges: 
* Identify priority areas and methods to reduce and replace animal use and
reduce animal pain and distress
* Incorporate advances in science and technologies to develop new test
methods and approaches
* Proactively communicate the use of alternative test methods to government
and non-government stakeholders
* Develop and strengthen partnerships to promote research, development,
translation, and validation activities for alternative test methods
 
Attend the Monday, June 11th Town Meeting:
Please complete the online registration by June 7th at the NICEATM?ICCVAM
website 
http://iccvam.niehs.nih.gov/meetings/5YPlanTM/townmtg.htm; OR
Phone NICEATM at 919-541-2384
Email at niceatm@niehs.nih.gov.
 
Provide Written Comments:
Please submit written comments electronically at
http://iccvam.niehs.nih.gov/contact/FR_pubcomment.htm
Comments can also be submitted by e-mail to 5yearplan@niehs.nih.gov
Please include appropriate contact information (name, affiliation, mailing
address, phone, fax, e-mail, and sponsoring organization, if applicable).
 
Reasonable Accommodation Needs:
Persons needing special assistance, such as sign language interpretation or
other reasonable accommodation in order to attend, should contact
919?541?2475 voice, 919?541?4644 TTY (text telephone), through the Federal
TTY Relay System at 800?877?8339, or send e-mail to niehsoeeo@niehs.nih.gov.
Requests should be made at least 7 days in advance of the meeting.
 
ICCVAM, a permanent interagency committee administered by the  National
Institute of Environmental Health Sciences under NICEATM, is composed of
members designated by the heads of 15 federal agencies. ICCVAM was created
under the ICCVAM Authorization Act of 2000 (42 U.S.C 285l-3).

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From ntpmail at list.niehs.nih.gov  Tue Jun  5 12:35:44 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Tue Jun  5 12:35:53 2007
Subject: NTP UPDATE: Final NTP Genetically Modified Model Reports now
	available
Message-ID: <C28B0920.10AFC%soward@niehs.nih.gov>

Final National Toxicology Program Genetically Modified Model Reports are now
available for the following studies:

GMM-05:  Toxicology Studies of Bromodichloromethane (CAS No. 75-27-4) in
Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal, Drinking Water,
and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in
Genetically Modified [B6.129-Trp53tm1Brd  (N5) Haploinsufficient] Mice
(Drinking Water and Gavage Studies)

GMM-11:  Toxicology Studies of Dichloroacetic Acid (CAS No. 79-43-6) in
Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal and Drinking Water
Studies) and Carcinogenicity Studies of Dichloroacetic Acid in Genetically
Modified [B6.129-Trp53tm1Brd  (N5) Haploinsufficient Mice (Drinking Water
Studies)

See URL:  http://ntp.niehs.nih.gov/go/14367

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From ntpmail at list.niehs.nih.gov  Mon Jun 11 09:02:32 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Mon Jun 11 09:03:02 2007
Subject: NTP UPDATE: Videocast Information for June 11th Town Meeting on
 Draft NICETAM-ICCVAM Five Year-Plan
Message-ID: <C292C028.10D8E%soward@niehs.nih.gov>

The National Toxicology Program (NTP) Interagency Center for the Evaluation
of Alternative Toxicological Methods (NICEATM) and the Interagency
Coordinating Committee on The Validation of Alternative Methods (ICCVAM)
will hold a Town Meeting today, Monday, June 11, from 1:00 to 5:00 PM at the
William H. Natcher Conference Center, Room E, at NIH in Bethesda, MD to
provide members of the public opportunities for input on their draft
five-year plan.  
 
The ?Draft NICETAM-ICCVAM Five Year-Plan? available at
http://iccvam.niehs.nih.gov/docs/5yearplan.htm addresses four key
challenges: 
* Identify priority areas and methods to reduce and replace animal use and
reduce animal pain and distress
* Incorporate advances in science and technologies to develop new test
methods and approaches
* Proactively communicate the use of alternative test methods to government
and non-government stakeholders
* Develop and strengthen partnerships to promote research, development,
translation, and validation activities for alternative test methods

The videocast of this meeting <http://videocast.nih.gov/>  will be available
under ?Today?s Events? 

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From ntpmail at list.niehs.nih.gov  Tue Jun 12 12:06:35 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Tue Jun 12 12:07:09 2007
Subject: NTP UPDATE: NICEATM request for submission of relevant data
Message-ID: <C2943CCB.10E38%soward@niehs.nih.gov>

The National Toxicology Program (NTP) Interagency Center for the Evaluation
of Alternative Toxicological Methods (NICEATM) requests ocular irritancy
test data from human, rabbit, and in vitro studies using standardized
testing methods.  See Federal Register notice at URL:

http://ntp.niehs.nih.gov/index.cfm?objectid=209E178E-F1F6-975E-7C10EE2744768
79B

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From ntpmail at list.niehs.nih.gov  Wed Jun 13 10:23:30 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Wed Jun 13 10:24:02 2007
Subject: NTP UPDATE: Editor-in-chief, EHP
In-Reply-To: <8BB67CD070A6EE479378FBE1CEB7947802052F8D@NIHCESMLBX6.nih.gov>
Message-ID: <C2957622.10E9D%soward@niehs.nih.gov>

A vacancy for the position of Editor-in-Chief for Environmental Health
Perspectives located at the National Institute of Environmental Health
Sciences (NIEHS) is currently being advertised and is open to all qualified
individuals.  Please see the job posting at the link below:

 
http://jobsearch.usajobs.opm.gov/getjob.asp?JobID=58175449=2007%2D05%2D30+07
%3A45%3A59=0=18015=Y=rv=d=3876=0=Y.x=61.y=8
<http://jobsearch.usajobs.opm.gov/getjob.asp?JobID=58175449&AVSDM=2007%2D05%
2D30+07%3A45%3A59&Logo=0&lid=18015&FedEmp=Y&sort=rv&vw=d&brd=3876&ss=0&FedPu
b=Y&SUBMIT1.x=61&SUBMIT1.y=8>

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From ntpmail at list.niehs.nih.gov  Fri Jun 15 11:39:51 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Fri Jun 15 11:40:21 2007
Subject: NTP UPDATE: New NTP Associate Director Named
In-Reply-To: <C2982A94.11016%soward@niehs.nih.gov>
Message-ID: <C2982B07.1101B%soward@niehs.nih.gov>

Today the National Toxicology Program announces the appointment of Dr. John
Bucher as the new associate director.

See Press Release: 
http://ntp.niehs.nih.gov/files/NTPAssociate_Directorfinal.pdf

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From ntpmail at list.niehs.nih.gov  Fri Jun 15 15:24:11 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Fri Jun 15 15:25:55 2007
Subject: NTP UPDATE: CERHR announces 2nd BPA Expert Panel Meeting
Message-ID: <C2985F9B.11048%soward@niehs.nih.gov>

The NTP Center for the Evaluation of Risks to Human Reproduction (CERHR)
announces the second Bisphenol A Expert Panel meeting August 6-8, 2007 and
requests comments.

More information available on the meeting page web link:
http://cerhr.niehs.nih.gov/chemicals/bisphenol/bisphenol-mtg.html

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From ntpmail at list.niehs.nih.gov  Tue Jun 19 12:12:22 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Tue Jun 19 12:12:55 2007
Subject: NTP UPDATE: Biomarkers applications and technologies workshop is
	announced
In-Reply-To: <C29D74EB.1AC65%wolfe@niehs.nih.gov>
Message-ID: <C29D78A7.111BA%soward@niehs.nih.gov>

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From ntpmail at list.niehs.nih.gov  Fri Jul 13 08:25:07 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Fri Jul 13 08:25:37 2007
Subject: NTP UPDATE: EHP
Message-ID: <C2BCE763.11B13%soward@niehs.nih.gov>

 
July 12, 2007 
 
Dear Colleague, 
 
We want to take this opportunity to provide you some updated information
regarding our scientific journal, Environmental Health Perspectives (EHP),
and to thank you for your expressed confidence in this publication. We are
glad to know that you highly value EHP as a scientific resource, and as an
effective educational and news resource on environmental health topics.
 
We assure you that the entire leadership team at the National Institute of
Environmental Health Sciences (NIEHS) is fully committed to publishing EHP
and to providing the support necessary to sustain EHP as a leading journal.
We are pleased to let you know that the EHP impact factor continues to rise,
increasing from 3.929 in 2004 to 5.861 in 2007. According to Journal
Citation Reports Science Edition, EHP ranks first among 144 Environmental
Sciences journals and third among 98 Public, Environmental and Occupational
Health journals. 
 
The NIEHS is actively recruiting candidates to serve as the journal?s new
Editor-in-Chief. This position will be a full-time federal appointment, as
it has been in the past.
 
Additionally, technological support for the journal has been upgraded. A
web-based manuscript management system now being implemented will greatly
enhance the scientific peer-review and publication processes.
 
EHP has always been produced with the assistance of a publishing services
contractor. The current contract will expire this year, and the National
Library of Medicine has issued a new contract solicitation on behalf of the
NIEHS. The solicitation can be found on the Federal Business Opportunities
website, www.fbo.gov <http://www.fbo.gov/> .
 
As specified in the contract solicitation, EHP will remain an ?open-access?
publication, available free of charge on-line at www.ehponline.org . EHP
will also continue to be produced as a printed journal available through
subscription. 
Since 1972, the NIEHS has published EHP to provide a worldwide forum for
research and education on environmental health sciences. The NIEHS is proud
to continue its full support for the future success of EHP.
 
Sincerely, 
 
William Martin, M.D.
Associate Director 
National Institute of Environmental Health Sciences
National Institutes of Health
 
Samuel Wilson, M.D.
Deputy Director 
National Institute of Environmental Health Sciences
National Institutes of Health
 
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From ntpmail at list.niehs.nih.gov  Mon Jul 16 10:29:07 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Mon Jul 16 10:29:36 2007
Subject: NTP UPDATE: NTP News Update - July 2007
Message-ID: <C2C0F8F3.11BC5%soward@niehs.nih.gov>

The NTP News Update for July 2007 is now available at URL:
http://ntp.niehs.nih.gov/go/29068

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From ntpmail at list.niehs.nih.gov  Thu Jul 19 14:53:47 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Thu Jul 19 14:54:03 2007
Subject: NTP UPDATE: Correction to NTP News Update for July
Message-ID: <C2C52B7B.11DBA%soward@niehs.nih.gov>

The NTP News Update for July 2007 sent on July 16, listed the date for the
Second Meeting of the CERHR Expert Panel on Bisphenol A (pages 2 & 4) as
August 6-8, 2008 ? the meeting will be held August 6-8, 2007.

The corrected News Update can be found at URL:
http://ntp.niehs.nih.gov/go/29068

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From ntpmail at list.niehs.nih.gov  Fri Jul 27 15:29:46 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Fri Jul 27 15:30:16 2007
Subject: NTP UPDATE: Update on NTP Activities
Message-ID: <C2CFBFEA.120B7%soward@niehs.nih.gov>

Update on NTP Activities
Over the past few months, the National Toxicology Program (NTP) has
undertaken a number of activities to address issues related to conflicts of
interest (COI) and to ensure continued public confidence in its work. These
included an independent review of its contracts for potential COI,
development of a strong clause about COI for adding to NTP contracts, and an
audit to assess the objectivity of information in draft reports prepared on
the reproductive and developmental toxicity of bisphenol A (BPA). NTP would
like to update you on these activities.
 
Review of NTP contracts
A working group of the NTP Board of Scientific Counselors conducted a review
of NTP contracts to (1) assess potential COI, (2) develop recommendations
appropriate for reducing the potential for conflicts to occur, and (3)
address mechanisms for mitigating any current or future COI. The working
group reviewed NTP contracts, information on contract performance provided
by NTP staff, and information on policies and practices concerning COI
provided by selected NTP contractors. The working group report was presented
to the NTP Board of Scientific Counselors at its meeting on June 22, 2007,
and following discussion, accepted unanimously without revision. The working
group found no evidence of actual or apparent COI in its review of NTP
contracts; however, it did recommend a number of best practices and areas
where improvements could be made. The working group report is posted on the
NTP web site
(http://ntp.niehs.nih.gov under ?Latest News?).
 
COI clause for NTP contracts
A clause that specifically addresses contractor COI was developed and is
being added to all NTP contracts. This action complements the review of NTP
contracts by the NTP Board of Scientific Counselors Working Group, as noted
above (see BSC Working Group report, Attachment 9, available
at http://ntp.niehs.nih.gov under ?Latest News?).
 
Audit of draft BPA reports
The NTP Center for the Evaluation of Risks to Human Reproduction (CERHR)
conducts rigorous independent scientific evaluations to assess risk to human
reproduction and development caused by environmental agents, such as
bisphenol A, a chemical currently under review. In response to concerns
raised about Sciences International, Inc. (SI), the former CERHR contractor
(see March 2007 and April 2007 statements available at
http://cerhr.niehs.nih.gov under ?CERHR News?), NTP committed to a review of
the contractor?s services to CERHR.  As part of this review, NTP conducted
an audit of two key activities carried out by SI: (1) selection of
literature relevant for review by the expert panel on BPA and (2)
incorporation of input from expert panel members into draft reports.
 
NTP found that SI made available to the expert panel members for their
consideration appropriate references relevant to the BPA evaluation. NTP
also found that SI reliably made changes to the draft reports requested by
the expert panel. Based upon this audit, NTP concluded that the draft expert
panel reports are useful for the BPA evaluation.  The audit report is posted
on the NTP 
(http://ntp.niehs.nih.gov under ?Latest News?) and CERHR
(http://cerhr.niehs.nih.gov under ?CERHR News?) web sites.
 
Second BPA Expert Panel Meeting
The second BPA expert panel meeting is scheduled for August 6-8, 2007, at
the Hilton Alexandria Old Town in Alexandria, Virginia.  Details about the
meeting are available on the CERHR web site for BPA (
http://cerhr.niehs.nih.gov/chemicals/bisphenol/bisphenol-mtg.html ).
 
 

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From ntpmail at list.niehs.nih.gov  Wed Aug  1 15:28:48 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Wed Aug  1 15:29:14 2007
Subject: NTP UPDATE: RoC announces expert panel meeting on draft background
	documents
Message-ID: <C2D65730.12291%soward@niehs.nih.gov>

The NTP Report on Carcinogens (RoC) announces the availability of draft
background documents on captafol and ortho-nitrotoluene, requests public
comment on these draft documents, and announces the captafol and
ortho-nitrotoluene expert panel meeting.  See the Federal Register notice,
draft background documents and  meeting information available on the NTP
website:
http://ntp.niehs.nih.gov/go/29679

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From ntpmail at list.niehs.nih.gov  Fri Aug 10 09:17:54 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Fri Aug 10 09:18:03 2007
Subject: NTP UPDATE: Availability of Pathology Data Tables for NTP Studies
Message-ID: <C2E1DDC2.126F9%soward@niehs.nih.gov>

The NTP Pathology Working Group has reviewed the following study and final
pathology tables have been generated for beta-Myrcene (mice) and are
available at the NTP website URL:
http://ntp.niehs.nih.gov/go/29763

The complete set of data tables (body weight, clinical observations,
survival, and pathology) for studies planned for peer review are available
on the NTP website at URL:
http://ntp.niehs.nih.gov/go/peerreview

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From ntpmail at list.niehs.nih.gov  Fri Aug 10 11:53:59 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Fri Aug 10 11:54:29 2007
Subject: NTP UPDATE: CERHR expert panel on bisphenol A
Message-ID: <C2E20257.1271E%soward@niehs.nih.gov>

The NTP Center for the Evaluation of Risks to Human Reproduction (CERHR)
held the second public meeting of the expert panel on bisphenol A on August
6-8, 2007, in Alexandria, VA.  The panel continued its review and assessment
of the scientific literature on the potential reproductive and developmental
hazards of bisphenol A.  The meeting summary, which includes the panel?s
conclusions regarding bisphenol A, is available on the NTP website at
http://ntp.niehs.nih.gov (see ?Latest News?).   The expert panel report will
now be prepared for publication and made available to the public for
comment.  NTP will announce availability of the report through the Federal
Register and the NTP email listserv.

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From ntpmail at list.niehs.nih.gov  Mon Aug 13 09:20:45 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Mon Aug 13 09:20:54 2007
Subject: NTP UPDATE: Updated NTP Testing Status
Message-ID: <C2E5D2ED.1279C%soward@niehs.nih.gov>

NTP results & status information for all NTP studies has been updated; you
may search testing status of agents using the following url:
    http://ntp.niehs.nih.gov:8080/index.html?col=010stat
> 
The updated NTP Management Status report for carcinogenicity/toxicity
studies is available at the following url:
    http://ntp.niehs.nih.gov/go/msr

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From ntpmail at list.niehs.nih.gov  Thu Aug 16 14:09:53 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Thu Aug 16 14:10:01 2007
Subject: NTP UPDATE: Dimethylaminopropyl Chloride,
 Hydrochloride Toxicity Report available
Message-ID: <C2EA0B31.129B3%soward@niehs.nih.gov>

The final, TOX-75, National Toxicology Program Toxicity Studies of
Dimethylaminopropyl Chloride, Hydrochloride (CAS No. 5407-04-5) administered
by gavage to F344/N rats and B6C3F1 mice is now available.

See URL:  http://ntp.niehs.nih.gov/go/14372

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From ntpmail at list.niehs.nih.gov  Thu Aug 23 14:18:54 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Thu Aug 23 14:19:23 2007
Subject: NTP UPDATE: NTP Pathology Tables for 1,2-dibromo-2,4-dicyanobutane
Message-ID: <C2F347CE.12CC3%soward@niehs.nih.gov>

The pathology tables for 1,2-Dibromo-2,4-dicyanobutane have been updated and
are available at the NTP website URL:
http://ntp.niehs.nih.gov/go/28622

The complete set of data tables (body weight, clinical observations,
survival, and pathology) for studies planned for peer review are available
on the NTP website at URL:
http://ntp.niehs.nih.gov/go/peerreview

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From ntpmail at list.niehs.nih.gov  Fri Aug 24 14:40:27 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Fri Aug 24 14:40:35 2007
Subject: NTP UPDATE: Udated pathology tables for Dibromoacetonitrile now
	available
Message-ID: <C2F49E5B.12D60%soward@niehs.nih.gov>

The pathology tables for Dibromoacetonitrile have been updated and are
available at the NTP website URL:
http://ntp.niehs.nih.gov/go/28388

The complete set of data tables (body weight, clinical observations,
survival, and pathology) for studies planned for peer review are available
on the NTP website at URL:
http://ntp.niehs.nih.gov/go/peerreview

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From ntpmail at list.niehs.nih.gov  Thu Sep  6 14:48:32 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Thu Sep  6 14:49:02 2007
Subject: NTP UPDATE: Request for Information (RFI): Genetic Variation and
 the Basis
 for Individual Susceptibility to Environmental Toxicant Associated Disease
Message-ID: <C305C3C0.134DC%soward@niehs.nih.gov>

The NTP is currently soliciting information from the extramural and
intramural research communities on the strategies, resources, and tools
necessary to enable this cooperative research program on genetic variation
and individual susceptibility to environmental toxicant exposure and
associated polygenic diseases to progress. The Request for Information
(RFI): Genetic variation and the basis for individual susceptibility to
environmental toxicant associated disease was published today in the NIH
Guide for Grants and Contracts ? see URL:
http://grants.nih.gov/grants/guide/notice-files/NOT-ES-07-009.html

You may respond online to any or all of the questions on the RFI by October
14, 2007 at URL:
http://ntp.niehs.nih.gov/go/32130

You may visit the Host Susceptibility Program website at:
http://ntp.niehs.nih.gov/go/32132
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From ntpmail at list.niehs.nih.gov  Thu Sep  6 14:54:32 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Thu Sep  6 14:54:42 2007
Subject: NTP UPDATE: New Issue of eFactor is now on-line
Message-ID: <C305C528.134E1%soward@niehs.nih.gov>

The September issue of eFactor is now featured on the new NIEHS Website at:

http://www.niehs.nih.gov/news/newsletter/index.cfm

Highlights include:

Trainees Meet NIH Training and Education Director Sharon Milgram

Bisphenol A in the News

Extramural Networks Symposium

Scientific Director Lecture Series: Evan Simpson and Rudy Juliano

NIEHS Extramural Funds Novel Approach to Autism Research

Reports on Lectures by Karen Adelman, Redford Williams and Ken Olden

Mouse Haplotype Published in Nature

September Distinguished Lecturer Susan Cole

Extramural Update

Extramural/Intramural Papers of the Month

Delta Summer Day Camp for Durham Kids

Softball Showdown on Friends and Family Day

Calendar of Upcoming Events

The eFactor welcomes ideas for stories about news items, scientific findings
and employee events.

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From ntpmail at list.niehs.nih.gov  Wed Sep 12 13:58:56 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Wed Sep 12 13:59:26 2007
Subject: NTP UPDATE: Draft murine LLNA performance standards
Message-ID: <C30DA120.13749%soward@niehs.nih.gov>

In today?s Federal Register, the National Toxicology Program (NTP)
Interagency Center for the Evaluation of Alternative Toxicological Methods
(NICEATM) announces the draft performance standards for the murine local
lymph node assay and requests comments.

View the announcement:
http://ntp.niehs.nih.gov/files/LLNA_72_FR_176.pdf

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From ntpmail at list.niehs.nih.gov  Fri Sep 21 14:24:11 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Fri Sep 21 14:24:21 2007
Subject: NTP UPDATE: Updated NTP Testing Status
Message-ID: <C319848B.13C08%soward@niehs.nih.gov>

NTP results & status information for all NTP studies has been updated; you
may search testing status of agents using the following url:
    http://ntp.niehs.nih.gov:8080/index.html?col=010stat
> 
The updated NTP Management Status report for carcinogenicity/toxicity
studies is available at the following url:
    http://ntp.niehs.nih.gov/go/msr

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From ntpmail at list.niehs.nih.gov  Tue Sep 25 15:19:10 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Tue Sep 25 15:19:35 2007
Subject: NTP UPDATE: NTP pathology tables for beta-myrcene
Message-ID: <C31ED76E.5937%soward@niehs.nih.gov>

The pathology tables for beta-Myrcene have been updated and are available at
the NTP website URL:
http://ntp.niehs.nih.gov/go/32145

The complete set of data tables (body weight, clinical observations,
survival, and pathology) for studies planned for peer review are available
on the NTP website at URL:
http://ntp.niehs.nih.gov/go/peerreview

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From ntpmail at list.niehs.nih.gov  Mon Oct  1 13:46:36 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Mon Oct  1 13:47:09 2007
Subject: NTP UPDATE: October eFactor
Message-ID: <C326AABC.1404F%soward@niehs.nih.gov>

The October issue of eFactor is now featured on the new NIEHS Website at:

http://www.niehs.nih.gov/news/newsletter/index.cfm

Highlights include:

NIEHS Advisory Council Meeting/Reports on Trans-NIH Initiatives

Offsite Conferences on Endocrine Disruptors and the Built Environment

Profile ? New Air-Sampling Robot on Red Tide Beach

Reports on Lectures by Susan Cole, Donald Anderson, Shuk-Mei Ho, Dale
Ramsden and Thomas Arcury

Extramural Update; Papers of the Month

Jerry Phelps Peddles from Paris to the Coast of France ? and Back

Calendar of Upcoming Events

The eFactor welcomes ideas for stories about news items, scientific findings
and employee events.

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From ntpmail at list.niehs.nih.gov  Tue Oct  2 14:17:37 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Tue Oct  2 14:17:47 2007
Subject: NTP UPDATE: NTP News Update - October 2007
Message-ID: <C3280381.14114%soward@niehs.nih.gov>

The NTP News Update for October 2007 is now available at URL:
http://ntp.niehs.nih.gov/go/29068

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From ntpmail at list.niehs.nih.gov  Wed Oct  3 14:02:52 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Wed Oct  3 14:03:23 2007
Subject: NTP UPDATE: NTP requests information for Host Susceptibility Program
Message-ID: <C329518C.141C4%soward@niehs.nih.gov>

The National Toxicology Program (NTP) is developing the Host Susceptibility
Program (HSP), a new research program, to identify and functionally validate
genes associated with environmental exposure. This program will make
available NTP expertise and resources to investigate the genetic basis for
population-level differences in susceptibility to environmental toxicants
and/or disease based upon gene and environment interactions.
 
Through a Request for Information (RFI), extramural and intramural
scientists are invited and encouraged to provide information and comment
relevant to this proposed programmatic research approach in order to help
guide further development and refinement of the goals of the NTP HSP.
Information on this initiative can be submitted electronically through the
HSP Request for Information Web site at: ( http://ntp.niehs.nih.gov/go/32130
<http://ntp.niehs.nih.gov/go/32130>  ).
 
Federal Register Notice:
http://ntp.niehs.nih.gov/index.cfm?objectid=6669E0EE-F1F6-975E-7143B489FF38F
631
 
For more information about the NTP Host Susceptibility Program visit:
http://ntp.niehs.nih.gov/go/32132

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From ntpmail at list.niehs.nih.gov  Wed Oct 10 13:48:16 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Wed Oct 10 13:48:46 2007
Subject: NTP UPDATE: NAS Report Offers New Tools to Assess Health Risks from
	Chemicals
In-Reply-To: <C3328765.1449A%soward@niehs.nih.gov>
Message-ID: <C33288A0.1449E%soward@niehs.nih.gov>

Today, the National Academies of Sciences (NAS) announced release (
http://www.nationalacademies.org/morenews/20071009.html ) of the report from
NAS National Research Council entitled ?Applications of Toxicogenomic
Technologies to Predictive Toxicology and Risk Assessment.?  NIEHS
commissioned the NAS report.

> NAS Report Offers New Tools to Assess Health Risks from Chemicals
>  
> Determining how thousands of chemicals found in the environment may be
> interacting with the genes in your body to cause disease is becoming easier
> because of a new field of science called toxicogenomics.  A new report issued
> today by the National Academies of Sciences (NAS) recognizes the importance of
> toxicogenomics in predicting effects on human health and recommends the
> integration of toxicogenomics into regulatory decision making.  The NAS report
> was commissioned by the National Institute of Environmental Health Sciences
> (NIEHS) part of the National Institutes of Health (NIH) and a leader in the
> development of toxicogenomic technologies.
>  
> Toxicogenomic technologies provide tools to better understand the mechanisms
> through which environmental agents initiate and advance disease processes.
> They can also provide important information to help identify individuals that
> are more susceptible to disease risks posed by certain environmental agents
> than the general population.
>  
> ?Using toxicogenomic technologies will open the door for public health
> decision makers who need to decide in a timely and accurate manner what
> chemicals are safe and which ones are not,? says Christopher Portier, Ph.D.,
> Associate Director, NIEHS and Director, Office of Risk Assessment Research.
>       
> The report from the NAS National Research Council (NRC) entitled ?Applications
> of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment?
> states that the technological hurdles that could have limited the
> reproducibility of data from toxicogenomic technologies have been resolved and
> recommends ways for the field to move forward.
>  
>  ?NIH and others have invested in the development of these tools and have
> already tackled many of the tough technical questions.  We are now ready to
> move to the next phase of technology development, refined standardization and
> validation, so these tools can be even more useful to regulatory agencies,?
> says Portier.
>  
> ?The NIEHS and NTP have been steadily increasing the use of toxicogenomic and
> other technologies derived from the molecular biology revolution,? said Samuel
> H. Wilson, M.D., NIEHS Acting Director.  The research and initiatives
> supported through the National Center for Toxicogenomics and the
> Toxicogenomics Research Consortium, for example, were at the forefront of
> these technologies and were leaders in the development of many of the
> standards for quality and reproducibility that are used today.
>  
> The report, which was prepared by a panel of 16 scientists assembled by the
> NRC, provides a broad overview of the potential benefits arising from
> toxicogenomic technologies, describes challenges regarding use of new
> technologies, and provides 14 recommendations to achieve the potential
> benefits of these technologies.
> 
> To read or order the ?Applications of Toxicogenomic Technologies to Predictive
> Toxicology and Assessment? report, please visit
> http://books.nap.edu/catalog.php?record_id=12037.
>  
> 
> The primary mission of the National Institute of Environmental Health Sciences
> ( http://www.niehs.nih.gov/ ) (NIEHS), one of 27 Institutes and Centers at the
> National Institutes of Health, is to reduce the burden of human illness and
> disability by understanding how the environment influences the development and
> progression of human disease. For additional information, visit the NIEHS Web
> site at http://www.niehs.nih.gov/
>  
> The National Toxicology Program (NTP) is an interagency program established in
> 1978 by the Secretary of Health, Education and Welfare, predecessor of the
> U.S. Department of Health and Human Services. The program was created as a
> cooperative effort to coordinate toxicology testing programs within the
> federal government, strengthen the science base in toxicology, develop and
> validate improved testing methods, and provide information about potentially
> toxic chemicals to health, regulatory, and research agencies, scientific and
> medical communities, and the public.
>  
> The National Institutes of Health (NIH) - The Nation?s Medical Research Agency
> - includes 27 Institutes and Centers and is a component of the U. S.
> Department of Health and Human Services. It is the primary federal agency for
> conducting and supporting basic, clinical, and translational medical research,
> and it investigates the causes, treatments, and cures for both common and rare
> diseases. For more information about NIH and its programs, visit
> http://www.nih.gov/
>  
> NIH News Release:  Tuesday, October 9, 2007
>  

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From ntpmail at list.niehs.nih.gov  Mon Oct 15 14:45:34 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Mon Oct 15 14:46:03 2007
Subject: NTP UPDATE: NTP requests information for Host Susceptibility Program
Message-ID: <C3392D8E.146E3%soward@niehs.nih.gov>

Second Announcement

As previously announced, The National Toxicology Program (NTP) is developing
the Host Susceptibility Program (HSP), a new research program, to identify
and functionally validate genes associated with environmental exposure. This
program will make available NTP expertise and resources to investigate the
genetic basis for population-level differences in susceptibility to
environmental toxicants and/or disease based upon gene and environment
interactions.
 
Through a Request for Information (RFI), extramural and intramural
scientists are invited and encouraged to provide information and comment
relevant to this proposed programmatic research approach in order to help
guide further development and refinement of the goals of the NTP HSP. The
deadline for receipt of the information is 31 October 2007.  Information on
this initiative can be submitted electronically through the HSP Request for
Information Web site at:
http://ntp.niehs.nih.gov/go/32130
 
Federal Register Notice:
http://ntp.niehs.nih.gov/index.cfm?objectid=6669E0EE-F1F6-975E-7143B489FF38F
631
 
For more information about the NTP Host Susceptibility Program visit:
http://ntp.niehs.nih.gov/go/32132

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From ntpmail at list.niehs.nih.gov  Thu Oct 18 13:32:46 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Thu Oct 18 13:33:16 2007
Subject: NTP UPDATE: NTP announces December board meeting
Message-ID: <C33D10FE.1496B%soward@niehs.nih.gov>

The National Toxicology Program (NTP) announces the December 6, 2007 meeting
of the NTP Board of Scientific Counselors and requests comments.  Learn more
about the meeting:
http://ntp.niehs.nih.gov/go/165

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From ntpmail at list.niehs.nih.gov  Mon Oct 29 09:49:16 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Mon Oct 29 09:49:25 2007
Subject: NTP UPDATE: NTP Updated Testing Status
Message-ID: <C34B5D1C.14E0D%soward@niehs.nih.gov>

NTP results & status information for all NTP studies has been updated; you
may search testing status of agents using the following url:
    http://ntp.niehs.nih.gov:8080/index.html?col=010stat
> 
The updated NTP Management Status report for carcinogenicity/toxicity
studies is available at the following url:
    http://ntp.niehs.nih.gov/go/msr

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From ntpmail at list.niehs.nih.gov  Thu Nov  1 12:39:19 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Thu Nov  1 12:39:50 2007
Subject: NTP UPDATE: November Environmental Factor now online
Message-ID: <C34F7977.15063%soward@niehs.nih.gov>

The November issue of Environmental Factor is now online at:

http://www.niehs.nih.gov/news/newsletter/index.cfm

Highlights include:

Mason Honored for Lifetime Achievement in Free Radical Biology

Wilson Speaks at Genome Stability Meeting/Trainee Research Highlighted

Meet Sharon Hrynkow, New NIEHS Associate Director

Distinguished Lecturer Andrew Marks on Calcium Regulation

Sister Study Advisory Meeting

IRB Town Meeting

Hispanic Heritage Month Scientific Lectures

National Postdoc Executive Director Visits

Superfund Research on Arsenic, Phytoremediation

Intramural and Extramural Papers of the Month

Disability Awareness Month Speaker

And More?

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From ntpmail at list.niehs.nih.gov  Wed Nov  7 14:36:24 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Wed Nov  7 14:36:54 2007
Subject: NTP UPDATE: Dr. Ron Melnick Earns Rall Award for Environmental
	Health Advocacy
Message-ID: <C3577DE8.15402%soward@niehs.nih.gov>

For his outstanding contributions to public health through science-based
advocacy, Ronald L. Melnick, PhD, received the 2007 David P. Rall Award for
Advocacy in Public Health at the American Public Health Association (APHA)
135th Annual Meeting & Exposition.

Read the full announcement:
http://ntp.niehs.nih.gov/files/Melnick.pdf

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From ntpmail at list.niehs.nih.gov  Tue Nov 13 15:43:42 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Tue Nov 13 15:43:51 2007
Subject: NTP UPDATE: RoC announces expert panel meeting on draft background
	documents
Message-ID: <C35F76AE.156B8%soward@niehs.nih.gov>

The NTP Report on Carcinogens (RoC) announces the availability of draft
background documents on aristolochic acid related exposures (2 candidate
substances) and riddelliine, requests public comment on these draft
documents, and announces the aristolochic acid related exposures and
riddelliine expert panel meeting.  See the Federal Register notice, draft
background documents and  meeting information available on the NTP website:
http://ntp.niehs.nih.gov/go/29679

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From ntpmail at list.niehs.nih.gov  Mon Nov 19 13:56:05 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Mon Nov 19 13:56:23 2007
Subject: NTP UPDATE: NTP pathology tables for bis(2-Chloroethoxy)methane
Message-ID: <C3674675.15B0A%soward@niehs.nih.gov>

The pathology tables for bis(2-Chloroethoxy)methane (rats only) have been
updated and are available at the NTP website URL:
http://ntp.niehs.nih.gov/go/32277

The complete set of data tables (body weight, clinical observations,
survival, and pathology) for studies planned for peer review are available
on the NTP website at URL:
http://ntp.niehs.nih.gov/go/peerreview

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From ntpmail at list.niehs.nih.gov  Mon Nov 26 10:33:07 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Mon Nov 26 10:33:37 2007
Subject: NTP UPDATE: NICEATM announces availability of report and background
 review documents
Message-ID: <C3705163.15D84%soward@niehs.nih.gov>

In today?s Federal Register, the National Toxicology Program (NTP)
Interagency Center for the Evaluation of Alternative Toxicological Methods
(NICEATM) announces the availability of the Interagency Coordinating
Committee on the Validation of Alternative Methods (ICCVAM) Test Method
Evaluation Report on In Vitro Ocular Toxicity Test Methods for Identifying
Severe Irritants and Corrosives and Final In Vitro Ocular Test Method
Background Review Documents; Notice of Transmittal of ICCVAM Test Method
Recommendations to Federal Agencies.

View the announcement:
http://ntp.niehs.nih.gov/files/NICEATM_72_FR_226.pdf

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From ntpmail at list.niehs.nih.gov  Tue Nov 27 14:23:43 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Tue Nov 27 14:23:52 2007
Subject: NTP UPDATE: Genetically Modified Model Report on Benzene now
	available
Message-ID: <C371D8EF.15E92%soward@niehs.nih.gov>

The final, GMM-08, National Toxicology Program Genetically Modified Model
Report on the Toxicology and Carcinogenesis Study of Benzene (CAS No.
71-43-2) administered by gavage to genetically modified Haploinsufficient
p16[Inka4a]/p19[Arf] mice is now available.

See URL: http://ntp.niehs.nih.gov/go/28483

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From ntpmail at list.niehs.nih.gov  Wed Nov 28 11:56:30 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Wed Nov 28 11:56:59 2007
Subject: NTP UPDATE: Updates to the NTP Website
Message-ID: <C37307EE.15F65%soward@niehs.nih.gov>

The following final reports are now available on the NTP website:
> 
> GMM-9: National Toxicology Program Genetically Modified Model Report on the
> Toxicology Studies of Dicyclohexylcarbodiimide (CAS No. 538-75-0) in F344/N
> Rats, B6C3F1 Mice, and Genetically Modified (FVB Tg.AC Hemizygous) Mice and
> Carcinogenicity Study of Dicyclohexylcarbodiimide in Genetically Modified
> [B6.129-Trp53[tm1Brd] (N5) Haploinsufficient] Mice (Dermal Studies)
> See URL:  http://ntp.niehs.nih.gov/go/28490
> 
> TOX-62: National Toxicology Program Toxicity Report on the Toxicity Studies of
> Wy-14,643 (CAS No. 50892-23-4) administered in Feed to Male Sprague-Dawley
> Rats, B6C3F1 Mice, and Syrian Hamsters
> See URL:  http://ntp.niehs.nih.gov/go/32492
> 
* Updated Testing Status:

> NTP results & status information for all NTP studies has been updated; you may
> search testing status of agents using the following url:
>     http://ntp.niehs.nih.gov:8080/index.html?col=010stat
> 
> The updated NTP Management Status report for carcinogenicity/toxicity studies
> is available at the following url:
>     http://ntp.niehs.nih.gov/go/msr
> 

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From ntpmail at list.niehs.nih.gov  Fri Nov 30 13:57:02 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Fri Nov 30 13:57:41 2007
Subject: NTP UPDATE: Final expert panel report for bisphenol A evaluation is
 now available; request for comments
Message-ID: <C375C72E.160B8%soward@niehs.nih.gov>

In today?s Federal Register, NTP-CERHR announced the availability of the
final expert panel report for bisphenol A (BPA) evaluation and request for
public comments.

View the FR notice at URL:
http://ntp.niehs.nih.gov/files/BPA_Fnl_72_FR_230.pdf
<http://ntp.niehs.nih.gov/files/BPA_Fnl_72_FR_230.pdf>

BPA Final Expert Panel Report ? see URL:
http://cerhr.niehs.nih.gov/chemicals/bisphenol/BPAFinalEPVF112607.pdf

BPA Evaluation page ? see URL:
http://cerhr.niehs.nih.gov/chemicals/bisphenol/bisphenol-eval.html
<http://cerhr.niehs.nih.gov/chemicals/bisphenol/bisphenol-eval.html>

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From ntpmail at list.niehs.nih.gov  Mon Dec  3 15:13:28 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Mon Dec  3 15:13:57 2007
Subject: NTP UPDATE: December Environmental Factor now online
Message-ID: <C379CD98.16214%soward@niehs.nih.gov>

The December Issue of the Environmental Factor is now online at:
http://www.niehs.nih.gov/news/newsletter/index.cfm

Highlights include:

Aging Symposium Features NIEHS and NIA Scientists

ONES Grantee Honored at White House

Science Day Honors Trainees and Investigators

Summer Intern Joins Mentor at TIES Bioinformatics/Genomics Conference

Melnick Gets APHA Rall Award

Kastan Delivers Falk Lecture

GEMS Turns 25 at Fall Meeting

Superfund Grantee Di Giulio Speaks

Gene Expression and Acetaminophen OD

New Editor-In-Chief for EHP

Suk Leads NIEHS Global Health Delegation in Asia

Friedberg to Give Distinguished Lecture Native American Heritage Event
Features Cherokee Historian

Wilson Kicks Off Mix and Mingle Series

O?Fallon Runs and Rides in World Competition

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From ntpmail at list.niehs.nih.gov  Thu Dec 13 10:49:47 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Thu Dec 13 10:50:19 2007
Subject: NTP UPDATE: NTP announces February BSC Technical Report Review
 Subcommittee Meeting
Message-ID: <C386BECB.167FD%soward@niehs.nih.gov>

In today?s Federal Register:

The National Toxicology Program (NTP) Office of Liaison, Policy and Review
announces the February 27-28, 2008 meeting of the NTP Board of Scientific
Counselors Technical Reports Review Subcommittee and requests comments.

View the Federal Register notice:
http://ntp.niehs.nih.gov/files/TRRS_72_FR_239.pdf

Meeting Page:  http://ntp.niehs.nih.gov/mtg?date=20080127&meeting=TRRS

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From ntpmail at list.niehs.nih.gov  Fri Dec 21 14:00:25 2007
From: ntpmail at list.niehs.nih.gov (ntpmail@list.niehs.nih.gov)
Date: Fri Dec 21 14:00:31 2007
Subject: NTP UPDATE: News from the NTP
Message-ID: <C3917779.758F%soward@niehs.nih.gov>

* In today?s Federal Register

> The NTP Interagency Center for the Evaluation of Alternative Toxicological
> Methods (NICEATM); Interagency Coordinating Committee on the Validation of
> Alternative Methods (ICCVAM):  Ten-Year Anniversary Symposium nad Five-Year
> Plan ? announcement of public symposium and availability of document.
> 
> Federal Register Notice URL:
> http://ntp.niehs.nih.gov/ntpweb/index.cfm?objectid=FCF6EDFF-F1F6-975E-7F04C92D
> 3F08ED25
> 
> Meeting page:
> http://iccvam.niehs.nih.gov/meetings/10thAnnivSymp/10thAnnivSymp.htm

* Updated Testing Status:

> NTP results & status information for all NTP studies has been updated; you may
> search testing status of agents using the following url:
>     http://ntp.niehs.nih.gov:8080/index.html?col=010stat
>  
> The updated NTP Management Status report for carcinogenicity/toxicity studies
> is available at the following url:
>     http://ntp.niehs.nih.gov/go/msr

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