BLASTP 2.0.8 [Jan-05-1999]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= YOR202W HIS3, Chr XV from 721944-722606
         (220 letters)

Database: nr
           361,503 sequences; 110,384,460 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

gi|2506514|sp|P06633|HIS7_YEAST IMIDAZOLEGLYCEROL-PHOSPHATE DEH...   442  e-124
gi|3780|emb|CAA27003| (X03245) imidazoleglycerolphosphate dehyd...   432  e-120
gi|399897|sp|Q02986|HIS7_SACKL IMIDAZOLEGLYCEROL-PHOSPHATE DEHY...   379  e-105
gi|2495229|sp|Q92447|HIS7_PICPA IMIDAZOLEGLYCEROL-PHOSPHATE DEH...   346  1e-94
gi|3810733|emb|CAA73207| (Y12658) imidazoleglycerol-phosphate d...   343  7e-94
gi|2495227|sp|P56090|HIS7_CANAL IMIDAZOLEGLYCEROL-PHOSPHATE DEH...   333  8e-91
gi|2495228|sp|Q12578|HIS7_CANGA IMIDAZOLEGLYCEROL-PHOSPHATE DEH...   322  1e-87
gi|462274|sp|P34041|HIS7_TRIHA IMIDAZOLEGLYCEROL-PHOSPHATE DEHY...   277  3e-74
gi|729719|sp|P40374|HIS7_SCHPO IMIDAZOLEGLYCEROL-PHOSPHATE DEHY...   271  3e-72
gi|2688968 (AF027980) imidazole glycerol phosphate dehydratase ...   268  2e-71
gi|4262548|gb|AAD14685| (AF114492) imidazolglycerolphosphate-hy...   247  4e-65
gi|729718|sp|P40919|HIS7_CRYNE IMIDAZOLEGLYCEROL-PHOSPHATE DEHY...   240  6e-63
gi|100993|pir||S22199 imidazoleglycerol-phosphate dehydratase (...   213  6e-55
gi|123159|sp|P28624|HIS7_PHYPR IMIDAZOLEGLYCEROL-PHOSPHATE DEHY...   212  1e-54
gi|123157|sp|P18787|HIS7_AZOBR IMIDAZOLEGLYCEROL-PHOSPHATE DEHY...   178  4e-44
gi|2495230|sp|Q43072|HIS7_PEA IMIDAZOLEGLYCEROL-PHOSPHATE DEHYD...   162  1e-39
gi|2495226|sp|Q50504|HIS7_METTH PROBABLE IMIDAZOLEGLYCEROL-PHOS...   161  3e-39
gi|2622582 (AE000908) imidazoleglycerol-phosphate dehydratase [...   161  3e-39
gi|3982576 (AF023140) imidazoleglycerol phosphate dehydratase [...   158  3e-38
gi|462273|sp|P34047|HIS7_ARATH IMIDAZOLEGLYCEROL-PHOSPHATE DEHY...   158  3e-38
gi|2398791|emb|CAA60712| (X87256) imidazoleglycerol-phosphate d...   157  4e-38
gi|2244848|emb|CAB10270| (Z97337) imidazoleglycerol-phosphate d...   157  8e-38
gi|123158|sp|P06987|HIS7_ECOLI IMIDAZOLEGLYCEROL-PHOSPHATE DEHY...   156  1e-37
gi|1736709|gnl|PID|d1016585 (D90841) HisB bifunctional enzyme [...   156  1e-37
gi|1788333 (AE000293) imidazoleglycerolphosphate dehydratase an...   156  1e-37
gi|2618867 (AF017113) imidazoleglycerol-phosphate dehydratase [...   156  1e-37
gi|551331 (U02690) imidazoleglycerolphosphate dehydratase [Trit...   155  2e-37
gi|462275|sp|P34048|HIS7_WHEAT IMIDAZOLEGLYCEROL-PHOSPHATE DEHY...   155  2e-37
gi|1170286|sp|P44327|HIS7_HAEIN IMIDAZOLEGLYCEROL-PHOSPHATE DEH...   155  3e-37
gi|1346293|sp|P48054|HIS7_SYNY3 IMIDAZOLEGLYCEROL-PHOSPHATE DEH...   155  3e-37
gi|4038317 (AF067228) imidazoleglycerolphosphate dehydratase/ h...   152  3e-36
gi|2982780 (AE000670) imidazoleglycerolphosphate dehydratase [A...   151  3e-36
gi|462272|sp|Q05068|HIS7_ANASP IMIDAZOLEGLYCEROL-PHOSPHATE DEHY...   148  2e-35
gi|123161|sp|P16247|HIS7_STRCO IMIDAZOLEGLYCEROL-PHOSPHATE DEHY...   146  1e-34
gi|123160|sp|P10368|HIS7_SALTY IMIDAZOLEGLYCEROL-PHOSPHATE DEHY...   142  2e-33
gi|1333842|emb|CAA31825| (X13464) hisB ORF (AA 1-353) [Salmonel...   142  2e-33
gi|2495224|sp|O06590|HIS7_MYCTU IMIDAZOLEGLYCEROL-PHOSPHATE DEH...   140  8e-33
gi|3334215|sp|O33773|HIS7_SULSO PROBABLE IMIDAZOLEGLYCEROL-PHOS...   140  8e-33
gi|2495225|sp|Q58109|HIS7_METJA PROBABLE IMIDAZOLEGLYCEROL-PHOS...   136  2e-31
gi|399896|sp|Q02134|HIS7_LACLA IMIDAZOLEGLYCEROL-PHOSPHATE DEHY...   122  2e-27
gi|2649620 (AE001036) imidazoleglycerol-phosphate dehydrogenase...   110  9e-24
gi|1197052 (J01330) imidazoleglycerolphosphate dehydratase [Sac...    65  5e-10

>gi|2506514|sp|P06633|HIS7_YEAST IMIDAZOLEGLYCEROL-PHOSPHATE
           DEHYDRATASE (IGPD) >gi|2144537|pir||DWBYH
           imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) -
           yeast (Saccharomyces cerevisiae)
           >gi|1420477|emb|CAA99417| (Z75110) ORF YOR202w
           [Saccharomyces cerevisiae]
           Length = 220
           
 Score =  442 bits (1125), Expect = e-124
 Identities = 220/220 (100%), Positives = 220/220 (100%)

Query: 1   MTEQKALVKRITNETKIQIAISLKGGPLAIEHSIFPEKEAEAVAEQATQSQVINVHTGIG 60
           MTEQKALVKRITNETKIQIAISLKGGPLAIEHSIFPEKEAEAVAEQATQSQVINVHTGIG
Sbjct: 1   MTEQKALVKRITNETKIQIAISLKGGPLAIEHSIFPEKEAEAVAEQATQSQVINVHTGIG 60

Query: 61  FLDHMIHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRGVKRFGSG 120
           FLDHMIHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRGVKRFGSG
Sbjct: 61  FLDHMIHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRGVKRFGSG 120

Query: 121 FAPLDEALSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRITLHVDCL 180
           FAPLDEALSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRITLHVDCL
Sbjct: 121 FAPLDEALSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRITLHVDCL 180

Query: 181 RGKNDHHRSESAFKALAVAIREATSPNGTNDVPSTKGVLM 220
           RGKNDHHRSESAFKALAVAIREATSPNGTNDVPSTKGVLM
Sbjct: 181 RGKNDHHRSESAFKALAVAIREATSPNGTNDVPSTKGVLM 220


>gi|3780|emb|CAA27003| (X03245) imidazoleglycerolphosphate
           dehydratase (his3) (aa 1-219) [Saccharomyces cerevisiae]
           >gi|408370 (U01086) imidazoleglycerolphosphate
           dehydratase (HIS3) [synthetic construct] >gi|2190695
           (U89927) HIS3 [Cloning vector pHISi] >gi|2190699
           (U89928) HIS3 [Cloning vector pHISi-1] >gi|2293119
           (U89960) imidazoleglycerolphosphate dehydratase [Cloning
           vector pEG202]
           Length = 219
           
 Score =  432 bits (1099), Expect = e-120
 Identities = 218/220 (99%), Positives = 218/220 (99%), Gaps = 1/220 (0%)

Query: 1   MTEQKALVKRITNETKIQIAISLKGGPLAIEHSIFPEKEAEAVAEQATQSQVINVHTGIG 60
           MTEQKALVKRITNETKIQIAISLKGGPLAIEHSIFPEKEAEAVAEQATQSQVINVHTGIG
Sbjct: 1   MTEQKALVKRITNETKIQIAISLKGGPLAIEHSIFPEKEAEAVAEQATQSQVINVHTGIG 60

Query: 61  FLDHMIHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRGVKRFGSG 120
           FLDHMIHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEAL A RGVKRFGSG
Sbjct: 61  FLDHMIHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALLA-RGVKRFGSG 119

Query: 121 FAPLDEALSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRITLHVDCL 180
           FAPLDEALSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRITLHVDCL
Sbjct: 120 FAPLDEALSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRITLHVDCL 179

Query: 181 RGKNDHHRSESAFKALAVAIREATSPNGTNDVPSTKGVLM 220
           RGKNDHHRSESAFKALAVAIREATSPNGTNDVPSTKGVLM
Sbjct: 180 RGKNDHHRSESAFKALAVAIREATSPNGTNDVPSTKGVLM 219


>gi|399897|sp|Q02986|HIS7_SACKL IMIDAZOLEGLYCEROL-PHOSPHATE
           DEHYDRATASE (IGPD) >gi|320134|pir||S31235
           imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) -
           yeast (Saccharomyces kluyveri) >gi|4865|emb|CAA78497|
           (Z14125) imidazoleglycerol phosphate dehydratase
           [Saccharomyces kluyveri]
           Length = 232
           
 Score =  379 bits (964), Expect = e-105
 Identities = 185/218 (84%), Positives = 202/218 (91%)

Query: 3   EQKALVKRITNETKIQIAISLKGGPLAIEHSIFPEKEAEAVAEQATQSQVINVHTGIGFL 62
           E+KA + RITNETKIQIAISL GG + I+ SI P K+ + VA QATQSQVI++HTG+GFL
Sbjct: 15  ERKAFISRITNETKIQIAISLNGGYIQIKDSILPAKKDDDVASQATQSQVIDIHTGVGFL 74

Query: 63  DHMIHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRGVKRFGSGFA 122
           DHMIHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEA+GAVRGVKRFG+GFA
Sbjct: 75  DHMIHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEAMGAVRGVKRFGTGFA 134

Query: 123 PLDEALSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRITLHVDCLRG 182
           PLDEALSRAVVDLSNRP+AV++LGL+RE +GDLS EMIPHFLESFAEA+RITLHVDCLRG
Sbjct: 135 PLDEALSRAVVDLSNRPFAVIDLGLKREMIGDLSTEMIPHFLESFAEAARITLHVDCLRG 194

Query: 183 KNDHHRSESAFKALAVAIREATSPNGTNDVPSTKGVLM 220
            NDHHRSESAFKALAVAIREA S NGTNDVPSTKGVLM
Sbjct: 195 FNDHHRSESAFKALAVAIREAISSNGTNDVPSTKGVLM 232


>gi|2495229|sp|Q92447|HIS7_PICPA IMIDAZOLEGLYCEROL-PHOSPHATE
           DEHYDRATASE (IGPD) >gi|1658376 (U69170) imidazole
           glycerolphosphate dehydratase [Pichia pastoris]
           Length = 224
           
 Score =  346 bits (877), Expect = 1e-94
 Identities = 162/218 (74%), Positives = 195/218 (89%), Gaps = 1/218 (0%)

Query: 3   EQKALVKRITNETKIQIAISLKGGPLAIEHSIFPEKEAEAV-AEQATQSQVINVHTGIGF 61
           ++ +L+KRITNETKIQIA+SL GGP+++  S+F +K+  A  A QAT SQ I+V+TGIGF
Sbjct: 6   KRSSLIKRITNETKIQIALSLDGGPVSLAQSLFKDKDYSAEHAAQATSSQFISVNTGIGF 65

Query: 62  LDHMIHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRGVKRFGSGF 121
           LDHM+HALAKH GWS+I+EC+GDLHIDDHH+ ED GIALG AFKEALG VRG+KRFGSGF
Sbjct: 66  LDHMLHALAKHGGWSVIIECVGDLHIDDHHSAEDTGIALGMAFKEALGHVRGIKRFGSGF 125

Query: 122 APLDEALSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRITLHVDCLR 181
           APLDEALSRAV+D+SNRPYAVV+LGL+REK+GDLSCEMIPH LESFA+ + +T+HVDCLR
Sbjct: 126 APLDEALSRAVIDMSNRPYAVVDLGLKREKIGDLSCEMIPHVLESFAQGAHVTMHVDCLR 185

Query: 182 GKNDHHRSESAFKALAVAIREATSPNGTNDVPSTKGVL 219
           G NDHHR+ESAFKALA+AI+EA S NGT+D+PSTKGVL
Sbjct: 186 GFNDHHRAESAFKALAIAIKEAISSNGTDDIPSTKGVL 223


>gi|3810733|emb|CAA73207| (Y12658) imidazoleglycerol-phosphate
           dehydratase [Candida utilis]
           Length = 224
           
 Score =  343 bits (870), Expect = 7e-94
 Identities = 170/217 (78%), Positives = 193/217 (88%), Gaps = 2/217 (0%)

Query: 3   EQKALVKRITNETKIQIAISLKGGPLAIEHSIFPEKEAEAVAEQATQSQVINVHTGIGFL 62
           +++ALV R TNETKIQI++SL GG + +  SIF +K+ +  A Q T SQVI+++TG+GFL
Sbjct: 9   QRRALVNRTTNETKIQISLSLDGGYVTVPESIFKDKKYDD-ATQVTSSQVISINTGVGFL 67

Query: 63  DHMIHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRGVKRFGSGFA 122
           DHMIHALAKH GWSLIVECIGDLHIDDHHTTED GIALG A KEAL A RGVKRFGSGFA
Sbjct: 68  DHMIHALAKHGGWSLIVECIGDLHIDDHHTTEDVGIALGDAVKEAL-AYRGVKRFGSGFA 126

Query: 123 PLDEALSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRITLHVDCLRG 182
           PLDEALSRAVVDLSNRP+AVVELGL+REK+GDLSCEMIPHFLESFA+A+ IT+HVDCLRG
Sbjct: 127 PLDEALSRAVVDLSNRPFAVVELGLKREKIGDLSCEMIPHFLESFAQAAHITMHVDCLRG 186

Query: 183 KNDHHRSESAFKALAVAIREATSPNGTNDVPSTKGVL 219
            NDHHR+ESAFKALAVAI+E+ S NGTNDVPSTKGVL
Sbjct: 187 FNDHHRAESAFKALAVAIKESISSNGTNDVPSTKGVL 223


>gi|2495227|sp|P56090|HIS7_CANAL IMIDAZOLEGLYCEROL-PHOSPHATE
           DEHYDRATASE (IGPD) >gi|2226092 (AF006605) imidazole
           glycerol phosphate dehydratase [Candida albicans]
           Length = 223
           
 Score =  333 bits (844), Expect = 8e-91
 Identities = 164/219 (74%), Positives = 187/219 (84%), Gaps = 3/219 (1%)

Query: 4   QKALVKRITNETKIQIAISLKGGPLAIEHSIFPEKEA---EAVAEQATQSQVINVHTGIG 60
           ++AL+ RITNETKIQIA++L GG L ++ SIFP +     E  A+Q + SQ INV TGIG
Sbjct: 3   REALINRITNETKIQIALNLDGGKLELKESIFPNQSIIIDEHHAKQVSGSQYINVQTGIG 62

Query: 61  FLDHMIHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRGVKRFGSG 120
           FLDHMIHALAKHSGWSLIVECIGDLHIDDHHT ED GI+LG AFK+ALG ++GVKRFG G
Sbjct: 63  FLDHMIHALAKHSGWSLIVECIGDLHIDDHHTAEDVGISLGMAFKQALGQIKGVKRFGHG 122

Query: 121 FAPLDEALSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRITLHVDCL 180
           FAPLDEALSRAVVDLSNRP+AV+ELGL+REK+GDLS EMIPH LESFA A  IT+HVDCL
Sbjct: 123 FAPLDEALSRAVVDLSNRPFAVIELGLKREKIGDLSTEMIPHVLESFAGAVGITIHVDCL 182

Query: 181 RGKNDHHRSESAFKALAVAIREATSPNGTNDVPSTKGVL 219
           RG NDHHR+ESAFKALA+AI+EA S  G ND+PSTKGVL
Sbjct: 183 RGFNDHHRAESAFKALAIAIKEAISKTGKNDIPSTKGVL 221


>gi|2495228|sp|Q12578|HIS7_CANGA IMIDAZOLEGLYCEROL-PHOSPHATE
           DEHYDRATASE (IGPD) >gi|2118309|pir||JC4381
           imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) -
           yeast (Candida glabrata) >gi|1098631 (U31470)
           imidazoleglycerolphosphate dehydratase [Candida
           glabrata] >gi|4008107 (AF107116)
           imidazoleglycerol-phosphate dehydratase [Candida
           glabrata]
           Length = 210
           
 Score =  322 bits (816), Expect = 1e-87
 Identities = 155/214 (72%), Positives = 177/214 (82%), Gaps = 6/214 (2%)

Query: 6   ALVKRITNETKIQIAISLKGGPLAIEHSIFPEKEAEAVAEQATQSQVINVHTGIGFLDHM 65
           A VKR+T ET IQ+A+ L GG +++  SI  ++ A          Q I+VHTG+GFLDHM
Sbjct: 2   AFVKRVTQETNIQLALDLDGGSVSVRESILGKEYASG------DGQTIHVHTGVGFLDHM 55

Query: 66  IHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRGVKRFGSGFAPLD 125
           + ALAKH GWSLI+ECIGDLHIDDHHT EDCGIALGQAFKEALG+VRG+KRFG GFAPLD
Sbjct: 56  LTALAKHGGWSLILECIGDLHIDDHHTVEDCGIALGQAFKEALGSVRGIKRFGHGFAPLD 115

Query: 126 EALSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRITLHVDCLRGKND 185
           EALSRAVVD SNRP+AVVELGL+RE++G LS EMIPHFLESFA   RIT+HVDCLRG ND
Sbjct: 116 EALSRAVVDFSNRPFAVVELGLKRERIGQLSTEMIPHFLESFATEGRITMHVDCLRGTND 175

Query: 186 HHRSESAFKALAVAIREATSPNGTNDVPSTKGVL 219
           HHRSES FKALA+AIREA +P G +DVPSTKGVL
Sbjct: 176 HHRSESGFKALAIAIREARTPTGRDDVPSTKGVL 209


>gi|462274|sp|P34041|HIS7_TRIHA IMIDAZOLEGLYCEROL-PHOSPHATE
           DEHYDRATASE (IGPD) >gi|280495|pir||S26196
           imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) -
           fungus (Trichoderma harzianum) >gi|5177|emb|CAA77617|
           (Z11528) imidazoleglycerolphosphate [Trichoderma
           harzianum]
           Length = 208
           
 Score =  277 bits (702), Expect = 3e-74
 Identities = 134/196 (68%), Positives = 162/196 (82%)

Query: 6   ALVKRITNETKIQIAISLKGGPLAIEHSIFPEKEAEAVAEQATQSQVINVHTGIGFLDHM 65
           A + R TNET IQIA+S+ GG L  +      + + A A Q ++SQVI+++TGIGFLDHM
Sbjct: 10  AALSRDTNETSIQIALSIDGGELPQDADPRLLEASSAHASQTSKSQVISINTGIGFLDHM 69

Query: 66  IHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRGVKRFGSGFAPLD 125
           +HALAKH+GWS+ + C GDLHIDDHHT EDC IA+G  F +ALGA+ GV RFG  +APLD
Sbjct: 70  LHALAKHAGWSMALNCKGDLHIDDHHTAEDCCIAVGTTFAKALGALTGVARFGYAYAPLD 129

Query: 126 EALSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRITLHVDCLRGKND 185
           EALSRAVVDLSNRPY VV+LGL+REK+G+LSCEMIPH L+SFA+A+RITLHVDCLRG ND
Sbjct: 130 EALSRAVVDLSNRPYTVVDLGLKREKLGELSCEMIPHCLQSFAQAARITLHVDCLRGDND 189

Query: 186 HHRSESAFKALAVAIR 201
           HHR+ESAFKALAVA+R
Sbjct: 190 HHRAESAFKALAVAVR 205


>gi|729719|sp|P40374|HIS7_SCHPO IMIDAZOLEGLYCEROL-PHOSPHATE
           DEHYDRATASE (IGPD) >gi|2130457|pir||S55077
           imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) -
           fission yeast (Schizosaccharomyces pombe) >gi|476142
           (U07831) imidazoleglycerol-phosphate dehydratase
           [Schizosaccharomyces pombe] >gi|3116116|emb|CAA18867|
           (AL023286) imidazoleglycerol-phosphate dehydratase
           [Schizosaccharomyces pombe]
           Length = 216
           
 Score =  271 bits (686), Expect = 3e-72
 Identities = 140/216 (64%), Positives = 165/216 (75%), Gaps = 1/216 (0%)

Query: 4   QKALVKRITNETKIQIAISLKGGPLAIEHSIFPEKEAEAVAEQATQSQVINVHTGIGFLD 63
           ++A V+R TNETKI +AI+L   PL  E +   E      A Q  + QVI V TGIGFLD
Sbjct: 2   RRAFVERNTNETKISVAIALDKAPLPEESNFIDELITSKHANQKGE-QVIQVDTGIGFLD 60

Query: 64  HMIHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRGVKRFGSGFAP 123
           HM HALAKH+GWSL +   GDL IDDHHT ED  IALG AFK+A+G   GVKRFG  + P
Sbjct: 61  HMYHALAKHAGWSLRLYSRGDLIIDDHHTAEDTAIALGIAFKQAMGNFAGVKRFGHAYCP 120

Query: 124 LDEALSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRITLHVDCLRGK 183
           LDEALSR+VVDLS RPYAV++LGL+REKVG+LSCEMIPH L SF+ A+ ITLHV CL G 
Sbjct: 121 LDEALSRSVVDLSGRPYAVIDLGLKREKVGELSCEMIPHLLYSFSVAAGITLHVTCLYGS 180

Query: 184 NDHHRSESAFKALAVAIREATSPNGTNDVPSTKGVL 219
           NDHHR+ESAFK+LAVA+R ATS  G+++VPSTKGVL
Sbjct: 181 NDHHRAESAFKSLAVAMRAATSLTGSSEVPSTKGVL 216


>gi|2688968 (AF027980) imidazole glycerol phosphate dehydratase
           [Magnaporthe grisea]
           Length = 227
           
 Score =  268 bits (678), Expect = 2e-71
 Identities = 129/199 (64%), Positives = 161/199 (80%), Gaps = 1/199 (0%)

Query: 6   ALVKRITNETKIQIAISLKGGPLAIE-HSIFPEKEAEAVAEQATQSQVINVHTGIGFLDH 64
           A + R TNETK+++A+S+ GG L  + H    E  A   A Q++ SQ I+++TGIGFLDH
Sbjct: 7   AALARDTNETKVKLALSIDGGDLPPDTHPSLLEAAASGHASQSSSSQKISINTGIGFLDH 66

Query: 65  MIHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRGVKRFGSGFAPL 124
           M+HA AKH+G+SL++ C GDLHIDDHHT ED  IALG AFK ALG+  G+ RFG  + PL
Sbjct: 67  MLHAFAKHAGFSLLLTCQGDLHIDDHHTAEDVCIALGDAFKTALGSAAGIARFGFAYCPL 126

Query: 125 DEALSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRITLHVDCLRGKN 184
           DEALSRAVVD+SNRP+AVVELGL+REK+GDLSCEMIPH + SFA A+R+T+HVDC+RG+N
Sbjct: 127 DEALSRAVVDVSNRPFAVVELGLRREKIGDLSCEMIPHCIMSFATAARLTIHVDCIRGEN 186

Query: 185 DHHRSESAFKALAVAIREA 203
           DHHR+ESAFKALAVA+R A
Sbjct: 187 DHHRAESAFKALAVAVRTA 205


>gi|4262548|gb|AAD14685| (AF114492)
           imidazolglycerolphosphate-hydratase [Phaffia rhodozyma]
           Length = 205
           
 Score =  247 bits (625), Expect = 4e-65
 Identities = 124/215 (57%), Positives = 154/215 (70%), Gaps = 19/215 (8%)

Query: 6   ALVKRITNETKIQIAISLKGGPLAIEHSIFPEKEAEAVAEQATQSQVINVHTGIGFLDHM 65
           A V R TNET+I  +ISL   P                       Q+I++ TGIGFL+HM
Sbjct: 10  ATVTRNTNETQIVCSISLDHTP-------------------GVDQQIIDIQTGIGFLNHM 50

Query: 66  IHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRGVKRFGSGFAPLD 125
           +HA+AKH   SL + C GDL IDDHHT EDC +ALG+AFK ALG  RG++R+G+GFAPLD
Sbjct: 51  LHAMAKHGNMSLTLHCKGDLEIDDHHTAEDCALALGEAFKLALGERRGIRRYGTGFAPLD 110

Query: 126 EALSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRITLHVDCLRGKND 185
           EALSRAV+D+S+RPY   +L   REK+GDLS EMIPH  ESFA A+ +TLHVDC+RG N+
Sbjct: 111 EALSRAVLDISSRPYFCGDLPFTREKIGDLSTEMIPHVFESFATAAGVTLHVDCIRGVNN 170

Query: 186 HHRSESAFKALAVAIREATSPNGTNDVPSTKGVLM 220
           HH +E++FKALA+AIREA +  G NDVPSTKGVL+
Sbjct: 171 HHIAEASFKALALAIREAITRTGGNDVPSTKGVLL 205


>gi|729718|sp|P40919|HIS7_CRYNE IMIDAZOLEGLYCEROL-PHOSPHATE
           DEHYDRATASE (IGPD) >gi|506636 (U04329) imidazole
           glycerol phosphate dehydratase [Filobasidiella
           neoformans]
           Length = 202
           
 Score =  240 bits (606), Expect = 6e-63
 Identities = 125/219 (57%), Positives = 154/219 (70%), Gaps = 19/219 (8%)

Query: 1   MTEQKALVKRITNETKIQIAISLKGGPLAIEHSIFPEKEAEAVAEQATQSQVINVHTGIG 60
           M+E+ A V+R T+ET I   I L   P   E                   Q INV TGIG
Sbjct: 1   MSERIASVERTTSETHISCTIDLDHIPGVTE-------------------QKINVSTGIG 41

Query: 61  FLDHMIHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRGVKRFGSG 120
           FLDHM  ALAKH G SL ++C GDLHIDDHHT EDC +ALG+AFK+ALG  +G+KR+G  
Sbjct: 42  FLDHMFTALAKHGGMSLQLQCKGDLHIDDHHTAEDCALALGEAFKKALGERKGIKRYGYA 101

Query: 121 FAPLDEALSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRITLHVDCL 180
           +APLDE+LSRAV+D+S+RPY +  L   REKVGDLS EM+ H L+SFA A+ +TLH+D +
Sbjct: 102 YAPLDESLSRAVIDISSRPYFMCHLPFTREKVGDLSTEMVSHLLQSFAFAAGVTLHIDSI 161

Query: 181 RGKNDHHRSESAFKALAVAIREATSPNGTNDVPSTKGVL 219
           RG+N+HH +ESAFKALA+AIR A S  G +DVPSTKGVL
Sbjct: 162 RGENNHHIAESAFKALALAIRMAISRTGGDDVPSTKGVL 200


>gi|100993|pir||S22199 imidazoleglycerol-phosphate dehydratase (EC
           4.2.1.19) - potato buckeye rot agent
           Length = 452
           
 Score =  213 bits (538), Expect = 6e-55
 Identities = 112/216 (51%), Positives = 142/216 (64%), Gaps = 24/216 (11%)

Query: 4   QKALVKRITNETKIQIAISLKGGPLAIEHSIFPEKEAEAVAEQATQSQVINVHTGIGFLD 63
           ++A + R+T ET I + +SL G   +                         V +GIGFLD
Sbjct: 260 REANISRVTKETSISVKLSLDGTGKS------------------------KVSSGIGFLD 295

Query: 64  HMIHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRGVKRFGSGFAP 123
           HM+ ALAKHS + L ++C GD  IDDHHTTEDC + LG+AF  ALG   G+ RFGS   P
Sbjct: 296 HMLTALAKHSRFDLELDCKGDTWIDDHHTTEDCALTLGEAFDVALGDRAGIARFGSACVP 355

Query: 124 LDEALSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRITLHVDCLRGK 183
           LDEALSRA+VD+S+R ++ + L L R  VG+LS EMI HF ESFA A+ +TLHVD LRG+
Sbjct: 356 LDEALSRAIVDISSRAHSEINLQLVRPSVGELSSEMITHFFESFASAALLTLHVDVLRGR 415

Query: 184 NDHHRSESAFKALAVAIREATSPNGTNDVPSTKGVL 219
           NDHHR+E++FKALAVA+R A   + T  VPSTKGVL
Sbjct: 416 NDHHRAEASFKALAVALRTAVKHDATAGVPSTKGVL 451


>gi|123159|sp|P28624|HIS7_PHYPR IMIDAZOLEGLYCEROL-PHOSPHATE
           DEHYDRATASE (IGPD) >gi|3198|emb|CAA77675| (Z11591)
           imidazoleglycerol-phosphate dehydratase [Phytophthora
           parasitica]
           Length = 452
           
 Score =  212 bits (535), Expect = 1e-54
 Identities = 112/216 (51%), Positives = 141/216 (64%), Gaps = 24/216 (11%)

Query: 4   QKALVKRITNETKIQIAISLKGGPLAIEHSIFPEKEAEAVAEQATQSQVINVHTGIGFLD 63
           ++A + R+T ET I + +SL G   +                         V +GIGFLD
Sbjct: 260 REANISRVTKETSISVKLSLDGTGKS------------------------KVSSGIGFLD 295

Query: 64  HMIHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRGVKRFGSGFAP 123
           HM+ ALAKHS + L ++C GD  IDDHHTTEDC + LG+AF  ALG   G+ RFGS   P
Sbjct: 296 HMLTALAKHSRFDLELDCKGDTWIDDHHTTEDCALTLGEAFDVALGDRAGIARFGSACVP 355

Query: 124 LDEALSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRITLHVDCLRGK 183
           LDEALSRA+VD+S+R ++ + L L R  VG+LS EMI HF ESFA A+  TLHVD LRG+
Sbjct: 356 LDEALSRAIVDISSRAHSEINLQLVRPSVGELSSEMITHFFESFASAALXTLHVDVLRGR 415

Query: 184 NDHHRSESAFKALAVAIREATSPNGTNDVPSTKGVL 219
           NDHHR+E++FKALAVA+R A   + T  VPSTKGVL
Sbjct: 416 NDHHRAEASFKALAVALRTAVKHDATAGVPSTKGVL 451


>gi|123157|sp|P18787|HIS7_AZOBR IMIDAZOLEGLYCEROL-PHOSPHATE
           DEHYDRATASE (IGPD) >gi|77541|pir||JE0045
           imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) -
           Azospirillum brasilense >gi|38667|emb|CAA35478| (X17435)
           hisB [Azospirillum brasilense] >gi|38670|emb|CAA43515|
           (X61207) Imidazole glycerolphosphate  dehydratase
           [Azospirillum brasilense] >gi|227036|prf||1613413B hisB
           gene [Azospirillum brasilense]
           Length = 207
           
 Score =  178 bits (446), Expect = 4e-44
 Identities = 90/216 (41%), Positives = 133/216 (60%), Gaps = 26/216 (12%)

Query: 6   ALVKRITNETKIQIAISLKGGPLAIEHSIFPEKEAEAVAEQATQSQVINVHTGIGFLDHM 65
           A ++R T ET+I++A++L G                        + V +V TG+GFLDHM
Sbjct: 12  ASIERNTTETRIRVAVNLDG------------------------TGVYDVKTGVGFLDHM 47

Query: 66  IHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRGVKRFGSGFAPLD 125
           +  L++HS   L V   GD+HID HHTTE  GIA+GQA  +A+G  +G++R+G  + P+D
Sbjct: 48  LEQLSRHSLMDLSVAAEGDVHIDAHHTTEHSGIAIGQAVAKAVGDRKGIQRYGHAYVPMD 107

Query: 126 EALSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRITLHVDCLRGKND 185
           E L+R  +D SNRPY + ++   R+K+GD+  E+   + ++FA A+ +TLHV+CL G+N+
Sbjct: 108 ETLTRVALDFSNRPYLIWKVSFSRDKIGDMDTELFREWFQAFAMAAGVTLHVECLYGENN 167

Query: 186 HHRSESAFKALAVAIREA--TSPNGTNDVPSTKGVL 219
           HH  ES +KALA A+R      P   + VPSTKG L
Sbjct: 168 HHIVESCYKALARALRAGIEIDPRKRDAVPSTKGTL 203


>gi|2495230|sp|Q43072|HIS7_PEA IMIDAZOLEGLYCEROL-PHOSPHATE
           DEHYDRATASE (IGPD) >gi|1381086 (U49978)
           imidazoleglycerol-phosphate dehydratase [Pisum sativum]
           Length = 281
           
 Score =  162 bits (407), Expect = 1e-39
 Identities = 89/214 (41%), Positives = 120/214 (55%), Gaps = 26/214 (12%)

Query: 8   VKRITNETKIQIAISLKGGPLAIEHSIFPEKEAEAVAEQATQSQVINVHTGIGFLDHMIH 67
           VKR+T ET + + I+L G                        S V +  TGI FLDHM+ 
Sbjct: 89  VKRVTKETNVSVKINLDG------------------------SGVADSSTGIPFLDHMLD 124

Query: 68  ALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRGVKRFGSGFAPLDEA 127
            LA H  + + V+  GD+HIDDHHT ED  +A+G A  +ALG  +G+ RFG   APLDEA
Sbjct: 125 QLASHGLFDVHVKATGDVHIDDHHTNEDVALAIGTALLQALGDRKGINRFGDFSAPLDEA 184

Query: 128 LSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRITLHVDCLRGKNDHH 187
           L    +DLS RP+    L +  ++VG    +++ HFL+S    S +TLH+  L G+N HH
Sbjct: 185 LIHVSLDLSGRPHLSYNLDIPTQRVGTYDTQVVEHFLQSIVNTSGMTLHIRQLAGRNSHH 244

Query: 188 RSESAFKALAVAIREAT--SPNGTNDVPSTKGVL 219
             E+ FKA A A+R+AT   P     VPS+KGVL
Sbjct: 245 IIEATFKAFARALRQATEYDPRRRGSVPSSKGVL 278


>gi|2495226|sp|Q50504|HIS7_METTH PROBABLE
           IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE (IGPD)
           >gi|726053 (U19362) imidazoleglycerol-phosphate
           dehydrogenase [Methanobacterium thermoautotrophicum]
           Length = 194
           
 Score =  161 bits (404), Expect = 3e-39
 Identities = 77/166 (46%), Positives = 112/166 (67%), Gaps = 2/166 (1%)

Query: 54  NVHTGIGFLDHMIHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRG 113
           +V+TG+GFLDHM+ ++A+H    L VE  GDL +DDHHT ED  + LG+A +EALG   G
Sbjct: 31  SVNTGLGFLDHMLESVARHGLLDLEVEARGDLEVDDHHTVEDVALTLGEALREALGDKSG 90

Query: 114 VKRFGSGFAPLDEALSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRI 173
           ++R      P+D+AL+   +DLS RPY V+EL      +GD+  + I HF+ES A ++ +
Sbjct: 91  IRRMAHAMVPMDDALATVALDLSGRPYTVLELEFDDAVIGDVKSQNIGHFIESLAVSAAM 150

Query: 174 TLHVDCLRGKNDHHRSESAFKALAVAIREATSPNGTNDVPSTKGVL 219
            +H   +RG+NDHH++E+ FKALA+AIR+A       ++PSTKG L
Sbjct: 151 NIHAS-VRGRNDHHKAEALFKALALAIRDAVRVE-HGEIPSTKGKL 194


>gi|2622582 (AE000908) imidazoleglycerol-phosphate dehydratase
           [Methanobacterium thermoautotrophicum]
           Length = 177
           
 Score =  161 bits (404), Expect = 3e-39
 Identities = 77/166 (46%), Positives = 112/166 (67%), Gaps = 2/166 (1%)

Query: 54  NVHTGIGFLDHMIHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRG 113
           +V+TG+GFLDHM+ ++A+H    L VE  GDL +DDHHT ED  + LG+A +EALG   G
Sbjct: 14  SVNTGLGFLDHMLESVARHGLLDLEVEARGDLEVDDHHTVEDVALTLGEALREALGDKSG 73

Query: 114 VKRFGSGFAPLDEALSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRI 173
           ++R      P+D+AL+   +DLS RPY V+EL      +GD+  + I HF+ES A ++ +
Sbjct: 74  IRRMAHAMVPMDDALATVALDLSGRPYTVLELEFDDAVIGDVKSQNIGHFIESLAVSAAM 133

Query: 174 TLHVDCLRGKNDHHRSESAFKALAVAIREATSPNGTNDVPSTKGVL 219
            +H   +RG+NDHH++E+ FKALA+AIR+A       ++PSTKG L
Sbjct: 134 NIHAS-VRGRNDHHKAEALFKALALAIRDAVRVE-HGEIPSTKGKL 177


>gi|3982576 (AF023140) imidazoleglycerol phosphate dehydratase
           [Thlaspi goesingense]
           Length = 274
           
 Score =  158 bits (396), Expect = 3e-38
 Identities = 88/214 (41%), Positives = 116/214 (54%), Gaps = 26/214 (12%)

Query: 8   VKRITNETKIQIAISLKGGPLAIEHSIFPEKEAEAVAEQATQSQVINVHTGIGFLDHMIH 67
           VKR T ET + + I+L G  +A                        +  TGI FLDHM+ 
Sbjct: 82  VKRETKETNVSVKINLDGNGVA------------------------DSSTGIPFLDHMLD 117

Query: 68  ALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRGVKRFGSGFAPLDEA 127
            LA H  + + V   GD HIDDHHT ED  +A+G A  +ALG  +G+ RFG   APLDEA
Sbjct: 118 QLASHGLFDVHVRATGDTHIDDHHTNEDVALAIGTALLKALGERKGINRFGDFTAPLDEA 177

Query: 128 LSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRITLHVDCLRGKNDHH 187
           L    +DLS RPY    L +  ++VG    +++ HF +S    S +TLH+  L GKN HH
Sbjct: 178 LIHVSLDLSGRPYLGYSLEIPTQRVGTYDTQLVEHFFQSLVNTSGMTLHIRQLAGKNSHH 237

Query: 188 RSESAFKALAVAIREAT--SPNGTNDVPSTKGVL 219
             E+ FKA A A+R+AT   P     +PS+KGVL
Sbjct: 238 IIEATFKAFARALRQATESDPRRGGTIPSSKGVL 271


>gi|462273|sp|P34047|HIS7_ARATH IMIDAZOLEGLYCEROL-PHOSPHATE
           DEHYDRATASE (IGPD) >gi|437213 (U02689)
           imidazoleglycerolphosphate dehydratase [Arabidopsis
           thaliana]
           Length = 270
           
 Score =  158 bits (395), Expect = 3e-38
 Identities = 87/214 (40%), Positives = 117/214 (54%), Gaps = 26/214 (12%)

Query: 8   VKRITNETKIQIAISLKGGPLAIEHSIFPEKEAEAVAEQATQSQVINVHTGIGFLDHMIH 67
           VKR+T ET + + I+L G  +A   S                        GI FLDHM+ 
Sbjct: 78  VKRVTKETNVSVKINLDGTGVADSSS------------------------GIPFLDHMLD 113

Query: 68  ALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRGVKRFGSGFAPLDEA 127
            LA H  + + V   GD+HIDDHHT ED  +A+G A  +ALG  +G+ RFG   APLDEA
Sbjct: 114 QLASHGLFDVHVRATGDVHIDDHHTNEDIALAIGTALLKALGERKGINRFGDFTAPLDEA 173

Query: 128 LSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRITLHVDCLRGKNDHH 187
           L    +DLS RPY    L +  ++VG    +++ HF +S    S +TLH+  L G+N HH
Sbjct: 174 LIHVSLDLSGRPYLGYNLEIPTQRVGTYDTQLVEHFFQSLVNTSGMTLHIRQLAGENSHH 233

Query: 188 RSESAFKALAVAIREA--TSPNGTNDVPSTKGVL 219
             E+ FKA A A+R+A  T P     +PS+KGVL
Sbjct: 234 IIEATFKAFARALRQATETDPRRGGTIPSSKGVL 267


>gi|2398791|emb|CAA60712| (X87256) imidazoleglycerol-phosphate
           dehydratase [Rhodobacter sphaeroides]
           Length = 195
           
 Score =  157 bits (394), Expect = 4e-38
 Identities = 87/218 (39%), Positives = 119/218 (53%), Gaps = 26/218 (11%)

Query: 4   QKALVKRITNETKIQIAISLKGGPLAIEHSIFPEKEAEAVAEQATQSQVINVHTGIGFLD 63
           +KA + R T ET I + + L G                        +   ++ TG+GF D
Sbjct: 2   RKAEISRKTAETDISVTVDLDG------------------------TGRYDIRTGVGFFD 37

Query: 64  HMIHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRGVKRFGSGFAP 123
           HM+            + C GDLHIDDHHT EDCGIALGQA   ALG    ++R+GS    
Sbjct: 38  HMMDQARPARADRHPLRCEGDLHIDDHHTVEDCGIALGQALTRALGDKARIRRYGSFHLA 97

Query: 124 LDEALSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRITLHVDCLRGK 183
           +D+AL RA +DLS RP+ V  L    EK+G    E++  F ++ A    ITLHVD + G 
Sbjct: 98  MDDALVRAALDLSGRPFLVWNLPFPTEKIGSFDTELVREFFQALATHGGITLHVDLIHGV 157

Query: 184 NDHHRSESAFKALAVAIREATSPN--GTNDVPSTKGVL 219
           N HH +E+AFKA+A ++REA  P+    + +PSTKG+L
Sbjct: 158 NSHHIAEAAFKAVARSLREAVEPDPRRADAIPSTKGML 195


>gi|2244848|emb|CAB10270| (Z97337) imidazoleglycerol-phosphate
           dehydratase [Arabidopsis thaliana]
           Length = 259
           
 Score =  157 bits (392), Expect = 8e-38
 Identities = 88/214 (41%), Positives = 115/214 (53%), Gaps = 26/214 (12%)

Query: 8   VKRITNETKIQIAISLKGGPLAIEHSIFPEKEAEAVAEQATQSQVINVHTGIGFLDHMIH 67
           VKR T ET + + I+L G                          V +  TGI FLDHM+ 
Sbjct: 67  VKRETKETNVSVKINLDG------------------------HGVSDSSTGIPFLDHMLD 102

Query: 68  ALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRGVKRFGSGFAPLDEA 127
            LA H  + + V   GD HIDDHHT ED  +A+G A  +ALG  +G+ RFG   APLDEA
Sbjct: 103 QLASHGLFDVHVRATGDTHIDDHHTNEDVALAIGTALLKALGERKGINRFGDFTAPLDEA 162

Query: 128 LSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRITLHVDCLRGKNDHH 187
           L    +DLS RPY    L +  ++VG    +++ HF +S    S +TLH+  L GKN HH
Sbjct: 163 LIHVSLDLSGRPYLGYNLEIPTQRVGTYDTQLVEHFFQSLVNTSGMTLHIRQLAGKNSHH 222

Query: 188 RSESAFKALAVAIREAT--SPNGTNDVPSTKGVL 219
             E+ FKA A A+R+AT   P     +PS+KGVL
Sbjct: 223 IIEATFKAFARALRQATESDPRRGGTIPSSKGVL 256


>gi|123158|sp|P06987|HIS7_ECOLI IMIDAZOLEGLYCEROL-PHOSPHATE
           DEHYDRATASE (IGPD) / HISTIDINOL-PHOSPHATASE
           >gi|68327|pir||DWECHB hisB bifunctional enzyme -
           Escherichia coli >gi|41696|emb|CAA27151| (X03416) hisB
           protein [Escherichia coli] >gi|41711|emb|CAA31814|
           (X13462) hisB ORF (AA 1-355) [Escherichia coli]
           >gi|1736700|gnl|PID|d1016577 (D90840) HisB bifunctional
           enzyme [Escherichia coli]
           Length = 355
           
 Score =  156 bits (391), Expect = 1e-37
 Identities = 79/165 (47%), Positives = 108/165 (64%), Gaps = 3/165 (1%)

Query: 55  VHTGIGFLDHMIHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRGV 114
           ++TG+GF DHM+  +A H G+ + +   GDL+IDDHHT ED G+ALG+A K ALG  RG+
Sbjct: 194 INTGVGFFDHMLDQIATHGGFRMEINVKGDLYIDDHHTVEDTGLALGEALKIALGDKRGI 253

Query: 115 KRFGSGFAPLDEALSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRIT 174
            RFG    P+DE L+R  +D+S RP+   +     ++VGDLS EMI HF  S +    +T
Sbjct: 254 CRFGF-VLPMDECLARCALDISGRPHLEYKAEFTYQRVGDLSTEMIEHFFRSLSYTMGVT 312

Query: 175 LHVDCLRGKNDHHRSESAFKALAVAIREATSPNGTNDVPSTKGVL 219
           LH+   +GKNDHHR ES FKA    +R+A    G + +PS+KGVL
Sbjct: 313 LHLK-TKGKNDHHRVESLFKAFGRTLRQAIRVEG-DTLPSSKGVL 355


>gi|1736709|gnl|PID|d1016585 (D90841) HisB bifunctional enzyme
           [Escherichia coli]
           Length = 277
           
 Score =  156 bits (391), Expect = 1e-37
 Identities = 79/165 (47%), Positives = 108/165 (64%), Gaps = 3/165 (1%)

Query: 55  VHTGIGFLDHMIHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRGV 114
           ++TG+GF DHM+  +A H G+ + +   GDL+IDDHHT ED G+ALG+A K ALG  RG+
Sbjct: 116 INTGVGFFDHMLDQIATHGGFRMEINVKGDLYIDDHHTVEDTGLALGEALKIALGDKRGI 175

Query: 115 KRFGSGFAPLDEALSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRIT 174
            RFG    P+DE L+R  +D+S RP+   +     ++VGDLS EMI HF  S +    +T
Sbjct: 176 CRFGF-VLPMDECLARCALDISGRPHLEYKAEFTYQRVGDLSTEMIEHFFRSLSYTMGVT 234

Query: 175 LHVDCLRGKNDHHRSESAFKALAVAIREATSPNGTNDVPSTKGVL 219
           LH+   +GKNDHHR ES FKA    +R+A    G + +PS+KGVL
Sbjct: 235 LHLK-TKGKNDHHRVESLFKAFGRTLRQAIRVEG-DTLPSSKGVL 277


>gi|1788333 (AE000293) imidazoleglycerolphosphate dehydratase and
           histidinol-phosphate phosphatase [Escherichia coli]
           Length = 356
           
 Score =  156 bits (391), Expect = 1e-37
 Identities = 79/165 (47%), Positives = 108/165 (64%), Gaps = 3/165 (1%)

Query: 55  VHTGIGFLDHMIHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRGV 114
           ++TG+GF DHM+  +A H G+ + +   GDL+IDDHHT ED G+ALG+A K ALG  RG+
Sbjct: 195 INTGVGFFDHMLDQIATHGGFRMEINVKGDLYIDDHHTVEDTGLALGEALKIALGDKRGI 254

Query: 115 KRFGSGFAPLDEALSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRIT 174
            RFG    P+DE L+R  +D+S RP+   +     ++VGDLS EMI HF  S +    +T
Sbjct: 255 CRFGF-VLPMDECLARCALDISGRPHLEYKAEFTYQRVGDLSTEMIEHFFRSLSYTMGVT 313

Query: 175 LHVDCLRGKNDHHRSESAFKALAVAIREATSPNGTNDVPSTKGVL 219
           LH+   +GKNDHHR ES FKA    +R+A    G + +PS+KGVL
Sbjct: 314 LHLK-TKGKNDHHRVESLFKAFGRTLRQAIRVEG-DTLPSSKGVL 356


>gi|2618867 (AF017113) imidazoleglycerol-phosphate dehydratase
           [Bacillus subtilis] >gi|2636003|emb|CAB15495| (Z99121)
           imidazoleglycerol-phosphate dehydratase [Bacillus
           subtilis]
           Length = 194
           
 Score =  156 bits (391), Expect = 1e-37
 Identities = 88/217 (40%), Positives = 120/217 (54%), Gaps = 25/217 (11%)

Query: 4   QKALVKRITNETKIQIAISLKGGPLAIEHSIFPEKEAEAVAEQATQSQVINVHTGIGFLD 63
           +KA   R TNET I++A ++ GG  A                        ++ T + F+ 
Sbjct: 2   RKAERVRKTNETDIELAFTIDGGGQA------------------------DIKTDVPFMT 37

Query: 64  HMIHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRGVKRFGSGFAP 123
           HM+    KH  + L +   GD+ IDDHHTTED GI LGQA  EALG  +G+KR+GS F P
Sbjct: 38  HMLDLFTKHGQFDLSINAKGDVDIDDHHTTEDIGICLGQALLEALGDKKGIKRYGSAFVP 97

Query: 124 LDEALSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRITLHVDCLRGK 183
           +DEAL++ V+DLSNRP+  +       KVG    E++  FL   A  +R+ LHV    G 
Sbjct: 98  MDEALAQVVIDLSNRPHLEMRADFPAAKVGTFDTELVHEFLWKLALEARMNLHVIVHYGT 157

Query: 184 NDHHRSESAFKALAVAIREATSPN-GTNDVPSTKGVL 219
           N HH  E+ FKAL  A+ EAT+ +     +PSTKG+L
Sbjct: 158 NTHHMIEAVFKALGRALDEATTIDPRVKGIPSTKGML 194


>gi|551331 (U02690) imidazoleglycerolphosphate dehydratase [Triticum
           aestivum]
           Length = 198
           
 Score =  155 bits (388), Expect = 2e-37
 Identities = 85/214 (39%), Positives = 117/214 (53%), Gaps = 26/214 (12%)

Query: 8   VKRITNETKIQIAISLKGGPLAIEHSIFPEKEAEAVAEQATQSQVINVHTGIGFLDHMIH 67
           VKR+T ET + + I+L G                        + V N  TGI FLDHM+ 
Sbjct: 6   VKRVTKETNVHVKINLDG------------------------TGVANSSTGIPFLDHMLD 41

Query: 68  ALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRGVKRFGSGFAPLDEA 127
            LA H  + + V+  GD HIDDHH+ ED  +A+G A  +ALG  +G+ RFG   APLDEA
Sbjct: 42  QLASHGLFDVYVKATGDTHIDDHHSNEDIALAIGTALLQALGDRKGINRFGHFTAPLDEA 101

Query: 128 LSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRITLHVDCLRGKNDHH 187
               ++DLS RP+    L +  E+VG    +++ HF +S    S +TLH+  L G N HH
Sbjct: 102 AVEVILDLSGRPHLSCGLSIPTERVGTYDTQLVEHFFQSLVNTSGMTLHIRQLAGNNSHH 161

Query: 188 RSESAFKALAVAIREATSPN--GTNDVPSTKGVL 219
             E+ FKA A A+R+AT  +      +PS+KGVL
Sbjct: 162 IIEATFKAFARALRQATEYDLRRQGTMPSSKGVL 195


>gi|462275|sp|P34048|HIS7_WHEAT IMIDAZOLEGLYCEROL-PHOSPHATE
           DEHYDRATASE (IGPD)
           Length = 195
           
 Score =  155 bits (388), Expect = 2e-37
 Identities = 85/214 (39%), Positives = 117/214 (53%), Gaps = 26/214 (12%)

Query: 8   VKRITNETKIQIAISLKGGPLAIEHSIFPEKEAEAVAEQATQSQVINVHTGIGFLDHMIH 67
           VKR+T ET + + I+L G                        + V N  TGI FLDHM+ 
Sbjct: 3   VKRVTKETNVHVKINLDG------------------------TGVANSSTGIPFLDHMLD 38

Query: 68  ALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRGVKRFGSGFAPLDEA 127
            LA H  + + V+  GD HIDDHH+ ED  +A+G A  +ALG  +G+ RFG   APLDEA
Sbjct: 39  QLASHGLFDVYVKATGDTHIDDHHSNEDIALAIGTALLQALGDRKGINRFGHFTAPLDEA 98

Query: 128 LSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRITLHVDCLRGKNDHH 187
               ++DLS RP+    L +  E+VG    +++ HF +S    S +TLH+  L G N HH
Sbjct: 99  AVEVILDLSGRPHLSCGLSIPTERVGTYDTQLVEHFFQSLVNTSGMTLHIRQLAGNNSHH 158

Query: 188 RSESAFKALAVAIREATSPN--GTNDVPSTKGVL 219
             E+ FKA A A+R+AT  +      +PS+KGVL
Sbjct: 159 IIEATFKAFARALRQATEYDLRRQGTMPSSKGVL 192


>gi|1170286|sp|P44327|HIS7_HAEIN IMIDAZOLEGLYCEROL-PHOSPHATE
           DEHYDRATASE (IGPD) / HISTIDINOL-PHOSPHATASE
           >gi|1074923|pir||F64070 imidazoleglycerol-phosphate
           dehydratase (hisB) homolog - Haemophilus influenzae
           (strain Rd KW20) >gi|1573450 (U32730)
           imidazoleglycerol-phosphate dehydratase /
           histidinol-phosphatase (hisB) [Haemophilus influenzae
           Rd]
           Length = 362
           
 Score =  155 bits (387), Expect = 3e-37
 Identities = 78/171 (45%), Positives = 110/171 (63%), Gaps = 3/171 (1%)

Query: 49  QSQVINVHTGIGFLDHMIHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEAL 108
           ++ V  + TG+GF DHM+  +A H G+ + V+C GDL ID+HHT ED  +ALGQA K+A+
Sbjct: 195 EAGVNEIKTGVGFFDHMLDQIATHGGFRMNVQCKGDLWIDEHHTVEDTALALGQALKQAV 254

Query: 109 GAVRGVKRFGSGFAPLDEALSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFA 168
           G  RG+ RFG    P+DE  +   +DLS RP+       +R+KVGD S E+  HF +S A
Sbjct: 255 GDKRGIARFGF-VLPMDECKAECALDLSGRPWIKFNACFKRDKVGDFSTELTEHFFQSLA 313

Query: 169 EASRITLHVDCLRGKNDHHRSESAFKALAVAIREATSPNGTNDVPSTKGVL 219
            +   TLH++ + G NDHH+ ES FKA    +R+A    G N++PS+KGVL
Sbjct: 314 FSMLATLHLN-VTGNNDHHKIESLFKAFGRTLRQAIRIEG-NEMPSSKGVL 362


>gi|1346293|sp|P48054|HIS7_SYNY3 IMIDAZOLEGLYCEROL-PHOSPHATE
           DEHYDRATASE (IGPD) >gi|1001734|gnl|PID|d1011222 (D64004)
           imidazoleglycerol-phosphate dehydratase [Synechocystis
           sp.]
           Length = 210
           
 Score =  155 bits (387), Expect = 3e-37
 Identities = 87/216 (40%), Positives = 117/216 (53%), Gaps = 26/216 (12%)

Query: 6   ALVKRITNETKIQIAISLKGGPLAIEHSIFPEKEAEAVAEQATQSQVINVHTGIGFLDHM 65
           A V R+T ET ++++++L G  L                         +V TG+ FLDHM
Sbjct: 19  AAVHRVTKETDVRVSLNLMGSGLC------------------------HVATGVPFLDHM 54

Query: 66  IHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRGVKRFGSGFAPLD 125
           +H +A H    L V   GD+ IDDHHT ED GI LGQA  EALG  RG+ RFG   APLD
Sbjct: 55  LHQIASHGLIDLEVNATGDIEIDDHHTNEDVGITLGQALAEALGDRRGINRFGHFIAPLD 114

Query: 126 EALSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRITLHVDCLRGKND 185
           EAL +  +D S RP+    L +  E+VG    +++  F  +    S++TLH+  L G N 
Sbjct: 115 EALVQVTLDFSGRPHLSYGLQIPTERVGTYDTQLVREFFVAVVNHSQMTLHIRQLDGINS 174

Query: 186 HHRSESAFKALAVAIREA--TSPNGTNDVPSTKGVL 219
           HH  E+ FKA A A+R A    P   + +PS+KGVL
Sbjct: 175 HHIIEATFKAFARAMRMAIEVDPRRADTIPSSKGVL 210


>gi|4038317 (AF067228) imidazoleglycerolphosphate dehydratase/
           histidinolphosphate phosphatase [Buchnera aphidicola]
           Length = 355
           
 Score =  152 bits (379), Expect = 3e-36
 Identities = 75/165 (45%), Positives = 107/165 (64%), Gaps = 3/165 (1%)

Query: 55  VHTGIGFLDHMIHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRGV 114
           + TGI F DHM+  L+ HSG S+ +   GDL IDDHHT ED GI LG+A  +AL    G+
Sbjct: 194 IQTGINFFDHMLEQLSIHSGISMYILAKGDLQIDDHHTIEDTGIVLGEALSQALNNKNGL 253

Query: 115 KRFGSGFAPLDEALSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRIT 174
            R+G    P+DE+ ++ ++DLSNRPY       + + VGD++ +M+ HF  S   + +IT
Sbjct: 254 SRYGF-VLPMDESQAKCIIDLSNRPYLSFNAHFKHKMVGDMNTDMVEHFFYSLCCSMKIT 312

Query: 175 LHVDCLRGKNDHHRSESAFKALAVAIREATSPNGTNDVPSTKGVL 219
           LH+D ++GKNDHH  ES FKA   A+R+A    G N +P++KG+L
Sbjct: 313 LHID-VKGKNDHHCIESLFKAFGRALRKAVKIEG-NTLPTSKGIL 355


>gi|2982780 (AE000670) imidazoleglycerolphosphate dehydratase
           [Aquifex aeolicus]
           Length = 192
           
 Score =  151 bits (378), Expect = 3e-36
 Identities = 87/216 (40%), Positives = 121/216 (55%), Gaps = 25/216 (11%)

Query: 4   QKALVKRITNETKIQIAISLKGGPLAIEHSIFPEKEAEAVAEQATQSQVINVHTGIGFLD 63
           ++A V R T ETKI++ I+L G                        S    V+T +GFL 
Sbjct: 2   REAEVFRETRETKIKLYINLDG------------------------SGNYEVNTPVGFLT 37

Query: 64  HMIHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRGVKRFGSGFAP 123
           HM+ + AKH  + L VE  GD+H+  HHT EDCGI LGQA  +ALG  +G++R+G    P
Sbjct: 38  HMLESFAKHGRFDLKVEAEGDVHVSHHHTVEDCGIVLGQAVLKALGDKKGIRRYGYSIIP 97

Query: 124 LDEALSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRITLHVDCLRGK 183
           +DEAL  + +D+S RP    E    R K+ +   E+I  F + FA  SR TLH+  L GK
Sbjct: 98  MDEALVLSSIDISGRPLFFYEDKDLRGKITEFDFELIWEFFKGFALESRSTLHIKVLDGK 157

Query: 184 NDHHRSESAFKALAVAIREATSPNGTNDVPSTKGVL 219
             HH +E+ FK+ A+ ++EA    G+  VPSTKGV+
Sbjct: 158 ILHHVAEACFKSFAITLKEAVKVEGSG-VPSTKGVI 192


>gi|462272|sp|Q05068|HIS7_ANASP IMIDAZOLEGLYCEROL-PHOSPHATE
           DEHYDRATASE (IGPD) >gi|142011 (L10036) unknown [Anabaena
           PCC7120]
           Length = 209
           
 Score =  148 bits (371), Expect = 2e-35
 Identities = 85/216 (39%), Positives = 114/216 (52%), Gaps = 26/216 (12%)

Query: 6   ALVKRITNETKIQIAISLKGGPLAIEHSIFPEKEAEAVAEQATQSQVINVHTGIGFLDHM 65
           A V RIT ET +Q+ ++L G                        + +    TGI FLDHM
Sbjct: 18  ASVHRITGETNVQVTVNLDG------------------------TGICKAATGIPFLDHM 53

Query: 66  IHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRGVKRFGSGFAPLD 125
           +H ++ H    L V+  GD  IDDHHT ED GI LGQA  +ALG  +G+ RFG+  APLD
Sbjct: 54  LHQISSHGLIDLDVQAKGDWEIDDHHTNEDVGITLGQALAKALGDRKGIVRFGNFLAPLD 113

Query: 126 EALSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRITLHVDCLRGKND 185
           EAL +  +D S RP+    L +  E+VG    +++  F  +    S++TLH+  L G N 
Sbjct: 114 EALVQVALDFSGRPHLSYGLQIPTERVGTYDTQLVREFFVALVNHSQMTLHIRQLDGINS 173

Query: 186 HHRSESAFKALAVAIREA--TSPNGTNDVPSTKGVL 219
           HH  E+ FKA A A R A    P     +PS+KGVL
Sbjct: 174 HHIIEATFKAFARAARMAIEVDPRRAGTIPSSKGVL 209


>gi|123161|sp|P16247|HIS7_STRCO IMIDAZOLEGLYCEROL-PHOSPHATE
           DEHYDRATASE (IGPD) >gi|80735|pir||JQ0638
           imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) -
           Streptomyces coelicolor >gi|153298 (M31628)
           imidazoleglycerol-phosphate dehydratase (hisB) (EC
           4.2.1.19) [Streptomyces coelicolor]
           Length = 197
           
 Score =  146 bits (365), Expect = 1e-34
 Identities = 86/215 (40%), Positives = 114/215 (53%), Gaps = 27/215 (12%)

Query: 8   VKRITNETKIQIAISLKGGPLAIEHSIFPEKEAEAVAEQATQSQVINVHTGIGFLDHMIH 67
           V+R T ET + + I L G                        +   ++ TG+GF DHM+ 
Sbjct: 7   VERTTKETSVLVEIDLDG------------------------TGKTDIATGVGFYDHMLD 42

Query: 68  ALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRGVKRFGSGFAPLDEA 127
            L +H  + L V+  GDLHID HHT ED  +ALG AF++ALG   G+ RFG+   PLDE+
Sbjct: 43  QLGRHGLFDLTVKTDGDLHIDSHHTIEDTALALGAAFRQALGDKVGIYRFGNCTVPLDES 102

Query: 128 LSRAVVDLSNRPYAV-VELGLQREKVGDLSCEMIPHFLESFAEASRITLHVDCLRGKNDH 186
           L++  VDLS RPY V  E       +G+    M  H LESF   +++ LHV    G+N H
Sbjct: 103 LAQVTVDLSGRPYLVHTEPENMAPMIGEYDVTMTRHILESFVAQAQVALHVHVPYGRNAH 162

Query: 187 HRSESAFKALAVAIREAT--SPNGTNDVPSTKGVL 219
           H  E  FKALA A+R A+   P     +PSTKG L
Sbjct: 163 HIVECQFKALARALRYASERDPRAAGILPSTKGAL 197


>gi|123160|sp|P10368|HIS7_SALTY IMIDAZOLEGLYCEROL-PHOSPHATE
           DEHYDRATASE (IGPD) / HISTIDINOL-PHOSPHATASE
           >gi|68328|pir||DWEBHB hisB bifunctional enzyme -
           Salmonella typhimurium
           Length = 354
           
 Score =  142 bits (354), Expect = 2e-33
 Identities = 76/165 (46%), Positives = 106/165 (64%), Gaps = 4/165 (2%)

Query: 55  VHTGIGFLDHMIHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRGV 114
           ++TG+GF DHM+  +A H G+ + +   GDL+IDDHHT ED G+AL +A K AL   RG+
Sbjct: 194 INTGVGFFDHMLDQIATHGGFRMEITVKGDLYIDDHHTVEDTGLALREALKLALRDKRGI 253

Query: 115 KRFGSGFAPLDEALSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRIT 174
            RFG    P+DE L+ A +D+S RP+   +     ++VG+LS EMI HF  S +    +T
Sbjct: 254 CRFGF-VLPMDECLACA-LDISGRPHLEYKAEFTYQRVGNLSTEMIEHFFRSLSYTMGVT 311

Query: 175 LHVDCLRGKNDHHRSESAFKALAVAIREATSPNGTNDVPSTKGVL 219
           LH+   +GKNDHHR ES FKA    +R+A    G + +PS+KGVL
Sbjct: 312 LHLK-TKGKNDHHRVESLFKAFGRTVRQAIRVEG-DTLPSSKGVL 354


>gi|1333842|emb|CAA31825| (X13464) hisB ORF (AA 1-353) [Salmonella
           typhimurium]
           Length = 353
           
 Score =  142 bits (354), Expect = 2e-33
 Identities = 76/165 (46%), Positives = 106/165 (64%), Gaps = 4/165 (2%)

Query: 55  VHTGIGFLDHMIHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRGV 114
           ++TG+GF DHM+  +A H G+ + +   GDL+IDDHHT ED G+AL +A K AL   RG+
Sbjct: 193 INTGVGFFDHMLDQIATHGGFRMEITVKGDLYIDDHHTVEDTGLALREALKLALRDKRGI 252

Query: 115 KRFGSGFAPLDEALSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRIT 174
            RFG    P+DE L+ A +D+S RP+   +     ++VG+LS EMI HF  S +    +T
Sbjct: 253 CRFGF-VLPMDECLACA-LDISGRPHLEYKAEFTYQRVGNLSTEMIEHFFRSLSYTMGVT 310

Query: 175 LHVDCLRGKNDHHRSESAFKALAVAIREATSPNGTNDVPSTKGVL 219
           LH+   +GKNDHHR ES FKA    +R+A    G + +PS+KGVL
Sbjct: 311 LHLK-TKGKNDHHRVESLFKAFGRTVRQAIRVEG-DTLPSSKGVL 353


>gi|2495224|sp|O06590|HIS7_MYCTU IMIDAZOLEGLYCEROL-PHOSPHATE
           DEHYDRATASE (IGPD) >gi|2117236|emb|CAB09093| (Z95586)
           hisB [Mycobacterium tuberculosis]
           Length = 210
           
 Score =  140 bits (349), Expect = 8e-33
 Identities = 76/175 (43%), Positives = 103/175 (58%), Gaps = 8/175 (4%)

Query: 53  INVHTGIGFLDHMIHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVR 112
           + V TG+ F DHM+ AL  H+ + L V   GD+ I+ HHT ED  IALG A  +ALG  R
Sbjct: 36  VAVDTGVPFYDHMLTALGSHASFDLTVRATGDVEIEAHHTIEDTAIALGTALGQALGDKR 95

Query: 113 GVKRFGSGFAPLDEALSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIP-------HFLE 165
           G++RFG  F P+DE L+ A VDLS RPY V        +   ++   +P       H  E
Sbjct: 96  GIRRFGDAFIPMDETLAHAAVDLSGRPYCVHTGEPDHLQHTTIAGSSVPYHTVINRHVFE 155

Query: 166 SFAEASRITLHVDCLRGKNDHHRSESAFKALAVAIREATSPN-GTNDVPSTKGVL 219
           S A  +RI LHV  L G++ HH +E+ +KA+A A+R+A  P+   + VPSTKG L
Sbjct: 156 SLAANARIALHVRVLYGRDPHHITEAQYKAVARALRQAVEPDPRVSGVPSTKGAL 210


>gi|3334215|sp|O33773|HIS7_SULSO PROBABLE
           IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE (IGPD)
           >gi|2253622 (U82227) imidazoleglycerol-phosphate
           dehydratase [Sulfolobus solfataricus]
           Length = 193
           
 Score =  140 bits (349), Expect = 8e-33
 Identities = 83/216 (38%), Positives = 117/216 (53%), Gaps = 25/216 (11%)

Query: 4   QKALVKRITNETKIQIAISLKGGPLAIEHSIFPEKEAEAVAEQATQSQVINVHTGIGFLD 63
           + A + R T ETKI++ + +             +++ E           + V T I F +
Sbjct: 3   RSANITRETKETKIEVLLDI-------------DRKGE-----------VKVSTPIPFFN 38

Query: 64  HMIHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRGVKRFGSGFAP 123
           HM+  L  +   + IV     L  DDHH  ED  I LG A K ALG  RG+KRF     P
Sbjct: 39  HMLITLLTYMNSTAIVSATDKLPYDDHHIVEDVAITLGLAIKTALGDKRGIKRFSHQIIP 98

Query: 124 LDEALSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRITLHVDCLRGK 183
           +D+AL    +D+SNR  A V L L+R ++G L+ E +PHF +SFA  S ITLH+  L G 
Sbjct: 99  MDDALVLVSLDISNRGMAFVNLNLKRSEIGGLATENVPHFFQSFAYNSGITLHISQLSGY 158

Query: 184 NDHHRSESAFKALAVAIREATSPNGTNDVPSTKGVL 219
           N HH  E++FKAL +A+ EAT     N++ STKG++
Sbjct: 159 NTHHIIEASFKALGLALYEATR-IVDNEIRSTKGII 193


>gi|2495225|sp|Q58109|HIS7_METJA PROBABLE
           IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE (IGPD)
           >gi|2129077|pir||B64387 imidazoleglycerol-phosphate
           dehydratase (EC 4.2.1.19) - Methanococcus jannaschii
           >gi|1591413 (U67516) imidazoleglycerol-phosphate
           dehydrogenase/histidinol-phosphatase (hisB)
           [Methanococcus jannaschii]
           Length = 197
           
 Score =  136 bits (338), Expect = 2e-31
 Identities = 73/163 (44%), Positives = 97/163 (58%), Gaps = 3/163 (1%)

Query: 55  VHTGIGFLDHMIHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEALGAVRGV 114
           + TGI F DH++ + AKH  + LIV+  GDL IDDHHT ED GI LG A  +     R +
Sbjct: 34  IDTGIPFFDHLLASFAKHGCFDLIVKARGDLEIDDHHTVEDVGICLGLALNQI--EKRNI 91

Query: 115 KRFGSGFAPLDEALSRAVVDLSNRPYAVVELGLQREKVGDLSCEMIPHFLESFAEASRIT 174
            RFG    P+D+A +   +DLS R Y V     +RE VGDL+ E I HF ES A    + 
Sbjct: 92  FRFGWAIIPMDDARATVAIDLSGRSYCVGNYEPKREFVGDLATENINHFFESVASYGMLN 151

Query: 175 LHVDCLRGKNDHHRSESAFKALAVAIREATSPNGTNDVPSTKG 217
           +H + + GKN+HH++E+ FKA  VA+  AT  +    V STKG
Sbjct: 152 IHYEVI-GKNEHHKAEALFKAFGVALDLATKIDERKGVISTKG 193


>gi|399896|sp|Q02134|HIS7_LACLA IMIDAZOLEGLYCEROL-PHOSPHATE
           DEHYDRATASE (IGPD) >gi|478210|pir||G45734 HisB -
           Lactococcus lactis subsp. lactis >gi|2565143 (U92974)
           HisB [Lactococcus lactis]
           Length = 200
           
 Score =  122 bits (304), Expect = 2e-27
 Identities = 79/218 (36%), Positives = 114/218 (52%), Gaps = 30/218 (13%)

Query: 8   VKRITNETKIQIAISLKGGPLAIEHSIFPEKEAEAVAEQATQSQVINVHTGIGFLDHMIH 67
           + R T ET+I+++I+L G   A                        ++ TGIGFLDHM+ 
Sbjct: 7   ITRNTKETQIELSINLDGTGQA------------------------DISTGIGFLDHMLT 42

Query: 68  ALAKHSGWSLIVECIGD---LHIDDHHTTEDCGIALGQAFKEALGAVRGVKRFGSGFAPL 124
            L  HS + L +   GD   + +D HH  ED  IALG+   E LG   G++R+GS   P+
Sbjct: 43  LLTFHSDFDLKIIGHGDHETVGMDPHHLIEDVAIALGKCISEDLGNKLGIRRYGSFTIPM 102

Query: 125 DEALSRAVVDLSNRPYAVVELGLQ-REKVGDLSCEMIPHFLESFAEASRITLHVDCLRGK 183
           DEAL    +D+S RPY V    L   +K+G    EM   F  + A  + ITLH++   G+
Sbjct: 103 DEALVTCDLDISGRPYLVFHADLSGNQKLGGYDTEMTEEFFRALAFNAGITLHLNEHYGQ 162

Query: 184 NDHHRSESAFKALAVAIREATS--PNGTNDVPSTKGVL 219
           N HH  E  FK+ A A+++A S   +   ++PS+KGVL
Sbjct: 163 NTHHIIEGMFKSTARALKQAVSIDESKVGEIPSSKGVL 200


>gi|2649620 (AE001036) imidazoleglycerol-phosphate
           dehydrogenase/histidinol-phosphatase (hisB)
           [Archaeoglobus fulgidus]
           Length = 178
           
 Score =  110 bits (272), Expect = 9e-24
 Identities = 67/182 (36%), Positives = 107/182 (57%), Gaps = 10/182 (5%)

Query: 38  KEAEAVAEQATQSQVINVHTGIGFLDHMIHALAKHSGWSLIVECIGDLHIDDHHTTEDCG 97
           ++ E    +    + + V TGI FLDHM+  L++HSG  L V+  GDL   +HH  ED  
Sbjct: 6   RKTEETEVEVVLGEELKVDTGIAFLDHMLKTLSRHSGIKLRVKAKGDL---EHHVIEDVA 62

Query: 98  IALGQAFKEALGAVRGVKRFGSGFAPLDEALSRAVVDLSNRPYAVVELGLQREKVGDLSC 157
           IALG+A   A    +G++RFG    P+D+A++   +D S R   VVE G   +  G++  
Sbjct: 63  IALGKAL--AGVDKKGLERFGDAIVPMDDAVAICGLDFSGRGVLVVE-GTFGD--GEMRE 117

Query: 158 EMIPHFLESFAEASRITLHVDCLRGKNDHHRSESAFKALAVAIREATSPNGTNDVPSTKG 217
           E   HFL++    + + +++  ++G N HH+ E+A KA+A+++++A + NG ND  S KG
Sbjct: 118 EDFLHFLDTLCRNAGLNVYLS-VKGSNSHHKMEAAVKAVAISLKKALTKNG-NDYRSAKG 175

Query: 218 VL 219
           VL
Sbjct: 176 VL 177


>gi|1197052 (J01330) imidazoleglycerolphosphate dehydratase
          [Saccharomyces cerevisiae]
          Length = 32
          
 Score = 64.8 bits (155), Expect = 5e-10
 Identities = 32/32 (100%), Positives = 32/32 (100%)

Query: 1  MTEQKALVKRITNETKIQIAISLKGGPLAIEH 32
          MTEQKALVKRITNETKIQIAISLKGGPLAIEH
Sbjct: 1  MTEQKALVKRITNETKIQIAISLKGGPLAIEH 32


  Database: nr
    Posted date:  Mar 13, 1999  7:20 PM
  Number of letters in database: 110,384,460
  Number of sequences in database:  361,503
  
Lambda     K      H
   0.318    0.134    0.384 

Gapped
Lambda     K      H
   0.270   0.0470    0.230 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44228550
Number of Sequences: 361503
Number of extensions: 1636266
Number of successful extensions: 3478
Number of sequences better than 1.0e-03: 42
Number of HSP's better than  0.0 without gapping: 41
Number of HSP's successfully gapped in prelim test: 1
Number of HSP's that attempted gapping in prelim test: 3377
Number of HSP's gapped (non-prelim): 43
length of query: 220
length of database: 110384460
effective HSP length: 55
effective length of query: 165
effective length of database: 90501795
effective search space: 14932796175
effective search space used: 14932796175
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 102 (44.1 bits)