From: Rich Murray [rmforall@att.net]
Sent: Monday, August 05, 2002 5:16 AM
To: fdadockets@oc.fda.gov
Subject: RTM: FDA (Section E) Wilson: CIIN info: formaldehyde toxicity
7.11.99 8.5.2 rmforall

RTM: FDA (Section E) Wilson: CIIN: formaldehyde toxicity 7.11.99 8.5.2
rmforall

http://groups.yahoo.com/group/aspartameNM/message/863
RTM: FDA (Section E) Wilson:
CIIN info: formaldehyde toxicity 7.11.99 8.5.2 rmforall

http://www.ciin.org/     chemicalinjury@ciin.org.
Chemical Injury Information Network
P.O.Box 301  White Sulphur Springs, MT 59645
406.547.2255   fax 2455

Chemical Exposure and Human Health; Cynthia Wilson, covers 314
chemicals in an easy-to read format. $55.00 US plus $2.00 shipping to
McFarland and Company Ltd.; P.O. Box 611; Jefferson NC 28640,
800-253-2187.

The Human Consequences of the Chemical Problem by Cindy
Duehring and Cynthia Wilson, $7.20, TT Publishing, PO Box T,
White Sulphur Springs MT 59645

Formaldehyde   (From "Chemical Exposure and Human Health")

SYMPTOMS/DAMAGE:

Eye, ear and throat irritation;
Acidosis;
Acute sense of smell;
Altered tissue proteins;
Anemia;
Antibodies formation;
Apathy;
Blindness;
Blood in urine;
Blurred vision;
Body aches;
Bronchial spasms;
Bronchitis;
Burns, nasal and throat;
Cardiac impairment, palpations, and arrhythmias;
Central nervous system depression;
Changes in higher cognitive functions ;
Chemical sensitivity;
Chest pains and tightness;
Chronic vaginitis;
Colds;
Coma;
Conjunctivitis;
Constipation;
Convulsions;
Corneal erosion;
Cough;
Death;
Depression;
Dermatitis;
Diarrhea;
Difficulty Concentrating;
Disorientation;
Dizziness;
DNA damage;
Drowsiness;
Ear aches;
Eczema;
Emotional upsets;
Ethmoid polyps;
Fatigue;
Fecal Bleeding;
Fetal asphyxiation;
Flu-like or cold like illness;
Frequent urination with pain;
Gastritis;
Gastrointestinal inflammation;
Headaches;
Hemolytic anemia;
Hoarseness;
Hyperactive airway disease;
Hyperactivity;
Hypomenstrual syndrome;
Immune system sensitization;
Impaired attention span;
Impaired capacity to focus attention;
Inability or difficulty swallowing;
Inability to recall words and names;
Inconsistent IQ profiles;
Inflammatory diseases of the reproductive organs;
Intestinal pain;
Intrinsic asthma;
Irritability;
Jaundice;
Joint pain, aches and swelling;
Kidney pain;
Laryngeal spasm;
Loss of memory;
Loss of sense of smell;
Loss of taste;
Malaise;
Menstrual and testicular pain;
Menstrual irregularities;
Metallic taste;
Muscle spasms and cramps;
Nasal congestion, Crusting and mucosa inflammation;
Nausea;
Nosebleeds;
Numbness and tingling of the forearms and finger tips;
Pale, clammy skin;
Partial laryngeal paralysis;
Pneumonia;
Post nasal drip;
Pulmonary edema;
Reduced body temperature;
Retarded speech pattern;
Ringing or tingling in the ear;
Schizophrenic-type symptoms;
Sensitivity to sound;
Shock;
Short term memory loss;
Shortness of breath;
Skin lesions;
Sneezing;
Sore throat;
Spacey feeling;
Speaking difficulty;
Sterility;
Swollen glands;
Tearing;
Thirst;
Tracheitis:
Tracheobronchitis;
Vertigo;
Vomiting blood;
Vomiting;
Wheezing;
Suspected of causing cancer (see comment from NIOSH).
Genetic mutations;
Chromosomal damage;

Metabolized as formic acid. Note: Will cross sensitize to formic acid.
Comparison of ciliostatic effects showed formaldehyde to the most
toxic of the aldehydes. EPA estimates that 15 people in 1 million will
get cancer from lifetime exposure of 1 ppb.   Neurotoxin.

Trade Names/synonyms: Quaternium-15; Metanal; Meltyl aldehyde;
Methylene oxide; Formalin; Formic aldehyde; Formalith; Fyde; BVF;
Morbicid; Oxymethylene; Oxomethane; Lysoform; Superlysoform;
Fannoform; Ivalon.

NIOSH: Carcinogen at any exposure level;
NIOSH REL:     0.016 ppm (10 hr/day 40 hr. wk);
                          0.100 ppm (ceiling limit to not exceed 15
minutes);
OSHA:  PEL:     0.750 ppm (8 hr/day-40 hr/wk-PP/S);
                    2000 ppm (exposure to not exceed 15 min);
NAS:                  There is no (constant) population
                           threshold for irritation effects;
NRC:                  Fewer than 20% but perhaps no more 10% of the
general
                           population may be suspectable to formaldehyde
and may
                           react acutely at any exposure level;
ACGIH:              Suspected human carcinogen;
IDLH:                 30 ppm;

CEHH Page 182;
References: 84,17,18,30,31,129,278,279,285, 88,290,297,299,300,304,
305,309,388,389,394,416,417a,421,423,426,457.

    8. Berthold-Bond, A., Clean & Green, Woodstock, NY:
       Cress Press, 1990.
  14. Chesebrough-Ponds USA Co., product label for Rave All in One hair
       spray 1992.
  17. Concrete Facts, "99.99 Percent?" March 1991, Vol.1 no.1 and/or
    Rachel's Hazardous Waste News #207, "Hardardous Waste
    Incineration- Part 4; Real Alternatives to Incinerations,"
    November 14, 1988.
  18. "Congress: HR 1066 Needed to Turn Heat Up on Employers,
    Regulators, Congress Told", Indoor Air Pollution News,
    Washington, DC: Buraff, August 22, 1991.
  30. Lander Co., product label for Rose Scented Skin Cream, ca. 1992.
  31. Lander Co., product label for Vitamin E Lotion, ca. 1992.
129. "National Library of Medicine's Toxicology Information Program,
    Agency for Toxic Substances and Disease Registry, Hazardous
    Substances Data Bank, "Formaldehyde", as of January 11, 1992.
279. National Research Council, Assembly of Life Sciences, Committee
    on Aldehydes, Based on Toxicology and Environmental Health
    Hazards, Formaldehydes and other Aldehydes, Washington, DC:
    National Academy Press, 1981.
285. New Jersey Department of Health, "Hazardous Substance Fact Sheet
    "Formaldehyde", 1986.
288. Proctor and Gamble Co., label for Ivory Free Conditioner, U.S.
     patent pending.
290. Redmond Products, product label for Aussie Mega Shampoo with
     Papaya, 1986.
297. Swanson, J.R., "Formaldehyde: The Psychological and Educational
     Implications of Formaldehyde Toxicology," Seattle, WA:
     University of Washington, College of Education, 1984.
299.   Thomas, C.L., editor, Taber's Cyclopedic Medical Dictionary,
     16th Edition, Philadelphia, PA: F.A. Davis Company, 1989.
**********************************************************

Rich Murray:  Serious symptom syndrome summary:
Aspartame (NutraSweet, Equal, Canderel, Benevia) is reported by
scientific studies and case histories to be toxic: * headaches
* many body and joint pains (or burning, tingling, tremors, twitching,
spasms, cramps, or numbness)  *  fever, fatigue
* "mind fog", "feel unreal", poor memory, confusion, anxiety,
irritability, depression, mania, insomnia, dizziness, slurred speech,
ringing in ears, sexual problems,  poor vision, hearing, or taste
* red face, itching, rashes, burning eyes or throat,
dry mouth or eyes, mouth sores  *  hair loss
* obesity, bloating, edema, anorexia,
poor or excessive hunger or thirst    * breathing problems
*  nausea, diarrhea or constipation * coldness  * sweating
* racing heart, high blood pressure, erratic blood sugar levels
* seizures   * birth defects  * brain cancers  * addiction
* aggrivates diabetes, autism, ADHD,
and interstitial cystitis (bladder pain).

Almost all are typical of chronic methanol-formaldehyde toxicity:
for detailed review    http://www.dorway.com/barua.html
Journal Of The Diabetic Association Of  India
1995  Vol. 35, No. 4.  Emerging Facts About Aspartame
Dr. J. Barua (ophthalmic surgeon), Dr. Arun  Bal (surgeon)
(79 references)    barua@giasbm01.vsnl.net.in
"...the total amount of methanol absorbed will be approximately
10% of aspartame ingested. An EPA assessment of methanol states
that methanol "is considered a cumulative poison due to the low rate
of excretion once it is absorbed."  The absorbed methanol is then
slowly converted to formaldehyde..."
"Reaction of formaldehyde with DNA has been observed,
by spectrophotometry and electron microscopy, to result in
irreversible denaturation."

http://ww.presidiotex.com/barcelona/index.html
Trocho C, Pardo R, Rafecas I, Virgili J, Remesar X,
Fernandez-Lopez JA, Alemany M  ["Trok-ho"]
Formaldehyde derived from dietary aspartame binds to tissue
components in vivo.  Life Sci 1998 Jun 26; 63(5): 337-49.
Departament de Bioquimica i Biologia Molecular, Facultat de Biologia,
Universitat de Barcelona, Spain.
http://www.presidiotex.com/barcelona/index.html
Maria Alemany, PhD (male)  alemany@porthos.bio.ub.es

http://groups.yahoo.com/group/aspartameNM/message/830
RTM: Tholen: Diet Coke has 5 ppm formaldehyde from aspartame
5.29.2 rmforall
For 6 cans of diet soda, this is 5 times the daily limit of 1 PPM  for
formaldehyde in drinking water, set by the EPA.

http://www.dorway.com/wmonte.txt
Dr. Woodrow C. Monte  Aspartame: methanol, and the public health.
Journal of Applied Nutrition 1984;  36 (1):  42-54.
(62 references)   Professsor of Food Science
Director of the Food Science and Nutrition Laboratory
Arizona State University,  Tempe, Arizona 85287
6411 South River Drive #61 Tempe, Arizona 85283-3337
602-965-6938    woody.monte@asu.edu
The methanol from 2 L of diet soda, 5.6 12-oz cans, 20 mg/can, is
112 mg, 10% of the aspartame.  The EPA limit for water is 7.8 mg daily
for methanol (wood alcohol), a deadly cumulative poison. Many users
drink 1-2 L daily. The reported symptoms are entirely consistent
with chronic methanol toxicity. (Fresh orange juice has 34 mg/L, but,
like all juices, has 16 times more ethanol, which strongly protects
against methanol.)
**********************************************************

http://biz-comm.com/CIIN/who.htm
A History of the Chemical Injury Information Network
PO Box 301, White Sulphur Springs, MT 59645; (406) 547-2255

Founded in 1990, the Chemical Injury Information Network
(CIIN) is a 501(c)3, tax-exempt, non-profit support, advocacy
organization run by the chemically injured primarily for the benefit
of the chemically injured. Its primary focus is on education,
credible research on multiple chemical sensitivity (MCS), and the
empowerment of the chemically injured. CIIN publishes the
monthly newsletter Our Toxic Times and has over 5,000
members in 35 countries.*

CIIN merged with Cindy Duehring's Environmental Access
Research Network (EARN) in 1994. EARN now serves as the
research division of CIIN and is responsible for the administration
of one the largest private libraries on chemical health issues in
existence. Its primary focus is to make scientific, medical, legal,
and government literature available to health care professionals,
expert witnesses, attorneys, and lay persons. EARN publishes
Environmental Access Profiles and the semi-monthly newsletter
Medical & Legal Briefs.

In 1996, CIIN formed a new division to raise money to fund
research into MCS. The MCS Research Fund has a medical
advisory board that peer reviews and prioritizes research
proposals for funding.

Considered one of the leading organizations in the world for
chemical health problems, CIIN/EARN receives hundreds of
requests each month for information on toxic health problems.
They regularly work with health care professionals in Algeria,
Australia, Austria, Canada, Germany, India, Sweden, Venezuela,
United Kingdom, and the United States. They have worked with
universities in Australia, Canada, Germany, Philippines, Mexico,
and the United States. CIIN/EARN have also provided
information not only to the US government, but to the European
Union and the governments of Canada, Costa Rica, Finland, New
Zealand, and Venezuela. CIIN has received recognition for its
work on chemical health issues from the United Nations'
Environmental Programme and from the European Union.

In 1991, CIIN was accepted by the Agency for Toxic
Substances and Disease Registry (ATSDR) as a clearinghouse for
information on the adverse health effects of chemical exposures.
CIIN/EARN have also earned the respect of legislators with over
100 US Senators and Representatives referring their chemically
injured constituents to them. In addition, the National Institutes of
Health, the National Institute for Environmental Health Sciences,
the National Institute for Occupational Safety and Health, the
ATSDR, the Centers for Disease Control and Prevention, and
several divisions of the Environmental Protection Agency refer
people who have been chemically injured to CIIN/EARN.

Cindy Duehring, EARN's director, and Cynthia Wilson, CIIN's
executive director, were commissioned by the Chemical Impact
Project to write a "white paper" in 1994. The 65-page report,
The Human Consequences of the Chemical Problem (available
from TT Publishing, PO Box T, White Sulphur Springs MT
59645 for $7.20), was presented to Vice President Al Gore, First
Lady Hillary Rodham Clinton, Secretary of the National Institutes
of Health Donna Shalala, and the Centers for Disease Control and
Prevention (CDC). The CDC had the paper peer reviewed and it
was found to have "merit". A conference was convened to discuss
the health issues raised by the paper. The ATSDR called it
"powerful and well researched." The Special Assistant to the
President requested extra copies to distribute, and Senator
Conrad Burns (R-MT) requested an extra copy to present to the
Senate Committee on Labor and Human Resources.

From March 1993 to April 1994, Ms. Wilson served as a public
liaison officer and a member of the planning committee for the
ATSDR sponsored Conference on Low-Level Exposure to
Chemicals and Neurobiologic Sensitivity. She was also one of
three patients to make a presentation at the conference which she
did via telephone.

In 1994, CIIN/EARN initiated the steering committee for the
National Coalition for the Chemically Injured. Ms. Duehring and
Ms. Wilson co-chaired the committee. In 1995, the steering
committee finished the organizational plan for the coalition and
turned it over to an elected Board of Directors.

INTERNATIONAL AWARD

In December, Ms. Duehring was awarded the 1997 Right
Livelihood Award for her research into the sources and effects of
MCS. The Right Livelihood Award is known as the Alternative
Nobel Prize and is awarded to people working toward a
sustainable future.

At the request of the US Interagency Taskforce on Multiple
Chemical Sensitivities, CIIN prepared a report on MCS as a
global health problem. The report, written in 1995, documented
MCS health problems in 36 countries. CIIN was the only group
to be asked to make a presentation to the taskforce.

OUR TOXIC TIMES  The monthly magazine of CIIN

The Chemical Injury Information Network publishes a monthly
magazine called Our Toxic Times (OTT). It covers a wide range
of pertinent information for those concerned about Multiple
Chemical Sensitivity, from the technical to the practical. It also
contains advertisements, usually pertaining to living or dealing with
MCS or chemical injury. CIIN appreciates the support of these
advertisers but does NOT guarantee or endorse any products or
services. Also, the magazine is not a substitute for medical, legal,
or other professional services.

CIIN is interested in inquiries into writing articles for OTT. The
phone number for the magazine is the same as for the Chemical
Injury Information Network: 406-547-2255.

* Algeria, Argentina, Australia, Austria, Bahamas, Belgium,
Brazil, Canada, Costa Rica, Croatia, Czech Republic, Denmark,
England, Finland, France, Germany, Greece, Hong Kong, India,
Ireland, Mexico, New Zealand, Netherlands, Northern Ireland,
Norway, Pakistan, Philippines, Puerto Rico, Russia, Scotland,
South Africa, Sweden, United States, Venezuela, and Wales.

Our Toxic Times back issues. 7/90 to 6/94 - $1.50/copy;
7/94 to present - $3/copy. (Unless otherwise specified, the
most recent past issue(s) will be sent.)

Environmental Directory contains over 200 MCS support
groups and related environmental groups. $5

Non-Toxic Buying Guide lists products ranging form
less-toxic construction materials to personal hygiene products.
Over 200 suppliers. $7.50 (Low-income $5)

Chemical Injury Information Network Membership Directory.
$20 for 3.5"disk; $50 for print out. Upon request, a list of
CIIN members in your state will be provided at no cost. For a
copy of another state's members, please send $2 for the first
state and $1.50 for each additional state.

Chemical Profiles are fully referenced abstracts containing
trade names, synonyms, exposure standards, adverse health
effects, usage, and more. $2. per individual profile.

Bibliography of food allergy, MCS, and the health effects of
chemicals. Contains over 1,000 references. $10.40 Order
No. 0112-CIIN-xx-048R

Chemical Exposures contains the components of products in
everyday use. $2. Order No. 0229-CIIN-93-006R
**********************************************************

Rich Murray, MA    Room For All    rmforall@att.net
1943 Otowi Road, Santa Fe  NM  USA  87505   505-986-9103

http://groups.yahoo.com/group/aspartameNM/messages  for 863  posts
http://groups.yahoo.com/group/aspartameNM/message/861 brief summary
http://groups.yahoo.com/group/aspartameNM/message/862 long summary

http://groups.yahoo.com/group/aspartameNM/message/860
RTM: FDA: objections to neotame approval  (Section A) 8.4.2 rmforall
***********************************************************