LOCUS       HUMHBB      73308 bp ds-DNA             PRI       20-JAN-1994
 DEFINITION  Human beta globin region on chromosome 11.
 ACCESSION   U01317 J00179 J00093 J00094 J00096 J00158 J00159 J00160 J00161
             J00162 J00163 J00164 J00165 J00166 J00167 J00168 J00169 J00170
             J00171 J00172 J00173 J00174 J00175 J00177 J00178 K01239 K01890
             K02544 M18047 M19067 M24868 M24886 X00423 X00424 X00672
 KEYWORDS    Alu repeat; HPFH; KpnI repetitive sequence; RNA polymerase III;
             allelic variation; alternate cap site; beta-1 pseudogene;
             beta-globin; delta-globin; epsilon-globin; gamma-globin;
             gene duplication; globin; polymorphism; promoter mutation;
             pseudogene; repetitive sequence; thalassemia.
 SOURCE      Human mRNA, cDNA and DNA.
   ORGANISM  Homo sapiens
             Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
             Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
 REFERENCE   1  (bases 62409 to 62631; 63482 to 63610)
   AUTHORS   Marotta,C.A., Forget,B.G., Weissman,S.M., Verma,I.M.,
             McCaffrey,R.P. and Baltimore,D.
   TITLE     Nucleotide sequences of human globin messenger RNA
   JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 71, 2300-2304 (1974)
   STANDARD  full automatic
 REFERENCE   2  (bases 63602 to 63646)
   AUTHORS   Forget,B.G., Marotta,C.A., Weissman,S.M. and Cohen-Solal,M.M.
   TITLE     Nucleotide sequences of the 3'-terminal untranslated region of
             messenger RNA for human beta globin chain
   JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 72, 3614-3618 (1975)
   STANDARD  full automatic
 REFERENCE   3  (bases 63593 to 63626)
   AUTHORS   Proudfoot,N.J. and Brownlee,G.G.
   TITLE     Nucleotide sequences of globin messenger RNA
   JOURNAL   Br. Med. Bull. 32, 251-256 (1976)
   STANDARD  full automatic
 REFERENCE   4  (bases 63673 to 63743)
   AUTHORS   Proudfoot,N.J. and Longley,J.I.
   TITLE     The 3' terminal sequences of human alpha and beta globin messenger
             RNAs: Comparison with rabbit globin messenger RNA
   JOURNAL   Cell 9, 733-746 (1976)
   STANDARD  full automatic
 REFERENCE   5  (sites)
   AUTHORS   Proudfoot,N.J. and Brownlee,G.G.
   TITLE     Non-coding region sequences in eukaryotic messenger RNA
   JOURNAL   Nature 263, 211-214 (1976)
   STANDARD  full automatic
 REFERENCE   6  (bases 63596 to 63743)
   AUTHORS   Proudfoot,N.J.
   TITLE     Complete 3' noncoding region sequences of rabbit and human
             beta-globin messenger RNA's
   JOURNAL   Cell 10, 559-570 (1977)
   STANDARD  full automatic
 REFERENCE   7  (bases 62137 to 62193)
   AUTHORS   Baralle,F.E.
   TITLE     Complete nucleotide sequence of the 5' noncoding region of human
             alpha- and beta-globin mRNA
   JOURNAL   Cell 12, 1085-1095 (1977)
   STANDARD  full automatic
 REFERENCE   8  (sites)
   AUTHORS   Marotta,C.A., Forget,B.G., Cohen-Solal,M.M., Wilson,J.T. and
             Weissman,S.M.
   TITLE     Human beta-globin messenger RNA: I. Nucleotide sequences derived
             from complementary RNA
   JOURNAL   J. Biol. Chem. 252, 5019-5031 (1977)
   STANDARD  full automatic
 REFERENCE   9  (bases 62187 to 63610)
   AUTHORS   Cohen-Solal,M.M., Forget,B.G., Prensky,W., Marotta,C.A. and
             Weissman,S.M.
   TITLE     Human beta-globin messenger RNA: II. Nucleotide sequences derived
             from 125-I-labeled globin messenger RNA
   JOURNAL   J. Biol. Chem. 252, 5032-5039 (1977)
   STANDARD  full automatic
 REFERENCE   10  (bases 54790 to 54881; 62409 to 62631; 63482 to 63715)
   AUTHORS   Marotta,C.A., Wilson,J.T., Forget,B.G. and Weissman,S.M.
   TITLE     Human beta-globin messenger RNA. III. Nucleotide sequences derived
             from complementary DNA
   JOURNAL   J. Biol. Chem. 252, 5040-5053 (1977)
   STANDARD  full automatic
 REFERENCE   11  (bases 62137 to 62189)
   AUTHORS   Chang,J.C., Temple,G.F., Poon,R., Neumann,K.H. and Kan,Y.W.
   TITLE     The nucleotide sequences of the untranslated 5' regions of human
             alpha- and beta-globin mRNAs
   JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 74, 5145-5149 (1977)
   STANDARD  full automatic
 REFERENCE   12  (bases 56103 to 56184)
   AUTHORS   Lawn,R.M., Fritsch,E.F., Parker,R.C., Blake,G. and Maniatis,T.
   TITLE     The isolation and characterization of linked delta- and beta-globin
             genes from a library of human DNA
   JOURNAL   Cell 15, 1157-1174 (1978)
   STANDARD  full automatic
 REFERENCE   13  (bases 35854 to 35946; 63482 to 63531)
   AUTHORS   Little,P., Curtis,P., Coutelle,C., van den Berg,J., Dalgleish,R.,
             Malcolm,S., Courtney,M., Westaway,D. and Williamson,R.
   TITLE     Isolation and partial sequence of recombinant plasmids containing
             human alpha-, beta- and gamma-globin cDNA fragments
   JOURNAL   Nature 273, 640-643 (1978)
   STANDARD  full automatic
 REFERENCE   14  (bases 62187 to 63742)
   AUTHORS   Wilson,J.T., Wilson,L.B., DeRiel,J.K., Villa-Komaroff,L.,
             Efstratiadis,A., Forget,B.G. and Weissman,S.M.
   TITLE     Insertion of synthetic copies of human globin genes into bacterial
             plasmids
   JOURNAL   Nucleic Acids Res. 5, 563-581 (1978)
   STANDARD  full automatic
 REFERENCE   15  (bases 34478 to 34563; 39414 to 39499)
   AUTHORS   Chang,J.C., Poon,R., Neumann,K.H. and Kan,Y.W.
   TITLE     The nucleotide sequence of the 5' untranslated region of human
             gamma-globin mRNA
   JOURNAL   Nucleic Acids Res. 5, 3515-3522 (1978)
   STANDARD  full automatic
 REFERENCE   16  (bases 40839 to 40985)
   AUTHORS   Poon,R., Wai,K.Y. and Boyer,H.W.
   TITLE     Sequence of the 3' noncoding and adjacent regions of human
             gamma-globin mRNA
   JOURNAL   Nucleic Acids Res. 5, 4625-4630 (1978)
   STANDARD  full automatic
 REFERENCE   17  (bases 35826 to 35907; 40742 to 40823)
   AUTHORS   Smithies,O., Blechl,A.E., Denniston-Thompson,K., Newell,N.,
             Richards,J.E., Slightom,J.L., Tucker,P.W. and Blattner,F.R.
   TITLE     Cloning human fetal gamma globin and mouse alpha-type globin DNA:
             Characterization and partial sequencing
   JOURNAL   Science 202, 1284-1289 (1978)
   STANDARD  full automatic
 REFERENCE   18  (bases 34478 to 34536; 62137 to 62192; 63608 to 63742)
   AUTHORS   Kan,Y.W., Chang,C.S. and Poon,R.
   TITLE     Nucleotide sequences of the untranslated 5' and 3' regions of human
             alpha-, beta-, and gamma-globin mRNAS
   JOURNAL   (in) Stamatoyannopoulos,G. and Newhouse,A.W. (Eds.);
             CELLULAR AND MOLECULAR REGULATION OF HEMOGLOBIN SWITCHING:  0-0,
             Grune and Stratton, New York (1979)
   STANDARD  full automatic
 REFERENCE   19  (sites)
   AUTHORS   Chang,J.C. and Kan,Y.W.
   TITLE     Beta-0 thalassemia, a nonsense mutation in man
   JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 76, 2886-2889 (1979)
   STANDARD  full automatic
 REFERENCE   20  (bases 19846 to 19965)
   AUTHORS   Proudfoot,N.J. and Baralle,F.E.
   TITLE     Molecular cloning of human epsilon-globin gene
   JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 76, 5435-5439 (1979)
   STANDARD  full automatic
 REFERENCE   21  (sites)
   AUTHORS   Chang,J.C., Kan,Y.W., Trecartin,R.F. and Temple,G.F.
   TITLE     Nonsense mutation as a cause of beta-0 thalassemia
   JOURNAL   Ann. N. Y. Acad. Sci. 344, 113-119 (1980)
   STANDARD  full automatic
 REFERENCE   22  (sites)
   AUTHORS   Fritsch,E.F., Lawn,R.M. and Maniatis,T.
   TITLE     Molecular cloning and characterization of the human beta-like
             globin gene cluster
   JOURNAL   Cell 19, 959-972 (1980)
   STANDARD  full automatic
 REFERENCE   23  (bases 19462 to 21741)
   AUTHORS   Baralle,F.E., Shoulders,C.C. and Proudfoot,N.J.
   TITLE     The primary structure of the human epsilon-globin gene
   JOURNAL   Cell 21, 621-626 (1980)
   STANDARD  full automatic
 REFERENCE   24  (bases 34422 to 36069; 39358 to 40986)
   AUTHORS   Slightom,J.L., Blechl,A.E. and Smithies,O.
   TITLE     Human fetal G-gamma and A-gamma globin genes: complete nucleotide
             sequences suggest that DNA can be exchanged between these
             duplicated genes
   JOURNAL   Cell 21, 627-638 (1980)
   STANDARD  full automatic
 REFERENCE   25  (bases 54618 to 56602)
   AUTHORS   Spritz,R.A., DeRiel,J.K., Forget,B.G. and Weissman,S.M.
   TITLE     Complete nucleotide sequence of the human delta-globin gene
   JOURNAL   Cell 21, 639-646 (1980)
   STANDARD  full automatic
 REFERENCE   26  (bases 62034 to 64083)
   AUTHORS   Lawn,R.M., Efstratiadis,A., O'Connell,C. and Maniatis,T.
   TITLE     The nucleotide sequence of the human beta-globin gene
   JOURNAL   Cell 21, 647-651 (1980)
   STANDARD  full automatic
 REFERENCE   27  (sites)
   AUTHORS   Efstratiadis,A., Posakony,J.W., Maniatis,T., Lawn,R.M.,
             O'Connell,C., Spritz,R.A., DeRiel,J.K., Forget,B.G., Weissman,S.M.,
             Slightom,J.L., Blechl,A.E., Smithies,O., Baralle,F.E.,
             Shoulders,C.C. and Proudfoot,N.J.
   TITLE     The structure and evolution of the human beta-globin gene family
   JOURNAL   Cell 21, 653-668 (1980)
   STANDARD  full automatic
 REFERENCE   28  (bases 19864 to 19983)
   AUTHORS   Baralle,F.E., Shoulders,C.C., Goodbourn,S., Jeffreys,A. and
             Proudfoot,N.J.
   TITLE     The 5' flanking region of human epsilon-globin gene
   JOURNAL   Nucleic Acids Res. 8, 4393-4404 (1980)
   STANDARD  full automatic
 REFERENCE   29  (bases 32353 to 43728)
   AUTHORS   Shen,S.-H.H., Slightom,J.L. and Smithies,O.
   TITLE     A history of the human fetal globin gene duplication
   JOURNAL   Cell 26, 191-203 (1981)
   STANDARD  full automatic
 REFERENCE   30  (sites)
   AUTHORS   Busslinger,M., Moschonas,N. and Flavell,R.A.
   TITLE     +beta thalassemia: Aberrant splicing results from a single point
             mutation in an intron
   JOURNAL   Cell 27, 289-298 (1981)
   STANDARD  full automatic
 REFERENCE   31  (bases 32353 to 33218; 51978 to 52472)
   AUTHORS   Duncan,C.H., Jagadeeswaran,P., Wang,R.R. and Weissman,S.M.
   TITLE     Structural analysis of templates and RNA polymerase III transcripts
             of Alu family sequences interspersed among the human beta-like
             globin genes
   JOURNAL   Gene 13, 185-196 (1981)
   STANDARD  full automatic
 REFERENCE   32  (sites)
   AUTHORS   Orkin,S.H. and Goff,S.C.
   TITLE     Nonsense and frameshift mutations in beta-0-thalassemia detected in
             cloned beta-globin genes
   JOURNAL   J. Biol. Chem. 256, 9782-9784 (1981)
   STANDARD  full automatic
 REFERENCE   33  (bases 62454 to 62613)
   AUTHORS   Orkin,S.H., Goff,S.C. and Nathan,D.G.
   TITLE     Heterogeneity of DNA deletion in gamma-delta-beta-thalassemia
   JOURNAL   J. Clin. Invest. 67, 878-884 (1981)
   STANDARD  full automatic
 REFERENCE   34  (sites)
   AUTHORS   Trecartin,R.F., Liebhaber,S.A., Chang,J.C., Lee,K.Y., Kan,Y.W.,
             Furbetta,M., Angius,A. and Cao,A.
   TITLE     Beta-0 thalassemia in Sardinia is caused by a nonsense mutation
   JOURNAL   J. Clin. Invest. 68, 1012-1017 (1981)
   STANDARD  full automatic
 REFERENCE   35  (sites)
   AUTHORS   Westaway,D. and Williamson,R.
   TITLE     An intron nucleotide sequence variant in a cloned
             beta-plus-thalassemia globin gene
   JOURNAL   Nucleic Acids Res. 9, 1777-1787 (1981)
   STANDARD  full automatic
 REFERENCE   36  (sites)
   AUTHORS   Moschonas,N., de Boer,E., Grosveld,F.G., Dahl,H.-H.M., Wright,S.,
             Shewmaker,C.K. and Flavell,R.A.
   TITLE     Structure and expression of a cloned beta-0 thalassemic globin gene
   JOURNAL   Nucleic Acids Res. 9, 4391-4401 (1981)
   STANDARD  full automatic
 REFERENCE   37  (bases 60489 to 60948)
   AUTHORS   Spritz,R.A.
   TITLE     Duplication/deletion polymorphism 5'- to the human beta globin gene
   JOURNAL   Nucleic Acids Res. 9, 5037-5047 (1981)
   STANDARD  full automatic
 REFERENCE   38  (bases 59345 to 59593)
   AUTHORS   Miesfeld,R., Krystal,M. and Arnheim,N.
   TITLE     A member of a new repeated sequence family which is conserved
             throughout eukaryotic evolution is found between the human delta
             and beta globin genes
   JOURNAL   Nucleic Acids Res. 9, 5931-5947 (1981)
   STANDARD  full automatic
 REFERENCE   39  (bases 16595 to 17840)
   AUTHORS   Di Segni,G., Carrara,G., Tocchini-Valentini,G.R., Shoulders,C.C.
             and Baralle,F.E.
   TITLE     Selective in vitro transcription of one of the two Alu family
             repeats present in the 5' flanking region of the human
             epsilon-globin gene
   JOURNAL   Nucleic Acids Res. 9, 6709-6722 (1981)
   STANDARD  full automatic
 REFERENCE   40  (sites)
   AUTHORS   Adams,J.G.III., Steinberg,M.H., Newman,M.V., Morrison,W.T.,
             Benz,E.J.Jr.. and Iyer,R.
   TITLE     Beta-thalassemia present in cis to a new beta-chain structural
             variant, Hb Vicksburg [beta75(e19)leu->0]
   JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 78, 469-473 (1981)
   STANDARD  full automatic
 REFERENCE   41  (bases 61921 to 63824)
   AUTHORS   Spritz,R.A., Jagadeeswaran,P., Choudary,P.V., Biro,P.A.,
             Elder,J.T., DeRiel,J.K., Manley,J.L., Gefter,M.L., Forget,B.G. and
             Weissman,S.M.
   TITLE     Base substitution in an intervening sequence of a
             beta-plus-thalassemic human globin gene
   JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 78, 2455-2459 (1981)
   STANDARD  full automatic
 REFERENCE   42  (sites)
   AUTHORS   Baird,M., Driscoll,C., Schreiner,H., Sciarratta,G.V., Sansone,G.,
             Niazi,G., Ramirez,F. and Bank,A.
   TITLE     A nucleotide change at a splice junction in the human beta-globin
             gene is associated with beta-0-thalassemia
   JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 78, 4218-4221 (1981)
   STANDARD  full automatic
 REFERENCE   43  (sites)
   AUTHORS   Grosveld,F., Busslinger,M., Grosveld,G., Groffen,J., DeKleine,A.
             and Flavell,R.A.
   TITLE     The structure and expression of the haemoglobin genes
   JOURNAL   Adv. Exp. Med. Biol. 158, 65-80 (1982)
   STANDARD  full automatic
 REFERENCE   44  (sites)
   AUTHORS   Treisman,R., Proudfoot,N.J., Shander,M. and Maniatis,T.
   TITLE     A single-base change at a splice site in a 0-beta-thalassemic gene
             causes abnormal RNA splicing
   JOURNAL   Cell 29, 903-911 (1982)
   STANDARD  full automatic
 REFERENCE   45  (bases 63823 to 64083)
   AUTHORS   Poncz,M., Ballantine,M., Solowiejczyk,D., Barak,I., Schwartz,E. and
             Surrey,S.
   TITLE     Beta-thalassemia in a Kurdish Jew: Single base changes in the
             T-A-T-A box
   JOURNAL   J. Biol. Chem. 257, 5994-5996 (1982)
   STANDARD  full automatic
 REFERENCE   46  (bases 61873 to 62198; 62375 to 62448)
   AUTHORS   Gorski,J., Fiori,M. and Mach,B.
   TITLE     A new nonsense mutation as the molecular basis for beta-0
             thalassemia
   JOURNAL   J. Mol. Biol. 154, 537-540 (1982)
   STANDARD  full automatic
 REFERENCE   47  (bases 50716 to 51215)
   AUTHORS   Jagadeeswaran,P., Tuan,D., Forget,B.G. and Weissman,S.M.
   TITLE     A gene deletion ending at the midpoint of a repetitive DNA sequence
             in one form of hereditary persistence of fetal haemoglobin
   JOURNAL   Nature 296, 469-470 (1982)
   STANDARD  full automatic
 REFERENCE   48  (sites)
   AUTHORS   Orkin,S.H., Kazazian,H.H.Jr.., Antonarakis,S.E., Goff,S.C.,
             Boehm,C.D., Sexton,J.P., Waber,P.G. and Giardina,P.J.
   TITLE     Linkage of beta-thalassemia mutations and beta-globin gene
             polymorphisms with DNA polymorphisms in human beta-globin gene
             cluster
   JOURNAL   Nature 296, 627-631 (1982)
   STANDARD  full automatic
 REFERENCE   49  (sites)
   AUTHORS   Ottolenghi,S. and Giglioni,B.
   TITLE     The deletion in a type of delta-0-beta-0-thalassemia begins in an
             inverted AluI repeat
   JOURNAL   Nature 300, 770-771 (1982)
   STANDARD  full automatic
 REFERENCE   50  (bases 62651 to 62715)
   AUTHORS   Spence,S.E., Pergolizzi,R.G., Donovan-Peluso,M., Kosche,K.A.,
             Dobkin,C.S. and Bank,A.
   TITLE     Five nucleotide changes in the large intervening sequence of a beta
             globin gene in a beta-plus thalassemia patient
   JOURNAL   Nucleic Acids Res. 10, 1283-1294 (1982)
   STANDARD  full automatic
 REFERENCE   51  (bases 60676 to 62137)
   AUTHORS   Moschonas,N., de Boer,E. and Flavell,R.A.
   TITLE     The DNA sequence of the 5' flanking region of the human beta-globin
             gene: Evolutionary conservation and polymorphic differences
   JOURNAL   Nucleic Acids Res. 10, 2109-2120 (1982)
   STANDARD  full automatic
 REFERENCE   52  (sites)
   AUTHORS   Allan,M., Grindlay,G.J., Stefani,L. and Paul,J.
   TITLE     Epsilon globin gene transcripts originating upstream of the mRNA
             cap site in K562 cells and normal human embryos
   JOURNAL   Nucleic Acids Res. 10, 5133-5147 (1982)
   STANDARD  full automatic
 REFERENCE   53  (sites)
   AUTHORS   Kinniburgh,A.J., Maquat,L.E., Schedl,T., Rachmilewitz,E. and
             Ross,J.
   TITLE     mRNA-deficient beta-0-thalassemia results from a single nucleotide
             deletion
   JOURNAL   Nucleic Acids Res. 10, 5421-5427 (1982)
   STANDARD  full automatic
 REFERENCE   54  (bases 54438 to 54740)
   AUTHORS   Kimura,A., Matsunaga,E., Ohta,Y., Fujiyoshi,T., Matsuo,T.,
             Nakamura,T., Imamura,T., Yanase,T. and Takagi,Y.
   TITLE     Structure of cloned delta-globin genes from a normal subject and a
             patient with delta-thalassemia; sequence polymorphisms found in the
             delta-globin gene region of Japanese individuals
   JOURNAL   Nucleic Acids Res. 10, 5725-5732 (1982)
   STANDARD  full automatic
 REFERENCE   55  (bases 10410 to 13774)
   AUTHORS   Shen,S.-H.H. and Smithies,O.
   TITLE     Human globin pseudo-beta-2 is not a globin-related sequence
   JOURNAL   Nucleic Acids Res. 10, 7809-7818 (1982)
   STANDARD  full automatic
 REFERENCE   56  (sites)
   AUTHORS   Spritz,R.A. and Orkin,S.H.
   TITLE     Duplication followed by deletion accounts for the structure of an
             Indian deletion beta-0-thalassemia gene
   JOURNAL   Nucleic Acids Res. 10, 8025-8029 (1982)
   STANDARD  full automatic
 REFERENCE   57  (bases 62373 to 62421)
   AUTHORS   Flavell,R.A., Bud,H., Bullman,H., Busslinger,M., de Boer,E., de
             Kleine,A., Golden,L., Groffen,J., Grosveld,F.G., Mellor,A.L.,
             Moschonas,N. and Weiss,E.
   TITLE     The structure and expression of mammalian gene clusters
   JOURNAL   Prog. Clin. Biol. Res. 103, 37-55 (1982)
   STANDARD  full automatic
 REFERENCE   58  (sites)
   AUTHORS   Ley,T.J. and Nienhuis,A.W.
   TITLE     A weak upstream promoter gives rise to long human beta-globin RNA
             molecules
   JOURNAL   Biochem. Biophys. Res. Commun. 112, 1041-1048 (1983)
   STANDARD  full automatic
 REFERENCE   59  (sites)
   AUTHORS   Carlson,D.P. and Ross,J.
   TITLE     Human beta-globin promoter and coding sequences transcribed by RNA
             polymerase III
   JOURNAL   Cell 34, 857-864 (1983)
   STANDARD  full automatic
 REFERENCE   60  (sites)
   AUTHORS   Allan,M., Lanyon,W.G. and Paul,J.
   TITLE     Multiple origins of transcription in the 4.5 kb upstream of the
             epsilon-globin gene
   JOURNAL   Cell 35, 187-197 (1983)
   STANDARD  full automatic
 REFERENCE   61  (sites)
   AUTHORS   Vanin,E.F., Henthorn,P.S., Kioussis,D., Grosveld,F. and Smithies,O.
   TITLE     Unexpected relationships between four large deletions in the human
             beta-globin gene cluster
   JOURNAL   Cell 35, 701-709 (1983)
   STANDARD  full automatic
 REFERENCE   62  (bases 50744 to 67204)
   AUTHORS   Poncz,M., Schwartz,E., Ballantine,M. and Surrey,S.
   TITLE     Nucleotide sequence analysis of the delta-beta-globin gene region
             in humans
   JOURNAL   J. Biol. Chem. 258, 11599-11609 (1983)
   STANDARD  full automatic
 REFERENCE   63  (bases 62050 to 62050; 62279 to 62279; 62283 to 62283)
   AUTHORS   Treisman,R., Orkin,S.H. and Maniatis,T.
   TITLE     Specific transcription and RNA splicing defects in five cloned
             beta-thalassaemia genes
   JOURNAL   Nature 302, 591-596 (1983)
   STANDARD  full automatic
 REFERENCE   64  (bases 62190 to 62244)
   AUTHORS   Chang,J.C., Alberti,A. and Kan,Y.W.
   TITLE     A beta-thalassemia lesion abolishes the same MstII site as the
             sickle mutation
   JOURNAL   Nucleic Acids Res. 11, 7789-7794 (1983)
   STANDARD  full automatic
 REFERENCE   65  (bases 50716 to 53976)
   AUTHORS   Maeda,N., Bliska,J.B. and Smithies,O.
   TITLE     Recombination and balanced chromosome polymorphism suggested by DNA
             sequences 5' to the human delta-globin gene
   JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 80, 5012-5016 (1983)
   STANDARD  full automatic
 REFERENCE   66  (sites)
   AUTHORS   Kimura,A., Ohta,Y., Fukumaki,Y. and Takagi,Y.
   TITLE     A fusion gene in man: DNA sequence analysis of the abnormal globin
             gene of hemoglobin Miyada
   JOURNAL   Biochem. Biophys. Res. Commun. 119, 968-974 (1984)
   STANDARD  full automatic
 REFERENCE   67  (sites)
   AUTHORS   Kazazian,H.H.Jr.., Orkin,S.H., Antonarakis,S.E., Sexton,J.P.,
             Boehm,C.D. and Waber,P.G.
   TITLE     Molecular characterization of seven beta-thalassemia mutations in
             Asian Indians
   JOURNAL   EMBO J. 3, 593-596 (1984)
   STANDARD  full automatic
 REFERENCE   68  (sites)
   AUTHORS   Guida,S., Giglioni,B., Ottolenghi,S., Camaschella,C. and Saglio,G.
   TITLE     The beta-globin gene in Sardinian delta-beta-0-thalassemia carries
             a C -> T nonsense mutation at codon 39
   JOURNAL   EMBO J. 3, 785-787 (1984)
   STANDARD  full automatic
 REFERENCE   69  (sites)
   AUTHORS   Giglioni,B., Casini,C., Mantovani,R.M., Merli,S., Comi,P.,
             Ottolenghi,S., Saglio,G., Camaschella,C. and Mazza,U.
   TITLE     A molecular study of a family with Greek hereditary persistence of
             fetal hemoglobin and beta-thalassemia
   JOURNAL   EMBO J. 3, 2641-2645 (1984)
   STANDARD  full automatic
 REFERENCE   70  (bases 61557 to 61623)
   AUTHORS   Semenza,G.L., Malladi,P., Surrey,S., Delgrosso,K., Poncz,M. and
             Schwartz,E.
   TITLE     Detection of a novel DNA polymorphism in the beta-globin gene
             cluster
   JOURNAL   J. Biol. Chem. 259, 6045-6048 (1984)
   STANDARD  full automatic
 REFERENCE   71  (sites)
   AUTHORS   Orkin,S.H., Antonarakis,S.E. and Kazazian,H.H.Jr..
   TITLE     Base substitution at position -88 in a beta-thalassemic globin gene
   JOURNAL   J. Biol. Chem. 259, 8679-8681 (1984)
   STANDARD  full automatic
 REFERENCE   72  (bases 45336 to 47463)
   AUTHORS   Chang,L.Y. and Slightom,J.L.
   TITLE     Isolation and nucleotide sequence analysis of the beta-type globin
             pseudogene from human, gorilla and chimpanzee
   JOURNAL   J. Mol. Biol. 180, 767-784 (1984)
   STANDARD  full automatic
 REFERENCE   73  (sites)
   AUTHORS   Grindlay,G.J., Lanyon,W.G., Allan,M. and Paul,J.
   TITLE     Alternative sites of transcription initiation upstream of the
             canonical cap site in human gamma-globin and beta-globin genes
   JOURNAL   Nucleic Acids Res. 12, 1811-1821 (1984)
   STANDARD  full automatic
 REFERENCE   74  (sites)
   AUTHORS   Stoeckert,C.J., Collins,F.S. and Weissman,S.M.
   TITLE     Human fetal globin DNA sequences suggest novel conversion event
   JOURNAL   Nucleic Acids Res. 12, 4469-4479 (1984)
   STANDARD  full automatic
 REFERENCE   75  (sites)
   AUTHORS   Mager,D.L. and Henthorn,P.S.
   TITLE     Identification of a retrovirus-like repetitive element in human DNA
   JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 81, 7510-7514 (1984)
   STANDARD  full automatic
 REFERENCE   76  (bases 19120 to 61776)
   AUTHORS   Collins,F.S. and Weissman,S.M.
   TITLE     The molecular genetics of human hemoglobin
   JOURNAL   Prog. Nucleic Acid Res. Mol. Biol. 31, 315-462 (1984)
   STANDARD  full automatic
 REFERENCE   77  (bases 34276 to 34276; 34282 to 34282; 34321 to 34321)
   AUTHORS   Gilman,J.G. and Huisman,T.H.
   TITLE     DNA sequence variation associated with elevated fetal gamma-G
             globin production
   JOURNAL   Blood 66, 783-787 (1985)
   STANDARD  full automatic
 REFERENCE   78  (sites)
   AUTHORS   Ruskin,B., Greene,J.M. and Green,M.R.
   TITLE     Cryptic branch point activation allows accurate in vitro splicing
             of human beta-globin intron mutants
   JOURNAL   Cell 41, 833-844 (1985)
   STANDARD  full automatic
 REFERENCE   79  (sites)
   AUTHORS   Lang,K.M. and Spritz,R.A.
   TITLE     Cloning specific complete polyadenylated 3'-terminal cDNA segments
   JOURNAL   Gene 33, 191-196 (1985)
   STANDARD  full automatic
 REFERENCE   80  (bases 1 to 16593)
   AUTHORS   Li,Q., Powers,P.A. and Smithies,O.
   TITLE     Nucleotide sequence of 16 kilobase pairs of DNA 5' to the human
             epsilon-globin gene
   JOURNAL   J. Biol. Chem. 260, 14901-14910 (1985)
   STANDARD  full automatic
 REFERENCE   81  (sites)
   AUTHORS   Gelinas,R., Endlich,B., Pfeiffer,C., Yagi,M. and
             Stamatoyannopoulos,G.
   TITLE     G to A substitution in the distal CCAAT box of the
             alpha-gamma-globin gene in Greek hereditary persistence of fetal
             haemoglobin
   JOURNAL   Nature 313, 323-325 (1985)
   STANDARD  full automatic
 REFERENCE   82  (sites)
   AUTHORS   Collins,F.S., Metherall,J.E., Yamakawa,M., Pan,J., Weissman,S.M.
             and Forget,B.G.
   TITLE     A point mutation in the alpha-gamma-globin gene promoter in Greek
             hereditary persistence of fetal haemoglobin
   JOURNAL   Nature 313, 325-326 (1985)
   STANDARD  full automatic
 REFERENCE   83  (bases 67071 to 73308)
   AUTHORS   Hattori,M., Hidaka,S. and Sakaki,Y.
   TITLE     Sequence analysis of a KpnI family member near the 3'end of human
             beta-globin gene
   JOURNAL   Nucleic Acids Res. 13, 7813-7827 (1985)
   STANDARD  full automatic
 REFERENCE   84  (sites)
   AUTHORS   van Santen,V.L. and Spritz,R.A.
   TITLE     mRNA precursor splicing in vivo: Sequence requirements determined
             by deletion analysis of an intervening sequence
   JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 82, 2885-2889 (1985)
   STANDARD  full automatic
 REFERENCE   85  (sites)
   AUTHORS   Tuan,D., Solomon,W., Li,Q. and London,I.M.
   TITLE     The 'beta-like-globin' gene domain in human erythroid cells
   JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 82, 6384-6388 (1985)
   STANDARD  full automatic
 REFERENCE   86  (sites)
   AUTHORS   Chabot,B., Black,D.L., LeMaster,D.M. and Steitz,J.A.
   TITLE     The 3' splice site of pre-messenger RNA is recognized by a small
             nuclear ribonucleoprotein
   JOURNAL   Science 230, 1344-1349 (1985)
   STANDARD  full automatic
 REFERENCE   87  (bases 21354 to 21360)
   AUTHORS   Collins,F.S.
   JOURNAL   Unpublished (1986)
   STANDARD  full automatic
 REFERENCE   88  (bases 58799 to 58958; 63036 to 63295)
   AUTHORS   Popovich,B.W., Rosenblatt,D.S., Kendall,A.G. and Nishioka,Y.
   TITLE     Molecular characterization of an atypical beta-thalassemia caused
             by a large deletion in the 5' beta-globin gene region
   JOURNAL   Am. J. Hum. Genet. 39, 797-810 (1986)
   STANDARD  full automatic
 REFERENCE   89  (bases 54874 to 54892)
   AUTHORS   Lapoumeroulie,C., Pagnier,J., Bank,A., Labie,D. and
             Krishnmoorthy,R.
   TITLE     Beta thalassemia due to a novel mutation in IVS 1 sequence donor
             site consensus sequence creating a restriction site
   JOURNAL   Biochem. Biophys. Res. Commun. 139, 709-713 (1986)
   STANDARD  full automatic
 REFERENCE   90  (bases 62373 to 62419)
   AUTHORS   Metherall,J.E., Collins,F.S., Pan,J., Weissman,S.M. and Forget,B.G.
   TITLE     Beta-0 thalassemia caused by a base substitution that creates an
             alternative splice acceptor site in an intron
   JOURNAL   EMBO J. 5, 2551-2557 (1986)
   STANDARD  full automatic
 REFERENCE   91  (bases 37640 to 37677; 40162 to 40199)
   AUTHORS   Tate,V.E., Hill,A.V., Bowden,D.K., Sadler,J.R., Weatherall,D.J. and
             Clegg,J.B.
   TITLE     A silent deletion in the beta-globin gene cluster
   JOURNAL   Nucleic Acids Res. 14, 4743-4750 (1986)
   STANDARD  full automatic
 REFERENCE   92  (sites)
   AUTHORS   Prchal,J.T., Cashman,D.P. and Kan,Y.W.
   TITLE     Hemoglobin Long Island is caused by a single mutation (adenine to
             cytosine) resulting in a failure to cleave amino-terminal
             methionine
   JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 83, 24-27 (1986)
   STANDARD  full automatic
 REFERENCE   93  (bases 59589 to 59718; 72211 to 72340)
   AUTHORS   Gilman,J.G. and Abraham,J.
   TITLE     DNA sequence analysis of the Dutch beta-0-thalassemia deletion
   JOURNAL   Biomed. Biochim. Acta 46, 131-135 (1987)
   STANDARD  full automatic
 REFERENCE   94  (bases 43723 to 50721)
   AUTHORS   Miyamoto,M.M., Slightom,J.L. and Goodman,M.
   TITLE     Phylogenetic relations of humans and African apes from DNA
             sequences in the pseudo-eta-globin region
   JOURNAL   Science 238, 369-373 (1987)
   STANDARD  full automatic
 REFERENCE   95  (sites)
   AUTHORS   Fei,Y.J., Stoming,T.A., Efremov,G.D., Efremov,D.G., Battacharia,R.,
             Gonzalez-Redondo,J.M., Altay,C., Gurgey,A. and Huisman,T.H.
   TITLE     Beta-thalassemia due to a T->A mutation within the ATA box
   JOURNAL   Biochem. Biophys. Res. Commun. 153, 741-747 (1988)
   STANDARD  full automatic
 REFERENCE   96  (bases 55038 to 55052)
   AUTHORS   Atweh,G.F., Brickner,H.E., Zhu,X.-X., Kazazian,H.H.Jr.. and
             Forget,B.G.
   TITLE     New amber mutation in a beta-thalassemic gene with nonmeasurable
             levels of mutant messenger RNA in vivo
   JOURNAL   J. Clin. Invest. 82, 557-561 (1988)
   STANDARD  full automatic
 REFERENCE   97  (sites)
   AUTHORS   Engelke,D.R., Hoener,P.A. and Collins,F.S.
   TITLE     Direct sequencing of enzymatically amplified human genomic DNA
   JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 85, 544-548 (1988)
   STANDARD  full automatic
 REFERENCE   98  (sites)
   AUTHORS   Guidal,C., Lapoumeroulie,C., Krishnamoorthy,R. and Elion,J.
   TITLE     Sequence correction and reassignment of the TaqI polymorphic site
             in the human inter-gamma-globin gene region, an African-specific
             marker
   JOURNAL   Unpublished (1993)
   STANDARD  full automatic
 REFERENCE   99  (bases 16594 to 19305)
   AUTHORS   Trepicchio,W.L., Dyer,M.A., Hardison,R.G. and Baron,M.H.
   TITLE     Upstream regulatory region of the human embryonic beta-like globin
             gene, epsilon
   JOURNAL   DNA Sequence (1993) Submitted
   STANDARD  full automatic
 COMMENT     [1]  cRNA fragments.
             [2]  mRNA.
             [5]  sites; polyadenylation signal and site for the beta gene.
             [4]  cDNA from normal and thalassemic mRNAs.
             [6]  cDNA.
             [9]  mRNA and cDNA fragments.
             [10]  mRNA.
             [7]  cDNA.
             [13]  see comment below for 35854 to 35946 - may be 40770 to 40862.
             [19]  sites; amber mutation at codon 17 of the beta chain.
             [22]  sites; gene order for the beta-like globin cluster.
             [27]  sites; consensus sequences in the promoter regions.
             [40]  sites; mutation associated with Hb Vicksburg.
             [41]  beta thalassemia DNA.
             [42]  sites; mutation associated with beta-0 thalassemia.
             [35]  sites; mutation associated with beta-plus thalassemia.
             [36]  sites; mutation associated with beta-0 thalassemia.
             [37]  six alleles over this span.
             [32]  sites; mutations associated with beta-0 thalassemia.
             [34]  sites; mutation associated with beta-0 thalassemia.
             [52]  sites; alternative cap sites for mRNA.
             [53]  sites; mutation associated with beta-plus thalassemia.
             [56]  sites; deletion mutation associated with beta-0 thalassemia.
             [48]  sites; mutations associated with beta thalassemias.
             [49]  sites; deletion mutation; for sequence, see separate entry.
             [62]  DNA from Kurdish Jew with thalassemia.
             [58]  sites; promoter region for beta gene.
             [59]  sites; termini for RNA polymerase III transcripts.
             [60]  sites; alternative cap sites for mRNA.
             [61]  sites; deletion mutations associated with thalassemias;.
             [65]  for the R allele;.
             [73]  sites; beta and gamma gene cap sites.
             [71]  sites; mutation associated with beta thalassemia.
             [66]  sites; Miyada Hb lesion; for sequence, see separate entry.
             [75]  sites; hsRTVL-H element; for sequence, see separate entry.
             [67]  sites; mutations associated with thalassemia.
             [68]  sites; mutation associated with thalassemia.
             [69]  sites; mutation associated with thalassemia.
             [76]  see comment; review.
             [74]  sites; mutations in the A-gamma gene.
             [81]  sites; mutation in promoter region leading to HPFH;.
             [82]  sites; mutation in promoter region leading to HPFH.
             [85]  sites; DNAse I hypersensitivity sites in the region.
             [78]  sites; cryptic branch points in beta IVS1.
             [79]  sites; 3' segments of beta and G-gamma cDNAs.
             [84]  sites; mutational analysis of G-gamma IVS-2.
             [86]  sites; small nuclear ribonucleoprotein binding site to mRNA.
             [92]  sites; hemoglobin Long Island mutation.
             [94]  revises [72].
             [95]  sites; mutations resulting in beta-thalassemia.
             [97]  sites; sickle cell anemia mutation site.
             [30]  sites; thalassemia mutations.
             [43]  sites; thalassemia mutations.
             [44]  sites; thalassemia mutation.
             [21]  sites; thalassemia mutation.
             [90]  beta-0 thalassemia mutations.
              
             This 73 kb sequence, which includes all of the known beta genes in
             the cluster on chromosome 11, was compiled from the following
             sources primarily:
              
                 bases             references
                 ------           ------------
              
                1 to 10409           [80]
                10410 to 13774       [55]
                13775 to 16594       [80]
                16595 to 19304       [99]
                19305 to 21381       [23], [28], [39]
                21382 to 32352       [63; see acknowledgments therein; bases
             31888-32020 sequenced on one strand only]
                32353 to 43728       [29]
                43729 to 50715       [94]
                50716 to 67204       [47], [62]
                67205 to 73308       [83]
              
             Other sequence work is referenced and annotated below. Oliver
             Smithies provided the sequence in [80] via Arpanet and Francis
             Collins supplied a diskette with the sequence in [76].
             Computer-readable sequence for [94] kindly provided by
             M.M.Miyamoto, 15-FEB-1988.
              
             The five beta-like globin genes are found within a 45 kb cluster on
             chromosome 11 in the following order:
              
                   5'-epsilon -G-gamma -A-gamma -delta -beta-3'   [22]
              
             Additionally, the pseudogene beta-1 is located between the A-gamma
             and delta genes [72]. A region 5' to the epsilon gene was thought
             to be another pseudogene; however [55] shows this not to be so.
             These embryonic, fetal and adult beta-like genes have the same
             overall exonic structure, leading to the conclusion that they are
             derived from one ancestral gene. In particular, they have many
             consensus sequences and repetitive sequences in common which have
             been analyzed by [27] and [76].
              
                    Epsilon gene
                    ------------
              
             The epsilon globin gene (hbe below) is normally expressed in the
             embryonic yolk sac: two epsilon chains together with two zeta
             chains (an alpha-like globin; see separate entry) constitute the
             embryonic hemoglobin Hb Gower I; two epsilon chains together with
             two alpha chains form the embryonic Hb Gower II.  Both of these
             embryonic hemoglobins are normally supplanted by fetal, and later,
             adult hemoglobin.
              
             The promoter region sequences 'ccaat', 'ata' and 'cttccg' found at
             19403, 19458 and 19495 are characteristic of all human beta-like
             genes, as well as of some other mammalian genes, and are thought to
             influence initiation of transcription and translation [27],[76].
             However, at least nine alternative cap sites which do not possess
             these conserved sequences have been found upstream from the
             so-called canonical cap sites at 19486 and 19488 [52],[60].
              
             The Alu family sequences found at 16892-17158 and 17927-18190 are
             typical of the 5' flanking regions of the beta-like globin genes
             [23],[39]. The first of these bipolar repeats has been shown to be
             active as a template for RNA polymerase III [39].
              
                    G-gamma and A-gamma genes
                    -------------------------
              
             The gamma globin genes (hbgg and hbga below) are normally expressed
             in the fetal liver, spleen and bone marrow.  Two gamma chains
             together with two alpha chains constitute fetal hemoglobin (HbF)
             which is normally replaced by adult hemoglobin (HbA) at birth.  In
             some beta-thalassemias and related conditions (HPFH or 'hereditary
             persistence of fetal hemoglobin'), gamma chain production continues
             into adulthood.  The mapping of deletions in these pathologies is
             therefore of special interest with regard to developmental control
             mechanisms.
              
             The two types of gamma chains differ at residue 136 where glycine
             is found in the G-gamma product and alanine is found in the A-gamma
             product.  The former is predominant at birth.  Because of the
             sequence identity of the two genes over large stretches, it was not
             always possible in the early work to know which sequence was being
             investigated [13],[15],[17].  Moreover, because allelic variation
             has been reported for each of these non-allelic genes, further
             sequence work is required to determine the consensus sequence for
             each.  Thus far the sequences of two A-gamma alleles have been
             reported ([24]; see separate entry which annotates the allelic
             variation).  The second introns for the hbgg and hbga genes shown
             below contain 886 and 866 bases respectively, while their alleles
             on the opposing chromosome have 904 and 876 bases for the
             corresponding introns.  [24] and [29] present an analysis of this
             phenomenon and conclude that intergenic exchange can occur in human
             germ line cells with significant frequency.
              
             Given the above-mentioned uncertainties with regard to polymorphism
             and material, differences, where annotated, are treated as
             variations rather than as conflicts.
              
             The promoter region sequences 'ccaat', 'ata' and 'cttctg' found at
             bases 34390, 34448 and 34485 in the hbgg gene, and bases 39326,
             39384 and 39421 in the hbga gene, are characteristic of all
             beta-like genes, as well as of some other mammalian genes, and are
             thought to influence transcription and translation [27],[76].  The
             gamma genes each manifest duplicate 'ccaat' boxes at positions
             34363 (hbgg) and 39299 (hbga).  Alternative cap sites are active in
             vitro upstream from the canonical cap sites at 34478 and 39414: at
             bases 34398, 34408, 34418 and 34428 for hbgg, and at bases 39334,
             39344, 39354 and 39364 for hbga [73].  Alternative cap sites have
             also been reported for epsilon and beta mRNAs when there is no
             duplication of the 'ccaat' sequence.  [81] and [82] show that the
             distal 'ccaat' box for the hbga gene (for the B allele -- see
             separate sequence) has some vital function: a g -> a mutation at
             base 39297 is apparently responsible for one form of Greek HPFH.
              
             The Alu family sequences found at bases 32390-32723 (approx.) and
             37325-37562 (approx.) are typical of the beta-like globin Alu's
             [27],[76],[31],[29].  A study of the hbgg repeat has revealed RNA
             transcription by polymerase III [31]( also reported for Alu regions
             in the 5' flanks of the epsilon and beta genes).
              
                    Pseudo-beta-1
                    -------------
              
             Human, gorilla and chimpanzee beta-like pseudogenes were sequenced
             and compared (see separate entries for the other primate sequences)
             by [72] and revised by [94]. The pseudogene structure was deduced
             through comparison with the A-gamma globin gene. Base substitutions
             in the initiation codon and in codons downstream, that create
             internal termination signals in exons 2 and 3, make this sequence a
             pseudogene.
              
                    Delta and beta genes
                    --------------------
              
             The delta and beta genes (denoted hbd and hbb below) are normally
             expressed in the adult: two alpha chains plus two beta chains
             constitute HbA, which in normal adult life comprises about 97% of
             the total hemoglobin.  Two alpha chains plus two delta chains
             constitute HbA-2, which with HbF comprises the remaining 3% of
             adult hemoglobin.
              
             The sequence given below has been reconstructed from the sequences
             reported by [47] and [62]: the mutation at base 62143 is apparently
             sufficient to distinguish the Kurdish Jew thalassemic sequence from
             a normal (consensus) beta globin DNA; [62] has resolved all
             sequence differences to date with exception of the differences
             reported herein as variations.
              
             The promoter region sequences 'ccaat', 'ata' and 'cttctg' found at
             bases 54672, 54709 and 54747 in the delta gene, and at bases 62061,
             62106 and 62144 in the beta gene, are characteristic of all
             beta-like genes, as well as of some other mammalian genes, and are
             thought to influence transcription and translation [27],[76].
             However, alternative cap sites have been found for these genes as
             well as other beta-like genes [58],[73].
              
             [95] describes the mutation (substitution of 'a' for 't' at
             position 62107, thereby destroying the promoter) found in an Hb
             Lepore-beta+ -thalassemia patient, who was homozygous for this
             mutation.  The father who had the simple beta-thalassemia trait was
             found to be heterozygous.
              
             A form of thalassemia exists, where 19 bp are added after the first
             exon, starting at position 62390 and ending at a stop codon at
             position 62406-62408 [30],[43],[57]. This aberrant splicing is
             caused by a mutation of 'g' to 'a' in the first intron of
             beta-hemoglobin at position 62388.  The substitution of a 'g' for a
             't' at position 62394 also causes premature splicing and results in
             an abnormal and abbreviated beta hemoglobin [90].
              
             Another form of beta-thalassemia is produced by the substitution of
             an 'a' for a 'g' at position 62632.  This causes a readthrough at
             the exon/intron boundary of exon 2/intron 2 [44].
              
             The Alu family sequences found at bases 50915, 51976, 65513 and
             66776 are again typical of the beta-like globin Alu's.  These
             sequences are of considerable interest in relation to regulation,
             recombination and transcription by RNA polymerase III.
              
             There are non-Alu repetitive elements in the gene cluster that have
             been partially characterized: the EC-1 repeat [38] and a
             retrovirus-like element in the 3' flank about 300 kb downstream of
             this sequence [75] (see separate entry); there are numerous repeats
             in the 5' flank which will be included in a future update [80].
             Reference [83] has characterized a novel KpnI family sequence in
             the 3' flank of the cluster.
              
             Potential polyadenylation signals were identified for the following
             genes:
                hbe       positions 21055-21060
                hbgg      positions 36043-36048
                hbga      positions 40959-40964
                hbd       positions 56365-56370
                hbb       positions 63718-63723.
 FEATURES             Location/Qualifiers
      misc_feature    19541..19632
                      /note="This feature applies to a gene which lacks a coding
                      region feature. "
                      /gene="HBE1"
                      /map="11p15.5"
      misc_feature    34531..34622
                      /note="This feature applies to a gene which lacks a coding
                      region feature. "
                      /gene="HBG2"
                      /map="11p15.5"
      misc_feature    39467..39558
                      /note="This feature applies to a gene which lacks a coding
                      region feature. "
                      /gene="HBG1"
                      /map="11p15.5"
      misc_feature    54790..54881
                      /note="This feature applies to a gene which lacks a coding
                      region feature. "
                      /gene="HBD"
                      /map="11p15.5"
      misc_feature    62187..62278
                      /note="This feature applies to a gene which lacks a coding
                      region feature. "
                      /gene="HBB"
                      /map="11p15.5"
      misc_feature    62279..62389
                      /note="This feature applies to a gene which lacks a coding
                      region feature. "
                      /gene="HBB thalassemia"
      exon            <19541..19632
                      /number=1
                      /gene="HBE1"
                      /map="11p15.5"
                      /note="epsilon-globin"
      exon            <34531..34622
                      /number=1
                      /gene="HBG2"
                      /map="11p15.5"
                      /note="G-gamma globin"
      exon            <39467..39558
                      /number=1
                      /gene="HBG1"
                      /map="11p15.5"
                      /note="A-gamma globin"
      exon            <54790..54881
                      /number=1
                      /gene="HBD"
                      /map="11p15.5"
                      /note="delta-globin"
      exon            <62187..62278
                      /number=1
                      /gene="HBB"
                      /map="11p15.5"
                      /note="beta-globin"
      exon            <62187..62278
                      /number=1
                      /note="beta-globin thalassemia, [30],[43]"
      exon            <45710..45800
                      /number=1
                      /note="pseudo-hbp, [72]"
      CDS             join(45710..45800,45922..46145,46997..47124)
                      /pseudo
                      /codon_start=1
                      /note="pseudo-hbp"
      repeat_region   10597..10611
                      /note="Alu flank repeat 5' copy"
      repeat_region   10612..10924
                      /note="Alu family repeat"
      repeat_region   10925..10939
                      /note="Alu flank repeat 3' copy"
      prim_transcript 19289..21080
                      /note="hbe mRNA (alt.) [23],[52],[60]"
      prim_transcript 19486..21080
                      /note="hbe mRNA (alt.) [23],[52],[60]"
      prim_transcript 19488..21080
                      /note="hbe mRNA (alt.) [23],[52],[60]"
      intron          19633..19754
                      /note="hbe intron 1 [23]"
      exon            19755..19977
                      /number=2
      intron          19978..20832
                      /note="hbe intron 2 [23]"
      exon            20833..>20961
                      /number=3
                      /note="epsilon-globin"
      variation       20983
                      /note="g in [76]; c in [23]"
      old_sequence    replace(21372..21378,"")
                      /citation=[76]
      unsure          31888..32020
                      /note="sequenced on one strand only [76]"
      repeat_region   32390..32406
                      /note="Alu flank repeat 5' copy [31]"
      repeat_region   32407..32711
                      /note="Alu family repeat [31]"
      variation       32608
                      /note="g in [29]; a in [31]"
      repeat_region   32712..32728
                      /note="Alu flank repeat 3' copy [31]"
      variation       32743..32744
                      /note="ag in [29]; ga in [31]"
      variation       33186
                      /note="a in [29]; g in [31]"
      variation       33198
                      /note="a in [29]; g in [31]"
      mutation        34276
                      /note="c in wt; g in persons with elevated gamma chain
                      [77]"
      mutation        34282
                      /note="c in wt; t in persons with elevated gamma chain
                      [77]"
      mutation        34321
                      /note="c in wt; t in high G-gamma SS; beta thalassemia;
                      and in low Hb F G-gamma-beta+-HPHF and HPFH [77]"
      mutation        34361
                      /note="g in wt; a in persons with elevated gamma chain
                      [77]"
      prim_transcript 34478..36069
                      /note="hbgg mRNA [15],[24],[27]"
      intron          34623..34744
                      /note="hbgg intron 1 [24]"
      exon            34745..34967
                      /number=2
      intron          34968..35853
                      /note="hbgg intron 2 [24]"
      exon            35854..>35982
                      /number=3
                      /note="G-gamma globin"
      conflict        replace(37504,"t")
                      /citation=[98]
                      /citation=[29]
      mutation        37657..40179
                      /note="g-25 kb-c in wt; gc in silent deletion [91]"
      variation       replace(37993,"t")
                      /citation=[98]
                      /citation=[29]
                      /note="t in all Benin-type sickle cell (beta-S)
                      chromosomes and some African beta-A chromosomes; t
                      abolishes a TaqI site"
      mutation        39297
                      /note="g in wt (b allele, see separate sequence); a in
                      HPFH [81],[82]"
      prim_transcript 39414..40985
                      /note="hbga mRNA [5],[15],[24],[27]"
      variation       39438
                      /note="a in [29]; g in [15]"
      intron          39559..39680
                      /note="hbga intron 1 [24]"
      exon            39681..39903
                      /number=2
      intron          39904..40769
                      /note="hbga intron 2 [17],[24]"
      exon            40770..>40898
                      /number=3
                      /note="A-gamma globin"
      variation       43782..43784
                      /note="gat in [94]; gt in [76]"
      variation       43830..43832
                      /note="ttg in [94]; tg in [76]"
      variation       43843
                      /note="t in [94]; c in [76]"
      variation       44122
                      /note="t in [94]; c in [76]"
      variation       45069..45077
                      /note="aaaaaaaaa in [94]; aa in [76]"
      variation       45227..45228
                      /note="ca in [94]; ctca in [76]"
      variation       45280
                      /note="t in [94]; c in [76]"
      variation       45297
                      /note="c in [94]; t in [76]"
      variation       45299
                      /note="t in [94]; c in [76]"
      variation       45309..45311
                      /note="cat in [94]; ct in [76]"
      variation       45317..45319
                      /note="tta in [94]; ta in [76]"
      variation       45321..45323
                      /note="tag in [94]; tg in [76]"
      mRNA            45657..47370
                      /note="pseudo-hbp mRNA [72]"
      intron          45801..45923
                      /note="pseudo-hbp intron 1 (no splice consensus at 45941
                      [17],[24],[72]; putative"
      exon            45922..46145
                      /pseudo
                      /number=2
                      /note="pseudo-hbp, [72]"
      intron          46146..46996
                      /note="pseudo-hbp intron 2 (no splice consensus at 46164
                      [72]; putative"
      exon            46997..>47124
                      /number=3
                      /note="pseudo-hbp, [72]"
      repeat_region   complement(50889..50894)
                      /note="Alu flank repeat 3' copy [47],[62]"
      repeat_region   complement(50915..51198)
                      /note="Alu family repeat [47],[62]"
      repeat_region   complement(51199..51204)
                      /note="Alu flank repeat 5' copy [47],[62]"
      repeat_region   51966..51975
                      /note="Alu flank repeat 5' copy [62]"
      repeat_region   51976..52259
                      /note="Alu family repeat [31],[62]"
      repeat_region   52286..52295
                      /note="Alu flank repeat 3' copy [62]"
      prim_transcript 54740..56389
                      /note="hbd mRNA [25]"
      intron          54882..55009
                      /note="hbd intron 1 [25]"
      mutation        54886
                      /note="g in wt; a in beta thalassemia [89]"
      exon            55010..55232
                      /number=2
      mutation        55047
                      /note="g in wt; t in beta-thalassemia Glu->stop"
      intron          55233..56130
                      /note="hbd intron 2 [25]"
      variation       55523
                      /note="ct in [54],[62],[76]; tc in [25]"
      variation       55571..55572
                      /note="ct in [62],[76]; c in [25]; cc in [54]"
      exon            56131..>56259
                      /number=3
                      /note="delta-globin"
      mutation        58855..63093
                      /note="a-4239 bp-c in wt; ac in atypical beta-thalassemia
                      [88]"
      mutation        59663..72286
                      /note="t-12622 bp-t in wt; tt in Dutch beta-0- thalassemia
                      [93]"
      variation       60745..60750
                      /note="tatttt in [62],[76]; t in [37]"
      variation       60832
                      /note="a in [37],[62],[76]; g in [51]"
      variation       60842
                      /note="c in [62],[76]; ca in [37],[51]"
      variation       61148
                      /note="c in [51],[62],[76]; g in [51]"
      variation       61294
                      /note="c in [62],[76]; t in [51]"
      variation       61308
                      /note="t in [62],[76]; tt in [51]"
      allele          61586
                      /note="t in wt; c in Albanian allele (produces RsaI site)
                      [70]"
      allele          61608..61609
                      /note="tt in wt; tatat in Albanian allele [70]"
      variation       61663
                      /note="a in [62],[76]; g in [51]"
      variation       61753
                      /note="gc in [62],[76]; g in [51]"
      variation       61773
                      /note="g in [62]; a in [76]"
      variation       61797
                      /note="t in [54],[62],[76]; c in [51]"
      variation       61824
                      /note="g in [62],[76]; c in [51]"
      variation       61922
                      /note="g in [51],[62],[76]; c in [41]"
      variation       61932
                      /note="a in [51],[62],[76]; t in [41]"
      mutation        62050
                      /note="c in wt; g in beta-thalassemia [63]"
      mutation        62107
                      /note="t in normal promoter; a in thalassemia patient (Hb
                      Lepore-beta+ -thal)"
      mutation        62109
                      /note="a in [26],[41],[51]; c in [62],[76],[J. Biol. C"
      prim_transcript 62137..63742
                      /note="hbb mRNA [5],[11],[10],[7],[26]"
      variation       62156
                      /note="c in [62],[76]; t in [48]"
      variation       62195
                      /note="c in [26],[62],[76]; t in [48]"
      mutation        62205..62207
                      /note="gag in wt; gg in beta-thalassemia [64]"
      mutation        62206
                      /note="a in normal hbb; t in sickle cell anemia 78]"
      mutation        62238
                      /note="a in wt; t in thalassemia [Ann. N.Y. Acad. Sci.
                      344, 113-119 (1980)]"
      intron          62279..62408
                      /note="hbb intron 1 [10],[26],[54]"
      mutation        62279
                      /note="g in wt; a in thalassemia [63]"
      intron          62279..62389
                      /gene="HBB thalassemia"
      mutation        62283
                      /note="g in wt; c in thalassemia [63]"
      mutation        62284
                      /note="t in wt; c in thalassemia [63]"
      mutation        62388
                      /note="g in wt; a in thalassemia [30],[43],[57],[90]"
      exon            62390..>62408
                      /number=2
                      /note="beta-globin thalassemia, [30],[43]"
      mutation        62394
                      /note="t in wt; g in thalassemia [90]"
      exon            62409..62631
                      /number=2
      mutation        62430
                      /note="g in wt; a in a form of thalassemia [30]"
      intron          62632..63481
                      /note="hbb intron 2 [10],[12],[26]"
      mutation        62632
                      /note="g in wt; a in a form of thalassemia [44]"
      variation       62647
                      /note="c in [26],[48],[62],[76]; g in [48]"
      variation       62705
                      /note="g in [26],[62],[76]; t in [48]"
      variation       62712
                      /note="c in [26],[62],[76]; t in [48]"
      variation       63297
                      /note="t in [26],[48],[62],[76]; c in [48]"
      mutation        63376
                      /note="c in wt; g thalassemia [63] (causes an extra exon)"
      exon            63482..>63610
                      /number=3
                      /note="beta-globin"
      variation       63830..63831
                      /note="ta in [62],[76]; t in [26]"
      mutation        63918..63919
                      /note="ct in wt; cct in a form of thalassemia [45]"
      variation       63918
                      /note="c in [62],[76]; cc in [26]"
      mutation        63957..63958
                      /note="tt in wt; aa in a form of thalassemia [45]"
      variation       63957..63958
                      /note="aa in [37],[62],[76]; tt in [26]"
      variation       63974
                      /note="g in [37],[62],[76]; c in [26]"
      repeat_region   65490..65502
                      /note="Alu flank repeat 5' copy [62],[76]"
      repeat_region   65513..65767
                      /note="Alu family repeat [62],[76]"
      repeat_region   65768..65780
                      /note="Alu flank repeat 3' copy [62],[76]"
      repeat_region   66765..66775
                      /note="Alu flank repeat 5' copy [62],[76]"
      repeat_region   66776..67042
                      /note="Alu family repeat [62],[76]"
      repeat_region   67069..67079
                      /note="Alu flank repeat 3' copy [62],[76]"
      repeat_region   67071..73195
                      /note="KpnI family repeat [83]"
      repeat_unit     complement(16918..17218)
                      /rpt_family="Alu"
      repeat_unit     17940..18231
                      /rpt_family="Alu"
      CDS             join(19541..19632,19755..19977,20833..20961)
                      /note="epsilon-globin"
                      /codon_start=1
                      /translation="MVHFTAEEKAAVTSLWSKMNVEEAGGEALGRLLVVYPWTQRFFD
                      SFGNLSSPSAILGNPKVKAHGKKVLTSFGDAIKNMDNLKPAFAKLSELHCDKLHVDPE
                      NFKLLGNVMVIILATHFGKEFTPEVQAAWQKLVSAVAIALAHKYH"
      CDS             join(34531..34622,34745..34967,35854..35982)
                      /note="G-gamma globin"
                      /codon_start=1
                      /translation="MGHFTEEDKATITSLWGKVNVEDAGGETLGRLLVVYPWTQRFFD
                      SFGNLSSASAIMGNPKVKAHGKKVLTSLGDAIKHLDDLKGTFAQLSELHCDKLHVDPE
                      NFKLLGNVLVTVLAIHFGKEFTPEVQASWQKMVTGVASALSSRYH"
      CDS             join(39467..39558,39681..39903,40770..40898)
                      /note="A-gamma globin"
                      /codon_start=1
                      /translation="MGHFTEEDKATITSLWGKVNVEDAGGETLGRLLVVYPWTQRFFD
                      SFGNLSSASAIMGNPKVKAHGKKVLTSLGDAIKHLDDLKGTFAQLSELHCDKLHVDPE
                      NFKLLGNVLVTVLAIHFGKEFTPEVQASWQKMVTAVASALSSRYH"
      CDS             join(54790..54881,55010..55232,56131..56259)
                      /note="delta-globin"
                      /codon_start=1
                      /translation="MVHLTPEEKTAVNALWGKVNVDAVGGEALGRLLVVYPWTQRFFE
                      SFGDLSSPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFSQLSELHCDKLHVDPE
                      NFRLLGNVLVCVLARNFGKEFTPQMQAAYQKVVAGVANALAHKYH"
      CDS             join(62187..62278,62409..62631,63482..63610)
                      /note="beta-globin"
                      /codon_start=1
                      /translation="MVHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFE
                      SFGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPE
                      NFRLLGNVLVCVLAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH"
      CDS             join(62187..62278,62390..62408)
                      /note="beta-globin thalassemia"
                      /codon_start=1
                      /translation="MVHLTPEEKSAVTALWGKVNVDEVGGEALGSLFSHP"
 BASE COUNT    22068 a  14146 c  14785 g  22309 t
 ORIGIN      1 bp upstream of EcoRI site; chromosome 11p15 [J. Biol. Chem. 260]
         1 gaattctaat ctccctctca accctacagt cacccatttg gtatattaaa gatgtgttgt
        61 ctactgtcta gtatccctca agtagtgtca ggaattagtc atttaaatag tctgcaagcc
       121 aggagtggtg gctcatgtct gtaattccag cactggagag gtagaagtgg gaggactgct
       181 tgagctcaag agtttgatat tatcctggac aacatagcaa gacctcgtct ctacttaaaa
       241 aaaaaaaaat tagccaggca tgtgatgtac acctgtagtc ccagctactc aggaggccga
       301 aatgggagga tcccttgagc tcaggaggtc aaggctgcag tgagacatga tcttgccact
       361 gcactccagc ctggacagca gagtgaaacc ttgcctcacg aaacagaata caaaaacaaa
       421 caaacaaaaa actgctccgc aatgcgcttc cttgatgctc taccacatag gtctgggtac
       481 tttgtacaca ttatctcatt gctgttcgta attgttagat taattttgta atattgatat
       541 tattcctaga aagctgaggc ctcaagatga taacttttat tttctggact tgtaatagct
       601 ttctcttgta ttcaccatgt tgtaactttc ttagagtagt aacaatataa agttattgtg
       661 agtttttgca aacacagcaa acacaacgac ccatatagac attgatgtga aattgtctat
       721 tgtcaattta tgggaaaaca agtatgtact ttttctacta agccattgaa acaggaataa
       781 cagaacaaga ttgaaagaat acattttccg aaattacttg agtattatac aaagacaagc
       841 acgtggacct gggaggaggg ttattgtcca tgactggtgt gtggagacaa atgcaggttt
       901 ataatagatg ggatggcatc tagcgcaatg actttgccat cacttttaga gagctcttgg
       961 ggaccccagt acacaagagg ggacgcaggg tatatgtaga catctcattc tttttcttag
      1021 tgtgagaata agaatagcca tgacctgagt ttatagacaa tgagcccttt tctctctccc
      1081 actcagcagc tatgagatgg cttgccctgc ctctctacta ggctgactca ctccaaggcc
      1141 cagcaatggg cagggctctg tcagggcttt gatagcacta tctgcagagc cagggccgag
      1201 aaggggtgga ctccagagac tctccctccc attcccgagc agggtttgct tatttatgca
      1261 tttaaatgat atatttattt taaaagaaat aacaggagac tgcccagccc tggctgtgac
      1321 atggaaacta tgtagaatat tttgggttcc attttttttt ccttctttca gttagaggaa
      1381 aaggggctca ctgcacatac actagacaga aagtcaggag ctttgaatcc aagcctgatc
      1441 atttccatgt catactgaga aagtccccac ccttctctga gcctcagttt ctctttttat
      1501 aagtaggagt ctggagtaaa tgatttccaa tggctctcat ttcaatacaa aatttccgtt
      1561 tattaaatgc atgagcttct gttactccaa gactgagaag gaaattgaac ctgagactca
      1621 ttgactggca agatgtcccc agaggctctc attcagcaat aaaattctca ccttcaccca
      1681 ggcccactga gtgtcagatt tgcatgcact agttcacgtg tgtaaaaagg aggatgcttc
      1741 tttcctttgt attctcacat acctttagga aagaacttag cacccttccc acacagccat
      1801 cccaataact catttcagtg actcaaccct tgactttata aaagtcttgg gcagtataga
      1861 gcagagatta agagtacaga tgctggagcc agaccacctg agtgattagt gactcagttt
      1921 ctcttagtaa ttgtatgact cagtttcttc atctgtaaaa tggagggttt tttaattagt
      1981 ttgtttttga gaaagggtct cactctgtca cccaaatggg agtgtagtgg caaaatctcg
      2041 gctcactgca acttgcactt cccaggctca agcggtcctc ccacctcaac atcctgagta
      2101 gctggaacca caggtacaca ccaccatacc tcgctaattt tttgtatttt tggtagagat
      2161 ggggtttcac atgttacaca ggatggtctc agactccgga gctcaagcaa tctgcccacc
      2221 tcagccttcc aaagtgctgg gattataagc atgattacag gagttttaac aggctcataa
      2281 gattgttctg cagcccgagt gagttaatac atgcaaagag tttaaagcag tgacttataa
      2341 atgctaacta ctctagaaat gtttgctagt attttttgtt taactgcaat cattcttgct
      2401 gcaggtgaaa actagtgttc tgtactttat gcccattcat ctttaactgt aataataaaa
      2461 ataactgaca tttattgaag gctatcagag actgtaatta gtgctttgca taattaatca
      2521 tatttaatac tcttggattc tttcaggtag atactattat tatccccatt ttactacagt
      2581 taaaaaaact acctctcaac ttgctcaagc atacactctc acacacacaa acataaacta
      2641 ctagcaaata gtagaattga gatttggtcc taattatgtc tttgctcact atccaataaa
      2701 tatttattga catgtacttc ttggcagtct gtatgctgga tgctggggat acaaagatgt
      2761 ttaaatttaa gctccagtct ctgcttccaa aggcctccca ggccaagtta tccattcaga
      2821 aagcattttt tactctttgc attccactgt ttttcctaag tgactaaaaa attacacttt
      2881 attcgtctgt gtcctgctct gggatgatag tctgactttc ctaacctgag cctaacatcc
      2941 ctgacatcag gaaagactac accatgtgga gaaggggtgg tggttttgat tgctgctgtc
      3001 ttcagttaga tggttaactt tgtgaagttg aaaactgtgg ctctctggtt gactgttaga
      3061 gttctggcac ttgtcactat gcctattatt taacaaatgc atgaatgctt cagaatatgg
      3121 gaatattatc ttctggaata gggaatcaag ttatattatg taacccagga ttagaagatt
      3181 cttctgtgtg taagaatttc ataaacatta agctgtctag caaaagcaag ggcttggaaa
      3241 atctgtgagc tcctcaccat atagaaagct tttaacccat cattgaataa atccctatag
      3301 gggatttcta ccctgagcaa aaggctggtc ttgattaatt cccaaactca tatagctctg
      3361 agaaagtcta tgctgttaac gttttcttgt ctgctacccc atcatatgca caacaataaa
      3421 tgcaggccta ggcatgactg aaggctctct cataattctt ggttgcatga atcagattat
      3481 caacagaaat gttgagacaa actatgggga agcagggtat gaaagagctc tgaatgaaat
      3541 ggaaaccgca atgcttcctg cccattcagg gctccagcat gtagaaatct ggggctttgt
      3601 gaagactggc ttaaaatcag aagccccatt ggataagagt agggaagaac ctagagccta
      3661 cgctgagcag gtttccttca tgtgacaggg agcctcctgc cccgaacttc cagggatcct
      3721 ctcttaagtg tttcctgctg gaatctcctc acttctatct ggaaatggtt tctccacagt
      3781 ccagcccctg gctagttgaa agagttaccc atgcagaggc cctcctagca tccagagact
      3841 agtgcttaga ttcctacttt cagcgttgga caacctggat ccacttgccc agtgttcttc
      3901 cttagttcct accttcgacc ttgatcctcc tttatcttcc tgaaccctgc tgagatgatc
      3961 tatgtgggga gaatggcttc tttgagaaac atcttcttcg ttagtggcct gcccctcatt
      4021 cccactttaa tatccagaat cactataaga agaatataat aagaggaata actcttatta
      4081 taggtaaggg aaaattaaga ggcatacgtg atgggatgag taagagagga gagggaagga
      4141 ttaatggatg ataaaatcta ctactatttg ttgagacctt ttatagtcta atcaattttg
      4201 ctattgtttt ccatcctcac gctaactcca taaaaaaaca ctattattat ctttattttg
      4261 ccatgacaag actgagctca gaagagtcaa gcatttgcct aaggtcggac atgtcagagg
      4321 cagtgccaga cctatgtgag actctgcagc tactgctcat gggccctgtg ctgcactgat
      4381 gaggaggatc agatggatgg ggcaatgaag caaaggaatc attctgtgga taaaggagac
      4441 agccatgaag aagtctatga ctgtaaattt gggagcagga gtctctaagg acttggattt
      4501 caaggaattt tgactcagca aacacaagac cctcacggtg actttgcgag ctggtgtgcc
      4561 agatgtgtct atcagaggtt ccagggaggg tggggtgggg tcagggctgg ccaccagcta
      4621 tcagggccca gatgggttat aggctggcag gctcagatag gtggttaggt caggttggtg
      4681 gtgctgggtg gagtccatga ctcccaggag ccaggagaga tagaccatga gtagagggca
      4741 gacatgggaa aggtggggga ggcacagcat agcagcattt ttcattctac tactacatgg
      4801 gactgctccc ctataccccc agctaggggc aagtgccttg actcctatgt tttcaggatc
      4861 atcatctata aagtaagagt aataattgtg tctatctcat agggttatta tgaggatcaa
      4921 aggagatgca cactctctgg accagtggcc taacagttca ggacagagct atgggcttcc
      4981 tatgtatggg tcagtggtct caatgtagca ggcaagttcc agaagatagc atcaaccact
      5041 gttagagata tactgccagt ctcagagcct gatgttaatt tagcaatggg ctgggaccct
      5101 cctccagtag aaccttctaa ccagctgctg cagtcaaagt cgaatgcagc tggttagact
      5161 ttttttaatg aaagcttagc tttcattaaa gattaagctc ctaagcaggg cacagatgaa
      5221 attgtctaac agcaactttg ccatctaaaa aaatctgact tcactggaaa catggaagcc
      5281 caaggttctg aacatgagaa atttttagga atctgcacag gagttgagag ggaaacaaga
      5341 tggtgaaggg actagaaacc acatgagaga cacgaggaaa tagtgtagat ttaggctgga
      5401 ggtaaatgaa agagaagtgg gaattaatac ttactgaaat ctttctatat gtcaggtgcc
      5461 attttatgat atttaataat ctcattacat atggtaattc tgtgagatat gtattattga
      5521 acatactata attaatacta atgataagta acacctcttg agtacttagt atatgctaga
      5581 atcaaattta agtttatcat atgaggccgg gcacggtggc tcatatatgg gattacatgc
      5641 ctgtaatccc agcactttgg gaggccaagg caattggatc acctgaggtc aggagttcca
      5701 gaccagcctg gccaacatgg tgaaacccct tctctactaa aaaatacaaa aaatcagcca
      5761 ggtgtggtgg cacgcgtcta taatcccagc tactcaggag gctgaggcag gagaatcact
      5821 tgaacccagg aggtggaggt tgcagtgagc taagattgca ccactgcact ccagcctagg
      5881 cgacagagtg agactccatc tcaaaaaaaa aaaaagaagt ttattatatg aattaactta
      5941 gttttactca caccaatact cagaagtaga ttattacctc atttattgat gaggagccca
      6001 atgtacttgt agtgtagatc aacttattga aagcacaagc taataagtag acaattagta
      6061 attagaagtc agatggtctg agctctccta ctgtctacat tacatgagct cttattaact
      6121 ggggactcga aaatcaaaga catgaaataa tttgtccaag cttacagaac caccaagtag
      6181 taaggctagg atgtagaccc agttctgcta cctctgaaga cagtgttttt tccacagcaa
      6241 aacacaaact cagatattgt ggatgcgaga aattagaagt agatattcct gccctgtggc
      6301 ccttgcttct tacttttact tcttggcgat tggaagttgt ggtccaagcc acagttgcag
      6361 accatacttc ctcaaccata attgcatttc ttcaggaaag tttgagggag aaaaaggtaa
      6421 agaaaaattt agaaacaact tcagaataaa gagattttct cttgggttac agagattgtc
      6481 atatgacaaa ttataagcag acacttgaga aaactgaagg cccatgcctg cccaaattac
      6541 cctttgaccc cttggtcaag ctgcaacttt ggttaaaggg agtgtttatg tgttatagtg
      6601 ttcatttact cttctggtct aacccattgg ctccgtcttc atcctgcagt gacctcagtg
      6661 cctcagaaac atacatatgt ttgtctagtt taagtttgtg tgaaattcta actagcgtca
      6721 agaactgagg gccctaaact atgctaggaa tagtgctgtg gtgctgtgat aggtacacaa
      6781 gaaatgagaa gaaactgcag attctctgca tctccctttg ccgggtctga caacaaagtt
      6841 tccccaaatt ttaccaatgc aagccatttc tccatatgct aactacttta aaatcatttg
      6901 gggcttcaca ttgtctttct catctgtaaa aagaatggaa gaactcattc ctacagaact
      6961 ccctatgtct tccctgatgg gctagagttc ctctttctca aaaattagcc attattgtat
      7021 ttccttctaa gccaaagctc agaggtcttg tattgcccag tgacatgcac actggtcaaa
      7081 agtaggctaa gtagaagggt actttcacag gaacagagag caaaagaggt gggtgaatga
      7141 gagggtaagt gagaaaagac aaatgagaag ttacaacatg atggcttgtt gtctaaatat
      7201 ctcctaggga attattgtga gaggtctgaa tagtgttgta aaataagctg aatctgctgc
      7261 ctaacattaa cagtcaagaa atacctccga ataactgtac ctccaattat tctttaaggt
      7321 agcatgcaac tgtaatagtt gcatgtatat atttatcata atactgtaac agaaaacact
      7381 tactgaatat atactgtgtc cctagttctt tacacaataa actaatctca tcctcataat
      7441 tctattagct aatacatatt atcatcctat atttcagaga cttcaagaag ttaagcaact
      7501 tgctcaagat catctaagaa gtaggtggta tttctgggct catttggccc ctcctaatct
      7561 ctcatggcaa catggctgcc taaagtgttg attgccttaa ttcatcaggg atgggctcat
      7621 actcactgca gaccttaact ggcatcctct tttcttatgt gatctgcctg accctagtag
      7681 aacttatgaa atttctgatg agaaaggaga gaggagaaag gcagagctga ctgtgatgag
      7741 tgatgaaggt gccttctcat ctgggtacca gtggggcctc taagactaag tcactctgtc
      7801 tcactgtgtc ttagccagtt ccttacagct tgccctgatg ggagatagag aatgggtatc
      7861 ctccaacaaa aaaataaatt ttcatttctc aaggtccaac ttatgttttc ttaattttta
      7921 aaaaaatctt gaccattctc cactctctaa aataatccac agtgagagaa acattctttt
      7981 cccccatccc ataaatacct ctattaaata tggaaaatct gggcatggtg tctcacacct
      8041 gtaatcccag cactttggga ggctgaggtg ggtggactgc ttggagctca ggagttcaag
      8101 accatcttgg acaacatggt gataccctgc ctctacaaaa agtacaaaaa ttagcctggc
      8161 atggtggtgt gcacctgtaa tcccagctat tagggtggct gaggcaggag aattgcttga
      8221 acccgggagg cggaggttgc agtgagctga gatcgtgcca ctgcactcca gcctggggga
      8281 cagagcacat tataattaac tgttattttt tacttggact cttgtgggga ataagataca
      8341 tgttttattc ttatttatga ttcaagcact gaaaatagtg tttagcatcc agcaggtgct
      8401 tcaaaaccat ttgctgaatg attactatac tttttacaag ctcagctccc tctatccctt
      8461 ccagcatcct catctctgat taaataagct tcagtttttc cttagttcct gttacatttc
      8521 tgtgtgtctc cattagtgac ctcccatagt ccaagcatga gcagttctgg ccaggcccct
      8581 gtcggggtca gtgccccacc cccgccttct ggttctgtgt aaccttctaa gcaaaccttc
      8641 tggctcaagc acagcaatgc tgagtcatga tgagtcatgc tgaggcttag ggtgtgtgcc
      8701 cagatgttct cagcctagag tgatgactcc tatctgggtc cccagcagga tgcttacagg
      8761 gcagatggca aaaaaaagga gaagctgacc acctgactaa aactccacct caaacggcat
      8821 cataaagaaa atggatgcct gagacagaat gtgacatatt ctagaatata ttatttcctg
      8881 aatatatata tatatatata tacacatata cgtatatata tatatatata tatatttgtt
      8941 gttatcaatt gccatagaat gattagttat tgtgaatcaa atatttatct tgcaggtggc
      9001 ctctatacct agaagcggca gaatcaggct ttattaatac atgtgtatag atttttagga
      9061 tctatacaca tgtattaata tgaaacaagg atatggaaga ggaaggcatg aaaacaggaa
      9121 aagaaaacaa accttgtttg ccattttaag gcacccctgg acagctaggt ggcaaaaggc
      9181 ctgtgctgtt agaggacaca tgctcacata cggggtcaga tctgacttgg ggtgctactg
      9241 ggaagctctc atcttaagga tacatctcag gccagtcttg gtgcattagg aagatgtagg
      9301 caactctgat cctgagagga aagaaacatt cctccaggag agctaaaagg gttcacctgt
      9361 gtgggtaact gtgaaggact acaagaggat gaaaaacaat gacagacaga cataatgctt
      9421 gtgggagaaa aaacaggagg tcaaggggat agagaaggct tccagaagaa tggctttgaa
      9481 gctggcttct gtaggagttc acagtggcaa agatgtttca gaaatgtgac atgacttaag
      9541 gaactataca aaaaggaaca aatttaagga gaggcagata aattagttca acagacatgc
      9601 aaggaatttt cagatgaatg ttatgtctcc actgagcttc ttgaggttag cagctgtgag
      9661 ggttttgcag gcccaggacc cattacagga cctcacgtat acttgacact gttttttgta
      9721 ttcatttgtg aatgaatgac ctcttgtcag tctactcggt ttcgctgtga atgaatgatg
      9781 tcttgtcagc ctacttggtt tcgctaagag cacagagaga agatttagtg atgctatgta
      9841 aaaacttcct ttttggttca agtgtatgtt tgtgatagaa atgaagacag gctacatgat
      9901 gcatatctaa cataaacaca aacattaaga aaggaaatca acctgaagag tatttataca
      9961 gataacaaaa tacagagagt gagttaaatg tgtaataact gtggcacagg ctggaatatg
     10021 agccatttaa atcacaaatt aattagaaaa aaaacagtgg ggaaaaaatt ccatggatgg
     10081 gtctagaaag actagcattg ttttaggttg agtggcagtg tttaaagggt gatatcagac
     10141 taaacttgaa atatgtggct aaataactag aatactcttt attttttcgt atcatgaata
     10201 gcagatatag cttgatggcc ccatgcttgg tttaacatcc ttgctgttcc tgacatgaaa
     10261 tccttaattt ttgacaaagg ggctattcat tttcatttta tattgggcct agaaattatg
     10321 tagatggtcc tgaggaaaag tttatagctt gtctatttct ctctctaaca tagttgtcag
     10381 cacaatgcct aggctatagg aagtactcaa agcttgttaa attgaattct atccttctta
     10441 ttcaattcta cacatggagg aaaaactcat cagggatgga ggcacgcctc taaggaaggc
     10501 aggtgtggct ctgcagtgtg attgggtact tgcaggacga agggtggggt gggagtggct
     10561 aaccttccat tcctagtgca gaggtcacag cctaaacatc aaattccttg aggtgcggtg
     10621 gctcactcct gtaatcacag cagtttggga cgccaaggtg ggcagatcac ttgaggtcag
     10681 gagttggaca ccagcccagc caacatagtg aaacctggtc tctgcttaaa aatataaaaa
     10741 ttagctggac gtggtgacgg gagcctgtaa tccaactact tgggaggctg aggcaggaga
     10801 atcgcttgaa ccggggaggt ggagtttgca ctgagcagag atcatgccat tgcactccag
     10861 cctccagagc gagactctgt ctaaagaaaa acgaaaacaa acaaacaaac aaacaaacaa
     10921 aacccatcaa attccctgac cgaacagaat tctgtctgat tgttctctga cttatctacc
     10981 attttccctc cttaaagaaa ctgtggaact tccttcagct agaggggcct ggctcagaag
     11041 cctctggtca gcatccaaga aatacttgat gtcactttgg ctaaaggtat gatgtgtaga
     11101 caagctccag agatggtttc tcatttccat atccacccac ccagctttcc aattttaaag
     11161 ccaattctga ggtagagact gtgatgaaca aacaccttga caaaattcaa cccaaagact
     11221 cactttgcct agcttcaaaa tccttactct gacatatact cacagccaga aattagcatg
     11281 cactagagtg tgcatgagtg caacacacac acacaccaat tccatattct ctgtcagaaa
     11341 atcctgttgg tttttcgtga aaggatgttt tcagaggctg accccttgcc ttcacctcca
     11401 atgctaccac tctggtctaa gtcactgtca ccaccaccta aattatagct gttgactcat
     11461 aacaatcttc ctgcttctac cactgcccca ctacaatttc ttcccaatat actatccaaa
     11521 ttagtctttt caaaatgtaa gtcatatatg gtcacctctt tgttcaaagt cttctgatag
     11581 tttcctatat catttataat aaaaccaaat ccttacaatt ctctacaata gttgttcatg
     11641 catatattat gtttattaca gatacgcata tatatagctc tcatataaat aaatatatat
     11701 atttatgtgt atgtgtgtag agtgtttttt cttacaactc tatgatgtag gtattattag
     11761 tgtcccaaat tttataattt aggacttcta tgatctcatc ttttattctc cccttcaccg
     11821 aatctcatcc tacattggcc ttattgatat tccttgaaaa ttctaagcat cttacatctt
     11881 tagggtattt acatttgcca ttccctatgc cctaaatatt taatcatagt ttcatataaa
     11941 tgggttcctc atcatctatg ggtactctct caggtgttaa ctttatagtg aggactttcc
     12001 tgccatacta cttaaagtag cgataccctt tcaccctgtc ctaatcacac tctggccttc
     12061 atttcagttt tttttttttc tccatagcac ctaatctcat tggtatataa catgtttcat
     12121 ttgcttattt aatgtcaagc tctttccact atcaagtcca tgaaaacagg aactttattc
     12181 ctctattctg tttttgtgct gtattcttag caattttaca attttgaatg aaatgaatga
     12241 gcagtcaaac acatatacaa ctataattaa aaggatgtat gctgacacat ccactgctat
     12301 gcacacacaa agaaatcagt ggagtagagc tggaagcgct aagcctgcat agagctagtt
     12361 agccctccgc aggcagagcc ttgatgggat tactgagttc tagaattgga ctcatttgtt
     12421 ttgtaggctg agatttgctc ttgaaaactt gttctgacca aaataaaagg ctcaaaagat
     12481 gaatatcgaa accagggtgt tttttacact ggaatttata actagagcac tcatgtttat
     12541 gtaagcaatt aattgtttca tcagtcaggt aaaagtaaag aaaaactgtg ccaaggcagg
     12601 tagcctaatg caatatgcca ctaaagtaaa cattattcca taggtgtcag atatggctta
     12661 ttcatccatc ttcatgggaa ggatggcctt ggcctggaca tcagtgttat gtgaggttca
     12721 aaacacctct aggctataag gcaacagagc tccttttttt tttttctgtg ctttcctggc
     12781 tgtccaaatc tctaatgata agcatacttc tattcaatga gaatattctg taagattata
     12841 gttaagaatt gtgggagcca ttccgtctct tatagttaaa tttgagcttc ttttatgatc
     12901 actgtttttt taatatgctt taagttctgg ggtacatgtg ccatggtggt ttgctgcacc
     12961 catcaacccg tcatctacat taggtatttc tcctaatgct atccttcccc tagcccccca
     13021 cccccaacag gccccagtgt gtgatgttcc cctccctgtg tccatggatc actggttttt
     13081 tttttttttt tttttttttt tttaaagtct cagttaaatt tttggaatgt aatttatttt
     13141 cctggtatcc taggacctgc aagttatctg gtcactttag ccctcacgtt ttgatgataa
     13201 tcacatattt gtaaacacaa cacacacaca cacacacaca cacatatata tatataaaac
     13261 atatatatac ataaacacac ataacatatt tatcgggcat ttctgagcaa ctaactcatg
     13321 caggactctc aaacactaac ctatagcctt ttctatgtat ctacttgtgt agaaaccaag
     13381 cgtggggact gagaaggcaa tagcaggagc attctgactc tcactgcctt tggctaggtc
     13441 cctccctcat cacagctcag catagtccga gctcttatct atatccacac acagtttctg
     13501 acgctgccca gctatcacca tcccaagtct aaagaaaaaa ataatgggtt tgcccatctc
     13561 tgttgattag aaaacaaaac aaaataaaat aagcccctaa gctcccagaa aacatgacta
     13621 aaccagcaag aagaagaaaa tacaataggt atatgaggag actggtgaca ctagtgtctg
     13681 aatgaggctt gagtacagaa aagaggctct agcagcatag tggtttagag gagatgtttc
     13741 tttccttcac agatgcctta gcctcaataa gcttgcggtt gtggaagttt actttcagaa
     13801 caaactcctg tggggctaga attattgatg gctaaaagaa gcccggggga gggaaaaatc
     13861 attcagcatc ctcaccctta gtgacacaaa acagaggggg cctggttttc catatttcct
     13921 catgatggat gatctcgtta atgaaggtgg tctgacgaga tcattgcttc ttccatttaa
     13981 gccttgctca cttgccaatc ctcagtttta accttctcca gagaaataca cattttttat
     14041 tcaggaaaca tactatgtta tagtttcaat actaaataat caaagtactg aagatagcat
     14101 gcataggcaa gaaaaagtcc ttagctttat gttgctgttg tttcagaatt taaaaaagat
     14161 caccaagtca aggacttctc agttctagca ctagaggtgg aatcttagca tataatcaga
     14221 ggtttttcaa aatttctaga catgagattc aaagccctgc acttaaaata gtctcatttg
     14281 aattaactct ttatataaat tgaaagcaca ttctgaacta cttcagagta ttgttttatt
     14341 tctatgttct tagttcataa atacattagg caatgcaatt taattaaaaa aacccaagaa
     14401 tttcttagaa ttttaatcat gaaaataaat gaaggcatct ttacttactc aaggtcccaa
     14461 aaggtcaaag aaaccaggaa agtaaagcta tatttcagcg gaaaatggga tatttatgag
     14521 ttttctaagt tgacagactc aagttttaac cttcagtgcc catgatgtag gaaagtgtgg
     14581 cataactggc tgattctggc tttctactcc tttttcccat taaagatccc tcctgcttaa
     14641 ttaacattca caagtaactc tggttgtact ttaggcacag tggctcccga ggtcagtcac
     14701 acaataggat gtctgtgctc caagttgcca gagagagaga ttactcttga gaatgagcct
     14761 cagccctggc tcaaactcac ctgcaaactt cgtgagagat gaggcagagg tacactacga
     14821 aagcaacagt tagaagctaa atgatgagaa cacatggact catagaggga aacaacgcat
     14881 actggggcct atcagagggt ggagggtgag agaaggagag gatcaggaaa aatcactaat
     14941 ggatgctaag cgtaatacct gagtgatgag atcatctata caacaaaccc ccttgacatt
     15001 catttatcta tgtaacaaac ctgcacatcc tgtacacgta cccctgaact taaaataaaa
     15061 gttgaaaaca agaaagcaac agtttgaaca cttgttatgg tctattctct cattctttac
     15121 aattacacta gaaaatagcc acaggctcct gcaaggcagc cacagaattt atgacttgtg
     15181 atatccaagt cattcctgga taatgcaaaa tctaacacaa aatctagtag aatcatttgc
     15241 ttacatctat ttttgttctg agaatataga tttagataca taatggaagc agaataattt
     15301 aaaatctggc taatttagaa tcctaagcag ctcttttcct atcagtggtt tacaagcctt
     15361 gtttatattt ttcctatttt aaaaataaaa ataaagtaag ttatttgtgg taaagaatat
     15421 tcattaaagt atttatttct tagataatac catgaaaaac attcagtgaa gtgaagggcc
     15481 tactttaccc aacaagaatc taatttatat aatttttcat actaatagca tctaagaaca
     15541 gtacaatatt tgactcttca ggttaaacat atgtcataaa ttagccagaa agatttaaga
     15601 aaatattgga tgtttccttg tttaaattag gcatcttaca gtttttagaa tcctgcatag
     15661 aacttaagaa attacaaatg ctaaagcaaa cccaaacagg caggaattaa tcttcatcga
     15721 atttgggtgt ttctttctaa aagtccttta tacttaaatg tcttaagaca tacatagatt
     15781 ttattttact aattttaatt atacagacaa taaatgaata ttcttactga ttactttttc
     15841 tgactgtcta atctttctga tctatcctgg atggccataa cacttatctc tctgaacttt
     15901 gggcttttaa tataggaaag aaaagcaata atccattttt catggtatct catatgataa
     15961 acaaataaaa tgcttaaaaa tgagcaggtg aagcaattta tcttgaacca acaagcatcg
     16021 aagcaataat gagactgccc gcagcctacc tgacttctga gtcaggattt ataagccttg
     16081 ttactgagac acaaacctgg gcctttcaat gctataacct ttcttgaagc tcctccctac
     16141 cacctttagc cataaggaaa catggaatgg gtcagatccc tggatgcaag ccaggtctgg
     16201 aaccataggc agtaaggaga gaagaaaatg tgggctctgc aactggctcc gagggagcag
     16261 gagagaatca accccatact ctgaatctaa gagaagactg gtgtccatac tctgaatggg
     16321 aagaatgatg ggattaccca tagggcttgt tttagggaga aacctgttct ccaaactctt
     16381 ggccttgaga tacctggtcc ttattccttg gactttggca atgtctgacc ctcacattca
     16441 agttctgagg aagggccact gccttcatac tgtggatctg tagcaaattc cccctgaaaa
     16501 cccagagctg tatcttaatt gtttaaaaaa attatattat ctcaaggact gttcttctct
     16561 gagtagccaa gctcagcttg gttcaagcta caagcagctg agctgctttt tgtctagtca
     16621 ttgttctttt atttcagtgg atcaaatacg ttctttccaa acctaggatc ttgtcttcct
     16681 aggctatata ttttgtccca ggaagtctta atctggggtc cacagaacac tagggggctg
     16741 gtgaagttta tagaaaaaaa atctgtattt ttacttacat gtaactgaaa tttagcattt
     16801 tcttctactt tgaatgcaaa ggacaaacta gaatgacatc atcagtacct attgcatagt
     16861 tataaagaga aaccacagat attttcatac tacaccatag gtattgcaga tctttttgtt
     16921 tttgtttttg tttgagatgg agtttcgctc ttattgccca ggctggagtg cagtggcatg
     16981 atttcggctc actgcaacct ccccttcctg cattcaagca attctcctgc cttggcctcc
     17041 agagtagctg gggattacag gcacctgcca ccatgccagt ctaatttttg tatttttagt
     17101 agagatgggg tttcgccatg ttggccaggc tggtcttgaa ctcctgacct cagatgatct
     17161 gcccgccttg gcctcctgaa gtgctgggat tataggtgtg agccaccacg cctggcccat
     17221 tgcagatatt tttaattcac atttatctgc atcactactt ggatcttaag gtagctgtag
     17281 acccaatcct agatctaatg ctttcataaa gaagcaaata taataaatac tataccacaa
     17341 atgtaatgtt tgatgtctga taatgatatt tcagtgtaat taaacttagc actcctatgt
     17401 atattatttg atgcaataaa aacatatttt ttttagcact tacagtctgc caaactggcc
     17461 tgtgacacaa aaaaagttta ggaattcctg gttttgtctg tgttagccaa tggttagaat
     17521 atatgctcag aaagatacca ttggttaata gctgaaagaa aatggagtag aaattcagtg
     17581 gcctggaata ataacaattt gggcagtcat taagtcaggt gaagacttct ggaatcatgg
     17641 gagaaaagca agggagacat tcttacttgc cacaagtgtt tttttttttt tttttttatc
     17701 acaaacataa gaaaatataa taaataacaa agtcaggtta tagaagagag aaacgctctt
     17761 agtaaacttg gaatatggaa tccccaaagg cacttgactt gggagacagg agccatactg
     17821 ctaagtgaaa aagacgaaga acctctaggg cctgaacata ggaaattgta ggaacagaaa
     17881 ttcctagatc tggtggggca aggggagcca taggagaaag aaatggtaga aatggatgga
     17941 gacggaggca gaggtgggca gatcatgagg tcaagagatc gagaccatcc tggcaaacat
     18001 ggtgaaatcc cgtctctact aaaaataaaa aaattagctg ggcatggtgg catgcgcctg
     18061 tagtcccagc tgctcgggag gctgaggcag gagaatcgtt tgaacccagg aggcgaaggt
     18121 tgcagtgagc tgagatagtg ccattgcact ccagtctggc aacagagtga gactccgtct
     18181 caaaaaaaaa aaaaagaaag aaagaaaaga aaaagaaaaa agaaaaaata aatggatgta
     18241 gaacaagcca gaaggaggaa ctgggctggg gcaatgagat tatggtgatg taagggactt
     18301 ttatagaatt aacaatgctg gaatttgtgg aactctgctt ctattattcc cccaatcatt
     18361 acttctgtca cattgatagt taaataattt ctgtgaattt attccttgat tctaaaatat
     18421 gaggataatg acaatggtat tataagggca gattaagtga tatagcataa gcaatattct
     18481 tcaggcacat ggatcgaatt gaatacactg taaatcccaa cttccagttt cagctctacc
     18541 aagtaaagag ctagcaagtc atcaaaatgg ggacatacag aaaaaaaaaa ggacactaga
     18601 ggaataatat accctgactc ctagcctgat taatatatcg attcactttt ttctctgttt
     18661 gatgacaaat tctggcttta aataatttta ggattttagg cttctcagct cccttcccag
     18721 tgagaagtat aagcaggaca gacaggcaag caagaagaga gccccaggca atactcacaa
     18781 agtagccagt gtcccctgtg gtcatagaga aatgaaaaga gagaggattc cctggaagca
     18841 ctggatgtaa tcttttctgt ctgtcctctc tagggaatca ccccaaggta ctgtactttg
     18901 ggattaaggc tttagtccca ctgtggacta cttgctattc tgttcagttt ctagaaggaa
     18961 ctatgtacgg tttttgtctc cctagagaaa ctaaggtaca gaagttttgt ttacaatgca
     19021 ctccttaaga gagctagaac tgggtgagat tctgttttaa cagctttatt ttcttttcct
     19081 tggccctgtt tttgtcaact gtcaccacct ttaaggcaaa tgttaaatgt gctttggctg
     19141 aaactttttt tcctattttg agatttgctc ctttatatga ggctttcttg gaaaaggaga
     19201 atgggagaga tggatatcat tttggaagat gatgaagagg gtaaaaaagg ggacaaatgg
     19261 aaatttgtgt tgcagataga tgaggagcca acaaaaaaga gcctcaggat ccagcacaca
     19321 ttatcacaaa cttagtgtcc atccatcact gctgaccctc tccggacctg actccacccc
     19381 tgaggacaca ggtcagcctt gaccaatgac ttttaagtac catggagaac agggggccag
     19441 aacttcggca gtaaagaata aaaggccaga cagagaggca gcagcacata tctgcttccg
     19501 acacagctgc aatcactagc aagctctcag gcctggcatc atggtgcatt ttactgctga
     19561 ggagaaggct gccgtcacta gcctgtggag caagatgaat gtggaagagg ctggaggtga
     19621 agccttgggc aggtaagcat tggttctcaa tgcatgggaa tgaagggtga atattaccct
     19681 agcaagttga ttgggaaagt cctcaagatt ttttgcatct ctaattttgt atctgatatg
     19741 gtgtcatttc atagactcct cgttgtttac ccctggaccc agagattttt tgacagcttt
     19801 ggaaacctgt cgtctccctc tgccatcctg ggcaacccca aggtcaaggc ccatggcaag
     19861 aaggtgctga cttcctttgg agatgctatt aaaaacatgg acaacctcaa gcccgccttt
     19921 gctaagctga gtgagctgca ctgtgacaag ctgcatgtgg atcctgagaa cttcaaggtg
     19981 agttcaggtg ctggtgatgt gattttttgg ctttatattt tgacattaat tgaagctcat
     20041 aatcttattg gaaagaccaa caaagatctc agaaatcatg ggtcgagctt gatgttagaa
     20101 cagcagactt ctagtgagca taaccaaaac ttacatgatt cagaactagt gacagtaaag
     20161 gactactaac agcctgaatt ggcttaactt ttcaggaaat cttgccagaa cttgatgtgt
     20221 ttatcccaga gaattgtatt atagaattgt agacttgtga aagaagaatg aaatttggct
     20281 tttggtagat gaaagtccat ttcaaggaaa tagaaatgcc ttattttatg tgggtcatga
     20341 taattgaggt ttagaagaga tttttgcaaa aaaaataaaa gatttgctca aagaaaaata
     20401 agacacattt tctaaaatat gttaaatttc ccatcagtat tgtgaccaag tgaaggcttg
     20461 tttccgaatt tgttggggat tttaaactcc cgctgagaac tcttgcagca ctcacattct
     20521 acatttacaa aaattagaca attgcttaaa gaaaaacagg gagagaggga acccaataat
     20581 actggtaaaa tggggaaggg ggtgagggtg taggtaggta gaatgttgaa tgtagggctc
     20641 atagaataaa attgaaccta agctcatctg aattttttgg gtgggcacaa accttggaac
     20701 agtttgaggt cagggttgtc taggaatgta ggtataaagc cgtttttgtt tgtttgtttg
     20761 ttttttcatc aagttgtttt cggaaacttc tactcaacat gcctgtgtgt tattttgtct
     20821 tttgcctaac agctcctggg taacgtgatg gtgattattc tggctactca ctttggcaag
     20881 gagttcaccc ctgaagtgca ggctgcctgg cagaagctgg tgtctgctgt cgccattgcc
     20941 ctggcccata agtaccactg agttctcttc cagtttgcag gtcttcctgt gaccctgaca
     21001 ccctccttct gcacatgggg actgggcttg gccttgagag aaagccttct gtttaataaa
     21061 gtacattttc ttcagtaatc aaaaattgca attttatctt ctccatcttt tactcttgtg
     21121 ttaaaaggaa aaagtgttca tgggctgagg gatggagaga aacataggaa gaaccaagag
     21181 cttccttaag aaatgtatgg gggcttgtaa aattaatgtg gatgttatgg gagaattccc
     21241 aagattccca aggaggatga tatgatggag aaaaatcttt atcggggtgg gaaaatggtt
     21301 aattaagtgg cagagactcc taggcagttt ttactgcacc ggggaaagaa ggagctgttg
     21361 tggtacctga gaaagcagat ttgtggtaca tgtcactttt cattaaaaac aaaaacaaaa
     21421 caaaacaaaa cttcatagat atccaagata taggctgaga attactattt taatttactc
     21481 ttatttacat tttgaagtag ctagcttgtc acatgtttta tgaaattgat ttggagataa
     21541 gatgagtgtg tatcaacaat agcctgctct ttccatgaag gattccatta tttcatgggt
     21601 tagctgaagc taagacacat gatatcattg tgcattatct tctgatacaa tgtaacatgc
     21661 actaaaataa agttagagtt aggacctgag tgggaaagtt tttggagagt gtgatgaaga
     21721 ctttccgtgg gagatagaat actaataaag gcttaaattc taaaaccagc aagctagggc
     21781 ttcgtgactt gcatgaaact ggctctctgg aagtagaagg gagagtaaga catacgtaga
     21841 ggactaggaa agaccagata gtacagggcc tggctacaaa aatacaagct tttactatgc
     21901 tattgcaata ctaaacgata agcattagga tgttaagtga ctcaggaaat aagattttgg
     21961 gaaaaagtaa tctgcttatg tgcacaaaat ggattcaagt ttgcagataa aataaaatat
     22021 ggatgatgat tcaaggggac agatacaatg gttcaaaccc aagaggagca gtgagtctgt
     22081 ggaattttga aggatggaca aaggtggggt gagaaagaca tagtattcga cctgactgtg
     22141 ggagatgaga aggaagaagg aggtgataaa tgactgaaag ctcccagact ggtgaagata
     22201 acaggaggaa accatgcact tgaccctggt gactctcatg tgtgaagggt agagggatat
     22261 taacagattt actttttagg aagtgctaga ttggtcaggg agttttgacc ttcaggtctt
     22321 gtgtctttca tatcaaggaa cctttgcatt ttccaagtta gagtgccata ttttggcaaa
     22381 tataacttta ttagtaattt tatagtgctc tcacattgat cagacttttt cctgtgaatt
     22441 acttttgaat ttggctgtat atatccagaa tatgggagag agacaaataa ttattgtagt
     22501 tgcaggctat caacaatact ggtctctctg agccttataa cctttcaata tgccccataa
     22561 acagagtaaa cagggattat tcatggcact aaatattttc acctaggtca gtcaacaaat
     22621 ggaggcaatg tgcatttttt gatacatatt tttatatatt tatggggcat gtgatactta
     22681 catgcctaga acatgtgact gattaagtct agatatttag gatatccatt actttgagca
     22741 tttatcattt ctatgtattg agaaaatttc aaatcctcat ttctgaccat tttgaaatat
     22801 ataataaata gtaattaact atagtcaccc tactcaaata tcaacattat aaactaacta
     22861 atccttcttt ccactttttt accaaccaac atctcttaaa tcccctgcca tacacatcac
     22921 acatttttca gctctgataa ctatcattct actctcatac caccatgaga ccactttttt
     22981 agctccacag atgaataaaa acatgtgata tttgactttc tgtatctggc ttattttatt
     23041 atctatctct ttggcatacc aagagtttgt ttttgttctg cttcagggct ttcaattaac
     23101 ataatgacct ctggttccat ccatgttgct acaaatgaca agatttcatt ctttttcatg
     23161 gcaaaatagt actgtgcaaa aaatacaatt ttttaatccg ttcatctgtt gatagacact
     23221 taggttgatc ccaaacctta actattgtga ataggtgctt caataaacat gagtgtaatg
     23281 tgtccattgg atatactgat ttcctttctt ttggataaat aaccactagt gagattgctg
     23341 gattgtatga tagttctgtt tttagtttat tgagaaatct tcatactgtt ttccataatg
     23401 gttgtactat tttacattcc caccaacagt gtgtaagaaa gagttccctt ttctccatat
     23461 cctcacaagg atctgttatt ttttgtcttt tttgttaata gcattttaac tagagtaagt
     23521 agatatctca ttgtagtttt gatttgcatt tccctgatca ttagtgatgt tgagattttt
     23581 tcatatgttt gttggtcatt tgtatatctt tttctgagat tgtctgttca tgtccttatc
     23641 ctacttttat tgggattgtt gttattttct tgataatcat tgtgtcattt tagagcctgg
     23701 atattattct tttgtcagat gtatagattg tgaagatttt ctcctctgtg ggttgtctgt
     23761 ttattctgca gactcttcct tttgccatgc aaaagctctt tagtttaatt tagtcccaga
     23821 tattttcttt gtttttatgt gtttgcattt gtgttcttgt catgaaatcc tttcctaagc
     23881 caatgtgtag aagggttttt ccgatgttat tttctagaat tgttacagtt tcaggcttag
     23941 atttaagtcc ttgatccatc ttaagttgat ttttgtataa ggtgagagat gaagatccag
     24001 tttcattctc ctacatgtag cttgccagct atcccgactc atttgttgaa tagggtgccc
     24061 tttcccattt atgtttttgt ttgctttgtc aaagatcagt tcggatgtaa gtatttgagt
     24121 ttatttctgg gttctctatt ctgttccatt ggtccgatgt gcctatttgt acaccagcat
     24181 catgctgtgt ttttggtgac tatggcctta ttgtatagtt tgaaatgagg taatgtaatg
     24241 ccattcagat ttgttctttt ttttagactt gcttgtttat tgggctcttt tttggttcca
     24301 taagaatttt aggattgttt tttctagttc tgtgaaggct aatggtggta tttatgggaa
     24361 ttgcaatgca atttgtaggt tgcttctggc attatggcca ttttcacaat attgattcta
     24421 cccatctatg agaatggcat gtgtttccat ttgtttgtgt cttatatgat tactatcagc
     24481 cgtgttttgt agttttcctt gtagatgtct ttcacctcct tggttaggta tatattccta
     24541 agtttttgtt ttgttttgtt ttgttttttg cagctattgt aaaaggggtt gagttattga
     24601 ttttattctc atcttggtca ttgctggtat gtaagaaagc aactcattgg tgtacgttaa
     24661 ttttgtatcc agaaactttg ctgaattatt ttatcagttc tagggggttt tggaggagtc
     24721 tttagagttt tctacataca caatcatatc atcagcaaac agtgacagtt tgactttctc
     24781 tttaacaatt tggatgtgct ttacttgttt ctcttgtctg attgctcttg ctaggacttc
     24841 cagtaatatg ttaaagagaa gtggtgagag tgggtatcct tgtctcattc cagttttcag
     24901 acagaatgct tttaactttt tcccattcaa tataatgttg gctgtgtgtt taccatagct
     24961 ggcttttatt acattgaggt atgtcctttg taaaccgatt ttgctgagtt ttagtcataa
     25021 agtgatgttg aattttgttg aatgcagttt ctgtggctat tgagataatc acatgatttt
     25081 tgtttccaat tctctttatg ttgtgtatca cacttattga cttgcgtatg ttaaaccatc
     25141 cgtgcatccc tcgcatgaaa ccacttgatc atgggttttg atatgccgtg tgggatgcta
     25201 ttagctatat tttgtcaagg atgttggcat ctatgttcat cagggatatt gatctgtagt
     25261 gttttttttt tttggttatg ttctttccca gttttggtat taaggtgata ctggcttcat
     25321 agaatgattt agggaggatt ctctctttct ctatcttgta gaatactgtc aataggattg
     25381 gtatcaattc ttctttgaat gtctggtaga attcgaacgt ctcctttagg ttttctagtt
     25441 tattcatgta aaggtgttca tagtaacctt gaataatctt ttgtatttct gtggtatcag
     25501 taatagtatc tcctgttttg tttctaactg agtttatttg cacttctctc ctcttttctt
     25561 ggttaatctt gctaatggtc tatcagtttt atttatcttt tcaaagaacc agctttttat
     25621 ttcatttagc ttttgtattt ttttgcagtt gttttaattt catttagttc tcctcttatc
     25681 ttagttattc cctttctttt gctgggtttt ggttctgttt gtttttgttt ctctagtttc
     25741 ttgtggtgtg accttatatt gtctgtcctc tttcagactc tttgacatcg acatttaggg
     25801 ctgtgaactt tccttttagc accatctttg ctgtatccta gaggttttga taggtgtgtc
     25861 actattgtcg gtcagttcaa gtaattttgt tgttcttatt atactttaag ttctgggata
     25921 catgtgcaga atgtgcaggt ttgttacata ggtatagatg tgccatggtg gtttgctgct
     25981 cccatcaacc tgtcatctac attaggtatt tcttttaatg ttatccctct cctaaccccc
     26041 tcaccccccg acaggccctg gtgtgtgatg ttcccctccc tgtgtccatg tgttctcatt
     26101 gttcaactcc cacttatgag tgagaacgtg tggtgtttgg tttctctgtt cctgtgttag
     26161 tttgctcaga atgatgtttc caccttcacc atgtccctgc aaagacatga actcatcatt
     26221 ttatggctgc atatattcca tggtgtatat gtgccacatt ttctttatcc attatatcgc
     26281 tgatggccat ttgggttggt tccaagtctt tggtattgtg aatagtgccg caataaacat
     26341 acgtgtgcac atgtctttat agtagaatga tttctaattc tttgggtata tacccagtaa
     26401 tgggattgct gggtcaaaca gtatttctgg ttctagatcc ttgaggaatt gccacactgt
     26461 cttccacaat ggttgaacta atttacacac ccatcaacag tgtaaaattt ttcctattct
     26521 tccacatcct ctccagcacc ttttgtttcc tgacttttta ataattgcca ttctaactgg
     26581 catgagatgg tatctcattg tggttttgat ttgcatttct ctaatgacca gtgatgatga
     26641 gcttcttttc atgtgtttct tggccacata aatgacttct ttagagaagc atctgttcat
     26701 atcctttgtc cactttttga tggggtcgtt aggttttttc ttgtaaattt gttgaagttc
     26761 tttgtagatt ttggatgtta gccctttgtc agatggatag attggcaaaa attttctccc
     26821 attctgtagg ttgcctgttc actctgatga tagtcttttg ctgtgcagaa gctctttagt
     26881 ttaattagat cccatatgtc aattttggcc tttgttgtca ttgcttttga tgtttagtcg
     26941 tggaattttg cccatgccta tgtcctgaat ggtattgcct aggttatctt ctaggatttt
     27001 tatggtttta ggttgcacat ttaagtcttt aatccacctt gagttaattt ttgtataagg
     27061 tgtaaggaag gggtacagtt tcagttttat gcatattgct agccagtttt tccagcacca
     27121 tttattaaat agggaattct ttctccattg cttttgtgat gtttgtcaaa gatcagatgg
     27181 tcgtagatgt gtggcattat ttctgaggct tctgttctgt tccactggtc tatatatctg
     27241 ttttggtacc agtaccatgc tgtttttgtt actgtagcct tgtagtatag cttgaagtca
     27301 ggtagcatca tgcctccagc tttgttcttt ttgtttagga ttgtcttggc tatatgggct
     27361 cttttttgat tccatatgac atttaaagta gttttttcta attctttgaa aaaagtcagt
     27421 ggtagcttga tggggatagc attgaatcta taaattactt tgggcagtat ggccatttta
     27481 aagatattga ttctttctat ctatgagcat ggaatgtttt tccatttgtt tgtgtcctct
     27541 cttatttcct tgagcagtga gtggtttgta gctctccttg aagaggttct tcacatccct
     27601 tataagttgt atttctaggt attttatttt attctctttg cagcaattgt gaatgggagt
     27661 tcacccatga tttggctctc tgcttgtcta ttattggtgt ataggaatgc ttgtgatttt
     27721 tgcacactga ttttgtatct tgagactttg ctgaagctgt ttatcagctt aagattttgg
     27781 gctgagatga cagggtcttc taaatataca atcatgtcat ctgcaaacag agacaatttg
     27841 acttcctctc ttcctatttg aatatgcttt atttctttct cttgcctgat tgtcctggcg
     27901 agaacttcca atactatgtt gagtaagagt ggcgagaggg catccttgtc ttgtgccggt
     27961 tttcaaagca aatgattttt aaatttccgt cttgatttca ttgttgaccc aatgatcatt
     28021 caggagcagg ttatttaatt tccctgtatt tgcatggttt tgaaggttcc ttttgtagtt
     28081 gatttccaat tttattctac tgtggtctga gagagtgctt gatataattt caatttttaa
     28141 aaatttattg aggcttgttt tgtggcatat catatggcct atcttggaga aagttccatg
     28201 tgctgatgaa tagaatgtgt attctgcagt tgttgggtag aatgtcctgt aaatatctgt
     28261 taagtccatt tgttctttaa atccattgtt tctttgtaga ctgtcttgat gacctgccta
     28321 gtgcagtcag tggagtattg aagtccccca ctattattat gttgctgtct agtagtaatt
     28381 gttttataaa tttgggatct ccagtattag atgcatatat attaagaatt gtaatattct
     28441 cccattggac aagggctttt atcattatat gatgtccctc tttgtctttt ttaactgctg
     28501 tttctttaaa gtttgttttg tctgacataa gaatagctgc tttggctcgc ttttggtgtc
     28561 catttgtgtg gaatgtcatt ttccacccct ttaccttaag tttatgtgag tccttatgtg
     28621 ttaggtgagt ctcctgaagg cggcagataa ctggttggtg aattctattc attctgcaat
     28681 tctgtatctt ttaagtggag catttagtcc atttacattc aacatcagta ttgaggtgtg
     28741 aggtgactat tccattcttc gtggtatttg ttgcctgtgt atctttttat ctgtattttt
     28801 gttgtatatg tcctatggga tttatgcttt aaagaggttc tgttttgatg tgcttccagg
     28861 gtttatttca agatttagag ctccttttat cattcttgta gtgttggctt ggtagtgccg
     28921 aattctctca gcatttgttt ttctgaaaaa cactgtgtat tttcttcatt tgtgaagctt
     28981 agtttcactg gatataaaat tcttggctga taattgtttt gtttaagaag gctgaagata
     29041 gggccatatt cacttctagc ttttacggtt tctgctgaga aatctgctgt taatctgata
     29101 ggttttcttt cataggttac ctggtagttt cacctcacag ctcttaagat tctctttgtc
     29161 tttagataac tttggatact ctgatgacaa tgtacctagg caatgatatt tttgcaatga
     29221 atttcccagg tgtttattga gcttctttgt atttggatat ctaggtctct agcaaggagg
     29281 gggaagtttt ccttgattat ttccatggac aagttttcca aacttttaga tttctcttct
     29341 ttctcaggaa tgctgattat tcttaggttt gattgtttaa cataatccca gatttcttgg
     29401 aggctttgtt catattttct tattcttttt tctttgtctt tgttggattg ggtaattcaa
     29461 aaactttgtc ttcaagctct gaatttcttc tgcttggatt ctattgctga gactttctag
     29521 agcattttgc atttctataa gtgcatccat tcatccattg tttcctgaag ttttgaatgt
     29581 tttttattta tgctatctct ttaactgaag atttctcccc tcatttcttg tatcatattt
     29641 ttggtttttt taaaattgga cttcaccttc ctcggatgcc tccttgatta gcttaataac
     29701 tgaccttctg aattattttt caggtaaatc agggatttct tcttggtttg gatgcattgc
     29761 tggtgagcta gtatgatttt ttggggggtg ttaaagaacc ttgtttttca tattaccaga
     29821 gttagttttc tggttccttc tcacttgggt aggctctgtc agagggaaag tctaggcctc
     29881 aaggctgaga cttttgtccc agcaggtgtt cccttgatgt agcacagtcc cccttttcct
     29941 aggacgtggg gcttcctgag agccgaactg tagtgattgt tatctctctt ctggatctag
     30001 ccacccatca ggtctaccag actccaggct ggtactgggg tttgtctgca cagagtcttg
     30061 tgacgtgaac catctgtggg tctctcagcc atagatacaa ccacctgctc caatggaggt
     30121 ggtagaggat gaaatgaact ctgtgagggt ccttactttt ggttgttcaa tgcactatct
     30181 ttttgtgctg gttggcctcc tgccaggagg tggcactttc tagaaagcat cagcagaggc
     30241 agtcaggtgg tggtggctgg gggggctggg gcactagaac tcccaagaat atatgccctt
     30301 tgtcttcagc tactagggtg agtaaggaag gaccatcagg tgggggcagg actagtcgtg
     30361 tctgagctca gagtctcctt gggcaggtct ttctgtggct actgtgggag gatgggggtg
     30421 tagtttccag gtcaatggat ttatgttcct aggacaatta tggctgcctc tgctgtgtca
     30481 tgcaggtcat caggaaagtg ggggaaagca agcagtcacg tgacttgccc agctcccatg
     30541 caactcaaaa ggttggtctc acttccagcg tgcaccctcc cccgcaacag ctccgaatct
     30601 gtttccatgc agtcagtgag caaggctgag aacttgccca ggctaccagc tgcgaaacca
     30661 agtagggctg tcctacttcc ctgccagtgg agtctgcaca ccaaattcat gtccccccac
     30721 caaccccccc actgcccagc ccctagatct ggccaggtgg agattttctt tttcctgtct
     30781 cttttcccag ttcctctggc agccctccca aatgacccct gtgaggcaag gcagaaatgg
     30841 cttcctaggg gacccagaga gcccacaggg cttttcccgc tgcttcctct acccctgtat
     30901 tttgcttggc cctctaaatt gactcagctc caggtaaggt cagaatcttc tcctgtggtc
     30961 tagatcttca ggttcccagt gaggatgtgt gtttgggggt agacggtccc ccttttccac
     31021 ttccacagtt tgggcactca caatatttgg ggtgtttccc gggtcctaca tgagcaatct
     31081 gcttctttca gagggtgtgt gcgttctctc agctttcttg aatttatttc tgcaggtggt
     31141 tctgcaaaaa aaattcctga tgggagactt cacatgctgc tctgtgcatc cgagtgggag
     31201 ctgcaatgta cttctgctgc cacccatctg ccatcaccct ctaatttgtc ggtaatatgc
     31261 atttttaatc aatctttttt tctctctctc tcttttcttc tcccccaaaa ctatactgcc
     31321 ctttgatatc aaggaatcaa ggccgtgatg ttgaggggtg ggcagtggat acactcttta
     31381 ccccttaggg agcatatcta gatttagata ttgccaattc aagataactt aattgaaagc
     31441 aaattcataa tgaatacaca cacacacaca cacatctgca tgacaagatt tttaatagtt
     31501 gaaagaataa ctaataattg tccacaggca ataagggctt tttaagcaaa acagttgtga
     31561 taaaacaggt cattcttaga atagtaatcc agccaatagt acaggttgct tagagattat
     31621 gacattacca gagttaaaat tcaataatgg cttctcactc cctaccactg aggacaagtt
     31681 tatgtcctta ggtttatgct tccctgaaac aataccacct gctattctcc actttacata
     31741 tcaacggcac tggttcttta tctaactctc tggcacagca ggagtttgtt ttcttctgct
     31801 tcagagcttt gaatttacta tttcagcttc taaactttat ttgcaatgcc ttcccatggc
     31861 agactccttc tgtcattttg cctctgttcg aaaacttttt ccttaatttc attcttagtt
     31921 aataatatct gaaattattt tgttgtttaa cttaattatt aattttatgt atgttctacc
     31981 tagatataat cttctagagg attgttttat tctctgactt atttaactta aatgcccact
     32041 acctttaaaa attatgacat ttatttaaca gatatttgct gaacaaatgt ttgaaaatac
     32101 atgggaaaga atgcttgaaa acacttgaaa ttgcttgtgt aaagaaacag ttttatcagt
     32161 taggatttaa tcaatgtcag aagcaatgat ataggaaaaa tcgaggaata agacagttat
     32221 ggataaggag aaatcaacaa actcttaaaa gatattgcct caaaagcata agaggaaata
     32281 agggtttata catgactttt agaacactgc ctgggttttt ggataaatgg ggaagttgtt
     32341 ggaaaacagg agggatccta gatattcctt agtctgagga ggagcaatta agattcactt
     32401 gtttagaggc tgggagtggt ggctcacgcc tgtaatccca gaattttggg aggccaaggc
     32461 aggcagatca cctgaggtca agagttcaag accaacctgg ccaacatggt gaaatcccat
     32521 ctctacaaaa atacaaaaat tagacaggca tgatggcaag tgcctgtaat cccagctact
     32581 tgggaggctg aggaaggaga attgcttgaa cctggaaggc aggagttgca gtgagccgag
     32641 atcataccac tgcactccag cctgggtgac agaacaagac tctgtctcaa aaaaaaaaaa
     32701 gagagattca aaagattcac ttgtttaggc cttagcgggc ttagacacca gtctctgaca
     32761 cattcttaaa ggtcaggctc tacaaatgga acccaaccag actctcagat atggccaaag
     32821 atctatacac acccatctca cagatcccct atcttaaaga gaccctaatt tgggttcacc
     32881 tcagtctcta taatctgtac cagcatacca ataaaaatct ttctcaccca tccttagatt
     32941 gagagaagtc acttattatt atgtgagtaa ctggaagata ctgataagtt gacaaatctt
     33001 tttctttcct ttcttattca acttttattt taacttccaa agaacaagtg caatatgtgc
     33061 agctttgttg cgcaggtcaa catgtatctt tctggtcttt tagccgccta acactttgag
     33121 cagatataag ccttacacag gattatgaag tctgaaagga ttccaccaat attattataa
     33181 ttcctatcaa cctgataagt taggggaagg tagagctctc ctccaataag ccagatttcc
     33241 agagtttctg acgtcataat ctaccaaggt catggatcga gttcagagaa aaaacaaaag
     33301 caaaaccaaa cctaccaaaa aataaaaatc ccaaagaaaa aataaagaaa aaaacagcat
     33361 gaatacttcc tgccatgtta agtggccaat atgtcagaaa cagcactgag ttacagataa
     33421 agatgtctaa actacagtga catcccagct gtcacagtgt gtggactatt agtcaataaa
     33481 acagtccctg cctcttaaga gttgttttcc atgcaaatac atgtcttatg tcttagaata
     33541 agattcccta agaagtgaac ctagcattta tacaagataa ttaattctaa tccatagtat
     33601 ctggtaaaga gcattctacc atcatcttta ccgagcatag aagagctaca ccaaaaccct
     33661 gggtcatcag ccagcacata cacttatcca gtgataaata cacatcatcg ggtgcctaca
     33721 tacatacctg aatataaaaa aaatactttt gctgagatga aacaggcgtg atttatttca
     33781 aataggtacg gataagtaga tattgaagta aggattcagt cttatattat attacataac
     33841 attaatctat tcctgcactg aaactgttgc tttataggat ttttcactac actaatgaga
     33901 acttaagaga taatggccta aaaccacaga gagtatattc aagaataagt atagcacttc
     33961 ttatttggaa accaatgctt actaaatgag actaagacgt gtcccatcaa aaatcctgga
     34021 cctatgccta aaacacattt cacaatccct gaacttttca aaaattggta catgctttaa
     34081 ctttaaacta caggcctcac tggagctaca gacaagaagg tgaaaaacgg ctgacaaaag
     34141 aagtcctggt atcttctatg gtgggagaag aaaactagct aaagggaaga ataaattaga
     34201 gaaaaattgg aatgactgaa tcggaacaag gcaaaggcta taaaaaaaat taagcagcag
     34261 tatcctcttg ggggcccctt ccccacacta tctcaatgca aatatctgtc tgaaacggtt
     34321 cctggctaaa ctccacccat gggttggcca gccttgcctt gaccaatagc cttgacaagg
     34381 caaacttgac caatagtctt agagtatcca gtgaggccag gggccggcgg ctggctaggg
     34441 atgaagaata aaaggaagca cccttcagca gttccacaca ctcgcttctg gaacgtctga
     34501 ggttatcaat aagctcctag tccagacgcc atgggtcatt tcacagagga ggacaaggct
     34561 actatcacaa gcctgtgggg caaggtgaat gtggaagatg ctggaggaga aaccctggga
     34621 aggtaggctc tggtgaccag gacaagggag ggaaggaagg accctgtgcc tggcaaaagt
     34681 ccaggtcgct tctcaggatt tgtggcacct tctgactgtc aaactgttct tgtcaatctc
     34741 acaggctcct ggttgtctac ccatggaccc agaggttctt tgacagcttt ggcaacctgt
     34801 cctctgcctc tgccatcatg ggcaacccca aagtcaaggc acatggcaag aaggtgctga
     34861 cttccttggg agatgccata aagcacctgg atgatctcaa gggcaccttt gcccagctga
     34921 gtgaactgca ctgtgacaag ctgcatgtgg atcctgagaa cttcaaggtg agtccaggag
     34981 atgtttcagc actgttgcct ttagtctcga ggcaacttag acaactgagt attgatctga
     35041 gcacagcagg gtgtgagctg tttgaagata ctggggttgg gagtgaagaa actgcagagg
     35101 actaactggg ctgagaccca gtggcaatgt tttagggcct aaggagtgcc tctgaaaatc
     35161 tagatggaca actttgactt tgagaaaaga gaggtggaaa tgaggaaaat gacttttctt
     35221 tattagattt cggtagaaag aactttcacc tttcccctat ttttgttatt cgttttaaaa
     35281 catctatctg gaggcaggac aagtatggtc gttaaaaaga tgcaggcaga aggcatatat
     35341 tggctcagtc aaagtgggga actttggtgg ccaaacatac attgctaagg ctattcctat
     35401 atcagctgga cacatataaa atgctgctaa tgcttcatta caaacttata tcctttaatt
     35461 ccagatgggg gcaaagtatg tccaggggtg aggaacaatt gaaacatttg ggctggagta
     35521 gattttgaaa gtcagctctg tgtgtgtgtg tgtgtgtgtg cgcgcgtgtg tttgtgtgtg
     35581 tgtgagagcg tgtgtttctt ttaacgtttt cagcctacag catacagggt tcatggtggc
     35641 aagaagataa caagatttaa attatggcca gtgactagtg ctgcaagaag aacaactacc
     35701 tgcatttaat gggaaagcaa aatctcaggc tttgagggaa gttaacatag gcttgattct
     35761 gggtggaagc ttggtgtgta gttatctgga ggccaggctg gagctctcag ctcactatgg
     35821 gttcatcttt attgtctcct ttcatctcaa cagctcctgg gaaatgtgct ggtgaccgtt
     35881 ttggcaatcc atttcggcaa agaattcacc cctgaggtgc aggcttcctg gcagaagatg
     35941 gtgactggag tggccagtgc cctgtcctcc agataccact gagctcactg cccatgatgc
     36001 agagctttca aggataggct ttattctgca agcaatacaa ataataaatc tattctgcta
     36061 agagatcaca catggttgtc ttcagttctt ttttttatgt ctttttaaat atatgagcca
     36121 caaagggttt tatgttgagg gatgtgttta tgtgtattta tacatggcta tgtgtgtttg
     36181 tgtcatgtgc acactccaca cttttttgtt tacgttagat gtgggttttg atgagcaaat
     36241 aaaagaacta ggcaataaag aaacttatac atgggagcgt ctgcaagtgg gagtaaaagg
     36301 tgcaggagaa atctggttgg aagaaagacc tctataggac aggactcctc agaaacagat
     36361 gttttggaag agatggggaa aggttcagtg aagggggctg aacccccttc cctggattgc
     36421 agcacagcag cgaggaaggg gctcaacgaa gaaaaagtgt tccaagcttt aggaagtcaa
     36481 ggtttaggca gggatagcca ttctatttta ttaggggcaa tactatttcc aacggcatct
     36541 ggcttttctc agcccttgtg aggctctacg gggaggttga ggtgttagag atcagagcag
     36601 gaaacaggtt tttctttcca cggtaactac aatgaagtga tccttacttt actaaggaac
     36661 tttttcattt taagtgttga cgcatgccta aagaggtgaa attaatccca tacccttaag
     36721 tctacagact ggtcacagca tttcaaggag gagacctcat tgtaagcttc tagggaggtg
     36781 gggacctagg tgaaggaaat gagccagcag aagctcacaa gtcagcatca gcgtgtcatg
     36841 tctcagcagc agaacagcac ggtcagatga aaatatagtg tgaagaattt gtataacatt
     36901 aattgagaag gcagattcac tggagttctt atataattga aagttaatgc acgttaataa
     36961 gcaagagttt agtttaatgt gatggtgtta tgaacttaac gcttgtgtct ccagaaaatt
     37021 cacatgctga atccccaact cccaattggc tccatttgtg ggggaggctt tggaaaagta
     37081 atcaggttta gaggagctca tgagagcaga tccccatcat agaattattt tcctcatcag
     37141 aagcagagag attagccatt tctcttcctt ctggtgagga cacagtggga agtcagccac
     37201 ctgcaaccca ggaagagagc cctgaccagg aaccagcaga aaagtgagaa aaaatcctgt
     37261 tgttgaagtc acccagtcta tgctattttg ttatagcacc ttgcactaag taaggcagat
     37321 gaagaaagag aaaaaaataa gcttcggtgt tcagtggatt agaaaccatg tttatctcag
     37381 gtttacaaat ctccacttgt cctctgtgtt tcagaataaa ataccaactc tactactctc
     37441 atctgtaaga tgcaaatagt aagcctgatc ccttctgtct aacttcgaat tctatttttt
     37501 cttcaacgta ctttaggctt gtaatgtgtt tatatacagt gaaatgtcaa gttctttctt
     37561 tatatttctt tctttctttt ttttcctcag cctcagagtt ttccacatgc ccttcctacc
     37621 ttcaggaact tctttctcca aacgtcttct gcctggcctc cattcaaatc ataaaggacc
     37681 cacttcaaat gccatcactc actaccattt cacaattcgc actttctttc tttgtccttt
     37741 ttttttttag taaaacaagt ttataaaaaa ttgaaggaat aaatgaatgg ctacttcata
     37801 ggcagagtag acacaagggc tactggttgc cgatttttat tgttattttt caatagtatg
     37861 ctaaacaagg ggtagattat ttatgctgcc catttttaga ccataaaaga taacttcctg
     37921 atgttgccat ggcatttttt ttccttttaa ttttatttca tttcatttta atttcgaagg
     37981 tacatgtgca ggatgtgcag gcttgttaca tgggtaaatg tgtgtctttc tggcctttta
     38041 gccatctgta tcaatgagca gatataagct ttacacagga tcatgaagga tgaaagaatt
     38101 tcaccaatat tataataatt tcaatcaacc tgatagctta ggggataaac taatttgaag
     38161 atacagcttg cctccgataa gccagaattc cagagcttct ggcattataa tctagcaagg
     38221 ttagagatca tggatcactt tcagagaaaa acaaaaacaa actaaccaaa agcaaaacag
     38281 aaccaaaaaa cctccataaa tacttcctac ccagttaatg gtccaatatg tcagaaacag
     38341 cactgtgtta gaaataaagc tgtctaaagt acactaatat tcgagttata atagtgtgtg
     38401 gactattagt caataaaaac aacccttgcc tctttagagt tgttttccat gtacacgcac
     38461 atcttatgtc ttagagtaag attccctgag aagtgaacct agcatttata caagataatt
     38521 aattctaatc cacagtacct gccaaagaac attctaccat catctttact gagcatagaa
     38581 gagctacgcc aaaaccctgg gtcatcagcc agcacacaca cttatccagt ggtaaataca
     38641 catcatctgg tgtatacata catacctgaa tatggaatca aatatttttc taagatgaaa
     38701 cagtcatgat ttatttcaaa taggtacgga taagtagata ttgaggtaag cattaggtct
     38761 tatattatgt aacactaatc tattactgcg ctgaaactgt ggtctttatg aaaattgttt
     38821 tcactacact attgagaaat taagagataa tggcaaaagt cacaaagagt atattcaaaa
     38881 agaagtatag cactttttcc ttagaaacca ctgctaactg aaagagacta agatttgtcc
     38941 cgtcaaaaat cctggaccta tgcctaaaac acatttcaca atccctgaac ttttcaaaaa
     39001 ttggtacatg ctttagcttt aaactacagg cctcactgga gctacagaca agaaggtaaa
     39061 aaacggctga caaaagaagt cctggtatcc tctatgatgg gagaaggaaa ctagctaaag
     39121 ggaagaataa attagagaaa aactggaatg actgaatcgg aacaaggcaa aggctataaa
     39181 aaaaattaag cagcagtatc ctcttggggg ccccttcccc acactatctc aatgcaaata
     39241 tctgtctgaa acggtccctg gctaaactcc acccatgggt tggccagcct tgccttgacc
     39301 aatagccttg acaaggcaaa cttgaccaat agtcttagag tatccagtga ggccaggggc
     39361 cggcggctgg ctagggatga agaataaaag gaagcaccct tcagcagttc cacacactcg
     39421 cttctggaac gtctgagatt atcaataagc tcctagtcca gacgccatgg gtcatttcac
     39481 agaggaggac aaggctacta tcacaagcct gtggggcaag gtgaatgtgg aagatgctgg
     39541 aggagaaacc ctgggaaggt aggctctggt gaccaggaca agggagggaa ggaaggaccc
     39601 tgtgcctggc aaaagtccag gtcgcttctc aggatttgtg gcaccttctg actgtcaaac
     39661 tgttcttgtc aatctcacag gctcctggtt gtctacccat ggacccagag gttctttgac
     39721 agctttggca acctgtcctc tgcctctgcc atcatgggca accccaaagt caaggcacat
     39781 ggcaagaagg tgctgacttc cttgggagat gccataaagc acctggatga tctcaagggc
     39841 acctttgccc agctgagtga actgcactgt gacaagctgc atgtggatcc tgagaacttc
     39901 aaggtgagtc caggagatgt ttcagcactg ttgcctttag tctcgaggca acttagacaa
     39961 ctgagtattg atctgagcac agcagggtgt gagctgtttg aagatactgg ggttgggagt
     40021 gaagaaactg cagaggacta actgggctga gacccagtgg caatgtttta gggcctaagg
     40081 agtgcctctg aaaatctaga tggacaactt tgactttgag aaaagagagg tggaaatgag
     40141 gaaaatgact tttctttatt agatttcggt agaaagaact ttcacctttc ccctattttt
     40201 gttattcgtt ttaaaacatc tatctggagg caggacaagt atggtcgtta aaaagatgca
     40261 ggcagaaggc atatattggc tcagtcaaag tggggaactt tggtggccaa acatacattg
     40321 ctaaggctat tcctatatca gctggacaca tataaaatgc tgctaatgct tcattacaaa
     40381 cttatatcct ttaattccag atgggggcaa agtatgtcca ggggtgagga acaattgaaa
     40441 catttgggct ggagtagatt ttgaaagtca gctctgtgtg tgtgtgtgtg tgtgtgtgtg
     40501 tcagcgtgtg tttcttttaa cgtcttcagc ctacaacata cagggttcat ggtgggaaga
     40561 agatagcaag atttaaatta tggccagtga ctagtgcttg aaggggaaca actacctgca
     40621 tttaatggga aggcaaaatc tcaggctttg agggaagtta acataggctt gattctgggt
     40681 ggaagctggg tgtgtagtta tctggaggcc aggctggagc tctcagctca ctatgggttc
     40741 atctttattg tctcctttca tctcaacagc tcctgggaaa tgtgctggtg accgttttgg
     40801 caatccattt cggcaaagaa ttcacccctg aggtgcaggc ttcctggcag aagatggtga
     40861 ctgcagtggc cagtgccctg tcctccagat accactgagc ctcttgccca tgattcagag
     40921 ctttcaagga taggctttat tctgcaagca atacaaataa taaatctatt ctgctgagag
     40981 atcacacatg attttcttca gctctttttt ttacatcttt ttaaatatat gagccacaaa
     41041 gggtttatat tgagggaagt gtgtatgtgt atttctgcat gcctgtttgt gtttgtggtg
     41101 tgtgcatgct cctcatttat ttttatatga gatgtgcatt ttgatgagca aataaaagca
     41161 gtaaagacac ttgtacacgg gagttctgca agtgggagta aatggtgttg gagaaatccg
     41221 gtgggaagaa agacctctat aggacaggac ttctcagaaa cagatgtttt ggaagagatg
     41281 ggaaaaggtt cagtgaagac ctgggggctg gattgattgc agctgagtag caaggatggt
     41341 tcttaatgaa gggaaagtgt tccaagcttt aggaattcaa ggtttagtca ggtgtagcaa
     41401 ttctatttta ttaggaggaa tactatttct aatggcactt agcttttcac agcccttgtg
     41461 gatgcctaag aaagtgaaat taatcccatg ccctcaagtg tgcagattgg tcacagcatt
     41521 tcaagggaga gacctcattg taagactctg ggggaggtgg ggacttaggt gtaagaaatg
     41581 aatcagcaga ggctcacaag tcagcatgag catgttatgt ctgagaaaca gaccagcact
     41641 gtgagatcaa aatgtagtgg gaagaatttg tacaacatta attggaaggt ttacttaatg
     41701 gaatttttgt atagttggat gttagtgcat ctctataagt aagagtttaa tatgatggtg
     41761 ttacggacct ggtgtttgtg tctcctcaaa attcacatgc tgaatcccca actcccaact
     41821 gaccttatct gtgggggagg cttttgaaaa gtaattaggt ttagctgagc tcataagagc
     41881 agatccccat cataaaatta ttttccttat cagaagcaga gagacaagcc atttctcttt
     41941 cctcccggtg aggacacagt gagaagtccg ccatctgcaa tccaggaaga gaaccctgac
     42001 cacgagtcag ccttcagaaa tgtgagaaaa aactctgttg ttgaagccac ccagtctttt
     42061 gtattttgtt atagcacctt acactgagta aggcagatga agaaggagaa aaaaataagc
     42121 ttgggttttg agtgaactac agaccatgtt atctcaggtt tgcaaagctc ccctcgtccc
     42181 ctatgtttca gcataaaata cctactctac tactctcatc tataagaccc aaataataag
     42241 cctgcgccct tctctctaac tttgatttct cctattttta cttcaacatg ctttactcta
     42301 gccttgtaat gtctttacat acagtgaaat gtaaagttct ttattctttt tttctttctt
     42361 tcttttttct cctcagcctc agaatttggc acatgccctt ccttctttca ggaacttctc
     42421 caacatctct gcctggctcc atcatatcat aaaggtccca cttcaaatgc agtcactacc
     42481 gtttcaggat atgcactttc tttctttttt gttttttgtt ttttttaagt caaagcaaat
     42541 ttcttgagag agtaaagaaa taaacgaatg actactgcat aggcagagca gccccgaggg
     42601 ccgctggttg ttccttttat ggttatttct tgatgatatg ttaaacaagt tttggattat
     42661 ttatgccttc tctttttagg ccatataggg taactttctg acattgccat ggcatgtttc
     42721 ttttaattta atttactgtt accttaaatt caggggtaca cgtacaggat atgcaggttt
     42781 gttttatagg taaaagtgtg ccatggtttt aatgggtttt ttttttcttg taaagttgtt
     42841 taagtttctt gtttactctg gatattggcc tttgtcagaa gaatagattg gaaaatcttt
     42901 ttcccattct gtagattgtc tttcgctctg atggtagttt cttttgctga gcaggagctc
     42961 tttagtttaa ttagattcca ttggtcaatt tttgcttttg ctgcaattgc ttttcacgct
     43021 ttcatcatga aatctgtgcc cgtgtttata tcatgaatag tattgccttg atttttttct
     43081 aggcttttta tagtttgggg tttttcattt aagtctctaa tccatccgga gttaattttg
     43141 gataaggtat aaggaaggag tccagtttca tttttcagca tatggctagc cagttctccc
     43201 ccatcattta ttaaattgaa aatcctttcc ccattgcttg cttttgtcag gtttctaaaa
     43261 gacagatggt tgtaggtaca atatgcagtt tcttcaagtc atataatacc atctgaaatc
     43321 tcttattaat tcatttcttt tagtatgtat gctggtctcc tctgctcact atagtgaggg
     43381 caccattagc cagagaatct gtctgtctag ttcatgtaag attctcagaa ttaagaaaaa
     43441 tggatggcat atgaatgaaa cttcatggat gacatatgga atctaatgtg tatttgttga
     43501 attaatgcat aagatgcaac aagggaaagg ttgacaactg cagtgataac ctggtattga
     43561 tgatataaga gtctatagat cacagtagaa gcaataatca tggaaaacaa ttggaaatgg
     43621 ggaacagcca caaacaagaa agaatcaata ctaccaggaa agtgactgca ggtcactttt
     43681 cctggagcgg gtgagagaaa agtggaagtt gcagtaactg ccgaattcct ggttggctga
     43741 tggaaagatg gggcaactgt tcactggtac gcagggtttt agatgtatgt acctaaggat
     43801 atgaggtatg gcaatgaaca gaaattcttt tgggaatgag ttttagggcc attaaaggac
     43861 atgacctgaa gtttcctctg aggccagtcc ccacaactca atataaatgt gtttcctgca
     43921 tatagtcaaa gttgccactt ctttttcttc atatcatcga tctctgctct taaagataat
     43981 cttggttttg cctcaaactg tttgtcacta caaactttcc ccatgttcct aagtaaaaca
     44041 ggtaactgcc tctcaactat atcaagtaga ctaaaatatt gtgtctctaa tatcagaaat
     44101 tcagctttaa tatattgggt ttaactcttt gaaatttaga gtctccttga aatacacatg
     44161 ggggtgattt cctaaacttt atttcttgta aggatttatc tcaggggtaa cacacaaacc
     44221 agcatcctga acctctaagt atgaggacag taagccttaa gaatataaaa taaactgttc
     44281 ttctctctgc cggtggaagt gtgccctgtc tattcctgaa attgcttgtt tgagacgcat
     44341 gagacgtgca gcacatgaga cacgtgcagc agcctgtgga atattgtcag tgaagaatgt
     44401 ctttgcctga ttagatataa agacaagtta aacacagcat tagactatag atcaagcctg
     44461 tgccagacac aaatgaccta atgcccagca cgggccacgg aatctcctat cctcttgctt
     44521 gaacagagca gcacacttct cccccaacac tattagatgt tctggcataa ttttgtagat
     44581 atgtaggatt tgacatggac tattgttcaa tgattcagag gaaatctcct ttgttcagat
     44641 aagtacactg actactaaat ggattaaaaa acacagtaat aaaacccagt tttcccctta
     44701 cttccctagt ttgtttctta ttctgctttc ttccaagttg atgctggata gaggtgttta
     44761 tttctattct aaaaagtgat gaaattggcc gggcgcggtg gctcacacct gtaatcccag
     44821 cactttggga ggctgaggtg ggcggatcac gaggtcagga gatcaagacc atcctggcta
     44881 acatggtgaa accccatctc tactaaaaat acaaaaaatt agccagagac ggtggcgggt
     44941 gcctgtagtc ccagctactc gggaggctga ggcaggagaa tggcgtgaac ctgggaggca
     45001 gagctgcagt gagcagagat cgcgccactg cacactccag cctgggtgac aaagcgagac
     45061 tccatctcaa aaaaaaaaaa aaaaaaaaaa agaaagaaag aaagaaaaaa aaagtgatga
     45121 aattgtgtat tcaatgtagt ctcaagagaa ttgaaaacca agaaaggctg tggcttcttc
     45181 cacataaagc ctggatgaat aacaggataa cacgttgtta cattgtcaca actcctgatc
     45241 caggaattga tggctaagat attcgtaatt cttatccttt tcagttgtaa cttattccta
     45301 tttgtcagca ttcaggttat tagcggctgc tggcgaagtc cttgagaaat aaactgcaca
     45361 ctggatggtg ggggtagtgt aggaaaatgg aggggaagga agtaaagttt caaattaagc
     45421 ctgaacagca aagttcccct gagaaggcca cctggattct atcagaaact cgaatgtcca
     45481 tcttgcaaaa cttccttgcc caaaccccac ccctggagtc acaacccacc cttgaccaat
     45541 agattcattt cactgaggga ggcaaagggc tggtcaatag attcatttca ctgggagagg
     45601 caaagggctg ggggccagag aggagaagta aaaagccaca catgaagcag caatgcaggc
     45661 atgcttctgg ctcatctgtg atcaccagga aactcccaga tctgacactg tagtgcattt
     45721 cactgctgac aagaaggctg ctgccaccag cctgtgaagc aaggttaagg tgagaaggct
     45781 ggaggtgaga ttctgggcag gtaggtactg gaagccggga caaggtgcag aaaggcagaa
     45841 agtgtttctg aaagagggat tagcccgttg tcttacatag tctgactttg cacctgctct
     45901 gtgattatga ctatcccaca gtctcctggt tgtctaccca tggacctaga ggtactttga
     45961 aagttttgga tatctgggct ctgactgtgc aataatgggc aaccccaaag tcaaggcaca
     46021 tggcaagaag gtgctgatct ccttcggaaa agctgttatg ctcacggatg acctcaaagg
     46081 cacctttgct acactgagtg acctgcactg taacaagctg cacgtggacc ctgagaactt
     46141 cctggtgagt agtaagtaca ctcacgcttt cttctttacc cttagatatt tgcactatgg
     46201 gtacttttga aagcagaggt ggctttctct tgtgttatga gtcagctatg ggatatgata
     46261 tttcagcagt gggattttga gagttatgtt gctgtaaata acataactaa aatttggtag
     46321 agcaaggact atgaataatg gaaggccact taccatttga tagctctgaa aaacacatct
     46381 tataaaaaat tctggccaaa atcaaactga gtgttttgga tgagggaaca gaagttgaga
     46441 tagagaaaat aacatctttc ctttggtcag cgaaattttc tataaaaatt aatagtcact
     46501 tttctgcata gtcctggagg ttagaaaaag atcaactgaa caaagtagtg ggaagctgtt
     46561 aaaagaggat tgtttccctc cgaatgatga tggtatactt ttgtacgcat ggtacaggat
     46621 tctttgttat gagtgtttgg gaaaattgta tgtatgtatg tatgtatgtg atgactgggg
     46681 acttatccta tccattactg ttccttgaag tactattatc ctacttttta aaaggacgaa
     46741 gtctctaaaa aaaaaatgaa acaatcacaa tatgttgggg tagtgagttg gcatagcaag
     46801 taagagaagg ataggacaca atgggaggtg cagggctgcc agtcatattg aagctgatat
     46861 ctagcccata atggtgagag ttgctcaaac tctggtcaaa aaggatgtaa gtgttatatc
     46921 tatttactgc aagtccagct tgaggccttc tattcactat gtaccatttt cttttttatc
     46981 ttcactccct ccccagctct taggcaacgt gatattgatt gttttggcaa cccacttcag
     47041 cgaggatttt accctacaga tacaggcttc ttggcagtaa ctaacaaatg ctgtggttaa
     47101 tgctgtagcc cacaagacca ctgagttccc tgtccactat gtttgtacct atgtcccaaa
     47161 atctcatctc ctttagatgg gggaggttgg ggagaagagc agtatcctgc ctgctgattc
     47221 agttcctgca tgataaaaat agaataaaga aatatgctct ctaagaaata tcattgtact
     47281 ctttttctgt ctttatattt taccctgatt cagccaaaag gacgcactat ttctgatgga
     47341 aatgagaatg ttggagaatg ggagtttaag gacagagaag atactttctt gcaatcctgc
     47401 aagaaaagag agaactcgtg ggtggattta gtggggtagt tactcctagg aaggggaaat
     47461 cgtctctaga ataagacaat gtttttacag aaagggaggt caatggaggt actctttgga
     47521 ggtgtaagag gattgttggt agtgtgtaga ggtatgttag gactcaaatt agaagttctg
     47581 tataggctat tatttgtatg aaactcagga tatagctcat ttggtgactg cagttcactt
     47641 ctacttattt taaacaacat attttttatg atttataatg aagtggggat ggggcttcct
     47701 agagaccaat caagggccaa accttgaact ttctcttaac gtcttcaatg gtattaatag
     47761 agaattatct ctaaggcatg tgaactggct gtcttggttt tcatctgtac ttcatctgct
     47821 acctctgtga cctgaaacat atttataatt ccattaagct gtgcatatga tagatttatc
     47881 atatgtattt tccttaaagg atttttgtaa gaactaattg aattgatacc tgtaaagtct
     47941 ttatcacact acccaataaa taataaatct ctttgttcag ctctctgttt ctataaatat
     48001 gtacaagttt tattgttttt agtggtagtg attttattct ctttctatat atatacacac
     48061 acatgtgtgc attcataaat atatacaatt tttatgaata aaaaattatt agcaatcaat
     48121 attgaaaacc actgattttt gtttatgtga gcaaacagca gattaaaagg ctgagattta
     48181 ggaaacagca cgttaagtca agttgataga ggagaatatg gacatttaaa agaggcagga
     48241 tgatataaaa ttagggaaac tggatgcaga gaccagatga agtaagaaaa atagctatcg
     48301 ttttgagcaa aaatcactga agtttcttgc atatgagagt gacataataa atagggaaac
     48361 gtagaaaatt gattcacatg tatatatata tatagaactg attagacaaa gtctaacttg
     48421 ggtatagtca gaggagcttg ctgtaattat attgaggtga tggataaaga actgaagttg
     48481 atggaaacaa tgaagttaag aaaaaaaatc gagtaagaga ccattgtggc agtgattgca
     48541 cagaactgga aaacattgtg aaacagagag tcagagatga cagctaaaat ccctgtctgt
     48601 gaatgaaaag aaggaaattt attgacagaa cagcaaatgc ctacaagccc cctgtttgga
     48661 tctggcaatg aacgtagcca ttctgtggca atcacttcaa actcctgtac ccaagaccct
     48721 taggaagtat gtagcaccct caaacctaaa acctcaaaga aagaggtttt agaagatata
     48781 ataccctttc ttctccagtt tcattaatcc caaaacctct ttctcaaagt atttcctcta
     48841 tgtgtccacc ccaaagagct cacctcacca tatctcttga gtgggagcac atagataggc
     48901 ggtgctacca tctaacagct tctgaaattc ctttgtcata tttttgagtc cccactaata
     48961 acccacaaag cagaataaat accagttgct catgtacaat aatcactcaa ctgctgtctt
     49021 gtagcataca ttaattaagc acattctttg aataattact gtgtccaaac aatcacactt
     49081 taaaatctca cacttgtgct atcccttgcc cttctgaatg tcactctgta ttttaaatga
     49141 agagatgagg gttgaatttc ctgtgttact tattgttcat ttctcgatga ggagttttca
     49201 cattcacctt tactggaaaa cacataagta cacatcttac aggaaaaata taccaaactg
     49261 acatgtagca tgaatgcttg tgcatgtagt catataaaat cttgtagcaa tgtaaacatt
     49321 ctctgatata cacatacaga tgtgtctata tgtctacaca atttcttatg ctccatgaac
     49381 aaacattcca tgcacacata agaacacaca ctgttacaga tgcatacttg agtgcattga
     49441 caaaattacc ccagtcaatc tagagaattt ggatttctgc atttgactct gttagctttg
     49501 tacatgctgt tcatttactc tgggtgatgt ctttccctca ttttgccttg tctatcttgt
     49561 actcatactt taagtcctaa cttatatgtt atctcaacta agaagctatt tttttttaat
     49621 tttaactggg cttaaagccc tgtctataaa ctctgctaca attatgggct ctttcttata
     49681 atatttagtg tttttcctac taatgtactt aatctgctca ttgtatattc ctaccactaa
     49741 attttaacct cttttatggt agagacattg tcttgtaaac tcttatttcc ctagtatttg
     49801 gagatgaaaa aaaagattaa attatccaaa attagatctc tcttttctac attatgagta
     49861 ttacactatc catagggaag tttgtttgag acctaaactg aggaaccttt ggttctaaaa
     49921 tgactatgtg atatcttagt atttataggt catgaggttc cttcctctgc ctctgctata
     49981 gtttgattag tcagcaagca tgtgtcatgc atttattcac atcagaattt catacactaa
     50041 taagacatag tatcagaagt cagtttatta gttatatcag ttagggtcca tcaaggaaag
     50101 gacaaaccat tatcagttac tcaacctaga attaaataca gctcttaata gttaattatc
     50161 cttgtattgg aagagctaaa atatcaaata aaggacagtg cagaaatcta gatgttagta
     50221 acatcagaaa acctcttccg ccattaggcc tagaagggca gaaggagaaa atgtttatac
     50281 caccagagtc cagaaccaga gcccataacc agaggtccac tggattcagt gagctagtgg
     50341 gtgctccttg gagagagcca gaactgtcta atgggggcat caaagtatca gccataaaaa
     50401 accataaaaa agactgtctg ctgtaggaga tccgttcaga gagagagaga gaccagaaat
     50461 aatcttgctt atgctttccc tcagccagtg tttaccattg cagaatgtac atgcgactga
     50521 aagggtgagg aaacctggga aatgtcagtt cctcaaatac agagaacact gagggaagga
     50581 tgagaaataa atgtgaaagc agacatgaat ggtaattgac agaaggaaac taggatgtgt
     50641 ccagtaaatg aataattaca gtgtgcagtg attattgcaa tgattaatgt attgataaga
     50701 taatatgaaa acacagaatt caaacagcag tgaactgaga ttagaattgt ggagagcact
     50761 ggcatttaag aatgtcacac ttagaatgtg tctctaggca ttgttctgtg catatatcat
     50821 ctcaatattc attatctgaa aattatgaat taggtacaaa gctcaaataa tttatttttt
     50881 caggttagca agaacttttt tttttttttt ttctgagatg gagcattgct atggttgccc
     50941 aggctggagt gcaatggcat gatccaggct cactgcaaca tctgcctccc aggttcaagc
     51001 gattctcctg cctcagcctc ccaagtagct ggcattacag gcatgtgcca ccaccatgcc
     51061 tggctaattt tctattttta gtagataggg ggtttcacca tgttggtcag gctgatctcg
     51121 aactcctaac atcaggtgat ccaccctcct cggcctctga atgtactggg atcacaggcg
     51181 tgagccacca cacccagcca agaatgtgaa ttttgtagaa ggatataacc catatttctc
     51241 tgaccctaga gtccttagta tacctcccat accatgtggc tcatcctcct tacatacatt
     51301 tcccatcttt caccctacct tttccttttt gtttcagctt ttcactgtgt gtcaaaatct
     51361 agaaccttat ctcctacctg ctctgaaacc aacagcaagt tgacttccat tctaacccac
     51421 attggcatta cactaattaa aatcgatact gagttctaaa atcatctggg attttgggga
     51481 ctatgtctta cttcatactt ccttgagatt tcacattaaa tgttggtgtt cattaaaggt
     51541 ccttcattta actttgtatt catcacactc ttggattcac agttatatct aaactcttat
     51601 atatagcctg tataatccca attcccaagt ctgatttcta acctctgacc tccaacctca
     51661 gtgccaaacc catatatcaa acaatgtact gggcttattt atatagatgt cctataggca
     51721 cctcagactc agcatgggta tttcacttgt tatactaaaa ctgtttctct tccagtgttt
     51781 tccattttag tcattagata gctacttgcc cattcaccaa ggtcacagat taaaatcatt
     51841 tccctacctc taatcaacag ttcaattctg cttcaatttg tccctatcta ttaatcacca
     51901 ctcttactgc ccagtcaggt cctcattgtt tcctgaacaa gagtagatgc tattctttcc
     51961 actttaagac cttatcctgg ctggatgcgg tggctcaggc ttgtaaaccc agcactttgg
     52021 gaggccgagg caggcagatc acttgaggtc aggagttcaa gaccagcctg accaacatgg
     52081 tgaaacccca tctctactaa aaatacaaaa tcagccgggc gtgtggtgca tgcctgcagt
     52141 cccagctatt caggtggctg aggcaggaga attgcttgaa cccaggaggc ggaggttgcg
     52201 gtgagcctag attgcaccat tgcactctag cttgggcaat agggatgaaa ctccatctca
     52261 gaagagaaaa gaaaaaaaga ccttattctg ttacacaaat cctctcaatg caatccatat
     52321 agaataaaca tgtaaccaga tctcccaatg tgtaaaatca tttcaggtag aacagaatta
     52381 aagtgaaaag ccaagtcttt ggaattaaca gacaaagttc aaataacagt cctcatggcc
     52441 ttaagaattt acctaacatt ttttttagaa tcaattttct tatatatgaa ttggaaacat
     52501 aattcctccc tcacaaacac attctaagat tttaaggaga tattgatgaa gtacatcatc
     52561 tgtcattttt aacagttagt ggtagtgatt cacacagcac attatgatct gttcttgtat
     52621 gttctgttcc attctgtatt cttgacctgg ttgtattctt tctgagctcc agatccacat
     52681 atctaagtac atctttttgc attttacaag agtgcataca atacaatgta tccaagactg
     52741 tatttctgat tttatcgtac cactaaactc acaaatgtgg ccctattctt gtgttcacga
     52801 ctgacatcac cgtcatggtc caagtctgat aatagaaatg gcattgtcac tttcttccct
     52861 actgcaacag aagcccagct atttgtctcc cattttctct acttctaaaa tacatttctt
     52921 cactaagtga gaataatctt ttaaagacac aaatcaaacc atgccaccac ctttcttgaa
     52981 ttattcaata tctttcgttg gcttccaggt tacagaaaaa taacttgtaa caaagtttaa
     53041 aggtcattca tggctcctct ctaccctatt ttataacatt tccccttgtg atcagaatct
     53101 caggcacatc atccatcttt ctatatacaa ataaagtcat atagtttgaa ctcacctctg
     53161 gttactttta atcaaccaaa tgctgtaaaa tgcatttgta tcgctacgtg ttaagcagta
     53221 gttgattctt ttcatttctt gttaatattc tattctttga ctataccgta atttatcaat
     53281 tctactgttg gtaagcattt aagtggctac cggtttgagg tttttatgat tattgctgtc
     53341 ataagcattt ctatacatgt ctttggatac acacatgcat gtgtttctga atatctaaaa
     53401 atgtaattgc taggtaatag acttatcaag catccagcat ttgtggatac tattaaaggt
     53461 tttccaaagg ggttatacta ttgtacagtg tcaccaacag agtttgagtt tctattgatc
     53521 catatcacca ccaaaatttg aactgtcagt cttatctctt ctcttgtctc ttttttcctc
     53581 ttttttttcc ttcccttccc ctctcttcgt ttcttttctc tcctcttctc ttctttcctc
     53641 tcttcccttc cctttctctt tctcttccct atcccttctc ctctcctctc ccctcctttt
     53701 ttctcctctc ctctccatta tttatttttc cttcttctcc tccatccctt ccatcctctc
     53761 tcttcccctc ttccttcctt cctttctcca tttcttcctc ctctttccct caatccttcc
     53821 ttttggatat gctcatgggt gtgtatttgt ctgccattgt ggcattattt gaattcagaa
     53881 aagagtgaaa aactactggg atcttcattc tgggtctaat tccacatttt tttttaagaa
     53941 cacactctgt aaaaatgttc tgtactagca tattcccagg aacttcgtta aatttaatct
     54001 ggctgaatat ggtaaatcta ctttgcactt tgcattcttt ctttagtcat accataattt
     54061 taaacattca aaatatttgt atataatatt tgattttatc tgtcattaaa atgttaacct
     54121 taaaattcat gtttccagaa cctatttcaa taactggtaa ataaacacta ttcatttttt
     54181 aaatattctt ttaatggata tttatttcaa tataataaaa aattagagtt ttattatagg
     54241 aagaatttac caaaagaagg aggaagcaag caagtttaaa ctgcagcaat agttgtccat
     54301 tccaacctct caaaattccc ttggagacaa aatctctaga ggcaaagaag aactttatat
     54361 tgagtcaact tgttaaaaca tctgctttta gataagtttt cttagtataa agtgacagaa
     54421 acaaataagt taaactctaa gatacattcc actatattag cctaaaacac ttctgcaaaa
     54481 atgaaactag gaggatattt ttagaaacaa ctgctgaaag agatgcggtg gggagatatg
     54541 cagaggagaa cagggtttct gagtcaagac acacatgaca gaacagccaa tctcagggca
     54601 agttaaggga atagtggaat gaaggttcat ttttcattct cacaaactaa tgaaaccctg
     54661 cttatcttaa accaacctgc tcactggagc agggaggaca ggaccagcat aaaaggcagg
     54721 gcagagtcga ctgttgctta cactttcttc tgacataaca gtgttcacta gcaacctcaa
     54781 acagacacca tggtgcatct gactcctgag gagaagactg ctgtcaatgc cctgtggggc
     54841 aaagtgaacg tggatgcagt tggtggtgag gccctgggca ggttggtatc aaggttataa
     54901 gagaggctca aggaggcaaa tggaaactgg gcatgtgtag acagagaaga ctcttgggtt
     54961 tctgataggc actgactctc tgtcccttgg gctgttttcc taccctcaga ttactggtgg
     55021 tctacccttg gacccagagg ttctttgagt cctttgggga tctgtcctct cctgatgctg
     55081 ttatgggcaa ccctaaggtg aaggctcatg gcaagaaggt gctaggtgcc tttagtgatg
     55141 gcctggctca cctggacaac ctcaagggca ctttttctca gctgagtgag ctgcactgtg
     55201 acaagctgca cgtggatcct gagaacttca gggtgagtcc aggagatgct tcacttttct
     55261 ctttttactt tctaatctta cattttggtt cttttaccta cctgctcttc tcccacattt
     55321 ttgtcatttt actatatttt atcatttaat gcttctaaaa ttttgttaat tttttattta
     55381 aatattctgc attttttcct tcctcacaat cttgctattt taaattattt aatatcctgt
     55441 ctttctctcc caaccccctc ccttcatttt tccttctcta acaacaactc aaattatgca
     55501 taccagctct cacctgctaa ttctgcactt agaataatcc ttttgtctct ccacatgggt
     55561 atgggagagg ctccaactca aagatgagag gcatagaata ctgttttaga ggctataaat
     55621 cattttacaa taaggaataa ttggaatttt ataaattctg tagtaaatgg aatggaaagg
     55681 aaagtgaata tttgattatg aaagactagg cagttacact ggaggtgggg cagaagtcgt
     55741 tgctaggaga cagcccatca tcacactgat taatcaatta atttgtatct attaatctgt
     55801 ttatagtaat taatttgtat atgctatata cacatacaaa attaaaacta atttggaatt
     55861 aatttgtata tagtattata cagcatatat agcatatatg tacatatata gactacatgc
     55921 tagttaagta catagaggat gtgtgtgtat agatatatgt tatatgtatg cattcatata
     55981 tgtacttatt tatgctgatg ggaataacct ggggatcagt tttgtctaag atttgggcag
     56041 aaaaaaatgg gtgttggctc agtttctcag aagccagtct ttatttctct gttaaccata
     56101 tgcatgtatc tgcctacctc ttctccgcag ctcttgggca atgtgctggt gtgtgtgctg
     56161 gcccgcaact ttggcaagga attcacccca caaatgcagg ctgcctatca gaaggtggtg
     56221 gctggtgtgg ctaatgccct ggctcacaag taccattgag atcctggact gtttcctgat
     56281 aaccataaga agaccctatt tccctagatt ctattttctg aacttgggaa cacaatgcct
     56341 acttcaaggg tatggcttct gcctaataaa gaatgttcag ctcaacttcc tgattaattt
     56401 cacttatttc atttttttgt ccaggtgtgt aagaaggttc ctgaggctct acagataggg
     56461 agcacttgtt tattttacaa agagtacatg ggaaaagaga aaagcaaggg aaccgtacaa
     56521 ggcattaatg ggtgacactt ctacctccaa agagcagaaa ttatcaagaa ctcttgatac
     56581 aaagataata ctggcactgc agaggttcta gggaagacct caaccctaag acatagcctc
     56641 aagggtaata gctacgatta aactccaaca attactgaga aaataatgtg ctcaattaaa
     56701 ggcataatga ttactcaaga caatgttatg ttgtctttct tcctccttcc tttgcctgca
     56761 cattgtagcc cataatacta taccccatca agtgttcctg ctccaagaaa tagcttcctc
     56821 ctcttacttg ccccagaaca tctctgtaaa gaatttcctc ttatcttccc atatttcagt
     56881 caagattcat tgctcacgta ttacttgtga cctctcttga ccccagccac aataaacttc
     56941 tctatactac ccaaaaaatc tttccaaacc ctccccgaca ccatattttt atatttttct
     57001 tatttatttc atgcacacac acacactccg tgctttataa gcaattctgc ctattctcta
     57061 ccttcttaca atgcctactg tgcctcatat taaattcatc aatgggcaga aagaaaatat
     57121 ttattcaaga aaacagtgaa tgaatgaacg aatgagtaaa tgagtaaatg aaggaatgat
     57181 tattccttgc tttagaactt ctggaattag aggacaatat taataatacc atcgcacagt
     57241 gtttctttgt tgttaatgct acaacataca aagaggaagc atgcagtaaa caaccgaaca
     57301 gttatttcct ttctgatcat aggagtaata tttttttcct tgagcacatt tttgccatag
     57361 gtaaaattag aaggattttt agaactttct cagttgtata catttttaaa aatctgtatt
     57421 atatgcatgt tgattaattt taaacttact tgaataccta aacagaatct gttgtttcct
     57481 tgtgtttgaa agtgctttca cagtaactct gtctgtactg ccagaatata ctgacaatgt
     57541 gttatagtta actgttttga tcacaacatt ttgaattgac tggcagcaga agctcttttt
     57601 atatccatgt gttttcctta agtcattata catagtaggc atgagactct ttatactgaa
     57661 taagatattt aggaaccact ggtttacata tcagaagcag agctactcag ggcattttgg
     57721 ggaagatcac tttcacattc ctgagcatag ggaagttctc ataagagtaa gatattaaaa
     57781 ggagatactt gtgtggtatt cgaaagacag taagagagat tgtagacctt atgatcttga
     57841 tagggaaaac aaactacatt cctttctcca aaagtcaaaa aaaaagagca aatatagctt
     57901 actatacctt ctattcctac accattagaa gtagtcagtg agtctaggca agatgttggc
     57961 cctaaaaatc caaataccag agaattcatg agaacatcac ctggatggga catgtgccga
     58021 gcaacacaat tactatatgc taggcattgc tatcttcata ttgaagatga ggaggtcaag
     58081 agatgaaaaa agacttggca ccttgttgtt atattaaaat tatttgttag agtagagctt
     58141 ttgtaagagt ctaggagtgt gggagctaaa tgatgataca catggacaca aagaatagat
     58201 caacagacac ccaggcctac ttgagggttg agggtgggaa gagggagacg atgaaaaaga
     58261 acctattggg tattaagttc atcactgagt gatgaaataa tctgtacatc aagacccagt
     58321 gatatgcaat ttacctatat aacttgtaca tgtaccccca aatttaaaat aaagttaaaa
     58381 caaagtatag gaatggaatt aattcctcaa gatttggctt taattttatt tgataattta
     58441 tcaaatggtt gtttttcttt tctcactatg gcgttgcttt ataaactatg ttcagtatgt
     58501 ctgaatgaaa gggtgtgtgt gtgtgtgaaa gagagggaga gaggaaggga agagaggacg
     58561 taataatgtg aatttgagtt catgaaaatt tttcaataaa ataatttaat gtcaggagaa
     58621 ttaagcctaa tagtctccta aatcatccat ctcttgagct tcagagcagt cctctgaatt
     58681 aatgcctaca tgtttgtaaa gggtgttcag actgaagcca agattctacc tctaaagaga
     58741 tgcaatctca aatttatctg aagactgtac ctctgctctc cataaattga caccatggcc
     58801 cacttaatga ggttaaaaaa aagctaattc tgaatgaaaa tctgagccca gtggaggaaa
     58861 tattaatgaa caaggtgcag actgaaatat aaattttctg taataattat gcatatactt
     58921 tagcaaagtt ctgtctatgt tgactttatt gcttttggta agaaatacaa ctttttaaag
     58981 tgaactaaac tatcctattt ccaaactatt ttgtgtgtgt gcggtttgtt tctatgggtt
     59041 ctggttttct tggagcattt ttatttcatt ttaattaatt aattctgaga gctgctgagt
     59101 tgtgtttact gagagattgt gtatctgcga gagaagtctg tagcaagtag ctagactgtg
     59161 cttgacctag gaacatatac agtagattgc taaaatgtct cacttgggga attttagact
     59221 aaacagtaga gcatgtataa aaatactcta gtcaagtgct gcttttgaaa caaatgataa
     59281 aaccacactc ccatagatga gtgtcatgat tttcatggag gaagttaata ttcatcctct
     59341 aagtataccc agactagggc cattctgata taaaacatta ggacttaaga aagattaata
     59401 gactggagta aaggaaatgg acctctgtct ctctcgctgt ctcttttttg aggacttgtg
     59461 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtt gtggtcagtg gggctggaat aaaagtagaa
     59521 tagacctgca cctgctgtgg catccattca cagagtagaa gcaagctcac aatagtgaag
     59581 atgtcagtaa gcttgaatag tttttcagga actttgaatg ctgatttaga tttgaaactg
     59641 aggctctgac cataaccaaa tttgcactat ttattgcttc ttgaaactta tttgcctggt
     59701 atgcctgggc ttttgatggt cttagtatag cttgcagcct tgtccctgca gggtattatg
     59761 ggtaatagaa agaaaagtct gcgttacact ctagtcacac taagtaacta ccattggaaa
     59821 agcaacccct gccttgaagc caggatgatg gtatctgcag cagttgccaa cacaagagaa
     59881 ggatccatag ttcatcattt aaaaaagaaa acaaaataga aaaaggaaaa ctatttctga
     59941 gcataagaag ttgtagggta agtctttaag aaggtgacaa tttctgccaa tcaggatttc
     60001 aaagctcttg ctttgacaat tttggtcttt cagaatacta taaatataac ctatattata
     60061 atttcataaa gtctgtgcat tttctttgac ccaggatatt tgcaaaagac atattcaaac
     60121 ttccgcagaa cactttattt cacatataca tgcctcttat atcagggatg tgaaacaggg
     60181 tcttgaaaac tgtctaaatc taaaacaatg ctaatgcagg tttaaattta ataaaataaa
     60241 atccaaaatc taacagccaa gtcaaatctg tatgttttaa catttaaaat attttaaaga
     60301 cgtcttttcc caggattcaa catgtgaaat cttttctcag ggatacacgt gtgcctagat
     60361 cctcattgct ttagtttttt acagaggaat gaatataaaa agaaaatact taaattttat
     60421 ccctcttacc tctataatca tacataggca taatttttta acctaggctc cagatagcca
     60481 tagaagaacc aaacactttc tgcgtgtgtg agaataatca gagtgagatt ttttcacaag
     60541 tacctgatga gggttgagac aggtagaaaa agtgagagat ctctatttat ttagcaataa
     60601 tagagaaagc atttaagaga ataaagcaat ggaaataaga aatttgtaaa tttccttctg
     60661 ataactagaa atagaggatc cagtttcttt tggttaacct aaattttatt tcattttatt
     60721 gttttatttt attttatttt attttatttt gtgtaatcgt agtttcagag tgttagagct
     60781 gaaaggaaga agtaggagaa acatgcaaag taaaagtata acactttcct tactaaaccg
     60841 actgggtttc caggtagggg caggattcag gatgactgac agggccctta gggaacactg
     60901 agaccctacg ctgacctcat aaatgcttgc tacctttgct gttttaatta catcttttaa
     60961 tagcaggaag cagaactctg cacttcaaaa gtttttcctc acctgaggag ttaatttagt
     61021 acaaggggaa aaagtacagg gggatgggag aaaggcgatc acgttgggaa gctatagaga
     61081 aagaagagta aattttagta aaggaggttt aaacaaacaa aatataaaga gaaataggaa
     61141 cttgaatcaa ggaaatgatt ttaaaacgca gtattcttag tggactagag gaaaaaaata
     61201 atctgagcca agtagaagac cttttcccct cctaccccta ctttctaagt cacagaggct
     61261 ttttgttccc ccagacactc ttgcagatta gtccaggcag aaacagttag atgtccccag
     61321 ttaacctcct atttgacacc actgattacc ccattgatag tcacactttg ggttgtaagt
     61381 gactttttat ttatttgtat ttttgactgc attaagaggt ctctagtttt ttatctcttg
     61441 tttcccaaaa cctaataagt aactaatgca cagagcacat tgatttgtat ttattctatt
     61501 tttagacata atttattagc atgcatgagc aaattaagaa aaacaacaac aaatgaatgc
     61561 atatatatgt atatgtatgt gtgtatatat acacatatat atatatattt tttttctttt
     61621 cttaccagaa ggttttaatc caaataagga gaagatatgc ttagaactga ggtagagttt
     61681 tcatccattc tgtcctgtaa gtattttgca tattctggag acgcaggaag agatccatct
     61741 acatatccca aagctgaatt atggtagaca aagctcttcc acttttagtg catcaatttc
     61801 ttatttgtgt aataagaaaa ttgggaaaac gatcttcaat atgcttacca agctgtgatt
     61861 ccaaatatta cgtaaataca cttgcaaagg aggatgtttt tagtagcaat ttgtactgat
     61921 ggtatggggc caagagatat atcttagagg gagggctgag ggtttgaagt ccaactccta
     61981 agccagtgcc agaagagcca aggacaggta cggctgtcat cacttagacc tcaccctgtg
     62041 gagccacacc ctagggttgg ccaatctact cccaggagca gggagggcag gagccagggc
     62101 tgggcataaa agtcagggca gagccatcta ttgcttacat ttgcttctga cacaactgtg
     62161 ttcactagca acctcaaaca gacaccatgg tgcacctgac tcctgaggag aagtctgccg
     62221 ttactgccct gtggggcaag gtgaacgtgg atgaagttgg tggtgaggcc ctgggcaggt
     62281 tggtatcaag gttacaagac aggtttaagg agaccaatag aaactgggca tgtggagaca
     62341 gagaagactc ttgggtttct gataggcact gactctctct gcctattggt ctattttccc
     62401 acccttaggc tgctggtggt ctacccttgg acccagaggt tctttgagtc ctttggggat
     62461 ctgtccactc ctgatgctgt tatgggcaac cctaaggtga aggctcatgg caagaaagtg
     62521 ctcggtgcct ttagtgatgg cctggctcac ctggacaacc tcaagggcac ctttgccaca
     62581 ctgagtgagc tgcactgtga caagctgcac gtggatcctg agaacttcag ggtgagtcta
     62641 tgggaccctt gatgttttct ttccccttct tttctatggt taagttcatg tcataggaag
     62701 gggagaagta acagggtaca gtttagaatg ggaaacagac gaatgattgc atcagtgtgg
     62761 aagtctcagg atcgttttag tttcttttat ttgctgttca taacaattgt tttcttttgt
     62821 ttaattcttg ctttcttttt ttttcttctc cgcaattttt actattatac ttaatgcctt
     62881 aacattgtgt ataacaaaag gaaatatctc tgagatacat taagtaactt aaaaaaaaac
     62941 tttacacagt ctgcctagta cattactatt tggaatatat gtgtgcttat ttgcatattc
     63001 ataatctccc tactttattt tcttttattt ttaattgata cataatcatt atacatattt
     63061 atgggttaaa gtgtaatgtt ttaatatgtg tacacatatt gaccaaatca gggtaatttt
     63121 gcatttgtaa ttttaaaaaa tgctttcttc ttttaatata cttttttgtt tatcttattt
     63181 ctaatacttt ccctaatctc tttctttcag ggcaataatg atacaatgta tcatgcctct
     63241 ttgcaccatt ctaaagaata acagtgataa tttctgggtt aaggcaatag caatatttct
     63301 gcatataaat atttctgcat ataaattgta actgatgtaa gaggtttcat attgctaata
     63361 gcagctacaa tccagctacc attctgcttt tattttatgg ttgggataag gctggattat
     63421 tctgagtcca agctaggccc ttttgctaat catgttcata cctcttatct tcctcccaca
     63481 gctcctgggc aacgtgctgg tctgtgtgct ggcccatcac tttggcaaag aattcacccc
     63541 accagtgcag gctgcctatc agaaagtggt ggctggtgtg gctaatgccc tggcccacaa
     63601 gtatcactaa gctcgctttc ttgctgtcca atttctatta aaggttcctt tgttccctaa
     63661 gtccaactac taaactgggg gatattatga agggccttga gcatctggat tctgcctaat
     63721 aaaaaacatt tattttcatt gcaatgatgt atttaaatta tttctgaata ttttactaaa
     63781 aagggaatgt gggaggtcag tgcatttaaa acataaagaa atgaagagct agttcaaacc
     63841 ttgggaaaat acactatatc ttaaactcca tgaaagaagg tgaggctgca aacagctaat
     63901 gcacattggc aacagccctg atgcctatgc cttattcatc cctcagaaaa ggattcaagt
     63961 agaggcttga tttggaggtt aaagttttgc tatgctgtat tttacattac ttattgtttt
     64021 agctgtcctc atgaatgtct tttcactacc catttgctta tcctgcatct ctcagccttg
     64081 actccactca gttctcttgc ttagagatac cacctttccc ctgaagtgtt ccttccatgt
     64141 tttacggcga gatggtttct cctcgcctgg ccactcagcc ttagttgtct ctgttgtctt
     64201 atagaggtct acttgaagaa ggaaaaacag ggggcatggt ttgactgtcc tgtgagccct
     64261 tcttccctgc ctcccccact cacagtgacc cggaatctgc agtgctagtc tcccggaact
     64321 atcactcttt cacagtctgc tttggaagga ctgggcttag tatgaaaagt taggactgag
     64381 aagaatttga aagggggctt tttgtagctt gatattcact actgtcttat taccctatca
     64441 taggcccacc ccaaatggaa gtcccattct tcctcaggat gtttaagatt agcattcagg
     64501 aagagatcag aggtctgctg gctcccttat catgtccctt atggtgcttc tggctctgca
     64561 gttattagca tagtgttacc atcaaccacc ttaacttcat ttttcttatt caatacctag
     64621 gtaggtagat gctagattct ggaaataaaa tatgagtctc aagtggtcct tgtcctctct
     64681 cccagtcaaa ttctgaatct agttggcaag attctgaaat caaggcatat aatcagtaat
     64741 aagtgatgat agaagggtat atagaagaat tttattatat gagagggtga aacctaaaat
     64801 gaaatgaaat cagacccttg tcttacacca taaacaaaaa taaatttgaa tgggttaaag
     64861 aattaaacta agacctaaaa ccataaaaat ttttaaagaa atcaaaagaa gaaaattcta
     64921 atattcatgt tgcagccgtt ttttgaattt gatatgagaa gcaaaggcaa caaaaggaaa
     64981 aataaagaag tgaggctaca tcaaactaaa aaatttccac acaaaaaaga aaacaatgaa
     65041 caaatgaaag gtgaaccatg aaatggcata tttgcaaacc aaatatttct taaatatttt
     65101 ggttaatatc caaaatatat aagaaacaca gatgattcaa taacaaacaa aaaattaaaa
     65161 ataggaaaat aaaaaaatta aaaagaagaa aatcctgcca tttatgcgag aattgatgaa
     65221 cctggaggat gtaaaactaa gaaaaataag cctgacacaa aaagacaaat actacacaac
     65281 cttgctcata tgtgaaacat aaaaaagtca ctctcatgga aacagacagt agaggtatgg
     65341 tttccagggg ttgggggtgg gagaatcagg aaactattac tcaaagggta taaaatttca
     65401 gttatgtggg atgaataaat tctagatatc taatgtacag catcgtgact gtagttaatt
     65461 gtactgtaag tatatttaaa atttgcaaag agagtagatt tttttgtttt tttagatgga
     65521 gttttgctct tgttgtccag gctggagtgc aatggcaaga tcttggctca ctgcaacctc
     65581 cgcctcctgg gttcaagcaa atctcctgcc tcagcctccc gagtagctgg gattacaggc
     65641 atgcgacacc atgcccagct aattttgtat ttttagtaga gacggggttt ctccatgttg
     65701 gtcaggctga tccgcctcct cggccaccaa agggctggga ttacaggcgt gaccaccggg
     65761 cctggccgag agtagatctt aaaagcattt accacaagaa aaaggtaact atgtgagata
     65821 atgggtatgt taattagctt gattgtggta atcatttcac aaggtataca tatattaaaa
     65881 catcatgttg tacaccttaa atatatacaa tttttatttg tgaatgatac ctcaataaag
     65941 ttgaagaata ataaaaaaga atagacatca catgaattaa aaaactaaaa aataaaaaaa
     66001 tgcatcttga tgattagaat tgcattcttg atttttcaga tacaaatatc catttgactg
     66061 tttactcttt tccaaaacaa tacaataaat tttagcactt tatcttcatt ttccccttcc
     66121 caatctataa ttttatatat atatatttta gatattttgt atagttttac tccctagatt
     66181 ttctagtgtt attattaaat agtgaagaaa tgtttacact tatgtacaaa atgttttgca
     66241 tgcttttctt catttctaac attctctcta agtttattct attttttcct gattatcctt
     66301 aatattatct ctttctgctg gaaatatatt gttacttttg gtttatctaa aaatggcttc
     66361 attttcttca ttctaaaatc atgttaaatt aataccactc atgtgtaagt aagatagtgg
     66421 aataaataga aatccaaaaa ctaaatctca caaaatataa taatgtgata tataaaaata
     66481 tagcttttaa atttagcttg gaaataaaaa acaaacagta attgaacaac tatacttttt
     66541 gaaaagagta aagtgaaatg cttaactgca tataccacaa tcgattacac aattaggtgt
     66601 gaaggtaaaa ttcagtcacg aaaaaactag aataaaaata tgggaagaca tgtatataat
     66661 cttagagata acagtgttat ttaattatca acccaaagta gaaactatca agggagaaat
     66721 aaattcagtc aacaataaaa gcatttaaga agttattcta ggctgggagc ggtggctcac
     66781 acctgcaatt gcagcacttt gggaggccta gacaggcgga tcacgacgtc aggagttcaa
     66841 gatcagcctg gccaacatag tgaaacctca tcgctactaa aaatataaaa acttagcctg
     66901 gcgtggtggc aggcatgtgt aatcccagca atttgggagg ctgaggcagg agaatcgctt
     66961 gatcctggga ggcagaggtt gcagtgagcc aagattgtgc cactgcattc cagcccaggt
     67021 gacagcatga gactccgtca caaaaaaaaa agaaaaaaaa gggggggggg ggcggtggag
     67081 ccaagatgac cgaataggaa cagctccagt ctatagctcc catcgtgagt gacgcagaag
     67141 acgggtgatt tctgcatttc caactgaggt accaggttca tctcacaggg aagtgccagg
     67201 cagtgggtgc aggacagtag tgcagtgcac tgtgcatgag ccgaagcagg gcgaggcatc
     67261 acctcacccg ggaagcacaa ggggtcaggg aattcccttt cctagtcaaa gaaaagggtg
     67321 acagatggca cctggaaaat cgggtcactc ccgccctaat actgcgctct tccaacaagc
     67381 ttaacaaatg gcacaccagg agattatatc ccatgcctgg ctcagagggt cctacgccca
     67441 tggagcctcg ctcattgcta gcacagcagt ctgaggtcaa actgcaaggt ggcagtgagg
     67501 ctgggggagg ggtgcccacc attgtccagg cttgagcagg taaacaaagc cgcctggaag
     67561 ctcgaactgg gtggagccca ccacagctca aggaggcctg cctgcctctg taggctccac
     67621 ctctaggggc agggcacaga caaacaaaag acaacaagaa cctctgcaga cttaaatgtc
     67681 cctgtctgac agctttgaag agagtagtgg ttctcccagc acatagcttc agatctgaga
     67741 acaggcagac tgcctcctca agtgggtccc tgacccccga gtagcctaac tgggaggcat
     67801 cccccagtag ggcggactga cacctcacat ggctggtact cctctaagac aaaacttcca
     67861 gaggaatgat caggcagcag catttgcggt tcaccaatat ccactgttct gcagccaccg
     67921 ctgctgatac ccaggaaaac agcatctgga gtggacctcc agtaaactcc aacagacctg
     67981 cagctgaggg tcctgactgt tagaaggaaa actaacaaac agaaaggaca tccacaccaa
     68041 aaacccatct gtacatcacc atcatcaaag accaaaggta gataaaacca taaagatggg
     68101 gaaaaagcag agcagaaaaa ctggacactc taaaaatgag agtgcctctc cttctccaaa
     68161 gtaacgcagc tcctcaccag caatggaaca aagctgggca gagaatgact ttgacgagtt
     68221 gagagaggaa ggcttcagaa gatcaaacta ctccaagcta aaggaggaag ttcgaacaaa
     68281 cggcaaagaa gtaaaaaact ttgaaaaaaa attagatgaa tggataacta gaataaccaa
     68341 tgcacagaag tccttaaagg acctgatgga gctgaaaacc aaggcaggag aactacgtga
     68401 caaatacaca agcctcagta accgatgaga tcaactggaa gaaagggtat caatgacgga
     68461 agatgaaatg aatgaaatga agcatgaaga gaagtttaga gaaaaaagaa taaaaagaaa
     68521 cgaacaaagc ctccaagaaa tatgggacta tgtgaaaaga ccaaatctac atctaattgg
     68581 tgtagctgaa agtgatgggg agaatggaac caagttggaa aacactctgc aggatattat
     68641 ccaggagaac ttccccaatc tagcaaggca gcccaaattc acattcagga aatacagaga
     68701 acgccacaaa gatactccta gagaaaagca actccaagac acataactga cagattcacc
     68761 aaagttgaaa tgaaggaaaa aatgttaagg gcagccagag agaaaggtcg ggttacccac
     68821 aaagggaagc ccatcagact aacagctgat ctatcggcag aaactctaca agccagaaga
     68881 aagtgggggc caatattcaa cattgttaaa gaaaagaatt ttcggcccag aatttcatat
     68941 ccagccaaac taagcttcat aagcattgga gaaataaaat cctttacaga caagcaaatg
     69001 ctgagagatt ttgtcaccac caggcctgcc ctacaagagc tcctgaagga agcactaaac
     69061 atggaaagga acaactagta tcagccactg caaaaacatg ccaaattgta aacgaccatc
     69121 aaggctagga agaaactgca tcaaggagca aaataaccag ctaacatcat aatgacagga
     69181 tcaaattcat acataacaat actcacctta aatgtaaata ggctaaatgc tccaattaaa
     69241 agacacagac tggcaaattg gataaggagt caagacccat ctgtcgttat gtattcagga
     69301 aacccatctc acgtgcagag acacacatag gctcgaaata aaaggatgga ggaatatcta
     69361 ccaagcaaat ggaaaacaaa aaaaggcagg ggttgcaatc ctagtctctg ataaaacaga
     69421 ttttaaacca acaaagatca aaagagacaa agaaggccat tacataatgg caaagggatc
     69481 tattcaagaa gaagaactaa ctatactaaa tatatatgca cccaatacag gagcacccag
     69541 attcataaaa caagtcctga gtgacctaca aagagactta gatgcccaca caataataat
     69601 gggagacttt aacaccccac tgtcaacatt agacagatca acgagacaga aagttaacaa
     69661 ggatatccag gaattggact cagctctgca ccaagcagac ctaatagaca tctacagaac
     69721 tctccacccc aaatcaacag aatatacatt cttttcagca ccacaccaca cctattccaa
     69781 aactgaccac atagttggaa gtaaagctct cctcagcaaa tgtaaaagaa cagaaactat
     69841 aacaaactgt ctctcagacc acagtgcaat caaactagaa ctcaggatta agaaactcac
     69901 tcaaaaccac tcagctacat ggaaactgaa cagcctgctc ctgaatgact actgggtaca
     69961 taacaaaatg aaggcagaaa taaagatgtt ctttgaaaca acgagaacaa agacacaaca
     70021 caccagaatc tctgagacac attcaaagca gtgtgtagag ggaaatttat agcactaaat
     70081 gcccacaagg gaaagcagga aagatctaaa attgacaccc taacatcaca attaaaaaac
     70141 tagagaagca ggagcaaaca cattcaaaag ctaacagaag acaagaaata actaagatca
     70201 gagcagaagt gaagaagata gagacacaaa aaacccttca aaaaaatcaa tgaatccaga
     70261 agctgttttt ttgaaaagat caacaaaatt gatagactgc tagcaagact aataaagaag
     70321 aaaggggaga agaatcaaat agacgcaata aaaaatgaca cggggtatca ccactgatcc
     70381 cacagaaata caaactaccg tcagagaata ctataaacac ctctacgcaa ataaactaga
     70441 aaatctagaa gaaatggata aattcctcga cacatacact ctgccaagac taaaccagga
     70501 agaagttgta tctctgaata gaccaataac aggctctgaa attgaggcaa taattaatag
     70561 cttatcaacc aaaaaaagtc cgggaccagt aggattcata gccgaattct accagaggta
     70621 caaggaggag ctggtaccat tccttctgaa actattccaa tcaatagaaa aagagggaat
     70681 cctccctaac tcattttatg aggccagcat catcctgata ccaaagcctg acagagacac
     70741 aacaaaaaaa gagaatgtta caccaatatc cttgatgaac atcgatgcaa aaatcctcaa
     70801 taaaatactg gcaaactgaa tccagcagca catcaaaaag cttatcctcc atgatcaagt
     70861 gggcttcatc cctgccatgc aaggctggtt caacatacga aatcaataaa cataatccag
     70921 catataaaca gaaccaaaga cacaaaccat atgattatct caatagatgc agaaaaggcc
     70981 tttgacaaaa ttcaacaatg cttcatgcta aaaactctca ataaattagg tattgatggg
     71041 acatatctca aaataataag agctatctat gacaaaccca cagccaatat catactgagt
     71101 ggacaaaaac tggaagcatt ccctttgaaa actggcacaa ggcagggatg ccctctctca
     71161 ccactcctat tcaacatagt gttggaagtt ctggccaggg caatcaggca ggagaaggaa
     71221 ataaagggca ttcaattagg aaaagaggaa ggtgaaattg tccctgtttg cagatgacat
     71281 gattgtatat ctagaaaacc ccattgtctc agcccaaaat ctccttaagc tgataagcaa
     71341 cttcagcaaa gtctcaggat ataaaatcag tgtgcaaaaa tcacaagtat tcctatgcac
     71401 caataacaga caaacagaga gccaaatcat gagtgaactc ccattcacaa ttgcttcaaa
     71461 gagaataaaa tacctaggaa tccaacttac aagggatgtg aaggacctct tcaaggagaa
     71521 ctacaaacca ctgctcaatg aaataaaaga ggatacaaac aaatggaaga acattccatg
     71581 cttatgggta ggaagaatca tatcgtgaaa atggtcatac tgcccaaggt aatttataga
     71641 ttcaatgcca tccccatcaa gctaccaatg actttcttca cagaactgga aaaaactact
     71701 ttaaagttca tatggaatca aaaaagagcc cacatcacca aggcaatcct aagccaaaag
     71761 aacaaagctg gaggcatcac gctacctgac ttcaaactat actacaatgc tacggtaacc
     71821 aaaacagcat ggtactggta ccaaaacaga gatctagacc aatggaacag aacagagccc
     71881 tcagaaataa tgccgcatat ctacaactat ccgatctttg acaaacctga gagaaacaag
     71941 caatggggaa aggattccct atttaataaa tggtgctggg aaaactggct agccatatgt
     72001 agaaagctga aactggatcc ttccttacac cttatacaaa aattaattca agatggatta
     72061 aagacttaaa cattagacct aaaaccataa aaaccctaga aaaaaaccta ggcaatacca
     72121 ttcaggacat aggcatgggc aaggacttca tgtctaaaac accaaaacga atggcaacaa
     72181 aagacaaaat ggacaaacgg gatctaatta aactaaagag cttctgcaca gctaaagaaa
     72241 ctaccatcag agtgaacagg caacctacaa aatgggagaa aatttttgca atctactcat
     72301 ctgacaaagg gctaatatcc agaatctaca atgaactcaa acaaatttac aagaaaaaac
     72361 aaacaacccc atcaaaaagt gggcaaagga tatgaacaga cacttctcaa aagaagacat
     72421 ttatgtaatc aaaaaacaca tgaaaaaatg ctcatcatca ctagccatca gagaaatgca
     72481 aatcaaaacc acaatgagat accatctcac accagttaga atggcgatca ttaaaaagtc
     72541 aggaaacaac aggtgctgga gaggatgtgg agaaacagga acaactttta cactgttggt
     72601 gggactgtaa actagttcaa ccattgcgga agtcagtgtg gcaattcctc aggaatctag
     72661 aactagaaat accatttgac ccagccatcc cattactggg tagataccca aaggattata
     72721 aatcatgctg ctataaagac acatgcacac gtatgtttat tgcagcacta ttcacaatag
     72781 caaagacttg gaaccaaccc aaatgtccaa caacgataga ttggattaag aaaatgtggc
     72841 acatatacac catggaatac tatgcagcca taaaaaatga tgagttcatg tcctttgtag
     72901 ggacatggat gaagctggaa actatcattc tcagcaaact atcacaagga caataaacca
     72961 aacaccgcat gttctcactc ataggtggga attgaacaat gagaacacat ggacacatga
     73021 agaggaacat cacactctgg ggactgttat ggggtggggg gcaggggcag ggatagcact
     73081 aggagatata cctaatgcta aatgacgagt taatgggtgc agcacaccaa catggcacat
     73141 gtatacatat ataacaaacc tgccgttgtg cacatgtacc ctaaaacttg aagtataata
     73201 ataaaaaaaa gttatcctat taaaactgat ctcacacatc cgtagagcca ttatcaagtc
     73261 tttctctttg aaacagacag aaatttagtg ttttctcagt cagttaac
 //