TUBERCULOSIS COMPONENT
OF
TECHNICAL INSTRUCTIONS
FOR THE
 MEDICAL EXAMINATION
OF ALIENS
IN THE UNITED STATES
May 2008
U.S. DEPARTMENT OF HEALTH & HUMAN SERVICES
Public Health Service
Centers for Disease Control and Prevention
National Center for Preparedness Detection and Control of Infectious Diseases
Division of Global Migration and Quarantine
Atlanta, Georgia 30333
Table of Contents
I.	INTRODUCTION	1
MAJOR CHANGES FROM PREVIOUS TUBERCULOSIS COMPONENT OF TECHNICAL INSTRUCTIONS	1
II.	ROLES OF THE CIVIL SURGEON AND HEALTH DEPARTMENT	1
ROLE OF THE CIVIL SURGEON	1
ROLE OF LOCAL OR STATE HEALTH DEPARTMENT	1
III.	PAST MEDICAL HISTORY	1
REVIEW OF ALL HOSPITALIZATIONS AND INSTITUTIONALIZATIONS	1
REVIEW OF ALL SERIOUS ILLNESSES AND DISABILITIES	1
REVIEW OF PREVIOUS CHEST RADIOGRAPHS, LABORATORY RESULTS, AND TREATMENT RECORDS	1
IV.	REVIEW OF SYMPTOMS AND PHYSICAL EXAMINATION	1
REVIEW OF SYMPTOMS	1
GENERAL PHYSICAL EXAMINATION	1
V.	TB DIAGNOSIS: TESTS AND REFERRALS	1
MANTOUX TST	1
QUANTIFERON-TB GOLD TEST	1
RADIOGRAPHIC EXAMINATION OF THE CHEST	1
REQUIRED REFERRAL TO THE TB CONTROL PROGRAM OF THE LOCAL HEALTH DEPARTMENT	1
RECOMMENDED REFERRAL TO LOCAL HEALTH DEPARTMENT	1
LABORATORY SUPPORT	1
VI.	CLASSIFICATION OF APPLICANTS WITH EVIDENCE OF TB	1
CLASS B1 - EXTRAPULMONARY TUBERCULOSIS, ACTIVE, NON-INFECTIOUS	1
CLASS B - LATENT TB INFECTION NEEDING EVALUATION FOR TREATMENT	1
CLASS B - OTHER CHEST CONDITION (NON-TB)	1
VII.	TREATMENT OF APPLICANTS WITH CLASS A TB DISEASE	1
VIII.	RE-CLASSIFICATION OF PERSONS WITH CLASS A TB AFTER TREATMENT	1
IX.	RESOURCES	1
X.	APPENDICES	1
APPENDIX A  PURIFIED PROTEIN DERIVATIVE STORAGE; TST ADMINISTRATION AND INTERPRETATION 	1
APPENDIX B  RADIOGRAPHIC FINDINGS SUGGESTIVE OF TB OR OTHER DISEASE	1
APPENDIX C  REFERENCE CHARTS	1
  APPENDIX D  FORM I-693 SAMPLE	1
Figures
FIGURE 1. PROCESS FOR CLASSIFYING TB AND OTHER CHEST CONDITIONS.	1
Tables
TABLE 1. REFERRAL TO HEALTH DEPARTMENT TB CONTROL PROGRAM BY CIVIL SURGEON	1
TABLE 2. TB CLASSIFICATIONS AND SUMMARY OF APPROPRIATE RELATED ACTIONS	1
I.	Introduction
Major Changes from Previous Tuberculosis Component of Technical
Instructions
This document replaces the previous version of the Tuberculosis (TB) component of the Technical
Instructions, which was last revised in June 1991.  The instructions in this document supersede all
previous Technical Instructions, updates to the Technical Instructions, and memoranda and letters regarding
the Technical Instructions, as pertains to tuberculosis screening. Highlights of the major changes in this
version of the TB Technical Instructions are as follows:
*	Sputum cultures for M. tuberculosis, and drug susceptibility testing for positive
cultures, are required for applicants with chest radiograph findings suggestive of
active TB disease. These new tests are mandatory in addition to the previously-required
sputum microscopy for acid fast bacteria.
*	Applicants with Class A (either smear or culture positive) TB must complete a full
course of TB treatment. Completion of therapy is required prior to medical clearance
for TB by the civil surgeon, for purposes of this examination and the United States
Immigration and Citizenship Services (USCIS).
*	A chest radiograph is required for all applicants with a tuberculin skin test (TST)
reaction of 5 mm or greater of induration, including pregnant (or possibly
pregnant) women.  Previously, the chest radiograph could be waived for a pregnant
applicant if she had a scar or other evidence of BCG vaccination and denied having any
TB-related symptoms.  This exception is no longer permissible. If the applicant decides to
undergo a radiograph during pregnancy, the possible risks of radiation to the fetus should
be explained to her and informed consent obtained, confirmed by a signed consent form.
If she wishes, the applicant may defer the radiograph until after delivery, but the
civil surgeon cannot sign the medical examination form until the radiograph is
performed and interpreted, and treatment for Class A pulmonary TB disease, if
needed, is completed.
*	A chest radiograph is now required for applicants with a TST reaction of less
than 5 mm of induration (including no induration) who have:
o	Signs or symptoms consistent with active TB disease.
o	Immunosuppression for any reason (e.g., HIV infection; immunosuppressive
therapy equivalent to or greater than 15 mg/day of prednisone for one month or
longer; history of organ transplantation).
*	Definitions of chest radiographic findings that are suggestive of TB disease are
provided to assist the civil surgeon in determining the proper TB classification. These
descriptions are presented in Appendix B.
*	A new TB classification (Class B: Latent TB Infection Needing Evaluation for
Treatment) should be used for all applicants who are recent arrivals to the United States
(less than 5 years) from countries with a high TB prevalence, with a Mantoux TST
reaction of 10 mm or greater of induration, and no evidence of TB disease. See Section V
for other conditions for which referral for evaluation for treatment of latent TB infection
is recommended. The civil surgeon should pro-actively contact the TB Control Program
of the local health department to identify specific sources of treatment for latent TB
infection and make the appropriate referral.
*	Class B3 (consistent with old, healed TB disease) has been eliminated.
*	TST Instructions: Appendix A includes instructions for the proper procedures that
civil surgeons must follow in the storage of purified protein derivative (PPD), and the
administration and interpretation of the TST.
II.	Roles of the Civil Surgeon and Health Department
These roles are summarized here and will be explained in more detail later in the document.
Role of the Civil Surgeon
The United States Citizenship and Immigration Services (USCIS) in the U.S. Department of Homeland
Security designates civil surgeons. Civil surgeons must perform the medical examination according to
the procedures prescribed in the Technical Instructions.  The description of the examination at the
beginning of the I-693 form distributed by USCIS may differ somewhat from these Technical Instructions.
With regard to the medical examination, the Technical Instructions take precedence.
At a minimum, civil surgeons, with respect to TB, should perform the following tasks:
*	Establish a working relationship with the TB Control Program of the local health
department in order to report suspected and confirmed TB cases as mandated by law and
perform required and recommended referrals (pp. 15-16). The I-693 form (Appendix D)
will aid in these referrals.
*	Verify applicant's identity.
The civil surgeon must confirm the applicant's identity by comparing facial appearance
and signature with an official government document containing a recent photograph and
signature, such as a passport, drivers license, or other type of identity card. The
applicants identity must be verified in the same manner when the applicant is referred to
another facility for a chest radiograph or laboratory test.
*	Perform initial examination, including medical history, review of systems, physical
examination, and especially review of previous chest radiographs and TST results. One
exception to the complete medical examination is for refugees, who generally need only
vaccine administration in order to receive medical clearance.  However, if a refugee
entered the United States with a Class A condition, a full medical examination is required,
regardless of whether the Class A condition was initially evaluated after U.S. entry.
*	Administer Mantoux TST (See Appendix A).
A Mantoux TST must be performed on all applicants who are 2 years of age and older, as
well as applicants less than 2 years of age if there is evidence of contact with a person
known to have TB or other reason to suspect TB.
There are two situations in which the TST is not required. Applicants providing written
documentation (with a health-care providers signature) of a TST reaction of 5 mm or
greater of induration or applicants with a history of a severe reaction with blistering to a
prior TST may be excluded from this requirement. Applicants in these two groups must
undergo a chest radiograph.
*	Schedule a return visit for reading the TST in 4872 hours.
*	Schedule a chest radiograph. Applicants with one or more of the following
conditions must have a chest radiograph to evaluate for TB disease:
o	TST reaction of 5 mm or greater of induration.
o	TB signs or symptoms, regardless of size of TST reaction (including 0 mm
reaction).
o	Immunosuppression for any reason (e.g., HIV infection; immunosuppressive therapy
equivalent to or greater than 15 mg/day of prednisone for one month or longer;
history of organ transplantation) regardless of size of TST reaction (including 0 mm
reaction).
The chest radiograph must be performed according to the specifications listed in
Section V.
*	Refer applicants for further evaluation and treatment, if needed.
Civil surgeons must refer applicants with abnormal chest radiographs suggestive of active
or inactive TB disease to the TB Control Program of the local health department for
further evaluation.  In the United States, TB is sufficiently uncommon and its treatment  is
sufficiently complex that only an expert should treat it.  Public health departments have
considerable experience in dealing with such difficult issues as patient non-adherence,
drug resistance, and HIV co-infection and most use directly observed therapy (DOT) to
ensure that people with TB continue their therapy until completion.  For these reasons,
applicants with suspected TB disease should receive their treatment from providers with
considerable experience and expertise with TB patients, such as health departments or
expert clinicians under contract to health departments.
It is recommended that applicants with no evidence of TB disease who are recent arrivals
to the United States (within 5 years) from countries with a high TB prevalence and who
have a TST reaction of 10 mm or greater of induration be referred to the health
department TB Control Program for evaluation for treatment of latent TB infection,
regardless of age. In some circumstances, applicants with a TST reaction of 5 mm or
greater of induration and no evidence of active TB disease should be evaluated for
treatment of latent TB infection (see Section V). Civil surgeons should contact the TB
Control Program of the local health department to ascertain local policies and
procedures for treating such applicants.  In some areas, the TB Control Program
may be able to provide treatment.  In other areas, TB Control Programs may be
able to provide technical assistance and referral to other health-care providers in
the community who agree to evaluate and treat applicants for latent TB infection.
Civil surgeons should educate applicants about the procedures involved in the medical
examination and the necessity for follow-up diagnostic and treatment services that may
need to be carried out in collaboration with the health department TB Control Program.
Applicants should clearly understand what is expected of them and why they may need to
go to a health department for additional diagnostic testing or treatment.  Finally,
applicants should be told that the civil surgeons medical examination cannot be
completed until the results of follow-up evaluation by the health department TB Control
Program are available.
*	Use the TB Reference Charts in Appendix C for a review of risk factors for
progression of TB infection to TB disease, TB signs and symptoms in both adults
and children, and TB classifications.
*	Record examination results on the USCIS I-693 form.
Civil surgeons are responsible for reporting the results of the TB component of the
medical examination and all required tests on the I-693 form (Appendix D).  The
completed form can be either typed or handwritten, but must be clearly legible.  If the
applicant has any TB condition other than Class A TB (defined as smear-positive and/or
culture-positive) disease, the civil surgeon should sign the form in the space provided for
his/her signature after evaluation is completed.
Applicants identified with Class A TB (either smear or culture positive) cannot be
medically cleared until they have completed a recommended course of treatment,
which is a minimum of 6 months in duration.  Once an applicant has completed the TB-
related follow-up requirements, and has been released from the treating physician back to
the civil surgeon, the applicant must sign and date the form in the space provided in the
presence of the civil surgeon.  The civil surgeon should not sign and date the form until
the applicant has met all TB-related follow-up requirements.
Role of Local or State Health Department
Publicly funded TB Control Programs have overall responsibility for planning, implementing, and
evaluating TB prevention and control programs in their respective areas.  By law, civil surgeons must
promptly report all confirmed and suspected TB cases to state or local health departments to ensure that
applicants are started on the appropriate drug regimen and that a thorough contact or source case (for
pediatric applicants)  investigation is initiated.  In addition to case-finding, surveillance, and patient care,
health departments are responsible for reviewing appropriate laws and regulations to support TB control
activities, building networks and coalitions with voluntary and community-based organizations,
providing expert consultation to local institutions and practitioners, developing an overall TB control
strategy, and ensuring adequate funding for staff to carry out TB control objectives.
In regard to the TB evaluation of aliens referred to civil surgeons, health departments may be able to
assist the civil surgeon by:
*	Providing or arranging training for civil surgeons or their staff in the appropriate
technique for administering and reading the TST.
*	Providing or recommending experienced radiology departments and radiologists to
perform and interpret chest radiographs, respectively.
*	Evaluating applicants with abnormal radiographs suggestive of TB disease.
*	Performing or referring mycobacteriology laboratory work (to include smears, cultures,
and drug susceptibility testing) on specimens from applicants with suspected TB.
*	Providing medical management, treatment (including DOT), contact investigation for
applicants found to have infectious TB, and source case investigations for pediatric
cases diagnosed with TB disease.
*	Providing or facilitating the evaluation and treatment of applicants found to have
latent TB infection.
A list of state TB control offices can be found at the Centers for Disease Control and Preventions
(CDC) Division of TB Elimination website: http://www.cdc.gov/tb/pubs/tboffices.htm.  Each state
office can provide TB program contact information for every local health department in its jurisdiction.
III.	Past Medical History
The primary purpose of obtaining past medical history is to assess whether an applicant has:
*	A history consistent with a past episode of TB disease or latent TB infection.
*	Prior exposure to someone with TB disease.
*	A medical condition that increases the likelihood that TB infection will progress to TB
disease.
Review of All Hospitalizations and Institutionalizations
The civil surgeon must obtain a history of each time an applicant was hospitalized or resided in a
nursing home, refugee camp, homeless shelter, jail, or prison.  It is important to ascertain the
reasons for each hospitalization, especially if it was due to a pulmonary condition such as TB or
pneumonia.  Residence in crowded conditions, such as in the places noted above, can increase a
persons risk of becoming infected and eventually developing TB disease.
Review of All Serious Illnesses and Disabilities
The civil surgeon must ask the applicant whether he or she has ever been diagnosed with or treated for
TB infection or disease.  Any applicant who has had TB infection or disease previously must also be
questioned about the date and place of diagnosis, treatment method (self-administered or DOT),
specific drugs prescribed, duration of treatment, whether treatment was considered successful, and the
criteria for documentation of success.
The civil surgeon must question each applicant about any previous medical history of prolonged illness
or disability, especially respiratory disease.  The applicant must also be questioned about risk factors that
increase the likelihood that latent TB infection will progress to disease.  These include:
*	HIV infection
*	Recent infection with Mycobacterium tuberculosis (within the past 2 years), particularly in
infants and young children
*	Medical conditions  known to increase the risk for disease if infection occurs
*	Injection of  illicit drugs or use of other high-risk substances
*	A history of inadequately treated TB
*	Chest radiograph findings suggestive of previous TB
Review of Previous Chest Radiographs, Laboratory Results, and
Treatment Records
If an applicant indicates a prior history of TB disease, the civil surgeon must make every effort to obtain
and review previous chest radiographs and laboratory and treatment records. Prior chest radiographs
provide an important baseline to compare with the current radiograph. Laboratory records may indicate
the severity and length of disease, as well as drug susceptibility. The treatment records can provide
information on the adequacy of previous treatment and the likelihood of cure. If the applicant was
previously diagnosed with TB disease in the United States, the civil surgeon should contact the
appropriate state or local health department for a copy of the applicants medical records.
IV.	Review of Symptoms and Physical Examination
Review of Symptoms
Most patients with TB disease will have one or more symptoms.  TB symptoms are gradual in onset
and can last from weeks to months.  However, the absence of symptoms does not preclude the
diagnosis of TB disease.  The civil surgeon must ask specifically about all of the following signs
and symptoms:
Generalized or Systemic Signs and Symptoms.  These include fever, chills, night sweats, fatigue,
loss of appetite, and weight loss.
Pulmonary Signs and Symptoms.  It is critical to identify pulmonary TB disease, because it can be
transmissible and therefore is of key importance to the publics health.  Pulmonary signs and
symptoms can include one or more of the following:
*	Prolonged cough (3 or more weeks) with or without sputum production.
*	Hemoptysis (blood in sputum).
*	Pleuritic (inspiratory) chest pain.
Signs and Symptoms of Extrapulmonary TB disease.  Approximately 15% to 20% of TB cases
reported in the United States are solely extrapulmonary.  The civil surgeon should consider
extrapulmonary TB in the differential diagnosis of ill applicants who have systemic symptoms and who
are at high risk for TB. This condition can be more challenging to diagnose because signs and symptoms
are specific to the site of the disease.  For example, TB of the spine can cause back pain, TB of the
kidney can cause blood in the urine, and TB of the lymph nodes can result in lymphadenopathy
(enlargement of the lymph nodes, which may be painful if enlargement occurs rapidly). The majority of
persons with extrapulmonary TB have concurrent pulmonary TB.
Signs and Symptoms in Children. The clinical expression of disease caused by TB is different in
children than in adults. In children, clinical manifestations can be minimal, and range from more
generalized findings, such as fever, night sweats, growth delay, and weight loss, to more specific findings
such as cough and dyspnea (difficulty breathing). Children are more prone to extrapulmonary TB, such
as meningitis, and disease of the middle ear and mastoid, lymph nodes, bones, joints, and skin. These are
examples of pediatric signs and symptoms:
*	Generalized: Failure to thrive, malnutrition, weight loss, lethargy, pallor, night sweats,
fever, tachycardia (rapid heart rate).
*	Pulmonary: cough, tachypnea (rapid respiratory rate), dyspnea, wheezing.
*	Extrapulmonary: meningeal signs, lymphadenopathy (cervical, axillary), splenomegaly
(enlarged spleen), hepatomegaly (enlarged liver).
General Physical Examination
The civil surgeon should conduct a complete physical examination of each applicant to evaluate for TB
disease or a condition that might increase the risk of progression from infection to disease, if infected.
The result of the physical examination, by itself, cannot confirm or exclude TB, but it can provide
valuable information about an applicants overall condition and other factors that may affect TB
treatment, if treatment proves necessary.
General Appearance. An applicant with TB can be ill-appearing, ashen or pale, have wasting of
muscles or unexplained weight loss, or appear well.
Directed Physical Examination.  The civil surgeon must conduct a physical examination of the
applicants respiratory system ((oral pharynx and chest) to evaluate for findings consistent with
pulmonary TB as well as other factors that need be taken into consideration during treatment. In a
patient with pulmonary TB disease, the examination of the chest could reveal:
*	Signs of consolidation, such as flatness or dullness to percussion, crackles, asymmetric
breath sounds, increased vocal resonance (bronchophony, whispered pectoriloquy, and
egophony), or increased tactile fremitus.
*	Evidence of pleural effusion, such as dullness to percussion, decreased  breath sounds,
and decreased tactile vocal fremitus.
Other areas should also be examined to evaluate for evidence of extrapulmonary TB (such as
lymphadenopathy or spinal tenderness and deformity).
V.	TB Diagnosis: Tests and Referrals
Mantoux TST
The purpose of the TST is to identify applicants infected with M. tuberculosis so they can be further
evaluated for active disease. The Mantoux method is the standard, most reliable TST, and is required
for this examination.  Multiple puncture tests (e.g., Tine or Heaf) are not acceptable and are not to be
used for this examination.
Proficiency in applying and reading the TST requires training and ongoing, continual practice. One
study of civil surgeon practices in several areas of the country revealed lower than expected tuberculin
positive rates (average 16%),  among persons born outside the United States who were applying for legal
permanent residence, compared with 35% to 53% in previous studies. The study also revealed that
tuberculin positive rates varied by civil surgeon and by area, for people from the same country and with
the same demographic characteristics. (Saraiya M, Cookson ST, Tribble P, et al. Tuberculosis screening
among foreign-born persons applying for permanent US residence. American Journal of Public Health
2002; 92(5): 826-9.) These findings suggest that difficulties with the proper administration and
interpretation of the TST could cause the unexpectedly low rates of tuberculin positive rates.
The actual technique for administering and reading the TST is relatively simple, yet it must be carried
out meticulously to yield meaningful results (see Appendix A).  All health care workers who administer
and read the TST must be formally trained in the proper technique. The administration and
interpretation of the TST can be delegated to a trained health-care worker, but the civil surgeon is
responsible for the test results and must continually ensure that the worker has been sufficiently trained
and remains proficient.  The civil surgeon can contact his or her local or state health department TB
Control Program for assistance in assessing staff proficiency in skin testing and in providing or arranging
for training. See Appendix A for information on how to order the free Mantoux Tuberculin Skin
Test Training Materials Kit (videotape, facilitator guide, ruler) available from CDC.
People for Whom a TST is Required and Specific Exceptions to the TST
1.	A TST must be performed on all applicants 2 years of age or older, regardless of pregnancy
or previous immunization with BCG vaccine.  There are two exceptions:
*	Applicants who have written documentation of a previous TST reaction of 5 mm or
greater of induration (with the signature of a health-care provider) need not be retested.
In such a case, the applicant will need a chest radiograph to evaluate for TB disease. A
verbal history of a positive TST reaction from the applicant is not acceptable.
*	Applicants who report a severe reaction with blistering secondary to previous tuberculin
skin testing need not be retested. In such a case, the applicant will need a chest radiograph
to evaluate for TB disease.
If the TST is not administered for one of these two reasons, the civil surgeon should not
check the box next to Tuberculin Skin Test in Part 2, Section 2A of the I-693 form. Instead,
the civil surgeon should clearly state the reason for the exception in the Remarks portion of
Section 2A.
If either exception exists, the civil surgeon should follow the recommendations and
requirements for referral of applicants to the health department (in Table I of this section)
based on the prior skin test result and the current chest radiograph reading.
      2.   Applicants younger than 2 years of age are required to have a tuberculin skin test if there
is evidence of contact with a person known to have TB or other reason to suspect TB.
Bacille Calmette-Gurin (BCG) Vaccination and TST
*	Because most applicants have lived in areas where TB transmission is common, the civil
surgeon must perform the TST on all applicants, regardless of a history or evidence of BCG
vaccination, unless one of the two exceptions to TST administration previously noted exists.
*	There are several reasons for assuming that a large reaction (10 mm or greater of induration) to
tuberculin is not due to BCG vaccination:
1.	Tuberculin test conversion rates after BCG vaccination may be much less than 100%.
2.	Tuberculin sensitivity tends to wane over time after the vaccination.
3.	The mean reaction size among vaccinated persons is often less than 10 mm of
induration.
*	Because many BCG-vaccinated applicants have lived in areas of the world where TB
transmission frequently occurs, perform a chest radiograph on all such applicants with a skin
test reaction of 5 mm or greater of induration.
Administration and Interpretation of the TST
Details regarding the proper procedures to be followed in administering and interpreting the TST
are provided in Appendix A.
QuantiFERON-TB Gold Test
The QuantiFERON-TB Gold (QFT-G) test is a recently introduced blood test that has been
approved by the Food and Drug Administration as an aid for detecting M. tuberculosis infection. The
assay measures a component of cell-mediated immune reactivity to M. tuberculosis in fresh whole blood.
It requires only one visit to the doctor, can be completed faster than a skin test, and is less subject to
reader bias and error.  However, the role of QFT-G in targeted testing has not yet been fully defined
and the test currently requires laboratory capability that is not widely available (Centers for Disease
Control and Prevention. Guidelines for Using the QuantiFERON-TB Gold Test for Detecting
Mycobacterium tuberculosis Infection, United States. MMWR 2005; 54[No. RR-15]:49-55.) When changes
to these guidelines occur, an update will be posted at http://www.cdc.gov/ncidod/dq/updates.htm.
Radiographic Examination of the Chest
Applicants for Whom a Chest Radiograph Is Required
A chest radiograph is required for all applicants who:
*	Have a TST reaction of 5 mm or greater of induration.
*	Are immunosuppressed, regardless of the TST result, including those who are:
o	HIV infected
o	Receiving the equivalent of 15 mg/day or more of prednisone for at least one
month
o	Have a history of organ transplantation.
*	Have signs or symptoms of active TB disease, regardless of the TST result.
Chest radiographs are of critical importance in the diagnosis of TB, because pulmonary TB, the most
common form of the disease, is transmissible.  Although findings on a single radiograph cannot confirm
the diagnosis of TB, they do determine the need for further evaluation by the local health department
TB Control Program.
A chest radiograph is required for all applicants with a tuberculin skin test (TST) reaction of 5 mm
or greater of induration, including pregnant (or possibly pregnant) women.  Previously, the chest
radiograph could be waived for a pregnant applicant if she had a scar or other evidence of BCG
vaccination and denied having any TB-related symptoms.  This exception is no longer permissible. If
the applicant decides to undergo a radiograph during pregnancy, the possible risks of radiation to
the fetus should be explained to her and informed consent obtained, confirmed by a signed consent
form. If she wishes, the applicant may defer the radiograph until after delivery, but the civil surgeon
cannot sign the medical examination form until the radiograph is performed and interpreted, and
treatment for Class A pulmonary TB disease, if needed, is completed.
The purposes of the chest radiograph are to:
*	Determine if there are findings suggestive of active or inactive pulmonary TB disease
(e.g., cavities, infiltrates, effusions, nodules, or linear opacities).
*	Evaluate for pulmonary TB disease in a person who has evidence of extrapulmonary
TB disease.
*	Check for any other abnormalities in the thorax, such as cardiomegaly (an enlarged
heart).
Prior to the chest radiograph, the civil surgeon should:
*	Instruct the applicant to bring all previous chest radiographs to the civil surgeons office
for comparison with the current study.
*	Examine all available previous chest radiographs and reports for any evidence suggestive
of past TB disease or other conditions that might increase the risk of progression from
latent TB infection to TB disease (e.g., silicosis).
*	Indicate on the chest radiograph requisition that there is a high suspicion for TB, include
pertinent information based on review of prior radiographs and reports, and send prior
radiographs and reports for comparison, to the physician interpreting the current study
*	Order a PA view for applicants ? 10 years of age. Frontal (AP or PA) and lateral views are
required for children aged 2 through 9 years. If radiographs are obtained on children less
than 2 years of age, frontal and lateral views are also required. Additional views (e.g.,
coned apical lordotic, or a lateral view in adults) may be obtained as necessary.
The radiographer (radiology technologist) should:
*	Verify the applicant's identity by comparing facial appearance and signature with an
official government document that contains the applicants recent photograph and
signature.
*	Protect the gonads of all applicants under 55 years of age, male and female, with wrap-
around lead shielding.
*	Ask female applicants of childbearing age about the date of the first day of the last
menstrual period and about possible pregnancy. If needed, follow the instructions for
pregnant applicants on the previous page, and provide shielding as noted below.
*	Protect the abdomen and pelvis of pregnant women undergoing chest radiographs
with double-layer, wrap-around lead shields.
Requirements for the Standard Frontal Chest Radiograph
*	The film size must be large enough to include the entire thorax, including both lung
apices and costophrenic angles. For digital images printed on film, the image size must
be set at 100%.
*	Ten posterior rib sets, visible through the lungs, indicate sufficient inspiration.
*	The level of penetration should be set so that 1) the lung markings behind the heart can
be visualized by the reader, 2) the lung markings elsewhere in the lung are visible without
a hot light, and (3) the thoracic spine disc spaces are barely apparent.
*	The applicants name, plus the facility name and date of examination, must be
permanently affixed to the film.
*	Photofluorograms are not acceptable.
Interpretation of the Chest Radiograph
*	Previous chest radiographs should be obtained, if available, and compared with the
current study.
*	 The study should be interpreted by a radiologist or other qualified physician who is
trained and experienced in reading chest radiographs demonstrating TB or other diseases
of the lung.
*	The radiograph should be read with a high suspicion for TB.
*	The film quality should be assessed with emphasis on patient positioning, level of
penetration, and presence of artifacts.  The presence of any artifacts, including those
associated with the film, cassette, processor, or clothing, should be noted because these
factors can reduce the discriminative value of the film.
*	Chest radiographs not of sufficient diagnostic quality must be repeated.
Specific descriptions of the radiographic findings can be found in Appendix B. Please note that the
radiographic presentation of children with pulmonary TB can be quite distinct from that of adults.
Required Referral to the TB Control Program of the Local Health
Department
All applicants with an abnormal chest radiograph suggestive of active or inactive TB disease
should be referred to the TB Control Program of the local health department for further evaluation.
Applicants with clinical signs or symptoms suggestive of TB disease should also be referred regardless of
TST result or chest radiograph findings. If the applicant appears very ill and TB is suspected, the
referral should be made immediately so that there is no delay in treatment. At the time of referral,
include in Part 3 of the I-693 form the TST and CXR results, any signs or symptoms, the date of U.S.
arrival, and reason for referral.
Requirements and Recommendations for Referral
to Health Department TB Control Program
Required
referral to HD
*	Chest radiograph suggestive of TB disease (active or inactive)
OR
*	Signs or symptoms of TB, regardless of TST result or chest radiograph
findings
Recommended
referral to HD
for evaluation
for treatment of
latent TB
infection
*	TST >10 mm
OR
*	TST ?5 mm in:
*	an HIV-infected person
*	a recent contact of a TB patient
*	a person with a history of organ transplantation
*	any immunosuppressed person
Table 1. Referral to Health Department TB Control Program by Civil Surgeons
The health department TB Control Program will determine whether the applicant has TB disease and
needs treatment. For applicants requiring referral, the civil surgeon must not classify, issue medical
clearance for TB, or sign the I-693 form until the applicant returns from the local health department
with documentation of the results of his or her TB evaluation.  A diagnosis of infectious pulmonary
TB disease (Class A) will prevent immediate medical clearance for TB.  Applicants diagnosed
with Class A pulmonary TB disease must complete a recommended course of treatment
(minimum of 6 months) before the civil surgeon can medically clear them for TB for the
purposes of USCIS.
Recommended Referral to Local Health Department
CDC and the American Thoracic Society recommend that foreign-born people in the United States who
are recent arrivals ( within 5 years) from high TB prevalence countries,  who have a positive TST
(reaction of 10 mm or greater of induration) and a normal chest radiograph be considered for treatment
of latent TB infection, regardless of age.
Foreign-born persons with TST reactions of only 5 mm who have other risk factors should also be
referred for evaluation for treatment of latent TB. Specifically, when the applicant is HIV-infected, is a
recent contact to a TB case, has a transplanted organ, or has received the equivalent of 15 mg/day or
more of prednisone for at least one month, 5 mm or greater of induration is the TST reaction size at
which the applicant should be evaluated for treatment of latent TB infection. These factors further
increase the risk of developing TB disease.
Some applicants may be at risk for progression of TB infection to TB disease for more than one reason
(e.g., recent arrival from a high TB prevalence country and diabetic; see Appendix C).
The civil surgeon should contact the TB Control Program of the local or state health department in his
or her area to ascertain the local criteria for treatment for latent TB infection and the local health
departments position regarding acceptance of referrals of such applicants from civil surgeons.  Some
health departments with large numbers of TB patients may lack the resources to follow up on all people
with latent infection because they are focusing their efforts on higher-priority active TB cases and their
contacts.  If a health department is not able to accept a referral, the civil surgeon may ask if the health
department is able to provide treatment consultation for an applicant with latent TB infection.  The
health department may also have arrangements with other health-care providers in the community (e.g.,
community-based health centers or managed care organizations) that may be able to provide such
treatment. Once active disease has been excluded, an applicant with latent TB infection can be
medically cleared for TB for the purposes of USCIS, regardless of whether treatment for latent
TB infection has been recommended or completed.
Laboratory Support
All mycobacteriology laboratory work should be performed by the local or state health department or by
a private laboratory that is approved and recommended by the health department. An applicant with an
abnormal chest radiograph(s) suggestive of active TB must provide three sputum specimens on separate
days within a 7-day time frame.  The collection of the three sputa must be supervised. The health
department TB Control Program will determine whether other applicants should submit sputa.
All three sputum specimens must be examined for the presence of acid-fast bacilli (AFB) AND cultured
for M. tuberculosis. Specimens positive for M. tuberculosis complex should be tested for drug susceptibility,
and susceptibility results should be promptly forwarded to the health department.  Drug resistance must
be identified as early as possible in order to ensure appropriate treatment.  Drug susceptibility testing
should be repeated for applicants who do not respond adequately or who have a positive culture despite
2 months of therapy.
VI.	Classification of Applicants with Evidence of TB
The civil surgeon is responsible for medically examining and assigning a TB classification for each
applicant.  Most TB classifications and the actions appropriate to those classifications are self-
explanatory. For example, applicants with abnormal chest radiographs suggestive of active or
inactive TB disease must be referred to the local health department TB Control Program for further
evaluation.  This includes applicants who potentially fall into the Class A- Pulmonary TB Disease,
Active, Infectious category; the Class B1Pulmonary TB, Active, Non-infectious category; and the
Class B2Pulmonary TB, Inactive category.
Please see Section VII for the treatment of applicants with Class A TB disease and Section VIII for
the re-classification of persons with Class A TB disease after treatment.
However, the following three conditions may need more clarification, and these are covered in detail in
the following paragraphs:
*	Class B1Extrapulmonary TB Disease, Active, Non-infectious
*	Class BLatent TB Infection Needing Evaluation for Treatment
*	Class BOther Chest Condition (non-TB)
Class B1 - Extrapulmonary Tuberculosis, Active, Non-infectious
Applicants with Class B1 - Extrapulmonary TB, Active, Non-infectious have:
*	Radiographic or other evidence of extrapulmonary disease.
*	No evidence of pulmonary TB radiographically or clinically.
Initial Actions to be taken by the civil surgeon:
*	Explain to the applicant that he or she may need to complete a full course of drug
therapy (at least 6 months in duration).
*	Assure the applicant that this treatment will not preclude medical clearance for USCIS.
*	Refer the applicant to the health department as a suspected extrapulmonary TB case.
Actions by the civil surgeon after evaluation by health department TB Control Program:
*	When the extrapulmonary TB diagnosis is confirmed in writing through the health
department, check the Class B1 Extrapulmonary TB box on the I-693 form and sign
the Civil Surgeon Certification section (Part 5) of the I-693 form, indicating that the
applicant is free from infectious TB at this time and is medically cleared for TB for the
purposes of USCIS.
*Chest radiograph performed if TST ? 5mm induration. TST performed on all applicants ? 2 years of age.
Figure 1. Process for Classifying TB and Other Chest Conditions. This classification system is designed to assist state and local health department TB Control Programs to
prioritize their efforts to most effectively diagnose and treat applicants with TB conditions.
TB Classifications and Actions
Classification
Criteria
Refer to Health
Dept. (HD) for
Further  Work-
Up
Check
Classif.
Box on
I-693 1
Clear
Applicant
for TB; Sign
 I-693
Re-Classify
After
Treatment
Class APulmonary TB
Disease, Active, Infectious
*	Abnormal chest radiograph(s) suggestive of active TB disease (See Appendix B)
*	Either one or more sputum smears positive for AFB, or one or more cultures
positive for M.tuberculosis complex
Required 2
Yes
No
Yes 3
Class B1Pulmonary TB,
Active, Non-infectious
*	Abnormal chest radiograph(s) suggestive of active TB disease (See Appendix B)
*	Three sputum smears negative for AFB and three cultures negative for M.
tuberculosis complex
Required 2
Yes
Yes
No
Class B1Extrapulmonary
TB, Active, Non-
infectious
*	Radiographic or other evidence of extrapulmonary TB disease
*	No pulmonary TB
Required 4
Yes
Yes
No
Class B2Pulmonary TB,
Inactive
*	Abnormal chest radiograph(s) suggestive of inactive TB disease (See Appendix B)
*	No sputum smears or cultures required5
Required2
Yes
Yes
No
Class BLatent TB
Infection Needing
Evaluation for Treatment
(LTBI)
*	TST reaction ? 10 mm in recent U.S. arrivals (see text)
*	TST reaction ? 5 mm in specific groups (see text)
*	No evidence of active TB disease
*	See text for criteria of other LTBI category
Recommended 6
Yes
Yes
No
Class B Other Chest
Condition (non-TB)
*	Abnormal chest radiograph, not suggestive of  TB disease, needing follow-up (see
Appendix B)
N/A 7
Yes
Yes
No
If the applicant has TB signs or symptoms, he or she should be referred to the health department TB Control Program for further evaluation regardless of TST result or chest
radiograph appearance.
Table 2. TB Classifications and Summary of Appropriate Related Actions. For the first four conditions, classification cannot be determined until evaluation of applicant by
the Health Department TB Control Program has been completed.
1 After evaluation by civil surgeon (and referral to Health Department TB Control Program, if required) is completed. See Appendix D
2 Refer to health department TB Control Program for work-up of suspicious chest radiograph
3 After written confirmation of complete TB treatment on I-693 form, classification is changed in this special circumstance to B2
4 Make required referral to health department TB Control Program for further evaluation and, if needed, initiation of CDC/ATS/IDSA-recommended drug regimen for
extrapulmonary TB
5 If health department TB Control Program decides to perform sputum smears and cultures, categorize as Class A or B1 depending on results
6  After discuss resources with health department TB Control Program
7  See text
Class B - Latent TB Infection Needing Evaluation for Treatment
Applicants with Class B - Latent TB Infection Needing Evaluation for Treatment have:
*	A TST reaction of 10 mm or more of induration, and a history of recent arrival (within
the last 5 years) in the United States from a high-prevalence country
     And
*	No evidence of active TB disease.
     OR
*	A TST reaction of 5 mm or more of induration if the applicant is in one of these
groups:
o	HIV-infected persons
o	Recent contacts of TB cases
o	Patients with transplanted organs
o	Other immunosuppressed patients (receiving the equivalent of 15 mg/day or more
of prednisone for at least one month)
					And
*	No evidence of active TB disease.
     OR
*	A TST reaction of 10 mm or more of induration if the applicant is in one of these
groups:
o	Persons with clinical conditions that place them at high risk (See Appendix C)
o	Injection drug users
o	Residents and employees of high-risk congregate settings (e.g., correctional
facilities, nursing homes, homeless shelters, hospitals, or other health-care facilities)
o	Mycobacteriology laboratory personnel
o	Children <4 years of age, or children and adolescents exposed to adults in high-
risk categories
					And
*	No evidence of active TB disease.
An applicant may fall into more than one risk category for progression of TB infection to TB disease.
(e.g., may be a recent arrival from a country with a high TB prevalence and have a clinical condition
such as diabetes).
Actions to be taken by the civil surgeon:
*	Check the Class B, Latent TB Infection box on the I-693 form.
*	Sign the Civil Surgeon Certification section (Part 5) of the I-693 form, indicating
that the applicant is free of infectious TB at this time.
*	Explain to the applicant that the health department may recommend that he or she
complete a full course of treatment for latent TB infection, but that the applicant is
medically cleared for TB for the purposes of USCIS.
*	It is recommended that the civil surgeon refer the applicant to the local health
department TB Control Program or other health-care provider (depending on previous
agreement with health department) for evaluation for treatment of latent TB infection.
Indicate TST induration, and specific risk factor(s) for progression to TB disease.
Class B - Other Chest Condition (non-TB)
Applicants with Class B - Other Chest Condition (non-TB) have:
An abnormal chest radiograph or a series of chest radiographs suggestive of disease that is not TB
(see Appendix B) in an applicant with no clinical signs or symptoms of active TB.
Actions to be taken by the civil surgeon:
*	Check the Class B, Other Chest Condition (non-TB) box on the I-693 form and
specify condition (e.g. cardiomegaly [enlarged heart], scoliosis in a child) in space
below box.
*	Sign the Civil Surgeon Certification section (Part 5) of the I-693 form, indicating
that the applicant is free of infectious TB at this time, and is medically cleared for TB
for the purposes of USCIS.
*	Advise the applicant about the findings and the type of medical referral needed.
VII.	Treatment of Applicants with Class A TB Disease
If the TB Control Program of the local health department confirms Class A TB (either smear or culture
positive), the health department should treat and manage the TB disease. TB treatment is complex and
effective management requires experience and expertise. Health department TB Control Programs have
access to TB experts and other resources to deal with the potential obstacles associated with curing TB
patients, such as non-adherence to therapy, drug resistance, adverse reactions to medication, and HIV
co-infection. Health departments are ultimately responsible for ensuring that people with TB in the
community are promptly started on and complete appropriate drug regimens, and for conducting
thorough contact investigations.
In all 50 states, the civil surgeon is legally obligated to report all people with suspected or confirmed TB
disease to the local or state health department.  The civil surgeon who wishes to treat an applicant for
TB disease should do so in close collaboration and consultation with the TB Control Program of the
local or state health department. Applicants with suspected TB disease should be started on a treatment
regimen recommended by CDC, the American Thoracic Society (ATS), and the Infectious Diseases
Society of America (IDSA). These recommendations are available on the Internet at URL:
http://www.cdc.gov/mmwr/preview/mmwrhtml/rr5211a1.htm.
VIII.	Re-Classification of Persons with Class A TB after Treatment
An applicant with Class A TB must complete a CDC/ATS/IDSA recommended course of anti-TB
treatment.  The minimum duration of treatment is 6 months.  When treatment has been completed and
the applicant is no longer infectious, a representative of the health department should sign the Referral
Evaluation section (Part 4) of the I-693 form, indicating that the applicant has complied with the
recommended health follow-up.  When the applicant returns to the civil surgeons office, the civil
surgeon should:
*	Cross out the initial Class A diagnosis with a single stroke, and initial and date the
change (civil surgeon should indicate that applicant was initially Class A).
*	Change the applicant's status to Class B2 Pulmonary TB. If TB treatment has been
prolonged, other portions of the medical examination may need to be repeated. When
all portions of the examination are current the civil surgeon can sign the Civil
Surgeon Certification section (Part 5) of the I-693 form, indicating that the applicant
is medically cleared for the purposes of USCIS.
*	Indicate the following information in the Remarks section of the I-693 form (may
attach a separate sheet of paper, if needed):
*	The TB drug regimen used (medication names, dosages, number of doses
given).
*	The date treatment began (month/year).
*	The date treatment was completed (month/year).
*	The date and results of the most recent sputum culture tests (month/year).
IX.	Resources
Civil surgeons can check the CDC/Division of Global Migration and Quarantine (DGMQ) web page at
http://www.cdc.gov/ncidod/dq/civil.htm   for further details and updates on the medical examination
of applicants. If clarification or further guidance is still needed about these Technical Instructions,
contact CDC/DGMQ by fax at (404) 639-4441. Address the fax to Civil Surgeon TB Technical
Instructions.
X.	Appendices
APPENDIX A
PURIFIED PROTEIN DERIVATIVE STORAGE; TST ADMINISTRATION
AND INTERPRETATION
Although activities related to the PPD and TST are often delegated to the civil surgeons staff, the civil
surgeon is ultimately responsible for ensuring that these tasks are performed correctly. Up-to-date, free
instruction is provided in the Mantoux Tuberculin Skin Test Training Materials Kit, which can be
ordered through the Division of Tuberculosis Elimination (DTBE) online ordering system or by mailing
or faxing the DTBE Educational and Training Materials Order Form., available at
https://www2.cdc.gov/nchstp_od/piweb/tborderform.asp, Order Publications link.
Proper Strength of Purified Protein Derivative (PPD) for the TST:
*	The standard strength for each TST is 5 tuberculin units (TU) of PPD.
*	In the U.S., products that utilize 1-TU or 250-TU of PPD should never be used,
because interpretation is based on the use of 5 TU.
How to Correctly Store PPD:
*	Carefully follow the manufacturers instructions for the proper storage and handling of
PPD.
*	Keep PPD vials refrigerated, except while they are being used to fill a syringe.
*	Never pre-fill a syringe.
*	To avoid temperature fluctuations, do not store vials in the refrigerator door.
*	Store PPD in the dark as much as possible; avoid exposure to strong light.
*	Carefully monitor the manufacturers expiration date on each vial of PPD.
*	Record the date that each vial is opened; discard vials that have been open for more
than 30 days.
How to correctly administer the TST:
*	Inject intradermally 0.1 mL of 5 TU PPD tuberculin into inner surface of the forearm.
*	Produce a wheal (discrete, pale elevation of skin) 6 mm to 10 mm in diameter.
*	Do not recap, bend, or break needles, or remove needles from syringes.
*	Follow universal precautions for infection control
How to Correctly Interpret the TST Reaction:
*	A trained health-care worker should read the TST 4872 hours after injection.
*	Measure only induration (palpable, raised, hardened area), not erythema (redness).
*	Measure across the forearm, perpendicular to the long bones.
*	Record reaction in millimeters, even if interpreted as negative. No induration equals 0
mm.
*	A positive reaction can be measured up to one week after testing. If a negative reaction
is not read within 72 hours, the test must be repeated.
*	Patients should never read their own TST results.
How to Record the Administration and Results of the TST:
       Document in writing:
*	Date and time of administration.
*	Arm that is tested (right or left).
*	Brand name, lot number, and expiration date of PPD.
*	Name of person administering the test.
*	Date and time of reading.
*	Exact millimeters of induration.  (If there is no induration, 0 mm should be
recorded). Never use the terms positive or negative in recording the TST results.
*	Name of person reading the test.
APPENDIX B
RADIOGRAPHIC FINDINGS SUGGESTIVE OF TB OR OTHER DISEASE
Chest Radiographic Findings Suggestive of TB disease:
Chest Radiographic Findings that Can Suggest ACTIVE TB disease:
This category comprises all findings typically associated with active pulmonary TB.  An applicant
with any of the following findings must be referred to the TB Control Program of the health
department and submit specimens for smear and culture.
1.	Infiltrate or consolidationOpacification of airspaces within the lung parenchyma.  Infiltrate  or
consolidation can be dense or patchy and may have irregular, ill-defined, or hazy borders.
2.	Any cavitary lesionLucency (darkened area) within the lung parenchyma, with or without
irregular margins that may be surrounded by air-space consolidation, or by nodular or reticular
opacities, or both. The walls surrounding the lucent area can be thick or thin.  Calcification can
exist around a cavity.
3.	Nodule with poorly defined marginsRound opacity within the lung parenchyma, consistent
with a tuberculoma.  Nodules included in this category are those with margins that are indistinct
or poorly defined. The surrounding haziness can be either subtle or readily apparent, suggesting
coexisting air-space consolidation.
4.	Pleural effusionPresence of a significant amount of fluid within the pleural space. This finding
must be distinguished from blunting of the costophrenic angle, which may or may not represent
a small amount of fluid within the pleural space (except in children,  for whom even minor
blunting must be considered a finding that can suggest active TB).
5.	Hilar or mediastinal lymphadenopathyEnlargement of lymph nodes in one or both hila and/or
within the mediastinum, with or without associated atelectasis (volume loss) or consolidation.
6.	OtherAny other finding suggestive of active TB, such as miliary TB. Miliary TB demonstrates
nodules that are uniform in size, measuring 1 to 2 mm (millet size), distributed throughout the
parenchyma.
Chest Radiographic Findings that Can Suggest INACTIVE TB disease:
This category includes findings that are suggestive of prior TB disease that is inactive. Assessments of
the activity of TB disease cannot be made accurately on the basis of a single radiograph. An
applicant with any of the following findings must be referred to the health department TB Control
Program to determine if further evaluation (including specimens for smear and culture) is needed. If
sputum smears and cultures are performed, the laboratory results will determine whether Class A or B1
is assigned. If no smears or cultures are performed, Class B2 should be assigned.
1.	Discrete fibrotic scar or linear opacityDiscrete linear or reticular opacity within the lung. The
edges of the opacity should be distinct, and there should be no suggestion of airspace
opacification or haziness between or surrounding the linear or reticular lesion. Calcification can
be present within the lesion.
2.	Discrete nodule(s) without calcificationOne or more nodular opacities with distinct borders
and no surrounding airspace consolidation. Nodules are generally round or have rounded edges,
features that distinguish them from airspace consolidation. To be included here, these nodules
must be non-calcified. A solitary calcified nodule is included in the category Other Chest
Radiographic Findings, no follow-up needed based solely on radiographic findings.
3.	Discrete fibrotic scar with volume loss or retractionDiscrete linear opacities with reduction in
the space occupied by the upper lobe. Associated signs include upward deviation of the fissure
or hilum on the corresponding side, plus/minus asymmetry of the volumes of the two thoracic
cavities.
4.	OtherAny other finding suggestive of prior TB, such as upper lobe bronchiectasis.
Bronchiectasis is bronchial dilation with bronchial wall thickening.
OTHER Chest Radiographic Findings:
Follow-up needed:
This category includes findings that indicate the need for follow-up evaluation of a  non-TB condition.
1.	Musculoskeletal abnormalitiesNew fractures or other bony abnormalities, such as scoliosis
in a child.
2.	Cardiac abnormalitiesCardiac enlargement, cardiac anomalies, or vascular abnormalities of
significant nature.
3.	Other Any other finding that the panel physician believes needs follow-up.
No follow-up needed based solely on radiographic findings:
This category includes findings that are minor and not specifically suggestive of TB disease. However,
referral to the TB Control Program of the local health department for applicants with these radiographic
findings may be required or recommended based on TB signs or symptoms or TST result.
1.	Pleural thickeningIrregularity or abnormal prominence of the pleural margin, including apical
capping (thickening of the pleura in the apical region). Pleural thickening can be calcified.
2.	Diaphragmatic tentingA localized accentuation of the normal convexity of the
hemidiaphragm as if pulled upwards by a string.
3.	Blunting of costophrenic angle (in adults)Loss of sharpness of one or both costophrenic
angles. Blunting can be related to a small amount of fluid in the pleural space or to pleural
thickening and, by itself, is a nonspecific finding. In contrast, a larger pleural effusion suggests
active TB disease. Note: In children, even minor blunting of the costophrenic angle
suggests active TB disease.
4.	Solitary calcified nodule or lymph nodeDiscrete calcified nodule (granuloma) within the lung,
or calcified lymph node. The calcified lymph node can be within the hilum or mediastinum. The
borders must be sharp, distinct, and well defined. This finding was considered to be Class
B3 TB in the previous TIs, but is no longer.
APPENDIX C
REFERENCE CHARTS
Risk Factors for Progression of TB Infection to TB Disease
TB-Specific
Previous TB (in a person who received inadequate or no treatment) indicated by chest radiograph findings
Recent infection with M. tuberculosis (within the past 2 years), particularly in infants and children
Other Clinical Conditions
Cancer of the head and neck
Chronic malabsorption syndromes
Diabetes mellitus
End-stage renal disease
Hematologic and reticulendothelial diseases (e.g., leukemia and Hodgkins disease)
HIV infection
Illicit drug use or use of other groups of high-risk substances
Intestinal bypass or gastrectomy
Low body weight (10% or more below ideal)
Prolonged corticosteroid therapy or other immunosuppressive therapy
Silicosis
Pediatric TB Signs and  Symptoms
These  are more commonly found in children
Dyspnea (difficulty breathing)
Failure to thrive
Growth delay
Hepatomegaly (enlarged liver)
Lethargy
Lymphadenopathy (cervical, axillary)
Malnutrition
Meningeal Signs
Pallor
Site-specific signs or symptoms of the  middle ear and
mastoid, bones, or joints
Splenomegaly (enlarged spleen)
Tachycardia (rapid heart rate)
Tachypnea (rapid respiratory rate)
Wheezing
TB Signs and Symptoms
Chills
Chest pain
Easy fatigability
Fever
Hemoptysis (blood in sputum)
Loss of appetite
Night sweats
Productive, prolonged cough
Weight loss
TB Classifications
Class A  Pulmonary TB, Active, Infectious
Class B1 - Pulmonary TB, Active, Non-infectious
Class B1  Extrapulmonary TB, Active, Non-infectious
Class B2  Pulmonary TB, Inactive
Class B  Latent TB Infection Needing Evaluation for Treatment
Class B - Other Chest Condition (non-TB)
APPENDIX D
FORM I-693  (SAMPLE--NOT FOR USE)
								OMB No. 1615-0033; Expires 08/31/09
Department of Homeland Security                     			I-693, Report of Medical
U.S. Citizenship and Immigration Services				Examination and Vaccination Record
____________________________________________________________________________________________
START HERE  Please type or print in CAPITAL letters (Use black ink)
Part 1. Information about you (The person requesting a medical examination or vaccinations must complete this
part)
Family Name (Last Name)	                Given Name (First Name)             Full Middle Name
Home Address: Street Number and Name			               Apt. Number   Gender:
 									          0 Male  0 Female
City				State	  Zip Code	  Phone Number (Include Area Code)    Date of Birth
Place of Birth (City/Town/Village)    Country of Birth	           A-Number (if any)      U.S. Social Security # (if any)
____________________________________________________________________________________________
Applicant's Certification
I certify under penalty of perjury under United States law that I am the person who is identified in Part 1 of this
Form I-693, Report of Medical Examination and Vaccination Record, and that the information in Part 1 of this form
is true to the best of my knowledge. I understand the purpose of this medical exam, and I authorize the required tests
and procedures to be completed. If it is determined that I willfully misrepresented a material fact or provided
false/altered information or documents with regard to my medical exam, I understand that any immigration benefit I
derived from this medical exam may be revoked, that I may be removed from the United States, and that I may be
subject to civil or criminal penalties.
Signature - Do not sign or date this form until instructed to do so
by the civil surgeon	 							Date (mm/dd/yyyy)
Part 2.  Medical examination  (The civil surgeon completes this part)
1. Examination
  Date of First Examination 		Date(s) of Follow-up Examination(s) if Required:
				Date of Exam	         Date of Exam		Date of Exam
Summary of Overall Findings:
0 No Class A or Class B Condition  0 Class A Conditions (see 2 through 5 below)  0 Class B Conditions (see 2
										through 6 below)
2. Communicable Diseases of Public Health Significance
  A.  Tuberculosis (TB)
    0 Tuberculin Skin Test (TST) (Required for applicants 2 years of age and older: for children under 2 years of
age, see pp. 11-12 of Technical Instructions at http://www.cdc.gov/ncidod/dq/civil.htm.)
          Date TST Applied		Date TST Read		Size of Reaction (mm)
    0 Chest X-Ray - Required ONLY for TST reactions of > 5mm or if specific TST exception criteria met, or for
an applicant with TB symptoms or immunosuppression (e.g., HIV). Attach copy of X-Ray Report.
          Date Chest X-Ray Taken		Date Chest X-Ray Read	Results
Findings:
0No Class A or Class B TB       0Class B1 Pulmonary TB       0Class B2 Pulmonary TB       0Class B, Other
										Chest Condition (non-TB)
0 Class A Pulmonary TB	 Disease 0 Class B1 Extra Pulmonary TB	0 Class B, Latent TB Infection
Remarks: (Include any signs or symptoms of TB, additional tests, and therapy given, with stop and start dates and
any changes.)
Part 2.  Medical examination (Continued)
B.   Syphilis
0 Serologic Test for Syphilis (Required for applicants 15 years and older)
       0 Screening Nonreactive
      Date Screening Run							0 Screening Reactive, Titer 1:
    If Reactive, Date Confirmation Run					0 Confirmation Nonreactive
									0 Confirmation Reactive
Findings:
0 No Class A or Class B Syphilis           0 Syphilis, Class A (untreated)           0 Syphilis, Class B
(with residual deficit, treated in the
past year)
Remarks: (Include any therapy given with doses and dates.)
____________________________________________________________________________________________
C.  HIV/AIDS
0 Serologic Test for HIV antibody (Required for applicants 15 years and older)
      Date Screening Run	0 Screening Negative	   If Positive or Indeterminate,       0 Confirmation Negative
			0 Screening Positive	   Date Confirmation Run	            0 Confirmation Positive
			0 Screening Indeterminate
Findings:
0 No Class A HIV		0 HIV, Class A
Remarks: (Include any signs or symptoms of HIV infection, therapy given, and any counseling, or referrals.)
Part 2.  Medical examination (Continued)
D.  Other Class A/Class B Conditions for Communicable Diseases of Public Health Significance
Findings:
0 Chancroid, Class A     			              0 Gonorrhea, Class A
0 Granuloma Inguinale,Class A		              0 Lymphogranuloma Venereum, Class A
0 Hansens Disease (Leprosy, Infectious), Class A   0 Hansens Disease (Leprosy, Noninfectious), Class B
Remarks: (Include any therapy given and any counseling, or referrals.)
3. Physical or Mental Disorders With Associated Harmful Behavior
0 Physical/Mental Disorder, With Associated Harmful Behavior, Class A
0 Physical/Mental Disorder, Without Associated Harmful Behavior, Class B
Remarks: (Include diagnosis, with likelihood of harmful behavior to recur, therapy given, and any counseling, or
referrals.)
____________________________________________________________________________________________
4. Drug Abuse/Drug Addiction
0 Substance (Drug) Use, Listed in Section 202 of Controlled Substance Act, Class A
0 Substance (Drug) Use, Not Listed in Section 202 of Controlled Substance Act, But With Associated Harmful
Behavior, Class A
0 Prior Substance (Drug) Use in Remission, Class B
Remarks: (Include any therapy given, rehabilitation, counseling, or referrals.)
Part 2.  Medical examination (Continued)
5. Vaccinations (See Technical Instructions at http://www.cdc.gov/ncidod/dq/civil.htm for list of required vaccines.)
Vaccine History Transferred From a Written
Record
Vaccine
Given
Completed Series
Waiver(s) to Be Requested from USCIS
Vaccine
Date
Recei-
ved
mm/dd
/yyyy
Date
Recei-
ved
mm/dd
/yyyy
Date
Recei-
ved
mm/dd
/yyyy
Date
Given
by Civil
Surgeon
mm/dd/
yyyy
Mark an X if
completed; write
date of lab test if
immune or VH if
varicella history
Blanket
Not Medically Appropriate
Not Age
Appro-
priate
Contra-
indication
Insuffic-
ient
Time
Interval
Not
Flu Season
Specify Vaccine:
DT     0
DTP   0
DTap  0
Specify vaccine:
Td      0
Tdap  0
Specify vaccine:
OPV   0
IPV     0
MMR (Measles-
Mumps-
Rubella) or if
monovalent or
other
combination of
the vaccines are
given, specify
vaccine(s):
Hib
Hepatitis B
Varicella
Pneumococcal
Influenza
Other vaccine
(specify below):
Continued: Vaccine History Transferred
From a Written Record
Vaccine
Given
Completed Series
Waiver(s) to Be Requested from USCIS
Vaccine
Date
Recei-
ved
mm/dd
/yyyy
Date
Recei-
ved
mm/dd
/yyyy
Date
Recei-
ved
mm/dd
/yyyy
Date
Given
by Civil
Surgeon
mm/dd/
yyyy
Mark an X if
completed; write
date of lab test if
immune or VH if
varicella history
Blanket
Not Medically Appropriate
Not Age
Appro-
priate
Contra-
indication
Insuffic-
ient
Time
Interval
Not
Flu Season
Other vaccine
(specify below):
Other vaccine
(specify below):
Other vaccine
(specify below):
Other vaccine
(specify below):
					Give Copy to Applicant
Results:  0 Applicant may be eligible for blanket waiver(s) as indicated above.
	 0 Applicant will request an individual waiver based on religious or moral convictions.
	 0 Vaccine history complete for each vaccine, all requirements met.
	 0 Applicant does not meet immunization requirements.
A-number (if any)                   	   Name (Type or print your name)
____________________________________________________________________________________________
6.   List other medical conditions, Class B Other (e.g. hypertension, diabetes)
Part 3. Referral to health department or other doctor/facility (To be completed by Civil Surgeon, if referral was
made)
Type or Print Name of Doctor or Health Department     		      Date of Referral (mm/dd/yyyy)
Address: (Street Number and Name, City, State and Zip Code)		Daytime Phone Number (Include
Area Code)
Remarks: (Include name of medical condition and reasons for referral.)
Part 4. To Be Completed by Physician or Health Department Performing Referral Evaluation
The applicant identified on this form was referred to me by the civil surgeon named in Part 5 of this form.  I have
provided appropriate evaluation/treatment.
Type or Print Full Name of Evaluating Physician or Health Department	  Signature
Address: (Street Number and Name, City, State and Zip Code)		          	Date (mm/dd/yyyy)
Name of Medical Practice or Health Department			              	Daytime Phone Number (Include
Area Code)
Remarks: (Attach a separate piece of paper, if needed.)
Part 5.  Civil Surgeon's Certification (Do not sign form or have the applicant sign in Part 1 until all health
follow-up requirements have been met.)
I certify under penalty of perjury under United States law that: I am a civil surgeon in current status designated to
examine applicants seeking certain immigration benefits in the United States; I have a currently valid and
unrestricted license to practice medicine in the state where I am performing medical examinations; I performed this
examination of the person identified in Part 1of this Form I-693, after having made every reasonable effort to verify
that person whom I examined is the person identified in Part 1; that I performed the examination in accordance with
the Centers for Disease Control and Prevention's Technical Instructions, and all supplemental information or updates
provided to me; and that all information provided by me on this form is true and correct to the best of my
information, knowledge, and belief.
Type or Print Full Name    (First, Middle, Last)                    		Signature
Address (Street Number and Name, City, State and Zip Code)				          Date (mm/dd/yyyy)
Name of Medical Practice or Health Department			    Daytime Phone No. (Include Area Code)
Civil Surgeon ID # 						    E-Mail Address
Part 6.  Health department identifying information. (If completed by State or local health department on behalf
of a refugee, place a stamp or seal where indicated.)
Type or Print Name							(Place State or local health
		                                                                                                      Department stamp/seal below.)
Signature
Date (mm/dd/yyyy)		Daytime Phone Number (Include Area Code)
  Diabetes mellitus; silicosis; prolonged corticosteroid therapy and other immunosuppressive therapy; cancer of the head
and neck; hematologic and reticuloendothelial diseases; end-stage renal disease; intestinal bypass or gastrectomy; chronic
malabsorption syndromes; or low body weight.
Technical Instructions for Civil Surgeons
Tuberculosis Medical Examination   17
Technical Instructions for Civil Surgeons
Tuberculosis Medical Examination   19
Technical Instructions for Civil Surgeons
Tuberculosis Medical Examination   25
Technical Instructions for Civil Surgeons
Tuberculosis Medical Examination   38