BLASTP 2.0.8 [Jan-05-1999]

Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= YER023W PRO3, Chr V from 201075-201935
         (286 letters)

Database: nr
           361,503 sequences; 110,384,460 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

gi|417541|sp|P32263|PROC_YEAST PYRROLINE-5-CARBOXYLATE REDUCTAS...   534  e-151
gi|3024443|sp|Q12740|PROC_ZALAR PYRROLINE-5-CARBOXYLATE REDUCTA...   161  7e-39
gi|3024438|sp|P74572|PROC_SYNY3 PYRROLINE-5-CARBOXYLATE REDUCTA...   133  1e-30
gi|1709786|sp|P54904|PROC_ARATH PYRROLINE-5-CARBOXYLATE REDUCTA...   130  1e-29
gi|417540|sp|Q04708|PROC_PEA PYRROLINE-5-CARBOXYLATE REDUCTASE ...   126  2e-28
gi|1172629|sp|P46540|PROC_CORGL PYRROLINE-5-CARBOXYLATE REDUCTA...   125  2e-28
gi|3688282|emb|CAA09332| (AJ010739) pyrroline-5-carboxylate red...   123  1e-27
gi|130972|sp|P17817|PROC_SOYBN PYRROLINE-5-CARBOXYLATE REDUCTAS...   122  2e-27
gi|3024430|sp|O04016|PROC_ACTCH PYRROLINE-5-CARBOXYLATE REDUCTA...   119  2e-26
gi|886762 (U27806) pyrroline carboxylate reductase [Plasmodium ...   115  5e-25
gi|3832514 (AF098020) pyrroline 5-carboxylate reductase [Drosop...   111  4e-24
gi|3024442|sp|Q12641|PROC_NEUCR PYRROLINE-5-CARBOXYLATE REDUCTA...   108  6e-23
gi|1709791|sp|P54552|PROI_BACSU PYRROLINE-5-CARBOXYLATE REDUCTA...   106  2e-22
gi|130969|sp|P00373|PROC_ECOLI PYRROLINE-5-CARBOXYLATE REDUCTAS...   106  2e-22
gi|3878731|emb|CAA91943| (Z67995) similar to pyrroline-5-carbox...   105  3e-22
gi|417539|sp|P32322|PROC_HUMAN PYRROLINE-5-CARBOXYLATE REDUCTAS...   102  2e-21
gi|3041718|sp|P14383|PROH_BACSU PYRROLINE-5-CARBOXYLATE REDUCTA...   102  4e-21
gi|2982885 (AE000676) pyrroline carboxylate reductase [Aquifex ...   102  4e-21
gi|143480 (M24523) ORF 257 proC protein (put.); putative [Bacil...    94  8e-19
gi|1172630|sp|P43869|PROC_HAEIN PYRROLINE-5-CARBOXYLATE REDUCTA...    84  1e-15
gi|1172631|sp|P46725|PROC_MYCLE PYRROLINE-5-CARBOXYLATE REDUCTA...    82  3e-15
gi|130971|sp|P22008|PROC_PSEAE PYRROLINE-5-CARBOXYLATE REDUCTAS...    81  8e-15
gi|1709789|sp|P52053|PROC_VIBAL PYRROLINE-5-CARBOXYLATE REDUCTA...    77  1e-13
gi|1709787|sp|Q11141|PROC_MYCTU PYRROLINE-5-CARBOXYLATE REDUCTA...    77  1e-13
gi|4033772|sp|P27771|PROC_TREPA PYRROLINE-5-CARBOXYLATE REDUCTA...    76  2e-13
gi|3024445|sp|Q20848|PROC_CAEEL PUTATIVE PYRROLINE-5-CARBOXYLAT...    70  2e-11
gi|1709788|sp|P54893|PROC_THETH PYRROLINE-5-CARBOXYLATE REDUCTA...    69  3e-11
gi|98368|pir||B32807 hypothetical protein 199 - Bacillus subtil...    67  1e-10
gi|4155682 (AE001536) putative PYRROLINE-5-CARBOXYLATE REDUCTAS...    63  2e-09
gi|281467|pir||S27734 pyrroline-5-carboxylate reductase - Trepo...    63  2e-09
gi|3024435|sp|O25773|PROC_HELPY PYRROLINE-5-CARBOXYLATE REDUCTA...    59  5e-08
gi|2632012|emb|CAA05571| (AJ002571) YkeA [Bacillus subtilis] >g...    53  3e-06
gi|628998|pir||S39862 comE Reverse-ORF - Bacillus subtilis >gi|...    52  4e-06
gi|1705939|sp|P39696|CME4_BACSU COME OPERON PROTEIN 4                 52  4e-06
gi|1303795|gnl|PID|d1013130 (D84432) ComED [Bacillus subtilis] ...    51  8e-06
gi|2621992 (AE000865) pyrroline-5-carboxylate reductase [Methan...    51  1e-05
gi|2209378 (AF006720) ProH [Bacillus subtilis]                        49  4e-05

>gi|417541|sp|P32263|PROC_YEAST PYRROLINE-5-CARBOXYLATE REDUCTASE
           (P5CR) (P5C REDUCTASE) >gi|101465|pir||S25293
           pyrroline-5-carboxylate reductase (EC 1.5.1.2) - yeast
           (Saccharomyces cerevisiae) >gi|172243 (M57886)
           pyrroline-5-carboxylate reductase [Saccharomyces
           cerevisiae] >gi|432970|emb|CAA40614| (X57338)
           deltal-pyrroline-5-carboxylate  reductase [Saccharomyces
           cerevisiae] >gi|603615 (U18778) Pro3p: delta
           1-pyrroline-5-carboxylate reductase [Saccharomyces
           cerevisiae]
           Length = 286
           
 Score =  534 bits (1360), Expect = e-151
 Identities = 271/286 (94%), Positives = 271/286 (94%)

Query: 1   MTYTLAILGCGVMGQALLSAIYNAPKAADETAAAFYPSKIITCNHDEPSAQQVTDLVETF 60
           MTYTLAILGCGVMGQALLSAIYNAPKAADETAAAFYPSKIITCNHDEPSAQQVTDLVETF
Sbjct: 1   MTYTLAILGCGVMGQALLSAIYNAPKAADETAAAFYPSKIITCNHDEPSAQQVTDLVETF 60

Query: 61  DESPNGIKVESTYGHNVSAVEEASVVLLGTKPFLAEEVLNGVKSVIGGKLLISLAAGWTI 120
           DESPNGIKVESTYGHNVSAVEEASVVLLGTKPFLAEEVLNGVKSVIGGKLLISLAAGWTI
Sbjct: 61  DESPNGIKVESTYGHNVSAVEEASVVLLGTKPFLAEEVLNGVKSVIGGKLLISLAAGWTI 120

Query: 121 DQLSQYTSTVCRVMTNTPAKYGYGCAVVSYSADVSKEQKPLVNELISQVGKYVELPEKNM 180
           DQLSQYTSTVCRVMTNTPAKYGYGCAVVSYSADVSKEQKPLVNELISQVGKYVELPEKNM
Sbjct: 121 DQLSQYTSTVCRVMTNTPAKYGYGCAVVSYSADVSKEQKPLVNELISQVGKYVELPEKNM 180

Query: 181 DAATALVGSGPAFVXXXXXXXXXXXXXXXIPLQESKECAMKVLEGTVKMVEKSGAHPSVL 240
           DAATALVGSGPAFV               IPLQESKECAMKVLEGTVKMVEKSGAHPSVL
Sbjct: 181 DAATALVGSGPAFVLLMLESLMESGLKLGIPLQESKECAMKVLEGTVKMVEKSGAHPSVL 240

Query: 241 KHQVCTPGGTTIAGLCVMEEKGVKSGIINGVEEAARVASQLGQKKK 286
           KHQVCTPGGTTIAGLCVMEEKGVKSGIINGVEEAARVASQLGQKKK
Sbjct: 241 KHQVCTPGGTTIAGLCVMEEKGVKSGIINGVEEAARVASQLGQKKK 286

>gi|3024443|sp|Q12740|PROC_ZALAR PYRROLINE-5-CARBOXYLATE REDUCTASE
           (P5CR) (P5C REDUCTASE) >gi|2144258|pir||JC4830
           pyrroline-5-carboxylate reductase (EC 1.5.1.2) -
           Zalerion arboricola >gi|1377901 (U33266) pyrroline
           carboxylate reductase [Zalerion arboricola]
           Length = 320
           
 Score =  161 bits (402), Expect = 7e-39
 Identities = 110/306 (35%), Positives = 156/306 (50%), Gaps = 33/306 (10%)

Query: 4   TLAILGCGVMGQALLSAIY------NAPKA----ADETAAAFYPSKIITCNHDEPSAQQV 53
           TLA++GCG MG A+LS I       +AP +     DET +   P+K I C      A+++
Sbjct: 12  TLAVIGCGTMGIAILSGILASLDEIHAPNSQSSETDETPSKL-PTKFIACVRSPKGAEKI 70

Query: 54  TDLVETFDESPNGIKVESTYGHNVSAVEEASVVLLGTKPFLAEEVLN--GVKSVIGGKLL 111
              +     SP    V+     NV+A  EA VVLLG KP++AE +L   G+   + GKLL
Sbjct: 71  KKAL-----SPYKTPVKIIQSDNVTACREADVVLLGCKPYMAEGILGEEGMVDALKGKLL 125

Query: 112 ISLAAGWTIDQLSQYT-------------STVCRVMTNTPAKYGYGCAVVSYSAD-VSKE 157
           IS+ AG   +Q+  Y                V R M NT +       V++ S+  +S  
Sbjct: 126 ISILAGVPAEQIYGYMYGKTPVNPEKEGLCQVVRAMPNTASGIRESMTVIATSSPPLSAT 185

Query: 158 QKPLVNELISQVGKYVELPEKNMDAATALVGSGPAFVXXXXXXXXXXXXXXXIPLQESKE 217
              L+  +  ++G  V+LP   MDA+TAL GSGPAF                +P  E++ 
Sbjct: 186 TSSLITWIFKRIGDVVQLPAATMDASTALCGSGPAFFALILEAAIDGAVAMGLPRAEAQR 245

Query: 218 CAMKVLEGTVKMVEKSGAHPSVLKHQVCTPGGTTIAGLCVMEEKGVKSGIINGVEEAARV 277
            A + ++G   +V  SG HP++LK +V TPGG TI GL V+EE GV+  +   V EA  V
Sbjct: 246 MAAQTMKGAAGLV-LSGEHPALLKDKVTTPGGCTIGGLMVLEEGGVRGTVARAVREATVV 304

Query: 278 ASQLGQ 283
           ASQLG+
Sbjct: 305 ASQLGK 310

>gi|3024438|sp|P74572|PROC_SYNY3 PYRROLINE-5-CARBOXYLATE REDUCTASE
           (P5CR) (P5C REDUCTASE) >gi|1653768|gnl|PID|d1019412
           (D90916) pyrroline carboxylate reductase [Synechocystis
           sp.]
           Length = 267
           
 Score =  133 bits (332), Expect = 1e-30
 Identities = 89/286 (31%), Positives = 148/286 (51%), Gaps = 21/286 (7%)

Query: 1   MTYTLAILGCGVMGQALLSAIYNAPKAADETAAAFYPSKIITCNHDEPSAQQVTDLVETF 60
           M+  L I+G GVM +A+L+ +      A++T A   P +II     EP   +   L +T+
Sbjct: 1   MSIQLGIIGGGVMAEAILARLI-----AEKTYA---PEEIIV---GEPHGARRDYLQKTY 49

Query: 61  DESPNGIKVESTYGHNVSAVEEASVVLLGTKPFLAEEVLNGVKSVIGGKLLISLAAGWTI 120
                 ++V      N  A   + V+LL  KP + + VL  +       L+IS+ AG ++
Sbjct: 50  Q-----VRVSPD---NQEAANVSEVLLLAVKPQVLDRVLASLAGGANRPLVISILAGVSL 101

Query: 121 DQLSQY--TSTVCRVMTNTPAKYGYGCAVVSYSADVSKEQKPLVNELISQVGKYVELPEK 178
            ++ +      + R M NTPA  G G   ++ +  V  +Q      + S VG  VE+PE 
Sbjct: 102 QRIQKGFPDHAIIRAMPNTPATVGAGMTAIAANKMVEPDQLAKAKAIFSAVGNVVEVPEN 161

Query: 179 NMDAATALVGSGPAFVXXXXXXXXXXXXXXXIPLQESKECAMKVLEGTVKMVEKSGAHPS 238
            MDA T + GSGPA+V               +P   +++ A++ + GT ++++++  HP+
Sbjct: 162 LMDAVTGVSGSGPAYVALMIEALADGGVLAGLPRAIAQKLALQTVLGTAELIKETEEHPA 221

Query: 239 VLKHQVCTPGGTTIAGLCVMEEKGVKSGIINGVEEAARVASQLGQK 284
            +K +V +PGGTTIAG+ V+E+ G +S II  V  A R + +LG+K
Sbjct: 222 QIKDKVTSPGGTTIAGVAVLEKMGFRSAIIEAVRAAYRRSQELGKK 267

>gi|1709786|sp|P54904|PROC_ARATH PYRROLINE-5-CARBOXYLATE REDUCTASE
           (P5CR) (P5C REDUCTASE) >gi|541894|pir||JQ2334
           pyrroline-5-carboxylate reductase (EC 1.5.1.2) -
           Arabidopsis thaliana >gi|166815 (M76538) pyrroline
           carboxylate reductase [Arabidopsis thaliana]
           >gi|1632776|emb|CAA70148| (Y08951) T5r protein
           [Arabidopsis thaliana]
           Length = 276
           
 Score =  130 bits (324), Expect = 1e-29
 Identities = 84/285 (29%), Positives = 144/285 (50%), Gaps = 22/285 (7%)

Query: 2   TYTLAILGCGVMGQALLSAIYNAPKAADETAAAFYPSKIITCNHDEPSAQQVTDLVETFD 61
           ++ +  +G G M +++   +          +    P++I T  H   + +   D+ E+F 
Sbjct: 10  SFKVGFIGAGKMAESIARGVV--------ASGVLPPNRICTAVHSNLNRR---DVFESF- 57

Query: 62  ESPNGIKVESTYGHNVSAVEEASVVLLGTKPFLAEEVLNGVKSVIG-GKLLISLAAGWTI 120
               G+ V ST   +   V+E+ VV+   KP + ++ +  +KS +   K+L+S+AAG  +
Sbjct: 58  ----GVNVFST---SEEVVKESDVVIFSVKPQVVKKAVTELKSKLSKNKILVSVAAGIKL 110

Query: 121 DQLSQYTST--VCRVMTNTPAKYGYGCAVVSYSADVSKEQKPLVNELISQVGKYVELPEK 178
           + L +++      RVM NTPA  G   +V+S     ++E   +V  L   VGK ++  EK
Sbjct: 111 NDLQEWSGQDRFIRVMPNTPAAVGEAASVMSLGTGATEEDGAIVAMLFGAVGKILKADEK 170

Query: 179 NMDAATALVGSGPAFVXXXXXXXXXXXXXXXIPLQESKECAMKVLEGTVKMVEKSGAHPS 238
             DA T L GSGPA++               +P + +   A + + G   MV K+G HP 
Sbjct: 171 MFDAVTGLSGSGPAYIFLAIEALADGGVAAGLPRELALSLASQTVLGAATMVSKTGKHPG 230

Query: 239 VLKHQVCTPGGTTIAGLCVMEEKGVKSGIINGVEEAARVASQLGQ 283
           VLK  V +PGGTTIAG+  +E+   ++ ++N V  AA+ + +L Q
Sbjct: 231 VLKDDVTSPGGTTIAGVHELEKGSFRATLMNAVVAAAKRSRELSQ 275

>gi|417540|sp|Q04708|PROC_PEA PYRROLINE-5-CARBOXYLATE REDUCTASE
           (P5CR) (P5C REDUCTASE) >gi|20851|emb|CAA44646| (X62842)
           pyrroline carboxylate reductase [Pisum sativum]
           >gi|445614|prf||1909360A pyrroline carboxylate reductase
           [Pisum sativum]
           Length = 273
           
 Score =  126 bits (313), Expect = 2e-28
 Identities = 85/283 (30%), Positives = 136/283 (48%), Gaps = 23/283 (8%)

Query: 2   TYTLAILGCGVMGQALLSAIYNAPKAADETAAAFYPSKIITCNHDEPSAQQVTDLVETFD 61
           +YTL  +G G M +++         A   + +   PS  I   H  PS +   + +    
Sbjct: 10  SYTLGFIGAGKMAESI---------AKGASRSGVLPSSRIVTAHSNPSRRAAFESI---- 56

Query: 62  ESPNGIKVESTYGHNVSAVEEASVVLLGTKPFLAEEVLNGVKSVIG-GKLLISLAAGWTI 120
               GI V S+   N   V  ++VV+   KP L ++V+  +K ++   KLL+S+AAG  +
Sbjct: 57  ----GITVLSS---NDDVVRASNVVVFSVKPQLVKDVVLKLKPLLTKDKLLVSVAAGIKL 109

Query: 121 DQLSQYTS--TVCRVMTNTPAKYGYGCAVVSYSADVSKEQKPLVNELISQVGKYVELPEK 178
             L ++       RVM NTPA  G   +V+S     ++E   L+++L   +GK  +  +K
Sbjct: 110 KDLQEWAGHERFIRVMPNTPAAVGQAASVMSLGGAATEEDANLISQLFGSIGKIWKADDK 169

Query: 179 NMDAATALVGSGPAFVXXXXXXXXXXXXXXXIPLQESKECAMKVLEGTVKMVEKSGAHPS 238
             DA T L GSGPA++               +P   +   A + + G   M   SG HP 
Sbjct: 170 FFDAITGLSGSGPAYIYLAIEALADGGVAAGLPRDLALSLASQTVLGAASMATLSGKHPG 229

Query: 239 VLKHQVCTPGGTTIAGLCVMEEKGVKSGIINGVEEAARVASQL 281
            LK  V +PGGTTIAG+  +E+ G +  ++N V  AA+ + +L
Sbjct: 230 QLKDDVTSPGGTTIAGVHELEKGGFRGTLMNAVVAAAKRSREL 272

>gi|1172629|sp|P46540|PROC_CORGL PYRROLINE-5-CARBOXYLATE REDUCTASE
           (P5CR) (P5C REDUCTASE) >gi|950193 (U31225)
           L-proline:NADP+ 5-oxidoreductase [Corynebacterium
           glutamicum]
           Length = 270
           
 Score =  125 bits (312), Expect = 2e-28
 Identities = 84/287 (29%), Positives = 136/287 (47%), Gaps = 27/287 (9%)

Query: 4   TLAILGCGVMGQALLSAIYNAPKAADETAAAFYPSKIITCNHDEPSAQQVTDLVETFDES 63
           T+A++G G +G+AL+S +          AA   P  I   N  E   Q++ D     + +
Sbjct: 3   TIAVIGGGQIGEALVSGLI---------AANMNPQNIRVTNRSEERGQELRDRYGILNMT 53

Query: 64  PNGIKVESTYGHNVSAVEEASVVLLGTKPFLAEEVLNGVKSVIGGK----LLISLAAGWT 119
            N             A +EA VV L  KP    EVL+ +   +       +++S+AAG +
Sbjct: 54  DNS-----------QAADEADVVFLCVKPKFIVEVLSEITGTLDNNSAQSVVVSMAAGIS 102

Query: 120 IDQLSQYTST---VCRVMTNTPAKYGYGCAVVSYSADVSKEQKPLVNELISQVGKYVELP 176
           I  + +  S    V RVM NTP   G G + V+    V  EQ   V +L+S VG  +E+ 
Sbjct: 103 IAAMEESASAGLPVVRVMPNTPMLVGKGMSTVTKGRYVDAEQLEQVKDLLSTVGDVLEVA 162

Query: 177 EKNMDAATALVGSGPAFVXXXXXXXXXXXXXXXIPLQESKECAMKVLEGTVKMVEKSGAH 236
           E ++DA TA+ GS PA++               +P   +K+ A+   EG   M++++G  
Sbjct: 163 ESDIDAVTAMSGSSPAYLFLVTEALIEAGVNLGLPRATAKKLAVASFEGAATMMKETGKE 222

Query: 237 PSVLKHQVCTPGGTTIAGLCVMEEKGVKSGIINGVEEAARVASQLGQ 283
           PS L+  V +P GTT+A +  +EE G++       +  A  + +LG+
Sbjct: 223 PSELRAGVSSPAGTTVAAIRELEESGIRGAFYRAAQACADRSEELGK 269

>gi|3688282|emb|CAA09332| (AJ010739) pyrroline-5-carboxylate
           reductase [Clostridium sticklandii]
           Length = 266
           
 Score =  123 bits (306), Expect = 1e-27
 Identities = 82/285 (28%), Positives = 139/285 (48%), Gaps = 23/285 (8%)

Query: 1   MTYTLAILGCGVMGQALLSAIYNAPKAADETAAAFYPSKIITCNHDEPSAQQVTDLVETF 60
           M   +  +GCG M QA++SA+                SK+I  N    S +    L +  
Sbjct: 1   MDKKIGFIGCGNMAQAMISALVK--------------SKLIESNQIIVSNRSKNILEKMN 46

Query: 61  DESPNGIKVESTYGHNVSAVEEASVVLLGTKPFLAEEVLNGVK-SVIGGKLLISLAAGWT 119
            E   GI + +   +N+   E+  +V L  K  L E V+  +K SV   K+ +S+A G T
Sbjct: 47  KEY--GITIAA---NNIEVAEKCDIVFLAVKQNLYEMVMKEIKDSVTKDKIFVSIAPGKT 101

Query: 120 IDQLSQYTST---VCRVMTNTPAKYGYGCAVVSYSADVSKEQKPLVNELISQVGKYVELP 176
           ++ L  +      + R M NTP+    G   +  +++++ E+  L+ +LI   G    + 
Sbjct: 102 MEFLEAHLGAYAKILRTMPNTPSMVSEGMTAICPNSNIASEELELLVKLIESFGAVEIIE 161

Query: 177 EKNMDAATALVGSGPAFVXXXXXXXXXXXXXXXIPLQESKECAMKVLEGTVKMVEKSGAH 236
           EK  DA  A+ GS PA+V               +P  ++   A + + G+ KMV +S +H
Sbjct: 162 EKLFDAVVAVSGSSPAYVFMFIEAMADAAVIQGMPRAQAYRFAAQAVLGSAKMVLESKSH 221

Query: 237 PSVLKHQVCTPGGTTIAGLCVMEEKGVKSGIINGVEEAARVASQL 281
           P  LK  VC+PGGTTI  + V+EE+G++S +I  + + A+ + ++
Sbjct: 222 PGELKDMVCSPGGTTIEAVAVLEERGMRSAVIEAMRKCAQKSKEM 266

>gi|130972|sp|P17817|PROC_SOYBN PYRROLINE-5-CARBOXYLATE REDUCTASE
           (P5CR) (P5C REDUCTASE) >gi|99952|pir||S10186
           pyrroline-5-carboxylate reductase (EC 1.5.1.2) - soybean
           >gi|18724|emb|CAA34401| (X16352) pyrroline-5-carboxylate
           reductase (AA 1- 274) [Glycine max]
           Length = 274
           
 Score =  122 bits (304), Expect = 2e-27
 Identities = 85/283 (30%), Positives = 135/283 (47%), Gaps = 22/283 (7%)

Query: 2   TYTLAILGCGVMGQALLSAIYNAPKAADETAAAFYPSKIITCNHDEPSAQQVTDLVETFD 61
           +YTL  +G G M +++      +            PS+I T  H   + +      E+F 
Sbjct: 10  SYTLGFIGAGKMAESIARGAVRS--------GVLPPSRIRTAVHFNLARRGA---FESF- 57

Query: 62  ESPNGIKVESTYGHNVSAVEEASVVLLGTKPFLAEEVLNGVKSVIGG-KLLISLAAGWTI 120
               G+ V  +   N   V E+ VV+L  KP L ++V++ +  ++   KLL+S+AAG  +
Sbjct: 58  ----GVTVLPS---NDDVVRESDVVVLSVKPQLVKDVVSKLTPLLTKHKLLVSVAAGTKL 110

Query: 121 DQLSQYTST--VCRVMTNTPAKYGYGCAVVSYSADVSKEQKPLVNELISQVGKYVELPEK 178
             L ++       RVM NTPA  G   +V+S     ++E   ++ +L   +GK  +  EK
Sbjct: 111 KDLQEWAGNDRFIRVMPNTPAAVGQAASVMSLGGSATEEDGNIIAQLFGSIGKIWKAEEK 170

Query: 179 NMDAATALVGSGPAFVXXXXXXXXXXXXXXXIPLQESKECAMKVLEGTVKMVEKSGAHPS 238
             DA T L GSGPA+V               +P   S   A + + G   MV ++G HP 
Sbjct: 171 YFDAITGLSGSGPAYVYLAIEALADGGVAAGLPRDLSLSLASQTVLGAASMVSQTGKHPG 230

Query: 239 VLKHQVCTPGGTTIAGLCVMEEKGVKSGIINGVEEAARVASQL 281
            LK  V +PGGTTI G+  +E  G +  ++N V  AA+ + +L
Sbjct: 231 QLKDDVTSPGGTTITGIHELENGGFRGTLMNAVVAAAKRSREL 273

>gi|3024430|sp|O04016|PROC_ACTCH PYRROLINE-5-CARBOXYLATE REDUCTASE
           (P5CR) (P5C REDUCTASE) >gi|1928962 (U92287)
           pyrroline-5-carboxylate reductase [Actinidia deliciosa]
           Length = 278
           
 Score =  119 bits (295), Expect = 2e-26
 Identities = 80/283 (28%), Positives = 134/283 (47%), Gaps = 23/283 (8%)

Query: 2   TYTLAILGCGVMGQALLSAIYNAPKAADETAAAFYPSKIITCNHDEPSAQQVTDLVETFD 61
           TY L  +G G M +++   +  +            P+  I   H   + ++     E+F 
Sbjct: 13  TYKLGFIGAGKMAESIARGVVKS---------GVLPASRIRTAHLGSARREA---FESF- 59

Query: 62  ESPNGIKVESTYGHNVSAVEEASVVLLGTKPFLAEEVLNGVKSVIGGK-LLISLAAGWTI 120
               G+KV      N   VE++ V++   KP + +EV+  ++ ++  K LL+S+ AG  +
Sbjct: 60  ----GVKV---LDRNDQVVEDSDVIIFSVKPQIVKEVVLQLRPLLSEKQLLVSIVAGVKL 112

Query: 121 DQLSQYT--STVCRVMTNTPAKYGYGCAVVSYSADVSKEQKPLVNELISQVGKYVELPEK 178
            +L  +   S   RVM NTPA  G   +V+S  A  + E   L+ +L   +GK  +  EK
Sbjct: 113 KELEDWAGHSRFIRVMPNTPAAVGEAASVMSLGATATGEDGELITKLFGAIGKIWKADEK 172

Query: 179 NMDAATALVGSGPAFVXXXXXXXXXXXXXXXIPLQESKECAMKVLEGTVKMVEKSGAHPS 238
             DA T L GSGPA++               +P + +   A + + G   MV + G HP 
Sbjct: 173 LFDAVTGLSGSGPAYIFLAIEALADGGVAAGLPRELALGLASQTVLGAASMVARGGKHPG 232

Query: 239 VLKHQVCTPGGTTIAGLCVMEEKGVKSGIINGVEEAARVASQL 281
            LK  V + GGTTIAG+  +E+ G +  ++N V  A + + ++
Sbjct: 233 QLKDDVASAGGTTIAGIHELEKGGFRGTLMNAVVSATKRSQEI 275

>gi|886762 (U27806) pyrroline carboxylate reductase [Plasmodium
           falciparum]
           Length = 209
           
 Score =  115 bits (284), Expect = 5e-25
 Identities = 64/203 (31%), Positives = 103/203 (50%), Gaps = 3/203 (1%)

Query: 85  VVLLGTKPFLAEEVLNGVKSVIGGKLLISLAAGWTIDQLSQYTST---VCRVMTNTPAKY 141
           +++   KP +A  VLN +K  +  KLLIS+  G  I +L +   +   +  VM NTP   
Sbjct: 7   IIVCAVKPDIAGSVLNNIKPYLSSKLLISICGGLNIGKLEEMVGSENKIVWVMPNTPCLV 66

Query: 142 GYGCAVVSYSADVSKEQKPLVNELISQVGKYVELPEKNMDAATALVGSGPAFVXXXXXXX 201
           G G  +   + +V+   K  VN++ +  G   E+ EK+MD ATA+ G GPA+V       
Sbjct: 67  GEGSFIYCSNKNVNSTDKKYVNDIFNSCGIIHEIKEKDMDIATAISGCGPAYVYLFIESL 126

Query: 202 XXXXXXXXIPLQESKECAMKVLEGTVKMVEKSGAHPSVLKHQVCTPGGTTIAGLCVMEEK 261
                   +  + SK   ++ ++G+V+MV+KS      LK  + +PGG T  GL  +E+ 
Sbjct: 127 IDAGVKNGLSRELSKNLVLQTIKGSVEMVKKSDQPVQQLKDNIVSPGGITAVGLYSLEKN 186

Query: 262 GVKSGIINGVEEAARVASQLGQK 284
             K  ++N VE A   +  +G K
Sbjct: 187 SFKYTVMNAVEAACEKSKAMGSK 209

>gi|3832514 (AF098020) pyrroline 5-carboxylate reductase [Drosophila
           melanogaster]
           Length = 280
           
 Score =  111 bits (276), Expect = 4e-24
 Identities = 67/226 (29%), Positives = 116/226 (50%), Gaps = 13/226 (5%)

Query: 72  TYGHNVSAVEEASVVLLGTKPFLAEEVLNGVK------SVIGGKLLISLAAGWTIDQLSQ 125
           T   N   +E + +V +  KP +       +K      +    KL++S+ AG ++  L +
Sbjct: 55  TCDDNCMVLEHSDIVFICVKPHMLTPCAAQLKYKHVPSAKDASKLVVSVLAGTSLQTLEE 114

Query: 126 YTS-------TVCRVMTNTPAKYGYGCAVVSYSADVSKEQKPLVNELISQVGKYVELPEK 178
             S        V R M NT  + G GC V + +A VS      ++ +++ +G   ++PE 
Sbjct: 115 AFSFMGSSELKVIRTMPNTSMQVGEGCTVYTGNARVSHHDLEKIHLMLNALGLAQQVPES 174

Query: 179 NMDAATALVGSGPAFVXXXXXXXXXXXXXXXIPLQESKECAMKVLEGTVKMVEKSGAHPS 238
            +DA T + G GPAFV               +P Q + + A + L G  K V  +G HP+
Sbjct: 175 MIDAVTPVAGCGPAFVYTIIEALADGGVKQGVPRQMALQFAAQTLLGAAKTVLLTGKHPA 234

Query: 239 VLKHQVCTPGGTTIAGLCVMEEKGVKSGIINGVEEAARVASQLGQK 284
           VL+ +VC+PGG TI G+  +E+  ++S +IN VE++++ +++LG+K
Sbjct: 235 VLRDEVCSPGGATIVGVHELEKGNLRSTLINAVEKSSQRSAELGKK 280

>gi|3024442|sp|Q12641|PROC_NEUCR PYRROLINE-5-CARBOXYLATE REDUCTASE
           (P5CR) (P5C REDUCTASE) >gi|1362528|pir||S57863
           delta(1)-pyrroline-5-carboxylate reductase - Neurospora
           crassa >gi|924949 (U30317) D1-pyrroline-5-carboxylate
           reductase [Neurospora crassa]
           Length = 311
           
 Score =  108 bits (266), Expect = 6e-23
 Identities = 76/234 (32%), Positives = 112/234 (47%), Gaps = 31/234 (13%)

Query: 76  NVSAVEEASVVLLGTKPFLAEEVLN--GVKSVI----------GGKLLISLAAGWTIDQL 123
           NVSA  EA ++LLG KP++   +L+  G+K  +            K++IS+ AG T+  L
Sbjct: 70  NVSAAAEADIILLGCKPYMVSGLLSASGMKDALTVKHTEGHARSQKIIISICAGVTVPDL 129

Query: 124 SQYTST-----------VCRVMTNTPAKYGYGCAVVSYSADVSKEQKPLVNELIS----Q 168
            +               V R M NT +K      V++    V       V EL++    +
Sbjct: 130 ERVLREDVGLSADNLPIVVRAMPNTASKIRESMTVIN---TVDPPLPDTVTELLTWIFER 186

Query: 169 VGKYVELPEKNMDAATALVGSGPAFVXXXXXXXXXXXXXXXIPLQESKECAMKVLEGTVK 228
           +G+ V LP   MDA T+L  SG AF                +P  E+   A + + G   
Sbjct: 187 IGEVVYLPPHLMDACTSLCASGTAFFALMMEAAADGGVAMGLPRAEANRMAAQTMRGAAG 246

Query: 229 MVEKSGAHPSVLKHQVCTPGGTTIAGLCVMEEKGVKSGIINGVEEAARVASQLG 282
           +V + G HP++L+ +V TPGG TI GL V+EE GV++ +   V EA  VAS LG
Sbjct: 247 LVLE-GEHPAILREKVSTPGGCTIGGLLVLEEGGVRAAVARAVREATVVASLLG 299

>gi|1709791|sp|P54552|PROI_BACSU PYRROLINE-5-CARBOXYLATE REDUCTASE
           HOMOLOG 2 >gi|1303966|gnl|PID|d1013301 (D84432) YqjO
           [Bacillus subtilis] >gi|2634815|emb|CAB14312| (Z99116)
           similar to pyrroline-5-carboxylate reductase [Bacillus
           subtilis]
           Length = 278
           
 Score =  106 bits (262), Expect = 2e-22
 Identities = 72/283 (25%), Positives = 130/283 (45%), Gaps = 21/283 (7%)

Query: 5   LAILGCGVMGQALLSAIYNAPKAADETAAAFYPSKIITCNHDEPSAQQVTDLVETFDESP 64
           +  +G G M +A+++ I  +            P  I   N      +++ +L ET+   P
Sbjct: 4   IGFVGAGSMAEAMINGILQS--------GITKPEHIYITNRSND--ERLIELKETYSVRP 53

Query: 65  NGIKVESTYGHNVSAVEEASVVLLGTKPFLAEEVLNGVKSVIGGKLLISLAAGWTIDQLS 124
              K E              +++L  KP  A E ++ ++  I  +L+IS+ AG TI+ + 
Sbjct: 54  CRDKNEF--------FTHTDIIILAFKPKDAAESIDSIRPYIKDQLVISVLAGLTIETIQ 105

Query: 125 QYTS---TVCRVMTNTPAKYGYGCAVVSYSADVSKEQKPLVNELISQVGKYVELPEKNMD 181
            Y      V RVM NT A         S S + SK        L+  +G    + E+++D
Sbjct: 106 HYFGRKLAVIRVMPNTSAAIRKSATGFSVSTEASKNDIIAAKALLETIGDATLVEERHLD 165

Query: 182 AATALVGSGPAFVXXXXXXXXXXXXXXXIPLQESKECAMKVLEGTVKMVEKSGAHPSVLK 241
           A TA+ GSGPA+V               +  + +K   ++ + G   M+ +SG  P  L+
Sbjct: 166 AVTAIAGSGPAYVYRYIEAMEKAAQKVGLDKETAKALILQTMAGATDMLLQSGKQPEKLR 225

Query: 242 HQVCTPGGTTIAGLCVMEEKGVKSGIINGVEEAARVASQLGQK 284
            ++ +PGGTT AGL  +++   +  II+ +EE A+ ++++ ++
Sbjct: 226 KEITSPGGTTEAGLRALQDSRFEEAIIHCIEETAKRSAEIKEQ 268

>gi|130969|sp|P00373|PROC_ECOLI PYRROLINE-5-CARBOXYLATE REDUCTASE
           (P5CR) (P5C REDUCTASE) >gi|66088|pir||RDECC
           pyrroline-5-carboxylate reductase (EC 1.5.1.2) -
           Escherichia coli >gi|147359 (J01665) pyrroline
           carboxylate reductase [Escherichia coli] >gi|1657582
           (U73857) pyrroline-5-carboxylate reductase [Escherichia
           coli] >gi|1786585 (AE000145) pyrroline-5-carboxylate
           reductase [Escherichia coli]
           Length = 269
           
 Score =  106 bits (261), Expect = 2e-22
 Identities = 78/287 (27%), Positives = 134/287 (46%), Gaps = 23/287 (8%)

Query: 1   MTYTLAILGCGVMGQALLSAIYNAPKAADETAAAFYPSKIITCNHDEPSAQQVTDLVETF 60
           M   +  +GCG MG+A+L  +          +    P +I       PS  +V  L + F
Sbjct: 1   MEKKIGFIGCGNMGKAILGGLI--------ASGQVLPGQIWVYT---PSPDKVAALHDQF 49

Query: 61  DESPNGIKVESTYGHNVSAVEEASVVLLGTKPFLAEEVLNGVKSVIG-GKLLISLAAGWT 119
                GI    +    V+ +  A ++    KP +  +VL+ + S +    L++S+AAG T
Sbjct: 50  -----GINAAES-AQEVAQI--ADIIFAAVKPGIMIKVLSEITSSLNKDSLVVSIAAGVT 101

Query: 120 IDQLSQ---YTSTVCRVMTNTPAKYGYGCAVVSYSADVSKEQKPLVNELISQVGKYVELP 176
           +DQL++   +   + R M NTPA    G   V+ +A V+ E    V  +    G+   + 
Sbjct: 102 LDQLARALGHDRKIIRAMPNTPALVNAGMTSVTPNALVTPEDTADVLNIFRCFGEAEVIA 161

Query: 177 EKNMDAATALVGSGPAFVXXXXXXXXXXXXXXXIPLQESKECAMKVLEGTVKMVEKSGAH 236
           E  +     + GS PA+V               +P  ++ + A + + G+ KMV ++G H
Sbjct: 162 EPMIHPVVGVSGSSPAYVFMFIEAMADAAVLGGMPRAQAYKFAAQAVMGSAKMVLETGEH 221

Query: 237 PSVLKHQVCTPGGTTIAGLCVMEEKGVKSGIINGVEEAARVASQLGQ 283
           P  LK  VC+PGGTTI  + V+EEKG ++ +I  + +    + +L +
Sbjct: 222 PGALKDMVCSPGGTTIEAVRVLEEKGFRAAVIEAMTKCMEKSEKLSK 268

>gi|3878731|emb|CAA91943| (Z67995) similar to
           pyrroline-5-carboxylate reductase; cDNA EST EMBL:D73345
           comes from this gene; cDNA EST EMBL:D76386 comes from
           this gene; cDNA EST EMBL:D75293 comes from this gene;
           cDNA EST EMBL:C08387 comes from this gene; ...
           Length = 279
           
 Score =  105 bits (260), Expect = 3e-22
 Identities = 76/284 (26%), Positives = 129/284 (44%), Gaps = 22/284 (7%)

Query: 5   LAILGCGVMGQALLSAIYNAPKAADETAAAFYPSKIITCNHDEPSAQQVTDLVETFDESP 64
           +  +G G M QAL   + N+ +   +   A  P +                  E F +  
Sbjct: 3   IGFIGAGKMAQALARGLINSGRITADNIIASSPKRD-----------------EVFLDQC 45

Query: 65  NGIKVESTYGHNVSAVEEASVVLLGTKPFLAEEVLNGVKSVIGGK-LLISLAAGWTI--- 120
             + + +T+  N   V+++ VV L  KP    +V + +   +  + L++S+A G TI   
Sbjct: 46  KALGLNTTHD-NAEVVQKSDVVFLAVKPVHVSKVASEIAPALSKEHLVVSIALGITIRNI 104

Query: 121 DQLSQYTSTVCRVMTNTPAKYGYGCAVVSYSADVSKEQKPLVNELISQVGKYVELPEKNM 180
           + L    S V RVM NTP+    G +  +  +         V +L+S VG  VE+PE ++
Sbjct: 105 ESLLPTKSRVVRVMPNTPSVVRAGASAFAMGSACRDGDAETVEKLLSTVGFAVEVPEIHI 164

Query: 181 DAATALVGSGPAFVXXXXXXXXXXXXXXXIPLQESKECAMKVLEGTVKMVEKSGAHPSVL 240
           D  T L GSGP+++               +P   + + A   L G  KMV ++G HP+ L
Sbjct: 165 DPVTGLSGSGPSYMFAVIEGLADGGVKVGLPRDLALKLAAYTLLGAAKMVLETGIHPAQL 224

Query: 241 KHQVCTPGGTTIAGLCVMEEKGVKSGIINGVEEAARVASQLGQK 284
           K  V +P G+++ G+  +E  G+K  +++ VE A   +   G K
Sbjct: 225 KDDVQSPAGSSVYGMHKLESGGLKGVLMDAVEAATNRSRATGDK 268

>gi|417539|sp|P32322|PROC_HUMAN PYRROLINE-5-CARBOXYLATE REDUCTASE
           (P5CR) (P5C REDUCTASE) >gi|283246|pir||A41770
           pyrroline-5-carboxylate reductase (EC 1.5.1.2) - human
           >gi|189498 (M77836) pyrroline-5-carboxylate reductase
           [Homo sapiens]
           Length = 319
           
 Score =  102 bits (253), Expect = 2e-21
 Identities = 67/205 (32%), Positives = 97/205 (46%), Gaps = 7/205 (3%)

Query: 75  HNVSAVEEASVVLLGTKPFLAEEVLNGVKSVIGGK-LLISLAAGWTIDQLSQYTST---- 129
           HN   V+ + V+ L  KP +   +L+ + + I  + +++S AAG TI  + +  S     
Sbjct: 55  HNKETVQHSDVLFLAVKPHIIPFILDEIGADIEDRHIVVSCAAGVTISSIEKKLSAFRPA 114

Query: 130 --VCRVMTNTPAKYGYGCAVVSYSADVSKEQKPLVNELISQVGKYVELPEKNMDAATALV 187
             V R MTNTP     G  V +       E   L+ +L+S VG   E+ E  +DA T L 
Sbjct: 115 PRVIRCMTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSTVGFCTEVEEDLIDAVTGLS 174

Query: 188 GSGPAFVXXXXXXXXXXXXXXXIPLQESKECAMKVLEGTVKMVEKSGAHPSVLKHQVCTP 247
           GSGPA+                +P + +     + L G  KM+  S  HP  LK  V +P
Sbjct: 175 GSGPAYAFTALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSP 234

Query: 248 GGTTIAGLCVMEEKGVKSGIINGVE 272
           GG TI  L V+E  G +S +IN VE
Sbjct: 235 GGATIHALHVLESGGFRSLLINAVE 259

>gi|3041718|sp|P14383|PROH_BACSU PYRROLINE-5-CARBOXYLATE REDUCTASE
           HOMOLOG 1 >gi|2634242|emb|CAB13741| (Z99114) alternate
           gene name: yoxE [Bacillus subtilis]
           Length = 270
           
 Score =  102 bits (251), Expect = 4e-21
 Identities = 74/262 (28%), Positives = 121/262 (45%), Gaps = 22/262 (8%)

Query: 5   LAILGCGVMGQALLSAIYNAPKAADETAAAFYPSKIITCNHDEPSAQQVTDLVETFDESP 64
           +A +G G M + ++S I  A K   +            C  +  + +++T+L     E  
Sbjct: 19  VAFIGAGSMAEGMISGIVRANKIPKQNI----------CVTNRSNTERLTEL-----ELQ 63

Query: 65  NGIKVESTYGHNVSAVEEASVVLLGTKPFLAEEVLNGVKSVIGG-KLLISLAAGWT---I 120
            GIK       N   +E+  V++L  KP  AE  L+ +KS I   +L++S+ AG T   I
Sbjct: 64  YGIKGALP---NQLCIEDMDVLILAMKPKDAENALSSLKSRIQPHQLILSVLAGITTSFI 120

Query: 121 DQLSQYTSTVCRVMTNTPAKYGYGCAVVSYSADVSKEQKPLVNELISQVGKYVELPEKNM 180
           +Q       V RVM NT +  G     ++    VS++ K L   L+  +G+   + E  M
Sbjct: 121 EQSLLNEQPVVRVMPNTSSMIGASATAIALGKYVSEDLKKLAEALLGCMGEVYTIQENQM 180

Query: 181 DAATALVGSGPAFVXXXXXXXXXXXXXXXIPLQESKECAMKVLEGTVKMVEKSGAHPSVL 240
           D  T + GSGPA+                +  Q S+    + L G  KM+ ++G HP +L
Sbjct: 181 DIFTGIAGSGPAYFYYLMEFIEKTGEEAGLDKQLSRSIGAQTLLGAAKMLMETGEHPEIL 240

Query: 241 KHQVCTPGGTTIAGLCVMEEKG 262
           +  + +P GTT AGL  +++ G
Sbjct: 241 RDNITSPNGTTAAGLQALKKSG 262

>gi|2982885 (AE000676) pyrroline carboxylate reductase [Aquifex
           aeolicus]
           Length = 265
           
 Score =  102 bits (251), Expect = 4e-21
 Identities = 59/204 (28%), Positives = 108/204 (52%), Gaps = 5/204 (2%)

Query: 81  EEASVVLLGTKPFLAEEVLNGVKSVIGGKLLISLAAGWTIDQLSQYTST---VCRVMTNT 137
           + + VVL+  KP  ++EVL  +K   G  +++S+ AG +I+++ +       + RVM N 
Sbjct: 64  DNSDVVLVAVKPKDSQEVLQKLKDYKG--IILSIMAGVSIEKMEKILGKDKKIVRVMPNV 121

Query: 138 PAKYGYGCAVVSYSADVSKEQKPLVNELISQVGKYVELPEKNMDAATALVGSGPAFVXXX 197
               G G   ++ + ++S+E++  V EL+   G    + E+  DA TAL GSGPAFV   
Sbjct: 122 NVAVGSGVMAITDNGNLSEEERSKVEELLLSCGTLYRIEERLFDAFTALAGSGPAFVFSF 181

Query: 198 XXXXXXXXXXXXIPLQESKECAMKVLEGTVKMVEKSGAHPSVLKHQVCTPGGTTIAGLCV 257
                          +++   A+  + G+ K++++   +P+ L  +V +PGGTTI G+  
Sbjct: 182 IDALALAGVHQGFSYEQALRIALDTVMGSAKLLKEFQVNPNELIAKVTSPGGTTIEGIKY 241

Query: 258 MEEKGVKSGIINGVEEAARVASQL 281
           +EEKG K  ++  +   ++ A +L
Sbjct: 242 LEEKGFKGTVMECINRTSQKAKKL 265

>gi|143480 (M24523) ORF 257 proC protein (put.); putative [Bacillus
           subtilis]
           Length = 257
           
 Score = 94.4 bits (231), Expect = 8e-19
 Identities = 71/255 (27%), Positives = 116/255 (44%), Gaps = 22/255 (8%)

Query: 5   LAILGCGVMGQALLSAIYNAPKAADETAAAFYPSKIITCNHDEPSAQQVTDLVETFDESP 64
           +A +G G M + ++S I  A K   +            C  +  + +++ +L     E  
Sbjct: 19  VAFIGAGSMAEGMISGIVRANKIPKQNI----------CVTNRSNTERLAEL-----ELQ 63

Query: 65  NGIKVESTYGHNVSAVEEASVVLLGTKPFLAEEVLNGVKSVIGG-KLLISLAAGWT---I 120
            GIK  S    N   +E+  V++L  KP  AE  L+ +K+ I   +L++S+ AG T   I
Sbjct: 64  YGIKGASP---NQICIEDMDVLILAMKPKDAESALSSLKTRIQPHQLILSVLAGITTSFI 120

Query: 121 DQLSQYTSTVCRVMTNTPAKYGYGCAVVSYSADVSKEQKPLVNELISQVGKYVELPEKNM 180
           +Q       V RVM NT +  G     ++    VS++ + L   L+  +G+   + E  M
Sbjct: 121 EQSLLNQQPVVRVMPNTSSMIGASATAIALGKYVSEDLQKLAEALLGCMGEVYTIQENQM 180

Query: 181 DAATALVGSGPAFVXXXXXXXXXXXXXXXIPLQESKECAMKVLEGTVKMVEKSGAHPSVL 240
           D  T + GSGPA+                +  Q S+    + L G  KM+ ++G  P VL
Sbjct: 181 DIFTGIAGSGPAYFYYLMEFIEKTGEEAGLDKQLSRSIGAQTLLGAAKMLMETGEQPEVL 240

Query: 241 KHQVCTPGGTTIAGL 255
           +  + +P GTT AGL
Sbjct: 241 RDNITSPNGTTAAGL 255

>gi|1172630|sp|P43869|PROC_HAEIN PYRROLINE-5-CARBOXYLATE REDUCTASE
           (P5CR) (P5C REDUCTASE) >gi|1073986|pir||I64060
           delta-1-pyrroline-5-carboxylate reductase (proC) homolog
           - Haemophilus influenzae (strain Rd KW20) >gi|1573276
           (U32716) pyrroline-5-carboxylate reductase (proC)
           [Haemophilus influenzae Rd]
           Length = 271
           
 Score = 83.9 bits (204), Expect = 1e-15
 Identities = 63/195 (32%), Positives = 95/195 (48%), Gaps = 6/195 (3%)

Query: 71  STYGHNVSAVEEASVVLLGTKPFLAEEVLNGVKSV-IGGKLLISLAAGWTIDQLSQY--- 126
           +T  +NV +  +A VVLL  KP +  EV + + +V    KLLIS+AAG + ++L+     
Sbjct: 51  ATSENNVGSAIKAEVVLLAVKPQMMAEVCSPLSAVDFSDKLLISIAAGISTERLNALIPS 110

Query: 127 TSTVCRVMTNTPAKYGYGCAVVSYSADVSKEQKPLVNELISQVGKYVEL-PEKNMDAATA 185
             ++ RVM NTPA  G G A +    + S+  +    +L+  VG+ V +  E  M A TA
Sbjct: 111 VKSIVRVMPNTPALVGEGMAGLFAPKNTSENYRTFAQDLLGAVGRTVWVNDETQMHAVTA 170

Query: 186 LVGSGPAFVXXXXXXXXXXXXXXXIPLQESKECAMKVLEGTVKMV-EKSGAHPSVLKHQV 244
             GS PA+                I  + ++E   + + G  KMV E      S L+  V
Sbjct: 171 ASGSSPAYFFLMLEAMQKALIKMNIDEKTARELVQQSMLGAAKMVTENPQIALSTLRENV 230

Query: 245 CTPGGTTIAGLCVME 259
            + GGTT A L V +
Sbjct: 231 TSKGGTTAAALAVFD 245

>gi|1172631|sp|P46725|PROC_MYCLE PYRROLINE-5-CARBOXYLATE REDUCTASE
           (P5CR) (P5C REDUCTASE) >gi|2145969|pir||S72897
           pyrroline-5-carboxylate reductase (EC 1.5.1.2) -
           Mycobacterium leprae >gi|467049 (U00018) proC;
           B2168_C2_211 [Mycobacterium leprae]
           Length = 294
           
 Score = 82.3 bits (200), Expect = 3e-15
 Identities = 78/302 (25%), Positives = 126/302 (40%), Gaps = 48/302 (15%)

Query: 5   LAILGCGVMGQALLSAIYNAPKAADETAAAFYPSKIITCNHDEPSAQQVTDLVETFDESP 64
           +AI+G G +G+ALLS +  A +   +   A            E    +   L +T+    
Sbjct: 8   IAIIGGGSIGEALLSGLLRAGRQVKDLVVA------------ERMPDRARYLADTYSVLV 55

Query: 65  NGIKVESTYGHNVSAVEEASVVLLGTKPFLAEEVLN------GVKSVIGGKLLISLAAGW 118
             +           AVE A  V++  KP   E V+        V +    ++L+++AAG 
Sbjct: 56  TSV---------TDAVENAMFVVVAVKPTDVESVMGDLVQAAAVANDSAEQVLVTVAAGV 106

Query: 119 TIDQLSQYT---STVCRVMTNTPAKYGYGCAVVSYSADVSKEQKPLVNELISQVGKYVEL 175
           TI  L       + V R M N  A  G G  V++    V+ +Q   V  +   VG  + +
Sbjct: 107 TITYLESKLPAGTPVVRAMPNAAALVGAGVTVLAKGRFVTGQQFEDVLAMFDAVGGVLTV 166

Query: 176 PEKNMDAATALVGSGPAFVXXXXXXXXXXXXXXXIPLQESKECAMKVLEGTVKM------ 229
           PE  MDA TA+ GSGPA+                +  Q + E A + + G+  M      
Sbjct: 167 PESQMDAVTAVSGSGPAYFFLLVEALVDAGVAVGLTRQVATELAAQTMAGSAAMLLERMD 226

Query: 230 -------VEKSGAHPSV----LKHQVCTPGGTTIAGLCVMEEKGVKSGIINGVEEAARVA 278
                  V   GA   V    L+  + +PGGTT A L  +E  G++  +++   +AA++ 
Sbjct: 227 QDRHSAEVAPLGAQVDVPAAQLRATITSPGGTTAAALRELERGGLRM-VVDAAVQAAKIR 285

Query: 279 SQ 280
           S+
Sbjct: 286 SE 287

>gi|130971|sp|P22008|PROC_PSEAE PYRROLINE-5-CARBOXYLATE REDUCTASE
           (P5CR) (P5C REDUCTASE) >gi|77682|pir||JQ0418
           pyrroline-5-carboxylate reductase (EC 1.5.1.2) precursor
           - Pseudomonas aeruginosa (strain PAO) >gi|151510
           (M33557) delta-1-pyrroline-5-carboxylate reductase (EC
           1.5.1.2) [Pseudomonas aeruginosa]
           Length = 273
           
 Score = 81.1 bits (197), Expect = 8e-15
 Identities = 79/291 (27%), Positives = 124/291 (42%), Gaps = 29/291 (9%)

Query: 2   TYTLAILGCGVMGQALLSAIYNAPKAADETAAAFYPSKIITCNHDEPSAQQVTDLVETFD 61
           T  +A +G G M  +L+  +    +A    AA    S        +P A+Q   +   F 
Sbjct: 3   TPRIAFIGAGNMAASLIGGL----RAQGVPAAQIRAS--------DPGAEQRAKIAGEFA 50

Query: 62  ESPNGIKVESTYGHNVSAVEEASVVLLGTKPFLAEEVLNGVKSVIGGK-LLISLAAGWTI 120
                  VES    N  AV +A VV+L  KP   + V   +   +  + L++S+AAG   
Sbjct: 51  IDV----VES----NAEAVADADVVVLSVKPQAMKAVCQALAPALKPEQLIVSIAAGIPC 102

Query: 121 DQLSQYTST---VCRVMTNTPAKYGYGCAVVSYSADVSKEQKPLVNELISQVGKYVELP- 176
             L  +      V R M NTPA    G + +  +A VS  Q     +L+S VG  + L  
Sbjct: 103 ASLEAWLGQPRPVVRCMPNTPALLRQGASGLYANAQVSAAQCEQAGQLLSAVGIALWLDD 162

Query: 177 EKNMDAATALVGSGPAFVXXXXXXXXXXXXXXXIPLQESKECAMKVLEGTVKMVEKSGAH 236
           E  +DA TA+ GSGPA+                +  + +    ++   G  +M   S   
Sbjct: 163 EAQIDAVTAVSGSGPAYFFLLMQAMTDAGEKLGLSRETASRLTLQTALGAAQMALSSEVE 222

Query: 237 PSVLKHQVCTPGGTTIAGLCVMEEKG----VKSGIINGVEEAARVASQLGQ 283
           P+ L+ +V +P GTT A +   +  G    V+  +    + +A +A QLGQ
Sbjct: 223 PAELRRRVTSPNGTTEAAIKSFQANGFEALVEQALNAASQRSAELAEQLGQ 273

>gi|1709789|sp|P52053|PROC_VIBAL PYRROLINE-5-CARBOXYLATE REDUCTASE
           (P5CR) (P5C REDUCTASE) >gi|801881|gnl|PID|d1009698
           (D50472) pyrroline-5-carboxylate reductase [Vibrio
           alginolyticus]
           Length = 278
           
 Score = 77.3 bits (187), Expect = 1e-13
 Identities = 74/284 (26%), Positives = 121/284 (42%), Gaps = 28/284 (9%)

Query: 5   LAILGCGVMGQALLSAIYNAPKAADETAAAFYPSKIITCNHDEPSAQQVTDLVETFDESP 64
           +A +G G M +A++S +           A  YP++ IT     PS  +   L + F    
Sbjct: 12  IAFIGAGNMVRAIVSGL----------VANGYPAQNITAT--APSEARRLPLEQDF---- 55

Query: 65  NGIKVESTYGHNVSAVEEASVVLLGTKPFLAEEVLNGVKSV-IGGKLLISLAAGWTIDQL 123
            GI+  S    N+ A  EA VV+L  KP +  +V   ++++    KL+IS+AAG    +L
Sbjct: 56  -GIRTTSD---NIQAATEADVVVLSVKPQMMADVCKPLQAIDFTNKLVISIAAGINCSRL 111

Query: 124 SQYTST---VCRVMTNTPAKYGYGCAVVSYSADVSKEQKPLVNELISQVGK--YVELPEK 178
               +T   + RVM NTP++ G G + +     V++  K    EL+  VGK  +VE  E 
Sbjct: 112 DDMLATKLNLVRVMPNTPSQLGLGMSGLFAPIHVTEHDKAFAAELMEAVGKVCWVE-QES 170

Query: 179 NMDAATALVGSGPAFVXXXXXXXXXXXXXXXIPLQESKECAMKVLEGTVKM-VEKSGAHP 237
            ++   A  GS PA+                   + ++    +   G   M V       
Sbjct: 171 GINNVIAAAGSAPAYFFLFMEAMQAEAIAQGFDKESARLLVQQAALGAASMVVSNPETEL 230

Query: 238 SVLKHQVCTPGGTTIAGLCVMEEKGVKSGIINGVEEAARVASQL 281
           S L+  V + GGTT   L    E  +   +   ++ A   A ++
Sbjct: 231 STLRENVTSKGGTTAEALRTFNEHQLSDIVAKAMQAAVARAEEM 274

>gi|1709787|sp|Q11141|PROC_MYCTU PYRROLINE-5-CARBOXYLATE REDUCTASE
           (P5CR) (P5C REDUCTASE) >gi|1449298|emb|CAB00926|
           (Z77162) proC [Mycobacterium tuberculosis]
           Length = 295
           
 Score = 77.3 bits (187), Expect = 1e-13
 Identities = 75/304 (24%), Positives = 125/304 (40%), Gaps = 48/304 (15%)

Query: 5   LAILGCGVMGQALLSAIYNAPKAADETAAAFYPSKIITCNHDEPSAQQVTDLVETFDESP 64
           +AI+G G +G+ALLS +  A +   +   A            E    +   L +T+    
Sbjct: 8   IAIIGGGSIGEALLSGLLRAGRQVKDLVVA------------ERMPDRANYLAQTYS--- 52

Query: 65  NGIKVESTYGHNVSAVEEASVVLLGTKPFLAEEVLNGVKSVIGG-------KLLISLAAG 117
             + V S       AVE A+ V++  KP   E V+  + +           ++ +++ AG
Sbjct: 53  --VLVTSA----ADAVENATFVVVAVKPADVEPVIADLANATAAAENDSAEQVFVTVVAG 106

Query: 118 WTIDQLSQYT---STVCRVMTNTPAKYGYGCAVVSYSADVSKEQKPLVNELISQVGKYVE 174
            TI          + V R M N  A  G G   ++    V+ +Q   V+ L   VG  + 
Sbjct: 107 ITIAYFESKLPAGTPVVRAMPNAAALVGAGVTALAKGRFVTPQQLEEVSALFDAVGGVLT 166

Query: 175 LPEKNMDAATALVGSGPAFVXXXXXXXXXXXXXXXIPLQESKECAMKVLEGTVKMV---- 230
           +PE  +DA TA+ GSGPA+                +  Q + + A + + G+  M+    
Sbjct: 167 VPESQLDAVTAVSGSGPAYFFLLVEALVDAGVGVGLSRQVATDLAAQTMAGSAAMLLERM 226

Query: 231 --EKSGAH-----------PSVLKHQVCTPGGTTIAGLCVMEEKGVKSGIINGVEEAARV 277
             ++ GA+            S L+  V +PGGTT A L  +E  G +  +   V+ A   
Sbjct: 227 EQDQGGANGELMGLRVDLTASRLRAAVTSPGGTTAAALRELERGGFRMAVDAAVQAAKSR 286

Query: 278 ASQL 281
           + QL
Sbjct: 287 SEQL 290

>gi|4033772|sp|P27771|PROC_TREPA PYRROLINE-5-CARBOXYLATE REDUCTASE
           (P5CR) (P5C REDUCTASE) >gi|3323102 (AE001250)
           1-pyrroline-5-carboxylate reductase (proC) [Treponema
           pallidum]
           Length = 263
           
 Score = 76.5 bits (185), Expect = 2e-13
 Identities = 65/278 (23%), Positives = 114/278 (40%), Gaps = 29/278 (10%)

Query: 5   LAILGCGVMGQALLSAIYNAPKAADETAAAFYPSKIITCN-HDEPSAQQVTDLVETFDES 63
           +  LG G MG+AL   + +A         A   +++  C  + E    Q T L       
Sbjct: 3   VGFLGFGAMGRALAEGLVHA--------GALQAAQVYACALNQEKLRAQCTSL------- 47

Query: 64  PNGIKVESTYGHNVSAVEEASVVLLGTKPFLAEEVLNGVKSVIGGKLLISLAAGWTIDQL 123
             GI   ++       V+++  + L  KP     VL   +S   GK+LISLAAG +    
Sbjct: 48  --GIGACASVQE---LVQKSEWIFLAVKPSQISTVLRDRQS-FQGKVLISLAAGMSCAAY 101

Query: 124 SQYTSTV-------CRVMTNTPAKYGYGCAVVSYSADVSKEQKPLVNELISQVGKYVELP 176
               +           ++ N P +   G  +      +  ++   +  ++  V +   + 
Sbjct: 102 EALFAADPHQGIRHLSLLPNLPCQVARGVIIAEARHTLHHDEHAALLAVLRTVAQVEVVD 161

Query: 177 EKNMDAATALVGSGPAFVXXXXXXXXXXXXXXXIPLQESKECAMKVLEGTVKMVEKSGAH 236
                 A  + G  PAF                +   ++   A  +LEGT  +++ SG H
Sbjct: 162 TAYFAIAGVIAGCAPAFAAQFIEALADAGVRYGLARDQAYRLAAHMLEGTAALIQHSGVH 221

Query: 237 PSVLKHQVCTPGGTTIAGLCVMEEKGVKSGIINGVEEA 274
           P+ LK +VC+P G+TI G+  +EE+G++  +I+ V  A
Sbjct: 222 PAQLKDRVCSPAGSTIRGVLALEEQGLRRAVIHAVRAA 259

>gi|3024445|sp|Q20848|PROC_CAEEL PUTATIVE PYRROLINE-5-CARBOXYLATE
           REDUCTASE (P5CR) (P5C REDUCTASE) >gi|1326368 (U58750)
           coded for by C. elegans cDNA yk85c2.5;  Similar to
           carboxylate reductase. [Caenorhabditis elegans]
           Length = 299
           
 Score = 69.9 bits (168), Expect = 2e-11
 Identities = 53/217 (24%), Positives = 95/217 (43%), Gaps = 17/217 (7%)

Query: 84  SVVLLGTKPFLAEEVLNGVKSVIGGKLLISLAAGWTIDQLSQY------TSTVCRVMTNT 137
           ++ ++  KP + EEV++        + +IS+ AG  +  L+         +T+ R+M N 
Sbjct: 79  AIYVICVKPQVFEEVVSSWPVNSRPEFIISVMAGVPLKVLNAKLPFVSGNTTIVRLMPNV 138

Query: 138 PAKYGYGCAVVSYSADVSKEQKP----LVNELISQVGKYVELPEKNMDAATALVGSGPAF 193
            +  G G + + Y  +     +     L  E    VG    +PE+  + A A+ GS PA+
Sbjct: 139 ASSIGAGASTMCYEKNEKIMNQDSHIELAREFAECVGTVELIPERCFNPAMAIGGSSPAW 198

Query: 194 VXXXXXXXXXXXXXXXIPLQESKECAMKVLEGTVKMVEKSGA-------HPSVLKHQVCT 246
                           +   E+K  A + + G  +MV  S +       H   LK  VC+
Sbjct: 199 TFMYIESLADGAVAQGLGRAEAKRLAAQAVLGAAQMVLNSNSGFDIETQHFGSLKDMVCS 258

Query: 247 PGGTTIAGLCVMEEKGVKSGIINGVEEAARVASQLGQ 283
           PGGTTI G+  +E+ G +  ++  V  A+  A ++ +
Sbjct: 259 PGGTTIEGVRALEKNGFRYAVMEAVVAASTKADEMAK 295

>gi|1709788|sp|P54893|PROC_THETH PYRROLINE-5-CARBOXYLATE REDUCTASE
           (P5CR) (P5C REDUCTASE) >gi|540943|pir||JC2078
           pyrroline-5-carboxylate reductase (EC 1.5.1.2) - Thermus
           aquaticus (strain HB27) >gi|473555|gnl|PID|d1005542
           (D25413) pyrroline-5-carboxylate reductase [Thermus
           thermophilus]
           Length = 261
           
 Score = 69.1 bits (166), Expect = 3e-11
 Identities = 48/177 (27%), Positives = 78/177 (43%), Gaps = 5/177 (2%)

Query: 112 ISLAAGWTIDQLSQYTST--VCRVMTNTPAKYGYGCAVVSYSADVSK-EQKPLVNELISQ 168
           IS+ AG +   L++      V R M N     G     ++   +  + E       L + 
Sbjct: 87  ISIMAGISTSVLARRLDNRRVVRAMPNLAVVIGESSTALTALKEAREAEDLAFARALFAT 146

Query: 169 VGKYVELPEKNMDAATALVGSGPAFVXXXXXXXXXXXXXXXIPLQESKECAMKVLEGTVK 228
           VG   E+PE   DA T +  S PA++               +P   +   A   L  T +
Sbjct: 147 VGDVYEIPEHLFDAFTGMSASAPAYLAVVAEALADAGVKMGMPRALALRLAADALAATGE 206

Query: 229 MVEKSGAHPSVLKHQVCTPGGTTIAGLCVMEEKGVKSGIINGVEEAARVASQLGQKK 285
           +++  G HP+ +K +V +PGGTTI GL  +E + V++     VE A R   +LG+ +
Sbjct: 207 LLK--GRHPAQVKDEVASPGGTTIHGLHALEARAVRAAFYEAVEAATRRGHELGESE 261

>gi|98368|pir||B32807 hypothetical protein 199 - Bacillus subtilis
           (fragment)
           Length = 200
           
 Score = 67.1 bits (161), Expect = 1e-10
 Identities = 54/193 (27%), Positives = 90/193 (45%), Gaps = 22/193 (11%)

Query: 5   LAILGCGVMGQALLSAIYNAPKAADETAAAFYPSKIITCNHDEPSAQQVTDLVETFDESP 64
           +A +G G M + ++S I  A K   +            C  +  + +++ +L     E  
Sbjct: 19  VAFIGAGSMAEGMISGIVRANKIPKQNI----------CVTNRSNTERLAEL-----ELQ 63

Query: 65  NGIKVESTYGHNVSAVEEASVVLLGTKPFLAEEVLNGVKSVIGG-KLLISLAAGWT---I 120
            GIK  S    N   +E+  V++L  KP  AE  L+ +K+ I   +L++S+ AG T   I
Sbjct: 64  YGIKGASP---NQICIEDMDVLILAMKPKDAESALSSLKTRIQPHQLILSVLAGITTSFI 120

Query: 121 DQLSQYTSTVCRVMTNTPAKYGYGCAVVSYSADVSKEQKPLVNELISQVGKYVELPEKNM 180
           +Q       V RVM NT +  G     ++    VS++ + L   L+  +G+   + E  M
Sbjct: 121 EQSLLNQQPVVRVMPNTSSMIGASATAIALGKYVSEDLQKLAEALLGCMGEVYTIQENQM 180

Query: 181 DAATALVGSGPAF 193
           D  T + GSGPA+
Sbjct: 181 DIFTGIAGSGPAY 193

>gi|4155682 (AE001536) putative PYRROLINE-5-CARBOXYLATE REDUCTASE
           [Helicobacter pylori J99]
           Length = 257
           
 Score = 63.2 bits (151), Expect = 2e-09
 Identities = 48/172 (27%), Positives = 79/172 (45%), Gaps = 8/172 (4%)

Query: 109 KLLISLAAGWTIDQLSQYTSTV--CRVMTNTPAKYGYGC-AVVSYSADVSKEQKPLVNEL 165
           K ++S  AG   + LS   +++   + M N  +K+     AV   S   S  +K L   +
Sbjct: 86  KSVLSALAGVNFEALSNAINSLHYLKCMPNIASKFALSSTAVCEKSVAPSISEKAL--NI 143

Query: 166 ISQVGKYVELP-EKNMDAATALVGSGPAFVXXXXXXXXXXXXXXXIPLQESKECAMKVLE 224
           I   G  V +  E+ +D++ A  GS  AF+               +  ++S E      +
Sbjct: 144 IESFGNCVRVGNEEQVDSSVATNGSALAFLSLVASSLKDAGIREGLNAKDSLELVKMSFK 203

Query: 225 GTVKMVEKSGAHPSVLKHQVCTPGGTTIAGLCVMEEKGVKSGIINGVEEAAR 276
           G  K++EK    P ++  Q+CTP G TI GL V+E+KGV+   I    E+ +
Sbjct: 204 GFAKLLEKE--RPEMIIEQICTPKGATIEGLSVLEKKGVRGAFIKACHESVK 253

>gi|281467|pir||S27734 pyrroline-5-carboxylate reductase - Treponema
           pallidum >gi|155063 (M73825) 1-pyrroline-5-carboxylate
           reductase [Treponema pallidum]
           Length = 260
           
 Score = 62.8 bits (150), Expect = 2e-09
 Identities = 31/137 (22%), Positives = 62/137 (44%)

Query: 133 VMTNTPAKYGYGCAVVSYSADVSKEQKPLVNELISQVGKYVELPEKNMDAATALVGSGPA 192
           ++ N P +   G  +      +  ++   +  ++  V +   +       A  + G  PA
Sbjct: 116 LLPNLPCQVARGVIIAEARHTLHHDEHAALLAVLRTVAQVEVVDTAYFAIAGVIAGCAPA 175

Query: 193 FVXXXXXXXXXXXXXXXIPLQESKECAMKVLEGTVKMVEKSGAHPSVLKHQVCTPGGTTI 252
           F                +   ++   A  +LEGT  +++ SG HP+ LK +VC+P G+TI
Sbjct: 176 FAAQFIEALADAGVRYGLARDQAYRLAAHMLEGTAALIQHSGVHPAQLKDRVCSPAGSTI 235

Query: 253 AGLCVMEEKGVKSGIIN 269
            G+  +EE+G++  +I+
Sbjct: 236 RGVLALEEQGLRRAVIH 252

>gi|3024435|sp|O25773|PROC_HELPY PYRROLINE-5-CARBOXYLATE REDUCTASE
           (P5CR) (P5C REDUCTASE) >gi|2314308 (AE000621)
           pyrroline-5-carboxylate reductase (proC) [Helicobacter
           pylori 26695]
           Length = 257
           
 Score = 58.6 bits (139), Expect = 5e-08
 Identities = 47/175 (26%), Positives = 79/175 (44%), Gaps = 14/175 (8%)

Query: 109 KLLISLAAGWTIDQLSQYTSTV--CRVMTNTPAKYGYGCAVVSYSADVSKEQKPLVNE-- 164
           K ++S  AG     LS    ++   + M N  +K+      +S +A   K   PL+++  
Sbjct: 86  KSVLSALAGVGFKALSDAIDSLHYLKCMPNIASKFA-----LSSTAVCEKSPMPLISQKA 140

Query: 165 --LISQVGKYVELP-EKNMDAATALVGSGPAFVXXXXXXXXXXXXXXXIPLQESKECAMK 221
             +I   G  V +  E+ +DA+ A  GS  AF+               +  + S E    
Sbjct: 141 LSVIESFGNCVRVGHEELVDASVATNGSALAFLSLVANSLKDAGIREGLNARGSLELVKM 200

Query: 222 VLEGTVKMVEKSGAHPSVLKHQVCTPGGTTIAGLCVMEEKGVKSGIINGVEEAAR 276
             +G  K++EK    P ++  Q+CTP G TI GL V+E+KGV+   I    ++ +
Sbjct: 201 SFKGFAKLLEKE--RPEMIIEQICTPKGATIEGLSVLEKKGVRGAFIEACHKSVK 253

>gi|2632012|emb|CAA05571| (AJ002571) YkeA [Bacillus subtilis]
           >gi|2633645|emb|CAB13148| (Z99110) alternate gene name:
           yzcA; similar to pyrroline-5-carboxylate reductase
           [Bacillus subtilis]
           Length = 272
           
 Score = 52.7 bits (124), Expect = 3e-06
 Identities = 41/147 (27%), Positives = 72/147 (48%), Gaps = 4/147 (2%)

Query: 111 LISLAAGWTIDQLSQYTST-VCRVMTNTPAKYGYGCAVVSYSADVSKEQKPLVNELISQV 169
           ++S+AAG  +  L   T   + RV+    ++   G ++V +S  ++ E+K  +NEL+S  
Sbjct: 93  IVSIAAGVPLRLLEAETEAGISRVIPAITSEAEAGISLVVHSEALAAEKKERLNELLSVF 152

Query: 170 GKYVELPEKNMDAATALVGSGPAFVXX-XXXXXXXXXXXXXIPLQESKECAMKVLEGTVK 228
            +  E+ E N+D A+ L  S P F+                +  +E+ +  +  L GT K
Sbjct: 153 SRVREIKESNLDVASNLTSSAPGFIAAIFEELALSAVRNSSLSKEEAFDFLIHSLYGTGK 212

Query: 229 M-VEKSGAHPSVLKHQVCTPGGTTIAG 254
           M +EK+ +    L+ +V T GG T  G
Sbjct: 213 MLIEKNMSFEETLE-RVATKGGITGEG 238

>gi|628998|pir||S39862 comE Reverse-ORF - Bacillus subtilis
           >gi|289259 (L15202) comE Reverse-ORF [Bacillus subtilis]
           Length = 311
           
 Score = 52.3 bits (123), Expect = 4e-06
 Identities = 54/258 (20%), Positives = 106/258 (40%), Gaps = 21/258 (8%)

Query: 5   LAILGCGVMGQALLSAIYNAPKAADETAAAFYPSKIITCNHDEPSAQQVTDLVETFDESP 64
           +  +G G MG  L+ +   + KAAD       PS +   N     A  + +   + + + 
Sbjct: 41  IGFIGTGNMGTILIESFIES-KAAD-------PSNMTITNRTIEKALHIKNRYNSINVTE 92

Query: 65  NGIKVESTYGHNVSAVEEASVVLLGTKPFLAEEVL-NGVKSVIGGKLLISLAAGWTIDQL 123
           +  K+          V E  ++ +  KP     +L   +  +    +LIS+ +    +QL
Sbjct: 93  SLEKL----------VSENEMIFICVKPLDIYPLLARALPYLRKDHILISITSPVQTEQL 142

Query: 124 SQYTST-VCRVMTNTPAKYGYGCAVVSYSADVSKEQKPLVNELISQVGKYVELPEKNMDA 182
            QY    V RV+ +   +   G ++V++     +  K  +NEL+  + + +++       
Sbjct: 143 EQYVPCQVARVIPSITNRALAGVSLVTFGTSCGESAKAKINELMQHISQALQIESDITRV 202

Query: 183 ATALVGSGPAFVX-XXXXXXXXXXXXXXIPLQESKECAMKVLEGTVKMVEKSGAHPSVLK 241
           A+ +V  GPAF+                +  Q++     ++L G  K++E        L+
Sbjct: 203 ASDIVSCGPAFMSYLIQRFIDAAVSETSVSKQDAILMCKEMLVGMGKLLETELYTLPALQ 262

Query: 242 HQVCTPGGTTIAGLCVME 259
            +VC  GG T  G+  +E
Sbjct: 263 EKVCVKGGVTGEGIKALE 280

>gi|1705939|sp|P39696|CME4_BACSU COME OPERON PROTEIN 4
           Length = 273
           
 Score = 52.3 bits (123), Expect = 4e-06
 Identities = 54/258 (20%), Positives = 106/258 (40%), Gaps = 21/258 (8%)

Query: 5   LAILGCGVMGQALLSAIYNAPKAADETAAAFYPSKIITCNHDEPSAQQVTDLVETFDESP 64
           +  +G G MG  L+ +   + KAAD       PS +   N     A  + +   + + + 
Sbjct: 3   IGFIGTGNMGTILIESFIES-KAAD-------PSNMTITNRTIEKALHIKNRYNSINVTE 54

Query: 65  NGIKVESTYGHNVSAVEEASVVLLGTKPFLAEEVL-NGVKSVIGGKLLISLAAGWTIDQL 123
           +  K+          V E  ++ +  KP     +L   +  +    +LIS+ +    +QL
Sbjct: 55  SLEKL----------VSENEMIFICVKPLDIYPLLARALPYLRKDHILISITSPVQTEQL 104

Query: 124 SQYTST-VCRVMTNTPAKYGYGCAVVSYSADVSKEQKPLVNELISQVGKYVELPEKNMDA 182
            QY    V RV+ +   +   G ++V++     +  K  +NEL+  + + +++       
Sbjct: 105 EQYVPCQVARVIPSITNRALAGVSLVTFGTSCGESAKAKINELMQHISQALQIESDITRV 164

Query: 183 ATALVGSGPAFVX-XXXXXXXXXXXXXXIPLQESKECAMKVLEGTVKMVEKSGAHPSVLK 241
           A+ +V  GPAF+                +  Q++     ++L G  K++E        L+
Sbjct: 165 ASDIVSCGPAFMSYLIQRFIDAAVSETSVSKQDAILMCKEMLVGMGKLLETELYTLPALQ 224

Query: 242 HQVCTPGGTTIAGLCVME 259
            +VC  GG T  G+  +E
Sbjct: 225 EKVCVKGGVTGEGIKALE 242

>gi|1303795|gnl|PID|d1013130 (D84432) ComED [Bacillus subtilis]
           >gi|2635006|emb|CAB14502| (Z99117) alternate gene name:
           comD, comED; non-essential gene for competence [Bacillus
           subtilis]
           Length = 273
           
 Score = 51.2 bits (120), Expect = 8e-06
 Identities = 54/258 (20%), Positives = 105/258 (39%), Gaps = 21/258 (8%)

Query: 5   LAILGCGVMGQALLSAIYNAPKAADETAAAFYPSKIITCNHDEPSAQQVTDLVETFDESP 64
           +  +G G MG  L+ +   + KAAD       PS +   N     A  + +   + + + 
Sbjct: 3   IGFIGTGNMGTILIESFIES-KAAD-------PSNMTITNRTIEKALHIKNRYNSINVTE 54

Query: 65  NGIKVESTYGHNVSAVEEASVVLLGTKPFLAEEVL-NGVKSVIGGKLLISLAAGWTIDQL 123
           +  K+          V E  ++ +  KP     +L   +  +    +LIS+ +    +QL
Sbjct: 55  SLEKL----------VSENEMIFICVKPLDIYPLLARALPYLRKDHILISITSPVQTEQL 104

Query: 124 SQYTST-VCRVMTNTPAKYGYGCAVVSYSADVSKEQKPLVNELISQVGKYVELPEKNMDA 182
            QY    V RV+ +   +   G ++V++     +  K  +NEL+  +   +++       
Sbjct: 105 EQYVPCQVARVIPSITNRALAGVSLVTFGTSCGESAKAKINELMQHISHPLQIESDITRV 164

Query: 183 ATALVGSGPAFVX-XXXXXXXXXXXXXXIPLQESKECAMKVLEGTVKMVEKSGAHPSVLK 241
           A+ +V  GPAF+                +  Q++     ++L G  K++E        L+
Sbjct: 165 ASDIVSCGPAFMSYLIQRFIDAAVSETSVSKQDAILMCKEMLVGMGKLLETELYTLPALQ 224

Query: 242 HQVCTPGGTTIAGLCVME 259
            +VC  GG T  G+  +E
Sbjct: 225 EKVCVKGGVTGEGIKALE 242

>gi|2621992 (AE000865) pyrroline-5-carboxylate reductase
           [Methanobacterium thermoautotrophicum]
           Length = 253
           
 Score = 50.8 bits (119), Expect = 1e-05
 Identities = 43/196 (21%), Positives = 84/196 (41%), Gaps = 24/196 (12%)

Query: 1   MTYTLAILGCGVMGQALLSAIYNAPKAADETAAAFYPSKIITCNHDEPSAQQVTDLVETF 60
           M   +  LG G + + +L  +  A K          P +++ C+ DE S + + D     
Sbjct: 2   MEMRITFLGGGRVVRIILGGLQRAGKL---------PREVMVCDPDEDSLRSLEDEF--- 49

Query: 61  DESPNGIKVESTYGHNVSAVEEASVVLLGTKPFLAEEVLNGVKSVIGGKLLISLAAGWTI 120
                G+K  +       +  E  V+ L   P + ++VLN ++S     L++SLA    I
Sbjct: 50  -----GVKTSAD-----CSSMEGDVIFLALHPPVLKDVLNKMESPSPESLIVSLAPRIRI 99

Query: 121 DQLSQYTS--TVCRVMTNTPAKYGYGCAVVSYSADVSKEQKPLVNELISQVGKYVELPEK 178
           +++ Q      V RV+ N  +    G    S + +++     ++  L   +GK+ E+ E 
Sbjct: 100 EEIQQALDHPKVARVIPNALSLVNRGYNPFSAADELTGTDLEILQSLFEPLGKFPEVSED 159

Query: 179 NMDAATALVGSGPAFV 194
            ++A   +   GP ++
Sbjct: 160 KLEAYAVITAMGPTYL 175

>gi|2209378 (AF006720) ProH [Bacillus subtilis]
           Length = 99
           
 Score = 48.8 bits (114), Expect = 4e-05
 Identities = 21/71 (29%), Positives = 40/71 (55%)

Query: 213 QESKECAMKVLEGTVKMVEKSGAHPSVLKHQVCTPGGTTIAGLCVMEEKGVKSGIINGVE 272
           Q S+    + L G  KM+ ++G HP +L+  + +P GTT AGL  +++ G    I   ++
Sbjct: 15  QLSRSIGAQTLLGAAKMLMETGEHPEILRDNITSPNGTTAAGLQALKKSGGGEAISQAIK 74

Query: 273 EAARVASQLGQ 283
            AA+ + ++ +
Sbjct: 75  HAAKRSKEISE 85

  Database: nr
    Posted date:  Mar 13, 1999  7:20 PM
  Number of letters in database: 110,384,460
  Number of sequences in database:  361,503
  
Lambda     K      H
   0.313    0.130    0.363 

Gapped
Lambda     K      H
   0.270   0.0470    0.230 

Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 56932109
Number of Sequences: 361503
Number of extensions: 2110636
Number of successful extensions: 4646
Number of sequences better than 1.0e-03: 37
Number of HSP's better than  0.0 without gapping: 26
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 4588
Number of HSP's gapped (non-prelim): 38
length of query: 286
length of database: 110384460
effective HSP length: 59
effective length of query: 227
effective length of database: 89055783
effective search space: 20215662741
effective search space used: 20215662741
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 42 (21.9 bits)
S2: 103 (44.5 bits)