February 5, 1956

Dr. P. D. Skaar
Rio Lab
Cfild Spring HnDWr, L.I., 14.Y.

Dear Dave:

It wae thoughtful. pr^ gctu tn send the ma., and I wccs glad to @ over
it.  The simplest way t@ c.cd my c%~ntz WC e te mark ?.h carbm capy ink
izlk.  1 spotted G fz+w cases af lanE;us@ that P,P, antsrprioing student
cc!uld succeed in tiainterpreting, and an equally emall number of minor
verbosities, all indicated.  Frankly, X don't care far the %ipartitea
phr&sealOgy, as it reminds ze tW WOn Cf Tracy's shcpwern ido&s (?n
-kappa, a lcng time age, and it might evoke sirri?lar c%nNati@ns in
ethers. #by not twc-$?cuu, cr binary, or d%i, or interectie%s...?

As to the orodit line, the authcrahip is, c?f cQur~~,all yQars. HOWever,
I think it wW3.d be appr@priEta to indicate k;lxtre tke v@rk was d%e in the
wllcwing ways,  In the address to &frGn @Department Of Genetics, University
Of WiscOnsin, %disOn, UiscOnrain' and foetncrta thio to read
1. P&F@r ?biber   f-e tke Dcpartxent of Sanetics. The x%-k at !+?&Cison
(1351-1953) WES SuppOrtsd hy zrrlata frcn t.& WctiP?I;Gl ZZ.W+Z Ix&R&c,
(C-2157), P;lbl.iE I1eel.t.h Swk.s, 7.A fwr the Zlsaearsh C%tittee, Grd~ate
SchO@l, UnivaD6fty Cf -discc?ldn with f'unde allotted b;- tke wiscontsin
Alumni Research FWndatiW.

Also, can yOu arrange for UCI to have about 100 Of'tne reprints vhan they
@me back? We will gladly arrange to pay pro-rata ff?r them.

If you can spare a copy Of the final ~cP., I'd appreciate seeing it.

Esther's reply to yWr inquiry aboUt Mal-Lp2 must have cfleeed yQu.r
letter in the mails. We're a little behind Our Wark, what with being trane-
planted in Bact. Bldg- we should be moving back t0 a reINd8lhd lab in
Genetias in a c@aple of weeks. I'm a little afraid you'll be running dOwn
the garden path with the Malmutant~, since 60 many 1-i are involved, but
as Esther aaid yW(re welcOme to try yc)ur hand at it as far a8 she's concerned.
W%ldn@t S8--Sd be a cleaner system? Or the Vlt-Tr- (which stands On abOut
the same ground as Hal-Lgz?

After a lot Of fuss and feathers, it finally is clear to us that Hfr--1
(Cavalll) and -2+Hayes) are quite different in segregati% behavior.  What
fooled us SO long, Or rather gOt in tile way, was that Qur Old stWks (incll,
e.g., yoUr K-U) are uQdAy F+ reversiOna (sic), but we have that cleaned up
nW.  Alan Richter since picked up tw0 mOre Hfrts, and I'm well On in a hunt
for more, fr% UV*d Wb, using a replica tec~hniquu. @uite I number of divers
Hfrs have turned up, with all kinds @f segregation r&i%-- nQw c%es the
Wsrk W analyeing them.  Have yoU got a clean Hfr-23 (i.e., like the me
used by Jacob?) I can nW prwide this either as Bl-, prW%roph, Or 3+-S'


if yaUtre s$ all interested.  Y% also said @mething abOut a well-marked
Z- strain that was Vls. Will a Vlr do? If so, I can send E TLTi;"-Lac-P&l-
Ara-Xyl-Ga$- Ss Or Sr as yOu prefer. Are ybu and/Or Alan going Sn with
the tracer studless? I'm aspecially sCU+ry ycJu didngt get @n to F+ x F'- cr0sses.

   Which reminds me, I gOt a note frOE;I Jacob this week,, they are evidently
On much tha same treil M' the variaus -H~~FB, tMQ:h we dmtt qreeagn every detail,
naturally.  MC% he thinks Gat all crossing (of F+) ia dua to Xr Lnutants, which
888ms a little extreme to 133, and in fairly direct c%tradic?% to a Nuple Of
items Of fact we're still $&&ring 0% 14e ha6 8 fluctuati% ?.est (fertilii;y Of
a series of & cult-u;res), but if there ever were e e&se for Ei3sheliPJds (environ
menthl)Cbj~eti% this is it, since we kndw what aeratiQi does %C: c%patibiJity
phen*type/ (I had abat $he same dispersion in a 1946 wriii&,:nt, but w%ld
put that d%n tc envir%nent& variability too). I suppose ma c%&? test the
      1    .'
w cf the fluctuatinns, but it is 8 tricb sihlati~n, tiince aiq3st
certainly w nf the variable fertility of F+ cultur*~s :,k.Ll be due .Itfl Hfr
.?lutants.

I-EUQ *n Itichter's tail tn finish up these F experimnt@, sfi we C&I d&e
in ym-liters= ambiti@ns in that,directihn, NMAxIng at nJ,.l. !?as c+m *ut justice

-f-mere chemstatie experiments: there is a i~raerselecti~ exprFbi&nt in the
wfirks_tn see hn~ uelJ_F+ and 6 inncu&a c+upete tiith Pae qnthe*, z2nd that
sf?rzilca eid it. We've been busy as badgers, but 1tl.J. try te keep in mind the
backing nf Skaarim cnrrespnndence. D*ntt let ti&t deter y-z fmrn keeping in
Much with us. _       _ _                                               .
The iqres@.fins flna$ "u$ here t&t y&@re z&h batter settlad n@w at CSH;
ev@n te the pint *f y"ur deferring em8 j-b *ppnrtmities.  X: hope this is bntk
accurate end cnnpmisrl ifir put if net, let me 2mw @& and T*il discreetly
sc+2h the idea.

  Sincerely,
L