Dec. 4, 1929.

Dear 9r. Forkner,

       Your splendid. letter him3 been of' the greatest ~>leasure to E#;
first Let me coqT,ztulata you on Four work;  the fixiw of the KR in the
lymgh nodes is great and I arri so pleased that you got it over there to show
to Ashoff and mSkze him retGaUss the value of the vital reactions of cells.
10s to the slidee, Rnila did the sazze thin& all by himself. :Ilasn*t that
ZUllUSiXlg.  He drains.the excess on a blotting yaper md then puts into the
flame for a eecond Cmd the slides are perfectiun.   I had him s8nd the
50 to Dr. B UC- w!Uh whom I have been correspondiztg.   It seeRis that
Baorer has appointed a Cammission to study hygiene of childhood snd
W. BalmSkfm is at the bead of a subcomiittae of which I am a member and
Dr. Buckritan is secreta*.  The ~ornsafttes has not hzd a meeting as yet.

   In connection with this Committee we hnve stated the two new men on
the following program;  have mted rabbits h~vi&-; a si&l-r blood count
and are to count the blood of the parents 2nd the yo-ay once a week fob
six monthe,  Se think that will be an interesting follow u;j of your work on
the new born.  One litter will be used for bone mrrow counts once a
aonth so ae shall hnve a correllntion of blood and bone z-arrow,   That is the
problem for the two new men on the 6 t&f.

  You will think thnt we hove done nothin,? this fall when I tell you that
the fifth paper ia, only eoing to press this week;  nil of -them have been enormo
enormously improved this fall.    For the first three TM. Xenter wrote us
the followink: note,-  s I h,zae recd. your three papers on the chmo-histology
of the tubercle baillus with great interest :?nd plsnsure.  They %r8
models, ml I cotllEfmtul;tte youn Born and Forknern    Yasn*t that nice.
The Worth paper on the proteins was also much reworked;  the 304 is the
water soluble protein an3 `White now thinks that it is only of diwnostic
value;  neverthe lessl ve got 3 little increase in loxqevity with its Bex?im.
The ultrafiltrntfon method of prep:jring it of Salbert has proved unuasable
becaase it does pot free t%e prOtein of SqgX,   aohnson's method has to
be oubsti tutsd.   How we are hot foot after t!!e effects of the other protein
which is al:nline-soluble :;nd ::uite different structurally bemuse it has
different amino acids, or ot len.st different amino acid nitrogen.  i7e start
with it thiis raonth with the exlm'iment cornin,; p due with serum just after
~hristmarar.   llonn is now working on the fifth gq38r which covers 31.t of
the immuniolo~ical work since our first year here.   Analyzed aucording
to the M/I, index ~3 think the results quite remartible.   noan is to
:$ve the work at the 9 taff meetinf: this week mrl i % v~kzy &et pretty well
torn t.a pbbces yet I believe that yfe have really shown th$zt the cellular
factor has been pinned down to the %q/X, ratio 38 index.   The ta b 16 s
are quite ren?rkabfe.

     visemann is &ettiQ~ 'am interesting results with the embryonic juice;
the first animal showed I?. rem.s&mble lympho-pressor effect and if we get
lyiqhocytes under experimental control we may really have done something.
lku cmn imine th2t -2e are all excitement in the deg,&mmt.  !7r. Miller
is to stuQ ?lmm cells for his OVJX :Iroblam.   Ye found that 6 out of 8
of the rabbits @howed an increase in ?las~-~ cells in the qmentum after
intryxvritonesl 304 ~ni3 thRt is :vh?t he will re2e3.t rind they study th8


l,aR~wPaklirogWri~?~~~~~~w' the 5%~ second rabiAt of Dr. ?lisemn~s series kil;led
                3ressor effect on lyn;?~;ocyte%! but, n very
coqslex re.qction, so t.!;c plot thickens.

     Ttr. Flexner just callsdme Ikn -axd told me the good news that all seven
of our pnpers zre to be published together as a suglement to the JIM so they
vi11 all be bound together.   The five <are done, four alrex@ in ?nd the fifth
goes in this week.   This means tht all the papers will be held up for the
two of the &int C8110;  under t3e ciraumstzmnces I think th.?t it would be better
not to send them on to you in rtdv~nce b%CaUSe it woirld waste r?. full month.
Dr. goan hbs been writing exceedin, Lo a811 this f,all and I think that you csn
fulljr trust him nnd me too on the gapers  Since they :-Ere to go in wit?; the
!l?B groupi it s8em bea; t to rework the joint paper ki~&!# tying up the Work
with the T3 papers 2nd stressing the eoithelioid giant cell.   %%I1 the 1ctst
imper will &e yours alone 2nd will be just about as you h:zve written it,
emrcept sharpening ur, the st:ttexent of the fusion of cells as evidenced in th8
&Ant, cells in the blood.   You ail1 have tine to ansmr before the pz.pers
really go to >ress ,znti I vi.11 send the carbons immediately T/hen they are first
finished;  then if you want my changes they could. go in the @&ley if they
38re not too expenhlbeve,   If you ore unwilling to let them go to press
before yen hnve pnssed on them please reply ::.t once and ne will thn hold them
UP*   I thi& however tlmt ycm c.?in safely trust us in the mtter and that will
speed tlings for publication.  You onn ima&m that 36 are pretty anxious
to get them all out and off our hods.   I thi 3~ that tile first five have been
anazin,~ly i !l:lroved.

    I get frequent requests for your re-,rints znd hfzve sent thetn out nnd
k%:,t the Letters 2nd lists for you.

    I ,qms a talk at Tasmr We other d=y to ti;e Chemical Ds~mrtment in
whet the.:~ call chgmistqy week.  titer dinner I met a &W of the girls,
snd moung thenl !?iss W3ois.  -Jt was nice to see her agrrin.

    I haven't seen ?5rs. 3eesor yet but hops to at the luncheon which
comes on i)ecanber 17th.   I :am to oe introduced to the n'resident on the
11th &ich S0BmS $0 tne to 'ze +zM.&:: much more of' IT);J isor:& than it deserves,
The whole thing ekes me feel pretty humble end to wonder whether I shall
acca~cylish anything; whrth while after all.

    I[ shall be erqer for you next letter; you write such good ones.
I hope thrtt %t won 't be long before we can send the carbons 8ff to you.

    ?zery one in the ltiboratory sends greetings;  the new men have
both enjoyed your papers.

Cordially yoursl