IV.  DISEASES OF THE BLOOD AND BLOOD-FORMING ORGANS

Excludes:    anemia complicating pregnancy or puerperium (648.2)

280     Iron deficiency anemias

Anemia:                           Anemia:
    asiderotic                             Kelly-Paterson syndrome
    hypochromic                            Plummer-Vinson syndrome
    due to blood loss (chronic)            Sideropenic dysphagia
    posthaemorrhagic

Excludes:    acute posthaemorrhagic anemia (285.1)

281      Other deficiency anemias

281.0   Pernicious anemia

Anemia:
    Addison's
    Biermer's
    congenital pernicious
Congenital intrinsic factor deficiency

281.1   Other vitamin B12 deficiency anemia

Anemia:
    vegan's
    vitamin B12 deficiency (dietary)
    due to selective vitamin B12 malabsorption with proteinuria
Syndrome:
    Imerslund's
    Imerslund-Grsbeck

281.2   Folate-deficiency anemia

Folate or folic acid deficiency anemia:
    NOS
    dietary
    drug-induced
Nutritional megaloblastic anemia

Use additional E code, if desired, to identify drug

281.3   Other specified megaloblastic anemias not elsewhere classified

281.4   Protein-deficiency anemia

Amino-acid-deficiency anemia

281.8   Anemia associated with other specified nutritional deficiency

Scorbutic anemia
                          ICD-9/ch04.TXT - pg. 1                             U

281.9   Unspecified

Anemia:
    megaloblastic NOS
    nutritional NOS
    simple chronic

282     Hereditary hemolytic anemias

282.0   Hereditary spherocytosis

Acholuric (familial) jaundice
Congenital spherocytosis
Minkowski-Chauffard syndrome

282.1   Hereditary elliptocytosis

Elliptocytosis (congenital)
Ovalocytosis (congenital) (hereditary)

282.2   Anemias due to disorders of glutathione metabolism

Anemia:
    enzyme-deficiency, drug induced
    erythrocytic glutathione deficiency
    glucose-6-phosphate dehydrogenase [G-6-PD] deficiency
    glutathione-reductase deficiency
    hemolytic nonspherocytic (hereditary), type I
Favism

282.3   Other hemolytic anemias due to enzyme deficiency

Anemia:
    hemolytic nonspherocytic (hereditary), type II
    hexokinase deficiency
    pyruvate-kinase [PK] deficiency
    triose phosphate isomerase deficiency

282.4   Thalassemias

Cooley's anemia
Mediterranean anemia (with other hemoglobinopathy)
Sickle-cell thalassemia
Thalassemia (alpha) (beta) (intermedia) (major) (minor) (mixed) (trait)
    (with other hemoglobinopathy)

282.5   Sickle-cell trait

Hb-AS genotype
Hemoglobin S [Hb-S] trait
Heterozygous:
    hemoglobin S
    Hb-S
                          ICD-9/ch04.TXT - pg. 2

Excludes:    with other hemoglobinopathy (282.6-)
             with thalassemia (282.4)

282.6   Sickle-cell anemia

Hb-S disease                      Sickle-cell/Hb-C disease
Hb-S/Hb-C disease                 Sickle-cell/Hb-D disease
Hb-S/Hb-D disease                 Sickle-cell/Hb-E disease
Hb-S/Hb-E disease

Excludes:    sickle-cell thalassemia (282.4)

282.7   Other hemoglobinopathies

Abnormal hemoglobin NOS           Hemoglobinopathy NOS
Congenital Heinz-body anemia      Hereditary persistence of fetal
Disease:                               hemoglobin [HPFH]
    Hb-C                          Unstable hemoglobin hemolytic disease
    Hb-D
    Hb-E

Excludes:    familial polycythemia (289.6)
             Hb-M disease (289.7)
             high-oxygen-affinity hemoglobin (289.0)

282.8   Other

Stomatocytosis

282.9   Unspecified

Hereditary hemolytic anemia NOS

283     Acquired hemolytic anemias

283.0   Autoimmune hemolytic anemias

Autoimmune hemolytic disease (cold type) (warm type)
Chronic cold hemagglutinin disease
Cold agglutinin disease or hemoglobinuria
Hemolytic anemia:
    cold type (secondary) (symptomatic)
    warm type (secondary) (symptomatic)

Excludes:    Evans' syndrome (287.3)
             hemolytic disease of newborn (773.-)

283.1   Non-autoimmune hemolytic anemias

Hemolytic anemia:                 Hemolytic anemia:
    mechanical                        toxic
    microangiopathic              Hemolytic-uraemic syndrome

                          ICD-9/ch04.TXT - pg. 3

Use additional E code, if desired, to identify cause

283.2   Hemoglobinuria due to hemolysis from external causes

Hemoglobinuria:
    from exertion
    march
    paroxysmal (cold) (nocturnal)
    due to other hemolysis
Marchiafava-Micheli syndrome

Use additional E code, if desired, to identify cause

283.9   Unspecified

Acquired hemolytic anemia NOS     Chronic idiopathic hemolytic anemia

284     Aplastic anemia

284.0   Constitutional aplastic anemia

Aplasia, (pure) red cell:         Blackfan-Diamond syndrome
    congenital                    Familial hypoplastic anemia
    of infants                    Fanconi's anemia
    primary                       Pancytopenia with malformations

284.8   Other

Aplastic anemia (due to):         Pancytopenia (acquired)
    drugs                         Red cell aplasia (acquired)
    infection                          (adult) (pure) (with thymoma)
    radiation
    toxic

Use additional E code, if desired, to identify cause

284.9   Unspecified

Anemia:                           Medullary hypoplasia
    aplastic (idiopathic) NOS
    hypoplastic NOS

285     Other and unspecified anemias

285.0   Sideroblastic anemia

Anemia:                           Anemia, sideroblastic
    pyridoxine-responsive              primary
    sidero-achrestic                   refractory
    sideroblastic                      secondary (drug-induced)
         acquired                           (due to disease)
         congenital                    sex-linked hypochromic
         hereditary                    vitamin B6-responsive
                          ICD-9/ch04.TXT - pg. 4

Use additional E code, if desired, to identify cause if drug-induced

285.1   Acute posthemorrhagic anemia

285.8   Other specified anemias

Anemia:
    dyserythropoietic (congenital)
    dyshematopoietic (congenital)
    leukoerythroblastic
Infantile pseudoleukemia

285.9   Anemia, unspecified

286     Coagulation defects

286.0   Congenital factor VIII disorder

Factor VIII (functional)          Hemophilia:
    deficiency                        NOS
                                      A

Excludes:    factor VIII deficiency with vascular defect (286.4)

286.1   Congenital factor IX disorder

Christmas disease                 Hemophilia B
Deficiency:
    factor IX (functional)
    plasma thromboplastin component [PTC]

286.2   Congenital factor XI deficiency

Hemophilia C
Plasma thromboplastin antecedent [PTA] deficiency

286.3   Congenital deficiency of other clotting factors

Congenital afibrinogenemia        Deficiency:
Deficiency of factor:                 AC globulin
    I or fibrinogen                   proaccelerin
    II or prothrombin             Disease:
    V or labile                       Owren's
    VII or stable                     Stuart-Prower
    X or Stuart-Prower            Dysfibrinogenemia (congenital)
    XII or Hageman                Hypoproconvertinemia
    XIII or fibrin stabilizing

286.4   von Willebrand's disease

Angiohemophilia
Factor VIII deficiency with vascular defect
Vascular hemophilia
                          ICD-9/ch04.TXT - pg. 5

Excludes:    factor VIII deficiency:
                  NOS (286.0)
                  with functional defect (286.0)
             hereditary capillary fragility (287.8)

286.5   Hemorrhagic disorder due to circulating anticoagulants

Hyperheparinemia
Increase in:
    anti-VIIIa
    anti-IXa
    anti-Xa
    anti-XIa
    antithrombin
Systemic lupus erythematosus inhibitor

Use additional E code, if desired, to identify any administered anticoagulant

286.6   Defibrination syndrome

Afibrinogenemia, acquired
Consumption coagulopathy
Diffuse or disseminated intravascular coagulation
Fibrinolytic hemorrhage, acquired
Purpura:
    fibrinolytic
    fulminans

Excludes:    complicating abortion, pregnancy or the puerperium
                  (634-638 with fourth digit .1, 639.1, 641.3, 666.3)
             disseminated intravascular coagulation in newborn (776.2)

286.7   Acquired coagulation factor deficiency

Deficiency of coagulation factor due to:
    liver disease
    vitamin K deficiency

Excludes:    vitamin K deficiency of newborn (776.0)

286.9   Other and unspecified coagulation defects

Defective coagulation NOS
Deficiency, coagulation factor NOS
Delay, coagulation
Disorder:
    coagulation
    hemostasis
Prolongation of time of:
    bleeding
    coagulation

                          ICD-9/ch04.TXT - pg. 6

Excludes:    complicating abortion, pregnancy or the puerperium
                  (634-638 with fourth digit .1, 639.1, 641.3, 666.3)

287     Purpura and other hemorrhagic conditions

Excludes:    hemorrhagic thrombocythemia (238.7)
             purpura fulminans (286.6)

287.0   Allergic purpura

Purpura:
    anaphylactoid
    Henoch (-Schnlein)
    nonthrombocytopenic:
         hemorrhagic
         idiopathic
Vascular purpura
Vasculitis, allergic

287.1   Qualitative platelet defects

Thrombasthenia (hemorrhagic) (hereditary)
Thrombocytopathy

Excludes:    von Willebrand's disease (286.4)

287.2   Other nonthrombocytopenic purpuras

Purpura:
    NOS
    senile
    simplex

287.3   Primary thrombocytopenia

Megakaryocytic hypoplasia         Thrombocytopenia:
Purpura, thrombocytopenic             congenital
    congenital                        hereditary
    hereditary                        primary
    idiopathic

287.4   Secondary thrombocytopenia

Thrombocytopenia (due to):
    dilutional
    drugs
    extracorporeal circulation of blood
    massive blood transfusion
    platelet alloimmunization

Use additional E code, if desired, to identify cause

287.5   Thrombocytopenia, unspecified
                          ICD-9/ch04.TXT - pg. 7

287.8   Other specified hemorrhagic conditions

Capillary fragility (hereditary)
Vascular pseudohemophilia

287.9   Unspecified hemorrhagic conditions

288     Diseases of white blood cells

288.0   Agranulocytosis

Agranulocytic angina
Infantile genetic agranulocytosis
Kostmann's syndrome
Neutropenia:
    NOS
    cyclic
    drug-induced
    periodic
    splenic (primary)
    toxic
Neutropenic splenomegaly

Use additional code, if desired, to identify drug

288.1   Functional disorders of neutrophils polymorphonuclears

Chronic (childhood) granulomatous disease
Congenital dysphagocytosis
Progressive septic granulomatosis

288.2   Genetic anomalies of leucocytes

Anomaly (granulation) (granulocyte) or syndrome:
    Alder's
    Chediak-Steinbrink
    May-Hegglin
    Pelger-Hut
Hereditary:
    hypersegmentation
    hyposegmentation
    leukomelanopathy

288.3   Eosinophilia

Eosinophilia
    allergic
    hereditary

Excludes:    pulmonary eosinophilia (518.3)

288.8   Other

                          ICD-9/ch04.TXT - pg. 8

Leukemoid reaction                Lymphocytosis (symptomatic)
    lymphocytic                   Lymphopenia
    monocytic                     Monocytosis (symptomatic)
    myelocytic                    Plasmacytosis
Leukocytosis

Excludes:    immunity disorders (279.-)

288.9   Unspecified

289     Other diseases of blood and blood-forming organs

289.0   Secondary polycythemia

Polycythemia:                     Polycythemia, due to
    acquired                          erythropoietin
    due to:                           hypoxemic
         fall in plasma volume        nephrogenous
         high altitude                relative
    emotional                         stress

Excludes:    polycythemia neonatorum (776.4)
             polycythemia vera (238.4)

289.1   Chronic lymphadenitis

Chronic:
    adenitis, any lymph node except mesenteric
    lymphadenitis, any lymph node except mesenteric

Excludes:    acute lymphadenitis (683)
                  mesenteric (289.2)
             enlarged glands NOS (785.6)

289.2   Nonspecific mesenteric lymphadenitis

Mesenteric lymphadenitis (acute) (chronic)

289.3   Lymphadenitis, unspecified, except mesenteric

289.4   Hypersplenism

289.5   Other diseases of spleen

Atrophy of spleen                 Chronic congestive splenomegaly
Cyst of spleen                    Fibrosis of spleen:
Infarction of spleen                NOS
Rupture, nontraumatic of spleen   Perisplenitis

Excludes:    splenomegaly NOS (789.2)

289.6   Familial polycythemia

                          ICD-9/ch04.TXT - pg. 9

Familial:
    benign polycythemia
    erythrocytosis

289.7   Methemoglobinemia

Congenital NADH-methemoglobin-reductase deficiency
Hemoglobin M disease
Methemoglobinemia:
    NOS
    acquired (with sulfhemoglobinemia)
    hereditary
    toxic

Use additional E code, if desired, to identify cause

289.8   Other

289.9   Unspecified

                          ICD-9/ch04.TXT - pg. 10