MORPHINE
  SciTegic05180412282D

 22 26  0  0  1  0            999 V2000
   -0.8172   -0.6690    0.0000 C   0  0  2  0  0  0
   -0.7414    0.6172    0.0000 C   0  0
    0.3138   -1.5034    0.0000 C   0  0  2  0  0  0
   -2.0517   -1.0966    0.0000 C   0  0  1  0  0  0
   -0.4621   -1.9759    0.0000 C   0  0
   -1.9621    1.2000    0.0000 C   0  0
    0.4552    1.3034    0.0000 C   0  0
    1.5966   -0.9172    0.0000 C   0  0  1  0  0  0
    0.1586   -2.9276    0.0000 C   0  0
   -2.9034    0.1069    0.0000 O   0  0
   -2.3310   -2.5172    0.0000 C   0  0  2  0  0  0
    0.9207   -2.6586    0.0000 C   0  0
   -2.0655    2.6690    0.0000 C   0  0
    1.6828    0.5276    0.0000 C   0  0
    0.4552    2.7586    0.0000 C   0  0
    2.4724   -1.9931    0.0000 N   0  0
   -1.2069   -3.4690    0.0000 C   0  0
   -3.6931   -2.9966    0.0000 O   0  0
   -0.8276    3.4655    0.0000 C   0  0
   -3.3310    3.3000    0.0000 O   0  0
    3.8759   -2.3414    0.0000 C   0  0
    0.1103   -0.2069    0.0000 H   0  0
  1  2  1  0
  1  3  1  0
  1  4  1  0
  1  5  1  1
  2  6  1  0
  2  7  2  0
  3  8  1  0
  3  9  1  0
  4 10  1  6
  4 11  1  0
  5 12  1  0
  6 13  2  0
  7 14  1  0
  7 15  1  0
  8 16  1  1
  9 17  2  0
 11 18  1  6
 13 19  1  0
 13 20  1  0
 16 21  1  0
  6 10  1  0
  8 14  1  0
 11 17  1  0
 12 16  1  0
 15 19  2  0
  3 22  1  1
M  END
> <Name>
MORPHINE

> <Analgesic>
Active

> <RNEXTREG>
MORPHINE

> <MOL.WEIGHT>
285.341

> <UPD.CODE>
1990.1-1999.1

> <RN>
MORPHINE

> <CAS>
57-27-2

> <MF>
C17 H19 N O3

> <PT>
ANALGESICS; NARCOTICS; SEDATIVES

> <MA>
OPIOID-MU; OPIOID-KAPPA; OPIOID-SIGMA

> <SS>
ALKALOID; MORPHINAN; BENZOFURAN; ISOBENZOFURAN; COND.RING; PHENOL; OLEFIN;
 AMINOALCOHOL

> <USAN>
MORPHINE                               USAN

> <APP>
MORPHINE                               BAN

> <TRADE>
DOLCONTIN                              PHARMACIA           NO
DUROMORPH                              LAB.APPL.BIOL.      GB
MORFIN                                 NAF                 NO
MORPHINE-HP                            SABEX               CA
MS-CONTIN                              CHINOIN             IT
NEPENTHE                               EVANS               GB
OPIUM                                  LILLY               US

> <OTHER>
AMPHIOLEN
CARPUJECT
MECONIUM
MORFINE
MORPHIUM
MST-10-CONTINUS-RETARD
MST-CONTINUS
MST3-CONTINUS
OSPALIVINA
PANTOPON
ROXANOL

> <IU>
GASTROENTEROPATHY: diarrhea; INFECTION,BACT.: tetanus; MENTAL-DISORDER:
pain-associated-anxiety; PNEUMOPATHY: pulmonary-edema; RESPIRATION-DISORDER:
dyspnea of left-ventricular-failure; MISC: anesthesia (adjunct); cough;
insomnia due to pain; myocard.infarct.pain; neoplasm-pain; pain;
postoperative-pain.

> <PW>
Neonates; premature-infants; pregnancy; elderly; lactation; debilitation;
hypothyroidism; hypoadrenalism; hepatopathy; nephropathy;
prostate-hypertrophy; shock; obstructive-bowel-disorder; myasthenia-gravis;
with or within 14 days of MAO-inhibitors; may lead to dependence; the euphoric
activity of morphine has led to its abuse; administration of opioid analgesics
during labor may cause respirat.depression in the neonate.

> <CI>
Pheochromocytoma; respirat.depression; acute-alcoholism; head-injury;
intracranial-hypertension; preoperatively in children under 1 yr; during
bronchial-asthma attack; heart-failure secondary to pneumopathy.

> <IA>
Alcohol; amitriptyline; clomipramine; CNS-depressants; MAO-inhibitors;
phenothiazine-derivatives; sedatives; tricyclic-antidepressants.

> <AE>
ADDICTION; ALLERGY: +SKIN-DISEASE: urticaria (high-dosage); +MISC: anaphylaxis
(high-dosage); BILIARY-TRACT-DISEASE: biliary-tract-spasm; CARDIOPATHY:
arrhythmia; bradycardia; palpitations; CEREBROVASCULAR-DISEASE:
intracranial-hypertension; ENCEPHALOPATHY: coma (high-dosage); seizure
(high-dosage); EYE-DISEASE: miosis; GASTROENTEROPATHY: constipation; emesis;
HEPATOPATHY: elevated-hepatic-enzymes (high-dosage); MENTAL-DISORDER:
confusion; MOUTH-DISEASE: xerostomia; MYOPATHY: musc.spasm (high-dosage);
ORL-DISEASE: vertigo; PERIPHERAL-NERVE-DISEASE: orthostatic-hypotension;
urinary-retention; RESPIRATION-DISORDER: respirat.depression (high-dosage);
SKIN-DISEASE: contact-dermatitis (high-dosage); URINARY-TRACT-DISEASE:
ureteric-spasm; VASCULAR-DISEASE: shock (high-dosage); MISC: drowsiness;
exitus (high-dosage); flushing; hypothermia; injection-site-irritation;
injection-site-pain; mood-changes; nausea; pruritus; restlessness;
sexual-disorder (high-dosage); sweating.

> <COMB.PREP>
CHLOROPECT                             LASER               ZA
( + kaolin + pectin + bismuth-subcarbonate + chloroform )
COLLODYNE                              UNIVERSAL           ZA
( + kaolin + pectin + bismuth-subcarbonate + chloroform )
DIASTAT                                MER-NATIONAL        ZA
( + streptomycin sulfate + phthalylsulfathiazole + atropa belladonna
+ chloroform + kaolin + pectin )
ENTERODYNE                             MER-NATIONAL        ZA
( + bismuth-carbonate + calcium-carbonate + chloroform + ammonia
+ peanut-oil + clove-oil + cardamom + catechu-tincture + cinnamon
+ cinnamon-oil )
NEPENTHE                               EVANS-MEDICAL       GB
( + opium )

> <Molecular_Weight>
285.345

> <MOLNAME>
MORPHINE

$$$$