# CURRICULUM VITAE

[Name]{.underline}: Ana M. Gamero

[Date and Place of Birth]{.underline}: August 17, 1968; Lima, Peru

[Citizenship]{.underline}: United States

[Marital Status]{.underline}: Single

[Education]{.underline}:

1990 B.S. (Biology), University of South Florida,

Tampa, Florida

1996 Ph.D. (Medical Microbiology and Immunology)

University of South Florida, Tampa, Florida

Mentor: Julie Y. Djeu

[Brief Chronology of Employment]{.underline}:

1997-2001 Post-Doctoral Research Fellow

The Cleveland Clinic Foundation, Cleveland, Ohio

Mentor: Andrew C. Larner

2001-2003 Research Associate Staff

The Cleveland Clinic Foundation, Cleveland, Ohio

2003-Present National Cancer Institute Scholar

Cellular and Molecular Immunology Section, Laboratory of Experimental
Immunology,

National Cancer Institute -- Frederick,

Frederick, MD

[Grants/Awards]{.underline}:

1995-1996 American Society of Hematology Pre-Doctoral Student Travel
Award

1996 American Association for Cancer Research Minority Scholar Award

1998-2001 NIH Post-Doctoral Research Service Award

1998-2004 International Society for Interferon and Cytokine Research
(ISICR) Travel Award

2002 Young Investigator Award, International Society for Interferon and
Cytokine Research (ISICR)

2003-2007 National Cancer Institute Outstanding

Scholar Career Development Award

2006 ISICR Travel Award (declined due to government restrictions)

[Societies:]{.underline}

International Society for Interferon and Cytokine Research (ISICR),
membership committee member

International Society for Biological Therapy of Cancer (iSBTc)

[Scientific Activities:]{.underline}

Reviewer to the following journals:

Journal of Leukocyte Biology

Journal of Biological Chemistry

Clinical Cancer Research

Journal of Rheumatology

Immunity

Blood

Journal of Immunology

Sponsor/mentor:

2003-present The Werner H. Kirsten Student Intern Program (SIP)

[Research Interest:]{.underline}

Mechanisms of IFN-induced apoptosis

Antitumor properties of IFN-lambda

Identification of novel IFN inducible apoptotic genes

STAT single nucleotide polymorphisms

STATs and angiogenesis

[Present Address]{.underline}: 188 Greenway Drive

Frederick, MD 21702

[BIBLIOGRAPHY]{.underline}

1\. Gamero, A.M., Ussery, D., Reintgen, D.S., Puleo, C.A., and Djeu,
J.Y:. IL-15 induction of lymphokine-activated killer cell function
against autologous tumor cells in melanoma patient lymphocytes by a
CD18-dependent, perforin-related mechanism. [Cancer Res]{.underline}.
55:4988-4994, 1995.

2\. Santoni, G., Birarelli, P., Liu, J.H, Gamero, A., Djeu, J.Y., and
Piccoli, M.: An alpha 5 beta-1 like integrin receptor mediates the
binding of less pathogenic Candida Species to fibronectin. [J. Med.
Microbiol]{.underline}. 43:360-367, 1995.

3\. Wei, S., Liu, J.H., Epling-Burnette, P.K., Gamero, A.M., Ussery, D.,
Pearson, E.W., Elkabani, M.E., Diaz, J.I., and Djeu, J.Y.: Critical role
of lyn kinase in inhibition of neutrophil apoptosis by
granulocyte-macrophage colony-stimulating factor. [J.
Immunol]{.underline}. 157:5155-5162, 1996.

4\. Petricoin, E.F. III, Ito, S., Williams, B.L., Audet, S., Stancato,
L.F., Gamero, A., Clouse, K., Grimley, P., Weiss, A., Beeler, J.,
Finbloom, D.S., Shores, E.W., Abraham, R. and Larner, A.C.:
Antiproliferative actions of IFN-gamma require components of T cell
receptor signaling. [Nature]{.underline} 390:629-632, 1997

5\. Irby R., Mao, W., Coppola, D., Jove, R., Gamero, A., Cuthberston,
D., Fujita, D.J. and Yeatman, T.J.: Overexpression of normal c-Src in
poorly metastatic human colon cancer cells enhances primary tumor growth
but not metastatic potential. [Cell Growth Diff.]{.underline}
8:1287-1295, 1997.

6\. Barton, D.P.J., Cai, A., Wendt, K., Young, M., Gamero, A.,and
DeCesare, S.: Angiogenic protein expression in advanced epithelial
ovarian cancer. [Clin. Can. Res]{.underline}. 3:1579-1586. 1997.

7\. Wei, S., Gamero, A.M., Liu, J.H., Daulton, A.A., Valkov, N.I.,
Trapani, J.A., Larner, A.C., Weber, M.J., and Djeu, J.Y.: Control of
lytic function by mitogen activated protein kinase/ERK2 in a human
natural killer cell line: Identification of perforin and granzyme B
mobilization by functional ERK2. [J. Exp. Med]{.underline}.
187:1753-1765, 1998.

8\. Liu J.H.; Wei S; Burnette P.K.; Gamero A.M; Hutton M; Djeu J.Y.:
Functional association of TGF-beta receptor II with cyclin B.
[Oncogene]{.underline}:18:269-275, 1999.

9\. Gamero, A.M. and Larner, A.C.: Signaling via the T-cell antigen
receptor induces phosphorylation of stat1 on serine 727. [J. Biol.
Chem]{.underline}. 275:16574-16578, 2000.

10\. Gamero, A.M. and Larner, A.C.: Vanadate facilitates IFN-gamma
mediated apoptosis that is dependent on the Jak/Stat pathway. [J. Biol.
Chem]{.underline}. 276:13547-13553, 2001.

11\. Bauer, J.A., Morrison, B.H., Grane, R.W., Jacobs, B.S., Dabney, S,
Gamero, A.M., Carnevale, K.A., Smith, D.J., Drazba, J, Seetharam, B,
Lindner, D.J.: Effects of interferon beta on transcobalamin II-receptor
expression and antitumor activity of nitrosylcobalamin. [J. Natl. Cancer
Inst]{.underline}. 94:1010-1019, 2002.

12\. Navarro, A., Frevel, M., Gamero, A.M., Williams, B.R., Feldman, G.,
Larner, A.C.: Thrombomodulin RNA is destabilized through its
3\'-untranslated element in cells exposed to IFN-gamma. [J. Interferon
Cytokine Res]{.underline}. 23:723-728, 2003.

13\. Sakamoto, S., Qin, J., Navarro, A., Gamero A, Potla, R., Yi, T.,
Zhu, W., Baker, D.P., Feldman, G. and Larner, A.C.: Cells previously
desensitized to type 1 interferons display different mechanisms of
activation of stat-dependent gene expression than naive cells. [J. Biol.
Chem]{.underline}. 279:3245-53, 2004.

14\. Gamero, A.M., Sakamoto, S., Montenegro, J., and Larner, A.C.:
Identification of a novel conserved motif in the Stat family that is
required for tyrosine phosphorylation. [J. Biol. Chem]{.underline}.
279:12379-12385, 2004.

15\. Gamero, A.M., Young, H.A. and Wiltrout, R.H.: Inactivation of Stat3
in tumor cells: Releasing a brake on immune responses against cancer?
[Cancer Cell]{.underline} 5:111-112, 2004.

16\. Kim, H.P., Korn, L.L., Gamero, A.M., and Leonard, W.J.:
Calcium-dependent activation of interleukin-21 gene expression in T
cells. [J. Biol. Chem.]{.underline} 280:25291-25297, 2005.

17\. Gamero, A.M., Potla, R., Sakamoto, S., Baker, D.P., Abraham, R. and
Larner, A.C.: Type I Interferons Activate Apoptosis in a Jurkat Cell
Variant by Caspase-Dependent and Independent Mechanisms. [Cell.
Signaling]{.underline}. 18:1299-1308, 2006.

18\. Gamero, A.M. and Oppenheim J.J. IL-1 can act as number one.
[Immunity]{.underline} 24:16-17, 2006

19\. Gamero, A.M., Potla, R., Wegrzyn, J., Edling, A., Shimoda, K.,
Link, D.C., Dulak, J., Baker, D.P., Grayson, J.M., Tanabe, Y. and
Larner, A.C.: Activation of Tyk2 and Stat3 is required for the Apoptotic
Actions of IFN in Primary Pro-B cells. [J. Biol. Chem.]{.underline}
281:16238-16244, 2006.

20\. Gamero, A.M., Hodge, D.L., Reynolds, D.M., Rodriguez-Galan, M.C.,
Mohamadzadeh, M. and Young, H.A. Meager: Interferon-g: Gene and Protein
Structure, Transcription Regulation, and actions. The Interferon:
Characterization and Application. A Meager (Ed), Wiley-VCH Verlag GmbH &
Co., pp. 85-112, 2006.

21\. Kawasaki, B.T., Howard, O.M.Z, Gamero, A.M., and Farrar W.L.
Signalling by cytokines. The Cancer Handbook, John Wiley & Sons, Ltd.,
In press.

22\. Maher, S.G., Romero-Weaver, A.L., Scarzello, A.J., and Gamero, A.M.
Interferons: cellular executioner or white knight? [Current Medicinal
Chem]{.underline}., in press, 2007.

23\.

[SUBMITTED MANUSCRIPTS]{.underline}

1.  Maher, S.G., Sheikh, F., Scarzello, A.J., Romero-Weaver, A.L.,
    Baker, D.P., Donnelly, R.P., and Gamero, A.M. IFN-l is more potent
    than IFN-a in triggering apoptosis and maintaining STAT activation..
    [Submitted to Cellular Signaling, 3/07.]{.underline}

2\. Scarzello, A., Romero-Weaver, A.L., Maher, S.G., Veenstra, T.D.,
Zhou, M., Qin, A., and Gamero, A.M.: Induction of apoptosis by type I
IFN is promoted by a mutation in the SH2 domain of STAT2. [Will be
resubmitted to]{.underline} [Molecular Biology of the Cell,
8/2006.]{.underline}

.

[MANUSCRIPTS IN PREPARATION]{.underline}

1.  Romero-Weaver, A.L., Maher, S.G., Scarzello, A.J., and Gamero, A.M.:
    Development of type I interferon resistance implicates STAT2 as a
    critical mediator in the induction of apoptosis.