BEE-spoke-data/govdocs1-by-extension huggingface dataset:
ChileSPICE Version 1.8 Release Notes

March 15, 2002

The main improvements in ChileSPICE are in performance and stability of
the code. Specifically, these improvements are:

Improvements have been made on an existing capability that allows the
numerical integration package to temporarily increase the number of
newton iterations when the code is having difficulty converging. This
mostly relieves the user of having to increase iteration limits in order
to achieve convergence (which also can badly affect performance).

The Newton iteration convergence test has been improved to use a dynamic
value for the absolute voltage or current error that is allowed at a
particular node. The value used if 1.e-7 times a rolling average of the
absolute value seen at that node. This relieves the user of needing to
modify vntol and abstol to achieve convergence, and makes possible the
mixing of high and low voltage/currents in the same circuits.

The matrix factor and solve routines and the load routines have been
modified to allow a more efficient storage format for the matrix. This
is a packed column sparse format that significantly speeds up the
factorization/solve in many cases.

A few improvements in functionality are also present in version 1.8.
These are:

Added special variable \'time\' in expression evaluation package. allows
simulation time to be used in behavioral modelling expressions.

Improved naming of restart files such that enough digits are included in
the file name to uniquely identify it.

Improved error handling and reporting in the expression package such
that users can more readily identify expressions containing math errors
in behavioral expressions. In conjunction with this ChileSPICE no longer
puts in \'fixes\' for math errors such as using a \'huge\' value
(like1.e+50) when overflow is detected.

Added \'sdt()\' function into expression to give the value of the time
integral of the enclosed expression for behavior modelling.

Added noop flag to .tran line, if no operating point calculation is
desired.

Also, a \'QuickStart\' guide is included for new ChileSPICE users.
Experienced users may find some useful information in here as well!
**Statement of Work**

**Jonathan Rubin, Ph.D.**

**Dr. Rubin will conduct electrophysiological and neural modeling
experiments with Dr. Jeffrey Smith and other members of the Cellular and
Systems Neurobiology Section. These experiments will focus on
understanding oscillations in neural networks of the brain stem of
mammals related to the generation of respiratory movements. Dr. Rubin
will apply to this work his expertise in analyzing and modeling the
dynamics of small neural circuits with mathematical approaches, for
which he is considered a leading expert in the field of computational
neuroscience. **

**His primary responsibilities will be to: 1) assist with collection and
analysis of data from electrophysiological recording experiments; 2)
assist with data interpretation by model development; and, 3) assist
with the writing of manuscripts for peer-reviewed publication. **

**Request that a check in the amount of \$1,574.00 be issued to Dr.
Jonathan Rubin. The check will be used to cover lodging while he is here
at NIH. **

Checks will be mailed to the Project Officer:

Linda A. Franklin

10 Center Drive MSC 1426

Building 10, room 5N220

Bethesda, MD 20892

Period of Performance: 11/13/06-12/13/06
**Materials Not Included in**

**Airworthiness Directive (AD) Docket**

Docket Number: FAA- 2008-0554

Directorate Identifier: 2008NM100AD

747-53A2748 \-\-- 5/9/08

747-53-2253, R3 \-\-- 3/24/94

747-53-2272, R18 \-\-- 5/16/02

Name/Description of Item(s) Not Included in FDMS Docket and Maintained
in the

Supplemental AD Docket

**MAY BE VIEWED AT:** Federal Aviation Administration

Transport Airplane Directorate

Rules Docket

1601 Lind Ave. SW.,

Renton, WA 98057

425.227.1221

**DURING THE HOURS OF:** 9 a.m. and 3 p.m., Monday through Friday,

except Federal holidays.

Form Date: 03/05/2008
# New e-OG:P Print Function for Notices

**Effective January 1, 2008 the Patent and Trademark Office Notices have
been enhanced to include page numbers for each notice similar to the
numbering scheme in the discontinued paper product. In addition to
having page numbers, a print function has been added to allow users to
print an individual notice, rather than having to print the entire
week's notices. **

** A [Print Table of Contents]{.underline} feature will be present to
the left of the volume/page number in the header for the table of
contents to allow for printing of just the Table of Contents:**

** K OFFICE [Print Table of Contents]{.underline} 1326 OG 1 **

** A [Print This Notice]{.underline} feature will be present to the left
of the volume/page number in each header at the start each notice: **

** K OFFICE [Print This Notice]{.underline} 1326 OG 41 **

** A [Print Appendix]{.underline} feature will be present in the header
at the beginning of the appendix that includes the unnumbered pages
sections such as the PTO address listings, reference collection
listings, etc. **

** K OFFICE [Print Appendix]{.underline} 1326 **

**In each case, selecting the print function will generate a new window
with only the section you have chosen to print. To print that section,
you must then click on the Print this Notice button at the upper left
corner of the page:**

**Please address questions or comments to:**

**U.S. Patent and Trademark Office**\
**Office of Electronic Information Products**\
**MDW - 4C18**\
**P.O. Box 1450**\
**Alexandria, VA 22313-1450**\
**(571) 272-5600**\
**IPD@uspto.gov**
**Materials Not Included in**

**Airworthiness Directive (AD) Docket**

FAA-2007-0301

DMS Docket Number

2007NM069AD

Directorate (Old) Docket Number, If Any

747-53-2498 \-\-- 12/19/06

Name/Description of Item(s) Not Included in DMS Docket and Maintained in
the

Supplemental AD Docket

**MAY BE VIEWED AT:** Federal Aviation Administration

Transport Airplane Directorate

Rules Docket

1601 Lind Ave. SW.,

Renton, WA 98057

425.227.1221

**DURING THE HOURS OF:** 9 a.m. and 3 p.m., Monday through Friday,

except Federal holidays.
Computer Science

**ROLLING DICE IN A VIRTUAL 3D WORLD: NOT THE SAME THING, OR IS IT?,
**[Abram A Lenten]{.underline}, Jeff Horn\*, Northern Michigan
University - Marquette, Mathematics and Computer Science Department,
Marquette, MI 49855, ablenten@nmu.edu

The purpose of this project is to experiment with the behavior and
fidelity of a number of 3D physics engines through the use of virtual
dice. The project uses different physics systems to determine the best
length of a side for the design of fair n-sided dice. We then test the
best design by fabricating real world equivalent versions of these same
dice using a 3d printer for accuracy. Do these real world dice exhibit
similar or equivalent behaviors to that of their virtual counterparts?
[INSTRUCTIONS FOR USE OF OREGON CONSTRUCTION SPECIFICATION
(CS-42)]{.underline}

[CONCRETE FOR MINOR STRUCTURES]{.underline}

1\. [Applicability]{.underline}

Construction Specification CS-42 is applicable for minor concrete
structures. Minor structures include those of low hazard and cost where
strength control is not critical for the function or safety of the
structure.

2\. [Material Specifications]{.underline}

The NRCS material specifications complementary to OREGON State
Construction Specification CS-42 is MS-213, Steel Reinforcement and
MS-221, Preformed Expansion Joint Filler. The material requirements for
cement and aggregate are included in this construction specification.

3\. [Items to be Included in the Specifications and on the
Drawings]{.underline}:

a\. Details and cross-sections that are sufficient for describing the
structure are to be shown on the drawings.

b\. Specify reinforcing details including: size, grade, spacing and
splicing lengths and show on the drawings, if applicable.

c\. Specify type, size and quantity of joint filler, waterstops, shear
plates and other embedments and location show on the drawings, if
applicable.

d\. Specify the source of aggregates.

e\. Specify the concrete mix.

f\. Specify method of measurement and payment, if applicable.
**Brenda Olsen \<bolsen@lungfla.org\>**

  ---------------------
  09/30/2008 04:02 PM
  ---------------------

To

Group A-AND-R-DOCKET@EPA

cc

bcc

Subject

Attention Docket ID No. EPA-HQ-OAR- 2007-0562

+----+
|    |
+----+
|    |
+----+

Brenda Olsen, RN

Chief Operating Officer

American Lung Association of the Southeast, Inc.

539 Silver Slipper Lane, Ste A

Tallahassee, FL 32303

\(850\) 386-2065, ext. 3

\(850\) 422-1894 Fax

\(850\) 443-3017 Cell

Serving Florida, Georgia and South Carolina
**Materials Not Included in**

**Airworthiness Directive (AD) Docket**

Docket Number: FAA- 2008-0274

Directorate Identifier: 2008NM038AD

757-30-0019, R1 \-\-- 12/19/07

757-30-0019 \-\-- 7/19/06

757-30-0020, R1 \-\-- 12/19/07

757-30-0020 \-\-- 7/19/06

767-30-0039 \-\-- 12/5/07

767-30-0041 \-\-- 12/5/07

777-30-0012, R2 \-\-- 12/19/07

777-30-0012, R1 \-\-- 6/2/06

777-30-0012 \-\-- 4/15/04

Name/Description of Item(s) Not Included in FDMS Docket and Maintained
in the

Supplemental AD Docket

**MAY BE VIEWED AT:** Federal Aviation Administration

Transport Airplane Directorate

Rules Docket

1601 Lind Ave. SW.,

Renton, WA 98057

425.227.1221

**DURING THE HOURS OF:** 9 a.m. and 3 p.m., Monday through Friday,

except Federal holidays.

Form Date: 03/05/2008
**Roofers\', Waterproofers & Allied Workers Local No. 44**

**1651 East 24th Street**

**Cleveland, Ohio 44114-4211**

**216/781-4844 FAX 216/781-7663**

April 23, 2008

Kay H. Oshel

Dir. Office of Policy, Reports & Disclosure

Office of L/M Standards, U.S. DOL

200 Constitution Avenue N.W., Rm. N-5609

Washington, D.C.20210

Dear Director:

I am an officer and member of the Roofers Union Local 44 and a trustee
of the Roofers and Waterproofers Local 44 Pension and Welfare Funds. I
vigorously oppose the Form T-1 regulations. The goal of increasing
transparency is a poor excuse for the government's effort to impose
additional and costly burdens on the union and its small staff. Our
union's transactions are already transparent. Annually, our records are
independently audited by a certified public accountant. Detailed
disclosures are made to members at monthly meetings. Formal reporting is
made annually on our Form LM-2. The fringe benefit funds are also
audited annually. They file detailed Form 5500's. The pension fund
participants receive separate summary annual financial reports every
year.

This union is obliged to maintain the privacy of its members and
retirees. It would be a breach of union fiduciary duty to publicly
distribute a union membership list because it could be misused by mass
mailers, solicitors, criminals, spammers, etc. Yet, the Form T-1
regulations would compel this union to publicly identify its most
vulnerable class of members---the retirees---and to reveal the amount of
money that they receive each year from the pension fund.

This Local Union does not maintain information about fringe benefit fund
transactions as union records. The fringe benefit funds are separate
entities. Yet, the proposed T-1 regulations would oblige the union to
obtain substantial amounts of fringe benefit information and to release
all of it to the government (and public) on T-1 reports. The costs and
burdens are too high. These regulations should not be imposed.

We view the proposed FormT-1 regulations as another form of
union-busting.

The improperly motivated regulations must be revised to drop the
requirements of reporting information about transactions from the
separate fringe benefits funds.

Very truly yours

Robert W. Patton

Bus. Rep./ Trustee
September 30, 2004

#### [Docket ID: OPP-2004-0202]{.underline}

Docket Title: Pentachloronitrobenzene; Availability of Risk Assessment

#### [Subject:  PENTACHLORONITROBENZENE (PCNB): Revised Occupational and Residential Exposure Assessment for the Reregistration Eligibility Decision Document ]{.underline}

[Gustafson LLC specializes in seed treatment products and holds 70% of
the seed treatment market share. Gustafson LLC appreciates the
opportunity to comment on this document. ]{.underline}

A.  [Page 11 (Table 5)]{.underline}

    1.  [Cotton (commercial use) Switched the value in Column 3 and
        Column 4. The maximum cotton application rate for commercial use
        = 0.2526 lb.ai/100 lb seed]{.underline}

    2.  [Cotton (on-farm use) Maximum rate is 0.15 lb.ai/100 lbs seed
        instead of 0.015 lb.ai/100 lb seed. The rate of 0.15 lb.ai/100
        lbs is cited as the maximum rate for cotton (Table 10. "Seeding
        and PCNB application rates in pounds per acre for selected crops
        in the United States" from ]{.underline}*[Environmental Fate and
        Ecological Risk Assessment for the Re-registration of
        Pentachloronitrobenzene]{.underline}*[ PC Code
        056502)]{.underline}

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```
A.  [Page 20 (Table 6)]{.underline}

    1.  [Cotton (commercial use) The rate needs to be changed from
        0.000788 lb.ai/lb seed to 0.002526 lb.ai/lb seed (see A1). The
        adjusted factor is 3.2x (0.002526/0.000788).]{.underline}

    2.  [Cotton (on-farm use) The rate needs to be changed from 0.00015
        lb.ai/lb seed to 0.0015 lb.ai/lb seed (see A2). The adjusted
        factor is 10x (0.0015/0.00015).]{.underline}

```{=html}
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```
A.  [Page 23 (Table 8)]{.underline}

    1.  [MOE needs to be increased by 3.2x (see B1) for commercial
        cotton use. MOE needs to be increased by 10x (see B2) for
        on-farm cotton use. All the adjusted MOE values are still
        greater than 100. ]{.underline}

    2.  [Multiple activities: The MOE inhalation for barley, pea, rice,
        and soybean are less than 100. However, these MOEs are
        calculated based on the maximal treating capacity of 575,000 \~
        718,000 lb/day which only takes place in a large treating
        facility. Workers will have their own individual job functions
        rather than have multiple activities. ]{.underline}

```{=html}
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```
A.  [Pages 120-123 (Table B9, Appendix B)]{.underline}

    1.  [All the information pertaining to cotton needs to be revised
        reflecting the change of the maximum rate of 0.002526 lb.ai/lb
        (commercial) and 0.0015 lb.ai/lb seed (on-farm). The adjusted
        MOE values are still greater than 100.]{.underline}

[Sue-Chi Shen, Director]{.underline}

[Government and Regulatory Affairs]{.underline}

[Gustafson LLC]{.underline}

[1400 Preston Road, Suite 400]{.underline}

[Plano, TX 75025]{.underline}
[United States District Court]{.smallcaps}

for the

\<\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\> DISTRICT OF
\<\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\>

\<Name(s) of plaintiff(s)\>,

Plaintiff(s)

v\.

\<Name(s) of defendant(s)\>,

Defendant(s)

)

)

)

)

)

)

)

)

)

)

Civil Action No. \<Number\>

**MOTION TO DISMISS UNDER RULE 12(b)**

**FOR LACK OF JURISDICTION, IMPROPER VENUE, INSUFFICIENT**

**SERVICE OF PROCESS, OR FAILURE TO STATE A CLAIM**

The defendant moves to dismiss the action because:

1\. the amount in controversy is less than the sum or value specified by
28 U.S.C. § 1332;

2\. the defendant is not subject to the personal jurisdiction of this
court;

3\. venue is improper (this defendant does not reside in this district
and no part of the events or omissions giving rise to the claim occurred
in the district);

4\. the defendant has not been properly served, as shown by the attached
affidavits of \<\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\>; or

5\. the complaint fails to state a claim upon which relief can be
granted.

Date: \<Date\>

\<Signature of the attorney or unrepresented party\>

\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_

\<Printed name\>

\<Address\>

\<E-mail address\>

\<Telephone number\>
**SDDC OPERATIONS CENTER**

[ ]{.underline}**[CARRIER ADVISORY]{.underline}**

[ ]{.underline}**[July 20, 2007]{.underline}**

[ ]{.underline}**[CAR-07-07/20-0091]{.underline}**

**[[Subject:]{#OLE_LINK4}]{.underline}[[
]{#OLE_LINK4}]{.underline}**[Department Of Transportation (DOT) Pipeline
and Hazardous Materials Safety Administration Federal Register: July 16,
2007 (Volume 72 Number 135) 49 CFR Chapter I \[Docket No.
PHMSA--2007--27329 (HM--233A)\] RIN 2137--AD84 Hazardous Materials:
Conversion of Special Permits into Regulations of General Applicability
Agency: Pipeline and Hazardous Materials Safety Administration (PHMSA)
Issues: Petitions for Rulemaking. ]{.underline}

**[Purpose:]{.underline}**[ This notice advises DOD interested persons
that PHMSA, DOT is requesting comments on proposed rulemaking regarding
Hazardous Materials Regulations (HMR); 49 CFR Chapter I, on conversion
of Special Permits. ]{.underline}

**[Be Advised: ]{.underline}[ ]{.underline}**[PHMSA is in the process of
reviewing widely-used special permits to identify those that have proven
safety records and should be converted into the Hazardous Materials
Regulations (HMR) as regulations of general applicability. A special
permit is an authorization issued by PHMSA that allows a company or
individual to package or ship a hazardous material in a manner that
varies from the regulations provided an equivalent level of safety is
maintained or that, in an emergency, is necessary to protect life or
property. Incorporation of special permits into the HMR is a regulatory
reform effort. ]{.underline}

**[D]{.underline}[ate]{.underline}[:]{.underline}**[ To meet PHMSA,
DOT's deadline, comments should be submitted to your respective service
Headquarters' (HQ) representative who will consolidate the responses and
submit to SDDC, POC below on or prior to 31 August 2007. ]{.underline}

**[Address]{.underline}[: ]{.underline}[ ]{.underline}**[You may view
the docket to read background information at , click open dockets and
look for agency's name PHMSA, Hazardous Materials: Incorporation of
Special Permits Into Regulation, US DOT/PHMSA-Request for Comments,
PHMSA-2007-27329, 2137-AD84, 16-Jul-2007, 14-Sep-2007, 72 FR 38810.
]{.underline}

**[PHMSA POC:]{.underline}**[ For further comment information contact
DOT Office, Eileen Edmonson, Office of Hazardous Materials Standards,
(202) 366--8553, or Diane LaValle, Office of Hazardous Materials Special
Permits and Approvals, (202) 366--4535, Pipeline and Hazardous Materials
Safety Administration (PHMSA), or by e-mail to: Eileen.Edmonson@dot.gov,
or Diane.LaValle@dot.gov.Item ]{.underline}

**[SDDC ]{.underline}[POC:]{.underline}**[ [M]{#OLE_LINK5}[s. Michele
Florence]{#OLE_LINK5}[ at 757-878-8]{#OLE_LINK5}[269]{#OLE_LINK5}[, DSN:
826-8]{#OLE_LINK5}[269 or ]{#OLE_LINK5}[via email:
nnvhazmat@sddc.army.mil.]{#OLE_LINK5}]{.underline}

**[Expiration:]{.underline}**[ 31 August 2007]{.underline}
**Materials Not Included in**

**Airworthiness Directive (AD) Docket**

FAA-2007-0390

DMS Docket Number

2007NM260AD

Directorate (Old) Docket Number, If Any

A320-53-1195, R02 \-\-- 4/5/07

A320-53-1195, R01 \-\-- 11/29/06

A320-53-1195 \-\-- 6/23/06

A320-53-1196, R01 \-\-- 11/29/06

A320-53-1196 \-\-- 6/23/06

Name/Description of Item(s) Not Included in DMS Docket and Maintained in
the

Supplemental AD Docket

**MAY BE VIEWED AT:** Federal Aviation Administration

Transport Airplane Directorate

Rules Docket

1601 Lind Ave. SW.,

Renton, WA 98057

425.227.1221

**DURING THE HOURS OF:** 9 a.m. and 3 p.m., Monday through Friday,

except Federal holidays.
**Questions for the July 19, 2000 **

Psychopharmacological Drugs Advisory Committee

##### Holiday Inn, 8120 Wisconsin Avenue, Bethesda, Maryland

**NDA 20-825: Zeldox(ziprasidone hydrochloride capsules, Pfizer) **

**A. Issues to be considered:**

# Principles Considered in Regulating QTc Prolonging Drugs

-Indication/Available Treatments

-Observed QTc Effect

-Other evidence suggestive of a serious outcome associated with a drug's
QTc effect

-Metabolic Problem

Indication/Available Treatments

-How serious is it?

-How effective are available treatments?

-How many alternative treatments are available?

-How does new treatment compare regarding efficacy?

-How does new treatment compare regarding safety?

Observed QTc Effect

-Absolute size of mean QTc effect in dose range proposed?

-Proportion of outliers on QTc effect?

-having a change from baseline of 75 msec

-going over some threshhold, such as 500 msec

Other Evidence Suggestive of a Serious Outcome Associated with a Drug's
QTc Effect

-Excess overall mortality or SUDs

-NDA database

-Other experience

-Actual cases of TDP or other serious arrhythmia

-Excess syncopal episodes

Metabolic Problem

-Vulnerability to increased plasma levels

-In presence of inhibitor

-In subpopulation with compromised metabolic capacity (e.g., 2D6 poor
metabolizers)

## B: General Questions for Committee

1\. Has the sponsor provided evidence from more than one adequate and
well-controlled clinical investigation that supports the conclusion that
ziprasidone is effective for the treatment of schizophrenia?

2\. Has the sponsor provided evidence that ziprasidone is safe when used
in the treatment of schizophrenia?

If the committee responds positively to the 2 general questions, there
are some additional questions and issues that we would like you to
consider in your discussions.

3\. Do you think that ziprasidone's risk of serious ventricular
arrhythmias and SUD is greater than that of most other drugs in this
class (even if that excess risk cannot be quantified)?

4\. If you believe there is some excess risk, albeit unquantified, of
serious ventricular arrhythmias and SUD associated with the use of
ziprasidone, and you, nevertheless, conclude that ziprasidone should be
approved, how should this excess risk be managed in labeling?

-First line vs second line status?

-What prominence should the risk be given in labeling?

-Black box warning

-Lesser warning statement

-Should there be a medication guide for patients to alert them to the
risks of using ziprasidone?

5\. Should the sponsor be required to conduct additional studies for
ziprasidone, and when should these studies be conducted relative to any
approval decisions regarding this application?

-Large comparative trial to estimate (or rule out at some level) the
risk of excess SUD in association with the use of ziprasidone

-Study to demonstrate superior efficacy for ziprasidone, e.g., in
patients demonstrated to be refractory to standard therapy
CHANGE ORDER ACCOUNTING (52.243‑6) (APR 1984)

    The Contracting Officer may require change order accounting whenever the estimated cost of a change or series of related changes exceeds $100,000.  The Contractor, for each change or series of related changes, shall maintain separate accounts, by job order or other suitable accounting procedure, of all incurred segregable, direct costs (less allocable credits) of work, both changed and not changed, allocable to the change.  The Contractor shall maintain such accounts until the parties agree to an equitable adjustment for the changes ordered by the Contracting Officer or the matter is conclusively disposed of in accordance with the Disputes clause.

    (End of clause)
--
  --

    Dear Administrator Johnson

    Please make this Guidance protect all of our nation's waters, not just some of them. 

    Protection of water bodies should be done by type of water and its geography, and should not force a more narrow case by case consideration which will result in lots of important small streams and wetlands losing protections. 

    Our policies should take into account all the benefits of this kind of protection and all the threats to water quality and quantity.

    Weakening the intent of the Clean Water Act puts my family's drinking water at risk.  It endangers our lakes, rivers and streams for use in outdoor recreation and for the sustainability of the ecosystem as a whole.  I urge you to take this seriously.

    Stephanie Hyer

    11321 N. 50th St. Apt. 17

    Tampa, FL 33605
***Probe generation by nick-translation***

#### Equipment and reagents)

· E. coli DNA polymerase I, nick translation grade (Roche Molecular
Biochemicals)

· 10 mM biotin-16 dUTP (Roche Molecular Biochemicals)

· 10 mM dNTPs set (Roche Molecular Biochemicals)

· b-mercaptoethanol (Sigma)

· Bovine serum albumine (BSA) (Sigma)

· Pre-chilled (-20ºC) absolute ethanol

· Nuclease-free water

· 10 x nick translation buffer: Add 500 ml 1M Tris-HCl (pH 8.0) and 100
ml 0.5 M MgCl~2~ and 5 ml BSA (0.5 mg/ml) into 1.5 ml test tube. Add 395
ml water to adjust the reaction volume into 1ml

· Nucleotide stock. To a 1.5 ml test tube add 10 ml 10 mM dATP, 10 ml 10
mM dCTP, 10 ml 10 mM dGTP, 10 ml 10 mM biotin-16-dUTP and 4 ml 1 M
Tris-HCl (pH 7.4). Add 156 ml nuclease-free water to adjust the reaction
volume to 200 ml

· 0.1M b-mercaptoethanol. Into a 1.5 ml test tube add 0.7 ml
b-mercaptoethanol Add 999.3 ml sterile water to adjust the final volume
to 1 ml

· Dnase I, RNase-free (10 units, ml) (Roche Molecular Biochemicals: Make
a stock solution of 10 mg/ml DNase I in 50 % (v/v) glycerol which can be
stored at --20ºC. Add 1 ml DNase I stock solution into 9 ml ice-cold
water to make a stock solution (1mg/ml). Add 1 ml DNase I (1 mg/ml)
stock solution in 100 ml ice-cold water immediately before use; discard
afterwards

#### Method

1\. Add into a 1.5 ml test tube on ice 10 ml 10 x nick translation
buffer, 10 ml nucleotide stock, 10 ml b-mercaptoethanol, 2 mg probe DNA,
1 ml DNase I (100 mg/ml), 1 ml DNA polymerase I (10 U/ml). Add 66 ml
nuclease-free water to adjust the final reaction volume to 100 ml^a^

2\. Centrifuge the test tube briefly at 4ºC

3\. Immediately place the test tube into a 16ºC waterbath. Incubate for
2 h

4\. Put the test tube on ice immediately. Take 5 ml of sample from the
test tube, add agarose gel loading buffer, denature for 3 min at 95ºC,
and run on 1% agarose gel^b^.

5\. To separate the probe from unincorporated nucleotides by ethanol
precipititation add 1 ml 0.1 M EDTA to stop the reaction and add 10 ml 3
M sodium acetate (pH 5.2) and 200 ml of pre-chilled (-20ºC) absolute
ethanol

6\. Let the precipitate form for at least 20 min at --20ºC

7\. Centrifuge the tube at 13,000 x g for 15 min at 4ºC. Very carefully
discard the supernatant

8\. Dry the pellet under vacuum. Take care not to over dry the sample

9\. Resuspend the DNA in 20 ml nuclease-free water for a final
concentration of \~ 100 ng/ml.

10\. Store at --20ºC

^a^The appropriate dilution of DNase I is critical in controlling the
size of the labeled probe

^b^The probe should run as a smear between 100-300 bps in size. If the
probe is not the correct size, return the test tube to the 16ºC
waterbath for further digestion. If the probe is less than 100 nt in
size use less DNAse I or shorter incubation periods.
Jury deliberates for second day in lead paint case

**Friday, October 25, 2002 Posted: 2:06 PM EDT (1806 GMT)**

**PROVIDENCE, Rhode Island (AP) \--** **The state\'s landmark lawsuit
against the lead paint industry is now in the hands of a jury that must
decide if the product creates a public health threat.**

Jurors returned to court Friday for their second day of deliberations.
They were wrestling with the sole question on their verdict sheet:
\"Does the presence of lead pigment in paint and in coats in homes,
schools, hospitals and other public and private buildings throughout the
state of Rhode Island constitute a public nuisance?\"

Before giving them the case Thursday, Superior Court Judge Michael
Silverstein told the six-person jury they were not to consider whether
the paint industry is liable for poisoning children, nor to assess
damages. Those issues will be determined in later trials if the state
prevails in this lawsuit, the judge said.

Silverstein defined a public nuisance as something that interferes with
the public\'s well-being to an unreasonable degree.

\"The essential claim is that someone has suffered harm or injuries they
ought not have to bear,\" Silverstein said.

Lead paint was banned in 1978, after studies showed flaking paint or
dust is harmful to children who eat or breathe it. Health problems
include behavioral disorders, brain damage and even death.

Rhode Island is the first state to try to hold the industry accountable
for poisoning children. Attorney General Sheldon Whitehouse\'s lawsuit
names eight former lead paint manufacturers.

The state claims the paint is a public health threat, arguing it has
poisoned 35,000 children in Rhode Island since 1993. Attorneys say the
paint is dangerous regardless of its condition.

The paint companies contend the problem is isolated to deteriorating
paint found in homes managed by delinquent landlords or irresponsible
homeowners.

If the state prevails, a new jury would decide if paint companies can be
held liable. A subsequent phase could involve damages.

2\.

Legal analysts say a verdict for the state in this phase would invite
other states and communities to file lawsuits of their own.

More than 40 lawsuits have been filed since 1989 by individuals and
communities against lead paint companies. All have failed. Rhode Island
is the first state to sue the industry under public nuisance law.

The companies named in the lawsuit are American Cyanamid Co.; Atlantic
Richfield; ConAgra Grocery Products Co.; Cytec Industries Inc.; DuPont
Co.; Millennium Inorganic Chemicals, Inc.; NL Industries Inc.; and
Sherwin-Williams Co.
**BD Stillion \<meadow_by_the_marsh@yahoo.com\>**

Sent by: American Rivers \<info@americanrivers.org\>

04/02/2008 05:42 PM

Please respond to

BD Stillion \<meadow_by_the_marsh@yahoo.com\>

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To

OW-Docket@EPA

cc

bcc

Subject

EPA-R04-OW-2008-0179

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    Apr 2, 2008

    Mr.  Stephen Johnson

    1200 Pennsylvania Avenue, NW

    Washington, DC 20460

    Dear Mr.  Johnson,

    As Christians, we are charged to be good STEWARDS of all of God's

    creation.  It is not for us to exploit any living thing out of greed

    or pride, or for us to decide that any living thing has no good

    purpose and thus can be callously done away with.

    The parables of Jesus are full of examples of what happens when a

    steward does not take careful heed to what becomes of the Master's

    property.  We will be held accountable for how we use, protect, or

    abuse God's creation.

    Mahatma Gandhi taught that one could know the quality of a society by

    how that society treats animals.  Our Christian heritage teaches that

    we are stewards of all God's creation, not owners to dispose of it

    where we see fit.  The parables of Jesus are full of great insight

    regarding what happens when a steward, left in charge of caring for

    the true owner's property, fails in that charge.  Let us be good and

    faithful servants, and show the truly excellent quality of our society

    and ourselves.  Let us care for all living things with utmost regard

    for the sanctity of life.

    I applaud your agency's initiation of a Clean Water Act veto for the

    Yazoo Backwater Pumping Plant project (Yazoo Pumps) in Mississippi,

    and urge you to finalize that veto as quickly as possible.

    Sincerely,

    Dr. BD Stillion

    135 County Road 751

    Jonesboro, AR 72401-2196
**[Statement of Work]{.underline}**

**Yuan-Chii Lee (Gladys), Ph.D.**

**Taipei Medical University**

**Taipei, Taiwan**

Dr. Lee is coming to NIH to work with Dr. Yang Fann, Ph.D., on
collaborative research projects in bioinformatics including microarray
experiments and data analysis. Complete the microarray data analysis of
spinal cord injury and prepare manuscript for publication.

Dr. Fann has agreed to provide airfare for Dr. Lee. It is requested that
the contractor provide the project officer with a check in the amount of
\$2,000 made payable to Dr. Lee to reimburse her airfare.

The period of performance is June 29, 2008 to August 1, 2008.

The check should be sent to the project officer upon request to the
following:

Linda A. Franklin

NIH/NINDS/AO

10 Center Drive, Room 5N220

Bldg.10/5N220 MSC1426

Bethesda, MD 20892-1426
**National Steering Committee for the **

**Reauthorization of the**

**Indian Health Care Improvement Act, P.L. 94-437**

**DRAFT 1 of a Proposed Reauthorized Bill**

**July 16, 1999**

**For Review and Comment Only**

**[Written Comments and Edits Are Welcome!]{.smallcaps}**

**[Please submit Written Comments NO LATER THAN August 16, 1999
to:]{.smallcaps}**

**Kauffman & Associates -- P. O. Box 1401, Kamiah, ID 83536**

**Phone: (208) 935-0665 -- Fax: (208:935-0354 -- Email:
Kauffman@camasnet.com**
**Washingtonpost.com**

**METRO In Brief**

\
**Staff writers Vanessa Williams, Avram Goldstein, Patrice Gaines,
Jackie Spinner, Katherine Shaver, Phuong Ly, Emily Wax, Martin Weil and
Ann O\'Hanlon contributed to this report**

**Sunday, October 3, 1999; Page C03 **

**THE DISTRICT **

**Decision Due on Commerce Reopening **

Commerce Department officials expect to announce today when they will
reopen the agency\'s headquarters, which had to be evacuated Friday
after an electrical transformer exploded and released a cancer-causing
liquid.

Morrie Goodman, Commerce public affairs director, said yesterday that
the agency was awaiting test results.

The explosion and fire were confined to the basement of the 1.6
million-square-foot building on 14th Street NW. After some employees
became ill, firefighters learned the transformer contained
polychlorinated biphenyls, or PCBs. Forty-eight people, including 10
firefighters, were taken to George Washington University Hospital for
decontamination. Most were released Friday; the last few were discharged
yesterday.

A recording on the Commerce information number said the building would
be closed through the weekend. It said employees should \"anticipate\"
returning to work tomorrow and advised calling back for updates. The
number is 202-482-2000.

© Copyright 1999 The Washington Post Company
Michael Finneran\
**For release:** February 24, 199\
(804) 864-8150\
RELEASE NO. 95-12

***LANGLEY TECH TRANSFER WILL HELP FIRMS IMPROVE PRODUCT DESIGN***

A Los Angeles-based firm has signed an agreement with Langley Research
Center to use NASA-developed technology that will help industries
worldwide speed up and improve the design of a wide range of products,
from cars to coffeemakers.

Langley signed the cooperative agreement with The MacNeal-Schwendler
Corp. (MSC), a world leader in computer software for simulating the
performance of structural and mechanical systems.

Under the 3-year agreement, MacNeal-Schwendler will receive Langley
developed technology for modeling structural systems. The company plans
to program that capability and incorporate it into its most popular
product, a structural analysis computer program called MSC/NASTRAN. With
this new capability, MacNeal-Schwendler customers will be able to create
computer models easier and faster, and their computer simulations will
be more accurate.

Many industries design products by simulating their performance on a
computer before building costly prototype models.

\"For example, during the design of a new car, a computer model of the
vehicle could be crashed into a computer model of a barrier, and the
results studied to see if passengers in a real automobile would have
been injured,\" said Dr. W. Jefferson Stroud, of Langley's Computational
Structures Branch, Structures Division, which is where the technology
was developed. \"The designer could use that information, together with
results from many other computer simulations, to arrive at a design that
meets cost and performance targets\"

\"This is a good marriage between technology and what both NASA and MSC
want to get out of the project,\"Stroud added. \"We'll be able to move
this important technological development into the general mainstream of
design engineering.\"

The type of software sold by MacNeal-Schwendler is used by industries
around the world, including shipbuilders, automakers, aerospace firms,
consumer-products companies, and many more. The transfer of technology
to non-aerospace companies is part of a new effort at Langley to help
develop U.S. competitiveness in a global market.

**- end -**
Conference, Administrative & Travel Services (CATS)

Statement of Work -- Donna Teresa Giraldez FERNANDEZ, Ph.D.

Dr. Fernandez will travel from Spain to the U.S. November 17, 2007 and
stay until December 5, 2007 to collaborate with Dr. Miguel Holmgren's
NINDS/MNU Lab. She will teach members of the MNU Lab a new Patch
Fluorometry Method. In order to do so, she will be required to interact
and perform several experiments with the Lab members in Building 35-3B.

Dr. Holmgren has agreed to provide airfare and perdiem for Dr.
Fernandez's visit.

Perdiem: \$ 1,185.00

Airfare: 1,018.00

TOTAL \$ 2,203.00

Request (one) check for the perdiem and airfare in the amount of
\$2,203.00

for Dr. Fernandez.

Check will be requested by and mailed to the Project Officer below:

Linda A. Franklin

Building 10, Room 5N220

10 Center Drive MSC 1426

Bethesda, MD 20892-1426.
February 15, 2007

Mr. Drew Dawson, EMS Director

National Highway Safety Administration

Washington, D.C.

Dear Sir:

[I am very much interested in becoming a member of the National
Emergency Medical Services Advisory Council. I am a twenty year member
of my local all volunteer fire department and have served as a member of
the Board of Trustees. I have been an emergency medical technician for
twenty-one years, an instructor for nineteen years, and have served as
president of our local EMS Instructor's Association. For fifteen years I
volunteered with Soldiers and Sailors Hospital Advanced Life Support
program as an EMT. For the past ten years I have served as president of
the Tioga County EMS Council and currently serve as the president of the
Lycoming, Tioga, Sullivan Regional EMS Council. ]{.underline}

[I represent Tioga County to the Pennsylvania Emergency Health Services
Council and currently serve on the Board of Directors. In this capacity
I serve on a committee charged with review and revision of the Basic
Life Support Skill sheets and Practical Test Scenarios for
Pennsylvania.]{.underline}

[I am also a member of the Northern Central Tier Counter Terrorism Task
Force Health and Medical Committee.]{.underline}

[I feel that my knowledge and experience particularly in the areas of
EMS education, emergency management, hospital based EMS, and the state
and county legislative bodies as well as as an active volunteer provider
in the provision of emergency medical services could be of assistance in
NEMSACs stated goals of improved assessment, plan development,
coordination, and oversight at the federal level. Because of the variety
of positions I have held I appreciate the importance of participating in
good faith so that each organization receives benefit of the best I can
provide independent of other groups. Should I be appointed to NEMSAC I
will participate in a like manner to the best of my ability.
]{.underline}

[I look forward to hearing from you. I can be reached at , by phone at
570-376-2143, or by mail at 318 North Road, Middlebury Center, PA
16935.]{.underline}

[Sincerely,]{.underline}

[John L. Getty]{.underline}
--
  --

    Dear EPA:

    Louisiana's habitat has suffered enough!  While I live in New York, I spend a great deal of time in Louisiana and enjoy every minute of it.  I bring many outdoor writers and customers to the area to enjoy the wildlife and fishing.

    I am writing to voice my support of EPA's initiation of a veto of the Yazoo Pumps Project under section 404(c) of the Clean Water Act. The Yazoo Pumps would result in an unacceptable amount of wetland loss in the state of Mississippi and waste at least $211 million federal tax dollars. 

    In 2000, the Environmental Protection Agency (EPA) concluded that the Yazoo Pumps would drain and damage more than 200,000 acres of ecologically significant wetlands.  The wetlands that will be drained are among the richest natural resources in the nation, and are along a critical migration route for 20 percent of the nation's duck population.  

    In summary, the Yazoo Pumps project would cause significant degradation of the aquatic environment, including impacts to fish and wildlife.  I urge EPA to finalize a veto of this project under section 404(c) of the Clean Water Act.

    Sincerely,

     Jeff Pierce

    8 Church Street

    Scottsville, NY 14546
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| **\"Melvin Van denTop\" \<vdmd1@qwestoffice.net\>** |
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**RE: Renewable Fuels Standard (RFS) Waiver Request.**

This ethanol production boondoggle is a failure. Although it DOES
demonstrate the technological ability of the human being, it does so on
such a primitive scale that it is unworthy of the praise and
glorification given to it by jump-on-the-bandwagon (e.i. bandwagon)
politicians and a baffled, non-scientifically minded population unless
one were to relegate the results to the intellectual capacities of\--say
a high school science project accomplishment\--and be willing to live
within the stunted, genocidal, population decimating confines it
demands. This is simply unworthy of consideration for the future of
mankind! Stop this foolishness. At projected population growth rates,
this planet will have 9 billion people by 2050 from the current 6.5
billion! What regard for human potentiality is represented by taking
food and/or arable land food-production capacity and converting it to
fuel to be burned in internal combustion engines? Where is the shame in
even CONSIDERING such a policy? How many who sit in church praying each
Sunday are participating in this crime?

No, let\'s instead KILL the British Empire style \"free-market\"
globalization\--remember colonization?\--system NOW by refusing to be
sold into such a genocidal slavery and deny the financial speculators
(contrasted with investors in viable public projects) of their power to
loot the populations of the planet while killing them off. So called
\"market economics\" without regard for the sanctity of human life is a
crime against humanity! DOUBLING food production for the projected
population growth is a goal worthy of government OF THE PEOPLE and must
replace this arrogant, human-being hating policy!
**roy.wood@kodak.com**

  ---------------------
  02/02/2009 09:59 AM
  ---------------------

To

Group A-AND-R-DOCKET@EPA

cc

bcc

Subject

Kodak CPMS comments, Docket ID No. EPA-HQ-OAR-2006-0640

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Attached are Kodak\'s CPMS comments for Docket ID No.
EPA-HQ-OAR-2006-0640. These comments are in response to:

Performance Specification and Quality Assurance Requirements for
Continuous Parameter Monitoring Systems and Amendments to Standards of
Performance for New Stationary Sources: National Emissions Standards for
Hazardous Air Pollutants; and National Emissions Standards for Hazardous
Air Pollutants for Source Categories, Proposed Rule, 73FR59956-60008,
October 9, 2008.

Thanks,

**Roy W. Wood**

HSE US ROCHESTER HSE SERVICES

Eastman Kodak Company

1669 Lake Ave

Rochester, NY 14652-4543

[roy.wood@kodak.com]{.underline}

Office: 585 588-7538

Fax: 585-722-2216

[www.kodak.com]{.underline}
**Materials Not Included in**

**Airworthiness Directive (AD) Docket**

Docket Number: FAA- 2008-0293

Directorate Identifier: 2007NM287AD

ATR42-30-0072, R1 \-\-- 6/1/05

ATR42-30-0074 \-\-- 5/14/07

ATR42-30-0074, R01 \-\-- 9/26/07

ATR72-30-1042, R1 \-\-- 6/1/05

ATR72-30-1044 \-\-- 5/14/07

ATR72-30-1044, R01 \-\-- 9/16/07

Name/Description of Item(s) Not Included in FDMS Docket and Maintained
in the

Supplemental AD Docket

**MAY BE VIEWED AT:** Federal Aviation Administration

Transport Airplane Directorate

Rules Docket

1601 Lind Ave. SW.,

Renton, WA 98057

425.227.1221

**DURING THE HOURS OF:** 9 a.m. and 3 p.m., Monday through Friday,

except Federal holidays.

Form Date: 03/05/2008
John W. Taylor, Jr.

    IPM Specialist

    Forest Health Protection

    State and Private Forestry

    Southern Region

    Suite 862 S

    1720 Peachtree St, NW

    Atlanta, GA 30309

    404-347-2718-office

    404-909-0270-cell

    404-347-1880-fax

    jwtaylor@fs.fed.us

    We have some concerns with the EPA's proposed label 

    changes for the Sevin XLR label, particularly the "bee caution" portion. 

    Our concern is that if the label on the XLR product is changed to the same 

    wording used on the other carbaryl labels, as  EPA intends to, all 

    forestry uses, including poplar/cottonwood plantation treatments in the 

    Midwest and bark beetle treatments in the Western US, will be excluded 

    since the wording will prohibit applications when "bees are visiting the 

    treatment area", as opposed to "foraging in the treatment areas" as on the 

    current XLR label, at any time weeds are flowering. The term "visiting" is 

    so general that I would not be comfortable recommending Sevin XLR for use 

    on any forestry sites since technically the applicator could be in 

    violation if bees (of any genera or species, not just the honeybee) could 

    be found on the treatment site when flowers are present (which could be 

    virtually any season in parts of the South and West). Since carbaryl is 

    the only product presently labeled and efficacious for bark beetles on 

    forest sites in the western US,  and is the primary control for Cottonwood 

    Leaf Beetle in poplar/cottonwood plantations in the South and Midwest, we 

    are very concerned about this change. Implementation of the proposed 

    wording will essentially, in my opinion at least, remove Sevin XLR as a 

    tool for managing forest insect pests when any blooming plant is present 

    on the treatment site.
**Materials Not Included in**

**Airworthiness Directive (AD) Docket**

Docket Number: FAA- 2007-29331

Directorate Identifier: 2007NM136AD

340-32-133 \-\-- 4/19/06

APPH AIR83022-32-32, R2 \-\-- 3/30/06

APPH AIR83022-32-32, R1 \-\-- 1/23/06

APPH AIR83022-32-32 \-\-- 1/06

APPH AIR83064-32-12, R2 \-\-- 3/30/06

APPH AIR83064-32-12, R1 \-\-- 1/23/06

APPH AIR83064-32-12 \-\-- 1/06

Name/Description of Item(s) Not Included in FDMS Docket and Maintained
in the

Supplemental AD Docket

**MAY BE VIEWED AT:** Federal Aviation Administration

Transport Airplane Directorate

Rules Docket

1601 Lind Ave. SW.,

Renton, WA 98057

425.227.1221

**DURING THE HOURS OF:** 9 a.m. and 3 p.m., Monday through Friday,

except Federal holidays.

Form Date: 03/05/2008