**STATENIENT OF WORK**

**Helgi Valdimarsson**

**BACKGROUND INFORMATION **

Dr. Helgi Valdimarsson is presently a Professor of lmmunology at the
Department of Immunology, Institute for Medical Laboratory Sciences,
Lanspitali, University Hospital,in Reykjavik, Iceland. The Laboratory of
Host Defenses, DIR, NIAID is an organization that recognizes the need to
plan, implement, and maintain an active program of research to promote
the mission of the NIAID. The mission of the Mucosal Immunity Section in
particular is to conduct a broad spectrum of studies on the immune
system of mucosal surfaces. Current studies focus on experimental models
of ulcerative colitis and the mechanisms underlying ulcerative colitis.
These studies involve a wide range of molecular biology and biochemical
techniques. The Laboratory is well equipped with cell purification,
culturing, imaging, and other technologies necessary to carry out such
experiments. The members of the Laboratory are interactive and hold
weekly seminars and journal clubs to facilitate the design and analysis
of experiments.

**PURPOSES AND OBJECTIVES OF THE ACQUISITION **

The purpose of this procurement is to allow Dr. Valdimarsson to study
immunoregulatory mechanisms in the gut and skin. Studies he has begun in
his laboratory in Iceland will be central to the collaboration of the
laboratory headed by Dr. Warren Strober. The period of performance is
from May 2, 2008 through May 31, 2008.

**CONTRACTOR REQUIREMENTS **

In particular, Dr. Valdimarsson will be examining thymuses extracted
from mice specially bred for the purpose here at the NIH. Techniques
developed in the Mucosal Immunity Section will be adapted and improved.
During this work, Dr. Valdimarsson will maintain complete records so as
to provide a basis~\ ~for subsequent publication in peer-reviewed
journals.

**CONTRACTOR SUPPLIED MATERIAIS **

The contractor shall provide his own laptop, writing instruments, and
notebooks.

**GOVERNMENT RESPONSIBILITIES **

The Mucosal Immunity Section, LHD, DIR, NIAID stipulates that we will
provide Dr. Valdimarsson with access to the laboratory equipment and
computers that are required to complete Dr. Valdimarsson\'s experiments
and to write up a manuscript. This includes access to telephones, fax
machines, printers, copiers, and office supplies. Work products
(experimental results) and manuscripts will be submitted to Dr. Strober
of the MIS,LHD,DIR, NIAID for final review and approval. Work products
will be monitored daily and weekly by the Head of the Mucosal Immunity
Section, who is Dr. Warren Strober.

**REPORTING REQUIREMENTS AND DELIVERABLES **

Work products will be monitored daily and weekly by the Head of the
Mucosal Immunity

Section, who is Dr. Warren Strober.

**PROGRAM MANAGEMENT AND CONTROL REQUIREMENTS **

Dr. Warren Strober will assure that tasks are completed under the terms
of this contract. The

final work product that is, the manuscript will be submitted to the Head
of the Mucosal

Immunity Section for approval.

**INSPECTION AND ACCEPTANCE **

a\) Work products described above will be reviewed and approved on-site
by Dr. Warren

Strober, the laboratory supervisor, in the Mucosal Immunity Section,
LHD, DIR, NIAID.

b\) All work will be completed in accordance with professional
standards.

**ATTACHMENTS **

None

**JUSTIFICATION OF NEED **

The MIS,LHD,DIR,NIAID requires specific knowledge and experience in the
evaluation of the effects that the thymus stromal lymphopoietin may have
on human alpha24 and NKT cells. In particular, cell purification,
culturing, and analysis is required. A thorough familiarity with these
techniques is required to successfully complete the experiments needed
to determine the functional relevance of these proteases.

**SOLE SOURCE PROCUREMENT **

Dr. Valdimarsson has several years of experience as a scientist in a
leading Icelandic laboratory that focuses on autoimmune disorders. He is
familiar with the methods of cell culturing and cell purification. Dr.
Valdimarsson is well-qualified to carry out the experimental work that
is required here to evaluate the effects that the thymus stromal
lymphopoietin may have on human aloha24 and NKT cells.

**TASK DESCRIPTION**

Firm will issue 2 checks on the following payment days for the following
amounts:

16 May 2008 \$5,175.

31 May 2008 \$3,975.

Checks will be issued to Dr. Helgi Valdimarsson. The checks should be
sent via express mail to the NIAID, to the attention of Martha Canning
at the following address:

Mailing Address:

Martha Canning, Administrative Officer

Building 10, Room 11C440

10 Center Drive, MSC 1878

Bethesda, MD 20892