BEE-spoke-data/govdocs1-by-extension huggingface dataset:
# Presentation: 663891

## Q-TOF MS/MS : de-novo sequencing

**Tip 1. ****Generally, Q-TOF ESI-MS shows multiple charged ions in the mass spectrum**** ****         e.g.  729(+2) = m/z  ********  m/z 729.8 = [M+2H]/2 ******** M=(729.8x2)-2=1457.6****      2. MS/MS fragmented ions : next page****      3. ****Leu(L)=Ile(I)**** and Phe(F)=Met(M) oxidation have the same MW****           ; It means that L or F can be replaced with I or M, respectively.    **

**y ions**

## Fragmentation of Peptides

## 2D 17=18=44~48 (spot No.) ; 710(+3) ([M+3H]3+) -  NLLLQGDAHLDPNVLQLTR (estimated sequen.)

**2D 17=18=44~48 ****(spot No.)**** ; 710(+3) ****([M+3H]****3+****)**** -  NLLLQGDAHLDPNVLQLTR ****(estimated sequen.)**

## 2D 17=18=44~48 ; 729(+2) -  VLAVEMDTFMDR

**2D 17=18=44~48 ; 729(+2) -  VLAVEMDTFMDR**

## 2D 17=18=44~48 ; 895(+2) -  LQGDAHLDPNDPQLTR

**2D 17=18=44~48 ; 895(+2) -  LQGDAHLDPNDPQLTR**

## 2D 16=26=27 ?

**2D 16=26=27 ?**

**2D 26=27**

**2D 16**

## 2D 30 ; 794(+2) -  VGSYQGEELYAPFK

**2D 30 ; 794(+2) -  VGSYQGEELYAPFK**

## 2D 33 ; 1012(+2) -  DLSQDDGLVPLVEEL~~~

**2D 33 ; 1012(+2) -  DLSQDDGLVPLVEEL~~~**

## 2D 36=38 ; 1194(+2) -  ~~~NGDLTTLADVVELK

**2D 36=38 ; 1194(+2) -  ~~~NGDLTTLADVVELK**

## 2D 39~43 ; 1102(+3) -  ~~~TSDLGDPNYPHLGLDYF~~~

**2D 39~43 ; 1102(+3) -  ~~~TSDLGDPNYPHLGLDYF~~~**

## 2D 54 ; 842(+2) -  NTVDDGSPLLLSSPLR

## 2D 54 ; 870(+2) -  LLVATEDNPFVVMFK

**2D 54 ; 870(+2) -  LLVATEDNPFVVMFK**

## 2D 60=61 ; 627(+2) -  MLGLFNDASDR

**2D 60=61 ; 627(+2) -  MLGLFNDASDR**

## 2D 71 ; 960(+2) -  WAMoxLGALGCVF~~

## 2D 74 ; 704(+2) -  LTYYTPEYETK

## 2D 77 ; 998(+2) – VMPGLLNSSPN~~(?)

## 2D 79 ; 727(+2) – WLSMQVARVVHK

**2D 79 ; 727(+2) – WLSMQVARVVHK**

## 2D 21=33=79 ; have same peptide m/z 727 (MW=1454) - aldolase

**2D 33**

**2D 21**

**2D 79**
# Presentation: 149510

## Neural Air Data Sensing and Control for Hypersonic Vehicles

**Neural Air Data Sensing and Control for Hypersonic Vehicles**
- Accurate Automation Corporation, Chattanooga, Tennessee

- Innovation

- Accomplishments

- Commercialization

- Government/Science Applications

**Points of Contact:**
- NASA LaRC, J. Larry Hunt, (757) 864-3732
- Accurate Automation, Chadwick Cox, (423) 894-4646
- 1994 SBIR Phase II; NAS1-20588

- Accurate Automation has developed a flush air data sensor comprised of a pressure-sensitive pad and a neural network module that can replace the pitot tube-based systems that provide air data on today’s aircraft.

- Developed a neural network-based flush air data sensor subsystem which provides:
- Reduced drag
- A smaller radar signature
- Increased reliability
- Improved aircraft safety
- Performed wind tunnel tests to train the system and to validate the data received

- Neural Air Data Sensor in NASA Langley’s
- Small Basic Research Tunnel

- This system can be used on all military and commercial aircraft.
- The National Transportation Safety Board has expressed interest in this technology because the system eliminates the danger posed by objects damaging or taping over a pitot tube.

- As the flush air data sensor can replace the pitot tube air data systems currently in use, the potential market is every aircraft manufacturer.  Because the system is flush with the body of the aircraft, maintenance costs are reduced because there is no tube that can be damaged by ground personnel.
- Accurate Automation has applied for a patent on this technology.
- Accurate Automation is in negotiation with a major aerospace firm for production of this product.
# Presentation: 524081

## 
Overview for the CLASS Workshop

December 11, 2003

- Overview for the CLASS Workshop
- December 11, 2003

***CLASS ******System****** Engineering Team (SET)***

## Mission

- The SET’s mission is to ensure the technical integrity of CLASS throughout the system’s lifecycle.

## Responsibilities

- Architecture
- Transition planning
- High-level design
- Low-level design oversight
- Implementation oversight
- Configuration Control Board (CCB) participation
- New technology evaluation
- Technical risk management

## Composition

- Up to three representatives from each development group
- Members are technical leads within their groups
- Members are appointed by the CPMT
- Current membership:
- OSDPD:	Amy Drew, Yue Ko, Barry Wishner
- NCDC:	Russ Nix, Pat Schafer
- NGDC-E:	Chris Wells (secretary), Doug Zirkle (chair)
- NGDC-T:	Ken Tanaka
- OSD:	Chung Wu

## Current Activities

- Ongoing design and implementation responsibilities
- Dual-site operations
- GOES
- Change assessment/CCB participation
- Coding standards revisions
- CLASS Architecture and Development Guide
- System description
- Long-term architecture
- Transition plans
- Guides to extendibility

## Key ARC Activities for the SET

- Help refine the CLASS vision
- Scope
- Scale
- Of particular interest: “science vs. IT”
- Establishment of detailed, consistent CLASS requirements
- Definition of CLASS customers and behaviors
- Users
- User groups
- Use case scenarios
- Identification of a set of representative users for SET interactions

## Closing

- Thank you!
# Presentation: 924797

## Opening Remarks

- Joseph Sedor

## Accident Summary

- FedEx Express Flight 647
- Boeing MD-10-10F, N364FE
- December 18, 2003
- Two injuries
- Postcrash fire

## Accident Summary

- Last leg of 4-day trip
- Oakland to Memphis
- First officer was the flying pilot
- Captain was a check airman
- Line check (altitude deviation)

## Accident Summary

- Normal climb, cruise, and descent
- Weather
- Wind, 320 at 21 knots, gusts to 26 knots
- Windshear advisories
-  10 knots on short final

## Accident Summary

- Normal initial approach with autopilot ON
- Windshear alert (approx. 1,500 ft agl)
- Autopilot off at 700 ft agl
- Stable approach through 200 ft agl

## NTSB Animation

**NTSB Animation**

## Slide 8

## Descent Rate at Touchdown

- Left gear descent rate: 12.5 fps
- Right gear descent rate: 14.4 fps
- Design limit:  10 fps
- Demonstrated reserve energy:  12 fps
- Vertical/lateral loads coincided

## Accident Summary

## Witness Video

**Witness Video**

## Witness Video

## Significant Findings

- No pre-existing failures
- Weather not a factor
- Excessive right gear loads
- Improper crosswind technique by the first officer
- Improper oversight by the captain

## NTSB Investigation

## FedEx MD-10 NTSB Staff

- Operations: D. Kirchgessner
- Survival Factors: C. Keegan
- Airworthiness: K. Pudwill/B. Murphy
- Human Performance: E. Byrne
- Airplane Performance: D. Crider

## FedEx MD-10 NTSB Staff

- Weather: K. Petty
- Air Traffic Control: S. Dunham
- Flight Data Recorder: G. Smith
- Cockpit Voice Recorder: A. Cushman
- Metallurgy: W. Rossey

## FedEx MD-10 NTSB Staff

- Writer: J. Moffett
- Editor: N. Coleman
- Graphics: G. John
- Presentations Editor:  S. Bennett
- Public Affairs: T. Williams

## Slide 18
# Presentation: 440108

## Cement Pulsation “Preventing Annular Flow After Cementing...”

- Minerals Management Service
- November 30, 2004
- Ken Newman
- Ed Smalley

## Today’s Highlights

- CTES
- Introduction & Key Products
- Recent R&D Projects
- Cement Pulsation to Prevent Annular Flow After Cementing in Offshore Gulf of Mexico
- Industry Need
- Technology Overview
- Instrumented Wellbore Results
- Field Test Results / Economics

## CTES Background

- Established in 1994
- ~ 25 employees
- Conroe, Texas
- Aberdeen, Scotland
- Products
- Wellbore intervention modeling software
- Data acquisition systems
- Engineering products
- Consulting services

## Biography of Ken Newman, P.E.

- MS Mechanical Engineering – M.I.T.
- 1985 - Joined Schlumberger
- 1988 - Dowell CT Engineering Manager located in Rosharon, TX
- 1990 - Dowell Worldwide CT Businessline Manager located in Paris, France
- 1993 - Joined Drexel (now Varco)
- VP - Tuboscope CT Products Marketing
- Founder and President of CTES
- Inventor of the SmarTract well tractor system
- Has published over 40 CT papers and articles
- Has over 12 patents

## Biography of Paul Brown

- MA Engineering - Cambridge University
-  12 years at Schlumberger
- Field engineer
- Research Scientist
- Engineering - developing downhole tools
- Coiled tubing specialist
- Senior Vice President of CTES, L.P.
- Leads software development
-  Has authored many CT papers and articles

## Biography of Ed Smalley

- B.S. Engineering – Kansas State
-  12 years at Schlumberger Wireline
- Field engineer, sales engineer, district manager
**HT/HP Specialist for Anadarko Basin**
- 11 Years at Gas Research Institute
- Business Development Director
**  ****Commercialization strategy, licensing of new E&P technology**
- V.P. Marketing & Business Development at CTES
- Leads business development activities

## Biography of Rick Behenna

- BS Petroleum Engineering – Montana Tech
- 12 Years at Halliburton Energy Services
- Halliburton Technology Center-Duncan, OK
- Operations Engineer – Algeria
- CT Software Technical Specialist
- Software Manager – CTES, L.P. – May 2002
- New Product Development
- Customer Support

## Major CTES Product Lines

- Software:  *Cerberus* Wireline, Coiled Tubing and Jointed Pipe modeling for directional/complex wells
- Forces
- Limits
- Hydraulics
- Fatigue (CT only)
- “PACA” completion design (packer/tubing issues)
- Data Acquisition Units:  *Orion, Sirius*
- Applicable to WL, CT, and Pumping services
- Data gathering, display and storage
- Real-time modeling and monitoring
- Engineering Projects and Consulting Services
# Presentation: 130114

## Locations for piezometers (P), diffusion samplers (T), and survey area at Occidental

- Notes on the scale & the location of boat GPS coordinates
-  - Waypoint numbers are indicated diagonally;
-  - Piezometers are indicated in italics [exact locations differ slightly from boat location]
-  - Diffusion sample locations are indicated by dots along transects
-  - Distance between WP 45 and 18 is 1584 feet (0.300 mile)
-  - length of ortho photo = 1946 ft
-  - Horizontal lines indicate distance from site boundary

**Locations for piezometers (*****P*****), diffusion samplers (T), and survey area at Occidental**
# Presentation: 485743

## 

MTAC

~ NEW OPPORTUNITIES ~

Marty Emery & Bob O’Brien

**MTAC**
**~ NEW OPPORTUNITIES ~**
**Marty Emery & Bob O’Brien**

## MTAC – New Opportunities

**More Immediate Release of Meeting Highlights and Minutes**
**Same Day Electronic Copies of Speaker Presentations**
**On-Going Communications**
**Formal Reports When Workgroups Complete Their Task(s)**
**PCC Distribution**
**USPS Officers**
**Quarterly MTAC Reports**

**Communication**

## MTAC Purpose

**	****The Mailers Technical Advisory Committee (MTAC) is a joint effort between mailers and the U.S. Postal Service to share technical information, advice and recommendations on matters concerning mail-related products and services in order to enhance customer value and expand the use of these products and services for mutual benefit.**
# Presentation: 687879

## Molecular Visualization: Spreading Kinematics and DynamicsSergei S. Sheiko, UNC Chapel Hill, DMR-0306787

**Molecular Visualization: Spreading Kinematics and Dynamics**Sergei S. Sheiko, UNC Chapel Hill, DMR-0306787

- Our research program develops a molecular-level understanding of spreading phenomena in thin films by visualizing individual molecules during flow.1,2 Our findings impacts microfluidics, lubrication, and surface coatings.
- Recently, we have discovered a dramatic phenomenon that wetting can induce scission of covalent bonds within branched macromolecules as they spread on a substrate.3 The macromolecule’s destruction occurs because its side chains stretch the polymer backbone to maximize the number of contacts with the substrate. This discovery opens intriguing opportunities for the design of macromolecules that induce tension and fracture on surfaces in a specific way.
- 1 *Phys. Rev. Lett. *_93_, 206103/1-4 (2004)
- 2 *Phys. Rev. Lett. *_94_, 237801/1-4 (2005)
- 3 *Nature* _440_, 191-194* *(2006)

**Adsorption-induced degradation of macromolecules. **(a) The molecular degradation of brush-like macromolecules with long side chains (*n*=140)** **was monitored using AFM after each sample was exposed for different time periods to a water/propanol (99.8/0.2 wt./wt.%) substrate. (b) The number average contour lengths measured after different exposure times *t* (●) are fitted assuming first-order reaction (solid line). The experimentally determined polydispersity index PDI=Lw/Ln  (■) shows good agreement with the computer simulation  of the scission process (dashed line).

**a**

**b**

## Molecular Visualization: Spreading Kinematics and DynamicsSergei S. Sheiko, UNC Chapel Hill, DMR-0306787

- In June-July 2006, Jonathan Alford continued his project on molding of single polymer molecules and block-copolymer micelles, which he had started last summer. The figure below shows a master of 30nm-sized spheres on a solid substrate (left) that were imprinted into a perfluoropolyether (PFPE) mold.

- Jonathan Alford (undergraduate student from the North Carolina A&T State University) learning AFM with his mentor Sherryl Yu (3rd year graduate student at UNC-CH)
# Presentation: 235452

## Strategies for Strong Collaborations with Community Tax Prep Centers and EITC Campaigns

- Belmont Shelter Corporation & the CASH Coalition of Western New York

## What is Belmont Shelter Corporation?

- Non-profit affordable housing agency established in 1977 employing nearly 100 associates dedicated to providing and expanding housing opportunities.
- Offices located in Buffalo, North Tonawanda, and Hamburg, NY.

## Belmont Shelter Corporation Housing Programs

- Section 8 Housing Choice Voucher
- Family Self-Sufficiency Program
- HUD Approved Housing Counseling Agency
- Housing Rehabilitation
- Housing Development
- Property Management

## Homeownership Programs

- Housing Counseling/Homebuyer Clubs
- Section 8 Housing Choice Voucher (HCV) Homeownership Program
-  HCV IDA Program
- Volunteer Return Preparation Program (VRPP)
- VRPP IDA Program
- Development of Affordable Single Family Housing

## Creating Assets, Savings, & Hope (CASH) Coalition

- Created December 2004
- Originally named the Economic Self Sufficiency Coalition of WNY
- Merger of Two Groups
- Self Sufficiency Steering Committee
- Asset Building Coalition of Western New York
- Based on Mutual Interests
- Focus on strategies that move people to self sufficiency

## CASH Coalition

- Strategic Vision:
- Increase the number of families who are self-sufficient in Buffalo & Erie County; to be achieved through increased economic development and coordinated, proactive community-based strategies.

## CASH Coalition

- Free Tax Preparation Network
- Financial Education
- Asset Building
- Workforce Preparation
- Communications

## CASH Coalition: Free Tax Preparation Network

**Goal**:
- Increase the amount of tax refunds and credits – including Earned Income Tax Credits (EITC) – flowing into the hands of hard working, low income families while reducing their use of paid preparer services & refund anticipation loans

## CASH Coalition: Free Tax Preparation Network

**Accomplishments**:
- Completed nearly 21,000 tax returns in two years
- Secured over $25 million in tax refunds and credits
- Saved taxpayers more than $3 million in tax-related fees

## Volunteer Return Preparation Program

- For Tax Season 2005, CASH received a grant from the John R. Oshei Foundation to expand the VRPP sites within the city of Buffalo.
- For the 2007 Tax Season, CASH will have 15 sites located throughout the City.

## Asset Building & Tax Preparation

- Client

- Greeter

- CASH Advisor

- Tax Preparer

- Self-Sufficiency Calculator

- Linked to Local Programs

## VRPP: Marketing 

- Marketing techniques utilized by the Coalition:
- Billboard Signs throughout the city
- Local Press (Print & Television)
- Paycheck Stuffers
- Free Tax “Newspaper”
- United Way “Day of Caring”
- Flyers at local community agencies, banks, supermarkets, etc.

## AFI VRPP IDA Program

- Pilot AFI program for residents of the 14215 zip code in Buffalo, NY
- Potential IDA participants will be recruited directly from the VRPP sites through the CASH advisor.
- Pilot program has a limited number of accounts available for Homeownership only, but may be expanded for 2008 Tax Season.
# Presentation: 685352

## Suspicious Activity Report Filing Trend for the State of Maine                                                                                       For the Period April 1, 1996 through December 31, 2007

***Total SARs: 8,497***

**Suspicious Activity Report Filing Trend for the State of Maine                                                                                       For the Period April 1, 1996 through December 31, 2007**

## Characterizations of Suspicious Activity for the State of Maine

- Note:  The pie chart represents the top nine characterizations plus additional characterizations in total.
-            An individual SAR may cite more than one characterization.  Hence, the number of characterizations detailed here significantly exceeds the total number of SARs.

**Characterizations of Suspicious Activity for the State of Maine**
**For the Period April 1, 1996 through December 31, 2007**

## Maine Mortgage Loan Fraud SAR Filing Trend For the Period April 1, 1996 through December 31, 2007

***Total SARs: 178***

- Note:  Suspicious Activity Report statistical data is continuously updated as additional reports are filed and processed.  For this reason, there may be minor discrepancies between the statistical figures contained in this report and those in previous FinCEN reports.  Annual numbers for this exhibit are calculated by ***Subject Address*** and not filer address; therefore, the annual totals appearing in the above graph do not match those in Section 1, Exhibit 8 (Characterization of Suspicious Activity by State & Territory by Year).

## Suspicious Activity Report Geographic Pattern for the State of Maine

**For the Period January 1, 2006 through December 31, 2006**

**Note: Statistics based on Filer Branch Address**

## Suspicious Activity Report Geographic Pattern for the State of Maine

**For the Period January 1, 2007 through December 31, 2007**

**Note: Statistics based on Filer Branch Address**
# Presentation: 192950

## PainArthritis Advisory CommitteeJuly 29, 2002 (afternoon session)

- James Witter MD, PhD
- Division of Analgesics, Anti-Inflammatory & Ophthalmologic Drug Products
- HFD-550

## Safety, Tolerance & Tolerability

- pain

- pleasure

- NSAIDs

- Opioids

## The Perfect Drug:

- Totally safe
- how safe is safe?
- who should decide?
- Totally effective
- Unfortunately, there is no such drug

## Safety Assessment:

- Before NDA approval:
- preclinical
- phase 1-3 studies
- NDA Approval
- if safe and effective
- After NDA approval
- MedWatch
- adverse event reporting system (AERS)

## Safety Assessment:

- Adverse events (before and after approval)
- patient reported
- investigator reported
- Patient global
- intended to catch the “something isn’t quite right experience” with an analgesic

##      Drug Safety

-              =
- Drug Information

## Post-NDA tools: CDER

**Utilization **

**External **
**Databases**:

-    **Passive surveillance**                        (AERS)

**Background                                         rates**

-      **Active**
**Surveillance**

## Risk Management (RM) Tools: Routine 

- Product labeling changes to:
- Add adverse events
- Add to contraindications, precautions, warnings (including BBW)
- Recommend monitoring (“directive monitoring”)
- Change indication to make second line

## RM Tools: Less Common

- Provide patient with information by:
- Medication Guides
- Dear Doctor Letters (DDL)
- FDA public announcements
- Patient registries: (voluntary or mandatory)
- Product withdrawal

## Post-Marketing: Lessons Learned 

- Labeling changes
- Largely ineffective for widely used drugs, complex messages
- “Failures”due to persistent adverse events or studies showing contraindications have been ignored have led to market withdrawal (i.e. Duract)
- Patient registries
- Useful for estimating the denominator in long-term safety but don’t manage risk *per se*

## July 29, 2002afternoon speakers

- Nathaniel Katz, M.D. (Harvard)
- Laura Lu, Ph.D. (FDA)
# Presentation: 263056

## Institute of Education Sciences 

**Terrific Start: **
**Important Challenges**

- Remarks prepared for the Institute of Education Sciences 2006 Research Conference
- June 16, 2006
- Washington, DC

- Robert C. Granger, Ed.D.

## Stage Setting

- NRC Report (1999)
- Education Sciences Reform   Act (2002)
- National Board for Education Sciences (2005)

## NBES 2006 Report

**Research priorities: **A clear, strong, long-term guide.
**IES’s plan for addressing priorities: **Great progress on important gaps.
**Review procedures**: Review standards and procedures of the highest merit.
**Activities to assure relevance**: Strong initiation of a number of important activities.

## NBES Report (2006)

- In summary, the NBES believes that the vision Congress had when it created the Institute for Education Sciences is being realized, and the Board is privileged to serve during this important period of transformation.

## Important Challenges: 

**A Personal View**

-  Understand **why** things work.
** **Understand **use**.

## 	Evidence-based practice in psychology (EBPP) is the integration of the best available research with clinical expertise in the context of patient characteristics, culture, and preferences. (May-June, 2006). 

## “The initial advocates assumed that progress in the technology of teaching had been slow just because (the) scientific method has not been applied: they assumed traditional practice was incompetent because it was not produced by experimentation...” (1963).
# Presentation: 131016

## The Data Buoy Co-operation Panel

## Drifting Buoy Co-operation Panel (1985)

- Rationale:
- More reliance on autonomous ocean instrumentation (e.g drifters) to replace OWS fleet
- Drifter data quality, quantity and timeliness all poor
- reasons not clear
- drifter reputation in severe decline
- Oceanographers do not put drifter data on GTS
- Recommendations and resolutions passed:
*Absolutely no effect on the data!!*
- Raise funds to appoint Technical Co-ordinator

## Drifting Buoy Co-operation Panel

- local user terminals

## Drifting Buoy Co-operation Panel

- local user terminals

## DBCP Technical Co-ordinators: present and past

## Data Buoy Co-operation Panel within JCOMM (IOC/WMO Joint Commission for Oceanography & Marine Meteorology)

- Data Buoy Co-operation Panel within JCOMM (IOC/WMO Joint Commission for Oceanography & Marine Meteorology)

## Data Buoy Co-operation Panel:some practical achievements

- Improvements in data quality and quantity
- Formation of regional action groups
- Establishment of effective QC procedures
- QC monitoring network
- QC system at Argos for data entering GTS
- Involvement of oceanographic community
- Active forum for data buoy issues
- Annual sessions, technical workshops and documents
- Website and related discussion fora

## Regional Action Groups

## Quality, quantity, timeliness

- RMS errors – air pressure

## Quality, quantity, timeliness

- 1979 - FGGE

## Quality, quantity, timeliness

- 1987

## Quality, quantity, timeliness

- 2005

## Quality, quantity, timeliness

## Quality, quantity, timeliness

## Targets:
Achieve 1250 by JCOMM-II
Keep Mike Johnson sane

- Targets:
- Achieve 1250 by JCOMM-II
- Keep Mike Johnson sane

- Quality, quantity, timeliness

## Quality, quantity, timeliness

## Quality, quantity, timeliness

- Percentage of Argos data available in near real time

## DBCP Technical Document Series

## http://dbcp.noaa.gov/dbcp

## http://dbcp.noaa.gov/dbcp

## http://dbcp.noaa.gov/dbcp

## DBCP-I   Toulouse, 1985

## DBCP-X           La Jolla, 1994

## DBCP-XX  Chennai, 2004

## The future...

- Implementation strategy:
- Overall framework for the work of the Panel
- Statement of objectives
- Fostering of action groups
- Interaction with manufacturers, communications service providers, QC agencies and users
- Close involvement with development of JCOMM Observations Programme
- New challenges
- Deployment opportunities and strategies
- Vandalism
- New chemical and bio sensors
- New communications and smart platforms
# Presentation: 034336

## Hot Items! Additional information

- Nancy Soreide NOAA/OAR/PMEL
- Seattle Regional Meeting (PRT-54)PMEL, Seattle, WA April 8, 2003

- A news web site designed to facilitate communication between organizations

## Technical specifications

## Technical information

- Database
- All entries stored in a MySQL database
- Security
- Secure Socket Layers (SSL) ensures log in without compromising user name and/or password
- Information encrypted before entry into the database
- Web pages secured to internal users or password protected
- Server side technology
- Apache web server with PHP hypertext parser and scripting language
- Refresh and updates are automated
- Hosted on NOAA Seattle Campus NOC Web Server (24x7)
- Client side
- Cascading style sheets, HTML, JavaScript

## Input Forms

## Free Form Story Input Form

## Input Form for Publication

## Input Form for Media Contact

## Input Form for Conference, Meeting or Workshop

## Local hot items web pages

## Slide 10

## Local hot items page

- http://lab_name.hotitems.noaa.gov

## Items can be sent forward to HQ Hot Items page from the local hot items pages

- Local hot items Web Pages

- HQ Hot Items Web Page

## To “push” from the local hot items to the HQ Hot Items

## Story was “pushed” onto the HQ Hot Items

## NOAA News & Information Web SiteBuilding a corporate NOAA

- One panel for each NOAA Region
- Each region can push local items from their regions’ hot items to the NOAA Regional Hot Items
- Benefits
- Improved awareness of NOAA activities across all regions
- Helps in creating an inventory of available services for each region
- Ensures that NOAA regions are aware of each other’s activities
- Ensures that employees are aware of each other's available products and services

## NOAA Regions

## NOAA Regions

- <date/time>

- _[http://heron.](http://heron.pmel.noaa.gov/regional/regionalview1.php)__[pmel](http://heron.pmel.noaa.gov/regional/regionalview1.php)__[.](http://heron.pmel.noaa.gov/regional/regionalview1.php)__[noaa](http://heron.pmel.noaa.gov/regional/regionalview1.php)__[.](http://heron.pmel.noaa.gov/regional/regionalview1.php)__[gov](http://heron.pmel.noaa.gov/regional/regionalview1.php)__[/regional/regionalview1.](http://heron.pmel.noaa.gov/regional/regionalview1.php)__[php](http://heron.pmel.noaa.gov/regional/regionalview1.php)_

## NOAA Regions

- <date/time>

- _[http://heron.](http://heron.pmel.noaa.gov/regional/regionalview1.php)__[pmel](http://heron.pmel.noaa.gov/regional/regionalview1.php)__[.](http://heron.pmel.noaa.gov/regional/regionalview1.php)__[noaa](http://heron.pmel.noaa.gov/regional/regionalview1.php)__[.](http://heron.pmel.noaa.gov/regional/regionalview1.php)__[gov](http://heron.pmel.noaa.gov/regional/regionalview1.php)__[/regional/regionalview1.](http://heron.pmel.noaa.gov/regional/regionalview1.php)__[php](http://heron.pmel.noaa.gov/regional/regionalview1.php)_
# Presentation: 939718

## Slide 1

## Slide 2

## Slide 3

## Slide 4

## Slide 5

## Slide 6

## Resource Page

- The Resource Page contains the following:
- Link to samples of all IB applications.  (Note: IB staff will provide PDF copies of  electronic applications to be included on the page).
- A sample EZ application with watermark designating it as a sample will also be displayed.
- -Copy of Sample form 159
- -Frequency Coordination Pages/Coordination Data
- -EZ Schedule B Calculations
- -OET Bulletin 65

## Slide 8

## Slide 9

## Slide 10

## Slide 11

## Contact Us (Sample Info) 

-  The Contact Use Section contains the following links
- - Call Us, IBFS Help Line
- _- IBFS Contacts_ (_[http://www.fcc.gov/fcc-bin/findpeople.pl](http://www.fcc.gov/fcc-bin/findpeople.pl)_ )
- _IB Staff List_ – (see below for details)
- The IB Staff List page will contain the following information.
- Thank you for using the IBFS.  We are here to assist you with your electronic filing.  The Commission hours are from 9:00 am to 4:30 pm Monday through Friday.  You can contact the IBFS Help Line at 202-418-2222.
- Below are contacts for specific offices.
- - For help using the IBFS:
- - Shawana Burnham – phone: 202-418-7932; email: _[Shawana.Burnham@fcc.gov](mailto:Shawana.Burnham@fcc.gov)_
- - MaryJane Solomon – phone: 202-418-0593; email: _[MaryJane.Solomon@fcc.gov](mailto:MaryJane.Solomon@fcc.gov)_
- - Jacki Ponti – phone: 202-418-0436; email: _[Jacki.Ponti@fcc.gov](mailto:Jacki.Ponti@fcc.gov)_
- - Tom Sullivan – phone: 202-418-0411; email: _[Tom.Sullivan@fcc.gov](mailto:Tom.Sullivan@fcc.gov)_

## Slide 13

## Slide 14

## Logging In/Application Filing in MyIBFS

- Logging In/Application Filing in *My*IBFS

**Filing and Paying Online**

_**MyIBFS Services**_
***Linked to FRN Used to      Login to MyIBFS***
**Tracking My Filings**
**Creating Drafts**
**Routing Drafts**
**Monitoring Other Filings**
**  ****(Future)**
**Corresponding w/FCC on my filings (Future)**
**Filing Applications**
**Paying For Applications**

**File Application: who are you?**
**Applicant FRN/PW**
**Contact FRN/PW**
**Payer FRN/PW**

**Login with FRN**
**Can be:**
**Preparer FRN/PW**
**Applicant FRN/PW**
**Contact FRN/PW**

## Slide 16

## Slide 17

## Slide 18

## Slide 19

## Slide 20

## Slide 21

## Slide 22

## Slide 23

## Slide 24

## Slide 25

## Slide 26

## Slide 27

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## Slide 33
# Presentation: 660634

## Symlin®Amylin PharmaceuticalsNew Drug Application (21-332)

**Advisory Committee Meeting**
**Bethesda, Maryland**
**(July 26, 2001)**

**Center for Drug Evaluation and Research**** **

## EFFICACY  -  Robert I Misbin, MD

**Type 1 diabetes**
**Type 2 diabetes**
- SAFETY - Dragos Roman, MD
**Hypoglycemia**

## Type 1 Diabetes

** ****8.2            **8.9**            8.8            **8.9**            9.0            8.9            **8.9**   **

## Trial 117 - Type 1 Diabetes

**   ****Stable metabolic regimen**
**   ****HbA1c at least 8% at screening**
-    Patients to remain on their usual diet, type of insulin, insulin regimen and exercise regimen

## TYPE 1 DIABETESTRIAL 117

**Mean data at baseline**
**38 years old**
**16 years of diabetes**
**BMI  25**
**HbA1c  9.0%**
**50 units insulin/day**

## American Diabetes Association Recommendations

**HbA1c  <7%           Goal of therapy**
**HbA1c  >8%           “additional action             ****	****	****	****	**** suggested”**

## Trial 117 - Type 1 Diabetes

**   ****Stable metabolic regimen**
**   ****HbA1c at least 8% at screening**
-    Patients to remain on their usual diet, type of insulin, insulin regimen and exercise regimen** **

## Type 1 Diabetes Study 117

## Type 1 Diabetes - Trial 117

**“****Early Glycemic Responder” Subgroup**
**Reduction in HbA1c at least 0.5% units at 4 weeks**
**Show data at 4 and 26 weeks**

## Early Glycemic Responders Study117

## Early Glycemic Responders 117

## Early Glycemic Responders 117

## Slide 13

## Pramlintide Treatment of Type 1 Diabetes	 

**3-4 injections per day in addition to insulin****	****	**
**More severe hypoglycemia than reducing HbA1c with insulin alone**
**Weight loss relative to insulin alone **

## Type 2 Diabetes

## TYPE 2 DIABETESTRIAL 123

**Mean data at baseline**
**58 years old**
**13 years of diabetes**
**BMI 30.6  **
**HbA1c  9.4%**
**56 units insulin/day**

## Trial 123 - Type 2 Diabetes

**   ****HbA1c at least 8% at screening**
**   ****Patients to remain on their usual diet, insulin regimen, and exercise regimen**
**“**changes in** **insulin doses were not encouraged in order to limit the impact of alterations in insulin dosing on glycemic control.**”**

## Type 2 Diabetes Study 123

- ITT population

## Type 2 Diabetes Metformin

- Annals of Internal Medicine 1999; 131:185

**-****0.9**

**Insulin +**
**Metformin**

**Insulin +**
**   ****Placebo**

## Slide 20

## Type 2 Diabetes Study 123

- ITT population

## SAFETY REVIEW

**Dr Dragos Roman**
# Presentation: 526712

## Automotive Paint Study

- Prepared By:

- May, 2005
- MRSI #  05-9743-054

## Paint Spray Gun Usage

**Paint Spray Gun Usage**

*Base: Currently Use A High Transfer Efficiency Paint Gun (34)*
**Base: Total (38)*

**Use High Transfer Paint Spray Gun**

**89% Use A High Transfer Efficiency Paint Spray Gun***

**Length Of Time Using High Transfer Efficiency Paint Gun**

**Don’t Use High Transfer Paint Spray Gun**

## Paint Spray Gun Usage

*Base: Currently Use A High Transfer Efficiency Paint Gun (34)*
**Base: Total (38)*

**High Transfer Efficiency Paint Spray Guns Save Money In Paint Costs**

**Follow Manufacturers’ Recommended Instructions Using High Volume Low Pressure Nozzles**

**YES**
**100%**
# Presentation: 922510

## Emergency Preparedness: Education and Training for Treating the Pediatric Population

**Michael Shannon, M.D., M.P.H.**
- Director
- The Center for Biopreparedness
- Professor and Chair
- Division of Emergency Medicine
- Children's Hospital, Harvard Medical School
- Boston, MA

## Unmet Needs in Pediatric Emergency Preparedness

- Comprehensive, school-based emergency preparedness protocols
- Pediatric protocols in every hospital
- Pediatric surge capacity plans
- Education/training on unique issues
- Community involvement
- Identification and reunification of children and parents

## Key Issues in Education & Training

- Many first responders remain inadequately trained in pediatric aspects of disaster response
- Training programs are failing to provide specific pediatric training
- There has been little development of DVDs/videos as training tools

## Decontamination of Children: Preparedness and Response for Hospital Emergency Departments

- Video provides step-by-step demonstration of decontamination process in real time
- Training tool for emergency responders and hospital emergency department staff

## Video-based Training Topics

- Responding to mental health needs of children after disaster
- Development of comprehensive, school-based disaster plan
- Specific to children:
- Management of mass casualty incidents
- Management of bioterrorism and other infectious emergencies
- Management of radiologic emergencies

## Identification and Reunification of Children After a Mass Casualty Incident

- Requires means of rapidly collecting information on arriving casualties (e.g., digital photos)
- Photo indexing
- Site where arriving parents can review photos
- System for presenting select photos
# Presentation: 930802

##      2005Hurricanes       in   NDFD

*David P. Ruth                                                                                   December 01, 2005*

## Notes on Presentation

*** ******Slideshow contains animated GIFs.   In order to see them, you must actually play the PowerPoint slideshow (F5).***
***  ******Slideshow has been prepared as part of an ongoing OST action to provide information on NDFD element readiness. ***

## Hurricane Dennis

**Hurricane Dennis**

## Hurricane Dennis Winds

- Forecast
- issued
- Thursday
- morning
- July 7

- Forecast
- issued
- Friday
- morning
- July 8

- Forecast
- issued
- Saturday
- morning
- July 9

## Hurricane Dennis Waves

- Forecast
- issued
- Thursday
- morning
- July 7

- Forecast
- issued
- Friday
- morning
- July 8

- Forecast
- issued
- Saturday
- morning
- July 9

## Hurricane Dennis QPF

## Hurricane Katrina

**Hurricane**** Katrina**

##      Katrina visits Florida

- Forecast
- issued
- Thursday
- morning
- Aug 25

## Katrina’s eye forecast to  pass over New Orleans

- Forecast
- issued
- Saturday
- morning
- Aug 27

## Forecast issued at Katrina’s landfall

- Forecast
- issued
- Monday
- morning
- Aug 29

## 5 day hourly forecast evolution valid 00z Monday evening

- NDFD
- Wind

## Katrina Wave Heights

- Forecast issued Saturday
-    morning August 27

- Forecast issued Sunday
-    morning August 28

## 5 day hourly forecast evolution valid Monday 12z-00z

- NDFD
- Wave

## Katrina QPF

- NDFD
- QPF

- Observed

## 3 day hourly forecast evolution valid Monday 18z-00z

- NDFD
- QPF

- Observed

## Hurricane Rita

**Hurricane Rita**

## Rita Passes South Florida

- Forecasts issued Tuesday morning

## Early tracks for Rita in Texas

- Forecast issued Tuesday morning

**Early tracks for Rita in Texas**

## Early tracks for Rita in Texas

- Forecast issued Thursday morning

**Early tracks for Rita in Texas**

## Rita’s Winds and Waves

**Rita’s Winds and Waves**

## Rita’s QPF

**Rita’s**** QPF**

- Forecast issued Thursday morning

- Forecast issued Friday morning

- Observed

## Rita’s QPF at Landfall

- Forecast issued Thursday morning

- Forecast issued Friday morning

- Observed

## Hurricane Wilma

**Hurricane Wilma**

## Wilma’s Winds and Waves

- Forecasts issued Saturday morning

## Timing arrival of Wilma’s winds

- Thursday morning forecast
-     for Sunday evening

- Friday morning forecast
-   for Monday evening

**Timing arrival of Wilma’s winds**

## Timing arrival of Wilma’s winds

- Saturday morning forecast
-   for Monday afternoon

- Sunday morning forecast
-   for Monday morning

## Timing arrival of Wilma’s waves

- Thursday morning forecast
-    for Saturday night

- Friday morning forecast
-    for Monday

## Timing arrival of Wilma’s waves

- Saturday morning forecast
-    for Sunday night

- Sunday morning forecast
-   for Sunday night

## Wilma’s QPF

- Forecast issued
- Saturday morning

**Wilma’s QPF**

- Forecast issued
-  Sunday evening

- Forecast issued
-  Sunday morning

## Wilma’s QPF versus QPE

- Forecasts
- Issued
- Sunday
- evening
# Presentation: 818463

## ACE Tracer Species

- Kaley Walker, Chris Boone, Randall Skelton and Peter Bernath, University of Waterloo
- Lucien Froidevaux and MLS team, JPL
- Marty McHugh, GATS
- Matt Toohey, Pierre Fogal, Stella Melo and Kim Strong, University of Toronto
- September 22, 2005

## ACE Tracer Species Data

- ACE-FTS provides profiles of N2O, CH4, CFC-11, CFC-12 and HCN
- ACE-FTS v2.2
- Retrievals cover range from (km):
- 	N2O:  ~5 to 60 km, CH4:  ~5 to 70 km, CFCs:  ~8 to 25 km HCN: ~8 to 28 km
- Microwindows used:
- N2O:  13 between 1134 and 1887 cm-1
- 	        41 between 2188 and 2527 cm-1
- CH4:  29 between 1245 and 1463 cm-1
- 	        35 between 2610 and 2889 cm-1

## N2O:  ACE-FTS vs. MLS

- Above 75 hPa, ACE-FTS is ~10% higher than MLS

**Lucien Froidevaux**

**Notes:**
Above ~18 km = 80 hPa; ~2 hPa = 42 km

## CH4:  ACE-FTS - HALOE

- ACE-FTS is          ~10% higher throughout from 18 to 55 km
- 29 Coincident Events in July 2004 at ~66 N (within 500 km and 3 hours) plus 2 on Jan 17 (60 S) and 1 on Feb 12 (48 N) in 2004
- ACE-FTS version 1.0, HALOE v19

**Marty McHugh**

## Middle Atmosphere Nitrogen Trend Assessment (MANTRA)

- Canadian balloon mission to study the changing chemical balance of the mid-latitude stratosphere
- vertical profiles of stratospheric species that control the mid-latitude ozone budget, along with dynamical tracers
- Four campaigns conducted at Vanscoy, Saskatchewan    (52N, 107W) during turnaround
- Late August – early September 			       in 1998, 2000, 2002, 2004
- Suite of up to 11 instruments 				 flown on single gondola

## (Very) Preliminary:  ACE - MANTRA

- MANTRA 1998
- ACE 2004 !!!

**Matt Toohey**

**Balloon**
- N2O:  FTS
- HNO3:  FTS
**Ground-based**
- NO2:  UV-vis

**Notes:**
v2.2 ACE, FTS: HNO3, N2O, GB: NO2;  need to generate climatology do comparisons to zonal means, log scale to get everything on there 

## Improvements for ACE-FTS

- Isotopologue retrievals
- Currently included in v2.2:  CH4 (311), CH4 (212), H2O
-  Next version to include N2O, O3 and more

**Chris Boone**

**Notes:**
Enhancement of 10% near 30 km, chemistry(reactions, condensation), transport (mass effect – diffusion faster for lighter ones)

## ACE tracer species data available

- Newest ACE data to be put into AVDC
- ACE-FTS v2.2 will be in very soon
- Potential for interesting comparisons with:
- HIRDLS:  N2O, CH4, CFCs ...
- TES:  CH4
# Presentation: 685645

## Systematic errors in GFS 0-16 day forecasts for JJA2003

- Glenn.White@noaa.gov
- Global system resolution change Oct. 2002:
- T254, 64 levels 0 to 84 hrs
- T170, 42 levels 84 to 180 hrs
- T126, 28 levels 180-384 hours
- New background error; changes to horizontal diffusion
- More satellite data
- Errors relative to GFS analysis
- Most of errors for 000 GMT; full diurnal cycle not included
- Errors for 1200GMT are similar

***Before:***
***T170, 42 levels to 180 hrs***
***T62, 28 levels 180-384 hrs***

## Analysis cycle places eastern ocean stratus clouds too far to west; forecasts decrease low-level stratus clouds.

- Vertical distribution changes a little after 7.5 days when resolution changes
- Stratospheric cold bias keeps growing and becomes much larger than tropospheric bias
- Warm bias just below tropopause
- Intensity of tropical divergence increases in first 24 hours, then decreases

- Analysis cycle places eastern ocean stratus clouds too far to west; forecasts decrease low-level stratus clouds.

## Slide 3

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## Slide 28

## Slide 29
# Presentation: 308495

## Library of Congress – Storage Architectures for Digital Collection Preservation

**Rajeev Bhardwaj**
**Director, Product Management**
**Data Center Business Unit (DCBU)**

## Outline

- Address the **role of a Storage Area Networks (SANs)** in storage architectures for digital collection preservation in terms of:
- Costs of long-term storage, including media and facilities
- Data integrity
- Migration to new technologies
- Security

**Clients**

**Servers**

**SAN**

**Storage Devices**

## How can a SAN Reduce Costs of Long-Term Storage?

**How can a SAN Reduce Costs of Long-Term Storage?**

## Data Integrity

## Migration to New Technologies

- Enable SAN-based storage lifecycle management
- Driven by technology refresh
- Online data migration across heterogeneous arrays
- Network-hosted storage virtualization provides non-disruptive data migration
- Network-hosted storage virtualization provides high-performance migration capabilities
- Migrate multiple TBs of data per hour
- Data integrity checks
- Ensure integrity of migrated data on new array
- Cryptographically erase data on old array

**Data ****Migration**

- Old Array

- New Array

- Application Servers

**Application I/O**

**Data Migration**

## SAN Security for Digital Collection Preservation

**Port Security**
**Fabric Binding**
**Host/Switch Authentication **
**iSCSI CHAP Authentication**

**SSHv2, SNMPv3, SSL**
**Centralized AAA**
**- *****RADIUS, TACACS+***
**Role Based Access Controls **
**VSAN based RBAC**
**IP ACLs**

**Security for Data-in-Motion**
***- IPSec for FCIP & iSCSI***** **

**Device Authorization ****and Authentication**

**VSANs**
**Hardware Zoning**
**LUN Zoning**
**Read-only Zones**

**Server and Target ****Access Controls**

**Management ****Access Controls**

**Data Integrity ****and Encryption**

**SAN Security for Digital Collection Preservation**

**Security of Data-at-Rest**
***- Tapes and Disks***** **

## Summary 

- Reduce the costs of long-term storage, including media and facilities:
- Fabric consolidation with large-scale SAN Directors, VSANs, SAN Routing
- Storage Virtualization
- Off-site Storage
- Provide Data Integrity
- CRC checks on a per frame basis
- Data Integrity for data-at-rest
- Enable migration to new technologies
- High performance data mobility
- Heterogeneous capability
- Preserves data integrity
- Robust and holistic security capabilities
- Management access controls
- Server and Target access controls
- Device-level authorization and authentication
- Data integrity and encryption of data-at-rest and data-in-motion

- SANs play a strategic role in storage architectures for digital collection preservation
# Presentation: 914196

## Historical California Fish Landings Data, 1930-1968(Continuation proposal)

- Alec D. MacCall and Don Pearson
- NMFS/Southwest Fisheries Science Center
- Meisha Key
- California Department of Fish and Game

## Scientific Rationale

- _Marine organisms are integrators of their environment_
- Biology can inform the physics
- Fish distribution (movements) and reproductive success reflect ecosystem conditions and processes
- Especially subsurface conditions and structure
- This is a rare biological data set with sufficient detail and resolution to compare with physical observations
- Physics can inform the biology/management
- Environmentally explicit (EE) assessment and harvest policy is the “ideal”
- Sardines are one of very few fish stocks with EE management
- We have a temperature-dependent harvest policy—but it needs tuning
- The Pacific Coast has an intense low-frequency signal to work with
- Many more fish stocks would benefit from EE harvest policies
- Currently available time series are too short and recent to support

## Scientific Rationale (2)

- Sardine productivity (slope of bottom graph) is closely associated with the PDO (top)
- Mechanisms are still not clear
- Appear to be related to strength of the California Current
- Proposal fills in 1931-1968
- When and how will it change again?  What should we do?
- Not only sardines, but many other fisheries are influenced
- Groundfish now disaster status
- Many salmon stocks now listed under Endangered Species Act

**Monthly species**
**summaries**

**Individual fish**
**landings**

**Data already captured**

## General Approach for Project

| PI will: | Contractor will: |
| --- | --- |
| Send microfiche to contractor    |  |
| Develop procedures and format |  |
|  | Key data (details on next two slides) |
|  | Send each completed year to PI |
| Put data in provisional database for QA/QC |  |
| Construct web-accessible relational database (SQL Server will be platform) |  |
| Data will be made available through:
PacFIN        www.psmfc.org/pacfin/
CALCOM     www.noaa187.ucsc.edu/ |  |

## Data Sample

*A monthly column sum*

- Images are microfiche photos of paper printouts
- Page format
- Strip format (ca. 9ft)
- This is a fairly typical image taken from the top of a strip
- Original microfiche is a little easier to read, especially for lightly printed numbers

## Scope of FY06 and FY07 Tasks

|  | Sub projects in priority order | # of Lines |
| --- | --- | --- |
| FY 2006 | Species/origin/month summaries 1931-1968 | 700,000 |
| FY 2007 | Individual landings receipts 1950-1968 | 4,650,000 |

- Given the large quantity of data, project was divided into two parts accordingly
- Monthly Summaries (2006) - Useful by themselves and for subsequently checking individual landings data
- Began in September, with completion possible in next two months
- Individual Landings Data (funding is requested in FY 2007)
- Again, begin with most recent year and begin backwards
# Presentation: 762414

## geWorkbench Gridification

**caBIG Y3 Project**

## Overview

**Develop caGRID versions of select analyses**
- Hierarchical Clustering.
- Self Organizing Maps.
- ARACNE (Algorithm for the Reconstruction of Accurate Cellular Networks)
**caSCRIPT – script interface to geWorkbench and caGRID**

## caWorkbench GUI

_*Configuration File Prescribes Pluggable Components\Modules*_
- <plugin id="Example" name="Example" 	class="org.geworkbench.components.example.ExampleComponent" 	source="example">
-     <gui-area name="VisualArea"/>
- </plugin>

## Analysis Invocation Pre-Gridification

## Analysis Invocation Post-Gridification

**GUI fashioned after **_[caGRID](http://cagrid-browser.nci.nih.gov/cagrid-browser/)__[ Browser](http://cagrid-browser.nci.nih.gov/cagrid-browser/)_

## caSCRIPT
# Presentation: 733776

## Space Environment Center Data Acquisition & Dissemination

**                       **
- Direct satellite receive systems
- Dedicated telephone circuits
- Department of Defense communication circuits
- Electronic mail delivery
- Internet FTP communication

**                            **
- SEC web page
- Gopher system
- Majordomo
- Alerts, warnings, and advisories
- Information Dissemination System (IDS)
- Weather wire

**Space Environment Center Data Acquisition & Dissemination**

**Jim Abeyta**
- NOAA Space Environment Center

**General Data Acquisition & Dissemination**

**SEC Data Acquisition**

**SEC Data Dissemination**