BEE-spoke-data/govdocs1-by-extension huggingface dataset:
# Presentation: 672183

## Polar observations of the characteristics of the dayside high altitude cusp

- T. A. FRITZ, J. CHEN, J. NIEHOF
- Center for Space Physics at Boston University

- Polar PI conference call
- December 3, 2004

## The Chapman Ferraro Cusp

**The Chapman Ferraro Cusp**

**Observationally Polar has shown that the cusp is a large region and is the site of continuous large fluxes of energetic particles.**
**At BU we feel that we have established that these energetic particles are produced there and we are searching for the mechanism that does that.**

- 10

- 10

## Cusp Energy Density comparison published by Chang et al., 1998

**June 20, 1996**

## 8/27/96

- Total Pressure (x10)

- Magnetic Pressure

- Plasma Prep. Pressure

## 8/27/96

- 9/18/96

- 4/20/99

- 4/24/99

## 8/27/96

**8/27/96**

- Btotal
- Vx
- MICS He++
- MICS O+6
- MICS H+
- Hydra ions

## 8/27/96

- Btotal
- P prep (electrons)
- P prep (ions)
- Ion Density (Hydra)
- Ion Density (Tide)
- EFI Density

## 9/18/96

- Btotal
- Vx (km/s)
- MICS He++
- MICS O+6
- MICS H+
- Hydra ions

## Btotal  

- Btotal
- P prep (electrons)
- P prep (ions)
- Ion Density (Hydra)
- Ion Density (Tide)
- EFI Density

## Btotal

- Btotal
- Vx (km/s)
- MICS He++
- MICS O+6
- MICS H+
- Hydra ions

**4/20/99**

## Btotal  

- Btotal
- P prep (electrons)
- P prep (ions)
- Ion Density (Hydra)
- Ion Density (Tide)
- EFI Density

## 4/24/99

- Btotal
- Vx (km/s)
- MICS He++
- MICS O+6
- MICS H+
- Hydra ions

## Btotal  

- Btotal
- P prep (electrons)
- P prep (ions)
- Ion Density (Hydra)
- Ion Density (Tide)
- EFI Density

## Ions

**Ions**

**Electrons**

**9/18/96**

**R=-0.86**

**R=-0.87**

**R=-0.93**

**R=-0.95**

## 8/27/99

**Ions**

**Electons**

**8/27/99**

**R=-0.90**

**R=-0.95**

**R=-0.83**

**R=-0.91**

## Slide 16

## Slide 17

## Slide 18

## Slide 19

## Slide 20

## Conclusions:

**We have attempted to understand the components that must provide the energy density within the high-altitude cusp.**
**With the advertised data from the Polar team there is a deficiency of the measured plasma pressure in creating a balance.**
**The local plasma from the solar wind creates the diamagnetic cavity.**
**The perpendicular pressure provided  by both the ions and electrons are highly anti-correlated with the turbulence as expected but  the electrons surprisingly show a higher level of anti-correlation. **
**The sense of the polarization of the observed electric component of the  turbulence in the direction perpendicular to B can provide resonate acceleration of ions rapidly to high energies.**
# Presentation: 285877

## Highlights from the 1998 to 2003 U.S. National PFD Wear Rate Observational Studies

- Thomas W. Mangione, Ph.D.
- Maria Rangel, MPH
- JSI Research & Training Institute, Inc.
- Boston, Massachusetts
- Under contract to the U.S. Coast Guard,
- Funding from the Wallop-Breaux Trust Fund
- Mr. Peter Eikenberry, Program Officer
- All data and opinions are the responsibility of JSI authors and not necessarily the view of the U.S. Coast Guard

## Methods Used in Observational Studies

- Random, stratified sample of states (n=30)**(19 coastal states and 11 inland states)**** **
- 4 locations in each state (CA=8) (n=124)**(Original selection of sites aided by local U.S Coast Guard and Auxillary personnel plus state boating officers and/or fish/game officers; sites attempted to reflect range of boating venues in state but needed to be in relatively close proximity to each other)**** **
- Each site observed for approximately 4 hours, on a Saturday or Sunday morning or afternoon between July 4th and Labor Day.**(Viewing locations were on land at narrowings, bridges)**** **
- Trained observers worked in pairs with one calling out information using high powered binoculars and other recording trading off frequently

## Methods Used in Observational Studies

- Each year approximately 14,000 boats with 38,000 boaters were observed.
- Six year totals (1998-2003) were:
- 85,266 boats
- 229,891 boaters

## Overall Wear Rates 1998 to 2003

## Annual Wear Rate Trends 1998 to 2003(Adult Boaters only, excluding PWCs)

## Adult Annual Wear Rate Trends Power Boats1998 to 2003

## Adults Annual Wear Rate Trends Paddle Boats1998 to 2003

## Adult Annual Wear Rate Trends Sail Boats1998 to 2003

## Youth Annual Wear Rate Trends 1998 to 2003(excluding PWCs)

## Youth Wear Rates by Mandatory Law Status 1998 to 2003(excluding PWCs)
# Presentation: 250602

## MAXIM Periscope Module

**Team Lead**
**Jennifer Medlin Bracken**
**25 April 2003**

## Presentation Agenda

**Introduction****	****	****	****	****Jennifer M. Bracken**
**Science Overview****	****	****	****H. John Wood**
**Instrument Systems****	****	****	****Deborah A. Amato**
**Optical Analysis****	****	****	****Dennis C. Evans**
**Mechanical Systems****	****	****	****Joseph W. Pellicciotti****	****	****	****	****	****David J. Palace****	****	****	****	****	****	****Michael F. Correia**
**Structural Analysis****	****	****	****Jeffrey A. Bolognese**
**Electro-mechanical****	****	****	****Jason G. Budinoff**
**Thermal****	****	****	****	****Robert A. Chalmers**
**Electrical****	****	****	****	****C. Paul Earle**
**Cost Modeling****	****	****	****	****William  M. Lawson**
**Closing Comments****	****	****	****Jennifer M. Bracken**

## Study Objectives

**How do you make these light weight mirrors so they are flat to better than ********/400?**
**How do you hold these mirrors with actuators to move them by ~nm over microns of range?  Which Actuators and controlling electronics?  Do you put actuators on all the mirrors?**
**How does the structure provide an environment suitable to maintain the mirror figure and stability?**
**Do we need internal metrology?  How to implement?**
**How do we register one module’s mirror surfaces to another modules mirror surfaces at the micron level?**
**How to mass produce these?  By how much does this save costs?**
**What would the alignment procedures be?**
**Trade Studies- three different mirror module sizes,..**
**We need the usual IMDC cost/mass/power inputs.  Drawings.**

## Customer Notes
# Presentation: 722535

## NEA Ullage Washing Testing

- With a Vented Fuel Tank

## Outline

- Background
- Ullage Washing Data
- Model Validation
- Hydrocarbon Effects Data
- Temperature Effects Data

## Background

- Obtained Nitrogen Supply System from Air Liquide to Examine Fuel Tank Ullage Washing
- Utilized Existing Test Article
- Primary Task is to Characterize the Ability of Nitrogen to Inert an Empty Fuel Tank
- Effective of Nitrogen Purity, Flow Rate
- Effective Ullage Temperature / Hydrocarbon Concentration
- Develop Empirical Relationships and Varify Existing Models

## Slide 4

## Slide 5

## Nondimensional Time

- Want to Express Time in Terms of Volume Delivered
- Volumetric Tank Exchange =                       Time * Volume Flow Rate / Total Tank Volume
- Should Allow for Comparison of Data with Different Parameters, Regardless of Volume Flow Rate

## Slide 7

## Slide 8

## Nondimensional Oxygen Concentration

- Want to Express [O2] in Terms of Purity Delivered.  Consider that Gas is Slowly Changing the Ullage to Gas Purity
- Tank Inertion Ratio =                                   Air[O2] - Tank[O2]  /  Air[O2] - NEA[O2]
- Should Allow for Comparison of Data with Different Parameters, Regardless of Purity

## Slide 10

## Comparison of Data with Solutions

- Empirical Equation (fourth order polynomial) Based on Previous Graph
- ANM-100 Model (Ivor Thomas)
- Based on O2 Volume Exchange
- Gives One Nondimensional Solution
- Exact Solution Based on Perfect Mixing Model (y = 1 - e-λt )
- Results Compare Well

## Slide 12

## Slide 13

## Effects of Ullage Temperature / [THC]

- Performed Several Tests Varying Tank Ullage Temperature and Total Hydrocarbon Concentration
- Used Hot Plate Element, Kerosene Heater, and Liquid CO2
- Final Results Show Little Effect on Time to Inert

## Slide 15

## Slide 16

## Future Work

- Continue with Re-circulate and Replace Work and Quantify Benefit
- Extrapolate Requirements for an On-Aircraft System and Determine Preliminary Cost/Ben
- Work with Manufacturers to Develop Innovative Designs to Cut Cost/Weight/Size
# Presentation: 514306

## Figure (picture) 

**PI: ****	****Individual ****	****	*****Organization / State***
- Team:	Individual 		*Organization/ State*
- 	Individual 		*Organization* */ State*
- 	Individual 		*Organization / State*
- 	Individual 		*Organization / State*

*Figure (picture) *
*if applicable*

*Figure (diagram) or Table*
*2 levels of Indenture*

**$ TBD M**

**$ TBD M**

- TBD

**APPENDIX E.**

- Date	Deliverable
- Date	Deliverable
- Date	Deliverable
- Date	Deliverable
*Etc.*

## TBD
# Presentation: 741379

**Simulation of MEMS for the****Next Generation Space Telescope****FEMCI Workshop 2001**
**May 16-17**
**Presented by:**
**Brent Mott**
**Detector Systems Branch/Code 553**
**Goddard Space Flight Center**
**Greenbelt, Maryland 20771**
**For:**

-   **Jonathan Kuhn**
**Sowilo Networks**
**Columbia, Maryland**

**James Loughlin**
**Mechanical Systems Analysis & Simulation Branch/Code 542**
**Goddard Space Flight Center**
**Greenbelt, Maryland**

## Next Generation Space Telescope (NGST)

**8 m primary mirror**
**0.6-27 μm wavelength range**
**2009 launch**
**5 year mission life (10 year goal)**
**Passively cooled to <50K**
**L2 orbit**
**3 core instruments:**
**0.6-5 μm camera**
**1-5 μm Multi-object Spectrometer (MOS)**
**5-27 μm camera/spectrometer**

**See: **_[http://](http://mems.gsfc.nasa.gov/workshop/presentations/matt_greenhouse.pdf)__[mems](http://mems.gsfc.nasa.gov/workshop/presentations/matt_greenhouse.pdf)__[.](http://mems.gsfc.nasa.gov/workshop/presentations/matt_greenhouse.pdf)__[gsfc](http://mems.gsfc.nasa.gov/workshop/presentations/matt_greenhouse.pdf)__[.](http://mems.gsfc.nasa.gov/workshop/presentations/matt_greenhouse.pdf)__[nasa](http://mems.gsfc.nasa.gov/workshop/presentations/matt_greenhouse.pdf)__[.](http://mems.gsfc.nasa.gov/workshop/presentations/matt_greenhouse.pdf)__[gov](http://mems.gsfc.nasa.gov/workshop/presentations/matt_greenhouse.pdf)__[/workshop/presentations/matt_greenhouse.](http://mems.gsfc.nasa.gov/workshop/presentations/matt_greenhouse.pdf)__[pdf](http://mems.gsfc.nasa.gov/workshop/presentations/matt_greenhouse.pdf)_

## MEMS Aperture Masks

**MEMS Aperture Masks**

**Application: Multi-object spectrometer**

**MEMS Tunable Filters**

**Application: Wide field camera**

**Micro-shutter arrays**

**Micro-mirror arrays**

**Fabry-Perot interferometer**

**Electrostatic actuation**

## Electrostatic Actuation

## Coupled Electro-mechanical Response

- Static equilibrium:

- Unstable pull-in voltage:

- Dynamic response:

## Slide 6

## Slide 7

## Slide 8

## Electrostatic Actuation

**Electrostatic Actuation**

**Micro-shutter motion**

**Electrostatic field intensity**

## Slide 10

## Slide 11

## Slide 12

## Electrostatic Actuation

**Electrostatic Actuation**

## Slide 14

## Slide 15

## Slide 16

## Electromechanical Simulation - Recap

**Goals:**
**Predict performance**
**Predict reliability**
**Optimize design**
**Prevent failures**
**Challenges:**
**Large non-linear deformations**
**Complex surface contact**
**Coupled electromechanical interactions**
**Severe thermal mismatch**

**Environment:**
**Ground handling**
**Launch**
**Space flight**
**Software Tools:**
**MSC/NASTRAN**
**IntelliSuite**
**ANSYS/Multiphysics**
**In-house code**
# Presentation: 212492

## Q0 Degradation of LANL 700-MHz =0.64 Elliptical

**Q****0**** Degradation of LANL 700-MHz ********=0.64 Elliptical**
**Cavities and ANL 340 MHz Spoke Cavities**** **

**T. Tajima********, K. C. D. Chan, R. L. Edwards, R. C. Gentzlinger, J. P. Kelley, F. L. Krawczyk, M. A. Madrid, D. I. Montoya, D. L. Schrage, A. H. Shapiro**

**Q****0**** – E****acc**** Curves of LANL Six 700-MHz, ********=0.64, 5-Cell Elliptical Cavities**

**Summary**

**Work Supported by the **
**US Department of Energy**

**Q Disease Tests on ANL 340 MHz ********=0.4 Spoke Cavity**

**Spoke cavity set on the cryostat insert**

**Temperature evolution when the cavity was held at an intermediate temperature.  Holding times for the first and second tests were 13 hours at 100 – 102 K and 86 hours at 100 – 142 K, respectively.**

**Q – E curves before and after the warm up to an intermediate temperature.  No degradation was observed.**

**Summary of BCS and Residual Resistances of Elliptical and Spoke Cavities**

**Effect of External Magnetic Field on Surface Resistance**

**R****s**** vs. 1/T curve of the Sylvia cavity.  Shown at the top are the fitting results to get constants and R****res****.**

-  Q0 drop of LANL elliptical cavities starting at 8- 10 MV/m may be related to multipacting.
-  The sensitivity of surface resistance to external magnetic field was measured to be 0.22 n/mG.
-  Residual resistance of LANL elliptical cavities was measured to be 5.0 – 7.6 n
- Residual resistance of ANL =0.29 spoke cavity showed 8.5 n.
- Q0 disease tests on ANL 340-MHz spoke cavity showed no degradation.

- Note: =0.4 spoke cavity was measured after vacuum leaks and excessive baking.

- LANL Cavities

- Saclay multipactor-free cavity

- (Courtesy of H. Safa)

- Electrons &
- Power limit
# Presentation: 849622

## Picture

**INNOVATION**
- Produced a superconducting analog to digital
- converter for radio astronomy applications

**Superconducting DigitizerFor Radio Astronomy **

**S**mall
**B**usiness
**I**nnovation
**R**esearch

- JPL 93 Phase II

**Hypres, Inc.**

- Elmsford, NY

**ACCOMPLISHMENTS**
- Demonstrated a 10 GHz 2-bit digitizer for
-          radio  astronomy
-  Technology provides high sensitivity analog
-          to digital conversion, at very low levels of
-          power  consumption
-  High efficiency allows placement behind sensor
-          array in cryogenic environment
**COMMERCIALIZATION**
-  Received a $1.5 million contract with the
-          Navy to develop technology for a very sensitive,
-         high performance radar

**GOVERNMENT/ SCIENCE APPLICATIONS**
-  Radio astronomy and space deployed telescopes operating in the
-          x-ray and ultraviolet range of the spectrum

***40 Meter Radio Telescope at Owens Valley Radio Observatory Near Bishop, CA***

- 1993 Phase II; NAS7-1371
- NASA/JPL Contact - Rob McGrath
- Company Contact - Oleg Mukhanou

- Jet Propulsion Laboratory
- Success Story #7-028
# Presentation: 248198

## Beams Week in Review

- Successes
- Accumulator Shot Lattice
- Tevatron Longitudinal damper
- Pbars to Recycler again
- Tevatron apertures opened and orbit smoothed
- Stacking record

- All Experimenters Meeting

## Beams Week in Review

- Some detours
- Tevatron low beta orbit excursions
- Lost stores
- Raccoon glitches
- MI quadrupole failure

- All Experimenters Meeting

## Initial Luminosity

- All Experimenters Meeting

## Protons to Collision

- All Experimenters Meeting

## Pbars to Collision

- All Experimenters Meeting

## Store Summary

| Store # | Initial Luminosity | Duration | Termination | comments |
| --- | --- | --- | --- | --- |
| 1530 | 14.09 E30 | 20.7 hours | intentional | TRF4 trip |
| 1563 | 16.26 E30 | 3.2 hours | KRS glitch | new Accumulator Shot lattice; Tevatron longitudinal damper |
| 1565 | 15.04 E30 | 27.2 hours | Intentional | new Accumulator Shot lattice; Tevatron longitudinal damper |

- All Experimenters Meeting

## Peak Luminosity

- All Experimenters Meeting

## Integrated Luminosity

- All Experimenters Meeting

## Tevatron Summary

- Orbit Smoothing
- A0 aperture optimization
- Smoothing up ramp
- Low beta squeeze not completely satisfactory
- Lost shots/Recovery

- All Experimenters Meeting

## Tevatron Summary

- Lost shots/Recovery
- Chromaticities reduced from 153 – 200 GeV before store 1526
- All okay for 1526 - 1530
- Orbit smoothing
- Stores 1554 and 1556 aborted by A11 quench
- Smoothing (aperture) or instabilities?
- Round-the clock investigation
- Store 1563 and beyond
- Chromaticities restored
- Helices reduced by 10%

- All Experimenters Meeting

## Tevatron Summary

- All Experimenters Meeting

## Tevatron Summary – Orbit smoothing

- Store 1526

- Store 1565

- All Experimenters Meeting

## Pbar Summary

- Core cooling isolators installed
- Horizontal Bands 2 & 3 only
- Shot lattice put into operation

- All Experimenters Meeting

## Pbar Summary – Shot Lattice

- All Experimenters Meeting

## Pbar Summary – Shot LAttice

- All Experimenters Meeting

## MI Summary

- Low Emittance (8 GeV) proton Coalescing
- MI8 line Micado – scaling issues
- Pbar feedforward compensation

- All Experimenters Meeting

## Recycler Summary

- Pbars are back
- Aperture measurements

- All Experimenters Meeting

## Schedule for this Week

- Collider operation

- All Experimenters Meeting

## Schedule for this Week

- All Experimenters Meeting
# Presentation: 150264

## Reduce Firearm Related Injuries on the Tohono O’Odham Indian Reservation Through the Distribution of Gun Safes

- George Hupp, RN, BSN, PHN

## Purpose

- Restrict unauthorized access to firearms in the home.

## Background

- The illegal use of firearms has been reported in several incidents on the reservation
- Incidents involved firearms that were illegally obtained.

## Location

- The Tohono O’Odham reservation is located in Southeast Arizona covering 75 miles of the US and Mexico border.

## U.S.- Mexico Border

## Methods

- Tohono O’Odham police reports
- CDC Injury Prevention data
- Door to Door survey
- Education presented at health fairs

## Logistics

- Funds obtained from Tucson Area Division of Environmental Health and Engineering, Injury Prevention
- Purchased 20 gun safes from Cabela’s
- Safes arrived unassembled
- Assembly averaged 45 minutes per safe

## Ready for Distribution

- Safes were transported 5 at a time via pick up truck to the gun owner’s home
- The safe was placed inside the home and all firearms were properly stored at time of visit

## Focus on Long guns instead of Handguns

- Handguns are used for home defense and the owners prefer to have their weapons in close reach and easily accessible
- Handguns can be stored out of sight, out of reach children by much simpler means

- Handgun specific storage units are expensive
- Type of storage units preferred use simple touch combinations or fingerprint recognition
- These units price between $400 - $700

- Owner rational to use these types units is because less expensive units require number combinations or keys.  Under duress of a home evasion it would be difficult to remember a lengthy combination or to use a key to unlock a small storage unit.

## Trigger Locks 

- Tohono O’Odham Police Department has a trigger lock distribution program that has not been very popular
- Gun owners are hesitant about going to the police to ask for the trigger locks
- Trigger locks do render the firearm temporarily inoperable but do not prevent them from being stolen

- Trigger locks require the use of a small key to remove
-  It would be likely that the owner would fumble with the key under duress which would give the attacker time to forcibly overcome the owner

## PHN Role in Firearm Safety

- As Public Health Nurse I have the unique opportunity to visit tribal members in their homes and around the community and establish a good rapport
- Home visits not only cover health teaching but also home safety assessments
- The home safety assessments allowed me to inquire about safe firearm storage

## Follow up

- 10 safes have been distributed
- Follow-up visits were made to 6 recipients of the gun safes
- Of those 6, 100% continue to store their firearms in the safe, and are satisfied with the product and plan to continue their use of the safe

## Plans

- Research more funding sources
- Obtain additional gun safes
- Keep the project going
# Presentation: 788033

## Infrared Active Open-Path Spectroscopy to Measure Chemical Agentsand Hazardous Air Pollutants

**Robert H. Kagann****Spectral Solutions**2895 Bordeaux BlvdCumming, GA 30041

- Spectral
-      Solutions

##  Homeland Security:The Chemical Threat

- Chemical Warfare Agents (CWAs)
- Threat: rogue nations and terrorist groups have been stockpiling Chemical Warfare Agents
- Toxic Industrial Chemicals (TICs)
- Threat:  terrorists could sabotage the present chemical infrastructure to produce large-scale exposure of the homeland community to Toxic Industrial Chemicals

##  OP-FTIR Measurement Configuration

## FTIR Air-Measurement Technologies: Open-Path and Extractive

- Both
- Open-Path
- Extractive

- Identify/Quantify most ChemicalsReal-Time

- _Technology_

- _Advantage_

- Large-scale continuous spatial coverage
-  In-Situ
-  Remote
-  Tomography:
- Source Characterization
- Plume-Concentration Maps

- Point Measurement at Vulnerable Location (e.g. Air Intake of Buildings)

## Monitoring at a Chemical Spill(Scotts Bluff R.R. Accident)

## Tomographic Monitoring Scenario at Chemical Accident

## Tomographic Monitoring Scenario at Chemical Accident

##  IR Spectra of 7 CWAs Open-Path FTIR

- GA

- GB

- GD

- GF

- HD

- Lewisite

- VX

- Atmosphere

## Open-Path FTIR Detection Limits for Chemical Warfare Agents

##  Comparison of Measured Spectrum to GD reference

- GD Reference

- Measured Spectrum

##  Comparison of IR Spectrum of Triethyl Phosphate to Agent GD

- CWA Simulant TEP

- CW Agent GD

- Atmosphere

## Field Release Configuration

##  Field Release of CWA SimulantTriethyl Phosphate

## Open-Path FTIR Measurements of CWA-Simulant Field Releases

## Open-Path FTIRDefense Applications

- Remediation Monitor – Emergency Response
- Chem Decom
- Facility Closures
- Chemical Agent Stockpile Monitor
- Safety
- Military Facility Perimeter Monitors
- Protection against chemical attack
- Ground Truth for field testing chemical monitors

## Fenceline Coverage of Chemical Facility in New York State

##  Open-Path Fenceline Installation in South Carolina Facility

## Conclusion

- Open Path FTIR:
- Ability to Monitor a Large Number of Chemicals in Real-Time
- Valuable Component of an Early Warning Response System to Chemical Attacks and Accidents
- Hazardous Levels of CWAs and TICs can be Reported in Seconds
- Continuously Monitor the Perimeter of Potential Targets for Release of CWAs and TICS
- Combine with Tomography
- Locate Emission Sources
- Determine Plume-Transport Direction For Community Evacuation Decisions

##  Proposed Perimeter Monitor at a Potential Chemical Target

##  Concentration-Rose Points to Emission Source
# Presentation: 744026

## QUESTIONS TO THE COMMITTEE

- 1.  Do data from the pivotal study provide substantial evidence of safety and efficacy of daptomycin in the treatment of *S. aureus* bacteremia?
- 	Please include in your deliberations a discussion of the significance of patients with persistent or relapsing bacteremias, and whose staphylococcal isolates had increasing MICs to daptomycin.
- 	a.  If your response is yes, are there specific comments that you have regarding the product label?
- 	b.  If your response is no what additional study or studies would you recommend?

**Center for Drug Evaluation and Research**
**Anti-Infective Drugs Advisory Committee**
**March 6, 2006**
**NDA 21-572/S-008**

##  QUESTIONS TO THE COMMITTEE (Continued)

- 2.  Do data from this study provide substantial evidence of safety and efficacy of daptomycin in the treatment of patients with infective endocarditis?
- Please include in your deliberations a discussion of whether the efficacy results in the all-comers population with *S. aureus* bacteremia can be extrapolated to the subgroup with infective endocarditis.

**Center for Drug Evaluation and Research**
**Anti-Infective Drugs Advisory Committee**
**March 6, 2006**
**NDA 21-572/S-008**

## QUESTIONS TO THE COMMITTEE(Continued)

- 3.  Do you recommend additional studies of daptomycin in the treatment of patients with *S. aureus* bacteremia, including infective endocarditis?
- 4.  What recommendations do you have for future studies of *S. aureus* bacteremia and endocarditis?
- Please include in your discussion study design issues such as case definition, specificity of diagnosis at baseline, inclusion and exclusion criteria, and endpoints.

**Center for Drug Evaluation and Research**
**Anti-Infective Drugs Advisory Committee**
**March 6, 2006**
**NDA 21-572/S-008**
# Presentation: 763469

## General Aviation Engine Management Predictive-Analysis System

**                               ****ACCOMPLISHMENTS**
-   Network of distributed engine sensors
-   Achieved FAA certification for the warning annunciation panel
**                              ****COMMERCIALIZATION**
-   Partnerships created with major airplane retrofitter - Mod Works
-   Over 1000 systems sold to GA customers
-   Sales to date $1,250,000
-   Two full time engineering and 2 productions jobs created

**General Aviation Engine Management Predictive-Analysis System**

***Vision Micro Design***
***Bellingham, WA***

**S****mall**
**B****usiness**
**I****nnovation **
**R****esearch**

**      ****GOVERNMENT/SCIENCE APPLICATIONS**
**  **Low cost engine monitoring technology is one of the 		major thrust areas of the NASA AGATE program and is 	considered a vital element for GA revitalization
- 	The HFE technology creates a reduction in pilot work 	load and thus impacts safety

- 1993 Phase II
- NASA Contact - Henry Jarrett  (757)864-1917
- Company Contact - Cathy Turk  (360)714-8203

- Langley Research Center

**Engine Monitoring System & Annunciation Panel**

- Low cost, Intelligent engine health monitoring system for Small Airplanes
# Presentation: 668492

## The AQI and AIRNow:  Providing Knowledge, Protecting Health

| Air Quality Index Levels of Health Concern | Numerical Value | Meaning |
| --- | --- | --- |
| Good | 0-50  | Air quality is considered satisfactory, and air pollution poses little or no risk.  |
| Moderate | 51-100 | Air quality is acceptable; however, for some pollutants there may be a moderate health concern for a very small number of people who are unusually sensitive to air pollution.  |
| Unhealthy for Sensitive Groups | 101-150 | Members of sensitive groups may experience health effects. The general public is not likely to be affected.  |
| Unhealthy | 151-200 | Everyone may begin to experience health effects; members of sensitive groups may experience more serious health effects.  |
| Very Unhealthy | 201-300 | Health alert: everyone may experience more serious health effects.  |
# Presentation: 351038

## Classical H2 Cycling Model

**Classical H****2 ****Cycling Model**

**During oxidation of organic acids, hydrogen cycling has been proposed to occur whereby the reducing equivalents and protons produced (2H+ + 2e-) are substrates for cytoplasmic membrane bound hydrogenases which generate hydrogen that then diffuses into the periplasm.  Periplasmic hydrogenases oxidize the hydrogen and the electrons are recaptured by the *****c*****-type cytochromes and ultimately return to the cytoplasm for use in sulfate reduction.  The protons left contribute to the proton gradient which drives ATP synthesis, membrane, then use for sulfate reduction.**

## Classical H2 Cycling Model

**cytochrome *****c*****3****·red + H****+**

**ATPase**

**FeHase**

**LDH**

**H+**

**Lactate**

**Pyruvate**

**Acetate**

**e-**

**2e-**** ****+ 2H+**

**NiFeHase**

**Sulfate reduction!**

**Periplasm**

**ATP**

**H****2**

**ADP + P****i**

**ATP**

**ADP + P****i**

**Classical H****2 ****Cycling Model**

**Trans-**
**Membrane**
**Complex**

**2e-**** ****+ ****2H+**

**CytoplasmicHases**

**H****2**

## Alternative H2 Cycling Model

**Alternative H****2 ****Cycling Model**

**Lactate is oxidized by the membrane-bound lactate dehydrogenase (LDH) passing electrons to the putative pool of menaquinone (MK).  MK picks up cytoplasmic protons upon reduction and delivers them to the periplasm while delivering electrons to a carrier such as the quinone-interacting membrane bound oxidoreductase (QMO)  Pyruvate oxidation may result in delivery of electrons to a transmembrane complex that pumps protons to the periplasmic face of the cytoplasmic membrane.  There tetraheme cytochrome *****c*****3***** *****accepts the electrons and simultaneously becomes protonated.  If cyt*****c*****3 cannot be oxidized by HMC rapidly enough, H2 will be generated and subsequently cycled by the NiFe Hase.  Cytochrome *****c*****3 is proposed to deliver e- to HMC (or another transmembrane conduit) and H+ to the ATPase.  Thus no free proton gradient need be established****.**

## Alternative H2 Cycling Model

**cytochrome *****c*****3****·red + H****+**

**HMC**
**Complex**

**ATPase**

**FeHase**

**LDH**

**QMO**

**APS reductase**

**H+**

**H****2**

**H+**

**H+**

**e-**

**MK**

**Lactate**

**Pyruvate**

**Acetate**

**e-**

**2e-**** ****+ 2H+**

**NiFeHase**

**Sulfate reduction**

**Periplasm**

**ATP**

**H****2**

**ADP + P****i**

**ATP**

**ADP + P****i**

**Alternative H****2 ****Cycling Model**

**Trans-**
**Membrane**
**Complex**
# Presentation: 217421

## UPC Applications

**Parry Husbands**

## Roadmap

**Benchmark small applications and kernels**
**SPMV (for iterative linear/eigen solvers)**
**Multigrid**
**Develop sense of portable UPC programming style (using T3E and Compaq AlphaServer)**
**Motivate and evaluate compiler optimizations**
**Move to larger applications**
**Candidates should be hard with current techniques:****Large N-body problems****Sparse Direct Methods****3-D Mesh Generation****...**

## Sparse Matrix-Vector Multiplication

**Ax=b with A sparse**
**Distributed Compressed Row Format Used for A**
**Vectors distributed across processors**
**Communication of elements of x needed to compute b**

## Communication Strategies

**Need to send elements of x to processors that need them**
**Individual sends?**
**Pack?**
**Prefetch?**
**Try to overlap communication with computation**
**Initiate communication**
**Do some local computation**
**Wait for remote elements**
**Compute on remote elements**

## T3E Results

## Compaq Results (1)

## Compaq Results (2)

## Discussion

**Small message version required access to low latency messaging for performance**
**Manually done on T3E**
**Under investigation on Compaq**
**Pack/Unpack version gives best portable performance**
**Relies on large messages (usually best performing)**
**Requires more source code**
**Investigating inspector/executor techniques**
**Proposal**
**Make life easy for the compiler and add a pragma:****#pragma prefetch(vector,indices)**

## Multigrid

**Taken from NAS Parallel Benchmarks**
**Hierarchy of grids (256****3****->2****3****)**
**Project down to coarsest grid**
**Solve**
**Prolongate and smooth back up to finest grid**
**Operators all involve nearest neighbour computations in 3-d and ghost region exchanges**
**Code based on OpenMP version from RWCP**
**Simple domain decomposition scheme used to map 3-d grid to a 3-d processor grid.**
**On T3E computation compiled with CC (multidimensional array performance poor with gcc)**

## Data Structures

**For grid large, static distributed array not feasible**
**Difficult to change sizes at runtime**
**Need to access through local pointers for performance****(avoid A[i] for pointer to shared A)**
**Pointers to local regions (upc_local_alloc()’d) used instead**
**Can easily access any global element**
**Directory can be cached locally**

## T3E Results – Class B (2563)

## T3E Results – Class C (5123)

## Discussion

**Outperform MPI Fortran version on T3E!**
**Single processor performance an issue**
**No speedups past 8 processors on Compaq**
**Spins to signal incoming variables**
**May need to reorganize communication**
**No small message version yet.  Probably not worth it on Compaq.**
# Presentation: 276412

## Building Section 508 in your Agency

**Building Section 508 in your Agency**

## Five steps

**Awareness and Executive buy-in**
**Acquisitions Changes**
**Define Compliance**
**Training**
**Exception handling**

## Awareness and Executive buy-in

**Issue policy requiring PROACTIVE actions to implement 508**
**Add Section 508 metrics into SES performance template**
**Get CIO Office to include 508 in CPIC Reviews**
**Identify gatekeepers (contracting officers, webmasters, IT directors) that can ensure 508 is done.**

## Acquisitions Changes

**Mandate a PAT – nothing voluntary about it!**
**Make sure it is filled out to your agencies specifications**
**Make it a requirement for consideration of an offer**
**Put vendors on notice that any failure to meet the stated PAT must be remediated at no cost to the gov’t.**
**Require 508 in Acquisition Planning Documents**

## Acquisitions Changes

**Include 508 outputs in Life Cycle milestones**
**Make streamlined procedures for electronic documents**
**Not bought by IT-savvy programs**
**Not developed by accessibility experts**
**Generally doesn’t require a PAT**

## Define Compliance

**Include Access Board standards in Enterprise Architecture**
**Build checklists for the standards, showing how accessibility will be tested**
**Let contracts for testing – don’t make your people become experts in accessibility**
**Use specialized checklists for commonly-used technologies (e.g. PDF documents)**
**Make checklists public so vendors, staff, and the public know your requirements.**

## Training

**Make a “basic” course for staff**
**No more than 1 hour**
**Require attendance for COTR renewal, SES performance, and Credit Card renewal**
**Covers the “What”, not the “How”**
**Do short classes on Accessible electronic documents**
**How-to, as well as How-to-check**
**Do separate classes on formats (PPT, Word, PDF, etc)**

## Training

**Make an “Advanced” course for people who buy EIT on a regular basis.**
**As long as necessary**
**Required for:**
***IT Project Officers, ***
***BPA Administrators, ***
***Contracting Officers handling IT acquisitions***

## Exception handling

**Identify Senior Manager (SES) to authorize exceptions**
**Operational staff can request but not approve**
**Deny Undue Burden and severely limit National Security**
**Have audits on exception processing by an independent office (IG office, EEO Director, Etc.)**

## Building Section 508 in your Agency

**Building Section 508 in your Agency**
# Presentation: 351037

## Extinction Related Background 

| Source | Events |
| --- | --- |
|  decay in orbit | 0.25 |
| Tracking errors | < 0.006 |
| Radiative  capture  | < 0.005 |
| Beam e- | < 0.04 |
|  decay in flight |  0.04 |
| decay in flight | < 0.001 |
| Radiative capture | 0.07 |
| Anti-proton induced | 0.007 |
| Cosmic ray induced | 0.004 |
| Total Background | 0.45 |

- Estimated Backgrounds for nominal beam conditions and design sensitivity** **

**Degrading the extinction by a factor of 10 directly scales ALL of these background contributions by the same factor, meaning we go from ~ 1/2 background event to nearly 2 expected background events**
**Compare this to the 5 signal events we would observe for a putative signal at R********e****=10****-16**
**In short, we CANNOT relax the extinction requirement.**

- Michael Hebert, UC Irvine                    Status and Perspectives of MECO, the Muon to Electron Conversion Exp.

- June 10, 2003

## Proton Throughput 

| Source | Events |
| --- | --- |
|  decay in orbit | 0.25 |
| Tracking errors | < 0.006 |
| Radiative  capture  | < 0.005 |
| Beam e- | < 0.04 |
|  decay in flight |  0.04 |
| decay in flight | < 0.001 |
| Radiative capture | 0.07 |
| Anti-proton induced | 0.007 |
| Cosmic ray induced | 0.004 |
| Total Background | 0.45 |

- Estimated Backgrounds for nominal beam conditions and design sensitivity** **

- As stated yesterday we have a cosmic ray background that scales with exposure time
- A first look indicates that we are not background compromised by doubling the running time
- Of course, what we save in beam development up front we are likely to more than pay for in additional integrated running costs

- Michael Hebert, UC Irvine                    Status and Perspectives of MECO, the Muon to Electron Conversion Exp.

- June 10, 2003
# Presentation: 743628

## Loop Heat Pipe for High Density Small Satellite Thermal ControlThermacore, Inc.Lancaster, PA

**ACCOMPLISHMENTS**
- A bidisperse structure is used on the outer layer of the evaporator wick with several-micrometers pore size.
- Capillary forces provide fluid circulation for energy transfer.  This passive operation results in high reliability and long life.
- Long small-diameter transport lines with smooth inner walls offers design flexibility by transferring heat away to areas where dissipation is more convenient or airflow is greater. The lines can be bent and formed into a variety of configurations while maintaining their heat transfer capabilities.
- Cost effective in OEM production quantities. The long-term reliability and zero-maintenance contributes to a lower total applied cost of the loop heat pipe solution than other less-reliable cooling products.

**S****mall**
**B****usiness**
**I****nnovation**
**R****esearch**

- 1995 Phase II, SS5-043, 9/19/00

**COMMERCIALIZATION IN PROGRESS**
- Gravity-aided modifications of a high-heat-flux Loop Heat Pipe will be used in cooling systems for commercial server boards where CPUs dissipate up to 200 W each.
**GOVERNMENT SCIENCE/APPLICATIONS**
- The high-heat-flux Loop Heat Pipe is being tested at GSFC for satellite applications.

**Goddard Space Flight Center**

**INNOVATION**
- Improved high-heat-flux Loop Heat Pipe operating efficiency from 20 W/ cm2 to 100 W/cm2 on the evaporator wall.

- Points of Contact:
-   -  NASA - Greg Greer; 301-286-7295
-   -  Thermacore, Inc.; Dmitry Khrustalev 717-569-6551

***High-Heat-Flux Loop Heat Pipe***
# Presentation: 745116

## Discussion of Real Property Asset Management (RPAM) Order 

- Review of Key Changes from LCAM
**Presentation to the **
**SC Facilities Management Workshop **
**October 23-24, 2002**
- Steven H. Rossi, P.E.
- Laboratory Infrastructure Division
- Office of Science

## Objectives

**links real property asset planning, programming, budgeting and evaluation to program mission projections and performance outcomes****.**
**implements DOE P 580.1**

## Requirements Section

**Discussion on sustainment (2-4% of RPV) and recapitalization are included as well as long-term stewardship and performance objectives and criteria.**
**The results of the real property asset site planning and performance to be documented annually in a Ten-Year Site Plan (TYSP). **

## Requirements Section (cont.)

**TYSP will be consistent with the Integrated Facilities and Infrastructure (IFI) Crosscut Budget and the Department’s Planning, Programming, Budgeting, and Evaluation System (PPBES).**
**TYSP would be prepared in accordance with LPSO, CSO, and Program Secretarial Office (PSO) annual program direction and guidance for mission projections.**
**It would report on past performance and projected future outcomes and shall compare the budget authority against the actual expenditures and the performance outcomes.  **
**Condition assessments would be performed annually on a minimum of 20 percent of the plant and performed on all real property assets a minimum of once every five years.**

## Requirements Section (cont.)

**Asset Utilization Index    =     **_**current real property assets**_
**                  ****	****	****	****  ****utilization-justified assets**
** **
**Asset Condition Index =  1  -  Facility Condition Index (FCI) **

_**AUI Range**_**	****	**_**AUI Rating**_
**1.0    ≤   1.1****	****	****Excellent**
**1.11  ≤   1.2****	****	****Good**
**1.21  ≤   1.3****	****	****Adequate**
**1.31  ≤   1.5****	****	****Fair**
**1.51  ≤   1.75   ****	****Poor**
**         ****>   1.75****	****	****Failure**

** **
_**ACI Range**_**	****	**_**ACI Rating**_
**1.0 > .98****	****	****Excellent**
**.98 ≥ .95****	****	****Good**
**.95 ≥ .90****	****	****Adequate**
**.90 ≥ .75****	****	****Fair**
**.75 ≥ .40****	****	****Poor**
**      ****< .40****	****	****Failure**** **

## Interrelationships of those responsible for achieving the requirements of the Real Property Asset Management Order 

**Interrelationships of those responsible for achieving the requirements of the Real Property Asset Management Order**** **

## Slide 7
# Presentation: 432587

## 58th Annual Councils’Awards Ceremony

- Richard E. Fairfax, CIH
- Director, Enforcement Programs

## Directorate of Enforcement 	Programs	

- Office of General Industry Enforcement
- Office of Health Enforcement
- Office of Investigative Assistance
- Office of Maritime Assistance
- Office of Federal Agency Programs

## Office of Federal Agency 	Programs

***Agency Support:***
- Presentations
- Technical Assistance
- Outreach
- Training

## Office of Federal Agency 	Programs

***Council Activities:***
- Manual
- Charters
- Website
- Training Conference

## Federal Agency Inspection Data

## Inspections Conducted

## Inspection By Type% Programmed vs. % Unprogrammed

## Total Violations Issued

## % Violations Issued As Serious,Willful, Repeat, FTA

## % Inspections With Violations

## FY 2000 - FY 2003 (Combined)Most Frequently Cited Standards

| 1. | Electrical, Wiring Methods |
| --- | --- |
| 2. | Hazard Communication |
| 3. | Electrical, Systems Design |
| 4. | Means of Egress |
| 5. | Bloodborne Pathogens |
| 6. | Portable Fire Extinguishers |
| 7. | Walking-Working Surfaces |
| 8. | Respiratory Protection |
| 9. | Machine Guarding |
| 10. | Guarding Floor & Wall Openings |

## Federal Worker 2000 Presidential Initiative

## FED 2000 Goals

- Reduce injuries by 3% per year & improve timeliness by 5% per year
- Reduce injuries by 10% at sites with highest incidence rates
- Reduce lost production day rates by 2% per year

## Federal Initiatives

- SHARE ’04
- Recordkeeping Changes

## 58th Annual Councils’Awards Ceremony
# Presentation: 312154

## Modeling glacial stagnation vs. glacial retreatWAIS 2004

- David Vacco
- Richard Alley
- David Pollard
- Todd Dupont
- Byron Parizek

- Department of Geosciences
- Pennsylvania State University
- State College, PA 16802

## Goals 

- Define the problem
- Present results to date
- Future work

## Slide 3

## Slide 4

## Glaciers typically lose mass by retreating

**Ice flow**

- Rising ELA over time

**A(t,x)**

## Approach: Small hypotheses

- Small, Eric E., 1995, Hypsometric forcing
-      Of stagnant ice margins: Pleistocene valley
-      Glaciers, San Juan Mountains, Colorado.
-      *Geomorphology* **14**, p. 109-121.

- Stagnation occurs when melt-back does not
- Keep up with rapid thinning

- Valley hypsometry is the dominant control
- on the mass loss mechanism

## Stagnation scenario: topographic control (Small, 1995)

## Stagnation Scenario: hypsometric control (Small, 1995)

**Raise in ELA**

## Mass conservation

Find steady state profiles for sinusoidal beds

Induce a warming

- Find steady state profiles for sinusoidal beds
- Induce a warming

- First modeling efforts

## Example profile

- 0

- 1000

- 0

- 20

- 10

- Distance, km

- Height, m

- Shift the bed

## Steady state Terminus behavior

**X**

**X**

- The terminus likes
- to hang out here

- Doesn’t like to
- hang out here

**X**

**X**

**X**

**X**

**X**

**X**

- Mean slope

## Stagnation vs. retreat

- 60

- 40

- 20

- 2000

- 4000

- 6000

- 50

- 30

- 10

- 3000

- 5000

- Bed wavelength, m

- Bed amplitude, m

**STAGNATES**

**RETREATS**

## Stagnation vs. retreat

- 60

- 40

- 20

- 2000

- 4000

- 6000

- 50

- 30

- 10

- 3000

- 5000

- Bed amplitude, m

- Bed wavelength, m

**STAGNATES**

**RETREATS**

## Future work

- 2-d and 3-d models
- Add longitudinal stresses
- Subglacial water
- Dynamic beds (FEM)
- Analytical modeling using perturbation methods, etc...

## Questions, comments?
# Presentation: 114770

## Integrated Luminosity

- All Experimenters Meeting

## Peak Luminosity

- All Experimenters Meeting

## Initial Luminosity

- All Experimenters Meeting

## Protons to Collision

- All Experimenters Meeting

## Pbars to Collision

- All Experimenters Meeting

## Tevatron Studies Summary

- F11 bake
- 150 GeV lifetime
- Octupole study
- stabilize beam w.low chromaticity
- Experimental support
- proton only stores

- All Experimenters Meeting

## Tevatron Studies Summary

- All Experimenters Meeting

## Tevatron Studies Summary

- Measured Vertical Emittance
- 32	A1-4
-   12 	A13-16
-   18	A25-28

- MI Hor Scraped Emittance
- ?	A1-4
-   9 	A13-16
- 12.3	A25-28

- All Experimenters Meeting

## Pbar Studies Summary

- More IBS studies
- Transverse thermostat

- All Experimenters Meeting

## Pbar Studies Summary

- New lattice IBS studies – previous week
- Pbar stack moved to central orbit
- change the lattice
- compare heating rates
- Conclusions – previous week
- The 4-D and 6-D phase space products showed almost a factor of 3 lower emittance and growth rate
- The initial conditions between the current lattice and the study lattice were not the same, another study needed

- All Experimenters Meeting

## Pbar Studies Summary

- New lattice IBS studies – this week
- Pbar stack moved to central orbit
- change the lattice
- compare heating rates
- Conclusions – this week
- Effect of IBS less conclusive
- Modeling
- More study time

- All Experimenters Meeting

## Pbar Studies Summary

**Transverse Heating Rates**

- All Experimenters Meeting

## Pbar Studies Summary

- All Experimenters Meeting

## Pbar Studies Summary

- All Experimenters Meeting

## MI Studies Summary

- Beam loading compensation
- Longitudinal emittance

- All Experimenters Meeting

## MI Studies Summary

- Applied feed forward beam loading compensation on two RF stations (stations1, 2) by using the same up-convert/down-convert module and the fan-out cables from the MI-60 control room.
- All the parts needed to modify the rest of the rf stations have been received.
- It is estimated that will take 8-10 hours to modify the rest of the 16 RF stations.

- All Experimenters Meeting

## MI Studies Summary

- All Experimenters Meeting

## Recycler Studies Summary

- All Experimenters Meeting