# Presentation: 147162

## SBRP- ORD Research Collaboration in Action

- William A. Suk
- Director, SBRP
- National Institute of
- Environmental Health Sciences
- National Institutes of Health
- Department of Health and Human Services
** **

- December 14, 2005

- Cincinnati Ohio

## Objectives

- Briefly describe the Superfund Basic Research Program and indicate the types of research it supports
- Compare SBRP and ORD research
- 	approaches
- Identify SBRP and ORD research coordination efforts

**Notes:**
In addition to getting to know you, we hope to accomplish two objectives today – 
	(1) Introduce the types of research results and services that are coming out of the NIEHS and EPA research programs, 	
	(2) Encourage feedback on and interest in the application of these research efforts

We have a display and many handouts!

## SBRP: Mission Statement

***Brief History***

**SBRP: Mission Statement**

- Established in 1986 under SARA
- Basic Research
- University-based  grants program
- Intended to complement EPA and ATSDR
-  Includes training, outreach, partnering, tech. transfer

## SBRP Research

-   20 multi-project grants
-   ~600 investigators
-   ~200 graduate students
-   $50M budget
-   Focus on interdisciplinary research –   	crossing 	traditional science boundaries

## SBRP Grantees

- U of Kentucky

- Michigan State U

- U of Cincinnati

- Dartmouth
- Boston U
- Harvard
- Brown U
- New York U
- Mount Sinai
- Columbia U
- Duke U
- U of NC
- U of Florida

- Texas A & M

- U of Washington
- Oregon Health Sciences U
- U of CA – Davis
- U of CA – Berkeley
- U of CA-San Diego
- U of Arizona

**Notes:**

Re the SBRP 
Again you can consider all of the SBRP investigators to be a resource to you. Also as Beth mentioned there is point of contact in each program  responsible for interfacing with stakeholders (Research Translation Core Leader). We have a hand out listing the programs and the principal investigators.

## Interdisciplinary Research for Improving Public Health

* *Using* *biomarkers in wildlife as
- risk assessment tools. Incorporating uptake studies and metabolic profiles to identify and evaluate remediation strategies.
*	**Mike Hooper - U. of Washington*

-  Examining influence of groundwater arsenic mobilization and bioavailability on human exposures which ultimately can lead to disease.
*	**Joe Graziano – Columbia U . *

* *By incorporating a basic mechanistic understanding of benzene metabolism, developed biomarkers of exposure and related them to increased occurrence  of leukemia in clothing factory workers.
*	**Martyn Smith - U.C. Berkeley*

## Research Topics of Interest to the SBRP

- Understanding the relationship between exposure to hazardous substances and human health
- Impacts of hazardous substances on ecosystems
- Strategies to understand the physical, chemical and biological processes affecting chemicals in environmental media
- Methods and approaches to effectively reduce the amount and toxicity of hazardous substances.

*Almost any aspect of scientific and intellectual inquiry and methodology that are directly related to:*

**Research Topics of Interest to the SBRP**

## Planning and Priority Setting

- Input from scientific community (through workshops)
- Input from partners
-      (EPA, ATSDR, States, Community)
- Joint participation in national research meetings
- Relevancy considerations

**Planning and Priority Setting**

## SBRP: The Ingredients

**Partnerships**

**SBIR/STTR**

**Research **

**Translation**

**Conferences**

**Research**

**Outreach**

**Training**

**Communications**

**Advance the Infrastructure of Environmental Health**

**SBRP: The Ingredients**

## Two Research Programs:

- With Real World Orientations!

-  **Applied**
** ****problem driven**
-  National Laboratories
-  intramural
-  Environmental Sciences
-  Technical Support Centers 	and Regional Liaisons

-  **Basic**
** ****longer term goals**
-  U.S. Universities
-  extramural: competitively awarded grants
-  Human health focus, plus    	environmental sciences
-  Research translation and 	outreach

**Notes:**
Thank you Larry
I am going to briefly run through the two programs
While we both support research, we have each carved out different pieces of the pie
Important : we work together, coordinate with the goal of improving research translation and providing you and other stakeholders with resources you can use.

First in the research continuum from the most basic to the most applied  - SBRP falls on the Basic side and ORD on the applied – next slide

## Basic vs. Applied

- Research Continuum

- Basic

- Applied

**Notes:**
Clearly an over simplified diagram to depict that
An underlying difference between the two programs

ORD’s research is problem driven – finding solutions for immediate needs, where as the SBRP is charged with supporting the science to meet long term needs.
The division between the two programs is not absolute, we have flexibility

## Two Research Programs:

- With Real World Orientations!

-  Applied
-  problem driven
-  **National Laboratories**
** ****intramural**
-  Environmental sciences
-  Technical Support Centers 	and Regional Liaisons

-  Basic
-  longer term goals
** ****U.S. Universities**
** ****extramural: competitively awarded grants**
-  Human health focus, plus    	environmental sciences
-  Research translation and 	outreach

**Notes:**
From a mechanistic, administrative approach the programs are different. 

National Labs – are topic specific (for example – NCEA, NHERL, NNERL)  located across the country
Larry/Randy: How is research selected – how do they know what type of research is needed. How do they decide what to do?

SBRP – research is a grants program  conducted at universities – there are currently 20. 

## Two Research Programs:

- With Real World Orientations!

-  Applied
-  problem driven
-  National Laboratories
-  intramural
-  **Environmental sciences**
-  Technical Support Centers	and Regional Liaisons

-  Basic
-  longer term goals
-  U.S. Universities
-  extramural: competitively awarded grants
-  **Human health focus, plus    ****	****environmental sciences**
-  Research translation and 	outreach

**Notes:**
ORD has a strong focus on Environmental Science, where as the SBRP has a strong emphasis on human health

## Two Research Programs:

-  Basic
-  longer term goals
-  U.S. Universities
-  extramural: competitively awarded grants
-  Human health focus, plus    	environmental sciences
** ****Research translation and ****	****outreach**

-  Applied
-  problem driven
-  National Laboratories
-  intramural
-  Environmental sciences
** ****Technical Support Centers   ****	****and Regional Liaisons**

- With Real World Orientations!

**Notes:**
Last bullet describes the structure that each program uses to serve as a resource to you.
with in ORD technical support centers have been established to provide site specific assistance
And within each region there is technical assistance available

Within each SBRP grant there is a Research Translation Core – and one of its function is to be  a liaison EPA, the states and tribes.

Now – turn it over to Randy...

## 
Memorandum of Understanding - To improve collaborations and coordination between ORD and the SBRP

Meet annually
Identify research ready for transfer from lab to demonstration
Seek opportunities to co-sponsor research conferences
Share research plans (e.g. multi- year plan)
Exchange research findings

*Memorandum of Understanding - To improve collaborations and coordination between ORD and the SBRP*
*Meet annually*
*Identify research ready for transfer from lab to demonstration*
*Seek opportunities to co-sponsor research conferences*
*Share research plans (e.g. multi- year plan)*
*Exchange research findings*

**On-Going Collaborations:**

## 

Coordination of research agendas to enhance complementary, cooperative research

- Coordination of research agendas to enhance complementary, cooperative research

**On-Going Collaborations:**

## NIH Peer-Review Grant Award Process

**NIH Peer-Review Grant Award Process**

**Mandates**

**Concept**** ****Reviewed by NAEHS Council**

**Develop & release RFA**

**Peer Review of Applications**

**2****nd**** level review**
**NAEHS Council**

**EPA and ATSDR Ad Hoc members**

**NIEHS staff meet with EPA  (and ATSDR)**
** ****Headquarters – e.g. ORD, OSRTI**
** ****Region – e.g. RA, HSTLs**

**EPA staff**
** ****Reviewers – e.g. ORD**
** ****Observers – e.g. OSRTI**

**Discussion with EPA staff**
**	****e.g. ORD and OSRTI**

**EPA and ATSDR Ad Hoc members**

- Grant Award*!!!*

## NIH Peer-Review Grant Award Process

**NIH Peer-Review Grant Award Process**

**Mandates**

**Concept**** ****Reviewed by NAEHS Council**

**Develop & release RFA**

**Peer Review of Applications**

**2****nd**** level review**
**NAEHS Council**

**EPA and ATSDR Ad Hoc members**

**NIEHS staff meet with EPA  (and ATSDR)**
** ****Headquarters – e.g. ORD, OSRTI**
** ****Region – e.g. RA, HSTLs**

**EPA staff**
** ****Reviewers – e.g. ORD**
** ****Observers – e.g. OSRTI**

**Discussion with EPA staff**
**	****e.g. ORD and OSRTI**

**EPA and ATSDR Ad Hoc members**

- Grant Award*!!!*

*Priority and relevance*

## Arsenic Residuals Project

Investigation of potential public health implications of landfill disposal of arsenic-bearing solid residuals from municipal water treatment

Collaborative project involving SBRP staff, SBRP-funded researchers, ORD, OSW, OW and OSRTI 

Ongoing discussions via conference calls and meetings

ORD Center for Exposure Assessment Modeling staff  and SBRP are using ORD risk assessment models  to quantify impact

Two additional conferences are planned for 2006

*Investigation of potential public health implications of landfill disposal of arsenic-bearing solid residuals from municipal water treatment*
*Collaborative project involving SBRP staff, SBRP-funded researchers, ORD, OSW, OW and OSRTI *
*Ongoing discussions via conference calls and meetings*
*ORD Center for Exposure Assessment Modeling staff  and SBRP are using ORD risk assessment models  to quantify impact*
*Two additional conferences are planned for 2006*

**On-Going Collaborations:**

## Risk-e-Learning seminar series
Ongoing DNAPL series

 Joint funding of domestic and international conferences

*Ongoing DNAPL series*
* **Joint funding of domestic and international conferences*

**On-Going Collaborations:**

## Tools ORD can use:

** ****Research Briefs**
** ****Risk E-learning**
** ****Peer Reviewed Publications**
** ****Site Specific Applications**
** ****Scientific Expertise**
** ****Grantees**
** ****Web Page**

**Notes:**

SBRP has implemented several tools to make the research findings more accessible
Research Briefs are an electronic distributions of research findings – disseminated monthly
They are a quick read with follow up references.

Risk E Learning is a web based seminar series. SBRP brings in different investigators both  SBRP and others to discuss hot topics
The next series will begin late this summer and will be about DNAPls

Of course, all investigators are encouraged to publish and the Program produces about 500 pubs per year.

Although the SBRP is not a site specific program, it does conduct some site specific work – I think you can gloss over this point...

Scientific Expertise – There is a wide array of scientific expertise within the SBRP that you can consider a resource. (you can kind of sweep over this and go into more detail next slide)

Web pages – self explanatory... 
By the way I have added a slide at the end with Web addresses

## Health Outcomes: Protection of Human Health and the Environment

- 	routes of exposure
- 	effects of exposure
- 	*prevention* of exposure

*Reduce uncertainty of risk*
*Contribute to decision making*

## Check us out!!!

- SBRP: http://www.niehs.nih.gov/sbrp/

*Our Web page:*

**Notes:**
We want to be a resource to you.