BEE-spoke-data/govdocs1-by-extension huggingface dataset:
# Presentation: 063383

## University of Minnesota MRSEC Nuggets – 2005Lodge T. P. DMR-0212302 (IRG 2) Thin Film Transistors Based on Hybrid Oligoacene/Thiophene Molecules

- In collaboration with 3M scientists, graduate students Jeff Merlo, Chris Newman, and Sandy Fritz, working with Frisbie, have made and characterized a new class of organic semiconductor materials that have improved stability relative to pentacene, the benchmark material. Figure 1 shows the structure of the anthracene-bithiophene-anthracene material synthesized at 3M that is representative of a class of similar molecules. The An-2T-An material forms beautiful films and has very good transistor characteristics, as shown. However, the key finding is that this material performs significantly better in thin film transistors than pentacene in so-called shelf-life tests in which the transistors are tested in air and stored in air over a period of months. Figure 1 shows data for a three-month trial in which the ON current for the An-2T-An device

- does not decay but devices based on pentacene and tetracene-bithiophene-tetratcene (tet-2T-tet) do decay significantly. The most likely explanation is the inherent stability of the An units relative to tet units or pentacene, which have known reactivity with oxygen. Current work is focused on making soluble derivatives of these hybrid molecules so that solution processed films can be tested. Frisbie and coworkers are also seeking to determine the single crystal structure so that the band structure of the new materials calculated by posdoc Demetio Filho and faculty investigator Brédas can be compared to the band structure of pentacene. [Merlo, J.A.; Newman, C.R.; Gerlach, C.P.; Kelley, T.W.; Muyres, D.V.; Fritz, S.E.; Toney, M.F.; **Frisbie, C.D. ***PChannel Organic Semiconductors Based on Hybrid Acene-Thiophene Molecules for Thin Film Transistor Applications*, J. Am. Chem. Soc. **2005**]

- Figure 1. Structure of An-2T-An synthesized by Dr. Chris Gerlach, collaborator at 3M. Lower left shows AFM image of a film of this material. The electrical characteristics (right) show performance superior to pentacene in terms of the shelf-life test, where the device is stored and periodically tested in air over the course of three months.
# Presentation: 780910

## Public Education about Safe Medicines in the Age of RFID

**The Partnership for Safe Medicines**
**James N. Class, Ph.D**
**Presentation for FDA RFID Workshop,**
**Bethesda, MD **
**Feb. 8, 2006**

## About Us

- The Partnership for Safe Medicines is a coalition of patient, physician, pharmacist, university, industry and other professional organizations committed to protecting the public from counterfeit or contraband medicines.
- ~50 Groups in U.S.
- European Liaison in London & growing...

## FDA’s Questions

*What type of consumer education is needed as the use of RFID in the drug supply chain becomes more prevalent? *
*What messages should be conveyed? *
*Who should develop consumer education program(s)? *
*Should there be a notice on the product package that an RFID tag is affixed to the product package? If so, what should the notice say?*

## Type of Education

***Q: What type of consumer education is needed as the use of RFID in the drug supply chain becomes more prevalent?***
* *
*	**	**A: The same that we need now....*

## Potential Over-Simplification

- A “Speedpass” solution?
- Or a FedEx-style system?
- Assumption that this pertains to all medicines everywhere
- Other parts of the world?
- Biologics?

## Type of Education II

***Q: What messages should be conveyed?**** *
*A1: Messages in line with Risk Management Principles: *
- Alert people of danger, _but_
- Empower them

## How We Do This Now...

**UPDATES**

**EMAIL ALERTS**

**ONLINE SHOPPING**

**LEGAL SAVINGS**

**CHECKLIST**

## Developers of Programs

***Q: Who should develop?***
*A: Experts (FDA, Academics, Industry) in partnership with patient and consumer groups*
- National Health Council’s Initiative
- Targeted Patient groups
- Consumer groups
- AARP

## Summary

- RFID adoption does not alter need for basic education.
- Consumer education needs to make risks clear, but empower _them_ to take action.
- No amount of technical expertise can overcome the need to get patients and consumers involved.

## It was an honor...

- James N. Class, Ph.D
- Executive Director
- Partnership for Safe Medicines
- 8100 Boone Blvd., Ste. 220
- Vienna, VA 22182
- 703-848-0164
- Senior Manager,
- Alliances, Access and Affordability
- PhRMA
- 1100 15th St. NW
- Ste. 900
- Washington, DC 20005
- 202-835-3467
# Presentation: 688323

## Patient Reported Compliance with Study Medication

|  | Salmeteroln=13,176 | Placebon=13,179 |
| --- | --- | --- |
| Compliance* with Study Medications, mean (SD) | 8.0 (2.58) | 7.8 (2.67) |
| Median Exposure (days)
[25th – 75th percentile] | 197 [179 – 201] | 197 [171 – 200] |
| Completed Treatment, n (%) | 9654 (73) | 9474 (72) |
| Discontinued Prematurely, n (%) | 2959 (22) | 3143 (24) |

***On a scale of 0-10 (0-missed all doses; 10—taken all doses), what number represents how well you followed the study MD’s instructions?**
# Presentation: 021239

## Ground-Based Inerting Proof of

- Concept Flight Test in Conjunction
- with the Boeing Company

## Outline

- Background
- Instrumentation
- Inerting Data
- Ground Testing
- Flight Testing

## Background

- Focus of the testing is to determine if the Existing Fleet Vented Fuel Tanks Will Maintain NEA Benefit for a Significant Amount of Time
- Boeing Offered Use a Boeing B-737NG as the Test Aircraft
- Air Liquide Provided an NEA Generator with Delivery Equipment at Low Cost
- Boeing to Provide Aircraft NEA Manifold, Support Personnel, Data Acquisition, and Most Instrumentation.
- Tech Center to Provide Oxygen Analysis Equipment

## Flight Test Instrumentation

- Oxygen Analysis System Provides 8 Channels of Continuous Oxygen Concentration Data
- Actively Controls Sample Inlet and Outlet Pressure.
- Flow Through Sensor Design
- Fluid Traps, Ejector/Evacuator, Flame Suppressors for Safety
- Other Instrumentation
- CWT Thermocouples
- Flight Data (air speed, altitude, attitude)
- Fuel Load
- Wind Data

## System Block Diagram

## Sample Port Location Diagram

## Fuel Tank Inerting

- Only Inerted the CWT with Properly Operating Manifold 3 Times
- Fuel Clogged Lines and Prevented Equal Distribution at Different Times
- Data Looks Consistent with Lab Observations
- Manifold not Balanced for Optimal Delivery Distribution
- Performed Non-Dimensional Analysis and Compared with Existing Models
- Volumetric Tank Exchange Measured at Approximately 1.7 Tank Volumes

## Slide 8

## Slide 9

## Flight/Ground Testing Data Reduction(Preliminary)

- Involved Averaging Oxygen Concentration and Ullage Temperature at the Three Primary Areas in CWT; Center Section, Left Cheek, and Right Cheek
- Calculated Average of Above Three Areas
- Marked Some Critical Events
- Data Plotted Every 1 Minute

## Raw Data Presented

## Raw Data Presented

## Slide 13

## Slide 14

## Slide 15

## Slide 16

## Slide 17

## Flight Testing Data

- Plotted Altitude with Average Bay [O2]s to Illustrate Effect of Flight
- Data Plotted Every 1 Minute

## Slide 19

## Slide 20

## Slide 21

## Slide 22

## Slide 23

## Flight Testing Data Comparison

- Fuel Load Effect Less Profound Then Predicted
- Cross Venting Effect Very Pronounced Over a Relatively Long Cruise
- Effect of Fuel Burn Appears to be the Primary Effect on CWT [O2]

## Slide 25

## Slide 26

## Slide 27

## Slide 28

## Summary

- GBI Can Provide Significant Protection Through Takeoff and the Beginning of Cruise to a Vented CWT (No X Venting) Even with Relatively High Fuel Loads
- Care Must be Taken to Ensure Minimal X Venting due to High Ground Winds and Some Flight Maneuvers
# Presentation: 672180

## TSS

- DISCH

- WINDSP

- SECCHI

- WATEMP

- TN

- TP

- CHLA

- precip

- NO23

- SAV_D

- SAV

- AVSUN

- COND

## TSS

- DISCH

- WINDSP

- SECCHI

- AVSUN

- COND

- TP

- SAV_D

- SAV

- CHLA

- NO23

- WATEMP

- TN

- precip

## TP

- SAV_D

- DISCH

- WINDSP

- SECCHI

- AVSUN

- COND

- TSS

- CHLA

- precip

- NO23

- WATEMP

- SAV

- TN

## sal

- TSS

- SAV

- CHLA

- WINDSP

- SECCHI

- AVSUN

- TN

- TP

- SAV_D

- DISCH

- precip

- NO23

- WATEMP

## sal

- SECCHI

- AVSUN

- TSS

- TN

- TP

- SAV_D

- DISCH

- SAV

- CHLA

- precip

- NO23

- WATEMP

- WINDSP

## SAV

- WINDSP

- SECCHI

- TSS

- TN

- TP

- DISCH

- precip

- NO23

- AVSUN

- WATEMP

- COND

- CHLA

- SAV_D

## cond

- SAV_D

- DISCH

- WINDSP

- TSS

- TN

- TP

- SAV

- CHLA

- SECCHI

- NO23

- WATEMP

- precip

- AVSUN

## SAV

- SAV_D

- SECCHI

- TSS

- TN

- TP

- DISCH

- CHLA

- WINDSP

- precip

- AVSUN

- WATEMP

- COND

- NO23

## cond

- DISCH

- SAV

- CHLA

- WINDSP

- SECCHI

- AVSUN

- TSS

- TN

- TP

- SAV_D

- precip

- NO23

- WATEMP

## TSS

- DISCH

- WINDSP

- SECCHI

- AVSUN

- WATEMP

- SAL

- TN

- TP

- SAV_D

- SAV

- precip

- NO23

- CHLA

## TSS

- SAV_D

- DISCH

- SAV

- WINDSP

- SECCHI

- AVSUN

- SAL

- TN

- TP

- CHLA

- precip

- NO23

- WATEMP

## TSS

- WINDSP

- SECCHI

- AVSUN

- SAL

- TN

- TP

- CHLA

- precip

- WATEMP

- NO23

- DISCH

- SAV_D

- SAV

## DISCH

- SAV_D

- WINDSP

- SECCHI

- AVSUN

- WATEMP

- SAL

- TSS

- TN

- TP

- SAV

- CHLA

- NO23

- precip

## TSS

- TN

- TP

- DISCH

- WINDSP

- SECCHI

- NO23

- AVSUN

- WATEMP

- SAL

- precip

- CHLA

- SAV_D

- SAV

## TSS

- TN

- TP

- DISCH

- WINDSP

- SECCHI

- NO23

- AVSUN

- SAL

- SAV_D

- SAV

- precip

- WATEMP

- CHLA
# Presentation: 666869

## SSG-WI
Transmission Report
October 2003

SSG-WI 
Planning Work Group

***Transmission Report***
*October 2003*
***SSG-WI ***
***Planning Work Group***

## Relationship to Subregional Planning Groups

- A beneficial and effective planning relationship has been established between SSG-WI and the SPGs
- This should be encouraged to continue

## Slide 3

## SSG-WI Study Objectives

## Study Program

- 2008 – Base Case
- 2013
- Gas – Assumes 86% of new generation is fueled with gas near load centers
- Coal – Assumes 66% of new generation is coal fired remote from load centers
- Renewable – Assumes 72% of new generation is from renewable (wind, etc.) remote from load

## 2008 Findings

- Identified paths that may be congested in the near future
- In the 2008 study, identified approximately $110 million in unrealized production cost due to path congestion (with planned facilities).
- In coordination with SSG-WI, STEP (subregional group) is looking at new enhancements between Arizona and California that could save $60 million per year.

## Slide 7

## 2013 Findings

- Identified transmission facilities necessary to alleviate path congestion for 3 bookend resource scenarios
- Gas – 1325 miles - $2.6 billion
- Coal – 7605 miles - $16.7 billion
- Renewable – 3360 miles - $6.7 billion

## Western Interconnect Transmission Paths

**Western Interconnect Transmission Paths**

***Seams Steering Group of the Western Interconnection***

**Gas **

**Scenario**

**Coal**

**Renewables**

**+**

**+**

**DC**

**Scenario   **

**Scenario**

**+**

**+**

**+**

**+**

## Slide 10

## Considerations

- This SSG-WI study was a high level first cut at identifying future transmission needs for the Western Interconnection.
- Additional studies are required by SSG-WI and/or Subregional Groups before specific projects can be identified and proposed for implementation.

## Next Steps

**Federal, State policymakers** –
- address issues such as cost allocation and cost recovery to encourage investment in transmission and demand side alternatives.
- incorporate SSG-WI study results when considering energy policy and Renewable Portfolio Standards
**Subregional Planning Groups** –
- perform additional in-depth studies.

## Next Steps (Continued)

**SSG-WI** –
- Perform annual existing system utilization reviews
- Perform annual studies of potential future needs and expansion issues
- Identify modeling improvements to enhance the usefulness of future studies
**Subregional Planning Groups and SSG-WI** –
- Continue to build a close working relationship to address planning and implementation issues.
# Presentation: 182006

## biology

*Sustainability Science*

- Robustness

- Evolvability

- BIO AC Meeting 19 April 2007

*How do biological systems create, test and maintain adaptive capacity?*

*Critical thresholds*

*State changes*

*Cross-scale feedbacks*

*Lags and inertia*

*biology*

- J. Cancalosi

## + humans

*Sustainability Science*

*Discontinuity*

*Nonlinearity*

*Abrupt change*

*Forecasting*

*+ humans*

*How do slowly changing variables interact with boundary conditions and variables that change on faster time scales?*

- Mississippi River and Missouri River from Space - NASA

- American Chestnut

## complex systems

*Sustainability Science*

*How do latitude, resistance and precariousness of a system affect resilience?*

- supanet.com

- how close the current state of the system is to a limit or threshold

- the ease or difficulty of changing the system

- the maximum amount a system can be changed before losing its ability to recover

*complex systems*

- Keeling CO2 curve

***Latitude***

*Precariousness*

*Resistance*

## Adaptation

*Adaptation*

*Transformation*

*How do the actors in a system influence resilience and robustness?*
*What governs buffering capacity --- the ability to absorb stress and shock without fundamental change?*

*How is novelty admitted to a system?*
*What governs evolvability --- the ability of a system to move in a fundamentally different trajectory?*

*Sustainability Science*
# Presentation: 831360

##  A COTS system will be used: Fenwal Engineered Fire Suppression System designed for use with 3MTM NovecTM 1230 Fire Protection Fluid.

-  FAATC will initiate testing program to evaluate NovecTM 1230 as a possible candidate to replace Halon 1301 in the cargo compartment area.
-  Testing will start 2nd Quarter 2006.
-  A COTS system will be used: Fenwal Engineered Fire Suppression System designed for use with 3MTM NovecTM 1230 Fire Protection Fluid.
-  The latest version (2nd Update, June 2005) of the Minimum Performance Standard for Aircraft Cargo Compartment Fire Suppression Systems will be used during this program.
-  Partners: FAA & 3MTM
-  FAA POC: John Reinhardt 609-485-5034

## Slide 2
# Presentation: 728895

## Malaysia: Wastewater Treatment Sector Overview

- Vivian How
- Commercial Specialist
- U.S. Commercial Service Kuala Lumpur

## Market Overview

- Environmental Quality Act 1974
- Department of Environment
- Ministry of Natural Resources and Environment
- Insufficient power, limited resources and manpower, lack of technical expertise, weak prosecution system

## Sewage and Industrial Effluents Regulations 1979

|  | Standard A | Standard B |
| --- | --- | --- |
| BOD | 20 | 50 |
| COD | 50 | 100 |
| Suspended Solids | 50 | 100 |
| Mercury | 0.005 | 0.005 |
| Cyanide | 0.05 | 0.10 |
| Lead | 0.10 | 0.50 |
| Sulfides | 0.50 | 0.50 |
| Oil and Grease | Not detectable | 10 |

*All units are in parts per million (ppm)*

## Market Size

- Total market size of water and wastewater treatment equipment in 2005: $ 878 million (source: World Trade Atlas)
- In 2005, U.S. has second largest market share of 20%
- Primary competitor: Japan with market share of 31%

## Best Prospects

- Integrated wastewater systems including process design and engineering, pollution prevention technologies, and wastewater recycling.
- Advanced water recovery systems for solvents, waste oil, acid and metals.
- High tech water monitoring and analytical equipment
- Oil-water separators

## Market Entry

- Local presence either representative, agent/distributor
- Product support and after-sales service
- “Well-connected” partners

## Market Access & Obstacles

- Few trade barriers
- Costlier
- Lack of back-up support

## Trade Events

- Asia Water 2008, April 1-3, 2008
- 	Kuala Lumpur Convention Center
- 	Organized by AMB Exhibitions
- 	For more information: _[www.asiawater.org](http://www.asiawater.org/)_

## Key Contacts

- Malaysia Department of Environment
- 	_[www.doe.gov.my](http://www.doe.gov.my/)_
- Malaysia Ministry of Natural Resources & Environment
- 	_[www.nre.gov.my](http://www.nre.gov.my/)_
- Indah Water Konsortium
- 	_[www.iwk.com.my](http://www.iwk.com.my/)_

## U.S. Commercial Service

- 	U.S.Commercial Service Kuala Lumpur
- 	American Embassy
- 	376 Jalan Tun Razak
- 	50400 Kuala Lumpur
- 	Malaysia
- 	Tel: +60-3-2168-4825
- 	Fax: +60-3-2168-8350
- 	Vivian How, Commercial Specialist
- 	E-mail: _[vivian.how@mail.doc.gov](mailto:vivian.how@mail.doc.gov)_
- 	Website: www.buyusa.gov/malaysia
# Presentation: 110137

## 
EnergySmart Grocer

- EnergySmart Grocer

## What We’ll Cover

- EnergySmart Grocer Auditing Tools
- EnergySmart Grocer Customer Interaction
- Q & A

## Auditing Hardware

**Portable Printer**

**Tablet**

**Infrared Thermometer**

**Voltage Tester**

**Digital Camera**

## Software: GrocerSmart

- Recommends energy efficiency measures, associated energy cost savings, project payback, projected rebates

## Scheduling Audits

- Identify
- Contact
- Inform
- Scheduled
- Reminder

## Upon Arrival

- Photograph business front
- Overview audit process with
- 	owner/manager
- Input site specific data, i.e. store
- 	hours, contact names, comments

## The Audit

- Compressor Room
- Controls
- Heat reclaim
- Defrost schedules
- Condensers
- Walk-in (Cooler and
- Freezer)
- Evap fans
- Efficient motors
- Backroom Loads

## The Audit

- Cases
- Efficiency
- Lighting
- Too much heat?
- Lighting
- HVAC
- Cooking

## Produce the Energy Savings Report

- Derive output data from GrocerSmart 3.0
- Merge grocer specific data into document template
- System data
- Process data
- Photographs
- Recommend appropriate phases

## Energy Saving Report (ESR)

**Summary Letter**

**pictures**

**Results**

**Audit Inputs**

## ESR Presentation

- Present ESR and gain commitment
- Answer Grocer questions
- Execute agreement for instant savings items
- Identify follow up items, engage appropriate parties

## Direct Installs

- ESG Installs
- CFLs and Cooler Misers
- Promotes goodwill
- Instant savings for customer

## Working With Contractors

- Does customer need contractor referral?
- Contractor(s) bid on job
- Financial arrangements, timing
- 	and agreements worked out
- 	by contractor and customer

## Follow-up

- Not a Program Preferred Contractor?
- Helps chosen contractor understand T&C
- Understand program requirements Program ensures contractor bids on job
- Answer remaining questions
- Review bids to verify they meet T&C
- Gather documents

## Program Contact Info

- Steve Cofer
- 503-595-4472
- scofer@peci.org

## Thanks for your time
# Presentation: 597628

## Low Wind Speed Technology Opportunity

**Low Wind Speed Technology Opportunity**

**Notes:**
Here’s why we’re looking at low-wind speed technology...

Red areas are where most of development taking place today.

With a LWST we can access the green areas too.

## Hydropower Installed Capacity

- 78 GW installed capacity
- Approx.170 Federal projects (~39 GW), 2,000 private projects (~39 GW)

- Official use only

**Notes:**
Hydro resources are spread throughout the country – here on the east hydro plays a strong role in meeting energy needs.  

While no new impoundment facilities are planned, we are working to deliver advanced turbines that limit fish-kills and downstream oxygen levels, two critical issues related to hydropower generation.

## Wind Power:U.S. Installed Capacity, 1981-2002
# Presentation: 090148

##  High throughput fold prediction for genome annotation

- 	Develop new homology models
- 	“Rosetta” approach to ab initio methods
- 	Fold recognition
-  Algorithm development, resources needed, beyond 200 residues need big parallel machines
- 	1⁄2 teraflop ~ 200 seqs/day so a genome of a bacteria takes 2 	weeks to a month
-  Need finished sequences - who will support it?
-  How many bacteria a year?
- 	20 bacteria a year – resource needs are 2 to 5 Tflops to do 	homology and threading and folding
-  Need to put in other experimental data eg., mass spec. & search high throughput data
-  Many other research areas – include evolutionary methods for function & structure & relationships
-  Take high throughput information plus structural data  automate ways to model complexes (mass spec, protein arrays, cross-linking, fluorescence)
-  How do we deal with molecules whose folds we do not know?
- Membrane proteins

##  Develop integrated experimental and computational approaches to structures and function for hard to isolate proteins & complexes

- 	- Membrane proteins
- 	- Here computation and experiment are directly linked
- 	- Automation & high throughput
- 	- New methods
- 	- All types of data – nmr, x-ray, neutron, microscopy, imaging
- 	- Specific example: mass spec analysis – probabilities, mapping out 	networks, big computing need, large data sets, how do you pull out the 	proteins, how do you do post-translational mods?
-  Pushing the envelope for biophysical modeling - Predict actual behavior of complexes for a specific set of proteins chosen for biology reasons from network analysis and other expts.
- 	- protein-protein interaction,
- 	- ligand-protein interactions,
- 	- electron transfer interactions,
- 	- membranes,
- 	- push dimensions,
- 	- MD & QM/MM & QM push the high end computing & require methods 	development (examples, codes & force fields)

## Links & Other Issues

-  Other Issues:
- 	- Database of protein structures – predictions
- 	- Need reliable staffing, curation vs. generation
- 	- What do we do with all of the annotated genomes for microbes
- 	- Data amounts, data accessibility, metadata issues
-  Link to SciDAC - MICS
- 	- Biology Enabling Technology Center,
- 	- Common Component Architectures,
- 	- middleware,
- 	- Collaborative Problem Solving Environments
- 	- a CompBio Pilot - Build off current efforts
-  ASCI & high performance computers
-  Link to NSF centers (SDSC)
-  Link to new NIH Inst on Bioinformatics & Imaging
-  Industry partners - computational & Bio companies
-  Large partnerships among labs like SciDAC
# Presentation: 014200

## MOSTLY ION ACCELERATION AND ABUNDANCES

- Ron Murphy

## ACCELERATION

- Reames
- impulsive flare acceleration must occur before temperature becomes 3-5 MK or all species will have the same Q/A
- Miller
- wave-particle resonant acceleration can produce observed element enhancements
- two kinds of waves are required to accelerate Fe,... and 3H, e

- Falcone
- reported >10 GeV protons with Milagrito
- Leske
- using ACE/SIS, showed that the isotope enhancements and the abundance enhancements are correlated implying the same mechanism is responsible

- Cohen
- Using ACE/SIS, showed that the 3He/4He ratio increased with energy
- Holman
- Showed that acceleration with a DC electric field can produce abundance enhancements
- Litvinenko
- sufficiently-high field can produce large e/p ratios

- Brown
- neutral p-e beam: as electrons are dragged along, they are heated and MeV protons can give rise to 16 keV electrons with about 20% efficiency
- several authors discussed high-frequency radio observations
- provide information on >1 MeV electrons for comparison with HXRs

- Droge
- fit results of acceleration model to Helios 1 particle data
- data indicated both power laws and low-energy turnovers (Bessel function)
- Trottet
- importance of H images for response of the atmosphere to energy input

- Ryan
- very long-lasting 2.223 MeV neutron capture line in several flares suggest a very large volume
- Simnett
- CME observations show that large coronal structures are involved

## Energy in Ions

- Energy in ions is comparable to that in electrons and 75% can be in alpha particles and heavier ions
- Brosius
- time profile of L can give information about low energy proton beams
- Henoux
- warned how the electrons and pressure effects can affect the interpretation of line profile

##  Abundances

- Von Steiger
- FIP not as pronounced in fast solar wind than slow and suggested first ionization TIME is a better organizer
- SW and corona 4He less than that from helioseismology-remaining He-rich material could be that occasionally seen in gamma-ray flares and SW

- Mandzhavidze
- FIP effect has already set in in the chromosphere
- high /p and He/H
- Mullan
- looked at reconnection jets in chromosphere
- dragging of neutrals by ions produces abundance enhancements
- depends only on ion density

- Mazur
- peculiar abundance enhancements sometimes seen in large proton flares could be due to remnant material after impulsive flares
- Vilmer
- in a trap + precipitation model, looked at time dependence of line ratios
- June 1 flare

- Share
- gamma-ray lines provide information on both ambient and accelerated particle abundances
- 0.511 MeV positron annihilation line gives a temperature measurement of annihilation region
- ion energy

## FLARE PREDICTION

- Zirin
- crucial parameters are size and magnetic complexity
- Kiplinger
- time dependence of Hard X-ray spectrum is good indicator of proton flare
# Presentation: 018446

## Water

**Our Most Precious Resource**

***Water***

## Fire Can Affect Water Quality

## Nutrients

**Nutrients**

**Metals**

**Copper**
**Manganese**
**Iron**
**Lead**
**Zinc**
**Strontium**

**Nitrogen**
**Phosphorus**

**Radiation**

**Cesium –137**
**Strontium –90**
**Plutonium**
**Uranium**

*Nutrients, metals and *
*radionuclides can *
*increase in runoff after fires*

**Notes:**
Harmful Metals

## Slide 4

## Slide 5

## Slide 6

## Drinking water

**Fishing **
**Irrigation crops**
**Swimming / Recreation**

***Exposure to ***
***Contaminated Water***

## Water dependent organisms

***Water dependent organisms***

## What actions have 

***been taken?***

## Control Measure-Straw Wattles 

- The wattles on the side are for keeping sediment from going into the stream.

***Erosion Control***

## Weirs

- Los Alamos Canyon

## Samplers

## Stream Gauging Station

***Stream Gauging Station***

## Risk Assessment

**New Mexico Environment Department**
**New Mexico Department of Health**
**U.S. Department of Energy**
**U.S. Environmental Protection Agency**
**Los Alamos National Laboratory**
**U.S. Forest Service**
**U.S. Army Corps of Engineers**

**Notes:**
Must be conducted by federal organizations
This must be completed for modeling and sampling to begin.

## What more 

***should be done?***

## *Consultant  

****Public Outreach***

***Proposal***

## An independent consultant will give an assessment of the following: 

**Ensure the public health**

**Erosion control methods**

**Risk Assessment**

**Monitoring methods and results**

## Public Outreach

_**Education**_

- Keep Public Informed

**Meetings**
**Websites**
**Publications**
**Public Service Announcements**

## Public Outreach

_**Goals**_

**Increase awareness of water quality after fire**
**Tell what has been done **
**Integrate cultural concerns**
**Tell if federal and state water quality laws are being followed**

## Dedicated to Understanding Dangers to our Environment

**D****edicated to ****U****nderstanding ****D****angers to our ****E****nvironment**
# Presentation: 886432

## Module 7:Preparation for Testing –   Supplies and Kits

## Learning Objectives

- At the end of this module, you will be able to:
- List and identify all the supplies required for HIV rapid testing
- List and identify all the components of test kits for HIV rapid testing

## Memory Game: Supplies  & Materials

- How To Play:
- Spend _3_ min. browsing through the display and learn the items
- Spend _1_ min. writing down as many items as possible (without looking)
- Tally up the total number of items you write down
- The person who remembers the most items wins.

## Supplies  & Materials Checklist

- HIV Rapid testing kits
- Alcohol
- Cotton Gauze / Wool
- Sterile Lancets
- Sharps bin or  Disinfectant jar for lancets
- Pen for marking or labeling

- Gloves
- Aprons or laboratory coats
- Timer, clock, or wrist watch with minute hand
- Transfer pipettes, pipette tips

## Supplies  & Materials Checklist (Cont’d)

- Paper towels (for bench coating, cleaning, and hand washing)
- Soap for hand washing
- Leak-proof bag for containing or moving  labeled biohazard waste for incineration
- Disinfectant e.g. Jik, Chlorox
- Band-Aids or plasters
- Note:  Some supplies may be obtained locally, some may be obtained through central stores or externally

**Notes:**
Show each supply item

## Don’t forget:
Positive and Negative controls
Register or book for recording results
Spray bottle for making bleach solution
Standard Operating Procedures

- Positive and Negative controls
- Register or book for recording results
- Spray bottle for making bleach solution
- Standard Operating Procedures

- Thermometers

**Supplies  & Materials Checklist**** (Cont’d)**

**Notes:**
Show each supply item

## Gloves

- Single use disposable gloves
- Latex or polypropylene
- Without evidence of holes or tearing

## Alcohol

## Cotton Gauze or Cotton Balls

- Single-use, hazardous waste disposal

## Sterile Lancets

- Single-use, hazardous waste disposal

## Pipette 

- Transfer Pipette

- Automatic Pipette

## Timer

## Standard Operating Proceduresand Forms

## Labeling Pens and Writing Pens

- Labeling Pens

-   Writing Pens

## Sharps Bins / Disinfectant Jar 

## Proper Disposal of Contaminated Materials

## Waste Disposal

## Household Bleach and Container

## Examine Test Kits

- Display test kits used in-country
- Examine the different components found in each of the Rapid Test kits, e.g.,:
- Desiccant packet – This is not used when performing the test.  It only serves to keep the packet contents dry before use.  It should be discarded when the test kit packet is opened.
- Buffer solution – Required by some kits

## Organize Your Work Area

## Summary

- What are these items used for:
- Gloves
- Alcohol swabs
- Cotton balls or gauze
- Sterile lancets
- Pipette
- Timer
- Standard operating procedures
- Marking pens
- Sharps disposal bins
- Disinfectant jar
- Bleach

- What are the components of the following test kits:
- Test kit 1
- Test kit 2
- Test kit 3
# Presentation: 927532

## Independent Laboratory TestingPART 6 Regulations

- Mechanical & Engineering Safety Division
- Robert Setren
- Mechanical Engineer

## M+ESD

- 16 Engineers and Scientists, - 2 engineering technicians
- Responsible for mechanical aspects of mining equipment as it relates to the safety and health of miners
- Approval programs include dust collectors evaluated under part 33 and diesel machines evaluated under part 36

## M+ESD

- Our laboratory and field test functions include:
- Dust collector field test followed by laboratory analysis of dust samples
- Laboratory and field tests of diesel machines and components
- Engines – emissions – under part 7
- Power Package – surface temperature, explosion, and safety control tests under Parts 7 and 36
- Diesel powered machine field tests under part 36

## M+ESD

- Test procedures are documented in 30CFR and standard operating procedures

## M+ESD

- An independent lab considering conducting testing for the MSHA approval of a mining product must produce a product equal or better than our present capability to maintain the integrity of the MSHA approval
- Test equipment must be equal or better than MSHA including up to date calibration– equipment specifications found in 30CFR, MSHA website, or call us

## M+ESD

- Data collecting, record keeping, report writing required
- Quality Assurance

## M+ESD

- Any ?
- Call the M+ESD and speak to us anytime
- 304 547 2042, John Faini
# Presentation: 036319

## Disclosure Avoidance and Analytical Validity in “On The Map”

- Fredrik Andersson
- February 1, 2007

## The Challenge: Maximize Analytical Validity of Data Subject to Strict Confidentiality Protection Constraints

- Analytical Validity of Data

- Degree of confidentiality protection

- Synthetic Data

- Cell Suppression

## Goals of Presentation

- Present the Disclosure Avoidance Protocol for *On The Map*
- Demonstrate that synthetic data methods can be used to protect confidentiality while preserving analytical validity

## Basic Facts about the Disclosure Protection System for OnTheMap

- Goal: “to protect confidentiality while preserving analytical validity of data”
- No cell suppression
- Synthetic place of residence data
- Workplace data protected by QWI disclosure protection system (“dynamically consistent noise infusion”)
- First-ever data product released by a Statistical Agency (Feb 2006) that relies on synthetic data method as its primary disclosure avoidance technique

## Disclosure Avoidance

*Bayesian* statistical techniques to create a *partially synthetic* version of the confidential data
- Block of origin counts sampled from a *posterior predictive distribution* conditional on destination block and worker characteristics (earnings, industry, age, ownership sector)
- The *posterior predictive distribution* is derived from combining the *likelihood* (“true data”) with a *prior*
- So, what does this really mean???

## Creation of Synthetic Data

*Fictional example: Distribution of place of residence for workers in a specific block, industry, earnings category, age category, ownership sector*

- Q: Why not sample directly from the likelihood/What’s the role of a prior?

- Q: How are the priors constructed?

- Q: How much weight is given to the prior?

## Key Implication

- The relative weight of the prior when sampling from the posterior distribution is inversely related to the size of the population being synthesized
- For larger populations the synthetic place of residence data closely mimic underlying data
- For small populations the synthetic place of residence data are relatively more “noisy” to protect confidentiality
- Important to keep in mind when making inferences using OnTheMap
- How “noisy” an estimate is can be assessed by taking advantage of all 10 implicates of the synthetic data available on the virtual RDC

## Empirical Results on Analytical Validity & Confidentiality Protection

## The residence patterns in synthetic data mimic confidential data well

## Level of protection increases as population in work block decreases

**Level of protection increases as population in work block decreases**

## Key Properties in data, such as commute distance, are preserved in synthetic data
# Presentation: 494697

## Kurt Brorson, Ph.D.

- Division of Monoclonal Antibodies
- OPS/CDER

## Biopharmaceuticals are complex-

- more potential heterogeneity than small molecule drugs

## Heterogeneity in recombinant products and Monoclonal antibodies

- Cell culture related
- Fermentation is an artificial process
- vs. plasma or other natural sources
- Bioreactor conditions can impact:
- Glycosylation
- Some charge variants
- Amino acid substitutions (leu  norleucine, etc)
- The cell line can impact:
- Adduct placement
- Folding/misfolding
- Cysteine pairing

## Heterogeneity in recombinant products and Monoclonal antibodies

- Stability related
- Pure, high concentration protein is an artificial system
- vs. proteins in cells or bodily fluids
- Plasma and recombinant products face same challenges
- Clipping
- Aggregation
- Deamidation (Asn  Asp; Gln  Glu; loss of -NH2 on Lys
- Oxidation (Met  Met sulfoxide)

## Antibody Heterogeneity- 

- Antibody Heterogeneity-
- Major role of glycosylation, C-terminal lys

- K

- K

## Expected Heterogeneity-experience with monoclonal antibodies

- C terminal lysine variability occurs in most monoclonal antibody products
- Manufacturers set acceptable ranges for each species
- Can be measured by various techniques, wCEX-HPLC, IEF, others
- Doesn’t seem to impact potency or safety profile

## Monoclonal antibodiesUnacceptable, stress induced heterogeneity

- Detectable by various methods
- Manufacturers set stability specifications
- Can compromise potency if OOS

## Heterogeneity-experience with other recombinant products

- Case 1: protein terminus heterogeneity
- Traced to metaloprotease
- Minimal impact on potency
- Case 2: product clipping
- Minimal impact on potency
- Case 3: N-terminal glutamine cyclization
- Cyclized form had increased activity

## Strategies to maintain product quality

- Testing- lot release & stability
- Employ a range of assays
- IEF, wCEX-HPLC- charge variants
- Tryptic peptide mapping, N & C-terminal sqxing- amino acid sequence variants, oxidation, adduct formation
- SDS-PAGE, SEC-HPLC- clipping, aggregate formation
- Mass spectroscopy- molecular weight changes
- Specialized assays- carbohydrate analysis, IsoQuant, others
- Set acceptable ranges for quality attributes
- Based on clinical & manufacturing experience

## Strategies to maintain product quality

- Formulation, purification and storage- minimize change over time
- Formulation
- Lyophilization vs. liquid
- pH control
- Stabilizers (sugars, polyhydric alcohols)
- Surfactants
- N2 overlay in vial
- Product attributes:
- Residual enzymes
- Some metals (Cu++, etc.)
- Storage
- Correct temperature
- Minimize O2, bubbles in vial
- Protect from light

## Strategies: assessment of impact

- If heterogeneity can’t be avoided...
- Control it
- Does heterogeneity impact API potency?
- Is it near effector parts of protein?
- Assess via potency assay
- Does heterogeneity impact bioavailability?
- Major glycoform changes
- Assess in PK studies
- Does heterogeneity impact immunogenicity?
- Placement, type, extent of substitutions
- Sometimes assess in immunogenicity studies
- Case dependent
# Presentation: 075151

## Star Databases:  People & Activities

**Jeff Porter**:	**Online/Offline API & Administration**
**Torre Wenaus**:	**File & Run Catalog**
**Sasha Vanyashi**:	**ParameterDB & NOVA Tools**
**Laurent Conin**:	**Db-Buffer & Query Handler**
**May’99**:		**RelationalDB **** - ****MySQL**
- 			**File Catalog****  - Torre Wenaus**
**June’99**:		**ParameterDB **** - Sasha Vanyashi**
**July’99**:		**StDbLib prototype****  - Jeff Porter**
**mid-Aug**:		**StDbLib production****  - Jeff Porter & Laurent Conin**
**Next Steps**:
- 	**Online Run Configuration, SlowControls<->ConditionsDB, Calibration QA & Control procedures, ...**

## Star Databases:  Software Component Overview

## Star Databases:  1) Storage System

## Star Databases:  2) Common API 

## Star Databases: 3) Administration Tools
# Presentation: 118594

## Percent Increase in  

- 0

- 10

- 20

- 30

- 40

- 50

**Percent Increase in ******** **

- S

- T

- E

- E

- L

- H

- E

- A

- D

- C

- H

- I

- N

- O

- O

- K

- CHUM

- Lower Columbia

- Upper Columbia

- Snake spr /sum

- Snake fall

- Williamette

- Lower Columbia

- Mid Columbia

- Upper Columbia

- Snake

- Williamette

## Maximum Percent Change in Pop. Growth Rate with Harvest Moratoria

**Maximum Percent Change in Pop. Growth Rate ****with Harvest Moratoria**

- 0

- 5

- 10

- 15

- 20

- 25

- 30

- 35

- L. Columbia Chinook

- U. Columbia Spr Chinook

- Snake R. Spr/Sum Chinook

- Snake R. Fall Chinook

- U. Willamette Chinook

- L. Columbia Win. Steelhead

- L. Columbia Sum. Steelhead

- Mid Columbia Steelhead

- U. Columbia Steelhead

- Snake R. Steelhead

- U. Willamette Steelhead

**Percent Change in lambda  **
# Presentation: 118330

## The Wildfire: 

**Beware **and** Prepare** to reduce the threat of wildfire to residents in the wildland urban interface zone.  This checklist will help you identify ways to reduce home and property wildfire hazards and to prepare your family and neighbors for the event of wildfire.
- Suggested graphics for Homeowner Checklist: logo

## Wildfire Safety Precautions

- Home Construction
- Existing Home Protection
- Evacuation Plan

## Home Construction

- Build home on most level portion of lot.
- Roofs and exteriors should be of fire resistant materials
- Avoid cedar shakes and shingles.
- Screen eaves, attic and floor openings.  Avoid accumulation of flammable material.
- Screen the chimney and stove pipe.
- Remove site preparation debris.

## Existing Home Protection

- Reduce surrounding wildfire fuels, such as rotting logs, branches, brush and other flammable materials.
- Do exterior home inspection at least once a year before summer.
- Remove overhanging tree limbs, moss, and needles from roof and gutters.
- Clean chimneys and stove pipes; check their screens.

## Keep storage areas clean and tidy, never allow rages or newspaper to accumulate, and store flammable liquids in approved containers.
Maintain a survivable space around the house.  A large green lawn is ideal.
Remove highly flammable plants from around the house, especially on the side most exposed to prevailing winds, and the downside slope.
Remove nearby heavy ground vegetation and stumps.
Do not stack firewood against the house.

- Maintain a survivable space around the house.  A large green lawn is ideal.
- Remove highly flammable plants from around the house, especially on the side most exposed to prevailing winds, and the downside slope.
- Remove nearby heavy ground vegetation and stumps.
- Do not stack firewood against the house.

- Existing Home Protection Continued

## Wildfire Safety Precautions

- Develop control plans with family and neighbors.
- Have an adequate water supply.
- Pre-connect garden hose with nozzle and sprinkler system to access all structural exterior, including the roof.
- For a non-pressurized water system, have a large barrel of water and a five gallon bucket accessible.

## Evacuation Plan

- Develop a standard evacuation route.
- Establish an alert system alarm.
- Have an agreed upon meeting point for family members.
- Review your prized possessions in advance and consider storage in safety deposit boxes.
- Have a list of items to evacuate (important personal papers, photo albums, etc.)
- Know power and gas shut-off procedures.
- If you have an independent will, turn the sprinkler system on before leaving.
- Do not panic.
# Presentation: 197232

## Work(S) in Progressor Trails Theme

- ITDS (Interagency Trail Data Standard)
- NPS Data Transfer Standard and Implementation Plan
- FGDC Trail Data Standard
- FMSS Trail Data Collection
- DOI EGIM IEA efforts Tails proposed as a Pilot effort for Blue-Print ADS

## Bottom-Line Benefits

- Trail Data Standards

- Improved communication and efficiency
- For our internal and external customers
- Through proactive trails coordination and collaboration

## InteragencyTrail Data Standards

- or better named Interagency Trail Content Standard
- USDA Forest Service – Bureau Of Land Management -
- National Park Service – US Fish and Wildlife Service

- _[http://www.nps.gov/gis/trails/](http://www.nps.gov/gis/trails/)_
- Focus on National Trail System for Managers
- Work Started at 2001 Spatial Odyssey GIS Conference, Primm, NV
- Currently working on Version 2 of the Data Standard

## Factors to Consider

- Interagency core data set
- Data isn’t cheap!
- Standardized terminology
- Existing, standardized data attributes
- Implementation feasibility & timeframes

## Is the Trail Accessible?Data Standard Example

**What Are the Core Attributes?**
- For managing the Geospatial Component?
- For interrelationships (Tabular) with other data sources?
- Which is the authoritative source?

## FGDC Data Standard

- Partnership of FGDC, NPS, and NCSU
- The FGDC-supported Trail Data Standard will provide, in two separate parts: data content and data transfer standards for trails of all kinds:
- Initially had Data QA/QC component but removed based on comments
**Data Content **provides semantic definitions of a set of objects. This part specifies and defines the data elements associated with trails.
**Data Transfer **describes how to produce or consume packages of data, independent of technology and applications that will facilitate moving data between agencies and systems.

- Inclusive of ITDS, NPS, and others:

## Proposal Review

- Barry Schlesinger
- Barry Reff
- Doug Nebert (V2 comments)

## V1 Review Comments

- Tighten Up Title & Scope
- Involve other groups outside NPS & Fed domains
- Timeline
- New FGS Work Group?

## V2 Review Comments

- Lacks non-federal involvement
- UML modeling

## Questions?
# Presentation: 042316

## Section 22

_***Section 22***_
***Reaction Control System***

*** ******. . . Michael McCullough***
*Swales Aerospace, Inc.*

## Reaction Control System

## “As Run” Verification Matrix

## Projected Power On Time

## RCS Status

***RCS Status***

***There are no open work orders, PRs, Redbook items, or action items ***
***The long term pressure decay verification continues.***
***There has been no detectable pressure decay during the test (8 months)***
***The RCS is ready for pre-launch processing and launch ***
***All Launch Site Procedures are complete, reviewed and have tentative approval***
***SCAPE training complete by Swales and Primex personnel***
***Hydrazine delivered to the range for both EO-1 and SAC-C***

***Reaction Control Subsystem is READY ******for launch site activities ***
# Presentation: 130104

## Near Shore Marine Forecasting with IFPS

- Brian Meade
- WFO Grand Rapids, MI

## Default GFE Domain

## GRR Marine domain– 2KM Res

## GRR GFE “Super Launcher”

## GFE Product Generation Menu

## GLERL Wave Model Ingest Issues:“Missing” Data Pixels Along Coast

## New WaveFillTool– Tom LeFebvre

## Another Solution: “Shift Grid” Tool

## Spurious data Pixels

## XNOW and GFE Text Formatters: Together at Last!

## XNOW for GFE: Ability to “flex” NSH Zones with GFE Text Formatters

## Snowfall Map After Event

- Create new element in localConfig called “SnowMap” with same definition as “SnowAmt”. Create and stretch a grid that correlates with the begin and end time of the event.

## Some GRR GFE Procedures

- Create_RH_and_WindChill
- Create_RH_and_HeatIndex
- Get_T_from_MaxTMinT_00Z, _12Z
- Load_LAPS_Last_12hrs
- Load_MSAS_Last_12hrs
- Load_LkBreeze_Day1, _Day2

## Some GRR GFE Smart Tools

- MaxT_from_850_Eta, _Avn
- MaxT_from_1000_850_Thck
- Wx_fm_Pop
- PoP_fm_Wx