# Presentation: 328307

## NVAC02-04-04

- W. R. Dowdle

## Laboratory Containment of Wild Poliovirus in the United States

- Phase I
- National Survey and Inventory
- Final Report
- January 15, 2004

## The Purpose of Laboratory Containment

- To minimize the risk of reintroducing wild polioviruses into the community after eradication

##  Purpose of Phase I 

- To encourage labs to dispose of unneeded wild poliovirus materials
- Establish National Inventories of laboratories retaining such materials.

## US Survey and Inventory

- Began in October 2001
- NVPO through contract with the Task Force for Child Survival and Development
- Working in partnership with CDC

## Steps in the survey process

- Develop the Action Plan
- Authorize the survey (WHO, HHS, OMB)
- Enlist support of laboratory community
- Perform pilot surveys (x2)
- Establish database of institutions/labs
- Develop survey instruments
- Implement the survey

## Database: Categories of Institutions

- <date/time>

- CLIA Certified
- Non-Complex Testing

**Most likely to possess (1,216)**

**Least likely to possess (26,844)**

- CLIA Certified
- Complex Testing

**May possess     (4,369)**

## <footer>

- <date/time>

## Results of National Survey*

- <date/time>

|  | Survey Database (Institutions) |  
Yet to Respond  |
| --- | --- | --- |
| 
Most likely to possess | # | # |
| Academic | 437 | 0 |
| Federal Government | 13 | 0 |
| Industrial | 668 | 0 |
| State & Local Government | 98 | 0 |
|  |  |  |
| Subtotal | 1,216 | 0 |
| 
May possess |  |  |
| CLIA certified complex testing | 4,369 | 0 |
| 
Least likely to possess |  |  |
| CLIA certified non-complex testing | 26,844 | 2,638 |
| 
Total | 
32,429† | 
0 |

-  * November 2003  † **Represents a total of 105,356 laboratories surveyed**

## Finding no WPV materials among 24,206 responders confirmed small clinical labs were unlikely risks.Follow-up of “least likely” labs  discontinued per NVAC workgroup .

## Number of institutions on National Inventory/

- <date/time>

|  | Institutions Retain-ing Materials | Laboratories Retaining Materials |  |  |  |
| --- | --- | --- | --- | --- | --- |
| 
Most likely to possess | # | Infectious | Potential Infectious | Both | Total |
| Academic | 63 | 49 | 29 | 16 | 94 |
| Federal Government | 10 | 9 | 17 | 3 | 29 |
| Industrial | 24 | 22 | 6 | 2 | 30 |
| State & Local Government | 17 | 4 | 4 | 10 | 18 |
|  |  |  |  |  |  |
| Subtotal | 114 | 84 | 56 | 31 | 171 |
| 
May possess |  |  |  |  |  |
| CLIA certified complex testing | 8 | 3 | 0 | 6 | 9 |
| 
Least likely to possess |  |  |  |  |  |
| CLIA certified non-complex testing | 0 | 0 | 0 | 0 | 0 |
| 
Total | 
122 | 
87 | 
56 | 
37 | 
180 |

- Types of materials retained*

- * As of November 2003

## Post-survey literature search

- To confirm that all institutions/laboratories publishing on wild poliovirus materials are on the National Inventory
- To identify laboratories publishing on infectious agents that share common enteric origins or replicate on poliovirus-permissive systems.

## Selected PubMed Literature Search2002 & 2003Bacterial and Viraln = 1906

- <date/time>

_**Selected PubMed Literature Search**_**2002 & 2003****Bacterial and Viral****n = 1906**

## Sensitivity of search of >12,000 citations (1993-2003)

| Category  | Inventory | Search | Percent |
| --- | --- | --- | --- |
| Academic | 71 | 51 | 72 |
| Fed. Gov. | 10 | 5 | 50 |
| Industry | 24 | 6 | 25 |
| State & local | 17 | 2 | 12 |
| Totals | 122 | 64 | 52 |

## Institutions publishing (1993-2003) on any poliovirus and not listed on survey database

- 1 community college, environmental project now discontinued
-  1 biotech startup, now defunct

## Institutions publishing (1993-2003) on associated viruses and not listed on survey database

- 1 water service Co. R&D lab
- 2 non-profit foundation laboratories
- 1 community college
- 2 biotech startups, 1 now defunct

## Summary (Phase I)

- The US national survey of >32,000 institutions and >105,000 labs is complete.
- The quality and completeness of the survey is validated by a10 year literature search
- The National Inventory consists of 122  institutions with180 labs.
- Recommendations for Phase II are made and responsibilities defined in the Report

## Acknowledgements

- Kim Koporc (TFSCD), Sandra Browning and Alison Mawle (CDC)
- CDC advisors and support staff
- Departments of the Executive Branch
- Thousands of administrative and lab staff
- NVAC Polio Laboratory Containment Workgroup

## Next steps

- HHS submits Phase I report to PAHO
- US begins planning for Phase II

## Wild Poliovirus*, 24 Dec 2002 to 23 Dec 2003

- <date/time>

**Wild Poliovirus*, 24 Dec 2002 to 23 Dec 2003**

- Data in WHO HQ as of 23 Dec 2003

- *Excludes viruses detected from environmental
-  surveillance and vaccine derived polio viruses.

- The boundaries and names shown and the designations used on this map do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries.  Dotted lines on maps represent approximate border lines for which there may not yet be full agreement.
-  WHO 2003. All rights reserved

- Case or outbreak following importation