# Presentation: 571372

## caDSR Content User’sMeetingConceptual Domains and Value Domains

**Denise Warzel, CORE Infrastructure Program Manager**
**caDSR Product Meeting**
- Aug. 25, 2008

## What problem are we trying to address?

- Simplify Curation capability to help find appropriate Value Meanings
- Simplify the ability to find equivalent CDEs
- Simplify the ability to combine data when two CDEs are ‘semantically equivalent’
- Simplify assessing ’conformance’ by building relationships between CDs and VDs
- Consistent, unambiguous, computable transformations
- Same set of Value Meanings  automate a transformation of the instance data

## Using Conceptual Domain to Organize Value Domains

-  The semantic portion of a Value Domain is the **Value Meaning**
** ****Value Meanings can be **associated with 1 or more Conceptual Domains
-  Value Domains are associated with 1 Conceptual Domains
-  Data Element Concepts are associated with 1 Conceptual Domain
-  Conceptual Domains contain **1 or more **Value Domains
-  A Value Domain may be associated with other Value Domains, via the Value Domain Relationship.

## DE/DEC/CD/VD Metamodel Region of 11179

-  The Conceptual Domain helps by to organize content by grouping **Value Meanings for searching and creating new VDs**
-  The DEC group related DEs
-   The CD addresses the REPRESENTAITONAL CHARACTERISTICS of CDE
-  The DEC addresses the CONCEPTUAL ASPECTS of CDE

## Conceptual Domains and Value Domains

- Conceptual Domains (CD) can be viewed as code sets
- A Value Domain describes a *physical representation* for the Conceptual Domain
- All the Value Meanings in the Conceptual Domain should be included by every Value Domain associated with the CD
- If not, the VD is a ‘subset’ of the CD, and a new CD would be created to hold the new VD.
- Every VD created from the Value Meanings associated with a particular CD would be created as part of the CD, if all VMs are utilized, or in a new, child CD and the VMs associated with the CD
- Optinally, a VD could be made as a ‘child’ of a particular VD, its CD a child of the partent VD’s CD
- A VD may be associated with other VDs

## 1 CD = Anatomic Structure, System or Substance 2435011v1.0

- 31 VDs, 15 DECs, 22 CDEs – Are the CDEs “equivalent”?

## Anatomic Structure System or Substance 22 Data Elements

## VD = Cell Specimen Text Type 2547802v1.1

- _Value_
- Cryopreserved Cells
- Fixed Cell Block
- Frozen Cell Block
- Frozen Cell Pellet
- Not Specified
- Slide

- _Value Meaning_
- Cryopreserved Cell
- Fix Cell Blocks
- Frozen Section Cell Blocks
- Frozen Section Cell Pellet  Formation
- Unspecified
- Slide

- _Concept Code(s)_
- C19314
- C52253:C12508:C25436
- C49338:C12508:C25436
- C49338:C12508:C45813
- C38046
- C25325

## VD = Cell Specimen Text Type Code xxxxv1.1

- _Value_
- CC
- FxCB
- FSCB
- FCP
- NA
- S

- _Value Meaning_
- Cryopreserved Cell
- Fix Cell Blocks
- Frozen Section Cell Blocks
- Frozen Section Cell Pellet  Formation
- Unspecified
- Slide

- _Concept Code(s)_
- C19314
- C52253:C12508:C25436
- C49338:C12508:C25436
- C49338:C12508:C45813
- C38046
- C25325

## VD = Cell Specimen Text Type 2547802v1.1

- _Values from CDE2/VD2_
- CC
- FxCB
- FSCB
- FCP
- NA
- S

- _Values from CDE1/VD1_
- Cryopreserved Cells
- Fixed Cell Block
- Frozen Cell Block
- Frozen Cell Pellet
- Not Specified
- Slide

- _Concept Code(s)_
- C19314
- C52253:C12508:C25436
- C49338:C12508:C25436
- C49338:C12508:C45813
- C38046
- C25325

## Discussion?

- Double check: SIW/Loader selection of DEC CD, should be walking the NCI Thesaurus tree to the highest level concept, and picking the CD in caDSR associated with that “Root Concept”
- What use cases are supported?
- Curation – finding appropriate Value Meanings or existing VDs
- Discovery – what CDEs are equivalent?
- What is the impact on Representation Term for VDs?
- No impact – still qualify Rep Terms if needed to clarify the Rep category, sometimes the Rep term and Property are redundant, its okay, drop the redundant term from the name
- Relationship between CD and VD parent/child – sub-setting can be ambiguous, will need to define business rules