BEE-spoke-data/govdocs1-by-extension huggingface dataset:
# Presentation: 686295

## Sustainability

**Sustainability**

## Slide 2

## Priority Tier I

_**Priority Tier I**_
**Fully fund Title V**
**Support Newborn **
**Screening**

_**Priority Tier II**_
**Universal health care**
**Repeal Medicaid Rules**
**Autism & other DD**
**Preventive Health**
**Services Block Grant**
**Childhood obesity**
**Injury**

##   $850 FFY09 Ask

**  ****$850 FFY09 Ask**
** ****-$666 FFY08 Get**
** ****---------**
** ****+$184 Increase**

**Where should we cut?**
**What would you do **
**with $184 million?**

## Slide 5

**Notes:**
Title V programs touch the lives of 63% of all pregnant women in the United States and 1/3 of all America’s children.

## Slide 6

**Notes:**
Title V programs touch the lives of 63% of all pregnant women in the United States and 1/3 of all America’s children.

## for

**for**
**health**

**Notes:**
Title V programs touch the lives of 63% of all pregnant women in the United States and 1/3 of all America’s children.

## Election year politics

**Election year politics**
**Appropriations process**
**Discretionary squeeze**

**Some successes**
**Stories matter**
**Demonstrate impact**

## Politicians care about public health when it is made real.

**Politicians care about public health when it is made real.**
**You are constituents.**

**Show them why **
**this matters.**

## When we ask, we mean it.

**When we ask, we mean it.**
**We need you!**

**Don’t let this happen **
**to us!**

## 1

## Who is the best advocate for sustaining MCH Training Programs?

**Who is the best advocate for sustaining MCH Training Programs?**
**You are!**

## Walking into a Member’s office and talking about your program is not lobbying.

**Walking into a Member’s office and talking about your program is not lobbying.**
**Asking for money is.**

**Educating & informing is different from asking.**

## Stop talking to 

**Stop talking to **
**ourselves**
**Get to new **
**partners**

**Tell the story – tell it well**
**Make impact real**
**Who else can amplify your message?**

## Slide 15

## Slide 16

## Slide 17

## Slide 18

## Who is the best advocate for sustaining MCH Training Programs?

**Who is the best advocate for sustaining MCH Training Programs?**
**You are!**

## Thank you!

**Thank you!**
# Presentation: 245946

## NGS INTERNATIONAL PROGRAMS

- Agency for International Development
- Federal Aviation Administration
- Individual Countries

## NGS INTERNATIONAL PROGRAMS

- 1993 – Pacific Island Airports
- 1994-1995 – Romania
- 1996 – Caribbean Airports
- 1999-2001 – Hurricane Mitch
- 2004 – Cayman Island, British Virgin   	  	     Islands, Costa Rica, Ethiopia, Iraq, 	     Suriname, Turks & Caicos
- Future – AFRICA CORS

## NGS INTERNATIONAL PROGRAMS

- 1993 – Pacific Island Airports

- Sponsored by FAA
- Airport Surveys for:
- American Samoa
- Guam
- Northern Marianas – Rota, Saipan, Tinian
- Palau
- Federate States of Micronesia – Kosrae, Pohnpei, Chuuk,
-                                               Yap
- Marshall Islands - Majuro

## NGS INTERNATIONAL PROGRAMS

- 1994-95 – Romania

- Sponsored by USAID
- Romania Institute of Geodesy, Photogrammetry and
-       Cartography – IGFCOT
- Provide GPS technology
- Contemporary geodetic capacity building
- Observe 7 station GPS network
- Workshops
- Regional Geodesy Conference

## NGS INTERNATIONAL PROGRAMS

- 1994-95 – Romania

- Ed Allen, Roy Anderson, Ken Bays – BLM, Juliana Blackwell
- Ed Carlson, Charlie Challstrom, Dave Conner
- Davey Crockett, Dave Doyle, Kendall Fancher
- Lucy Hall, Mary Hartell – BLM, Terry Laydon,
- George Leigh, Cliff Middleton, Steve Randall,
- Renee Shields, Bill Stone, Maralyn Vorhauer

## 1994-95 – Romania

**OSORHEI**

**SIRCA**

**MOSNITA**

**SF GHEORGHE**

**STANCULESTI**

**DL PISCULUI**

**CONSTANTA**

## NGS INTERNATIONAL PROGRAMS

- 1996 – 19 Caribbean Island Airports

- Sponsored by FAA, Airlines, and Individual Countires
- American & American Eagle
- British West Indies Airlines (BWIA)
- Leeward Island Air Transportation (LIAT)
- Suriname Air

## NGS INTERNATIONAL PROGRAMS

- 1996 – 19 Caribbean Island Airports

- Install PACS & SACS
- Local network ties
- Limited GPS training of local surveyors

## NGS INTERNATIONAL PROGRAMS

- 1999-2001 – Hurricane Mitch
- El Salvador
- Guatemala
- Honduras
- Nicaragua

## NGS INTERNATIONAL PROGRAMS

- 1999-2001 – Hurricane Mitch
- Install CORS
- Observed Honduras HARN
- GPS training for local surveyors

## NGS INTERNATIONAL PROGRAMS

- SURINAME
- Office of Geographic and Land Information Services
- Install 1-3 CORS
- Possible Absolute Gravity

## NGS INTERNATIONAL PROGRAMS

- CAYMAN ISLANDS
- Office Lands and Surveys
- 2 CORS Added

## NGS INTERNATIONAL PROGRAMS

- IRAQ
- 175th Engineer Company
- 6 CORS Added
- 200 Station HARN

## NGS INTERNATIONAL PROGRAMS

- Ethiopia

- Ethiopian Mapping Authority (EMA)
- Install 1-3 CORS
- Co-Process EMA HARN
- GPS Training
- Possible Absolute Gravity

## NGS INTERNATIONAL PROGRAMS

- BRITISH VIRGIN ISLANDS

- Install 1 CORS
- Possible Absolute Gravity
- Geoid Model Integration

## NGS INTERNATIONAL PROGRAMS

- SOUTH KOREA

- National Oceanographic Research Institute (NORI)
- National Geographic Information Institute (NGII)
- LIDAR Training
- CORS Integration
# Presentation: 843829

##                    Water Production of 			Comet C/1999 S4 (LINEAR)

**SWAN observed hydrogen coma of comet C/1999 S4 from end of May through mid August 2000**
**Obtained systematic set of water production rates for this well documented event of complete fragmentation of a cometary nucleus.**
**Total amount of water released: 3.3x10****9**** kg**
**Combining the SWAN measurements  with Hubble observations of the last fragements yields estimate for size of comet: r = 375 m **
**and thus estimate of density:             ******** 15 kg/m****3**

**SWAN observations of Comet LINEAR a month before it disintegrated.**

**Fragments of Comet Linear seen as mini-comets by HST on         5 August 2000.**

**M****äkinen et al.: 2001, Science 292, 1326**

##       UV/EUV Spectral Atlas 670 – 1609Å

- Best ever analysis of the ultraviolet spectrum of the Sun from 670 to 1609 Å
- 1100 emission lines identified
- 150 of these had not been recorded or identified before
- Particular improvement for Å
- Atlas contains spectra of the quiet Sun, a coronal hole, and a sunspot.
- Rich source of new diagnostic tools to study physical parameters in the solar atmosphere.
- Important product both for solar and stellar communities.

**Curdt et al.: 2001, A&A 375, 591**

## Synoptic Imaging of the                                  Far Side of the Sun

**Synoptic maps combining observed magnetic flux from the near-side of the Sun with proxy flux from the far-side inferred from sound travel time analysis**
**Data: medium-l MDI data**
**Technique: two-skip helioseismic holography (Lindsey & Braun, Science 2000)**
**Updated daily on Internet**

##   The Event of 24 September 20014th Largest Proton Storm of the Current Solar Cycle
# Presentation: 334750

## What is different about these pictures?

*¿Qué es diferente en estas dibujos**?*

## An active child is a healthy child.

**An active child**** is a healthy child.**

***El niño activo es un niño saludable.***

## Limit television viewing to 1 hour each day.

***Limita el mirar la televisión a 1 hora por día.***

**Dance to music.**
***Bailar con la música.***

## Toss soft balls or bean bags into a bowl, empty trash can or laundry basket.

***Lanzar bolas suaves o bolsas rellenas dentro de un recipiente, basurero vacío o cesto de ropa.***

## Create an obstacle course. Crawl under tables, jump over pillows, walk between chairs, etc.

***Crear un sendero con obstáculos, gatear debajo de la mesa, caminar entre sillas, saltar sobre almohadas, etc.***

## Make a yarn ball for your child!¡Haga una pelota con lana para su hijo!
# Presentation: 302511

## Optical/IR Observations of GLAST SourcesCharles Bailyn, Yale

## Uses of O/IR Observations

- Identification of new sources
- SED distributions
- Monitoring of time variability
- Several of above

## Uses of O/IR Observations

- Identification of new sources
- SED distributions
- Monitoring of time variability
- Several of above
-    ALL involve time constrained observations
-    e.g. non-classical scheduling

## S.M.A.R.T.S.Cerro Tololo Interamerican Obs.

- 1.5m

- 0.9m

- 1m

- 1.3m

## 1.3m + ANDICAM

- Dual channel O/IR imager (BVRIJHK) – Limiting mag ~22 in optical, ~18 in IR in 30m observation – small FOV.
- Queue scheduling each afternoon (10-20 projects per night); on-the-fly interpolations possible for highest-priority projects
- Processed data available before noon
- ~30% time available to public through NOAO – potential for special arrangements with GLAST (also Gemini queue)

## SMARTS Studies of Optical/IR Counterparts

- GX 339-4

- Cobb et al. 2006

- GRB 060218 = SN 2006aj

- GRB 050730

## Gaps in the “System”

- 3m – 5m telescope with queue-based spectroscopy
- Wide-field (>1 degree) queue-scheduled imaging
- ReSTAR committee now accepting community input: _[http://www.noao.edu/system/restar](http://www.noao.edu/system/restar)_

## Two Approaches to Complementary Multi-wavelength Data

- Centrally coordinated data available to entire community for general purposes – BVRIJHK magnitudes every few days for all LAT “sources of interest”
- Specific programs for specific science goals to be carried out by the proposer

## Two Approaches to Complementary Multi-wavelength Data

- Centrally coordinated data available to entire community for general purposes – BVRIJHK magnitudes every few daysfor all LAT “sources of interest”
- Specific programs for specific science goals to be carried out by the proposer
-     What is the GI program for?
# Presentation: 703071

## Panel 4: What R&D Is Needed To Meet Urban Needs For Meteorological Information

- David Williams
- US Environmental Protection Agency

## Context

- R&D for in the area of urban meteorological information supports a wide range of requirements from:
- Homeland security
- Emergency response
- City and regional planning
- Global change research community

## Question 1: what is needed

- common and general set of building and landcover info for all cities nationwide
- Accurate met. Info (data/models) at         meso   urban   building sale
- Data to confirm advanced modeling tool results (accuracy assessment)

## Question 2: R&D Activities of greatest potential

- Observational data from collaborative field studies
- Oklahoma City, Urban 2000
- Improved parameterization in mesoscale models (e.g. urban canopy parameters) and building-scale computational fluid dynamics (CFD) models
- Fluxnet network, Landscan USA

## Question 3: R&D areas that require attention

- More collaborative work (e.g. Urban2000)
- More urban data covering a wide variety of urban systems (east to west coverage)
- Confirmatory data to validate simulation models (accuracy assessment)
- Development of a National Database of Urban Parameters and landcover

## Question 3: continued

- Finish Landscan USA as soon as possible
- Develop this dataset into a model to determine near-realtime population dynamics
- Incorporate traffic flow to estimate area population densities in discrete timesteps

## Question 4: R&D products ready for transfer

- Advanced urban canopy models
- CFD model results for certain areas (NYC, DC)
- Geospatial data layers contained in the Homeland Security Infrastructure Program (HSIP), formerly NIMA/USGS 133 Urban Areas in the Nunn-Lugar-Dominici Act

## Question 5: How well are current collaborations working

- Field campaigns well organized
- Fluid modeling progressing well
- Organizations such as the Earth Science Information Partnership (ESIP) provides a good framework for urban meteorological information collaboration

## Question 5: (cont) Where more is needed

- No efforts to develop a National Database of Urban Met. Info.
- Need greater access to data
- Need to drive building-scale models with better meso-urban scale wind fields
- Better collaboration between civil agencies and DoD (NGA, NORTHCOM)

## Question 6: are current R&D transfer processes effective

- Better tech transfer between civil and DoD to support urban applications would be beneficial
- A workgroup should be formed to find ways to enable this
- Testbeds – none planned
- OK City and Houston studies provide framework for constructing a testbed

## Conclusion

*Although this work was reviewed by EPA and approved for publication, it may not necessarily reflect official Agency policy*
*Contact: David Williams*
*williams.davidj@epa.gov*
*(919) 541-2573*
# Presentation: 746119

## Chromospheric Heating in the Quiet Sun

**Chromospheric Heating in the Quiet Sun**

*James McAteer**1*
*Supervisors: Dr. M. Mathioudakis**1**, Prof. F.P.Keenan**1*
*Dr P. Gallagher **2**, Dr. D.R.Williams **3**, Shaun Bloomfield **1*

- 3Mullard  Space Science Laboratory,  Surrey, UK

**Notes:**
2nd Year phd , QUB, supervisors
Collaborators - ex QUB, still fellows
Ken - supervisor of dave, peter

## Problem?

**Problem?**

- Thermal
- Radiative
- Mechanical, Electrical, Magnetic

## MHD Waves 

- Assume no gravity, perfectly conducting, compressible, uniform gas in an inhomogenous magnetic field

## Solutions?

- Active Regions / Flares
- < 1 % energy input
- Internetwork Bright Grains
- < 1 % energy input

## Quiet Sun Magnetic Network

- “Magnetism is to astrophysicists what sex is to psychoanalysts” – Henk van de Hulst

- “If the Sun did not have a magnetic field, it would be as uninteresting a star as most night time observers believe it to be”- R. Leighton

## 1) Radial Study

- McAteer *et al., *(2002), ApJ, 587, L165

## Wavelet Analysis

- (A) no time localisation
- (b) no frequency localisation

**Wavelet Analysis**

- Many time series exhibit non-stationary behaviour

## 2) Temporal Study

- Quasi-periodic oscillations
- Wavelet Analysis
- Granular Buffeting
- Wave Packets

**Notes:**
PUT UP WAVELET DIAGRAM

QUASI-PERIODIC NATURE POSSIBLY ARISING FROM INTERMITTENT GRANULAR BUFFETING

FOLLOW WAVE -PACKETS

COMBINE WAVELET ANALYSIS AND FOURIER TRASFORM
                  | 
   PLUS     |  localised in frequency       |  computationally  easy
                  | localised in time                 |
   MINUS  |   smear out frequency           | can lose transient behaviour
                  |  Cone Of Influence 

## 3) Propagating Waves

- Correlate ‘power curves’
- Ca II K3
- H core
- Mg I b2
- Mg I b1 - 0.4Å
- Time lag at maximum correlation

- McAteer *et al., *(2003), ApJ, 567, in press

**Notes:**
DISCUSS POWER D_x0008_CURVE ON OVERHEAD
NOTE  ----- GOOD HEIGHT COVERAGE
	SEVERAL WAVELENGTHS USED

TIMELAG COMBINED WITH HEIGHT ESTIMATION - PROBLEM OF LACK OF KNOWLEDGE OF HEIGHT FORMATION IN MAGNETISED REGIONS

## MHD Mode Coupling

**MHD Mode Coupling**

## Future

- Higher cadence, longer timespan, larger field of view
- Relation to magnetic field strength
- Frequency, duration & amplitude of oscillation
- Height of coupling
- How many NBPs
- How often does mode-coupling occur? 1 per NBP?
- What are the rest of the waves doing
- Downward moving waves
- Very fast & very slow speeds
- What happens in Transition region and Corona?

**email  J.mcateer@qub.ac.uk **
**http://star.pst.qub.ac.uk/~jma/**

**Notes:**
LARGE NUMBER OF NBPS
SECIS BLUE AND RED WING
EXTEND TO TR AND CORONA
COMBINE WITH B-FIELD STRENGTH AND FLUX EMERGENCE, ENHANCED NETWORK
HIGHER CANDENCE TO DECREASE VELOCITY ERROR
FOLLOW LARGER NUMBER OF NBP OVER THEIR ENTIRE LIFETIME IN MORE WAVELENGTHS

MENTION WEBSITE, EMAIL AND OFFPRINTS
?QUESTIONS? OR CHAT AFTERWARDS
TAKE DISC+OVERHEADS+ NOTES
# Presentation: 800469

## FAA’s Transition Strategy for Navigation and Landing Services

- Dave Olsen
- Navigation System Engineer
- Architecture and Systems Engineering

***2003 FRP User Conference***

## RadionavigationTask Force

- Volpe *Vulnerability Assessment of the Transportation Infrastructure Relying on the Global Positioning System*
- Published in August 2001
- DOT Task Force formed to address mitigation measures
- FAA tasked to develop *Navigation and Landing Transition Strategy - *submitted to DOT in August 2002 (faa.gov/asd - Library)

## Transition Strategy Objectives

- Consider current and future navigation services defined in the 2001 FRP
- Consider state of the aviation industry since September 11th
- Create service-based approach to Navaid reductions
- Optimize rather than minimize services
- Emphasis on  operational readiness, dispatch capability and the servicing of demand
- Continue to recognize differing aircraft equipage *(GA and Air Carrier)*

## Transition StrategyParticipants

- FAA
- NAS Architecture (ASD)
- Regulation and Certification (AFS & AIR)
- Air Traffic Services (AT & AF)
- Focused briefings were presented to:
- Industry groups and trade associations
- DOT (Pos/Nav Executive Committee)
- DoD (Policy Board on Federal Aviation)

## Stakeholder Comments

- Industry
- Airlines and GA
- MITRE/CAASD analysis and support
- Analyzed proposed minimum operating network (MON)
- Sponsored Industry Day – May 7, 2002
- Comments considered in the Transition Strategy

## Satellite NavigationServices

_*GPS and Augmentations*_
- Global Positioning System (GPS)
- Augmented for Accuracy, Availability, Continuity, Coverage, and Integrity
- Wide Area Augmentation System (WAAS)
- Local Area Augmentation System (LAAS)
- WAAS procedures with vertical guidance begin in 2003
- LNAV/VNAV
- LPV

## Projected Navaid Services Transition

**Projected Navaid Services Transition**

## Current VOR Coverage

**1005 VOR/VORTAC/VOR-DME 5,000’ AGL (75nmi radius)**

**Current VOR Coverage**

## Projected MON

**Projected MON**
**VOR Coverage**

## GPS Backup Equipage 

## Architecture & Loran-C

- Ongoing research
- FAA & Coast Guard
- Will Loran support:
- Aviation nonprecision approach?
- Maritime harbor entrance and approach operations?
- Time and frequency users?

## Summary

- FAA Has Proposed a Transition Strategy that considers:
- GPS vulnerability
- Backup requirements
- Strategy is being incorporated into the 2003 Federal Radionavigation Plan
- Opportunity for continued discussions with aviation community

- The more we keep, the greater the cost...
# Presentation: 424710

## Shallow Subsurface Characterization with Transient EM

- Justin A. Bartlett
- The WAG’ers (Team 4)
- 17 July 2002

## The Next Twelve Minutes of Your Life

- Inversions: 3-4 and 15 layer models
- Data masking
- Sensitivity analysis
- Model results
- Model interpretation
- Porosity calculation
- Conclusions

## Initial Inversions

## Masked Data

## Secondary Inversions

## Sensitivity Analysis

## Tertiary Inversions - More Accurate Model

## Smoothed Fit of Stitched 1-D Inversions

## Addition of Three and Four-Layer Models

## Model Summary

- Conductive (18 ohm.m) surface layer about 15 m thick.
- Resistive (101 ohm.m) layer extending to approximately 100 m depth.
- Water table not visible at its reported depth of ~45 m (from well data).
- Layer of increasing conductivity with depth (from 19 to 13 ohm.m).
- Distinct layers break down towards river in smoothed model.

## Explanations

- High conductivity of shallow surface layer results from water evaporation/salt deposition.
- Resistive layer likely sand aquifer but could also be thin layer shown in refraction model.
- Water in resistive layer fresh and therefore not detected by TEM.
- Deepest layer conductive due to higher clay content and/or increased salinity.

## Porosity Methodology

- Archie’s Law: 0 = aw-m
- Applicable only in clay-free sediments
- Assumed a=1, m=2 (uncemented sand)
- Resulting Equation:  = (0 / w ) -1⁄2
- Substituted TDS from well log into nomagram to obtain value for w.
- Average 0 calculated from four-layer models.

## Porosity Results

-  = (0/w ) -1⁄2 = (101/14) -1⁄2  = 37%
- Uniform Sand: 30-40%
- Silt/Clay: 40-55%
- Porosity of deepest layer calculated to be 103% (most likely incorrect).
- Reasons for error:
-    -Presence of clay
-    -Incorrect salinity value

## Conclusions

- TEM data allowed for interpretation to roughly 300 m depth.
- Three distinct layers:
-    1. Near surface conductor
-    2. Resistive layer to ~100 m
-    3. Increasing conductivity in third layer
- All layers uncemented or loosely cemented tertiary sediments with varying clay content/salinity.

## Conclusions (Continued)

- Water table located in resistive layer.
- Resistive layer likely sand aquifer  containing fresh water.
- Porosity of resistive layer calculated to be 37%, a typical sand porosity.
- Line does not cross fault, but effects of fault might be visible at line’s end.
- Finally, I’m serious about the sunscreen.
# Presentation: 264482

## Grease Pressure Release Gun

- patent pending SPEI-00981334

## Step 1

- Before attaching gun to nipple press button home

## Step 2

- Fully connect pressure release gun to nipple

## Step 3

- If the grease is under any pressure the button will move outwards to indicate this pressure and relieve the grease from under the shroud

## Step 4

- Push button in again, this will dispense grease from under the shroud.
- If pressure remains the button will move outwards indicating pressure present.

## Step 5

- If the button doesn’t move and there's no grease discharging from the shroud, it can be considered that there is no pressure at the grease point

- When working on grease system always proceed with care and verify the operation of the grease pressure release gun on test block frequently
# Presentation: 771137

## NDA 50-772 TLC D-99Doxorubicin HCL Liposome The Liposome Company, Inc.

**Proposed Indication: **
**“****First line treatment of metastatic breast cancer in combination with cyclophosphamide”**

## TLC D-99 Review Team

## Administrative History

- 11/24/87		IND # 30,894 submitted
-     2/4/94		End of Phase II meeting
-   6/30/98		Guidance meeting							(Study 2 closed)
-   11/3/98		Study 3 included as a supportive 					trial
- 12/14/98		NDA submitted

## In 1994 the Agency agreed to:

**Utilize response rate as the primary basis of efficacy comparison.**
**Utilize proportional analyses rather than absolute increments (15%). **
**Evaluate response rates using 95% C.I. of the odds ratio.**
**Utilize 1-sided C.I. for this response comparison.**
**Utilize a lower bound of this C.I. (R = 0.75) **

## Administrative History

**June 30,1998****	****	****Guidance meeting ****	****	****	****	****	****(Study 2 closed)**
**Nov 3, 1998****	****	****Study 3 included ****	****	****	****	****	****as a supportive trial**
**Dec 14, 1998****	****	****NDA submitted**

## Study Design and Endpoints

## The dose of epirubicin used in study 3 has not been established equivalent to doxorubicin for the following reasons:

- Doses of 100 to 120 mg/m2 have been used in combination therapy and were more effective than the lower doses.
- Epirubicin may be not equivalent to doxorubicin on a mg per mg basis.
- Epirubicin at 75 mg/m2 has not been demonstrated to be a standard treatment for first line metastatic breast cancer.

## Survival CurveEpirubicin Study 

**Survival Curve**Epirubicin Study

## Efficacy Results Studies 1 and 2 

## Survival Studies 1 and 2

## Study 1Survival

## Study 2Survival 

## Study 2Multivariate analysis

- Prognostic factors for covariate adjustment : 		(J Clin Oncol 16:2401-2408, 1998)
- Disease Free Interval
- AST level
- Liver metastases
- Previous adjuvant chemotherapy
- Treatment effect with covariates: 	 Risk Ratio:** **0.70**	****         **p-value :0.034
- Covariates adjustment for progesterone and estrogen  receptors:  p-value 0.05

## Time to Progression Studies 1 and 2

## Efficacy ResultsStudy 3

## Survival Study 3

## Time to ProgressionStudy 3

## SummaryStudy 3

- Similar response rates and survival
- Trend toward longer TTP for TLC arm
- Relatively low dose of Epirubicin
- Small study stopped prematurely

## Cardiotoxicity

## Summary of Toxicities

## Regulatory issues

- Studies 1 and 2 showed less cardiotoxicity TLC arm
- Non-inferiority (Ratio of Response Rates):
- Study 1: 0.78
- Study 2: 0.62

## Regulatory issues

**Overall survival:**
- Study 1: HR: 1.01    95% CI: 0.71
- Study 2: p= 0.07 HR: 0.75    95% CI: 0.54
- The comparator arm on Study 3 is not adequate

## Reviewer Conclusions

- Insufficient evidence to support TLC D-99 for first line treatment of metastatic breast cancer
- Non-inferior R.R in Study 1
- Negative Survival trend Study 2
- Study 3 inadequate comparator
- TLC D-99 less cardiotoxic, but this endpoint alone does not support the proposed indication

## Slide 24
# Presentation: 743339

## Seamless Internet Integration to Space

- Dave Israel
- NASA/GSFC Code 567.3
- dave.israel@gsfc.nasa.gov
- June 27, 2001

## The Goal - Seamless IP to Space

**The Goal - Seamless IP to Space**

**The goal is for connectivity to spacecraft to be as seamless as any other Internet connection (for authorized users).**

**IP Network**

- D. Israel GSFC/567.3

## SPTR IP Connection

**SPTR IP Connection**

- D. Israel GSFC/567.3

## Connectivity Example

**Maximize use of commercial hardware and software standards**
**Satellite ground stations have their own standards requiring some adaptations on both ends**
**Example:  The Ground Station Router Interface Device**

**Antenna**

**Ground Station**
**RF Equipment**

**Ground Station**
**Router Interface Device**
**(GRID)**

**Router**

- Ground Station LAN

- D. Israel GSFC/567.3

## GRID Stitches the Seam

**GRID Stitches the Seam **

**Downconvert**

**Receiver**

**Demod**

**Bit sync**

**Upconvert**

**Transmitter**

**Modulator**

**Antenna**

**Existing RF **
**Equipment**

- D. Israel GSFC/567.3

## SPTR Additions to White Sands

**SPTR Additions to White Sands**

- D. Israel GSFC/567.3
# Presentation: 007648

## NIH Campus, Bethesda, MD

- _SIMBIOS: Physics-Based Simulation of Biological Structure_
***“******Simbios and SimTK: Physics-Based Modeling”***
- An overview of research at Simbios, followed by a Roundtable discussion
**9:00 a.m. – 10:30 a.m.**
**Natcher Conference Center, Room G1/G2**

**NIH Campus, Bethesda, MD**
**Lister Hill and Natcher Conference Centers, July 17-19**

***For contacts, details and other information visit ***_[http://www.bisti.nih.gov/ahm2006/](http://www.bisti.nih.gov/ahm2006/)_

- _CCB: Center for Computational Biology_
***“******Computational Tools for Representation and Analysis of Biological Shape, Form, and Size”***
- A tutorial session on Computational Neuroscience
**9:00 a.m. to 12:00 noon**
**Lister Hill Visitors’ Center**

- _i2b2: Informatics for Integrating Biology and the Bedside_
***“******Harnessing the Health Care Enterprise for Translational Research in the Genomic Era”***
- A seminar and discussion with Center Director, Dr. Zak Kohane
**9:00 a.m. to 10:30 a.m.**
**Natcher Conference Center,  Room C1/C2**

- _NAMIC: National Alliance for Medical Imaging Computing_
***“******3D Slicer Training Workshop”***
- A workshop on learning to use 3D Slicer, a tool for Diffusion Imaging Analysis and Visualization
**9:00 a.m. – 5:30 p.m.**
**Lister Hill Auditorium**

- _MAGNet: National Center for Multi-Scale Study of Cellular Networks_
***“******geWorkbench: An Interoperable Platform for Integrated Genomics and Systems Biology”***
- A presentation and demonstration by Center Director, Dr. Andrea Califano of (1) the genomics and analysis tools developed by the Center and (2) geWorkbench, the Center’s bioinformatics platform
**9:00 a.m. – 12:00 noon**
**Natcher Conference Center, Room A**

- _NCIBI: National Center for Integrative Bioinformatics_
- “***Computational Systems Biology to Accelerate Research in Complex Disease Applications: 1) Cellular mechanisms of oxidative damage in Diabetes Mellitus complications; and 2) Prostate Cancer”***
- Tutorial sessions with follow-on discussions given by NCIBI senior scientists and selected collaborators
**9:00 a.m. to 12:00 noon**
**Natcher Conference Center, Room F1/F2**

- _NCBO: National Center for Biomedical Ontology_
***“******Ontology: A Vision for the Future and Its Realization” ***
- Presentations and discussion on biomedical ontologies, led by Center Director, Dr. Mark Musen, and Dr. Barry Smith, Lead Investigator of Ontology Best Practices and Dissemination Core
**9:00 a.m. – 12:00 noon**
**Natcher Conference Center, Balcony A**

- Individuals with disabilities who need sign language interpreters and/or reasonable accommodation to participate in these  events  should contact Jennifer Villani at 301-451-6446 or _[villanij@mail.nih.gov](mailto:villanij@mail.nih.gov)_ or through the Federal Relay 1-800-877-8339. Requests should be made at least five days in advance of the meeting.
# Presentation: 748942

## NCS One-Stop Shop Services

**Notes:**
The NCS is experimenting with a One-Stop Shop service to provide a single point of contact to better manage inquires or requests for support from the various NCS-sponsored programs.

At present, each program has an program office with assigned telephone numbers, web sites or e-mail addresses.

A requestor would need to know the contact information to reach a program of choice.

## Consolidate operational support for all of NS/EP telecommunications services

Establish a One-Stop Shop Service for NCS customers:

 to order priority telecommunications services

 to receive coordination/help-desk/information-sharing services and operations

**Establish a ****One-Stop Shop Service**** for NCS customers:**
** ****to order priority telecommunications services**
** ****to receive coordination/help-desk/information-sharing services and operations**

**One-Stop Shop Services Concept**

**Notes:**
The One-Stop Shop concept will
Consolidate operational support for all the telecommunications services within one Division
Provide a single contact source for requestors
Provide a variety of support services to NCS customers

## One-Stop Shop ServicesTelephone Connectivity

**One-Stop Shop Services Call Center**

**Dial into one number with announcements ****	****and multiple service selections. **
***“******For GETS... Press 1”         (703) 676-2037***
***“******For WPS ... Press 2”          (703) 676-6338***
***“******For TSP ... Press 3”           (703) 607-4933***
***“******For Shares ... Press 4”       (703) 607-4963***
***	***
***“******For ENS Pilot ... Press 5”  (703) 676-2350***
***“******For NCC Watch ...Press 6”***
***	******	******	******           ******(703) 607-4950***
***“******For Additional Info ...Press 0”***
***                                                 ******(703) 676-2372***

- Dial:  1-866-NCS-CALL (866-627-2255) 	        or
-                (703) 676-2255
**  *****“******Welcome to the NCS One-Stop Services Directory...”***

- INCOMING

- Rapid  re-termination
-  programming for deployments

## Slide 4

**Notes:**
Are there any questions about this new service or any of the briefings that were presented today.  

If not, we have reached the end of this seminar.  Thank you for this  opportunity to visit your Region and share information about the NCS and the programs it provides for the emergency response community.
We also thank FEMA for providing the use of this training facility and all the other support services.

Please remember to use the Critique Sheets to provide your comments about presentations on today and yesterday.  A drop box will be positioned near the exit door to receive the Critique sheets and your plastic ID Badge.
The PowerPoint files for these briefings will be available for downloading from the NCS web site by the end of the month.  Use the instructions inside the rear cover to find the files.
Also, copies of the Point of Contact roster will be available for you to pickup as you depart.
# Presentation: 948711

## Department of Energy

**The Fourth “R” **
**and**
**Other Pay Flexibilities**

## Recruitment & Relocation Bonuses

- Departmental Elements have delegated authority consistent with 5 CFR
- Utilized conservatively for hard-to-fill locations and special situations, e.g., part of Executive level compensation packages & critical technical positions

## Retention Allowances

- Departmental Elements have delegated authority consistent with 5 CFR
- Utilized conservatively; primarily used at senior & executive levels
- Used effectively to retain Facility Reps in some locations; amount is based on the class of facility involved
- Used selectively by closure sites, including group allowances; special authority to 30% not used yet

## Repayment of Student Loans

- Departmental Elements have delegated authority consistent with 5 CFR
- Elements must establish their own plans based on Departmental plan, guidance, and required service agreement
- 3 Elements have established plans
- 1 Element hired 5 of 8 technical interns using this authority Sep 01

## Repayment of Student Loans

- 	Factors for Selecting All Candidates
- Diversity needs (required criteria)
- Past recruitment problems
- Labor market conditions
- Special qualifications

## Repayment of Student Loans

- 	Factors for Selecting All Candidates
- Appropriateness of this incentive in lieu of, or in addition to, 3Rs
- Availability of funds
- Grade point average (GPA)

## Repayment of Student Loans

- 	Factors for Selecting Employed Candidates
- Demonstrated proficiency performing tasks & functions required
- Cost of training already provided vs what would be needed

## Repayment of Student Loans

-     Factors for Determining Size of Payments
- Availability of funds
- Relative value of candidate; if equal value, then
- Pay the same % of student’s total obligation;
- Pay the same % of student’s monthly payment; or
- Pay the same $ amount; may vary each year depending on budget
- up to the maximum allowable

## Repayment of Student Loans

- 	Options for Determining Service Period
- 3 years service for each year paid
- 3 years service plus 1 additional year for each year paid beginning year 4
- Based on the loan amount: up to $18,000 – 3 years; 1 additional year for each $6,000
- Convert the loan amount to years (3 methods) to determine period of service

## Repayment of Student Loans

- 	Documentation Needed
- Management’s justification
- Information on loan (employee provides for verification by HR or admin staff)
- FMS Form 2231 “Faststart Direct Deposit” for each loan
- Signed service agreement with employee & management certifications
- Annual re-certifications

## Repayment of Student Loans

- 	Payment Options
- Lump sum net annual payments
- Biweekly payroll deductions

## Administrative Flexibilities Guide

- For managers & staff administrators
- Available at: _http://www.ma.mbe.doe.gov/pol/adflex.pdf_
# Presentation: 638212

## Measuring Improper Payments in the Child Care Program:  A Pilot Project of the ACF/Child Care Bureau

- Mary Jo Thomas
- Team Leader
- Intergovernmental Personnel Act Executive

## Why have a pilot project?

- Improper Payment Information Act of 2002 (IPIA)
- Related OMB Guidance
- To discover methods that could help States, Territories and Tribes identify, measure, and prevent errors in the administration of child care funds

## Pilot Project Objectives

- Determine a strategy for estimating improper payments in the Child Care program
- Produce recommendations for improved monitoring and administration regarding improper payments and fraud
- Provide better definitions of child care payment error and child care fraud
- Gather documented “best practices,” plus other technical assistance materials, as well as promising data collection and reporting tools

## Child Care and Development Fund (CCDF) Overview

- Block grant composed of three distinct funding elements (Mandatory, Discretionary, Matching)
- Provides maximum *flexibility for States, Territories and Tribes*
- Provides maximum *choice for parents*

## Flexibility:  Policies vary widely from jurisdiction to jurisdiction

- Eligibility rules for parents
- Amount of co-pay
- Regulation of child care providers
- Waiting lists
- Payment mechanisms
- Locally OR state-administered
- Located in Education Agency OR Social Services Agency OR Workforce Development Agency

## Gathering Perspectives:Pilot Project States

- FIELD SITES
- Arkansas
- Connecticut
- Indiana
- Ohio
- Oklahoma

- PARTNER STATES
- Georgia
- Maryland
- Oregon
- South Carolina
- Virginia*
- Wisconsin
****A shorter site visit was held in Virginia*

## Pilot Project Activities

- Recruitment of Field Sites and other Partners
- Initial Meeting of All Partners in Washington DC
- Field Site Visits
- Regular Communication with Regional Offices and States
- Collaboration with Other Organizations (GAO, United Council on Welfare Fraud, American Public Human Services Association, HHS Office of the Inspector General)

## Outcomes

- Final Report:  September 2004
- Options for Estimating Payment Errors in the Child Care Program
- Options for Improving Program Integrity
# Presentation: 693467

## Module 8B

**A Brief Overview of Specific Mental Disorders and Cross-Cutting Issues:***** ***
***  ***
***Mood & Anxiety Disorders, Schizophrenia & ***
***Other Psychotic Disorders***

## Chapter’s Format

- Disorder category (i.e. Personality, Mood, Anxiety, Psychotic)
- What counselors should know about this category and substance abuse
- Specific disorders within each category
- What counselors should know about substance abuse and the specific disorder
- Diagnostic features and criteria from the DSM-IV-TR
- Case study
- Advice to the counselor

## In This Module . . .

- Module 8A
- Cross-Cutting Issues: Suicidality, Nicotine Dependence
- Personality Disorders
**Module 8B**
- Mood and Anxiety Disorders
- Schizophrenia and Other Psychotic Disorders

- Module 8C
- Attention Deficit/Hyperactivity Disorder (AD/HD)
- Posttraumatic Stress Disorder (PTSD)
- Eating Disorders
- Pathological Gambling
- Appendix D

## TIP Exercise—Assignments

- Group 1—Mood Disorder
- Diagnosis pp. 227–228
- Discussion pp. 226–230; and 369–383
- Group 2—Anxiety Disorder
- Diagnosis p. 230
- Discussion pages *same as Mood Disorder*.
- Group 3—Schizophrenia
- Discussion pp. 231–235; and 385–400

## TIP Exercise—Role Play

*With your group:*
- Review the text’s sections on your assigned diagnosis and related information.
- Create a 3–5 minute role-play script that illustrates key information.
-  A scene likely to play out in your practice
-  All group members must have a role
- Teach us by performing your role play.*	**	**	**        **	**	**	**	**	**	**	**	**	**	**	**                 **(20 minutes**)*
# Presentation: 879828

## Task Order No. I-7“Historical Plankton Data Rescue”

- Todd D. O’Brien
- NMFS Office of Science & Technology
- Marine Ecosystems Division

## Why are historical zooplankton data important?

*Why are historical zooplankton data important?*

- Dramatic changes are occurring _now_ in oceanic ecosystems around the world.  These changes are most visible to the general public as declines (*or even crashes*) in local seabird and fish populations.
- These changes are due, in part, to changes in zooplankton abundance, composition and/or geographic distribution.  Zooplankton, a critical food source for these fish and birds, are in turn responding to changes in local oceanographic conditions.

## How are these historical zooplankton data being used?

- Data rescued by the plankton data project are made freely available online to the scientific community via the global plankton database “COPEPOD” and through various data products and publications.

*How are these historical zooplankton data being used?*

## Project AccomplishmentsCOPEPOD-SAR 2004 – 2008

**Project Accomplishments***COPEPOD-SAR 2004 – 2008*

- Since 2004, CDMP contractors have keyed 308,181 plankton observations collected by 2,365 net tows.  This represents plankton data from 392 cruises around the world, which are now available online and readily useable by the scientific community.

** And the statistics above do not include data from the currently ongoing CalCOFI cards work!*

## The beginning of FY2009 will be spent completing the remainder of the CalCOFI cards (~14 cruises, ~2500 cards).  
The remainder of FY2009 will then continue with a focus on historical plankton data from coastal US waters.

How much more needs to be done on this project?  
At least one more year of work (i.e. FY2010) is possible with already “in-hand” materials and currently identified candidate data sources.
New (old) data sources are continuously uncovered via ongoing library and institutional searches, as well as through direct investigator contact and networking.

- The beginning of FY2009 will be spent completing the remainder of the CalCOFI cards (~14 cruises, ~2500 cards).
- The remainder of FY2009 will then continue with a focus on historical plankton data from coastal US waters.
**How much more needs to be done on this project?**
- At least one more year of work (*i.e. *FY2010) is possible with already “in-hand” materials and currently identified candidate data sources.
- New (old) data sources are continuously uncovered via ongoing library and institutional searches, as well as through direct investigator contact and networking.

## Thank you!CDMP funds bring new life to old data ...

**Thank you!***CDMP funds bring new life to old data ...*
# Presentation: 673700

## Compositeness

- Ulrich Heintz

- International Workshop on Future Hadron Colliders - Ulrich Heintz

- 10/18/2003

## Signals of compositeness

- two signatures
- excited quarks and leptons
- production cross section for jets and leptons
- only considered jets here
- work done at Snowmass 2001

- International Workshop on Future Hadron Colliders - Ulrich Heintz

- 10/18/2003

## Excited quarks

- production
- q + g  q*
- q + q’  q’’ + q*
- decay
- q*  g + q
- q*   + q
- q*  W + q
- q*  Z + q
- simulation: pythia

- International Workshop on Future Hadron Colliders - Ulrich Heintz

- 10/18/2003

## Excited quarks

- production cross section in pb
- assume s=200 TeV, 100 fb-1 (1 year @ 1035 cm-2s-1)

| m*
(TeV) | s (TeV) |  |  |  |  |
| --- | --- | --- | --- | --- | --- |
|  | 14 | 28 | 40 | 100 | 200 |
| 0.6 | 3.6£105 | 2.0£106 | 4.7£106 | 3.6£107 | 1.6£108 |
| 1 | 2.8£104 | 1.9£105 | 4.7£105 | 4.1£106 | 1.9£107 |
| 6 | 3.3£10-2 | 6.5 | 40 | 1100 | 7100 |
| 60 | - | - | - | 3.1£10-6 | 5.6£10-3 |
| 100 | - | - | - | - | 1.3£10-5 |

- International Workshop on Future Hadron Colliders - Ulrich Heintz

- 10/18/2003

## Excited quarks

| 2 partons with pT > 10 TeV
in 100 fb-1 at s=200 TeV |  |  |  |
| --- | --- | --- | --- |
| m* | B(gq) | acc | N |
| 60 TeV | 76% | 90% | 510 |
| 70 TeV |  |  | 100 |
| 80 TeV |  |  | 23 |
| 100 TeV |  |  | 1 |
| QCD |  |  | 25k |

- m* = 100 TeV

- m* = 80 TeV

- m* = 70 TeV

- m* = 60 TeV

- International Workshop on Future Hadron Colliders - Ulrich Heintz

- 10/18/2003

## Excited quarks

- effect of resolution
- 5% constant term

- m* = 100 TeV

- m* = 80 TeV

- m* = 70 TeV

- m* = 60 TeV

- International Workshop on Future Hadron Colliders - Ulrich Heintz

- 10/18/2003

## Excited quarks

- perfect resolution

- resolution = 2%

- resolution = 5%

- resolution = 10%

- s = 200 TeV
- 100 fb-1

| s | m* |
| --- | --- |
| 40 TeV | 16 TeV |
| 100 TeV | 40 TeV |
| 200 TeV | 75 TeV |
|  |  |
| assuming perfect resolution |  |

- S/B for 100 fb-1

- International Workshop on Future Hadron Colliders - Ulrich Heintz

- 10/18/2003

## Jet cross section

- = 50 TeV

- = 75 TeV

- = 100 TeV

- International Workshop on Future Hadron Colliders - Ulrich Heintz

- 10/18/2003

## Jet cross section

|  | # events/100 fb-1 |  | S/B |
| --- | --- | --- | --- |
|  | 30<mjj<70 | mjj>70 TeV |  |
| 50 TeV | 15000 | 570 | 43.6 |
| 75 TeV | 8940 | 160 | 11.3 |
| 85 TeV | 8280 | 120 | 7.2 |
| 100 TeV | 7880 | 88 | 3.8 |
| QCD | 7460 | 55 | - |

- LL isoscalar model implemented in PYTHIA Eichten, Hinchliffe, Lane, Quigg (Rev Mod Physics 1984)

- International Workshop on Future Hadron Colliders - Ulrich Heintz

- 10/18/2003

## Conclusions

- sensitivity to quark compositeness
- for s = 200 TeV and 100 fb-1
- excited quarks
- m* · 70 TeV
- jet cross section
-   · 95 TeV

- International Workshop on Future Hadron Colliders - Ulrich Heintz

- 10/18/2003
# Presentation: 757786

## PRV95 Pressure Relief Valve for Aerospace TestingMarotta Scientific Controls, Inc., Huntsville, AL

- Pressure Relief Valve
- The PRV95 Pressure Relief Valve offers high performance with no impact with an ultrasoft opening and closing design.

- Accomplishments
- PRV95 is still in the prototype stage.
- This non-impact, no-oscillation relief valve solves current fluid system pressure problems associated with conventional “pop-type” relief valves.
- The PRV95 establishes Marotta in the pressure relief valve market.
- Marotta has invested $250,000 into the continued development of the PRV95.

- Commercialization
- Marotta ownes U.S. Patent No. 5,078,177 on the PRV95 Pressure Relief Valve.
- The primary target market for the valve is the aerospace industry, applicable to both ground support and flight applications.
- Marotta plans to take the concept and develop it for use with other line media, such as cryogenic service, liquids (water, diesel fuel, etc.) and natural gas.
- The unique competitive advantage of the PRV95 is its no-impact design.
- The valve utilizes a concept known as upstream control for valve positioning, making the valve more stable and exhibiting excellent repeatability and minimal hysteresis.
- The PRV95 is especially desirable when used in oxygen-rich environments where the possibility of an explosion or fire is very high with conventional pop-type relief valves.

- Government/Science Applications
- Applications within the aerospace industry include, but are not limited to, launch facilities, launch vehicles and test facilities.
- Modified versions of the PRV95 will also be applicable for United States Navy and United States Army applications.

- Points of Contact:
-    -  NASA (Commercial Technology Program, 228/688-1929)
-    -  Marotta  (Eric Dukes, 256/971-1200)
-        1995  SBIR Phase II; NAS # 13-672

- Stennis Space Center
- February 2000
# Presentation: 514381

## Introduction to WASP7 Eutrophication Module

- Overview of Variables and Processes Implemented in WASP7 Eutrophication Module

## Good Reference Materials

- Rates, Constants, and Kinetics
- _[http://www.epa.gov/ORD/WebPubs/surfaceH2O/surface.html](http://www.epa.gov/ORD/WebPubs/surfaceH2O/surface.html)_
- Steve Chapra
*Surface Water Quality Modeling*
- James Martin
*Hydrodynamics and Transport for Water Quality Modeling*
- Thomann and Mueller
*Principles of Surface Water: Quality Modeling and Control *

## WASP7 State Variables	

- Ammonia
- Nitrate
- Orthophosphate
- Dissolved Oxygen
- Salinity

- Phytoplankton
- Periphyton
- Particulate Detritus
- Carbon
- Nitrogen
- Phosphorus
- Dissolved Organic Matter
- CBOD (1)
- CBOD (2)
- CBOD (3)
- DON
- DOP

## Eutrophication Diagram

## Processes Considered

- Phytoplankton Kinetics
- Periphyton Kinetics
- Phosphorus Cycling
- Nitrogen Cycling
- Dissolved Oxygen Balance
- Sediment Diagenesis

## Levels of Complexity in Implementing WASP7 Eutrophication Model
# Presentation: 540056

## Controlled Substance Reporting System

**August 27, 2001**

## ARCOS

- Arcos Reporting
- Electronic System (ARCOS II) mandated by Government Paperwork Elimination Act
- ARCOS II will serve as long term reporting strategy
- Reflects drug distribution
- DEA is working with Industry to develop standards for ARCOS reporting

## CSTR vs. ARCOS

- CSTR (Daily Reporting)
- Mechanism to track e-transactions (as opposed to form 222 green copy)
- Not expecting “letter-perfect” accuracy
- Some latency is acceptable (24 hrs)
- _ARCOS II will eventually replace this method..._

## CSTR Formats

- CSTR – Two acceptable methods
- Order transaction + linked record
- Daily summary report

## Discussion