# Presentation: 044301

## Clinical and Translational Science Awards (CTSAs): Building Connections

- February 4, 2009
- National Advisory Council on Drug Abuse

**Barbara Alving, MD, MACP**
- Director
- National Center for Research Resources

**National Center for****Research Resources**

-  NATIONAL INSTITUTES OF HEALTH

* **A **c c e l e r a t i n g   a n d   e n h a n c i n g   r e s e a r c h   f r o m   b a s i c  d i s c o v e r y   t o  i m p r o v e d   p a t I e n t   c a r e*

## National Center for Research Resources 

***Clinical***

***Community***

**National Center for Research Resources**** **
**Accelerating research from basic discovery to improved patient care**

***Improved patient care***

***Pre-clinical***

- Animalmodel resources

- imaging & informatics advances

- Clinicalresearch support

- community engagement

## Impetus for the CTSA Program

**Impetus for the CTSA Program**

**CTSAWeb.org**

- Implement biomedical discoveries
- Develop, test, and bring new prevention strategies into medical practice more rapidly
- Catalyze change - lower barriers between disciplines
- Encourage creative and innovative approaches

- To ensure new discoveries lead to improved public health, clinical science must evolve to better:

## CTSAs – Building a National Consortiumof Academic Health Centers

**Members 2006 & 2007**

**Participating Institutions**

**New Members 2008 **

- CT

- Currently 38 CTSAs Sites Across the Country

## CTSA – Providing Local Leveraging Opportunities

**Atlanta Clinical and Translational Science Institute (Atlanta-CTSI) at Emory University**

**Notes:**
Atlanta CTSI
An inter-institutional partnership between Emory University, Morehouse School of Medicine, Children’s Healthcare of Atlanta, and Georgia Tech. 
The ACTSI focus is on community engagement, training C&T investigators, and reducing health disparities.

The goal is to extend the CTSA philosophy of interdisciplinary interactions and connectivity to generate partnerships and collaboration beyond the consortium to organizations involved with health care throughout the nation. 
It is through multiple partnerships that CTSAs will transform clinical and translational research and bring new scientific advances to health care.

## CTSA – Creating National Partnership Opportunities Consortium Governance

- _[www.ctsaweb.org](http://www.ctsaweb.org/)_** **

**Advisory:** providing guidance and input to the NCRR Director
**Oversight:** identifying and selecting collaborative opportunities to facilitate research, coordinating Consortium-wide approaches to research, and overseeing topic-specific efforts across the Consortium
**Steering:** coordinating institutional topic-specific efforts with the national CTSA Consortium; each Steering Committee has an Operations subgroup that takes timely action on emergent topic issues

## Goal One:
Enhancing National Clinical and Translational Research Capability 
Clinical research management
Research infrastructure
Phenotyping – human and preclinical models

Goal Two: 
Enhancing Training and Career Development of Clinical and Translational Investigators

Goal Three:
Enhancing Consortium-Wide Collaborations
Social networking
Inventory of resources
Data sharing

Goal Four:
Enhancing the Health of Our Communities and the Nation
Community engagement
Public health policy

_**Goal One:**_
**Enhancing National Clinical and Translational Research Capability **
**Clinical research management**
**Research infrastructure**
**Phenotyping – human and preclinical models**
_**Goal Two**__**:**_** **
**Enhancing Training and Career Development of Clinical and Translational Investigators**
_**Goal Three:**_
**Enhancing Consortium-Wide Collaborations**
**Social networking**
**Inventory of resources**
**Data sharing**
_**Goal Four:**_
**Enhancing the Health of Our Communities and the Nation**
**Community engagement**
**Public health policy**

## CTSA – Creating National Partnership Opportunities

- Working as a Consortium, we have established a committee           structure  to execute the vision and goals of the CTSA program

## CTSAweb.org

**Resources for Researchers**
**Building Connections**
**e-Newsletter**
**Communication Toolkit**

## CTSA – Creating Regional Partnership Opportunities 

- Weill Cornell Medical College

- Columbia University

- Rockefeller University

- Albert Einstein College of Medicine

- University of Rochester

- Yale University

- University of Wisconsin

- Mayo Clinic College of Medicine

- University of Washington

- Oregon Health & Science University

- University of California, Davis

- University of California, San Francisco

- Stanford University

- The Scripps Research Institute

- Washington University in St. Louis

- Universityof Iowa

- University of Chicago

## Implementation and development of tools for clinical investigators to facilitate small and medium sized research studies
Enhance the collection and management of data in small and medium sized studies
Requirements
At least three CTSA must collaborate
Data and software sharing
Must incorporate institutional database support that is flexible, secure, and easily accessible on demand

- Implementation and development of tools for clinical investigators to facilitate small and medium sized research studies
- Enhance the collection and management of data in small and medium sized studies
- Requirements
- At least three CTSA must collaborate
- Data and software sharing
- Must incorporate institutional database support that is flexible, secure, and easily accessible on demand

- Clinical and Translational Information Exchange Environment Informatics Pilots

## PhysioMIMI at Case Western Reserve University 
Includes investigators from Marshfield Clinic, University of Wisconsin and University of Michigan
Collects, manages, and analyzes diverse data types across institutions
Allows secure, safe and regulated transfer of information from clinical care systems and research databases

Sharing Clinical Data at University of Washington 
Includes investigators from University of California, San Francisco, University of California, Davis
Allow researchers to access large shared datasets
Assist with designing research studies and generating hypotheses

Research Electronic Data Capture (REDCap) at Vanderbilt
Includes investigators from Oregon Health and Sciences University and Mayo Clinic
Provide an easy way for researchers to develop a secure, web-based application for collecting, managing and sharing of their clinical and translational research data
Create secure and flexible interoperability between REDCap and external data systems thus ensuring data quality in information exchange

_*PhysioMIMI*_* at *Case Western Reserve University
- Includes investigators from Marshfield Clinic, University of Wisconsin and University of Michigan
- Collects, manages, and analyzes diverse data types across institutions
- Allows secure, safe and regulated transfer of information from clinical care systems and research databases
- Sharing Clinical Data at University of Washington
- Includes investigators from University of California, San Francisco, University of California, Davis
- Allow researchers to access large shared datasets
- Assist with designing research studies and generating hypotheses
- Research Electronic Data Capture (REDCap) at Vanderbilt
- Includes investigators from Oregon Health and Sciences University and Mayo Clinic
- Provide an easy way for researchers to develop a secure, web-based application for collecting, managing and sharing of their clinical and translational research data
- Create secure and flexible interoperability between *REDCap* and external data systems thus ensuring data quality in information exchange

## Informatics Pilots

**Informatics Pilots**

- WA

- OR

- CA

- NV

- AZ

- NM

- MT

- UT

- WY

- CO

- SD

- ND

- NE

- KS

- OK

- TX

- AK

- AR

- MO

- IA

- MN

- WI

- IL

- IN

- MI

- OH

- KY

- TN

- MS

- AL

- GA

- FL

- LA

- NC

- SC

- VA

- WV

- PA

- NY

- VT

- NH

- ME

- MA

- DE

- MD

- RI

- ID

- HI

- CT

- NJ

- PR

**University of California, Davis**

**University of California,**** San Francisco**

**Mayo Clinic College of Medicine**

**University of Washington**

**Vanderbilt **
**University**

**Case Western ****Reserve University**

**Mansfield**** ****Clinic **
**University of **
**Wisconsin–**
**Madison**

**Oregon ****Health & Science University**

**University of**
** ****Michigan**

## CTSA Consortium – Building Connections with Business Schools

- Develop business plans, design, and implement community surveys
- Create innovative cross-educational programs
- Develop case studies to pilot programs
- Collaborate with international colleagues
- Prepare cost analyses
- Protect CTSA-developed patents
- Form industry partnership programs

- CTSA are partnering with business schools to:

## Emergency Medicine
Sleep Research Network
Critical Care
Neurology
Neuroimaging 

- CTSA Thematic Research Networks/CTSA Interest Groups

- Emergency Medicine
- Sleep Research Network
- Critical Care
- Neurology
- Neuroimaging

## Educational Impact of CTSA Program

- Doubled the clinical and translational training workforce from 2006 - 2008
- Increased the number of regional training interactions among consortium sites
- Awarded a supplement to develop a National CTSA Educational Resource Program (NCERP) that will:
- Identify, catalog, and assess training modules in clinical and translational research
- Enhance and broaden training opportunities for clinician-scientists across the CTSA consortium

## Educational Impact of CTSA Program (Based on 2008 Annual Progress Reports from first 24 CTSAs) 

## CTSA Consortium and NIDA Collaborations(Based on 2008 Annual Progress Reports from first 24 CTSAs) 

| Columbia University Health Sciences | 8 |  |
| --- | --- | --- |
| Emory University | 1 |  |
| Johns Hopkins University | 19 |  |
| Oregon Health and Science University | 2 |  |
| Rockefeller University | 3 |  |
| University of California San Francisco | 2 |  |
| University of Chicago | 3 |  |
| University of Pennsylvania  | 8 |  |

- NIDA Grants Utilizing CTSAs

**Notes:**
Of theses NIDDK awards over 75% are Research Project Grants (RPGs) including mostly R01s and U01s.

## CTSA Consortium and NIDA Collaborations(Based on 2008 Annual Progress Reports from first 24 CTSAs) 

| University of Texas Health Science Center Houston |  | 3 |  |
| --- | --- | --- | --- |
| University of Texas SW Medical Center Dallas |  | 3 |  |
| University of Washington |  | 1 |  |
| University of Wisconsin Madison |  | 1 |  |
| Vanderbilt University |  | 3 |  |
| Washington University |  | 2 |  |
| Weill Medical College of Cornell University |  | 2 |  |
| Yale University |  | 29 |  |
| Total |                90 |  |  |
|  |  |  |  |

- NIDA Grants Utilizing CTSAs

**Notes:**
Of theses NIDDK awards over 75% are Research Project Grants (RPGs) including mostly R01s and U01s.

## NIDA Clinical Trials Network 

- Established in 1999 to conduct research in a wide variety of community based treatment programs across the United States.
- Provides a unique opportunity to address a variety of underserved populations, and in particular to evaluate access to and effectiveness of treatments for ethnic minorities.
- Seeks to reduce barriers to all its studies and has attended carefully to recruitment and retention of women and ethnic minority groups.

- Clinical Trials Network (CTN)

## Opportunities for Partnership with CTSAs and NIDA Clinical Trials Network

## Funding Opportunities at NIDA

## National Center for Research Resourceswww.ncrr.nih.gov

- Translating Research from Basic Discovery to Improved Patient Care