BEE-spoke-data/govdocs1-by-extension huggingface dataset:
# Presentation: 107990

## Introduction and Unit Overview

- The role of CERTs in fire safety:
- Put out _small_ fires.
- Prevent additional fires.
- Shutoff utilities
- Assist with evacuations where necessary.

## Unit Objectives

- Explain the role of CERTs in fire safety.
- Identify and reduce potential fire risks in the home and workplace.
- Conduct a basic sizeup for a fire emergency.
- Understand basic safety precautions.
- Identify hazardous materials in the home and community.
- Extinguish small fires using a fire extinguisher.

## The Fire Triangle

- Heat
- Fuel
- Oxygen

## Fire Chemistry

- Classes of fire:
- A:  Ordinary combustibles
- B:  Flammable and combustible liquids
- C:  Energized electrical equipment
- D:  Combustible metals

## Reducing Fire Hazards in Home and Workplace

- Avoid the “electrical octopus.”
- Don’t run cords under carpets.
- Replace broken or frayed cords.
- Maintain appliances.

## Reducing Fire Hazards in Home and Workplace

- Install a natural gas detector.
- Locate and label gas shutoffs.

## Reducing Fire Hazards in Home and Workplace

- Read labels.
- Use L.I.E.S. storage procedures (_L_imit, _I_solate, _E_liminate, _S_eparate).

## CERT sizeup

- Answer these questions:
- Can my buddy and I fight the fire safely?
- Do we have the right equipment?
- Are there other hazards?
- Is the building structurally damaged?
- Can we escape?

## CERT Sizeup

- Gather Facts.
- Assess Damage.
- Consider Probabilities.
- Assess Your Situation.
- Establish Priorities.
- Make Decisions.
- Develop Plans of Action .
- Take Action.
- Evaluate Progress.

## Firefighting Resources

- Resources available:
- Portable fire extinguishers
- Wet standpipes
- Confinement
- “Creative” resources

## Types of Fire Extinguishers

- Water
- Dry chemical
- Carbon dioxide
- Specialized fire extinguisher

## P.A.S.S

- _P_ull
- _A_im
- _S_queeze
- _S_weep
- Test the extinguisher before approaching any fire.

## Fire Suppression Safety

- Do:
- Use safety equipment.
- Work in a buddy system.
- Have a backup team.
- Have two ways to exit.
- Maintain a safe distance.
- Overhaul the fire.

## Fire Suppression Safety

- DON’T
- Try to suppress large fires.
- Get too close.
- Fight it alone.
- Enter smoke-filled areas.

## Hazardous Materials . . .

- Corrode other materials
- Explode or are easily ignited
- React strongly with water
- Are unstable when exposed to heat or shock
- Are toxic to humans, animals, or the environment

## Identifying Stored Hazardous Materials

## Identifying Stored Hazardous Materials

- NFPA 704 Diamond-White Quadrant:
**W**  Shows unusual reactivity with water
**OX**  Possesses oxidizing properties

## Identifying Hazardous Materials in Transit

## Identifying Hazardous Materials in Transit

**Name**

**Chemical Class**

**Symbol**
# Presentation: 089821

## Jet Studies in CMSSW_1_3_1

- Agata Smoron
- University of Illinois at Chicago, UIC
- Jet Algorithms Subgroup meeting
- 12.06.07

- Mt. Blanc

## Outline

- Fractional energy resolution plots
- Asymmetry
- Resolutions
- Standard resolution
- Response versus PT
- Response versus rapidity
- QCD 2     2 hard scatters generated by PYTHIA in CMSSW_1_3_1 were used

## Theory behind the resolution

- Fractional energy resolution is:
-  *σ**(E**T**)/E**T**  = √2 **σ**A**,*
- where *σ**A**2* is the variance of asymmetry distribution
- Asymmetry is defined by:
*A = (E**T**jet1** – E**T**jet2**)/(E**T**jet1** + E**T**jet2**),*
- where *jet1* corresponds to the first leading jet and *jet2* to second leading jet

## CaloJet asymmetry, mcone5(10 < Pt < 800, |η| < 1.4) 

## GenJet asymmetry, mcone5 (10 < Pt < 800, |η| < 1.4) 

## Soft radiation correction

- To obtain the true dijet system, the asymmetry was plotted for ETjet3 cuts of 4, 6, 8, 10, 12, 15, 17 and 20 GeV
- Then the resolution was extrapolated to “true” dijet system with ETjet3 = 0 GeV
- The phi angle between the leading jets was restricted to Δφ > 155°

## Resolution as a function of the cut on ETjet3

## Resolution extrapolated to ETjet3 = 0 GeV

## Resolution as a function of average transverse energy: ET = (ET,1 + ET,2)/2 GeV 

- The final resolution is obtained by subtracting the particle level resolution from the reconstructed resolution:
*[**σ**(E**T**)/E**T**]**2 **= [**σ**(E**T**)/E**T**]**2**calo** **+ [**σ**(E**T**)/E**T**]**2**gen*
- And fitted with:
*[**σ**(E**T**)/E**T**]**2** = N**2**/E**T**2** + S**2**/E**T** + C**2 *

## Fractional Energy resolution: σ(ET)/ET as a function of average ET, (mcone5)

## Fractional Energy resolution: σ(ET)/ET as a function of average ET, (icone5)

## Fractional Energy resolution: σ(ET)/ET as a function of average ET, (FastKt06)

## Standard resolution and response plots in CMSSW_1_3_1

- These resolutions were obtained by dividing the sigma of the ratio of reconstructed to generated jets by its min value

## Resolution 

- 600 < PT(hat) < 800

- 170 < PT(hat)< 230

## Response (170 < PT(hat) < 230)CMSSW_1_2_0 corrections were used

## Response versus rapidity (170 < PT(hat) < 230)

- 20 < PT < 25

- 190 < PT < 210

## Conclusion

- The fractional energy resolution have to be redone with the bigger statistics (I’ll take care of this)
- CMSSW_1_2_0 corrections are good for CMSSW_1_3_1 as well
- FastKt algorithm seems to behave correctly
# Presentation: 718618

- LHC Accelerator Research Program
- Beam Instrumentation Summary
- LARP Meeting
- 19-21 October, 2004
- John Byrd

- John Byrd

- LARP Mtg, 19-21 Oct 2004

## LARP will help the LHC in 3 key areas:
Bring LHC to full energy
	Betatron tune, coupling, and chromaticity control during ramp
Bring LHC to design luminosity
	Real-time luminosity monitor
LHC machine protection
	Longitudinal density monitors

*Bring LHC to full energy*
- 	Betatron tune, coupling, and chromaticity control during ramp
*Bring LHC to design luminosity*
- 	Real-time luminosity monitor
*LHC machine protection*
- 	Longitudinal density monitors

- LARP Beam Instrumentation and Diagnostic Techniques

- These contributions advance the state-of-the-art in beam instru-mentation and have direct contributions to present and future US accelerator projects.

- John Byrd

- LARP Mtg, 19-21 Oct 2004

## Budgets

|  | FY04 (k$) | FY05 (k$) |
| --- | --- | --- |
| Tune Control | 138 | 195 |
| Luminosity Monitor | 162 | 395 |
| Abort Gap Monitor | 80 | 0 |

- John Byrd

- LARP Mtg, 19-21 Oct 2004

## Topics for Discussion

- Determine specific criteria for meeting milestones:
- When does luminosity R&D move to production?
- Approach for betatron tune control?
- Budget requirements for FY06 and beyond.
- begin definition of deliverables
- incorporate commissioning manpower needs
- Topics for additional instrumentation:
- Schottky monitors
- AC dipole

- John Byrd

- LARP Mtg, 19-21 Oct 2004
# Presentation: 030708

## University of Chicago MRSEC 0213745 

**University of Chicago MRSEC 0213745 **
**Chicago Networks—Smooth Evolution without Fine-Tuning, Sidney R. Nagel**

- Panos Oikonomou (graduate student shared between **Cluzel** and **Kadanoff**) and **Philippe Cluzel** at the Chicago MRSEC have  demonstrated that the “architecture” or how the components are organized in biological systems govern their ability to evolve [1].  They compare two distinct designs: homogeneous networks which are randomly structured and heterogeneous scale-free networks  for which the distribution of connections follows a power law.
- Their simulations show that populations containing these scale-free networks can easily produce a number of functional variations, but each of these populations evolves smoothly and rapidly towards some same target function.  By contrast, the equivalent random networks evolve slowly, through a succession of rare fortuitous random mutations which requires the invocation of a specific tuning of the connectivity to access the target faster.  This particular type of fine-tuning is not required for scale-free networks, which may account for their ubiquity in nature.

- [1] Effects of Topology on Network Evolution, Panos Oikonomou, and** Philippe Cluzel,** *Nature Physics*, **2** (8): 532-536, (2006).

*Illustration of a scale-free network.  These have a heterogeneous topology characterized by many nodes with a small number of connections and a few highly connected nodes with many inputs or outputs (different colors represent different types of nodes).  The distribution of connections follows a power law.*
# Presentation: 211969

## Carbon Nanotube and Silicon Nanowire Based Quantum 

- Carbon Nanotube and Silicon Nanowire Based Quantum
- Computation, NIRT-0210736

- Top: Schematic of device with 2-nm diameter  SWNT, electrical contacts (Ti/Au) and gates for local control of current flow.
- Bottom: Peaks indicate gate values where charge flows through two neighboring quantum dots. (Mason, Biercuk, Marcus (2003))

*Susan K. Watson, Middlebury College; Charles M. Marcus, Harvard; Charles M. Lieber, Harvard; Leonid I. Glazman, U. of Minnesota; David DiVincenzo, IBM Yorktown*

- Smaller, more densely packed circuits have the potential to revolutionize the electronics industry. As circuit components are pushed into the 1—100 nanometer (nm) size scale, circuits become faster and  behave in novel, non-classical ways.
- Our research is focused on producing, testing, and modeling prototype circuit elements using single wall carbon nanotubes (SWNTs) and silicon nanowires, with the aim of building the functional components of a quantum computer. Here we demonstrate the ability to locally control current flow through two neighboring quantum dots formed in a SWNT, a crucial first step in designing the computing element of a quantum computer.

## Carbon Nanotube and Silicon Nanowire Based Quantum 

- Computation, NIRT-0210736

*Susan K. Watson, Middlebury College; Charles M. Marcus, Harvard; Charles M. Lieber, Harvard; Leonid I. Glazman, U. of Minnesota; David DiVincenzo, IBM Yorktown*

- Education:
- The NIRT project has had a substantial impact on graduate and undergraduate student training. The Lieber group has supported an undergraduate student, Elina Onitskansky, based on the funding from the NIRT project. Elina has worked jointly with an advanced graduate student, Andrew Greytak, and is presently learning all of the state-of-the-art nanofabrication techniques required in this work. In the Marcus group, an undergraduate, Jerry Chow, has worked closely with graduate student Michael Biercuk and post-doc Nadya Mason in developing a new processing technique for creating thin insulating films and a technique for local gating of carbon nanotubes. In the Watson group, two undergraduate students, Mike Ryan and Nathaniel Merrill, completed senior thesis projects on nanotechnology; one undergraduate, Ted Lester, was supported by NIRT funding to conduct research at Harvard this past summer.

- Chow, Marcus (2003)
# Presentation: 718926

## State Pension Benefit Estimates

**David G. Lenze**
*Southern Regional Science Association*
- 1 April 2006

## SNA Treatment

- Primary income of Household Sector
- Employer contributions counted as part of compensation
- Property income of pension funds is counted as part of dividends, interest, & rent

## SNA Treatment

- Disposable Household Income
- Contributions (employer & personal) & Property income deducted
- Benefits added
- Hence:
- Compensation includes contributions, but
- Disposable income includes benefits

## U.S. Pension Benefits (billion $)

- 	_	__	__	__A__	__	__B__	__	__NIPA_
- 	1997		470.9	466.4	390.8
- 	1998		522.7	527.1	397.5
- 	1999		566.1	595.1	424.5
- 	2000		612.6	652.2	453.4
- 	_2001__	__	__644.1__	__709.4__	__484.6_
- A—Using Form 5500; B—Using Form 1099R

## State Pension Estimates

- Source Data
- SOI Division expanded IRMF sample
- 1099-R
- 5498
- ACLI

## Share of Nation—6 largest states, 2000

- _	__	__	__	__ __Pop.  __	__Inc.__	__	__Pens._
- California		12.0%	13.1%	10.7%
- Texas    		7.4  		7.0      	4.9
- New York 	6.7  		7.9      	7.9
- Florida  		5.7  		5.4      	7.8
- Illinois 		4.4  		4.8      	4.1
- _Pennsylvania  __	__4.4  __	__	__4.3 __	__	__4.3__	_

## Per Capita, 2000 ($)

- 				Personal		Pension
- _	__	__	__	__Income__	__	__Benefits_
- DC			40,456		5,385
- Delaware		30,869		4,006
- Hawaii		28,422		3,604
- Maryland		34,257		3,395
- Virginia		31,087		3,320
- Florida		28,509		3,156
- _Maine__	__	__25,969__	__	__1,446__	_

## Adjustments to US Personal Income, 2000 (billion $)

- Personal income			      8,429.7
-  - Net reclassifications			     3.0
-  - Pension contributions			 697.7
-  - Pension Fund Property Income	 367.7
- _ __+ Pension benefits__	__	__ __	__	__ 652.2_
- Cash personal income	              8,013.6

## Do Pension Benefits Contain Information Missed by Personal Income?

- Sales = .85 Personal Income + 12.1
-             (5.75)                            (7.98)
-             R2=0.40
- Sales = .70 Personal + .27 Pension +11.5
-             (4.81)               (2.93)           (8.05)
-             R2=0.49
# Presentation: 813048

## LINAC DESIGN – G.A. May 6,’04

- P.Ostroumov (ANL) Calculations
- Assumptions
- SCRF LINAC starts at 87 MeV
- Axial Transit-time factor in uniform approximation
- Phase=300 for <1, Phase=160 for =1
- 6-cells and 8-cells cavities

## LINAC DESIGN RESULTS

- 6-CELLS
- =0.47		87 –170 MeV	***22 Cavities******	***3 Cryos
- =0.61		170-349 MeV	32 Cavities	4 Cryos
- =0.81		349-1095 MeV	***82 Cells******	******	***11 Cryos
- =1.00(TESLA)	1095-8019 MeV	***316 Cells******	***40 Cryos
- 							**Total****	****58 Cryos**
- 8-CELLS
- =0.47				***18 Cells******	******	***3 Cryos
- =0.61				26 Cells		4 Cryos
- =0.81				***60 Cells******	******	***8 Cryos
- =1.00(TESLA)			***316 Cells******	***40 Cryos
- 							**Total****	****55 Cryos**

## PROBLEMS ?

- Wrong Proton Mass ?
- Actual proton mass is 938 MeV
- Minor problem, changes slightly final energy (by few MeVs)
- TESLA Cavities used always at =1
- Right
- Wrong (?)

## P.O. CORRECTED (?)

- 6-CELLS
- =0.47		87 –170 MeV	22 Cavities***	***3 Cryos
- =0.61		170-349 MeV	32 Cavities	4 Cryos
- =0.81		349-1095 MeV	82 Cavities***	***11 Cryos
- =1.00(TESLA)	1095-8019 MeV	***330 Cavities******	***42 Cryos
- 							**Total****	****60 Cryos**
- 8-CELLS
- =0.47				18 Cavities***	***3 Cryos
- =0.61				26 Cavities	4 Cryos
- =0.81				60 Cavities***	***8 Cryos
- =1.00(TESLA)			***328 Cavities******	***41 Cryos
- 							**Total****	****56 Cryos**

## Playing Along in P.O. Approximations

- 6-CELLS
- =0.47		87 –170 MeV	24 Cavities***	***3 Cryos
******=0.62**		170-352 MeV	32 Cavities	4 Cryos
- =0.81		352-850 MeV	48 Cavities***	***6 Cryos
- =1.00(TESLA)	850-8029 MeV	***380 Cavities******	***48 Cryos
- 							**Total****	****61 Cryos**
- 10-CELLS
- =0.47				24 Cavities***	***3 Cryos
******=0.62**				32 Cavities	4 Cryos
- =0.81				48 Cavities***	***6 Cryos
- =1.00(TESLA)			***330 Cavities******	***42 Cryos
- 							**Total****	****55 Cryos**

## Playing Along in new Scenario 

- (Ein = 130 MeV for Elliptical Cavities)

- 8-CELLS
- =0.57		130 - 302 MeV	32 Cavities***	***4 Cryos
- =0.75		302 - 855 MeV	56 Cavities***	***7 Cryos
- =1.00(TESLA)	855 - 8005 MeV	***358 Cavities******	***45 Cryos
- 							**Total****	****56 Cryos**
- 8-CELLS (P.O. – baseline approach)
- =0.47				18 Cavities***	***3 Cryos
- =0.61				26 Cavities	4 Cryos
- =0.81				60 Cavities***	***8 Cryos
- =1.00(TESLA)			***328 Cavities******	***41 Cryos
- 							**Total****	****56 Cryos**
# Presentation: 412014

## CIVIL AIR PATROL

- Colorado Springs Cadet Squadron
-  Lt Col M. T. McNeely

- TYPES OF ORBITS

-                                                  PRESENTS
-    INTRO TO SPACE COURSE

## TYPES OF ORBITSOVERVIEW

- TYPES OF ORBITSOVERVIEW

- Types of Satellites and their Missions
- Satellite Orbitology
- Satellite Orbits and Mission Contribution

## TYPES OF ORBITS -Uses of Satellites

- TYPES OF ORBITS -Uses of Satellites

- Daily Uses of Satellites
- Big Picture
- Affects of Altitude

## TYPES OF ORBITS -Uses of Satellites

- TYPES OF ORBITS -Uses of Satellites

**GPS Receiver Used in Search and Rescue Missions**

## TYPES OF ORBITS -Uses of Satellites

- TYPES OF ORBITS -Uses of Satellites

**A Remote Sensing Satellite’s view of Earthquake  Damage**

## TYPES OF ORBITS 

- TYPES OF ORBITS

- LEO
- MEO
- HEO
- GEO

## TYPES OF ORBITS 

- TYPES OF ORBITS

- Relating Mission to Orbit Type

## TYPES OF ORBITS 

- TYPES OF ORBITS

- STK Scenarios
# Presentation: 119290

## Tim Marker

- FAA Technical Center

- Development of a Lab-Scale Test For Evaluating Toxic Gas Decomposition Products Generated Inside a Fuselage During a Postcrash Fire

## Fuselage Burnthrough Full-Scale Testing - Background

- Full-sale test article built at FAATC in mid 1990’s for evaluating performance of
- burnthrough-resistant thermal acoustic insulation materials.

- Testing indicated burnthrough-resistant insulation provided a much more survivable cabin
- atmosphere when compared to current insulation materials.

- Although burnthrough resistant materials provide a benefit, the ingress of toxic gases
- resulting from decomposition of the insulation needs to be quantified.

- FAA issued NPRM, 2003 Final Rule issued, 2009 compliance

- 2006 FAATC began development of a lab-scale test for evaluating toxic gas decomposition
- products that could be generated inside fuselage during postcrash fire.

## Apparatus for Evaluating Toxic Gas Decomposition Products

## Apparatus for Evaluating Toxic Gas Decomposition Products

- to collect and measure toxic and flammable gases yielded during tests.

- Burner configuration according to 25.856(b) Appendix F, Part VII.

- Steel cube box simulates intact fuselage and serves as enclosure to collect emitted gases.

- Additional analyzers measured the concentration of total hydrocarbons (THC) as propane,
- carbon monoxide, carbon dioxide, and oxygen

## Slide 5

## Apparatus for Evaluating Toxic Gas Decomposition Products

- sampling ports for gas analysis

## Apparatus for Evaluating Toxic Gas Decomposition Products

## Apparatus for Evaluating Toxic Gas Decomposition Products

- catch pan for melted aluminum skin

## Apparatus for Evaluating Toxic Gas Decomposition Products

- pressure relief device

## Gasket System Used for Securing Test Sample in Enclosure

## Development of Lab-Scale Toxicity Test For

- the new burnthrough test requirements, in order to ensure that an adverse condition will not result inside the fuselage, despite the high burnthrough performance associated with a particular system.

- Decomposition Products During a Postcrash Fire

- This test method could also be used to evaluate the toxic contribution of the basic fuselage structure, whenever a nonmetallic material is used as the primary component.

## Development of Lab-Scale Toxicity Test For

- resistant materials.

- Decomposition Products During a Postcrash Fire

- Additional full-scale tests required to determine the correlation between
- full- and lab-scale tests.

- Full-scale tests to focus on the amount of toxic gas decomposition
- products entering cabin area from the non-exposed skin side.

## Full-Scale Test Article for Evaluating Non-Metallic Fuselage 

- Full-Scale Test Article for Evaluating Non-Metallic Fuselage

## Full-Scale Test Article for Evaluating Non-Metallic Fuselage 

- Full-Scale Test Article for Evaluating Non-Metallic Fuselage

## Full-Scale Test Article for Evaluating Non-Metallic Fuselage 

- Full-Scale Test Article for Evaluating Non-Metallic Fuselage
# Presentation: 342502

## Implement Positive

**Implement Positive**
**Train Control Systems**

## Safety Improvements Wanted

- Facilitate development and implementation of positive train control systems that include collision avoidance, and
- Require implementation of positive train control on main line tracks, giving priority to high-risk corridors where commuter and intercity passenger railroads operate.  **R-01-6**

## Human Factors Causes

-  Fatigue
-  Sleep-Apnea
-  Medication
-  Reduced visibility
-  Distractions

## Train Accidents

**Train Accidents**

**FRA reported accidents for 2006**
- 195 head-on, rear-end, and side collisions
- 176 or 90% attributed to human factor causes

## FRA Action

- Final rule, effective June 2005
- $4.5 Million grant to Railroad Research Foundation
- Funding NJPTC Program

## Positive Train Control Projects

**Positive Train Control Projects**

**Amtrak **
- 430 miles installed on Northeast Corridor
- 45 miles installed on Michigan Line
**New Jersey Transit**
- 23 miles of 540 miles installed

## Positive Train Control Projects

**Positive Train Control Projects**

**Union Pacific Railroad**
- 193 miles in signaled territory
- 140 miles in dark territory
**Alaska Railroad**
-  611 miles under development

## Positive Train Control Projects

**Positive Train Control Projects**

**BNSF Railway**
- Centralia - Beardstown, IL
- 135 miles
-  Dallas / Fort Worth - Oklahoma City
- 167 miles
**Norfolk Southern Railway **
- Charleston - Columbia, SC
- 114 miles

## Draft Legislation

**U.S. Senate**
**U.S. House of Representatives**

## Implement PositiveTrain Control SystemsProposed Safety Board Action

| Timeliness Classification | YELLOW |
| --- | --- |

**Implement Positive****Train Control Systems****Proposed Safety Board Action**

- Keep issue area on Most Wanted List
- Retain yellow designation:
-    Acceptable response – progressing slowly
# Presentation: 390306

## Laboratory of Respiratory and Special Pathogens

## History of the Laboratories

- Laboratory of Pertussis

- Laboratory of Respiratory and Special Pathogens

- Laboratory of Methods Development and Quality Control

- Product area specialists

- Test development specialists

## Structure of LRSP

## LRSP Responsibilities

- Pertussis vaccines
- Anthrax vaccines
- Plague vaccines

## Pertussis Vaccines	

- Changes in formulation (Tdap, combination vaccines, removal of thimerosal)
- Changes in manufacturing process
- Ongoing monitoring

## Anthrax Vaccines

- Monitoring of licensed vaccine (AVA)
- Assess new generation vaccines
- Use of Animal Rule to demonstrate efficacy

## Plague Vaccines	

- New generation plague vaccines
- Use of Animal Rule to demonstrate efficacy

## Structure of LRSP

**Pertussis**
**Anthrax**

**Pertussis**
**Anthrax**

**Plague**

## Regulatory Workload since 2000

- 365 INDs and amendments reviewed
- 62 BLAs and BLA supplements reviewed
- Taken a lead role within the Center on implementation of the Animal Rule

## Research Program:  Drusilla Burns

*Bordetella pertussis*
- Structure/function studies of PT
- Studies on the mechanism of secretion of PT
*Bacillus anthracis*
- Role of surface proteins in virulence

## Research Program: Tod Merkel

*Bacillus anthracis*
- Identification of important virulence factors
- Development of a mouse aerosol challenge model for inhalation anthrax
*Bordetella pertussis*
- Characterization of critical virulence regulatory pathways

## Research Program: Karen Meysick

*Yersinia *
- Analysis of a novel type III secretion system of *Y. pestis*/*Y. pseudotuberculosis*
- Characterization of the phospholipases of *Y. pestis*/*Y. pseudotuberculosis*
- Development of biological assays to demonstrate correlates of protection for plague vaccines

## Impact of Research on Regulatory Mission

- Design release tests for DTaP vaccines
- Helps manufacturers optimize production of PT
- Conduct proof of concept studies that justify further development of anthrax vaccines and therapeutics
- Identification of new candidate vaccine antigens for plague vaccines
- Development of functional assays that can be used to define correlates of protection for plague vaccines

## Relevance of Research to Regulation

- State-of-the-art knowledge of the areas we regulate
- Expertise to best evaluate tests to assess the safety, purity and potency of vaccines
- Expertise to design and evaluate the efficacy studies for vaccines licensed under the Animal Rule
- Credibility in the field
- Problem solving approach
# Presentation: 449460

##            Comparison between 

-      DAQ / TCL cluster finders...

|  | /t3 (daq) | /t4 (tcl) |
| --- | --- | --- |
| nEvents | 9123 | 9123 |
| nReconstructed | 9011 | 9120 |
| nVtx | 5243 | 5310 |
| nGlobal | 6.28E6 | 6.46E6 |
| nPrimary | 2.54E6 | 2.54E6 |

##  More events with large number of primary tracks

-  More events with large number of primary tracks
-  Fewer events with large number of global tracks

- DAQ cluster finder gets...

## DAQ Cluster finder gets...

-  Smaller RMS distance from global track to hits
-  More short tracks  (more track splitting)
-  Better peak for long tracks

- Why? Consistent with wide distribution of tracking cuts in tcl

## 2-Hit Resolution  (Fabrice Retiere)

## Track Splitting  (Mercedes Noriega)

## Track Merging  (Mercedes Noriega)

## Correlation Functions  (Mercedes Noriega)

- 3D correlation functions:
# Presentation: 761798

## Extending RdbCore at SNS

**Jeff Patton**

**March 9-11, 2005**

**IRMIS Collaboration Meeting**

## Extending the Perl Crawler

- Oracle extensions
- Create sequence objects to generate sequential numeric primary key values.
- Create table triggers to populate primary key sequence number from sequence.
- Modify PVCrawlerDBLayer.pm to make database connection, work with Oracle dates, last_insert_id.
- Modify SNSBootScan.pm to skip specified IOC’s.
- Add sprintf code.
- Create SNS schema data synchronization code.

## If You Have a One-Line Title, Insert a Carriage Return Before the Title

- 1st-order bullet
- 2nd-order bullet
- 3rd-order bullet
- Text is Arial, 22 pt. *Note:* Fonts are already set. We’ve indicated the font type and size for your information. ***Please do not use Helvetica, as this will not display properly on the system used at 701 Scarboro for reviews.***
- Use the master slide to change information on the footer. To change the	master slide, go to the toolbar and select View, Master, Slide Master.
# Presentation: 666600

## EM Energy fractions

- Sergey Burdin
- For
- LAL, Orsay, France

## Cal weight correction for floor 1

**~0.576**

**~0.74**

## Cal weight correction for floor 2

**~1.42**

**~1.04**

## Cal weight correction for floor 3

**~1.01**

## EMF1

**E>25GeV**

**60<inMass<90**

**inMass<60**

## EMF2

**E>25GeV**

**60<inMass<90**

**inMass<60**

## EMF3

**E>25GeV**

**60<inMass<90**

**inMass<60**

## EMF4

**E>25GeV**

**60<inMass<90**

**inMass<60**

## EMF5

**E>25GeV**

**60<inMass<90**

**inMass<60**
# Presentation: 085536

- February 23, 2007

- 2007 Public Health Preparedness Summit

## The Federal Meat Inspection Act;

The Poultry Products Inspection Act; and

The Egg Products Inspection Act.

- The Poultry Products Inspection Act; and
- The Egg Products Inspection Act.

- FSIS performs its food safety, public health and food defense activities under three main acts:

- Acts & Authorizing Statutes

## Whose Pizza Is It?

- All the basic toppings:
- -Dough
- -Tomato Sauce
- -Cheese
- -Shrimp
- -Pepperoni
- -Onions
- -Sausage
- -Mushrooms
- -and Bacon

**Notes:**
First you have the dough
Then you add the cheese
Then the pepperoni
Next, the onions, and then some sausage.
Then peppers, and mushrooms
And of course bacon

## Listeria monocytogenes

- Percentage of Positive Regulatory Samples

## Percentage of Positive Regulatory Samples

*E. coli* O157:H7

## E. coli O157:H7Foodborne Illnesses Have Decreased By 29% Since 1996-98 Baseline

- 1996-2005 FoodNet Foodborne Illness Incidence Data
- (Cases per 100,000 persons)

- Healthy People 2010 Goal

## Listeria monocytogenesFoodborne Illnesses Have Decreased By 32% Since 1996-98 Baseline

- 1996-2005 FoodNet Foodborne Illness Incidence Data
- (Cases per 100,000 persons)

- Healthy People 2010 Goal

## Salmonella

*Salmonella*

## Percentage of Positive Regulatory Samples

- Results of Broiler Carcasses Analyzed for *Salmonella* by Quarter from April 2005 to September 2006

## Enhancing Public Health Protections 
Through Cooperation

- Through Cooperation

- USDA and its sister agencies collaborate together on multi-jurisdictional food safety issues.

## Our Recent Efforts to Enhance 
Public Health Protections Include:

- Public Health Protections Include:

- Laying the foundation for a more robust risk-based inspection system.

## Other Recent Efforts to Enhance Public Health Protections Include:

-      Proposing a new rule to
-      make the lists of retail
-      consignees available on
-      FSIS’ Web site during
-      meat or poultry product
-      recalls.

## Reaching At-Risk Audiences

## The “Be Food Safe” Campaign

## Working in public health is a lot like...

## This is why we must continue to enhance our food safety and public health system.
# Presentation: 200142

## Beams Week in Review

- 5 stores
- Another Record Luminosity -18.31E30
- Machine studies
- Pbars reintroduced to Recycler
- MiniBooNe

- All Experimenters Meeting

## Integrated Luminosity

- All Experimenters Meeting

## Peak Luminosity

- All Experimenters Meeting

## Initial Luminosity

- All Experimenters Meeting

## Initial Luminosity

- Reasons for Recent Improvement
- Tevatron octupole at injection
- MI coalescing/feed forward compensation
- More Pbars used (trying for 90% of stack & larger stack)
- Tighter Accumulator momentum width

- All Experimenters Meeting

## Protons to Collision

- All Experimenters Meeting

## Pbars to Collision

- All Experimenters Meeting

## Tevatron Studies Summary

- New break point installed at 153 GeV and will be helpful in keeping ramp tuned up.
- Octupoles – Now on at injection. This greatly improves lifetime but still being used with experts’ help.
- Synch light calibration – not able to use the technique. Still only have Pbar light.
- Injection matching – normal injection not stable enough to collect experimental data.

- All Experimenters Meeting

## Tevatron Studies Summary

- Tunes before break point addition

- Tunes after break point addition

- All Experimenters Meeting

## Tevatron Studies Summary

- All Experimenters Meeting

## Pbar Studies Summary

- Orbit shift study
- MI to Accumulator lattice matching
- continued refinement, but no clear result
- Accumulator Tunes vs. p/p
- as expected
- Accumulator Beam ‘buzzing’
- The emittance growth rate on the damper from an external noise source is 0.5 - 1.0 (pi/hr)/(W/hz) on a single betatron line
- If an external source is concentrated over only a few betatron lines, we can clearly see the excitation
- If the an external noise source is broadband, it will be difficult to see

- All Experimenters Meeting

## Pbar Studies Summary

- All Experimenters Meeting

## MI Studies Summary

- 53 MHz Beam Loading compensation (continued)
- $2B Emittance in MI
- Transverse (revisited)
- Longitudinal (revisited)
- Tune Measurements using TBT program
- BLT

- All Experimenters Meeting

## MI Studies Summary

- Typical suppression – 28dB

- All Experimenters Meeting

## MI Studies Summary

- Pbar transient beam loading

- All Experimenters Meeting

## Recycler Studies Summary

- Reintroduce Pbars (first since January)
- Improve efficiency
- Tune counter-wave bump
- Adjust RF
- Injection tuning
- ‘Skim’ Pbars before loading Tevatron
- routine
- Stochastic cooling

- All Experimenters Meeting

## Recycler Studies Summary

- All Experimenters Meeting

## Recycler Studies Summary

- ~10 minutes of momentum cooling
- p/p = 8E-04

- All Experimenters Meeting

## Recycler Studies Summary

- All Experimenters Meeting

## MiniBooNe Studies Summary

- Operation in parallel with Stacking
- Beam to dump, continued tuning
- Reduce losses
- Lattice matching

- All Experimenters Meeting

## MiniBooNe Studies Summary

- 15 Hz operation

- All Experimenters Meeting

## MiniBooNe Studies Summary

- 14 Booster ‘turns’

- All Experimenters Meeting
# Presentation: 813724

## CDMP Continuation Proposal

**Project:**
- o To scan SKYLAB analog solar spectroheliograms into digital format.
**Why?**
- o  Old paper and film images are deteriorating.  Studies of anthropogenic and natural forcing on climate variability require contributions from specific solar surface features over many solar cycles.  Skylab data cover 3 periods in 1973 and 1974.  These data will provide solar UV input for NRL models for times when little or no solar UV data exist, except for proxy estimates.
**Results:**
- o  Digital images will reside on the NGDC and the NRL web site.
-   Spectra scanned during FY06 CDMP:  http:/ares.nrl.navy.mil/~reduce

**CDMP Continuation Proposal**

- CDMP SolarNRL 2006

**Notes:**
Sun Rallies Its Forces  The Sun is once again producing X level solar flares, with an X4.8 flare on July 23 from NOAA Active Region 10,039 and an X3 event associated with a halo coronal mass ejection (CME) on July 15.from NOAA Active Region 10,030.  There were reports of "substantial" impacts for aircraft controllers communicating with various aircraft during these events, though much of this information is internally protected by private companies and also protected by Homeland Security risks in DOD operations.  The low latitude geomagnetic field has not been significantly disturbed, because the Earth’s magnetic field effectively deflected the solar explosions.  As we get closer to the September equinox period, the chances of a good geo-effective connection improve considerably, making us more vulnerable to local environmental impacts. 

## CDMP ProposedProject

- CDMP ProposedProject

- Scan solar spectra images and supporting documents
- Film strips 254 mm x 35 mm mounted on glass plates 340 mm x 50 mm – about 1100 plates
- 14 data books with ~1750 pages – save in PDF
- Use OCR or data entry to convert metadata (PDF files or data books) to electronic format.  Books from both FY06 and FY07 (~ 15 books).

- CDMP Solar NRL 2006

- Example of film mounted in plates.

- Data book pages

## Proposed Tasks

- NRL prepares plates and data books for contractor
- Contractor scans ~1100 plates to be save in tiff format at 24 bit (three color) resolution (~4096 bpi)
- Contractor enters metadata into electronic format using PDF files or original books via OCR or data entry.

-   NRL reviews and quality controls images and PDF files.
-   NRL provides UMAX PL3000 flatbed scanner
-   Images available online at NOAA and NRL web sites
-        (preliminary web site: http:/ares.nrl.navy.mil/~reduce)
- – J. Morrill, NRL and H. Coffey, NGDC

- CDMP Solar NRL 2006
# Presentation: 712195

## Suspicious Activity Report Filing Trend for the State of West Virginia                                                                                       For the Period April 1, 1996 through December 31, 2007

**Suspicious Activity Report Filing Trend for the State of West Virginia                                                                                       For the Period April 1, 1996 through December 31, 2007**

***Total SARs: 6,352***

## Characterizations of Suspicious Activity for the State of West Virginia

- Note:  The pie chart represents the top nine characterizations plus additional characterizations in total.
-            An individual SAR may cite more than one characterization.  Hence, the number of characterizations detailed here significantly exceeds the total number of SARs.

**Characterizations of Suspicious Activity for the State of West Virginia**
**For the Period April 1, 1996 through December 31, 2007**

## West Virginia Mortgage Loan Fraud SAR Filing Trend For the Period April 1, 1996 through December 31, 2007

***Total SARs: 272***

- Note:  Suspicious Activity Report statistical data is continuously updated as additional reports are filed and processed.  For this reason, there may be minor discrepancies between the statistical figures contained in this report and those in previous FinCEN reports.  Annual numbers for this exhibit are calculated by ***Subject Address*** and not filer address; therefore, the annual totals appearing in the above graph do not match those in Section 1, Exhibit 8 (Characterization of Suspicious Activity by State & Territory by Year).

## Suspicious Activity Report Geographic Pattern for the State of West Virginia

**For the Period January 1, 2006 through December 31, 2006**

**Note: Statistics based on Filer Branch Address**

- Charles Town

## Suspicious Activity Report Geographic Pattern for the State of West Virginia

**For the Period January 1, 2007 through December 31, 2007**

**Note: Statistics based on Filer Branch Address**

- Charles Town
# Presentation: 081201

## Presented by:Mike Moran, ManagerFacility Energy Program OfficeFacilities & Operations DirectoratePNNL-SA-49664

**Green Power Purchasing at PNNL**

## PNNL’s Diverse Campus

## Slide 3

## Slide 4

## Slide 5

## Slide 6

## Began in 2002 by Partnering with Hanford Site

- We had a vote with the other Site stakeholders
- 13% of Hanford Site consumption
- Bonneville Power Administration provides electricity to the Government portion of our campus
- $0.003/kWh
- Power generation source is small hydro from Idaho
- Provided 3% of PNNL power as Green Power

## We Expanded Our Portfolio in 2003

- Stateline Wind Farm only 30 miles away
- Green Power was not offered through the City of Richland
- Partnered with the City to purchase a block of wind power (City/BPA contract – PNNL utility bill)
- Our partnership started the program to City residents
- $0.011/kWh
- Combination of wind and small hydro provided 13.5% Green Power to PNNL

## We Diversified Even More in 2004

- Marine Research Operations (MRO) in Sequim, Wahington
- Power provided by Clallum County PUD
- Green Power was offered but no one was buying
- $0.006/kWh for landfill gas generated power from neighboring Klickitat Co.
- Separate charge on the statement
- This combined with the others got us to 14.7% green and the MRO was 100% green

## We Changed Billing Strategy in 2005

- Moved from lump-sum payment for some of the power to include it in the purchase price as the meter turns
- This makes it easier for billing and payments and is easier to track percentages of power

## Slide 11

## How can we afford the premium on top of the normal price?

- We do not ask for additional money; we self generate it through an aggressive energy conservation program
- Electricity reduction contest
- Wattstopper® plug strips/computer monitor settings
- Energy audits of selected facilities
- ENERGY STAR® Buildings
- Using technology
- Alternative financing

## How can you do this?

- Know your provider and your consumption
- How much is the Green Power?
- How much do you want to purchase?
- How are you going to pay for it?
- Research existing programs that are available to you through your provider
- If none exist, you can be the catalyst to make it happen!

## Questions/Comments?

- _http://www.pnl.gov/conserve-energy/index.htm_

**Questions/Comments?**

**CONSERVING **
**ENERGY**
**AT PNNL**
# Presentation: 749357

## Data Fusion: MODIS Terra & Aqua Aerosol Optical Thickness

*Viktor Zubko, Gregory Leptoukh and Arun Gopalan, GES DISC Code 610.2*

**Data Fusion** (DF) is a method of *combining* near-coincident (in time and space) satellite data to produce *complete* global or regional maps. This is important because satellite data contain gaps arising from Sun glint, clouds, interorbital areas, or retrieval algorithm failures.
- DF usually includes data *merging* and *interpolation* steps.
- The *goal* of the work is to find a *fast* and *accurate* DF method for implementation into Giovanni.
- We investigated various methods and limitations of data merging with and without interpolation using MODIS Terra and Aqua Daily Level 3 Aerosol Optical Thickness (AOT) data as a prototype.
- To assess the merger accuracy, we introduced a *merging confidence function*, which is the percentage of the merged AOT pixels as a function of the relative deviation of the merged AOT from the initial Terra and Aqua AOTs.
- We worked with eight different combinations of merging and interpolation. The best method is to first merge the Terra and Aqua AOTs, and then to fill in the remaining gaps by interpolation.

- Initial AOT

- Merged AOT

- Terra & Aqua AOT

- Interpolated AOT

**Data**:
- MODIS Terra AOT (T)
- MODIS Aqua AOT (A)
**Combining Options**:
- Merging (M)
- Interpolation (I)
- Simultaneous M and I (MI)
**Used Combinations:**
-   **i[m(t,a)]:** M(T, A)→I
-   m[i(t),i(a)]: I(T), I(A)→M
-   mi(t,a): MI(T,A)
-   m[mi(t),mi(a)]: MI(T), MI(A)→M
-   i(t): I(T)
-   i(a): I(A)
-   mi(t): MI(T)
-   mi(a): MI(A)

- Continuous Original scene

- Realistic gaps
# Presentation: 914770

## Polycystic Ovary Syndromeand Insulin Resistance 

- Francis Byrn, M.D.

## Objectives

- Review clinical spectrum of PCOS
- Discuss evolving understanding of role of insulin resistance on the variable presentations of PCOS
- Appreciate both the reproductive and metabolic implications of insulin resistance

## Amenorrhea Associated With Bilateral Polycystic Ovaries

- Enlarged polycystic ovaries
- Hirsutism
- Obesity
- Anovulation (Infertility)
- Stein IF, Leventhal ML
- Am J Obstet Gynecol 1935

## 1980s – Association with PCOS

- HAIR-AN  Syndrome
- 	hyperandrogenism
- 	insulin resistance
- 	acanthosis nigricans

## “Old” vs “New” PCOS

- _Variable phenotype; Account for_:
- Perimenarchal onset
- Variable degrees of hirsutism
- Variable association with obesity
- Variable association with muscle mass
- Variable association with LH:FSH ratios

## NICHD Conference 1990

_**Definite or Probable Diagnostic Criteria**_
- Hyperandrogenemia		64 %
- Exclusion of other origins	60 %
- Exclusion of CAH			59 %
- Menstrual dysfunction		52 %
- Clinical hyperandrogenism	48 %

## NICHD Conference 1990

_**Possible Diagnostic Criteria**_
- Insulin resistance				69%
- Perimenarchal onset				62 %
- Elevated LH : FSH				55 %
- PCO by ultrasound				52 %

## 1990 NICHD Conference on PCOS Consensus Definition

- Ovulatory dysfunction
- Evidence of hyperandrogenism
- Clinical
- Biochemical
- Exclusion of other diseases

## Pathophysiology of Polycystic Ovary Syndrome

- LH Hypothesis
- Insulin Hypothesis
- Ovarian Hypothesis

## PCOS and Insulin Resistance

- Emerging interest in two separate insulin-resistant syndromes:
- Metabolic Syndrome X
- Polycystic Ovary Syndrome
# Presentation: 214854

## Proprietary Name Testing Using “Prescription Analysis Studies”

- Thomas H. Hassall, MS
- Director, Global Regulatory Policy
- Merck Research Laboratories

## FDA’s Trademark Assessment Process

**“****Expert Panel”** - DMETS staff panel identifies a pool of proprietary names with potential for confusion
**“****Prescription Analysis Studies”** - to “determine the degree of confusion of the proposed name with other names due to handwriting or verbal pronunciation”1
**“****Safety Evaluator Risk Assessment”** - Considers similarities vs mitigating factors (population, dose, dosage form, regimen, route, consequence of error, other).  This is a “judgment call.”
- 1.  Quote from text of DMETS review

## Summary of 17 FDA Prescription Analysis Studies

- Initial Sample = 22 Reviews
- 5 Did not perform RX Analysis
- --Remaining 17--
- 2002 (2); 2001 (8); 2000 (6); 1999 (1)
- 9 different reviewers
- Average time to completion = 60 days (range = 16 - 135 days)

## Summary of 17 Prescription Analysis Studies

- Sample Size/Response(%) and Outcome
- Outpatient Written	33/60%	75% correct*
- Inpatient Written	33/60%	56% correct*
- Telephone		33/47%	23% correct*
- *most incorrect responses were phonetic misspelling of the name
- In 13 of 17 studies (76%), no mix-up with an existing name occurred
- In 4 studies, actual mis-identification occurred (2 acceptable; 2 unacceptable)

## Reviewer Conclusions vs % Correct/Incorrect Responses

## My Conclusions

**Prescription Analysis Studies...**
- Do not _*test*_ names for the risk of medication error;
- An incorrect response involving an existing name is not significant by itself;
- Lack of an incorrect response involving an existing name is not significant by itself;
- Do not “determine _*the degree of confusion*_ of the proposed name with other names due to hand-writing or verbal pronunciation;”
- Do not produce _*reliably reproducible results.*_

## My Conclusions

**Prescription Analysis Studies...**
- Are _*useful screening tools*_ that may enrich the pool of potentially confusing candidate names initially generated by the expert panel that will undergo the Safety Evaluator Risk Assessment;
- Do not identify potential errors _*with a higher or lower risk for occurrence*_ compared with other names in the pool identified by the expert panel;

## My Conclusions

- Recommendation #238 - HHS Advisory Committee on Regulatory Reform calls for -
- FDA review of _*Manufacturer generated data*_ from
_*Protocols*_ designed to _*evaluate their products’ names *_for possible look-alike and sound-alike names;
- FDA’s role should be to confirm that “GNP’s” (good naming practices) have been followed.

## My Conclusions

- The usefulness of any _*test*_ or _*study*_ that is purported to _*actually assess the risk*_ of name confusion that may contribute to medication errors must be validated before it can be recommended for regulatory purposes.
# Presentation: 302223

## Joseph Epperson, Materials Group Chairman

**Metallurgical Findings**

## Recovered Jackscrew Assembly

**Recovered Jackscrew Assembly**

- Screw attached to horizontal stabilizer
- Separated from acme nut
- Nut thread remnants on screw

## Closeup of Thread Remnants

## Jackscrew with Lower Stop

- No grease in working area of screw
- Sandy grease on lower end of screw
- Oil sheen on upper end of screw
- Grease on lower stop with nut contact marks
- Fractured torque tube

## Lower Mechanical Stop

- Lower stop recovered separately
- Grease on stop
- Marks on upper surface from contact with acme nut after nut thread separation
- Created offset loading of the torque tube
- Spline damage from rotation of screw

## As Recovered Acme Nut

- Threads completely stripped
- No grease on interior or adjacent surfaces
- Grease fitting passage blocked
- Red and green grease on surrounding structure

## Used Nut with Worn Threads

**Accident Nut with Stripped Threads**

## Torque Tube Fracture

- Fractured in threads at lower end of the acme screw
- Low cycle fatigue cracking
- Similar fractures could be produced by high stress in a few cycles

## Two & Three Dimensional Finite Element Analyses to Determine Thread Loading and Contact Pressure Distributions

## Conclusions from Finite Element Analyses

- Approximately 90% of screw load reacted in four threads
- Loads shift as thread wear progresses
- The maximum value of the contact pressure does not change as wear progresses - 3,000 to 4,000 average over contact area
- At large levels of thread wear (> 0.080) under normal operating loads, large bending deformations develop which are consistent with the thread remnant wear shape

## Thread Remnant

- SHEAR FRACTURE
- At major diameter
- Less than 10% of the cross section remained
- WEAR
- Multiple bevel/stages
- Unique wear / deformation shape

## Thread Deformation Sequence

## Summary of Findings

- Material and structural conditions did not contribute to the acme nut wear
- No grease in working area of the screw
- Grease not removed by ocean impact, exposure, or recovery
- Jackscrew grease not contaminated
- The wear is caused by sliding contact and is consistent with an unlubricated condition
- Torque tube fractured by low cycle fatigue

## Metallurgical Findings

## Additional Photographs

- Lower stop in contact with the acme nut

## Additional Photographs 

- Interior of lower stop

## Remnant Positions vs Trim Positions
# Presentation: 700450

## New Climate Observations Introduced

- FY2004 Target: 275 new ARGO floats deployed;
- May 2004 Actual:  340 ARGO floats, 518 total ocean observing platforms

- FY04 Target = 275

## Reduce the Error in Global Measurements of Sea Surface Temperature

- Long-term Target: Error of 0.2 °C by 2008
- Actual:

- Expanding the in situ network will minimize the satellite bias error, enabling more accurate, enabling more accurate global sea surface temperature from a combination of satellite and in situ measurements

- Note: this measure is proposed as a new GPRA for FY2006; it is already reported on quarterly

- Satellite bias error: the systematic difference between satellite-derived vs. in situ measurements of sea surface temperature