# Presentation: 363804

## Jan 2006 CDRP Progress Report Laredo Grant 

**Jan 2006 CDRP Progress Report ****Laredo Grant **

- Evaluating Cancer Disparities Among Hispanic Communities

**Bobby Bains MD,  PI**

## Research Organizational Chart

**Laredo Cancer Disparities Grant**
**Y Bains, MD**
**Principal Investigator**

**GI**

**Mets**

**Breast**

**Chemo**

**Public Health /**
**Screening**

**Communication Effectiveness**

**Community Outreach**

- Anuja Jhingran
- MDA

- Charles Thomas
- UTHSCSA

- Gary Unzeitig
- Breast Surgeon

- Eduardo Miranda
- Med. Oncology

- Maria Fernandez
- UT School of Public Health

- Melinda Villagran
- UTSA
- Dept of Communication

- Oscar Munoz
- Texas A&M Colonias Program

**LUNG**

**GYN**

- Charles Thomas
- UTHSCSA

- Y Bains MD
- LMC, UTHSCSA

- Ian Thompson
- UTHSCSA

**GU**

**CDRP**
**TRIALS**

- Daniel G. Petereit
- Rapid City Regional Hospital

- Singing River Hospital

- HDR Prostate Study

- Amifostine Study

**N**
**A**
**V**
**I**
**G**
**A**
**T**
**I**
**O**
**N**

- Dr. Tony Eng
- UTHSCSA

##  CDRP Clinical Trials

- 8 Clinical Trials to date
- 5 Open and Active
- 1 Study NOT approved by local IRB
- 2 Closed Studies
- 13 total patients accrued

## Open and Active Clinical Studies

**NCIC – MA20** A Phase III Study of Regional Therapy in Early Breast Cancer   --  **4 patients enrolled**
- A Pilot Study of Hypo-Fractionated External Beam Radiation and HDR Brachytherapy for Advanced Prostate Cancer.             ( **CDRP Trial,** **Dan Petereit – PI** )  --  *No patients.  Urologists not on board*
- Pilot Trial of Enbrel in Patients with Cancer-associated Fatigue and Cachexia Receiving External Beam Radiotherapy.  (**Inhouse Trial, C Thomas PI**)  --  **1 patient enrolled**
- Open-Label, Multicenter Prospective Trial Evaluating the Reduction of Treatment Breaks with Ethyol® in Patients with Measurable, Unresectable NSCLC.  (**R. Wynn PI**)  -- **2 patients enrolled**
- A Prospective, Randomized Pilot Study of Melatonin vs. Placebo to Reduce Skin Toxicity and Treatment Breaks in Breast Cancer Patients Treated with Conservative Surgery and Radiation Therapy. (**Inhouse Trial, Y. Bains PI**).  Awaiting DSMB final approval/Web registration setup

## Closed Clinical Studies

**RTOG 0122** A Double-Blind Study of Nutritional Intervention for the Treatment of Cancer Cachexia Using Juven Nutritional Supplement. (**6 pts enrolled**) **[ *****Trial closed / completed accrual***** ]**
**RTOG BR 0118 **A Phase III Study of Conventional Radiation Therapy Plus Thalidomide (NSC# 66847) Versus Conventional Radiation Therapy for Multiple Brain Metastases.  **[ *****protocol closed by RTOG soon after local IRB approval obtained***** ]**

## Study NOT approved by LOCAL IRB

**NSABP B-39** / **RTOG 0413**: A Randomized Phase III Study of Conventional Whole Breast Irradiation (WBI) Versus Partial Breast Irradiation (PBI) for Women with Stage 0, I, and II Breast Cancer

- IRB **Recommendation:**   Surgeon, Radiation Oncologist, Physicist to perform 5 placements of Mammosite Catheter and Treatment OFF protocol to demonstrate competence.

- Status Update:  2 placements of Mammosite completed.  Confounding factor: BC/BS of Texas NOT covering cost of surgical placement/mammosite balloon.

## Navigator Studies

- 5 Navigator Studies to date
- 3 studies completed
- 1 Closed accrual; continue to follow up
- 1 open and active
- 877 Total subjects in studies
- 600 = Approximate Navigation Visits to date
- 168 = Total Navigation Visits in 2005

## Navigator Studies

- San Antonio Center of Biomarkers of Risk for Prostate Cancer (SABOR). (300 pts.)  [closed to new accruals, follow up on previous subjects only]
- FREE MAMMOGRAM PROGRAM IN COLONIAS: A Communication Effectiveness Study. Oct-May 2004 (36 subjects)
- Evaluating Colorectal Cancer Screening Among Low Income Hispanics (Focus Groups members 32; 200 surveys)
- CANCER SURVEY IN COLONIAS: Awareness, Perception, and Knowledge of Cancer Among Hispanics in Colonias.  June-July 2005 (300 subjects)
- STAR – Study of Tamoxifen and Raloxifene for the prevention of breast cancer.  NSABP Protocol P-02  (11 patients accrued)

## Telesynergy Use

- 4370 minutes of use from Jan 2005-Dec 2006
- Staff Training
- Meetings
- UTHSCSA Radiation Oncology Weekly Lecture Series
- UTHSCSA / CTRC  Gynecology Oncology Weekly Tumor Boards

## Slide 10

## PUBLICATION

- Fernandez ME, Torres I, Vernon S, Byrd T, Hinojosa-Lindsey M, Wippold R, Bains Y.  _Colorectal cancer screening among Latinos from U.S. cities along the Texas-Mexico border:  a qualitative study._  Prev Chronic Dis [serial online] 2005 Apr.

## Abstracts (posters) presented at ASTRO ‘05

- _Barriers Faced by Mexican American Patients During Radiation Therapy:  Preliminary Results of the Laredo Navigator Project of the NCI U56 Cancer Disparities Research Partnership Program.  _Bains, Yadvindera; Guajardo, Jessica O.; Cerda, Melissa; Thomas, Charles R.
- _Preliminary Investigation of Preferred Mediated and Interpersonal Sources of Health Information Among Low-income Hispanic Women Receiving Mammograms:  The Laredo NCI U56 Health Care Disparities Navigator Program._ Villagran, Melinda; Bains, Yadvindera S., Guajardo, Jessica; Munoz, Oscar; Thomas, Charles.

## THANK YOU !