BEE-spoke-data/govdocs1-by-extension huggingface dataset:
# Presentation: 737231

## FDA’s 510(k) Third-Party Review Program

**Blood Products Advisory**
**Committee Meeting**
**Gaithersburg, MD**
**September 15, 2000**
**Eric J. Rechen**
**Office of Device Evaluation**
**CDRH, FDA**

## Purpose of Program

**Provide an alternative 510(k) review process that can yield more rapid marketing clearance decisions**
**Enable FDA to target its resources at higher-risk devices**

## Origin

**1996 -****	****FDA began 2-year pilot**
**1997 -****	****FDAMA enacted; established**
**	****	****	****§523:  “Accredited Persons”**
**1998 -****	****AP program implemented**
***	******	******http://www.fda.gov/cdrh/thirdparty***

## Main Features

**FDA accredits third parties (APs)**
**Mfr. may elect to use AP or FDA**
**If AP route is chosen:**
**Mfr. contracts for review, sends 510(k) to AP**
**AP reviews 510(k), makes recommendation to FDA**
**FDA issues final decision (30 days)**

## Accredited Organizations

**British Standards Institution  (United Kingdom)**
**California Department of Health Services**
**Center for Measurement Standards, ITRI  (Taiwan)**
**Cheiroon BV  (Netherlands)**
**CITECH**
**Entela, Inc.**
**Intertek Testing Services**
**NIOM Scand. Inst. of Dental Materials  (Norway)**
**N.V. Kema  (Netherlands)**
**TUV Product Service**
**TUV Rheinland of North America, Inc.**
**Underwriters Laboratories, Inc.**

## Devices - Statutory Criteria

**Accredited Persons may not review:**
**Class III devices**
**Class II devices that:**
**are permanently implantable**
**are life sustaining/supporting, or**
**require clinical data in 510(k)s**

## List of Eligible Devices

**Current list includes 211 devices**
**  ****57 Class I devices**
**154 Class II devices**
**More than 1,600 eligible 510(k)s/year**
**“****Expansion pilot” recently proposed**
**Devices reviewed by CBER/CDER not included at this time**

## Program Experience

**Industry participation low, but growing**
**Good quality reviews**
**More rapid 510(k) clearance**
# Presentation: 867156

## Review and Wrap-Up

- 	AeroDyn Overhaul Kick-Off Meeting
- National Wind Technology Center (NWTC)
- Boulder, CO (USA)
- February 13-14, 2008

**Review and Wrap-Up**

## Plan Forward

- Release latest versions of WT_Perf, FAST, and A2AD before starting redevelopment of AeroDyn
- Anticipated first release of AeroDyn v13.00 in FY2009:
- The first release will contain existing and modified features, but not all proposed features:
- New features will be prioritized
- Old AeroDyn interfaces will not be supported
- HydroDyn (for offshore hydrodynamics analysis) will also be released as a stand-alone library, with a similar interface to AeroDyn:
- Currently HydroDyn is built into FAST and A2AD
- Anticipated first release to be with AeroDyn v13.00
- Our next big upgrade to FAST (with coupled modes) will be work started after the first release of AeroDyn

## Plan Forward (cont)

- M. Buhl will be in charge of coding AeroDyn I/O & interface routines
- J. Jonkman will be in charge of coding AeroDyn’s internal modules (theory), developing HydroDyn, & modifications to FAST & A2AD
- P. Moriarty will develop stand-alone aeroacoustics DLL
- P. Moriarty and G. Bir will provide theoretical support
- When questions on how to proceed arise, we will post questions on the web-based NWTC forum or mailing list
- Everyone can provide feedback through the forum or mailing list

## Review of Proposed Changes

- See meeting notes
- How should we prioritize the proposed changes?

## Discussion Forum

- Existing approach:
- NREL has an existing discussion forum
- http://wind.nrel.gov/forum/wind/
- Used for
- Exchanging of ideas
- Asking questions
- Providing feedback
- NREL has an existing mailing list (MajorDomo)
- Existing problem:
- Forum not getting much use now
- Lack of regular postings means users have quit checking
- Mailing list does not have an archive capability
- When people reply to the mailing, they reply to the originator instead of the mailing list

## Discussion Forum (cont)

- Proposed modifications:
- Add AeroDyn-development _[forum](http://wind.nrel.gov/forum/wind/viewforum.php?f=19)_
- Discussion points:
- Should we switch to new mailing list software with archive capabilities instead of using forum?
- Set aside a special mailing list for AeroDyn development?
# Presentation: 709336

## MEAN BIAS CORRECTION ON NCEP SPETRAL MODEL FOR SEASONAL CLIMATE SIMULATIONHann-Ming Henry Juang and Jun WangEnvironmental Modeling Center, NCEP, Washington DC

**Motivation**
- It is found that there are some systematic differences between the RSM forecasted large scale fields and the global background fields. Since RSM uses the perturbation as the forecast variables, is this difference related to the mean perturbation?  Can this systematic difference be corrected by getting rid of the mean perturbation?

**System Difference between GSM and RSM**

**Model setup and experiment design**
**Model**: Nested RSM model
-   gsm: GFS2003, T62L28
-   rsm: rsm2004 50 km, 28 levels
-   domain: US continental (lon:-130 - -70, lat:22-50)
**Experimen**t:
-   Control: RSM seasonal forecast run without mean perturbation correction
-   RSM_w0: RSM run with mean perturbation correction
-     Case: Sept 1982, Nov 2002, May 2004

**Results**

- Summer case: 200405

- Mean perturbation has more impact on summer case than on winter case, why?

- The effect of mean perturbation correction

**Summary**
- The systematic difference between GSM and RSM is related to the mean perturbation in RSM model. After mean perturbation correction, the systematic error can be reduced. The correction has more impact on summer season than on winter season.

- Winter case: 200211

- BLK: GSM GRN:RSM BLU:RSM_w0
# Presentation: 840445

## The Complexities of Doing Business with ChinaChina Business ConferenceMay 23, 2006

- Peter Dempsey
- Manager, Business Advisory Services
- The US-China Business Council

## The US-China Business Council

*The US-China Business Council is the principal organization of US companies engaged in trade and investment in the People’s Republic of China. Founded in 1973, the Council serves more than 250 corporate members through its offices in Washington, DC, Beijing, and Shanghai.*
*See: ***www.uschina.org**

- Business Advisory Services (BAS)
- Government Advocacy
- Publications    -*China Business Review**     **-**China Market Intelligence*
- Programs

## 
American Companies Building
Success in China - 
Significant Issues Remain
Results of the 2005 USCBC Member Survey

**American Companies Building**
**Success in China - **
**Significant Issues Remain**
- Results of the 2005 USCBC Member Survey

## US Companies Prioritize

## US Companies Profit

## Top Issues

- Intellectual Property Rights (IPR) Protection
- Distribution Rights
- Transparency
- Human Resources
- Standards

## IPR

- Legal environment improving – very slowly
- Highly inconsistent enforcement
- Disconnect between concerned senior PRC leaders and non-compliant local officials
- Counterfeit exports are a growing & serious concern
- R&D efforts affected by negative IPR environment
- Product liability issues – Ex: fake brakes, baby food

## Distribution

- The ability to sell domestically what you have sourced locally or already imported
- DOES NOT include right to import
- Highly important WTO commitment
- Cumbersome implementation process that USCBC actively pushed PRC to get right

## Transparency

- How well do you know
- what is going on?
- Regulations
- Market data
- Approval processes
- Relevant authorities

## Human Resources

- Increasingly difficult to recruit and retain managerial personnel
- Costs are rising steadily – global levels for senior local staff
- Signs of over-localization and reverse localization
- Workers – fewer problems if salary/environment/benefits competitive

## Standards

- Standards setting process is opaque
- Comment periods are short or non-existent
- Multiple regulatory bodies
- Testing difficulties

## What Can You Do?

- Define priorities – set measurable goals
- Clear strategy (IPR, HR, Standards, etc. before it becomes problem)
- Best investment vehicle option
- 6 Ds
- Understand role of central & local govt.

## Food for Thought:Cities with 1 million + population

- Thank You!

## US-China Business Council Peter DempseyManager, Business Advisory Services1818 N St NW, Suite 200

- Washington, DC 20036
- Tel: 202-429-0340Fax: 202-775-2476E-mail: pdempsey@uschina.org

**Shanghai Office**1701 Beijing West Road, Room 1301Shanghai 200040Tel: 86-21-6288-3840Fax: 86-21-6288-3841Email: info@uschina.org.cn

**Beijing Office**CITIC Building, Suite 10-01
- 19 Jianguomenwai Ave.Beijing 100004Tel: 86-10-6592-0727Fax: 86-10-6512-5854 Email: info@uschina.org.cn
# Presentation: 671420

## SPACECRAFT ACCIDENTS: EXAMINING THE PAST, IMPROVING THE FUTURE Apollo 13

- Bryan Palaszewski
- working with the
- Digital Learning Network
- NASA Glenn Research Center

## Apollo 13 (1/2)

- Launched: April 11, 1970
- Mission: Explore the lunar surface with 2 persons, Fra Mauro Region, the Moon
- On April 13 the oxygen tank ruptured, causing loss of power and oxygen for the crew.

## Apollo 13 (2/2)

- Crew transferred to Lunar Module and used its power and oxygen for life support.
- Original mission was aborted.
- Landed safely on Earth: April 17, 1970

## Slide 4

## Apollo 13 Results (1/2)

- After the flight, an investigation committee was formed to assess the cause(s).
- The oxygen (O2) tank rupture was causing by damaged wiring in the tank.
- The damage was caused when improper procedures were used for emptying the tank during ground testing.

## Apollo 13 Results (2/2)

- Failure was re-created in ground testing.
- The O2 tank failure damaged the fuel cells that generate power for the astronauts.
- In future vehicles, an additional O2 tank was added for safety.

## Slide 7

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# Presentation: 223387

## PRZM Enlightenment

- Dirk F. Young
- U.S. EPA
- Feb 2007

## Introduction

- The following are some examples of current issues with PRZM.
- Discussions between EFED and ORD in January 2007 have taken place on these and other issues regarding PRZM
- Many of these issues were uncovered during the NAFTA GW evaluation, the carbamate cumulative, and during the development of parallel PRZM.

## Runoff Extraction(Distributed Flow Conceptualization)

## Extraction Notes

- Unknown which is extraction method is the intentional one
- Current documentation is unclear on how extraction was derived
- Request in to ORD to locate calibration methodology and data

## Erosion Issues

- MUSS selected as EFED PRZM standard: Jimmy William’s comments
- “Time of Concentration” calculation in PRZM code uses runoff instead of precipitation (oddly, documentation is correct)

## Sorbed Contaminant Erosion

- Contaminant transported by erosion is proportional to the vertical spatial increment selected
- Erosion solids not at equilibrium with runoff solution
- Kd enhancement questions

## Contaminant Transport Via Erosion(Vertical Spatial Dependence)

- Smaller Increments-Less Transport

- Larger Increments-More Transport

## Erosion Equilibrium Issues

- Erosion With
- Zero Contaminant
- (also Kd issue)

- Runoff With
- Contaminant

## ORD requests

- Request to ORD for independence of erosion zone from size of 1st increment
- Request to ORD to examine Kd enhancement as it relates to organic solutes
- Request for equilibrium assurance

## Irrigation Independence

- Current PRZM: Irrigation
- Demand determined by
- Root depth.

- Desired to have
- an independent
- Irrigation depth

- Request made to ORD

## Other Bugs and Issues

- RODPTH variable acts erratically when discretization changes occur around 10 cm: *Solution use consistent discretiztion well below 10cm.*
- NCOM1 changes during simulation. Affects evaporation. Cause and fix unknown.
- Depth of evaporation is overestimated by one node.  *Solution: do not radically increase discretization around the max evaporation depth.*
- Crop stages are implemented a day early.
- Foliar Washoff is NOT distributed in a linearly decreasing manner, as the text states.  Rather, It is UNIFORMLY distributed to 2 cm.
- Incorrect units in the Hamon formula for PET.  Do not use.
- Common Misconception: moisture is extracted “... from each layer until wilting point is reached in each layer ...”.  Moisture extraction is not sequential rather it is extracted simultaneously from each layer.
# Presentation: 381956

## Computational Nanochemistry

***optical characterization by emission pattern imaging*****:** MEH-PPV nanoparticles act like single (z-oriented) atoms! - signature of quantum dot behavior

***synthetic methodology*****:** nanoparticle generation of semiconducting polymers (MEH-PPV) from microdroplets of dilute of solution - 3-D confinement should produce rod-shaped nanocrystalline particles

**Goal**: To make polymer analogues of inorganic semiconductor quantum dots *without* specialized synthetic chemistry

**Issues**:
-  Control of chain organization, alignment
-  Optical signature of ‘artificial atom’ behavior in polymer nanoparticles?

**Questions**:
-  Choice/range of materials?
-   How might polymer q-dots differ from inorganic dots (morphology, orientation, etc.)?

**Applications**:
-  Nanophotonics - tunable optical interface to nanoworld
-  Molecular wires for nanoscale computing
-  Bioconjugate (fluorescent marker) applications

***Computational Nanochemistry***

***Typical conformation of C20H42 inside a (7,7) carbon nanotube and in vacuum***

- Temperature dependence of the kinetics for polymeriza-tion of ethylene in various geometries.  The kinetics are faster by more than an order of magnitude in the bulk.

- Weight-averaged molecular weight for the polymerization of polyethylene in various geometries at 3200K.  The reaction proceeds much more slowly in the nanotube.

***For both the pyrolysis and polymerization reactions, the reaction kinetics are inhibited in the interior of the carbon nanotube***
***This effect is much larger in the polymerization reaction***

***Polymer Quantum Dots***

***Polymer Normal Modes***

- Is it possible to simulate properties of experimentally designed complex polymer structures?

- Polymer structures involve tens of thousands of monomer units.  Dynamic studies involve coupled motions of thousands of bodies.

- Normal modes involve generation and processing of extremely large, sparse matrices.

- Applications include modeling properties of designed polymer structures

- High impact work, recently featured in such places as *The Journal of Physical Chemistry*

**Funding Sources**

- Schematic of the contrasting intergranular film segregation behavior of Lu and La in SiO2-rich glassy triple pockets, according to proposed theoretical model.

- Strong Y-N bonding is consistent with an observed increase in fracture toughness

***Ceramic Properties***

- Correlation between measured aspect ratios and the energy****calculated in local density formalism.
# Presentation: 062445

## <footer>

- <date/time>

**YES**

**NO**

**Unacceptable **
*C1U, C2U, C3U, or C4U*
*Negative impact on score*
*Describe inclusion plan, rationale for any age range exclusions, suitability of team and facilities for dealing with children, plans for meaningful analysis of differential effect. *
*State why this is scientifically unacceptable.*

**Acceptable **
*C1A, C2A, C3A, or C4A*
*Describe: inclusion plan, rationale for any age range exclusions, suitability of team and facilities for dealing with children, plans for meaningful analysis of differential effect. *
*State why this is scientifically acceptable.*

**Decision Tree for Inclusion of Children in Human Subjects Research**

**YES**

**NO**

- _[Human Subjects](http://grants.nih.gov/grants/peer/tree_glossary.pdf)_** involved ****(even if exempted under 45 CFR 46)?**

*Inclusion policy does not apply*

**What is the representation of children and adults? Is representation of children acceptable?**
- 1. Both children and adults are included in scientifically appropriate numbers and
- 	with appropriate age ranges for children?  ***(Code C1: both adults and children)**** *
- 2. Only children are included? ***(Code C2: children only)***
- 3. All or some age ranges of children are excluded because one of the following exceptions applies?
- The research topic is irrelevant to children
- Laws or regulations bar inclusion of children in the research
- The data already exists or is being obtained for children (must document); duplicative studies are unnecessary
- A separate, age-specific study in children is preferable (e.g., conditions are rare in children vs. adults; most eligible subjects already enrolled in nationwide study; study design issues preclude applying hypotheses/interventions to both groups in parallel fashion)
- Existing data in adults is insufficient to judge risks in children
- Proposal is to obtain follow-up data on a prior adult study which enrolled no children
- Other special cases acceptable to the review group and Institute Director.
*	****(Code C3: adults only; or may be Code C1: both adults and children, though participation of children is limited)***
- 4. Representation of children in specimens or datasets cannot be accurately determined **and**
- 	this does not compromise the scientific objectives? ***(Code C4: children representation unknown)***

*Inclusion policy applies despite exemption*

- NIH/OER April 26, 2001

| Unacceptable

Contact

Scientific Review Administrator |
| --- |

| ABSENT
No Information |
| --- |
# Presentation: 688026

## International Society for Violence and Injury Prevention ISVIP 

## Rationale

## 	ISVIP is becoming a visible international champion in promoting injury prevention and safety promotion. It will provide an opportunity for all relevant stakeholders for global advocacy and the advancement of capacity building in view of injury prevention and research.

## Mission

- ISVIP is dedicated to establishing global commitment to violence and injury prevention through advocacy and public policy action and consequently by enhanced research, education and prevention efforts.

## The goals of ISVIP

- facilitate information exchange, collaborative efforts and partnerships among practitioners, policy makers, advocates and researchers;
- advocate at national and international level for increasing investment in injury and violence prevention and research;
- organize scientific conferences and meetings, particularly the World Conferences on Injury Prevention and Safety Promotion under the agreement established with WHO and the groups of Collaborating Centers;
- promote capacity development for injury and violence prevention and research.

## Members of the board

**Leif Svanström**
- _[Maria Isabel Gutierrez M.](http://interdev2.nchs.cdc.gov/nchs/)_** **
- _[Yousif](http://interdev2.nchs.cdc.gov/nchs/)__[ ](http://interdev2.nchs.cdc.gov/nchs/)__[Rahim](http://interdev2.nchs.cdc.gov/nchs/)_
- _[Francesco](http://interdev2.nchs.cdc.gov/nchs/)__[ ](http://interdev2.nchs.cdc.gov/nchs/)__[Zambon](http://interdev2.nchs.cdc.gov/nchs/)_** **
- _[Carmen Clavel- Arcas](http://interdev2.nchs.cdc.gov/nchs/)_
- _[Lois](http://interdev2.nchs.cdc.gov/nchs/)__[ A. ](http://interdev2.nchs.cdc.gov/nchs/)__[Fingerhut](http://interdev2.nchs.cdc.gov/nchs/)_** **
- _[Alireza](http://interdev2.nchs.cdc.gov/nchs/)__[ ](http://interdev2.nchs.cdc.gov/nchs/)__[Ahmadi](http://interdev2.nchs.cdc.gov/nchs/)_
** ****Thuthukile Goba**

**Simon Bokongo Lokofo Kawaya.**
**Rajam Krishnan **
**Geeta A. Kurhade **
**John Langley**
**Dinesh Mohan**
**Wim Rogmans**
**Babatunde Solagberu**

## 
http://www.isvip.org

**http://www.isvip.org**
# Presentation: 204111

## Ultra-High-Efficiency, Monolithic, Dual-Junction Solar Cells

**ACCOMPLISHMENTS**
-   Developed proprietary, step-graded buffer layer scheme 	that allows the growth of very low defect density, lattice-	mismatched InGaAs on GaAs and InP substrates
-   Fabricated high efficiency, metamorphic, single-junction 	1.1 eV InGaAs, 1.62 eV InGaP, and dual junction           	1.62 eV / 1.1 eV InGaP/InGaAs solar cells on GaAs 	substrates using the buffer layer scheme
**	****	****	****COMMERCIALIZATION**
-   This SBIR served as a basis for an Air Force contract to 	develop a triple-junction, lattice-mismatched solar cell. 	Efficiencies of 25% were achieved with a goal of 31%
-   Private capital from ERI and loans totaling $750K were 	used to establish and operate independent production 	facilities
-   Received $100K from commercial business to date from 	related areas
-   ERI increased employees by 5 to a total of 9 people

***Essential Research, Inc (ERI)***
***Cleveland, OH***

**S****mall**
**B****usiness**
**I****nnovation **
**R****esearch**

**GOVERNMENT/SCIENCE APPLICATIONS**
-   These types of solar cells  will be used by both NASA 	and DOD in various programs
-   A new technology area has been established for multi-	junction cells-the lattice mismatched multi-junction cells

- Glenn Research Center
- Space Power
- 3-086

**Ultra-High-Efficiency, Monolithic, Dual-Junction Solar Cells**

***Dual junction cell structure***

**INNOVATION**

- 1996 Phase II, NAS3-98026, 4/02
- NASA Contact – Dave Wilt/Sheila Bailey
- Company Contact – Samar Sinharoy

- Lattice-mismatched multi-junction high efficiency solar cells
# Presentation: 491014

## Maximizing Airport Operations Using WAAS

**31****st**** Annual Airport Conference, Hershey March 19, 20087**

## What Airport Owners and Consultants Should Know about WAAS

**FAA goal to increase publication of WAAS procedures to 500 per year**
**FAA strives to provide the best approach, and lowest minimums for each WAAS procedure**
**New WAAS procedures at your airport can have a **_**profound**_** affect on Design Standards**

## What Airport Owners and Consultants Should Know about WAAS

**Q:  How much does a free WAAS procedure cost?**

## What Airport Owners and Consultants Should Know about WAAS

**Q:  How much does a free WAAS procedure cost?**
**A:  If you are not careful, more than you got!**

## Typical non-precision RPZ

## Approach upgraded to Precision

## Any new procedure (including WAAS) impacts Airport Design Standards:

**3 Changes that Affect Design Standards: **
- New non-precision approach procedure on runways that were visual approach only
- Existing non-precision approach upgraded to a precision approach
- Significant minimums lowered for existing non-precision approach

## What Should Airport Owners do to Prepare for new WAAS Procedures?

**Understand the affect of a planned new WAAS procedure on your specific airport (Prior Proper Planning),**
**Update the ALP for the new procedure,**
**Survey the approach conditions to know the obstruction or get the best minimums (IAW A/C 150-5200-16, -17, -18)**

## What Should Airport Owners do to Prepare for new WAAS Procedures?

**Do not hesitate to request a change in the procedure (higher minimums, day/night restrictions, etc) to reduce impact until the airport can be improved to standards,**
**Implement improvements to support the new WAAS procedure(s) (buy land, easements, clear obstructions)**

## Questions?
# Presentation: 284413

## 
Dean Perry
Chair - SSG-WI Planning WG

- Dean Perry
- Chair - SSG-WI Planning WG

**National Wind Coordinating Committee**
**Planning Meeting**
**June 3-4, 2003**
**Portland, Oregon**

## Overview

- Overview of SSG-WI Planning work
- How it is related to NWCC Draft Transmission Planning Principles Paper

## What is SSG-WI?

- A seams coordination forum sponsored by the 3 proposed RTOs in the West **(Principle 8.)**
- Steering Group and WGs are open, everyone is ENCOURAGED to participate
- SSG-WI PWG – Those now involved include state agency representatives, resource developers (wind and coal), marketers, IOUs, public utilities **(Principle 2.)**
- RTOs make final decisions and implement

## Organization Chart

** **

** **

**RTO West**

** **

** **

**Principals in Consultation with RRG **

**(Regional Representatives Group)**

**WestConnect**

** **

** ****Interim Committee **

** **

**CAISO**

** **

**Board**

** **

**Seams Steering Group**

** **

** **

- Chair – Bud Krogh

- RTO West
- Frank Afranji
- Rich Bayless
- Yakout Mansour
- Syd Berwager (Alt)

- _WestConnect_
- Charlie Reinhold
- Cary Deise
- Greg Miller
- Ed Beck (Alt)

- _CAISO_
- Elena Schmid
- Steve Greenleaf
- Armie Perez

**Transmission**
**Planning **

** **

- Chair:
- 	Dean Perry

**Congestion  Management Alignment**

** **

** **

- Chair:
- 	Wally Gibson

**Market Monitoring**

** **

- Chair:
- 	Kristi Wallis

**Price Reciprocity**

** **

**Common Systems Interface Coordination (CSIC)**

** **

** **

** **

** **

- Chair:
- 	Don Watkins

** **

** **

** **

- Chairs:
- 	Phil Pettingill
- 	Chris Elliott

## SSG-WI Planning Function

**SSG-WI does transmission Planning (identifies needs, runs studies, identifies solutions)- - conceptual ideas, pre- to early- WECC process ****(Principle 3.)**
**Doing “congestion relief” planning (to expand current capability), not “reliability” planning (to maintain current capability).  Utilize reliability planning of individual entities as input. ****(Principle 7)**
**Focus is on forecasting future uneconomic congestion and developing alternative solutions (transmission and non-transmission)**
**Looking West-wide, not Subregional ****(Principle 1.)**
**Analyze historical congestion – Report on SSG-WI Web Site**

## SSG-WI Planning Function

**SSG-WI supports WECC project review procedures and WECC reliability criteria and standards**
**SSG-WI does not sponsor projects or implement projects**
**SSG-WI will support state siting and permitting processes as requested**
**Plan to issue Annual Transmission Reports – First report scheduled for release in September 2003**

## 2003 Planning Study

- 2008 –
- based upon resources to be on line by Jan 2004 plus others on-line during 2004
- hydro and gas price sensitivities
- Transmission energized by 2008
- Identify potential areas of transmission congestion
- 2013 –
- looking at 3 resource scenarios: coal, renewable, and gas **(Principle 4)**
- hydro and gas price sensitivities
- Identify areas of congestion & evaluate alternative solutions

## SSG-WI Process Chart (DRAFT)
# Presentation: 719954

## Session  4

- Tribally Controlled Colleges
- Open Forum
- Joel V. Harrell, Director
- Special Initiative Service

## Who are we?

- Within the School Services and Training Channel, the Special Initiative Service unit strives to proactively identify the unique needs of Historically Black Colleges and Universities, Hispanic Serving institutions, and Tribally controlled colleges.

## Examples of Services Provided

- Technical assistance in programmatic and administrative areas
- Provide customized training that is developed to meet the unique needs of the institution
- Assists institutions in performing on/off campus assessments and if warranted, the development of corrective actions plans

## Basic Guiding Principles of Assistance

- We are here to help!
- We are not program reviewers or auditors
- Our emphasis is self initiated institutional improvement

## Special Initiative Service

- We appreciate your feedback and comments.
- We can be reached at:
- Phone:  404-562-6295
- Fax:      404-562-6283
- Email:   joel.harrell@ed.gov
# Presentation: 762764

## Overall Summary

**Mark Scott, PhD**

## Working Timeframe–Availability of New Data to FDA  

| Feb 05 | Trial 709: Final, validated data sets, 7 mo median follow up
Trial 709: IDMC survival update, 10 mo median follow up  |
| --- | --- |
| May 05 | Trial 709: Survival in relation to EGFR expression  
Trial 721: Interim survival analysis data
Trial 503: Clinical trial report available |
| Jun 05 | Trial 709: Survival in relation to EGFR mutations 
Trial 709 and Trial 503:Complete submission filed for FDA review  |
| Nov 06 | Trial 721: Final survival analysis |

## AstraZeneca Position

**IRESSA****®**** is an active and well-tolerated agent**
**IRESSA****®**** remains a beneficial treatment option for some patients**
**Trial 709 provides additional information about patient selection**
**Trial 721 can confirm effectiveness of IRESSA****®**
**Ongoing development program will help characterize patients most likely to benefit**
**AstraZeneca has taken the necessary steps to ensure that oncologists are well informed and consider other treatment options**
# Presentation: 235029

## Radioimmunoassay (RIA):A Remarkably Sensitive Bioassay

- Sarah Dekat
- NCSS 2006

## Biochemistry Principles

- <date/time>

## Radioimmunoassay Procedure

- <date/time>

## Standard Curve & Unknown Sample

## Characteristics of Binder and Ligand

- <date/time>

- Availability
- Synthetic
- Natural – Produced From Animals
- Monoclonal Antibodies
- Purity – Competing Reactions with 			Impurities
- Stability – Store in Albumin Serum
- Specificity – Binding Constant

## Characteristics of Tracer

- <date/time>

- Must Have Similar Binding Properties as Unlabeled Ligand
- Internally Labeled Ligand
- 14C and 3H
- Externally Labeled Ligand
- 131I and 125I
- By-Products or Incomplete Synthesis
- Purification by chromatography (gel filtration)

## Separation of Bound and Free Ligand

- Electrophoresis
- Gel Filtration
- Adsorption Chromatography
- Fractional Precipitation
- Centrifugation
- Filtration
- Partition Chromatography
- Dialysis

## Increasing Assay Precision

- <date/time>

## Sensitivity – Decrease [Ligand]

- <date/time>

## Sensitivity – Decrease [Binder]

## Comparison of Assays

- <date/time>

- Enzymeimmunoassays (EIA)
- millimolar
- Fluoroimmunoassays (EIA)
- micromolar
- Radioimmunoassays (EIA)
- nanomolar to picomolar

## Applications of Radioimmunoassays

- <date/time>

- Endocrinology
- Insulin, HCG, Vasopressin
- Detects Endocrine Disorders
- Physiology of Endocrine Function
- Pharmacology
- Morphine
- Detect Drug Abuse or Drug Poisoning
- Study Drug Kinetics

## Applications of Radioimmunoassays

- Epidemiology
- Hepatitis B
- Clinical Immunology
- Antibodies for Inhalant Allergens
- Allergy Diagnosis
- Oncology
- Carcinoembryonic Antigen
- Early Cancer Detection and Diagnosis

## Summary

- <date/time>

- Based on Simple Biochemistry Principles
- Establish Ideal Binder and Ligand
- Synthesize Tracer Ligand
- Separation of Bound and Free Parts
- High Precision and Sensitivity
- Powerful Applications to a Wide Range of Medical Fields
# Presentation: 926658

## FermiGrid Effort Distribution

| ACTIVITY | OPS--FTE | DEV--FTE |
| --- | --- | --- |
| Operations | 1.25 |  |
| Security |  | 0.25 |
| Support | 0.50 |  |
| Outreach |  | 0.25 |
| OSG | 0.25 |  |
| FermiGrid HA Upgrade |  | 0.25 |
| Development |  | 1.75 |
| Storage |  |  |
| Totals | 2.0 | 2.5 |

- Personnel: K. Chadwick, S. Timm, D. Yocum, V. Sergeev, N. Sharma (1/2)

- Keith Chadwick/Steven Timm   Grid Coordination Meeting

- February 27, 2007

## Resource Concerns

- FermiGrid-High Availability
- 	All FermiGrid machines, OS, Middleware currently 9x5 support.
- 	LHC startup is coming soon.
- 	Expect stakeholder requirements for 24x7 support of site services.
- 	Current level of equipment funds not enough to 			complete this project in FY07.

- Keith Chadwick/Steven Timm   Grid Coordination Meeting

- February 27, 2007

## FermiGrid Interfaces with other projects

**FermiGrid effort on behalf of other projects and groups:**
- FEF:
- 	Consult FEF and REX-OPS on conversion of CDF, D0 Farms, CAB, CAF to Grid
- 	Uniform software layout for Grid-ized worker nodes.
- 	Knowledge transfer: Hardware, vendor Eval, legacy Farms operations	Decommissioning legacy farms software FBSNG, DFARM
- CDF:
- 	Consult on gLexec deployment and operations of Condor.
- DES:
- 	Consulting on data movement
- OSG:
- 	User and VO support documentation, shared between FermiGrid group, OSG Docs people, and C. Green.
- Helpdesk:
- 	Get expert mail lists in place for all Fermilab-based VO’s at the Fermilab Grid Support Center
- GRATIA:
- 	Manage OS on GRATIA machines,
- 	Transitioning to a phase where FermiGrid manages production GRATIA service.
**Stakeholders: Projects and VO’s using FermiGrid site services**
- CMS, CDF, D0, SDSS, DES, ILC, AUGER, Neutrino program, OSG, I2U2, Nanohub, LQCD
**Stakeholders:  Projects providing computing resources to FermiGrid**
- CMS, CDF, D0, ILC, MINOS, KTeV, CD.

- Keith Chadwick/Steven Timm   Grid Coordination Meeting

- February 27, 2007
# Presentation: 531307

## Overcoming Forecast Challenges of Complex Terrain: Use of R/WIS to Improve Operations

**Mary M. Cairns**
**Senior Staff Meteorologist**
**OFCM**

## Overview

- Purpose
- Background
- Objectives and Results
- Process
- Keys to Success
- Summary

## Purpose

- Demonstrate how a collaborative effort with funding is essential for transitioning user-based needs (e.g., FHWA) into operational results

## Background

- State Department of Transportation
- >1300 Environmental Sensor Stations [c.2001]
- NWS and FHWA joint research effort
- COMET Request for Proposals
- Partnership project selected
- NOAA/NWS Reno, NV
- Nevada DOT
- University of Nevada Desert Research Institute
- 2 years
- Complex terrain forecasts and NDOT operational challenges
- Can R/WIS help?

## Slide 5

## Objectives and Results

- Objectives
- Improve pavement forecasts through improved model input
- Improve NWS operational forecasts through better model guidance
- Improve operational decisions regarding snow and control operations
- Develop an NDOT public travelers forecast
- Results
- Improved quality of R/WIS data & archival
- Improved issuance and verification of operational forecasts and warnings
- Developed data assimilation system for numerical weather prediction model
- Provided improved guidance to NDOT pavement temperature forecasts

## Process

- Agency defined need and funding
- Partnership
- Mutual goals
- Share and use of RSS data
- Advance regional mesoscale modeling capabilities
- Improve road condition forecasting
- Expertise and enthusiasm
- Technology
- Scientific knowledge
- Results driven

## Slide 8

## Pavement Temperature Model Output

## Keys to Success

- Expertise and enthusiasm
- Test beds or test sites needed
- Includes management of R&D priorities & associated projects
- Adequate funding/resources for all involved
- “Customer” based research with operational result
- Project based on high-impact events
- Collaboration was a learning process
- Leadership support

## Example of Success

**Example of Success**
**California Department of Boating and Waterways**

- MM5 Real-Time Forecasts – Supporting shipping and boating operations
- DRI Atmospheric and Dispersion Modeling Program
- Dr. Darko Koracin, PI

## Summaryaka Purpose revisited

- Demonstrated how a collaborative effort with funding is essential for transitioning user-based needs (e.g., FHWA) into operational results
# Presentation: 438704

## Dr. Heather J. BrownDirector and Associate ProfessorConcrete Industry Management

*A Concrete Example of Integrating Standards*

## Concrete Industry Management (CIM)

- Blend of Engineering and Business courses to bring concrete education to the next level.

## Nationwide Press Articles

- AP article was seen in 104 papers nationwide.
**“****Popular MTSU degree cements industry, academia relationship”**
***Hottest major is concrete management***
- By WILL YORK*Associated Press*Friday, 07/20/07

**Dr. Heather J. Brown, director of the concrete industry management program at **
**Middle Tennessee State University, and MTSU senior Jeremy Mertens **
**examine the student parking lot made of a porous-type concrete that **
**allows water to pass through it.** (PAUL J. LEVY / ASSOCIATED PRESS)* *

**Notes:**
Great press for CIM.  Article seen from Florida to New York to California.  

## Expansion Schools

## CIM Core Courses

- CIM 1010 – Intro to Concrete Industry
- Lecture on ASTM and importance of standards.
- CIM 1050 – Blueprint Reading
- CIM 3000 – Fundamentals of Concrete
- CIM 3050 – Concrete Construction Methods
- CIM 3060 – Construction Systems
- CIM 3100 – Applications of Concrete
- CIM 4050 – Management of Concrete: Order and Delivery
- CIM 4060 – Management of Concrete: Production Facilities
- CIM 4150 – Concrete Diagnosis and Troubleshooting
- CIM 4200 – Concrete Research
- CIM 4910 – Senior Capstone

## “Standard” Practices In CIM

- A compilation of 44 ASTM Standards pertaining to concrete masonry. Specifications on concrete masonry units, mortar, aggregates, grout, flexural bond strength, segmental retaining wall units, paving units.
- A compilation of 38 ASTM related to two ASTM standard specifications for ready-mixed concrete: * C 94 Ready-Mixed Concrete * C 685 Concrete Made by Volumetric Batching and Continuous Mixing.

## ASTM for Materials

**Aggregates**
**Cement**
**Pozzolans** (fly ash, silica fume, shale,
-      calcined clay or metakaolin)
**Slag**
**Water **
**Chemical Admixtures**

## Industry Certifications

**Concrete Laboratory Testing Technician - Grade I***
**12 ASTM’s**
**Concrete Field Testing Technician - Grade I **
**9 ASTM’s**

- Testing Laboratory Technicians
- Contractor Quality Control Personnel
- Architect/Engineer Inspectors
- Ready Mixed Concrete Personnel
- Supplier Sales

## Senior Concrete Research 

**ASTM Volume 04.01: Construction: Cement; Lime; Gypsum**
**ASTM Volume 04.02, Concrete and Aggregates**
**Perform laboratory testing utilizing an ASTM standard**
**Write a technical report referencing ASTM standards **
**Significance of Tests and Properties of Concrete and Concrete-Making Materials (STP 169D)**
**Cement, Concrete & Aggregates** **Journal (2004)**
**Literature review resources**

## ASTM Standards are “set” in CIM

- ASTM Student Membership
- Exposure to over 75 ASTM’s during college
- Tested over ASTM’s for industry certifications
- Evaluate concrete using ASTM methods
- Reference ASTM’s in technical report writing
- Review articles in ASTM journals
- Interact with professors who serve on ASTM committees
-  Thank you – Questions?
# Presentation: 128350

## The Regenerated Diesel Engine

**ACCOMPLISHMENTS**
-  	Several designs have been developed and components 	tested, preliminary to the fabrication and testing of a 	technology demonstrator engine
-  	Analyses indicate exceptional fuel efficiency, very high 	Brake Mean Effective Pressure (BMEP) with low peak 	cylinder pressures, and the potential for reduced 	emissions

**S****mall**
**B****usiness**
**I****nnovation **
**R****esearch**

**GOVERNMENT/SCIENCE APPLICATIONS**
-  	Potential use for general aviation aircraft propulsion and 	shipboard power generation.  Other government stationary 	power generation and vehicular propulsion applications 	are also feasible
-  	Potential commercial applications include stationary power 	generation, truck and automotive, ship propulsion, and 	earthmoving equipment

- Glenn Research Center
- Aeronautics
- 3-083

**The Regenerated Diesel Engine**

**INNOVATION**

- 1994 Phase II, NAS3-27841, 2/02
- NASA Contact – Bruce Bream
- Company Contact – Allan Ferrenberg

- A reciprocating internal combustion engine operating on a regenerated cycle

**The Regenerated Barrel Cam Aircraft Engine**

**COMMERCIALIZATION**
-  	Continuing R&D under several commercial and U.S. 	government (NASA & Navy) contracts
-  	Joint venture arranged with Alvin Lowi & Assoc. for 	development of a barrel cam version of this engine
-  	Strategic partnership developed with Caterpillar, Inc.
-  	On-going R&D and patent development financial and 	technical support from Caterpillar, Inc.

***The ReJen Company***
***Bishop, CA***
# Presentation: 687537

## Integrated StaveElectrical/Mechanics/Cooling Update

- February 6, 2008

## Prototypes and Designs

-  6 x 3 cm, 6 chips wide

- 10 x 10 cm, 10 chips wide

- 1 meter,  3 cm strip, 30 segments/side
- 192 Watts (ABCD chip), ~2.4 % Xo + support structure

- 1 meter, 2.5  cm strip, 40 segments/side
- 200-250 Watts (@0.25 W/chip) ~1.9 – 2.2 % Xo + support

- Stave-07

- Stave-06

- 60 cm, 9 cm strip, 6 segments/side

- Stave-08

- Build and test

- Study

## Issues From Valencia

- Progress on testing and fabrication of Stave-07
- Irradiation of hybrids glued directly on silicon surface
- Thermal performance of bridged hybrid
- Planning for Spring 2008 module review

## Progress on Testing/Fab of Stave-07

- Have operated 5 hybrids in a serial chain with good performance
- Have built and are studying 3 modules with hybrid on the silicon and 1 “reference” module with hybrid off the silicon
- Effort on gluing and alignment procedures implicit in module building
- Bus cable has been submitted for fabrication, due in 1-2 weeks
- Extra clock lines have been added to allow options for clock distribution included 1 clock for 30 module or 1 clock for 10 modules

## Module Assembly and Test Fixture

- volve asingle fixture for assembly, bonding, inspection, and test.

## Bus Cable

- Serial current link

- Serial current
- return

- HV distribution

- Clock &
- Command
- lines

- Data
- Readout
- 1/hybrid

## Irradiation plans

- Irradiations are in planning phase both at BNL and LBNL
- BNL is looking at Boston and Los Alamos sites
- LBNL would use on-site 55 MeV protons
- Hope to have first runs in the next few months

## FEA Models of Bridged Hybrid - I

- Since the Valencia meeting we have completed FEA analysis of basic thermal performance with bridged hybrid
- Multiple models to achieve reliability and understanding
- 1⁄4 simple model, similar to ANSYS model by others, air treated as “solid” under bridge
- 1⁄2 model with air box to allow for 3D air effects (not just under bridge), no air flow

- Air gap

- 1⁄4 model

- Air box for 1/2

- 1⁄2 model

## FEA Models of Bridged Hybrid -II

- Multi-hybrid model

- Multi-hybrid model, with air flow included(so far 0.01 m/sec)
- For simplicity, all studies so far done with tube wall temperature fixed at -28C, 0.25 W/IC and no detector heating.
- Goal is to compare first with glued hybrid under same conditions
- More details are _[here](http://www-physics.lbl.gov/~gilg/ATLASUpgradeRandD/CFD%20Bridge%20Simulation.ppt)_ and _[here](http://www-physics.lbl.gov/~gilg/ATLASUpgradeRandD/New%20QTR%20Solutions.doc)_

## Short Summary

- Good agreement among models
- Modest effect of gas flow
- Reduced K means lower than nominal K in structure. No optimization of structure yet
- For comparison, nominal design (hybrids glued on silicon) for comparable assumptions yields max sensor temperature of about -22.5C

| Model | IC Peak
Temp(C) | Bridge
Gradient(C) | Sensor 
T Max(C) |
| --- | --- | --- | --- |
| 1⁄4 model | -5.8 | 6.6 | -20 |
| 1⁄2 model | -6.3 | 6.8 | -20.2 |
| With air flow
-15C gas | -5.9 | 7.6 | -18.7 |
| 1⁄4 model
Reduced K | 3.4 | 5 | -16.7 |
# Presentation: 803355

## EPIC Web 3.0 Demonstration

**Andrea Robinson**
**Program Analyst, Client Management Branch**
**Government Employees Services Division**

## Agenda

**Introductions**
**EPIC Application**
**Document List**
**Search Criteria**
**New Document Type List**
**Payroll Documents**
**Personnel Documents**
**HCUP Processing**
**Reports**
**EPIC Implementation Schedule**

##           EPIC WEB 3.0

**          ****EPIC WEB 3.0**

##           EPIC WEB 3.0

**          ****EPIC WEB 3.0**

##           EPIC WEB 3.0

**          ****EPIC WEB 3.0**

##           EPIC WEB 3.0

**          ****EPIC WEB 3.0**

##           EPIC WEB 3.0

**          ****EPIC WEB 3.0**

##           EPIC WEB 3.0

**          ****EPIC WEB 3.0**

##           EPIC WEB 3.0

**          ****EPIC WEB 3.0**

##           EPIC WEB 3.0

**          ****EPIC WEB 3.0**

##           EPIC WEB 3.0

**          ****EPIC WEB 3.0**

##           EPIC WEB 3.0

**          ****EPIC WEB 3.0**

##           EPIC WEB 3.0

**          ****EPIC WEB 3.0**

##           EPIC WEB 3.0

**          ****EPIC WEB 3.0**

##           EPIC WEB 3.0

**          ****EPIC WEB 3.0**

##           EPIC WEB 3.0

**          ****EPIC WEB 3.0**

##           EPIC WEB 3.0

**          ****EPIC WEB 3.0**

##           EPIC WEB 3.0

**          ****EPIC WEB 3.0**

##           EPIC WEB 3.0

**          ****EPIC WEB 3.0**

##           EPIC WEB 3.0

**          ****EPIC WEB 3.0**

##           EPIC WEB 3.0

**          ****EPIC WEB 3.0**

##           EPIC WEB 3.0

**          ****EPIC WEB 3.0**

##           EPIC WEB 3.0

**          ****EPIC WEB 3.0**

##           EPIC WEB 3.0

**          ****EPIC WEB 3.0**

##           EPIC WEB 3.0

**          ****EPIC WEB 3.0**

##           EPIC WEB 3.0

**          ****EPIC WEB 3.0**

##           EPIC WEB 3.0

**          ****EPIC WEB 3.0**

##           EPIC WEB 3.0

**          ****EPIC WEB 3.0**

##   EPIC Implementation Schedule

**Integration Testing (May 12 – June 27) **
**User Acceptance Testing (TBD)**
**Super Users Needed**
**Quality Assurance Testing (TBD)**
**Obtain QA Test Coordinator**
**Obtain QA Testers**
**Obtain test SSNs**
**Create/provide test cases**
**Obtain security requirements**
**Production Implementation (Spring 2009)**
# Presentation: 212692

## New Probes for Physics BSM at the LHC P-23, P-25, T-8 and T-16 

- LHC is the premier facility for studies of _Physics Beyond the Standard Model_ and _Matter under Extreme Conditions_ :
- 	p+p collisions @ 14 TeV **** begins 2008
- 		Discovery potential for *BSM Physics - **	**	**	*Supersymmetry, Higgs, Extra Dimensions.* *
- 	Pb+Pb @ 5.5 TeV / A **** begins 2010
- 		Matter under extreme conditions – 				Radiography of the *Quark-Gluon Plasma*
- Experimental signatures for new physics - combinations of 		high energy jets, heavy quarks and muons,			which are each copiously produced at LHC
- Radiography of QGP using -
- 		Pb+Pb  Z0/********+jet, BB+jet or DD+jet  ********+************+ jet

- Pb+Pb

- QGP

- Difference in dimuon and jet
- momenta gives interaction
- with hot, dense matter

- -            -

- SUSY stau (Kitano)

## Experimental Approach

- Use CMS (_Compact Muon Solenoid_) experiment’s excellent muon identification      and calorimetry (for jets)
- FY06 LDRD-ER project studied jet reconstruction and rates for jet tagging at CMS -		Excellent rates, Z0 and jet identification

- Events per year

- CMS

- LANL Simulations,
- C. Mironov

- Full CMS Simulation (Phythia and Geant 4)

## 
LANL capabilities relevant  to CMS / LHC program:
Muon detection and reconstruction (FNAL, RHIC experiments)
Silicon vertex detectors (FNAL, LEP, RHIC), 				for superLHC upgrades in 2013
Large scale computing for event simulation and reconstruction
Theory – T-8 and T-16 expertise in HEP and NP
Long history of DOE funded research in high energy nuclear physics

LHC is future of HEP and High Energy Nuclear Physics programs –
Timely opportunity to establish a new program at LHC, 			p+p collisions beginning next year
Seed money needed to ensure long-term DOE funding for NP program
Explore possible HEP experimental support from DOE

- _LANL capabilities relevant  to CMS / LHC program_:
- Muon detection and reconstruction (FNAL, RHIC experiments)
- Silicon vertex detectors (FNAL, LEP, RHIC), 				for superLHC upgrades in 2013
- Large scale computing for event simulation and reconstruction
- Theory – T-8 and T-16 expertise in HEP and NP
- Long history of DOE funded research in high energy nuclear physics
- _LHC is future of HEP and High Energy Nuclear Physics programs_ –
- Timely opportunity to establish a new program at LHC, 			p+p collisions beginning next year
- Seed money needed to ensure long-term DOE funding for NP program
- Explore possible HEP experimental support from DOE

**New Probes for Physics BSM at the LHC**
# Presentation: 910216

## Slide 1

##                         Hiram  Maxim -  1894

-                         Hiram  Maxim -  1894
- 6000 pound aircraft ,  2  steam engines,  18 foot  props

##                 Otto  Lilienthal

-                 Otto  Lilienthal
- Years  of  Glider  Experiments

-    Killed  in  glider  accident
-                     1897

## Slide 4

## Slide 5

## Slide 6

## Slide 7

## Slide 8

## Slide 9

## Slide 10

## Slide 11

## Slide 12

## Slide 13

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