BEE-spoke-data/govdocs1-by-extension huggingface dataset:
# Presentation: 412935

## Puccinia graminis genome project

- Les J Szabo
- USDA ARS Cereal Disease Lab
- Department of Plant Pathology
- University of Minnesota

## Project team

- Les J Szabo - USDA ARS CDL, UMN
- Christina Cuomo, Broad Institute, MIT
- Ralph Dean, CIFR, NCSU
- Jacquie Schein, Genome Sciences Centre, BC Cancer Agency
- Funding: NSF Microbial Genome Sequencing Program

## Genome Sequencing

*Puccinia graminis* f.sp. *tritici*
- CDL 75-36-700-3 (WA)
- Avirulent to 25 wheat *Sr* genes
*Sr*6, *Sr*7b, *Sr*8a, *Sr*9b, *Sr*9d, *Sr*10, *Sr*11, *Sr*13, *Sr*14, *Sr*22, *Sr*24, *Sr*25, *Sr*26, *Sr*27, *Sr*28, *Sr*30, *Sr*31, *Sr*32, *Sr*33, *Sr*34, *Sr*35, *Sr*36, *Sr*37
- Parent mapping population
- DNA extracted from urediniospores (dikaryotic)

## Genome Sequencing

|  |  | Total reads | Q20 Bases | Q20 Coverage |
| --- | --- | --- | --- | --- |
| 4kb plasmid |  | 987,589 | 659,546,740 | 8.24 |
| 10kb  plasmid |  | 393,270 | 242,470,558 | 3.03 |
| 42kb fosmid |  | 231,339 | 102,265,696 | 1.28 |
| Totals |  | 1,612,198 | 1,004,282,994 | 12.55 |

## Draft assembly

- Contig size: 81.5mb
- Super contig size: 88.6mb
- Gaps: 7.96%
- No. contigs: 4,557
- No. supercontigs: 392
- Percent reads: 60%
- Q20 coverage: 6.8X

## Restriction Fingerprint Map

- PstI/EcoRI double digest
- Ave. fosmid size: 40.2kb
- Ave. number of fragments: 19.4
- Number of clones in map: 22,249
- Estimated clone coverage: 10.8X
- Estimated genome size: 94mb
- Number of contigs: 1,969
- Number of singleton clones: 729 (3%)

## Restriction Fingerprint Map

## ESTs

| cDNA library | Filtered sequences | Average length  | Clones | Clones w/2 ends |
| --- | --- | --- | --- | --- |
| Urediniospores | 16,651 | 700 | 9,980 | 8,046 |
| Germinated urediniospores (24r) | 22,550 | 688 | 12,070 | 10,480 |
| Teliospores | 18,026 | 695 | 9,236 | 7,325 |
| Total | 57,137 |  |  |  |

## ESTs preliminary analysis

- 3,442 ESTs
- Urediniospore - 1,149
- Germinated urediniospores - 1,146
- Teliospores - 1,147
- 1,632 unigenes
- 457 contigs
- 1,175 singleton
-  325 unigenes could be annotated
- 20%

## Assignment of unigenes

## Assignment of unigenes

## Summary

- 12X genome sequence
- Draft assembly released Jan 2007
- Restriction fingerprint map and assembled genome sequence are highly similar (99%)

## Summary

- 57,000 EST reads
- Three libraries
- Urediniospores
- Germinated urediniospores (24hr)
- Teliospores
- Preliminary analysis of 3,300 ESTs
- 1,632 unigenes
- 325 were able to be annotated
- Each of the three libraries represent distinctly different sets of transcripts

## People

- USDA ARS CDL, University of Minnesota
- Les J Szabo
- Jerry Johnson
- Charlie Barnes
- Kim-P. Nguyen
- Broad Institute, MIT
- Christina Cuomo
- CIFR, NCSU
- Ralph Dean
- Doug Brown
- Funding: NSF Microbial Genome Sequencing Program

- Genome Sciences Centre, BC Cancer Agency
- Jacquie Schein
- University of Hawaii
- Shaobin Zong
# Presentation: 921231

## Overview of Radiological Protection in the Department of Energy

- Joel Rabovsky, Ph.D., CHP
**Office of Health and Safety**
**U.S. Department of Energy**
**DOE Radiation Protection Workshop**
**November 2007**

## Key Programmatic Events1990 -2006

- Key Programmatic Events1990 -2006

**Rad Con **
**Manual**

**Independent Oversight**

**10 CFR 835**

**PAAA**
**Enforcement**

**Occurrence Reporting **

- Production

- D & D

- Radiological Protection Workshop

## Monitored Individuals

- 1990 - 2006

- All monitored workers

- Workers with measurable dose

- Radiological Protection Workshop

## Average Measured Dose 

- Average Measured Dose
- 1990 - 2006

- Radiological Protection Workshop

## Doses Greater than 

- Doses Greater than
- 2 and 5 Rem 1990 - 2006

- Radiological Protection Workshop

## Collective Dose

- 1990 - 2006

- Internal

- Total

- Neutron

- Photon

- Radiological Protection Workshop

## Slide 7

- Radiological Protection Workshop

## Average Measurable Dose

- Six Sites  1990 -2006

- Radiological Protection Workshop

## Collective Dose

- Six Sites 1990 - 2006

- Radiological Protection Workshop

## Collective Internal Dose

- Six Sites 1990 - 2005

- Radiological Protection Workshop
# Presentation: 682274

## Intercity Bus Security Grant Program (IBSGP)

- Funding Amounts for FY06, FY07 and FY08

## FY08Tier IFunding Amount: $6,158,606

- Passenger Screening 18%

- Facility Security Enhancements 23%

- Training and Exercises 2%

- Vehicle Security Enhancements 57%

## FY08Tier IIFunding Amount: $5,013,644

- Vulnerability Assessments and Security Plans 3%

- Facility Security Enhancements 33%

- Training and Exercises 11%

- Vehicle Security Enhancements 53%

## FY07Tier IFunding Amount: $8,159,337

- Passenger Screening 20%

- Facility Security Enhancements 28%

- Training and Exercises 12%

- Vehicle Security Enhancements 40%

## FY07Tier IIFunding Amount: $3,480,663

- Emergency Communications 2%

- Facility Security Enhancements 55%

- Training and Exercises 20%

- Vehicle Security Enhancements 21%

- Public Awareness and Preparedness 2%

## FY06 Funding Amount: $9,503,000*

- Emergency Communications 1%

- Facility Security Enhancements 48%

- Training and Exercises 1%

- Vehicle Security Enhancements 50%

- *No tier differentiation in FY06
# Presentation: 712841

##    Department of Homeland Security

**Increasing Employment of Individuals   with Disabilities**

**Notes:**
Introduce Tanya

## Department of Homeland Security

- DHS is committed to integrating people with disabilities into the homeland security effort

## In The Beginning

**November 25, 2002**: President Bush signed the Homeland Security Act into law.
**March 1, 2003**: Transfer of 22 agencies to form the Department of Homeland Security
- June, 2003: DHS entered a partnership with the Department of Defense’s Computer and Electronic Assistance Program (“CAP Program”) to provide assistive technologies to employees with disabilities.

## Top Level Support

- Secretarial Memorandums
- February 17, 2004
-  July 25, 2005
- Meetings with National Disability Rights Advocates
- Meetings with Under Secretaries
- Appointment of Selective Placement Coordinators (SPC)

## DHS Commitment

- Created the Listserv to widely disseminate DHS headquarters vacancies
- Established DHS Disability Employment and Accessibility Council (DEAC)
- Developed Partnership with Disability Networks
- Leveraged Component Activities
- Development of Component Strategic Plans

## Accomplishments

- Trained Managers and Supervisors
- Hired interns hired, 2 offered full-time employment
- DHS received electronic accommodations from CAP
- DHS honored by CAP as a Model Large Employer for People With Disabilities
- CAP Award*: Real Solutions for Real Needs*
- Highest number of mentors from a non-DOD agency participating in National Disability Mentoring Day

## Accomplishments

- DHS Participated in the pilot that launched DOD’s Operation Warfighter (OWF)
- DHS commitment to OWF

## Point of Contact

- Tanya Cantrell
- 	Office for Civil Rights and Civil LibertiesU.S. Department of Homeland Security (202) 357-8181 Voice
-   (202) 357-8341  FAX
-  (202) 357-8352 TTY
# Presentation: 000713

## Electrochemical Water RecoveryUmpqua Research Company

-  Myrtle Creek, OR

- Commercialization
- Funding for life support related to long-term manned space
-      habitation  will dictate the rate of commercialization.
- NASA represents the immediate market.
- Support for ECWR is anticipated through NASA Contractors
- Private funding is being sought for ECWR treatment of marine vessel and other biological waste water discharges.
- Private funding is being sought for Regenerable Foam Suppresser use in laundry, carwash and other foam intensive applications

- Government/Science Applications
-    Space Station requirement for composite waste water
-      remediation.
-    Long duration space flights requiring Regenerative Life
-     Support Systems.

- Points of Contact:
-   -  Jane I Fox, 281-483-4815
-   -  Umpqua, umpqua.hq@fpioneer-net.com
-   1989 SBIR Phase II; NAS 9-18528 SS # 09-18

- Johnson Space Center
- August 12, 1999
- SS # 9-019

- Accomplishments
-    Successful integration of electrolysis, electrodialysis, and catalytic
-     oxidation to produce potable water directly from composite waste water.
-    Application of a regenerable soap sorbent to control foam formation.
-    Developed products; ECWR and Regenerable Foam Suppresser.
-    Contact with Boeing, KRUG,
-    Station life Support Systems is ongoing.

- Innovation
-    Electrochemical water recovery (ECWR) process for the recovery
-     of portable water from urine and other composite waste water.

- Electrochemical Water Recovery
# Presentation: 697547

## Grid Optimization Tools for Complex Structural Models ResearchSouth, Inc.Huntsville, AL

**Innovation**
- A computer software package for optimization of finite        element meshes for application to structural analysis                   of aerospace components.

**Accomplishments**
- Development state -- production runs
- Software fully operational.
- Software sales pending ($100,000).
**Commercialization**
- Trademark name:  OptiMeshTM
- The following are primary target/potential market sectors:  software sales, research and development companies, and aerospace companies.
- The software’s competitive advantage is that it’s the only software package available for optimization of arbitrary finite element meshes for structural and/or fluids codes.

**Government/Science Applications**
- Actual applications:  Design of space craft sub-structures; missile and rocket systems analysis
- Potential application:  New launch vehicles
- Product being used for launch vehicles and defensive missile systems.
- Awarded Phase III project valued at $145K by NASA Langley Research Center (LaRC).

- Global Menu Window for Meshing Software

- Points of Contact:
-    -  NASA (Denise Swain; 256/544-8112)
-    -  ResearchSouth (Lawrence Spradley; 256/721-1769)
- 1992 SBIR Phase 2; NAS8-40164

- Marshall Space Flight Center
- Date of Update:	9/28/98
- Success Story #:	8-024
# Presentation: 689207

## FHA’s Energy Efficient Mortgages

## Purpose of the EEM

- To Help Achieve the National Energy Goals
- To Help Create Affordable Housing

## What is an Energy Efficient Mortgage?

- A borrower can finance 100% of the cost  of an eligible cost effective energy package
- The property does not need to be re-appraised
- The borrower does not have to be qualified with the additional mortgage mount
- The greater of 5% of property value (not to exceed $8,000) or $4,000 can be added onto the approved mortgage amount

## What is an EEM

- Cost effective - the present value of the energy saved is MORE than the cost of the energy package (including maintenance)
- The maximum mortgage amount for an area can be exceeded by the amount of the energy package

## EEM vs. EEH

- EEM is a mortgage product adding additional dollars to the loan amount.
- EEH is a house built to 2000 IECC.
- EEH allows for ‘stretch ratios’ when qualifying the borrower.

## What Properties Are Eligible?

- 1- 4 units
- Existing construction
- New construction
- SF, townhouses, condos, manufactured houses, duplexes

## What FHA Loans Can Be Used?

- 203(b)
- 203(h)
- 234
- 203(k)
- Purchase or Refinance, including streamline refinance

## Who Can Get an EEM?

- Owner-occupants
- Non-profits

## The Home Energy Rating

- An analysis of the present energy usage and the proposal of an energy package designed to improve energy efficiency.
- A physical inspection of a house, generally including diagnostic tests.
- A computer analysis.

## Home Energy Rating

-  Existing construction
- Compared to a  reference house built to 2000 IECC
- New construction
- Rated from plans and specs
- Compared to 2000 IECC home
- Energy package - those improvements over 2000 IECC

## Who Does the Home Energy Rating?

- A HERS (home energy rating system) provider
- An energy consultant
- A utility
- A governmental agency
- A non-profit experienced in energy ratings
- An entity approved by local, state, or federal government to provide ratings

## The Energy Package

- A combination of energy improvements that are cost effective.
- HERS report outlines improvements, costs and energy savings.
- All items in energy package must be completed.
- Approved changes are OK if the revised energy package is still cost effective.
- Fee can be included in the Energy Package.

## Loan Limits

- Statutory mortgage limit can be exceeded by the amount of the EEM.

## Getting the Work Done

- Borrower should get bids before closing
- EEM dollars are put into a  non-interest bearing escrow account - or if  combined with a 203(k), put into the Rehab Escrow Account
- 90 days to complete work (6 months if a 203(k))
- Contractor cannot be Rater or HERS

## Getting the Work Done

- Post test/compliance inspection when work is complete
- If work is OK and meets PV test, money is released
- If the work does not meet the PV test, borrower will have to re-do or add  improvements
# Presentation: 945662

## Columbia River 

- Case Study

## Columbia Basin 

*Thelin and Pike 1991, USGS Map I-2206*

- Columbia Basin

**Notes:**
Relief Map of the United States illustrating the Columbia River Basin. 

## Columbia Basin - 1905 

**Columbia Basin - 1905**_ _
- _Rivers of North America: A Reading Lesson for Students of Geography and Geology_, by Israel C. Russell, New York, G.P.Putnam’s Sons London, John Murray 1905

**Notes:**
Relief Map of the United States illustrating the Columbia River Basin. 
1905 Map of the United States illustrating the Columbia basin

## Slide 4

**Notes:**
Recent Map of the Columbia River Basin illustrating river control structures. 

## Slide 5

**Notes:**
Cartoon map of Columbia basin illustrating extent of basin

## Waitsburg WA

- Map – Microsoft MapPoint

**Notes:**
Map of the City of Waitsburg WA.

## Tualatin/River/Lake Oswego/Portland OR

- Map – Microsoft MapPoint

**Notes:**
Map of the southern Portland Oregon area.

## Slide 8

**Notes:**
Map of Johnson Creek in Southern Portland Oregon.

## The Dalles OR (Mill Creek)

- Map – Microsoft MapPoint

## Lewiston/Clarkston ID

- Map – Microsoft MapPoint

**Notes:**
Map of Lewiston and Clarkston ID.

## Oregon City OR

- Map – Microsoft MapPoint

## Flood Basalt

- Fix

**Notes:**
Map of Columbia basin illustrating flood basalts.
# Presentation: 344286

## Polymer-Based Nanocomposites: 

- An Opportunity for Deaf and Hard of Hearing StudentsPeggy Cebe, Tufts University, DMR-0406127

- Nanocomposites are mixtures of two or more components, in which at least one of them has dimensions on the nanometer length scale.  In this program, polymer nanocomposites are made by adding tiny particulates to thermoplas-tic polymers. Addition of clay caused changes in both the crystal phase and the microstructure of the nanocomposites.
-      The top figures show polarizing optical microscope (POM) images of polymer crystal aggregates, called spherulites, for 0.07% clay in poly(vinylidene fluoride) polymer matrix, at two different times during growth at 150C.  The diameter of the spherulites was measured and plotted against time (lower figure).  Two types of spherulites could be grown at this temperature: larger, highly birefringent alpha phase (red squares) and smaller, darker ones (blue circles).  The two types nucleate at about the same time, but the alpha phase spherulites grow at a faster rate.

-        Data are from work of Ince-Gunduz, B. S.; _Alpern, R_.; _Amare, D_.; Cebe, P.; _Crawford, J_.; _Dolan, B_.; _Jones, S_.; _Kobylarz, R_.; and _Reveley, M_., in preparation for submission.
*Undergraduates participants are underlined*.

## Polymer-Based Nanocomposites: 

- An Opportunity for Deaf and Hard of Hearing StudentsPeggy Cebe, Tufts University, DMR-0406127

- Four deaf or hard of hearing students were accepted into the third class of interns, and spent six weeks at Tufts, performing research in the laboratory of Prof. Peggy Cebe.  Interns came from Drexel U. (D), Gallaudet U. (G), and Rochester Institute of Technology (RIT).   a.) Michelle Koplitz (RIT) takes POM images. b.) L-R: Front row signs “PB-NC-20-06”: Matthew Meleski (G), Michelle (RIT), Kristina Burke (G) and Ari Sagiv (D); Second row: Wendy Jehlen and Mark Riley, ASL interpreters; Seyhan Ince-Gunduz, Bob Guertin, and Peggy Cebe, instructors. c.) Kristina (G) loads a sample into the FTir cell.

**d**

**Education and Outreach to the Deaf and Hard of Hearing**

**c**

**a**

**b**

- d.) Interns from 2004 and 2005 pose in front of their poster with Prof. Cebe (right).  They  presented at the American Chemical Society meeting, which was held in Washington, DC.
# Presentation: 460644

## CME Data Collection Assignment Matrix

**CME Data Collection Assignment Matrix**
***“******The Collective”***

- EE

- DP

- SC

- LBNL

- EM-50

- RL

- FE

- NE

- NN

- Non-
- EM-50

- FETC

- CHO

- OAK

- SR

- ORO

- SRTC

- PNNL

- LLNL

- P. Jenkins

- AL

- ID

- INEEL

- SNL

- LANL

- CFO

- NREL

- GO

**M. Walsh**

**S. Baker**

**L. Romero**

- M. Coleman

**D. Low**

**T. Vought**

**B. Garland**
- B. Brewer

- B. Dulin

**S. Binkley**

**J. Felton**
- K. Korn

**E. Baroni**
**G. Louie**

**S. Binkley**
**L. Lininger**

**J. Porter**
**L. Liles**

**R. Hirsch**
**C. Bolton**
**B. Kirchhoff**
- W. Ferrell

- TBD - EE

**G. Peabody**
- J. Anderson

- Controller

- HQ Pgm.
- Agent

- Ops./Fld.
- Off. Agent

- Lab
- Agent

**Legend**

- Other
- Agent

- CIO

- ANL

- BNL

**R. Blogg**

**R. Melucci**

- OSTI

**S. Johnson**
**M. Gilbertson**

- N. Tomford

**D. Henderson**
**D. Gottholm**

- ORNL

**M. Leuze**
**B. Kendrick**
- M. McNeeley

**D. Biancosino**

- M. Gilbertson
- J. Beard

- M. Schofield

**M. Fox**

- L. Lanes

- S. Morrell

- SLAC

**M. Thompson**

**NOTE:****	****Bold Text Indicates SIM Participants**
- 	Non-Bold Text Indicates SIM Advisors

- J. Bartell

- TBD-EE
# Presentation: 708382

## Introducing...

***8(a) STARS***
***Streamlined Technology Acquisition Resources for Services***

*GSA is pleased to introduce its newest small business contract vehicle set-aside exclusively for 8(a) technology firms. *
*8(a) STARS **is a multiple award, indefinite delivery indefinite quantity contract vehicle designed to provide cutting-edge technology solutions to federal agencies worldwide. *
**Features**
- 3-year base with two, two-year option periods
- 8 distinct functional areas designated by the North American Industry Classification System (NAICS)
- Directed task orders up to $3 million
- Section 803 compliant
- Non-protestable task orders
- Worldwide geographic coverage
- $15 billion program ceiling
**Benefits**
- Hardware, software, and services may be procured as part of an integrated solution
- Support small business and meet procurement preference goals
- Pre-competed, easy to use contracts
- Short procurement lead time
- Specialized technology contract administration support
# Presentation: 792448

##            PURPOSE OF PRESENTATION 

- 	**THE PURPOSE OF THIS PRESENTION IS TO CLARIFY THE KEY GUIDANCE DOCUMENT CRITERIA THAT IS NEEDED FOR PROCESSING THE PRIA FEE WAIVER REQUEST SUBMISSIONS**

## PRIA FEE WAIVER DOCUMENTATION 

- 	**WHAT DOCUMENTION IS NEEDED TO OBTAIN A VOLUNTARY SMALL BUSINESS FEE WAIVER/ REDUCTION?**
**	***** Please note that the document requirements have not changed from PRIA 1.**

## WHAT INFORMATION SHOULD YOU INCLUDE IN YOUR REQUEST FOR A FEE WAIVER?

**VOLUNTARY SMALL BUSINESS CERTIFICATION FORM FOR PESTICIDE REGISTRATION FEE WAIVER /REDUCTION SIGNED BY THE APPROPRIATE OFFICIAL.**
**COMPANY’S FINANCIAL DOCUMENTATION.**
**COMPANY’S OWNERSHIP STRUCTURE CHART AND EXPLANATION REGARDING THE PARENT COMPANY AND SUBSIDIARIES.**
**GLOBAL GROSS REVENUE FROM PESTICIDES.**
**COMPANY’S NUMBER OF EMPLOYEES.**

## WHAT INFORMATION IS BE OMITTED?

**APPROPRIATE SIGNATURES ON THE CERTIFICATION**
**The Agency requires either the President, Vice President, **
**Or Comptroller’s signature on the form.  The Agency can **
**not accept an Agent’s signature.**

**Notes:**
The Certification form should be signed by the President, Vice President, Comptroller.  Please do not have the Agent sign for you, we can not accept this.
We need the last three years of taxes, front page only.  If the tax forms are not included in the package, this holds up the process time; we need to come back to you.
Ownership structure shows us the relationship between the applicant and other entities, including parent and subsidiary entities.
Global gross revenue is not limited to revenue from pesticides for which the applicant is the registrant, but includes all revenue from the distribution, or sale by the applicant or any of its affiliates of a substance that is intended for pesticide use.
Supply us with a 941-2 tax withholding form.  This verifies all employees.

##  COMPANY’S FINANCIAL INFORMATION

**THE COMPANY’S FINANCIAL INFORMATION SHOULD **
**INCLUDE THE FOLLOWING:**
**	****TAX FORMS FOR LAST THREE (3) YEARS**
**   ****941-2 WITHHOLDINGS**
** ****	****COMPANY FINANCIAL REPORT **
**   ****AUDITED FINANCIAL STATEMENTS  **

## OWNERSHIP STRUCTURE CHART

**THE OWNERSHIP STRUCTURE CHART SHOULD **
**SHOW ALL THE ENTITIES RELATED TO THE **
**APPLICANT, EITHER DIRECTLY OR THROUGH A **
**PARENT OR SUBSIDIARY ENTITY. **

## 	   GLOBAL GROSS REVENUE

**INFORMATION REGARDING THE GLOBAL**
**GROSS REVENUE FROM PESTICIDES OF THE **
**APPLICANT AND AS WELL AS ANY AFFILIATES.**
**THE APPLICANT SHOULD DIFFERENATE THE **
**GLOBAL GROSS REVENUES FROM PESTICIDES **
**FROM OTHER GROSS REVENUE FOR ITSELF **
**AND FOR ITS AFFILIATES, IF ANY.**

## 	NUMBER OF EMPLOYEES

**	****INFORMATION**** ****REGARDING THE NUMBER OF**
**	****EMPLOYEES AT TIME OF APPLICATION.  THE **
**	****NUMBER OF EMPLOYEES IS LIMITED TO THE **
**	****THE EMPLOYEES OF THE APPLICANT AND DOES NOT INCLUDE THE EMPLOYEES OF AFFILIATES.**

## 	Contact  Information

- BEVERLY SJOBLAD
- Phone:  703-305-7560
- E-mail Address:  sjoblad.beverly@epa.gov
- Website:
- http://www.epa.gov/pesticides/fees/
# Presentation: 248189

## Active Surveillance Using Longitudinal Data: A Pilot Project 

**Drug Safety and Risk Management**
**Advisory Committee Meeting**
**Silver Spring, Maryland**
**May 18, 2005**
**David J. Graham, MD, MPH **
**Office of Drug Safety**

**Center for Drug Evaluation and Research**** **

## Background

**Multiple potential approaches**
**Drug based**
**Outcome based**
**Setting based**
**Variety of statistical methods**
**Proportional reporting ratios**
**Bayesian approaches**
**Generally non-longitudinal**

## Project Concept

**Most pharmacovigilance - spontaneous reports**
**No denominator**
**Underreported numerator**
**Datamining for signals**
**Develop population-based ADR screening**
**Longitudinal**
**Prospective**
**Real-time signal detection in longitudinal data**
**Value of “+” signal**
**Value of “-” signal**
**Two complementary statistical techniques**

## HMO Research Network

**Consortium of 10 HMOs**
**~11 M enrollees**
**CERT funded by AHRQ**
**Record-linked**
**Hypothesis testing**
**3 HMOs also FDA funded**

## Sequential Probability Ratio Testing

**Periodic analysis as data accumulates**
**Sequential measurement of signal strength**
**Statistically based**
**Can adjust for automated covariates**

## Weekly cohorts of exposed individuals, each cohort followed for 30 days

**Notes:**
This is a great slide!

## Rotavirus vaccine and intussusception

**Rotavirus vaccine and intussusception**

- (10x)

- Licensed 8/9815 VAERS reports through 7/7/99

- Immunization halt

- Withdrawn

- (1)

- (1)

- (1)

- (2)

- (1)

- (1)

## Tree-Based Scan Statistic

**Use with hierarchical data**
**ICD-9, MeDDRA, drug classification systems**
**No *****a priori***** assumptions re: associations**
**Sequentially moves up tree**
**At each “cut”, evaluates all combinations**
**Adjusts for multiple comparisons**
**Identifies combination with maximum likelihood**
**Two approaches**
**All drugs c/w specific ADR**
**All ADRs c/w specific drug**

## Hierarchical Data

**Drug**
**All drugs**
**     ****Analgesics**
**     ****Non-narcotic**
**         ****NSAIDs**
**             ****Class of NSAIDs**
**                 ****Specific**** ****NSAID**
**ADR event**
**All events**
**     ****Gastrointestinal**
**           ****Hepatobiliary**
**                ****Liver**
**                     ****Hepatitis**

## Tree-Based Scan Statistic

## Current and Future Goals

**Pilot test candidate drugs and ADR events**
**Using retrospective data**
**Known and unknown relationships**
**Internal consistency, external validity**
**Sensitivity, specificity**
**Modify for prospective pilot surveillance**
# Presentation: 444363

## Bugging the Bugs

- Microbial Geneticist Bonnie Bassler:
*Investigating Bacterial Communications*

## Bonnie Bassler Is a Spy

*Bassler, a bacterial geneticist at Princeton University, eavesdrops on bacteria.*

- The bacteria Bassler investigates
-  Float freely in oceans
-  Coat fish, coral, and debris
-  Glow in the dark

*Question*:
- What word describes bacteria that glow in the dark?

## Answer: Bioluminescent	

- Luminescent bacteria can make seafood glimmer    **blue-green****.**

- Next time you see raw fish, turn out the lights and check out the glow!

## Vibrio harveyi bacteria (V. harveyi) 

- Only glow when they are in a sufficiently large group (known as a _quorum_)

## Quorum Sensing 

## How Harmful Bacteria Use Quorum Sensing 

*How Harmful Bacteria Use Quorum Sensing*

- These changes culminate in an infection that can ambush and overwhelm our immune system defenses.

- The bacteria appear relatively innocuous as they quietly grow in number.

- When their population reaches a certain level, instant changes occur in their
-   Behavior
-   Appearance
-   Metabolism

## More About Quorum Sensing

- Bacteria leak a chemical into their surroundings.
- Independent, solitary bacterial cells become part of a large, multicellular organism, known as _biofilm_, when the amount of a certain chemical reaches a particular level.

- What do we call such chemicals?

- Give an example of a common biofilm.

## V. harveyi Are Bilingual

*V. harveyi* communication systems

## The Chain of Command in Bacterial Communication

## Decoy Molecules?

- AI-2 contains the element _boron_

- AI-2 and similar boron-containing molecules made in the laboratory could serve as decoys to subvert virulence and other quorum-sensing behaviors

- Autoinducer 2 may hold the key to disrupting quorum-sensing.

## Research Applications

- 	In what ways might the knowledge that Bassler has gained about bacterial quorum-sensing be applied in human medicine?
# Presentation: 169146

## Slide 1

## Slide 2

## Slide 3

## Slide 4

## Slide 5

## Slide 6

## FCAA08

**FCAA08**

- FCAA08 is defined by the western boundary of ZDC *and a line across central Virginia*.
**Altitude Filters:  **120 – 600
**Arrival Filters:  **ZNY, ZBW, **ZDC**
**Departure Filters:  **None
**Likely weather for use:  **Weather in the Ohio Valley region or in ZDC airspace.
**Weather Triggers:  **Lines and popcorn storms.  CCFP predicted intensity levels of greater than 50% with High Confidence.

**NESP Rate Guidelines  **
- Flow through ZDC:
- Low Weather Impact:	135 – 145 Rate/Hour
- Med Weather Impact         	125 – 135 Rate/Hour
- High Weather Impact	115 – 125 Rate/Hour

**FCAA08**

## FCAA08 – filters, triggers and rates same as FCAA06

- FCAA08 is defined by the entire western and southern boundary of ZDC *and a line across central Virginia.*
**Altitude Filters:  **120 – 600
**Arrival Filters:  **ZNY, ZBW, **ZDC**
**Departure Filters:  **None
**Likely weather for use:  **Weather in the Ohio Valley region or in ZDC airspace.
**Weather Triggers:  **Lines and popcorn storms.  CCFP predicted intensity levels of greater than 50% with High Confidence.

**NESP Rate Guidelines  **
- Flow through ZDC:
- Low Weather Impact:	135 – 145 Rate/Hour
- Med Weather Impact         	125 – 135 Rate/Hour
- High Weather Impact	115 – 125 Rate/Hour

**FCAA08**

- Boundary Points:
- 3910N/08024W
- 3738N/08047W
- 3735N/07719W
- 3756N/07301W

## FCAA08 – from the 7/2 OIS/webcoversheet
# Presentation: 761379

## Improving Cancer Outcomes for African Americans

- Update for RTOG in Miami
- Jan 20, 2006
- Patrick D. Maguire, MD
- New Hanover Regional (NHRMC)

## Update for NHRMCJanuary 20, 2006

- I.	Radiotherapy (RT) Clinical Trials
- II. 	Publications
- III.	Partnership & Telesynergy
- IV.	Patient Navigation & Outreach

## RT Clinical Trials at NHRMC

- CALGB 30206 – Small Cell Lung
- RTOG 0214 – PCI, Advanced NSCLC
- RTOG 9804 – Good Risk DCIS
- NSABP-B35 – Tam vs. AI, DCIS
- CALGB 99809 – B + EB, Prostate (Closed)
- RTOG 0232 – B _+_ EB, Prostate
- RTOG 9811 – Anus (Closed)

## RT Clinical Trialsat NHMRC

- S – screened & eligible
- E – enrolled
- U – underserved (AA &/or poor)

## RT Clinical Trials Accrual Total/2005

- _Trial_			_S_		_E_		_U_
- SCLC			4/3		1/1		0
- PCI, NSCLC		6/5		2/1		0
- DCIS, 9804		11/4		3/2		3/2
- DCIS, B35		-/10		3	        2

## RT Clinical TrialsAccrual Total/2005

- _Trial_			_S_		_E_	  _U_
- Prostate, 99809	7/2		2/1	  2/1
- Prostate, 0232	-/1		0	  0
- Anus, 9811		3/-		2	  2
- H&N, Z0204		18/9		14/8	  0/3

## RT Clinical Trial Accrual

**	****	**_**S**_**	****	**_**E**_**	****	**_**U**_
- Total		60		27		12
- 2005 		34		16		8

## Publications: Manuscripts

- Maguire, Meyerson, Neal, et al, Toxic Cure: hyperfractionated radiotherapy with concurrent cisplatin and fluorouracil for stage III and IVa head and neck cancer in the community.  IJROBP 58: 698-704, 2004.
- Hamann, Kotwall, & Maguire, The role of an AHEC in developing a model program to reduce cancer disparities.  National AHEC Bulletin XXI: 39-40, 2005.
- Johnson, Race, health, and anti-white prejudice: the influence of chronic and temporary accessibility of anti-white stereotypes on black healthcare responses.  J Person Soc Psych, manuscript under review.
- Hamann & Bost, Black-white differences in the influence of cancer experiences on religious beliefs and healthcare satisfaction.  Manuscript in preparation.

## Publications: Abstracts

- Hamann, Maguire, Bost, et al.  Interactions of race, cancer knowledge and beliefs, religious beliefs, and perceived racism an cancer treatment decisions.  ASTRO, Denver, 10/05
- Hamann, Bost, Johnson, et al.  Measuring the influence of cultural and social factors on cancer treatment decisions.  Am Eval Assoc, Toronto, 10/05
- Bost & Hamann.  Effects of cancer on cultural and social beliefs.  Intercultural Cancer Council, Washington DC, 4/06
- Maguire & Rosenman.  Bridging academic and community radiation oncology treatment planning.  Am Telemed Assoc, San Diego, 5/06
- Maguire & Honaker.  A Year of Telesynergy in Southeastern North Carolina.  Am Telemed Assoc, San Diego, 5/06.

## Partnership with UNC-CH& Telesynergy

- Relationship remains strong!
- Visits ~Q4 months
- Telesynergy Qweek
- H&N planning IMRT
- Tumor Board
- ZCC 00204 Trial – UNC opens 2/06
- Upcoming Trials

## Patient Navigation & Outreach 2005

- Our new navigator is LaSonia Melvin!
- Patients Navigated:
- Total = 48
- October-December, 2005 = 24
- Outreach Sessions:
- Total = 27
- October-December, 2005 = 13
# Presentation: 704312

## MC plans in Top group

- Un-Ki Yang
- Univ. of Chicago
- Simulation meeting, May 20, 2004

## Basic Strategy

- 4.9.1 MC request is done.
- 5 cross sections results with 4.9.1 MC are underway for publications.
- 5 top mass results with 4.9.1 MC, but publPication will be with 5.3.2 MC.
- Many other analyses to study top properties were done with 4.9.1 MC
- Top group is now moving toward 5.3.2 MC production.
- Follow our 4.9.1 MC strategy (full CPU+filter+HEPG study+recycling)
-          ( statistics in 4.9.1MC samples are fine for most of MC samples except few )
- New features for 5.3.2 MC
- MC sets with different silicon/beam lines (runs with 100nb-1 	          or 20 represntive runs?)
- Trigger simulation, CMUP18, CEM18 etc.
- Hadronic channels for W, tau decays are included (no more e/mu filter)
- Highest priority: top mass MC samples, major bcks MC samples (W+3/4 P)
- Many top signal systematic samples: lower priority.
- ALPGEN W/Z+jets and bb MC will be recycled (takes HEPG bank for simulation), new version of  ALPGEN for Wbb/cc+Njets generation later.
- Mrenna’s MadGraph sample for major background processes.

## Top signal MC

| Process | generator | Gen evts | Acc. evts |
| --- | --- | --- | --- |
| ttbar | HERWIG | 1M | 2.5k (e),
40k (eh) |
|  | PYTHIA(*) | 1M |  |
| Single top | PYTHIA | 1M(t,s) |  |

**Diff. top masses from 130 to 230 by 2.5 GeV step from 150 to 200, 5 GeV step outside this region (each: 200k): total 7.5M**
**Single top will be done at Karlsruhe**
**Top systematic samples (10 set: 4M): lower priority. **

## W/Z+njets(top bck, W/Z signal)

| ALPGEN /
MadGraph | e(gen) | mu | Tau(*) |
| --- | --- | --- | --- |
| W + N jets (N=0,1,2,3,4) | 300K | 300 | 300 |
| Z + N jets (N=0,1,2,3)** | 300 | 300 | 300 |
| Wccbar + N jets (N=0,1) | 300  | 300 | 300 |
| Wbbar+ N jets (N=0,1) | 300 | 300 | 300 |
| Wc+N jets (N=0,1,2,3) | 300 | 300 | 300 |
| Zccbar + N jets
(Z=0,1) | 300 | 300 | 300 |
| Zbbbar + N jets
(N=0,1) | 300 | 300 | 300 |

- *:Wbb/cc+1/2jets, W+3/4jets in e/mu:highest priority

## WW/WZ+njets(top bck, EW signal)

| ALPGEN+HERWIG | e(gen) | Mu | Tau |
| --- | --- | --- | --- |
| WW + N jets (N=0,1,2) | each 300k | each 300 | each 300 |
| WZ + N jets (N=0,1,2) | each 300 | each 300 | each 300 |
| ZZ+ N jets (N=0,1,2) | each 300  | each 300 | each 300 |

- No more e/mu/tau filter

## B-enriched QCD dijet sample for b-tagging with e/mu filter (5M: very low lepton filter efficiency, thus use 4.9.1MC hepg )

BB/CC + 0,1,2,3,4 Njets: each 300K (for top hadronic channel)

- BB/CC + 0,1,2,3,4 Njets: each 300K (for top hadronic channel)

- QCD samples
# Presentation: 712508

## Mailers Technical Advisory Committee (MTAC)August 6, 2003

**Automated **
**Package**
**Processing**
**System**
**(APPS)**

***Mailers Technical Advisory Committee (MTAC)******August 6, 2003***

**Notes:**
Good morning.  The next project that I would like to present is the purchase of 354 Automatic Tray Handling Systems (ATHS) for the Automated Flat Sorting Machine 100 (AFSM 100)

**  ****Purpose of APPS**
**  ****Video of APPS in operation**
**  ****Performance Specifications**
**  ****Enhancement to Presort labels**
**  ****Questions/Answers**

**Notes:**
Good morning.  The next project that I would like to present is the purchase of 354 Automatic Tray Handling Systems (ATHS) for the Automated Flat Sorting Machine 100 (AFSM 100)

**Purpose of APPS Deployment:**
** ****Replaces aging Small Parcel and Bundle Sorter (SPBS)**
**  ****Dramatically improved throughput**
**  ****Provides for OCR and BCR capability**
**  ****Handles a broader range of product**

**Notes:**
Good morning.  The next project that I would like to present is the purchase of 354 Automatic Tray Handling Systems (ATHS) for the Automated Flat Sorting Machine 100 (AFSM 100)

**Enhanced Presort Labels:**
**  ****Labels provided by USPS**
**  ****Label size: .75 inches wide by .5 inches tall**
**  ****Incorporates a barcode on presort label**
**  ****Barcoded labels for; Mixed, Firm, AADC/ADC, 5-digit and 3-digit **

**Notes:**
Good morning.  The next project that I would like to present is the purchase of 354 Automatic Tray Handling Systems (ATHS) for the Automated Flat Sorting Machine 100 (AFSM 100)

**Questions**
**And **
**Answers**

**Notes:**
Good morning.  The next project that I would like to present is the purchase of 354 Automatic Tray Handling Systems (ATHS) for the Automated Flat Sorting Machine 100 (AFSM 100)
# Presentation: 398084

## NOAA ACQUISITION PROCESS				                See Notes 1, 2, 3

**NOAA ACQUISITION PROCESS****	****	****	****	****                ****See Notes 1, 2, 3**

**START**

**ENTER**
**SOLICITATION**
**PHASE**

**Defining **
**Requirements**

**Acquisition **
**Planning**

**Potential**
**for OCI?**

**Develop OCI **
**Clause for RFP**

**NDA**
**OGE 450**

**Other than**
**Full and****Open**
**Competition?**

**Contract Types**

**Methods**
**Of **
**Procurement**

**Market Research**

**Acquisition Strategy**
**Acquisition Plan**
**Funding of Requirements**

**Procurement**
**Request (PR) **
**C.Request**

**Funding**
**IGCE**
**SOW/SOO/PWS**
**QASP**
**COR Nomination**
**SSP**
**AP**

**Justification &**
**Approval (J&A)**

***PLANNING***

***SOLICITATION***

- NO

- YES

- NO

- YES

**Non –DoC &**
** ****Non-NOAA contracts**
**GSA Federal Supply Schedules**
**NITES and NOAA IT**
**Consolidation**
**Unsolicited Proposals**

**Special**
**Considerations**

**Small Business**
**EIT/Section 508**
**Service Contract Act**
**Contract Security **
**Advisory & Assistance **
**Services**
**D&Fs**

**NOTES:**
**Note 1:  ****This flowchart provides a snapshot of the Planning Phase in the NOAA Acquisition Process. This is only a guide in defining when in the process **
**these tasks normally occur – the exact location in the contracting cycle for each item is somewhat flexible depending on program/contracting action **
**dynamics.  A detailed analysis of each event in the Planning Phase can be viewed by clicking on the appropriate event. **
**Note 2:  ****The** **Official Contracting Process is defined in the FAR, DOC Commerce Acquisition Manual, and the NOAA Acquisition Handbook.**
**Note 3:  ****Please refer to the governing directives for official guidance.**

**BEGIN / END**

**Program Office (See Note)**

**Supporting Information**

**Decision Node**

*NOTE:  These colors represent the dominant lead for each task.*

**LEGEND**

**NOAA AGO**
# Presentation: 847459

## Genomics Eddy RubinDecember 3, 2008

## DOE Joint Genome Mission

**DOE Joint Genome Mission**

**Supported by the DOE Office of Science, JGI unites the expertise of five national laboratories—Lawrence Berkeley, Lawrence Livermore, Los Alamos, Oak Ridge, and Pacific Northwest—along with the Hudson Alpha Institute for Biotechnology to advance genomics in support of the DOE missions related to clean energy generation and environmental characterization and cleanup. JGI is operated by the University of California for the U.S. Department of Energy.  The JGI Production Genomics Facility (PGF) is located in Walnut Creek, CA, equidistant between LBNL & LLNL.**

## The JGI Production Genomics Facility (PGF)

**The PGF’s workforce of ~240 is comprised of LBNL & LLNL employees (80%/20%).**

## JGI: A National User Facility

**World Class Science:**
**Advancing the scientific literature—over 48 papers in the journals *****Science***** and the *****Nature***** where JGI played a leadership role (first or senior authorship)**
**over the last three years, JGI has played a role and shared co-authorship in a total of 234 peer-reviewed publications  **
**Efficient and Productive Sequencing****: **
**Generating DNA sequence data (in October 2008 alone) of over 20 billion nucleotides, or the equivalent of over six human genomes).  **

## JGI as National User Facility II

**Broad/Diverse Impact through the Community Sequencing Program—over 1350 Users WW in 2008**

## Genomics: A Workplace of Many Disciplines:  Production, Computation, and Research

**@ the PGF:**
**Repetitive manual manipulation of sample plates to facilitate the Sanger sequencing process**
**Sample prep for next gen (454/Illumina) sequencers**
**Standard microbiological/molecular biology lab practice**
**Keyboard-intensive development of computational tools/data management/analysis**
**@ Building 84/74 (LBNL):**
**Standard molecular biology laboratory practices**
**Micromanipulation of mouse embryos for the creation of transgenic models**

## Integrated Safety Managment (ISM) Implementation

- JGI ISM Plan
- Weekly Senior Management Safety Briefings
- Safety presentations at All Hands Meetings
- Management Safety Area Walk Throughs
- Department heads participate in the Employee Safety Committee
- Department Heads assigned as responsible persons for CATS Issues

## JGI (Genomics) Practices Enhanced Safety

**Internal Ergonomic Program**
- Dedicated Staff Ergonomist
- Early Intervention/monitoring program
- Routine Case meetings
- Enhanced Remedy Interactive program
- On site LBNL Registered Nurse
**Custom Safety Training Courses**
- PGF-0010 JGI Safety Briefing
- PGF -0057 Laboratory Ergonomics
**Participation in Employees Led Safety**
- Employee Safety Committee
- JGI Emergency Response Team
- Safety Culture Team
- Ergonomics Working Group

**Ergonomics Working Group**

**Emergency Response Team**
# Presentation: 933836

## Uses of Recorded Data:

_**Uses of Recorded Data:**_
**SWISSAIR FLIGHT 111 **
***September 2, 1998***
***Peggy’s Cove, Nova Scotia***

## Example Wreckage from SWR111

**Example Wreckage from SWR111**

## Hangar in Halifax

**Hangar in Halifax**

## Reconstruction of Nose Section

**Reconstruction of Nose Section**

## Reconstruction of Nose Section

**Reconstruction of Nose Section**

## Sources of Recorded Data:

***Sources of Recorded Data:***

**Two radar sites**
**Air Traffic Control Recording**
**Flight Data Recorder**
**Cockpit Voice Recorder**
**Quick Access Recorder**
**Data Link Messages**
**Non Volatile Memory****	**

## Radar Data

**Radar**** ****Data**

**Transponder lost**
**Primary Returns only - no altitude**

## Air Traffic Control Recording:

- 1:14:18.0 UTC	SWR111:	Swissair one eleven heavy is declaring Pan Pan Pan. We have uh smoke in the cockpit, uh request (deviate), immediate return uh to a convenient place, I guess uh Boston ***.
- 1:14:33.2 UTC	QM:Swissair one eleven roger ... turn right proceed ...uh ... you say to Boston you want to go?
- 1:14:33.2 UTC	SWR111:I guess Boston ... we need first the weather so uh we start aright turn here. Swissair one one one Heavy.

## Flight Data Recorder

**Flight Data Recorder**

## Flight Data Recorder Solid State Memory Media

**Flight Data Recorder Solid State Memory Media**

## +250 parameters for +60 hours

**+****250 parameters for +60 hours**

## Cockpit Voice Recorder

**Cockpit Voice Recorder**

## Cockpit Voice Recorder Tape Media

**Cockpit Voice Recorder Tape Media**

## Preparing CVR Tape for Playback

**Preparing CVR Tape for Playback**

## Assorted Tape - Some of which is from the QAR

**Assorted Tape - Some of which is from the QAR**

## I’ll have the tape ready for playback in a few minutes!

**I’ll have the tape ready for playback in a few minutes!**

## Data Link Messages:

***Data Link Messages:***

** ****ACARS via VHF & SATCOM **** - recorded at AOC, ARINC & SITA**

## Non Volatile Memory:

***Non Volatile Memory:***

-  **F****ull**** A****uthority**** D****igital**** E****lectronic**** C****ontrol**

## Slide 19

## Slide 20

## Sequence of Events

**Sequence of Events**

## Future Direction

***Future Direction***

-  **Combined Recorders, Nose/Tail**
** ****2 hour CVRs**
** ****10 min. Independent power supply for CVR**
** ****Record CNS/ATM on-board**
** ****Elimination of Tape Recorders**
** ****Increased parameters**
** ****Introduction of crash protected video**
** ****Operator’s daily use of Flight Data (FOQA)**

## Future Direction?

***Future Direction?***

**Primitive Theme Park**

## Dennis R. Grossi
National Transportation Safety Board
Mike Poole
Transportation Safety Board Canada

*International Symposium on Transportation Recorders*

- Dennis R. Grossi
- National Transportation Safety Board
- Mike Poole
- Transportation Safety Board Canada

- Aviation Recordings
# Presentation: 489071

## Kerry Shearer

**Kerry Shearer**
- Sr. Communications & Marketing Specialist
- Sacramento Metropolitan Air Quality Management District

**Jamie Arno**
- Communications & Marketing Specialist
- Sacramento Metropolitan Air Quality Management District

## Funded with U.S. EPA OTAQ grant

**Funded with U.S. EPA OTAQ grant**
**Additional funding from U.S. EPA AirNow program**
**Project managed by Sacramento Metropolitan AQMD**
**Vendor partners:**
**JHME Advertising/Design/Public Relations**
**Sonoma Technology Inc. (STI)**

## Purpose: to link the nation’s air quality communicators in a way that provides:

- The support you need from experienced colleagues who can help you through communications challenges, solve problems, and share solutions.
- Instant access to great outreach items and projects so no one has to “recreate the wheel,” thereby increasing efficiency and cost-effectiveness.
- Increase your knowledge about air quality issues and best practices, improving your value to your agency.

## Instant access to great public outreach projects 

- Instant access to great public outreach projects
- Home page display of your agency’s air quality forecast
- Additional forecasts and real-time, “who’s-having-an-episode” data from AirNow
- The latest news releases from air agencies around the nation
- A forum to exchange questions, answers and ideas with colleagues
- A way to quickly locate your colleages at other air agencies
- A calendar displaying national events
- A page of useful links to the kind of resources communicators use

## Helps you quickly research outreach “challenges” and solutions

- Provides the inspiration for development of effective communications projects in your own area
- Helps you become a better-informed communicator, increasing your expertise and value to your employer
- Potentially improves the quality of air quality communications programs nationwide by providing you with access to the best approaches in public outreach

## The Air Quality Communicator’s Home Page

- Live Demonstration!

## View the site at:www.AirShare.info

**View the site at:****www.AirShare.info**
**Sign up as a registered member today at:**
**www.AirShare.info/signup**

## Slide 8