BEE-spoke-data/govdocs1-by-extension huggingface dataset:
# Presentation: 721676

## Department of Health and Human ServicesCenters for Disease Control and PreventionAgency for Toxic Substances and Disease Registry

***Department of Health and Human Services******Centers for Disease Control and Prevention******Agency for Toxic Substances and Disease Registry***

** ****C*****DC *****Portfolio Management**

- Public Health Practice Council Meeting
- December 8, 2006
- Portfolio Management Project

##   Establish Shared Leadership Model 
Two-way exchange with state and local public health partners and CDC leadership to enable effective decision-making  
  Align Goals and Resources
CDC resources effectively aligned with CDC/State goals
  Improve CDC Business Practices
Reduce unnecessary administrative burden and streamline business processes associated with CDC grants

**Two-way exchange with state and local public health partners and CDC leadership to enable effective decision-making  **
**  ****Align Goals and Resources**
**CDC resources effectively aligned with CDC/State goals**
**  ****Improve CDC Business Practices**
**Reduce unnecessary administrative burden and streamline business processes associated with CDC grants**

**Our Goals **

##   SMOs in the States:
Senior-level coordinators placed in the SHOs Office
Perform annual assessment of CDC state-wide investments and collect/manage state/city observations regarding CDC business/program activities 
  PMP Atlanta
Atlanta based connectivity with CDC leadership and program staff
Coordinate PMP across all states with SMOs
Maximize information dissemination

- Senior-level coordinators placed in the SHOs Office
- Perform annual assessment of CDC state-wide investments and collect/manage state/city observations regarding CDC business/program activities
**  ****PMP Atlanta**
- Atlanta based connectivity with CDC leadership and program staff
- Coordinate PMP across all states with SMOs
- Maximize information dissemination

**Our Role**

## CDC’s Extramural Investments FY 2005PMP Sites (Non-Research* Grants)

- Total in PMP States:
-   $4,452,165,416 (2,428 grants*)*
*  *253 field staff (43% of all field staff in the U.S.)

*******An additional $164,284,074 is awarded to PMP states in research grants
- And $32,015,338 of $115,278,752 total in PHHS Prevent Block Grant

***Note: SMOs also now in place in NC, CO, LA***
# Presentation: 276410

## DRI Photoacoustic Instrument 

- Pat Arnott, DRI, pat@dri.edu.

- PA in operation, sampling from a dyno.  Consists of laptop, tan colored box where instrument is housed, and black 19” equipment rack for electronics.
- Aircraft version will be smaller and able to fit in 19” rack.

## Status

- Ground based unit ready.  May have 2 wavelength operation ready for IOP (532 nm, 675 nm and or 1047 nm).
- Trying to reduce the size of instrument for aircraft use.  Parts are being machined for the reduced size unit.  Will probably use 523 nm or 675 nm laser.  675 nm would go well with NASA CRD.
- Could use existing unit if necessary for aircraft use.

## Summary of Current SGP Measurement by NOAA:  What to expect aloft and at the ground (purple).

- Boxes are 25%, 50%, and 75% values, whisker ends are 5% and 95%.

## Interesting reduction of Single Scatter Albedo with height from the NOAA CMDL data set (Pat Sheridan)

- Altitude in meters, Extinction is on left in Mm-1, and single scatter albedo on the right.
- AOS ground based values are in purple

## Estimated Leg lengths as a function of altitude for good Photoacoustic Data

## Estimated Leg Lengths: The numbers

- Median Babs values aloft from NOAA were used to estimate the time necessary to achieve good photoacoustic measurements at different altitudes.  Clean or dirty days could change the picture dramatically.  These are integration times for a SINGLE good measurement.  Decide the number of measurements needed at each level, and multiply the times by this value.  These estimates are based on experience, should be realistic.

## ISSUES

- RH conditioning?  Are we going to take the aerosol at whatever RH appears, or measure the RH in each instrument? (scattering and extinction measurements especially need thought).  Filter-based light absorption instruments should be presented with DRY aerosol (RH < 30% ideally).
- Leg durations need to be much longer as the altitude increases to get good data, likely from all aerosol instruments.
# Presentation: 192945

## BLIP operations 2-3-09

**Status – running at ~118 MeV **
**Beam pulse 440μs, 32mA, 6.67Hz, less polarized proton pulses**
**Careful integration of beam current transformers in Linac and BLIP now gives good agreement with radiochemical determination (65, 67.6, 64.3+/-5% μA respectively). Unfortunately this is lower than previously estimated**
**Beam intensity profile was measured by phosphor imaging system.  Shows tighter focus**
**Ratio of activation of  small and large diameter foils shows all beam within target **
**Plans**
**Beam current increase by changing polarized proton pulse sequence in order to increase BLIP share of Linac output**
**Replace current transformer cable with low resistance cable**
**Build new power supply for LEBT buncher**

## Measured BLIP beam profile (x&y in mm, z is intensity arbitary scale)

## BLIP Integrated current
# Presentation: 692505

## RHIC Spin Flipper

- RHIC Spin Collaboration Meeting, August 18, 2003
- Mei Bai, BNL, Upton, NY 11973

## Spin flipping during RHIC pp 2003 in Blue ring

| Fill # | Drive amp. | d | t [turn] | s | Pb0 | Pb1 | Pb2 | Py0 | Py1 |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 3799 | 0.26 | 0.47-0.49 | 2x106 | 0.48 | 0.22 | 0.20 | -0.054 | 0.24 | 0.068 |
| 3801 | 0.3 | 0.47-0,49 | 2x106 | 0.48 | 0.234 | 0.224 | 0.0223 | 0.23 | 0.065 |
| 3803 | 0.8 | 0.46-0.48 | 2x106 | 0.47 | 0.18 | -0.049 | N/A | 0.21 | 0.23 |
| 3811 | 0.4 | 0.465-0.485 | 2x106 | 0.475 | 0.076 | 0.0 | N/A | N/A | N/A |

## What can we learn?

- Spin tune in yellow is not 0.5
- Need time to calibrate snake setting – spin tune measurement
- Simulation is needed to study the spin tune spread effect
- Source for spin tune spread
- Beam emittance: ~ 0.009(15, 100GeV)
- Higher order effects: needs tracking to find out
- The last two spin flipping attempts with stronger spin flipper strength caused the radiation level around phobos exceeded the threshold limit which pulled the permit.
- No aperture at the end of store to do the spin flip study.
- Prefer to have dedicated time to commission the spin flipper

## Spin flipper commissioning plan 

-  spin tune measurement
-    method: measure the polarization vs. different spin flipper frequency
-    - at injection: 8hr
-  two sets of 10 datapoints, each data point is taken with new filled
-         bunches(55, filling time=5min) and each datapoint takes 5min
-         to measure.
-    - at store: 16hr
-  two sets of 10 datapoints. the same assumption as the injection
-   measurements plus the ramping timing and new stores if necessary.
- The amount of time for this measurement can be greatly reduced if
- one can measure the turn-by-turn spin precession.

## Spin flipper commissioning plan

-  spin flipping
-    Three sets of measurements:
-    a) measure the spin flipping efficiency vs. flipper strength. The flipper
-        frequency sweep range as well as the spin tune remain constant.
-    b) measure the spin flipping efficiency vs. flipper frequency sweep range
-        with fixed flipper strength as well as the spin tune.
-    c) repeat b) with different spin tune.
-    with the current snake power supplies, we are able to move the spin tune
-    to 0.45 the outer current of one snake should be 94Amps and the inner
-    current should be 294.54Amps. The nominal current setting for the snake
-    is (inner,outer)=(326.23,100). It takes about  2 minutes to ramp the snake
-    current from 326.23 to 294.54.

## Spin flipper commissioning plan

- Prefer to do the measurements at injection first. The estimate for
- the three measurements is 16hrs. To do a) and b) at store, one
- may need about 20 stores (assume 10 data points per set). Assume
- 50 mins per store including the measurement, total 16 hrs will be needed.

## Spin tune at store
# Presentation: 404455

## Update from the Office of Vaccines Research and Review, CBER/FDA

- NVAC Meeting
- Washington, D.C.
- February 4-5, 2003

## New Approvals since October 2002 NVAC Meeting

- FDA licensed a new combination vaccine containing DTaP, hepatitis B, and IPV in 12/02
- Marketed as PediarixTM by GSK
- DTaP and hepatitis B components from GSK previously licensed, but not the IPV
- Indicated for active immunization against diphtheria, tetanus, pertussis, hepatitis B, and polio types 1-3 in infants born to HB-sAg negative mothers

## New Approvals since October 2002  (cont.)

- PediarixTM recommended for administration at 2, 4, and 6 months of age
- Induced immune responses comparable to those induced by separately administered licensed vaccines
- Most frequent adverse reactions:  injection site reactions, fever, and fussiness
- Fever occurred more frequently after administration of PediarixTM, compared with separately administered vaccines

## New Approvals since October 2002  (cont.) 

- October 2002:  supplement to Wyeth’s BLA for Dryvax smallpox vaccine approved
- Provides for 100-dose kit with new source of diluent and needles
- January 2003:  supplement to Aventis Pasteur Inc.’s BLA for DT vaccine approved
- Provides for trace-thimerosal formulation

## VRBPAC Update

- BLA for FluMist, MedImmune’s live, influenza virus vaccine discussed at Dec. 2002 VRBPAC
- Majority of the committee voted that the data were adequate to support safety and effectiveness in healthy individuals 5-49 years of age
- Review ongoing
- Next VRBPAC meeting Feb. 20, 2003 to discuss the influenza virus strains to be included in 2003-2004 vaccine formulation
# Presentation: 230202

## Healthy Healing

- Biologist Luisa Ann DiPietro:       *Reducing Scarring and Speeding Healing*

## Luisa DiPietro Optimizes Healing

*Dentist and biologist DiPietro works to change the way we view healing.*

*Healing*
- Is a regenerative series of events
- Involves >12 cell types and >100 molecules
- Can go awry

*Question:*
-   Do all types of tissue heal equally well?

- Photo: Bill Wiegand

## Answer: No

**Different types of tissue heal better than others.**

- Skin tissue is more likely to scar than are mucous membranes
- Slippery tissues inside the nose, ears, mouth, and other body cavities heal faster than skin tissue
- Diseased tissue in arteries may not completely heal
- Wounds in people with some diseases may heal more slowly than those of healthy people

## Stages of Healing

## Inflammation in Cells

- Neutrophils are the first cells to respond to injury
- Macrophages clean up debris
- Mast cells induce swelling, warmth, and redness
- All 3 types of cells summon more immune system cells

- Wound cells

- Photo: Copyright Dennis Kunkel Microscopy, Inc.

## Angiogenesis

- New vessels grow and cover wound
- New vessels bring oxygen and nutrients to wound
- Proteins grab the edges of wound and close it, forming a protective mesh
- Excess new vessels die off

- Scar

## Too Much of a Good Thing?

- Excess inflammation can damage healthy, neighboring tissues
- Excess inflammation can be life-threatening
- Excess angiogenesis can worsen scarring

**How does this happen?**

**When is inflammation potentially dangerous?**

**In what types of human cells does this NOT occur?**

## DiPietro’s Gnawing Problem

- As a dentist, DiPietro knew that severe scarring is rare in tissue with mucous membranes, such as mouth tissue
- As a biological researcher, DiPietro wants to know why the same is not true of other types of tissue, like skin

## Knowledge By Comparison

**Approach #1****:** Compare how lab-grown, human skin and mouth cells respond to injury
**Approach #2:** Compare healing process of injured skin and tongues in mice

*In vitro* experiment

*In vivo* animal experiment

- DiPietro’s Approaches to Better Understand Healing

## Many Unanswered Questions

- What causes scarring?
- Why does your mouth scar so much less severely than your skin?
- Can we learn from these differences?

## Research Applications

- Can you think of a new way to prevent scarring?
# Presentation: 011857

## Draft NRPF Diagram

- Vision

- Rural communities across Canada that are socially and economically vibrant, where citizens are fully engaged in participating in and benefiting from local and national prosperity.

- Strategic Objectives

- Policy areas that affect community sustainability and viability

**Demographic  Adaptation**

- Intermediate Result - Citizens have access to economic and social opportunities

**Draft NRPF Diagram**

**Supporting Community Capacity Building**

**Collaboration Across and Amongst Governments**

**Renewal of the Economic & Social Base**

**Engaged Population and Institutions**

**Smart Approaches to Infrastructure**

**Environmental Stewardship**

**Sustainable Livelihoods **

- Strategic
- Investments

- Risk
- Management

- Information
- Management

- Risk
- Management

- Risk
- Management

- Risk
- Management

- Risk
- Management

- Principles

- Feed
- Back

- Community  Actions

- Feed
- Back

- Values

- Government Actions

- Municipality Actions

## The framework will respond to community development challenges

*The framework will respond to community development challenges*

**Notes:**
Six Principles agreed to are the essential principles to address the challenges of community-centered development.

They are:

The community is the cornerstone of rural development,

Collaboration across and amongst governments is essential to achieve a vision of rural Canada and to provide clear accountability,

A flexible governmental approach is required to address rural diversity,

A multifaceted integrated approach is necessary to realize a community’s potential,

Investment in local leadership fosters a culture of citizen engagement, and that

Business and entrepreneurship are essential components of building strong rural communities.

## The framework is being developed to establish a new approach to rural issues   

- Sector-driven

- Vertical

- Compartmentalized

- Accessible

- Community-driven

- Reactive:
- crisis-driven

- Horizontal

- Proactive:
- future-focused

_**Goals**_

_**Information**_

_**Decision-making**_

_**Strategic investments**_

**             *****From                                             To***

**Notes:**
The framework is intended to help move us towards a new way of working.

To help move our efforts in rural Canada away from “stove-pipes” or to use a rural metaphor, “silos” where we keep to our own areas of sector expertise, for example agriculture, forests or transportation –  to work across these areas towards common goals. 

These goals should consider a community perspective.

Information collected by governments and held by departments and agencies should be made available to communities.

 A pro-active future-focused approach to priority-setting and decision-making should help to reduce the number and severity of crises affecting rural Canada.

And existing and future government investments should be better coordinated across departments and agencies.
# Presentation: 528532

## Best Practices

- Working Efficiently and Accurately

- Rod Sams

## Best practices DIY toolbox 

- Use as needed
- Good for a tune up
- Good for an overhaul

## Resources

- Centralized location for tools
- Forms & Processes that work

## Policy tools

- Samples
- Policy checklist
- Policy receipt form

## Pre-employment

- Previous employer record check
- Ask applicant – ever test positive or refuse to take a pre-employment test
- Send for pre-employment test

## New hire

- Negative drug test
- Random pool
- Policy receipt
- Training – 60 minute drug

## Random testing tools

- Scheduling random tests
- Results tracking
- Testing pool(s)
- Off for 90-days
- Out of random pool
- Still in random pool

## Collection site

- CCF overlay
- Report for collection
- Monitor site

## Post-accident

- Use post-accident card
- Be in the loop

## DIY Audit pre-employment

- Pre-employment
- Evidence of 60 minute drug training
- Receipt of company D&A policy
- Requests from former DOT covered employers
- Written request from employee for above

## DIY Audit random testing

- Random tests
- Date of selection
- Test notification form (if used)
- Date and time of notification
- Pool maintenance
- Reasonably spread throughout day
- Predictable?

## DIY Audit post-accident

- Post-accident
- Thresholds met?
- Correct test type done
- Date and time of accident

## DIY Audit reasonable suspicion

- Documentation of training
- Supervisors
- Employees
- Reasonable suspicion form

## DIY Audit RTD and follow up

- SAP written report
- Follow up testing plan
- Plan followed?
- Minimal testing met?
# Presentation: 856670

## WNV Avian Surveillance and Its Use in Predicting Human Risk

- Stephen C. Guptill
- U.S. Geological Survey

## Acknowledgements

- Division of Vector-Borne Infectious Diseases, CDC
- New Jersey Department of Health
- USGS Colleagues
- Susan Price, Lesley Milheim, Dave Norman, Lee De Cola, Bob McLean

## WNV National Surveillance Program

**Notes:**
In 2001 the avian surveillance activities detected 7336 WNV positive birds; located in 328 counties; in 27 states plus the District of Columbia.

## Surveillance Mapping on the Web

**Notes:**
USGS and CDC continued their collaborative efforts to post surveillance results on the World Wide Web.  CDC provides surveillance data to USGS.  USGS creates status maps and graphs on a weekly basis. In 2001, data was posted for 30 weeks. Over 2,600 separate maps were created and over 10,800 web pages were created or updated during this time period.

## Geographic Spread of WNV 

**Notes:**
The first WNV positive bird in a county was reported in Week 15.
The last report of an initial WNV positive bird in a county was reported in Week 49.
The mean date for the initial county report of a WNV positive bird was Week 34.

## Slide 6

**Notes:**
WNV exhibited both expansion and contraction from the area covered in 2000. 
76 counties plus the District of Columbia reported WNV positive birds in both 2000 and 2001.
51 counties (40 in New York) reported WNV positive birds only in 2000.
251 counties were new to report WNV in 2001.

## Avian Flyways - Pathways of West Nile Virus?

**Notes:**
One hypothesis on the mechanism for the spread of WNV is that it is being spread via the migration of infected passerine birds.
# Presentation: 915325

## Endocrinologic and Metabolic Drugs Advisory Committee July 1-2, 2008

## Timeline of Anti-diabetic Therapies and Clinical CV Trials

**1920**
**Banting/Best**
**Insulin isolated from**
**dogs**

**2000-present**
**GLP analogues**
**Amylin analogues**
**DPPIV-inhibitors**

**1980**
**Rec Human **
**insulin**

**1990**
**Insulin **
**Analogs**

**1940**
**SU**

**1950**
**Biguanide**

**1990-2000**
**Metformin**
**Alpha-glucosidase inhibitors**
**Thiazolidinediones**
**Glinides**

**UKPDS**

**ACCORD**
**ADVANCE**
**BARI 2D**
**HEART 2D**
**VADT**
**PROactive**
**RECORD**
**ORIGIN **
**NAVIGATOR**
**ACE**
**STOP-NIDDM**
**DREAM**

**UGDP**

**1970**

**DCCT**

## AC Question

**It should be assumed that an anti-diabetic therapy with a concerning CV safety signal during Phase 2/3 development will be required to conduct a long-term cardiovascular trial.  For those drugs or biologics without such a signal, should there be a requirement to conduct a long-term cardiovascular trial? (vote yes/no requested)**
**If “yes”, please discuss when such a study should be conducted:**
**Pre-approval**
**Post-approval.  If a long-term CV trial is required post-approval, please discuss whether this study should be ongoing at the time of approval (i.e., trial already initiated at time of approval). **

## As no currently marketed anti-diabetic therapy has established evidence of macrovascular benefit and most have not been tested for lack of cardiovascular harm, please discuss how any suggestion for a requirement for a long-term CV trial in question 3 above for drugs or biologics seeking an indication for the treatment of type 2 diabetes mellitus should be applied to existing anti-diabetic therapies.
# Presentation: 015735

## Airport and Survival Issues

- Bombardier CRJ-200
- Pinnacle Airlines
- Traverse City, Michigan
- April 12, 2007

## Traverse City Airport (TVC) 

- Part 139 certificated airport
- Snow and ice control plan
- Runway contamination removal
- Runway surface condition reporting

## Snow Removal Activities

- Before accident flight arrived
- Runway plowed full length and width
- Field condition report issued
- Increasing snowfall
- 10 minutes later - braking action “nil”

## Airport Condition Report Options

- TVC operations website (real time)
- Notice to airmen
- Direct communications with pilots on common traffic advisory frequency (CTAF)

## Airfield Communications 

- 12:25 a.m. – Initial contact with TVC operations personnel
- 12:27 a.m. – Report of “thin wet snow over patchy thin ice” received
-  First runway contamination indication
- 12:38 a.m. – Braking action “nil” report
- Not heard by pilots
- 12:41 a.m. – Braking action “probably nil” report
- Captain requested confirmation
- TVC airport operations did not confirm

## FAA Advisory Material 

- Advisory Circular
- Triggers for snow removal: snow depth
- No triggers based on friction assessments
- SAFO 06012
- Operations in “nil” conditions unsafe
- No FAA restrictions on airports regarding friction

## Accident Detection and Location

- Aircraft rescue and firefighting crew unsure of accident location
- Forward-looking infrared device did not help
- Little Rock, Arkansas accident
- Recommendation to evaluate crash detection and location systems
-  Classified “Open – Unacceptable Response”

## Slide 8
# Presentation: 863606

## Beams Week in Review

- Improved Performance
- Run IIa record luminosity
- Good reliability

- All Experimenters Meeting

## Initial Luminosity

- All Experimenters Meeting

## Peak Luminosity

- All Experimenters Meeting

## Integrated Luminosity

- All Experimenters Meeting

## Why Improved Luminosity?

- Store 1486 – 1 July

- Store 1499 – 5 July

*Proton Lifetime at 150 GeV*

- All Experimenters Meeting

## Why Improved Luminosity?

*Reduced Transverse Emittances*
*as a function Stack Size – more Pbars to Tevatron*

- All Experimenters Meeting

## Store Summary

| Store # | Initial Luminosity | Duration | Termination | comments |
| --- | --- | --- | --- | --- |
| 1486 | 6.67 E30 | 21 hours | intentional |  |
| 1493 | 14.77 E30 | 16.2 hours | intentional | Post-studies, A0 vertical angle bump |
| 1494 | 16.64 E30 | 18.75 hours | D3 dump failure |  |
| 1499 | 21.22 E30 | 18.87 hours | intentional | Record pbars to low  |
| 1501 | 19.66 E30 | 15.58 hours | intentional |  |
| 1507 | 18.39 E30 | 16+ hours | in progress | Improved proton losses up ramp |

- All Experimenters Meeting

## Protons to Collision

- All Experimenters Meeting

## Pbars to Collision

- All Experimenters Meeting

## Tevatron Summary

- Studies
- A0 vertical angle change (-0.05 mrad)
- Coupling at 150 GeV and helix
- Tevatron Electron Lens
- ‘dancing’ Bunches
- Bunch-by-bunch longitudinal damper

- All Experimenters Meeting

## Pbar Summary

- Stacking sluggish
- PMAG failure
- Studies
- Cut short by PMAG failure
- Debuncher tunes
- P2 trim strength re-calibration
- Core cooling equalizers
- Design complete
- Install this week?

- All Experimenters Meeting

## MI Summary

- Low Emittance Proton Coalescing Studies, 8 GeV coalescing
- Flying Wire Studies
- MI8 Line/MI lattice matching studies.

- All Experimenters Meeting

## Schedule for this Week

- Five shifts of Tevatron studies in two parts
- Proton lifetime vs. F0 Lambertson position
- P1 and A1 line lattice measurements
- Tune drift
- 36 X 12: pbar lifetime vs. proton intensity
- Longitudinal damper
- Operational studies as needed

- All Experimenters Meeting

## Schedule for this Week

**Pbar**
- Beam line lattice
- A:EKIK flattop
- Stacking/Accumulator cooling tune up
- Install equalizers this week?
- Support Tevatron studies
**MI**
- Support and participate in other machine studies
- 8 GeV coalescing
- MI8 Mikado
**Recycler**
- Transfer line
- Injection losses
- Pbars next week?

- All Experimenters Meeting

## Schedule for this Week

- All Experimenters Meeting

## Increased Luminosity?

**Pbar cooling equalizers**
**Shot Lattice**
**Increased Stacks**
**Reduced Pbar Momentum spread**
**Reduce beam loss in Tevatron**
**More Protons in Tevatron**

- All Experimenters Meeting
# Presentation: 331476

## ResubmittingElectronic Data Reports

- 				                 **NOx SIP Call Workshop**
- 			     	                 June 10, 2004
- 				                 Martin W. Husk, EPA

## Why Resubmit? 

- You resubmit to address an error in the electronic data report (EDR) feedback.
- You resubmit to address an error identified by the electronic audit process.
- You find an issue with your data not identified in the EDR feedback or electronic audit process.

## How to Resubmit

- During the submission period
- Use SecuRemote and ETS-FTP to submit your EDR to the EPA mainframe
- Outside of the submission period
- Contact your ETS assigned analyst to let them know you need to resubmit
- Access to the EPA mainframe will be opened
- Use SecuRemote and ETS-FTP to submit your EDR to the EPA mainframe

## How to Resubmit (cont’d)

- After Year-End Compliance
- Contact your ETS assigned analyst to let them know you need to resubmit
- Email your files to your ETS assigned analyst
- The files will be processed and feedback returned by Email

## EPA Assigned Analysts

- Region 3 - Ujjval Shukla				(202) 343-9196       shukla.ujjval@epa.gov
- Region 4 - Kevin Tran					(202) 343-9074      tran.kevin@epa.gov
- Region 5							Cindy Walke   (202) 343-9194   walke.cynthia@epa.gov  Louis Nichols  (202) 343-9008  nichols.louis@epa.gov

## Points to Remember

- You may always resubmit to fix data
- When in doubt, call CAMD
- EPA Accepted Value in the EDR feedback is used for year-end compliance
- Update your passwords
# Presentation: 804311

## D0 Status: 03/18-03/25

- Week integrated luminosity
- 1.6pb-1 delivered
- 1.2pb-1  utilized (75%)
- Data collection
- global data collections most of the time
- full detector in readout
- physics trigger menu: v5.00
- major sources of downtime last week
- master clock problems
- 4 hours of beam time on Friday
- 1 hour of beam time on Sunday
- readout crates problems: muon and CFT
- D0 farms operation
- keeping pace with data collected by the detector
- reconstructing ~4mln events per day
- recording ~2mln events per day

## Tevatron Backgrounds

- Tevatron backgrounds
- last week had low/stable p and pbar halos
- below ~3kHz for pbar
- below ~40kHz for p
- no substantial effect on D0 operations
- getting silicon rad. protection alarms on average every other store
- step 13
- more about D0 silicon irradiation in Ron Lipton talk

## D0 Detector Status

- Luminosity detector
- stable operation
- estimated measurement accuracy is 10%
- Silicon detector
- low voltage supplies status
- more then one month of no trips operation
- full silicon detector in readout
- working on reduction of HV turn ON/OFF time to increase operating efficiency
- Fiber tracker
- installation and upgrade of AFE boards continue
- ~130 AFE boards are installed on platform
- ~100 of installed AFEs are been modified for VLPC temperature stability control
- stable operation during data taking with some time devoted to CFT commissioning

## D0 Status

- Calorimeter
- stable operation
- Muon system
- no serious problems
- replacement of failed electronics boards
- typically over 98% of the system is in readout
- beam based forward muon aging/occupancy studies results
- system could operate well above luminosity 2.1032 and integrated luminosity of 15fb-1
- Forward Proton Detector
- routine pots insertion during stores
- Plans for this week
- currently no access requests
- global runs during store later today
- cosmic/halo running, master clock and other studies during TeV studies Tuesday-Wednesday
- global running during the rest of the week
- physics trigger list version 5.00
- full detector in readout
- rate to tape ~30Hz

## Summer 2002 Shutdown

- We are putting together detailed list of D0 summer shutdown activities
- at this moment most time/labor consuming job is modification of silicon power supplies
- estimate 4 weeks plus detector opening/closing and survey
- 2 weeks shutdown late May - early June has disadvantages for D0
- will be in stable data collection mode for summer conferences
- peak time for fiber tracker trigger commissioning
- D0 preferences for summer 2002 shutdown
- single shutdown
- 6 weeks shutdown beginning between middle of July (after July 12th) and middle of August
# Presentation: 037885

- Kaiki Taro Inoue
- (Kinki Univ.)

- Local voids as the origin of the large-angle
-                   CMB anomalies

- Joseph Silk
- (Oxford Univ.)

- astro-ph/0602478

- To appear in ApJ

- Outline

- Large-angle CMB anomalies

- Anisotropy for a dust-filled void

- Summary

- Origin of anomalies

- Discussion&Prospects

-   WMAP 3rd year data

- Angular power

-  Large-angle anomalies

- Quadrupole

- Bump?

##  North-South Asymmetry  

- Small power

- Large power

- Eriksen et al. ’03

- “South”

- “North”

-  North-South Asymmetry

- North pole:(*l,b*oo

## North-South asymmetry

- “Southern hemisphere”

- Eriksen et al.
- ’03, ’04

- North pole:(*l,b*oo

- “Northern hemisphere”

## Axis of evil?

-                                (Tegmark, et al, ’03)

*l*=2

*l*=3

- Axis of evil?

## 3σcold spot?

- 3σcold spot?

- Vielva et al.

## Candidates of the origin 

- Candidates of the origin

- No satisfactory solution!

- (Luminet et al. ’03)

- (Jaffe et al. ’05)

## Mass scale & strucutre?

- Local Inhomogeneities?

**Mass scale ****& ****strucutre****?**

- No satisfactory solution!

## Anisotropy for a dust-filled void

- Assumption: dust-filled sphere+EdS+thin wall

- void

- **

*r**v*

- (*r,t* )

- (*r’,t’*)

- r<<H-1

*t*1

*t*2

*ρ*

*ρ****ρ*

**Generalization of Thompson & Vishniac,’87**

## background

- inner region

- Matching condition

- Expansion by a small parameter *r **R/t*<<1

- “Double Lorentz transformations”

- Expansion of
- compensated void

## 2nd order Rees-Sciama effect 

- *for* **<<1

- T/T~10-5, **          *r*~300 *h*-1*  *Mpc

- 2187

- T/T ~

**2(*r/t*2* *)3cos **(3+24 cos2 *** *)**

- 4

- 2nd order Rees-Sciama effect

**Temperature anisotropy**
**   ****(EdS background)**

##  r   (h-1 Mpc)

**2(*r/t*2* *)3

* **r   *(*h*-1 Mpc)

## Void effect on CMB

- Hot

- Cold

- apparent void radius

- physical void radius

## Effect of non-linear parameters 

- Model:* *EdS,* r**v**=*340 *h*-1* *Mpc,   **=-0.3

## A pair of voids? 

- Observed

- Pair of identical voids

*l*=2

*l*=3

*l*=2+3

- (*l,b*oo

- Model A

- Model B

## 2nd order effect 

- *for* ***M *<<1

- T/T~10-5, ***M*          *r*~200 *h*-1*  *Mpc

- T/T ~

-  **Temperature anisotropy**
**(flat-******** background ************=0.7****)**

- 2nd order effect

- 1st order effect

- Coherent effect **(Tomita ’05)**

- (Preliminary)

## Summary

-   We studied the effect of the thin-wall spherical
-     dust-filled void on CMB (EdS & flat-)

- A pair of voids with a radius *r*~200 *h*-1* *Mpc
**a density contrast ***M***~-0.3? (5 )

-  Redshift for inner part, blueshift for outer part

- A void at z~1 gives a cold spot?

- NS asymmetry due to asymmetry in distribution?

- Coherent 2nd order effect contribution
-     ~20% for  a void with ***M***~-0.3 (LCDM)
# Presentation: 489241

## National Transportation Safety BoardForum on Driver EducationOctober 29, 2003

**Presentation By**
**Debbie Cottonware**
**American Driver and Traffic Safety Education Association**** **
**2003-TEACHER OF THE YEAR**

## Car Crashes...

- #1 killer of teenagers
- Nearly 7000 teens die each year
- Twice the number of those killed on 9/11

- We went to war over 9/11!
- What are we dong about teens dying in cars?

## Driver Education

## Must become a part of Basic Education

- A privilege
- But an essential one

- Social task
- Interact appropriately
- Safely

## So...

- What is Traffic Safety Education all about???
- QUALITY programs that
- Work toward lowering high risk behaviors
- And promote GOOD habit development

## Debbie Cottonware

- ADTSEA Teacher of the Year
- Teacher
- 5th grade  currently with Havre Public Schools
- Traffic Safety Coordinator/Instructor
- 18 years, Onalaska School District in Washington
- Trainer of Teachers
- Central Washington University
- Montana State University-Northern

## Misperception

- The public perception
- What we really do...

- VS

## The challenges we face...

- Misperception

## 4 Sample questions

- What color is a yield sign?
- What is the correct hand position on the steering wheel?
- What is a reference point?
- If the ABS light comes on while driving, what does it mean?

## #1 

**YIELD**

## #2

- 9 AND 3

## or

- Why?

*AIR BAGS!*

- 8 AND 4

## #3

- From the driver’s seat,** see some part of the vehicle**, as it relates **to some part of the roadway**, to show where the vehicle is actually located on the roadway.

## Slide 15

## Right Side limitation

## #4

- ABS- Anti lock braking system
- 		Can vary from
- 			make to make
- 			model to model

## The challenges we face...

- Time

- Montana
- 60 hours, to include 6 BTW
- Washington
- 30 hours and 4 BTW

- Learning takes place when behavior is changed
- Perfect practice makes perfect skills
- Doing things right, doing the right things

##    You 	   have		   heard			   this 				   before...

## The challenges we face...

- Lack of consistent standards for content and delivery of the program

## National standard developed
Implemented
Expected
of ALL

Traffic Safety Education as a Comprehensive  K-12 curriculum

A part of Basic Education

- Implemented
- Expected
- of _***ALL***_
- Traffic Safety Education as a_*** Comprehensive***_  K-12 curriculum
- A part of Basic Education

## The challenges we face...

- Misperception
- Time
- Lack of consistent standards for content and delivery of the program
- Lack of monitoring and meaningful evaluation

- Mentors
- Evaluation
- Professional development
- Adequate funding

- Public education does work
- Parents trust the teachers
- And the schools

## Stakeholders

- Public health organizations
- Insurance companies
- Law enforcement agencies
- Judicial bodies
- Highway administrations
- Educational agencies

- Mobility
- Safety

- vs

## Slide 29

## Teachers do what they do because 

- is good for kids.
- Driver Education teachers are no
- different.

## Thank you for your time today.
# Presentation: 900140

## Studies of Global Confinement- A Progress Report

- Michael Bell

- Database of confinement data from this run
- Based on magnetic and MPTS data
- Supplement with CHERS data when it becomes available
- Observations on data consistency

## Compiled Database for Studying Trends in Global Energy Confinement

- 1802 shots from 2004 with data sampled at time of peak electron stored energy calculated from MPTS and EFIT01 data
- LOCUS (ISAM) format in BELL$:[NSTX.04]TSAN.DBC

## Using EFIT01 Mapping, Integration Inside Magnetic Axis Yields Higher We, Ne

- Use in/out average for confinement studies

## Example Showing Tendency for Inside Mapping of MPTS pe(R) to Exceed Outside

- Less pronounced for MPTS ne(R) data
- Effect of intrinsically asymmetric density profiles?

## Some Systematic Difference Between EFIT01 & EFIT02 in WMHD

- Would affect scalings derived from EFIT data

## Now Adding More Accurate Calculation of Ohmic Power and Including dW/dt Term in E

- Average dW/dt over 20ms prior to maximum We
- POH includes Vres correction for changing *toroidal* flux

## Electrons Comprise Small Fraction of Total Stored Energy, Even with HHFW Heating

- With NBI, We/WMHD increases at highest WMHD because density is higher and unthermalized NB ion component decreases

## Electron Energy Fraction is Anomalously Low in Most OH Helium Plasmas

- Expect Te > Ti, ne ~ 2*ni at high density so We/Wtot > 2/3
- Higher points from just before MPTS window “event”

## 2004 Data Provides Adequate Ranges for Dominant Parameter Scaling Studies

- Need to distinguish L- and H- mode shots
- Not always possible from easily quantifiable criteria
- HHFW cases complicated by variations in antenna phasing
- LOCUS expressions defined to select standard phasings

## Peak to Volume-Average Electron Density Can Distinguish H- & L- Modes at Extremes

- L-mode

- H-mode

## Scaling of Stored Energy With HHFW Power

- Data for HHFW “heating” phasings
- Balanced 14m-1 and 7m-1
- H- & L- modes intermingled

## Summary

- Made a start on a comprehensive database for confinement studies
- Also generally useful for identifying shots meeting specific criteria
- Identified some issues with data consistency which need to be resolved before we draw sweeping conclusions
- Validate EFIT calculation of WMHD particularly at lower values
- Use MSE to improve q profile
- TRANSP calculation of total pressure profile shape
# Presentation: 539362

## Chemical World

-  Toxicologist Serrine Lau:
* *Investigating Molecular Crime Scenes

## Serrine Lau is a toxin detective

*Lau investigates how our bodies interact with poisonous chemicals.*

- Toxicologists study how
- People process chemicals
- DNA interacts with chemicals
- Genetic differences affect risk of disease from chemical exposure

*Question: *
- Which toxic chemical is in cigarette smoke?

## Answer: Polyphenol

- Found in cigarette smoke, car exhaust, photo developing solutions, some cosmetic depigmentation creams

- _Hydroquinone _is a polyphenol that yields toxic byproducts in the body.

## Are All Environmental Chemicals Dangerous?

*No.*  Even organic foods grown without pesticides are swimming in natural chemicals.

## Using a Mouse Model to Study Toxins

- To avoid exposing people to harmful chemicals, Lau uses rodents to study the interplay of genes and polyphenols.

## Modeling Metabolism: Chemical Travels 

## Damage Report: Liver, Kidneys, Bladder

## DNA Differences Can Influence Risk

- Our DNA affects:
- How we _metabolize_ polyphenols and other chemicals
- The function of proteins the genes encode
- Individual risk of contracting disease from chemical exposure

- Which functions do proteins have in processing chemicals?

- What do toxicogeneticists study?

- Can you name a gene that has been linked to kidney cancer?

## Lau Links Genes to the Crime Scene

-  Lau is isolating genes that may increase the susceptibility of mice to chemically induced kidney cancers.

- Eker rats develop tumors when their kidneys metabolize toxic hydroquinone.
- Some humans have a similar gene, which may increase their susceptibility to kidney cancer.

**tumor**

## Lau’s Findings

- A gene directs the production of _tumor suppressor protein_
- When this protein is lacking, cells lose an important safeguard against tumors
- In some humans susceptible to kidney cancer, the tumor suppressor protein doesn’t work properly

## Research Applications

-    What is toxicogenomics, and how can it speed the development of new medicines?
# Presentation: 681801

## Human-Machine-Task CAD SoftwareMoldyn, Inc./Photon Research AssociatesCAMBRIDGE, MA

** **
**   ****ACCOMPLISHMENTS**
- Developed macromolecular version Multibody Order (N) Dynamics (MBO(N)D) using internal funds and a $2M Phase III grant from NIST/ATP funds
- Breakthrough solving equations used in the simulation of large molecules for long time periods
- Achieved 100 times speedup in simulating molecular dynamics
** ****COMMERCIALIZATION**
- Commercial potential in drug design was far greater than the original application of man machine interaction dynamics and performance analysis tool
- Photon Research Associates has spun off Moldyn, Inc. to commercialy develop this technology
- Commercial release of MBO(N)D code for Fall 1997 through Molecular Simulations, Inc., a major world-wide computational chemistry software retailer
- 1998 estimated sales - $2M

**S****MALL **
**B****USINESS**
**I****NNOVATION **
**R****ESEARCH**

- 1989 Phase 2; SS-155; 5/14/97

**GOVERNMENT/SCIENCE APPLICATIONS**
- Innovative polymers, composites for aerospace of interest to NASA Langley Research Center
- Biochemical molecules for sensing and computation - DoD
- Nanostructured materials of interest to NASA Ames Research Center, DoD and DoE
- Drugs for public health and military needs

- Goddard Space Flight Center

**INNOVATION**

- Very fast Order (N) algorithm for simulating
- biomechanical motion, spacecraft, vehicle and machine dynamics, and the dynamics of complex macromolecules
# Presentation: 760562

**John Pape, Epidemiologist**
**Communicable Disease Epidemiology Program**
**Colorado Department of Public Health & Environment**
**303-692-2628****	****	****john.pape@state.co.us**

- Sustaining WNV Prevention (Public Education) Programs

## Competing Public Health priorities
Old news
Message “burn-out”
Complicated message
Conflicting messages
Apathy
Hear message/ know message/ do nothing

- Old news
- Message “burn-out”
- Complicated message
- Conflicting messages
- Apathy
- Hear message/ know message/ do nothing

- Challenges

## Public Education Goals

- Consistent message
- Don’t over or under sell risk
- Personal responsibility

## The Four D’s

- Drain standing water where mosquitoes breed
- Dawn/Dusk when *Culex* mosquitoes feed
- Dress in protective clothes
- DEET containing repellents most effective

## Public Education Goals

- Refine message
- Be responsive to issues
- Target high risk groups
- Modify the message to the group
- Test, reassess and address
- Tailor message to surveillance defined risk

## Top 10 Reasons Why People Don’t Wear DEET Repellents

- 10.    Not sure why I didn’t use repellent

- 9.   Too lazy/ didn’t have time

- 8.  Used other methods to avoid mosquito bites

- 7.  Smells bad

- 6. (tie)  Didn’t have any repellent
-              Mosquitoes don’t bite me

## Top 10 Reasons Why People Don’t Wear DEET Repellents

- 5.   Don’t go outside

- 4.   Concerned about health effects of DEET

- 2.   Don’t see mosquitoes where I live

- 3.   Forgot

- 1.  Not worried/ not at risk

## Public Education Goals

- Educate decision/policy makers
- Surveillance system & what it means
- Mosquito control options
- Risk/benefits of mosquitocides
- Medical impact of WNV

## Slide 9

## 2003

**2003**

## July 26

## Slide 12

## Slide 13

## Ultimate Public Education Goal

- Prevent Human Cases
# Presentation: 744680

## Suspicious Activity Report Filing Trend for the District of ColumbiaFor the Period April 1, 1996 through December 31, 2007

**Suspicious Activity Report Filing Trend for the District of Columbia****For the Period April 1, 1996 through December 31, 2007**

***Total SARs: 9,823 ***

## Characterizations of Suspicious Activity for the District of Columbia

- Note:  The pie chart represents the top nine characterizations plus additional characterizations in total.
-            An individual SAR may cite more than one characterization.  Hence, the number of characterizations detailed here significantly exceeds the total number of SARs.

**Characterizations of Suspicious Activity for the District of Columbia**
**For the Period April 1, 1996 through December 31, 2007**

## District of Columbia Mortgage Loan Fraud SAR Filing Trend For the Period April 1, 1996 through December 31, 2007

**District of Columbia Mortgage Loan Fraud SAR Filing Trend ****For the Period April 1, 1996 through December 31, 2007**

- Note:  Suspicious Activity Report statistical data is continuously updated as additional reports are filed and processed.  For this reason, there may be minor discrepancies between the statistical figures contained in this report and those in previous FinCEN reports.  Annual numbers for this exhibit are calculated by ***Subject Address*** and not filer address; therefore, the annual totals appearing in the above graph do not match those in Section 1, Exhibit 8 (Characterization of Suspicious Activity by State & Territory by Year).

## Suspicious Activity Report Geographic Pattern for the District of Columbia

**For the Period January 1, 2006 through December 31, 2006**

**Note: Statistics based on Filer Branch Address**

## Suspicious Activity Report Geographic Pattern for the District of Columbia

**For the Period January 1, 2007 through December 31, 2007**

**Note: Statistics based on Filer Branch Address**
# Presentation: 005207

## SNAP Instrument Development

- Photo courtesy NOAO, taken with LBNL “hot red” CCD

- Supernova / Acceleration Probe:

**http://snap.lbl.gov**

- C. J. Bebek et al., “Proton radiation damage in p-channel CCDs  fabricated on high-resistivity silicon,” IEEE Trans. Nucl. Sci.  vol. 49, pp. 1221-1225, Jun. 2002.

- From “An assessment of the optical detector systems
- of the W.M. Keck Observatory,” J. Beletic, R. Stover,
- K Taylor, 19 January 2001.

**Taken near peak brightness **
**Covers 0.35 ********m to 1.7 ********m**
****** ****~ 100**
**Used to identify Type Ia SNe by SiII feature and characterize other**
**      ****features**

**Discover and follow ~2000 Type Ia SNe from z=0.3 to 1.7**
**Repetitive 4-day scans of ********square degrees******** **
**Light curves in 9 filter bands from 0.35 ********m to 1.7 ********m **

- SiII

- Metallicity

**SNAP Focal Plane**

**Photometry**

**Spectroscopy**

**Visible Light Sensors**

**Near-Infrared Sensors**

**Spectrograph**

**Sensor Electronics**

**Desired Features**
**Dark current < 0.02 e-/pixel/sec**
**Read noise < 4 e-**
**QE > 80% from 0.4 - 1.0 ********m **
**Charge diffusion: ********  < 4 ********m **
**Technologies**
**LBNL p-channel CCDs**
**Si PIN diodes**

**Desired Features**
**Dark current < 0.1 e-/pixel/sec**
**Read noise ~ 5 e-**
**QE > 65% from 0.9 - 1.7 ********m **
**Technologies**
**HgCdTe 1.7 ********m cutoff sensors from Rockwell or Raytheon**
**InGaAs sensors**

**Desired Features**
**High throughput, optimized for minimum exposure time for z=1.7 SNe**
**Spectral resolution ******** ~ 100 is sufficient to identify SiII feature of Ia SNe**
**Technology**
**Integral field unit based on image slicer technique**

**VIRGO 2048 x 2048 Arrays**** v**

**JWST NIRCam mockup**

**LBNL CCD:  Fully-depleted,**
**p-channel  technology on**
** ****high-resistivity silicon**

**SNAP v. 1 CCDs (4) on**
** ****DALSA-fabbed 150mm wafer**

**Spectrograph mounted**
**on back of focal plane**

**Spectrograph layout **
**showing visible and NIR arms**

**Imager Splitter Technique**

- Noise: 1.6e
- 2e @ 300 K

- 1.5 LSB non-linearity on high gain range. Much lower on other ranges.

- Four CDS channels
- Multi-slope integration
- 16-bit dynamic range
- Read noise < 2 e-
- Power 6.5 mW/ch

**CRIC chip designed **
**at LBNL**

- Diffusion vs bias voltage for
- 250 m thick LBNL CCD
- Presented at IEEE 8/03
# Presentation: 501066

## SNAP Secondary Support Diffraction

**24 August 2001**
**Michael Sholl**
**Space Sciences Laboratory**
**University of California at Berkeley**

## Assumptions:

**Snap is too fast for Fraunhofer’s approximation to Huygen’s integral**
**Analysis is performed in the far-field**
**Coherence length is infinite**

## Possible Configurations:

## Diffraction Limited Performanceof On-Axis System

**Diffraction Limited Performance****of On-Axis System**

## Four Radial Vanes:

## Eight Tangential Vanes:

## Three Radial Vanes:

## Six Tangential Vanes:

## Vanes Only:

## Conclusions:

**Radial vanes produce decaying (sinc) diffraction**
**Pairs of vanes produce lambda/spacing two-slit (slowly decaying) diffraction patterns**
**Radial vane configurations are superior for diffraction**