# Presentation: 007658

## caBIG Workspace Overview, Scope and Needs

- February 19 & 20

**caBIG Workspace Overview, Scope and Needs**
**Integrative Cancer Research**

## Contents

**Contents**

- Goals of this Session
- Workspace Structure
- Workspace Operations
- Workspace Participants and Scope
- Workspace Needs

## Workspace Breakout Session - Goals

- Learn about the relevant projects at the NCICB and at other Cancer Centers
- Review the needs and interests of participating pilot Cancer Centers
- Review requirements for developer projects and recommend specification and sequence for activities
- Evaluate existing and recommended projects as the basis for testing and integration by Adopter Centers
- Discover sources of data within the Workspace which can be shared on the grid as part of the pilot program
- Discuss group coordination and future meeting schedule
- Draft action plan summarizing conclusions

## Purpose of this Presentation

- Start today’s discussion from a common understanding
- 	- Overview of caBIG Workspaces in general (structure and operations)
- Set the stage for the Workspace specific discussions
- 	- Understand the scope and needs of the Integrative Cancer Research Workspace

## Contents

**Contents**

- Goals of this Session
- Workspace Structure
- Workspace Operations
- Workspace Participants and Scope
- Workspace Needs

## Workspace Definition

- Central structures of the caBIG pilot initiative
- Areas where caBIG pilot project activities are grouped and coordinated
- Encompass activities with a common focus, addressing identified Cancer Center needs
- Create products and solutions including tools, standards, data and documentation
- Share and test products and solutions amongst pilot participants
- Develop products and solutions which will ultimately be open and shared among the cancer research community

## Workspace Types

- There are two types of Workspaces – Domain and Cross Cutting
- Integrative Cancer Research is a Domain Workspace

## Workspace Roles

**Developer**
- 	An NCI-designated Cancer Center selected and funded by NCICB to participate in a specific Workspace to undertake software or solution development activities.
**Adopter**
- 	An NCI-designated Cancer Center selected and funded by NCICB to undertake formal testing, validation and application of products or solutions developed by Workspace Developers.
**Workspace Working  Group**
- 	A group of NCI-designated Cancer Center members (and other invited stakeholders) funded to provide guidance and support for Workspace activities.  The Working Group includes representatives from the Developer and Adopter teams.

## Workspace Roles

**Cross Cutting **
**WORKSPACE**

**Architecture**

**Vocabularies & Common Data Elements**

**Cross Cutting ****WORKSPACE**

**Developer**

**Developer**

**Adopter**

**Developer**

**Developer**

**Adopter**

**Developer**

**Developer**

**Developer**

**Developer**

**Developer**

**Workspace**
**Working Group**

**Workspace**
**Working Group**

**Workspace**
**Working Group**

**Domain **
**WORKSPACE**

**Clinical Trial Mgmt System**

**Integrative Cancer Research**

**Tissue Banks & Pathology Tools**

**Workspace**
**Working Group**

**Workspace**
**Working Group**

**Adopter**

**Developer**

**Developer**

**Adopter**

**Developer**

**Developer**

**Adopter**

**Domain **
**WORKSPACE**

**Domain **
**WORKSPACE**

## Contents

**Contents**

- Goals of this Session
- Workspace Structure
- Workspace Operations
- Workspace Participants and Scope
- Workspace Needs

## Workspace Principles of Participation

- Support the spirit, vision, goals and principles of the caBIG initiative as a whole
- Collaborate effectively with other Workspace participants and groups to support specific and overarching goals
- Collaborate effectively with other Workspaces and Working Groups (Workspace and Strategic levels) to support specific and overarching goals
- Undertake activities with integrity and objectivity
- Perform activities in a consensus driven manner
- Respect and capitalize on the skills and merits of individual participants
- Act in accordance with the caBIG Oversight Board and Master Contractor guidelines and processes

## Workspace Communications 

- The success of the caBIG network relies on communication and coordination between caBIG participants
- Mechanisms will be established to ensure effective communications both within Workspaces and between Workspaces/Working Groups
- e.g., Face-to-face meetings
- e.g., Electronic Program Updates
- e.g., Web based tools
- The Cross Cutting Workspaces and the Strategic Level Working Groups address issues of common concern across caBIG and will promote communications across Workspaces

## Workspace Performance

- As part of undertaking Workspace activities, Workspace participants are asked to:
- Perform in accordance with their contracts and charters
- Meet agreed work plans, milestones and deliverable schedules
- Support processes as delineated by the caBIG coordination and oversight groups, including those for performance planning, monitoring and reporting
- Support the vision, goals and principles of caBIG
- Perform activities within agreed scope and budget

## Workspace Coordination

- Workspace participants are responsible for the coordination of their Center level caBIG related projects and activities according to agreed Statements of Work and contracts
- Overarching coordination of Workspace activities is undertaken by the Master Contractor (contracting team appointed by NCICB)
- Workspace participants are asked to support processes established by the Master Contractor to ensure the coordination of caBIG activities

## Contents

**Contents**

- Goals of this Session
- Workspace Structure
- Workspace Operations
- Workspace Participants and Scope
- Workspace Needs

## Workspace Participants – Integrative Cancer Research

## Integrative Cancer Research Workspace Scope

- This Workspace provides tools and systems to enable integration and sharing of information among cancer researchers
- These tools will ultimately:
- Facilitate the integration of data not only from different centers, but also data of different types
- Enable translational and integrative research
- Provide for the integration of data from “bench to bedside”, “bedside to bench” and from “bench to bench”

## Integrative Cancer Research Workspace Scope

**This Workspace focuses on:**
- Extension and implementation of tools to enable researchers to integrate and share data collected from a variety of heterogeneous sources
- Data sources will include de-identified patient clinical data and information collected from a variety of high-throughput research techniques
- caBIG-enable a wide range of tools particularly useful to cancer researchers, with a focus on enabling translational research
- Make data and analytical bioinformatics methods more useful to cancer researchers
- Data and analysis should be capable of being shared with colleagues, and transparently integrated with other, related data

## Contents

**Contents**

- Goals of this Session
- Workspace Structure
- Workspace Operations
- Workspace Participants and Scope
- Workspace Needs

## The common needs helped shape priority areas for the caBIG pilot activities 

**Clinical Trial Management Systems**

**Tissue ****Banks ****& Pathology**

**Integrative Cancer Research**

**Notes:**
Three areas of critical need were identified based on this information and these facilitated the groupings of pilot project activities into three Workspaces:
(1)	Clinical Trial Management Systems
(2)	Integrative Cancer Research
(3)	Tissue Banks and Pathology Tools

## Integrative Cancer Research: Center Needs

**Example needs within the Workspace, from August 2003 Cancer Center Cooperative Development Meetings.**
- Need a comprehensive bioinformatics infrastructure to support the integration of clinical and basic science data   (10+ Centers)
- Need community-shared platforms for sharing data with collaborators  (Multiple Centers)
- Managing large amounts of data challenging
- Better Gene Expression tools
- Want access to large amount of gene expression data, especially in breast cancer
- Better caBIG systems for handling and exchanging pathway data
- Need tools for cross-platform analysis of proteomics data
- Posting of raw data for data mining as opposed to just results ( E.g. research data warehouses)
- Need access to data from other Cancer Centers