BEE-spoke-data/govdocs1-by-extension huggingface dataset:
# Presentation: 191807

## Radioimmunotherapy

- Allison Spencer
- July 27, 2006

## Radioimmunotherapy

- Uses the body’s immune system to deliver toxic radiation to cancerous cells
-  Special combination of factors:
- Tumor antigen targeting
- Monoclonal antibodies
- Radionuclides
- Localized treatment

## Bio 101: Antigens

- Molecules that stimulate an immune response
- Proteins or polysaccharides on cell surfaces
- Many different types
**Tumor Antigens**
- Tumor Associated
- Tumor Specific

## Bio 101: Antibodies

- Large, Y shaped proteins
- Identify and neutralize antigens
- Induce apoptosis
- Cell cycle redistribution
- Multiple antibodies for every antigen

## Monoclonal Antibodies

- Highly specific
- Clones of single cell
- Fuse B cell and tumor cell
- Screen for antibody production

## Radioimmunotherapy

- Adds a radioactive molecule to a monoclonal antibody (MoAb)

- Yttrium 90 labeled MoAb

## Non-Hodgkin’s Lymphoma

- 58,870 cases will be diagnosed in 2006
- 5th leading cause of cancer death
- Traditionally treated with:
- Chemotherapy
- External beam therapy
- Immunotherapy

## RIT and Non-Hodgkin’s Lymphoma

- Specific antigen targeted: CD20
- Tumor associated
- Does not shed or internalize
- Isotopes used:
- Yttrium-90:	half life 64 hours, beta emitter
- Iodine-131:	half life 8 days, alpha and gamma
- Vary in conjugation

## Process of Attack

- <date/time>

**90****Y**

_*Cancerous B Cell*_

## Advantages of RIT

- Precision of treatment
- Less damage to healthy tissue
- Irradiation of nearby, unbound cells
- Patient comfort
- 1 hour intravenous procedure
- Y-90 outpatient administration

- Unbound cells receive toxic radiation

## RIT Success in NHL

- With traditional treatments:
- Low grade kills ~95% of patients in first 5 years
- Aggressive kills ~50% of patients in first 5 years
- Yttrium-90 labeled Zevalin:
- 80% overall response rate with Y-90 Zevalin
- 34% complete response
- 32% still in remission 3-4 years later

## Radioimmunotherapy

- Allison Spencer
# Presentation: 063401

## Helvetica 96

** Work supported by US DOE Contract No. DE-AC02-76CH03073 *

**TITLE****** ***

**Print Menu**

**Directions: Page Setup**

**Font Sizes**

- Page setup

- In print under copies and pages, check that printer E354_HP5000PS is chosen
- Ensure “Scale to Fit Paper” box is NOT checked

- Set format for E354-HP5000PS
- Paper Size 36” X 72”
- Orientation chose a landscape
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- (this uses full printable area of printer)

- Helvetica 80
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- under Paper Handling Check that custom size 36” X 72” is chosen
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- Preview saves time and paper; it takes over 20 minutes to print
- Even canceling at the printer takes over 20 minutes

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- Note:I used Helvetica 28 for the Directions, Helvetica 88 Bold for Title. Helvetica 44 for Author list
- Helvetica 18 for “Work supported...”, Helvetica 36 Bold for titles in boxes  This is Helvetica 20
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- Author list - *PPPL, Princeton, NJ USA*
- Other institution authors - *Institution*

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- Orientation, slide, landscape image

- Select Options

- In the Options window

- Presented at some wonderful meeting in some beautiful city on month, day, year
# Presentation: 108887

## C/Sr. Airman DDR

**C/A1C DDR**

**C/Airman DDR**

**C/Basic DDR**

**C/SSGT**

**C/Sr. Airman**

**C/A1C**

- _[C/Airman](slide8.xml)_

- _[C/Basic](slide4.xml)_

**C/SSGT DDR**

- Are You Smarter Than An C/SSGT?
- Developed by 1st Lt Jeff Frame, UTWG DDRA

## What drug can the following ingredients be used to make?:  Paint thinner, iodine, kerosene, battery acid and cat litter.

## Meth

## What are the 3 missions of CAP?

## Emergency Services2.  Aerospace Education3. Cadet Programs

## What percentage of crystal meth users reporting addiction-like cravings after first use.

## 50%

## What is the Honor Code?

## “ We will not lie, steal or cheat, nor tolerate among us anyone who does.

## Brown sugar, dope,H, horse, junk,skag, skunk,smack, white horse; are street names for what drug?

## Heroin

## What is the name of this grade?

## Lt. Colonel

## What is the most deadly drug used by teens?

## Alcohol

## What are the 3 overlapping components of followership?

## The Job2.  Leader-follower relationship.3.  Your responsibility to yourself.

## How many times more likely are you to develop alcohol problems by  starting to drink around or before age 15 then at age 21.

## 5 times.  A person who starts drinking at the legal age of 21 has only a 7% chance of becoming addicted.  (a person who doesn’t ever start drinking has a 0% chance.)

## What are the 3 axes of an airplane?

## Lateral (Pitch)2. Longitudinal (Roll)3. Vertical (Yaw)
# Presentation: 382756

## Motorcoach Emergency Egress

## Wilmer Accident Situation

- Occupants with special needs
- Rapid fire propagation
- Passenger survivability compromised by limited evacuation time

## Emergency Egress Issues

- No recent studies on motorcoach egress
- Emergency window exit design

## Evacuation Studies

- 1976 motorcoach evacuation study
- Emergency exit standards
- Aircraft 90-second rule for egress
- 1984 paratransit bus study
- Exit windows too heavy to push open
- Exit windows too difficult to open from outside

## Emergency Egress Research

- Drills for aircraft evacuation
- Simulation of aircraft evacuation
- 2001 FRA interim report on railcar fire safety, egress time

## Motorcoach Evacuation Simulation

- May include fire, smoke, or panic situations
- No requirement to demonstrate that passengers can escape
- Need to evaluate egress

## Current Window Design

- Requirements for opening force
- 7–8 feet above ground
- Weight up to 45 lbs or more
- Hinges at top

## Window Exit Issues

- Rescuers cannot open windows from outside
- Windows impede evacuation

- Source: Dallas County Sheriff’s Office

## Summary

- No recent industry- or Government-sponsored research on emergency evacuation
- Critical need to evaluate egress
- Simulations needed to evaluate evacuation capabilities

## Slide 11
# Presentation: 016437

## National Vaccine Advisory Committee

- A Status Report on the
-  Pediatric Vaccine Stockpiles
- February 8, 2005

**Eddie Wilder**
**Project Officer, Pediatric Vaccine Stockpile**
**Immunization Services Division (ISD)**
**National Immunization Program (NIP)**

## Agenda

**History of Stockpiles**
**Current Status of Pediatric Stockpiles**
**Stockpile Challenges**
**Resolution Options**
**Next Steps**

## Background

**01/83****	****Began stockpiling pediatric vaccines**
**01/93****	****VFC legislation enacted; established ****	****	****requirement for 6-month stockpile of ****	****	****all routinely recommended childhood ****	****	****vaccines**
**09/02****	****GAO issues report entitled “Childhood ****	****	****Vaccines, Ensuring an Adequate ****	****	****	****Supply Poses Continuing Challenges” **
**10/02****	****NVAC recommends enhancement of ****	****	****CDC vaccine stockpile**

## Accomplishments

**Logistics Management Institute (LMI) work begun**
**Broad strategic plan developed**
**Booz Allen Hamilton (BAH) contract initialized; Vaccine Management Business Improvement Project (VMBIP) ongoing**
**Reached target quantities on MMR and Varicella; partial target quantities of vaccine for Hep A, Hep B, Hib, and e-IPV**

## Pediatric Vaccine StockpileTarget QuantitiesJanuary 2005

## Pediatric Vaccine StockpileDoses PurchasedJanuary 2005

## Current Status of the Pediatric Vaccine StockpileJanuary 2005

## Current Status of Stockpile Contracts

**Aventis**
**Current Storage and Rotation Contract**
**Purchased product for stockpile**
**Contract issues  **
**Merck**
**Current Storage and Rotation Contract**
**Purchased product for stockpile**
**Contract issues  **
**GSK**
**No storage and rotation contract**
**No vaccines delivered to stockpile**
**Wyeth**
**No storage and rotation contract**
**No vaccines delivered to stockpile**

## Pediatric Vaccine Stockpile

**Revenue recognition issues have delayed stockpile build-up progress**
**SAB 101 has 7 requirements**
**All four (4) manufacturers are affected by revenue recognition**
**HHS has 90-days to develop plan to resolve **

## Pediatric Vaccine Stockpile

**CDC has developed alternate models**
**Annual fee model**
**Pros:**
**Resolves revenue recognition issue with no major operational changes**
**Easier to manage expiration risk**
**Cons:**
**May result in unreasonable cost to CDC**
**May result in accounting constraints at the manufacturer**
**Requires significant negotiation on value for operating fee**

## Pediatric Vaccine Stockpile

**CDC has developed alternate models**
**Off-site storage model**
**Pros:**
**Resolves revenue recognition issue**
**Provides greater assurance of  stockpile availability**
**Cons:**
**Requires consolidated distribution approach – impacts implementation timing**
**Dramatically increases CDC liability and risks of vaccine expiration**

## Next Steps

**Resolve revenue recognition issue**
**Review and revise contracts with two (2) manufacturers who have existing stockpile contracts**
**Include new manufacturers in stockpile process**
**NVAC’s particpation in target quantity workgroup**
# Presentation: 701546

## MPC&A ProgramInternational Cooperative License (ICL)

- Dr. Ronald R. Rudolph
- National Nuclear Security Administration NA-25

## Status

- Since 11/97, processed over 1,300 ICL requests for over 1,500,000 items worth over $105M, $40M in last 12 months
- Reviewed over 150 IVL applications
- Processed 39 General NRC Licenses for nuclear sources

## Status (cont.)

- Successful Commerce compliance reviews  of ICL activities at LANL, SNL, DOE/HQ, ANL, and Y-12, None since 9/11/01
- Added 98 consignees to the ICL
- Added 2 new users - NNSI & ORNL
- Updated ICP six times
- Submitted 10 semi-annual assurance reports

## Issues

- Sharing sensitive technology
- Assurances for three years after complete site
- Transfer custody of assurance documents
# Presentation: 304433

## Development Checklists

- 4R PS&E

## Objective of the Development Checklists

- Provide a concise list of elements for 4R PS&E development.
- Provide consistency among PS&Es.
- Identify the point when key activities crucial to the advancement of the PS&E should be completed.

## Checklist Milestones

- 15%
- 30%
- 50%
- 70%
- 95%
- 100%

## Use

- Each checklist progressively advances the project elements.
- Activities required to advance the design to the next phase are included to place emphasis on completing those activities at the appropriate time.

## Use

- The originator initials each element that is completed, marks “I” for incorporation, or marks N/A if element is not applicable.
- Having the originator validate that they have completed each element allows a significant number of those elements to be advanced without further review.

## Slide 6

## Changes

- Key design element are advanced into the 50% & 70% submittals
- Reduced effort has been built into the 95% & 100% submittals
- 95% PS&E is considered advertisement ready
- 100% PS&E is essentially a delivery checklist

## Results

- Lessens the last minute massive design effort
- Provides for a complete review package at 70%
- Controls the advancement of development and identifies causes for slip.
- Improved Quality

## Location of Checklists

- The checklists are located under the Design Resources tab on CFLHD’s website found at _[http://www.cflhd.gov/design/index.cfm](http://www.cflhd.gov/design/index.cfm)__._

## What’s Next

- Development of a 4R PS&E review checklist that provides a complete record of the elements reviewed.
- The checklist identifies those elements that are key to the quality of the PS&E.
- Does not include the minor elements that are validated by the Development Checklists.
# Presentation: 526335

## Thriving Through Partnership 

**October 3 & 4, 2005**
**Chicago Marriott O’Hare Hotel **

## DoD/VA Joint Contracting for High-Tech Medical Equipment

**Agenda**
- History
- Current Joint Contracts
- New Joint Radiology Contracts
- Benefits of Joint Contracts
- Questions

## History

**Congressional Mandate to Cooperate**
**Memorandum of Understanding between DoD and VA**
**Appendix 3 – Medical Equipment**

## Current Joint Contracts

**Sep 2002 – Joint Contracts for Imaging (Radiology) Maintenance Services awarded.**
**2003 – Joint Contracts for Radiation Oncology (Therapy) awarded.**
**2003/2004 – VA NAC and DSCP Open Ordering Authority to Radiology Contracts**
**2005 – VA NAC Transitions to DSCP Imaging (Radiology) Contracts**

## New Joint Radiology Contracts

**Current DSCP contracts expire Feb 2007**
**Joint solicitation to be issued by the VA NAC in Oct/Nov 2005.**
- Unique requirements of both agencies
- Vendor contract awards to be equally split between agencies
- VA NAC and DSCP will technically review all proposals

## New Joint Radiology Contracts

**Scope:  all Radiology (Imaging) equipment items, except DIN-PACS**
**Term:  8 years total.**
- Base term of 1 year with 7 one year options.
- Open seasons every year
**Delivery orders will continue to be issued as they were under previous contracts.**

## Benefits of Joint Contracts

**Vendor Benefits**
- One Government contract, one pricebook
- Less contract administration effort
- Easier product and price updates
- Common terms and conditions (where possible)
**Government Benefits**
- Eliminates duplicate contracting work
- Easier to leverage purchases for both agencies to obtain volume pricing (future)

## Benefits of Joint Contracts

**Customer Issues?**
- No Change in order placement.
- Agencies will continue to issue orders for their own customer base as they always have.

## DoD/VA Joint Contracting for High-Tech Medical Equipment

**Q&A**
**Andrew Wechter                                                                     Acting Chief, Medical Equipment CBU**
**	****Defense Supply Center, Philadelphia**
**	****215-737-4114**
**	****andrew.wechter@dla.mil**
**	**
**Copy of Presentation will be made available after 5 p.m. on October 4**** ****at**** **_**[www.va.gov/vastorenac](http://www.va.gov/vastorenac)**_
**	****	****	****	****	****	*****Thank You***
# Presentation: 205157

## DAQ Monitor Tutorial

- T. Yasuda
- Fermilab

## Introduction

- Purposes
- Performance monitoring during a run.
- Performance tuning tool during commissioning.
- Diagnostic tool in case of problems.
- Program
- Server (DM_Server) and Client (DAQ_Monitor.py) system.
- Communicates with DAQ system elements using itc.
- Client displays information using Python/Tkinter GUI modules.

## How it works

- DM_Server is:
- an itc server with an itc processor to handle messages.
- Contains a DM_Task class object.
- DM_Task class object contains client objects for DAQ processes, e.g. TCC, Distributor, etc.
- The clients objects are private data members of DM_Task class.
- Data received from the DAQ processes as an itc message are handled by a callback method of the client object that requested the data.

## How it works

- Requests data to the DAQ processes by sending an itc message.
- Communicates with receiver clients (Display clients).
- Receiver clients send a string message to request data from the DM_Server.

## Trigger/DAQ Monitor

**Trigger/DAQ**
**Monitor **
**Server**

**Data**
**Logger**

**Monitor**
**Display**

**L3**

**L1/**
**L2**
**TCC**

**Data**
**Distributor**

**EXAMINE**

- T. Yasuda	4/26/99
- Updated             5/18/01

## Software

- A cvs package: daq_monitor
- Written in C++ (server) and python (display client).
- Uses itc for communication.
- Different message types for individual sub-processes that run C++ server/client.
- String and opaque messages only for python (display) clients.
- Messages are encoded/decoded in XDR.
- Compiles on Linux.

## Instructions

- To start the DAQ Monitor server
- setup d0online
- start_daq_monitor_server
- or start_daq daq_monitor_server
- To start a DAQ monitor display client (from any online node)
- setup d0online
- start_daq_monitor_display
- or start_daq daq_monitor					  start_daq daq_monitor_small

## Slide 8

## Slide 9

## Slide 10

## Slide 11

## Slide 12

## Slide 13

## Slide 14

## Slide 15

## Slide 16

## Slide 17
# Presentation: 697700

## Quality and Secondary Uses of Health Data

- July 11, 2007
- Jon White, MD
- Health IT Director, AHRQ
- AHIC Consumer Empowerment Workgroup

## Some Current Activities

- AHIC Quality WG - NQF Health IT Expert Panel
- HQA/BAH Hospital Quality Reporting report
- http://www.hospitalqualityalliance.org/hospitalqualityalliance/resources/resources_page.html
- AQA Data Sharing and Aggregation WG
- http://www.aqaalliance.org
- National Health Data Stewardship RFI
- http://a257.g.akamaitech.net/7/257/2422/01jan20071800/edocket.access.gpo.gov/2007/07-2733.htm
# Presentation: 708702

## FEA boundary conditions and geometry

- Pressure load = 2.027×107 Pa (2 atm)
- Fixed support at power coupler and beam tube
- Flat rib   40mm×4mm thick
- Tubular Rib  24.65mm ID, 4mm thick
- Gussets  62.3mm × 38mm high × 4mm thick

## Niobium Properties

## Single Spoke Resonator - NO RIB

## Single Spoke Resonator - NO RIB

- Total deformation

- Von Mises Stress

## Single Spoke Resonator - FLAT RIB

## Single Spoke Resonator - FLAT RIB

- Total deformation

- Von Mises Stress

## Single Spoke Resonator - TUBULAR RIB

## Single Spoke Resonator - TUBULAR RIB

- Total deformation

- Von Mises Stress

## SSR - FLAT RIB + GUSSETS

## SSR - FLAT RIB + GUSSETS

- Total deformation

- Von Mises Stress

## SSR - TUBULAR RIB + GUSSETS

## SSR - TUBULAR RIB + GUSSETS

- Total deformation

- Von Mises Stress

## Summary

| Reinforcement Type | Total Deformation
[m] | Von Mises
[MPa] |
| --- | --- | --- |
| none | 329 | 352.8 |
| flat | 283 | 256.0 |
| tubular | 266 | 254.4 |
| Flat + gussets | 137 | 65.08 |
| Tubular + gussets | 109 | 65.85 |
# Presentation: 337067

## 5th Annual NIH American Indian/Alaska Native 

**Heritage Month Program**

**November 8, 2005**
***“******Research in American Indian and Alaska Native Communities”***
- 12:30 – 2:00 p.m., Poster Session 2:00 – 3:30 p.m.
- Building 38A, Lister Hill Center Auditorium

*Welcome**	**	****NIGMS Director Jeremy M. Berg, Ph.D.***** **
*12:30PM-12:45PM**	**Barbara V. Howard, Ph.D. - Medstar Research Institute*
*	**	****The Strong Heart Study***
*12:45PM-1:00PM**	**Tam Lutz, MPH - NW Portland Area Indian Health Board*
*	**	****Toddler Overweight and Tooth Decay Prevention Study***
*	**	**(Primary prevention of dental caries and type 2 diabetes)*
*1:00PM – 1:15PM**	**Michael J. Carvan III, PhD - **Great Lakes Native American Research Center for **	**	**Health*
*	**	****A Zebrafish Model of the Protective Effects of Traditional Diet: ******	******	******Mercury-Selenium***
*1:15PM – 1:30PM**	**Peter O. Ogunbiyi, DVM, Ph.D. - National Cancer Institute*
*	**	****Breast Cancer Education for Native American Women***
*1:30PM – 1:45PM**	**John Walkup, M.D. - White Mountain Apache Tribe*
*	**	****Youth suicide prevention using community-based, participatory ******	******	******research (CBPR) methods to design and implement the Apache ******	******	******Youth suicide Research and Prevention Program***
*2:00PM-3:30PM NARCH **	**Poster Session*

*Joseph Marshall III, a teacher, historian, Lakota craftsman and author will give a storytelling presentation entitled ****“Lakota Traditional Healing and Cultural Issues with Contemporary Health Care Delivery”***

- Events Coordinated By:  NIH American  Indian Alaska Native Employee Council (AIANEC)
- Sponsored By: NIH Office of Equal Opportunity and Diversity Management (OEODM)
- Department of Health and Human Services, National Institutes of Health
- Sign Language Interpreters will be provided. Individuals with disabilities who need reasonable accommodation to participate in this program should contact Marianne Hamilton, OEODM on 301-451-0748 (v) or by Federal Relay Service 1-800-877-8339 (TTY).
- For information on Visitor Access to NIH:  _[http://www.nih.gov/about/visitorsecurity.htm](http://www.nih.gov/about/visitorsecurity.htm)_
- For additional information about the program:  _[http://oeodm.od.nih.gov/aianep](http://oeodm.od.nih.gov/aianep)_

- November 9, 2005
- Joseph Marshall III
- 11:30-12:30 p.m.
-  Masur Auditorium, Building 10: Reception to Follow
# Presentation: 284667

## NIH Electronic DirectoryProof of Concept -Hybrid DIT

- Robert M. Malick
- rmalick@nih.gov

## Definition

- Demonstrate the ability to create a metadirectory using a hybrid DIT via SAC tables and HRDB data using Zoomit Via software
- demonstrate that COTS products can access metadirectory data via LDAP
- demonstrate information update, access control, searching, modification in Zoomit

## DIT Structure

- Organizations
- deep tree of ICs created from SAC tables and their inherent structure
- Person information
- flat and deep trees populated with person info from HRDB
- deep namespace person entries will reference entries in flat namespace

## Questions To Be Answered

- Will SACs be sufficient to construct a deep organizational tree?
- Will SACs in HRDB records be sufficient to populate entries in deep organizational tree?
- What might be the best format for “ou” attributes in nihOrgPerson schema (e.g., OU=CIT/CFB vs. OU=CIT,OU=CFB)?
- Is it better to use aliases or copies of information in the deep tree?

## Questions To Be Answered (cont.)

- What RDN issues are involved with COTS products?
- Can we update the DIT structure after it has been constructed?
- Does the DIT provide sufficient security and access control?
- Zoomit Via performance, administration, and replication aspects.
# Presentation: 703831

## ESA Dose Adjustment in Dialysis Patients:  Implications for ESA Prescribing Information

*Robert Provenzano, MD *
*DaVita*

## Relationship between degree of dose reduction and Hb outcomes in patients with initial Hb 12-13 g/dL or Hb > 13 g/dL

- Cohort-1 (Hb 12-13g/dl)
- Hemodialysis Patients
**Hb 12-13 g/dL** end of month, December 2006
- Level of dose decrease in January 2007
- 10-25%, 26-50%, 51-99%, or 100%
- Follow month-to-month Hb changes through June 2007

- Cohort-2 (Hb >13g/dl)
- Hemodialysis Patients
**Hb > 13 g/dL** end of month, December 2006
- Level of dose decrease in January 2007
- 10-25%, 26-50%, 51-99%, or 100%
- Follow Hb changes through June 2007

## Holding Epoetin alfa when Hb is 12-13 g/dL increases relative risk of both low Hb early and high Hb later

*Source:  *DaVita internal data

## Holding at Hb > 13 increases risk of Hb < 11 early, > 13 late

*Source:  *DaVita internal data

## Larger epoetin dose reductions are associated with higher epoetin dose requirements

*Source: **	*Data from Thamer M et al. *JAMA *297 (15):1667-1674, 2007, 	Table 2.

## Better anemia management is also associated with higher epoetin dose requirements

*Source: **	*Data from Thamer M et al. *JAMA *297 (15):1667-1674, 2007, 	Table 2.

## Trend in Standardized Mortality Ratio (SMR) for all Dialysis Patients, 1985-2002 

***-19%***

## Administer EPOGEN® at the lowest dose needed to achieve 

**Administer**** ****EPOGEN® at the lowest dose needed to achieve **
**a hemoglobin > 11g/dL. Decrease the EPOGEN® dose if **
**the  hemoglobin  exceeds  12g/dL  or the hemoglobin rate **
**of rise exceeds 1g/dL per two weeks or 2g/dL per 4 weeks.**

## Conclusions

- Create Policies & warning specific to the CKD/ESRD population
- Do not encourage withholding epoetin alfa as standard practice or making large dose decreases for Hb values above target:
- Dangerous
- Increases risk of early, serious anemia
- Counterproductive
- Increases risk of later, above-target Hb
- May increase epoetin utilization
- Current CMS regulations and Clinical Performance Measures
- Are safe, sufficient, and well-supported by evidence
- Do not underestimate or undervalue QOL...
# Presentation: 196863

## Pathway Database

- Carl Schaefer
- February 21, 2003

## Why Spend Effort on Pathways?

- Target as process vs. target as molecule
- In the end, what matters is a hyperactive process (e.g. mitosis), not just an over-expressed protein
- Phenotype classification
- Higher-level feature than transcript abundance

## Why Spend Effort on a Pathway Database?

- A picture may be worth a thousand words ...
- but a computable representation is even better
- Make assumptions explicit
- Combine sources of data
- KEGG, BioCarta, ...
- Merge data from separate pathways
- E.g. BioCarta’s “Cyclins and Cell Cycle Regulation” and “Cyclin E Destruction Pathway”
- Causal framework for quantitative simulation/analysis
-  ... when the data becomes available

## Basics

- Model a causal network
- Be composable (novel pathways)
- Cope with lack of knowledge
- Promote understanding

## Model A Causal Network

- Graph (nodes & edges)
- Distinguish two kinds of nodes (molecules & processes)
- Allow labels on nodes and edges
- molecule-type (compound, protein, complex, rna)
- molecule-id (...)
- process-type (reaction, binding, modification, translocation, transcription, cell process)
- edge-type (input, output, agent, inhibitor)
- activity-state (active, inactive)
- location (extracellular, transmembrane, cytoplasm, nucleus)
- reversible (yes, no)

## Composable

- “Atomic pathway”
- a process node
- immediately adjacent molecules
- the connecting edges
- Join atomic pathways on identical molecules
- ... and maybe on molecule subtype relation

## Pathway Construction:Joining Atomic Pathways

## Lack of Knowledge

- Hierarchy of label values
- e.g., edge-type  incoming-edge  agent
- Hierarchy of molecule ids
- GO id
- Gene product
- Specific protein
- Families of molecules
- “Handbook”
- E.g.: “for Raf-1, ‘active-1’ means phosphorylation at S259”

## Promote Understanding

- Hide unwanted detail
- prune common molecules
- encapsulate sub-pathways
- Query by connectedness (cause & effect)
- Find patterns

## Omission of Don’t Care Detail:Pruning Common Compounds

## Query by Connectedness:Predecessors/Successors

- atom-id = 411
- direction = forward
- degree = 3
- prune common compounds

## Patterns

- Templates for atomic pathways:
- process-type=modification::
- molecule-type=protein[1]:edge-type=agent::
- molecule-type=protein[2]:edge-type=input:activity-state=inactive::
- molecule-type=protein[2]:edge-type=output:activity-state=active
- Maybe multi-process templates (e.g., a cascade)

## What Do We Need?

- Computation model of pathway interactions
- Persistent data model
- Tools:
- data input
- query and analysis
- visualization
- Data, data, data, ...

## What Do We Have?

- Computation model: mostly worked out
- Persistent data model: mostly worked out
- Tools:
- working on data input
- have a query/analysis tool
- joins, prunes, finds predecessors/successors
- produces graph output
- extracts first-order patterns
- using GraphViz to produce SVG diagrams
- Data, data, data ...
- Loaded KEGG into database
- Next: ~30 BioCarta pathways related to apoptosis, cell-cycle regulation and histone deacetylase activity
# Presentation: 246361

## Tribal Issues & Project DeliveryCase Studies & Lessons LearnedFederal Highway AdministrationWashington Division 

- Tribal Issues & Project DeliveryCase Studies & Lessons LearnedFederal Highway AdministrationWashington Division

- FHWA Environmental Meeting, June 29, 2004
- Sharon P. Love, P.E.Environmental Program Manager, FHWA WA Division

*Eloise Best, Colville*

## Tribal Issues and Project Delivery 

- Some Project-Specific Examples:
**Traditional Cultural Properties** – Upriver Drive in Spokane County – Delayed 4 years, Mitigation Cost $40,000
**Treaty Rights** – Edmonds Crossing – Delayed 3 years Mitigation Cost $5 million +
**Archaeology** – Hood Canal Bridge – Delayed 1 year Mitigation cost $4.5 million FHWA $3.4 million WSDOT, Delay claim – as much as $30 million

## Spokane County Upriver Drive Coyote Rocks – TCP

## Spokane County Upriver Drive Coyote’s Rocks – TCP

- Minor project – sidewalks and shoulder widening.
- Documented CE
- County lead.
- TCP listed on the National Register of Historic Places missed in early review and on DCE.

## Upriver Drive, Spokane County Coyote’s Rocks

- Upriver Drive, Spokane County Coyote’s Rocks

*Lessons Learned/Results*
- Education of Local Agencies –ensure National Register is checked.
- Early involvement with Tribes.
- Importance of Government-to-Government relationship at the Federal level.
- Revisions to checklist used for Documented Categorical Exclusions.

## Edmonds Crossing 

- Edmonds Crossing

- Tribal Fishing Area

- New Alternative

## Edmonds Crossing 

*Lessons Learned*
- Possible impacts on Tribal treaty rights need to be addressed early.
- Tribal input can greatly improve a project – even more so if it is received early (ideally before the Draft EIS is circulated).
- There is more to tribal coordination in NEPA than Section 106.

## Hood Canal Bridge

- Port Angeles
- Graving Dock

- Hood Canal Bridge

## Hood Canal Bridge

- Late Discovery of Archaeology
- Choices:
- Terminate contract, further delaying HCB replacement
- Figure out a way through the Section 106 process

## Hood Canal BridgePort Angeles Graving Dock

- Lessons Learned
- Importance of FHWA andWSDOT involvement with the Tribe early in NEPA.
- A good monitoring plan is essential – it worked well in this case.
- Face-to-face meetings.

## What are we doing to improve coordination with Tribes in WA?

- Early notice of projects (during planning)
- Annual Meetings with SHPO and Tribes
- Review of Metropolitan Planning Organizations to ensure Tribal projects and issues are addressed in their plans.

## What are we doing to improve coordination with Tribes in WA?

- Programmatic Agreements on Section 106 Consultation
- Government-Government Training WSDOT’s Tribal Liaison Office presents  training for transportation employees on Section 106 and TERO. WSDOT is training 250 of their staff each year.

## For further information:

- Sharon Love sharon.love@fhwa.dot.gov360.753.9558
- FHWA Washington Division website:	www.fhwa.dot.gov/wadiv
- Washington State DOT website:
- 	www.wsdot.wa.gov
# Presentation: 065188

## Mars Colony

- By:
- Joseph R

## Oxygen Supply

- Have oxygen tank.
- Enough oxygen to support 500 people for six months.
- Brought up in liquid form.
- Heated up to gas form.
- Giant greenhouse with trees and plants.
- Two vents, one pushing oxygen into colony, and one sucking out the carbon dioxide.
- Another two vents doing the exact opposite of the vents in the colony.

## Food Service 

- Basic food supplies will be brought up.
- After the gravity is activated, the robots will plant wheat, rye, and corn.
- People will bring up additional crops when they come up to the colony.
- There will also be chickens, pigs, goats, and later, cows.
- (Use oxygen given off by the crops to breathe).

- Corn

- Wheat

- Rye

**Notes:**
Of the rye used each year in the United States:
about 50 percent is used as livestock feed; 
about 20 percent is consumed as food; 
about 19 percent is used as seed; 
about 10 percent is allocated for industrial uses; and 
a fraction of 1 percent is exported. 

## Energy Supply

- Use fuel cells.
- The cells will be run off of hydrogen.
- The hydrogen will come from, wind, solar, and geothermal power.
- Use the fuel cells to supply heat, oxygen, and distilled water.

- Geothermal Power

- Wind Power

- Solar Power

## Water Distribution 

- Bring liquid water to Mars with people.
- Polar ice caps in the North and South Poles.
- Most water in caps is frozen carbon dioxide.
- There might be some ice underground, or there may even be liquid water.
- Once we have enough water, we can create an artificial lake.
- Using water filters, we can recycle waste water.

- Polar Ice Caps on Mars

- Water!!

- Carbon Dioxide

- Remember to Recycle!!

## Transportation

- Inside colony people will ride bikes and walk.
- Outside of colony, we will use rovers, hovercrafts, and small transportation pods to transport us to Mars’s moon Dactyl.
- The rovers must be able to have room to store cargo.

- Hovercraft

- Rovers

- Dactyl

- Iron

- Gold

- Platinum

- Silver

## Protection 

- The dome will be made of plexus- glass.
- It will be reinforced with iron bars.
- The sides of the colony will be made of aluminum.
- This will be reinforced with iron bars and plywood.
- There will be a shatter-proof layer of plexus- glass to protect the top from meteors.

- Plexus- glass

- Aluminum

- Plywood

- Iron bars

## Detailed Fuel Cell
# Presentation: 944319

## Lab-developed Software& Export Control

- Sarah Maynard, Customs Office
- (505) 665-2194, maynard@lanl.gov
-                    -and-
- Tom McDonald, Classification Office
- (505) 667-5012, mcdonald@lanl.gov

## Presentation Outline

- History
- Software Release Authorization Process
- Future On-line Software Review Development
- Code Export Process
- Approval Forms and Checklists

## History

- 1989 Guide to Export
- Software & electronic dissemination
- Plant visits by foreign nationals
- 1997 IG Inquiry
- 1998 Formalized Process
- 2000 LIR & Mandatory Training

## Software Issues for LANL

- Is Software Classified or UCNI?
- Does Software have Commercial Value?
- Patentability
- Copyright
- License
- Software Developed with Collaborators?
- Proprietary Rights and Ownership

## ECCN Determination

- 			     Classification makes ECCN		Classification sends a
- 			       determination from specifications or		copy of determination to
- 			       meeting with code owner 		Customs Team
- Code Owner sends
- Software Release Form	      				Classification asks Customs
- To Classification	     Classification is unsure of ECCN		Team to apply for ECCN			     or jurisdiction		     	or CJ
- Form contains					Customs Team applies
- Line management 					WAITS
- Signature that the					Sends copy of the
- Code is publicly					determination to
- Available						Classification and files for
- 							future export request

## Current Procedure:Author Completes Forms

- Software Release Form
- Copyright Disclosure Form
- Software Distribution Request Form
- Participant/Company Licensing Questionnaire
- Energy Science & Technology Software Center (ESTSC) Form
- U.S. Copyright Office Registration Form

## Online Procedure Under Development

- Author Completes a Single On-line Form
- Form goes to Appropriate Offices for Review and Approval
- Management
- Classification Office (S-7)
- Customs Office (BUS-6)
- Industrial Business Development Office

## Code Export Process

- Customs Team 		Custom Team		Customs Team
- Receives request on		Retrieves ECCN		Checks TDOs
- Export Approval Form
- 							Customs Team checks
- 							entity if unknown 				If no license exception
- 				applies or entity is bad
- 				Customs Team applies
- 				for a license
- 							Customs Team notes license						number and conditions or 							license exception on							Export Approval Form
- 							& sends to Requester
- 							Code is exported
# Presentation: 171278

## Speed Forum	

- Washington DC
- June 2005
- T.Hicks MSHA

- The word “speeding” is, perhaps inaccurate and can be a misleading term; “excessive speed” (for existing conditions) would seem to be a more accurate term
- “Speed too fast for conditions” appears to be a major safety issue

- There is a need to define the problems and the terms being discussed
- Understanding what “speed” is or means is a national problem
- Regulatory, posted, prevailing, advisory, 85th %-tile, design, relative, average, travel, operating, prima facie, statutory, and other adjectives are used to describe “speed”

- The world of speed limits appears to have divided itself into three (3A) parts:
- (1) Special areas/zones, such as residential, school and work zones
- (2) Arterial and collector roads, and urban expressways and freeways where the speed limits are set on the basis of studies

- (3) Rural freeways and expressways where speed limits are more likely to be statutorily established
# Presentation: 796847

## Natural Gas: Summer 2005

- Steve Harvey
- FERC
- July 25, 2005

**Federal Energy Regulatory Commission**

## Gas prices for the past year(Daily NYMEX prices for the prompt month)

- Gas prices for the past year(Daily NYMEX prices for the prompt month)

**Price ($/MMBtu)**

## Gas prices for the last year have remained near recent highs

- Henry Hub Price ($/MMBtu)

## Gas prices are not related to storage inventory levels alone

## Clearly gas prices have some relationship to oil prices too

## Gas prices do appear related to oil and storage inventories

- Gas prices do appear related to oil *and* storage inventories

**2005**

**1999-2003**

**2004**

## Other effects may relate to financial trading

- Other effects may relate to financial trading

## Financial trading prices appear to be driving physical prices at times

**Monthly Index for December = $7.78**

**NYMEX Settlement for December = $7.976**

## Hard to measure the extent of financial trading

- Open Interest  (thousand contracts)

## Financial trading activity appears to be increasing in 2004
# Presentation: 708024

## DOM MB Gain

- Gerald Przybylski
- March 12, 2007
- LBNL

## Handy Single Photoelectron Pulse Model

- Chosen for its similarity to an actual PMT pulse, a triangle pulse 15ns wide at the base by 5mV high across Z, the termination resistance.

- 10ns

- -5mV

- 0

- 0

- 20ns

## A Single Photoelectron Model

- (15ns)(5mV)
-         2
- Where Z is the termination resistance,
- and G is the PMT gain
- G = 37.5 pVs / ( Z **.** 1.602E-19 )
-     = 37.5 pVs / 43Ω / 1.602E-19 Coulomb
-     = 5.44E6

- =  37.5 pVs  = Z G (1.602E-19)

- x 2.66

- x 3

- x 3

## `

- The integral under the curve is92 x 1mV x 10ns = 920 pVs

- 920/37.5 = 24.53 x 3 x 2.66 = 23.9
# Presentation: 326916

## Supply Chains and Private Sector Dynamics

## Major trends in freight logistics
Supply chains basics
Implications for planning 

- Supply chains basics
- Implications for planning

- Agenda

## 
Productivity

Congestion

Input cost factors

- Productivity
- Congestion
- Input cost factors

- Trends in Trucking

## Trends in Trucking - and More

## Trends in Rail Freight

- Intermodal growth
- Capacity constraint
- Capacity allocation

## Trends in Waterborne Freight

-  Mega-ships
-  All-water routes
-  Transloading
-  Short-sea
-   prospects

## Trends in Pipelines

-  Weather risks
-  Ethanol
-   conversion

## Trends in Air Cargo

- Ground substitution
- Global carriers

## Trends in Logistics

**  **Visibility
-   Globalization
-   Fast Cycle Logistics

## Globalization: Trade Percent of US GDP

## Supply Chain Basics

## Traditional Logistics

- _METHOD OF CONTROL_

- _SUPPLY CHAIN_

## Fast Cycle Logistics

- _METHOD OF CONTROL_

- _SUPPLY CHAIN_

## Supply Chain Management

- Transforms non-valued added activities into strategic management functions
- “Just-in-time” transit replaces inventory
- Reliability surpasses cost as most important transportation consideration

## Advanced Manufacturing

- Reliable and timely
- Higher value shipments
- Just-in-time manufacturing
- Multi-modal, truck dominant

## Natural Resource Manufacturing

- Bulky goods
- Low damage, low cost
- Less emphasis on speed
- Rail and barge dependent

## Non-Durable Manufacturing

- Heavy or high cube
- Moderate to high value
- Moderate to high speed
- Local ends of long supply chains
- Truck dominant

## Service Industries

- Accessibility
- Reliability
- Smaller, more frequent trips
- Truck and express package dependent

## Global Supply Chain:  High Tech

## Global Supply Chain: Retail Office

## Regional Chain: Consumer Beverages

## High Service Chain: Health Care

- Implications for Planning

## Planning Considerations

- The Supply Chain = the Business Enterprise
- Business competitiveness depends on transportation performance
- Chains are sensitive to time and disruption
- Chains cross jurisdictions
- Needs vary by chain

## Freight Planning and Economic Competitiveness

-  Travel and vehicle operating costs              LOS
-  Inventory carrying costs              Reliability
-  Asset utilization costs              Land use
-  Access to markets                Multi-jurisdictional
-   planning

## Fuse information with technology
Demand high performance transportation system
Impacts supply chains and business models

- Demand high performance transportation system
- Impacts supply chains and business models

- Businesses Compete on Logistics Costs
# Presentation: 226348

## TESTING STRONG-FIELD GRAVITY

**University of Arizona**

**DIMITRIOS PSALTIS**

**WITH BLACK HOLES**

## TESTING GRAVITY

## Slide 3

## TESTS OF GENERAL RELATIVITY

**TESTS ****OF GENERAL RELATIVITY**

**Psaltis 2006**

**       ****Eclipse**
**Hulse-Taylor**

**Mercury**

**Moon**

**GP-B**

## The Equivalence Principle Has Been Tested             to a Very High Degree

**The Equivalence Principle Has Been Tested ****            to a Very High Degree**

**Will 2006**

## Extending Einstein’s Equation

**Extending Einstein’s Equation**

## We can only rely on phenomenological spacetimes

**We can only rely on phenomenological spacetimes**

**e.g., measure coefficients of multipole expansions of the metric**

**Ryan 1995; Collins & Hughes 2004**

## How about Quantum Phenomena around Black Holes?

**How about Quantum Phenomena around Black Holes?**

## XTE J1118+480

**Mirabel et al. 2001**

**XTE J1118+480**

## XTE J1118+480

**XTE J1118+480**

**Constraining Large Extra Dimensions**

**Psaltis 2006**

## Constraining Large Extra Dimensions

## The Good News

**We have a parameter-free solution to an astrophysical problem!**
# Presentation: 183521

## g4beamline study of Si PIN diodeBill Ashmanskas2008-03-06

- I didn't *start* until I got Camille's reminder email yesterday ...
- Nevertheless, I got something useful out of the simulation!
- So g4beamline is a pretty handy tool

## Mean E is 4 keV out of 660 keV.  But in fact only 1% interact at all, and the ones that

- Mean E is 4 keV out of 660 keV.  But in fact only 1% interact at all, and the ones that
- do interact seem to lose most of their energy.  (Note that I measured energy lost by photon,
- not necessarily energy gained by silicon.)  Not sure why a handful of E > 660 keV.

- preview of punchline
- ...  stop here if you're bored

## just google “g4beamline”

## simple ASCII description of problem to be simulated

## run the program ...

## check that geometry is not crazy (1000 evts shown here)

## Slide 7

## Slide 8

## Ran 100K tracks in 2 minutes on a 6 year old PC (1.8 GHz P4)

## I chose ASCII output; you could choose ntuple, root, etc.

- note that this is the output of a test run (1000 tracks), not the final run

## match upstream & downstream particles; output consolidated data (e.g. E in keV)

- match upstream & downstream particles; output consolidated data (e.g. E in keV)

## Mean E is 4 keV out of 660 keV.  But in fact only 1% interact at all, and the ones that

- Mean E is 4 keV out of 660 keV.  But in fact only 1% interact at all, and the ones that
- do interact seem to lose most of their energy.  (Note that I measured energy lost by photon,
- not necessarily energy gained by silicon.)  Not sure why a handful of E > 660 keV.

## 660 keV photons from Cs137 source
S1223-01 Hamamatsu silicon PIN diode
From datasheet:
Window  5.9mm, 1.3mm thick, borosilicate glass
Effective active area 3.6mm x 3.6mm
Egap  1.12eV at 25°C
From elsewhere
316.5m intrinsic region thickness

- S1223-01 Hamamatsu silicon PIN diode
- From datasheet:
- Window  5.9mm, 1.3mm thick, borosilicate glass
- Effective active area 3.6mm x 3.6mm
- Egap  1.12eV at 25°C
- From elsewhere
- 316.5m intrinsic region thickness
# Presentation: 306750

## white poplarPopulus  alba  L.Other common names: silver poplar, silverleaf poplar. 

**CULTURALLY:**
- This poplar was brought to the North American continent in 1748 from Europe.  It quickly escaped and spread rapidly.  It now grows in 43 of the continental United States.  It spreads primarily by root suckers rather than by seed.
- A yellow dye was made from the bark.
- The Iroquois made a decoction from the branches and washed themselves with it as an anti-love remedy.
**MEDICINALLY:**
- The bark contains salicin, a glycoside which changes into salicylic acid (aspirin) in the digestive track.  It was used primarily in treating muscle or joint aches, fevers, rheumatism, gout, debility and menstrual cramps.

- Photo courtesy of:  Herman, D.E. et al. 1996. *North Dakota tree handbook*. USDA NRCS ND State Soil Conservation Committee; NDSU Extension and Western Area Power Admin., Bismarck, ND. Courtesy of _[ND State Soil Conservation Committee](http://www.ag.ndsu.nodak.edu/aginfo/trees/handbook.htm)_. Provided by _[USDA NRCS ND State Office](http://www.nd.nrcs.usda.gov/)_. ND. This image is not copyrighted and may be freely used for any purpose. Please credit the artist, original publication if applicable, and the USDA-NRCS PLANTS Database. The following format is suggested and will be appreciated:  USDA-NRCS PLANTS Database / **Herman, D.E. et al. 1996. *****North Dakota tree handbook*****. USDA NRCS ND State Soil Conservation Committee; NDSU Extension and Western Area Power Admin., Bismarck, ND.**

- Slide developed by Pat Broyles, Soil Conservationist, Manhattan, KS. PMC.  USDA is an equal opportunity employer.
# Presentation: 520194

## More Energy Efficient Commercial Buildings

- Mark Halverson
- Pacific Northwest National Laboratory

## Commercial End-Uses

**Notes:**
Taken from DOE’s Annual Energy Outlook 2004
The “Other” end-use in the AEO includes service station equipment, automated teller machines, telecommunications equipment, medical equipment, pumps, emergency electric generators, combined heat and power, manufacturing, and cooking (distillate).  Of these, only pumps are typically covered in codes through motor requirements. 

## Commercial End Uses Covered in Energy Codes

**Notes:**
Merely combining the space cooling, space heating, lighting, service water heating, and ventilation into the “code end uses” category generates a chart like this.  

## DOE’s Goal

- Reduce all slices of the pie to as low a level as technical feasible and economically justified with the ultimate goal of achieving Zero Energy Commercial Buildings

**Notes:**
Reference discussion of Phoebe at Plenary Session on “120%” buildings that generate more energy than they  consume.  Or see later session on Zero Energy Homes

## Code Nomenclature I

- Prescriptive
- 	Simple lookup requirements for building elements
- System Tradeoff
- 	Simple tradeoffs between prescriptive requirements within a building system
- Performance
- 	Tradeoffs between prescriptive requirements across the entire building

## Code Nomenclature II

- Above Code
- 		Improving the existing requirements of the code, but 	staying within the traditional focus of the code
- Beyond Code
- 		Adding entirely new concepts to the code

## Commercial Taxonomy

|  | Prescriptive | System Tradeoff | Performance |
| --- | --- | --- | --- |
| Code | IECC Chapter 8
ASHRAE 90.1 | COMcheckEZ
ENVSTD | IECC 806
ASHRAE ECB
(simulations) |
| Above Code | 
ASHRAE AEG
NBI Benchmark |  | Energy Star (actual bills) |
| Beyond Code |  |  | LEED
(simulations) |

**Notes:**
The parentheses suggest that there is a third taxonomy structure that could be applied that differentiates simulated results from actual measured performance data.  

## DOE’s Interest

- Energy savings
- 30% over ASHRAE Standard 90.1-1999
- Simple and prescriptive
- Easy and inexpensive
- Informative
- Lots of “how to” information
- Source of future code change proposals

## Our Speakers Today Are

- Don Colliver - ASHRAE
- 	Advanced Energy Guide for Small Offices
- AKA SP 102 and AEG
- Jeff Johnson - New Buildings Institute
- 	Advanced Buildings -Energy Benchmark for High Performance Buildings
- AKA E-Benchmark and Benchmark