# Presentation: 188827

## National Drug Abuse Treatment

- <date/time>

**National Drug Abuse Treatment**
**Clinical Trials Network**

**Research Training Directors Meeting**
**November 3, 2006**
**Harold I Perl, PhD**
- Center for the Clinical Trials Network
- NIDA/NIH/DHHS

**Notes:**
NIDA, NIH, DHHS

## Research           Practice

- <date/time>

**Research****           ****Practice**

***Bridging***
***the***
***Gap***

***NIDA Clinical Trials Network***
***CTN***

## Mission of CTN

**Mission of CTN**

***To Improve Drug Abuse Treatment***
***Throughout the Nation...***
***Using ******SCIENCE****** as the Vehicle***

## The CTN Enterprise

- <date/time>

**A unique partnership among:**
**NIDA ...**
**	**** **
**	****treatment researchers ...**
**	****	**
**community-based service providers**

**The CTN Enterprise**

## CTN Objectives

- <date/time>

- Study behavioral, pharmacological, and integrated treatment interventions to
***determine*** ***effectiveness*** across a broad range of ***community-based*** ***settings*** and
***diversified*** ***patient*** ***populations***
- Ensure the ***transfer*** ***of*** ***research*** ***results*** to physicians, clinicians, providers, and patients

**CTN Objectives**

## CTN On-the-Ground

**State with Community Treatment Program (CTP)**

**CTN On-the-Ground**

## The CTN Trials (1999 – 2006)

**The CTN Trials (1999 – 2006)**

**Medical Interventions:    9**
**Behavior Interventions: 11**
**HIV/HCV Interventions:  4**
**Others:  3**

## Opiate Dependence
0003: Buprenorphine/Naloxone Stabilization and Taper Schedules
0010: Buprenorphine/Naloxone for Adolescents
Nicotine Dependence
0009: Smoking Cessation
Ethnic Minorities
0021: MET for Spanish Speakers

_**Opiate Dependence**_
**0003:** Buprenorphine/Naloxone Stabilization and Taper Schedules
**0010:** Buprenorphine/Naloxone for Adolescents
_**Nicotine Dependence**_
**0009:** Smoking Cessation
_**Ethnic Minorities**_
**0021:** MET for Spanish Speakers

_**Women**_
**0013:** MET for Pregnant Women
**0015:** Seeking Safety Intervention for Trauma and Substance Use
_**Families**_
**0014:**** **BSFT for Adolescents
_**HIV/HCV**_
**0017:**** **HIV/HCV Intervention
**0018:**** **HIV Risk Reduction for Men
**0019:**** **HIV Risk Reduction for Women

## CTN Trials in Progress

- Buprenorphine/Naloxone for prescription opioid analgesic dependence
- Osmotic-Release Methylphenidate for smoking cessation in ADHD adults
- Osmotic-Release Methylphenidate for treating ADHD and SA disorders in adolescents
- Effects of Buprenorphine/Naloxone vs. Methadone on liver function

## Research Utilization  

**Research Utilization  **

***Adoption of Buprenorphine***

**Source: Roman et al ; Presented 2006**

***Adoption of Motivation Incentives***

## Making Use of CTN Infrastructure 

**Making Use of CTN Infrastructure **

**  ****Independent RPGs using CTN as a platform**
*  ***Ancillary studies connected to a CTN trial **
**  ****Career Development awards**
**  ****Minority Researcher supplements**

** ****Treatment and Services Research**

**Research Training**

**  ****Pre-doctoral and Post-doctoral Fellowships**
** “****Junior” Investigators affiliated with CTN**
** ****T32 training programs **

## Pre-Doctoral Training
T32, F31, F30, R03
Post-Doctoral Training
T32, F32
Career Development Awards
K01, K02, K05, K08, K12, K22, K23, K24, K25 
Research Supplements to Promote Diversity in Health-Related Research  

- <date/time>

- Pre-Doctoral Training
***T32****, F31, F30, R03*
- Post-Doctoral Training
***T32****, F32*
- Career Development Awards
*K01, K02, K05, K08, K12, K22, K23, K24, K25*
- Research Supplements to Promote Diversity in Health-Related Research

**Training Opportunities in CTN**

## CTN Data for Secondary Analyses

- www.ctndatashare.org

**DOWNLOAD DATA FILES**

## www.nida.nih.gov/CTN/Index.htm

**www.nida.nih.gov/CTN/Index.htm**