# Presentation: 409443

## DIVISION OF NEUROSCIENCE AND 

**DIVISION OF NEUROSCIENCE AND **
**BEHAVIORAL RESEARCH**
**(DNBR)**

**NATIONAL ADVISORY COUNCIL ON**
**DRUG ABUSE**
**FEBRUARY 14, 2001**

_**NIDA**_
_**NATIONAL  INSTITUTE**_
_**ON DRUG ABUSE**_

## Reorganization of

**Reorganization of**
**DNBR**

**WHY?**

_**NIDA**_
_**NATIONAL INSTITUTE**_
_**ON DRUG ABUSE**_

## OVERALL:

**    ****More efficiently** **identify the cause**
**    ****and consequence of substance **
**    ****abuse in order to improve treatment**

**OVERALL:**

_**NIDA**_
_**NATIONAL INSTITUTE**_
_**ON DRUG ABUSE**_

**    **

**Director: Dr. Glen Hanson**
**Deputy Director for Program: Dr. David Shurtleff**
**Deputy Director for Science and Technology**
**   ****Development: Dr. Karen Skinner**
**Associate Director for Neuroscience**
**   ****Coordination: Dr. Roger Brown**
**Special Assistant and Training Coordinator:**
**   ****Dr. Charles Sharp**
**Deputy to Training Coordinator: Beth Babecki**

_**NIDA**_
_**NATIONAL INSTITUTE**_
_**ON DRUG ABUSE**_

**OFFICE OF DNBR DIRECTOR**

##  Organized into 5 branches 

-  **Organized into 5 branches **
-    **to reflect contemporary strategies**
**   ****and technologies**

** ****Areas of interest assigned as                 **
**   ****they relate to basic science   **
**   ****issues**

_**NIDA**_
_**NATIONAL INSTITUTE**_
_**ON DRUG ABUSE**_

##  Behavioral and Cognitive Science    	 Research Branch

** **_**Behavioral and Cognitive Science    **_**	**** **_**Research Branch**_

**Antecedent and consequent behavioral and**
**cognitive factors to drug abuse, electro-**
**physiological and systems processes and**
**computational modeling**

_**NIDA**_
_**NATIONAL INSTITUTE**_
_**ON DRUG ABUSE**_

**Acting Chief: Dr. Minda Lynch**
**Program Officers: Drs. Paul Schnur, Susan Volman & **
**                                ****Cora Lee Wetherington**

##  Chemistry and Physiological

** **_**Chemistry and Physiological**_
**    **_**Systems Research Branch**_

**Analytical methods, basic chemistry, **
**pharmacokinetics, perinatal effects, AIDS,**
**neuroimmune function, and peripheral**
**physiological systems**

_**NIDA**_
_**NATIONAL INSTITUTE**_
_**ON DRUG ABUSE**_

**Chief: Dr. Rao Rapaka**
**Program Officers: Dr.  Paul Hillary, Pushpa Thadani **
**                                 ****and Hari Singh**

##  Pharmacology, Integrative and

-  _**Pharmacology, Integrative and**_
-     _**Cellular Neurobiology Research**_
**    **_**Branch**_

**Neuroendocrine modulation, cellular neuro-**
**pharmacology, mechanisms of neurotrans-**
**mission, neuropasticity, neurotoxicity and**
**neuroprotection**

_**NIDA**_
_**NATIONAL INSTITUTE **_
_**ON DRUG ABUSE**_

**Acting Chief: Dr. Nancy Pilotte**
**Program Officers: Drs. Jerry Frankenheim and Geraline Lin**

##  Genetics and Molecular Neuro-

-  _**Genetics and Molecular Neuro-**_
-     _**biology Research Branch**_

**Genotypic and phenotypic factors, trans-**
**criptional regulation, applied proteomics**
**and basic cellular mechanisms**

_**NIDA**_
_**NATIONAL INSTITUTE**_
_**ON DRUG ABUSE**_

**Acting Chief: Dr. Jonathan Pollock**
**Program Officers: Dr. Rebekah Rasooly,**
**	****	****        ****Two positions to be filled**

## Translational Research Branch

**imaging, technology development, **
**clinical application of basic science,**
**cooperative interest with other divisions,**
**institutes and private sector**

_**Translational Research Branch**_

_**NIDA**_
_**NATIONAL INSTITUTE**_
_**ON DRUG ABUSE**_

_***Special interest:***_** *****nicotine-related issues, ***
***pain, and frontal lobe mechanisms***

## Translational Research Branch

_**Translational Research Branch**_

_**NIDA**_
_**NATIONAL INSTITUTE**_
_**ON DRUG ABUSE**_

## MAJOR OBJECTIVES:

**MAJOR OBJECTIVES:**

_**NIDA**_
_**NATIONAL INSTITUTE **_
_**ON DRUG ABUSE**_

##  Factors contributing to addiction transition

** ****Factors contributing to**** *****addiction transition***

_**NIDA**_
_**NATIONAL INSTITUTE**_
_**ON DRUG ABUSE**_

*** ******Neural development and***** its role in **
***	******vulnerability***** to addiction**

*** ******Genetics of vulnerability***

*** ******Basic cognitive***** & *****behavioral processes***** **
**	****related to drug abuse**

** ****Use of *****emerging technologies***** (e.g. gene**
**	**** ****arrays)to study the addiction**

*** ******Proteomics***** to appreciate the role of proteins in the **
** ****	****addiction process**

*** ******Translation***

##           INITIATIVES

**          **_**INITIATIVES**_

_**NIDA**_
_**NATIONAL INSTITUTE**_
_**ON DRUG ABUSE**_

*** *****RFA initiatives**

***-Insertional Mutagenesis***

***-Cutting Edge***

***-GHB Initiative***

***- Computational Supplement***

***- Transition to Addiction***

*** *****Anticipated initiatives**

***- Cognition and Frontal Lobes in Addiction***

***- Protein Trafficking and Drugs of Abuse***

***- Nicotine Workgroup (Translational Model)***

## QUESTIONS?

_**NIDA**_
_**NATIONAL INSTITUTE**_
_**ON DRUG ABUSE**_

**QUESTIONS?**