# Presentation: 100442

## NBN Data Element MappingRetrospective Piece

- Warren Kibbe, Rhett Sutphin, Andrew Winter, Linning Liao, Julie Zhu
- Northwestern University

## Inter-Prostate SPORE Biomarker Study (IPBS)

- Develop an interoperability system to allow data and specimen sharing among Prostate SPORE programs
- Interoperability system must be caBIG compatible at the “silver” level by time of pilot system delivery
- Utilize caBIG tools wherever possible (e.g. caTISSUE, caTIES, CAE)
- Assist Prostate SPOREs in connecting site-specific databases to the interoperability system

## What we have

- Home-grown system: Prostate SPORE Clinical Database
- Designed for the clinical (non-pathology) data in the SPORE
- Home-grown system: Tissuebank
- Designed and used specifically for the Prostate SPORE and Breast SPORE tissue needs
- Home-grown system: NOTIS
- Designed for managing protocol life cycle and patient consenting, accrual and calendar
- Freezerworks
- Used for all activity in Pathology Core

## Mapping of IPBS elements to Home grown system

- Majority maps to Prostate SPORE Clinical Database
- Some maps to Tissuebank
- Some maps to NOTIS

## NBN to CAE

- Age
- Race

|  | In CAE? |
| --- | --- |
| clinical/pathology |  |
| PSA | No |
| clinical stage | Yes |
| biopsy Gleason | Yes |
| pathology Gleason | Yes |
| surgical margins | Yes |
| seminal vesicle involvement | Yes |
| organ confined | No |
| lymph node metastases | Yes |
| neoadjuvant treatment | No |
| [neoadjuvant dose - XRT] | No |
| [neoadjuvant hormone type] | No |
| [neoadjuvant dose - hormone] | No |
| [neoadjuvant duration] | No |
| adjuvant treatment | No |
| [adjuvant dose - XRT] | No |
| [adjuvant hormone type] | No |
| [adjuvant dose - hormone] | No |
| [adjuvant duration] | No |
| Date of diagnosis | Yes
 |
| outcomes |  |
| recurrence | No |
| recurrence date | No |
| last follow-up status | No |
| last follow-up date | No |

**Notes:**
6/22 IPBS fields mapped to CAE

## NBN to caTissue Core

|  | In caTissue Core? |
| --- | --- |
| Age | Domain:Participant |
| Race | Domain:Participant |

**Notes:**
There are 19 NBN fields that correspond to data kept in the NU pspore database.  2 of these will map onto the caTISSUE Core OM.

Age, Race 
    -> domain:Participant
date of diagnosis 
    -> None.  SpecimenCollectionGroup contains clinicalDiagnosis but no date.

All clinical/pathology fields
    -> None.  caTISSUE contains no way to record associated clinical data or observations.  ClinicalReport appears to be intended to act as a reference to an outside pathology report.

All outcomes fields
    -> None.  caTISSUE contains no way to record associated clinical data or observations.

## IPBS to CTOM

- All elements map to CTOM (with some creativity)
- Age -> Participant.
- Race-> Participant.  Need to map into raceCode and ethnicGroupCode.
- Date of diagnosis -> Activity and Diagnosis.
- PSA -> Procedure (possibly SpecimenCollection) and ClinicalResult
- Clinical stage -> CancerStage
- Biopsy Gleason -> Procedure (possibly SpecimenCollection) and ClinicalResult (or Histopathology)
- Pathology Gleason  -> Surgery and Histopathology
- Surgical margins  -> Histopathology
- Seminal vesicle involvement -> ClinicalResult
- Organ confined -> ClinicalResult
- Lymph node metastases -> MetastasisSite
- Neoadjuvant treatment, dose XRT; adjuvant treatment, dose XRT -> SubstanceAdministration (for hormone) or Radiation
- Recurrence, recurrence date -> Observation
- Last followup status & date -> Activity and ClinicalResult

**Notes:**
There are 19 NBN fields that correspond to data kept in the NU pspore database.  2 of these will map onto the caTISSUE Core OM.

Age, Race 
    -> domain:Participant
date of diagnosis 
    -> None.  SpecimenCollectionGroup contains clinicalDiagnosis but no date.

All clinical/pathology fields
    -> None.  caTISSUE contains no way to record associated clinical data or observations.  ClinicalReport appears to be intended to act as a reference to an outside pathology report.

All outcomes fields
    -> None.  caTISSUE contains no way to record associated clinical data or observations.