# Presentation: 657508

## Biomedical Engineering and Biomedical Informatics Program

**Barbara Beckerman**
**Modeling and Simulation Group**
**Computational Sciences and Engineering Division**

## Biomedical engineering and biomedical informatics research at ORNL

**Biokinetic and biotransport modeling**
**Three-dimensional organ and tissue ****modeling using CT or other imagery ****(pulmonary, arterial, musculoskeletal)**
**Prediction of outcomes based ****on biomedical models**
**Knowledge discovery and intelligent ****agents for data mining and analysis**
**Integration of models at multiple temporal and spatial scales**
**Computer environments ****(data repositories, search tools, visualization, etc.) in support of ****biomedical and medical applications**

## ORNL HotBox integrates all the DARPA Virtual Soldier windows

- ORNL HotBox integrates all the DARPA Virtual Soldier windows

**HotBox interface**

**Anatomical ontology:**
**Foundational model ****of anatomy**

**Predicted location****of wound**

**SCIRun Net**

**Physiology ****display**

**Geometry window ****with thorax model**

-    Beckerman_Biomed_0611

## Biomedical applications for thenext-generation Internet (NIH/NLM)*

***Funded by National Library of Medicine–NLM-N01-LM-0-1-3512 and LM-0018-01 (1998–2003); ****PI–Mitch Schnall, University of Pennsylvania;  Co-PI/Technical Director–B. Beckerman, Oak Ridge**

- Biomedical applications for thenext-generation Internet (NIH/NLM)*

- NationalDigital MammographyArchive

## Predictive multi-scale modeling

- Model for predictingvascular disease

**Spatial modeling****of cell migration**
**Kinetic modeling****of biochemicals**
**Result: A multi-scale hybrid continuous-discrete predictive model for tissue pathology**

**Atherosclerotic artery**

**Matrix metalloproteinases (MMPs)**

## Metrics for tissue anatomy
Temporal measurement of lumenal diameter 
Imaging of vascular wall perturbations after injury due to balloon angioplasty
Biological modeling and simulation environments (cellular, tissue, and multi-scale kinetics models)
Discrete event simulationsto predict resultsof vascular wall injury

**Dorsal view**

**Ventral view**

**Metrics for tissue anatomy**
**Temporal measurement ****of lumenal diameter **
**Imaging of vascular wall perturbations after injury ****due to balloon angioplasty**
**Biological modeling and simulation environments (cellular, tissue, and multi-scale kinetics models)**
**Discrete event simulations****to predict results****of vascular wall injury**

**Thoracic and neck vasculature seen in the microCAT scanner using the vascular contrast agent Fenestra VC**
**(Images courtesy of J. Wall,****University of Tennessee Medical Center)**

- Computational modelingfor vascular systems:Collaboration with the UT Medical Center

- Mammalian models

- Computational models

## Orthopedics research at UTK/ORNL:Dynamic and kinematic models of motion for knees, hips, and spine

- Orthopedics research at UTK/ORNL:Dynamic and kinematic models of motion for knees, hips, and spine

**Cervical Spine**
**Dynamic Model**

## Computational modeling of pre- and post-operative lumbar spine system

**In vivo imaging and analysis of lumbar ****spine system ****(Komistek, Mahfouz)**
**Finite-element mesh models of the spine (Nukala)**
**Constitutive modeling ****of intervertebral discs (Nukala)**

**Two vertebrae and a disc**

## Seizalert on PDA:2005 R&D 100 award*

- Seizalert on PDA:2005 R&D 100 award*

**Non-linear analysis ****approach predicts onset ****of epileptic seizure**
**Implemented in software ****on a PDA or wearable ****device to alert wearer ****to occurrence of seizure**
**Protected by five patents ****and two pending**
**Licensed to Hercules Development Corporation**

***Hively, Protopopescu, Munro, Kruse (2005)**

-    Beckerman_Biomed_0611

## ORNL solves biomedical problems

**Convert CT slice data ****to finite-element mesh**
**Abdominal aneurysms**
**Prediction of wounds**
**Data repositories**
**Parallel computations**
**Computational tools ****for toxicants**
**Agent technologies**
**Ontologies and informatics**

-    Beckerman_Biomed_0611

## Contacts

- Barbara Beckerman
**Program Manager, Biomedical Engineering**
**Computational Sciences and Engineering Division**
**(865) 576-2681**
**beckermanbg@ornl.gov**

- Brian Worley
**Director, Computational Sciences and Engineering Division**
**(865) 574-4837**
**worleyba@ornl.gov**

- Richard Ward
**Senior Research Scientist**
**Computational Sciences and Engineering Division**
**(865) 574-5449**
**wardrc@ornl.gov**

-    Beckerman_Biomed_0611

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