BEE-spoke-data/govdocs1-by-extension huggingface dataset:
# Presentation: 833978

## Bob Hollingsworth

- Executive Director, ESGR

## Employer Support of the Guard and Reserve

- OSD staff activity chartered in 1972
- DoD Directive 1250.1
- ESGR is the primary DoD office for all matters concerning employer support of the National Guard and Reserve, as well as for employer relations initiatives relative to employee participation in the Reserve components
- 3,000 volunteers (10/05) and 56 staff

**Notes:**
Volunteers largely retired military. 

Effort underway to recruit more diverse volunteer base.

2002 paradigm shift from primarily RC outreach to primarily employer outreach.

DoD Directive 1250.1
The NCESGR is the primary DoD office for all matters concerning employer support of the National Guard and Reserve, as well as for employer relations initiatives relative to employee participation in the Reserve components.
The secretaries of the military departments shall provide initial and recurring USERRA and employer relations training to all RC members.

## Mission

- To gain and maintain support from all public and private employers for the men and women of the National Guard and Reserve

**Notes:**
DoD Directive 1250.1
The NCESGR is the primary DoD office for all matters concerning employer support of the National Guard and Reserve, as well as for employer relations initiatives relative to employee participation in the Reserve components.

ESGR customers are the employer community and RC members, and ESGR stakeholders are the uniformed services, OSD, and ESGR volunteers.

Total employer population is approx 7.4 mil; of which an estimated 250,000 employ RC members.

## Scope of Effort

**Media Relations**

- *US Census, 2001
- ** Estimate based on CEI data

**Direct Marketing**

**Strategic Partners**

**115k Known unique employers of RC members****

**4mil members**

**7.4 mil total employer population***

**Notes:**
Census numbers from North American Industry Classification System, 2001. Does not include self-employed.

RC employer number highly subjective. CEI data is critical in assessing total number of RC employers, industry/size/demographic representation

All numbers fluid as organizations are created / go out of business

## 5-Star Employer Program

## 10 Reasons to Hire RC Members

- Leadership
- Professionalism
- Responsibility
- Mission-Critical Skills
- Physical Conditioning
- “Can-Do” Attitude
- Calm Under Fire
- First-Class Image
- On Time, All the Time
- Global Perspective

## ESGR Employer OutreachThe Way Ahead

- Availability of targeted data
- Scope of effort
- Strategic partnerships
# Presentation: 319643

## Enhanced Observed Time Difference (E-OTD)

- Beth Frasco, Head of Radio Planning
- Aerial Communications

## About Aerial

- PCS A & B block Licensee
- GSM technology
- License for 28 million pops in 6 MTA’s
- Minneapolis, Columbus, Kansas City, Pittsburgh, Houston & Tampa/Orlando

## E-OTD Overview

- Triangulation based technique
- Handset based solution
- Does _not_ use GPS in handset
- ALI methodology provided for in GSM
- Enhancement to handset software required

## E-OTD - Extension of GSM

- GSM network is unsynchronized.
- Mobiles must synchronize with each BTS.
- Base stations regularly emit a synchronization burst.
- Mobiles monitor synchronization bursts of serving and all neighbor cells.
- Mobiles “Pre-Synchronize” with all neighbors to be prepared for handover.
- E-OTD builds on and extends this functionality.

## E-OTD - How it Works

-  Mobile listens to bursts sent from neighboring BTSs
-  Mobile records burst arrival times
-  Position is triangulated from:
- Coordinates of BTSs
- Arrival time of burst from each BTS
- Timing differences between BTSs

## E-OTD - Site Implementation

**LMU Must Measure the Transmission Time of the Burst**

**LMU**

## E-OTD - Handset Implementation

- No Change to Existing Antenna Structure

- No Change to Existing DSP or RF Hardware

- Software Modification Required to Enhance Existing Measurements Process

**Mobile Must Precisely Measure the Arrival Time of Burst**

## Potential E-OTD Vendors

- Motorola
- Nokia
- Nortel
- Siemens
- Alcatel
- Cambridge Positions Systems (CPS)
# Presentation: 481858

## Aspen’07New Physics at the Electroweak Scale and New Signals at Hadron Colliders 

## The Race Course

- 22 Attendees Participated in the Race!

## The Ambiance

## The Race

## Best Absolute Times

## The Winner

- Carsten Hof
- Course Time/Score
- Yellow 17.70/21.07   Silver
- Green 18.06/21.86   Silver
- Silver Medal

## The  Gold

- Beate Block
- Green 23.90/61.27
- Yellow 24.10/64.84
- Gold Medal

## Beate Block

## The Silver

- Karen Grahn
- Green 24.22/63.43
- Green 22.19/49.73
- Yellow 22.51/53.97
- Green 22.48/51.69
- Yellow 22.84/56.22
- Silver Medal

## The Team

## The Gone Broke Award

- Ben Kilminster

- Mike Kirby

## CMS: the First Collisions

- A 170 lb person traveling at 20 mph
- Mv2/2 = 4x103 J = 2.5 x 1022 eV = 2.5 x 1013 GeV = 450 GeV x 5.5 x 1010 p – one LHC bunch at the injection energy
- Rainer Wallny: “How I was hit by a bunch!”

## The Broken Pole Award

- t = -1 minute

- Watch This!

## The Yugo Award

## The Best Bronze Award
# Presentation: 426887

## The Jackson Employment CenterPima County, Arizona

- The Jackson Employment CenterPima County, Arizona

- Steven Nelson
- Mary Pat Sullivan

## Slide 2

## Interlocking Systems

- Local Continuum of Care
- WIA One Stop Career System
- Runaway and Homeless Youth
- Offender Discharge Planning
- Behavioral Health Networks
- Veterans’ Employment Services
- Interfaith Collaborative Networks

## INTERLOCKING SYSTEMS

## Something for Everyone

| Chronic Homeless | Advent | HUD/SHP |
| --- | --- | --- |
| Disabled | Bridges | HUD/SHP |
| Adults | CASA | HUD/SHP |
| Families | CASA for Families | HUD/SHP |
| Youth | La Casita | HUD/SHP |
| Veterans | HVRP | DOL/VETS |
| Ex-Offenders | New Chance | HUD/SHP |

## Who are the experts in a given area?
How can we add value?
How can we share resources?
How can we align plans?

- How can we add value?
- How can we share resources?
- How can we align plans?

## Individual Service Strategy

- Plan services according to individual needs
- Use network of partners to expand the menu of service options
- Define steps to reach the goal of employment and housing

## Employability Skills

- 2-week vocational assessment workshop
- Teach labor-market savvy
- Provide a foundation for employment
- Assess motivation to work and maintain transitional housing

## Jackson Employment Center Program TotalsFY 2002-2003 FY 2003-2004FY 2004-2005 FY 2005-2006

|  | 2002-2003 | 2003-2004 | 2004-2005 | 2005-2006 |
| --- | --- | --- | --- | --- |
| Clients graduated | 254 | 312 | 271 | 286 |
| Number placed | 189 | 213 | 196 | 200 |
| Placement rate | 75% | 69% | 72% | 70% |
| Average wage | $8.38 | $9.18 | $9.43 | $9.33 |
| 6 mo. retention | 74% | 87% | 82% | 69% |
# Presentation: 827274

**Follow-Up Material for the GM Meeting on Liquidity Tools and Strategy**
***May 13, 2003***

***Draft***

***Attachment  B***

##  Remaining  Borrowing Authority 

- Recently BPA received $700 million in additional borrowing authority.
- Based on estimated capital spending forecast, BPA will run out of borrowing authority in:
- 5 years (FY2008) **With** 2003 debt optimization payment of $315M to Treasury and then no further Debt Optimization program.
- 4 years  (FY2007) **Without** the 2003 debt optimization payment to Treasury and no further Debt Optimization program.
- 3 years (FY2006) **Without** the 2003 debt optimization payment to Treasury and not making $170M of scheduled amortization, and no further Debt Optimization program.

***Draft***

***Updated***

- w:\kgs\99rtcase\FERC_12-99.ppt

##  Remaining  Borrowing Authority 

***New***

** ****Remaining **** ****Borrowing**** ****Authority**** **

- w:\kgs\99rtcase\FERC_12-99.ppt

## Estimated BPA Total Annual Interest Expense Savings Due to Debt Optimization

- At its peak, Debt Optimization allows BPA to recognize about $42 million per year in interest savings.
- Savings to date have been minimal because savings ramp-up over time.
- If the program was stopped, BPA would not realize approximately $340 million in interest savings.

**Estimated BPA Total Annual Interest Expense Savings**** Due to Debt Optimization**

***Draft***

***Updated***

- w:\kgs\99rtcase\FERC_12-99.ppt

## Estimated BPA Total Annual Interest Expense Savings Due to Debt Optimization

***Draft***

***New***

- w:\kgs\99rtcase\FERC_12-99.ppt

## Priority of Payments 

***New***

**Priority of Payments**

**I.**
**II.**
**III.**

**Net Billing Credits**
**Other**
**BPA**
**Payments**
**Treasury**
**Payments**

**Net**
**Billing Credits**

**BPA Fund**

**BPA’s O&M cash expenses including**
**cash payments provided for by Net Billing Agreements**

**BPA Fund Net Proceeds**

** **Corps & Bureau, LSRC Comp. Plan O&M
- CSRS Payment
- Bond Interest
- Appropriations Interest
- Bond Principal
- Appropriations Principal
- Irrigation Assistance payments
- Judgment Fund

- w:\kgs\99rtcase\FERC_12-99.ppt
# Presentation: 253719

## CIVIL AIR PATROL CADET PROGRAMSPARENTS’ INTRODUCTION

## Introduction

*Video*

**Notes:**
See capchannel.com for a selection of cadet-related videos.

## Program Elements

- 	Leadership  		    Aerospace  		      Fitness

- 		         Character			Activities

## Adult Supervision

- Fingerprinting & FBI screening
- CAP avoids 1-on-1 contact whenever possible
- All activities are supervised by adults

## Cadet Activities

- Weekly squadron meetings	Time, place	Attendance policy
- Weekend activities
- Summer activities

## Flying

- Safety first
- Licensed pilots
- No cost to cadets

## Advancement

- Cadets learn, study, test
- Earn promotions, ribbons, awards
- Experienced cadets serve in leadership roles
- Role of Cadet Great Start

## Bright Futures

- College scholarships
- Service academies
- ROTC
- USAF E-3 benefit
- Responsible citizens

**Eric Boe**
- NASA Astronaut & Former Cadet

**Nicole Malachowski**
- Air Force Thunderbird & Former Cadet

**Integrity       Service      Excellence      Respect**

## Membership

- Eligibility
- Annual dues	Local dues	Activity fees
- Uniforms	Cadet Uniform Program	Other sources	Obtaining insignia	Grooming standards
- Cadet Member Kit
- Tax deductions

## Partnering with Parents

- Open, on-going communication	Local websites, email, newsletters	Leaders’ contact information
- If you have a concern, let us know
- Adults are welcome to join CAP	Cadet Sponsor Members	CAP Officers
- Parents’ Committee
- Parents’ Home Page: cap.gov/parents

## Final Thought

**“****I never knew how much ****I could accomplish ****until I joined CAP.”**
# Presentation: 516446

## Job Hazards Analysis

-  Information Technology Division
- Group Leads Overview
- March 19, 2008

## What is the JHA?

- JHA is a work authorization that describes
- The tasks that comprise the work
- The hazards associated with those tasks
- The controls that mitigate the identified hazards
- Answers the request posed in the field:
*“**How do you know how to do your job safely?”*
- Applies to all Work and all Workers at LBNL
- Does NOT apply to UCB space
- Addresses new policy and audit requirements
- PUB-3000, Chapter 32 (LBNL Health and Safety Manual, JHA Chapter)
- Addresses 10CFR851 (DOE requirements on top of OSHA that could impose financial penalties for oversights)
- The JHA will replace the JHQ but they will run parallel until June 2008

## How does the JHA process work?

- Worker enters JHA software and generates preliminary JHA through subscription to a Work Group and/or by answering questions
- Worker meets with Supervisor/Work Lead to review preliminary JHA, make changes to reflect actual conditions or local requirements (a facilitator will assist for the initial roll out)
- Supervisor/Work Lead and Worker sign document
- The completed JHA will generate what training is required by each employee

## Lab wide Timeline for the JHA Program

- Late CY 2006-early CY 2007: Discussion, focus group, presentations to DSCs, DLs, SRC
- March 2007: PUB-3000, Ch. 32 adopted
- September 2007: Pilot Program complete
- October 2007: Lessons Learned from Pilot
- Oct-Dec 2007: Software implementation
- January-May 2008: Develop Group JHAs
- JHQ and JHA will run simultaneously
- June-September 2008: Individual JHAs
- Mandated Goal is 75% of LBNL has JHAs by 9/30/2008

## IT Timeline for the JHA

- January 2008:  Kick-off
- February 2008: Identify Work Groups
- March 2008:  Develop tasks, hazards and controls for Work Groups
- May 2008:  Everyone completes their JHA to replace JHQ
- Communication ongoing
- Use the JHQ until notified of change

## What is a “Work Group”?

**Work Group**: A set of individuals having common administrative structure, performing similar tasks having similar hazards and controls.  The administrative structure does not always equal the Work Group
- Very flexible definition, adapt to your own business needs
- Has an owner responsible for keeping tasks, hazards and controls current
- One person can belong to multiple Work Groups

## IT Work Groups & Leads

- 	Computer User
- 			Lead:  Ann Tomaselli
- 			Backup: Tammy Welcome
- 	Computer Support Field Operations
- 			Lead:  Charlie Verboom
- 			Backup: Gary Jung
- 	Networking and Telecomm Field Operations
- 			Lead: Ed Ritenour
- 			Backup: Ted Sopher
- 	Computer Room Operations
- 			Lead:  Ed Ritenour
- 			Backup: David Edgar
- 	Library and Archives Operations
- 			Lead: Jane Tierney
- 			Backup:  Rosemary Lowden
- April – Meet to write tasks, hazards and controls
# Presentation: 715810

## Session 60

- Post Collections Portfolio Management Tips and Techniques
- David S. Hammond Jr.

## Measurements

- “What you reward gets measured”

- In our business what we measure gets rewarded. With much of our destiny tied to the efforts of external entities it has become more and more critical that we set in place the right measures and rewards.

## External Partners

- Private Collection Agencies (PCA’s)
- Technology Partners
- Consultants

## Collection Balance

- HERA
- PCA Performance
- PCA Communications
- Report Analysis
- Peer Groups

## Technical Slide

- We appreciate your feedback and comments.
- We can be reached at:
- Phone: 202-377-3122
- Fax: 202-275-0543
- Email: David.Hammond@ed.gov
# Presentation: 271581

## If WE Build it, 			They Will Come!

- Gretchen Ann Morris, CISSP
- NASA IT Security Awareness and Training Center (RS Information Sys.)

## Build What?

- An Information Systems Security Course (TRAINING) that is...
- Role-based
- NIST 800-16 based
- Web-based
- Select role and level of difficulty
- Receive a list of links to appropriate training pages

## WE?

- FISSEA members
- Who could do a better job?
- Who knows our field and our audiences more?
- Did we come here ONLY to have fun and learn?
- Think about volunteering some of your time and effort to help build a training product we all can use

## Why?

- OMB, FISMA, NIST, and Us
- The National Strategy to Protect Cyberspace
- Generating training that covers all job roles and can be used by all is one of the best ways to help protect our country’s cyberspace and our agency systems.
- Do the right thing!
- NIST 800-16 is a GREAT map – all of the hard work and effort the authors put into it should not go to waste.

## Who is They (the audience)?

- Everyone within our Agencies that has access to Government Information Systems
- Anyone else who may use Information Systems at work or at home

## How?

- Coordination
- Support
- TEAMWORK

## Coordination

- I will
- Answer questions
- Coordinate
- Put the pieces together
- Give a copy of the final product (on CD) to any FISSEA member who requests it

## Support

- Challenge the new FISSEA board to consider adding this task to the Board’s Top Priority list
- Get their buy-in and help
- Documentation
- Writing guide

## TEAMWORK

- Writers
- 46 cells times 3 levels = 138 cells of training
- 1 person = way too much work
- 46 people = could write all 3 levels of one cell each
- Technical Editors = 46 (edit 3 cells each)
- Grammatical Editors = 46 (edit 3 cells each)
- Or any other combination we can come up with

## What do you think?

- The Good, the Bad, the Ugly...
- Would you sign up to...
- Write the training for a particular cell - maybe one of your areas of expertise (one or more levels)
- Be a technical or grammatical editor
- Receive status reports on the project and possibly volunteer to help later

- Personal contact information available in the conference attendance sheet.
# Presentation: 667399

## The “Aging”Today and Tomorrow 

**Policy Committee – White House Conference on Aging -- July 14, 2004**

## Number of Persons 65+ and 85+:  1900 – 2050

- [Numbers in Millions]

## Percent 65+ and 85+: 1900 – 2050

## Slide 4

## Percent Veterans in the 65+ Population

**27.5% of Americans aged 65+ were Veterans in 2000**

## Slide 6

## Racial & Ethnic Composition 65+

- 2002

- 2050

- *AoA estimate

## Living Arrangements of Men & Women 65+ - 2002

- Men

- Women

## Slide 9

## Slide 10

## Slide 11

## Slide 12

## Income: 2002

**$33,802 median for 11.7 million family households 65+ **

**Income: 2002**

## Slide 14

## Median Net Worth by Age

## Slide 16

## Slide 17

## Slide 18

## Slide 19

## Slide 20

## Functional Limitations Among Medicare Beneficiaries: 2002

## Slide 22

## Slide 23

## Slide 24

## Slide 25

## Slide 26

## Slide 27

## Slide 28

## Slide 29
# Presentation: 722392

## Librarians and the EHR: Envisioning the Future

- Sara Pimental
- Kaiser Permanente
- Senior Consultant
- Clinical Library

## Kaiser Permanente

- Founded in 1945
- 14,000 Physicians
- 40,000  Nurses
- 160,000 employees

## Kaiser Permanente 

- 32 Medical Centers
- 421 Medical Office Buildings
- 9 states and Washington DC
- 8.7 million members

## Clinical Library

- Deliver evidence based information to the point of care
- Available to all Kaiser staff
- Combines Kaiser written material and third party

## HealthConnect

- Ambulatory phase completed in 2008
- 36.5 million office visits
- Inpatient targeted for 2009-2010

## Context Senstive Search

- Eliminates the need to re-do a query in Clinical Library
- Uses ICD-9 codes, age and gender in the EHR
- Translates into a search to Clinical Library

## Slide 8

## Is it All About Metadata??	 

## Slide 10

## Convergent Medical Terminology

- KP-specific set of names and concepts
- Comprehensive coding scheme used to document all aspects of a patient visit and treatments
- Hybrid of industry-standard language and KP-specific usage

## Other Opportunities???

## Diagnostic Tools

- Missed diagnosis accounts for almost 40% of Kaiser’s malpractice claims
- Heuristics - short cuts or rules of thumb
- 44% of our physicians report that difficult to diagnose cases comprises 6-15% of their caseload

- Isabel
- VisualDX
- First Consult
- Clin-eguide
- BMJ Point of Care
- Dynamed

**Sara Pimental MLIS AHIP**
- Senior Consultant
- Clinical Library, Kaiser Permanente
- sara.pimental@kp.org
- Office: 510.271.2360
- Cell 510.292.5015

## Slide 16
# Presentation: 522337

## The Changing Arctic Climate:

**Historical**** ****Observations and**
**a New Paradox**
- James Overland
- NOAA/Pacific Marine Environmental Laboratory, Seattle, WA USA

## OUTLINE

-  Instrumental (historical) Context
-  External Forcing Mechanisms
-  Present State of the Arctic

## Arctic Change Detection websitehttp://www.arctic.noaa.gov/detect/

## 20th Century Zonal Mean Surface Air Temperature Anomalies (Nov. – Mar.)

## Spring  Anomalies

- Surface air temperature (Apr.)

- Sea level pressure (Mar.-Apr.)

- contour interval of 1 hPa

## External Climate Forcing

## Conceptual Model of Arctic Warming 

- Conceptual Model of Arctic Warming

**w**

## Projections of February Surface Temperature Change2010-2029 minus 1980-1999

- Projections of February Surface Temperature Change2010-2029 minus 1980-1999

- http://zubov.atmos.iuc.edu/ACIA

- CCC

- NCAR CSM

- GFDL

- HADLEY

- ECHAM

- 5 Model Composite

## Arctic Hemispheric Connection

- Mt. Pinatubo

## Main Arctic Change Indicators

- Arctic Change Detection website -- http://www.arctic.noaa.gov/detect/

## Arctic Oscillation (AO) Index

- Thompson and Wallace, 1998 *Geo. Res. Let**.*

**EOF**** 1****      Sea Level Pressure**

- Stratosphere Geopotential Height

## Composite 200 hPa Temp Anomalies

- 1980-1989

- 1990-1998

- 1999-2004

## Surface Air temperature Anomalies

- Tromso
- Dikson
- Verjojansk
- Schmidta
- Barrow
- Resolute
- Egedesminde

## Arctic Changes

- Permafrost degradation on the Tanana Flats
- Jorgenson et al., 2001, Climatic Change

- Sea Ice

- Sept 2003

##  Conditioning of Sea Icein the Beaufort and Chukchi Seas1998 – 2001

- Ignatius Rigor

**Sep 1998**

**Sep 2001**

**Sep 2000**

**Sep 1999**

**93**

**93**

**93**

**93**

**97**

**97**

**97**

**96**

**96**

**99**

**96**

**99**

**97**

## Changes in the Arctic Ecosystem

- Road Open Period for Tundra Travel
- In Alaska North Slope

**Changes in the Arctic Ecosystem**

- Barents Sea Cod

- East BeringSea Pollock

## Walrus herd in the Chukchi Sea– June 2002

- [M. Webber-USFWS]

- Schematic of food web in the northern Bering and Chukchi Seas
- [Grebmeier and Dunton 2000]

- Clam food in walrus stomachs

- [photos courtesy G. Sheffield]

## SUMMARY

- The present Arctic change is unique in the record of instrumental measurements (1880 -2004).
- Arctic changes are coupled to and amplify Global Changes.
- However ...
- Over last four years many indicators show strong persistence, decoupled from atmospheric circulation
- Local Arctic Processes are more important (and faster) than previously recognized.
# Presentation: 170049

## REGIONAL BIOCONTAINMENT LABORATORIES CONSTRUCTION PROGRAMRFA-AI-04-032

**July 27, 2004**
**National Institute of Allergy and Infectious Diseases**
**Division of Microbiology and Infectious Diseases**
**Office of Biodefense Research Affairs**

## TODAY’S AGENDA

** **
**	****Welcome ****	****	****	****	****	****Ms. Nancy Boyd**
**	****NIAID Role in the National Biodefense Agenda****	****Ms. Deborah Katz**
**	****Scientific Program Overview****	****	****	****Dr. Alicia Dombroski**
**	****Facility Program Overview****	****	****	****	****Ms. Nancy Boyd**
**	****Scientific Review Issues/Concerns****	****	****	****Dr. Peter Jackson**
**	****Grants Management Issues/Concerns****	****	****Ms. Mary Kirker**
**-- 10 Minute Break --**
**Questions and Answers**
** **
**	****Notes:**
**	****	********  ****Please be sure to sign in at the entrance to the conference room**
**	****	********  ****Note cards – Please turn in at the speaker’s table before break**
**	****	********  ****A list of attendees for today’s meeting will be available on the **
**	****	****    ****NIAID Biodefense web site**
# Presentation: 688024

## RHESSI Investigations of the Neupert Effect in Solar Flares

- Brian R. Dennis
- AAS/SPD Meeting
- 6 June 2002

## The Neupert Effect

- The time integral of the hard X-ray emission closely matches the temporal variation of the soft X-ray emission.
- Implies that accelerated electrons that produce the hard X-rays also heat the plasma that produces the soft X-rays.

## SXR:HXR Ratio vs. Flare SizeA. Veronig et al. A&A, in press (2002)

## RHESSI Contribution

- RHESSI observes both the soft X-rays (down to ~3 keV) and the hard X-rays with the same detectors.
- RHESSI also provides 2 arcsecond imaging capability in both soft and hard X-rays.
- RHESSI’s temporal resolution for images is 2 s for a complete set of spatial Fourier components.
- The spatially integrated time resolution is limited only by counting statistics.

## RHESSI’s Limitations

- Suffers pulse pile up when the rates exceed ~10,000 counts per detector per second.
- Shutters moved into FOV when dead time reaches ~10%. Limits lower energy response below ~10 keV.
- K-escape photons contaminate low energy counts with higher energy emission.

## RHESSI/GOES Comparison

## 10 April 2002

- GOES 10  1 - 8 Å

- Time derivative GOES 1 - 8 Å

## RHESSI Images

- 6 – 12 keV

- 25 - 50 keV

- 12 – 25 keV

- 50 – 100 keV

- 10 April 200219:02:34 – 19:03:03 UT

## X1.5 Flare on 21 April 20022650 + 0043 0151 0238 GO8 5 XRA 1-8A X1.5 6.0E-01 9906 

## X1.5 Flare on 21 April 2002

## 21 April 2002

- GOES  1 - 8 Å

- Time derivative GOES 1 - 8 Å

## X1.5 Flare on 21 April 2002

## Start of X1.5 Flare on 21 April 2002TRACE images at 195 Å, RHESSI 12 – 25 keV contours

- 00:42:50 – 00:43:10 UT

- 00:48:54 – 00:49:14 UT

## Start of X1.5 Flare on 21 April 2002TRACE images at 195 Å, RHESSI 12 – 25 keV contours

## X1.5 Flare on 21 April 2002TRACE 195Å images and RHESSI contours at times of hard X-ray peaks	12-25 keV 	50 – 100 keV

- 01:15:43 – 01:16:03 UT

- 01:23:27 – 01:23:47 UT

## Conclusions

- Neupert Effect is alive and well.
- Fraction of flare energy in accelerated electrons
- Increases with flare size on average
- Decreases with time during 21 April X flare
- Additional heating mechanism is required
# Presentation: 821162

## Pixel Overview

- Santa Cruz
- July 2003

## Critical Path Schedule

- Note in calendar not fiscal years

## Major Milestone Changes Since ETC03

- Failure of FE-I2 and MCC-I2 runs => 4-5 month delay in start of bare module production, assuming FE-I3 used only.
- Finalization of contracts with bump vendors
- 600 + 600 modules in 18 months
- 2-hit system requires 1154 modules in detector, perhaps 1500 to be started => more than 18 months from start of bare module production until end.

## Impact on U.S. Milestones

- Depends on what we assume about module delivery to the U.S.

- Disk modules

## Details of Bare Modules

- May be slower ramp

- May be faster at end

## Milestones

## Possibilities to Speed Up

- Use FE-I2.1 chips => this gains 3 months in bare module start
- Can’t tell at this time if this is technically acceptable BUT must plan for it.
- Assuming FE-I2.1 yields about 1200 chips on bare modules, this is 75 modules ie. one disk if we are lucky.
- Ask the bump bonders to go faster
- In progress for AMS
- I assume will be asked of IZM
- Difficult to really push this until FE-I3 wafers available and we know production can start ie. not until early 2004.

## Near-term Implications

- Critical path items must be tightly organized, priority in resources
- In the US this is: FE-I->wafer probing-> thinning/dicing -> die sort -> module assembly -> sector mounting
- There will considerable political opposition to allocate most of the bare modules to disk production.
- Apart from appeals(our money runs out), the way to proceed is to be ready to go into production assembly and testing of modules and to mount them on sectors.

## Other Implications

- Assuming LHC schedule does not slip, the time available for surface integration and commissioning of the disks, barrels, service panels, PP1.... will be compressed.
- I believe this means we have to rethink the surface assembly sequence, but not today or tomorrow. Will be subject of October internal workshop at CERN.
- I anticipate that the end result will be to maintain or increase the pressure on delivering mechanics items and optoboards on our current schedule.

## ETC03 Estimates and Installation MC

- Contingency 35% or about $1.8M

## ETC04 

- I have started work on ETC04 database but need input from this meeting and later.
- My plan is to get input from this meeting and complete preliminary version by end of month.
- Feedback to you.
- Final version, as usual, will be after October 1 when we know carryover from FY03.
# Presentation: 739161

## CHANGING NOW FOR THE FUTURE

- FLORIDA FISH AND WILDLIFE CONSERVATION COMMISSION
- DIVISION OF MARINE FISHERIES MANAGEMENT

## FLORIDIANS ASK FOR A NEW FISH AND WILDLIFE AGENCY

- 1999 CONSTITUTIONAL REFERENDUM
- COMBINED WILDLIFE, FRESHWATER, SALTWATER RESPONSIBILITIES
- MARINE FISHERIES RULEMAKING CHANGES
- COMMISSION REPLACES LEGISLATIVE/EXECUTIVE OVERSIGHT
- WORK WITH GOVERNOR AND LEGISLATURE ON BUDGET/LICENSING

## AGENCY STRATEGIC REDESIGN

- WE MERGED BUT DIDN’T INTEGRATE
- FOCUS ON BETTER COMMUNICATIONS
- STAKEHOLDER INVOLVEMENT
- ALTERNATIVES TO RULEMAKING
- SCIENCE-BASED DECISIONS
- PROACTION, NOT REACTION

## CHARTING A COURSE FOR MARINE FISHERIES IN FLORIDA

- WORKING WITH STAKEHOLDERS
- DEVELOP A VISION FOR FLORIDA’S FISHERIES
- RECOGNIZE COMPETING INTERESTS AND FIND RIGHT BALANCE
- RECOGNIZE INCREASING USE AND DIMINISHING HABITAT/QUALITY

## MAJOR THEMES

- ALLOCATION OF RESOURCES
- ACCESS TO RESOURCES
- PROTECTION OF RESOURCES
- ENFORCEMENT
- REGULATORY RESTRICTIONS
- HABITAT, HABITAT, HABITAT
- SUPPORTING COOPERATIVE MANAGEMENT

## RECREATIONAL FISHING IS HUGE

- TOTAL ECONOMIC IMPACT
- $5,537,000,000
- 59,000 JOBS
- SALTWATER LICENSE SALES INCREASING
- BOAT REGISTRATIONS INCREASING
- FLORIDA’S POPULATION INCREASING

## TOTAL SALTWATER PARTICIPANTS

**RESIDENT AND NON-RESIDENT**

**1994-95 THRU 2003/04**

- (PAID LICENSE HOLDERS ONLY)

- Res 12 Month & Res 10 Day

- Res Combo (HF, FC)

- Gold Sportsman

- Five Yr - New & Cont'd.

- Non-Res 12 Month

- Non-Res Short Term

- Sweaver

- Revised 01/05

- s:graphs - 10yrs.xls

## Landings Trends

## Slide 9

## FUTURE CHALLENGES

- SUSTAINING RESOURCES FOR HARVEST
- ENSURING QUALITY HABITAT
- MANAGING DEMAND
- ALLOCATING HARVEST
- INCREASING QUALITY OF RECREATION
- MAINTAINING FOOD FISH PRODUCTION
- GARNERING PUBLIC SUPPORT
# Presentation: 777270

## EDI Offsetting

- Austin Financial Center
- Dallas Agency Forum
- August 15-16, 2007

## Payment Types Affected

- Corporate Trade Exchange (CTX)
- Generated from EDI 820 input
- Generated from Flat File input
- CCD+/PPD+
- Generated from EDI 820 input

## Changes

- 820
- If BPR 17 is VEN – eligible for offset
- If BPR 17 is blank, then BPR 18 must be ‘ZZ’ and BPR 19 will contain ‘YES” if eligible for offset or ‘NOT’ if NOT eligible for offset
- Flat File
- Field 4 of Payment Record (Line Code) must contain code for type (‘V’ – vendor or ‘M’ for Miscellaneous
- Field 12 of Payment Record must contain Offset Eligibility Code (‘Y’ or ‘N’)

## More Info

- Scheduled for implementation in December 2007
- Currently contacting all impacted agencies to assess their readiness
- Formats online at _[http://fms.treas.gov/ctx/formats.html](http://fms.treas.gov/ctx/formats.html)_
- Questions/Concerns – (512) 342-7359
# Presentation: 785146

## In the Eye of the Storm

- Jake Fey
- Tacoma Power

- BPA Conference
- September 25, 2001

## Strategies to Overcome the Tornado

**Create public awareness of the seriousness of the storm**
**Empower customers to act **
**Create permanent shelters for future storms**

## Create Public Awareness

**Advertising **
**Newspaper Ads – “Testimonial”(Jan 28 – April 16)**
**Newspaper Ads – “Honor Roll” (Apr 22 – Jun 11)**
**Pierce Transit/Bus Ads (Feb 14 – Aug 11)**
**Joint-Utility Radio & TV Ads (Mar)**
**Cinema Ads (Jun – Sep)**
**City Scapes, PSA, City Line (Click! & City TV)**
**Public Events**
**Ad Launch, Food Bank, School Honor Roll, Key Accounts Meeting**

## Empowering Customers

- Residential
- Power Parties (185)
- Conservation Kits Giveaways (6,000)
- CFL Bulbs Rebates & Giveaways (57,913)
- Business / Institutional
- Vending Misers (1,882)
- Single-zone Thermostats (309)
- Energy Audits (154)

## Permanent Shelter

**Energy Code Adoption**
**Energy Curtailment Ordinance**
**Integrated Resource Plan**
**36 Megawatts/10 years **
**$100 million **
**Conservation Ramp-up**

## Conservation Saves Tacoma Millions
# Presentation: 541023

## Moving Toward a New Day:  On the Horizon of Ohio’s Mental Health Care May 4, 2006Columbus, OH

**Center for Mental Health Services**

- Moving Toward a New Day:  On the Horizon of Ohio’s Mental Health Care ***May 4, 2006*****Columbus, OH**

## Ohio’s 

**Ohio’s **
**Mental Health Care System**

**Category Grades**
- Infrastructure		    B
- Information Access	    A
- Services		    B
- Recovery Supports	    B

- Source: A Report on America’s Health Care
- System for Serious Mental Illnesses, National
- Alliance for Mental Illness (2006)

- 2

## 3

## Federal Partners Workgroup

**Department of Health**_**               **_**and Human Services**
**     **AoA		NIH/NIDA
-      ACF		NIH/NIMH
-      AHRQ	HHS/OS
-      CDC		 - ASPE
-      CMS		 - OCR
-      HRSA	 - OD
-      IHS		 - OPHS
- 		 SAMHSA

**Other Partners**
- Department of Agriculture
- Department of Education
- Department of Defense
- Department of Housing and Urban Development
- Department of Justice
- Department of Labor
- Department of Transportation
- Department of Veterans Affairs
- Equal Employment Opportunity Commission
- Social Security Administration

- 4

## Common Characteristics of Successful Transformation SIG Applicants

- Governors who are active and invested in the process and dynamic leaders in pertinent government agencies.
- Collaboration across agencies, with local collaboratives, and with the private sector.

- 6

## Ohio’s Population

- Total population
-  ≈ 11.5 million

- Source: http://quickfacts.census.gov

- Persons under 18 years old
- 25 percent

- Persons 65 years old and older
- 13 percent

## An existing network of partners who can help to 

- promote and protect the mental health of Ohioans.

- 7

## Every day, more than 52 million students attend more than 114,000 schools in the United States. 

- 8

## Common Characteristics of Successful Transformation SIG Applicants (continued)

- Ability to build on existing strengths.
- Consumers and families very active in and central to the process.

- 9

## Let Your Vision of Transformation Take Flight!

- 10

## “We have always held to the hope, the belief, the conviction that there is a better life, a better world, beyond the horizon.” 

- —Franklin Delano Roosevelt
- U.S. President, 1933–1945

- 11
# Presentation: 735558

## Montana’s Statewide Montana’s 511 Traveler    Information System	

**T3 Webinar**
**January 9, 2008**

## Overview

**Montana’s Traveler Information System**
**511 in Montana**
**Benefits**
**Partnerships**
**Usage/User Satisfaction**
**Lessons Learned**
**Future Enhancements**

## Traveler Information in Montana

## Montana’s 511 System

**Deployed January 8, 2003**
**9****th**** Statewide system **
**13****th**** overall system**
**When deployed – largest geographical area with smallest population**

- Photo courtesy of  AHMCT

## Montana’s 511 System

**System Content **
**Winter road conditions**
**Construction project information**
**Road closures / major delays / chain requirements**
**Route specific weather forecast**
**Glacier National Park Information**
**Alert capability**
**Comment line**

## Montana’s 511 System, cont’d

**Choosing Meridian**
**Existing database**
**Integrated forecast**
**Cost benefit from shared infrastructure**
**How is the information gathered?**
**How often is the information updated?**

## Who Benefits From Deploying      511 in Montana?		

**MDT **
**Traveling public**
**Other agencies**

## 511 Partnerships/Potential 

**Glacier National Park**
**Department of Justice**
**National Weather Service**
**Yellowstone National Park**
**Travel Montana**
**Montana Highway Patrol**

## Statistics

**Increase in call volumes more than threefold**
**Peak months are November through March**
**More than 1.5 million calls to date**
**System has accommodated more than 35,000 calls a day with no busy signals or disconnects**

## 511 Awareness

-  **WTI’s Customer Survey – March 2003**
**58% heard of 511 **
**29% used 511**
**12% of those aware found out thru TAP**
**MDT’s Customer Survey – October 2004**
**51.1% heard of 511**
**46.8% heard of 511 and had used it**

## Customer Feedback

**Comment Line**
**National Progress Report**
**Continued Education and Public Awareness **
**Identify system flaws or weaknesses and improve**

## Lessons Learned

**Detailed contract**
**Create system requirements**
**Mileposts vs. landmark reference**
**Put a timestamp on 511 information**
**Create a test plan**

## Future Enhancements

**511**
**Inclusion of all secondary routes**
**Yellowstone National Park **
**Tourism Information**
**Transit**
**TMC**
**Microwave **
**AVL**

**Notes:**

TMC
 - provide 24/7 coverage (monitor devices, conditions, and weather) 
 - statewide communications improvements – microwave radio system enhancements
 - improved emergency response and incident management (coordination with MHP, ES)

AVL
Track equipment, material tracking, reduction or tort claims
TMC monitoring
As the system continues to evolve with customer feedback and changing technologies, it’s critical that MDT maintain a long-term vision for the system to ensure its viability from a statewide and regional perspective. 

**Any Questions?**

## Contact Information

**Brandi Hamilton**
- Traveler Information Program Manager
- Maintenance Division
- (406) 444-0468
- _[brhamilton@mt.gov](mailto:brhamilton@mt.gov)_
# Presentation: 004628

## MI60 Quad Offsets For NuMI

- Quad offsets and dipole currents for NuMI design
- Existing MI closed orbits and dipole currents
- Installation of Lambertsons with present dipole settings

- Dave Johnson

## Main Injector orbits with momentum offsets

- Dave Johnson

## Orbits with only quad offsets

- Q606   1.5 mm
- Q608	2.154 mm
- Q610	1.62 mm
- Q612	1.95 mm

- All quads are offset to
- the inside of the ring

- Here positive-x is to the inside of the ring

- inside

- outside

- Dave Johnson

## Closed orbit with kicker counter-wave and maximum Lambertson bump

- H602	-15.53 A
- H604	-0.84 A
- H606	-1.75 A
- H608	+16.7 A
- H610	+20.41 A
- H612	+19.04 A

- Corrector currents

- Dave Johnson

## Maximum circulating and extraction orbits

- Extraction positions match Design Report at LAM60C
- X = 18.071 mm  X’ = -0.773 mr

- Dave Johnson

## Current MI 120 GeV/c flattop orbit w and w/o H604:3 bump

- Dave Johnson

## Flattop Corrector settings

- Note corrector currents

- Ratio of currents look
- like a closed bump

- Dave Johnson

## Current 120 GeV/c corrector currents

- Dave Johnson

## Desired positions and flattop orbit

- Current MI52 desired positions

- Current MI52 orbit

- Dave Johnson

## H604:3 Bump

- Bump inside

- Bump outside*

- LM604^

- H602

- HP604

- RMS current 10.3 A

- 28 Amps on H602

- *Amplitude used in design

- ^Loss present before kicker fires
- maybe during bunch rotation

- Dave Johnson

## Closed orbit with reduced Lambertson bump

- H606	+7.2 A
- H608	+7.27 A
- H610	+10.24 A
- H612	+8.32 A

- Corrector currents^

- HP608*  15 mm
- HP610*  15 mm

- *Bump amplitude  greater than current MI52 desired positions

- ^These currents added to
- existing corrector currents

- Dave Johnson

## Beam Profiles thru LAM60A

- Reduced bump

- Design

- Extracted

- Dave Johnson

## Beam Profiles thru Q608

- Reduced bump

- Design

- Dave Johnson

## Beam Profiles thru LAM61C

- Dave Johnson

## Bottom line

- Based upon the presented quad offsets, current corrector currents, reduced bump amplitude- there should not be a problem in steering around the NuMI Lambertsons.
- Based upon the corrector offsets, the MI Dept should investigate the machine alignment by smoothing the 120 GeV/c closed orbit by quad moves and reducing the corrector offsets in the 60 to 30 region of the ring.
- The MI Dept should understand the loss seen at Q604 at pbar production extraction time when the beam is bumped to the outside.
- The MI Dept should assure that there is plenty of loss monitor coverage for the new Lambertsons

- Dave Johnson
# Presentation: 454816

## A Study of Variability in Tropical Tropospheric Water Vapor

- _[http://](http://tes.jpl.nasa.gov/PUBLICATIONS/documents.html)__[tes.jpl.nasa.gov](http://tes.jpl.nasa.gov/PUBLICATIONS/documents.html)_

- A51A-0054

- _VALIDATION_: Is the level of agreement between TES and in-situ H2O limited by spatial variability of H2O?

- _Fig. 1._ 22 Jan 2006 comparison between TES and WB-57F in-situ water from take-off, 10oN, 84oW (60-km, 1-hour proximity) shows large differences at 500-700 hPa.

- _Fig. 2._ 25 Jan 2006 comparison between TES and CFH in-situ water near San Cristobal, Galapagos Is., 0.9oS, 89.6oW (59-km, 1-hour proximity), shows better agreement at most pressure levels.  Aqua MODIS Vis. Image courtesy of David Tobin.

- _TROPICAL VARIABILITY:_

- _Fig. 3._ Left: TES transect on 25 Jan 2006 shows relatively little H2O variability.  Center: differences between CFH and TES are within TES error and within 1 st. dev. of TES retrieval variability except at 500-750 hPa.  Right: fractional difference for 17 TES retrievals within 200 km of CFH.  Differences up to 30% are seen between two TES retrievals 12 km apart and closest to CFH (red and green lines).

- _Fig. 4._ H2O curtain plots from two TES transects (22 Jan and 1 Feb 2006) show more spatial variability than 25 Jan 2006, particularly in the middle troposphere.
# Presentation: 711024

## Weather Briefing

- June 24 10:00 CDT

## Verification

- Yesterday’s Forecast

## Slide 3

## Slide 4

## Observations

## Link to Satellite Loop

- _[http://adds.aviationweather.gov/satellite/displaySat.php?region=US&isingle=multiple&itype=](http://adds.aviationweather.gov/satellite/displaySat.php?region=US&isingle=multiple&itype=ir)__[ir](http://adds.aviationweather.gov/satellite/displaySat.php?region=US&isingle=multiple&itype=ir)_

## Slide 7

- _[http://radar.weather.gov/ridge/Conus/southplains_loop.](http://radar.weather.gov/ridge/Conus/southplains_loop.php)__[php](http://radar.weather.gov/ridge/Conus/southplains_loop.php)_

## Slide 9

## Slide 10

## Slide 11

## Slide 12

## Slide 13

## METARs 

**METARs**
- (9 am CDT)
**PNC**: **Ceiling:** at least 12,000 feet AGL
**Clouds:** sky clear below 12,000 feet AGL
**OKC**: **Ceiling:** 18000 feet AGL
**Clouds:** scattered clouds at 15000 feet AGLbroken clouds at 18000 feet AGLbroken clouds at 25000 feet AGL
**END**: **Ceiling:** at least 12,000 feet AGL
**Clouds:** sky clear below 12,000 feet AGL

## Slide 17

## Slide 18

## Slide 19

## Slide 20

## Slide 21

## Forecasts

## Slide 23

## Slide 24

## Slide 25

## Slide 26

## Slide 27

## Slide 28

## Slide 30

## Slide 31

- _[http://science.arm.gov/clasic/forecasts.](http://science.arm.gov/clasic/forecasts.php)__[php](http://science.arm.gov/clasic/forecasts.php)_

- _[http://www.nssl.noaa.gov/wrf/sdg/](http://www.nssl.noaa.gov/wrf/sdg/)_

## Extended Outlook

## Slide 35

## Slide 36

## Slide 37

## Slide 38
# Presentation: 488465

## Oxidation Resistant Ti-6Al-4V-SiC Composite Materials by Ion-Beam Processing

-   Demonstrated significant reduction in bacterial growth and 	colonization on treated medical device surfaces
**COMMERCIALIZATION**
- Foundations of the antimicrobial coating technology were developed under NIH and NSF grants and contracts.  Continued work with NIH includes development of silver-based antimicrobial coatings for additional medical device applications.
- Earlier, the NASA SBIR Phase I contract contributed to the establishment of Spire’s ion beam assisted deposition (IBAD) processing capabilities, upon which the antimicrobial coating technology is based
- Spire currently processes over ten thousand medical device components annually, resulting in several hundred thousand dollars in annual revenues
- Broad medical device applications, i.e. various catheters and other implantable medical devices, are being pursued with significant growth expected over the next few years
- Increase in employment of 4 people

***Spire Corporation***
***Bedford, MA***

**S****mall**
**B****usiness**
**I****nnovation **
**R****esearch**

**GOVERNMENT/SCIENCE APPLICATIONS**
-   Potential uses in limiting device-related infection 			for military applications/personnel
-   St. Jude Medical is currently using the Antimicrobial 			Coatings on prosthetic mechanical heart valve suture 		rings

- Lewis Research Center
- Technical Area - Materials
- 3-011

**Oxidation Resistant Ti-6Al-4V-SiC Composite Materials by Ion-Beam Processing**

***Antimicrobial IBAD silver coated***
*** ******medical device components***

**INNOVATION**

- 1987 Phase I, NAS3-25326, 6/98
- NASA Contact - James Smialek
- Company Contact - Ron Scharlack

- Developed silver-based antimicrobial coatings for reducing bacterial adhesion and proliferation on medical devices.

- 980578A
# Presentation: 935813

## University of Minnesota-Twin Cities MRSEC Timothy P. Lodge DMR-0212302 Double Delivery (IRG 1)

- Micelles are widely touted as possible storage and delivery vehicles for a range of insoluble, active molecules, such as pharmaceuticals, gene therapy agents, and pesticides. More recently it has been recognized that, if a micelle were constructed with a subdivided core, different molecules could be solubilized in the two (or more) core compartments. This would enable simultaneous delivery, in prescribed stoichiometric proportions, of two molecules that might be otherwise incompatible. April Rasdal, an undergraduate student, and Zhibo Li, a graduate student working jointly with Professors Tim Lodge and Marc Hillmyer, have just reported the first demonstration of the simultaneous uptake of two chomophores into separate micellar compartments. The micelles were prepared in water from "mikto-arm" EOF star terpolymers, where the three star arms were water-soluble poly(ethylene oxide) ("O"), hydrophobic poly(ethylethylene) ("E"), and lipo- and hydrophobic poly(perfluoropropylene oxide) ("F"). Pyrene was taken up exclusively in the hydrocarbon core compartments, whereas a fluorinated naphthalene derivative (NFH) was taken up preferentially in the fluorocarbon nanodomains (see Figure). [Lodge, T.P.; Rasdal, A.; Li, Z.; Hillmyer, M.A. Simultaneous, Segregated Storage of Two Agents in a Multicompartment Micelle. J. Am. Chem. Soc. 2005, 127, 17608.  Highlighted in Nature 2005, 438, 892]

**Figure**. Schematic illustration of selective storage of dye molecules in different micelle solutions. Pyrene is selectively taken up by EO micelles and NFH is selectively taken up by OF micelles. μ-EOF micelles can solubilize both dyes in a multicompartmented core.
# Presentation: 337652

## Accelerated Approvals in Oncology  A 10 - Year Experience

## Purpose

- Review past accelerated approvals
- Discuss current progress of associated phase 4 commitments
- Solicit input for improving the process

## Outline

- Oncology product AA from CDER and CBER
- Regulatory background
- Approvals based on controlled trials lacking a  concurrent comparator
- Approvals based on randomized studies
- Converted indications
- Issues for the committee

## Overview

- 19 NDAs or BLAs for new treatment indications (involving 16 drugs)
- Seven within l8 months of meeting invitation
- Subsequent full approval in 4
- Remaining 8 to be presented over next two days

## Regulatory Basis - Subpart H (21CFR 314)

- For serious or life-threatening diseases
- Where the drug appears to provide benefit over available therapy
- Approval based on a surrogate that is reasonably likely to predict clinical benefit

## 21CFR314 (continued)

- Subject to the requirement that the applicant verify and describe benefit
- Post-marketing studies would usually be underway
- The applicant shall carry out such studies with due diligence

## Endpoints in Oncology

- Survival and improvement in patient reported symptoms  considered clinical benefit
- Objective Response Rate and Time to Progression usually viewed as surrogates
-  RR representing benefit: relatively non-toxic products such as hormonal therapies or  some biologics

##  Approvals (no concurrent comparator)

## Approvals (no concurrent comparator)

## Approvals(no concurrent comparator)

## Approvals(randomized trials)

## Approvals(randomized trials)

## Endpoints Utilized

- No concurrent comparator : ORR
- Randomized setting : Cytologic response, number of polyps, ORR, TTP, DFS, LVEF ; CHF

## Uncertainty of Benefit to Ultimate Outcome

- Amifostine (Ethyol)
- Dexrazoxane (Zinecard)
- Anastrozole (Arimidex)
- Imatinib mesylate (Gleevec)
-  first-line CML

##  Timing of Confirmatory Trials  Converted Indications

## Sponsor Presentations

##  Protocol Issues

- Has accrual been satisfactory ?
- If not, what strategies can  address this ?
- Have changing circumstances impeded the conduct of a planned trial ?
- If so, what alternative designs should be contemplated ?