# Presentation: 112471

## CTSA and PBRNs

- Can this relationship be saved?

## What is new here?

** ****NIH initiative to strengthen the discipline of clinical and translational research**
** ****Share data and experiences across a national partnership **
** ****Increase local control, institutional flexibility**
** ****Support protocol handling, regulatory knowledge and subject recruitment for investigators**
** ****Support clinical and translational investigators**

**What is new here?**

## Expanded research activity

## What is translational research?

**What is translational research?**
-  Relevance to human or population health
-  Involves collaborations across disciplines or areas of expertise

## Why is this so key to AMCs?

- Big money
- Will lose GCRC unless successful
- Will lose K30, related programs unless successful
- Creates a two-class system of haves, have nots
- Bragging rights
- But truly, AMCs see this as the future

## Slide 6

## Key points to understanding CTSA

- Infrastructure
- NIH funds substantially supplemented by institutional commitment
- Community, pediatrics are keys to full funding
- Replaces, restructures GCRC
- Encompasses K30 educational curriculum
- Inclusion of T32 (predoctoral) and K12 program (mentored career training)

## Basic Sciences

- External
- partners

- Clinical
- enterprise

- Clinician
- scientists

- CTSA

- Research
- Administration

## Required Elements

- Education and career development
- Research support/research ethic
- Informatics
- Translational technologies
- Biostatistics and study design
- Patient and clinician interaction resources (old GCRC)
- Evaluation
- Community engagement
- Pediatrics

## Slide 10

## The OCTRI Partners

**Community resources**

**OHSU/VA Hospitals and Clinics**

**Kaiser Permanente**
**Center for Health Research**

**OHSU **
**All schools**
**Emphasis on pediatrics**
**and community**

## Oregon Clinical and Translational Research Institute 

**Oregon Clinical and Translational Research Institute**

## OCTRI Specific Aims

- Develop a cadre of highly trained interdisciplinary researchers through a strong educational curriculum
- Directly support research and investigators
- Create and streamline a "Research Commons"
- 	- Coordinated, effective research support system
- 	- Make research infrastructure more accessible to 	researchers through a single "Front Door”
- Catalyze research by creating an academic home for clinical and translational research

## Special Emphases

- Collaborations and resources specifically targeted toward increasing pediatric clinical/translational research
**Community Research/TRIPP**
- 	Coordination of several important community based research resources (ORPRN, one developing safety net PBRN, two dental PBRNs)

## OCTRI Award

-   5 year grant; $55M total costs
-  *Key to PBRN:  Full award level only possible with inclusion  of strong community engagement, pediatrics *
_**Institutional support**_
-   Space, educational support (mentor FTE), flexible
-   funding, core expertise, faculty FTE

## Slide 16

## I. Develop a cadre of investigators through a strong educational curriculum

- _PBRN offers to CTSA_
- PBRN leaders can teach and mentor
- Provide resource to highlight T2 research to trainees
- Provide a reliable source of community trainees
- Can advance qualitative research and CBPR by increasing knowledge

- _CTSA offers to PBRN_
- Train clinician members, staff
- Student grants for research thru T32
- Mentored clinical research training awards (K12) for faculty
- Interact with young researchers developing projects, careers

## 2.  Directly support research and investigators

- _PBRN offers  to CTSA_
- Identify and support development of new collaborations
- Infrastructure support
- Source for dissemination and implementation research

- _CTSA offers to PBRN_
- Increased awareness, prominence
- Instigate new collaborations
- CTSA provides seed money to develop collaborations, pilot and feasibility data
- Infrastructure support

## 3.  Streamline, coordinate research support system, make more accessible

- _PBRN offers to CTSA_
- Provide core resource, populations
- Engage the community – perhaps key to PBRN involvement

- _CTSA offers to PBRN_
- Access to integrated, supported core resources
- 	- Biostatistics, informatics, study design, core labs, GCRC, integrated IRBs, DSMBs
- Create advocates, partners for community research outside PBRN

## 4. Enhance the academic environment for clinical/translational research

- _PBRN offers to CTSA_
- Can advance methods research in PBRNs
- Engage the practice community and larger community
- Focus for CBPR

- _CTSA offers to PBRN_
- Enhance research through involving senior researchers (OCTRI Academy)
- Seminar series, visiting professorships
- Create regional partnerships
- Special opportunities thru NIH

## How to position your PBRN for CTSA?

- Be successful, compete for grants
- Be collaborative
- Participate in developing the community section
- Help write the community section
- Tell your story well
- Be able to describe your PBRN in detail, population, research, successes
- Understand what CTSA is and is not
- Manage expectations

## So what can you do?

*Educate* your CTSA leaders about the importance of T2 and T3 translation
- Provide examples of successful dissemination, implementation, diffusion research
*Understand* the CTSA is not necessarily a source of support for the PBRN
- Negotiate to include institutional support for the PBRN as institutional commitment

## So what can you do?  

*Be patient* - this is a huge, complex endeavor
- Implementing services, building infrastructure takes a long time
*Advocate, *have your voice heard over the din
- The PBRN will make the CTSA application better in every way
*Be persistent!*