# Presentation: 347311

## AVT Phase II Use Case Model

- Bob Schwanke
- Version of 2008-Dec-11

## How to read this document

- A ***Use Case*** is a category of behavior
- Use Cases are organized as a hierarchy, partially ordered by
- Includes
- Includes, optionally [“is extended by” in UML]
- Has special case [“has subclass” in UML]
- Use Case hierarchy has a single root
- The “includes” list only *suggests* an ordering, but does not *specify* the order or the number of repetitions
- A composite use case usually has 3-9 children
- A ***Scenario*** is an example of a Use Case
- Specifies a sequencing of parts of the use case
***{ ***braces ***} ***contain implementation priorities
- {1} will certainly be built for SIIM ’09, to support the first user study
- {2} will probably be built for SIIM ’09, to support additional user studies specified in this model
- {later} will probably *not* be built for SIIM ’09
- Also note Vocabulary and Terms to Avoid

## Vocabulary

***Scan***: one logical image, whether 2D, 3D, or 4D; includes PET-CT fused data scan.
***Scan-series***: a temporal sequence of 2 or more scans of the same subject
*A scan-series is a constructed object that associates two or more scans of the same subject in a temporal sequence. Scan-series are used for AVT studies that investigate change in tumors from one scan to the next, such as “coffee break” and “before and after treatment”.*
***Landmark***: a naturally-occurring anatomical feature used for systematic, uniform orientation and measurement.
***Fiducial***: an artificial mark, such as a tattoo, placed in or on a subject to facilitate systematic, uniform orientation and measurement.
***Nodule***: lesion, tumor, lump, etc.
- See also _[Terms to Avoid](slide4.xml)_
*Note: this terminology is temporary, pending reconciliation with the RadLex team.*

## Terms to Avoid

*The following terms are ambiguous and should be avoided.*
***Image***: always modify it, e.g. *DICOM Image* or *logical image *or* image processing*, or use *scan*.
***Study***: always modify it, e.g. *DICOM Study*, *AVT Study, *or* reader study*.
***Series***: always modify it, e.g. *DICOM Series* or *scan-series*.

## AVT context

- Interfaces:
**DICOM Database**
- Exchange DICOM objects with other DICOM databases (which are (a) local or (b) caGRID DICOM Data Services) {1}
**AIM Database**
- Exchange AIM objects with other AIM databases (which are (a) local or (b) caGRID AIM Data Services). (Data model will be an extension of the AIM object model.) {1}
**AVT Study Database**
- Exchange AVT study data with other study databases, (a) directly, and (b) eventually using a suitable caGRID Data Service. {later}
**Manual annotation** interface {1}
**Algorithm execution interface**
- Batch execution of algorithm on many images {2}
**Measurement Variability Analysis Interface **{1}
**Installation and configuration** interface {1}
**Development and customization interface **{1}
**Data management** interface
- Collect and organize images, annotations, and study data {1}

## AVT {1}

- Includes
- install AVT {1}
- design _[AVT study](slide7.xml)__ _{1}
- (optionally) _[install image processing algorithm](slide37.xml)__ _{2}
- (optionally) _[customize annotation tool](slide39.xml)__ _{2}
- (optionally) _[customize measurement variability tool](slide40.xml)_{2}
- (optionally) exchange data with other sites {1}
- _[conduct AVT study](slide41.xml)__ _{1}
- Context: _[AVT context](slide5.xml)_

## AVT study (data type) {1}

- Includes
- Relationship to nominal ground truth: [ **unknown** | **known **{1} | **calculating**]
- General Goal: [ **exploration **{1} | **validation **{1} | **algorithm improvement**]
- _[annotation task ](slide8.xml)__to be analyzed _{1}
- Source of scan data {1}
- _[independent variables](slide23.xml)__ _{1}
- _[comparisons](slide26.xml)__ _{1}
- _[statistical methods](slide29.xml)__ _{1}
- _[study representation](slide31.xml)__ _{1}
- Has special case
- _[Example AVT Studies](slide32.xml)__ _{1}
- Part of AVT  conduct AVT study  algorithmically annotate scans

## annotation task {1}

- “Annotation” includes both attaching graphics (markup) to images and attaching structured data (annotations) to scans and scan-series.
- Most annotation tasks could be carried out manually, semi-automatically, or automatically. Except where indicated, the model describes all three possibilities with the same use-cases.
- Includes, optionally
- (manually) read annotation instructions {2}
- _[scan annotation task](slide9.xml)__ _{1}
- _[scan-series annotation task](slide16.xml)__ _{later}
- evaluate task output: confidence, accuracy {2}
- add _[audit trail information](slide21.xml)__ _{2}
- add _[pedigree information](slide22.xml)__ _{2?}
- Part of _[AVT](slide6.xml)__ _ _[AVT study](slide7.xml)_
- Part of _[AVT](slide6.xml)__ _ conduct AVT study  _[algorithmically annotate scans](slide44.xml)_

## scan annotation task {1}

- Includes, optionally,
- _[locate task-object](slide10.xml)_ {2?}
- measure diameter(s): RECIST {1} , WHO {2?}, Wolfe
- _[segment task-object](slide12.xml)_ {1}
- _[describe task-object](slide13.xml)_ {2?}
- create atlas of scan {later}
- rate scan quality {later}
- has special case
- _[annotate scout scan](slide14.xml)_ {later}
- _[annotate tumor](slide15.xml)_ {1}
- Part of _[AVT](slide6.xml)_  AVT study  _[annotation task](slide8.xml)_

## locate task-object {2?}

*Includes locating one or more of the following *
- Seed point
- Maximal slice
- Center of mass
- Landmark point
- Region of interest (ROI) surrounding task object
- Part of _[AVT](slide6.xml)__ _ AVT study  annotation task  _[scan annotation task](slide9.xml)_
- Note: finding an ROI and then segmenting the object in it can also be called unsupervised segmentation

## task object {1} 

- Has special case
- Nodule {1}
- Lymph node {later}
- Organ {later}
- Landmark {later}
- Some of these task object types are not relevant for certain tasks.
- Includes (attributes)
- ???
- Part of _[AVT](slide6.xml)__ _ AVT study  annotation task  scan annotation task  locate task object segment task object _[describe task object](slide13.xml)_
- Part of _[AVT](slide6.xml)__ _ AVT study  annotation task  scan-series annotation task  _[track task-object across scan-series](slide19.xml)_

## segment task object {1}

- Includes, optionally
- mark a seed point contained within the task object {1}
- mark a “stroke” contained within the task object
- mark an ROI containing the task-object {later}
- algorithmically estimate boundary {1}
- interactively delineate or improve boundaries of entity {1}
- algorithmically calculate diameter(s), area(s) and/or volume {1}
- Has special case
- 2D segmentation {later}
- 21⁄2D segmentation {2?}
- 3D segmentation {1?}
- Done semi-automatically, with nudging to improve on algorithmic estimate
- create 3D model out of tumor boundary on each slice or three orthogonal slices automatic or interactive (nudging)
- Region growing, watershed methods, level sets, etc.
- Part of _[AVT](slide6.xml)_  AVT study  annotation task  scan annotation task  _[annotate tumor](slide15.xml)_

## describe task object {2?}

- Includes, optionally
- Classify
- Characterize
- Density
- Margin distinctness
- Shape regularity
- etc.
- Actionability
- Attach clinical information to task object
- biopsy info
- outcome
- etc.
- Part of _[AVT](slide6.xml)_  AVT study  annotation task  _[scan annotation task](slide9.xml)_
- RECIST demo of this capability could perhaps be ready for SIIM 09

## annotate scout scan (localizer) {later}

*Purpose: define range and orientation of a diagnostic scan*
- Includes
-  (optional) select best slices
- Attach landmark points to landmarks [according to instructions]
- Special case of _[AVT](slide6.xml)__ _ AVT study  annotation task  _[scan annotation task](slide9.xml)_

## annotate tumor {1}

- Includes, optionally
- find tumor (identification, seed point?) {later?}
- find center of mass of tumor (algorithmic only) {later?}
- find maximal slice (axial slice in which tumor has maximum extension) {later?}
- find most aggressive part {later}
- measure longest diameter within slice (RECIST) {1}
- measure longest orthogonal diameters (2D for WHO {2?}, 3D for Wolfe Criteria {later} )
- imprecise localization (e.g. ellipse, ROI) {later}
- _[segment task object](slide12.xml)_ {1}
- _[Describe task object ](slide13.xml)_(tumor) {later?}
- e.g. density, margin distinctness, attach biopsy information to tumor *(biopsy info may have been collected separately under curation)*
*Note: annotation methods are different depending on the type of tumor, the organ where it is located, and its size, among other things.*
- Special case of _[AVT](slide6.xml)_  AVT study  annotation task  _[scan annotation task](slide9.xml)_

## scan-series annotation task {later}

- Includes, optionally
- _[register scan-series](slide17.xml)_
- _[track ](slide19.xml)__[task-object](slide19.xml)__[ across scan-series](slide19.xml)_
- Measure change in *task-object*
- classify change
- characterize change
- attach additional treatment history (e.g. radiation therapy)
- Has scenario
- _[Oncocare](slide20.xml)__[ registration scenario](slide20.xml)_
- Part of _[AVT](slide6.xml)_  AVT study  _[annotation task](slide8.xml)_

## register scan-series {later} 

- Includes, optionally
- Select ROI to register
- Use _[registration algorithms](slide18.xml)__ to estimate registration_
- Manually adjust registration
- 4D registration to account for tumor movement while breathing
- measure quality of registration (e.g. normalized mutual information)
- visualize quality of registration (e.g. subtraction image)
- Has special case
- Register images of same type (e.g. helical CT)
- Register images of different types (e.g. PET/CT, MR/CT, Helical/Cone CT)
- Part of _[AVT](slide6.xml)__ _ AVT study  annotation task  _[scan-series annotation task](slide16.xml)_

## registration algorithms {later}

- These are automatic registration methods, which the reader may invoke, but which may cause bias if used to speed up defining registration nominal ground truth.
- Includes, optionally
- Rigid registration
- Affine registration
- Deformable registration
- Part of _[AVT](slide6.xml)__ _ AVT study  annotation task  scan-series annotation task  _[register scan-series](slide17.xml)_

## track task-object across scan-series {later}

*Linking objects (e.g. tumors) in two or more scans to indicate that they are believed to be the same object, or one birthed from the other, etc.*
- Includes, optionally
- Linking objects by seed points
- Linking objects by centers of mass
- Linking objects by contours
- Linking objects by maximal slices
- Tracking 3D object in 4D scan
- Part of _[AVT](slide6.xml)__ _ AVT study  annotation task  _[scan-series annotation task](slide16.xml)_
*RECIST Adjudicator could illustrate this use-case{2?}*

## OncoCare registration scenario {later}

- With two scans,
- Perform rigid registration of whole scans
- Select small ROI around tumor in one scan
- Calculate deformation field to other scan
- Map center of mass of tumor from first to second scan
- Example of _[AVT](slide6.xml)__ _ AVT study  annotation task  _[scan-series annotation task](slide16.xml)_
- Can be semi-automatic (for manual annotation) or automatic (for auto-annotate), depending on whether ROI can be found automatically.

## audit trail information {2} 

*The term pedigree, as it appears in the Gap Analysis Document, combines two concepts: audit trail information and expert commentary, the latter explaining why an annotation is what it is. In this model, we use “pedigree” to refer only to expert commentary. AVT will take care of recording audit trail information automatically, so it is not explicitly listed as a part of any particular use case. *
- audit trail information includes, optionally
- start/source data
- changes/measurements made
- tools used, with versions
- user
- date/time of annotation
- Part of _[AVT](slide6.xml)__ _ AVT study  _[annotation task](slide8.xml)_
*Audit trail information might be attached to almost any annotation.*

## pedigree information {2?}

- includes, optionally
- methods used to establish nominal ground truth
- subjective uncertainty of observations
- Part of _[AVT](slide6.xml)__ _ AVT study  _[annotation task](slide8.xml)__ _
- Part of _[AVT](slide6.xml)__ _ conduct AVT study  _[curate collection](slide42.xml)_
*The term pedigree in the Gap Analysis document combines two concepts: audit trail information and expert commentary, the latter explaining why an annotation is what it is. In this model, we use “pedigree” to refer only to expert commentary. *
*Pedigree might be attached to almost any annotation. Need better word.*

## independent variables {1}

- Scanner variables
- _[Modality](slide24.xml)_
- Hardware type (field strength, detector number, etc.)
- Slice thickness, spacing, exposure
- Subject variables (Age, Sex; phantom; species; vitality; country of scan; _[organ scanned](slide24.xml)__; time between scans in scan-series)_
- Disease variables (e.g. Referral criteria; outcomes)
- Reader variables (incl. inter-reader variation)
- Algorithm variables
- _[repetition method](slide25.xml)__ (incl. intra-reader variation)_
- Part of _[AVT](slide6.xml)__ _ _[AVT study](slide7.xml)_

## scan (data type) {1}

- Has special case
- Modality-type scan, e.g.
- CT scan
- MR scan
- PET scan
- PET-CT (fused data) scan
- Nuclear scan
- Ultrasound (3D, 4D) scan
- Xray (e.g. mammogram)
- Etc. ?
- Organ-type scan, e.g.
- Liver scan
- Lung scan
- Brain scan
- Breast scan
- Etc.

- Subject-type scan, e.g.
- Patient scan
- Healthy subject scan
- Animal scan
- Phantom scan
- Post-mortem scan?
- Derived scan, e.g.
- Translated/rotated scan
- Injected-noise scan
- Simulated scan
- (derived from statistical characteristics of real scans? derived from examples?)
- Manipulated scan
- Includes hybrids, such as simulated tumors added to images of healthy patients.
- Part of _[AVT](slide6.xml)__ _ AVT study  _[independent variables](slide23.xml)__ _
- Part of _[AVT](slide6.xml)__ _ conduct AVT study  _[curate collection](slide42.xml)_

***Scan***: one logical image, whether 2D, 3D, or 4D.
- The special cases below are only intended to note some of the DICOM attributes that are relevant to AVT scans.
- Each special case requires certain parametric differences in how annotation tasks are performed.

## repetition method {1}

- Has special case
- Rescan before disease progresses (e.g. minutes, days)
- Re-reading same image after “forgetting”
- Reading derived images
- Part of _[AVT](slide6.xml)__ _ AVT study  _[independent variables](slide23.xml)_

## comparisons {1}

- Includes
- attributes to compare
- data organization for inputs and outputs of comparisons
- Includes, optionally
- comparisons to nominal ground truth annotations {1}
- _[diameter comparisons ](slide27.xml)_{1}
- _[volume comparisons](slide28.xml)_ {1}
- registration comparisons {later}
- alignment comparisons {later}
- description comparisons {later}
- More, TBD
- Part of _[AVT](slide6.xml)_  _[AVT study](slide7.xml)_
- Part of _[AVT](slide6.xml)_  conduct AVT study  _[compare annotations](slide45.xml)_
- ? Reqt: Job batching

## diameter comparisons {1}

- Includes, optionally
- RECIST difference (1D) {1}
- WHO difference (2D) {2?}
- Wolfe difference (3D) {later}
- normalized RECIST difference {1}
- normalized WHO difference {2?}
- Normalized Wolfe difference {later}
- Part of _[AVT](slide6.xml)__ _ AVT study  _[comparisons](slide26.xml)_
- Part of _[AVT](slide6.xml)__ _ conduct AVT study  compare annotations  _[comparisons](slide26.xml)_

## volume comparisons {1}

- Includes, optionally
- volume difference {1}
- abs. of volume difference {1}
- normalized volume difference {1}
- abs. of normalized volume difference {1}
- volume overlap ratio {later}
- over-segmented ratio {later}  (what is this???)
- under-segmentation ratio {later}
- surface distance (RMS, 75th percentile, maximum) {later}
- smoothness difference {later}
- shape difference {later}
- connectedness difference {later}
- Part of _[AVT](slide6.xml)__ _ AVT study  _[comparisons](slide26.xml)_
- Part of _[AVT](slide6.xml)__ _ conduct AVT study  compare annotations  _[comparisons](slide26.xml)_

## statistical methods {1}

- Includes, optionally
- mean {1}
- Bias {1}
- SD (Standard Deviation) {1}
- CV (Coefficient of Variation) {later}
- linear regression {later}
- correlation {later}
- Kruskal-Wallis analysis
- multiple comparison {later}
- Wilcoxon signed rank test {later}
- sensitivity, specificity {later}
- PPV (positive predictive value), NPV (negative predictive value {later}

- STAPLE (boundary or classification agreement metric, pixel by pixel???) {later}
- ROC (Receiver Operating Characteristic) curve (efficiency of classification) {later}
- FROC(efficiency for detecting targets) {later}
- Bland-Altmann charts {1}
- Box-and-Whisker charts {1}
- ANOVA methods {1}
- _[outlier criteria](slide30.xml)_ {1}
- More, TBD
- Part of _[AVT](slide6.xml)_  _[AVT study](slide7.xml)_
- Part of _[AVT](slide6.xml)_  conduct AVT study  _[analyze annotation variability](slide46.xml)_

## outlier criteria {1}

- Includes, optionally
- Outlying data points {1}
- Scaling by interquartile range (IQR) {1}
- Scaling by standard deviations (SD) {1}
- Cutoffs (e.g. 25th percentile, ±2 SD) {1}
- Outlying sub-distributions (means and SDs) {2}
- Scaling by SD of means {2}
- Scaling w.r.t. Levene test? {later?}
- Scaling w.r.t. Bartlett test? {later?}
- Scaling w.r.t. ANOVA test? {2?}
- Scaling w.r.t. Kruskal-Wallis test? {later?}
- Part of _[AVT](slide6.xml)_  _[AVT study](slide7.xml)_  _[statistical methods](slide29.xml)_
*A sub-distribution is a distribution of values of a dependent variable drawn from a subset of the data, (or, equivalently, a sub-group of the cases), typically selected by a query that restricts the ranges of the independent variables, e.g. “just the women over age 65”. If a sub-distribution has significantly different aggregate statistics from the remainder of the collection, it may indicate a source of variation.*

## study representation {1}

*These are AVT-specific details*
- Includes
- Annotation labeling plan {1}
- Need labels on annotations indicating their roles in the study, so that AVT can find and process them.
- Measurement and statistics representation (“data cube” schema) {1}
- Specifies how the independent and dependent variables, comparisons, and statistical calculations are organized.
- Data views (e.g. image views, table views, chart views) {1}
- How the data appears in the user interface of AVT’s MVT.
- Part of _[AVT](slide6.xml)_  _[AVT study](slide7.xml)_

## example AVT studies {1}

- Has special case
- RIDER Lung Nodules Study(?){?}
- _[CDRH Phantom Tumor Reader Study](slide34.xml)_{1?}
- _[RadPharm](slide33.xml)__[ Study](slide33.xml)_{2?}
- _[AVW Platform Liver Tumor Study](slide35.xml)_{?}
- U. Maryland Injected Noise Study{?}
- More, TBD
- Template for Example AVT Study
- Is special case of _[AVT](slide6.xml)_  _[AVT study](slide7.xml)_

## RadPharm Study {2?} (draft)

**Context**: measuring tumor change in drug clinical trials
**Relationship to nominal ground truth**: calculate, then known
**Goal**: validate a tumor segmentation algorithm
**Annotation task**: _[annotate tumor](slide15.xml)_, esp.
- measure diameters: RECIST, WHO
- _[segment tumor](slide12.xml)_, esp.
- 3D segmentation, volume
**Source of scan data**
- MICCAI Data?
- FDA Phantom Tumor Data?
- _[Independent variables:](slide23.xml)_
- Scanner variables: TBD
- Subject variables: TBD
- Disease variables: TBD
- Reader variables
- N human readers
- nominal ground truth Annotations performed in AVT
- Inter-reader variation
- Algorithm variables
- Semi-automatic segmentation performed off-line and transcoded from DICOM SR to AIM
- _[repetition method](slide25.xml)_: intra-reader variation, more TBD
- Fallback plan: If semi-automatic algorithm not available in time, just study inter-reader variability

- _[Comparisons](slide26.xml)_**, **esp**.**
- comparisons to nominal ground truth annotations
- _[volume comparisons](slide28.xml)_, esp.
- volume difference
- abs. of volume difference
- normalized volume difference
- abs. of normalized volume difference
- Not interested in volume overlap measurements
- _[diameter comparisons ](slide27.xml)_, esp
- RECIST difference (1D)
- normalized RECIST difference
- _[Statistical methods](slide29.xml)_, esp.
- Mean
- bias
- SD (Standard Deviation)
- Bland-Altmann Plot
- ANOVA methods
- _[study representation](slide31.xml)_: TBD
- Special case of _[AVT ](slide6.xml)_ AVT study  _[example AVT studies](slide32.xml)_

## CDRH Phantom Tumor Reader Study {1?} (very early draft)

**Context**: analyzing sources of variation in tumor imaging
**nominal ground truth**: known
**General Goal**: **exploration** of reader variation
**annotation task**: annotate tumor, esp.
- manual RECIST and WHO annotations
- semi-automatic volume segmentation
**Source of scan data**: FDA Phantom Thorax nodule data
- _[independent variables](slide23.xml)_
- CT Acquisition parameters: Exposure, Pitch, Collimation, Slice Thickness, Reconstruction Kernel
- Scanner variables: CT: Exposure, Pitch, Collimation, Slice Thickness, Reconstruction Kernel
- Subject variables: Phantom; thorax
- Disease variables: (Nodule characteristics: Attached, unattached, spherical, elliptical, lobulated, spiculated, random)
- Reader variables: Human
- Using AVT annotation tool
- Inter-reader variation
- Etc, TBD
- Algorithm variables: TBD
- _[repetition method](slide25.xml)_: repositioning, intra-reader variation

- _[Comparisons](slide26.xml)_
- comparisons to nominal ground truth annotations
- RECIST and WHO diameters and volume known by construction of phantom.
- _[diameter comparisons ](slide27.xml)_, esp. RECIST, WHO
- _[volume comparisons](slide28.xml)_, esp.
- Tumor 3D segmentation and its volume
- Interested in volume overlap measurements?
- How do(es) algorithm(s) compare to human readers?
- _[statistical methods](slide29.xml)_
- Bias
- Mean error
- variance
- Prioritize outliers by measuring in multiples of Standard Deviation or Inter-quartile range
- Box-and-whiskers plots
- Bland-Altmann Plot?
- See Chenyang’s team’s papers?
- _[study representation](slide31.xml)_: TBD
- Special case of _[AVT ](slide6.xml)_ AVT study  _[example AVT studies](slide32.xml)_

## AVW Platform Liver Tumor Study

- TBD

- Special case of AVT  AVT study  example AVT studies

## Template for Example AVT Study

**Context:**
**nominal ground truth**: [ unknown | known | calculating]
**General Goal:** **[ exploration | validation | algorithm improvement]**
- _[annotation task](slide8.xml)__[ ](slide8.xml)__to be analyzed_
- _[scan annotation task](slide9.xml)_
- _[scan-series annotation task](slide16.xml)_
**Source of scan data**
- _[independent variables](slide23.xml)_
- Scanner variables
- Subject variables (Age, Sex; phantom; species; vitality; country of scan; _[organ scanned](slide24.xml)__)_
- Disease variables (e.g. Referral criteria; outcomes)
- Reader variables, incl. inter-reader variation
- Algorithm variables
- _[repetition method](slide25.xml)__: [Repositioning | Re-reading | derived images], incl. intra-reader variation_
- _[Comparisons](slide26.xml)_
- attributes to compare
- comparisons to nominal ground truth annotations
- _[volume comparisons](slide28.xml)_
- _[diameter comparisons ](slide27.xml)_
- registration comparisons
- alignment comparisons
- description comparisons

- _[statistical methods](slide29.xml)_
- Mean
- bias
- SD (Standard Deviation)
- CV (Coefficient of Variation)
- linear regression
- correlation
- Kruskal-Wallis analysis
- multiple comparison
- Wilcoxon signed rank test
- sensitivity, specificity
- PPV (positive predictive value), NPV (negative predictive value
- STAPLE (boundary or classification agreement metric, pixel by pixel???)
- ROC (Receiver Operating Characteristic) curve (efficiency of classification)
- FROC(efficiency for detecting targets)
- Bland-Altmann charts
- Box-and-Whisker charts
- ANOVA methods
- _[outlier criteria](slide30.xml)_
- _[study representation](slide31.xml)_: TBD
- Special case of _[AVT ](slide6.xml)_ AVT study  example AVT studies
*Copy and modify this template to describe your study. Follow links for relevant parts of business use-case model.*

## install image processing algorithm {2}

- Includes, optionally
- _[install c++ image processing algorithm](slide38.xml)__ in a scene graph library_
- Install algorithm written in another programming language in a scene graph library
- Configure AVT to load custom scene graph library
- Configure a scene graph pipeline to implement a (new) image processing algorithm
- Part of _[AVT](slide6.xml)_

## install C++ image processing algorithm {2}

- Includes
- Embed image processing algorithm in a subclass of a suitable XIP scene graph component class
- Compile and link scene graph component into a binary library (e.g. a DLL in Windows)
- Part of _[AVT](slide6.xml)__ _ _[install image processing algorithm](slide37.xml)_
*AVT provides an example to copy and modify.*

## customize annotation tool {2}

*Tailor the annotation tool to fit the intended AVT study, thereby eliminating extraneous variability caused by using a too-general tool.*
- Includes, optionally
- develop IA user interface components to fit AVT study
- develop IA scene graph to fit AVT study
- Part of _[AVT](slide6.xml)_

## customize measurement variability tool {2}

*Customize MVT to support the particular kinds of calculation and exploration needed for the intended statistical scan. For data exploration, typically means adding new modules to the growing bag of tricks, and perhaps configuring the menus to conveniently access frequently-used ones. For the actual validation, may involve writing new components that pull together chosen analysis methods to present the results.*
- Includes, optionally
- Develop R package to fit MVT/R interface
- Load R package into MVT
- Configure MVT menus
- Configure MVT tabcards or write new ones
- Configure MVT report generators or write new ones
- Configure MVT table views or write new ones
- Configure MVT image views or write new ones
- Configure MVT image scene graph
- Part of _[AVT](slide6.xml)_
- AVT supplies an example to copy and modify

## conduct AVT study {1} 

- Includes, optionally
- _[curate collection](slide42.xml)__ _{1}
- manually do _[annotation task](slide8.xml)__ specified in AVT study _{1}
- _[algorithmically annotate scans](slide44.xml)__ _{2}
- _[compare annotations](slide45.xml)__ _{1}
- _[analyze annotation variability](slide46.xml)__ _{1}
- Part of _[AVT](slide6.xml)_

## curate collection {1} 

- Includes
- Define criteria for collecting _[scans](slide24.xml)__, _{1} e.g.
- Age, Sex, Referral criteria, Hardware type (field strength, detector number, etc.)
- Slice thickness, exposure
- Country of scan, scan _[subject type](slide24.xml)_
- Define criteria and instructions for annotating scans {1}
- Need automated query support for selecting based on these criteria
- Add scans to collection {1}
- (optional) create scan-series and add to collection {later}
- add vetted patient demographics (maybe from DICOM header) {1}
- add vetted clinical data (such as outcomes) {1}
- _[add pedigree information](slide22.xml)__ to whole collection _{2}
- _[certify nominal ground truth](slide43.xml)__ _{1}
- Part of _[AVT](slide6.xml)__ _ _[conduct AVT study](slide41.xml)_

## certify nominal ground truth {1}

*nominal ground truth is established on scans and scan-series, typically by statistically analyzing multiple attempts to estimate that annotation, manually and/or automatically, and recording the estimate as a new annotation on the relevant case. *
*nominal ground truth can also be associated with histology, diagnoses, pathology, and follow-up*
- includes, optionally
- Add an annotation to an annotation indicating that it is the most recent best estimate of the nominal ground truth for that annotation type, for the object being annotated.
- Add a pedigree note to a collection indicating that a certain tag on annotations in that collection marks it as ***nominal ground truth*** for a specified purpose. The note also documents how the nominal ground truth was determined.
- Part of _[AVT](slide6.xml)__  _ conduct AVT study  _[curate collection](slide42.xml)_
- Need version tracking information to handle cases where nominal ground truth evolves.

## algorithmically annotate scans {2}

- Includes
- Specify algorithms to run to perform _[annotation task](slide8.xml)__ specified in AVT study _{2}
- configure labeling scheme for generated annotations, so they can be found later for analysis {2}
- Specify sampling scheme for choosing which scans in collection will be annotated {later}
- Sampling from space of  <scans x algorithms x parameters>
- Execute specified algorithm on chosen scans {2}
- Review results of algorithm execution (did it do what I meant?){2}
- Part of _[AVT](slide6.xml)__ _ _[conduct AVT study](slide41.xml)_

## compare annotations {1}

- Includes
- Execute comparisons specified in AVT study
- Review comparisons (did it do what I meant?)
- Part of _[AVT](slide6.xml)__ _ _[conduct AVT study](slide41.xml)_

## analyze annotation variability {1}

- Includes
- Calculate statistics specified in AVT study {1}
- _[review statistics results](slide47.xml)__ _{1}
- Generate variability reports specified in study representation of AVT study {1}
- E.g. statistics reports with some typical images
- Part of _[AVT](slide6.xml)__ _ _[conduct AVT study](slide41.xml)_

## review statistics results {1}

*Review data, interactively, as specified in study representation of AVT study.*
- Includes, optionally
- Prioritized lists of outliers {1}
- Prioritized lists of outlying sub-distributions {2}
- Graphs {1}
- Tables {1}
- Drill-down to details of outliers
- view scans {1}
- sub-distributions {2}
- More, TBD
- Part of _[AVT](slide6.xml)__ _ _[conduct AVT study](slide41.xml)_ 		 _[analyze annotation variability](slide46.xml)_

## Backup slides

- No! Don’t Back Up!

## Concepts not yet covered adequately in model

- From UCLA team
- Algorithms involving functional measures (Dynamic Contrast Enhanced MRI, for example)
- Other Oncology examples (talk about later)
- Morphological change
*Suggestions solicited for how to incorporate these in model.*