# Presentation: 077681

## Characteristics of AEGLs

**DISABLING**

**DISCOMFORT**

**HAZARD ASSESSMENT**

**Effects**

**Threshold Levels**

-  Increasing likelihood of death

- Impairment of ability to escape
- Increasing severity of irreversible or other serious long-lasting effects

- Increase in notable discomfort
- Increasing severity of reversible effects (with or without signs/symptoms)

- Increasing complaints of objectionable odor, taste, sensory irritation or other mild, non-sensory or asymptomatic effects

## Example 1:  AEGL Values for Carbon Monoxide (ppm) 

|  | 10 min | 30 min | 1 hour | 4 hours | 8 hours |
| --- | --- | --- | --- | --- | --- |
| AEGL-1 | NR | NR | NR | NR | NR |
| AEGL-2 | 420 | 150 | 83 | 33 | 27 |
| AEGL-3 | 1700 | 600 | 330 | 150 | 130 |

## Example 2: AEGL Values for Hydrogen Sulfide (ppm) 

|  | 10 min | 30 min | 1 hour | 4 hours  | 8 hours |
| --- | --- | --- | --- | --- | --- |
| AEGL-1 | 0.75 | 0.60 | 0.51 | 0.36 | 0.33 |
| AEGL-2 | 41 | 32 | 27 | 20 | 17 |
| AEGL-3 | 76 | 59 | 50 | 37 | 31 |
| Level of Odor Awareness = 0.01 ppm |  |  |  |  |  |

## AEGL “Vulnerable”/ “Safe” Zones

- Discomfort
- (AEGL-1)

- Disability
- (AEGL-2)

- Death
- (AEGL-3)

- Release Site

- DETECTABILITY

## Effect of AEGL Value on Vulnerable Zone:  Example

**Case 1**: Compound X AEGL 2 = 0.001 mg/m3/60 min/ 3.4 mph wind speed, rural terrain, F atmospheric stability, 100 lb release (10 lbs/min)
- Vulnerable Zone = 9.0 miles
**Case 1**: Compound X AEGL 2 = 0.01 mg/m3/60 min/3.4 mph wind speed, rural terrain, F atmospheric stability, 100 lb release (10 lbs/min)
- Vulnerable Zone = 1.3 miles

## Slide 6

## Organization Lists Used for the Selection of

- ( ) Priority Chemicals
- 	ATSDR	Agency for Toxic Substances and Disease Registry (36)
- 		A = ATSDR "Top 20" Toxicology Profile Chemicals (6)
- 		B = Medical Management Guide Chemical (7)
- 		C = Chemicals with an ATSDR Toxicology Profile (33)
- 	DOD	Department of Defense (18)
- 		A = Chemical Weapons Convention Schedule 1, 2, or 3 (2)
- 		B = Strategic Environmental Research and Development 			Program (SERDP) Chemical (7)
- 		C = Air Force Installation Restoration Program Chemical (10)
- 		D = Army Toxicity Summary Chemical (9)
- 		E = Non-Stockpile Chemical Warfare Substance (4)

- Chemical Priority List for AEGL Development

## Chemical Priority List for AEGL Development

- DOE	Department of Energy Subcommittee for Consequence Assessment
- 	SCAPA	and Protective Action (80)
- 		A = TEEL chemical with vapor pressure >3.2 mm (35)
- 		B = TEEL chemical with TEEL-3 <25 ppm (9)
- 		C = Lab List (9)
- 		E = Other TEEL chemicals (39)
- DOJ	Department of Justice Office of Justice Programs (23)
- 		A = "High" concern Toxic Industrial Material (TIM) (3)
- 		B = "Medium" concern TIM (19)
- 		C = "Low" concern TIM (10)
- DOT	Department of Transportation Emergency Response Guidebook (106)
- 		A = Department of Transportation Emergency Response 			Guidebook Isolation Table (46)
- 		B = Other ERG (50)
- 		C = Top 150 Hazardous Material transported by rail (31)

## Chemical Priority List for  AEGL Development

- EPA	Environmental Protection Agency (95)
- 		A =  Environmental Protection Agency Clean Air Act 112r  		(Risk Management Program) (10)
- 		B = CAAA 112b Chemical (Hazardous Air Pollutant) (40)
- 		B* = April 1, 1994 list submitted by OAQPS
- 		(HAP with current acute toxicity interest) (9)
- 		C = Environmental Protection Agency Superfund Chemical 		(24)
- 		D = EPA Extremely Hazardous Substance List (* = EHS solid 		with RTECS LC data) (8)
- 		E = CAAA 112r Proposed Update Chemical (16)
- 		F = Office of Pesticides Nomination (28)
- OSHA	Occupational Safety and Health Administration (43)
- 		A = OSHA Process Safety Management Chemical (38)
- 		B = OSHA nomination for current acute toxicity interest (6)

## Chemical Priority List for AEGL Development

- OTHER		C = Chemical Market Reporter list
- 		D = Dutch chemical list (36)
- 		F = French chemical list (8)
- 		G = German chemical list
- 		H = High Production Volume chemical challenge list
- 		I = Illinois chemical list
- 		J = New Jersey chemical list
- 		K = Korean chemical list (6)
- 		N = New York chemical list
- 		P = Active U. S. Pesticide ingredient chemical
- 		R = Russian chemical list (5)
- 		S = Seveso Annex III International Seveso Convention List

## AEGL Chemical Status

- Рекомендательные Уровни Острого Воздействия РУОВ Результаты

- STATUS		NUMBER OF CHEMICALS
- Final			25
- Interim			54
- Proposed		43
- Draft & Holding		15

- AEGL Chemical Priority (108 Chemicals)

## Final AEGL Chemicals (18)

- 1,2-Dimethyl hydrazine
- Arsine
- Propylene glycol dinitrate
- Agent GA (Tabun)
- Agent GB (Sarin)

- 1,1-Dimethyl hydrazine
- Methyl hydrazine
- Aniline
- Hydrogen Cyanide
- Phosgene
- Diborane

- HFC 134a
- Agent GD (Soman)
- Agent GF
- Agent VX
- Sulfur mustard

**National Academy of Sciences (Free) **_**Publications on-line of Final AEGLs:**_
- http://www.nap.edu/catalog/10043.html
- http://www.nap.edu/catalog/10522.html
- _[http://www.nap.edu/catalog/10672.html](http://www.nap.edu/catalog/10672.html)_
-  (nerve agents and sulfur mustard)

## Slide 13

## Interim AEGL Chemicals (48)

**Interim AEGL Chemicals (48)**

- Carbon tetrachloride
- Methanol
- 1,1,1-Trichloroethane
- Ethylene oxide
- Propylene imine
- Propylene oxide
- Trimethyl chlorosilane
- Dichlorodimethyl silane
- Trichloromethyl silane
- Isobutyronitrile
- Acrylic acid
- 2,6-Toluene diisocyanate
- Allyl amine
- Propionitrile
- Ethylene diamine
- Allyl alcohol

- Chloromethyl methyl ether
- Toluene
- Cyclohexylamine
- Phenol
- Furan
- trans-Crotonaldehyde
- Methacrylonitrile
- Tetrachloroethylene
- Ethyleneimine
- cis-1,2-Dichloroethylene
- cis-trans -1,2-Di-chloroethylene
- Hydrazine
- Boron trifluoride
- Tetranitromethane
- 2,4-Toluene diisocyanate
- HFE-7100

- Perchloromethyl mercaptan
- Methyl isocyanate
- Carbon monoxide
- cis-Crotonaldehyde
- Hydrogen chloride
- Hydrogen fluoride
- Fluorine
- Chlorine
- Hydrogen sulfide
- Uranium hexafluoride
- Chlorine trifluoride
- Phospine
- Chlorine dioxide
- Boron trichloride
- Nickel carbonyl
- Iron pentacarbonyl

**Proposed AEGL Federal Register Notices with Technical Support Document Links:**
- http://www.epa.gov/fedrgstr/EPA-TOX/2002/February/Day-15/
- http://www.epa.gov/fedrgstr/EPA-TOX/2000/December/Day-13/t31730.htm
- http://www.epa.gov/fedrgstr/EPA-TOX/2000/June/Day-23/
- http://www.epa.gov/fedrgstr/EPA-TOX/2001/May/Day-02/t11001.htm
- http://www.epa.gov/fedrgstr/EPA-TOX/2000/March/Day-15/t6397.htm
- http://www.epa.gov/fedrgstr/EPA-TOX/1997/October/Day-30/t28642.htm

## Proposed AEGL Chemicals (33)

- Acetone
- Chloroform
- N,N-Dimethylformamide
- Benzene
- Methyl mercaptan
- Vinyl chloride
- Carbon disulfide
- Acetone cyanohydrin
- Methyl ethyl ketone

- Trichloroethylene
- Monochloroacetic acid
- Peracetic acid
- Epichlorohydrin
- Acrolein
- Piperidine
- 1,4-Dioxane
- Xylenes
- Sulfur dioxide
- Titanium tetrachloride

- Ammonia
- Phosphorus trichloride
- Bromine
- Jet Fuels (JP5 & 8)
- Phosphorus oxychloride
- Hydrogen bromide
- Nitric oxide
- Nitric acid
- Nitrogen dioxide

**Proposed AEGL Chemicals (33)**

## Draft and Holding AEGL Chemicals (8)

- Methyl chloroformate
- Isopropyl chloroformate
- Propyl chloroformate

- Cyanogen chloride
- Acrylylchloride
- Sulfur tetrafluoride
- Arsenic Trichloride

- Methylene chloride
- Sulfur Trioxide
- Sulfuric acid
- Oleum

**Draft and Holding AEGL Chemicals (8)**

## Chemical Classes- Value of Chemical Classes Approach

- Utilize "universal" pharmacokinetic and pharmacodynamic information from chemical class chemicals
- Identify chemicals for which AEGLs may be developed together (including chemicals from differing classes, such as chemicals that release HCl upon hydrolysis).
- Provide a range of AEGL levels for purposes of developing chemical class personal monitors.
- Provide a chemical class approach to protective equipment, decontamination and other counter-terrorism activities related to toxic chemical release (DOJ approach).
- Present for local use a systematic concept of acute toxicity of chemical classes. Illustrate the universe of acutely toxic chemicals.
- Allow for inherently safer chemistry suggestions, based on substitution or modification of current practices.
- Provide suggestions for revision of existing regulatory chemical lists (eg RMP)
- Provide Risk Management options

## CHEMICAL CLASSES

- 473 AEGL CHEMICALS IN 66 CHEMICAL CATEGORIES
- ( ) = NUMBER OF CHEMICALS PER CATEGORY

- ACID HALIDES (28)
- ALCOHOLS (6)
- ALDEHYDES (8)
- ALUMINUM COMPOUNDS (1)
- AMIDES (6)
- AMINES (31)
- ANHYDRIDES (2)
- ANILINES (4)
- ANTIMONY COMPOUNDS (2+)
- ARSENIC COMPOUNDS (16)
- AZO (2)
- BARIUM COMPOUNDS (+)
- BERYLLIUM COMPOUNDS (+)
- BORON COMPOUNDS (5)
- BROMINE COMPOUNDS (5)
- CADMIUM COMPOUNDS (+)
- CARBAMATES (6)
- CHLORINE, INORGANIC (4)
- CHLOROSILANES (16)
- CHROMIUM COMPOUNDS (1+)
- COBALT COMPOUNDS (+)
- COPPER COMPOUNDS (+)
- EPOXIDES (6)
- ESTERS (12)
- ETHERS (17)

- FLUORINES, INORGANIC (7)
- GERMANIUM COMPOUNDS (1+)
- HALOGENS, INORGANIC (54)
- HYDRIDES (1)
- HYDROCARBONS, ALIPHATIC (10)
- HYDROCARBONS, AROMATIC (14)
- IMINES (2)
- INORGANIC ACIDS (12)
- ISOCYANATES (14)
- KETONES (10)
- LEAD COMPOUNDS (2+)
- MANGANESE COMPOUNDS (1+)
- MERCAPTANS (6)
- MERCURY COMPOUNDS (4+)
- METAL CARBONYLS (2)
- NICKEL COMPOUNDS (1+)
- NITRILES (19)
- NITRO COMPOUNDS (7)
- NITROGEN COMPOUNDS, INORG (8)
- NITROSO (1)
- ORGANIC ACIDS (9)
- OSMIUM COMPOUNDS (1)

- OXIMES (1)
- OXYGEN COMPOUNDS, INORG (2)
- PEROXIDES (3)
- PHENOLS (10)
- PHOSPHATE & THIOPHOSPHATES  (24)
- PHOSPHONATE ESTERS (7)
- PHOSPHORAMIDATES (2)
- PHOSPHORUS COMPNDS, OTHER (16)
- SELENIUM COMPOUNDS (2)
- SILICON COMPOUNDS (2)
- SULFUR COMPOUNDS (20)
- TANTALUM COMPOUNDS (1)
- TELLURIUM COMPOUNDS (1)
- TETRACYCLIC COMPOUNDS (1)
- THALLIUM COMPOUNDS (1)
- TITANIUM COMPOUNDS (3)
- TUNGSTEN COMPOUNDS (1)
- VANADIUM COMPOUNDS (+)
- ZINC COMPOUNDS (+)

## Nitriles Chemical Class (AEGL-3, 2, 1 60 min) R1)(R2)(H) – C – C – (CN)(R4)(R5)

- Hydrogen cyanide (RMP) (for comparison) AEGL 3, 2, 1 (60 min) = 15, 7.1, 2.0 ppm
- Acetonitrile
- Acetone cyanohydrin AEGL 3, 2, 1 (60 min) = 15, 5.4, 0.84 ppm
- Isobutyronitrile (RMP) AEGL 3, 2, 1 (60 min) = 20, 6,6, NR ppm
- Lactonitrile
- Propionitrile (RMP) AEGL 3, 2, 1 (60 min)  = 39, 7.4, NR ppm
- Acrylonitrile (RMP)
- Chloroacetonitrile
- Formaledehyde cyanohydrin
- Malononitrile
- Methacrylonitrile (RMP) AEGL 3, 2, 1 (60 min) = 3.4, 1.1, NR ppm
- Sodium cyanide (for comparison)
- Cyanogen
- Cyanogen bromide
- Cyanogen chloride (RMP)
- Cyanogen iodide
- O-Chlorobenzylidene malononitrile
- Bromobenzyl cyanide