# Presentation: 735999

## Computing and CommunicationsandBiology

- Molecular Communication; Biological Communications Technology WorkshopArlington, VA20 February 2008

*Jeannette M. Wing*Assistant DirectorComputer and Information Science and Engineering Directorate

## CISE and NSF-wide Activities

- CISE Directorate
- Computer and Communications Foundations (CCF) – Michael Foster
- Information and Intelligent Systems (IIS)
- Signaling and Networking
- Computational Neuroscience
- Networks-in-the-Large
- Bioinformatics
- BIO Directorate
- Computational Thinking and Biology

## Signaling and Networking

- Nucleic acid signaling for computation and in vivo network control expression
- Structure elucidation and prediction ofcellular communication channels
- Structure of ion channel gating proteins
- Biological network prediction andcontrol element identification
- Nanotube communication systems and sensors
- Coding by molecules for control in computing and biological systems

- Credit: University of new Mexico

- Credit: Nature.com

## Computational Neuroscience

- Neural basis for word recognition
- Data sharing collaborative neuroscience
- Neural code of vision and the visual brain
- Statistical models of brain
- Neural basis of novelty recognition
- Evolutionary studies of biological network  complexity
- Gene/protein expression analysis in brain
- Recognition of mood, attitude, relationship in groups
- Biological basis of language

**Collaborative Research in Computational Neuroscience**
**(CRCNS; NSF 08-514): joint program with NIH**

- Credit: Wikimedia

- Credit: Nature.com

## Networks-in-the-Large

- Social network analysis for identifying communication patterns and key individuals in humans and other animals
- Food web signally analysis in ecological systems

- Credit: San Francisco State University

## BIO Directorate

- “Biology is an Information Science” – Dr. Jim Collins, BIO AD
- Molecular and Cellular Biology (MCB)
- Cellular Systems Cluster
- Signal Transduction Panel
- Example interest: Role of communication in natural communities of microbes, e.g., those associated in sponges, marine snow, in soils, to understand the interacting gene networks in such systems.

## National Academies(CSTB and DEPS) Study 2005

- National Academies(CSTB and DEPS) Study 2005

## Computational Thinking and Biology

- Computer Science in Biology   - Shotgun algorithm expedites sequencing     of human genome    - DNA sequences are strings in a language    - Protein structures can be modeled as knots    - Protein kinetics can be modeled as computational processes    - Cells as a self-regulatory system are like electronic circuits

- Credit: Wikimedia

## Credits

- Copyrighted material used under Fair Use.  If you are the copyright holder and believe your material has been used unfairly, or if you have any suggestions, feedback, or support, please contact: jsoleil@nsf.gov
- Except where otherwise indicated, permission is granted to copy, distribute, and/or modify all images in this document under the terms of the GNU Free Documentation license, Version 1.2 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts.  A copy of the license is included in the section entitled “GNU Free Documentation license” (_[http://commons.wikimedia.org/wiki/Commons:GNU_Free_Documentation_License](http://commons.wikimedia.org/wiki/Commons:GNU_Free_Documentation_License)_)