# Presentation: 760147

## Methadone Mortality – A Reassessment  

**Methadone Mortality – A Reassessment****  **

- Source:  ARCOS
- Date Prepared:   07/19/2007

- Drug Enforcement Administration, Office of Enforcement Operations, Pharmaceutical Investigations Section, Targeting and Analysis Unit

## Methadone Distribution*2000 – 2007** 

**Methadone**** Distribution*****2000 – 2007** **

**GRAMS PER 100K POPULATION**

*** Includes NTPs**

- Source:  ARCOS
- Date Prepared:   07/19/2007

- Drug Enforcement Administration, Office of Enforcement Operations, Pharmaceutical Investigations Section, Targeting and Analysis Unit

**** 01/01/2007 – 03/31/2007**

## Methadone PrescriptionsSource: IMS Health Prescription Audit

**Millions**

- DEA/OD                                                                                                                                                        04/2007

## Methadone Distribution*2000 – 2007** 

**GRAMS PER 100K POPULATION**

- Source:  ARCOS
- Date Prepared:   07/19/2007

- Drug Enforcement Administration, Office of Enforcement Operations, Pharmaceutical Investigations Section, Targeting and Analysis Unit

**N/A      +22% Chg  +16% Chg +21% Chg  + 20% Chg ****+9% Chg    +11% Chg     ****N/A **

*** Includes NTPs**

**** 01/01/2007 – 03/31/2007**

## Methadone Distribution*2000 – 2007**

**GRAMS PER 100K POPULATION**

- Source:  ARCOS
- Date Prepared:   07/19/2007

- Drug Enforcement Administration, Office of Enforcement Operations, Pharmaceutical Investigations Section, Targeting and Analysis Unit

**N/A      +22% Chg  +16% Chg +21% Chg  + 20% Chg ****+9% Chg    +11% Chg  ****+6% Chg **

*** Includes NTPs**

**** Projected**

## Comparison of Select Opioid Drugs2000 – 2007**

- Comparison of Select Opioid Drugs2000 – 2007**

**GRAMS PER 100K POPULATION**

- Source:  ARCOS
- Date Prepared:   07/19/2007

- Drug Enforcement Administration, Office of Enforcement Operations, Pharmaceutical Investigations Section, Targeting and Analysis Unit

*** Includes NTPs**

**** 01/01/2007 – 03/31/2007**

## Total PrescriptionsSelected Narcotic AnalgesicsSource: IMS Health Prescription Audit

**Note:  In 2006, there were about 35-fold more hydrocodone prescriptions and 10-fold more oxycodone prescriptions compared to methadone prescriptions.**

**Millions of Prescriptions**

## 2007**

**** 01/01/2007 – 03/31/2007**

## Methadone Distribution*Top 10 States, January – March, 2007

- Methadone Distribution*Top 10 States, January – March, 2007

**GRAMS PER 100K POPULATION**

*** Includes NTPs**

- Source:  ARCOS
- Date Prepared:   07/19/2007

- Drug Enforcement Administration, Office of Enforcement Operations, Pharmaceutical Investigations Section, Targeting and Analysis Unit

**Maine**

**Rhode Island**

**Oregon**

**Connecticut**

**Nevada**

**West Virginia**

**Florida**

**Maryland**

**District of Columbia**

**Washington**

**United States**

## Methadone Distribution*Top 10 States, January – March, 2007

**GRAMS PER 100K POPULATION**

*** Excludes NTPs**

- Source:  ARCOS
- Date Prepared:   07/19/2007

- Drug Enforcement Administration, Office of Enforcement Operations, Pharmaceutical Investigations Section, Targeting and Analysis Unit

**Oregon**

**Louisiana**

**Nevada**

**Washington**

**Alaska**

**Maine**

**Alabama**

**New**
**Hampshire**

**Florida**

**Utah**

**United States**

- Methadone Distribution*Top 10 States, January – March, 2007

## 2007** Purchases of Methadoneby Business Activity

**69 Practitioners**
**12,689 grams**
**0.4%**

**990 NTPs**
**1,876,767 grams**
**52.0%**

**2007** Purchases of ****Methadone****by Business Activity**

**4,262 Hospitals**
**145,651 grams**
**4.0%**

**1 Teaching Institution**
**1.32 grams**
**<0.1%**

**44,226 Pharmacies**
**1,573,492 grams**
**43.6%**

**0 Mid-Level Practitioners**
**0 grams**
**0.0%**

- Source:  ARCOS
- Date Prepared:   07/19/2007

- Drug Enforcement Administration, Office of Enforcement Operations, Pharmaceutical Investigations Section, Targeting and Analysis Unit

**** 01/01/2007 – 03/31/2007**

## Methadone Distribution* Per 100,000 Population 

**WA**

**OR**

**MT**

**ID**

**WY**

**ND**

**SD**

**MN**

**IA**

**NE**

**WI**

**MI**

**CO**

**KS**

**MO**

**IL**

**IN**

**UT**

**NV**

**CA**

**AZ**

**NM**

**OK**

**TX**

**AK**

**AR**

**LA**

**TN**

**KY**

**MS**

**AL**

**GA**

**SC**

**NC**

**OH**

**VA**

**PA**

**NY**

**ME**

**V**

**T**

**CT**

**N**

**J**

**MD**

**RI**

**DC**

**DE**

**HI**

**V**

**W**

**FL**

**MA**

**H**

**N**

**PR**

**Methadone**** ****Distribution* Per 100,000 Population**** **
**January - March, 2007**

**U.S. Average = 1,299 grams**

**Above Average = 1,625 grams or more**
**Average = 974 – 1,624 grams**
**Below Average = 973 grams or less**

- Source:  ARCOS
- Date Prepared:   07/19/2007

- Drug Enforcement Administration, Office of Enforcement Operations, Pharmaceutical Investigations Section, Targeting and Analysis Unit

- * Includes NTPs

**Notes:**
FLORIDA RANKED 15TH NATIONWIDE IN HYDROCODONE CONSUMPTION WITH A TOTAL OF 3,790 GRAMS PER 100K POPULATION.

## 2006

## Methadone Distribution*Top 10 States, January – December, 2006

- Methadone Distribution*Top 10 States, January – December, 2006

**GRAMS PER 100K POPULATION**

*** Includes NTPs**

- Source:  ARCOS
- Date Prepared:   07/19/2007

- Drug Enforcement Administration, Office of Enforcement Operations, Pharmaceutical Investigations Section, Targeting and Analysis Unit

**Maine**

**Rhode Island**

**Connecticut**

**Nevada**

**Oregon**

**District of Columbia**

**West**
**Virginia**

**Maryland**

**Florida**

**Washington**

**United States**

## Methadone Distribution*Top 10 States, January – December, 2006

- Methadone Distribution*Top 10 States, January – December, 2006

**GRAMS PER 100K POPULATION**

*** Excludes NTPs**

- Source:  ARCOS
- Date Prepared:   07/19/2007

- Drug Enforcement Administration, Office of Enforcement Operations, Pharmaceutical Investigations Section, Targeting and Analysis Unit

**Oregon**

**Louisiana**

**Nevada**

**Washington**

**Alaska**

**Maine**

**Alabama**

**New**
**Hampshire**

**Florida**

**Utah**

**United States**

## 2006 Purchases of Methadoneby Business Activity

**111 Practitioners**
**50,987 grams**
**0.4%**

**1,076 NTPs**
**7,347,950 grams**
**53.9%**

- 2006 Purchases of Methadoneby Business Activity

**5,688 Hospitals**
**581,326 grams**
**4.3%**

**4 Teaching Institutions**
**8.84 grams**
**<0.1%**

**49,804 Pharmacies**
**5,660,613 grams**
**41.5%**

**0 Mid-Level Practitioners**
**0 grams**
**0.0%**

- Source:  ARCOS
- Date Prepared:   07/19/2007

- Drug Enforcement Administration, Office of Enforcement Operations, Pharmaceutical Investigations Section, Targeting and Analysis Unit

## Methadone Distribution* Per 100,000 Population 

**January - December, 2006**

**U.S. Average = 4,911 grams**

**Above Average = 6,140 grams or more**
**Average = 3,683 – 6,139 grams**
**Below Average = 3,682 grams or less**

- Source:  ARCOS
- Date Prepared:   07/19/2007

- Drug Enforcement Administration, Office of Enforcement Operations, Pharmaceutical Investigations Section, Targeting and Analysis Unit

- * Includes NTPs

**Notes:**
FLORIDA RANKED 15TH NATIONWIDE IN HYDROCODONE CONSUMPTION WITH A TOTAL OF 3,790 GRAMS PER 100K POPULATION.

## Slide 18

## Methadone Distribution* 2000 – 2007** 

**Methadone**** Distribution* ****2000 – 2007** **

**GRAMS PER 100K POPULATION**

- Source:  ARCOS
- Date Prepared:   07/19/2007

- Drug Enforcement Administration, Office of Enforcement Operations, Pharmaceutical Investigations Section, Targeting and Analysis Unit

*** Includes NTPs**

**** 01/01/2007 – 03/31/2007**

## Methadone Distribution* 2000 – 2007** 

**GRAMS PER 100K POPULATION**

- Methadone Distribution* 2000 – 2007**** **

- Source:  ARCOS
- Date Prepared:   07/19/2007

- Drug Enforcement Administration, Office of Enforcement Operations, Pharmaceutical Investigations Section, Targeting and Analysis Unit

*** Includes NTPs**

**** 01/01/2007 – 03/31/2007**

## Methadone Distribution* 2000 – 2007** 

**GRAMS PER 100K POPULATION**

- Methadone Distribution* 2000 – 2007**** **

- Source:  ARCOS
- Date Prepared:   07/19/2007

- Drug Enforcement Administration, Office of Enforcement Operations, Pharmaceutical Investigations Section, Targeting and Analysis Unit

*** Includes NTPs**

**** Projected**

## Methadone Distribution* 2000 – 2007** 

**GRAMS PER 100K POPULATION**

- Methadone Distribution* 2000 – 2007**** **

- Source:  ARCOS
- Date Prepared:   07/19/2007

- Drug Enforcement Administration, Office of Enforcement Operations, Pharmaceutical Investigations Section, Targeting and Analysis Unit

*** Includes NTPs**

**** 01/01/2007 – 03/31/2007**

## Methadone Distribution* 2000 – 2007** 

**GRAMS PER 100K POPULATION**

- Methadone Distribution* 2000 – 2007**** **

- Source:  ARCOS
- Date Prepared:   07/19/2007

- Drug Enforcement Administration, Office of Enforcement Operations, Pharmaceutical Investigations Section, Targeting and Analysis Unit

*** Includes NTPs**

**** Projected**

## Methadone Distribution* 2000 – 2007** 

**GRAMS PER 100K POPULATION**

- Methadone Distribution* 2000 – 2007**** **

- Source:  ARCOS
- Date Prepared:   07/19/2007

- Drug Enforcement Administration, Office of Enforcement Operations, Pharmaceutical Investigations Section, Targeting and Analysis Unit

*** Includes NTPs**

**** 01/01/2007 – 03/31/2007**

## Methadone Distribution* 2000 – 2007** 

**GRAMS PER 100K POPULATION**

- Methadone Distribution* 2000 – 2007**** **

- Source:  ARCOS
- Date Prepared:   07/19/2007

- Drug Enforcement Administration, Office of Enforcement Operations, Pharmaceutical Investigations Section, Targeting and Analysis Unit

*** Includes NTPs**

**** Projected**

## 2007**

**** 01/01/2007 – 03/31/2007**

## Nationwide Distribution* of Methadonein 2007**

**40 mg Diskettes**
**855,699 grams**
**24%**

- Nationwide Distribution* of Methadonein 2007**

**All Other**
**158,218 grams**
**4%**

**Liquids**
**1,394,714 grams**
**39%**

**5 mg & 10 mg Tablets**
**1,199,969 grams**
**33%**

- Source:  ARCOS
- Date Prepared:   07/19/2007

- Drug Enforcement Administration, Office of Enforcement Operations, Pharmaceutical Investigations Section, Targeting and Analysis Unit

*** Includes NTPs**

**** 01/01/2007 – 03/31/2007**

## Nationwide Distribution of Methadoneto Practitioners in 2007**

- Nationwide Distribution of Methadoneto _Practitioners_ in 2007**

**All Other**
**4.47 grams**
**0.04%**

**Liquids**
**2.18 grams**
**0.02%**

- Source:  ARCOS
- Date Prepared:   07/19/2007

- Drug Enforcement Administration, Office of Enforcement Operations, Pharmaceutical Investigations Section, Targeting and Analysis Unit

**** 01/01/2007 – 03/31/2007**

## Nationwide Distribution of Methadoneto Hospitals in 2007**

**40 mg Diskettes**
**11,773 grams**
**8.1%**

**All Other**
**233 grams**
**0.2%**

**Liquids**
**11,009 grams**
**7.6%**

**5 mg & 10 mg Tablets**
**122,637 grams**
**84.2%**

- Source:  ARCOS
- Date Prepared:   07/19/2007

- Drug Enforcement Administration, Office of Enforcement Operations, Pharmaceutical Investigations Section, Targeting and Analysis Unit

- Nationwide Distribution of Methadoneto _Hospitals_ in 2007**

**** 01/01/2007 – 03/31/2007**

## Nationwide Distribution of Methadoneto Pharmacies in 2007**

**40 mg Diskettes**
**486,890 grams**
**30.9%**

**All Other**
**7,633 grams**
**0.5%**

**Liquids**
**14,636 grams**
**0.9%**

**5 mg & 10 mg Tablets**
**1,064,333 grams**
**67.6%**

- Source:  ARCOS
- Date Prepared:   07/19/2007

- Drug Enforcement Administration, Office of Enforcement Operations, Pharmaceutical Investigations Section, Targeting and Analysis Unit

- Nationwide Distribution of Methadoneto _Pharmacies_ in 2007**

**** 01/01/2007 – 03/31/2007**

## Nationwide Distribution of Methadoneto NTPs in 2007**

**40 mg Diskettes**
**346,782 grams**
**18.5%**

**All Other**
**150,349 grams**
**8.0%**

**Liquids**
**1,369,067 grams**
**72.9%**

**5 mg & 10 mg Tablets**
**10,569 grams**
**0.6%**

- Source:  ARCOS
- Date Prepared:   07/19/2007

- Drug Enforcement Administration, Office of Enforcement Operations, Pharmaceutical Investigations Section, Targeting and Analysis Unit

- Nationwide Distribution of Methadoneto _NTPs_ in 2007**

**** 01/01/2007 – 03/31/2007**

## Purchases of Methadone 40 mg Diskettes in 2007** by Business Activity

**36 Practitioners**
**10,253 grams**
**1%**

**355 NTPs**
**346,782 grams**
**41%**

- _Purchases of __Methadone 40 mg Diskettes_ in 2007** by Business Activity

**460 Hospitals**
**11,773 grams**
**1%**

**0 Teaching Institutions**
**0 grams**
**0%**

**0 Mid-Level Practitioners**
**0 grams**
**0%**

**14,651 Pharmacies**
**486,890 grams**
**57%**

- Source:  ARCOS
- Date Prepared:   07/19/2007

- Drug Enforcement Administration, Office of Enforcement Operations, Pharmaceutical Investigations Section, Targeting and Analysis Unit

**** 01/01/2007 – 03/31/2007**

## Purchases of Methadone 5 mg & 10 mg Tablets in 2007** by Business Activity

**54 Practitioners**
**2,429 grams**
**0.2%**

**204 NTPs**
**10,569 grams**
**0.9%**

**4,055 Hospitals**
**122,637 grams**
**10.2%**

**1 Teaching Institution**
**1.32 grams**
**<0.1%**

**0 Mid-Level Practitioners**
**0 grams**
**0.0%**

**43,243 Pharmacies**
**1,064,333 grams**
**88.7%**

- _Purchases of __Methadone 5 mg & 10 mg Tablets_ in 2007** by Business Activity

- Source:  ARCOS
- Date Prepared:   07/19/2007

- Drug Enforcement Administration, Office of Enforcement Operations, Pharmaceutical Investigations Section, Targeting and Analysis Unit

**** 01/01/2007 – 03/31/2007**

## Purchases of Methadone Liquids in 2007** by Business Activity

**4 Practitioners**
**2.18 grams**
**<0.1%**

**743 NTPs**
**1,369,067 grams**
**98.2%**

- _Purchases of __Methadone Liquids_ in 2007** by Business Activity

**1,088 Hospitals**
**11,009 grams**
**0.8%**

**0 Teaching Institutions**
**0 grams**
**0.0%**

**0 Mid-Level Practitioners**
**0 grams**
**0.0%**

**2,100 Pharmacies**
**14,636 grams**
**1.0%**

- Source:  ARCOS
- Date Prepared:   07/19/2007

- Drug Enforcement Administration, Office of Enforcement Operations, Pharmaceutical Investigations Section, Targeting and Analysis Unit

**** 01/01/2007 – 03/31/2007**

## 2006

## Nationwide Distribution* of Methadonein 2006

**40 mg Diskettes**
**3,252,591 grams**
**24%**

- Nationwide Distribution* of Methadonein 2006

**All Other**
**657,413 grams**
**5%**

**Liquids**
**5,311,031 grams**
**39%**

*** Includes NTPs**

**5 mg & 10 mg Tablets**
**4,419,850 grams**
**32%**

- Source:  ARCOS
- Date Prepared:   07/19/2007

- Drug Enforcement Administration, Office of Enforcement Operations, Pharmaceutical Investigations Section, Targeting and Analysis Unit

## Nationwide Distribution of Methadoneto Practitioners in 2006

- Nationwide Distribution of Methadoneto _Practitioners_ in 2006

**All Other**
**19 grams**
**0.04%**

**Liquids**
**23 grams**
**0.05%**

- Source:  ARCOS
- Date Prepared:   07/19/2007

- Drug Enforcement Administration, Office of Enforcement Operations, Pharmaceutical Investigations Section, Targeting and Analysis Unit

## Nationwide Distribution of Methadoneto Hospitals in 2006

**40 mg Diskettes**
**45,307 grams**
**7.8%**

**All Other**
**639 grams**
**0.1%**

**Liquids**
**60,783 grams**
**10.5%**

**5 mg & 10 mg Tablets**
**474,598 grams**
**81.6%**

- Source:  ARCOS
- Date Prepared:   07/19/2007

- Drug Enforcement Administration, Office of Enforcement Operations, Pharmaceutical Investigations Section, Targeting and Analysis Unit

- Nationwide Distribution of Methadoneto _Hospitals_ in 2006

## Nationwide Distribution of Methadoneto Pharmacies in 2006

**40 mg Diskettes**
**1,680,692 grams**
**29.7%**

**All Other**
**23,877 grams**
**0.4%**

**Liquids**
**58,128 grams**
**1.0%**

**5 mg & 10 mg Tablets**
**3,897,915 grams**
**68.9%**

- Source:  ARCOS
- Date Prepared:   07/19/2007

- Drug Enforcement Administration, Office of Enforcement Operations, Pharmaceutical Investigations Section, Targeting and Analysis Unit

- Nationwide Distribution of Methadoneto _Pharmacies_ in 2006

## Nationwide Distribution of Methadoneto NTPs in 2006

**40 mg Diskettes**
**1,481,873 grams**
**20.2%**

**All Other**
**632,878 grams**
**8.6%**

**Liquids**
**5,192,096 grams**
**70.7%**

**5 mg & 10 mg Tablets**
**41,103 grams**
**0.6%**

- Source:  ARCOS
- Date Prepared:   07/19/2007

- Drug Enforcement Administration, Office of Enforcement Operations, Pharmaceutical Investigations Section, Targeting and Analysis Unit

- Nationwide Distribution of Methadoneto _NTPs_ in 2006

## 2006 Purchases of Methadone 40 mg Diskettesby Business Activity

**58 Practitioners**
**44,718 grams**
**1%**

**424 NTPs**
**1,481,873 grams**
**46%**

**2006 Purchases of ****Methadone 40 mg Diskettes****by Business Activity**

**809 Hospitals**
**45,307 grams**
**1%**

**0 Teaching Institutions**
**0 grams**
**0%**

**0 Mid-Level Practitioners**
**0 grams**
**0%**

**19,278 Pharmacies**
**1,680,692 grams**
**52%**

- Source:  ARCOS
- Date Prepared:   07/19/2007

- Drug Enforcement Administration, Office of Enforcement Operations, Pharmaceutical Investigations Section, Targeting and Analysis Unit

## 2006 Purchases of Methadone 5 mg & 10 mg Tabletsby Business Activity

**96 Practitioners**
**6,228 grams**
**0.1%**

**264 NTPs**
**41,103 grams**
**0.9%**

**5,508 Hospitals**
**474,598 grams**
**10.7%**

**1 Teaching Institution**
**7.06 grams**
**<0.1%**

**0 Mid-Level Practitioners**
**0 grams**
**0.0%**

**49,077 Pharmacies**
**3,897,915 grams**
**88.2%**

**2006 Purchases of ****Methadone 5 mg & 10 mg Tablets****by Business Activity**

- Source:  ARCOS
- Date Prepared:   07/19/2007

- Drug Enforcement Administration, Office of Enforcement Operations, Pharmaceutical Investigations Section, Targeting and Analysis Unit

## 2006 Purchases of Methadone Liquidsby Business Activity

**6 Practitioners**
**23 grams**
**<0.1%**

**792 NTPs**
**5,192,096 grams**
**97.8%**

**2006 Purchases of ****Methadone Liquids****by Business Activity**

**1,981 Hospitals**
**60,783 grams**
**1.1%**

**0 Teaching Institutions**
**0 grams**
**0.0%**

**0 Mid-Level Practitioners**
**0 grams**
**0.0%**

**4,414 Pharmacies**
**58,128 grams**
**1.1%**

- Source:  ARCOS
- Date Prepared:   07/19/2007

- Drug Enforcement Administration, Office of Enforcement Operations, Pharmaceutical Investigations Section, Targeting and Analysis Unit

## Methadone Sales to Pharmacies in U.S.January 2002 – March 2007

- Source:  ARCOS
- Date Prepared:   07/19/2007

- Drug Enforcement Administration, Office of Enforcement Operations, Pharmaceutical Investigations Section, Targeting and Analysis Unit