# Presentation: 179424

## NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

## NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

**SMALL BUSINESS **
**RESEARCH  OPPORTUNITIES**
**PHYLLIS MITCHELL**
**NATIONAL HEART, LUNG AND  BLOOD**
**DIVISION BLOOD DISEASES AND RESOURCES**
**(301)435-0481****	****	****	****	****FAX:  (301)480-1060**
**MITCHELP@NHLBI.NIH.GOV**

## NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

**The NHLBI SBIR/STTR program fosters research on:**
**Pharmaceuticals**
**Medical Devices and Implants**
**Biologics**
**Informatics**
**Biotechnologies**
**for the causes, prevention, diagnosis and treatment of heart, blood vessel, lung, blood diseases and sleep disorders.**

##  NHLBI Extramural Divisions

- <date/time>

-  **NHLBI Extramural Divisions**

**  ****Division of Heart and Vascular Diseases**
**  ****Div. of Epidemiology and Clinical Applications**
**  ****Division of Lung Diseases**
**  ****Division of  Blood Diseases and Resources**
**  ****National Center on Sleep Disorders Research**

## NHLBI SBIR Home Pagehttp://www.nhlbi.nih.gov/funding/sbir/index.htm   NHLBI Mission Statement   Staff Contacts   NIH Omnibus   Notices   NHLBI Topics   Model SBIR Application

- <date/time>

**NHLBI SBIR Home Page****http://www.nhlbi.nih.gov/funding/sbir/index.htm****   NHLBI Mission Statement****   Staff Contacts****   NIH Omnibus****   Notices****   NHLBI Topics****   Model SBIR Application**

## Examples of Awarded Projects

- <date/time>

- Improved Hollow Fibers for Intravenous Blood Oxygenators
- Gene Delivery Systems for Broncho-Alveolar Diseases
- Novel Ex Vivo Expansion of Cord Blood Progenitors
- Automated Quantitation of 3D Echocardiograms
- Coated Electrosurgical Blade

## Examples of Awarded Projects

- <date/time>

- Automated Process for a Tissue Engineered Blood
- Antisense Therapeutics for Treatment of Cyctic Fibrosis
- Improved Vectors for Therapeutic Protein Production
- Intraluminal Robot Assisted Mitral Valve Repair
- An Expert System to Improve Medication Adherence

## VISIT THE NATIONAL INSTITUTES OF HEALTH SMALL BUSINESS FUNDING OPPORTUNITIES WEBSITE http://grants.nih.gov/grants/funding/sbir.htm  

- <date/time>

**VISIT THE ****NATIONAL INSTITUTES OF HEALTH**** SMALL BUSINESS FUNDING OPPORTUNITIES WEBSITE**** ****http://grants.nih.gov/grants/funding/sbir.htm**** **

**SPECIAL ANNOUNCEMENTS FOR**
**SMALL BUSINESS RESEARCH PROJECTS**
**http://grants.nih.gov/grants/funding/sbir_announcements.htm**

**Notes:**
At the last meeting on April 27, 2000, I reported that the
Grants Team was meeting weekly to evaluate 214 comments  
received from various Federal agencies on the Grants
Exposure Draft.

The Team had 83 comments remaining to be addressed at that
time.  The Team met on April 27 and May 4, 2000, and
completed the review process.

The next slide provides details on the final disposition of all 214
comments.  All comments have been addressed.  However, there
remains one policy issue to be resolved in the future, on the
three payment systems standardization.

## TECHNOLOGIES TO IMPROVE THE UTILITY OF ANIMAL MODELS  This Program Announcement encourages the small business community to develop technologies, reagents, and equipment to improve the utility of animal models for biomedical research  http://grants.nih.gov/grants/guide/pa-99-048.html

- <date/time>

**TECHNOLOGIES TO IMPROVE THE UTILITY OF ANIMAL MODELS **** ****This Program Announcement encourages the small business community to develop technologies, reagents, and equipment to improve the utility of animal models for biomedical research**** **** http://grants.nih.gov/grants/guide/pa-99-048.html**

**Notes:**
At the last meeting on April 27, 2000, I reported that the
Grants Team was meeting weekly to evaluate 214 comments  
received from various Federal agencies on the Grants
Exposure Draft.

The Team had 83 comments remaining to be addressed at that
time.  The Team met on April 27 and May 4, 2000, and
completed the review process.

The next slide provides details on the final disposition of all 214
comments.  All comments have been addressed.  However, there
remains one policy issue to be resolved in the future, on the
three payment systems standardization.

## Examples of Awarded Projects

- <date/time>

- Rat Models to Screen Compounds Inducing Slow Wave Sleep
- Development of a Transgenic Rat Atherosclerosis Model
- Tools and Techniques to Measure Blood Flow and Pressure in Mice
- Development of Microimaging Techniques for use in  Small Animals
- Opitimization of Rodent Models of Transplant CAD

## Slide 11

## STUDY AND CONTROL OF MICROBIAL BIOFILMS  This Program Announcement is designed to support the development of technologies and strategies for the prevention and treatment of microbial biofilm-associated diseases. http://grants.nih.gov/grants/guide/pa-99-084.html

- <date/time>

**STUDY AND CONTROL OF MICROBIAL BIOFILMS**** **** ****This Program Announcement is designed to support the development of technologies and strategies for the prevention and treatment of microbial biofilm-associated diseases.**** ****http://grants.nih.gov/grants/guide/pa-99-084.html**

**Notes:**
At the last meeting on April 27, 2000, I reported that the
Grants Team was meeting weekly to evaluate 214 comments  
received from various Federal agencies on the Grants
Exposure Draft.

The Team had 83 comments remaining to be addressed at that
time.  The Team met on April 27 and May 4, 2000, and
completed the review process.

The next slide provides details on the final disposition of all 214
comments.  All comments have been addressed.  However, there
remains one policy issue to be resolved in the future, on the
three payment systems standardization.

## Examples of Research Topics

- <date/time>

- Development of Improved Imaging of Biofilms in situ
- Development of systems for the Study of Biofilm-Specific Gene Expression & Exchange of Genetic Material within Biofilms
- Development of Mathematical Models & Computer Simulations of Biofilms
- Techniques or Assays for Studies of Host Immune Responses

## Examples of Research Topics

- <date/time>

- Technologies to Enhance the Sensitivity of Biofilms to Antimicrobial Agents
- Technologies for Studies of Pathogenic Mechanisms of Microbes Growing in Biofilms
- Technologies and Materials Relevant to the Interaction of Biofilms with Host Tissues and Artificial Implants

## Slide 15

## PROTEIN STRUCTURE INITIATIVE (STRUCTURAL GENOMICS)  The purpose of this  Program Announcement is to encourage research on the development of methodology and technology underpinning the emerging field of structural genomics, whose goal is the understanding of protein structural families, structural folds, and the relation of structure and function. http://grants.nih.gov/grants/guide/pa-files/pa-99-117.html

- <date/time>

**PROTEIN STRUCTURE INITIATIVE ****(STRUCTURAL GENOMICS) **** ****The purpose of this  Program Announcement is to encourage research on the development of methodology and technology underpinning the emerging field of structural genomics, whose goal is the understanding of protein structural families, structural folds, and the relation of structure and function.**** http://grants.nih.gov/grants/guide/pa-files/pa-99-117.html**

**Notes:**
At the last meeting on April 27, 2000, I reported that the
Grants Team was meeting weekly to evaluate 214 comments  
received from various Federal agencies on the Grants
Exposure Draft.

The Team had 83 comments remaining to be addressed at that
time.  The Team met on April 27 and May 4, 2000, and
completed the review process.

The next slide provides details on the final disposition of all 214
comments.  All comments have been addressed.  However, there
remains one policy issue to be resolved in the future, on the
three payment systems standardization.

## Examples of Research Topics

- <date/time>

- Development of Methods:
- for selecting representative protein families based on enhancement of structure space coverage or functional significance.
- for high throughput production of target proteins suitable for structure determination
- for high throughput data collection

## Examples of Research Topics

- <date/time>

- Development of Methods:
- for automated determination, validation and analysis of 3D structures.
- for homology-based modeling, related methods, and validation of modeled structures
- for informatics systems to optimize & support the process of structure determination

## Slide 19

## BIOENGINEERING NANOTECHNOLOGY INITIATIVE  This Program Announcement, issued as an initiative of the trans-NIH Bioengineering Consortium (BECON), invites grant applications for Small Business projects on nanotechnologies useful to biomedicine. http://grants.nih.gov/grants/guide/pa-files/pa-00-018.html

- <date/time>

**BIOENGINEERING NANOTECHNOLOGY INITIATIVE **** ****This Program Announcement, issued as an initiative of the trans-NIH Bioengineering Consortium (BECON), invites grant applications for Small Business projects on nanotechnologies useful to biomedicine.**** http://grants.nih.gov/grants/guide/pa-files/pa-00-018.html**

**Notes:**
At the last meeting on April 27, 2000, I reported that the
Grants Team was meeting weekly to evaluate 214 comments  
received from various Federal agencies on the Grants
Exposure Draft.

The Team had 83 comments remaining to be addressed at that
time.  The Team met on April 27 and May 4, 2000, and
completed the review process.

The next slide provides details on the final disposition of all 214
comments.  All comments have been addressed.  However, there
remains one policy issue to be resolved in the future, on the
three payment systems standardization.

## Examples of Research Topics

- <date/time>

- Nanoplumbing components....Valves microfluidic channels, motors...that can be operated from a distance.
- Logic Circuits....based on quantum dots which carry out computing functions without current flow
- Fluorescent probes at nanometer scale for monitoring biochemical processes on the surface and inside the cell

## Examples of Research Topics

- <date/time>

- Nanofabricated barriers to control rejection of implantable materials
- Nanoparticles and nanospheres that enable controlled release of therapeutic agents, antibodies, genes and vaccines
- Biotemplates and sensor technologies for detection and analysis of DNA  and RNA targets in body fluid samples
- “Smart” nanostructured biocompatible materials

## http://grants.nih.gov/grants/guide/pa-files/pa-00-018.html

- BIOENGINEERING NANOTECHNOLOGY INITIATIVE
- PA NUMBER:  PA-00-018 	Release Date:  December 2, 1999
- National Cancer Institute
- National Center for Research Resources
- National Eye Institute
- National Human Genome Research Institute
- National Heart, Lung, and Blood Institute
- National Institute on Aging
- National Institute on Alcohol Abuse and Alcoholism
- National Institute of Allergy and Infectious Diseases
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- National Institute of Child Health and Human Development
- National Institute on Drug Abuse
- National Institute on Deafness and Other Communication Disorders
- National Institute of Dental and Craniofacial Research
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Environmental Health Sciences
- National Institute of General Medical Sciences
- National Institute of Mental Health
- National Institute of Neurological Disorders and Stroke
- National Library of Medicine
-  APPLICATION RECEIPT DATES:  April 1, August 1, and December 1 in the years 2000, 2001, and 2002.

## NHLBI Contacts

- <date/time>

**NHLBI Contacts**

**Heart and Vascular Disease**
-     Dr. John T. Watson     watsonj@nhlbi.nih.gov
- 	(301) 435-0513		Fax:  (301) 480-1336
- 	Dr. Rosalie Dunn     dunnr@nhlbi.nih.gov
-     (301) 435-0505		Fax:  (301) 480-1454
**Lung Diseases**
- Dr. Robert Musson     mussonr@nhlbi.nih.gov
- (301) 435-0222		Fax:  (301) 480-3557
- Ms. Ann Rothgeb     rothgeba@nhlbi.nih.gov
- (301) 435-0202		Fax:  (301) 480-3557

## NHLBI Contacts

- <date/time>

**NHLBI Contacts**

**Blood Diseases and Resources**
- Ms. Susan Pucie           Pucies@nhlbi.nih.gov
- (301) 435-0079		Fax:  (301) 480-0867
**Epidemiology and Clinical Applications**
- Dr. Thomas Blaszkowski  blaszkot@nhlbi.nih.gov
- (301) 435-0417		Fax:  (301) 480-1864
**Administrative and Business Management**
- Mr. Ed Donohue     donohuee@nhlbi.nih.gov
- (301) 435-0144		Fax:  (301) 480-3310

## REMEMBER

- <date/time>

**REMEMBER**

**NHLBI Staff are enthusiastic about hearing your ideas and providing advice**
**In addition to Your good ideas:  Check the Websites for Research Topics**
**Write that Quality Scientific Grant**
**NHLBI wants to do Business with YOU**