# Presentation: 520884

## Influenza Vaccine Responses 

**Roland A. Levandowski, M.D.**
**Division of Viral Products**

**Prepared for **
**Vaccines and Related Biological **
**Products Advisory Committee**
**16-17 February 2005**

## Serum Panels for Serologies

**	****WHO, AUSTRALIA****	****ELDER****	****A/WYOMING/3/2003  (H3N2) **
**	****	****	****	****	****B/BRISBANE/32/2002**
** **
**2. ****	****JOHN WOOD, PH.D****	****ADULT****	****A/NEW CALEDONIA/20/99  (H1N1) **
**	****NIBSC, ENGLAND****	****ELDER****	****A/WYOMING/3/2003  (H3N2) **
**	****	****	****	****	****B/JIANGSU/10/2003**
** **
**3. TAKATO ODIGARI, PH.D. ****	****ADULT****	****A/NEW CALEDONIA/20/99-LIKE  (H1N1) **
**	****WHO, JAPAN****	****	****ELDER****	****A/WYOMING/3/2003  (H3N2) **
**	****	****	****	****	****B/SHANGHAI/361/2003**

## Serum Panels for Serologies

** ****	**** **
**4. ****	****STEFAN GRAVENSTEIN, M.D.****	****ADULT****	****A/NEW CALEDONIA/20/99 (H1N1) **
**	****EASTERN VIRGINIA ****	****	****ELDER****	****A/WYOMING/3/2003 (H3N2)**
**	****MEDICAL SCHOOL****	****	****CHILD****	****B/JIANGSU/10/2003****	**
** **
**5.****	****WILLIAM KOCH, M.D.****	****	****CHILD****	****A/NEW CALEDONIA/20/99 (H1N1)**
**	****VIRGINIA COMMONWEALTH****	****	****A/WYOMING/3/2003**
**	****UNIVERSITY****	****	****	****	****B/JIANGSU/10/2003 **

## ANTIGENS FOR SEROLOGIES (H1)

**VACCINE STRAIN**
**	****A/NEW CALEDONIA/20/99 (H1N1)**
**REPRESENTATIVE CURRENT STRAINS**
**	****A/BANGKOK/1544/2004 (H1N1)**
**	****A/FLORIDA/4/2004 (H1N1)**
**	****A/NETHERLANDS/128/2004 (H1N1)**
**	****A/NEW CALEDONIA/9/2004 (H1N1)**
**	****A/OKINAWA/42/2004 (H1N1)**
**	****A/SAITAMA/78/2004 (H1N1)**
**	****A/SINGAPORE/14/2004 (H1N1)**

## HI ANTIBODY RESPONSES TO THE H1 COMPONENT2004-2005 INFLUENZA VACCINEADULT POPULATION (CBER)

## HI ANTIBODY RESPONSES TO THE H1 COMPONENT2004-2005 INFLUENZA VACCINEELDERLY POPULATION (NIBSC)

## HI ANTIBODY RESPONSES TO THE H1 COMPONENT2004-2005 INFLUENZA VACCINEPEDIATRIC POPULATION (CDC AND CBER)

## A/NEW CALEDONIA/20/99 VACCINESSUMMARY TABLEVIRUSES WITH > 50% GMT REDUCTION

## ANTIGENS FOR SEROLOGIES (H3)

**VACCINE STRAIN**
**	****A/WYOMING/3/2003**
**REPRESENTATIVE CURRENT STRAINS**
**	****A/BANGKOK/1563/2004**
**	****A/CALIFORNIA/7/2004**
**	****A/OSAKA/36/2004**
**	****A/OSLO/8/2004****	****	**
**	****A/SHANTOU/1219/2004**
**	****A/SINGAPORE/36/2004**
**	****A/SINGAPORE/37/2004**
**	****A/TENNESSEE/6/2004**
**	****A/TOKYO/1035/2004**
**	****A/VICTORIA/523/2004**

## HI ANTIBODY RESPONSES TO THE H3 COMPONENT2004-2005 INFLUENZA VACCINEADULT POPULATION ( CDC )

## HI ANTIBODY RESPONSES TO THE H3 COMPONENT2004-2005 INFLUENZA VACCINEELDERLY POPULATION (NIBSC)

## HI ANTIBODY RESPONSES TO THE H3 COMPONENT2004-2005 INFLUENZA VACCINEPEDIATRIC POPULATION (CDC AND CBER)

## A/WYOMING/3/2003 VACCINESSUMMARY TABLEVIRUSES WITH > 50% GMT REDUCTION

## ANTIGENS FOR SEROLOGIES (B)

**VACCINE STRAIN**
**	****B/BRISBANE/32/2002*****	****	**
**	****B/JIANGSU/10/2003+****	**
**REPRESENTATIVE CURRENT STRAINS**
**	****B/HAWAII/13/2004***
**	****B/PHITSANULOK/2053/2004***
**	****B/COLORADO/4/2004+**
**	****B/FLORIDA/7/2004+**
**	****B/FUJIAN/430/2004+****	****	***** = HONG KONG/330-LIKE**
**	****B/LISBON/1/2004+****	****	****+ = SHANGHAI/361-LIKE**
**	****B/SHIZUOKA/2/2004+**
**	****B/SHIZUOKA/58/2004+**
**	****B/VICTORIA/501/2004+**

## HI ANTIBODY RESPONSES TO THE B COMPONENT2004-2005 INFLUENZA VACCINEADULT POPULATION (CDC)

## HI ANTIBODY RESPONSES TO THE B COMPONENT2004-2005 INFLUENZA VACCINEELDERLY POPULATION (AUS)

## HI ANTIBODY RESPONSES TO THE B COMPONENT2004-2005 INFLUENZA VACCINEPEDIATRIC POPULATION (CDC AND CBER)

## B/SHANGHAI/361/2002-LIKE VACCINESSUMMARY TABLEVIRUSES WITH > 50% GMT REDUCTION

## Influenza Vaccine ResponsesSummary

- Studies with sera collected after immunization with current vaccines show that:
- Representative influenza A (H1N1) viruses are well-inhibited
- A/California/7/2004 (H3N2)-like viruses are poorly inhibited compared to the vaccine strain
- B/Shanghai/361/2002-like viruses are reasonably well-inhibited but B/Hong Kong/330/2001-like viruses are less well inhibited than the vaccine strains