BEE-spoke-data/govdocs1-by-extension huggingface dataset:
# Presentation: 017572

## Air Force and CAPCore Values

## Air Force and CAPCore Values

-  Integrity
-  Integrity is a character trait.  It is the willingness to do what is right even when no one is looking.
-  Volunteer Service
-  Voluntarily giving of oneself, over personal desires, to provide for the welfare of others.

## Air Force and CAP Core Values

-  Excellence
-  Challenges us to develop a sustained passion for continuous improvement and innovation to enable the CAP to grow and flourish in serving America’s humanitarian needs.
-  Respect
-  Means we value our diverse membership. We treat each other with fairness, dignity, and compassion. We work as a team.* *
-  George Washington

## Core Values In Action

-  Capt Lance P. Sijan
- POW in Vietnam and Medal of Honor Recipient
- What Core Values exhibited?
- How would they apply today?

## Case Studies

-  Taking Leave
-  Tool Time
-  The Outburst

## Summary

-  Definitions
- Integrity
- Volunteer Service
- Excellence
- Respect
-  Core Values in Action
-  Case Studies
# Presentation: 186731

## Weapon System Explosives Safety Review BoardSoftware Systems Safety Technical Review Panel

- Douglas J. Bower
- NAVSEA Dahlgren
- Chairman

## Topics

- SSSTRP Background
- Review Criteria
- Areas of Particular Concern
- Summary

## SSSTRP Background

- Established by WSESRB in Aug 1991 to review safety programs for software only or software intensive systems
- Provide more thorough review than possible in regular WSESRB format
- Assemble technical experts to review the software safety program and products
- Reduces burden on WSESRB
- Focus needed attention on software

## Review Criteria

- Types of Review
- Meeting Review
- Data Package and Presentation
- Minimum of 3 government panel members
- Letter  Review
- Data Package Only
- Requires 3 government reviewers (except action item closure)
- When are SSSTRP reviews required?
- Functional/Design modification to software
- Changes to safety related software (STR fix)
- When are SSSTRP reviews NOT required?
- Changes to non-safety related software (STR fix)
- SSSTRP should be informed of changes, change scope, and new build number

## Areas of Particular Interest

- Interaction between safety program and system and software development
- Systems Engineering
- Software Engineering
- Software CM
- SCCB
- Change Review Board
- SQA
- Software Testing at all levels
- Code & Unit Test
- FQT
- System Integration

## Areas of Particular Interest

- Safety Organization
- Who and What
- Relationship with program office
- Generic Requirements
- STANAG 4404
- Ada MITRE Guidelines
- Safer “C”
- Standards and Directives
- Joint Software Systems Safety Handbook

## Areas of Particular Interest

- Operating Systems and Environments, Middleware
- Which are being used?
- Accessible by user?
- Sufficient isolation of safety critical components?
- Analysis and Test program
- Original Development
- Upgrades to O/S and O/E
- Configuration Management

## Areas of Particular Interest

- COTS and NDI
- What products are used
- Safety Criticality
- Analysis and test program
- Isolation from safety critical applications
- Configuration Management
- How are upgrades and changes evaluated
- Address throughout lifecycle

## Summary

- The SSSTRP provides a valuable resource and service to the WSESRB
- Not relied upon to extent possible
- Focuses needed attention on the potential risk of software in the system context
- Serves as a valuable resource to other services and countries

## Summary

- SSSTRP review process has resulted in:
- Development of new, innovative processes and techniques
- Higher quality and safer software in Navy applications
- Reviews have shown many areas requiring safety program guidance:
- Operating system and environment selection
- COTS/GOTS/NDI guidelines
- Language selection criteria
- Open Systems Architecture
- Firmware, FPGAs, ...
# Presentation: 728618

## J/’ in CuCu 200 GeVcorrected 2/10/05

**J/********’******************** in CuCu 200 GeV****corrected 2/10/05**

- J/ clearly seen in LVL2 filtered events:

**MUID North**

**MUID South**

**(~700 ********b****-1**** processed through LVL2 and reconstruction, **
**~1600 J/******** in South arm, ~1100 J/******** in North Arm)**

- Results obtained in semi-real time! (less than 2 days from data to go through LVL2, calibration, and production).

- J. Lajoie - RHIC Machine/Expt. Meeting

- 2/8/2005

## J/’e+e- in CuCu 200 GeV

- J/ also seen in central arm data:

**(~800 ********b****-1**** processed through LVL2 and reconstruction**,**~260 events in peak)**

- Results obtained in semi-real time! (less than 2 days from data to go through LVL2, calibration, and production).

- Level-1 threshold

- J/Y peak above like-sign background.

- J. Lajoie - RHIC Machine/Expt. Meeting

- 2/8/2005

## 200GeV CuCu Integrated Luminosity

**200GeV CuCu Integrated Luminosity**

**1.11 nb****-1 ****live BBCLL1 (********=2.91 b)**

**(941 ********b****-1 ****with MuID North/South)**

**1.78 nb****-1 ****live ZDCNS (********=2.6 b)**

**PHENIX Goal 2.9 nb****-1 ****live BBCLL1**

**3.1 B BBCLL1 events **_**sampled**_
**463 M events **_**recorded**_

**(As of 2/8/2005)**

**(48 days = March 7****th****)**

- J. Lajoie - RHIC Machine/Expt. Meeting

- 2/8/2005

## Added 2/10/05

**Added 2/10/05**

- J. Lajoie - RHIC Machine/Expt. Meeting

- 2/8/2005

## Added 2/11/05

**Added 2/11/05**

- J. Lajoie - RHIC Machine/Expt. Meeting

- 2/8/2005
# Presentation: 560854

## Comments on EMC slewing correction

- Comparing Arkadij to PPG016
- R. Seto –UCR
- PPG016 meeting
- Aug 7, 2003

## What I did

- I tried to understand what the differences between arkady and ppg016 corrections were
- Do I understand what the correction is??
- Let me show what I did
- My tentative conclusions
- Momentum dependence – important at low momentum (?)
- Some question of differences between ppg016 plots and arkady’s

## Comparison of MethodsArkadij                                   PPG016            

- Arkadij has not finalized his methid at least up to the last time he talked the HWG
- Looks at dependence on
- Run
- Sector
- Ecent
- Momentum
- Particle species
- Slewing function:
- T0=p0 +p1/x+p2/x2  (K-)
-  T0=p0 +p1(ln(x)+p2)2 (K+)
- where x=p, Ecent

- We hope for a fairly simplified thing for Kaons
- Look at dependence on
- Run (??? Maybe not)
- Sector
- Ecent
- Momentum ???
- K+ K-
- Slewing function:
- T0=p0 +p1/x+p2*x
- Where x=Ecent
- but find separate set of parameters for each p, and hope all are the same
- NOTE: typo on some documentation !

## Plans:

- PPG016
- Kaons only
- Find different sets of parameter for a variety of conditions  (Ecent)
- Run (hope its minor)
- Sector (major)
- Momentum (hope its minor)
- K+ or K- ??
- Note:
- Resolution of EMC tof ~400 ps
- Arkadij – run by run variation of one sector, one momentum, one Ecent, just pions ~ 500 ps

- Arkadij original?
-  pions only ???
- Remove Run/sector offset for some (p,Ecent)
- Remove Ecent dependence (slewing)
- Remove momentum dependence in T0 offset
- Fit m2 and form isPi, K, p
- New plan?
- Skip momentum correction and find centroid and width for West arm with and without Ecent>200 MeV cut

## Arkadij – run dependence

## Can we see momentum dependence?

- To first order by looking at only Slewing curve – no (both Arkadij/PPG016)

## For p<500 MeV – yes?  Can we continue to ignore it?

## Comparison STAR/PHENIX : TOF/EMCMT~ 1.2 for phi starts to matter

**Comparison STAR/PHENIX : TOF/EMC****MT~ 1.2 for phi starts to matter**

## Between MT of
 350 and 550
i.e. pt ~ 600 MeV

- Kaons (K-) TOF to EMC

- Between MT of
-  350 and 550
- i.e. pt ~ 600 MeV

## How big is the momentum dependence effect? 

- Mt~1.2
- Pt (phi) ~.6
- Pt(K)~.3
- ~200ns or 1⁄2 sigma (sigma~400ps)
- If we took +- 2 sigma
- -2 to 2  (.954)
- -1.5 to 2.5 (.927)
- So effect is about 3%
- Probably Ok to ignore this...

## Timing resolution ~ 400 ns

## Comparison K+

## Comparison K-

## Compare fit function

- Fit function don’t match ?
- Black – arkadij
- Pi+
- E2
- P=.6-.8
- Red – ppg016
- E2
- Positive

## Differences between Arkadij and PPG016

- Up to ~400 ps (I.e. 1sigma)
- +-2 sigma=.954
- -1 to 3 sigma = .84
- So now the effect is ~10%
- This we probably need to worry about
- SO
- I agree we ignore momentum effect
- Worry about run/sector dependence
- Charge dependence??
- Resolve why Arkadij and ppg016 don’t agree?
# Presentation: 489244

_***J.H. Schultz***_
_**M.I.T. Plasma Science and Fusion Center**_
*** ***
**NSO PAC 2 Meeting******
****
- January 17-18, 2001

- Design Point Trade Studies

- Progress in Design Point Studies

- 1. IPB98(y.2) Scaling
- 	- reduced 2.0 m Wedged FIRE from Q=10 to Q=5 at 10 T
- 	- parametric study explores bucked/wedged option for 		cost/mission improvements
- 2. Equalization of TF/CS "burn times"
- 	- optimization of TF/CS interface
- 3. Scan of A, Bt for "Fixed Mission"
- 	- Margin=2 and Margin=1
- 4. Detailed Cost vs. Ro Sensitivities

- Sizing Model

- tburn,TF = tburn,OH (TF/OH interface optimum for fixed Ro
- 	Subtract 3 s from TF flattop for heating
- e.g. 24.5 s flattop = 24.5 s I flattop = 3 s heat + 21.5 s burn
- 	No scaling of theat with plasma parameters
**(2) Minimum Ro for "Mission Margin"**
- Mission: Long-pulse -dominated plasmas
- Margin=2: Q>=10; tflattop/max(E, p*, J) >= 2
- Margin=1: Q>=5; tflattop/max(E, p*, J) >= 1

- Double Optimization Method

## Instead of fixing Ro and varying A

- Vary Ro and A, while holding Margin=1,2
- Margin=min(P/Pheat, tflattop/J)
- 3 Variations:
- 1) Minimum Ro(fixed A,B)with M=min(P/Pheat, tflattop/J)
- 2) Minimum Ro(fixed A, Bvariable @ low A); M=Const
- 3) Minimum Ro(fixed A,B, f(q) @ high B); M=Const

## Alpha margin=Time margin=2 at optimum A=2.0/0.525

- Rapid rise in time margin and heating margin off optimum A

## Reduced Mission: M=1, Q=5,tburn/J=1

- R o,min = 1.59 m at Bt=11.5 T & A=(2.0/0.525)=3.8095
- Bt=11.5 T for A=3.8
- Bt=10.5 T for A=3.6
- R(low A) nonlinear, but not pathological

- Ro (m) vs. Bt: M=2, Q=10, t/tauJ=2

- Ro (m) grows pathologically at high Bt and qlim=3.1
- Well-behaved if M=2,Q=10,t/J=2
- (qlim > 3.1 at Bt>Bt,opt)

- Romin=1.86 m, A=3.8
- Romin (A=3.6) = 1.925 m

- Ro (m) vs. A; M=2, Q=10,t/tauJ=2;
- Bt=10.5, 11.5 T, qlim=3.177

- Romin = 1.86 m@ Bt=11.5, A=3.8
- Ro (m) pathological at low A
- Cured by lowering Bt; Q=10, M=2
- (no effect on Romin)

## M2:Minimum Cost =$1.06 B @ Ro= 1.86 m, A=3.8, Bt=11.5 T

- 	- M2 < $1 B, if phase auxiliary power
- M1:Minimum Cost = $0.92 B @ Ro=1.59 m, A=3.8, Bt=11.5 T

- Cost (M$) vs. Ro (m); Subsystem Sensitivity

-  Vary Ro; Bt=11.5 T, A=3.8,
- qL=3.1, not fixed mission
- $/Ro Sensitivity = 1.01

- $/Ro: Paux, I&C = 0
- Magnets=1.64
- Basic Machine=1.25
- Buildings=1.14

- Exciting

- Conclusions

- Ro can be reduced to 1.86 m and retain M=2 mission
- Mission reduction x 2 allows reduction of Ro to 1.59 m (1st order!)
- Margin=2 mission requires lowering B @ A<3.5 or q @ B>13 T
- d$/dR = 1: Machine sensitivity ~ 1.25 + nearly fixed costs
**Recommendation: Reduce R****o**** to 1.87 m, Day 1 RF = 10 MW**
**Achieve all cost/mission objectives: Q=10, ********flat****/********J****=2, Cost<$1 B**
**Historic first: A noncatastrophic reduction in NSO R****o**
# Presentation: 864546

-    The Myth of Indefinite Shelf Life

- Event Related
- Versus
- Time Related
- Shelf Life for Medical/Surgical Devices

## Bobby L. Osburn

**Chief Materiel Management Assistance Staff &**
**SPD Program Official**
**Department of Veterans Affairs**
**VA Headquarters **
**Washington, DC**

## Shelf Life

## SHELF  LIFEWHAT DOES IT MEAN?

-  Does it have to to with sterility?
-  (it can,   depending on the packaging of hospital processed items)
- Does Un-sterile items have a shelf
-    life?

- Expires 10/2008

- Content guaranteed sterile if package is
-  not open or damaged

## Shelf-Life  “&”

- EVENTS:
- 	Nosocomial Infections (Hospital Acquired)
-     40,000 Americans die each year
- 			(Sept. 11, 2001  3,000 die)
- TIME:
-     up to 200,000 die each year from incidents

## Event-Relateddoes not mean Indefinite

- How do you document  what events did or did not take place?

## What does it mean?
		Unclear;  vague
		Uncertain; undecided;
		Lacking precise limits

- 		Unclear;  vague
- 		Uncertain; undecided;
- 		Lacking precise limits

## Event:

- Something that takes place. Occurrence
- A significant occurrence or happening

- Time

**A number, as of years, days, or minutes, representing such an interval**

## EVERYTHING IS AFFECTED BY TIME

- It's   called   aging

## EVERYTHING IS AFFECTED BY TIME

**While time has its affects, there are many events that can**
** ****speed up the process!  **

## Time-RelatedEffects on Medical/Surgical Devices

- Rubbers; Plastics
- Metal, Sharps
- Packaging

## Hospital Processed Devices

## “Events”

- Some events we can control and some we can’t,  If we can and don’t results can be __ ___ __ !

## Events that affectMedical/Surgical Devices

-  Receiving
- Storage
- Transports
- Temperature
- Humidity
- Handling
- Other Environmental Issues

## EVENTS :

## Inventory Managementand

-  Event-Related
- Time-Related

- "Shelf  Life"

## 		SHELF LIFE &JOINT COMMISSION ON ACCREDITATION OF HEALTHCARE ORGANIZATIOPNS (JCAHO)

- IC.4  The hospital takes action to control outbreaks of nosocomial infections in patients, employees, and visitors

## Shelf Life & JCAHO

- Processes designed to provide for the continued sterility of hospital-sterilized and commercially prepared items through appropriate packaging, storage, and other methods to provide for package integrity.
- The designation of time-related or event-related shelf life for hospital-sterilized items.
- The designation of time-related or event-related shelf life for commercially prepared items that do not have a specified expirations date and are labeled by the manufacturer as being sterile.
- A process that provides for recall and disposal or reprocessing of outdated sterile supplies, if a time-related designation is used.

## Event Related

**DOES NOT MEAN !**
# Presentation: 757775

## SST from MODIS AQUA and TERRA 

- Kay Kilpatrick, Ed Kearns, Bob Evans, and Peter Minnett
- Rosenstiel School of Marine and Atmospheric Science
- University of Miami
- MODIS Science Team Meeting
- Baltimore, MD. July 2004

## Sea Surface temperature Cal/ValMODIS AQUA and TERRAMODAPS/DAAC archived Products

## TERRA global cal/val stats

## AQUA global cal/cal stats

## Aggregate stats

- Aggregate globally distributed matchups for each sensor ,quantify and validate the existing code and production of Seasurface temperature at MODAPS
- The instruments continue to  perform very well relative to in-situ measurements. Time series show no obvious trends and residuals are stable in time and latitude. (see poster)
- Statistics are comparable to those of the AVHRR Pathfinder SST. Comparisons of collocated retrievals with AMSR and ATSR, TMI are also very good.
- Analysis with respect to mirror side and sat zenith angle suggest further improvements are possible to improve accuracy and reduce uncertainty.

## TERRA 11-12um SST cal/valMirror side and Sat zenith angle

## TERRA SST 4.5 coefficients

- Terra residuals show a “classic V” shape as a function of Zenith angle.  Suggesting a small error in the in the atmospheric/4th term of the algorithm. Apex of the “V” is a nadir at the expected -0.05-  -0.1 oC skin-bulk offset.
- Sensor measures skin temperature and is expected to generally be colder than the buoys.
- Two mirror sides appear to behave in a similar manner.

## AQUA MODIS Buoy & M-AERI matchups

## AQUA MODIS Buoy & M-AERI matchups – highest quality

## AQUA 11-12um SST cal/valmirror side and Sat zenith angle

## AQUA SST 4.5 coefficients

- AQUA’s two mirror sides do not behave the same.
- Classic “V” pattern of residuals  with satellite zenith angle is not present.
- Results suggest that small RVS remains  as there is a suggestion of a slope across the scan. (AQUA MCST RVS based on pre-launch data, TERRA based on closed Door on orbit data)
- Nadir values are near Zero rather than the expected -0.05- -0.1.

## AQUA coefficients 4.5

- Examination of AQUA low water vapor regime d31-32 <0.7 suggest a more flat line with a hint of a “V” with respect to sat zenith angle with on offset at -0.1. At Nadir for both mirror sides.
- The fact that trends are only present in high water vapor regimes suggest that the RVS problem maybe restricted to band 32 only, as it is only in these conditions that band 32 comes into play thru the band 31-32 difference term.
- In low WV band 31 dominated.
- More matchups in high latitude cold dry atmospheres are needed to confirm results.

## Plans for SST collection 5

- Revised coeffficeints sst and sst4
- Revised l1b emmissive LUT  for oceans thermal and mid and ir bands?
- Better RVS corrections
- L1b schedule 9/10/04 TERRA, AQUA 12/3/04
- Schedule TERRA 2/1/05, AQUA 5/1/05
- Decision trees better cloud flagging
- use of sst4 as first guess at night) more for the ocean talk.
# Presentation: 516432

## To verify your own supervisor in WebTCAS, click on “View Master Record”.

## If your supervisor is incorrect or missing, contact your area office or state office timekeeper, who will contact HR

## To select a backup supervisor, click on “Update Profile”

## Click on “Search”

## Click on the circle next to the employee’s name who will be your backup supervisor, repeat the process for a second backup

## Make sure you “Save Profile”

## Once a supervisor has assigned you as a backup supervisor, you can access another supervisor’s employee timesheets by clicking on the drop-down box as indicated...

## Highlight the supervisor and click, once that supervisor’s name shows in this field, you will be able to access their employees’ timesheets.
# Presentation: 700607

## Initial analysis of the GFDL Earth System Model

- Anand Gnanadesikan

## First order of business

- We need to appreciate John, Lena, Sergey, Rick, and Fei for their work putting this model together. Thank you!

## First run

- Atmospheric CO2 overridden in radiation code with value of 276 ppmv- also overridden for fluxes.
- Ocean run from Levitus 20 years, then coupled.
- Land initialization is modern

- Proof of concept run, also useful for scoping out where we might end up with problems.

## Good news: Global climate does not show large drifts

## TOA radiative diagnostic

## Some interesting changes in wind stress

- Changes largely found in the Pacific sector.

## Ocean biogeochemistry: Primary productivity

- Observed primary productivity
- ~ 60 GtC/yr
- Modelled primary productivity
- ~56 GtC/yr

## Primary and export production

## Air-sea carbon flux

- Black line: ESM2.1
- Net is 1.15 Gt/yr to atmosphere.
- Red and blue lines:
- Princeton OCMIP2 runs
- Big problem in Southern Ocean

## Southern Ocean “leakage” and the “red vs. blue” circulation (Toggweiler ,Russell,and Carson, Marinov et al.)

## Surface nutrients

## Nitrate-based production

## One possibility, insufficient iron?

## Land vegetation

## ..but NPP shows we have a problem

- Amazon has died

## Possible reasons for this problem

- Too little rain (atmospheric problem).
- Too strong a feedback between drying and transpiration (land model problem).
- Too strong a feedback between surface drying and upper-level precipitation.

## Seasonal precipitation shows that we have a dry season from the beginning of the run.

- Black: ESM2.1A
- Red: CM2.1 1860 control
- Green: CM2.1 1990 Control

## Evidence of transpiration feedback

- Black: ESM2.1A
- Red: CM2.1 1860 control
- Green: CM2.1 1990 Control

## Issues raised here

- Initialization, what should we be doing?
- Do we need to tweak the iron cycle in the ocean?
- What should we do in the Amazon?
# Presentation: 004969

## Ion Exchange at Metal–Ceramic InterfacesF. Ernst,1 R. Raj21Case Western Reserve University, 2University of Colorado at BoulderDMR-0208008

- _Objectives:_
- • To study diffusion reactions at planar aluminum-spinel (Al–MgAl2O4) interfaces.
- • To investigate the effect of an external electric field on diffusion reactions at such interfaces.

**Ion Exchange at Metal–Ceramic Interfaces****F. Ernst,****1**** R. Raj****2**1Case Western Reserve University, 2University of Colorado at Boulder**DMR-0208008**

- _Result:_
- Tempering aluminum–spinel interfaces in applied *electric fields*, we found credible evidence that diffusion reactions of magnesium, aluminum, and oxygen ions can be controlled by the strength and polarity of applied electric fields.  Positive ions were more mobile than negative ions in a spinel under the influence of applied electric fields. Differences in mobility and valency of constituent ions suggest a correlation between interdiffusion and electrical fields, which is conceptually consistent with the electrostatic model of mechanical adhesion.

**MgAl****2****O****4**

**Al film**

**Al**

**O**

**Mg**

**Mg-deficient reaction layer**

**Right: High-resolution TEM image revealing the interface structure of an as-grown ****Al–MgAl****2****O****4****.**

**Right: Composition profiles show the different response (diffusion) of ions across the interface when annealing in an external electric field.**

**Al film**

**MgAl****2****O****4**

**2 nm**

**Al****3+**

**Mg****2+**

## Ion Exchange at Metal–Ceramic InterfacesF. Ernst,1 R. Raj21Case Western Reserve University, 2University of Colorado at BoulderDMR-0208008

- Education and Outreach
- On January 14 and 21, 2005, the team at Case invited students of the Ruffing Montessori middle school in Cleveland Heights for two lectures on "Materials and Microscopy" and a hands-on demonstration of scanning electron microscopy and transmission electron microscopy. (_[http://www.ruffingeast.org/webpages/middle_school.htm](http://www.ruffingeast.org/webpages/middle_school.htm)__ _)
**Jeremy Mark**, an undergraduate student performed his senior project in relation to this project.
**Gurpreet Singh**, graduate student at UCB, was trained in UHV techniques, thin-film preparation, and mechanical testing of thin films.
**Yeonseo Yu**, graduate student at Case completed his Ph.D. degree in August 2005.  His Ph.D. thesis is based on the work on this project.

- Broader Impacts
- The latest results of this project are going to be presented at the 2006 TMS Annual Meeting & Exhibition.
- A journal article about the effects of annealing under applied electric fields is in preparation.
# Presentation: 061412

## Astrobiology  Roadmap

## Astrobiology   

- Understanding the origins, evolution
- and distribution of life in the universe

## Seeking Additional Examples of Life...

- Determinism
- Do “proper” environments usually lead to life?
- How might evolution elsewhere resemble our own?
- Diversity
- Is our biosphere a subset of the full diversity of life?
- What are the ultimate environmental limits of life?
- Definition
- Life is the harnessing of energy to create & maintain a high density of information in the form of complex molecules & structures

## Astrobiology Questions

- Does life exist elsewhere in the universe?
- What is the future of life on Earth and beyond?

## Slide 5

## Astrobiology Goals

- Determine the general principles governing the organization of matter into living systems
- Explore how life evolves on the molecular, organism, and ecosystem levels
- Determine how the terrestrial biosphere has co-evolved with the Earth
- Establish limits for life in environments that provide analogs for conditions on other worlds

## Astrobiology Goals (continued)

- Determine how to recognize the signature of life on other worlds
- Determine whether there is (or once was) life elsewhere in our solar system, particularly on Mars and Europa
- Determine how ecosystems respond to environmental change on time-scales relevant to human life on Earth
- Understand the response of terrestrial life to conditions in space or on other planets

- Astrobiology Goals (continued)

## Slide 8

## Slide 9

## Slide 10

## Slide 11

## Slide 12

## Slide 13

## Biomarkers/Biosignatures

- An object, substance and/or pattern whose origin specifically requires a biological agent
- Astrobiological exploration is founded upon the premise that biomarkers encountered beyond Earth will be recognizable
- Categories:  Ecosystem structures & textures, cellular & extracellular morphologies, organic compounds, minerals, stable isotope patterns, spectra from distant inhabited planets

## Slide 15

## Slide 16

## Slide 17

## Slide 18

## Astrobiology Operating Principles

- Astrobiology is fundamentally disciplinary.
- Planetary stewardship via a planetary protection program is intrinsic to missions
- A broad societal interest mandates public participation in key decisions, e.g., regarding extraterrestrial life and novel life forms
- Intrinsically inspiring exploration program merits vigorous education and public outreach.

## L. Prufert Bebout

## End
# Presentation: 688025

## Suspicious Activity Report Filing Trend for the State of Massachusetts                                                                                      For the Period April 1, 1996 through December 31, 2007

***Total SARs: 64,195***

**Suspicious Activity Report Filing Trend for the State of Massachusetts                                                                                      For the Period April 1, 1996 through December 31, 2007**

## Characterizations of Suspicious Activity for the State of Massachusetts

- Note:  The pie chart represents the top nine characterizations plus additional characterizations in total.
-            An individual SAR may cite more than one characterization.  Hence, the number of characterizations detailed here significantly exceeds the total number of SARs.

**Characterizations of Suspicious Activity for the State of Massachusetts**
**For the Period April 1, 1996 through December 31, 2007**

## Massachusetts Mortgage Loan Fraud SAR Filing Trend For the Period April 1, 1996 through December 31, 2007

***Total SARs: 1,985***

- Note:  Suspicious Activity Report statistical data is continuously updated as additional reports are filed and processed.  For this reason, there may be minor discrepancies between the statistical figures contained in this report and those in previous FinCEN reports.  Annual numbers for this exhibit are calculated by ***Subject Address*** and not filer address; therefore, the annual totals appearing in the above graph do not match those in Section 1, Exhibit 8 (Characterization of Suspicious Activity by State & Territory by Year).

## Suspicious Activity Report Geographic Pattern for the State of Massachusetts

**For the Period January 1, 2006 through December 31, 2006**

**Note: Statistics based on Filer Branch Address**

## Suspicious Activity Report Geographic Pattern for the State of Massachusetts

**For the Period January 1, 2007 through December 31, 2007**

**Note: Statistics based on Filer Branch Address**

- Hyannis
# Presentation: 498303

## Navajo Nation Climate Data Recovery

**Arizona State Climate Office**
**Nancy J. Selover, Ph.D.**
**State Climatologist **
**Arizona State University**
**Tempe, AZ  85287-1508**
**480-965-0580**
- _[selover@asu.edu](mailto:selover@asu.edu)_
- _[http://](http://geography.asu.edu/azclimate)__[geography.asu.edu/azclimate](http://geography.asu.edu/azclimate)_** **

## 23 Automated Weather Stations 

- 23 Automated Weather Stations
- Hourly and Daily data
- No remote communications
- Downloaded periodically
- Line printer printouts
- Computer systems replaced and most digital data were not archived.  Only 4 stations have digital daily data (6, 9, 10, 11 year records).
- Various record lengths from 2 to 13 years
- Records from 1986 to 1999

## Slide 3

## Variables:

_**Variables:**_
_**Hourly**__**	**__**	**__**	**__**	**__**Daily**_
- Air Temperature			Maximum Air Temperature
- Relative Humidity			Minimum Air Temperature
- Precipitation			Average Air Temperature
- Total Solar Radiation		Maximum Relative Humidity
- Average Wind Speed		Minimum Relative Humidity
- Maximum Wind Speed		Average Relative Humidity
- Vector average Wind Direction	Precipitation
- Soil Temperature 4” depth 		Total Solar Radiation
- Soil Temperature 9” depth 		Soil Moisture 4” depth
- Soil Temperature 15” depth	Soil Moisture 9” depth
- 				Soil Moisture 15” depth
- 				Maximum Soil Temperature 4” depth
- 				Minimum Soil Temperature 4” depth
- 				Average Soil Temperature 4” depth
- 				Maximum Soil Temperature 9” depth
- 				Minimum Soil Temperature 9” depth
- 				Average Soil Temperature 9” depth
- 				Maximum Soil Temperature 15” depth
- 				Minimum Soil Temperature 15” depth
- 				Average Soil Temperature 15” depth

## Slide 5

## Slide 6

## First of 2 daily data pages

**First of 2 daily data pages**

## Second of 2 daily data pages

**Second of 2 daily data pages**

## Hourly data page

**Hourly data page**
# Presentation: 463181

## The Food and Drug Administration:An Overview

***Patricia R. Robuck, Ph.D., M.P.H.***
*Director, Clinical Trials Program*
*Division of Digestive Diseases and Nutrition*
*National Institute of Diabetes and Digestive and Kidney Diseases*
*National Institutes of Health*

## The FDA Mission

- To Protect the public health, as directed by the Food, Drug and Cosmetic Act.
- To Administer the statutory framework for providing new and better products.

## Drug Development and Investigational New Drug Applications (IND)

- What is an IND ?
- Purpose of an IND
- Who needs an IND ?
- What are the IND exemptions ?
- Where do I get more information?

## What is an IND?  

**NOT an application for Marketing Approval**
**Request for exemption from federal statute that prohibits an unapproved  drug from being shipped in interstate commerce.**

## Purpose of an IND?  

**Provide data showing that it is reasonable to begins tests of a new drug in humans.**
**based on preclinical data**
**Allow for shipment of drug across state lines**

## Who needs and IND ? 

- Clinical study of an unapproved product
- Clinical _**study**_ –
- investigational use of approved product (experiment administering drug to human)
- clinical trial
- UNLESS receive an Exemption

## What are the IND exemptions ?

**Must meet all of the following:**
- Not intended to support a change in indication
- No increase in risk (route of administration, dose, subject population)
- Not intended to support changes in advertising

## What are the IND exemptions ?(con’t)

- In compliance with IRB and Informed Consent
- In compliance with requirements re: promotion and sale of drugs (21 CFR 312.7)
- Not seeking exception from informed consent requirements for emergency research

## For more information .....

## http://www.fda.gov/cder/regulatory/applications/ind_page_1.htm

## http://www.fda.gov/cder/about/smallbiz/faq.htm#Investigational%20New%20Drug%20Process

## CLINICAL STUDIES ROCK!
# Presentation: 129801

## Status of Incorporating Ice Into NWS Hydraulic Models

- Janice Sylvestre
- NOAA NWS Office of Hydrologic Development
- In Collaboration with
- Dr. Steven F. Daly
- ERDC/CRRL

- 2004 Cold Regions Workshop
- November 15-18, 2004
- NWS Training Center
- Kansas City, MO

## Objective

- Add river ice modeling capability to NWS FLDWAV model based on ERDC/CRREL methodology developed by Dr. Steven Daly.

- After Daly, 2004

## Hydraulic Component: Modifications to account for the presence of  ice

- Geometric terms in continuity and momentum equations:
- Area, Hydraulic Radius, roughness, conveyance
- Dynamic modification of geometric “look-up” tables
- Representation of the dynamic ice cover extent
- Time varying ice roughness

- 

- 

- 

- 

- After Daly, 2004

## FLDWAV Modeling Assumptions

- River ice is stationary
- Ice information from observations

## FLDWAV Input Parameters

- For each ice block along the river:
- Upstream & downstream location of ice block
- Time period of ice block existence
- Ice block formation period
- Ice thickness
- Specific weight of ice
- Roughness coefficient for ice
- A sensitivity analysis will be done on the parameters to determine how critical they are – which ones can be given default values?

## FLDWAV Test Area

- River ice effects were observed when calibrating the Susquehanna River system
- FLDWAV ice effect enhancement is being tested using this data

- Verification Flood Period

- Ice jam confirmed in Wyoming County on Jan 25th.  No other info available.

## Continued Research

- Test FLDWAV capability thoroughly in areas with observed data
- Add ice movement option
- Determine feasibility of modeling ice cover formation operationally
# Presentation: 134721

## FAR DETECTOR:

- 96.5% livetime last week *(wall clock)*
- Down time from 9:00-15:00 Thursday 27 March.  Minnesota Power repaired a lightning arrestor on the 4,800V power feed, detector came back up with only one blown fuse (VME card)
- Accelerator took this opportunity to also fix stuff
- Everything fixed and running before the accelerator complex came back up from its maintenance
- _NEAR DETECTOR_:
- Close to 100% live *(beam weighted)*
- Sump-side filter for LCW system clogged on Sunday.  Coil down while filter cleaned out, but happened during MI vacuum problem downtime, so no beam lost

## Protons/pulse:
~23x1012: 2+9 6-turns mixed
~26x1012: 2+9 7-turns mixed
~32x1012: NuMI only (during pbar recycler transfers)

- Protons/pulse:
- ~23x1012: 2+9 6-turns mixed
- ~26x1012: 2+9 7-turns mixed
- ~32x1012: NuMI only (during pbar recycler transfers)

- <2.51 E13 ppp>
- Best week 2.59 E13

##  ~190kW with 6 turns, ~230kW with 7 turns, ~270kW in NuMI only(no MTEST this week)

-  ~190kW with 6 turns, ~230kW with 7 turns, ~270kW in NuMI only(no MTEST this week)

- No NuMI specific downtime for previous two weeks now, however...*(* see next slide!)*

- <206 kW>
- Best week 214 kW

- 5.25E18
- Best week 6E18 pot

-  MI vacuum

-  FD Power, MI, Booster
-      Linac,
-        Linac

-  Linac

**Notes:**
Tevatron magnet failure, pbar maintenance

## QD111 has had a weeper leak for three months
In awkward location, no corresponding MI downtime opportunity, so not preemptively replaced
After cooling off during yesterday’s MI vacuum problems, the quad wouldn’t come back
Not the PS, but we won’t know till tomorrow morning if it’s an external, repairable short or a nasty internal one

- In awkward location, no corresponding MI downtime opportunity, so not preemptively replaced
- After cooling off during yesterday’s MI vacuum problems, the quad wouldn’t come back
- Not the PS, but we won’t know till tomorrow morning if it’s an external, repairable short or a nasty internal one

## At the end of the NuMI stub
Essential to focus beam to NuMI carrier line, so can’t run without it
If replacement is needed:
Repairs take ~2.5 days, but can’t run MI or RR during them
Lots of challenging rigging
Will start repairs tomorrow after the Tevatron gets a store

- Essential to focus beam to NuMI carrier line, so can’t run without it
- If replacement is needed:
- Repairs take ~2.5 days, but can’t run MI or RR during them
- Lots of challenging rigging
- Will start repairs tomorrow after the Tevatron gets a store

## A Gordon’s Eye View of the scene:

## Protons per day (E17)

-  end of 2007 shutdown

***Protons per day (E17)***

**Notes:**
Fix label on LHS

##  end of 2007 shutdown

-  end of 2007 shutdown
# Presentation: 180036

## Section 7

**Current Status**

## Current Status

***All NMP mission objectives were accomplished within 13 months of launch as planned***
***EO-1 now beginning 19th month of operation and is now in an Extended Mission based on a partnership with the U.S. Geological Survey (USGS)***
***EO-1 is fully functional and has spacecraft consumables to last at least another two years***
***EO-1 Science Validation has revealed numerous scientific applications for the Advanced Land Imager and the Hyperion***
***Continuous Improvements to Operations have steadily reduced the cost of imagery to facilitate widespread availability of EO-1 imagery***

## USGS/NASA EO-1 Extended Mission

***This satellite image, centered on the Big Bend National Park in southwestern Texas, was acquired on January 25, 2002 by the Advanced Land Imager (ALI) instrument onboard NASA’s Earth Observing-1 (EO-1).***
***This scene is the first EO-1 satellite image directly downlinked to the USGS EROS Data Center and successfully processed through the newly installed Data Processing System and ALI Level 1 system.***
***The NASA New Millennium Program’s EO-1, launched on November 21, 2000, was designed as a one-year mission to flight-validate a variety of new technologies aimed at lowering the cost and increasing the performance of future Earth science missions. Part of the EO-1 technology validation effort is applicable to the future Landsat Data Continuity Mission (LDCM).***
***The superior performance of the satellite and instruments, and exceptional interest and value in the unique satellite imagery has led NASA and the USGS to enter a joint partnership for an extended operational mission.***

***EO-1’s imaging technologies include Hyperion, the world’s only hyperspectral satellite sensor with 220-bands at 30-meter spatial resolution; and the ALI, a lightweight, high performance, multi-spectral sensor (LDCM prototype) at 30-meter (multi-spectral bands) spatial resolution and a 10-meter panchromatic band. NASA and USGS scientists believe that the datasets will prove valuable to global land cover studies, ecosystem monitoring, mineral and petroleum prospecting, and agricultural crop assessment, among other potential applications.***
***Image data products are now distributed by USGS EROS Data Center in Sioux Falls, South Dakota to a broad customer constituency including scientific and academic users, U.S. Government agencies, and the commercial remote sensing / GIS industry. Additional information can be found at:  http://eo1.usgs.gov/***

*U.S. Department of the Interior / U.S. Geological Survey*

## Monthly Cost of a DCE

- EDC X-Band Ground Station Operational

## Workload After Launch

***Chart shows procedures run by FOT console folks in blue***
***Significant reduction resulted from automation***

## Science Data Collects

***Chart shows, per day, number of science data collects in blue.***
***Trendline shows increase in science data collects.***

**DCEs (Scenes & Calibrations) Monthly Average**
# Presentation: 693794

##        OCAST & Technology Commercialization

***Dan Luton***
***Oklahoma Center for the Advancement of Science and Technology (OCAST)***
**6****th**** Annual NIH SBIR/STTR National Conference****June 23 & 24, 2004**

## OCAST’s Mission

* ****TO FOSTER INNOVATION IN EXISTING AND DEVELOPING BUSINESSES***
- By *supporting* basic and applied research
- By *facilitating* technology transfer between research     laboratories and firms and farms
- By *providing* seed-capital for new innovative firms and their products, and
- By *fostering* enhanced competitiveness in the national and international markets by small and medium-sized manufacturing firms in Oklahoma by stimulating productivity and modernization of such firms.

## Technology Pipeline Programs Concept to Commercialization

## Oklahoma Technology Commercialization Center 

- 	The Tech Center is operated for OCAST through a contract with i2E, Inc. a private not-for-profit corporation
- 	The Tech Center assists start‐up and existing advanced technology companies commercialize new technology by providing services such as: feasibility studies, marketing plans, business plans and access to early stage risk capital.

## OCAST Technology Business Finance Program (TBFP)

- 	i2E, Inc. also operates the OCAST Technology Business Finance Program
- 	The TBFP program provides limited ($100K - $150K) pre-seed financing for qualified start‐up advanced technology firms.

## Technology Commercialization 

- Step 1. Determine where the company is in the commercialization process
- Is there a “thing” to show investors?
- Is there an established revenue stream?
- Who owns the intellectual property?
- Is there interest in the technology?
- Are there manufacturing capabilities?

## Technology Commercialization 

- Step 2. Conduct basic needs assessment
- What does the company need to survive what are the goals?
- Revenue
- Management/business support
- Additional R&D capital
- Assistance with transitioning technology into a government program

## Technology Commercialization

- Step 3. Develop a set of “next step” action items based on the needs assessment
- Locate a partner
- Locate and hire a business manager
- Restructure/reorganize
- Etc.

## Technology Commercialization

- Step 4. Introduce company to a technology resources group – business mentoring
- 	Group of professionals from a variety of disciplines who can provide technical, marketing and business development services needed by high tech start-up companies

## Technology Commercialization

- Stage I: Assessment
- Business Model Review
- QuickView Analysis
- Roadshow Introduction

## Technology Commercialization

- Stage II: Validation
- Final Business Model Review
- Valuation Workshop
- Roadshow Workshop
- Oklahoma Capital Network Introduction

## OCAST

***For more about OCAST programs, ***
***website: ******www.ocast.state.ok.us ***
*** ******phone:****** 405-524-1357 ext 232***
***toll free:****** 866-265-2215 ext 232***
***e-mail:****** dluton@ocast.state.ok.us***
# Presentation: 766839

## Houston’sAlternative Certification Program

**Susan Sclafani**
- Chief of Staff for Educational Services
- Houston Independent School District

**A Partial Solution to Teacher Shortages**

**Archived Information**

**Notes:**
Proud to present the Houston Independent School District.  
Period of great accomplishment for children.  
No greater mission, no greater challenge, no greater reward.

## 73.1%

**HISD serves a richly diverse student population**

**Free/Reduced Lunch: ****(family of 4 maximum income: $1,739/month) **
**73.1%**

**Student Enrollment: **
**210,200**

**Ethnicity:**
**Hispanic                  53.1%**
**African American   33.8%**
**White/Asian            10.3%**

**       ****Special ****       Programs:**
**Bilingual Education  15.8%**
**Special Education     10.5%**
**Gifted/Talented            9.1%**

## HISD Ethnicity Trend

**Thousands**

**HISD Ethnicity Trend**

**(1999 Data:  Hispanic 53.1%,  Black 33.8%,  White 10.3%)**

**White**

**Black**

**Hispanic**

## Texas Teacher Shortages

**TEXAS**
**63,300 Vacancies in 1998-99**
**21,900 Teachers Certified in 1997-98**
**12,200 University Graduates**
**2,700 ACP Graduates**
**7,000 Out-of-State Transfer of Certification**
**Houston**
**1,400 Vacancies in 1999-2000**
**247 ACP Interns in Classrooms**

## Houston’s ACP Program

**First ACP in Texas in 1986**
**Over 4,000 Teachers Certified**
**Critical Shortage Areas****	**
**Mathematics and Science**
**Bilingual and ESL Education**
**Special Education**
**Bilingual Diagnosticians**
**Requirements**
**Bachelor’s Degree with 2.5 GPA**
**24 Semester Hours in Area of Certification**

## Critical Success Factors

**Rigorous Selection Process**
**Transcript Evaluation**
**Reference Checks**
**Gallup Urban Teacher Perceiver**
**High Quality Coursework**
**University Courses**
**Summer Preparation Seminars and Weekly Seminars**
**Intern Support in Classroom**
**Mentor Teacher**
**Principal Observations and Support**
**ACP Specialist****	**

## Critical Success Factors

**Opportunities for Growth**
**Release Time for Observations of Master Teachers**
**Substitute Days to Visit Other Schools**
**Debriefing Sessions Every Week for First Semester**
**Practice Sessions for State Certification Examination**
**Participation in District Professional Development **
**Evidence of Success**
**Mentor Teacher Observations**
**Principal Assessments**
**ACP Specialist’s Assessments**
**Portfolio of Lessons and Student Work****	**

## Retention Rates

**One-Year Retention Rates**
**Texas ****	****	****70%**
**Houston****	****86%**
**TFA****	****	****94%**
**Five-Year Retention Rates**
**60%****	****ACP**
**50%****	****Regularly Certified**
**30%****	****Teach for America**

## Retention RatesTeach for America

**Houston  1993-2000**
**55%  Teaching**
**16% Graduate School**
**9% Education Related**
**14% Working for Non-Profits**
**11% Education Related**
**Nationally**
**60% in Education**
# Presentation: 827951

## NIDDK Hepatotoxicity Network

- Jose Serrano M.D, Ph.D.
- Division of Digestive Diseases and Nutrition,
- National Institute of Diabetes and Digestive and Kidney Diseases

## Adverse Drug Reaction (ADR) is a significant clinical problem:

**	****6.7% Inpatients have significant ADRs. **
**	****0.3% Fatal (106,000 deaths)**
**	****5****th**** commonest cause of death in hospital**
***JAMA. *****1998;279:1200-1205**

- Hepatotoxicity  is the most common single ADR causing drug withdrawal and refusal for FDA approval

## Scientific opportunity

- The recognition of genetic variability as a determinant of the ADRs
- The development of high throughput gene profiling  and expression tools (genome-wide SNPs screening, expression arrays, proteomics)
-  Advances in bioinformatics and computing,

**Scientific opportunity**

## Pharmacogenetics: The study of variability in drug responses due to  hereditary factors in different populations

**Pharmacogenomics:** The determination and analysis of the genome and its expression (RNA, proteins) related to the  drug response

## Hepatotoxicity: NIDDK initiatives

- New directions in drug-Induced Injury: Mechanism and test Systems. **October 2000:**
-  R01, R21

## Hepatotoxicity: NIDDK initiatives

- 1 R01 DK 62322 (Kin-Wei Chang) Incidence of drug induced liver injury
- RFA DK02-033 HEPATOTOXICITY CLINICAL RESEARCH NETWORK

## HEPATOTOXICITY CLINICAL RESEARCH NETWORK .Purpose

**To collect biological specimen from bona fide  drug induced liver toxicity.**

## The Hepatotoxicity  Network. Goals

** ****To elucidate the genetics  and the mechanisms of hepatoxicity****.**** **** **

**To provide the foundation for :**
** ****the  development of   molecular screening tools to prevent drug-induced liver toxicities and**
** “****genetically” correct  therapies**

## “genetically” correct  therapies

**SNP profile**

**Controls**

**ADR**

**Predictive of   NO ADR**

**Predictive of    ADR**

**“****genetically” correct  therapies**

## Slide 10

## Pharmacogenomics of  Drug-induced Liver injury

**Clinical Events****:**
- 	Defined Hepatotoxicity, Patient identification/	capture, causality assessment

- Clinical Tissue/sample:
- 	Serum proteomics, metabonomics
- 	WBC genomics, expression profile
- 	Liver genomics, expression profile

## Profiling Analysis: 

- 	Candidate genes polymorphisms, mutations
- 	SNPs , limited or genome-wide
- 	Expression pattern: static vs dynamic

**Data Coordinating and  Tissue/ Sample Repository**

## Slide 13

## The Hepatotoxicity  Network. Time Course

- Clinical and Data Centers  Selected: Steering Committee

**Year 2-3**:
- ADR and samples collection

**The future** .......
- RFP  for Profiling.
- PA, RFA for  hypothesis driven studies

**The Hepatotoxicity  Network. Time Course**

- The cost for the profiling center-  ???
- 	number events (controls, cases)
- 	type (expression, proteomics, SNPs)
- 	technique (chips, sequencing,HPLC,OLA)

**The Hepatotoxicity  Network. Budget**

## What should be the relationship of the  Hepatotoxicity Network with..... 

- The FDA?

- Industry?