# Presentation: 531320

## Implementing the CTSA vision: accomplishments and challenges 

- David S. Guzick, MD PhD
- P.I.: University of Rochester CTSA
- Dean, UR School of Medicine & Dentistry

## Pre-CTSA

- Building blocks for clinical & translational science
- Senior Assoc Dean for Clinical Research
- Expand Biostatistics and Bioinformatics
- Create cross-departmental programs and identify faculty leaders
- Research process improvement team
- Enhance Office of Technology Transfer
- Enhance GCRC
- Expand education and training through K30
- Create Research Resource Inventory

## Pre-CTSA

- GCRC
- Precursor began operations in 1940s
- One of 8 initial GCRCs—first funded in 1960
- Since start of CTSA: 14% increase in active protocols and 15% increase in first time Principal Investigators
- K30
- Funded in 1998; renewal in 2005
- 153 trainees accepted through 12/2007
- Results:
- 75 completed; 49 in progress; 72 MPH degrees conferred
- $22 million in new grant funding
- 349 first author publications
- 15 individual K awards

## Research Resource Inventory

## Research Resource InventoryTranslational Research

- T1: Does this project involve applying basic science results to develop new diagnostic or therapeutic procedures in patients with specific health concerns?
- T2: Does this project involve testing the safety or efficacy of drugs or devices in specific patient groups?
- T3: Does this project involve testing drugs, devices or other interventions in community settings to establish effectiveness and efficiency?

- Percentages reflect 1154 projects for which responses were available, out of a total of 1388 research and other projects.

## CTSI Organization

## External leverage

- Clinical and Translational Science Building
- #1 University priority for 2007
- NYS Governor announced $50 million to support construction
- Upstate Consortium
- Pilot program funding - $150,000 contributed by Foundation for Healthy Living (Albany)
- IRB collaboration to simplify multi-institutional reviews
- National Clinical Research Associates: supplemental grant from NCRR

## University of Rochester Medical Center

**Notes:**
Firm Intro connectivity

## Clinical Translational Science Building

## Site Plan“Torque” Scheme

- Site Plan“Torque” Scheme

## Francis Cauffman

- Aerial Perspective – 4 Story Base Building“Torque” Scheme, view toward southwest

## =

- Francis Cauffman

- Community Planning Diagram

**=**

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## Center for Governmental Research:Economic Impact of the CTSA

- Total economic impact (steady state):        $30 million/yr; about 600 jobs
- Building construction impacts:
- 	- Labor income:  $43 million
- 	- 830 person-years of full-time labor

## Upstate New York

**Upstate New York**
**Translational Research Network**

- Proposed new members:
- Roswell Park, RPI

## CTSI Key Function:Upstate New York Translational Research Network (UNYTRN)

**Accomplishments:**
- UNYTRN Webpage
- Inventory of translational research and research resources
- Eight working groups convened
- Human Subjects Working Group developed memorandum of understanding to simplify multi-institution IRB submission
- Pilot Studies Working Group
- Solicited pilot study proposals (2/19/07), 10 Applications received, 3 funded
- Total funds:  $170,000 ($20,000 from CTSA, $150,000 from Foundation for Healthy Living)

## Internal leverage:Academic impact

- Enthusiasm/Collegiality
- Active Key Functions - 45 faculty with effort on grant
- Willing volunteers – *e.g.: >80 reviewers for pilot study projects*
- Training and Career Development
- 18 T32 trainees; 7 K12 scholars selected (3 have now received other career dev. awards)
- Nanotech Symposium; Stem Cell Symposium
- Mentor Development Program
- New Directions
- 8 pilot awardees; 3 novel methods projects; 8 technology access awards; 3 upstate consortium pilots

## Financial Challenges	-Revised budget guidelines	-Carry-over process	

## Impact of revised budget guidelines

- GCRC and K30 Budgets (2006)		$2.8 million
- GCRC and K30 Budgets (2011)*		$3.4 million
- 								$0.8 million
- CTSA Re-budgeted (2011)			$4.2 million
- __________________________________
- *4% escalation rate

## Financial Issues

- 2011 incremental funds		$0.8 million
- 2011 CTSA needs
- 	K12 mentored career awards 	$1.5 million
- 	T32 training awards			$0.8 million
- 	CTSA Key Functions				??

## Carry-over Issues

- Long delays (6+ months) result in uncertainty for current projects awaiting  carry-over approval
- Inability to plan for future years
- Inability to implement training, pilot, and novel methodology key functions
- Loss of momentum and enthusiasm

## University of Rochester Medical Center

**Notes:**
Firm Intro connectivity