BEE-spoke-data/govdocs1-by-extension huggingface dataset:
# Presentation: 730639

##  Regional Collaborative ActionJohn ParrAlliance for Regional Stewardship/Center for Regional and Neighborhood Action

*Regional Collaboration: *
*Learning to Think and Act Like a Region*
*April  24, 2003*

## Integrating Regional Conversations

## Regional Stewardship in Action

## Stages of Regional Change

## Why Use Collaboration?

- Parr’s Principles
- People act out of Self Interest
- You cannot understand others unless you know them and talk with them
- People are not stupid
- This is hard, time-consuming work, but you have to do it fast
- The beginning is the most important step

## Why Use Collaboration?

- There’s a gap.
- It might be a crisis now, or it could be.
- The lack of resolving this is hurting me.
- We have tried everything else.
- This issue is _really_ complex.
- There are too damn many people involved.
- Someone else will do it to it to us if we don’t.
- The burdens aren’t that bad.
- There are benefits.

## Lessons Learned

- Build momentum for collaboration, but then get started on something!
- Balance top-down influence with bottom-up innovation.
- Encourage big ideas and achievable first steps.
- Its about the network—people, ideas, and relationships—not institutions.

## New Coalitions for Change

## Team of Regional Stewards

- Integrators—share perspective about linked economic, environmental, social objectives
- Connectors—bring people together across worlds, “boundary crossers”
- Communicators of Possibility—raise aspirations, articulate potential, persuade

## Pattern of Long-Term Stewardship

## John Parr, President/CEO

- 1009 Grant Street
- Suite 203
- Denver, CO 80203
- (303) 477-9443
- (303) 477-9986 fax
- jparr@usa.net
- www.regionalstewardship.org
# Presentation: 534207

## Neil Flanzraich

***Neil Flanzraich***
***Vice Chairman and President***

***Pulmonary-Allergy Drugs Advisory Committee Meeting***
***June 10, 2004***

## IVAX Corporation

- Multinational Corporation
- Leading Generic Company
- Albuterol Inhalation Aerosol (CFC)
- Verapamil HCl ER Tablets
- Paclitaxel Injection
- Extensive Proprietary Drug Pipeline
- Strong Focus on Products for Respiratory Conditions

## Leader in Providing Generic Albuterol Inhalation Aerosol (CFC)

- First U.S. Generic Albuterol Inhaler
- FDA Interactions – Establishing Guidance
- Expanded Use of Albuterol
- Significant Reduction in Price

## Leader in Providing CFC-Free Branded Respiratory Products

- IVAX’ 17-year Commitment to Development
- World’s First CFC-Free Beclomethasone in MDI
- QVAR – First CFC-Free Aerosol Corticosteroid for Asthma in U.S.
- NDA Filed Jan. 2003 for HFA Albuterol in MDI (Received Approvable Letter 11/28/03)
- NDA Filed Aug. 2003 for HFA Albuterol in IVAX’ Patented Breath Activated Easi-Breathe® Inhaler
- IVAX’ Other CFC Alternatives
- Dry Powder Inhaler AirmaxTM
- Inhalation Solution Products for Nebulization

## Health Concerns

- Depletion of Stratospheric Ozone Health Risks
- Increase Formation of Ground Level Ozone Health Risks

## IVAX’ HFA Albuterol MDI and HFA Albuterol Easi-Breathe

- Will Meet FDA Regulations on Same Active Moiety, Same Route of Administration, Same Indications and Approximately Same Level of Convenience of Use
- Will Provide at Least One Year of Post Marketing Data on Equivalent HFA Albuterol Products Sold in Europe

## IVAX’ HFA Albuterol MDI and HFA Albuterol Easi-Breathe

- Capacity
- FDA Approved Plant in Waterford, Ireland
- 50-60 Million Units a Year in the Near Term
- CFC Availability is Rapidly Decreasing in Europe

## IVAX and Pricing

- 17 Years of Demonstrated Commitment to Affordable Medicine – Generic and Branded Products
- Substantial Free Sampling Program
- Patient Assistance Program
- Additional Competitors Create Downward Pricing Pressure

## IVAX Request

- Based on:
- Continued CFC Hazards
- FDA Criteria for Removal Now Met
- Huge Industry Investments
- US Pledge to Citizens and International Community
- IVAX Request:
- Removal of Essential Use Exemption, Effective no Later than Dec. 31, 2005

## Slide 10
# Presentation: 396283

## Poison Ivy

- What to look for...

## Jamie Stalker, MD

- Argonne Medical Department

## Plants

**Toxicodendrons**
- Poison Oak
- Poison Sumac
- Poison Ivy

## Some Little Known Facts About Poison Ivy and Its Cousins

- Everyone has the potential to react
- Urushiol is the chemical culprit
- Urushiol is within the plant, not on the surface
- Urushiol can remain active in dry conditions on surfaces for up to a decade
- Urushiol must penetrate the skin

## The Reaction

- Rash (**Rhus dermatitis)** only occurs where Urushiol contact and absorption has occurred
- Rash cannot spread!
- Rash occurs in 24 to 48 hours (first time reactors may take 7-10 days)
- Redness and swelling followed by blisters and itching
- Rash and blisters disappear in 14 to 20 days without treatment

## Slide 6

## Slide 7

## Slide 8

## Can We Prevent Poison Ivy?

- Eradicate plants
- Avoid areas in which the plants grow
- Wear clothes that cover your skin
- Cleanse skin and clothes with alcohol and water
- Ivy Block

## Ivy Block®

- Approved by FDA
- Apply 15 minutes before exposure
- Lasts 4 hours
- Active ingredient bentoquatam reacts with urushiol and blocks reaction
- Cannot be applied over rash

## How to Cleanse Properly

- If exposed, try to remove within 10 minutes
- Initially cleanse areas with rubbing alcohol
- Then rinse skin with water
- Then take a shower with soap and water
- Tecnu®
- Remember to clean surface of clothes, shoes and other contaminated items with alcohol and water

## First Aid for Poison Ivy

- For mild cases, wet soaks and cool compresses
- Oral antihistamines for severe itching
- Topical corticosteroids for relief
- Oral steroids for severe reactions for at least 3 weeks
- Drying agents for blisters (Calamine, etc.)
- New product – Zanfel®

## Slide 13

## Slide 14

## Slide 15

## Slide 16

## Slide 17

## Slide 18

## Poison Ivy?

- No 	 - This is a Texas wild legume

## Poison Ivy?

- No – This is Virginia Creeper

## Poison Ivy?

- No – Look Alike Bramble

## Poison Ivy?

- No – Box Elder

## Poison Ivy?

- YES!
- Leaves of three, leave them be....

## Be Safe and Have a Injury Free Summer!
# Presentation: 735693

## Commercial sales exceed $1 million 

**High Speed, Compact Spatial Light Modulator**

**S**mall
**B**usiness
**I**nnovation
**R**esearch

**Boulder Nonlinear Systems, Inc.**

- Lafayette, CO

**INNOVATION**
- Increased performance and resolution in a
- compact 512 x 512 spatial light modulator
**ACCOMPLISHMENTS**
- First 512 x 512 display with 7 micron spacing with 1000 frames per second capability
- Ferroelectric liquid crystal technology provides high resolution, high contrast imaging
**COMMERCIALIZATION**
- Commercial sales exceed $1 million
- Applications include optical correlators, volumetric 3-D displays and several more technical areas

**GOVERNMENT/ SCIENCE APPLICATIONS**
- Boulder Nonlinear Systems spatial light modulators have been used to construct optical correlators for efficient target recognition
- Technology under development for NASA small bodies exploration and Mars sample return missions

***Optical Correlators Can Provide Fast, Efficient Location Recognition for Spacecraft Docking and Landing***

- Jet Propulsion Laboratory
- Success Story #64

- 1997 Phase II; NAS3-99133
- NASA/JPL Contact – Tien-Hsin Chao
- Company Contact – Kip Bauchert
# Presentation: 293998

## CCFHR research on the NOAA ship Nancy Foster

**CCFHR research on the NOAA ship *****Nancy Foster***

**NOAA/NOS/NCCOS**
**Center for Coastal Fisheries and Habitat Research**
***Nancy Foster***** user meeting, Charleston, SC Nov. 15-16, 2006**

## National Centers for Coastal Ocean Science

- CCEHBR
- Jeff Hyland
- CCFHR
- Mark Fonseca
- Jud Kenworthy
- Paula Whitfield
- CCMA
- Tim Battista/Coral program

## Puerto Rico/Vieques (Kenworthy)

- Overall project ~10 years; NOAA ships since 1999?
- Seagrass surveys
- Storm disturbance
- Manatee grazing
- Fish/habitat surveys

## Invasive lionfish (Whitfield)

- Since 2004
- Planned deco diving
- Population surveys
- Site assessments
- Reproductive status
- Gut contents
- Population genetics

## Tortugas (Fonseca)

-  Effects of MPAs
-  30 permanent sites, 10 per strata
- Divers
- Acoustics
- Remote sensing
-  bottom trawls
-  since 1999

## Initial cruise in FY06
Habitat characterization
Artisanal fishing
Mapping
Stable isotopes
Conch

- Initial cruise in FY06
- Habitat characterization
- Artisanal fishing
- Mapping
- Stable isotopes
- Conch

**Navassa (Piniak)**

## Issues/concerns

- Transparency in ship scheduling
- Coordination with other agencies
- Shortfall planning
- Allocations
- Transit times
- Priorities by programs
- Capabilities
- Launches with GPS and depth finder
- Compressor
- SWMB/additional survey tech capacity?
- Scientific personnel

## Questions?
# Presentation: 016086

## Priority Analysis Plans in the Women’s Health Initiative:What’s Left to Learn?

- Robert B. Wallace, MD
- University of Iowa
- College of Public Health

## Continuing Other WHI Trial Components

- Estrogen only trial
- Dietary modification trial (low fat/ high fruit/vegetable/fiber)
- Calcium/ Vitamin D intervention
- Overlap of all interventions

## Analysis of Intervention Overlap

- Estrogen/ progestin + Diet
- Estrogen/ progestin + Ca/Vit D
- Estrogen/ progestin + Diet + Ca/Vit D
- Same for Estrogen alone

## Completing the Analysis of the Estrogen + Progestin Trial

- Repeating analyses with completed endpoints in place
- Evaluating the health consequences of E + P withdrawal
- Considering the early withdrawals and crossovers; a “per protocol” analysis
- More detailed look at measures of quality-of-life and alternate global health indices

## Assessing Risk Factors, Risk Groups and Mechanisms of E + P Effects

- The early versus late events: heart attack, stroke
- The roles of general risk factors on outcomes:
- Age groups
- Minority populations
- Obesity
- Cardiovascular risk factors
- Primary outcomes already in place
- Other clinical conditions (“co-morbidity”)
- Biomarker studies in E + P intervention groups: genetic, biochemical, coagulation

## E + P: Ancillary Studies in Place

- WHI Memory Study: Altering the risk of dementia and Alzheimer’s Disease
- WHI Cognitive Assessment: Concurrent effects on a range of important cognitive functions
- WHI Sight Examination: Impact on macular degeneration and other retinal conditions

## E + P: Potential Impact on Other Important Outcomes

- Outcomes potentially suggested by epidemiological studies:
- Gall bladder and other biliary tract diseases
- Degenerative arthritis and joint replacement
- Urinary and sexual function
- General  physical function—”healthy aging”
- Outcome contrasted with those of the WHI Observational Study
# Presentation: 245962

## Puerto Rico

*In*

*Puerto Rico*

- Center for Sustainable Development Studies
- School of Environmental Affairs
- Universidad Metropolitana (UMET)
- San Juan, Puerto Rico

*(SLUPR)*

## The development of a GIS scientific model

**The development of a GIS scientific model**
**with a land use sustainability  index that will**
**provide a tool to measure and monitor the impacts in Puerto Rico of the progression of **
**the urban built environment on:**
** ****quality and availability of land**
** ****ecosystems**
** ****water **
**for long term regional sustainability ****(Caribbean)**

##  Debate on unsustainable land use pattern 

** ****Debate on unsustainable land use pattern **
**  ****(urban sprawl) **
** ****Scarcity of land:  **
** ****8,874 Km****2**** **
** ****4 million inhabitants**
** ****Population density of 429 individuals per Km2 **
** ****Projected population growth rate per year of 0.6%**
** ****Research study **_***Puerto Rico’s Road to Smart   ***_
***  ***_***Growth***_** revealed that the whole island could **
**  ****become a suburban megalopolis within 75 years. **

**BACKGROUND**

## The following steps will be followed to develop the model: 

**(1) Site characterization and assessment**
**(2) GIS data collection**
**(3) Analyses of analog maps, aerial photographs,  **
**      ****and satellite data**
**(4) Data integration for sustainability index  **
**      ****determination**
**(5) Analysis of outcomes**
**(6) Documentation of findings **

**METHODOLOGY**

##   Data:		  1980-2004

**  ****Social: ****	****	****  Population**
**	****	****	****	**** ****	****  ****Population Growth Rates**
**	****	****	****	****	****  ****Housing Units**
**	****	****	****	****	****  ****Urban Settlements **
**	****	****	****	****	****  ****Income**
** **
** ****Environmental: Land Use / Cover**
**	****	****	****	****	****  ****Area of Main Ecosystems**
**	****	****  ****Protected Areas/Total Area**
**	**** **
** ****Economic:****	****  Number of Vehicles**
**	****	****	****	****	****  ****Journey to Work**

**MAIN VARIABLES**

## Development of a GIS model with a LU 

**	****sustainability index (within a tropical **
**	****island scenario) to measure land use patterns and tendencies that will apply to local municipalities, as well as other islands in the Greater Caribbean Region and other similar environments. **
**2)  Development of **_***Puerto Rico’s Annual State of Land Use for Sustainability***__** Report**_** by UMET where municipalities will be ranked according to land use. **
**3) Expand EPA’s National Center for Environmental Research portfolio of geographic regions, resources, systems and scientific approaches for further research.**

**EXPECTED RESULTS **
# Presentation: 042681

## National Sea Grant Office

- Extension
*Liffmann*

- Communications
*Painter*

- Research *Carlson/Hurley*
*(AIS – Harmon/Pearson)*
*(Aquaculture – Lazur)*

- Education
*Walker*

**National Sea Grant Office**
**Organization**

- New England, Mid-Atlantic & Great Lakes
- Team Lead - Carlson

**Focus Areas**
- Fisheries – Smith
- Aquaculture – Lazur
- Seafood Safety – Smith
- Invasives – Carlson, Pearson
- Ecosystems – Vacant
- Resilient Communities – Liffmann, Garber
- Biotech/Ocean and Human Health – Vacant
- Technology/Ocean Obs – Carlson
- Social Sciences/Economics - Smith

- Grants/Contracts/Budget
*Taylor, Garber, Lugo*

- CFO
*Eigen*

- Office Administration
*Barrera, Robinson*

- Assistant Director
- for Administration
*Garber*

- National Competitions Coordinator
*Vacant*

**Operations**

**Finance**

**Program Planning & Assessment**

- Southeast & Caribbean, Gulf of Mexico, & Pacific
- Team Lead - Vacant

**Program Leadership & Coordination**

**National Leadership & Coordination**

**Great Lakes**
*Michigan*
*Lake Champlain*
*Illinois-Indiana*
*Minnesota*
*Ohio*
*Wisconsin*
*New York*
*Pennsylvania*

**New England**
*Maine*
*New Hampshire*
*Rhode Island*
*Connecticut*
*M.I.T. *
*Woods Hole*

**Mid-Atlantic **
*Maryland *
*Delaware*
*New Jersey*
*Virginia*

**Southeast & Caribbean **
*Georgia*
*North Carolina*
*Puerto Rico*
*South Carolina**	*

**Gulf of Mexico**
*Florida*
*Louisiana*
*Mississippi-Alabama*
*Texas*

**Pacific**
*Alaska*
*Oregon*
*Southern California*
*Washington*
*California*
*Guam*
*Hawaii*

- Team Lead

- Program Planning & Assessment
*Grimes*
# Presentation: 375939

## New physics and quark flavor phenomenology- a “new age” matrix

| New Physics | Experimental strategies | The SM background |
| --- | --- | --- |
| Susy - MSSM | Measure sides -Vcb, Vub,Vtb Vcd, Vcs, | Short distance dynamics |
| SUSY- Rparity | Measure angles
does the triangle close?
Several different measurements of the same variable (e.g. sin2 from Ks and Ks); different sindeterminations | Long distance dynamics:
a hurdle?
A help? |
| Extra dimension | Unitarity constraints: Silva Wolfenstein check |  |
| 2 Higgs et al | Mixing (B,Bs) |  |
| Non commutative geometries | Direct CPV (new phases?)
-B decays; charm decays |  |
|  | Other discrete symmetries (CPV) |  |
|  | Rare decays (K,B,D,t) |  |

****

## Higgs sector and flavor physics

- Strategy “across the models” (many ESM predict an enlarged Higgs sector)
- Minimal extension 2HDM: 3 scalar (h0H0 CP even and A0 CP odd)  + 2 charged H
- CPV in  t W+b
- CPV in b sb sl+l-
- CPV in D0K-
- Neutron EDM
- Charm and beauty decay constants (H)
- Lepton # changing processes

## Action plan

- Stack of papers to read: try to identify unique signatures
- Explore the relationship with Higgs sector in SUSY
- Compare with Standard Model predictions
- Explore “information content” of the signatures: relationship with our understanding of the process of electro-weak symmetry breaking and origin of flavor.
# Presentation: 411382

## LUNCH

**5-1**

**Training of Trainers  **

**LUNCH**

- Community meeting
- CPIT presentations

- CPIT presentations
- Next steps
- Logistical information
- Wrap-up and evaluations

## Deliver parts of trainings with your mentor

- Evaluation
- Certification!

**5-2**

**Training of Trainers  **

## Before a training:

- •	Communicate with mentor.
- •	Get training assignment.
- •	Prepare to deliver assignment.
- •	Ask questions.
- •	Arrange for pre-training meeting with mentor.

**5-3**

**Training of Trainers  **

## Bring training materials and supplies.

- Arrive at the time agreed upon with lead trainer.
- Assist with room setup and break down.
- Assist with greeting participants and answering questions.
- Support the training team.
- Deliver assigned material.
- Debrief with training team.

**5-4**

**Training of Trainers  **

## Keep up-to-date in prevention field.

- Continually work to improve performance.
- Present a professional image.
- Uphold a high level of ethics.
- Address problems openly and appropriately.
- Submit all paperwork on time.

**5-5**

**Training of Trainers  **

## Assessing a community’s readiness for the next training

- Assessing a community’s readiness for the next training
- Lead Trainer Checklist
- Pre-training information in Trainer’s Guides

**5-6**

**Training of Trainers  **

## Service Report

- Sign-In Sheet
- Participant evaluation forms
- Invoice
- Expense report
- Trainer Evaluation forms

**5-7**

**Training of Trainers  **

## Answering Tough Questions

**5-8**

**Training of Trainers  **

- Answering Tough Questions
- Icebreaker Resources
- Forms and Checklists
- Further Reading

## 5-9

**5-9**

**Training of Trainers  **
# Presentation: 164745

## Some Considerations on Yield Stress:A Modeler's Perspective 

- Nicos Martys
- NIST

## Why study the rheology of concrete?

- Concrete is the most widely used building material.
- Ease of flow and placement can significantly reduce costs.
- Architectural benefits: Improving workability and mechanical properties allows for  more flexibility in design.

## Viscosity = 

- V

- L

- F**/**A

- F/A

- V/L

- F = applied force
- A = area
- V = velocity
- L = gap width

## Yield Stress

- V=0

- L

- F**/**A

## Slide 6

##   Interaction potential

## Model:Measurement

- Bingham model
- Hershel Buckley:
- Modified Casson Equation:

- .

##             Stress Growth

- 100
- 10
- 1
- .1
- .01
- .005

- v

##  Bingham Model 

## Low Shear Rate Limit

##       Comparison of models

- Brinkman

- Hershel Buckley

- Casson     q=p=2

##   Role of force vs. potential

##   Stress Growth-Raw Data

- V/KT

- 40
- 40
- 10

- 5

##          Scaled Data  (I)

##           Scale Data  (II)

## Radial distribution function:V(r)

## Radial distribution function for scaled potential: V(3r) 

## Observations on Yield Stress

- 1)Over small strains (<<1) stress growth simulation data can be collapsed using maximum force and interaction potential width as scaling parameters (at fixed concentration).
- 2)Over larger strains (~0.1) entropic barriers begin to complicate analysis.

## Mean Squared Displacements         Volume fraction=0.52

- Conrad and Weitz

##                Yield Stress?

-                Yield Stress?

- V=1
- V=.01

## Some possible questions...

- 1)Further validation steps?
- 2)What are the most reliable measurements to compare to?
- 3)Other improvements?
- 4)Potential use of AFM or other methods to determine inter-particle forces.

## Realistic interaction forcesNonat et al.

## Cement Particles

## Cement Particles

- N       N

## Yield Stress vs. Volume Fraction 

- Flatt and Bowen

## Acknowledgements

- Ray Mountain: Numerical algorithms
- Julien Lancien, Jim Sims and Bill George: parallel code development
- Steve Satterfield, John Hagedorn and Tere Griffin: visualization
- Ed Garboczi: realistic aggregate shapes
- Clarissa Ferraris, Robert Flatt (Sika),Vijay Gupta (W.R. Grace), David Fowler (ICAR), John Winpigler, Daniel Constantiner (Degussa)
- VCCTL, ACBM
- NASA

## Sheared Cubes

## Spheres and Cubes

- Open symbols:simulation
- Filled symbols:Experiment
- Koehler and Erdogan

##        Revisit Bingham Model

- Y=8
- Y=3
- Y=1.6
# Presentation: 797326

## Trilinos SQA Update

- Robert Heaphy
- James Willenbring
- Trilinos User Group
- Monday, October 31st, 2005
- 2:15 – 3:15 pm
- Building 980, Room 95, Albuquerque

## Topics

- - General SQA Update
- - Documenting Requirements and Design
- - Software Engineering Seminar Series
- - Plan, Do, Check, Act
- - A New Tool: Wiki
- - Discussion

## General SQA Update

- Bob Heaphy

## Documenting Requirements and Design

- - Very important for ASC
- - The Trilinos approach is not currently clear
- - Need to document what we do/are going to do
- - Developer meetings
- - UML diagrams
- - Mail list discussions
- - Bugzilla
- - Doxygen
- - All packages do not have to take the same approach
- - Document and follow
- - Produce artifacts periodically
- - Formal design document as project matures?

## Software Engineering Seminar Series

- Counts for ASC training
- (I have been told) attendance has been low

## Plan, Do, Check, Act

- - Has helped to improve release process checklists
- - What checklists exist (other than release checklists)
- 	- Strongly consider using Plan, Do, Check, Act
- 	- We should post all checklists on website

## A New Tool: Wiki

- - Mike P found a new tool that might help with requirements and design
- - _[http://software.sandia.gov/trilinos/wiki](http://software.sandia.gov/trilinos/wiki)_
- - Please suggest any others you know of

## Discussion

- Improving our SQA processes and practices
# Presentation: 438684

## Large Area Detector for Radiographic Measurements 

**ACCOMPLISHMENTS**
-   Developed scatter-rejection techniques that resulted in 98 	percent improvement in contrast and 40 percent 	improvement in detective quantum efficiency
-  	Developed prototype detector and integrated it into a real-	time radiography system for observing materials while 	stressed in a load frame
**COMMERCIALIZATION**
-  	Detector technology incorporated into the KonoscopeTM 	volumetric x-ray computed tomography systems
-  	KonoscopeTM sales have reached almost  $2,500,000.  	These are to Wright Patterson Air Force Base and the 	University of Utah

***Advanced Research and Applications Corporation***
***Sunnyvale, CA***

**S****mall**
**B****usiness**
**I****nnovation **
**R****esearch**

**GOVERNMENT/SCIENCE APPLICATIONS**
-  	Useful in development of advanced composite materials 	and in rapid prototyping/reverse engineering
-  	For use in dimensioning of complex parts

- Glenn Research Center
- Structures
- 3-060

**Large Area Detector for Radiographic Measurements**** **

***Aluminum casting (left) and the corresponding volumetric 3D image***

**INNOVATION**

- 1991 Phase II, NAS3-26986, 11/00
- NASA Contact – George Baaklini
- Company Contact – Robert Frankle

- An imaging detector system for non-destructive evaluation that has greater resolution, higher contrast sensitivity and wider dynamic range
# Presentation: 793776

##  What is the Price-Anderson Act, and      why do I cringe every time someone mentions it?

- DOE Contractor Purchasing Managers Council
- October 26, 2000

## A Little Bit of History

- In the beginning....
- Electric Utility Industry (Three Mile Island)
- AEC/DOE Contractors

## Now What ???

- Price Anderson Amendments Act of 1988
**Quid Pro Quo**
*	**	**Multi-Billion Dollar Idemnity*
*       **Matter of Right*
*      **Civil and Criminal Penalties*
**Hazards Indemnity Agreement Clause**
-          *DEAR 952-250-70*
*     *

## Is This Going to Hurt?Enforcement Regulations

- Do _not_ want Violations/Events
-      Do want Assessments (Recognition/Correction before       Event)
- Requirements Definition/ Statement of Work
- Qualification of Prospective Contractors
- Inspection and Acceptance/
-      Quality Assurance

## SUMMARY

- Price-Anderson Act is a good thing!
- Enforcement process should be used to trigger safer performance before the fact!
# Presentation: 428640

## Cluster BIOS Proposal – Richard Ferri

- Problem Statement:  BIOSes were created largely in the early 1980s,
- largely for DOS systems. These BIOSes are largely unsuited
- for today's clusters
- The  BIOS model is that there is an operator attached to the keyboard
- on every machine, monitoring messages, navigating menus, etc.
- It's been really really convenient for BIOS writers and manufacturers
- to use the same  BIOS in workstations and in nodes that sell
- for cluster computing
- We try to solve cluster problems on workstation  BIOSes --
- Collecting MAC address, bootlist manipulation, error logs, etc.
- The BIOS we use is based on the workstation model --
- We need a new BIOS model for clusters

## Cluster BIOS Proposal – Richard Ferri

- Introducing -- ClusterBIOS
- ClusterBIOS is an API so that programs can talk to any ClusterBIOS
- certified hardware in the same way.
- Manufacturers will provide compute nodes that adhere to the
- ClusterBIOS standard
- OR --
- A project like LinuxBIOS will support the API

## Cluster BIOS Proposal – Richard Ferri

- Initial ClusterBIOS methods might be:
- -- What is my MAC address?
- -- Give me the error log
- -- What is my bootlist?  Set the bootlist
- -- Power on/off reset
- -- Flash the BIOS using this provided file
- -- What level is my BIOS?
- Eventually, extend to things like:
- -- Membership services

## Cluster BIOS Proposal – Richard Ferri

- PROPOSAL:
- That we investigate the appropriateness of a ClusterBIOS
- as part of the installation/configuration project team
- Contact the LinuxBIOS guys for comments
# Presentation: 669405

## General Status of STAR pp run as of June 1, 2005.

- General Status of STAR pp run as of June 1, 2005.

- 5.59 pb-1 delivered
- ~1.78 pb-1 sampled

- 292 nb-1 delivered
- ~ 93 nb-1 sampled
- (93/180 ~ 52%)

- N.B. 5.59 pb-1 @ 40% ~ 143 nb-1
- N.B. 1.78 pb-1 @ 40% ~ 46 nb-1
- N.B. 7 pb-1      @ 40% ~ 179 nb-1

## General Status of STAR pp run as of June 1, 2005.

- General Status of STAR pp run as of June 1, 2005.

- 2992 kevts total

- 12.80 Mevts total

## FOM plots through June 1, 2005.

- Goal = 180 nb-1 Sampled FOM

**Sampled FOM ~ 93 nb-1**

## General Status of STAR pp run as of June 1, 2005.

- General Status of STAR pp run as of June 1, 2005.

- Physics DAQ Hrs/wk:
- April 17th-23rd - 43.5 hrs		May 22nd - 28th - 54.3 hrs
- April 24th-30th - 37.0 hrs                       May 28th - 31st  - 22.1 hrs*
- May 1st - 7th     - 37.7 hrs
- May 8th - 14th   - 40.3 hrs
- May 15th-21st   - 47.3 hrs		* = Incomplete week

##  Success or failure, STAR wants to go back to the 200 GeV Spin physics running no later than Friday afternoon, June 3rd.

-  We’re currently ~ 10 wks past the start of the FY05 proton running (March 24th).
-  We’re ~ 6.5 wks into the proton Physics run (April 19th).
-  We have ~ 3.2 wks left in the run (June 25th, Question: Are we actually planning to end on a Saturday?).
-  Our best week of the run so far, we sampled 30 to 35 nb-1 of FOM.
-  If we get 3 more wks, ***similar or better than the best week***, we’ll just reach our longitudinal pp goal of sampling ~ 180 nb-1 of FOM (currently at ~ 93 nb-1).
-  Our goal of sampling 4 pb-1 of transversely polarized beams will clearly not be achieved this year. Discussions within STAR of whether to run transversely polarized beams for a modest number of days (e.g. 3 to 5) at the end of the run are taking place as we speak.
- As the Collider Physicists believed that this dev. work had to happen this year, STAR supported using up to 10 shifts (i.e. 8 am Tuesday May 31st to ~ 4 pm Friday June 3rd) to attempt to accomplish the goals in Mei’s “Energy Ramp” dev. Plan. This includes any running for the experiments.
-  Success or failure, STAR wants to go back to the 200 GeV Spin physics running no later than Friday *afternoon*, June 3rd.

## 10 hr store, from May 30th to May 31st. How do get more of this?

**BBC Coin.**
**BBC Yellow back.**
**BBC Blue back.**
**ZDC Coin.**

- 62 bunch pattern
- Fill# 7172

- <P>Y = 46%
- <P>B = 59.2%
- Int.L ~ 160 nb-1
- FOM ~ 11.85 nb-1 (Sampled ~ 5 nb-1)
# Presentation: 333203

## Passage of

- EPACT

## Industry Has An Excess of Permits to Drill

**Wells Started**

**Industry Has An Excess of Permits to Drill**

**APDs Approved**

- Source: Bureau of Land Management; answers to questions submitted for 3-1-07 hearing record.
- 2005 data incomplete.

## Federal Acres Leased and In Production – 2006

**Federal Acres Leased and In Production – 2006**

**(millions of acres)**

**42.8**

**12.3**

## Does More Drilling Lower Gas Prices? NO

**Does More Drilling Lower Gas Prices? **_***NO***_

**Price of Gas**

**# of wells**

## Do Higher Prices Lead to More Profits? YES

**Price of Gas**

**Oil Company Profits (billions)**

## Does Drilling More Lower Gas Prices? NO

**Does Drilling More Lower Gas Prices? **_***NO***_

**Price of Gas**

**# of wells**

- Price of Gas

- Drilling Permits
- Issued

- Wells
- Drilled

## How Much Natural Gas Is Currently Open to Leasing? 82%

- Undiscovered Technically Recoverable Reserves
- as determined by the Minerals Management Service, 2006.

**How Much Natural Gas Is Currently Open to Leasing?**** **_**82%**_

## How Much Natural Gas Is Currently Open to Leasing? 82%

- Undiscovered Technically Recoverable Reserves
- as determined by the Minerals Management Service, 2006.

**How Much Natural Gas Is Currently Open to Leasing?**** **_**82%**_

## How Much Oil Is Currently Open to Leasing? 79%

- Undiscovered Technically Recoverable Reserves
- as determined by the Minerals Management Service, 2006.

**How Much Oil Is Currently Open to Leasing?**** **_**79%**_
# Presentation: 174847

## Clinical Endpoint Bioequivalence Studies for Locally Acting Drugs

- Dena R. Hixon, M.D.
- Associate Director of Medical Affairs
- Office of Generic Drugs

## Systemic Drugs

- Delivered to the bloodstream for distribution to site(s) of action in the body
- BE determined with PK studies
- Relatively short studies
- Relatively little variability in results
- Relatively small number of subjects

## Locally-Acting Drugs

- Not intended to be absorbed into the bloodstream
- Delivered directly to sites of action in the skin, mouth, eyes, ears, nose, vagina, urinary tract, or gastrointestinal tract

## Locally-Acting Drugs

- Topical acne creams, lotions, or gels
- Topical or vaginal antifungal creams or suppositories
- Oral lozenges for oral candidiasis
- Ophthalmic drops for conjunctivitis
- Otic drops for external otitis
- Oral vancomycin for pseudomembranous colitis
- Nasal sprays for rhinitis
- Orally inhaled products for asthma

## BE of locally-acting drugs

- PK studies are not adequate
- Pharmacodynamic (PD) studies for
- 	topical steroids
- Most require clinical endpoint studies
- Combination products may require both PD and clinical endpoint studies

## Clinical endpoint studies

- 3-arm comparative trials of generic vs. reference listed drug (RLD) vs. placebo
- Treatment of an approved indication in a patient population according to the labeled dosing of the RLD.
- Trial design and endpoints similar to NDA

## Clinical endpoint studies

- Both generic and RLD must be statistically superior to placebo (p<0.05) in order to assure that the study is sensitive enough to show a difference between products.
- Same established BE requirements as for other types of BE studies

## Challenges of clinical endpoint studies

- Clinical endpoints more variable than PK but must meet the established BE limits
- May require several hundred patients
- Study duration may be several weeks depending upon the approved labeling
- Very expensive to conduct
- May present more safety concerns than PK studies

## Challenges of clinical endpoint studies

- Unknown inter-subject variability within reference population
- Difficulty in achieving consistency between studies
- study design
- study population
- bioequivalence endpoints
- Some products require multiple studies

## Dermatologic drugs

- Antifungals and other anti-infectives
- False negative baseline cultures lead to exclusion of many patients
- Acne products
- Multiple endpoints
- Often small effect size and low power to demonstrate BE
- Topical acyclovir
- Confusion about indications and endpoints
# Presentation: 698036

## Model-predicted vertical temperature change: II

- Joyce E. Penner1
- Minghuai Wang1, Leon Rotstayn2
- 1University of Michigan, 2CSIRO

## Observed trend (oK/decade) at surface and mid-troposphere (1979 - 2003)

- Can model-predicted
- tropospheric temperatures
- explain the observed
- pattern of temperature
- differences at the surface
- and mid-troposphere?

- Jones

- Biomass burning

- Fossil fuel soot

- FF + BB + SO4 direct

## Jones - Wentz

- Biomass burning

- Fossil fuel soot

- FF + BB + SO4 direct

## O3 trend from PCM model

## Global average change (PD-PI) (oK)

|  |  
Surface  |  
595  | Surface – 595   |
| --- | --- | --- | --- |
| Observed (oK/decade) | 0.18  | 0.11  | 0.04  |
|  |  |   |   |
| Fossil fuel soot  | 0.014 | 0.099 |  -.085 |
| Biomass burning |  -0.063 |  -0.058 | -0.004 |
| FF+BB+SO4(Direct-only)  | -0.259 | ... |  -0.093 |
| SO4(Indirect-only)  | -1.34 | -1.37 | 0.036  |
| 2xCO2-1xCO2 | 3.12 | 3.35 | -0.227  |
# Presentation: 551486

## Occurrence Reporting and Analysis

- Tom Rollow
- Director, EH Operating Experience Analysis (EH-33)

## New platform and software

- Old HP computer

- New DEC Alpha

**Notes:**
Old HP.  Every line of code hand written. Laborious process to make changes.  Many idiosyncrasies.

Down time last week - problem with running two systems - not synchronizing.

New DEC Alpha computer with COTS software - much more efficient, ease of upgrade and backfit.

## Old HP Shut Down

## ORPS 2000Major Re-engineering in Progress

- More intuitive customer interface
- Separate Reports and Corrective Action
- Integrate ORBITT and other canned reports
- Easier queries, easier customized reports, better graphical Reports

## ORPS Quality, Consistency, Compliance

- Quality Feedback Forms

## ORPS Quality, Consistency, Compliance

- Is everything being reported that should be reported?
- Need to better monitor corrective action closure and let sites know how they are doing
- Use ORPS for Performance Measures?

## ESH Information

- Information
- New EH Web Portal

## New EH Web Portal

**NEWS**

**TOPICS**

**MY EH**

## ESH Information

- Information
- New EH Web Portal
- ORPSCast

## ORPSCast

- Customer Profile

- Customer Profile
- Periodicity:  ____________
- Facility or site:  _________
- Nature of occurrence:  ____
- Fax or email:  ___________

- ORPS

- Customer email

- MY EH

## ESH Information

- Information
- New EH Web Portal
- ORPSCast
- Lessons Learned/Information Analysis

## Lessons Learned/Information Analysis

- Go beyond events, beyond ORPS
- Better IT system
- new corporate database
- link local databases
- Populated with valuable information
- ease of access
- aligned with work, hazard, trade, etc.
- Just the right info at right time

## Information Age

- Informed decision makers - Management by fact
- Demonstrate performance to others
- Remember the end use
- Think beyond ORPS, beyond data - analysis, other info sources

- We welcome your ideas
- Tom Rollow
- tom.rollow@eh.doe.gov
- (202) 586-7449
# Presentation: 800339

## Developing Tropical System

**Briefing #4**
**3:30 pm - 9/20/07**

## Summary

**Situation gradually becoming clearer**
**Satellite, observations, and recon data show that the low in the southeast Gulf continues to become better organized**
**Models and weather pattern are leading to more focus on the potential landfall**
***Southeast LA to SW Alabama***
**Timing a bit more uncertain, but impacts likely to begin late Friday night**

## Current Situation

**Better organized surface low centered about 100 miles west of Sarasota, FL**
***Central pressure 1004 mb***
***More thunderstorms closer to the center***
***Drifting WNW***

- L

## Track

**No official forecast track yet**
**Track models are now in decent agreement on landfall between SE LA and SW AL**
**Most likely for our area to have direct impact were this to verify would be late Friday night into at least Saturday**

**Model forecasts for system**

## Track and Timing

**Models generally show landfall around Saturday morning**
**System is still over 400 miles from MS coast**
***Based on 8 mph forward motion, system could not reach coast before early Saturday afternoon***
***Impacts would begin sooner (late Friday night)***

## Intensity

**Positives for intensification**
***Very warm Gulf waters; depending on track, system will pass very near “loop current”***
***Forecast weak wind shear over Gulf***

**Negatives for development/ intensification**
***Proximity to mid/upper level low pressure system***
***Dry air over the northern/eastern Gulf of Mexico***
***Uncertain length of time over water (longer over ocean, more intensity possible)***

- _Still uncertain_

## Potential Impacts

**Based on making landfall as moderate to strong tropical/subtropical storm**
***Heavy rainfall threat only in extreme south***
***Risk of tornadoes south of I-20, and especially in the Highway 84 corridor***
***Wind gusts of TS force possible south of I-20***
**Greater risk the farther south in the area**
**Speed obviously depends on ultimate strength of system**

## Points to Take

**Surface low becoming better defined**
**Models now indicating WNW movement in general direction of SE Louisiana**
***Most likely time for impact in our area would be from late Friday night into Saturday should the system develop and move as currently forecast by models***
***Most impact likely to be over the southern half of our service area (I-20 south)***
# Presentation: 511044

## Extinction Spectroscopy for Characterization of Particulate Matter Size and Concentration in Fugitive Plumes

- Dr. Ram Hashmonay
- ARCADIS
- 4915 Prospectus Dr., Suite F
- Durham, NC 27713

## Method Description

- OP-FTIR is an accepted method for gas measurements
- Particulate matter (PM) presence reveals a unique baseline structure (see below)

## Method Description (cont.)

- Baseline structure can be predicted for a given size distribution and optical constants using Mie theory
- We developed an inversion algorithm to retrieve the aerosol size distribution from extinction (scattering+absorption) measurements
- Optical properties (constants) of specific PM may be determined using a bench-top FTIR spectrometer

## Mie Theory

- Size Parameter **

*d* - particle diameter
** - wavelength

## Mie Theory (cont.)

- Complex Refractive Index

***n*** – scattering term (refraction and reflection)
***k*** – absorption term

*m(****) = n(****)-ik(****)*

## Mie Theory (cont.)

- Extinction Efficiency:

- Extinction efficiency of water in different part of the FTIR spectrum

## ei - extinction for the ith wavelength 

* **Q**e**ij*- dimensionless extinction efficiencies
* **N**j** *- number density for the *j**th* aerosol size
* **d**j** *- is the aerosol *j**th* size class (diameter)

- Extinction as Function of Wavelength

## Shower Experiment 

- OP-FTIR beam through water condensation aerosol
- Size distribution confirmed by aerosol probe
- Known optical constants (see below)

## Shower Experiment Results

## Predicted Smoke Extinction Spectrum

## Smoke PM Extinction

## Water Condensation Aerosol

## 2.5 m Mean Size; 2 m SD Gaussian Fit

## Sahara Dust Optical Constant

## Slide 15

## Landfill

- Dirt Road

- OP-FTIR Beam

## Slide 17

## Slide 18

## Slide 19

## Slide 20

## Slide 21

## Diesel PM

## Predicted Diesel Spectrum

## Diesel Extinction Spectrum

- 9 m

- 3.9 m

- 2.3 m

## Slide 25

## Slide 26

## Slide 27

## Slide 28

## Path-Integrated Lidar

## Enhanced Range Lidar

## Conclusions

- The first open-path optical technique to obtain real-time fugitive dust measurement and sizing
- Measurement of liquid aerosol like water or pesticide drift
- OP-FTIR can be used in field to gather multiple gases  and PM emission data simultaneously
- Extending the spectral range to the UV/VIS range will allow sizing of submicron PM
# Presentation: 329238

## How to Ensure Product Integrity in China

**NIST Standards in Trade Workshop for China **
**on Fire Protection for The Built Environment**
** ****20-24 September 2004**** **
**Gaithersburg MD US**
- Li Jian
- Shenyang Fire Research Institute
- 24 September 2004

## Roles in Ensuring Product Integrity

- Manufacturers(Suppliers)
- Conformity Assessment Organizations
- National Test Centers
- Architects(Designers)
- Fire Authorities
- Builder(Contractor)
- Organizations for supervision of Construction and Installation
- Organizations for acceptance Inspection

## Responsibility of These Roles

**Manufacturers(Suppliers)**
**    ****— ****Design and manufacture products,control the product quality according to related standards**
**Conformity Assessment Organizations**
**     ****-- Conformity Assessment and Certification**
**National Test Centers**
**     ****-- Test products  and issue Reports**** **
**Architects(Designers)**
**    ****-- Design building in accordance with codes**

## Responsibility of These Roles

- Fire Authorities
-     **-- Review the building design according to related codes and approve it, finally issue certification of occupation**
- Builder(Contractor)
-     **-- Construction and installation using compliant products, comply with codes**
- Organizations for Supervision of Construction and Installation(Not a part of fire authority)
-     **-- Supervision of construction and installation**
- Organizations for acceptance inspection and testing
-     -- **Inspection and testing, issue reports**

## Conditions

- Codes and Standards – issued and effective
- Certification(approval)
- Active surveillance system
- Confidence of manufacturers,designers and contractors

##   My Address

-    **Li Jian**
**   ****Shenyang Fire Research Institute **
**   ****Puhe Street 7, Huanggu Distrcit**
**   ****Shenyang, P.R.China 110031**
**   ****Tel. 86-24-86806012 **
**   ****Fax: 86-24-86806595**
**   ****E-mail **_[ljian@syfri.](mailto:ljian@syfri.cn)__[cn](mailto:ljian@syfri.cn)_

## 谢谢!THANK YOU!

**                 ****Questions?**

## 在中国如何保证产品的完整性

**NIST Standards in Trade Workshop for China **
**on Fire Protection for The Built Environment**
** ****20-24 September 2004**** **
**Gaithersburg MD US**
**厉  剑**
**公安部沈阳消防研究所**
**2004-09-24**
# Presentation: 464126

## eCTD Workshop

- February 26, 2004

## eCTD Specifications

- eCTD Backbone files (document file information)
- Module 1 (us-regional.xml)
- Module 2 to 5 (index.xml)
- Study Tagging File
- Comprehensive table of contents headings and hierarchy and mapping
- Other
- Study data
- Submission transmission

## Document File Information

- Subject matter
- title, table of contents headings
- Relationship to other files
- ties together files for a single report
- Life cycle
- new, replace, append, delete
- Location
- file path
- Submission information
- application number, submission number...

## Index.xml

- Modules 2 to 5
- Elements
- Heading element
- Leaf element
- ID - unique identifier
- operation - life cycle
- Modified-file - ID of previously submitted leaf effected by operation attribute
- Checksum and checksum-type
- xlink:href - location of file using file path
- title - title of document

## Heading Element

- CTD Table of contents headings
- Rules
- Some heading elements have no leaf elements
- Some heading elements include an attribute for further organization of files
- Don’t include headings if it does not have any files
- Additional heading elements and organizing attributes found in us-regional.xml and study tagging files

## Leaf Element - ID Attribute

- ID + application number + sequence number = unique identifier
- letter + number
- valid “a12345”
- not valid “12345”

## Leaf Element - Operation Attribute

- Values
- new - no effect on any file leaf in a previously submitted eCTD backbone file
- append - information in addition to file in a leaf in a previously submitted eCTD backbone file
- replace - file replaces a file in a leaf in a previously submitted eCTD backbone file
- delete - file contained in a leaf in a previously submitted eCTD backbone file should no longer be considered in the evaluation

## Leaf Element - Modified-file Attribute

- Location of leaf being modified
- Relative path and filename for the eCTD backbone file containing the modified file’s leaf element
- Example file submitted in sequence number 0000 replaced
- modified-file="../0000/index.xml#id12345 "

## Leaf Element - xlink:href Attribute

- Path of file associated with the leaf relative to index.xml file
- xlink:href="m5/tabular-listing-studies.pdf "

## Leaf Element - Title Attribute

- Title of file that is meaningful to reader

## us-regional.xml

- Module 1
- Admin element
- applicant-info element
- company-name element
- date-of-submission element
- product-description element
- application-number element
- prod-name element and type attribute
- application-information element and type attribute
- submission element and submission-type attribute
- sequence-number element
- related-sequence-number element
- Leaf and Heading elements

## Study Tagging File

- Supplements the document file information included in the index.xml file
- Relationship to other files
- Links files for a single report together
- Subject matter
- Study report title
- Study grouping (e.g., species, placebo control)
- Additional headings (e.g., synopsis)