# Presentation: 099248

## NIST: Promoting U.S. Innovation

**NIST: Promoting U.S. Innovation**
**and Industrial Competitiveness**
**Focus on Microfluidics**
- Clara Asmail
- Technology Marketing Program Manager
- Technology Services
- National Institute of Standards and Technology
- U.S. Department of Commerce

**Notes:**
Thank you Renee, and thank you all for coming tonight to our technology showcase.  

I especially want to thank the organizing committee and panelists for the efforts they have devoted to promoting NIST microfluidic technologies.

The National Institute of Standards and Technology – NIST -- is a non-regulatory federal agency within the Department of Commerce.  

## NIST patented technologies to be presented tonight :

- Microfluidics portfolio
- Simple High-Performance Biochemical Analysis
- Methods For Polymer Microfluidic Fabrication
- Microfluidic Mixing And Flow Manipulation
- Uniform Assembly Of Nanoliposomes
- Surface immobilization of biopolymers

**Notes:**
Next slides will provide background on the market potential for microfluidic technologies in general and hopefully motivate some of you to adopt the NIST’s technologies we will present tonight

## What are Microfluidics?

- 	Precise control and manipulation
- 	of very small fluid flows
- 		~ on the order of  microliters or nanoliters
- 	** a drop of water is approximately 25 microliters

## Microfluidics conserves costs in biomedical research

-    Small volume of fluids in microfluidic channels translates to:
- Small amounts of reagents and analytes used
-   &
- Integrated process steps – simpler, faster

**Notes:**

Miniaturization leads to reduced drug discovery R&D costs and decreased time to market 

By decreasing the amount of sample/analytes used --- process steps can be integrated and discovery is made simpler and faster

It is estimated that each day of delay in development time can correspond to between 1  and  3 million dollars in lost revenue 

## Industrial Applicationsfor instrumentation suppliers

- Pharmaceutical & Biotech	 $600 B
- Diagnostics		$30 B
- Medical Devices		$200 B
- Drug Delivery 		$91 B (by 2009)
- 					$220 B (by 2015)
*Emerging Markets for Microfluidics Applications*Geraldine Andrieux Gustin  Yole Development June, 2007

## Microfluidics:  Market size expectations

- 2005 global market for microfluidic technologies   ~ $2.9B
- by 2011 should grow to  ~ $6.2 B
- 	i.e., an average annual growth rate of 14.1%
*Microfluidics Technology*BCC ResearchSeptember, 2006

## Companies currently in Microfluidics market space:

| 3M | Caliper LS |
| --- | --- |
| Bartels mikrotechnik | Gyros |
| Boehringer Ingelheim microParts | Diagnoswiss |
| RainDance Technologies  | Dyconex |
| eGene | Eksigent Technologies |
| Fluidigm | Genesystems |
| Microplumbers | Nanogen |
| IQ micro | Wilden AG |
| Weidmann Plastics | Epigem |
| Micralyne Microfluidics chip shop | Micronics |
| Micronit microfluidics | Wasatch microfluidics |
| ThinXXS | SpinX Technologies |

**Notes:**
Micronics is a leader in the development of lab-on-a-card solutions – they’ve come up with near patient in vitro (Point of Care)  diagnostic products for disease diagnosis, prognosis and treatment monitoring. 
Micronics, Inc. announced this summer that it granted an royalty-bearing, worldwide license to its patented microfluidic-related technologies to Cleveland Biosensors (in Australia)
Also have a license out to Honeywell (up-front, royalties + development support under a Co-Promotion agreement)  

Control Products is part of Honeywell's Embedded Controls Business Unit - They provide solid-state sensors for position, pressure, airflow, temperature and current & have developed a portfolio of microfluidic technologies 

All non-exclusive licenses		per conv w Karen Hadine

Caliper collaborated w Agilent and have commercialized a product for quality control of DNA sorting 

Gyros has a flexible format product for Protein quantification -- allows for assays to be set up according to key parameters, such as sample availability, number of proteins to be assayed, cost of reagents, and throughput requirements. 

eGene has a product line of electrophoresis instruments used for pathogens detection and gene expression  - Irvine, CA

Microplumbers is a Modeling - Design - Fabrication - Testing engineering service for microfluidic systems  - Minneapolis &  Seattle

## Microfluidics: Critical market segments 

- drug discovery
- drug delivery
- in-vitro diagnostics
- ink jet printing *--- mature*
- chemical analysis
- high-throughput screening

## Microfluidics will enable

-  _efficient screening_
- of **more** **drugs** in **less time**
-  and **drastically cut down the costs**
- of drug development.

**Notes:**
BOTTOM Line

## NIST technology presentations

*Dr. David Ross*
- 	Simple High-Performance Biochemical Analysis
- 	Methods For Polymer Microfluidic Fabrication		Microfluidic Mixing And Flow Manipulation
- 	Uniform Assembly Of Nanoliposomes*	*
*	*
*Dr. Michael Tarlov*
*	**Surface Immobilization Of Biopolymers**	**	**	**	*