# Presentation: 362929

## NCI Breast Pre-Malignancy ProgramPresentation to the National Cancer Advisory Board

**NCI ****Breast Pre-Malignancy ****Program****Presentation to the**** National Cancer Advisory Board**

- Dinah Singer, Ph.D.
- Director, Division of Cancer Biology
- February 6, 2007

## Stamp-Out Breast Cancer Stamp Act

- Purpose:  Support breast cancer research
-     and raise public awareness about the disease
- Allows U.S. Postal Service to sell a special issue stamp with a surcharge above the first-class postage rate (current rate 45 cents)
- Authorized by P.L. 105-41 in August 1997 and reauthorized through 2007 by P.L. 109-100

- Background:

## Stamp-Out Breast Cancer Stamp Act

- 70% of donated funds allocated to the National Cancer Institute, NIH
- 30% of donated funds allocated to the Department of Defense Breast Cancer Research Program

## NCI Breast Cancer Research Supported via the Fund

- As of FY 2006, NCI received a total of $35.2 million
- Funds have supported two programs:
- Insight Awards to Stamp-Out Breast Cancer (Support of R21s- high risk research)
- Breast Cancer Research Stamp Act Awards
- 	(Funding of R01 proposals focused exclusively on breast cancer that were outside the pay line)
-  For FY 2007, NCI has $8.3 million from the Fund to support additional breast cancer research

**Notes:**
Insight grants:  a new initiative designed to support innovative pilot studies that would generate new understanding of breast cancer. It was designed to encourage investigators to explore new research areas they may not have previously published or generated preliminary data.

In FY 2004, 10 awards totaling $3.5 million were funded through provisions from the breast cancer stamp, and in FY 2005, 7 awards totaling $4.4 million were funded.

## NCI Breast Pre-Malignancy Program

- Breast pre-malignancy research was identified as the target area for use of new Breast Cancer Stamp Act funds
- The NCI Breast Pre-Malignancy Program was established, consisting of 6 research components
- A Trans-NCI Steering Committee was formed to provide oversight and integration to the Program
- All 5 extramural and both intramural Divisions and most Centers are represented

## Biology of Breast Pre-Malignancy (DCB)
Molecular Epidemiology and Mammographic Density (DCEG)
Evaluation of Decision-Making Approaches Used by Women Recruited to Chemoprevention Trials for Breast Cancer (DCP)
Evaluation Strategies to Improve Accuracy of Mammography Interpretation with the Breast Cancer Surveillance Consortium Research Resources (DCCPS)
MRI-Guided Therapy with Targeted SPIO Carbon Nanostructure --Supplement to a Breast Cancer SPORE (DCTD)
Isolation, Propagation, Characterization, and Imaging of Breast Cancer Stem Cells to Improve Early Diagnosis and Therapy of Breast Cancer; and Development and Characterization of Affibody®-Based Bioconjugates for Molecular Imaging and Targeted Therapy of HER2-Positive Breast Cancers (CCR) 

- Molecular Epidemiology and Mammographic Density (DCEG)
- Evaluation of Decision-Making Approaches Used by Women Recruited to Chemoprevention Trials for Breast Cancer (DCP)
- Evaluation Strategies to Improve Accuracy of Mammography Interpretation with the Breast Cancer Surveillance Consortium Research Resources (DCCPS)
- MRI-Guided Therapy with Targeted SPIO Carbon Nanostructure --Supplement to a Breast Cancer SPORE (DCTD)
- Isolation, Propagation, Characterization, and Imaging of Breast Cancer Stem Cells to Improve Early Diagnosis and Therapy of Breast Cancer; and Development and Characterization of Affibody®-Based Bioconjugates for Molecular Imaging and Targeted Therapy of HER2-Positive Breast Cancers (CCR)

**NCI Breast Pre-Malignancy Program**

- Six Projects were Selected by the NCI Executive Committee For Support:

## CCR Breast Pre-Malignancy Projects

- Isolation, Propagation, Characterization, and Imaging of Breast Cancer Stem Cells to Improve Early Diagnosis and Therapy of Breast Cancer
- Barbara K. Vonderhaar, Ph.D.
- Chief, Mammary Biology and Tumorigenesis Laboratory
- Co-Chair Breast and Gynecologic Malignancies Faculty
- Center for Cancer Research, NCI