# Presentation: 375951

## Advancing Emulsion Product Performance 

**July 28, 2005**

**Laura Silva**
**Anna Lee Tonkovich**
**Dongming Qiu**
**Krissy Pagnotto**
**Paul Neagle**
**Bin Yang**
**Sean Fitzgerald**
**Steven Perry**
**Jan Lerou**
**Michael LaMont**
**Jennifer Freeman**
_**Velocys, Inc.**_**, Plain City, Ohio, USA**
**     **** **

## Overview

**Overview**

** ****Velocys Technology**
-  Enabling a new process environment
** **
** ****Application to Emulsions**
-  Creating a product advantage
** ****Example: Hand Lotion  **
- Tailoring properties
** **
**Summary**

## Velocys Introduction

**Formed in 2001 as a spin-out from Battelle Memorial Institute**
**Commercializing technology developed at Pacific Northwest National Laboratory in ****mid-1990s**
**Over $70 million invested to date**
**Established alliances with partners:**
** ****chemical producers**
** ****engineering and construction**
** ****equipment manufacturing**

**Integrated Steam Reformer for Hydrogen Production**

## Conventional Reactors

**Conventional** **Technology**

**Conventional Reactors**

- Steam Methane Reformer
- 20 million standard cubic feet/day
- ~30m x ~30m x ~30m

## Velocys® Technology Reactors

**Velocys****®**** Technology ****Reactors**

- Microchannel Steam Methane Reformer
- Same capacity
- 90% volume reduction
- ~25% reduction in overall plant costs

## Technology Review

**Microchannel**
** ****vs**
**Conventional Process Technology**

**Conventional**

***Characteristic dimension***

**Technology Review**

**Velocys**

## Velocys Minimizes Time to Commercialization 

- Reduced distance for mass and energy transport
- >Surface/Volume

**Numbering up**

**Scale up**

-    Velocys critical  dimensions  remain  constant

**Scalable process**
- Velocys designs and builds massively parallel systems
- Expertise and intellectual property for flow distribution, manifolding and fabrication
- Opportunity for rapid screening formulation development, with uniform parallel processing of multiple formulations.

##  Application to Emulsions

** ****High shear at wall, lower shear in bulk**
** ****Small droplet sizes, uniform distribution**
** ****Rapid, in-line heating & cooling**
** ****Overcome scale-up challenges**
** ****Small, compact units**

## Integrated Heating & Cooling

**Gentle Heating**
- Small gradient from channel wall
- Maintains ingredient integrity
- Time at temperature minimized

**Rapid Cooling**
- Preserves emulsion properties
- Enhances stability
- Enables formula optimization

**Emulsification**

**Integrated Heating & Cooling**

## Technology Benchmarks

| Technology | Impeller | Rotor/Stator | Velocys-wall | Velocys-bulk |
| --- | --- | --- | --- | --- |
| Shear rate range, 1/s | 10 -1,000   | 20,000- 100,000  | 10,000-120,000+ | 0-5,000 |

*u**i*

****

- y

*u**i*

****

- y

**Notes:**
Microchannel benefits
Larger shear forces on the surface create a smaller and more controllable droplet size for the same mean velocity
Higher packing density of emulsion per pass and per unit surface area than in larger systems

## A Few Example Process Benefits 

** ****Prevent over-shearing emulsion constituents**
- Improve product formulation
- Incorporate shear-sensitive ingredients
** ****Reduce expensive surfactants**
- Tailor amount added
** ****Use precise control of process conditions**
- Improve consistency of product
- Exploit phase boundaries

## Example:  Hand Lotion

- Velocys particle size distribution can be controlled by changing process and equipment parameters.

- conventional
- batch mixer

- Velocys tailors
- the process

## Hand Lotion Formulation

_**Parts by (Wt.%)**_
_**First Liquid Continuous Phase, Aqueous**_
**Water****	****	****	****83.0**
**Carbopol 934****	****	****    .20**
**Na2 EDTA****	****	****  ****	****  0.05**
**Glycerine USP****	****	****  4.0**

_**Discontinuous Phase, Oil**_
**Stearic Acid****	****	****     2.00**
**Cetyl Alcohol****	****	****     0.50**
**Glyceryl Monostearate****	****     0.20**
**Ethylene Glycol Monostearate****	****     0.30**
**Propylparaben****	****	****     0.10**
**Methylparaben****	****	****     0.20**
**Mineral Oil****	****	****     7.00**
**Silicone Fluid DC200****	****	****     1.00**
**Tween 20****	****	****	****     0.50**
**Triethanolamine****	****	****     0.90**

## Tailoring Process Conditions

## Tailoring Process Conditions, continued

## In summary, Velocys emulsion technology can

**In summary, Velocys emulsion technology can**

**Enable new products / improve product performance**
- Use novel process environment to achieve new results
** ****Provide tight control of process conditions**
- Exploit possibilities with phase diagrams
- Standardize process technology
**Reduce time to deployment**
- Scale-up by numbering up channels
**Decrease production cost **
- Compact equipment
- Integrate unit operations
- Apply localized energy
- Enable distributed production

## Velocys Contact Information

**Velocys Contact Information**

**Laura Silva**
**Manager, Business Development**
**Velocys, Inc.**
**7950 Corporate Blvd.**
**Plain City, OH 43064**
**614-733-3300**
_**[silva@velocys.com](mailto:silva@velocys.com)**_
**www.velocys.com**