BEE-spoke-data/govdocs1-by-extension huggingface dataset:
# Presentation: 063657

## Direct-to-Consumer Advertising of Prescription Drugs:Current Issues

- Kathryn J. Aikin,  Ph.D.
- Division of Drug Marketing, Advertising
- and Communications, FDA
- Marketing Pharmaceuticals in a Time of Change
- February 23, 2006

## Talk Outline

- Major influences in 2005
- The year in DTC
- What is next?

## Requirements for Ads

- Per FDA regulations issued in late 1960’s, ads:
- Must not be false or misleading
- Must present “fair balance” between benefits and risk information
- Must disclose “material” facts in light of claims made about product

## What Does this Mean?

- Accurately communicate indication(s) including context for any claim
- Limitations on indication(s)
- Relevant patient population
- Concomitant therapies/treatments
- Likelihood of benefit(s)
- Communicate most important risks in a manner reasonably comparable to benefits (presentation and language)
- Cannot omit important information
- In plain language  Ads must communicate an accurate and balanced picture of the drug product

## What Events Shaped 2005?

- Reexamination of DTC advertising
- PhRMA DTC Guidelines

## Calls for Limitations on DTC Ads

- Congress
- Some companies enact voluntary delay

## PhRMA DTC Guidelines

- Follow the existing regulations
- More disease awareness
- No broadcast reminders
- Voluntary pre-submission to DDMAC
- Physician education pre-DTC

## 2005 Ads

## The Doctor

## Slide 11

## The Actor

## Slide 13

## The Conversation

## Slide 15

## Comparable Presentation of Risk and Benefit Information

## What is Next?

## Disease Awareness Advertising

## Slide 19

## Slide 20

## Where to Find Recent Guidances

- Consumer-Directed Broadcast Ads:
- http:// www.fda.gov/cder/guidance/1804fnl.htm
- “Help-Seeking” and Other Disease Awareness Communications:
- http://www.fda.gov/cder/guidance/6019dft.pdf
- Brief Summary: Disclosing Risk Information in Consumer-Directed Print Ads:
- http://www.fda.gov/cder/guidance/5669dft.pdf

## Other Online FDA Resources

- General FDA information:
- http://www.fda.gov
- DDMAC home page:
- http://www.fda.gov/cder/ddmac.htm
- Untitled and Warning Letters:
- _[http://www.fda.gov/cder/warn/index.htm](http://www.fda.gov/cder/warn/index.htm)_
- Contact info:  _[kathryn.aikin@fda.hhs.gov](mailto:kathryn.aikin@fda.hhs.gov)_
# Presentation: 379427

## Future Plans(Key Establishment Schemes)

- Address comments
- Define security attributes
- Key transport schemes
- Key wrapping
- Deriving keys from a master key
- Determine additional material
- Prepare another document
- Create draft standard/recommendation

**Notes:**
Address comments from the workshop and received via email, 
     etc.
Define the security attributes of each scheme and provide
     guidance on how to get the maximum level of security on
     given scheme (e.g., by incorporation in a secure protocol)
Address and include key transport schemes
Include a key wrapping method
Address deriving keys from a master key
Address what additional material needs to be provided in the
      appendices or in the Key Management Guideline
Prepare another document for review in about a year
Create a draft standard/recommendation

## Key Management Guideline

## Key Management Guideline

- Document developers: Elaine Barker, Curt Barker, Bill Burr, Tim Polk, Miles Smid
- Goals and Purpose
- General key management information
- Provide “best practices”
- Guidance on algorithm and key size selection
- Configuration and use guidance
- Support the key schemes document

**Notes:**
The developers for the Key Mgmt. Guideline 
workshop document are:

The general purpose of the document is to provide:
# Presentation: 245698

## Navigating the Translational Researcher Through a Complex of Animal and Biological Resources

**	**
**Natcher Conference Center**
**Bethesda, MD**
**March 6-7, 2006**
**Sponsored by the Divisions of **
**Comparative Medicine and Biotechnology**
**Workshop Report**

## Optimizing Disease Models for the Translational Researcher

- Information that is not readily accessible is of limited value.
- Disease models are many and complex.
- Naturally occurring, induced, and genetically engineered
- How does the translational scientist tap the available information to help convert interesting ideas into life-saving therapies?
- The charge of this workshop was:
- Begin to dissect this large and growing problem into smaller workable pieces.
-                                          and
- Identify a prototypic effort to begin the long journey to a resource essential for translational science

## Accessing Animal Models

- Level 1:
**E**xisting **R**esources

- Current user

- Present

- ?

**Alzheimer’s**

- Worm              Rat          Mouse      Primate          Pig             Fly

** **

## Optimizing Disease Models for the Translational Researcher

- Disease models are many and complex.
- Naturally occurring, induced, and genetically engineered
- Information not readily accessible is of limited value.
- How does the translational scientist tap the available information to help convert interesting ideas into life-saving therapies?
- The charge of this workshop was:
- Begin to dissect this large and growing problem into smaller workable pieces.
-                                          and
- Identify a prototypic effort to serve as the genesis of a resource that is essential for effective translational science

**NCRR**

##                    Accessing Animal Models

- Level 1:
**E**xisting **R**esources

-                    Accessing Animal Models

**Alzheimer’s**

- Worm              Rat          Mouse      Primate          Pig             Fly

- Present

- Future

## Recommended Next Steps

- Launch the effort from a disease category or specific disease: panel of experts to refine strategy
- Choose a prototypic effort which will be scalable
- Narrow initial focus to a single, cross-cutting disease with well-defined databases
- Possible prototypes
- neurodegenerative diseases
- Alzheimer’s Disease
- Primate and mouse
- NCRR, NIA, NIMH, NINDS
- Develop a catalog of current animal model databases

## Trans-disciplinary Problems Require Trans-disciplinary Solutions

- Trans-NIH
- NCRR supports diverse resources
- An ideal launching platform
- Categorical ICs with more focused, in-depth expertise
- Trans-agency
- Disease problems are not unique to NIH
- CDC, FDA, DOD, etc.
- Public-private partnering
- Pharma and Biotech
# Presentation: 766411

## Civil Construction Issues in PD2 Linac Upgrade

- Elliott McCrory, *et al.*
- March 21, 2002

## Slide 2

## New Equipment

- Gallery

- Build this when Booster
- gets decommissioned

## Sighting Issues

- New equipment gallery cannot invade Booster shielding
- Or new Linac shielding
- Need an 805 MHz buncher cavity about every 30 meters in injection line
- Put the Klystrons as close to cavities as possible
- Will put the four new cavities fairly far down the injection line.
- Can move these up if/when there is an energy upgrade

## Size of a Side-Coupled Module

- ~ 15 inches

- ~ 24 inches

- ~ 30 inches

- ~ 30 inches

- ~ 50 inches

## Size of the Tunnel?

- 3 ft.

- 3 ft.

- 1 ft.

- 11 ft.

- 8 ft.

## With an Unknown Thing Down The Side

- 3 ft.

- 5 ft.

- 10 ft.

## Depth of Linac Upgrade Segment

- Existing Linac

- New Linac Segment

- 762’0”

- 736’0”

- 749’0”

- 722’6”

- 730’6”

- 742’0”

- 750’0”

- 8-foot berm (approx) above grade.
*Steel is three times better than dirt.*

- 19’: *Good*!

- 13’: *bad*!!

## Other Shielding Issues (M.F.)

- Low-energy end
- X-Rays from any new RFQ will require new enclosure around it
- Backscattering of neutrons must be reduced from present levels
- 400 MeV Labyrinth
- Must make the bend to the new Linac section very cleanly
- Electronic protection of transfer line
- More dirt on new Linac section enclosure!
# Presentation: 731377

## STAT-USA®

- Economics and Statistics Administration
- U.S. Department of Commerce

**Welcome to**

**Fall 2003 Federal Depository Library Conference**
***Update Session:   STAT-USA Products***

**Presented by**
**Terri Long**
**Arlington, Virginia**
**October 22, 2003**

## Our Goal

- Similar to FDLs,      STAT-USA seeks to provide innovative and instructional ways to inform and educate the general public and educational communities through various electronic services focusing on economic and trade information

## Products and Services

- STAT-USA/Internet
- USA Trade *Online*
- EuroTrade *Online*
- Syndicate USA

**www.stat-usa.org**

## New Changes to STAT-USA®/Internet TM !

## STAT-USA®/InternetTM

- Improved Left Navigator
- New Reports Added and Old Favorites Updated
- Site Search
- -

*new and improved*

**Notes:**
Please note
Updated Programs: Survey of Current Business and International Trade Library. New ones are the Iraqi reports.

## STAT-USA/Internet Site Search

## Advanced Search

## www.usatradeonline.gov

**Notes:**
Please note the two entry points to the data:
The clickable picture at the top – “SHOW ME THE TRADE DATA!”
The hyperlink at the bottom:  “Click Here To Access The Trade Data”

## New Changes to USA Trade® Online

- Improved left navigator
- Eleven year historical data now available!
- Big changes on the horizon

## USA Trade® Online Coming Soon!

**Phase I**
- Historical monthly data (36 months)
- Flexible data selection screen

**Phase II**
- Port Data
- Method of transportation
- Tariff and unit price
- Expanded import and export data

## Additional Projects

- New STAT-USA Training resource
- Redesign of STAT-USA/Internet
- Renewed commitment to providing the most relevant trade and economic information available

## Contact STAT-USA®!

_**General Info**_
- 1-800-STAT-USA, 1-800-782-8872
- 202-482-1986 statmail@esa.doc.gov

_**Consortia Info**_
- Randy Blumenschein
- 202-482-1119 randy.blumenschein@esa.doc.gov

_**Promotional/Training Info**_
- Terri Long
- 202-482-3591 terri.long@esa.doc.gov

_**Director (Acting) **_
- Dr.  Forrest B. Williams
- 202-482-3429 forrest.williams@esa.doc.gov
# Presentation: 755030

## Slide 1

**Notes:**
Dr. Susan Adams, Alabama Shad Study
Fish sampled on the Ouachita River
07/24/03

## Slide 2

**Notes:**
Dr. Susan Adams, Alabama Shad Study
Leaf River 
09/10/03

## Slide 3

**Notes:**
Dr. Susan Adams, Alabama Shad Study
Leaf River
09/10/03

## Slide 4

**Notes:**
Dr. Susan Adams, Alabama Shad Study
Amy Commens on the shock boat,  Black Creek
09/10/03

## Slide 5

**Notes:**
Dr. Susan Adams, Alabama Shad Study
B. Bowen measuring fish,  Black Creek
09/10/03

## Slide 6

**Notes:**
Dr. Susan Adams, Alabama Shad Study
B. Bowen measuring spotted gar,  Black Creek
09/10/03

## Slide 7

**Notes:**
Dr. Susan Adams, Alabama Shad Study
Paul Mickle, B. Bowen, and B. Kreiser process samples (measurement, weight, etc.), Black Creek
09/10/03

## Slide 8

**Notes:**
Dr. Susan Adams, Alabama Shad Study
Paul Mickle, B. Bowen, and B. Kreiser process samples (measurement, weight, etc.), Black Creek
09/10/03

## Slide 9

**Notes:**
Dr. Susan Adams, Alabama Shad Study
Paul Mickle, B. Bowen, and B. Kreiser process samples (measurement, weight, etc.), Black Creek
09/10/03

## Slide 10

**Notes:**
Dr. Susan Adams, Alabama Shad Study
Fish sampled on Black Creek
09/10/03

## Slide 11

**Notes:**
Dr. Susan Adams, Alabama Shad Study
Candidate #1
09/10/03

## Slide 12

**Notes:**
Dr. Susan Adams, Alabama Shad Study
Candidate #2
09/10/03

## Slide 13

**Notes:**
Dr. Susan Adams, Alabama Shad Study
A. alabamae daily rings otolith BRB03-49(13)Money.jpg

## Slide 14

**Notes:**
Dr. Susan Adams, Alabama Shad Study
Adult A. alabamae sampled on the west branch of the Pascagoula
03/08/04

## Slide 15

**Notes:**
Dr. Susan Adams, Alabama Shad Study
Adult A. alabamae sampled on the west branch of the Pascagoula
(Photo shows the gill rakers.)
03/08/04

## Slide 16

**Notes:**
Dr. Susan Adams, Alabama Shad Study
Susan Adams holding Archosargus probatocephalus sampled on the west branch of the Pascagoula
03/08/04

## Slide 17

**Notes:**
Dr. Susan Adams, Alabama Shad Study
Susan Adams holding A. alabamae sampled on the west branch of the Pascagoula
03/08/04
# Presentation: 612196

## Slide 1

## What  is  a  Machine?

**Machine**

**Product**

***Output***

***Object***

***Input***

**Materials**

## What  is  a  Machine?

**TV**

**Sound**

***Output***

***Object***

***Input***

**Electricity**

***Example  -  TV***

**Signal**

**Picture**

## What  is  a  Machine?

**Simple Machine **

**Force**

***Output***

***Object***

***Input***

***Simple  Machine***

**Force**

## Forces

- What is  a  Force?
-            *Push   or   Pull*
- What  does  it  do?
-            *Causes  Motion*
- How  do  we  describe  it?
*          **Size  (magnitude)  *
*          **Direction*

## Why do we use simple  machines?

- To  make  life  easier!
- Simple  Machines  change  forces:
-           change the direction
-           change the size
-           change  both

## What  are the  6  simple machines?

**Inclined Plane**
**        ****Wedge**
**        ****Screw**
**Lever**
**Wheel and Axle**
**        ****Pulley**
**       **

## How  do  simple  machines  work?

-                      Conserve  Energy
-             Applied                      Resultant
-     Force  x  Distance  =  Force  x  Distance
-         force  x  Distance  =  Force  x   Distance

## Incline  Plane

**                     ****Change  Force  Direction**
**                        ****Change  Force  Size**

## Wedge

**                                          ****Change  Force  Direction**
**                                            ****Change  Force  Size**

## Screw

**                                          ****Change  Force  Direction**
**                                             ****Change  Force  Size**

## Lever

**                                          ****Change  Force  Direction**
**                                             ****Change  Force  Size**
-             Resulting  Force X Distance =  Applied Force  X  Distance

## Wheel  and  Axle

**                            ****Same  Direction**
**                       ****Change  Force  Size**
- Resultant Force  X Wheel Radius = Applied  Force X Axle  Radius

## Gears

**                    ****Change  Force  Direction**
**                       ****Change  Force  Size**

## Pulley

-                           **Change  Force  Direction**
**                         ****Same  Force  Size**

## Scavenger  HuntFind the Simple  Machines

## In  Your  Classroom

## Slide 18

## Slide 19

## Slide 20

## SRB’s Are Recovered after Splashdown

## Slide 22

## Slide 23

## Slide 24

## Hubble!

## Slide 26

## Slide 27

## Slide 28

## Slide 29

## Slide 30

## Slide 31

## Slide 32

## Slide 33
# Presentation: 142961

## Colonies of ANTS supporting the advanced habitation and development of space MC34-55

**DISTRIBUTED SPACE SYSTEM**

**Near-term Application**

**Colonies of ANTS supporting the advanced habitation and development of space **MC34-55
**Dr. Michael L. Rilee****1****, Dr. Steven A. Curtis****2****, Dr. Pamela E. Clark****1****, Dr. Cynthia Y. Cheung****2****, Walter F. Truszkowski****2**
**1****L-3 Communications GSI; ****2****NASA Goddard Space Flight Center**

**Advanced Application**

**End-to-End Architecture**

**NANO-TECHNOLOGY**

**SWARM**
_**Division of Labor**_

- _Slide 9_

- _Slide 9_

- _Slide 8_

## Slide 2
# Presentation: 567465

## Slide 1

## Slide 2

## CAQIMS Components:

**CAQIMS Components:**
**	****Climate, Air Quality and Impact Modeling System**

**CIM**

- Economic, Societal, Environmental
- Decision Making
- Support System

- HYM: Hydrology

- AQM: Air Quality

*Public health*
*Emission control*
*Energy management*

*Crop yield*
*Flood control*
*Water management*
*Ecosystem impact*

**GCM:  General Circulation Model**
**RCM:  Regional Climate Model (CWRF)**
**LPM:  Local Process Model**

**CIM:  Climate Impact Model**
**AQM:  Air Quality Model**
**HYM:  Hydrology Model**

## Figure shows precipitation information for May 2003, from observations, CWRF and MM5 simulations.  Clearly the CWRF captured the major characteristics of the observed heavy rainfall in the central eastern area, while MM5 did not.  It indicates more credibility of underlying physics and dynamics in the CWRF model.  Note that global scale circulation information is passed to the CWRF at its lateral boundaries. 

**Figure shows precipitation information for May 2003, from observations, CWRF and MM5 simulations.  Clearly the CWRF captured the major characteristics of the observed heavy rainfall in the central eastern area, while MM5 did not.  It indicates more credibility of underlying physics and dynamics in the CWRF model.  Note that global scale circulation information is passed to the CWRF at its lateral boundaries. **

## Global

**Global**

**Obs**

**MM5**

**CWRF**

## A Prototype for NOAA-wide Planning and Operational Development on Weather-Climate Connection

***NOAA In-house ***
***Capability of Weather-Climate ***
***Connection ***
_***Operational Development***_

**NWS/OST**
**Lead**

***A Prototype for NOAA-wide Planning and Operational Development on ******Weather-Climate****** Connection***

**OAR Climate Program**

**NWS S&T Infusion**

**prediction**

**assessment**

**Congressional **
**& Public**
**Inquiry**

**CWRF ****~ ****Climate Extension of Weather Research Forecasting Model**

***CWRF ***
_***Research***_
_***Collaboration***_

**ISWS/UIUC**
**OAR/ARL**
# Presentation: 066577

## Cadet Protection Program(CPPT)

## Educational Goal

- To understand the workings and importance of the Cadet Protection Program to the individual cadet.
- Each student will be able to:
- State the purpose of the CPP.
- Discuss the application of the CPP in terms of his/her experience.
- Explain the importance of the CPP in terms of training experience, and in terms of personal integrity.

## Reasonable Expectations

- Safe Environment
- Reasonable comfort and welfare
- Drug free
- Free from:
- Discrimination
- Harassment
- Sexual, Physical, and Emotional Abuse
- You don’t have to “take it”...just say no!

## Purpose

- The purpose of the CPP is threefold
- Protect cadets – minors in our care
- Protect senior members and older cadet NCO’s and officers
- Protect CAP, Inc.

## Components

- Background Screening
- All Senior Members
- All Cadet Sponsor Members (CSM)
- Report abuse to
- Trusted Senior Member or adult
- Squadron Commander
- Next higher commander
- Nation Headquarters – Corporate Legal Counsel

## CAP Policy

- Commanders should:
- Carefully select senior members in the squadron
- Encourage members to report any abuse
- When abuse is suspected:
- Suspend the member from working with cadets
- Immediately notify HQ
- Take other appropriate actions
- Conduct periodic orientation of senior members
- Insure cadets are informed of policies

## CAP Policy

- Insure at least two senior members or CSM are present at all activities
- Particularly overnight activities
- There are reasonable exceptions:
- Chaplain counseling
- O-flights

## CAP Policy

- Sexual Abuse
- Cadets are not subject to:
- Molestation
- Touching or contact
- Remarks, jokes, or stories of a sexual nature
- Any sexual material
- Physical Abuse
- Cadets will not be struck, hit, hazed or assaulted in any way.

## CAP Policy

- Procedures
- Complete fingerprint card
- Complete FBI background check
- No felony convictions
- No convictions on abuse or child-related
- Review and approval by HQ

## CAP Policy

- Required training
- Senior Members must complete it as well as cadets when they turn 18
- Orientation/Familiarization
- Cadets
- Parents

## CAP Policy

- Reporting Abuse
- Who can report abuse?
- ALL members, cadet and senior member
- Parents and guardians
- YOU!
- Hazing
- “any conduct whereby someone causes another to ‘suffer or to be exposed to any activity which is cruel, abusive, humiliating, oppressive, demeaning, or harmful’”

## CAP Policy

- Hazing (continued)
- Physical Training
- CPFT is progressive
- Must be appropriate to cadet’s age and experience
- Discipline for the purpose of punishment is prohibited
- Emotional Abuse
- Intimidation, Humiliation, Inappropriate language
- Drugs and Alcohol
- Zero tolerance
- Policy Statement: CAPR 52-16

## Conclusion

- The Cadet Protection Program is designed to protect all members within CAP, and CAP as a whole.
- You *can* report abuse
- You don’t have to just “take it”...just say no

## Questions
# Presentation: 042977

## U.S. Coast Guard, 2002

**Planning**
**Meeting**
- Develop
- strategies &
- tactics to
- Accomplish
- objectives

**Implement**
**Action Plan**

**Assess progress**
- using measures
- of effectiveness

**Management**
**Meeting**
- Evaluates
- & revises
- incident
- objectives

**Operations**
**Briefing**
- Briefs the
- operational
- leaders on the
- Action Plan

**Action Plan**
**preparation**
**& approval**

**Incident Manager**
- Sets overall
- incident objectives
- & priorities

**On-going**
**situation**
**assessment**
**& information**
**processing**

**Incident is**
**recognized**
- Notifications,
- assessment,
- Immediate
- needs
- are
- addressed
# Presentation: 669240

## Pyote, TexasMarch 21, 2004

## Slide 2

## History of Flight

- No weather briefing prior to flight
- Transporting infant between hospitals
- Provided position reports to hospital dispatch
- About 35 minutes into the flight, position report, then communication lost

## History of Flight

- Approximately 1 hour later, hospital dispatch notified local authorities of possible downed helicopter
- Ground search and rescue began
- Air search and rescue delayed due to poor weather

## Weather Conditions

- Severe thunderstorms
- Wind gusts
- Brown-out conditions and reduced visibility
- Dark night, no moon

## Flight Dispatch Procedures

- No flight dispatch
- No weather information obtained prior to departure
- Hospital dispatch
- SIGMET indicated thunderstorms along flight path
- Updated weather information not provided

## Other Issues

- No flight risk evaluation
- No Terrain Awareness and Warning System

## Slide 8
# Presentation: 670511

## D0 Weekly Summary: March 31th to April 6th 

- Delivered Luminosity and operating efficiency
- Delivered 5.7pb-1
- Recorded 4.8pb-1 (85%)
- Reasonably smooth data taking
- ~5% front-end busy at ~1.1kHz Level 1 accept rate
- ~5% hardware/software failures during beam time
- ~5% “natural” pauses: begin/end store, change prescales, etc.
- Total number of events collected
- 12mln
- All events have been reconstructed on the farms

**Day of the week **

- Dmitri Denisov

## Data Taking

- Stably collecting physics data with full detector in readout
- Typical daily operating efficiency is in 85%-90% range
- No single collision hall access request from D0 over last week
- Most of the sub-systems are working reliably
- Reached efficiency operations platou
- ~85% weekly level (up to ~98% per run efficiency)
- Similar to Run I number
- Could be increased by another “few %”, but we do not consider it as high priority goal
-  Continuing commissioning of the trigger systems
- Fiber tracker trigger
- First results on efficiency/rejection obtained
- Silicon displaced vertex trigger
- Plan for this week
- Physics data taking
- No access requests

- Dmitri Denisov
# Presentation: 689068

## ResubmittingElectronic Data Reports

- 				                 **NOx SIP Call Workshop**
- 			     	                 June 10, 2004
- 				                 Martin W. Husk, EPA

## Why Resubmit? 

- You resubmit to address an error in the electronic data report (EDR) feedback.
- You resubmit to address an error identified by the electronic audit process.
- You find an issue with your data not identified in the EDR feedback or electronic audit process.

## How to Resubmit

- During the submission period
- Use SecuRemote and ETS-FTP to submit your EDR to the EPA mainframe
- Outside of the submission period
- Contact your ETS assigned analyst to let them know you need to resubmit
- Access to the EPA mainframe will be opened
- Use SecuRemote and ETS-FTP to submit your EDR to the EPA mainframe

## How to Resubmit (cont’d)

- After Year-End Compliance
- Contact your ETS assigned analyst to let them know you need to resubmit
- Email your files to your ETS assigned analyst
- The files will be processed and feedback returned by Email

## EPA Assigned Analysts

- Region 3 - Ujjval Shukla				(202) 343-9196       shukla.ujjval@epa.gov
- Region 4 - Kevin Tran					(202) 343-9074      tran.kevin@epa.gov
- Region 5							Cindy Walke   (202) 343-9194   walke.cynthia@epa.gov  Louis Nichols  (202) 343-9008  nichols.louis@epa.gov

## Points to Remember

- You may always resubmit to fix data
- When in doubt, call CAMD
- EPA Accepted Value in the EDR feedback is used for year-end compliance
- Update your passwords
# Presentation: 245114

## UPC: Unified Parallel Cupc.gwu.edu 

_**Programming Model**_
**An explicit parallel extension of ISO C following the PGAS model**

_**Execution  Model**_
**A number of threads working independently in a SPMD fashion**
- MYTHREAD from(0..to THREADS-1
**Synchronization****: **Barriers, Locks, Memory consistency

_**Compilers**_
**Platforms supported: ****HP, Cray, SGI, IBM, Sun/Solaris, x86/x86_64, Itanium, PowerPC**
**Compilers available: ****Intrepid GCC/UPC, Berkeley UPC, MTU MuPC, HP UPC, IBM UPC, Cray Programming Environment,  ...**

_**Resources**_
**Documentations, Compilers, Tutorials, Testing suites, Benchmarking Suites, Wiki**
**UPC Textbook **ISBN: 0-471-22048-5
**Consortium: ****Berkeley, GWU, MTU, UF, IDA, LBNL, Cray, HP, IBM, Intrepid, ANL, SNL, ARSC, ... **
# Presentation: 667702

## FIGURE 2. Percentage of public provider sites participating in a grantee† immunization information system--  United States and six cities §, 2005

**FIGURE 2. Percentage of public provider sites participating in a grantee****†** **immunization information system--  United States and six cities ****§****, 2005**

- No Report
- 0-33%
- 34-66%
- 67-94%
- 95-100%

- Source:  CY2005 IISAR

- †Grantees include 50 states, five cities and the District of Columbia, funded under section 317b of the Public Health Service Act.
- §Chicago, Illinois (34%-66%); District of Columbia (67%–94%); Houston, Texas (67%–94%); New York City, New York (95%–100%); Philadelphia, Pennsylvania (95%–100%); San Antonio, Texas (95%–100%).

**National Coverage: 75%**
# Presentation: 693864

## Work Plan to do list:

- a table merging work plan dates and mission clarification table
- timelines for the individual assays
- a diagram of the Endocrine Disruptor Program activities and validation process

## Inutero Lactational Assay

- Prevalidation Study
- EPA will develop a prevalidation study plan based on protocol C in the DRP
- The study plan will identify several chemicals and recommended dose levels with justification for choices made
- EPA will e-mail the study plan to the EDMVS for a 2-week review and schedule a conference call to discuss comments

## IUL Assay (cont)

- DRP
- The EDMVS will submit comments for incorporation into the final DRP
- A table listing the endpoints of interest and predicted responses to agents of known modes of action (a qualitative prediction model) will be included
- A chart comparing protocols A,B, and C will be included.

## Pubertals: To-Do List

- Recommendation on documenting choice of strain/stock

- Consider standardizing
- vehicle
- diet
- water
- dose-setting
- light cycle
- definitions and techniques
- VO and PPS, including how measurements are to be made
- training video for techniques of concern

## Multi-dose study

- Add weak thyroid chemical if possible

## Multi-chemical study

- Include small organ weights
- add/substitute chemicals as discussed

## Other studies to consider

- strain differences in onset of puberty
- strain differences in sensitivity (e.g., adding Long-Evans rats to multi-dose study)
- ... but don’t get too caught up in strain issues (see recommendation)

## Check literature for

- PND of formation of blood/testis barrier in rats

## Other items (not specific to pubertals)

- Update table of chemicals used in EDSP studies with
- ER/AR binding study chemicals
- adult male chemicals
- corrections
- Choose a core set of chemicals to include across assays
- Provide EDMVS with rationale for doses when presenting studies

## Other items (continued)

- Include systemic toxicants that are expected to be non-endocrine-active, if possible, in assays.
- Find a more humane way for sacrifice of culls, if possible
- Code chemicals in prevalidation studies if possible
# Presentation: 170017

## SPREAD THE WORD!Raising ExcitementAbout Your MRC 

- Nancy V. Burns, Coordinator
- Upper Merrimack Valley MRC
- Town of Westford, MA
- July 8, 2004

- Nancy V. Burns – Town of Westford, MA – July 8, 2004

- Volunteer Recruitment

## Spread the Word: RaisingExcitement About Your MRC

**Know Your Audience**
**Basic PR: Messages and Proof Points**
**Designing a Promotions Plan **
**Dealing with the Media**
**Guerilla Marketing: Make it Happen!**

- Nancy V. Burns – Town of Westford, MA – July 8, 2004

- Volunteer Recruitment

## Know Your Audience

- Think like your recruits!
- -  What would entice *them* to join?
- -  How to reach this* specific* group?
- The one person to convince first
- Anticipate questions (FAQ)
- Cutting through the clutter

- Nancy V. Burns – Town of Westford, MA – July 8, 2004

- Volunteer Recruitment

## Basic PR: MessagesAnd Proof Points 

**A “Message” is your main idea:**
- We need an MRC in our area.
**A “Proof Point” is the evidence:**
- Disasters can happen anytime.
- We could have used an MRC for...
**Limit number of messages (3?)**
**Be concise and clear; stay “on message”**
**Can have several proof points per message**

- Nancy V. Burns – Town of Westford, MA – July 8, 2004

- Volunteer Recruitment

## Designing a Promotions Plan

**Start with GOALS!**
**Building Alliances**
**Budgets, Schedules, and Visions**
**Structuring a Web Site**
**Posters, Brochures, and Newsletters**
**Planning a Mass Mailing**
**Conducting an Information Session**
**Consider a Video**
**Reach Out Through the Media**

- Nancy V. Burns – Town of Westford, MA – July 8, 2004

- Volunteer Recruitment

## Dealing with the Media

**General Concepts: Editors and Reporters**
- - We *need* the media! (Think 9-11)
- - Some consider this role a calling
- - Telling the truth vs. selling papers
- - They’re your friends, not your publicists
**Media Do’s and Don’ts**
- DO “roll out the red carpet”
- DO provide your main points in writing
- DON’T back down on commitments!
**Consider all channels: TV, Radio, Newspaper, Internet**

- Nancy V. Burns – Town of Westford, MA – July 8, 2004

- Volunteer Recruitment

## Guerilla Marketing

**Seek creative ways to get the word out**
- Poster campaign (Doctor’s Day)
- Involvement in affiliated efforts (WBZ)
- Leverage other programs (CERT, EMT)
- Use your RAS
**Get a good digital camera!**
**Aim for outcomes where “everybody wins”**
**Be proud of your MRC: Spread the Word!**

- Nancy V. Burns – Town of Westford, MA – July 8, 2004

- Volunteer Recruitment

## GOOD LUCK!

**Contact us if we can help:**
**	****     ****Upper Merrimack Valley MRC**
**	****	****Coordinator****	****	****Director**
- 		Nancy Burns		Sandy Collins
- 		(978)399-2549		(978)399-2531
- 		_[nburns@westford.mec.edu](mailto:nburns@westford.mec.edu)_	_[Scollins@westford.mec.edu](mailto:Scollins@westford.mec.edu)_
-                             Westford Board of Health
-                                         55 Main Street
-                                     Westford, MA 01886

- Nancy V. Burns – Town of Westford, MA – July 8, 2004

- Volunteer Recruitment
# Presentation: 850836

## NOAA XML Standards

- NOAA Webshop
- Robert Bunge
- NWS/OCIO
- July 28, 2004

## Outline

- What is XML?
- NWS Experience
- Does NOAA have XML standards?
- Should we have XML standards?
- How do we get there?

## What is XML?

- Extensible Mark Up Language
- Similar to HTML, but you design it yourself
- Meant to aid in movement of data between computers
- Lowers cost of exchanging data
- Has been widely accepted in the private sector

## NWS Experience

- NWS averages 5-10 requests a week for XML data feeds
- First Experimental XML feed (warnings) released a year ago
- Two additional experimental feeds (forecasts/observations) released last month
- Several hundred positive public comments
- Lowers cost to put weather data into a product or electronic device
- Improves accuracy

## Does NOAA Have XML Standards?

- NWS has “XML vision” team to explore where NWS should go
- Any other LO activities?

## Should NOAA Have XML Standards?

- Appears to make sense for some data sets:
- <lat>xx.xxx</lat>
- Or
- <latitude>xx.xxx</latitude>
- Or does it matter in an age of XML schemas?

## How Do We Get There?

## Contact Info

- Bob Bunge
- NWS OCIO
- 301-713-1381 x140
- Robert.bunge@noaa.gov
# Presentation: 175682

## National Vaccine Advisory Committee

**Jerome Donlon, MD, PhD**
**June 2, 2004**

## Strategic National Stockpile

**Wyeth DryVax (1:1) Licensed****	****   8M**
**Aventis Pasteur (1:5)  IND****	****	****425M**
**ACAM2000 (1:1)****	****IND****	****	****	**_**170M**_
**	****	****	****	****	****	****	****	****503M**
**VIG  (treatments)****	****	****	****     27,400**

## ACAM2000  Phase 3 Trial

**Naïve subjects****	****	****	****1163**
**Previous vax subjects****	****	****1792**
**6 possible myocarditis cases  (5M, 1F)**
**	****	****4 asymptomatic/subclinical**
**	****	****all in naïve study **
**Clinical hold April 6, 2004 **
**	****DSMB review,  CBER review**
# Presentation: 674398

## BER Funding Profile(dollars in thousands)

- Biological and 							  FY 2002		      FY 2003
- Environmental Research			 	Conference		    President’s
- 															      _Request_
- Life Sciences							 192,573			210,878
- Climate Change Research				 128,922			137,959
- Environmental Remediation				 114,401  			109,530
- Medical Applications and                                                                  Measurement Science  				 122,999			  45,848
- Subtotal, BER							 558,895			504,215
- Construction						          11,405			           0
- _           _
- TOTAL, BER							 570,300			504,215
- 	**	**

## BER FY 2003 President’s Request 

***Life Sciences  ***

**Structural Biology****	****	****	****	****  27,847**
**Molecular and Cellular Biology****	****	****  73,264**
**	**Genomes to Life			 (36,675)
- 	Low Dose Research		 (17,523)
**Human Genome****	****	****	****	****  90,185**
**Health Effects****	****	****	****	****  14,251**
**SBIR/STTR****	****	****	****	****	****    5,331**
**TOTAL****	****	****	****	****	****210,878****	**

## BER FY 2003	  President’s	Request 	Climate Change Research     

- 						_**FY 2003**_
**Climate and Hydrology**				  **74,669**
- Climate Modeling				  27,181
- ARM					  44,751
- UAV				 	    2,737
**Atmospheric Chemistry and Carbon Cycle****	****	****  37,764**
- Atmospheric Science				  12,571
- Terrestrial Carbon Processes			  13,716
- Ocean Sciences				    2,920
- Carbon Sequestration Research			    8,557
**Ecological Processes****	****	****	****	****  13,888**
**Human Interaction****	****	****	****	**** ****	****    8,084**
**SBIR/STTR****	****	****	****	****	****    3,554**
**TOTAL****	****	****	****	****	****	****137,959****	****	****	****	****	****	****	**

## BER FY 2003 President’s Request

***Environmental Remediation ***

**Bioremediation Research****	****	****30,700**
**    ****(incl. GPP and GPE)**
**Clean Up Research****	****	****	****38,190***
**Facilities Operations (EMSL)****	****	****37,948   **
**SBIR/STTR****	****	****	****	****   ****	****  2,692**
**TOTAL****	****	****	****	****         109,530**
***Includes EMSP ($29,886,000) and Savannah River Ecology Lab ($5,841,000)**

## BER FY 2003 President’s Request

***Medical Applications and Measurement Science***

**Medical Applications****	****	****	****	**** 38,701**
**	**Radiopharmaceutical Design
- 	    and Synthesis			(24,445)
- 	Multimodel Imaging Systems
- 	    and Medical Photonics		  (9,386)
- 	Novel Cell Directed Therapies		  (4,870)
- 	Congressional Direction			  (       0)
**Measurement Science****	****	****	****	****     5,961**
**SBIR/STTR****	****	****	****	****  ****	****     1,186**
**TOTAL****	****	****	****	****	****	****   45,848**
# Presentation: 514492

## Schedule

- A word about alignment plans	- Prebys
- A first look at vertical data – Lackey
- 400 MeV line status – Garcia
- When do we move the collimator? – Prebys
- AOB, study requests, etc.

## Alignment in the Booster

- Always been recognized as a problem
- A little over a year ago, we started a vertical network of the entire Booster
- Level run
- 4 survey points on each magnet (some a bit complicated)
- (Mostly) completed during the shutdown.  Data now in hand.
- Some big problems (Lackey will discuss).
- Historical difficulties
- Lack of priority!
- Lack of a coherent plan, both on our part and alignment.
- Inefficient use of downtime (response time issues).
- Solution?  What else – a task force.

## The Plan

- Peter Kasper put in charge of coordinating alignment on our end.
- O’sheg made task manager on the AMG end.
- Andrew Feld will be trained as a liaison.
- Near term goals (ASAP as opportunities arise)
- Complete vertical network (5-10% to be done or redone)
- Develop a plan for vertical moves, including both “opportunities” and longer term requests.
- Align RF cavities and other key elements to optical center of straights.
- Longer term (aim to complete by next big shutdown)
- Produce a “beam sheet” based on Sasha’s MAD file
- Add non-magnetic elements
- Complete network, including horizontal.

## Some key issues

- Decide what moves make sense on short accesses, and what will require longer downtime.
- Does it make sense to move a magenet twice?
- Priority:
- I’m trying to convince Roger that the Booster should always have priority for one crew *no matter what else is going on.*
- Efficient use of unscheduled downtime
- A big problem in the past.
- Need to develop a well-defined to-do list, so alignment can respond quickly if there’s an opportunity.

## Collimators

- Chose to wait until we were running “better than when we shutdown”.
- This happened last week, so we were going to start this week.
- This week
- Efficiency has dropped.
- Dave has asked us to wait to finish the 400 MeV line studies.
- I’d like to start next week.
- I’m working up a study plan.
- I’ll be gone Monday and Tuesday.
- I would like to start studies late next week.
# Presentation: 951357

## OGSA-DAI DQPA very brief introduction

- Scott Oster
- Ohio State University

## Overview

- OGSA-DAI components are either data access components or data integration components. A *Distributed Query Processing* (DQP) system is an example of a data integration component and can potentially provide effective declarative support for service orchestration as well as data integration. The service-based DQP framework described in provides an approach that:
- supports queries over GDSs and over other services available on the Grid, thereby combining data access with analysis;
- uses the facilities of the OGSA to dynamically obtain the resources necessary for efficient evaluation of a distributed query;
- adapts techniques from parallel databases to provide implicit parallelism for complex data-intensive requests; and
- uses the emerging standard for GDSs to provide consistent access to database metadata and to interact with databases on the Grid.

## Layers

## Non-Distributed Query in OGSA-DAI

## DQP Services

- The service-based DQP framework extends the OGSA-DAI with two new services (and their corresponding factories):
**Grid Distributed Query Service (GDQS).**
- main interaction point for the clients.
- interacts with the appropriate registries to obtain the metadata and computational resource information that it needs to compile, optimise, partition and schedule distributed query execution plans over multiple execution nodes in the Grid.
- implementation of the GDQS builds on a previous work on the Polar* distributed query processor for the Grid by encapsulating its compilation and optimisation functionality.
**Grid Query Evaluation Service (GQES).**
- created by the GDQS based on the query plans generated by the query compiler, optimiser and scheduler.
- each GQES instance evaluates a partition of the query execution plan assigned to it by a GDQS.
- the set of GQES instances form a tree through which the data flows from leaf GQESs which interact with GDSs, up the tree to reach its destination.
- As well as using the services provided by *Grid Data Services* (GDSs), the GDQS and GQES both implement GDS port type, and thus can be discovered and invoked in the same way as other GDSs.

## DQP Interactions

## For More Information

- _[http://www.ogsadai.org.uk/dqp/](http://www.ogsadai.org.uk/dqp/)_
- _[http://www.ogsadai.org.uk/docs/OtherDocs/DBGS.pdf](http://www.ogsadai.org.uk/docs/OtherDocs/DBGS.pdf)_
- http://www.ogsadai.org.uk/docs/OtherDocs/DQP-AllHands2003.pdf
- http://www.ogsadai.org.uk/docs/OtherDocs/114.pdf
- http://www.ogsadai.org.uk/docs/OtherDocs/SB-DQP-NESCWorkshop-30-06.pdf
- http://www.nesc.ac.uk/talks/273/Galt03_Fernandes.ppt
# Presentation: 839814

## Compact Near-Infrared Spectrometer

**Compact Near-Infrared Spectrometer**

**S**mall
**B**usiness
**I**nnovation
**R**esearch

**Brimrose Corporation Of America**

- Baltimore, MD

**INNOVATION**
- Compact, low power, rugged, high resolution
- near-infrared spectrometer
**                  ****ACCOMPLISHMENTS**
- Produced first miniaturized, rugged, high-performance near-infrared spectrometer
- Demonstrated the use of a clocked led as illuminating source
-                **COMMERCIALIZATION**
- Near infrared spectrometers are finding applications in a number of industries for process control
- Industries presently using technology include petroleum and petrochemicals, pharmaceuticals,  food processing and pulp and paper.
- Sales exceed $7 million a year

**GOVERNMENT/ SCIENCE APPLICATIONS**
- Potential sensor instrument for future NASA science mission

***Technology Found Wide Commercial Application***

- Jet Propulsion Laboratory
- Success Story #7-007

- 1992 Phase II; NAS7-1296
- NASA/JPL - Joy Crisp
- Company Contact - Sean Wang
# Presentation: 304135

## Slide 1

## Figure 6-1.  Schematic of the Twin Butte tailings disposal area.

**Figure 6-1.  **Schematic of the Twin Butte tailings disposal area.

## Slide 3

## Figure 6-2.  Geochemical fingerprint pattern for Twin Butte tailings leachate.

**Figure 6-2.  **Geochemical fingerprint pattern for Twin Butte tailings leachate.

## Figure 6-3.  Trace metal fingerprint pattern for Twin Butte tailings leachate.

**Figure 6-3.**  Trace metal fingerprint pattern for Twin Butte tailings leachate.

## Geochemical Parameters

- Trace Metals

## Slide 7

## Figure 6-6.  Trace metal fingerprint patterns in Twin Butte column eluant samples.

- Fingerprint Match

**Figure 6-6.**  Trace metal fingerprint patterns in Twin Butte column eluant samples.

## Fingerprint Match, %Figure 6-7.  Tailings leachate composition over time at Twin Butte Tailings Pond 3.

- Fingerprint Match, %**Figure 6-7.**  Tailings leachate composition over time at Twin Butte Tailings Pond 3.

## Figure 6-8.  Geochemical fingerprint pattern in Twin Butte Tailings Pond 3.

**Figure 6-8.**  Geochemical fingerprint pattern in Twin Butte Tailings Pond 3.

## Figure 6-9.  Trace metal fingerprint pattern in Twin Butte Tailings Pond 3.

**Figure 6-9**.  Trace metal fingerprint pattern in Twin Butte Tailings Pond 3.

## Figure 6-10.  Geochemical fingerprint at upgradient Well M-3.

**Figure 6-10**.  Geochemical fingerprint at upgradient Well M-3.

## Figure 6-11.  Trace metal distribution at upgradient Well M-3.

**Figure 6-11.**  Trace metal distribution at upgradient Well M-3.

## Figure 6-12.  Geochemical fingerprint at downgradient Well M-1.

**Figure 6-12.**  Geochemical fingerprint at downgradient Well M-1.

## Figure 6-13.  Trace metal distribution at downgradient Well M-1.

## Figure 6-14.  Geochemical fingerprint pattern at Well M-2.

## Figure 6-15.  Area plot of monitoring results at Well M-2.

**Figure 6-15.**  Area plot of monitoring results at Well M-2.

- Fingerprint Match, %

## Figure 6-16.  Monitoring results from downgradient Well 1225.

**Figure 6-16.**  Monitoring results from downgradient Well 1225.

- Fingerprint Match, %

## Figure 6-17.  Monitoring results from downgradient Well M-7.

**Figure 6-17.**  Monitoring results from downgradient Well M-7.

- Fingerprint Analysis, Well M-7

- Fingerprint Match, %

## Figure 6-18.  Monitoring results from downgradient Well M-5.

- 0                           20                           40                           60                           80                          100

**Figure 6-18.**  Monitoring results from downgradient Well M-5.

- Fingerprint Match, %

## 	Figure 6-19.  Monitoring results from downgradient Well 1758.

- 	**Figure 6-19.**  Monitoring results from downgradient Well 1758.

- Fingerprint Match, %

- 0                           20                           40                           60                           80                          100
# Presentation: 400208

## Reducing GHGs from Mobile Sources at the State Level

- 2008 National Air Quality Conference
- Jeffrey Ang-Olson
- April 8, 2008

## Introduction – State Climate Action Plans

- Why state level approach is important
- Can have large impacts – 34 of 75 largest GHG sources in the world are U.S. states
- States are testing grounds for emerging policy
- State actions can build political support at federal level
- This presentation reviews experience in 8 states
- AZ, CO, MN, MT, NC, NM, VT, WA

## GHGs and Transportation Sector

- After electricity generation, transportation is leading source of U.S. GHG emissions
- Transportation sector accounts for 28% of GHGs nationally – much higher in some states

## U.S. Transportation GHG Emissions by Source, 2005

## Approach to Plan Development

- Center for Climate Strategies (CCS) has helped many states develop their plans
- Plans propose specific policies and programs for consideration by the state  legislature or implementation by state agency
- Stakeholder groups convened to develop policies aimed at meeting state emission goals

**36 states have developed or are developing a climate plan**

## Role of Stakeholder Groups

- Transportation is one of several key areas for policy development

## Transportation Stakeholder Groups

- Typically include 15-20 members representing:

- state departments of environment
- state departments of transportation
- state departments of energy
- MPOs
- local governments

- non-profits
- alternative fuels advocacy groups
- academia
- transportation industry groups
- other private industry

## Step-Wise Plan Process

- Step 1: Develop initial statewide GHG inventories and projections
- Step 2: Draft a catalog of possible GHG policy options
- Step 3: Identify initial draft priority policy options for evaluation
- Step 4: Develop proposals for draft policy option design
- Step 5: Quantify potential GHG reduction and cost of draft policy options
- Step 6: Define implementation mechanisms, related policies and programs, and feasibility issues
- Step 7: Iterate to final consensus on draft policy options through voting by plenary group
- Step 8: Finalize recommendations and report

## Types of Strategies Included in Plans

- GHG emissions standards for LDVs
- Smart growth measures
- Clean car purchase incentives
- Promotion of transit
- Alternative fuels

- Pay-as-you drive insurance
- Non-road measures
- Emissions reduction measures for diesel vehicles
- HDV anti-idling measures

## Frequency of Strategy Inclusion

## Strategy Effectiveness (examples)

## Looking Ahead

- At least nine other states are developing climate action plans
- States adopting selected policy recommendations
- WA per-capita VMT reduction goals
- AZ clean car GHG standards
- As states gain experience, policies and quantification methods will continue to be refined

## Questions or Comments?

- Jeffrey Ang-Olson
- _jangolson@icfi.com_
- 415-677-7110