# Presentation: 464551

## Medical Library Association

- Dallas, Texas
- May 21, 2002
- NLM Update
- Donald Lindberg, MD

## NLM Update

- 1.  Consumer health information
- 2.  Genetic medicine
- 3.  NLM grants & awards
- 4.  New building at NLM
- 5.  Terrorism & disasters

## Consumer Health Information

- MedlinePlus new features
- Better drug info
- Attention to Low Vision soon
- En Espanol pronto
- ClinicalTrials.Gov
- Adding industry sponsored trials
- Public library efforts

## Genetic Medicine

- NCBI data linkages
- Gene indexing & annotation

## Entrez is NCBI’s search & retrieval  system:
Provides access to sequence, mapping, taxonomy, and structure data
Graphic views of sequences & chromosome maps & references
BLAST - sequence similarity searching: 
15 seconds for search vs 15 M sequences and >14B base pairs from >100K species
Accessed via Web >200K/day by >50K researchers

**Provides access to sequence, mapping, taxonomy, and structure data**
**Graphic views of sequences & chromosome maps & references**
**BLAST - ****sequence**** similarity searching: **
**15 seconds for search vs 15 M sequences and >14B base pairs from >100K species**
**Accessed via Web >200K/day by >50K researchers**

**NCBI Data  Links**

## Old stuff....Where’s the new stuff?

## NCBI protein db survey

- Protein function based on experimental evidence from published literature
- Classification into protein families based on sequence similarity and function
- Identification of protein domain architecture, with links to alignments and structure
- Annotation of functional sites, processing pathways, and degradation sites based on evidence from published literature
- Features derived from computational predictions

- 1,913 Respondants

## Gene Indexing:   an article from Nature Neuroscience 

- Indexers create link between article PMID and mouse Myo7a gene record in LocusLink
- Indexers add descriptive statement to mouse Myo7a gene record in LocusLink:  “*participates in anchoring and holding membrane-bound elements to the actin core of the stereocilium*”

## NLM Indexing Project

- PubMed articles attached to gene products as part of the MeSH indexing flow
- 300 articles -> 37 links = 1 link per 8 articles
- 5,524 articles -> 417 links = 1 link per 13 articles
- 535,000 articles a year => 27,000 to 53,000 links between protein and literature per year

## NLM Grants & Awards

- Protein data base - Request for Proposal
- BISTI Program
- NLM Training Grants
- IAIMS
- NN/LM new contracts
- Scalable Information Systems

## NLM, NHGRI, NIGMS, NIMH, NCRR, NIDCR
Repository of curated protein sequences
Annotated re both sequence and function
Coordinate entries & reference terminology with data bases containing complementary data, including those of NCBI
Applications due April 2002; award August 2002
USA and foreign
Cooperative agreement
Scientific Advisory Panel of national experts

**Repository of curated protein sequences**
**Annotated re both sequence and function**
**Coordinate entries & reference terminology with data bases containing complementary data, including those of NCBI**
**Applications due April 2002; award August 2002**
**USA and foreign**
**Cooperative agreement**
**Scientific Advisory Panel of national experts**

**RFP for new central Data Base of Protein Sequence & Function**

## BISTI Biomedical Information & Technology Initiative

- Columbia Univ - NLM - $700M
- Yale Univ - NLM - $400M
- Univ Utah - NHLBI - $700M
- Institute for Systems Biology - NIGMS - $700
- Rutgers Univ - NIGMS - $400M
- Stanford Univ - NIGMS - $400M

## Columbia University BISTI

- Center for Computational Biology & Bioinformatics
- Program of education & research
- Single Nucleotide Polymorphism  analysis & relationship to human disease
- Protein structure analysis
- Tile analysis of microarrays
- Functional annotation of proteins
- Study of networks of interacting proteins
- 3D structure-based design of new pharmaceuticals

## Yale University BISTI

- Biomedical Computing Center of Excellence
- Program
- Heterogeneous biomedical data base design
- e.g. for microarray experimental results
- Data mining to relate protein characteristics to gene expression

## List of Training Grant Sites

- UNIVERSITY OF CALIFORNIA LOS ANGELES		CA
- UNIVERSITY OF WISCONSIN MADISON			WI
- MEDICAL UNIVERSITY OF SOUTH CAROLINA		SC
- UNIVERSITY OF WASHINGTON				WA
- UNIVERSITY OF CALIFORNIA IRVINE			CA
- VANDERBILT UNIVERSITY				TN
- JOHNS HOPKINS UNIVERSITY				MD
- STANFORD UNIVERSITY					CA
- UNIVERSITY OF MINNESOTA TWIN CITIES			MN
- YALE UNIVERSITY					CT
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH		PA
- COLUMBIA UNIVERSITY HEALTH SCIENCES		NY
- OREGON HEALTH & SCIENCE UNIVERSITY		OR
- UNIVERSITY OF MISSOURI COLUMBIA			MO
- HARVARD UNIVERSITY (SCH OF PUBLIC HLTH)		MA
- RICE UNIVERSITY					TX
- INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS		IN
- UNIVERSITY OF UTAH					UT

## NLM IAIMS Grants

**PLANNING – 2 years - $150,000 per year**
** **
**OPERATIONS – 4 years - $400,000 per year, directs only; prerequisite written plan or testing & evaluation report**
**PILOT STUDY - 2 years – $75,000 per year **
**TESTING & EVALUATION – 2 years - $100,000 per year **
**IAIMS FELLOWSHIP –1 or 2 years - $50,000 per year plus $6,000 administrative supplement**

## NLM IAIMS Grants

**Program priorities**
**Reach beyond a single organization**
**Deliver direct information services to users, especially consumers**
**Benefits underserved rural or inner-city populations**
**Involve the library, informatics and other information groups**

## Application of Advanced Network Infrastructure Technology in Health and Disaster Management

**focus on situations that will require or greatly benefit from these technologies in health care, medical decision-making, public health, large-scale health emergencies, health education, and biomedical, clinical and health services research**
**must involve the use of testbed networks linking hospitals, clinics, health-related schools, libraries, research centers and laboratories, and/or public health authorities**

## Application of Advanced Network Infrastructure Technology in Health and Disaster Management

**demonstrate one or more of the following capabilities:  **
**1) Self-scaling applications **
**2) Self-optimizing, end-to-end network aware, real-time applications and/or middleware**
**3) Wireless applications**
**4) Nomadic application and/or applications using geographic information systems (GIS) techniques **
**5) Applications which involve advanced identification methodologies, e.g., biometrics or smartcards. **
**NLM URL:****  **_**http://www.nlm.nih.gov/oam/oam.html**_

## Third NLM Building

- Need
- Design
- Future of medical libraries

## Alison Bunting

## Need for an additional NLM Building

- 1100 people in a space designed for 600
- Four “temporary” remote locations
- No more space to store additions to the  library collections after 2004
- Architectural updating needed
- Americans with Disability Act
- Normal deterioration in some sections
- New security demands

## Crowded Library Conditions 1

## Crowded Library Conditions 2

## Design So Far

## Medicine’s Library of the 21st Century

## Slide 27

## Research Building (38B)

**Research Building (38B)**
**200,000 gsf**

**Lister Hill**
**Center (38A)**

**Visitor & Conference**
**Center 40,000 gsf**

**110,000 gsf growth**
**Existing library (38)**

## Collaboratory

**Collaboratory**

## Slide 30

## Terrorism & Disasters

- NLM is not an intelligence agency
- NLM supported research includes
- Info systems to detect epidemics
- Info systems for use in emergencies
- Info systems to support early warning & emerging bio-threats
- NIH/NLM are getting more security conscious
- Disaster management
- NLM’s security efforts
- NLM / PAHO partnership in central America

## Bio-metrics - iris  scan

## Bio-metrics - hand geometry

## NLM / PAHO in Honduras

## Cecilia Garcia

## Hurricane Mitch

## End

## Cecilia Garcia