# Presentation: 924389

## NCI Commitment to the MI/CCP Program

**NCI Commitment to the MI/CCP Program**
**2015 Challenge Goal**
** ****and **
**Cancer Health Disparities**

- November 20, 2003

**National Cancer Institute**

- U.S. Department of Health and Human Services

- National Institutes of Health

**19% ****Increase**

- Projected U.S. Cancer Prevalence

- All Sites (2000 – 2015)

- 9.5 Million

- 11.3 Million

## 51%

**51%**

**39%**

**64%**

**53%**

- 5-Year Relative Survival Rates – Trends

- By Race (1974 – 1999)

## “To eliminate the suffering and death due to cancer by 2015”

**“****To eliminate the suffering and death due to cancer by 2015”**

_***NCI Challenge Goal***_

## How Will We Do This?

**Discovery**

**Development**

**Delivery**

***Discovery****** of relevant mechanisms  ***
***Development****** of interventions for better detection, diagnosis, treatment, and prevention ***
***Delivery****** to all in need ***

**How Will We Do This?**
*New Paradigm-New Hope*

**Notes:**
So how do these incredible achievements align themselves within our overall national strategy and goals...

## NCI 2004 Strategic Priorities

**Molecular Epidemiology: New Approaches to Understanding the Causes of Cancer**
**Early Detection, Prevention, Prediction**
**Integrative Cancer Biology**
**Strategic Development of Cancer Interventions**
**Integrated Clinical Trials System**
**Overcoming Health Disparities**
**Bioinformatics**

**NCI 2004 Strategic Priorities**
**Setting Course for Accelerated Progress**

**Notes:**
Priorities set by NCI’s leadership toward Goal 2015 ...

## Accelerating Progress

**Accelerating Progress**
**1. Molecular Epidemiology**

_**GOAL**_

- Understand the behavioral, environmental, genetic, and epigenetic causes of the overwhelming majority of cancers in the human population that yield new opportunities to improve the prevention of cancers and the treatment of patients.

**Notes:**
Priorities set by NCI’s leadership toward Goal 2015 ...

## Accelerating Progress

**Accelerating Progress**
**2. Prevention, Early Detection, Prediction**

_**GOAL**_

**Notes:**
Priorities set by NCI’s leadership toward Goal 2015 ...

## Cancer Prevention Portfolio

**Cancer Prevention Portfolio**

- FY2003 NCI Prevention Budget = **$1.76 Billion**

**Behavior**
**Interventions**

**Large Population Studies**

**Behavior Modification**

**Chemoprevention Trials**

- Example:
- Tobacco Cessation Programs

**National Lung Screening Trial**
- $200 Million; 7 years
- 50,000 patients

**Risk Intervention Strategy**

- Potential Impact on ***169,400*** new lung cancer cases per year and ***154,000 ***deaths per year
***85% mortality vs. 85% survival***

**Mechanisms**
**(Addiction)**

- Example:
- 5 A Day for Better Health

- Example:
- Genetic Susceptibility Studies

- Example:
- Tamoxifen/  Raloxifene
- Selenium/ Vitamin E

**Early Detection**

- HPV vaccine

## Accelerating Progress

**Accelerating Progress**
**3. Integrative Cancer Biology**

_**GOAL**_

- Understand the complex networks within cancer cells and between cancer cells and their environment to discover new leads for cancer prevention, detection, diagnosis and/or treatment.

**Notes:**
Priorities set by NCI’s leadership toward Goal 2015 ...

## Accelerating Progress

**Accelerating Progress**
**4. Strategic Development of Cancer Interventions**

_**GOAL**_

**Notes:**
Priorities set by NCI’s leadership toward Goal 2015 ...

## Advanced Biomedical Technology

- Link technology development and biomedical research
- Create opportunities to accelerate understanding of genetic, molecular, cellular mechanisms of cancer
- Enable convergence and connection of multidisciplinary scientific, medical, physical, and mathematical expertise

***Advanced Biomedical Technology***

## Advanced Biomedical Technology

_**Strategic Collaboration**_
-  DHHS
- NIH Institutes and Centers
- Federal Agencies
**Cancer Centers**
- Academic community
- Private industry** **

***Advanced Biomedical Technology***

## Advanced Biomedical Technology

**Integrative**
**Computational**
**Biology and**
**Bioinformatics**

**Advanced**
**Imaging**

**Core**
**Research**
**Applications**
**cGMP**
**Facility**

**Bioengineering**
**and Advanced**
**Prototyping**

**Integrative**
**Enabling**
**Technologies**

**Enabling Critical Multidisciplinary Biomedical Research**

**Other**
**Federal Science**
**Agencies**

**Academic**
**Medical Centers**

**Centers of Technology**
**Excellence**

**Biotechnology and**
**Pharmaceutical**
**Industry**

**Universities**
**and Research**
**Institutes**

***Advanced Biomedical Technology***

## Accelerating Progress

**Accelerating Progress**
**5. Integrated Clinical Trials System**

_**GOAL**_

- Establish an integrated clinical trials system to accelerate intervention development and ensure that those interventions are efficiently and seamlessly incorporated into standards of care for all populations.

**Notes:**
Priorities set by NCI’s leadership toward Goal 2015 ...

## Accelerating Progress

**Accelerating Progress**
**6. Overcoming Cancer Health Disparities**

_**GOAL**_

- To overcome the burden of cancer that is borne by different populations groups within the United States.

**Notes:**
Priorities set by NCI’s leadership toward Goal 2015 ...

## A collaborative model 

**Trans-HHS Cancer Health Disparities ****Progress Review Group  (PRG)**

**A collaborative model **
**to reduce cancer-related**
** ****health disparities**

## NCI Progress Review GroupWill Address Health Disparities

**  ****Phase III: ****Reporting**
** ****Collect Progress Data**
** ****Develop Progress Report**
** ****Discuss Progress with PRG**
** ****Prepare & Promote Revised Implementation Plan**

**  ****Phase I: ****Recommendation**
** ****Leadership Meeting**
** ****Planning Meeting**
** ****Roundtable Meeting**
** ****Leadership Presents Key Report Recommendations**
**Report Released to Community**

**NCI Progress Review Group***Will Address Health Disparities*

## PRG Action Plan

**PRG Action Plan**
**Strategic  ********  Collaborative  ********  Practical  ********  Evidence-Based  ********  Measurable**

**NCI**

**NIH**

**HHS**

**The**
**Nation**

_**NIH**_
** ****NCI **** NCMHD **
** ****NIDDK **** NHLBI **
- ** ****NIMH **** NIEHS **
**NIGMS **** OBSSR**** **

_**DHHS **_
**OS **** OMH **** CDC **
**AHRQ **** CMS **** IHS **
- ** ****HRSA **** SAMHSA **

_**NATION**_
- ** ****Patients ** **Advocates **** **
**State/Local Governments**
-  **Foundations **** Academia **** **
**Physicians **** Communities**
- ** ****Health Care Systems **
**Cancer Centers**

## Cancer Disparities: Funding FY 2004

**Cancer Disparities: Funding FY 2004**

**Expand research to understand the causes**
**Develop effective interventions to reduce disparities**
**Expand ability to define and monitor disparities**
**Facilitate new policy, community and clinical interventions, and evaluate their impact**
**Expand minority investigator competition and involvement in health disparities research**
**Management and Support**

**Total**

- $16.2M

- $9.5M

- $6.0M

- $17.9M

- $9.75M

**$61.35M**

- $2.0M

## Accelerating Progress

**Accelerating Progress**
**7. Bioinformatics**

_**GOAL**_

- Develop a virtual web of interconnected data, individuals, and organizations that will redefine how research is conducted, care is provided, and patients/participants interact with the biomedical research enterprise.

**Notes:**
Priorities set by NCI’s leadership toward Goal 2015 ...

##  WHAT ? 

** ****WHAT ? **
- 	A biomedical informatics network connecting members of the NCI-designated Cancer Center Community
** ****WHY ? **
- 	Need to enable individual investigators and research teams to combine and leverage their findings
** ****HOW ?**** **
- 	Infrastructure to meet the common needs of Cancer Centers and synergize their expertise
** ****WHEN ?**** **	 NOW** **

**Notes:**
We will build the bioinformatics infrastructure to create a virtual Web linking centers, academe, government ... Data will be shared in real time.

## National Biospecimen Network (NBN)

**National Biospecimen Network (NBN)**

**Will be the largest and most comprehensive tissue resource in the country.  **
**Will collect tissue, blood, and serum, pathology data, clinical data and genetic information.**
**Will establish a standardized method of collecting tissue specimens and related data.**
**Resources will be available for research at public and private institutions throughout the country. **

**Notes:**
Ready-Fire-Steer

## Slide 24