BEE-spoke-data/govdocs1-by-extension huggingface dataset:
# Presentation: 931867

## Researchers

**Space Weather Week****—**
**A Coming Together of the Space Weather Community**

**Barbara Poppe and Terry Onsager**
- NOAA Space Environment Center

**How is the environment disturbed by **
**solar events?**

**An Example of a figure and Text**

**Approximately 140 Researchers attended Space Weather Week 2000**.
-  They were from
- US and foreign Universities
- Universities and organizations supported by the National Space Weather Program
- Government agencies (NSF, NOAA, NASA, DoD ...)
- Industries supported by DoD

**How do space environment disturbances **
**affect my systems?**

- Users

**How do we facilitate researcher-user interactions that result in relevant development?**

- SEC

**Space Weather Week features “Prediction Challenges” to find the most**
**promising research models to enhance operational space weather support.**
**Models whose value is demonstrated through the Prediction Challenges**
**become candidates for transition to operations through the SEC Rapid**
**Prototyping Center.**

- “Space Weather Week provides an essential service to the space weather community.  The National Science Foundation is extremely interested in seeing its basic research results serve society.  For space weather, that means scientists and space weather "customers" must learn about and appreciate each others needs and interests.  Space Weather Week provides exactly the right forum for this critical exchange of information and ideas.”—Dr. Richard Behnke, Head, Upper Atmosphere Research Section, National Science Foundation

**Approximately 50 Users attended Space Weather Week 2000**.
-  They were from
- Industry
- Vendor community
- News Media
- NASA, FEMA, and other 	              Government Agencies
- General Public

**Approximately 30 SEC staff attended Space Weather Week 2000**.
-  They were
- Forecasters
- Soltechs
- Outreach staff
- Support staff

**Moving Research into Operations**
# Presentation: 120623

## Electronic Standards Development

- Bringing ASTM International to the World

## Global Participation

- Made easy through use of the World Wide Web
- No travel restrictions
- No time delays
- Access to information 24 hours per day, 7 days per week, 365 days per year

## Opportunity to Participate	

- Interactive Standards Development Forums
- Electronic Balloting
- Virtual Meetings

## Interactive Standards Development Forums

- Approximately 300 currently active:
- Small number of technical experts
- Password access to a posted document
- Ability to post & review comments
- Group and/or individual email capability

## Electronic Balloting

- Scope of Activity:
- 354 ballots
- 1920 items
- 34,493 members

## Electronic Balloting

- Email notification that ballots are open
- Email reminders if no vote received
- Password access to ballot
- Ability to view & save ballot items
- Electronic submission of votes
- Electronic confirmation of receipt

## Virtual Meetings	

- Combination of telephone and Web conferencing
- Allows attendees to be connected by sight and sound

- Standards Development Forums, Electronic Balloting, and Virtual Meetings are located on the ASTM International website.
- _[http://www.astm.org](http://www.astm.org/)_
- Jim Olshefsky, Director, Committee Services: _[jolshefs@astm.org](mailto:jolshefs@astm.org)_
# Presentation: 294363

## U.S. Customs and Border Protection
July 2008

- U.S. Customs and Border Protection
- July 2008

## Welcome Page

## Welcome Page

**Welcome Page**

## Disclaimer Page

## Applicant Information

## Passport and Travel Information

## Eligibility Questions

## Waiver of Rights

## Application Review

## Application Number

## Response – Authorization Approved

## Response – Travel Not Authorized

## Response – Authorization Pending

## Welcome Page

## Update Page

## Questions?

- ESTA Program            Management Office
- (202) 344-3710
- esta@cbp.dhs.gov
- *All Screen shots are subject to change without notice.

**Questions?**
# Presentation: 265868

## Heat-Flux Measurement - Issues

-   Convection heat transfer effects (Schmidt-Boelter & Gardon)
-   Non-uniform temperature distribution on sensor (Gardon)
-   Different calibration methods by manufacturers
-   Lack of suitable traceability to National Standards

## Heat-Flux Measurement - Status

-   No major break-through in sensor manufacture
-   Calibration issues still persist  (Sarkos, Hill &
-     Johnson 1995)

## Calibration Approach - NIST

** ****Detector Based**
**(Flux)**

- Blackbody radiation

**Source Based**
**(Temperature)**

**Flux measured**
- Absorbs incident flux
- Flux traceability to National Standards

**Flux derived**
- Effective emissivity Configuration factor
- Source temperature

**Factors: Calibration range, source temperature, view angle**

**Establish equivalence**

## Resolving Calibration Issues

-   Common Interest Group – Government/Users/ Manf.
-   Evaluation of different calibration techniques
-   Standard development efforts – ASTM/ASME
-   Provide traceability to Primary Standards

- National Level

## Resolving Calibration Issues

-   Fire Laboratories Round-robin [NIST-BFRL/PL]
-   International Standards Organization
-  ISO Flux Meter calibration standard Development
-  Ellipsoidal radiometer evaluation [SP, Sweden]

- International Level

## Major Outcome of Collaboration

- Flux-scale calibration suitable when
- reflected component is large part of incident flux,
- source characteristics difficult to establish
- Temperature & flux scales equivalence demonstrated
- Low/moderate heat flux - convection effects important
- High heat flux – source effective emissivity important
# Presentation: 333208

## Options Value in R&D

- Gregory L. Hamm, PhD
- Greg Hamm and Associates
- 933 Taylor Avenue
- Alameda, CA 94501
- Phone: 510-918-2016
- email: greghamm@attbi.com

## Definitions of options vary

**Presented in white paper - Technologies that do not enter under the most likely scenario, but may enter under others**** **
**Common - Something you can do**
**Finance (call) - Right but not the obligation to buy a security at a fixed price on a future date**
**Real Options Valuation - Flexibility to adopt future actions after learning**

## The practice of Real Options Valuation has a common set of activities

**Identify uncertainty (volatility of underlying asset(s) or other expression)**
**Define the learning process**
**Define the flexibility available**
**Calculate outcomes**
**Price the outcomes (replicating portfolio, risk neutral probabilities, discount rates)**
**Calculate expected value**

## The white paper suggests an expected value approach that differs from current practice

**Current DOE practice implied by white paper - Value the new technology under a most likely scenario**
**Options analysis **
**Define multiple possible scenarios (should be mutually exclusive and collectively exhaustive)**
**Assume an option on technology adoption**
**Favorable future, adopt**
**Unfavorable future, do not adopt**
**Calculate the expected value over the scenarios**

## Transition to this approach may face many difficulties

**Identifying appropriate scenarios**
**Assigning probabilities to scenarios**
**Assuring credible and unbiased scenarios and probabilities**
**Conflicts between probability and policy**
**New skills for evaluators**

## Adopting a broad view of options would have significant value

**Valuation is not separable from strategy.  Strategy formulation should include a search for options. Undiscovered options are not valued or acted upon**
**Markets provide useful information on value**
# Presentation: 726426

## Operational Control

## What is Operational Control?

- Defined by FAA as:
- “Exercis[ing] authority over initiating, conducting or terminating a flight.”
- System of controls over aircraft and crew by qualified individuals
- Ensure safe service to public

## FAA Guidance Pre-Accident 

- Operations Specifications -  no specific details of operational control methods
- Commonly little more than flight locating procedure

## FAA Guidance Pre-Accident

- Crews and aircraft not directly overseen by carrier safety personnel
- Obscured owners from FAA oversight

## Loss of Operational Control

## Result of Loss of Control

- Environment conducive to deficiencies
- Widespread industry practice

## FAA Actions Post-Accident

- Clarified existing regulation
- Federal Register Notice to inform industry
- Series of seminars to educate

## Ops Specs Draft

- New version of Ops Specs order includes specific operational control guidance
- But not yet in effect
- Staff proposes recommendations in this area

## Slide 9

## Ownership

- DDH/448 Alliance

## Flight Booking

- Customers
# Presentation: 049863

## Myocardial Perfusion Imaging in the Pediatric Population

- Peter Gardiner, MB ChB, MRCP
- Vice President, Medical Sciences
- Bristol-Myers Squibb Medical Imaging

## Bristol-Myers Squibb Medical Imaging

- A worldwide leader in cardiovascular imaging research
- Product line includes:
- Cardiolite® (Kit for the Preparation of Technetium Tc99m Sestamibi for Injection)
- Definity® (Vial for Perflutren Lipid Microsphere Injectable Suspension)
- Committed to appropriate evaluation of imaging drugs and cardiac imaging procedures in children
- Focus on nuclear myocardial perfusion imaging (MPI)

## Nuclear Myocardial Perfusion Imaging

- Only modality approved by FDA for assessment of myocardial perfusion and function
- >13 years experience with Tc99m agents
- Indications:  Perfusion; function; exercise and pharmacologic stress
- Extensive literature documenting use in diagnosis, prognosis and risk stratification
- Safe and well tolerated
- Continued growth in usage

## Cardiolite®(Kit for the Preparation of Technetium Tc99m Sestamibi for Injection)

- Launched in US in 1991
- Indications:  myocardial perfusion and function; exercise and pharmacologic stress; developing information for use in patient management decisions
- Leadership position:
- Clinical use
- Continued significant investment in Clinical Research and Education

## Nuclear Myocardial Perfusion Imaging in Children

- Lack of substantial, well-controlled clinical studies to define dosing and efficacy
- Usage - ~ 2-3,000 studies in 2002
- Patient populations:
- Kawasaki’s Disease
- Cardiac transplant vasculopathy
- Cardiomyopathies (including hypertrophic and drug-induced)
- Congenital heart disease, including anomalous LCA

## Nuclear Myocardial Perfusion Imaging in Children

- Advantages
- Extensive experience and FDA approved for use in adults
- Operator independent
- Reduced dose and duration of imaging with Tc99m based agents
- Disadvantages
- Radiation exposure
- Limited information on dosing (only weight-based)
- Lack of substantial efficacy data

## Nuclear Myocardial Perfusion Imaging in Children

- Summary
- Nuclear imaging is the only modality approved by FDA for assessment of myocardial perfusion and function in adults
- Extensive experience in adults
- Limited and variable experience in children
- Bristol-Myers Squibb Medical Imaging (BMS MI) supports FDA’s initiatives to evaluate nuclear cardiac imaging in children
# Presentation: 334308

## Tii...

- Elizabeth Dickey, Penn State Univ. and Susan Sinnott, Univ. of Florida

- TiO2 is used in a wide variety of electrical, dielectric and sensing applications. Point defects in the crystalline lattice play an important role in its electronic and functional properties. We have developed a computational approach that integrates first-principles electronic-structure and thermodynamic calculations to determine point defect stabilities in TiO2 over a range of temperatures, doping levels and oxygen partial pressures. This data allows us to *predict* material nonstoichiometry and electrical conductivity as a function of the material environment.

- 5nm

*(Figure Right) Stability diagrams for predominant point defects in TiO**2** as a function of temperature, oxygen partial pressure and Fermi level (****F**).  Ti**i **represents a titanium interstitial, V**o** a vacancy on an oxygen site and V**Ti **a vacancy on a titanium lattice site.  The superscript denotes the charge ( ****‘ ****positive and **.** negative)*

**V****O****x**

**Temperature (K)**

**Ti****i****...**

**Ti****i****.**

**V****O****..**

**V****Ti******

**V****Ti******

**ε****F****=1.5eV**

**ε****F****=2.5eV**

**Oxygen Partial Pressure, log(P/P****0****) **

*(Figure Below) Atomic model of a Ti ion in an interstitial site, denoted Ti**i** , in the TiO**2** crystalline lattice.*

## Research Experiences for High School and Undergraduate Students in  Oxide Electroceramics DMR-0303279  Elizabeth Dickey, Penn State Univ. and Susan Sinnott, Univ. of Florida

- Mentoring and training both undergraduate and high school students is an integral part of the research program. John Foreman, an undergraduate student at Penn State, has been gaining valuable research exposure and experience by selectively doping TiO2 to study the effects on grain boundary properties. This experience has motivated John to pursue a graduate degree in Materials Science after his graduation in Dec. 2006.
- Riley Butler, an undergraduate student at UF, has been working with UF graduate students Jun He and Patrick Chiu to carry out combined electronic structure and thermodynamics calculations to determine defect formation energies in metal oxides. Leah Nation also worked with Patrick Chiu to carry out molecular dynamics simulations of oxide surface chemistry. She was a UF Student Science Training Program participant during the summer of 2006.

- Leah Nation and Patrick Chiu at the University of Florida, July, 2006
# Presentation: 424698

## Planetary Subsurface Sample Acquisition System

**S**mall
**B**usiness
**I**nnovation
**R**esearch

**Honeybee Robotics, Inc.**

- New York, NY

**ACCOMPLISHMENTS**
- Evaluated five different systems for sample acquisition and transfer
- Selected system is capable of obtaining intact core samples at up to 5 cm depth from rocks or bedrock
- Samples can be positioned for analysis by instruments in instrument arm
**COMMERCIALIZATION**
- Automated ground sampling system for agriculture or hazardous waste site mapping

**GOVERNMENT/ SCIENCE APPLICATIONS**
- Received $2.2 million contract for Mars 2003 and 2005 Lander missions
- Won related contract for deep space 4/Champollion Mission

***Field Integrated Design & Operations Rover Illustrates  ***
***Planned Configuration for Mars Rovers***

- 1995 Phase II; NAS8-97034
- Success Story # 7-014

- Jet Propulsion Laboratory

**INNOVATION**
- Miniature planetary subsurface sample
- acquisition and transfer system
# Presentation: 085819

## Slide 1

## Slide 2

## Slide 3

## Slide 4

## Slide 5

## Slide 6

## Slide 7

## Winter  1904

- Lawyers and patents
- St. Louis  competition
- Dealing with the press
-        Reports of the first flight
-        The Rascals D.A.Willey – and A. Herring
- Begin  work  on  3  engines
-        4 inch  bore  -  4  cylinder
-        4 1/8  inch  bore – 4 cylinder
-        4 inch  bore  -  8 cylinder (never completed)
- Begin  work  on  3  airframes
-         Assemble the ‘04

## Slide 9

## Spring 1904

- Begin mid-May
-         Press Invited
-         Engine problems
-         Weather problems
- Handling problems
-          Stalls
- Decide to move CG  in July
- Propulsion  tests

## Slide 11

## Slide 12

## Summer 1904

- Gaining experience
- Begin to make turns  (Flt 15 - Aug 2)
- Take-off  problems (236 ft track)
- Many crashes  -  pine spars
- Propulsion  tests
- Exceeds KH flight  (1340 ft  Flt 28 -Aug13)

## Slide 14

## Slide 15

## Slide 16

## Slide 17

##  Fall  1904

- First use of  catapult (Flt 40 – Sept 7)
- Half circle (Flt 49 – Sept 15)
- First  complete circle (Flt 52 – Sept20)
-          Spectators
- Propulsion tests
- Can’t  stop turns (Flt 54 – Sept 26)
- Increase altitude – fly over cattle (Flt 70 – Oct14)
- Stake pulled out!
- Multiple circle flights (Flts 68, 70, 75 ,80, 82, 87, etc.)
- 4 circle-5 minute flights (Flt 82 – Nov 9) (Flt 100 – Dec 1)
- Accidental engine shut-offs
- 105 flights -  45 total minutes by Dec 9

## Slide 19

## Slide 20

## Winter & Spring 1905

- Alternate  locations
- Propulsion  tests
- Finish  new airframe
- Letters to the War Department
- Foreign visitor

## Summer 1905

- Begin new flight tests Jun 23
- Problems with early flights
- Design changes
-         blinkers
-         separate rudder control
- Big crash (Flt 9 – Jul 14)
- Re-design front rudder
- Resume flights Aug 24
- Duplicate best ’04 flight by Flt 21-Sep 6

## Slide 23

## Slide 24

## Fall 1905

- Multiple  circle flights (Flts 15, 17, 21, 22, 23, 24)
- First figure 8 (Flt 25-Sep 8)
- Propulsion tests
-        New props and sprockets on Sept 25
- Enlarge and move rudder
- Sep 26 – 18 min flt,  Sep 28 – 9 min flt
-                   The Honey Locust
- Sep 29  - 20 min flt,  Sep 30 – 17 min
- Oct 3 – 25 min,  Oct 4 – 33 min (hot bearings)

## Slide 26

## Slide 27

## Slide 28

## Slide 29

## Slide 30

## Slide 31

## October 5, 1905

-   (Flt 48) – 24 1⁄2  miles -  38  minutes  3 sec
-   fuel exhausted
-                  Mission  Accomplished
- Story  appears in  Daily News and Cinci Post
- Experiments discontinued for the present
- Letter to Secretary of War
# Presentation: 070485

## ISTP spacecraft show direct penetrationof solar wind particles into magnetosphere

**It is known that energy, momentum, and mass pass from the solar wind into the magnetosphere **
**Advanced instrumentation on POLAR and ACE use ionized ions to directly                                      track particles (like dye in a flow of water)**

**MEASUREMENTS:**
-  Ace SWICS, outside the magnetosphere, measured the variable charge state of iron at solar wind energies (keV).
-  POLAR CAMMICE, moving in and out of the cusp, measured the charge state at accelerated energies (tens of keV).

**OBSERVATIONS:**
- When POLAR was in the cusp (tan intervals):
-  And the interplanetary magnetic field had a southward component (Bz south), there was good agreement in the variation of the charge state (right two tan intervals).
-  And Bz was north – delayed agreement (second tan interval)

**INTERPRETATION:**
-  Bz south allows direct entry of solar wind into the cusp.
-  Bz north causes considerable delay in entry.

**IMPLICATIONS:**
- Specific constraints on models of particle transport and acceleration through magnetosheath and magnetopause.

- Composition of Iron in the May 2, 1998 CME  (red line) was highly variable yielding an easily recognizable pattern in the Earth’s Magnetosphere (+ marks).

## POLAR spacecraft detects new species of aurora in response to interplanetary shock

**MEASUREMENTS:**
- POLAR UVI LBHL filter (~170 nm) images of northern auroral zone during CME induced solar wind pressure pulses

**INTEPRETATION:**
-  Increases in solar wind pressure compress the frontside magnetosphere
-  Preexisting plasma on outer zone magnetic field lines become energized by absorbing part of the impinging energy
-  Energized particles are scattered into the ionospheric loss cone colliding with upper atmosphere neutrals to produce intense aurora
-  The dayside aurora expands toward dawn and dusk as the compression proceeds across the magnetosphere

**OBSERVATIONS:**
- When an IP shock or pressure pulse impinges on the magnetosphere, fast auroral propagation starts at local noon and moves towards the dawn and dusk flanks.

**IMPLICATIONS:**
- Shock induced, dayside auroras and associated particle heating may be a driver for the enhanced ionosphere outflows recently connected with interplanetary shock events.

**MEASUREMENTS:**
- POLAR UVI LBHL filter (~170 nm) images of northern auroral zone during CME induced solar wind pressure pulses

**OBSERVATIONS:**
- When an IP shock or pressure pulse impinges on the magnetosphere, fast auroral propagation starts at local noon and moves towards the dawn and dusk flanks.

- Unique filters (~150-170 nm) on the POLAR UVI instrument allow space-based imaging of the dayside aurora with minimal signal distortion from dayglow
# Presentation: 182541

## Pricing Update

***MTAC***
***August 3, 2006***

***or the***
***“ ******I’m no Ashley Lyons Tour ”***** **

## I’m no Ashley Lyons...

**When I talk, I usually say something**
**I have no Alabama stories**
**I dance to music....**
**	****...****.he just dances**
**I actually have feelings**
**He is usually..... ****right**

## High-Level Initiatives

**Shape-based pricing**
**Less emphasis on weight**
**Incentives**
**Containers**
**Drop shipping**
**Sorting**
**Packaging**
**More choices**
**Forever Stamp**
**Low-cost Address Change Service**

## Where We Are

**92 days since filing**
**30% through 10-month timeline**
**54 Interveners**
**Hearings from August 3 to August 30**
**2,600 interrogatories by 26 interveners**
**Intervener proposals September 6**

## Timeline

**2006 ** **                                                2007**
- May      Jun      July      Aug      Sep      Oct      Nov      Dec      Jan      Feb      Mar       Apr      May     Jun

**Governors Decision ****(March/April)**

**Implementation ****(May/June)**

**PRC Recommendation ****(Early March)**** **

**Litigation ****(May through March 2007)**

**Filing Date**** ****(May 3, 2006)**

**10 Months**

**1 Year**

## Issues

**Wide variety of issues**
**large and small**
**Federal Register process**
**we understand the importance**
**appreciate patience and input**
# Presentation: 526201

## Light Driven Waste Remediation SystemUtilizing Phototrophic BacteriaMicro-Bac International, Inc.Round Rock, TX

**Innovation**
- This SBIR project resulted in a new system for the treatment of wastewater based upon the metabolic activity of phototrophic bacteria.

**Accomplishments**
- This system requires no aeration, uses sunlight as an energy source, and does not generate carbon monoxide.  It also offers significant advantages over conventional aerobic or anaerobic waste treatment systems in terms of flexibility, safety, cost effectiveness and performance.
- In geographical areas with adequate amounts of sunlight, this system is considerably more cost-effective than traditional activated sludge aerobic systems.
**Commercialization**
- Micro-Bac International, Inc.SM in its Central Texas research laboratories has developed and manufactured this microbial biotechnology for the successful treatment of wastewater systems.  Micro-Bac’s natural biological solutions are comprised of a proprietary combination of bacteria used to accelerate the natural degradation of wastes in wastewater systems, ponds and lagoons, as well as food processing and animal waste collection systems.
- Currently Micro-Bac International, Inc. is actively pursuing a contract with a Brazilian multinational glass producer to manufacture and distribute the treatment cells.  The microorganisms developed as part of the NASA SBIR contract are being presently sold as a liquid product, Mega-Bac TFTM.
- Mega-Bac TFTM  works on the degradation of fat, oil, fecal material and other biologically derived wastes.  The metabolic processes of Mega-Bac TFTM produce the enzymes necessary for degrading septic wastes and reducing odor.  Sales of this product are in excess of $350,000 at the present time.

**Government/Science Applications**
-  Applications of this system are numerous, because water purity is of increasing concern for drinking and pharmacological uses, as well as for environmental quality.  Potential applications include wastewater treatment for agriculture, small communities, individual homes, isolated military installations, food processors, and chemical manufacturing.

- Points of Contact:
-    -  NASA (Denise Swain; 205/544-0968)
-    -  Micro-Bac (Terry Nelson; 512/310-9000)
- 1991 SBIR Phase 2;  NAS8-39918

- Marshall Space Flight Center
-   Date of Update:	2/24/98
- Success Story #:	8-001

- This large petrochemical firewater lagoon was successfully treated with the biological solution Mega-Bac TFTM manufactured and distributed by Micro-Bac International, Inc.SM
# Presentation: 525814

## Gene Therapy for Arthritis, Musculoskeletal, and Skin Diseases

**Group leaders and participants**
**-Dr. Glen Nuckolls****	****	****	****  ****-Dr. Paul Robbins**** **
- Program Director 			   •Professor, Microbiology and Molecular Genetics,
-  Division of Musculoskeletal Diseases, NIAMS	     and Biochemistry
- 				     University of Pittsburgh
**-Dr. Carl C. Baker****	****	****	**
- Program Director
-  Division of Skin and Rheumatic Diseases, NIAMS**	****  ****-Dr. Dennis Roop**
- 			    	   •Charles C. Gates Chair of Regenerative 				   	    Medicine and Stem Cell Biology
**-Ms. Shahnaz Khan**			   University of Colorado Denver**	**
- Clinical Coordinator
-  Division of Extramural Research Activities, NIAMS
**-Ms. Anna Nicholson**
- Clinical Coordinator
-  Division of Extramural Research Activities, NIAMS
**-Dr. Louise Rosenbaum**
- Science Policy Analyst
-  Office of Science Policy and Planning, NIAMS
**Overarching question**
- -What high priority, basic research questions should be addressed to advance
-   the field of gene therapy?

-  2008 NIAMS Scientific Retreat

## Uses of Gene Therapy

**Advantages of gene therapy (GT)**
**	**-Potential replacement or correction of single gene defects
- 	-Up- or down-regulation of pathways involved in pathology or natural repair mechanisms
- 	-Synthesis, processing, and delivery of GT products at the disease site
**Application of GT to Arthritis, Musculoskeletal, and Skin Diseases**
**	**-Wound-healing:  delivery of platelet-derived growth factor b gene to lesions
- 	-Rheumatoid arthritis:  injection of *ex vivo*-manipulated synovial cells into joints
- 	-Osteoarthritis:  targeting interleukin 1 receptor antagonist gene to affected knee joints
- 	-Limb-girdle muscular dystrophy:  intramuscular delivery of alpha-sarcoglycan gene

-  2008 NIAMS Scientific Retreat

## Points of consideration

**Vector optimization, selection, and delivery**
**	**-*In vivo* delivery, *ex vivo* manipulation options
- 	-Stem cells:  only curative approach
**Immune response**
- 	-Primary obstacle for successful GT
- 	-Approaches:  transient immune suppression, long-term tolerance strategies
**Infrastructure and resource needs**
**	**-Central services for pre-clinical testing and vector production
- 	-Activities (meetings, funding opportunities) to facilitate formation of multidisciplinary
-        collaborations
**Regulatory and review issues**
**	**-Increased federal requirements
- 	-Importance of multidisciplinary peer review for GT grant applications

-  2008 NIAMS Scientific Retreat
# Presentation: 495384

## Metrics for Performance Evaluation of Distributed Application Execution inUbiquitous Computing Environments

- Prithwish Basu
- ECE Department, Boston University
- _[pbasu@bu.edu](mailto:pbasu@bu.edu)_
*(Joint work with Wang Ke and Thomas D.C. Little)*
- Project URL: http://hulk.bu.edu/projects/adhoc/summary.html

- This work was supported in part by NSF under Grant #ANI-0073843

**ACM UbiComp’01 Workshop on **
**Evaluation Methods for Ubiquitous Computing**

## Overview of our Project

- We are investigating techniques for modeling distributed UbiComp applications
- Logical representation of applications in terms of component sub-tasks as *resource dependency graphs* or *task graphs*
- Physical resources are selected *on-the-fly* just before actual execution of task
- Focus: Distributed protocols that are adaptive to network partitions due to user/device mobility

## A Smart Presentation Application

- Keyboard

-  Mouse

- Smart Storage/CPU
-   (possibly mobile)

- Overhead
- Display

-  Local
- Screen

- Wireless PDA
- (mobile user)

-   auxiliary devices
- to control presentation
-    (can be moved)

- presentation data

- summary

- The user does not care which *particular*
- devices perform the presentation

## Task Graphs and Embedding

- U

- A

- B

- C

- Task Graph

- a1

- d2

- a2

- b1

- b2

- c1

- c2

- u

- d1

- a1

- d2

- a2

- b1

- b2

- c1

- c2

- u

- d1

- Embedding 1
-    Aa1
-    Bb2
-    Cc2

- Embedding 2
-    Aa2
-    Bb1
-    Cc1

- nodes (colors indicate
- distinct device categories)

- non-tree edge

- tree edges

## Metrics to Evaluate Performance

| Category | Symbol | Unit | Description |
| --- | --- | --- | --- |
| Speed | T-embed | sec. | Time taken to discover a mapping |
| Quality | Dilation | hops | Avg. stretch of TG when mapped onto G |
|  | Node Congestion | +ve Real number | Avg. number of mapped paths passing through a node in G |
| Efficiency | Overhead | #pkts | Messaging overhead to find an embedding |
| Resilience to Mobility | FrqDisrupt | /min. | Frequency of application disruption |
|  | T-recov | sec. | Time to recover from an app. disruption |
| Application perf. after embedding | EffThrpt | in [0,1] | #ADUs recvd. at sink / #ADUs that should have been recvd. under ideal conditions |
|  | Delay | msec. | Time taken by an ADU to reach destn. |
|  | NumRe-Tx | /flow | #Re-Tx at source needed for a data flow |

## Variable System Parameters

- Topology related:
- #Devices in network ~ richness of network connectivity etc.
- Fraction of devices that rely on wireless AP / ad hoc routing
- Mobility patterns: random  highly predictable
- Task Graph related:
- #nodes in a task/resource graph
- Complexity of relationships between nodes of a task graph
- #Instances of resources in a network with similar capabilities
- Traffic related
- Average data rates of applications
- Background traffic patterns: low load  heavy load
- #Instances of simultaneously running tasks
# Presentation: 061618

## Who are we?

- Geological oceanographers
- Use geophysical tools to obtain images of seafloor and its subsurface.
- Use geological tools to groundtruth these images.

## Slide 2

## Sedimentary process studies

## Geologic framework studies 

## Karstified Eocene Limestone Surface

## Marsh Hammocks

## Bedrock Control on Marsh Hammocks

## Slide 8

## Slide 9

## Slide 10

## Slide 11

## Slide 12

## The past...

- Widely spaced track lines producing incomplete benthic maps
- Poor navigation
- Analog, limited digital acquisition and processing
- Map products hand constructed on computers
- Labor intensive

## Bedforms on Suwannee River Bottom

## Limestone Outcrop on Suwannee River Bottom

## Slide 16

## The present, future...

**The present, future...**

- Precise navigation
- Digital acquisition and processing
- Computer generated maps
- Precise bathymetry
- Seafloor classification systems
- Map benthic habitats

## Slide 18

## Slide 19

## Slide 20

## We propose...

- Baseline bathymetric, benthic habitat, and seafloor mapping for the lower Suwannee River and the adjacent inner continental shelf.
- These tools are essential in ecosystem management; can be used to ask more fundamental questions.
# Presentation: 541285

## Mandarin STD 2006 Results

- Jonathan Fiscus, Jérôme Ajot, George Doddington
*December 14-15, 2006*
- 2006 Spoken Term Detection Workshop

- _http://www.nist.gov/speech/tests/std_

## Outline

- Evaluation results
- Corpus statistics
- Participants
- Results
- Future directions

## Evaluation Corpora

- Data Sources - Rich Transcription 2003 and 2004 Test Set
- BNews: China Central Television, Radio Free Asia, New Tang Dynasty TV (~1 hour)
- CTS: Hong Kong Univ. of Science and Tech. collection  (~1 hour)
- Transcripts:
- Transcribed by the LDC for EARS
- Word segmentation done by a native speaker
- We need to check the results to see if this had and impact

## Mandarin Term Profile

- Followed the same selection protocol English
- Trigrams, bigrams, and unigrams
- Selected by Y.C. Chang

## STD 2006 Mandarin Participants

|  | CTS Only |
| --- | --- |
| BBN | 1p  |
| DOD | 1p, 1c  |

## Mandarin CTS

| Site | Indexing Rate | ATWV | MTWV |
| --- | --- | --- | --- |
| BBN | 14.8 Hp/Hs | 0.346 | 0.344 |
| DOD | 12.8 Hp/Hs | -1.020  | 0.023  |

## Conclusions

- Evaluation completed
- Highest ATWV on CTS data: 0.346
- Still lots to do for this data
- Study the impact of word segmentation on scoring
- Conditioned analysis needs completed
# Presentation: 154624

## Profit: A spectral analysis GUI

- Randall Smith
- James Peachey

## Spectral Analysis Needs

- Users with high-resolution spectra (with ~104 bins) would like a new analysis tool in addition to XSPEC (or Sherpa).
- This tool must:
-  Understand standard X-ray spectra data formats
-  Have easy-to-use interface
-  Link to existing atomic databases
-  Connect to existing spectral tools (XSPEC, Sherpa)
-  Be freely distributable

- Plus, of course, it must do some useful analysis tasks!

## Existing Similar Tools

**PintOfAle**: Useful tool, but requires IDL and focused on stellar coronae issues
**ISIS**: Requires S-lang competency to use efficiently.
**vWhere**: Good framework, but focused on event data, rather than spectral analysis.

## Genesis of Profit

- Randall: Visualized GUI tool that would allow easy plot selections, line identification and fitting and would link to the ATOMDB.
- James: Currently developing GLAST software using the (free) ROOT toolkit, a robust set of libraries used extensively by the high-energy community and extremely well-supported.
- Fortunately, the two met years ago and resumed having semi-regular lunches after Randall returned to Goddard...

## Existing Features

-  Displays fixed thumbnail & scrollable main plots
-  Modifiable plot features (linestyle, color)
-  Finds lines from ATOMDB that match plot
-  Can convert energy spectral to velocity spectra
-  Stores & restores subplots
-  Fits spectral with simple Gaussian fits (via ROOT intrinsics)
-  Internal ability to handle either wavelength or energy data

## (Some) Future Plans

- Fitting
-  Do complex fitting through interface to XSPEC
-  Generate XSPEC xcm file to load observed subplot immediately
-  Display plot residuals
- Line Identification
-  User filters on line id list (ie, only Fe lines, only He-like, etc)
-  Temperature -selected line id list, rather than peak emission
-  Display implied lines (ie, Fe XVII 3C line implies a 3D line)
-  Create latex table from line id, fluxes
- Support for absorption spectroscopy (sort by oscillator strength)
- Plot Display
- Show/hide error bars; allow rebinning, smoothing, etc
-  Using input redshift, show in observed or source frame
- Overlay (or co-add) individual line spectra in velocity space
-  Display observed line ratio and temperature/density curve

## And now a screenshot...

## A sufficiently advanced technology is indistinguishable from a rigged demo...

- 			...paraphrasing Larry Niven
# Presentation: 531325

## Reconciling STEM & SAXS for Ionomer MorphologiesKaren I. Winey, University of Pennsylvania, DMR- 0549116

**N****2D**** ~ 164**

- Reconciling STEM & SAXS for Ionomer MorphologiesKaren I. Winey, University of Pennsylvania, DMR- 0549116

-   SAXS analysis includes the Yarusso-Cooper model (yellow) and Lorentzians for the higher angle peaks associated with polystyrene (blue).
-   To account for overlap in the STEM images, we simulated the 3D real-space morphology (far left) using the fitting parameters for the scattering model and project a 2D image (left).  The ratio of 3D objects to 2D features depends on the specimen thickness (t).  Thus, the local specimen thickness, as determined by EELS during the STEM experiment, was used to determine the corresponding number of 3D objects.  The number density density determined by SAXS and STEM are in agreement.

- Benetatos, Heiney, Winey, *Macromolecules*, 2006.
- Benetatos, Chan, Heiney, Winey, in preparation.

- t = 25 nmN3D=3125

**SAXS**Yarusso-CooperFitting ParametersR1 = 0.5 nm
- RCA = 0.75 nmVp = 5 nm3

**Simulations**

***First**** quantitative reconciliation of size (R**1**) and number density (1/V**p**) of ionic aggregate in an ionomer, namely Cu-neutralized poly(styrene*-ran*-methacrylic acid)*.

## Reconciling STEM & SAXS for Ionomer MorphologiesKaren I. Winey, University of Pennsylvania, DMR- 0549116

**Summer 2006 REU**
- Bruce Hilman worked closely with Prof. Winey for 12 weeks testing the rheological and adhesive properties of polyethylene-based ionomers.  These materials are being explored for new cryogenic applications in an emerging collaboration with between UPenn and NASA.

**With the Public**
- Transferring the enthusiasm for emerging science and new technologies is a hallmark of Prof. Winey’s classroom teaching and public forums. Earlier this year Prof. Winey met with high school teachers over lunch at the American Physical Society Meeting. Pictured below are pre-college students learning about materials science.

- Reconciling STEM & SAXS for Ionomer MorphologiesKaren I. Winey, University of Pennsylvania, DMR- 0549116

**Polymer Electron Microscopy Expertise**
- Electron microscopy of polymers appears to be a vanishing expertise in industry.  Prof. Winey, in collaboration with Penn’s Regional Nanotechnology Facility, is tutoring active scientists from a variety of settings about the power of standard electron microscopy as well as the analytical electron microscopy methods developed within this grant._[ ](http://www.arkema-inc.com/index.cfm)_
# Presentation: 025543

## An IT Application Developer’s View of AT Interoperability

- Andrew Kirkpatrick
- Adobe Systems
- February 7, 2007

## The Big Picture

- Adobe wants to do the right thing for users
- Adobe wants implementing the right thing to be easier to accomplish

## Adobe Reader and PDF

- Pre-1998:  inaccessible to AT
- Need to convey rich document information to users
- Headings
- Tables
- Digital Signatures
- Comments
- Implemented MSAA on Windows to deliver information to AT

## Accessibility Implementation

- MSAA did not have everything that was needed
- Adobe needed to augment the API in minor ways
- Adobe needed to work closely with Assistive technology vendors to ensure that support for the specific implementation, including the modifications was interpreted correctly
- Over time, additional improvements were required
- Adobe specified some new control types in its implementation (e.g. Digital Signature)
- Adobe defined a new Document Object Model to convey additional information (e.g. headings)
- Working closely with assistive technology vendors is required for support.

## What we need

- The ideal accessibility API would allow developers to have a reasonable expectation that AT support would be simplified.
- Support for additional platforms would be simplified
- Every addition to an API or new API adds demands on resources for AT support
- ...for every AT to be supported
- IT has a limited capacity to work with AT
- The more comprehensive the API, the lower the investment for IT and AT.

## Slide 6
# Presentation: 037886

## Updates

- Toured pBar tunnel
- Once cooling hardware is removed, there will be lots of room for any sort of resonance or extinction hardware we want.
- Working on optimum harmonic magnet placement
- Still assuming half integer extraction
- Looking at JParc extraction scheme
- Thanks to Kevin Brown for Sending Material

## Beamline availability

- Debuncher has three identical dispersion-free straight sections
- 13 quads each
- One filled with cooling pick-ups
- One filled with cooling kickers
- One filled with RF
- Once cooling goes away, it will free up lots of space
- Assume RF may be more distributed

## Resonance driver placement

- Consideration
- Want to arrange driving quads in pairs of opposite sign to cancel overall tune shift.
- Want pairs for which driving term (19) is an odd number of  appart, so they add.
- Choose
- Six locations just inside of the ’07 quads at the ends of the straight sections

- Pairs indicated by color

## JParc Scheme

- Technical Design Report
- Drive 67/3 resonance from below with two families of 36 sextupoles each
- Extract with an electrostatic septum of 170 kV/25mm made out of 100 micron wire @ 1.25 mm spacing over 1.5 m
- Inefficiency of
- 2.5% with fixed bump
- 1% with dynamic bump
- Upgraded proposal
- 30 micron ribbon + prescatterer
- Inefficiency of << 1% (Talk claims .1%)
- Are they building this?
- Should work for us

## Plans

- Continue to pursue half integer resonance
- Hopefully have it into Optim model by next meeting.
# Presentation: 170046

## NOAA Research Hot Items: Implementation

- Eugene F. Burger UW/JISAO – NOAA/PMEL
- Nancy N. Soreide NOAA/PMEL
- Pacific Marine Environmental Laboratory / NOAA
- eugene.burger@noaa.gov

**Hot Items site functionality described in AMS IIPS paper J11.4 by Nancy Soreide**

## Overview

- Background
- Version 2 Requirements
- Technologies used
- Database schema/design
- Server architecture
- Access control
- Looking ahead
- References

- AMS / IIPS 13 - 17 January 2002

## OAR Hot Items is ...

- A web site which allows a user to enter an OAR newsworthy story which is then made available to OAR users on the OAR Hot Items site as a headline on a summary page.  A user can then click this headline to read the full story detail.
- Version 2 went public in July 2001.

- AMS / IIPS 13 - 17 January 2002

## Version 2 requirements

- Story templates
- Free form entry
- Publication announcement
- Media event
- Conference/workshop meeting announcement
- User access permissions
- Localized (lab) level pages
- Enhanced secure user functionality

- AMS / IIPS 13 - 17 January 2002

## Page associations

**Pages separated into 5 categories**
- Secure
- Lab level
- OAR level
- Public
- Lab level
- OAR level
- Help

**NOAATech 2002**

- AMS / IIPS 13 - 17 January 2002

## Technologies used

**Database**
- MySQL
- C (database housekeeping)
**Server side scripting**
- PHP 4
**Server**
- Apache & SSL
**Client**
- Web pages (HTML, SSL etc)

- AMS / IIPS 13 - 17 January 2002

## Database schema

- AMS / IIPS 13 - 17 January 2002

## Database schema (Cont.)

- Single database for whole site
- Story tables
- Story detail
- Story summary table for each story type Story contact table
- User information table
- Operating unit (lab) information table

- AMS / IIPS 13 - 17 January 2002

## Database schema (cont.)

- Configuration information table
- Indexed on story publish time
- Separate database users for
- Public users
- Secure users
- Access verification
- Administration

- AMS / IIPS 13 - 17 January 2002

## Server software

- IP access control for site.
- Skeleton PHP pages reference PHP libraries.
- Libraries located outside server web area.
- Libraries for page headers, footers and content.
- Secure pages served via SSL server.
- Each secure area page access controlled.
- Session variables to maintain user session state.

- AMS / IIPS 13 - 17 January 2002

## Access control

- Access level on each secure page
- User access level represented in10 bit binary word
- Saved as integer
- User and page values compared to grant access

- AMS / IIPS 13 - 17 January 2002

## Looking ahead

**Enhancements**
- Changes to story entry templates
**Added functions**
- E-mail bulletin functionality
- Third access level?

- AMS / IIPS 13 - 17 January 2002

## More information?

**Hot Items**
- hotitems.oar.noaa.gov
**PHP**
- www.php.org
- www.devshed.com
**MySQL**
- www.mysql.com

- AMS / IIPS 13 - 17 January 2002
# Presentation: 665083

## APS Detector Initiatives

**BESSRC CCD Detectors**
-  CCD X-ray detector
-  Single CCD and **2x2 Mosaic** of CCDs
-  1.75 Demagnification Fiber-Optic Taper
-  Kodak KAF-4320E CCDs
-  2084 x 2084, 24m pixels
-  QE of .65
-  Readout in .2 sec (5 fps)
-  Deployment: last quarter of 2006.

**Fast CCD X-ray Detector (FCCD)**
-  LBNL and ANL Collaboration
-  Custom CCD with almost **column-parallel readout**
-  Fast Readout IC with Pipeline ADCs (FRIC)
-  Low noise (~ 10 electron read noise)
-  Large Dynamic Range of 14+ bits
-  First **prototype** CCD currently in fabrication
-  480 x 480 CCD with 30 m pixels
-  Target of 2.5 ms readout (400 fps)
-  Thick depletion region (250 m)
-  Direct detection & phosphor-coupled models
-  Prototype Camera System expected early 2007

**LBNL Contributions**
-  Custom CCD
-  Custom Fast Readout IC
-  Mechanical, Optics and Cooling

**ANL Contributions**
-  DAQ Readout Electronics
-  User Interface
-  Image Processing

**APS Detector Initiatives**
- XSD - Beamline Technical Support Group

- _John T. Weizeorick_ 1, Patricia Fernandez 1, John Lee 1, Tim Madden 1, Antonino Miceli 1, Steve Ross 1, Michael Molitsky 2, Daniela Capatina 3, Matthew Church 4, Howard Padmore 4, Peter Denes 5, Jean-Marie Bussat 5, Jean-Pierre Walder 5
- 1 XSD – APS - Argonne National Laboratory, 2 Biosciences Division - Argonne National Laboratory, 3 AES – APS - Argonne National Laboratory, 4 Experimental Systems Group – ALS - Lawrence Berkley National Laboratory, 5 Engineering Division - Lawrence Berkley National Laboratory

**http://www.aps.anl.gov/Xray_Science_Division/Beamline_Technical_Support/Detector_Pool**

**GE a-Si flat panel**

**Detector Pool**
-  GE Amorphous Silicon Flat Panel
-  mar 165 CCD Detector (2)
-  mar 345 Image Plate (2)
-  Ketek Silicon Drift Diode (6)
-  Radiant Technology Vortex SDD (5)
-  Single & multi - element Germanium (3)
-  Bruker 6500 CCD Detector
-  Photometrics Roper Cool Snap (2)
-  Detector Test Facilities
-  ~300 requests per year from entire APS community

- Argonne National Laboratory is a U.S. Department of Energy laboratory managed by The University of Chicago.

- Use of the Advanced Photon Source was supported by the U. S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract No. W-31-109-ENG-38.
# Presentation: 036329

## Shuttle RMS Inspection Capability (Bottom View)

- White areas indicate ANALYTICAL resolution is within critical damage size criteria

- Black areas indicate ANALYTICAL resolution is not acceptable

- +

- +  Area where black mesh gridlines merge on curved surface appear black. Area resolvable within critical damage size criteria.

- +

- Note: Black mesh gridlines in white areas are artifacts of mapping program and are within critical damage size criteria.

- Based on imagery captured with a CTVC at max zoom,
- recorded to DVcam digital video tape and downlinked over the Shuttle DTV system.

- Shuttle RMS Inspection Capability (Bottom View)

## Shuttle RMS Inspection Capability (Top View)

- White areas indicate ANALYTICAL resolution is within critical damage size criteria

- Black areas indicate ANALYTICAL resolution is not acceptable

- +

- +

- +

- +

- Note: Black mesh gridlines in white areas are artifacts of mapping program and are within critical damage size criteria.

- +  Area where black mesh gridlines merge on curved surface appear black. Area resolvable within critical damage size criteria.

- Based on imagery captured with a CTVC at max zoom,
- recorded to DVcam digital video tape and downlinked over the Shuttle DTV system.

- Shuttle RMS Inspection Capability (Top View)

## Simple Fixed Boom Installed on Starboard Sill

**Shoulder **
**Transition**
**(EFGF)**

**Elbow**
**Transition**
**(FRGF)**

**Wrist **
**Transition + Sensor(s)**

**Simple Fixed Boom Installed on Starboard Sill**

## Triangular Boom on Starboard Sill

**Shoulder EFGF**

**Elbow FRGF**

**Wrist & Sensors**

## Airbeam Inflatable Boom Concept

## Air Beam Description

- Airbeam Inflatable Boom Concept
# Presentation: 427940

## Slide 1

## High-gradient induction accelerator

**High-gradient induction accelerator**
**G.Caporaso (LLNL) + U Missouri + TPL Corp **

**“****Dielectric-Wall Accelerator” with E = 100MV/m expected due to advanced technologies:**
**  ****High-Gradient Insulators (HGI): E >100MV/m achieved for ******** < 3ns**
**  ****SiC photoconductive switches (27.5MV/m achieved presently, bulk breakdown at >250Mv/m)**
**  ****Cast dielectric with variable ******** (from 3 to 40) by controlled concentration of nano-particles (bulk breakdown at >400MV/m)**
**  ****Zero Integrated Pulse (ZIP) forming line w/o magnetic core**

**HGI**

## Slide 3

## -------------------------------------

**SLIM  **= **SL**AC **I**nduction **M**odule
**DSRD**= **D**rift **S**tep **R**ecovery **D**evice

## The full scale SLIM has not been implemented yet.

**The first in the Western hemisphere solid state DSRD switches will be available from VMI (Visalia, CA) in the beginning of 2008**

## Slide 6