<B><FONT COLOR="#FF0000"><!--SUMMARY_BEGIN-->
<html> <!-- CCP4 HTML LOGFILE -->
<hr>
<!--SUMMARY_END--></FONT></B>

<a name="dmdm"><h1>dm 2.1</h1></a>
<B><FONT COLOR="#FF0000"><!--SUMMARY_BEGIN-->
<pre>
 
 ###############################################################
 ###############################################################
 ###############################################################
 ### CCP4 6.0: dm                 version 6.0       :         ##
 ###############################################################
 User: phzwart  Run date: 20/ 7/2006 Run time: 10:41:03 


 Please reference: Collaborative Computational Project, Number 4. 1994.
 "The CCP4 Suite: Programs for Protein Crystallography". Acta Cryst. D50, 760-763.
 as well as any specific reference in the program write-up.

<!--SUMMARY_END--></FONT></B>
</pre>

<a href="http://www.yorvic.york.ac.uk/~cowtan/dm/refs.html">dm reference:</a>
<blockquote>
K. Cowtan (1994),
  dm: An automated procedure for phase improvement by density modification.
  Joint CCP4 and ESF-EACBM Newsletter on Protein Crystallography, 31, p34-38.
</blockquote><p>


<a name="tocdm"><h2>Contents</h2></a>
<ul>
<li><a href="#commanddm">Command input</a>
<li><a href="#commentsdm">Comments</a>
<li><a href="#mtzindm">MTZ input</a>
<li><a href="#datachkdm">Data Checking</a>
<li><a href="#datascldm">Data Scaling</a>
<li><a href="#solmskdm">Solvent Mask</a>
<li><a href="#cyc0001dm">First Cycle</a>
<li><a href="#dataoutdm">Output</a>
</ul>

<a name="commanddm"><h2>Command Input</h2></a>
<pre>
 Data line--- <a href="/net/sharptail/scratch1/phzwart/ccp4_6.0/test_it/ccp4-6.0/html/dm.html#mode">MODE    </a> SOLV
 Data line--- <a href="/net/sharptail/scratch1/phzwart/ccp4_6.0/test_it/ccp4-6.0/html/dm.html#combine">COMBINE </a> PERT
 Data line--- <a href="/net/sharptail/scratch1/phzwart/ccp4_6.0/test_it/ccp4-6.0/html/dm.html#ncycle">NCYCLE  </a> AUTO
 Data line--- <a href="/net/sharptail/scratch1/phzwart/ccp4_6.0/test_it/ccp4-6.0/html/dm.html#labin">LABIN   </a> FP=FOBS SIGFP=SIGFOBS PHIO=PHMODEL FOMO=FOM
 Data line--- <a href="/net/sharptail/scratch1/phzwart/ccp4_6.0/test_it/ccp4-6.0/html/dm.html#solc">SOLCONT </a> 0.50
</pre>

<a name="commentsdm"><h2>Comments</h2></a>
Density modifications selected:<ul>
<li> Solvent flattening
<li> Histogram matching
</ul>

<h3>Number of cycles</h3>

You have chosen NCYCLE AUTO. This is a cautious mode which
runs few cycles of density modification and terminates at
the first indication of phase bias and FOM overestimation.
This is a good choice when you have weak data and no
averaging. However you must use SCHEME ALL (selected by
default).<p>


<h3>OK, continuing</h3></b>
<pre>

<a name="mtzindm"><h3>MTZ Input</h3></a>

 OPENED INPUT MTZ FILE 
 Logical Name: HKLIN   Filename: hyss.mtz 

 * Title:

 None

 * Base dataset:

        0 HKL_base
          HKL_base
          HKL_base

 * Number of Datasets = 1

 * Dataset ID, project/crystal/dataset names, cell dimensions, wavelength:

        1 project
          crystal
          dataset
             76.8550   76.8550   76.8550   90.0000   90.0000   90.0000
             1.00000

 * Number of Columns = 10

 * Number of Reflections = 5088

 * Missing value set to NaN in input mtz file

 * Column Labels :

 H K L FOBS SIGFOBS FMODEL PHMODEL FOM D CVFLAGS

 * Column Types :

 H H H F Q F P W W I

 * Associated datasets :

 0 0 0 1 1 1 1 1 1 1

 * Cell Dimensions : (obsolete - refer to dataset cell dimensions above)

   76.8550   76.8550   76.8550   90.0000   90.0000   90.0000 

 *  Resolution Range :

    0.00102    0.38228     (     31.373 -      1.617 A )

 * Sort Order :

      0     0     0     0     0

 * Space group = 'I4132' (number     214)


 --- CIF Dictionary loaded ---
Logical name: "MMCIFDIC", full name "/net/sharptail/scratch1/phzwart/ccp4_6.0/test_it/ccp4-6.0/lib/cif_mmdic.lib"
Information from DICTIONARY category:
Title: mmcif_std.dic                    Version: 2.0.09       Datablock id: mmcif_std.dic  




 --- Opening CIF ---
Logical name: "DEPOSITFILE", full name "/net/cci/phzwart/DepositFiles/project/dataset.dm"

 --- CIF opened for output ---
The file has been initialised with no data blocks.



New data block "data_project[dataset]" created for logical unit "DEPOSITFILE"


 Spacegroup information obtained from library file: 
 Logical Name: SYMINFO   Filename: /net/sharptail/scratch1/phzwart/ccp4_6.0/test_it/ccp4-6.0/lib/data/syminfo.lib

 Unit cell volume:  453958.8
 Orthogonalisation matrices:
   76.855   0.000   0.000           0.013   0.000   0.000
    0.000  76.855   0.000           0.000   0.013   0.000
    0.000   0.000  76.855           0.000   0.000   0.013
 Real space metric tensor:      
    5906.7   5906.7   5906.7      0.0      0.0      0.0
 Reciprocal space metric tensor:
  0.000169 0.000169 0.000169 0.000000 0.000000 0.000000

 Grid dimensions   96  96  96  must contain the following prime
 factors for agreement with symmetry restrictions-    4   4   4


 Grid dimensions  144 144 144  must contain the following prime
 factors for agreement with symmetry restrictions-    4   4   4


<a name="datachkdm"><h3>Data Checking</h3></a>

 Number of reflections on file:     5088
 Number outside resolution limit:      0
 Number of systematic absences:        0
 Number outside asymmetric unit:       0
 Number of reflections used:        5088

 Number of unobserved reflections:                     0
 Number of centric reflections:                     1003
 Number of centric phases more than 4 degrees out:     0

 Program data read:
 Column:      MIN       MAX       MEAN X    MEAN X^2
    H          0.000    26.000     7.252      85.226
    K          2.000    47.000    29.102     923.297
    L          0.000    33.000    15.962     308.309
    S          0.001     0.382     0.223       0.060
    EPS       -8.000     2.000     1.176       4.285
    FO         0.447   308.204    28.399    2281.840
    PHIO      -3.142     3.142     0.050       3.335
    FOMO       0.000     1.000     0.200       0.095
    HL-A     -54.000    54.000     0.020       2.454
    HL-B     -54.000    54.000    -0.030       3.109
    HL-C       0.000     0.000     0.000       0.000
    HL-D       0.000     0.000     0.000       0.000

<a name="datascldm"><h3>Data Scaling</h3></a>

 Input data analysis:
   Estimated intensity scale factor =     32.775
   Estimated temperature factor     =     26.917

<applet width=" 400" height=" 300" code="JLogGraph.class" 
codebase="/net/sharptail/scratch1/phzwart/ccp4_6.0/test_it/ccp4-6.0/bin"><param name="table" value="
 $TABLE: Analysis of input structure factors :
 $GRAPHS: Data completeness with resolution :N:2,4:
        : Mean F^2 with resolution          :N:2,5,6:
 $$
  res   1/resol^2  number    %present      expect.   obs. $$
 (lim)(4sin2th/l2)(reflns) (completeness)    (mean F^2)   $$
 10.00   0.006        32.        91.4    380374.  253913.
  8.00   0.013        27.       100.0    248069.  136219.
  7.00   0.018        26.       100.0    144949.  286642.
  6.00   0.024        46.       100.0    149071.  119935.
  5.00   0.034        85.       100.0    271565.  280721.
  4.50   0.045        70.       100.0    362698.  387624.
  4.00   0.056       109.       100.0    415419.  520424.
  3.60   0.070       139.       100.0    346290.  437469.
  3.30   0.085       148.       100.0    332690.  481623.
  3.00   0.102       213.       100.0    245261.  520567.
  2.80   0.119       186.       100.0    225772.  236044.
  2.60   0.138       253.        99.6    197830.  131484.
  2.40   0.161       334.        98.8    188965.  123014.
  2.20   0.190       476.        99.2    169511.  110191.
  2.00   0.229       670.        98.5    152458.  110521.
  1.80   0.280       967.        97.1    115654.  103166.
  1.60   0.345      1307.        83.9     82912.  127152.
 $$
"><b>For inline graphs use a Java browser</b></applet>

FORMATTED      OLD     file opened on unit   8
<B><FONT COLOR="#FF0000"><!--SUMMARY_BEGIN-->
Logical name: HISTLIB, Filename: /net/sharptail/scratch1/phzwart/ccp4_6.0/test_it/ccp4-6.0/lib/data/hist.lib
<!--SUMMARY_END--></FONT></B>


 HISTLIB opened:
  Number of histograms            =   18
  Number of entries per histogram =  100
 RESL  10.0  8.0  7.0  6.0  5.0  4.5  4.0  3.6  3.3  3.0  2.8  2.6  2.4  2.2  2.0  1.8  1.6  1.5


<a name="solmskdm"><h3>Initial Solvent Mask</h3></a>

 Auto Wang-radius    7.1

            The masked region occupies  50.0 % of the cell.
            Maps are x-y sections with the x-axis horizontal
            and the origin top left.

 Section   0 of  96

 *****+++++++*********++++++******************+++++++************        
 *******  **************   ******************         ***********        
 *******  ******   ******  *****************          ***********        
 ***************   *************************           **********        
 +  **********      **********    *********             ********+        
 +    *********     *********       ********           ******** +        
 +       ******     ******          *******             ******  +        
 +        *****     ****             ******             ******  +        
 +                                   *****              ******  +        
 +                                  ******              ******* +        
 ***                           **** ****                   ***  *        
 ***                          ******          *******          **        
 ***           *****          ******          *******         ***        
 ***          ******          ******          ******          ***        
 ***          *******          *****            ***           ***        
 ***                           *****                           **        
 ** ****                  ***** ***                             *        
 +  ******              ******                                  +        
 +   *****              ******                                  +        
 +   ******             ******            ******   ******       +        
 +  ********           ********         *******     *******     +        
 +  ********           ********       *********     *********   +        
 ***********           *********** ***********      ************+        
 ***********          ****************** *******   ******* ******        
 ***********          ******************  ******  *******  ******        
 ************         *****************    *************    *****        
 *************       *****************        ******        *****        
 *************      ******************          **           ****        
 **************     ****************                          ***        
 **************     ****************                          ***        
 **************     ****************                           **        
 *************       ***************                           **        
 *************       ****************                         ***        
 *************      ********************  **           *  ** ****        
 *************      ***************** ******           *****  ***        
 *************      ************************           **********        
 +  **********       *********       *******          ********  +        
 +   *********       *********       *******          ********  +        
 +    *******         *******         ******          *******   +        
 +    ******          *******         *******         *******   +        
 +   *******          ********       *********       *********  +        
 +  ********           *******     ***********       ***********+        
 **** ******           ****** ****************      *************        
 **** ******           *****  ****************      *************        
 *****                       *****************      *************        
 ****                         ****************       ************        
 ***                           ***************       ************        
 ***                           ****************     *************        
 ***                          *****************     *************        
 ****                         ****************      *************        
 *****++++++++++***+++++++++******************++++++*************        

 INPUT DATA IDENTIFIED: Data appears to have good FOMs at low
 resolution and poor FOMs at high resolution. Calculation
 will be phase extension by resolution.
 Approximate resolution cutoff for starting data:   3.013 A
 Approximate number of starting reflections     786 of    5088
<applet width=" 400" height=" 300" code="JLogGraph.class" 
codebase="/net/sharptail/scratch1/phzwart/ccp4_6.0/test_it/ccp4-6.0/bin"><param name="table" value="
 $TABLE: Analysis of input figures of merit :
 $GRAPHS: Mean FOM with resolution :N:2,4:
 $$
  res   1/resol^2  number   mean_FOM$$
 (lim)(4sin2th/l2)(reflns) $$
 12.42   0.006        18.     0.458
  8.78   0.013        29.     0.532
  7.17   0.019        33.     0.432
  6.21   0.026        39.     0.557
  5.56   0.032        38.     0.472
  5.07   0.039        46.     0.563
  4.70   0.045        52.     0.580
  4.39   0.052        55.     0.631
  4.14   0.058        53.     0.567
  3.93   0.065        53.     0.623
  3.75   0.071        61.     0.557
  3.59   0.078        67.     0.482
  3.45   0.084        58.     0.540
  3.32   0.091        67.     0.478
  3.21   0.097        67.     0.494
  3.11   0.104        73.     0.489
  3.01   0.110        75.     0.397
  2.93   0.117        71.     0.303
  2.85   0.123        76.     0.236
  2.78   0.130        70.     0.199
  2.71   0.136        84.     0.131
  2.65   0.143        77.     0.132
  2.59   0.149        85.     0.109
  2.54   0.156        88.     0.157
  2.48   0.162        81.     0.228
  2.44   0.168        89.     0.183
  2.39   0.175        84.     0.165
  2.35   0.181        96.     0.152
  2.31   0.188        89.     0.123
  2.27   0.194        89.     0.110
  2.23   0.201        95.     0.115
  2.20   0.207        96.     0.093
  2.16   0.214        99.     0.077
  2.13   0.220        95.     0.072
  2.10   0.227        99.     0.067
  2.07   0.233        98.     0.050
  2.04   0.240       107.     0.063
  2.02   0.246       102.     0.280
  1.99   0.253       101.     0.292
  1.96   0.259       107.     0.230
  1.94   0.266       101.     0.183
  1.92   0.272       111.     0.188
  1.89   0.279        99.     0.165
  1.87   0.285       108.     0.174
  1.85   0.292       117.     0.124
  1.83   0.298       104.     0.105
  1.81   0.305       113.     0.086
  1.79   0.311       111.     0.068
  1.77   0.317       115.     0.091
  1.76   0.324       106.     0.156
  1.74   0.330       121.     0.137
  1.72   0.337       118.     0.139
  1.71   0.343       112.     0.107
  1.69   0.350       127.     0.110
  1.68   0.356       109.     0.092
  1.66   0.363       116.     0.078
  1.65   0.369       121.     0.061
  1.63   0.376       113.     0.061
  1.62   0.382       100.     0.044
 $$
"><b>For inline graphs use a Java browser</b></applet>

 Weights for including reflections
        by magnitude:  1.00
        by FOM:        1.00
        by resolution: 2.00

<hr>
</pre>

<a name="cyc0001dm"><h3>Cycle    1</h3></a>
<a href="#cyc0002dm">Next cycle</a>
<a href="#tocdm">Contents</a>
<pre>

  Effective resolution:  1.617 A
  Number of reflections included:    5088
  Number of reflections excluded:       0

 REAL/FREE protein sphere at   48.034   9.607   9.607 remoteness    6.633

 REAL/FREE solvent sphere at   12.809  24.017   5.604 remoteness   -6.301

 REAL/FREE-R MASKS:
   1.00 of free solvent sphere lies in solvent
   1.00 of free protein sphere lies in protein


*************************************************
* Solvent Resid :  0.313 FreeSol Resid :  0.262 *
* Protein Resid :  0.475 FreePrt Resid :  0.473 *
* Combine Resid :  0.394 FreeCmb Resid :  0.367 *
*************************************************


         % of cell   Min Rho   Max Rho   Mean Rho   Std.Dev.
 Protein:     50.0    -0.518     2.842      0.389      0.353
 Solvent:     50.0    -0.412     2.621      0.361      0.310

 Density       Number of counts:   Number of counts:
 Range:        (Protein)           (Solvent)
   -0.875                 0                   0
   -0.625                24                   0
   -0.375              1648                 912
   -0.125             30088               26400
    0.125            132312              142232
    0.375            159752              172012
    0.625             69992               65008
    0.875             22040               17200
    1.125             11232                8208
    1.375              6920                5048
    1.625              4208                2712
    1.875              2616                1848
    2.125              1224                 576
    2.375               192                 116


 HISTOGRAM MAPPING:
  Fcalc histograms chosen: resolution = 1.80 1.60 A
                              weights = 0.09 0.91
  Fcalc mean,std   0.435  0.819  Adjusted mean,std   0.434  0.816

    RHO       Counts    Counts       
              (Desired) (Transformed)

    -0.975     0.000759  0.000633
    -0.571     0.003672  0.003689
    -0.167     0.033548  0.034720
     0.237     0.056405  0.056999
     0.641     0.010270  0.010308
     1.045     0.005712  0.005859
     1.449     0.004444  0.004394
     1.854     0.003479  0.003472
     2.258     0.003115  0.003038
     2.662     0.002153  0.002116
     3.066     0.001335  0.001302
     3.470     0.000805  0.000977
     3.874     0.000466  0.000488

         % of cell   Min Rho   Max Rho   Mean Rho   Std.Dev.
 Protein:     50.0    -0.996     4.000      0.434      0.816
 Solvent:     50.0     0.320     0.320      0.320      0.000

 Density       Number of counts:   Number of counts:
 Range:        (Protein)           (Solvent)
   -0.875              1480                   0
   -0.625              6928                   0
   -0.375             28728                   0
   -0.125             86040                   0
    0.125            129896                   0
    0.375             77088              442344
    0.625             26176                   0
    0.875             15640                   0
    1.125             11808                   0
    1.375              9648                   0
    1.625              9600                   0
    1.875              7944                   0
    2.125              7160                   0
    2.375              6168                   0


         % of cell   Min Rho   Max Rho   Mean Rho   Std.Dev.
 Protein:     50.0    -0.529     2.864      0.390      0.357
 Solvent:     50.0    -0.476     2.556      0.360      0.314

 Density       Number of counts:   Number of counts:
 Range:        (Protein)           (Solvent)
   -0.875                 0                   0
   -0.625                48                   0
   -0.375              2224                2024
   -0.125             31912               27528
    0.125            130634              141132
    0.375            156142              168352
    0.625             71296               66064
    0.875             23200               18520
    1.125             11800                8184
    1.375              6752                5384
    1.625              4256                2640
    1.875              2496                1656
    2.125              1248                 672
    2.375               336                 140


 HISTOGRAM MAPPING:
  Fcalc histograms chosen: resolution = 1.80 1.60 A
                              weights = 0.09 0.91
  Fcalc mean,std   0.435  0.819  Adjusted mean,std   0.434  0.815

    RHO       Counts    Counts       
              (Desired) (Transformed)

    -0.975     0.000759  0.000543
    -0.571     0.003672  0.004123
    -0.167     0.033548  0.034015
     0.237     0.056405  0.054685
     0.641     0.010270  0.011772
     1.045     0.005712  0.005968
     1.449     0.004444  0.004991
     1.854     0.003479  0.002713
     2.258     0.003115  0.002930
     2.662     0.002153  0.002279
     3.066     0.001335  0.001736
     3.470     0.000805  0.001085
     3.874     0.000466  0.000543

 Perturbation gamma correction:
    Resolution    Gamma
        1.62      0.9893
  Overall value   0.9893

 Sigma-a refinement: 11 cycles.
 Phase combination statistics:
  Number of reflections included in phase recombination =    5088

 RMIN - RMAX    S^2   NREFLS  SIGMAA   MEAN FOM  MEAN FOM  MEAN FOM  MEAN DPHI  MEAN DPHI  MEAN DPHI
                                        (obs.)    (calc)    (comb)   |obs-cal|  |obs-com|  |cal-com|
 100.00  3.68  0.074   503.    0.3453    0.556     0.248     0.580       76.5       15.3       61.3
   3.68  2.88  0.121   504.    0.4596    0.427     0.348     0.509       71.0       29.4       41.7
   2.88  2.49  0.161   501.    0.2223    0.157     0.170     0.242       75.6       41.0       34.6
   2.49  2.25  0.197   507.    0.1662    0.145     0.125     0.202       75.7       34.8       40.9
   2.25  2.08  0.232   502.    0.2120    0.075     0.167     0.191       77.5       55.8       21.7
   2.08  1.95  0.263   504.    0.0011    0.202     0.001     0.202       78.4        0.3       78.1
   1.95  1.84  0.294   509.    0.0000    0.160     0.000     0.160       85.1        0.4       84.8
   1.84  1.76  0.323   503.    0.0000    0.098     0.000     0.098       86.4        0.2       86.2
   1.76  1.69  0.351   510.    0.1836    0.125     0.144     0.178       96.0       55.9       40.1
   1.69  1.62  0.382   545.    0.1714    0.066     0.132     0.140       96.6       70.7       25.9
<hr>
</pre>

<a name="cyc0002dm"><h3>Cycle    2</h3></a>
<a href="#cyc0003dm">Next cycle</a>
<a href="#tocdm">Contents</a>
<pre>

  Effective resolution:  1.617 A
  Number of reflections included:    5088
  Number of reflections excluded:       0

 Auto Wang-radius    6.6

            The masked region occupies  50.0 % of the cell.
            Maps are x-y sections with the x-axis horizontal
            and the origin top left.

 Section   0 of  96

 *****++++++**********+++++++*****************+++++++************        
 *****      ***********     *****************         ***********        
 *****    **************    *****************         ***********        
 ***      ******  *******      *************          ***********        
 +        ****      *****         **********           *********+        
 +        ****      *****          *********           *********+        
 +        ****      *****           *******             ******* +        
 +                                  ******              ******  +        
 +                                  ******              ******  +        
 *                               *******                   ******        
 ***                           *******                      *****        
 ***           *****           ******          *****          ***        
 ***          ******          *******         *******         ***        
 ****         *******         *******         *******         ***        
 ****         ******          ******          ******          ***        
 *****                       *******           *****           **        
 ******                     *******                             *        
 +  ******               ******                                 +        
 +  ******              ******                                  +        
 +  *******             ******            ****       ***        +        
 +  ********           ********           ****      *****       +        
 + *********           *********          ****      *****       +        
 +**********          ***********         *****     *****       +        
 ***********          ****************    ******* *******    ****        
 ************         ****************     *************    *****        
 *************       *****************      **********      *****        
 *************       *****************       *********       ****        
 *************       *****************          ***          ****        
 *************      *****************                         ***        
 *************      ****************                          ***        
 *************      ****************                          ***        
 **************     ****************                          ***        
 **************     ****************                          ***        
 **************     *****************   ****           ***    ***        
 *************      ***************** ******          ******* ***        
 *************       *************   *******          ********  *        
 +  **********       **********      ********         ********  +        
 +  **********       *********        *******         *******   +        
 +    *******         *******         *******         *******   +        
 +    *******         *******         *******         *******   +        
 +    *******         *******       **********       *********  +        
 +   *******          ********    ************       ***********+        
 ***********          ************************      *************        
 ****  *****          ******  *****************     *************        
 ****                         *****************     *************        
 ***                          *****************     *************        
 ***                          *****************     *************        
 ***                          ****************      *************        
 ***                          ****************      *************        
 *****                       *****************      *************        
 *****++++++++*******++++++++*****************+++++++************        

 REAL/FREE-R MASKS:
   1.00 of free solvent sphere lies in solvent
   1.00 of free protein sphere lies in protein


*************************************************
* Solvent Resid :  0.261 FreeSol Resid :  0.213 *
* Protein Resid :  0.395 FreePrt Resid :  0.386 *
* Combine Resid :  0.328 FreeCmb Resid :  0.299 *
*************************************************


         % of cell   Min Rho   Max Rho   Mean Rho   Std.Dev.
 Protein:     50.0    -0.781     3.405      0.391      0.435
 Solvent:     50.0    -0.371     2.420      0.359      0.259

 Density       Number of counts:   Number of counts:
 Range:        (Protein)           (Solvent)
   -0.875                24                   0
   -0.625               480                   0
   -0.375              7112                 552
   -0.125             47752               15984
    0.125            130272              140872
    0.375            133496              187516
    0.625             61384               68600
    0.875             24528               17088
    1.125             13896                6592
    1.375              9040                3336
    1.625              6040                1128
    1.875              3640                 420
    2.125              2344                 240
    2.375              1560                  48


 HISTOGRAM MAPPING:
  Fcalc histograms chosen: resolution = 1.80 1.60 A
                              weights = 0.09 0.91
  Fcalc mean,std   0.435  0.819  Adjusted mean,std   0.434  0.816

    RHO       Counts    Counts       
              (Desired) (Transformed)

    -0.975     0.000759  0.000543
    -0.571     0.003672  0.004539
    -0.167     0.033548  0.033095
     0.237     0.056405  0.052681
     0.641     0.010270  0.010670
     1.045     0.005712  0.005317
     1.449     0.004444  0.004340
     1.854     0.003479  0.003472
     2.258     0.003115  0.003255
     2.662     0.002153  0.002821
     3.066     0.001335  0.001085
     3.470     0.000805  0.001085
     3.874     0.000466  0.000434

         % of cell   Min Rho   Max Rho   Mean Rho   Std.Dev.
 Protein:     50.0    -0.996     4.000      0.434      0.816
 Solvent:     50.0     0.320     0.320      0.320      0.000

 Density       Number of counts:   Number of counts:
 Range:        (Protein)           (Solvent)
   -0.875              1680                   0
   -0.625              6344                   0
   -0.375             28872                   0
   -0.125             86800                   0
    0.125            128224                   0
    0.375             78472              442376
    0.625             26224                   0
    0.875             15072                   0
    1.125             12072                   0
    1.375             10008                   0
    1.625              9216                   0
    1.875              7944                   0
    2.125              7056                   0
    2.375              6184                   0


         % of cell   Min Rho   Max Rho   Mean Rho   Std.Dev.
 Protein:     50.0    -0.695     3.378      0.391      0.439
 Solvent:     50.0    -0.424     2.404      0.359      0.266

 Density       Number of counts:   Number of counts:
 Range:        (Protein)           (Solvent)
   -0.875                 0                   0
   -0.625               768                   0
   -0.375              7376                 712
   -0.125             50392               19648
    0.125            125744              138672
    0.375            132926              182006
    0.625             62810               71310
    0.875             25008               18448
    1.125             13680                6360
    1.375              9448                3504
    1.625              5488                1008
    1.875              3880                 360
    2.125              2472                 300
    2.375              1624                  48


 HISTOGRAM MAPPING:
  Fcalc histograms chosen: resolution = 1.80 1.60 A
                              weights = 0.09 0.91
  Fcalc mean,std   0.435  0.819  Adjusted mean,std   0.434  0.816

    RHO       Counts    Counts       
              (Desired) (Transformed)

    -0.975     0.000759  0.000705
    -0.571     0.003672  0.003798
    -0.167     0.033548  0.036350
     0.237     0.056405  0.055493
     0.641     0.010270  0.011647
     1.045     0.005712  0.005751
     1.449     0.004444  0.003472
     1.854     0.003479  0.003364
     2.258     0.003115  0.003364
     2.662     0.002153  0.001736
     3.066     0.001335  0.001610
     3.470     0.000805  0.000868
     3.874     0.000466  0.000760

 Perturbation gamma correction:
    Resolution    Gamma
        1.62      0.7755
  Overall value   0.7755

 Sigma-a refinement:  3 cycles.
 Phase combination statistics:
  Number of reflections included in phase recombination =    5088

 RMIN - RMAX    S^2   NREFLS  SIGMAA   MEAN FOM  MEAN FOM  MEAN FOM  MEAN DPHI  MEAN DPHI  MEAN DPHI
                                        (obs.)    (calc)    (comb)   |obs-cal|  |obs-com|  |cal-com|
 100.00  3.68  0.074   503.    0.4873    0.556     0.355     0.607       67.9       18.7       49.3
   3.68  2.88  0.121   504.    0.5917    0.427     0.447     0.571       59.9       30.1       29.8
   2.88  2.49  0.161   501.    0.3205    0.157     0.245     0.309       66.9       45.4       21.5
   2.49  2.25  0.197   507.    0.3141    0.145     0.235     0.295       70.4       45.3       25.1
   2.25  2.08  0.232   502.    0.3592    0.075     0.281     0.302       71.5       59.6       11.9
   2.08  1.95  0.263   504.    0.2534    0.202     0.195     0.298       73.8       40.2       33.6
   1.95  1.84  0.294   509.    0.1223    0.160     0.093     0.197       80.0       27.4       52.6
   1.84  1.76  0.323   503.    0.1877    0.098     0.145     0.185       76.5       50.2       26.3
   1.76  1.69  0.351   510.    0.4043    0.125     0.320     0.337       86.3       69.1       17.3
   1.69  1.62  0.382   545.    0.4105    0.066     0.312     0.314       92.6       81.8       10.8
<hr>
</pre>

<a name="cyc0003dm"><h3>Cycle    3</h3></a>
<a href="#cyc0004dm">Next cycle</a>
<a href="#tocdm">Contents</a>
<pre>

  Effective resolution:  1.617 A
  Number of reflections included:    5088
  Number of reflections excluded:       0

 Auto Wang-radius    5.7

            The masked region occupies  50.0 % of the cell.
            Maps are x-y sections with the x-axis horizontal
            and the origin top left.

 Section   0 of  96

 *****++++++**********+++++++*****************+++++++************        
 *****      **********       *****************       ************        
 ****       ***********       ***************         ***********        
 *         *****   *****        ************          ***********        
 +        ****      ****          **********          **********+        
 +        ****       ***           *********          **********+        
 +         **         **            ********           *******  +        
 +                                  *******             ******  +        
 +                                  ******              ******* +        
 *                              *******                     *****        
 ***           *****           ********                     *****        
 ***          ******          ********          ***          ****        
 ****         *******         *******         *******         ***        
 ****         *******         *******         *******         ***        
 ****         ******          ******          ******          ***        
 *****                      ********           *****           **        
 ******                     *******                             *        
 + *******               *******                                +        
 +  *******             ******                                  +        
 +  ********           *******                                  +        
 +  ********           ********           ****       ***        +        
 + *********          **********          ****       ***        +        
 +**********          ***********         *****     ****        +        
 ***********          **************       *************      ***        
 ************         ***************       ***********       ***        
 *************       *****************      **********       ****        
 *************       *****************      **********       ****        
 *************      ******************        ******         ****        
 *************      *****************                         ***        
 *************      *****************                         ***        
 **************     ****************                          ***        
 **************     ****************                          ***        
 **************     ****************                          ***        
 **************     ****************    ****           ***    ***        
 *************      **************** *******          ***********        
 *************       *************   ********         ********  *        
 +  **********       **********       *******         *******   +        
 +  **********       *********        *******         *******   +        
 +    *******         *******         ******          ******    +        
 +    ******          ******          *******         *******   +        
 +    *******         *******       **********       *********  +        
 +    *******         *******     ************       ************        
 **  *******          ********  **************      *************        
 ***   *****          ******  *****************     *************        
 ***     **             **    *****************     *************        
 ***                          *****************     *************        
 ***                          *****************     *************        
 ***                          *****************     *************        
 ****                         ****************      *************        
 *****                       *****************      *************        
 *****+++++++*********+++++++*****************+++++++************        

 REAL/FREE-R MASKS:
   1.00 of free solvent sphere lies in solvent
   1.00 of free protein sphere lies in protein


*************************************************
* Solvent Resid :  0.265 FreeSol Resid :  0.216 *
* Protein Resid :  0.328 FreePrt Resid :  0.310 *
* Combine Resid :  0.297 FreeCmb Resid :  0.263 *
*************************************************


         % of cell   Min Rho   Max Rho   Mean Rho   Std.Dev.
 Protein:     50.0    -0.818     3.762      0.391      0.507
 Solvent:     50.0    -0.468     3.272      0.359      0.263

 Density       Number of counts:   Number of counts:
 Range:        (Protein)           (Solvent)
   -0.875               144                   0
   -0.625              1984                   0
   -0.375             14272                1080
   -0.125             58936               21192
    0.125            124026              131424
    0.375            114470              186576
    0.625             57424               72756
    0.875             26304               18328
    1.125             15120                6760
    1.375             10096                2976
    1.625              6792                 864
    1.875              5128                 120
    2.125              2872                 156
    2.375              2112                  96


 HISTOGRAM MAPPING:
  Fcalc histograms chosen: resolution = 1.80 1.60 A
                              weights = 0.09 0.91
  Fcalc mean,std   0.435  0.819  Adjusted mean,std   0.434  0.816

    RHO       Counts    Counts       
              (Desired) (Transformed)

    -0.975     0.000759  0.000904
    -0.571     0.003672  0.003364
    -0.167     0.033548  0.033149
     0.237     0.056405  0.053820
     0.641     0.010270  0.010091
     1.045     0.005712  0.006022
     1.449     0.004444  0.004015
     1.854     0.003479  0.003798
     2.258     0.003115  0.003906
     2.662     0.002153  0.002713
     3.066     0.001335  0.001519
     3.470     0.000805  0.000760
     3.874     0.000466  0.000651

         % of cell   Min Rho   Max Rho   Mean Rho   Std.Dev.
 Protein:     50.0    -0.993     4.000      0.434      0.816
 Solvent:     50.0     0.320     0.320      0.320      0.000

 Density       Number of counts:   Number of counts:
 Range:        (Protein)           (Solvent)
   -0.875              1624                   0
   -0.625              6520                   0
   -0.375             28360                   0
   -0.125             86536                   0
    0.125            128224                   0
    0.375             79096              442376
    0.625             26352                   0
    0.875             14928                   0
    1.125             11712                   0
    1.375             10512                   0
    1.625              8976                   0
    1.875              7968                   0
    2.125              7152                   0
    2.375              6424                   0


         % of cell   Min Rho   Max Rho   Mean Rho   Std.Dev.
 Protein:     50.0    -0.870     3.758      0.390      0.511
 Solvent:     50.0    -0.504     3.238      0.360      0.270

 Density       Number of counts:   Number of counts:
 Range:        (Protein)           (Solvent)
   -0.875               144                   0
   -0.625              2672                  48
   -0.375             14608                1216
   -0.125             60592               23992
    0.125            122472              131576
    0.375            110600              179276
    0.625             58824               75256
    0.875             27024               19632
    1.125             15288                7192
    1.375             10888                2760
    1.625              6936                 864
    1.875              4456                 264
    2.125              3208                 144
    2.375              2088                  60


 HISTOGRAM MAPPING:
  Fcalc histograms chosen: resolution = 1.80 1.60 A
                              weights = 0.09 0.91
  Fcalc mean,std   0.435  0.819  Adjusted mean,std   0.434  0.816

    RHO       Counts    Counts       
              (Desired) (Transformed)

    -0.975     0.000759  0.000651
    -0.571     0.003672  0.003744
    -0.167     0.033548  0.033294
     0.237     0.056405  0.055936
     0.641     0.010270  0.010037
     1.045     0.005712  0.006131
     1.449     0.004444  0.004774
     1.854     0.003479  0.003798
     2.258     0.003115  0.002279
     2.662     0.002153  0.001736
     3.066     0.001335  0.001845
     3.470     0.000805  0.000904
     3.874     0.000466  0.000543

 Perturbation gamma correction:
    Resolution    Gamma
        1.62      0.6407
  Overall value   0.6407

 Sigma-a refinement:  3 cycles.
 Phase combination statistics:
  Number of reflections included in phase recombination =    5088

 RMIN - RMAX    S^2   NREFLS  SIGMAA   MEAN FOM  MEAN FOM  MEAN FOM  MEAN DPHI  MEAN DPHI  MEAN DPHI
                                        (obs.)    (calc)    (comb)   |obs-cal|  |obs-com|  |cal-com|
 100.00  3.68  0.074   503.    0.5384    0.556     0.397     0.617       63.9       19.6       44.3
   3.68  2.88  0.121   504.    0.6835    0.427     0.532     0.613       58.2       35.3       23.0
   2.88  2.49  0.161   501.    0.4567    0.157     0.355     0.398       65.7       49.6       16.1
   2.49  2.25  0.197   507.    0.5670    0.145     0.444     0.472       67.0       53.1       14.0
   2.25  2.08  0.232   502.    0.5686    0.075     0.449     0.459       72.5       66.1        6.4
   2.08  1.95  0.263   504.    0.5265    0.202     0.409     0.459       66.1       50.2       15.9
   1.95  1.84  0.294   509.    0.4302    0.160     0.329     0.372       73.7       54.8       19.0
   1.84  1.76  0.323   503.    0.4417    0.098     0.345     0.363       74.0       61.6       12.5
   1.76  1.69  0.351   510.    0.6036    0.125     0.463     0.468       83.4       74.1        9.3
   1.69  1.62  0.382   545.    0.5968    0.066     0.445     0.447       88.4       82.5        5.9
<hr>
</pre>

<a name="cyc0004dm"><h3>Cycle    4</h3></a>
<a href="#cyc0005dm">Next cycle</a>
<a href="#tocdm">Contents</a>
<pre>

  Effective resolution:  1.617 A
  Number of reflections included:    5088
  Number of reflections excluded:       0

 Auto Wang-radius    4.9

            The masked region occupies  50.0 % of the cell.
            Maps are x-y sections with the x-axis horizontal
            and the origin top left.

 Section   0 of  96

 *****++++++**********+++++++*****************+++++++************        
 *****      **********       *****************       ************        
 ***        **********        ***************         ***********        
 *          ****** ***          ************          ***********        
 +          **       *            **********          **********+        
 +          *                      *********          **********+        
 +                                  ********           *******  +        
 +                                  ********           *******  +        
 +                                  ******              ******* +        
 *                               ********                 *******        
 ***           *****           *******                      *****        
 ***          ******          ********         *****         ****        
 ***          ******          *******         ******          ***        
 ***          ******          ******          ******          ***        
 *****        ******         *******          ******          ***        
 *****                      ********          ******           **        
 *****                      *******              *              *        
 +  ******               ******                                 +        
 +  *******             ******                                  +        
 +  ********           *******                                  +        
 +  ********           ********                                 +        
 + *********          **********            *                   +        
 +**********          ***********           **      **          +        
 ************         **************        **********         **        
 *************       ****************       **********        ***        
 *************       *****************      **********       ****        
 *************       *****************       *********       ****        
 *************       ****************         *******         ***        
 *************      *****************                         ***        
 *************      *****************                         ***        
 **************     ****************                          ***        
 ***************   *****************                          ***        
 ***************   *****************     **             **     **        
 **************     ****************    ****           ****   ***        
 *************      **************** *******          ***********        
 *************       *************   ********         ********  *        
 +  **********       **********       *******         *******   +        
 +   ********         ********        *******         ******    +        
 +    *******         *******         ******          ******    +        
 +    ******          ******          *******         *******   +        
 +    *******         ******         ********         ********  +        
 +    *******         *******     ************       ***********+        
 *** *******          ******** ***************      *************        
 ***  ******          ******  *****************     *************        
 ***    ***             **     *****************   **************        
 ***     **             **     *****************   **************        
 ***                          ******************   **************        
 ***                          *****************     *************        
 ****                         ****************      *************        
 ****                         ****************      *************        
 *****+++++++*********+++++++*****************+++++++************        

 REAL/FREE-R MASKS:
   1.00 of free solvent sphere lies in solvent
   1.00 of free protein sphere lies in protein


*************************************************
* Solvent Resid :  0.260 FreeSol Resid :  0.214 *
* Protein Resid :  0.251 FreePrt Resid :  0.221 *
* Combine Resid :  0.256 FreeCmb Resid :  0.217 *
*************************************************


         % of cell   Min Rho   Max Rho   Mean Rho   Std.Dev.
 Protein:     50.0    -1.236     3.930      0.394      0.594
 Solvent:     50.0    -0.518     2.917      0.356      0.258

 Density       Number of counts:   Number of counts:
 Range:        (Protein)           (Solvent)
   -0.875               816                   0
   -0.625              5632                  48
   -0.375             24792                1320
   -0.125             66472               24624
    0.125            113768              130136
    0.375             95952              177308
    0.625             54360               79336
    0.875             26032               20976
    1.125             16704                6072
    1.375             12072                1584
    1.625              8176                 640
    1.875              5880                  60
    2.125              4080                  48
    2.375              2656                   0


 HISTOGRAM MAPPING:
  Fcalc histograms chosen: resolution = 1.80 1.60 A
                              weights = 0.09 0.91
  Fcalc mean,std   0.435  0.819  Adjusted mean,std   0.434  0.815

    RHO       Counts    Counts       
              (Desired) (Transformed)

    -0.975     0.000759  0.000687
    -0.571     0.003672  0.003688
    -0.167     0.033548  0.033082
     0.237     0.056405  0.056023
     0.641     0.010270  0.010738
     1.045     0.005712  0.006833
     1.449     0.004444  0.004122
     1.854     0.003479  0.003254
     2.258     0.003115  0.003091
     2.662     0.002153  0.001844
     3.066     0.001335  0.001627
     3.470     0.000805  0.000868
     3.874     0.000466  0.000813

         % of cell   Min Rho   Max Rho   Mean Rho   Std.Dev.
 Protein:     50.0    -0.998     4.000      0.434      0.815
 Solvent:     50.0     0.320     0.320      0.320      0.000

 Density       Number of counts:   Number of counts:
 Range:        (Protein)           (Solvent)
   -0.875              1424                   0
   -0.625              6600                   0
   -0.375             28920                   0
   -0.125             86459                   0
    0.125            129253                   0
    0.375             77832              442200
    0.625             26376                   0
    0.875             14832                   0
    1.125             12136                   0
    1.375             10176                   0
    1.625              9096                   0
    1.875              8112                   0
    2.125              7032                   0
    2.375              6160                   0


         % of cell   Min Rho   Max Rho   Mean Rho   Std.Dev.
 Protein:     50.0    -1.363     3.913      0.393      0.597
 Solvent:     50.0    -0.581     2.928      0.357      0.265

 Density       Number of counts:   Number of counts:
 Range:        (Protein)           (Solvent)
   -0.875               952                   0
   -0.625              6120                  96
   -0.375             25728                1464
   -0.125             68408               26720
    0.125            109072              129400
    0.375             97476              171556
    0.625             52452               82320
    0.875             27664               21552
    1.125             16416                6616
    1.375             11976                1656
    1.625              8560                 640
    1.875              5784                 132
    2.125              3912                   0
    2.375              2776                   0


 HISTOGRAM MAPPING:
  Fcalc histograms chosen: resolution = 1.80 1.60 A
                              weights = 0.09 0.91
  Fcalc mean,std   0.435  0.819  Adjusted mean,std   0.433  0.816

    RHO       Counts    Counts       
              (Desired) (Transformed)

    -0.975     0.000759  0.000741
    -0.571     0.003672  0.002603
    -0.167     0.033548  0.032485
     0.237     0.056405  0.052931
     0.641     0.010270  0.009545
     1.045     0.005712  0.007050
     1.449     0.004444  0.004772
     1.854     0.003479  0.003688
     2.258     0.003115  0.003471
     2.662     0.002153  0.002278
     3.066     0.001335  0.001410
     3.470     0.000805  0.000542
     3.874     0.000466  0.000759

 Perturbation gamma correction:
    Resolution    Gamma
        1.62      0.5653
  Overall value   0.5653

 Sigma-a refinement:  3 cycles.
 Phase combination statistics:
  Number of reflections included in phase recombination =    5088

 RMIN - RMAX    S^2   NREFLS  SIGMAA   MEAN FOM  MEAN FOM  MEAN FOM  MEAN DPHI  MEAN DPHI  MEAN DPHI
                                        (obs.)    (calc)    (comb)   |obs-cal|  |obs-com|  |cal-com|
 100.00  3.68  0.074   503.    0.5401    0.556     0.401     0.619       63.7       20.7       43.1
   3.68  2.88  0.121   504.    0.7252    0.427     0.570     0.639       55.3       36.7       18.6
   2.88  2.49  0.161   501.    0.5642    0.157     0.447     0.481       61.3       50.8       10.5
   2.49  2.25  0.197   507.    0.6576    0.145     0.529     0.550       62.1       53.1        9.0
   2.25  2.08  0.232   502.    0.6516    0.075     0.521     0.530       68.4       62.4        6.0
   2.08  1.95  0.263   504.    0.6534    0.202     0.525     0.551       66.5       55.7       10.8
   1.95  1.84  0.294   509.    0.5848    0.160     0.451     0.477       71.4       59.9       11.5
   1.84  1.76  0.323   503.    0.5231    0.098     0.412     0.425       75.2       66.3        8.8
   1.76  1.69  0.351   510.    0.6701    0.125     0.527     0.531       80.1       73.0        7.2
   1.69  1.62  0.382   545.    0.6934    0.066     0.523     0.524       85.2       80.4        4.8
<hr>
</pre>

<a name="cyc0005dm"><h3>Cycle    5</h3></a>
<a href="#cyc0006dm">Next cycle</a>
<a href="#tocdm">Contents</a>
<pre>

  Effective resolution:  1.617 A
  Number of reflections included:    5088
  Number of reflections excluded:       0

 Auto Wang-radius    4.6

            The masked region occupies  50.0 % of the cell.
            Maps are x-y sections with the x-axis horizontal
            and the origin top left.

 Section   0 of  96

 *****++++++**********+++++++*****************++++++*************        
 ****       **********        ****************      *************        
 ***         *********        ****************       ************        
 *           *********           ************         ***********        
 +                                 *********          **********+        
 +                                 *********          **********+        
 +                                  ********          ********  +        
 +                                  ********           *******  +        
 +                                  *******             ******  +        
 *                               *********               ********        
 ***           *****           *******                      *****        
 ***          ******          ********         *****         ****        
 ***          ******          *******         ******          ***        
 ****         *******         *******         *******         ***        
 *****        ******         *******          ******          ***        
 *****                       *******          ******          ***        
 *****                      *******             **              *        
 + *******               *******                                +        
 +  ********           *******                                  +        
 +  ********          ********                                  +        
 +  ********          *********                                 +        
 + *********          **********                                +        
 +**********          ***********            *      **          +        
 ************         *************          *********          *        
 *************       ****************        *********        ***        
 *************      ******************      **********       ****        
 *************       *****************       *********       ****        
 *************       ****************         *******         ***        
 *************      *****************                         ***        
 *************      *****************                         ***        
 **************     ****************                          ***        
 ***************   *****************                          ***        
 ***************   *****************     ***           ***     **        
 **************     ****************    ****           ****   ***        
 *************      ************************          ***********        
 *************      ***************   ******          *******   *        
 +  **********       **********       ******          ******    +        
 +    *******         *******         ******          ******    +        
 +    ******          ******          ******          ******    +        
 +    ******          ******          ******          ******    +        
 +    ******          ******          *******         *******   +        
 *    ******          *******    *************       ************        
 *** *******          ******** ***************      *************        
 ***  ******          ******  *****************     *************        
 ***    ****           ***     *****************   **************        
 ***     ***           ***     *****************   **************        
 ***                          ******************   **************        
 ***                          *****************     *************        
 ****                         ****************      *************        
 ****                         ****************      *************        
 *****+++++++*********+++++++*****************+++++++************        

 REAL/FREE-R MASKS:
   1.00 of free solvent sphere lies in solvent
   1.00 of free protein sphere lies in protein


*************************************************
* Solvent Resid :  0.256 FreeSol Resid :  0.227 *
* Protein Resid :  0.214 FreePrt Resid :  0.181 *
* Combine Resid :  0.235 FreeCmb Resid :  0.204 *
*************************************************


         % of cell   Min Rho   Max Rho   Mean Rho   Std.Dev.
 Protein:     50.0    -1.460     4.007      0.394      0.635
 Solvent:     50.0    -0.508     2.268      0.356      0.255

 Density       Number of counts:   Number of counts:
 Range:        (Protein)           (Solvent)
   -0.875              1696                   0
   -0.625              6720                  48
   -0.375             29880                1440
   -0.125             72296               23566
    0.125            105136              129858
    0.375             91724              180116
    0.625             49578               78704
    0.875             25714               20536
    1.125             17104                5568
    1.375             12528                2064
    1.625              9208                 336
    1.875              6528                  84
    2.125              4584                  48
    2.375              2760                  48


 HISTOGRAM MAPPING:
  Fcalc histograms chosen: resolution = 1.80 1.60 A
                              weights = 0.09 0.91
  Fcalc mean,std   0.435  0.819  Adjusted mean,std   0.434  0.816

    RHO       Counts    Counts       
              (Desired) (Transformed)

    -0.975     0.000759  0.000470
    -0.571     0.003672  0.003364
    -0.167     0.033548  0.032664
     0.237     0.056405  0.053880
     0.641     0.010270  0.011991
     1.045     0.005712  0.005806
     1.449     0.004444  0.004920
     1.854     0.003479  0.002496
     2.258     0.003115  0.003292
     2.662     0.002153  0.002604
     3.066     0.001335  0.001139
     3.470     0.000805  0.000868
     3.874     0.000466  0.000434

         % of cell   Min Rho   Max Rho   Mean Rho   Std.Dev.
 Protein:     50.0    -0.998     4.000      0.434      0.816
 Solvent:     50.0     0.320     0.320      0.320      0.000

 Density       Number of counts:   Number of counts:
 Range:        (Protein)           (Solvent)
   -0.875              1616                   0
   -0.625              6672                   0
   -0.375             28440                   0
   -0.125             86214                   0
    0.125            129618                   0
    0.375             78024              442416
    0.625             25968                   0
    0.875             15048                   0
    1.125             12408                   0
    1.375              9808                   0
    1.625              9024                   0
    1.875              8016                   0
    2.125              7192                   0
    2.375              6240                   0


         % of cell   Min Rho   Max Rho   Mean Rho   Std.Dev.
 Protein:     50.0    -1.388     4.014      0.394      0.638
 Solvent:     50.0    -0.604     2.354      0.356      0.262

 Density       Number of counts:   Number of counts:
 Range:        (Protein)           (Solvent)
   -0.875              1552                   0
   -0.625              7656                  96
   -0.375             30768                1680
   -0.125             71958               27256
    0.125            103674              126576
    0.375             90336              176260
    0.625             51072               79760
    0.875             25344               22152
    1.125             17608                6024
    1.375             11832                2048
    1.625              9496                 384
    1.875              6624                  84
    2.125              4632                  48
    2.375              2808                  48


 HISTOGRAM MAPPING:
  Fcalc histograms chosen: resolution = 1.80 1.60 A
                              weights = 0.09 0.91
  Fcalc mean,std   0.435  0.819  Adjusted mean,std   0.434  0.815

    RHO       Counts    Counts       
              (Desired) (Transformed)

    -0.975     0.000759  0.000579
    -0.571     0.003672  0.003473
    -0.167     0.033548  0.033804
     0.237     0.056405  0.053228
     0.641     0.010270  0.010526
     1.045     0.005712  0.005426
     1.449     0.004444  0.004286
     1.854     0.003479  0.003039
     2.258     0.003115  0.002930
     2.662     0.002153  0.002930
     3.066     0.001335  0.000977
     3.470     0.000805  0.000760
     3.874     0.000466  0.000434

 Perturbation gamma correction:
    Resolution    Gamma
        1.62      0.5142
  Overall value   0.5142

 Sigma-a refinement:  3 cycles.
 Phase combination statistics:
  Number of reflections included in phase recombination =    5088

 RMIN - RMAX    S^2   NREFLS  SIGMAA   MEAN FOM  MEAN FOM  MEAN FOM  MEAN DPHI  MEAN DPHI  MEAN DPHI
                                        (obs.)    (calc)    (comb)   |obs-cal|  |obs-com|  |cal-com|
 100.00  3.68  0.074   503.    0.5626    0.556     0.418     0.625       62.1       20.7       41.3
   3.68  2.88  0.121   504.    0.7589    0.427     0.604     0.660       54.4       38.6       15.8
   2.88  2.49  0.161   501.    0.6423    0.157     0.515     0.539       62.9       52.3       10.6
   2.49  2.25  0.197   507.    0.7493    0.145     0.635     0.648       63.2       57.4        5.8
   2.25  2.08  0.232   502.    0.7060    0.075     0.575     0.582       66.3       62.0        4.2
   2.08  1.95  0.263   504.    0.7293    0.202     0.599     0.620       61.5       53.8        7.8
   1.95  1.84  0.294   509.    0.6962    0.160     0.566     0.583       68.4       60.7        7.7
   1.84  1.76  0.323   503.    0.6579    0.098     0.530     0.538       73.6       67.9        5.7
   1.76  1.69  0.351   510.    0.7360    0.125     0.593     0.596       77.8       72.5        5.3
   1.69  1.62  0.382   545.    0.7607    0.066     0.592     0.594       80.2       77.3        2.9
<hr>
</pre>

<a name="cyc0006dm"><h3>Cycle    6</h3></a>
<a href="#cyc0007dm">Next cycle</a>
<a href="#tocdm">Contents</a>
<pre>

  Effective resolution:  1.617 A
  Number of reflections included:    5088
  Number of reflections excluded:       0

 Auto Wang-radius    4.3

            The masked region occupies  50.0 % of the cell.
            Maps are x-y sections with the x-axis horizontal
            and the origin top left.

 Section   0 of  96

 *****+++++++*********+++++++*****************++++++*************        
 ****        *********        ****************      *************        
 ***         *********         ***************       ************        
 *           *********           ************         ***********        
 +           *       *             *********          **********+        
 +                                  ********          ********* +        
 +                                  ********          ********* +        
 +                                  ********           *******  +        
 +                                  *******             ******  +        
 +                                ********               ********        
 ***           *****           *******                       ****        
 ***          ******          ********         *  **         ****        
 ***          *******         *******         *******         ***        
 ****         *******         *******         *******         ***        
 *****        ******         *******          ******          ***        
 *****                       *******          ******          ***        
 *****                      *******             **              *        
 + *******              ********                                +        
 +  ********           *******                                  +        
 +  ********          ********                                  +        
 +  ********          *********                                 +        
 +  ********          *********                                 +        
 +***********         **********             *      **          +        
 *************       *************           *********          *        
 *************      ****************         *********        ***        
 *************      *****************       **********        ***        
 *************      *****************        *********        ***        
 *************       ****************         *** ***         ***        
 *************      *****************                         ***        
 *************      *****************                         ***        
 **************     *****************                         ***        
 ***************   *****************                          ***        
 ***************   *****************     ***           ***     **        
 **************     ****************    ****          *****    **        
 *************      ************************          ***********        
 *************      ***************   ******          *******   *        
 +  **********       **********       ******          ******    +        
 +    *******         *******         ******          ******    +        
 +    ******          ******          ******          ******    +        
 +    ******          ******          ******          ******    +        
 +    ******          ******          *******         *******   +        
 *    ******          *******    *************      *************        
 *** *******          ******** ***************      *************        
 ***  ******          ******  ****************      *************        
 ***    ****          ****     *****************   **************        
 ***     ***           ***     *****************   **************        
 ***                          ******************   **************        
 ****                         *****************     *************        
 ****                         ****************      *************        
 ***          **   *          ****************       ************        
 ****++++++++*********++++++++****************+++++++************        

 REAL/FREE-R MASKS:
   1.00 of free solvent sphere lies in solvent
   1.00 of free protein sphere lies in protein


*************************************************
* Solvent Resid :  0.254 FreeSol Resid :  0.212 *
* Protein Resid :  0.184 FreePrt Resid :  0.154 *
* Combine Resid :  0.219 FreeCmb Resid :  0.183 *
*************************************************


         % of cell   Min Rho   Max Rho   Mean Rho   Std.Dev.
 Protein:     50.0    -1.553     3.941      0.395      0.671
 Solvent:     50.0    -0.531     2.002      0.355      0.252

 Density       Number of counts:   Number of counts:
 Range:        (Protein)           (Solvent)
   -0.875              2032                   0
   -0.625              9888                  96
   -0.375             32880                1576
   -0.125             73208               24016
    0.125            101746              129460
    0.375             86190              178080
    0.625             48408               80816
    0.875             24504               21544
    1.125             17256                5184
    1.375             12520                1272
    1.625              9040                 288
    1.875              7464                 144
    2.125              5496                  12
    2.375              4200                   0


 HISTOGRAM MAPPING:
  Fcalc histograms chosen: resolution = 1.80 1.60 A
                              weights = 0.09 0.91
  Fcalc mean,std   0.435  0.819  Adjusted mean,std   0.434  0.816

    RHO       Counts    Counts       
              (Desired) (Transformed)

    -0.975     0.000759  0.000796
    -0.571     0.003672  0.003582
    -0.167     0.033548  0.033076
     0.237     0.056405  0.056109
     0.641     0.010270  0.010582
     1.045     0.005712  0.005970
     1.449     0.004444  0.004667
     1.854     0.003479  0.003582
     2.258     0.003115  0.003202
     2.662     0.002153  0.001302
     3.066     0.001335  0.001520
     3.470     0.000805  0.000868
     3.874     0.000466  0.000434

         % of cell   Min Rho   Max Rho   Mean Rho   Std.Dev.
 Protein:     50.0    -0.998     4.000      0.434      0.816
 Solvent:     50.0     0.320     0.320      0.320      0.000

 Density       Number of counts:   Number of counts:
 Range:        (Protein)           (Solvent)
   -0.875              1472                   0
   -0.625              6528                   0
   -0.375             28584                   0
   -0.125             86352                   0
    0.125            129312                   0
    0.375             78264              442488
    0.625             26256                   0
    0.875             14448                   0
    1.125             12288                   0
    1.375             10344                   0
    1.625              8856                   0
    1.875              8104                   0
    2.125              7264                   0
    2.375              6072                   0


         % of cell   Min Rho   Max Rho   Mean Rho   Std.Dev.
 Protein:     50.0    -1.522     3.937      0.396      0.673
 Solvent:     50.0    -0.582     2.141      0.354      0.259

 Density       Number of counts:   Number of counts:
 Range:        (Protein)           (Solvent)
   -0.875              2064                   0
   -0.625             10152                  48
   -0.375             33408                1776
   -0.125             72696               27656
    0.125            101208              128660
    0.375             85176              171968
    0.625             49248               82744
    0.875             25176               22328
    1.125             16992                5208
    1.375             12448                1584
    1.625              9112                 360
    1.875              7296                 144
    2.125              5736                  12
    2.375              3960                   0


 HISTOGRAM MAPPING:
  Fcalc histograms chosen: resolution = 1.80 1.60 A
                              weights = 0.09 0.91
  Fcalc mean,std   0.435  0.819  Adjusted mean,std   0.434  0.815

    RHO       Counts    Counts       
              (Desired) (Transformed)

    -0.975     0.000759  0.000724
    -0.571     0.003672  0.003256
    -0.167     0.033548  0.033212
     0.237     0.056405  0.056656
     0.641     0.010270  0.010637
     1.045     0.005712  0.004993
     1.449     0.004444  0.004016
     1.854     0.003479  0.003907
     2.258     0.003115  0.002659
     2.662     0.002153  0.002008
     3.066     0.001335  0.001248
     3.470     0.000805  0.001085
     3.874     0.000466  0.000543

 Perturbation gamma correction:
    Resolution    Gamma
        1.62      0.4801
  Overall value   0.4801

 Sigma-a refinement:  3 cycles.
 Phase combination statistics:
  Number of reflections included in phase recombination =    5088

 RMIN - RMAX    S^2   NREFLS  SIGMAA   MEAN FOM  MEAN FOM  MEAN FOM  MEAN DPHI  MEAN DPHI  MEAN DPHI
                                        (obs.)    (calc)    (comb)   |obs-cal|  |obs-com|  |cal-com|
 100.00  3.68  0.074   503.    0.5831    0.556     0.434     0.631       62.8       21.9       40.8
   3.68  2.88  0.121   504.    0.7787    0.427     0.628     0.674       53.6       39.2       14.4
   2.88  2.49  0.161   501.    0.6900    0.157     0.566     0.584       62.2       55.9        6.3
   2.49  2.25  0.197   507.    0.7790    0.145     0.671     0.682       62.9       58.3        4.7
   2.25  2.08  0.232   502.    0.7517    0.075     0.627     0.632       65.5       62.5        3.0
   2.08  1.95  0.263   504.    0.7677    0.202     0.647     0.663       62.9       56.4        6.5
   1.95  1.84  0.294   509.    0.7308    0.160     0.598     0.609       69.9       62.8        7.1
   1.84  1.76  0.323   503.    0.6820    0.098     0.551     0.560       72.1       67.8        4.3
   1.76  1.69  0.351   510.    0.7704    0.125     0.635     0.638       76.1       70.9        5.2
   1.69  1.62  0.382   545.    0.7713    0.066     0.612     0.613       79.5       77.1        2.4
<hr>
</pre>

<a name="cyc0007dm"><h3>Cycle    7</h3></a>
<a href="#cyc0008dm">Next cycle</a>
<a href="#tocdm">Contents</a>
<pre>

  Effective resolution:  1.617 A
  Number of reflections included:    5088
  Number of reflections excluded:       0

 Auto Wang-radius    4.2

            The masked region occupies  50.0 % of the cell.
            Maps are x-y sections with the x-axis horizontal
            and the origin top left.

 Section   0 of  96

 ****++++++++*********++++++++****************++++++*************        
 ****        *********        ****************      *************        
 **          *********          **************       ************        
 +           *********            ***********         ***********        
 +           *       *             **********         **********+        
 +                                  *********         ********* +        
 +                                  *********         ********* +        
 +                                  ********          ********  +        
 +                                  ********           *******  +        
 +                                ********               ********        
 ***           *****           *******                       ****        
 ***          ******          ********         *  **         ****        
 ***          *******         *******         *******         ***        
 ****         *******         *******         *******         ***        
 *****        ******         *******          *******         ***        
 *****                       *******          ******          ***        
 *****                      *******             **              *        
 + *******              ********                                +        
 +  ********           *******                                  +        
 +  ********          ********                                  +        
 +  *********         *********                                 +        
 +  *********         *********                                 +        
 +***********         **********             *      **          +        
 *************       *************           *********          *        
 *************      ****************         *********        ***        
 *************      *****************       **********        ***        
 *************      *****************        *********        ***        
 *************       ***************         ***  ****        ***        
 *************       ***************                          ***        
 *************      ****************                          ***        
 **************     *****************                         ***        
 ***************   *****************      *                   ***        
 ***************   *****************     ***          ****     **        
 **************     ****************    ****          *****    **        
 *************      **************** *******          ***********        
 **************     ***************   ******          *******   *        
 +  *********         *********       ******          ******    +        
 +    *******         ******          ******          ******    +        
 +    ******          ******           *****          ******    +        
 +     *****          ******          ******          ******    +        
 +    ******          ******          *******         ******    +        
 *    ******          *******    *************      *************        
 *** *******          ******** ***************      *************        
 ***  ******          ******  ****************      *************        
 ***    ****          ****     *****************   **************        
 ***     ***          ****     *****************   **************        
 ***      *                   ******************   **************        
 ****                         *****************     *************        
 ***                          ****************      *************        
 ***          **   *          ****************       ************        
 ****++++++++*********++++++++****************+++++++************        

 REAL/FREE-R MASKS:
   1.00 of free solvent sphere lies in solvent
   1.00 of free protein sphere lies in protein


*************************************************
* Solvent Resid :  0.247 FreeSol Resid :  0.214 *
* Protein Resid :  0.169 FreePrt Resid :  0.140 *
* Combine Resid :  0.208 FreeCmb Resid :  0.177 *
*************************************************


         % of cell   Min Rho   Max Rho   Mean Rho   Std.Dev.
 Protein:     50.0    -1.539     4.025      0.396      0.689
 Solvent:     50.0    -0.594     1.945      0.354      0.245

 Density       Number of counts:   Number of counts:
 Range:        (Protein)           (Solvent)
   -0.875              2760                   0
   -0.625             10656                  96
   -0.375             33192                1192
   -0.125             74200               23632
    0.125            100946              125488
    0.375             86350              183572
    0.625             45720               81536
    0.875             23040               20680
    1.125             17448                4824
    1.375             12336                1176
    1.625             10336                  72
    1.875              7216                 108
    2.125              5736                   0
    2.375              3792                   0


 HISTOGRAM MAPPING:
  Fcalc histograms chosen: resolution = 1.80 1.60 A
                              weights = 0.09 0.91
  Fcalc mean,std   0.435  0.819  Adjusted mean,std   0.434  0.815

    RHO       Counts    Counts       
              (Desired) (Transformed)

    -0.975     0.000759  0.000832
    -0.571     0.003672  0.003364
    -0.167     0.033548  0.032064
     0.237     0.056405  0.053169
     0.641     0.010270  0.010742
     1.045     0.005712  0.004774
     1.449     0.004444  0.004774
     1.854     0.003479  0.003255
     2.258     0.003115  0.003472
     2.662     0.002153  0.002930
     3.066     0.001335  0.001302
     3.470     0.000805  0.000977
     3.874     0.000466  0.000434

         % of cell   Min Rho   Max Rho   Mean Rho   Std.Dev.
 Protein:     50.0    -0.998     4.000      0.434      0.815
 Solvent:     50.0     0.320     0.320      0.320      0.000

 Density       Number of counts:   Number of counts:
 Range:        (Protein)           (Solvent)
   -0.875              1544                   0
   -0.625              6672                   0
   -0.375             28920                   0
   -0.125             85864                   0
    0.125            128568                   0
    0.375             79128              442376
    0.625             25992                   0
    0.875             14832                   0
    1.125             11952                   0
    1.375             10248                   0
    1.625              9216                   0
    1.875              7968                   0
    2.125              7120                   0
    2.375              6016                   0


         % of cell   Min Rho   Max Rho   Mean Rho   Std.Dev.
 Protein:     50.0    -1.548     4.066      0.395      0.691
 Solvent:     50.0    -0.559     1.913      0.355      0.253

 Density       Number of counts:   Number of counts:
 Range:        (Protein)           (Solvent)
   -0.875              2616                   0
   -0.625             11616                  96
   -0.375             33432                1776
   -0.125             73432               26512
    0.125             99072              125848
    0.375             86044              176688
    0.625             47180               82852
    0.875             23880               21896
    1.125             16944                5376
    1.375             12064                1104
    1.625             10320                 120
    1.875              7768                 108
    2.125              5544                   0
    2.375              3960                   0


 HISTOGRAM MAPPING:
  Fcalc histograms chosen: resolution = 1.80 1.60 A
                              weights = 0.09 0.91
  Fcalc mean,std   0.435  0.819  Adjusted mean,std   0.434  0.816

    RHO       Counts    Counts       
              (Desired) (Transformed)

    -0.975     0.000759  0.000687
    -0.571     0.003672  0.003906
    -0.167     0.033548  0.033981
     0.237     0.056405  0.054200
     0.641     0.010270  0.011610
     1.045     0.005712  0.006999
     1.449     0.004444  0.004449
     1.854     0.003479  0.003255
     2.258     0.003115  0.002496
     2.662     0.002153  0.001953
     3.066     0.001335  0.001302
     3.470     0.000805  0.000543
     3.874     0.000466  0.000326

 Perturbation gamma correction:
    Resolution    Gamma
        1.62      0.4806
  Overall value   0.4806

 Sigma-a refinement:  3 cycles.
 Phase combination statistics:
  Number of reflections included in phase recombination =    5088

 RMIN - RMAX    S^2   NREFLS  SIGMAA   MEAN FOM  MEAN FOM  MEAN FOM  MEAN DPHI  MEAN DPHI  MEAN DPHI
                                        (obs.)    (calc)    (comb)   |obs-cal|  |obs-com|  |cal-com|
 100.00  3.68  0.074   503.    0.5815    0.556     0.433     0.630       63.1       21.7       41.4
   3.68  2.88  0.121   504.    0.7878    0.427     0.639     0.683       53.5       40.5       13.0
   2.88  2.49  0.161   501.    0.7034    0.157     0.578     0.597       62.1       55.3        6.9
   2.49  2.25  0.197   507.    0.7969    0.145     0.695     0.706       62.5       58.2        4.3
   2.25  2.08  0.232   502.    0.7688    0.075     0.649     0.655       65.1       62.6        2.5
   2.08  1.95  0.263   504.    0.7735    0.202     0.658     0.674       61.3       55.1        6.2
   1.95  1.84  0.294   509.    0.7699    0.160     0.648     0.657       69.4       64.0        5.5
   1.84  1.76  0.323   503.    0.7152    0.098     0.592     0.598       73.3       68.8        4.5
   1.76  1.69  0.351   510.    0.7900    0.125     0.664     0.667       77.0       72.7        4.3
   1.69  1.62  0.382   545.    0.7841    0.066     0.631     0.633       79.1       75.7        3.4
<hr>
</pre>

<a name="cyc0008dm"><h3>Cycle    8</h3></a>
<a href="#cyc0009dm">Next cycle</a>
<a href="#tocdm">Contents</a>
<pre>

  Effective resolution:  1.617 A
  Number of reflections included:    5088
  Number of reflections excluded:       0

 Auto Wang-radius    4.1

            The masked region occupies  50.0 % of the cell.
            Maps are x-y sections with the x-axis horizontal
            and the origin top left.

 Section   0 of  96

 ****++++++++*********++++++++****************++++++*************        
 ***         *********        ****************      *************        
 **          *********          **************       ************        
 +           *********            ***********         ***********        
 +                                 **********         **********+        
 +                                  *********         ********* +        
 +                                  *********         ********* +        
 +                                  ********          ********  +        
 +                                  ********           *******  +        
 +                                ********               ********        
 ***           *****           *******                       ****        
 ***          ******          ********         *  **         ****        
 ***          *******         *******         *******         ***        
 ****         *******         *******         *******         ***        
 *****        ******         *******          *******         ***        
 *****                       *******          ******          ***        
 *****                      *******             **              *        
 + *******              ********                                +        
 +  ********           *******                                  +        
 +  ********          ********                                  +        
 +  *********         *********                                 +        
 +  *********         *********                                 +        
 +***********         **********             *      **          +        
 *************       *************           *********          +        
 *************      ****************         *********        ***        
 *************      *****************        *********        ***        
 *************      *****************        *********        ***        
 *************       ***************         ***  ****        ***        
 *************       ***************                          ***        
 *************      ****************                          ***        
 **************     *****************                         ***        
 ***************   *****************      *                   ***        
 ***************   *****************     ***          ****     **        
 **************     ****************    ****          *****    **        
 *************      ****************  ******          ******* ***        
 **************     ***************   ******          *******   *        
 +  *********         *********       ******          ******    +        
 +    *******         ******          ******          ******    +        
 +     *****          ******           *****          ******    +        
 +     *****          ******           *****          ******    +        
 +    ******          ******          *******         ******    +        
 *    ******          ******     *************      *************        
 *** *******          ************************      *************        
 ***  *******         ******  ****************      *************        
 ***    ****          ****     *****************   **************        
 ***     ***          ****     *****************   **************        
 ***      *                   ******************   **************        
 ****                         *****************     *************        
 ***                          ****************      *************        
 ***          **   **         ****************       ************        
 ***+++++++++*********++++++++****************+++++++************        

 REAL/FREE-R MASKS:
   1.00 of free solvent sphere lies in solvent
   1.00 of free protein sphere lies in protein


*************************************************
* Solvent Resid :  0.244 FreeSol Resid :  0.205 *
* Protein Resid :  0.161 FreePrt Resid :  0.133 *
* Combine Resid :  0.203 FreeCmb Resid :  0.169 *
*************************************************


         % of cell   Min Rho   Max Rho   Mean Rho   Std.Dev.
 Protein:     50.0    -1.704     3.987      0.396      0.699
 Solvent:     50.0    -0.454     2.032      0.354      0.242

 Density       Number of counts:   Number of counts:
 Range:        (Protein)           (Solvent)
   -0.875              2952                   0
   -0.625             11760                   0
   -0.375             33288                1336
   -0.125             75194               22416
    0.125            100526              128196
    0.375             82896              185056
    0.625             45696               79224
    0.875             23808               20424
    1.125             16368                4392
    1.375             12504                1200
    1.625             10648                 168
    1.875              7440                   0
    2.125              6136                  12
    2.375              4176                   0


 HISTOGRAM MAPPING:
  Fcalc histograms chosen: resolution = 1.80 1.60 A
                              weights = 0.09 0.91
  Fcalc mean,std   0.435  0.819  Adjusted mean,std   0.434  0.816

    RHO       Counts    Counts       
              (Desired) (Transformed)

    -0.975     0.000759  0.000832
    -0.571     0.003672  0.004124
    -0.167     0.033548  0.034130
     0.237     0.056405  0.053668
     0.641     0.010270  0.010472
     1.045     0.005712  0.005318
     1.449     0.004444  0.004666
     1.854     0.003479  0.004124
     2.258     0.003115  0.002930
     2.662     0.002153  0.002008
     3.066     0.001335  0.001519
     3.470     0.000805  0.000543
     3.874     0.000466  0.000217

         % of cell   Min Rho   Max Rho   Mean Rho   Std.Dev.
 Protein:     50.0    -0.998     4.000      0.434      0.816
 Solvent:     50.0     0.320     0.320      0.320      0.000

 Density       Number of counts:   Number of counts:
 Range:        (Protein)           (Solvent)
   -0.875              1496                   0
   -0.625              6528                   0
   -0.375             29016                   0
   -0.125             86224                   0
    0.125            128832                   0
    0.375             77928              442424
    0.625             26448                   0
    0.875             15144                   0
    1.125             11544                   0
    1.375             10608                   0
    1.625              9336                   0
    1.875              7776                   0
    2.125              7144                   0
    2.375              6144                   0


         % of cell   Min Rho   Max Rho   Mean Rho   Std.Dev.
 Protein:     50.0    -1.509     3.949      0.396      0.701
 Solvent:     50.0    -0.489     2.118      0.354      0.249

 Density       Number of counts:   Number of counts:
 Range:        (Protein)           (Solvent)
   -0.875              2808                   0
   -0.625             12336                   0
   -0.375             33048                1504
   -0.125             75664               25008
    0.125             98904              128668
    0.375             84456              177696
    0.625             44760               81272
    0.875             24144               21888
    1.125             16368                5056
    1.375             12480                1152
    1.625             10224                 144
    1.875              7480                  24
    2.125              6256                  12
    2.375              4392                   0


 HISTOGRAM MAPPING:
  Fcalc histograms chosen: resolution = 1.80 1.60 A
                              weights = 0.09 0.91
  Fcalc mean,std   0.435  0.819  Adjusted mean,std   0.434  0.816

    RHO       Counts    Counts       
              (Desired) (Transformed)

    -0.975     0.000759  0.000723
    -0.571     0.003672  0.003798
    -0.167     0.033548  0.034130
     0.237     0.056405  0.057407
     0.641     0.010270  0.009496
     1.045     0.005712  0.004829
     1.449     0.004444  0.003690
     1.854     0.003479  0.003527
     2.258     0.003115  0.004015
     2.662     0.002153  0.002062
     3.066     0.001335  0.001194
     3.470     0.000805  0.000760
     3.874     0.000466  0.000271

 Perturbation gamma correction:
    Resolution    Gamma
        1.62      0.4724
  Overall value   0.4724

 Sigma-a refinement:  3 cycles.
 Phase combination statistics:
  Number of reflections included in phase recombination =    5088

 RMIN - RMAX    S^2   NREFLS  SIGMAA   MEAN FOM  MEAN FOM  MEAN FOM  MEAN DPHI  MEAN DPHI  MEAN DPHI
                                        (obs.)    (calc)    (comb)   |obs-cal|  |obs-com|  |cal-com|
 100.00  3.68  0.074   503.    0.5905    0.556     0.441     0.632       61.8       22.7       39.1
   3.68  2.88  0.121   504.    0.7984    0.427     0.656     0.693       52.8       40.8       12.0
   2.88  2.49  0.161   501.    0.7234    0.157     0.600     0.616       62.5       56.5        5.9
   2.49  2.25  0.197   507.    0.8090    0.145     0.714     0.722       62.1       59.1        3.0
   2.25  2.08  0.232   502.    0.7941    0.075     0.684     0.687       66.8       64.7        2.0
   2.08  1.95  0.263   504.    0.7881    0.202     0.679     0.691       61.8       56.7        5.1
   1.95  1.84  0.294   509.    0.7916    0.160     0.677     0.683       70.7       64.4        6.3
   1.84  1.76  0.323   503.    0.7353    0.098     0.613     0.619       71.8       68.4        3.3
   1.76  1.69  0.351   510.    0.8112    0.125     0.698     0.701       75.1       70.6        4.5
   1.69  1.62  0.382   545.    0.7943    0.066     0.650     0.653       77.5       75.6        1.9
<hr>
</pre>

<a name="cyc0009dm"><h3>Cycle    9</h3></a>
<a href="#cyc0010dm">Next cycle</a>
<a href="#tocdm">Contents</a>
<pre>

  Effective resolution:  1.617 A
  Number of reflections included:    5088
  Number of reflections excluded:       0

 Auto Wang-radius    4.1

            The masked region occupies  50.0 % of the cell.
            Maps are x-y sections with the x-axis horizontal
            and the origin top left.

 Section   0 of  96

 ****++++++++*********++++++++****************++++++*************        
 ***         *********        ****************      *************        
 **          *********          **************       ************        
 +           *********            ***********         **********+        
 +                                 **********         **********+        
 +                                  *********         ********* +        
 +                                  *********         ********* +        
 +                                  ********          ********  +        
 +                                  ********           *******  +        
 +                                *******                 *******        
 ***           *****           *******                       ****        
 ***          ******          ********         *  **         ****        
 ***          *******         *******         *******         ***        
 ****         *******         *******         *******         ***        
 *****        ******         *******          *******         ***        
 *****                       *******          ******          ***        
 *****                       ******             ***             *        
 + *******              ********                                +        
 +  ********           *******                                  +        
 +  *********         ********                                  +        
 +  *********         *********                                 +        
 +  *********         *********                                 +        
 + **********         **********             *      **          +        
 *************       *************           *********          +        
 *************      ****************         *********         **        
 *************      *****************        *********        ***        
 *************      ****************         *********        ***        
 *************       ***************         ***  ****        ***        
 *************       ***************                          ***        
 *************      ****************                          ***        
 **************     ****************                          ***        
 ***************   *****************      *                   ***        
 ***************   *****************     ***          ****     **        
 **************     ****************    *****         *****    **        
 *************      ****************  ******          ******* ***        
 **************     ***************   ******          *******   *        
 +  *********         *********       ******          ******    +        
 +    ******          ******          ******          ******    +        
 +     *****          ******           *****          ******    +        
 +     *****          ******           *****          ******    +        
 +    ******          ******          ******          ******    +        
 *    ******          *******    *************      *************        
 *** *******          *************************     *************        
 ***  *******         ******  ****************      *************        
 ***    ****          ****     *****************   **************        
 ***     ***          ****     *****************   **************        
 ***      *                   ******************   **************        
 ***                          *****************     *************        
 ***                          ****************      *************        
 ***          **   **         ****************       ************        
 ***+++++++++*********++++++++****************+++++++************        

 REAL/FREE-R MASKS:
   1.00 of free solvent sphere lies in solvent
   1.00 of free protein sphere lies in protein


*************************************************
* Solvent Resid :  0.242 FreeSol Resid :  0.208 *
* Protein Resid :  0.153 FreePrt Resid :  0.135 *
* Combine Resid :  0.197 FreeCmb Resid :  0.172 *
*************************************************


<a name="dataoutdm"><h3>Data output</h3></a>
<applet width=" 400" height=" 300" code="JLogGraph.class" 
codebase="/net/sharptail/scratch1/phzwart/ccp4_6.0/test_it/ccp4-6.0/bin"><param name="table" value="
 $TABLE: Phase and weight statistics :
 $GRAPHS: Mean change in phase :N:1,2:
        : Mean figures of merit:N:1,3,4:
 $$
 1/resol^2   dphi/degrees  FOMobs      FOMdm $$
 $$
        0.074      22.679       0.556       0.632
        0.121      40.778       0.427       0.693
        0.161      56.527       0.157       0.616
        0.197      59.113       0.145       0.722
        0.232      64.749       0.075       0.687
        0.263      56.654       0.202       0.691
        0.294      64.382       0.160       0.683
        0.323      68.448       0.098       0.619
        0.351      70.633       0.125       0.701
        0.382      75.603       0.066       0.653
 $$
"><b>For inline graphs use a Java browser</b></applet>
<applet width=" 400" height=" 300" code="JLogGraph.class" 
codebase="/net/sharptail/scratch1/phzwart/ccp4_6.0/test_it/ccp4-6.0/bin"><param name="table" value="
 $TABLE: Density Modification-Free-R factors :
 $GRAPHS: Variation of Free-Residuals :N:1,2,3:
 $$
 Cycle_number  Free_R_factor Real_Space_Free_R $$
 $$
          1      0.000     0.367
          2      0.000     0.299
          3      0.000     0.263
          4      0.000     0.217
          5      0.000     0.204
          6      0.000     0.183
          7      0.000     0.177
          8      0.000     0.169
 $$
"><b>For inline graphs use a Java browser</b></applet>



 WRITTEN OUTPUT MTZ FILE 
 Logical Name: HKLOUT   Filename: dm.mtz 

 * Title:

 None

 * Base dataset:

        0 HKL_base
          HKL_base
          HKL_base

 * Number of Datasets = 1

 * Dataset ID, project/crystal/dataset names, cell dimensions, wavelength:

        1 project
          crystal
          dataset
             76.8550   76.8550   76.8550   90.0000   90.0000   90.0000
             1.00000

 * Number of Columns = 10

 * Number of Reflections = 5088

 * Missing value set to NaN in input mtz file

 * Column Labels :

 H K L FOBS SIGFOBS FMODEL PHMODEL FOM D CVFLAGS

 * Column Types :

 H H H F Q F P W W I

 * Associated datasets :

 0 0 0 1 1 1 1 1 1 1

 * Cell Dimensions : (obsolete - refer to dataset cell dimensions above)

   76.8550   76.8550   76.8550   90.0000   90.0000   90.0000 

 *  Resolution Range :

    0.00102    0.38228     (     31.376 -      1.617 A )

 * Sort Order :

      0     0     0     0     0

 * Space group = 'I4132' (number     214)


 Number of reflections on file:    5088
 Number of reflections modified:   5088
</pre>
<B><FONT COLOR="#FF0000"><!--SUMMARY_BEGIN-->
 dm:   DM - normal termination 
Times: User:     103.3s System:    0.1s Elapsed:     1:50  
</pre>
</html>
<!--SUMMARY_END--></FONT></B>