Type: INT 97-28 **NSF/Tokyo Report: US-Japan Seminar: Pesticides and the
Future - Minimizing Chronic Exposure of Humans and the Environment**

Org: INT

Date: 6/30/97

Replaces: None

The National Science Foundation\'s offices in Tokyo and in Paris
periodically report on developments abroad that are related to the
Foundation\'s mission. These documents present facts for the use of NSF
program managers and policy makers; they are not statements of NSF
policy.

Special Scientific Report #97-20 (June 23, 1997)

**US-Japan Seminar: Pesticides and the Future - Minimizing Chronic
Exposure of Humans and the Environment**

The following report was submitted by ***Dr. Ronald J. Kuhr***, Dept. of
Entomology, Box 7613 North Carolina State University, Raleigh, NC
27695-7613. ***Dr. Kuhr***, in conjunction with Professor Naoki
Motoyama, Faculty of Horticulture, **Chiba University**, Chiba, Japan,
helped organize this U.S.-Japan seminar. The workshop was held May
26-30, 1997 in Kisarazu, Japan. The workshop was jointly sponsored by
NSF and the Japan Society for the Promotion of Science (JSPS). This
project is one of the joint projects supported under the **U.S.-Japan
Cooperative Science Program**. ***Dr. Kuhr*** can be reached via email
at: ***ron_kuhr@ncsu.edu***

Seminar Report

A very successful Joint United States-Japan Seminar was held on May

26-30, 1997 at the Okura Akademia Park Hotel and Kazusa Akademia Hall in
Kisarazu. The seminar was jointly sponsored by NSF and the Japan Society
for the Promotion of Science and was titled \"**Pesticides and the
Future: Minimizing Exposure of Humans and the Environment\"**.

The seminar brought together over 30 speakers from both countries with
expertise in a variety of disciplines related to the topic. Although
efforts continue toward reduction or elimination of pesticide chemicals
in the management of pests in agriculture, public health and the urban
arena, chemicals will continue to be one of the main weapons in control
of insects, weeds, nematodes, plant diseases, etc. for some time to
come. While considerable information is known about the acute toxicity
of these compounds, information on the chronic effects from exposure to
minute amounts of pesticide residues in food, water, air and soil is
often very limited. The seminar approached the topic from several
different vantage points including pesticide epidemiology, new modes of
action to minimize nontarget exposure, bioremediation of contaminated
areas, molecular biology of the modes of action and detoxication of
pesticides, and the dynamics of pesticide movement in the environment.

As world leaders in the manufacture and use of pesticides, the two
countries must cooperate in the search for safer pesticides with minimum
chronic effects on humans and the environment. Discussions during the
seminar helped to remove the barriers of distance and language and
should lead to new cooperative research efforts across country lines and
discipline lines.

Below is an agenda for the seminar:

**1997 UNITED STATES - JAPAN JOINT SEMINAR**

**Pesticides and the Future: Minimizing Chronic Exposure of Humans and**

**the Environment**

**Monday Evening, May 26 - Welcoming Reception**

4:00-6:00 Welcoming remarks from Drs. Naoki Motoyama and Ronald J.

Kuhr, Seminar Organizers

**Tuesday Morning, May 27 - Epidemiology of Pesticides**

8:30-9:10 Herbicides and Gallbladder Cancer in Japan - Dr. Masaharu

Yamamoto, Niigata University, Japan

9:10-9:50 Integrated Method for Evaluating the Cancer Risk and

Noncancer Risk due to Pesticides - Dr. Junko Nakanishi, Yokohama

National University, Japan

9:50-10:05 Break

10:05-10:45 Pesticides and Cancer - Dr. David F. Goldsmith,

> Public Health Institute, USA

10:45-11:25 Pitfall of Epidemiology - An Evaluation of the Recent

Study on a Pesticide and Cancer Relationship - Dr. Seiya Yamaguchi,

University of Tsukuba/Environmental and Occupational Health

Institute, Japan

11:25-11:40 Lack of Preneoplastic Changes and Induction of CYP2B11 in
the

> Liver of Dogs Treated with CNP - Dr. Yasuo Ohno, Nat.Institute of
> Health Sciences, Japan

11:40-11:55 Role of Epidemiology in Carcinogenic Risk Assessment - Dr.
Naohito

> Yamaguchi, National Cancer Center Research Institute, Japan

12:15-1:45 Lunch

**Tuesday Afternoon, May 27 - Chronic Effects of Pesticides on Health**

2:00-2:45 Plenary Lecture - Nicotine: Old and New Topic - Dr. Izuru

> Yamamoto, Tokyo University of Agriculture, Japan

2:45-3:25 Chronic Effects of Exposure to TCDD - Dr. Fumio Matsumura,

> University of California, Davis, USA

3:25-4:05 Effect of Ingestion of 20 or 40 Pesticides in Combination at
ADI Levels

> on Carcinogenesis in Rats - Dr. Nobuyuki Ito, Nagoya City University,
>
> Japan

4:05-4:20 Break

4:20-5:00 Herbicides and Olfactory/Neurotoxicity Responses - Dr. Mary

> Beth Genter, University of Cincinnati, USA

5:00-5:40 Cancer as a Disease of Environment and a Disease of Genes -
Dr.

> Toshio Kuroki, Showa University, Japan

**Wednesday Morning, May 28 - Safer Insecticides**

8:30-9:10 Biological Properties of Chloronicotinyl Insecticide

> Imidaclorprid - High Selectivity and Safer Use in the Practice -
>
> Dr. Koji Iwaya, Nihon Bayer Agrochem K. K., Japan

9:10-9:50 Spinosad and Related Compounds - Dr. Gary D. Crouse,

> DowElanco, USA

9:50-10:05 Break

10:05-10:45 Fipronil and Related Compounds - Dr. Daniel B. Gant,

> Rhone-Poulenc, USA

10:45-11:25 Genetically Engineered Bt Products - Dr. Takashi Yamamoto,

> Novartis, USA

11:45-1:15 Lunch

**Wednesday Afternoon, May 28 - Discussion and Tour of Local Area**

**Thursday Morning, May 29 - Bioremediation of Pesticide Residues**

8:30-9:10 Use of Insect Genes in Bioremediation - Dr. R. Michael Roe,

> North Carolina State University, USA

9:10-9:50 Engineering Microorganisms Capable of Efficient Degradation of

> Chlorinated Environmental Pollutants - Dr. Kensuke Furukawa,
>
> Kyushu University, Japan

9:50-10:05 Break

10:05-10:45 Use of Fungi in Bioremediation - Dr. James D. Stahl, Intech

> One-Eighty Corporation, USA

10:45-11:25 Organic Sorption/Biodegradation of Pesticides - Dr. Donald

> E. Mullins, VPI&SU, USA

11:45-1:15 Lunch

**Thursday Afternoon, May 29 - Biochemical and Molecular Biology of**

> **Pesticides**

1:30-2:15 Plenary Lecture - Potential of Recombinant

> Baculoviruses as Insect Control Agents - Dr. Bruce D. Hammock,
>
> University of California, Davis, USA

2:15-2:55 Molecular Action Mechanism of Nonfungicidal Anti-blast
Chemicals -

> Dr. Isamu Yamaguchi, The Institute of Physical and Chemical Research
>
> (RIKEN), Japan

2:55-3:35 Cytochrome P450 and Human Toxicity - Dr. Ernest Hodgson, North

> Carolina State University, USA

3:35-3:50 Break

3:50-4:30 Molecular Mechanisms of Herbicide Resistance - Dr. Hideo

Ohkawa, Kobe University, Japan

4:30-5:10 Oxidative Phosphorylation and Pesticides - Dr. Robert M.

> Hollingworth, Michigan State University, USA

**Thursday Evening, May 29 - Banquet**

**Friday Morning, May 30 - Pesticide Ecology/Dynamics**

8:30-9:10 Prediction of Pesticide Behavior in Paddy Field Using

Simulation Model - Dr. Kazuhiro Takagi, National Institute of

> Agro-Environmental Sciences, Japan

9:10-9:50 Long Distance Air Transport of Pesticides - Dr. James N.

> Seiber, University of Nevada Reno, USA

9:50-10:05 Break

10:05-10:45 Assessing the Side-effects of Pesticides on Soil
Ecosystems - Dr. Hiroki

> Yamamoto, Shimane University, Japan

10:45-11:25 Sustainable Agriculture and Pesticides - Dr. Raymond Forney,

> Du Pont, USA

11:25-12:05 Assessment of Overall Pesticide Effects on River Ecosystems
-

> Dr. Shigehisa Hatakeyama, National Institute for Environmental
>
> Studies, Japan

**Friday Afternoon, May 30 - Concluding Luncheon**

12:15-1:30 Lunch/Concluding Remarks from Drs. Ronald J. Kuhr and Naoki

> Motoyama, Seminar Organizers