# Curriculum Vitae

# 

# Dennis D. Hickstein, M.D.

[Office Address:]{.underline} Senior Investigator

Head, Molecular Oncology and Gene Transfer

Experimental Transplantation and Immunology Branch

Center for Cancer Research

National Cancer Institute

Bldg. 10 CRC, 3-3142 (3 East Labs)

10 Center Drive, MSC 1907

Bethesda, MD 20892

Email: hicksted@mail.nih.gov

[Office Telephone:]{.underline} 301-594-1718

[Office FAX]{.underline}: 301-402-5054

[Education:]{.underline} B.A., University of Nebraska, 1974 (History)

M.D., University of Nebraska Medical Center,1978 (Medicine)

[Sabbatical:]{.underline} Visiting Scientist 9/1/94 to 8/30/95

Laboratory of Dr. Tak W. Mak

Ontario Cancer Institute, Princess Margaret Hospital

610 University Avenue, Room 8-712

Toronto, Ontario, Canada M5G 2M9

[Postgraduate Training and Fellowship Appointments]{.underline}

1978-79 Internship, Internal Medicine, University of Michigan Medical

Center, Ann Arbor, Michigan

1979-80 Assistant Resident, Internal Medicine, University of Michigan

Medical Center, Ann Arbor, Michigan

> 1980-81 Senior Assistant Resident, Internal Medicine, University of
> Michigan Medical Center, Ann Arbor, Michigan

84. Fellow in Hematology, Department of Medicine, University of
    Washington, Seattle Washington

[Faculty Appointments]{.underline}

> 1981-82 Clinical Instructor, Department of Internal Medicine,
> University of Michigan Medical Center, Ann Arbor, Michigan
>
> 1984-86 Acting Instructor, Division of Hematology, Department of
> Medicine, University of Washington, Seattle, Washington

1987 Assistant Professor of Medicine, Division of Hematology, Department
of Medicine, University of Washington School of Medicine, Seattle,
Washington

1991 Associate Professor of Medicine, Division of Hematology, Department
of Medicine, University of Washington School of Medicine, Seattle,
Washington

1996 Associate Professor of Medicine, Division of Oncology, Department
of Medicine, University of Washington School of Medicine, Seattle,
Washington

2000. Investigator, Experimental Transplantation and Immunology,

> Center for Cancer Research, National Cancer Institute, Bethesda, MD

2003 Mentor, Comparative Molecular Pathology Graduate Training Program,
Center for Cancer Research, National Cancer Institute, Bethesda, MD

> 2004 Member, Comparative Molecular Oncology Program, Center for Cancer
> Research, National Cancer Institute, Bethesda, MD

[Hospital Appointments]{.underline}

1984 Staff Physician, Department of Medicine, VA Puget Sound Health Care
System, Seattle, Washington

> 1997 Affiliate Investigator, Division of Clinical Research, Fred
> Hutchinson Cancer Research Center, Seattle, Washington
>
> 2000 Clinical Investigator, Warren Grant Magnuson Clinical Research
> Center, National Institutes of Health, Bethesda, Maryland
>
> 2000 Clinical Investigator, Mark O. Hatfield Clinical Research Center,
> National Institutes of Health, Bethesda, Maryland

[Professional Honors or Recognition]{.underline}

[Specialty Certifications]{.underline}

> National Board of Medical Examiners, Part I, 1976
>
> National Board of Medical Examiners, Part II[,]{.underline} 1978
>
> National Board of Medical Examiners, Part III, 1979
>
> Basic and Advanced Cardiac Life Support, 1981
>
> American Board of Internal Medicine, 1981
>
> American Board of Hematology, 1985

[Licensure]{.underline}

> State of Michigan, 1979-1984
>
> State of Washington, 1982-present
>
> Basic Cardiac Life Support, 2001, Renewal 2005
>
> Advanced Cardiac Life Support, 2001

[Awards, Honors, and Membership in Societies]{.underline}

Phi Alpha Theta Honorary History Society, 1990

American College of Physicians (Member)

American Medical Association

American Federation of Clinical Research

American Society of Hematology

American Society of Biochemistry and Molecular Biology

American Society of Clinical Investigation, 1994

> American Society of Gene Therapy 1998-2007
>
> [Grant Funding]{.underline}
>
> Veterans Affairs Career Development Program, Associate Investigator
> Award, \"Myeloperoxidase deficiency- a model for enzyme replacement.\"
> VA Puget Sound Health Care System, Seattle, WA, 1985-1987, Principal
> Investigator.
>
> Veterans Affairs Career Development Program, Research Associate Award,
> \"Molecular Cloning of leukocyte adherence glycoproteins.\" VA Puget
> Sound Health Care System, Seattle, WA, 1987-1991, Principal
> Investigator.
>
> Veterans Affairs Career Development Program, Clinical Investigator
> Award, \"Molecular biology of leukocyte integrins.\" VA Puget Sound
> Health Care System, Seattle, WA, 1991-1996, Principal Investigator.
>
> Veterans Affairs Merit Review Award, \"Molecular cloning of neutrophil
> adherence complex.\" VA Puget Sound Health Care System, Seattle, WA,
> 1987-1990, Principal Investigator.
>
> Veterans Affairs Merit Review Award, \"Molecular biology of
> neutrophil-endothelial cell adherence.\" VA Puget Sound Health Care
> System, Seattle, WA, 1990-1993, Principal Investigator.
>
> Veterans Affairs Merit Review Award, \"Structure and function of
> neutrophil adherence receptor.\" VA Puget Sound Health Care System,
> Seattle, WA, 1994-1999, Principal Investigator.
>
> March of Dimes Birth Defects Foundation, \"Molecular studies in
> leukocyte adherence deficiency.\" University of Washington School of
> Medicine, Seattle, WA, 1991-1993, 1993-1995, 1995-1997, Principal
> Investigator.
>
> National Institutes of Health, First Investigator Research Support in
> Transition Award (FIRST) Award, \"Molecular Regulation of Neutrophil
> Receptor.\" National Institutes of Health, University of Washington
> School of Medicine, Seattle, WA, 1991-1996, Principal Investigator.
>
> National Institutes of Health, CORE Center in Gene Therapy, Pilot
> Project \"Retroviral-mediated gene transfer in leukocyte adherence
> deficiency,\" University of Washington School of Medicine, Seattle,
> WA, 1994-1996, Principal Investigator.
>
> National Institutes of Health, CORE Center in Gene Therapy,
> Hematopoietic Cell Transduction, University of Washington School of
> Medicine, Seattle, WA, 1996-1999, 1999-2001, Co- Principal
> Investigator.
>
> National Institutes of Health, \"Gene transfer in leukocyte adherence
> deficiency," Shannon Award, NIDDK, University of Washington School of
> Medicine, Seattle, WA, 1994-1995, Principal Investigator.
>
> National Institutes of Health RO1, \"Gene transfer in leukocyte
> adherence deficiency, \" University of Washington School of Medicine,
> Seattle, WA, 1995-1998, Principal Investigator.
>
> National Institutes of Health, \"Leukocyte adherence deficiency- model
> for stem cell gene transduction.\" Specialized Center of Excellence in
> Stem Cell Biology, NHLBI, Subcontract through Fred Hutchinson Cancer
> Research Center, 9/1/95 to 8/30/2000 (Dennis D. Hickstein, M.D.,
> Principal Investigator ,Project 7, University of Washington School of
> Medicine, Seattle, WA)
>
> Veterans Affairs Merit Review Award, \"TLS Fusion Proteins in
> Leukemia," 4/1/2000 to 3/30/2005 (Dennis D. Hickstein, M.D., P.I.),
> University of Washington School of Medicine, Seattle, WA, Principal
> Investigator.
>
> National Institutes of Health, NHLBI, \"Leukocyte adherence
> deficiency- a model for stem cell gene transduction.\" Specialized
> Center of Excellence in Stem Cell Biology, NHLBI, 9/1/2000 to
> 8/30/2005 (Dennis D. Hickstein, M.D., Principal Investigator on
> Project 7), University of Washington School of Medicine, Seattle, WA
>
> National Institutes of Health RO1, \"Ewing's sarcoma fusion protein.
> \" University of Washington School of Medicine, Seattle, WA,
> 2001-2005, Principal Investigator.

[Committees]{.underline}

> Member, Scientific Review, VA Puget Sound Health Care System, Seattle,
> WA, 1987-88
>
> Chairman, Scientific Review, VA Puget Sound Health Care System,
> Seattle, WA, 1989
>
> Member, Research and Development Committee, VA Puget Sound Health Care
> System, Seattle, WA, 1988-90
>
> Member, Search Committee, Hematopathology, VA Puget Sound Health Care
> System, Seattle, WA and the Department of Pathology University of
> Washington School of Medicine, Seattle, WA, 1993-1994
>
> Member, Search Committee for Associate Director for GRECC, VA Puget
> Sound Health Care System, Seattle, WA and Associate Professor in
> Pharmacology, University of Washington School of Medicine, Seattle,
> WA, 1994-1995
>
> Member, Research and Development Committee, VA Puget Sound Health Care
> System, Seattle, WA, 1997-1998
>
> Chairman, Scientific Review Committee, VA Puget Sound Health Care
> System, Seattle, WA, 1997-98
>
> Member, Search Committee for Chief of Pathology, VA Puget Sound Health
> Care System, Seattle, WA and Professor in Pathology, University of
> Washington School of Medicine, Seattle, WA. 1998-1999
>
> Member, Search Committee for Associate Chief of Staff for Research, VA
> Puget Sound Health Care System, Seattle, WA, and University of
> Washington School of Medicine, Seattle, WA, 1999-2000
>
> Member, Fellowship Committee, Medical Oncology, National Cancer
> Institute, Bethesda, MD, 2001-2007
>
> Outside Examiner, Doctor of Philosophy Defense, Mariaestela Ortiz, The
> George Washington University, September 16, 2005

American Society of Gene Therapy, Abstract Review Committee for
Hematology, 2007

Division of Veterinary Resources (DVR) Advisory Committee, NIH, 2007

Interagency Coordinating Committee for Hematology Research, NIDDK,
"Overcoming Barriers to the Clinical Development of Gene Targeted
Therapies for Hematologic Diseases," NIH, January 14, 2008

[AD HOC Reviewer]{.underline}

> [Journal of Clinical Investigation]{.underline}
>
> [Human Gene Therapy]{.underline}
>
> [Journal of Immunology]{.underline}
>
> [BLOOD]{.underline}
>
> [Cancer]{.underline}
>
> [Journal of Leukocyte Biology]{.underline}
>
> [Proceedings of the National Academy of Sciences]{.underline}
>
> [Oncogene]{.underline}

[NIH Study Section]{.underline}

> National Heart, Lung and Blood, Center for Excellence in Molecular
> Hematology, 1995
>
> National Cancer Institute, Special Emphasis Panel on Leukemia, 1996
>
> National Cancer Institute, Specialized Center of Excellence on
> Leukemia, 2000
>
> National Institute of Diabetes, Digestive, and Kidney Diseases, RO1
> Reviewer, 2002
>
> National Institutes of Health, Hematopoiesis RO1 Study Section,
> October 5-6, 2006
>
> National Institutes of Health, Hematopoiesis RO1 Study Section, June
> 7-8, 2007

[Non-NIH Peer Review Activity]{.underline}

> University of California, Office of Health Affairs, 1992
>
> University of California, Office of Health Affairs, 1993
>
> University of California, Office of Health Affairs, 1994
>
> Ad Hoc Reviewer, Veterans Affairs, Career Development, and Merit
> Review.

[Meetings and Scientific Review Boards]{.underline}

> Member, Myeloid Biology Scientific Subcommittee, American Society of
> Hematology 1994
>
> Member, Myeloid Biology Scientific Subcommittee, American Society of
> Hematology 1995
>
> Chairman, Myeloid Biology Scientific Committee, American Society of
> Hematology, 1996
>
> Scientific Review Board, National Gene Vector Laboratories 2001-2002,
> 2002-2004, 2004-2006, 2006-2008
>
> American Society of Gene Therapy, Member, Cancer Gene Therapy
> Committee, 2003-07
>
> Co-Host, International meeting on "Gene Therapy for Inherited Immune
> Deficiencies: Advances and Safety Issues," held in Bethesda, MD,
> September 18 and 19, 2006
>
> Chairman, NIH Research Festival Symposium on "Hematopoietic Gene
> Therapy for Genetic Immunodeficiency Diseases, Bethesda, MD, October
> 18, 2006
>
> Chairman, Myeloid Biology Scientific Committee, American Society of
> Hematology, 2007 and 2008
>
> Member, Scientific Committee Chairs Meeting, American Society of
> Hematology Program Meeting, Washington, DC, January 23, 2007
>
> Gene Therapy Fingerprinting Session, Rockledge, Bethesda, MD, January
> 31, 2007

[Patents and INDs]{.underline}

> Investigational New Drug Application (IND) \# 7949 Mobilized
> (Granulocyte Colony-Stimulating Factor) Autologous peripheral Blood
> Stem Cells (CD34+, Baxter or CellPro) Cultured Ex Vivo with Cytokines;
> Transduced with Retroviral Vector (PG13/LgCD18, NGVL) Expressing CD18
> Gene

[Attending Responsibilities (2000- 2007)]{.underline}

Attending Physician, Hematopoietic Stem Cell Transplantation, National
Cancer Institute,

National Institutes of Health, Clinical Research Center, 2001-2007

[Post-doctoral Fellows Trained]{.underline}

Anthony Back, M.D. 1989-1995 Clinical Investigator Development Award

Associate Professor of Medicine, Division of Oncology, University of
Washington School of Medicine, Associate Member, Fred Hutchinson Cancer
Research Center, Seattle, WA

Richard Cornwell, M.D. 1990-1994 Clinical Investigator Development Award

Associate Professor of Medicine, Division of Pulmonary and Respiratory
Medicine, University of Wisconsin School of Medicine, Madison, WI

Andrew Aprikian, Ph.D. 1993-1998 Research Assistant Professor of
Medicine, Division of Hematology, University of Washington School of
Medicine, Seattle, WA

Bogdan Kwiatkowski, Ph.D. 1992-99 Senior Research Scientist, Department
of Biological Structure, University of Washington School of Medicine,
Seattle, WA

Mary Gearn, M.D. 1993-1996 Medical Oncology, St. Lukes Mt. States, Tumor
Institute, Boise, ID

Liu Yang, Ph.D. 1995-2000 Associate Professor, Department of Pathology,
University of Arkansas for Medical Sciences in Little Rock, Little Rock,
AK

Thomas Bauer, Ph.D. 1992-1998 Staff Scientist, Experimental
Transplantation and Immunology Branch, National Cancer Institute,
Bethesda, MD

Robert Sokolic, M.D. 2002-2006 Staff Clinician, National Human Genome
Research Institute, National Institutes of Health, Bethesda, MD

Katy Creevy, D.V.M. 2001-2004 Internal Medicine Resident, College of
Veterinary Medicine, University of Georgia, Athens, GA

Mehreen Hai, Ph.D. 2003-current Post-doctoral fellow, Experimental
Transplantation and Immunology Branch, National Cancer Institute,
Bethesda, MD

Hatem Sabaawy, M.D. 2003-2007 Assistant Professor of Medicine, College
of Medicine and Dentistry, Cancer Center of New Jersey, K22 Award from
the NCI, 2007-2010

Yu-chen Gu, Ph.D. 2002-2007 Staff Scientist, Children's Hospital of
Philadelphia, Philadelphia, PA

[Invited Lectures (1999- 2006)]{.underline}

> "Leukocyte Adhesion Deficiency Treatment with Gene Therapy." Presented
> at the Foundation Juan March Symposium, Madrid , Spain, July 9, 1999.
>
> "Gene Therapy of the Genetic Disease Leukocyte Adhesion Deficiency."
> Presented at the University of Utah School of Medicine, Salt Lake
> City, Utah, April 10, 2000.
>
> "Gene Therapy for Leukocyte Adhesion Deficiency." Presented at
> Experimental Transplantation and Immunology seminar, National Cancer
> Institute, Bethesda, MD, April 19, 2000.
>
> "Genetic Therapy for Leukocyte Disorders." Presented at Stanford
> University School of Medicine, Palo Alto, CA, February 14, 2002.
>
> "Gene Therapy for Leukocyte Adhesion Deficiency." Presented at Cancer
> Grand Rounds at the James Brown Cancer Center, Louisville, KY, April
> 2002
>
> "Canine Leukocyte Adhesion Deficiency Model." Presented at Children's
> Hospital of Philadelphia, Philadelphia, PA, May 2002.
>
> "Hematopoietic Stem Cell Therapy for the Genetic Disease Leukocyte
> Adhesion Deficiency." Presented at the Blood Center of SE Wisconsin,
> Milwaukee, WI, September 6, 2002.
>
> "Stem Cell Transplant for Leukocyte Adhesion Deficiency." Presented at
> Bone Marrow Transplant seminar, at Vanderbilt University Medical
> Center, Nashville, TN, February 21, 2003.
>
> "Hematopoietic Stem Cell Therapy for Genetic Disease." Presented at
> Hematology Grand Rounds at Vanderbilt University Medical Center,
> Nashville, TN, April 14, 2004.
>
> "Canine Leukocyte Adhesion Deficiency- Beyond the Irish Setter."
> Presented at the National Capitol Area Branch of the American
> Association for Laboratory Animal Science,
>
> Bethesda, MD, March 10, 2005.
>
> "TEL-AML1 Induced Acute Lymphoblastic Leukemia in Zebrafish."
> Presented at the Myeloid Biology Workshop, Annapolis, MD, May 7, 2005.
>
> "Canine Leukocyte Adhesion Deficiency." Presented at Cornell
> University School of Veterinary Medicine, Ithaca, NY, May 12, 2006.
>
> American Society of Gene Therapy Press Conference, "Foamy Viruses for
> delivering new genes into cells to correct LAD is successful,"
> Baltimore, MD, June 1, 2006
>
> "Canine Leukocyte Adhesion Deficiency as a Model for New Approaches to
> the Treatment of Leukocyte Adhesion Deficiency in Children," presented
> at the International meeting on Gene Therapy for Inherited Immune
> Deficiencies: Advances and Safety Issues, held in Bethesda, MD,
> September 18 and 19, 2006
>
> "Gene Therapy Approaches for Leukocyte Adhesion Deficiency Using the
> Canine Leukocyte Adhesion Deficiency Model," presented at the NIH
> Research Festival Symposium on "Hematopoietic Gene Therapy for Genetic
> Immunodeficiency Diseases, Bethesda, MD, October 18, 2006
>
> "New Therapeutic Approches Canine Leukocyte Adhesion Deficiency- Parts
> 1 and 2" Presented at Cornell University School of Veterinary
> Medicine, Ithaca, NY, April 30, 2007.
>
> "Zebrafish Model of TEL-AML1 induced leukemia," presented at the
> Lorentz Center- Model Systems for Infectious Disease and Cancer in
> Zebrafish, Leiden, The Netherlands, July 16, 2007.
>
> "Canine Leukocyte Adhesion Deficiency Model for New Therapeutic
> Approaches of LAD," presented at the 8^th^ International Veterinary
> Immunology Symposium, Ouro Preto, Brazil, August 17, 2007.
>
> "Foamy Viral Vector Gene Therapy for Canine Leukocyte Adhesion
> Deficiency, " presented at the 4^th^ Hematopoietic Stem Cell Gene
> Therapy Meeting, Thessaloniki, Greece, September 14, 2007.
>
> "Successful Foamy Viral Vector Mediated Gene Therapy for Canine
> Leukocyte Adhesion Deficiency, " presented at Myeloid Biology
> Subcommittee at the American Society of Hematology annual meeting
> Atlanta, GA December 8, 2007
>
> "Overcoming Barriers to the Clinical Development of Gene Targeted
> Therapies for Hematologic Diseases," presented at the Interagency
> Coordinating Committee for Hematology Research, NIDDK, NIH, January
> 14, 2008

**BIBLIOGRAPHY**

[Journal Articles]{.underline}

1\. Hickstein, D.D., and R.L. Linton. 1976. Medical education and
community orientation. Nebr. Med. J. 61:92-93.

2\. Hickstein, D.D., M.L. Wharton, and T.R. Gravelyn. 1981. Giant cell
arthritis and polymyalgia rheumatica in a conjugal pair. Arthritis and
Rheumatism. 24: 12-13

3\. Hickstein, D.D., and J.T. Dillon. 1982. [Klebsiella]{.underline}
pneumoniae Meningitis. Intravenous trimethoprim-sulfamethoxazole
treatment. JAMA. 248: 1212-1213

4\. Hickstein, D.D., W.F. Chandler, and J.C. Marshall. 1986. The
spectrum of pituitary adenoma hemorrhage. Western J. Med. 144: 433-436.

5\. Wallis W. J., D.D. Hickstein, B.R. Schwartz, C.H. June, H.D. Ochs,
P.G. Beatty, S.J. Klebanoff, and J.M. Harlan. 1986. Monoclonal antibody
defined functional epitopes on the adhesion promoting glycoprotein
complex (CD18) of human neutrophils. Blood 67: 1007-1013.

6\. Hickstein, D.D., R.M. Locksley, P.G. Beatty, A.J. Smith, D.M. Stone,
and R.K. Root. 1986. Monoclonal antibodies affecting human neutrophil
C3bi receptor. Blood 67: 1054-1062.

7\. Hickstein, D.D., A.J. Smith, P.G. Beatty, B.R. Schwartz, J.M.
Harlan, R.K. Root, and R.M. Locksley. 1987. Expression of leukocyte
adhesion-related glycoproteins during differentiation of HL-60
promyelocytic leukemia cells. J.Immunol. 138:513-519.

8\. Hickstein, D.D., J. Ozols, S.A. Williams, J.U. Baenzinger, R.M.
Locksley, and G.J. Roth. 1987. Isolation and characterization of the
receptor on human neutrophils that mediate cellular adherence. J. Biol.
Chem. 262: 5576-5580

9\. Hickstein, D.D., M.J. Hickey, and S.J. Collins. 1988.
Transcriptional regulation of the leukocyte adherence protein beta
subunit during human myeloid cell differentiation. J. Biol. Chem. 263:
13863-13867.

10\. Hickstein, D.D., M. Howard, L. Meuller, M.J. Hickey, and S.J.
Collins. 1988. Expression of the beta subunit of the human leukocyte
adherence receptor depends upon cell type and stage of differentiation.
J. Immunol. 141: 4313-4317.

11\. Hickstein, D.D., M.J. Hickey, J. Ozols, D.M. Baker, A.L. Back, and
G.J. Roth. 1989. cDNA sequence for the aM subunit of the human
neutrophil adherence receptor indicates homology to integrin alpha
subunits. Proc. Natl. Acad. Sci. U.S.A. 86: 257-261.

12\. Dudley, D., D.M. Baker, M.J. Hickey, and D.D. Hickstein. 1989.
Expression of surface antigen and mRNA for the CDllc (ax, p150) subunit
of the human leukocyte adherence receptor family in hematopoietic cells.
Biochem. Biophys. Res. Comm. 160: 346-353.

13\. Roth, G. J., M.J. Hickey, D.W. Chung, and D.D. Hickstein. 1989.
Circulating human blood platelets retain appreciable amounts of poly A
(+) RNA. Biochem. Biophys. Res. Comm. 160: 705-710.

14\. Hickstein, D.D., A.L. Back, and S.J. Collins. 1989. Regulation
expression of the CDllb and CD18 subunits of the neutrophil adherence
receptor during human myeloid differentiation. J. Biol. Chem. 264:
21812-21817.

15\. Back, A.L., W.W. Kwok, M. Adam, S.J. Collins, and D.D. Hickstein.
1990. Retroviral- mediated gene transfer of the leukocyte integrin CD18
subunit. Biochem. Biophys. Res. Comm. 171: 787-795.

16\. Hromas, R, S.J. Collins, D. Hickstein, W. Raskind, L.L. Deaven, P.
O\'Hara, F.S. Hagen, and K. Kaushansky. 1991. A retinoic acid-responsive
human zinc finger gene. MZF - 1, preferentially expressed in myeloid
cells. J. Biol. Chem. 266: 14183-14187.

17\. Back, A.L., K. Gollahon, and D.D. Hickstein. 1992. Regulation of
expression of the leukocyte integrin CDlla (LFA-1) molecule during
differentiation of HL-60 cells along the monocyte macrophage pathway. J.
Immunol. 148: 710-714.

18\. Back, A.L., W.W. Kwok, and D.D. Hickstein. 1992. Identification of
two molecular defects in a child with leukocyte adherence deficiency. J.
Biol. Chem. 267: 5482-5487.

19\. Hickstein, D.D., D.M. Baker, K.A. Gollahon, and A.L. Back. 1992.
Identification of the promoter of the myelomonocytic leukocyte integrin
CDllb (Mac -1). Proc. Natl. Acad. Sci. U.S.A. 89: 2105-2109.

20\. Albert, R.K., L. Embree, and D.D. Hickstein. 1992. Expression and
function of beta 2 integrins on alveolar macrophages from human and
nonhuman primates. Amer. J. Resp. Cell and Mol. Biol. 7:182-189.

21\. Cornwell, R.D., K.A. Gollahon, and D.D. Hickstein. 1993.
Description of the leukocyte function-associated antigen-1 (LFA-1 or
CD11a) promoter. Proc. Natl. Acad. Sci. U.S.A. 90:4221-4225.

22\. Back, A.L., M. Kerkering, D.M. Baker, T.R. Bauer, L.J. Embree, and
D.D. Hickstein. 1993. A point mutation associated with leukocyte
adhesion deficiency type I of moderate severity. Biochem. Biophy. Res.
Comm. 193: 912-918.

23\. Hickstein, D.D., E. Grunvald, G. Shumaker, D.M. Baker, A.L. Back,
L.J. Embree, E. Yee, and K.A. Gollahon. 1993. Transfected leukocyte
integrin CD11b/CD18 (Mac-1) mediates phorbol ester-activated, homotypic
cell:cell adherence in K562 cell line. BLOOD 82: 2537-2545.

24\. Bauer, T.R., W.R.A. Osborne, W.W. Kwok, and D.D. Hickstein. 1994.
Expression from leukocyte integrin promoters in retroviral vectors.
Human Gene Therapy 5:709-716.

25\. Park, J., K. Robertson, D.D. Hickstein, D. Hockenbery, S. Tsai, and
S.J. Collins. 1994. Dysregulated bcl-2 expression inhibits apoptosis but
not differentiation of retinoic acid-induced HL-60 granulocytes. BLOOD
84: 440-445.

26\. Back, A.L., K. East, and D.D. Hickstein. 1995. Leukocyte integrin
CD11b promoter directs expression in lymphocytes and granulocytes in
transgenic mice. BLOOD 85: 1017-1024.

27\. Ritchie, K.R., A. Aprikian, and D.D. Hickstein. 1995. The human
leukocyte integrin CD11a promoter directs expression in leukocytes in
transgenic mice. BLOOD 86:147-155.

28\. Bauer, T.R., A.D. Miller, and D.D. Hickstein. 1995. Improved
transfer of the leukocyte integrin CD18 subunit into hematopoietic cell
lines by using retroviral vectors having a gibbon ape leukemia virus
envelope. BLOOD 86:2379-2387.

29\. Schmits, R., T.M. Kundig, D.M. Baker, G. Schumaker, J.J.L. Simard,
G. Duncan, A. Wakeman, A. Shahinian, A.V. Heiden, P.S. Ohashi, T.W. Mak,
and D.D. Hickstein. 1996. LFA-1 deficient mice showed normal CTL
responses to virus but failed to reject immunogenic tumor. J. Exp. Med.
183:1415-1426.

30\. Kwiatkowski, B.A., L.J. Embree, K.A. Ritchie, and D.D. Hickstein.
1996. Human leukocyte integrin CD18 promoter directs low levels of
expression of a mutated human CD4 reporter gene in leukocytes of
transgenic mice. Biochem. Biophys. Res. Comm. 222: 601-606.

31\. Bauer, T.R., Jr., and D.D. Hickstein. 1997. Transduction of human
hematopoietic cells and cell lines using a retroviral vector containing
modified murine CD4 reporter gene. Human Gene Therapy 8:243-52.

32\. Malech, H.L., T.R. Bauer, and D.D. Hickstein. 1997. Prospects for
gene therapy of neutrophil defects. Seminars in Hematology 34:355-361.

33\. Bauer, T.R., Jr., B.R. Schwartz, W.C.Liles, H.D.Ochs, and
D.D.Hickstein. 1998. Retroviral-mediated gene transfer of the leukocyte
integrin CD18 into peripheral blood CD34+ cells derived from a patient
with leukocyte adhesion deficiency type I. BLOOD (Rapid Communication)
91:1520-1526.

34\. Kwiatkowski, B.A., L.S.Bastian, T.R.Bauer, S. Tsai, A.G.
Zielinska-Kwiakowska, and D.D.Hickstein. 1998. The ets family member Tel
binds to the Fli-1 oncoprotein and inhibits its transcriptional
activity. J. Biol. Chem. 273: 17525-17530.

35\. Yang, L., L.J. Embree, S.Tsai, and D.D. Hickstein. 1998.
Oncoprotein TLS interacts with serine-arginine (SR) proteins involved in
RNA splicing. J. Biol. Chem. (Commun) 273: 27761-27764.

36\. Aprikyan, A.G., K.A. Ritchie, D.F. Bowen-Pope, C.J. Norby-Slycord,
S. Conyers, S.H. Bartelmez, E. Sitnicka, and D.D. Hickstein. 1999. The
Tel/PDGFRB fusion gene produces a chronic myeloproliferative syndrome in
transgenic mice. Leukemia 13:1790-1803.

37\. Kijas, J.M.H., T.R. Bauer, S. Gafvert, S. Marklund, G.
Trowald-Wigh, A. Johannisson, A. Hedhammar, M. Binns, R.K. Juneja, D.D.
Hickstein, and L. Andersson. 1999. A missense mutation in the ß-2
integrin gene (ITGB2) causes canine leukocyte adhesion deficiency.
Genomics 61:101-107.

38\. Yang, L., L.J. Embree, and D.D.Hickstein. 2000. TLS/ERG leukemia
fusion protein inhibits RNA splicing mediated by serine-arginine
proteins. Mol. Cell. Biol. 20:3345-54.

39\. Yang, L., H.A. Chansky, and D.D. Hickstein. 2000. EWS/Fli-1 fusion
protein interacts with hyperphosphorylated RNA polymerase II and
interferes with serine-arginine protein mediated RNA splicing. J. Biol.
Chem. 275: 37612-37618.

40\. Bauer,T.R., and D.D. Hickstein. 2000. Gene therapy for leukocyte
adhesion deficiency. Curr. Opin. Mol. Ther. 2: 383-8.

41\. Kwiatkowski, B.A., A.G.Zielinska-Kwiatkowska, T.R.Bauer, and D.D.
Hickstein. 2000. ETS family member Tel antagonizes the Fli-1 phenotype
in hematopoietic cells. Blood Cells Mol. Dis. 26:84-90.

42\. Chansky, H.A., D.D. Hickstein, and L. Yang. 2001. Oncogenic TLS/ERG
and EWS/FLI-1 fusion proteins inhibit RNA splicing mediated by YB-1
protein. Cancer Res. 61:3586-3590.

43\. L. Yang, L. Xia, D.Y. Wu, H. Wang, H.A. Chansky, W.H. Schubach,
D.D. Hickstein, and Y. Zhang. 2002. Molecular cloning of ESET, a novel
histone H3-specific methyltransferase that interacts with transcription
factor ERG. Oncogene 21:148-152.

44\. J.M. Clinton, H.A. Chansky, D.D. O\'Dell, A. Zielinska-Kwiatkowska,
D.D. Hickstein, and L. Yang. 2002. Characterization and expression of
the human gene encoding two TLS-associated serine-arginine (TASR)
proteins. Gene 284:141-7.

45\. Creevy, K.E., T.R Bauer, L.M. Tuschong, L.J. Embree, L. Colenda, K.
Cogan, M.F. Starost, M.E. Haskins, and D.D. Hickstein. 2003. Canine
leukocyte adhesion deficiency colony for investigation of novel
hematopoietic therapies. Vet Immunol Immunopath 94:11-22.

46. Creevy, K.E., T.R. Bauer, L.M. Tuschong, L.J. Embree, A.
    Silverstone, J. Bacher, C. Romines, J. Garnier, M. Thomas, L.
    Colenda, and D.D. Hickstein. 2003. Mixed chimeric hematopoietic stem
    cell transplant reverses the disease phenotype in canine leukocyte
    adhesion deficiency. Vet Immunol and Immunopath 95:113-121.

47. Bauer, T.R., Y.C. Gu, K.E. Creevy, L.M. Tuschong, L. Embree, S.M.
    Holland, R.A. Sokolic, and D.D. Hickstein. 2004. Leukocyte adhesion
    deficiency in children and Irish setter dogs. Peds Res 55: 363-367.

48\. Bauer, T.R., Y.C. Gu, K.E. Creevy, R.E. Donahue, M.E. Metzker, L.M.
Tuschong, Y. Gu, L.J. Embree, T. Burkholder, J.D. Bacher, C. Romines,
M.L. Thomas, L. Colenda, and D.D. Hickstein. 2004. Very low levels of
donor CD18+ neutrophils following allogeneic hematopoietic stem cell
transplantation reverses the disease phenotype in canine leukocyte
adhesion deficiency. BLOOD 103: 3582-3589.

49\. Gu, Y.C., T.R. Bauer, M. Ackerman, C. Smith, M. Kehrli, M. Starost,
and D.D. Hickstein. 2004. The genetic immunodeficiency disease leukocyte
adhesion deficiency in man, dog, cattle, and mouse. Comp Med 54:
364-373.

50\. Bauer, T.R. Jr., Y.C. Gu, L.T. Tuschong, T. Burkholder, J.D.
Bacher, M.F. Starost, R.E. Donahue, R.A. Sokolic, and D.D. Hick stein.
2005. Non-myeloablative hematopoietic stem cell transplantation corrects
the disease phenotype in the canine model of leukocyte adhesion
deficiency. Exp Heme 33(6): 706-712.

51\. Sokolic, R.S., T.R. Bauer, Y.C. Gu, M. Hai, L.M. Tuschong, T.
Burkholder, L. Colenda, J. Bacher, M.F. Starost, and D.D. Hickstein.
2005. Non-myeloablative conditioning with busulfan before matched
littermate bone marrow transplantation results in reversal of the
phenotype in canine leukocyte adhesion deficiency. Biol Blood Marrow
Transplant 11: 755-763.

52\. Gu, Y.C., T.R. Bauer, R.S. Sokolic, L.M. Tuschong, and D.D.
Hickstein. 2006. Conversion of the severe to the moderate deficiency
phenotype with donor leukocyte microchimerism in canine leukocyte
adhesion deficiency. Bone Marrow Transplant 37(6): 607-14.

53\. Engel, M.E., D.D. Hickstein, T.R. Bauer, C. Calder, B. Manes, and
H. Frangoul. 2006. Matched unrelated bone marrow transplantation with
reduced-intensity conditioning for leukocyte adhesion deficiency. Bone
Marrow Transplant 37:717-718.

54\. Burkholder, T.A., L. Colenda, L.M. Tuschong, M.F. Starost, T.R.
Bauer, and D.D. Hickstein. 2006. Reproductive capability in dogs with
canine leukocyte adhesion deficiency treated with non-myeloablative
conditioning prior to allogeneic hematopoietic stem cell
transplantation. BLOOD 108:1767-1769.

55\. Bauer, T.R., M. Hai, L.M. Tuschong, T.H. Burkholder, Y.C. Gu, R.A.
Sokolic, C. Feguson, C.E. Dunbar, and D.D. Hickstein. 2006. Correction
of the disease phenotype in canine leukocyte adhesion deficiency using
ex-vivo hematopoietic stem cell gene therapy. BLOOD 108:3313-20.

56\. Sabaawy, H., M. Azuma, L. Embree, H-J. Tsai, M. Starost, and D.D.
Hickstein. 2006. TEL-AML1 transgenic zebrafish model of precursor B-cell
acute lymphoblastic leukemia. Proc. Natl. Acad. Sci. U.S.A. Track 2
103:15166-71.

57\. Azuma, M., L.J. Embree, H. Sabaawy, and D.D. Hickstein. 2007. Ewing
Sarcoma Protein Ewsr1 Maintains Mitotic Integrity and Proneural Cell
Survival in the Zebrafish Embryo. PLosOne 10:e979.

58\. Bauer, TR, J.M. Allen, L.M. Tuschong, I.F. Khan, E.M. Olson, M.
Hai, T.H. Burkholder, Y.C. Gu, D.W. Russell^,^ and D.D. Hickstein. 2008.
Successful treatment of canine leukocyte adhesion deficiency by foamy
virus vectors. Nat. Med. 14: 93-97.

[Book and Book Chapters]{.underline}

1\. Hickstein, D.D., and R.K. Root, 1985. Polymorphonuclear leukocytes:
function and role in sepsis. In: Contemporary Issues in Infectious
Diseases, Churchill Livingston, pp.61-82.

2\. Malech, H.L and D.D. Hickstein. 2007. Genetics, Biology and Clinical
Management of

Myeloid Cell Primary Immune Deficiencies: Chronic Granulomatous Disease
and Leukocyte Adhesion Deficiency. Current Opinion Hematology/Oncology
14:29-36.