# CURRICULUM VITAE

**Academic Education and Appointments:**

Apr. 1981-Mar. 1987 Faculty of Medicine,

Kyoto University,

Awarded the degree of M.D.

Apr. 1987-May 1988 Residency, Dept. of Radiology and

Nuclear Medicine, Kyoto University

Hospital, Kyoto, Japan

June 1988-Mar. 1991 Residency, Dept. of Radiology, Kyoto

National Hospital, Kyoto, Japan

Apr. 1991-Mar. 1995 Postgraduate course, Dept. of Nuclear

Medicine and Diagnostic Imaging, Faculty of Medicine, Kyoto University,
Kyoto, Japan

PhD was awarded at March 23^rd^ 1995.

Apr. 1995-July 1995 Clinical stuff physician, Dept. of Nuclear

Medicine and Diagnostic Imaging, Faculty of Medicine, Kyoto University,
Kyoto, Japan

July 1995-Oct. 1998 Visiting (Fogarty) fellow, Nuclear Medicine
Department

National Institutes of Health, Bethesda, MD, USA

> Nov.1998- June 2001 Assistant professor, Dept. of Diagnostic and
> Interventional Imagiology, Kyoto University, Kyoto, Japan
>
> June 2001- June 2004 Senior (visiting) fellow, Metabolism Branch,
> CCR/NCI,
>
> National Institutes of Health, Bethesda, MD, USA
>
> June 2004- current Chief (Staff) Scientist, NCI Molecular Imaging
> Program, CCR/NCI/ National Institutes of Health, Bethesda, MD, USA

**Present Affiliation:**

Hisataka Kobayashi, MD. PhD., Chief, Staff scientist,

Molecular Imaging Program, Center for Cancer Research, National Cancer
Institute,

National Institutes of Health,

Bldg. 10, Room 1B40, MSC1088,

10 Center Dr., Bethesda, MD 20892-1088, USA

Telephone: 1-301-435-4086

Fax: 1-301-402-3191

E-mail: Kobayash@mail.nih.gov

**Certification**:

Japanese National Board of Medicine

The Board of the Japanese College of Radiology

The Board of Japan Gastroenterological Endoscopy Society

The Specialty of the Japanese Society of Nuclear Medicine

**Membership of Academic Societies:**

Radiological Society of North America

Society of Nuclear Medicine (A member of the program committee for the
annual meeting of SNM In 1998 and 1999)

International Society of Magnetic Resonance in Medicine (A member of the
program committee for the annual meeting 2005)

Active member of American Association of Cancer Research

American Chemical Society

Society of Molecular Imaging

Japan Radiological Society

Japanese Society of Nuclear Medicine

Japanese Cancer Association

Japan Gastroenterological Endoscopy Society

**Awards:**

*International.*

1\. AACR-Pharmagen Young Investigator Award (89th Annual Meeting of
American Association of Cancer Research) March 1998, New Orleans.
"Favorable effects of glycolate-conjugation on the biodistribution of
Humanized anti-Tac Fab fragment"

2\. The \"Alavi-Mandell\" award from the Society of Nuclear Medicine
2000, St. Louis, "Methods to avoid the adverse effect of circulating
antigen on biodistribution of 125I anti-Tac dsFv: Preinjection of intact
antibody vs clearance of antigen with avidin-biotin system"

3\. Selected best abstract in 2004 AACR (95^th^ Annual Meeting of
American Association of Cancer Research) March 2004, Orlando, FL.
"Lymphatic Drainage Imaging of the Breast Cancer in Mice using the
Micro-Magnetic Resonance Mammo-Lymphangiography using a Nano-size
Contrast Agent"

4\. 2004 Fellow award of research excellence in NIH, Bethesda, USA

5\. 2004 Technology transfer award in NCI/NIH, Bethesda, USA

6\. Certificate of Merit in 2004 RSNA meeting, December 2004, Chicago,
IL.

*Domestic (Japan).*

1\. The Annual research award (6th Japan Geriatric Digestive Disease,
Annual Conference) July 1990, Nagoya.

2\. 10^th^ Konica Imaging Science Award, Feb. 2000, Tokyo

3\. 19^th^ Shimazu Science Award, Young investigator award, Feb. 2000,
Kyoto,

4\. The 38^th^ Award of Japanese Society of Nuclear Medicine, Oct. 2000,
Kobe.

# International Patents

1\. A novel liver dendrimer-based MRI contrast agent;
DAB-Am64-(1B4M-Gd)~64~ (Filed; DHHS Reference No. E-240-2001)

2\. Renal tubular functional MRI contrast agents (Issued; US patent No.
***6,852,842***)

3\. New MRI method to detect the sentinel node of breast cancer (Filed;
DHHS Reference No. E-338-2003)

4\. Method for tumor treatment using dendrimer conjugates (Filed; DHHS
Reference No. E-107-2005 /0-US-01)

5\. Target detection with fluorescence imaging and target photo-dynamic
therapy of micro-cancer nodules disseminated in the peritoneal space.
(Filed; HHS Reference No. E-335-2005/0-US-01)

6\. Activatable fluorescence probe for molecular imaging and targeting
therapy. (in application)

**Newspaper/TV articles**

1\. 9/30/2000 Kyoto Shinbun (regional newspaper) "Development of
micro-MRI to investigate tumor vasculature using novel MRI
macromolecular contrast agents"

2\. 10/14/2000 Yomiuri Shinbun (national newspaper) "New method to
investigate tumor angiogenesis with micro-MRI and novel MRI
macromolecular contrast agents"

3\. 5/30/2001 Kyoto Shinbun (regional newspaper) "Metastatic tumors in
the liver with 0.3mm diameter could be detected by micro-MRI technique
with a novel liver MRI contrast agent "

4\. 6/1/2001 Kobe Shinbun (regional newspaper) "Metastatic tumors in the
liver with 0.3mm diameter could be detected by micro-MRI technique with
a novel liver MRI contrast agent "

5\. 3/30/2004 NCI Cancer Bulletin "Striking Results Achieved in Lymph
System Imaging Using MRI and Nano-Scale Contrast Agent"
http://www.cancer.gov/NCICancerBulletin/ NCI_Cancer_Bulletin_033004.pdf
http:// www.nci.nih.gov/NCICancerBulletin/
NCI_Cancer_Bulletin_033004.pdf

6\. 5/10/04 Reuters/Health (USA/UK)"Micro MRI tracks breast cancer
metastasis, in mice."

7\. 5/15/04, p318, Science News "Nanoparticles could mark spots for
surgery."

8\. May 2004, Oncology News International. vol. 13 No. 5, p. 57,
"Nanomolecular Contrast Agent May Aid in SLN Dissection."

9\. 6/10/2004 Oncology Times, p70-72 "Proteonomic technology Aims to
Move Diagnosis Forward".

10\. 2004/9 p6. Molecular Imaging Outlook "Nano-sized dendrimer MR
contrast tracks lymphatic drainage of breast cancer"
http://www.dimag.com/molecularimagingoutlook/2004sep/05.shtml

11\. 9/30/2004 Toronto Star "Intense enquiry into ways to stop
tumoursResearchers look at ways to inhibit cancer cell growth"
http://www.thestar.com/NASApp/cs/ContentServer?pagename=thestar/Layout/Article_Type1&c=Article&cid=1096409409586&call_pageid=1065003745048&col=1065003745093&tacodalogin=no

12\. 2005/2 Nature Medicine News Article, "the recent evolution of
diagnostic imaging systems"

13\. 2005/7 CCR Frontiers in Science, Vol. 4 p9-10. "Lymphatic Drainage
Imaging of Breast Cancer in Mice by Micro-Magnetic Resonance
Lymphangiography using a Nano-size Paramagnetic Contrast Agent."
http://ccr.cancer.gov/news/frontiers/july2005/lymphatic_drainage.html

14\. 2007/3/15 NIH news, "**New Molecular Imaging Compound Pinpoints
Cancer Spread in Mice**" http://www.nih.gov/news/pr/mar2007/nci-15.htm

15\. 2007/3/20 NCI Cancer Bulletin p.4 "New Molecular Imaging Compound
Pinpoints Metastases in Mice"
http://www.cancer.gov/ncicancerbulletin/NCI_Cancer_Bulletin_032007/page4

16\. 2007/4/7 NIH record, Digest "**Glow-in-the-Dark Cells**"
http://www.nih.gov/nihrecord/04_06_2007/04062007_Record.pdf

17\. 2007/4/15 NCI News, "**New Molecular Imaging Compound Pinpoints
Cancer Spread in Mice**"
http://www.cancer.gov/newscenter/pressreleases/FluorescenceOvarian

18\. 2007/4/30 Mainichi Shinbun (national newspaper) "Glow cancer cells"
Cover story.

19\. 2007/4/30 Sankei Shinbun (national newspaper) "Target-cell specific
detection of cancer"

20\. 2007/4/30 Chunichi Shinbun (regional newspaper) "Target-cell
specific detection of cancer" Cover story.

21\. 2007/4/30/ Kobe Shinbun (regional newspaper) "Target-cell specific
detection of cancer"

22\. 2007/4/30/ Hokkaido Mainichi Shinbun (regional newspaper) "Glow
cancer cells"

23\. 2007/5/1/ Nippon Television, News Zero (National TV broadcast)
"Cancer cell specific imaging drug"
http://www1.ntv.co.jp/zero/weekly-blog/

24\. 2007/7/14 Mainichi Shinbun (national newspaper) "Light can diagnose
multiple cancers"

25\. 2007/8/11 Jiji Tsushin (National news source) "Diagnosis of cancer
sub-types with multiple colors"

26\. 2007/9 Biophotonics International "Quantum Dots Carry Light into
Remote Biological Regions" p30-32.