+---------------------------+------+------+------+------+-----+-----+
| **Name(s) of Specific     | **P  | *    | *    | *    | **  | **  |
| Application Risk Team     | oint | *1** | *2** | *3** | 4** | 5** |
| Members:**                | V    |      |      |      |     |     |
|                           | alue |      |      |      |     |     |
| P. Thanos, R. Colichio,   | →**  |      |      |      |     |     |
| J. Dhawan, C. Du, A.      |      |      |      |      |     |     |
| Emrick                    | **P  |      |      |      |     |     |
|                           | aram |      |      |      |     |     |
| 8/24/06                   | eter |      |      |      |     |     |
|                           | ↓**  |      |      |      |     |     |
+---------------------------+------+------+------+------+-----+-----+
| **Job Title: "Rodent Use  | *    | *    | **   | *    | **[ | *   |
| in Research"**            | *Fre | *[\< | [\<] | *[\< | \<] | *\> |
|                           | quen | ]{.u | {.un | ]{.u | {.u | onc |
| **Job Number or Job       | cy** | nder | derl | nder | nde | e/s |
| Identifier: DJ-JRA-03A**  |      | line | ine} | line | rli | hif |
|                           | **(  | }onc | once | }onc | ne} | t** |
|                           | B)** | e/ye | /mon | e/we | onc |     |
|                           |      | ar** | th** | ek** | e/s |     |
|                           |      |      |      |      | hif |     |
|                           |      |      |      |      | t** |     |
+---------------------------+------+------+------+------+-----+-----+
| **Job Description:**      | **Se | **F  | *    | **   | **P | *   |
|                           | veri | irst | *Med | Lost | art | *De |
| This JRA covers the       | ty** | Aid  | ical | Ti   | ial | ath |
| routine experimental use  |      | On   | Tre  | me** | Dis | or  |
| of rodents by research    | **(  | ly** | atme |      | abi | Per |
| staff.                    | C)** |      | nt** |      | lit | man |
|                           |      |      |      |      | y** | ent |
|                           |      |      |      |      |     | Dis |
|                           |      |      |      |      |     | abi |
|                           |      |      |      |      |     | lit |
|                           |      |      |      |      |     | y** |
+---------------------------+------+------+------+------+-----+-----+
| **Training Procedures     | **   | **   | **Un | **Po | **P | **M |
| List (Optional):**        | Like | Very | like | ssib | rob | ult |
|                           | liho | Un   | ly** | le** | abl | ipl |
| LAT 1 Training for BLAF   | od** | like |      |      | e** | e** |
| rodent handling.          |      | ly** |      |      |     |     |
|                           | **(  |      |      |      |     |     |
|                           | D)** |      |      |      |     |     |
+---------------------------+------+------+------+------+-----+-----+
| Approved by:              |      |      |      |      |     |     |
|                           |      |      |      |      |     |     |
| Date: R. Colichio Rev. #: |      |      |      |      |     |     |
| 0 Date: 9/10/06           |      |      |      |      |     |     |
+---------------------------+------+------+------+------+-----+-----+
| **Stressors (if           |      | **Re |      |      | *   |     |
| applicable, please list   |      | ason |      |      | *Co |     |
| all) :**                  |      | for  |      |      | mme |     |
|                           |      | Revi |      |      | nts |     |
| **None**                  |      | sion |      |      | :** |     |
|                           |      | (if  |      |      |     |     |
|                           |      | ap   |      |      |     |     |
|                           |      | plic |      |      |     |     |
|                           |      | able |      |      |     |     |
|                           |      | ):** |      |      |     |     |
+---------------------------+------+------+------+------+-----+-----+

<table>
<colgroup>
<col style="width: 12%" />
<col style="width: 10%" />
<col style="width: 2%" />
<col style="width: 2%" />
<col style="width: 2%" />
<col style="width: 2%" />
<col style="width: 4%" />
<col style="width: 16%" />
<col style="width: 2%" />
<col style="width: 2%" />
<col style="width: 2%" />
<col style="width: 2%" />
<col style="width: 2%" />
<col style="width: 3%" />
<col style="width: 10%" />
<col style="width: 2%" />
<col style="width: 2%" />
<col style="width: 2%" />
<col style="width: 2%" />
<col style="width: 2%" />
<col style="width: 3%" />
<col style="width: 3%" />
</colgroup>
<thead>
<tr class="header">
<th></th>
<th></th>
<th colspan="5">Without Controls</th>
<th colspan="7"><strong>Before Additional Controls</strong></th>
<th colspan="7">After Additional Controls</th>
<th></th>
</tr>
<tr class="odd">
<th><strong>Activity</strong></th>
<th><strong>Hazard</strong></th>
<th><blockquote>
<p># of People A</p>
</blockquote></th>
<th><blockquote>
<p>Frequency B</p>
</blockquote></th>
<th><blockquote>
<p>Severity C</p>
</blockquote></th>
<th><blockquote>
<p>Likelihood D</p>
</blockquote></th>
<th><blockquote>
<p>Risk* AxBxCxD</p>
</blockquote></th>
<th><strong>Control(s)</strong></th>
<th><blockquote>
<p><strong>Stressor</strong></p>
</blockquote></th>
<th><blockquote>
<p><strong># of People A</strong></p>
</blockquote></th>
<th><blockquote>
<p><strong>Frequency B</strong></p>
</blockquote></th>
<th><blockquote>
<p><strong>Severity C</strong></p>
</blockquote></th>
<th><blockquote>
<p><strong>Likelihood D</strong></p>
</blockquote></th>
<th><blockquote>
<p><strong>Risk* AxBxCxD</strong></p>
</blockquote></th>
<th><h1 id="controls-added-to-reduce-risk">Control(s) Added to Reduce
Risk</h1></th>
<th><h1 id="stressors">Stressors</h1></th>
<th><blockquote>
<p># of People A</p>
</blockquote></th>
<th><blockquote>
<p>Frequency B</p>
</blockquote></th>
<th><blockquote>
<p>Severity C</p>
</blockquote></th>
<th><blockquote>
<p>Likelihood D</p>
</blockquote></th>
<th><blockquote>
<p>Risk* AxBxCxD</p>
</blockquote></th>
<th><blockquote>
<p>% Risk Reduction</p>
</blockquote></th>
</tr>
</thead>
<tbody>
<tr class="odd">
<td>Handling of rodents when removing or returning between BLAF and
research area.</td>
<td>Infection from Bite or scratch or contact with body fluids, scratch
from cage ,allergens, back injury from repetitive lifting,</td>
<td>1</td>
<td>5</td>
<td>3</td>
<td>3</td>
<td>45</td>
<td>BLAF Training, serology testing, special shipping caging, PPE,
carts.</td>
<td>N</td>
<td>1</td>
<td>5</td>
<td>1</td>
<td>2</td>
<td>10</td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr class="even">
<td>Anesthetizing rodents using controlled substances.</td>
<td>Bites/scratches, needlestick or contact with body fluids,
allergens.</td>
<td>1</td>
<td>5</td>
<td>3</td>
<td>3</td>
<td>45</td>
<td>Training, PPE (gloves), security for controlled subs, QA</td>
<td>N</td>
<td>1</td>
<td>5</td>
<td>1</td>
<td>2</td>
<td>10</td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr class="odd">
<td>Anesthetizing rodents using gas (ie; isoflurane or halothane).</td>
<td>Bites/scratches, needlestick or contact with body fluids. Exposure
to waste anesthesia gas.</td>
<td>1</td>
<td>5</td>
<td>3</td>
<td>3</td>
<td>45</td>
<td>PPE, scavenger, fume hood, comp gas training, BLAF training.</td>
<td>N</td>
<td>1</td>
<td>5</td>
<td>1</td>
<td>1</td>
<td>5</td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr class="even">
<td>Performing invasive procedures on live rodents (perfusions,
intubations, surgery)</td>
<td>Bites/scratches, needlestick or contact with body fluids, cuts from
sharp surgical instruments.</td>
<td>1</td>
<td>5</td>
<td>3</td>
<td>3</td>
<td>45</td>
<td>Training, PPE (gloves, sterile eqpt), chemical restraints</td>
<td>N</td>
<td>1</td>
<td>5</td>
<td>1</td>
<td>1</td>
<td>5</td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr class="odd">
<td>Injecting rodents with drugs or chemotherapeutic agents.</td>
<td>Bites/scratches, needlestick or contact with body fluids, allergens.
Adverse reaction to chemotherapeutic agent.</td>
<td>1</td>
<td>5</td>
<td>3</td>
<td>3</td>
<td>45</td>
<td>PPE, fume hood, BLAF training.</td>
<td>N</td>
<td>1</td>
<td>5</td>
<td>1</td>
<td>1</td>
<td>5</td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr class="even">
<td>Injecting rodents with dispersible radioisotopes.</td>
<td>Infection from Bite or scratch or contact with body fluids, scratch
from cage ,allergens, radioactive contamination.</td>
<td>1</td>
<td>5</td>
<td>3</td>
<td>3</td>
<td>45</td>
<td>Training, RWP, RCD Surveys, Shielding as per RWP.</td>
<td>N</td>
<td>1</td>
<td>5</td>
<td>1</td>
<td>1</td>
<td>5</td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr class="odd">
<td>Conducting behavioral studies</td>
<td>Infection from Bite or scratch or contact with body fluids, scratch
from cage ,allergens, back injury from repetitive lifting,</td>
<td>1</td>
<td>5</td>
<td>3</td>
<td>5</td>
<td>75</td>
<td>Training, PPE (gloves), containment</td>
<td>N</td>
<td>1</td>
<td>5</td>
<td>1</td>
<td>2</td>
<td>10</td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr class="even">
<td>Euthanasia of rodents.</td>
<td>Contact with body fluids, cuts from sharp surgical instruments,
allergic reaction to dander or rodent urine protein allergens.</td>
<td>1</td>
<td>3</td>
<td>3</td>
<td>3</td>
<td>27</td>
<td>Training, PPE, scavengers, dessicator</td>
<td>N</td>
<td>1</td>
<td>3</td>
<td>1</td>
<td>2</td>
<td>6</td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr class="odd">
<td>Performing necropsy or invasive procedures on deceased rodents,
tissue/fluid sample collection.</td>
<td>Contact with body fluids, cuts from sharp surgical instruments,
allergic reaction to dander or rodent urine protein allergens.</td>
<td>1</td>
<td>3</td>
<td>1</td>
<td>2</td>
<td>6</td>
<td>Training, PPE</td>
<td>N</td>
<td>1</td>
<td>3</td>
<td>1</td>
<td>1</td>
<td>3</td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr class="even">
<td colspan="22"><strong>Further Description of Controls Added to Reduce
Risk:</strong></td>
</tr>
</tbody>
</table>

  ------------- ---------------- ---------------- -------------- ----------------- -----------------
  **\*Risk:**   **0 to 20**      **21 to 40**     **41-60**      **61 to 80**      **81 or greater**

                **Negligible**   **Acceptable**   **Moderate**   **Substantial**   **Intolerable**
  ------------- ---------------- ---------------- -------------- ----------------- -----------------