**List of Published Literature**

**Relied on in Issuing the FR Notice on Doxycycline**

**and Penicillin G Procaine Administration**

**for Inhalational Anthrax (Post-Exposure)**

1\. Aach, R., and J. Kissane, eds., "A seventeen-year-old girl with
fatty liver of pregnancy following tetracycline therapy," Stenographic
Report of a Clinicopathologic Conference, *American Journal of
Medicine*, 43:274-283, 1967.

2\. Abramova, F. A., et al., "Pathology of inhalational anthrax in 42
cases from the Sverdlovsk outbreak of 1979," *Proceedings of the
National Academy of Sciences of the United States of America*,
90:2293-2294, 1993.

3\. Abramowicz, M. et al., \"Levels of penicillin in serum of newborn
infants,\" *American Journal of Diseases in Children*, 111:267-272,
1966.

4\. Akova, M. et al., \"Quinolones in treatment of human brucellosis:
comparative trial of ofloxacin-rifampin versus doxycycline-rifampin,\"
*Antimicrobial Agents & Chemotherapy*, 37:1831-1834, 1993.

5\. American Academy of Pediatrics, Committee on Infectious Diseases,
"Policy statement: recommendations for the prevention of pneumococcal
infections, including the use of pneumococcal conjugate vaccine
(Prevnar), pneumococcal polysaccharide vaccine, and antibiotic
prophylaxis," *Pediatrics*, 106:362-366, 2000.

6\. Andriole, V. T. et al., \"Penicillin G Procaine,\" in *Current
Infectious Disease Drugs*, 1st ed., Philadelphia: Current Medicine,
1996, pp. 96-97.

7\. Ariza, J. et al., \"Treatment of human brucellosis with doxycycline
plus rifampin or doxycycline plus streptomycin: randomized, double-blind
study,\" *Annals of Internal Medicine*, 117:25-30, 1992.

8\. Bhagavan, B. S. et al., \"Long-term use of tetracycline,\" *Journal
of the American Medical Association*, 247:2780, 1982.

9\. Bolme, P. et al., \"Malnutrition and pharmacokinetics of penicillin
in Ethiopian children,\" *Pharmacology and Toxicology*, 76:259-262,
1995.

10\. Boston Collaborative Drug Surveillance Program, "Tetracycline and
drug-attributed rises in blood urea nitrogen: A report from the Boston
Collaborative drug surveillance program," *Journal of the American
Medical Association*, 220:377-379, 1972.

11\. Brachman, P. S., \"Inhalation anthrax,\" *Annals of the New York
Academy of Sciences*, 353:83-93, 1980.

12\. Brachman, P. S. et al., \"An epidemic of inhalation anthrax: the
first in the twentieth century; II. Epidemiology,\" *American Journal of
Hygiene*, 72:6-23, 2001.

13\. Brown, S. T., \"Therapy for nonvenereal treponematoses: review of
the efficacy of penicillin and consideration of alternatives,\" *Reviews
of Infectious Diseases*, 7 Suppl 2:S318-S326, 1985.

14\. Cabellos, C. et al., \"Current usefulness of procaine penicillin in
the treatment of pneumococcal pneumonia,\" *European Journal of Clinical
Microbiology and Infectious Diseases*, 17:265-268, 1998.

15\. Campistron, G. et al., \"Pharmacokinetics and bioavailability of
doxycycline in humans,\" *Arzneimittel-Forschung (Aulendorf),*
36:1705-1707, 1986.

16\. Carson, J. L. et al., \"Acute liver disease associated with
erythromycins, sulfonamides, and tetracyclines,\" *Annals of Internal
Medicine*, 119: 576-583, 1993.

17\. Ceccarelli, G. et al., \"Pharmacokinetic study of doxycycline in
children,\" *Chemotherapy*, 16:1-10, 1971.

18\. Cisneros, J. M. et al., \"Multicenter prospective study of
treatment of *Brucella melitensis* Brucellosis with doxycycline for 6
weeks plus streptomycin for 2 weeks,\" *Antimicrobial Agents &
Chemotherapy*, 34:881-883, 1990.

19\. Colvin, B., M. Rogers, and C. Layton, \"Benzylpenicillin-induced
leucopenia: Complication of treatment of bacterial endocarditis,\"
*British Heart Journal*, 36:216-219, 1974.

20\. Corbett, G. M., D. J. Perry, and T. R. D. Shaw. \"Penicillin
induced leukopenia,\" *New England Journal of Medicine*, 307:1642-1643,
1982.

21\. Crowe, G. et al., \"Acceptability and compliance with daily
injections of procaine penicillin in the outpatient treatment of
syphilis-treponemal infection,\" *Sexually Transmitted Diseases*,
24:127-130, 1997.

22\. Council on Drugs, "Evaluation of a new antibacterial agent:
Doxycycline monohydrate and doxycycline hyclate (Vibramycin)," *Journal
of the American Medical Association*, 209:549-550, 1969.

23\. Dattwyler, R. J. et al., \"Ceftriaxone compared with doxycycline
for the treatment of acute disseminated Lyme disease,\" *New England
Journal of Medicine*, 337:289-294, 1997.

24\. Del Rosso, J. Q., \"Systemic therapy for rosacea: focus on oral
antibiotic therapy and safety,\" *Cutis,* 66 Suppl 4:7-13, 2000.

25\. Dittert, L. W. et al., \"Pharmacokinetic interpretation of
penicillin levels in serum and urine after intravenous administration,\"
*Antimicrobial Agents and Chemotherapy*, 9:42-48, 1969.

26\. Dixon, T. C. et al., \"Anthrax,\" *New England Journal of
Medicine*, 341:815-826, 1999.

27\. Doganay, M., and N. Aydin, \"Antimicrobial susceptibility of
*Bacillus anthracis*,\" *Scandinavian Journal of Infectious Diseases*,
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28\. Dunlop, E. M., S. S. Al Egaily, and E. T. Houang. \"Penicillin
levels in blood and CSF achieved by treatment of syphilis,\" *Journal of
the American Medical Association*, 241:2538-2540, 1979.

29\. Durack, David D., and Paul D. Hoeprich, "Infective Endocarditis,\"
in *Infectious Diseases: A Modern Treatise of Infectious Processes*, ed.
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Lippincott Company, 1989. pp. 1237-1253.

30\. Ellingson, H. V., P. J. Kadull, and H. L. Howe C. Bookwalter,
\"Cutaneous anthrax: Report of twenty-five cases,\" *Journal of the
American Medical Association*, 131:1105-1108, 1946.

31\. Fanning, W. L., D. W. Gump, and R. A. Sofferman, \"Side effects of
minocycline: a double-blind study,\" *Antimicrobial Agents and
Chemotherapy*, 11:712-717, 1977.

32\. Fernandez-Obregon, A. C., \"Azithromycin for the treatment of
acne,\" *International Journal of Dermatology*, 39:45-50, 2000.

33\. Friedlander, A. M. et al., \"Postexposure prophylaxis against
experimental inhalation anthrax,\" *Journal of Infectious Diseases*,
167:1239-1243, 1993.

34\. Galpin, J. E. et al., \"\"Pseudoanaphylactic\" reactions from
inadvertent infusion of procaine penicillin G,\" *Annals of Internal
Medicine*, 81:358-359, 1974.

35\. Garraffo, R. et al., "Effects of rifampicin on the pharmacodynamics
of doxycycline," *Pathologie Biologie (Paris),* 35:746-749, 1987.

36\. Gaston, M. H. et al., \"Prophylaxis with oral penicillin in
children with sickle cell anemia. A randomized trial,\" *New England
Journal of Medicine*, 314:1593-1599, 1986.

37\. Geraci, J. E., and W. J. Martin. \"Antibiotic therapy of bacterial
endocarditis: IV. Successful short-term (two weeks) combined
penicillin-dihydrostreptomycin therapy,\" *Circulation*, 8:494-509,
1953.

38\. Geraci, J. E., \"Antibiotic therapy of bacterial endocarditis,\"
*Medical Clinics of North America*, 42:1101-1140, 1958.

39\. Ginsburg, C. M., G. H. McCracken Jr., and T. C. Zweighaft, \"Serum
penicillin concentrations after intramuscular administration of
benzathine penicillin G in children,\" *Pediatrics*, 69:452-454, 1982.

40\. Glassman, H. N., \"World incidence of anthrax in man.\" *Public
Health Report*, 73:22-24, 1958.

41\. Gochenour, W. S. Jr., C. A. Gleiser, and W. D. Tigertt,
\"Observations on penicillin prophylaxis of experimental inhalation
anthrax in the monkey,\" *Journal of Hygiene*, 60:29-33, 1962.

42\. Gold, H., \"Anthrax: A report of one hundred seventeen cases,\"
*Archives of Internal Medicine*, 96:387-396, 1955.

43\. Gold, H., \"Aureomycin in the treatment of anthrax,\" *American
Journal of Medicine*, 8:31-33, 1950.

44\. Gold, H., \"Treatment of anthrax,\" *Federation Proceedings*,
26:1563-1568, 1967.

45\. Gold, H., and W. P. Boger, \"Newer antibiotics in the treatment of
anthrax,\" *New England Journal of Medicine*, 244:391-394, 1951.

46\. Gonciarz, Z. et al., \"Plasma penicillin-G parameters in man after
intraduodenal or intramuscular administration,\" *International Journal
of Clinical Pharmacology, Therapy, and Toxicology*, 24:622-624, 1986.

47\. Green, R. L. et al., \"Elevated plasma procaine concentrations
after administration of procaine penicillin G,\" *New England Journal of
Medicine*, 291:223-226, 1974.

48\. Griffin, J. R., R. H. Shanahan, and C. E. DeAngelis, \"Treatment of
cutaneous anthrax with penicillin,\" *New York State Journal of
Medicine*, 48:1718-1721, 1948.

49\. Grossman, E. R. \"Tetracycline and staining of the teeth,\"
*Journal of the American Medical Association*, 255:2442-2443, 1986.

50\. Heaney D., and G. Eknoyan, \"Minocycline and doxycycline kinetics
in chronic renal failure,\" *Clinical Pharmacology and Therapeutics*,
24:233-239, 1978.

51\. Henderson, D. W., S. Peacock, and F. C. Belton, \"Observations on
the prophylaxis of experimental pullmonary anthrax in the monkey,\"
[Journal of Hygiene]{.underline}, 54:28-36, 1956.

52\. Hoigne, R. et al., \"Penicillins,\" in *Meyler's Side Effects of
Drugs*, ed. M. N. G. Dukes, 12th ed., Amsterdam: Elsevier, 1992, pp.
600-622.

53\. Hoigne, R. et al., \"Penicillins, Cephalosporins and Other
Beta-Lactam Antibiotics,\" in *Meyler's Side Effects of Drugs,* ed. M.
N. G. Dukes, 12th ed. Amsterdam: Elsevier, 1992, pp. 593-599.

54\. Huang, N. N., and R. H. High, "Comparison of serum levels following
administration of oral and parenteral preparations of penicillin to
infants and children of various age groups," *Journal of Pediatrics*,
42:657, 1953.

55\. International Rheumatic Fever Study Group, "Allergic reactions to
long-term benzathine penicillin prophylaxis for rheumatic fever,"
*Lancet*, 37:1308-1310, 1991.

56\. Inglesby, T. V. et al., \"Anthrax as a biological weapon: medical
and public health management. Working Group on Civilian Biodefense,\"
*Journal of the American Medical Association*, 281:1735-1745 1999.

57\. John, A. B. et al., \"Prevention of pneumococcal infection in
children with homozygous sickle cell disease,\" *British Medical Journal
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58\. Jones, M. N. et al., \"Antibiotic prophylaxis for inhalation
anthrax,\" *Salisbury Medical Bulletin*, Suppl 87:127-128, 1996.

59\. Joorabchi, B., and E. Kohout. \"Apparent penicillin-induced arrest
of mature bone marrow elements,\" *British Medical Journal*, 2:26-27,
1973.

60\. Joshi, N., \"Doxycycline revisited,\" *Archives of Internal
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61\. Kaplan, M. M., \"Acute fatty liver of pregnancy,\" *New England
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62\. Karchmer, A. W. et al., \"Single-antibiotic therapy for
streptococcal endocarditis,\" *Journal of the American Medical
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63\. Kaye, D., \"Endocarditis,\" in *Cecil Textbook of Medicine*, ed. P.
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64\. Kees, F. et al., "The bioavailability of doxycycline."
*Arzneimittel-Forschung (Aulendorf)*, 40:1039-1043, 1990.

65\. Kelly, D. J. et al., \"Serum concentrations of penicillin,
doxycycline, and ciprofloxacin during prolonged therapy in Rhesus
monkeys,\" *Journal of Infectious Diseases*, 166:1184-1187, 1992.

66\. Kendall, C. E., \"Occupational anthrax in the United States,\"
*Journal of Occupational Medicine*, 1:174-177, 1959.

67\. Klein, J. O. et al., \"Levels of penicillin in serum of newborn
infants after single intramuscular doses of benzathine penicillin G,\"
*Journal of Pediatrics*, 82:1065-1968, 1973.

68\. Klempner, M. S. et al., \"Two controlled trials of antibiotic
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69\. Kunelis, C. T., J. L. Peters, and H. A. Edmonson, \"Fatty liver of
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70\. LaBoccetta, A. C., \"Anthrax: 36 human cases of the external type
treated successfully with penicillin,\" *American Journal of the Medical
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71\. Levy, P. Y. et al., \"Comparison of different antibiotic regimens
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72\. Lew, H. T., and S. W. French, \"Tetracycline nephrotoxicity and
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73\. Lightfoot, N. F., R. J. D. Scott, and P. C. B. Turnbull,
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74\. Maesen, F. P., B. I. Davies, and J. J. van den Bergh, \"Doxycycline
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75\. Malacoff, R. F., E. Frank, and V. T. Andriole, \"Streptococcal
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76\. Malmborg, A. S., \"Bioavailability of doxycycline monohydrate. A
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77\. Mandell, Gerald L., and William A. Petri, \"Antimicrobial Agents,\"
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78\. McCracken, G. H., Jr. et al., \"Clinical pharmacology of penicillin
in newborn infants,\" *Journal of Pediatrics*, 82:692-698, 1973.

79\. Menke, H. E., and L. Pepplinkhuizen, \"Letter: Acute non-allergic
reaction to aqueous procaine penicillin,\" *Lancet*, 2:723-724, 1974.

80\. Meselson, M. et al., "The Sverdlovsk anthrax outbreak of 1979,"
*Science*, 266:1202-1208, 1994.

81\. Misago, C. et al., \"Out-patient drug treatment of pneumonia among
children under two years of age in Fortaleza, Brazil,\" *Cadernos de
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82\. Muller-Vahl, H., \"Adverse reactions after intramuscular
injections,\" *Lancet*, 1:1050, 1983.

83\. Neu, H. C., \"A symposium on the tetracyclines: a major
appraisal,\" *Bulletin of the New York Academy of Medicine*, 54:141-155,
1978.

84\. Nguyen, V. X. et al., \"Effect of oral antacid administration on
the pharmacokinetics of intravenous doxycycline,\" *Antimicrobial Agents
and Chemotherapy*, 33:434-436, 1989.

85\. Odendaal, M. W. et al., \"The antibiotic sensitivity patterns of
*Bacillus anthracis* isolated from the Kruger National Park,\"
*Onderstepoort Journal of Veterinary Research*, 58:17-19, 1991.

86\. Olaison, L. et al., \"Incidence of beta-lactam-induced delayed
hypersensitivity and neutropenia during treatment of infective
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87\. Overturf, G. D., \"American Academy of Pediatrics. Committee on
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88\. Pai, V. B., and M. C. Nahata, \"Duration of penicillin prophylaxis
in sickle cell anemia: issues and controversies,\" *Pharmacotherapy*,
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89\. Patra, G. et al., \"Molecular characterization of Bacillus strains
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90\. Pelletier, Lawrence L., and Robert G. Petersdorf, "Infective
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91\. \"Penicillin G (Pen G),\" in *The Use of Antibiotics: A Clinical
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92\. \"Penicillin G Procaine,\" in *AHFS Drug Information 2000*, ed. G.
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93\. Pile, J. et al., "Anthrax as a Potential Biological Warfare Agent,"
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94\. Plotkin, S. A. et al., \"An epidemic of inhalation anthrax, the
first in the twentieth century I. Clinical features,\" *American Journal
of Medicine*, 29:992-1001, 1960.

95\. Raoult, D. et al., \"Treatment of Q fever endocarditis: comparison
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96\. Resnick, L., and L. Cohen, \"Antibiotic treatment of
penicillin-sensitive streptococcal endocarditis,\" *Journal of the
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97\. Ronaghy, H. A. et al., \"Penicillin therapy of human cutaneous
anthrax,\" *Current Therapeutic Research, Clinical and Experimental*,
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98\. Ross, J. M., \"The pathogenesis of anthrax following the
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99\. Rumble, R. H., M. S. Roberts, and A. R. Scott, \"The effects of
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*European Journal of Clinical Pharmacology*, 33:629-635, 1988.

100\. Saivin, S., and G. Houin, \"Clinical pharmacokinetics of
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101\. Sande, M. A., and W. M. Scheld, \"Combination antibiotic therapy
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102\. Sande, Merle A., and Peter M. Small, \"Infective Endocarditis,\"
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103\. Saux, M. C. et al., \"Pharmacokinetic study of doxycycline
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104\. Scheife, R. T., M. Levy, and D. J. Greenblatt, "Antimicrobial
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105\. Scheld, W. Michael, and Merle A. Sande, \"Cardiovascular
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106\. Schreiner, A., and A. Digranes, \"Pharmacokinetics of lymecycline
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107\. Seow, W. K., \"Enamel hypoplasia in the primary dentition: A
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108\. Shann, F., V. Linnemann, and M. Gratten, \"Serum concentrations of
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109\. Shapiro, L. E., S. R. Knowles, and N. H. Shear, \"Comparative
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110\. Shils, M. E., \"Renal disease and the metabolic effects of
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111\. Silber, T. J., and L. J. D\'Angelo, \"Panic attack following
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112\. Silber, T. J., and L. D\'Angelo, \"Psychosis and seizures
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113\. Simon, H. J. et al., \"Clinical pharmacology of antimicrobials in
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114\. Snavely, S. R. et al., \"Profound neutropenia associated with
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125\. Utley, P. M., J. B. Lucas, and T. E. Billings, \"Acute psychotic
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126\. Vancurik, J., \"Causes of the failure of antibiotic prophylaxis of
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127\. Wenk, R. E. et al., \"Tetracycline-associated fatty liver of
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130\. Wilson, W. R. et al., \"Short-term intramuscular therapy with
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131\. Wilson, W. R. et al., \"Short-term therapy for streptococcal
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132\. Wilson, W. R. et al., \"Antibiotic treatment of adults with
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135\. Wojcicki, J., W. Kalinowski, and B. Gawronska-Szklarz,
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