**CURRICULUM VITAE**

Amy Dodd Bradshaw

Assistant Professor

Ralph H. Johnson VA Medical Center

and

Medical University of South Carolina

114 Doughty St.

Charleston, S.C. 29425

\(843\) 792-4959

bradshad@musc.edu

**Education**

BA, Molecular Biology, Revelle College, UCSD, 12/86

PhD, Biochemistry and Neurobiology, UCSB, 10/95

**Professional Experience**

Teaching Assistant, Department of Biological Sciences, UCSB, Santa
Barbara, CA, 1988,90,91,92,93,94 (Introductory Biology and Cellular
Biochemistry).

Research Associate, Research Institute of Scripps Clinic, La Jolla CA,
6/86-6/88 (with Dr. Georg H. Fey).

Graduate Student, Neuroscience Research Institute and Department of
Biological Sciences, UCSB, Santa Barbara, CA 9/88-9/95 (with Dr. Dennis
O. Clegg).

Post-doctoral Fellow, Department of Biological Structure, University of
Washington, Seattle, WA 11/95-4/99 (with Dr. E. Helene Sage).

Post-doctoral Fellow, Department of Vascular Biology, The Hope Heart
Institute, Seattle, WA 4/99-7/01 (with Dr. E. Helene Sage).

Staff Scientist, Department of Vascular Biology, The Hope Heart
Institute, Seattle, WA 7/01-12/2002.

Assistant Professor, Gazes Cardiac Research Institute, Medical
University of South Carolina, Charleston, SC 1/2003- present.

Adjunct Assistant Professor, Department of Cell Biology and Anatomy,
Medical University of South Carolina, Charleston, SC 6/03- present.

Adjunct Assistant Professor, Department of Bioengineering, Clemson
University, Clemson, SC 3/04-present.

Adjunct Assistant Professor, College of Dental Medicine, Medical
University of South Carolina, Charleston, SC 3/08- present.

Research Health Scientist, Ralph H. Johnson Veteran's Administration
Medical Center, Charleston, SC 10/08- present

**Professional Activities**

Representative, Graduate Student Association, Department of Biological
Sciences, 1989-94

Member, American Society of Cell Biologists, 1998- present

Member, American Society of Matrix Biology 2001- present

Member, Heart Failure Society, 2007

IACUC Committee Member, Veteran's Administration (Charleston, SC) 2007

Councilor, American Society of Matrix Biology 2008-2011

**Awards and Scholarships**

Kirin Fellowship, Section of Biochemistry and Molecular Biology,
Department of Biological Sciences, UCSB, Santa Barbara, CA, 1988.

Neuroscience Biotechnology Training Fellowship, Neuroscience Research
Institute, UCSB, Santa Barbara, CA, 1991.

Regents Fellowship, Department of Biological Sciences, UCSB, Santa
Barbara, CA, Spring 1991.

ASCB Student Travel Award, ASCB, Bethesda, MD, 1994.

Excellence in Neuroscience Institute Award, NRI, UCSB, Santa Barbara CA,
1995.

Post-Doctoral Fellowship Award (F32), National Institutes of Health,
Bethesda MD, 1997-1999.

Top 10 Teachers in Graduate Core Class (2007), MUSC Graduate Students,
Selected from \~50 participating lecturers.

Young Investigator Travel Award, IDeA Conference, Washington DC, 2008

## Invited Talks

International Conference on Biology and Pathology of the Extracellular
Matrix, (2000) St. Louis MO.

Advanced Tissue Sciences, (2000) La Jolla CA.

University of Washington Engineered Biomaterials (UWEB), N.S.F. site
visit (2001) Seattle, WA.

Frontiers in Cardiovascular Research Conference, (2001) Seattle, WA.

Lehigh University, (2002) Bethlehem, PA.

Oregon Health Sciences University, (2002), Portland OR.

Gazes Cardiovascular Research Institute, (2002), Medical University of
South Carolina, Charleston, SC.

American Society for Cell Biology Annual Meeting (2002), San Francisco,
CA.

Hollings Cancer Research Center (2004), Charleston SC.

University of Missouri (2005), Columbia, MO

Gordon Research Conference: Collagen (2005), New London, NH.

American Society for Cell Biology Annual Meeting (2005), San Francisco,
CA

Proteins to Proteomics Symposium (2006), Irvine, CA

American Society for Matrix Biology (2006), Nashville, TN

University of Texas, Southwestern (2007), Dallas TX

Gordon Research Conference: Collagen (2007) New London, NH.

Southeastern Pharmacology Conference (2008) Charleston, SC

University of Toronto (2008) Toronto, ON

**Publications**

Abraham, L.J., **Bradshaw, A.D.,** Shiels, B.R., Northemann, W., Hudson,
G., and Fey, G.H. (1990) Hepatic transcription of the acute-phase
alpha-1-inhibitor III gene is controlled by a novel combination of
cis-acting regulatory elements, *Mol. Cell. Biol.*, **10**, 3483-3491.

Abraham, L.J., **Bradshaw, A.D**., Fletcher, R.G., and Fey, G.H. (1990)
Interleukin 6 is a negative regulator of the acute phase
alpha-1-inhibitor III gene, *Mol. Biol. Med.*, **7**, 261-271.

Abraham, L.J., **Bradshaw, A.D**., Northemann, W., and Fey, G.H. (1991)
Identification of a glucocorticoid response element contributing to the
constitutive expression of the rat liver alpha-1-inhibitor III gene, *J.
Biol. Chem.*, **266**, 18268-18275.

Orias, E., and **Bradshaw, A.D**. (1992) Stochastic developmental
variation in the ratio of allelic rDNAs among newly differentiated,
heterozygous macronuclei of Tetrahymena thermophila. *Dev. Genetics*
**13**, 87-93

**Bradshaw, A.D**., McNagny, K.M., Gervin, D.B., Cann, G.C., Graf, T.
and Clegg, D.O. (1995). Integrin α2β1 mediates interaction between
developing embryonic retinal cells and collagen. *Development* **121**,
3593-3602.

Smith B.S., **Bradshaw, A.D**., Choi, E., Rouselle, P., Wayner, E.A. and
Clegg, D.O. (1996). Human SY5Y neuroblastoma cell interactions with
laminin isoforms: Neurite outgrowth on LN-5 is mediated by integrin
α3β1. *Cell Adhesion and Comm.* **3**, 451-462.

Cann, G.C., **Bradshaw, A.D**., Gervin, D.B. and Clegg, D.O. (1996)
Widespread expression of β1 integrins in the developing chick retina:
Evidence for a role in migration of retinal ganglion cells. *Dev. Biol.*
**180**, 82-96.

Bassuk, J.A., Birkebak, T., Rothmier, J.D., Clark, J.M., **Bradshaw,
A**., Muchowski, P.J., Howe, C.C., Clark, J.I., and Sage, E.H. (1999)
Disruption of the *Sparc* locus in mice alters the differentiation of
lenticular epithelial cells and leads to cataract formation. *Exp. Eye
Res*. **68**, 321-331.

**Bradshaw, A.D**., Francki, A.F., Motamed, K., Howe, C. and Sage, E.H.
(1999) Primary mesenchymal cells isolated from SPARC-null mice exhibit
altered morphology and rates of proliferation. *Mol. Biol. Cell*,
**10**, 1569-1579.

Francki, A.F., **Bradshaw, A.D**., Bassuk, J., Vernon, R.B., Howe, C.
and Sage, E.H. (1999) SPARC regulates the expression of collagen type I
and transforming growth factor-β in mesangial cells. *J.Biol. Chem.*
**274**, 32145-32152.

Bassuk, J.A., Pichler, R., Rothmier, J.D., Pippen, J., Gordon, K., Meek,
R.L., **Bradshaw , A.D**., Lombardi, D., Strandjord, T.P., Reed, M.,
Sage, E.H., Couser, W.G., and Johnson, R. (2000) Induction of TGF-β1 by
the matricellular protein SPARC in a rat model of glomerulonephritis.
*Kid. Int*. **57**, 117-128.

**Bradshaw, A.D**., Bassuk, J., Francki, A., and Sage, E.H. (2000)
Expression and purification of recombinant human SPARC produced by
baculovirus. *Mol. Cell Biol. Res. Comm.* **3***,* 345-351.

**Bradshaw, A.D.** and Sage, E.H. (2001) SPARC, a matricellular protein
that functions in cellular differentiation and tissue response to
injury. *J. Clin. Invest.* **107**, 1049-1054*.*

**Bradshaw, A.D.,** Reed, M.J., Carbon, J.G., Pinney, E., Brekken, R.A.,
and Sage, E.H. (2001) Increased fibrovascular invasion of subcutaneous
polyvinyl alcohol sponges in SPARC-null mice. *Wound Repair Regen*.
**9**, 522-530.

**Bradshaw, A.D**., Reed, M.J., and Sage, E.H. (2002) SPARC-Null mice
exhibit accelerated cutaneous wound closure. *J. Histochem. Cytochem.*
**50**, 1-10.

Puolakkainen, P., **Bradshaw, A.D.,** Kyriakides, T.R., Reed, M.,
Brekken, R., Wight, T., Bornstein, P., Ratner, B., and Sage, E.H. (2003)
Mice that lack the matricellular protein SPARC exhibit a reduced foreign
body reaction to implanted materials. *Am. J. Pathol.* **162**, 627-35.

**Bradshaw, A.D.**, Graves, D.C., Motamed, K., and Sage, E.H. (2003)
SPARC-null mice exhibit increased adiposity without significant
differences in overall body weight. *Proc. Natl. Acad. Sci USA* **100**,
6045-6050.

Delaney, A.M., Kalajzic, I., **Bradshaw, A.D.**, Sage, E.H., and
Canalis, E. (2003) Osteonectin-null mutation compromises osteoblast
formation, maturation, and survival. *Endocrinol.* **144**, 2588-2596.

**Bradshaw, A.D.,** Puolakkainen, P., Dasgupta, J., Davidson, J.M.,
Wight, T.N., and Sage, E.H. (2003) SPARC-null mice display phenotypic
skin abnormalities characterized by reduced tensile strength and
decreased dermal collagen fibril diameter. *J. Invest. Dermatol.*
**120**, 949-55.

Brekken, R.A., Sullivan, M.M., Workman, G., **Bradshaw, A.D.,** Carbon,
J., Siadek, A., Murri, C., Framson, P.E., and Sage, E.H. (2004)
Expression and characterization of murine hevin (SC-1), a member of the
SPARC family of matricellular proteins. *J. Histochem. Cytochem.*
**52**, 735-48.

Sweetwyne, M.T., Brekken, R.A., Workman, G., **Bradshaw, A.D.,** Carbon,
J., Siadek, A.W., Murri, C., and Sage, E.H. (2004) Functional analysis
of the matricellular protein SPARC with novel monoclonal antibodies. *J.
Histochem. Cytochem.* **52**, 723-33.

Aycock, R., **Bradshaw, A.D.,** Sage, E.H., and Starcher, B. (2004)
Development of UV-Induced Squamous Cell Carcinomas is Suppressed in the
Absence of SPARC. *J. Invest. Dermatol.* **123**, 592-9.

Puolakkainen PA, **Bradshaw AD**, Brekken RA, Reed MJ, Kyriakides T,
Funk SE, Gooden MD, Vernon RB, Wight TN, Bornstein P, Sage EH. (2005)
SPARC-thrombospondin-2-double-null Mice Exhibit Enhanced Cutaneous Wound
Healing and Increased Fibrovascular Invasion of Subcutaneous Polyvinyl
Alcohol Sponges. *J Histochem Cytochem.* **53**, 571-81.

Reed, M.J., **Bradshaw, A.D.,** Shaw, M., Sadoun, E., Han, N., Ferara,
N., Funk, S., Puolakkainen, P., and Sage, E.H. (2005) Enhanced
Angiogenesis Characteristic of SPARC-Null Mice Disappears with Age. *J.
Cell. Physiol.* 204, 800-7.

Poobalarahi, F., Baicu, C., and **Bradshaw, A.D.** (2006) Cardiac
Myofibroblasts Differentiated in 3-D Culture Exhibit Distinct Changes in
Collagen I Production, Processing, and Matrix Deposition. *Am. J.
Physiol. Heart Circ. Res*. 291, H2924-32.

Rentz, T.J., Poobalarahi, F., Bornstein, P., Sage, E.H. and **Bradshaw,
A.D.** (2007) SPARC regulates processing of procollagen I and collagen
fibrillogenesis in 

dermal fibroblasts. *J. Biol. Chem*. **282**, 22062-71.

**Bradshaw, A.D.,** Baicu, C.F., Rentz, T.J., Derienzo, C., Boggs, J.,
Van Laer, A., Lacy, J., and Zile, M.R. (2009) Pressure-Overload Induced
Alterations in Myocardial Hypertrophy and Extracellular Collagen
Content: Role of SPARC-Dependent Post-Synthetic Collagen Processing.
*Circulation **In press***.

Li, J., Zhang, Y., Yamane, K., Boggs, J., Poobalarahi, F., Cooper, G.,
and **Bradshaw A.D**. (2009) Collagen Deposition in Response to
Hypertrophy Induced by Pressure-Overload in Felines. *In preparation.*

**Bradshaw, A.D.,** Baicu, C., Boggs, J., Zile, M.R., Schey K., Arthur,
J. (2009) Analysis of Early Changes in the Right Ventricular Proteome
Associated with Pressure Overload-Induced Cardiac Hypertrophy. *In
preparation*.

**Bradshaw, A.D.,** Baicu, C.F., Rentz, T.J., Derienzo, C., Van Laer,
A., Boggs, J., and Zile, M.R. (2009) SPARC regulates collagen deposition
and muscle stiffness in the aging myocardium. *In preparation*.

Zhang, Y., Rentz, T.J., Visconti, R. and **Bradshaw A.D.** (2009) The
absence of SPARC compromises structural integrity of the periodontal
ligament in mice. *In preparation*.

## Book Chapters

Clegg, D.O., Mullick, L.H., Wingerd, K.L., Lin, H., Atienza, J.W.,
**Bradshaw, A.D**., Gervin, D.B., and Cann, G.M. (2000) Adhesive events
in retinal development and function: the role of integrin receptors. In
[Results]{.underline} [and]{.underline} [Problems]{.underline}
[in]{.underline} [Cell]{.underline} [Differentiation]{.underline}, Vol.
**31**, [Vertebrate]{.underline} [Eye]{.underline}
[Development]{.underline}, E.Fini, Ed. Springer-Verlag, Berlin
Heidelberg, 141-156.

**Bradshaw, A.D**. and Sage, E.H. (2000) Regulation of cell behavior by
extracellular proteins: Matricellular proteins as modulators of cell
function. In [Principles]{.underline} [of]{.underline}
[Tissue]{.underline} [Engineering]{.underline}, Lanza, R., Langer, R.,
and Vacanti, J., Eds. Academic Press, San Diego, CA, 119-127.

**Bradshaw, A.D**. and Sage, E.H. (2000) Regulation of vascular
morphogenesis by extracellular matrix proteins. In [The]{.underline}
[New]{.underline} [Angiotherapy]{.underline}, T.-P. D. Fan, Ed., Humana
Press, Inc., Cambridge, 51-66.

Sage, E.H., **Bradshaw, A.D.,** and Brekken, R.A. (2003) SPARC, a
Matricellular Protein that Regulates Cell-Matrix Interaction:
Implications for Vascular and Connective Tissue Biology.
[In]{.underline} Extracellular Matrix and The Liver -- Approach to Gene
Therapy, Okazaki, I., Y. Ninomiya, S.L. Friedman, and K. Tanikawa, eds.,
Academic Press, Tokyo, 76-85.

Sage, E.H. and **Bradshaw, A.D**. (2007) Regulation of cell behavior by
extracellular proteins: Matricellular proteins as modulators of cell
function. In [Principles]{.underline} [of]{.underline}
[Tissue]{.underline} [Engineering]{.underline}, 3^rd^ Edition, Lanza,
R., Langer, R., and Vacanti, J., Eds. Academic Press, San Diego, CA,
119-127.

Brekken, R.A. and **Bradshaw, A.D**. (2009) The Function of SPARC in
Tumor Cell Biology: SPARC as a Modulator of Cell:ECM Interaction. in
*[Cell-Extracellular Matrix Interactions in Cancer]{.underline}*. Pozzi,
A and Zent R, Eds. Springer, New York, NY. *In press.*

## Abstracts

Clegg, D.O., Choi, E.S., Johnson, J.A., Snyder, J., Wayner, E.A.,
Carter, W.G., Gervin, D.B., **Bradshaw, A.D**., and Eckley, D.M. (1989)
Evidence for involvement of the integrin α3 subunit in process outgrowth
on laminin. Soc. Neurosci. Annual Meeting, Phoenix, AZ, #232.17.

**Bradshaw, A.D.,** McNagny, K.M., Gervin, D.B., Cann, G.C. and Clegg,
D.O. (1995) Integrin α2β1 mediates interactions between developing
embryonic retinal cells and collagen. ASCB Annual Meeting, San
Francisco, CA. #1355.

Cann, G.C., **Bradshaw A.D.,** and Clegg D.O. (1995) Integrin α4β1 and
VCAM-1 are expressed in the developing retina and mediate process
outgrowth. ASCB Annual Meeting, San Francisco, CA. #1356.

**Bradshaw, A.D.,** Francki, A, Motamed, K., Howe, C., and Sage, E.H.
(1998) Primary mesenchymal cells isolated from SPARC-null mice exhibit
altered morphology and proliferation rates relative to wild-type cells.
ASCB Annual Meeting, San Francisco, CA. #1757.

Francki, A., **Bradshaw, A.D.,** Bassuk, J.A., Carbon, J.G., Howe, C.,
and Sage, E.H. (1998) SPARC regulates collagen type I and TGF-β
expression in mouse mesangial cells. ASCB Annual Meeting, San Francisco,
CA. #964.

**Bradshaw, A.D**., Reed, M.J., and Sage, E.H. (2000) SPARC-Null Mice
Exhibit Accelerated Wound Healing and Increased Cellular Invasion in the
Sponge Model of Angiogenesis. Thrombospondins 2000, Madison, WI.

**Bradshaw, A.D.,** Reed, M.J., and Sage, E.H. (2000) SPARC-null Mice
Exhibit Accelerated Wound Healing, Altered Extracellular Matrix in the
Dermis, and Increased Cellular Invasion in a Sponge Model of
Angiogenesis. Biology and Pathology of the Extracellular Matrix, St.
Louis, MO.

**Bradshaw, A.D.,** Reed, M.J., Pinney, E., Carbon, J., and Sage, E.H.,
(2001)

SPARC-null Mice Exhibit Accelerated Wound Healing, Altered Extracellular
Matrix in the Dermis, and Increased Cellular Invasion in a Sponge Model
of Angiogenesis. Wound Healing Society, Albuquerque, NM.

**Bradshaw, A.D.,** Reed, M.J., Brekken, R.A., Pinney, E., Wight, T.N.,
and Sage, E.H. (2001) SPARC-null Mice Exhibit Accelerated Wound Healing,
Altered Dermal Extracellular Matrix, and Increased Cellular Invasion in
a Sponge Model of Angiogenesis. BECON Reparative Medicine, Bethesda, MD.

Puolakainnen, P., **Bradshaw, A.D**., Kyriakides, T., Lehman, A.,
Brekken R., Bornstein, P., and Sage, E.H. (2001) Reduced Foreign Body
Response to Implanted Biomaterials in SPARC-Null Mice. BECON Reparative
Medicine, Bethesda, MD.

**Bradshaw, A.D**., Puolakkainen, P., Dasgupta, J., Davidson, J.M.,
Wight, T.N., Sage, E.H. (2002) SPARC Influences the Structure and
Composition of the Dermal ECM. Gordon Research Conference, Basement
Membranes, Plymouth NH.

**Bradshaw,** **A.D.**, Puolakkainen, P., Dasgupta, J., Davidson, J.M.,
Wight, T.N., Sage, E.H. (2002) SPARC Influences the Structure and
Composition of the Dermal ECM.

ASCB Annual Meeting, San Francisco, CA.

Westin, K., Sage, E.H., **Bradshaw,** **A.D.** (2003) Decreased Collagen
Accumulation in SPARC-null Mice is Associated with Increased Adiposity.
Gordon Research Conference: Collagen, New London, NH.

Poobalarahi , F., Hills J., Sage, E.H., **Bradshaw, A.D.** (2005) SPARC
Influences Collagen I Fibril Maturation and Extracellular Matrix
Deposition. Gordon Research Conference: Collagen, New London, NH.

Rentz T., Poobalarahi, F., **Bradshaw, A.D**. (2006) SPARC Regulates
Procollagen I Processing and Cell Binding. American Society for Matrix
Biology Meeting, Nashville, TN.

Baicu, C.F., **Bradshaw, A.D.,** Aho, M.R., Van Laer, A.O., Boland, T.,
Zile, M.R. (2007) Rapid Prototyping of Cardiac Constructs using Isolated
Cardiomyocytes and Fibroblasts. South Carolina Bioengineering Summit,
Charleston, SC

Rentz, T.J., Zhang, Y., Bornstein, P., and **Bradshaw, A.D.** (2007)
SPARC-Null Mice that Express Procollagen α1(I) Lacking N-propeptides
Exhibit Abdominal Hernias. Gordon Research Conference: Collagen, New
London NH.

**Bradshaw, A.D.,** Baicu, C.F., Rentz, T.J., Derienzo, C., Van Laer,
A., Boggs, J., and Zile, M.R. (2007) Role of SPARC in Post-Synthetic
Collagen Processing in the Aging Myocardium. Heart Failure Society of
America, Washington D.C.

**Bradshaw, A.D.,** Baicu, C.F., Rentz, T.J., Derienzo, C., Boggs, J.,
Van Laer, A., Lacy, J., and Zile, M.R. (2007) Pressure-Overload Induced
Alterations in Myocardial Hypertrophy and Extracellular Collagen
Content: Role of SPARC-Dependent Post-Synthetic Collagen Processing.
Heart Failure Society of America, Washington D.C.

Grant, J.E., **Bradshaw, A.D.,** Schwacke, J.H., Baicu, C.F., Zile,
M.R., and Schey, K.L. (2008) Towards quantitation of a heart
glycoproteome using iTRAQ. 55th American Society for Mass Spectrometry
Conference; Denver, CO

Baicu, C.F., **Bradshaw, A.D.,** Boggs, J.M., Rentz, T.J., Van Laer,
A.O., Kindy, M.S., Zile, M.R. (2008) Effects of Inhibition of AGE-RAGE
Interaction in Pressure-Overload Hypertrophy by Treatment with sRAGE.
12^th^ Annual Heart Failure Society of America, Toronto, CA

Zhang, Y., Visconti, R., and **Bradshaw, A.D.** (2008) Aberrant Collagen
Fibril Morphology in Periodontal Ligament of SPARC-null mice. 2nd
Biennial NISBRE Symposium, Washington DC

Zhang, Y., Visconti, R., and **Bradshaw, A.D**. (2008) Aberrant Collagen
Fibril Morphology in Periodontal Ligament of SPARC-null mice.
International Association for Dental Research, Toronto, Canada

**Bradshaw, A.D**., Baicu, C.F., Rentz, T.J., Derienzo, C.C., Boggs,
J.M., Van Laer, A.O., Zile, M.R. (2008) SPARC Effects Collagen
Deposition in Myocardial Hypertrophy. American Society for Matrix
Biology, San Diego, CA

Zhang, Y., Rivera, L.B., Brekken, R.A., **Bradshaw, A.D.** (2008) SPARC
Influences Collagen Interaction with the Cell Surface. American Society
for Matrix Biology, San Diego, CA

**Bradshaw, A.D.,** Baicu, C.F., Schwake, J.H., Yamane, K., Rentz, T.J.,
Lacy, J.M., Gallien, T.N., Schey, K.L., Zile, M.R. (2008) Quantitative
Proteomic Analysis of Hypertrophied Rat Myocardium. American Society for
Matrix Biology, San Diego, CA

Pinney, E., Ziegler, F., Naughton, G., Bradshaw, A.D., Kellar, R. (2008)
Changes in ECM in High/Low/Normal Oxygen in 3D Cultures. American
Society for Matrix Biology, San Diego, CA

## Peer Review and Editorial Consultations

Journal of Molecular and Cellular Cardiology (2003-present)

Journal of Cell Science (2007-present)

Artheriosclerosis (2005)

Cardiovascular Research (2006-present)

American Journal of Physiology (2006-present)

Circulation (2007-present)

Matrix Biology (2008- present)

National Institute of Aging, N.I.H., Ad Hoc Reviewer (2007)

## National Institute of Arthritis and Musculoskeletal and Skin Diseases, N.I.H. Ad Hoc Reviewer (2009)

## Grant Awards

**Current**:

P20 2P20RR017696-06 Kirkwood, K. (P.I.)

NIH: South Carolina COBRE for Oral Health

7/07-7/10

Project 6: Bradshaw (P.I.)

The function of SPARC in the regulation of collagen deposition in the
periodontal ligament.

Studies designed to characterize SPARC activity in the periodontal
ligament in vivo and in vitro.

1 R01 CA118240-01A2 Brekken, R.A. (P.I., UTSW, Dallas)

9/07-7/11

NIH/NCI

Matricellular proteins as regulators of tumor progression

Studies designed to elucidate the function of SPARC in ECM formation
associated with tumor angiogenesis and metastatsis.

VA Merit Bradshaw, A. (P.I.)

Department of Veterans Affairs

10/1/08-9/30/11

Post-synthetic Collagen Processing in Age-dependent LV Remodeling

Studies designed to elucidate the role of post-synthetic procollagen
processing in aged myocardium.

**Pending:**

5PO1 HL048788-16-20 Cooper, G (P.I.)

NIH/NHLBI

Load-Induced Cardiac Hypertrophy in the Adult Mammal

Project 6: Zile/Bradshaw (co-PIs)

Procollagen processing in load-induced remodeling.

Studies proposed to investigate the mechanism of the post-synthetic
procollagen processing in cardiac hypertrophy.

**Completed:**

VA Career Development Award Bradshaw (Mentee) Cooper (Mentor)

4/06-4/08

Department of Veterans Affairs

Salary support provided to develop a research program in cardiac
interstitium.

1 R21 DK066486-01 Bradshaw (Co-PI) 9/03-9/05

NIH/NIDDK

Control of Adipocyte Hypertrophy by Extracellular Matrix

Studies proposed to investigate developmental and obesity-dependent
changes in the ECM of fat tissue and primary adipocytes.

1 KO-1 AR02220-01A Bradshaw (PI) 7/01-6/05

NIH/NIAMS

SPARC Modulates ECM Dynamics in Skin

Studies proposed to investigate the function of SPARC in matrix
remodeling events in the skin such as angiogenesis, wound healing, and
foreign body response.