<table>
<colgroup>
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<col style="width: 18%" />
<col style="width: 7%" />
<col style="width: 3%" />
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<col style="width: 0%" />
<col style="width: 7%" />
<col style="width: 3%" />
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<col style="width: 8%" />
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<col style="width: 1%" />
<col style="width: 8%" />
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<col style="width: 2%" />
<col style="width: 12%" />
</colgroup>
<tbody>
<tr class="odd">
<td colspan="6"><p>SAIC-Frederick, Inc.</p>
<p>A subsidiary of Science Applications International
Corporation</p></td>
<td colspan="5">1. Subcontract No.</td>
<td colspan="4"><p>2. Solicitation No.</p>
<p>S09-094</p></td>
<td colspan="3"><p>3. Date Issued</p>
<p>12/19/08</p></td>
<td colspan="5">Page 1 of 56</td>
</tr>
<tr class="even">
<td colspan="4">4. Maryland Sales and Use Tax Direct Pay Permit No.
3</td>
<td colspan="14"><p>5.  Sealed Bid (IFB) Solicitation</p>
<p> Negotiated (RFP) Solicitation</p></td>
<td colspan="5"><p>6. Requisition No.</p>
<p>1X5502</p></td>
</tr>
<tr class="odd">
<td colspan="11" rowspan="3"><p>7. Issued By: Address Offer To:</p>
<p>SAIC-Frederick, Inc. SAIC-Frederick, Inc.</p>
<p>Research Contracts Dept Research Contracts Dept.</p>
<p>1050 Boyles Street 1050 Boyles Street</p>
<p>Frederick, Md. 21702 Frederick, MD 21702</p></td>
<td colspan="12">8. Delivery Date: n/a</td>
</tr>
<tr class="even">
<td colspan="12">9. Place of Delivery: n/a</td>
</tr>
<tr class="odd">
<td colspan="12">10. FOB: Destination</td>
</tr>
<tr class="even">
<td colspan="23"><strong>SOLICITATION</strong></td>
</tr>
<tr class="odd">
<td colspan="23"><mark>11. To be timely, offers must be received as
requested in Section L: Instructions, Conditions, and Notices to
Offerors NO LATER THAN4:00 PM (EST) ON FEBRUARY 5, 2009</mark>.</td>
</tr>
<tr class="even">
<td colspan="2">12. FOR INFORMATION CALL:</td>
<td colspan="10">Name: Jennifer Thomas</td>
<td colspan="11">Telephone No. 301-228-4004</td>
</tr>
<tr class="odd">
<td colspan="23"><p>OFFER/SUBCONTRACT CONSISTS OF:</p>
<p><strong>Part 1 – The Schedule</strong> <strong>Part 2 – Contract
Clauses</strong></p>
<p>A. Solicitation/Contract Form I. Contract Clauses</p>
<p>B. Supplies or Services and Prices/Costs <strong>Part 3 – List of
Documents, Exhibits and Other Attachments</strong></p>
<p>C. RFP Statement of Objectives J. List of Attachments</p>
<p>D. Packaging and Marking <strong>Part 4 – Representations and
Instructions</strong></p>
<p>E. Inspection and Acceptance K. Representations, Certifications and
Other Statements</p>
<p>F. Deliveries or Performance L. Instructions, Conditions, and Notices
to Offerors</p>
<p>G. Contract Administration Data M. Evaluation Factors for Award</p>
<p>H. Special Contract Requirements</p></td>
</tr>
<tr class="even">
<td colspan="23"><strong>SCHEDULE</strong></td>
</tr>
<tr class="odd">
<td><strong>ITEM NO.</strong></td>
<td colspan="8"><strong>SUPPLIES/SERVICES</strong></td>
<td colspan="4"><strong>QTY.</strong></td>
<td colspan="4"><strong>UNIT</strong></td>
<td colspan="5"><strong>UNIT PRICE</strong></td>
<td><strong>AMOUNT</strong></td>
</tr>
<tr class="even">
<td></td>
<td colspan="8">See Attachment 5 and, upon award, Attachment 6</td>
<td colspan="4"></td>
<td colspan="4"></td>
<td colspan="5"></td>
<td></td>
</tr>
<tr class="odd">
<td colspan="23">13. If this offer is accepted within <u>90</u> calendar
days from the date for receipt of offers specified above, the offeror
shall be required to furnish any or all items or services in accordance
with the terms of the offer.</td>
</tr>
<tr class="even">
<td colspan="5"><p>14. DISCOUNT FOR PROMPT PAYMENT</p>
<p><em>(In connection with any discount for prompt payment, time shall
be computed from the date of invoice acceptance.)</em></p></td>
<td colspan="5"><p>10 CALENDAR DAYS</p>
<p>%</p></td>
<td colspan="4"><p>20 CALENDAR DAYS</p>
<p>%</p></td>
<td colspan="6"><p>30 CALENDAR DAYS</p>
<p>%</p></td>
<td colspan="3"><p>__ CALENDAR DAYS</p>
<p>%</p></td>
</tr>
<tr class="odd">
<td colspan="5" rowspan="3"><p>15. ACKNOWLEDGMENT OF AMENDMENTS</p>
<p><em>(The offeror acknowledges receipt of amendments to the
solicitation for offerors and related documents numbered and
dated)</em></p></td>
<td colspan="5">AMENDMENT NO.</td>
<td colspan="4">DATE</td>
<td colspan="6">AMENDMENT NO.</td>
<td colspan="3">DATE</td>
</tr>
<tr class="even">
<td colspan="5"></td>
<td colspan="4"></td>
<td colspan="6"></td>
<td colspan="3"></td>
</tr>
<tr class="odd">
<td colspan="5"></td>
<td colspan="4"></td>
<td colspan="6"></td>
<td colspan="3"></td>
</tr>
<tr class="even">
<td colspan="8">16. Name and Address of Offeror <strong>(include
Offeror’s DUNS Number):</strong></td>
<td colspan="15">17. Name and Title of Person Authorized to Sign
Offer:</td>
</tr>
<tr class="odd">
<td colspan="8">18. Submission of a signed offer constitutes an
understanding and unqualified acceptance of all terms, conditions,
obligations and statements or certifications made herein (or by
reference) or as attached hereto.</td>
<td colspan="11">19. Signature</td>
<td colspan="4">20. Date</td>
</tr>
<tr class="even">
<td colspan="23"><strong>AWARD</strong></td>
</tr>
<tr class="odd">
<td colspan="3">21. Accepted As To Items Numbered:</td>
<td colspan="13">22. Amount:</td>
<td colspan="7">23. Accounting Data: 200921769207</td>
</tr>
<tr class="even">
<td colspan="7">24. Name/Title of Person Authorized to Sign-SAIC</td>
<td colspan="14">25. Signature of Person Authorized to Sign-SAIC</td>
<td colspan="2">26. Award Date</td>
</tr>
</tbody>
</table>

PART 1---THE SCHEDULE

## SECTION B---SUPPLIES OR SERVICES AND PRICES/COSTS {#section-bsupplies-or-services-and-pricescosts .Header-2}

ARTICLE B.1. BRIEF DESCRIPTION OF SUPPLIES OR SERVICES

Independently, and not as an agent of the Government or SAIC-Frederick,
Inc. (SAIC-F), the Subcontractor shall furnish services, qualified
personnel, materials, equipment, and facilities not otherwise provided
under the terms of this Subcontract, as needed, to perform *in silico*,
hypothesis-driven research using data analysis, aggregation and mining
focused on discovery using caBIG and other publicly available
cancer-related data sources.

ARTICLE B.2. TYPE OF CONTRACT

This is a Firm Fixed Price contract as described in FAR Part 16.202-1. A
firm-fixed price contract provides for a price that is not subject to
any adjustment based on the subcontractor's cost experience.

ARTICLE B.3. PRICES/COSTS

The total Firm Fixed Price for this effort is \$\_\_\_\_\_\_\_\_\_\_\_\_
(Upon award, see Attachment 4 - Price Schedule).

  ------------------ ---------------------------------- ----------- ------------
  **Subcontract      **Period Covered**                 **Price**   **Status**
  Period**                                                          

  **Base Period**    **12-months from Date of Award**               

  Option Period One  12-months following Base Period                
  (1)                Expiration                                     

  Option Period Two  12-months following Option Period              
  (2)                One Expiration                                 
  ------------------ ---------------------------------- ----------- ------------

ARTICLE B.4. ADVANCE UNDERSTANDINGS

[Items Unallowable Unless Otherwise Provided]{.underline}

Notwithstanding the clause, ALLOWABLE COST AND PAYMENT, incorporated in
this subcontract, unless authorized in writing by the Contracting
Officer, the costs of the following items or activities shall be
unallowable as direct costs:

(1) Acquisition, by purchase or lease, of any interest in real property;

(2) Special re-arrangement or alteration of facilities;

(3) Purchase or lease of any item of general purpose office furniture or
    office equipment regardless of dollar value. (General purpose
    equipment is defined as any items of personal property, which are
    usable for purposes other than research, such as office equipment
    and furnishings, pocket calculators, etc.); unless otherwise
    provided for in Attachment 4;

(4) Travel to attend general scientific meetings, whether at domestic or
    foreign locations; unless otherwise provided for in Attachment 4;

(5) Consultant expenses; and

(6) Subcontracts; unless otherwise provided for in Attachment 4.

[Items to be Furnished to the Subcontractor]{.underline}

None

[Travel Costs]{.underline}

> Travel including lodging, other subsistence, and incidental expenses
> shall be allowable only to the extent that they do not exceed the
> amounts allowed for Federal employees and as provided in Attachment 4.
> The Subcontractor, therefore, shall invoice and be reimbursable for
> all travel costs in accordance with FAR Subpart 31.205-46. All
> required travel not identified in the approved budget must be
> preapproved by the contracting officer before costs may be incurred.

[Confidentiality]{.underline}

The subcontractor shall address the potential sensitivity of the
information collected, information security issues, local Institutional
Review Board (IRB) requirements, and the Health Insurance Portability
and Accountability Act (HIPAA) of 1996 in its performance of subcontract
requirements.

Final regulations issued by the Department of Health and Human Services
(DHHS) provide privacy and security standards that must be observed in
the handling of patient data resulting from biomedical research. HIPAA
privacy standards will be used to establish safeguards and restrictions
for the use and disclosure of research records. HIPAA security standards
will be used to help cancer centers implement administrative, physical,
and technical safeguards to protect electronic health information.
Improper use or disclosure of sensitive information under the rules may
be subject to criminal or civil sanctions prescribed in HIPAA.

##  {#section .Header-2}

## SECTION C---DESCRIPTION/SPECIFICATIONS/STATEMENT OF OBJECTIVES {#section-cdescriptionspecificationsstatement-of-objectives .Header-2}

\[See Attachment 5 for RFP Statement of Objectives and, upon Award,
Attachment 6 for Subcontract Statement of Work\]

## SECTION D---PACKAGING AND MARKING {#section-dpackaging-and-marking .Header-2}

ARTICLE D.1. PACKAGING AND SHIPPING

Any deliverables required under this subcontract, shall be packaged,
marked, and shipped in accordance with Government specifications. The
Subcontractor shall guarantee that all required materials be delivered
in immediate usable and acceptable condition.

##  {#section-1 .Header-2}

##  {#section-2 .Header-2}

## SECTION E---INSPECTION AND ACCEPTANCE {#section-einspection-and-acceptance .Header-2}

ARTICLE E.1. INSPECTION AND ACCEPTANCE

A.  The SAIC-F Contracting Officer or a duly authorized representative
    will perform an evaluation of the overall services provided and
    deliverables submitted. When deliverables meet the acceptance
    criteria as outlined below and as specifically defined, upon award,
    in Attachment 6 Deliverable Acceptance Criteria, the SAIC-F
    Contracting Officer will issue the Subcontractor a written
    acceptance that acknowledges both receipt and overall acceptance of
    the deliverable. Irrespective of payment status for subject
    deliverable, Subcontractor should not assume acceptance has been
    made without formal notification from the SAIC-F Contracting
    Officer.

B.  Inspection and acceptance will be performed at the National Cancer
    Institute - Frederick (NCI-Frederick), Frederick***,*** Maryland.

C.  General Acceptance Criteria

D.  In addition to specific acceptance criteria referenced above,
    general quality measures, as set forth below, will be applied to
    each deliverable received from the Subcontractor under this
    statement of work.

-   Accuracy -- Deliverables shall be accurate in presentation,
    technical content, and adherence to accepted elements of style.

-   Clarity -- Deliverables shall be clear and concise. Any/All diagrams
    shall be easy to understand and be relevant to the supporting
    narrative.

-   Consistency to Requirements -- All Deliverables must satisfy the
    requirements of this statement of work.

-   Timeliness -- Deliverables shall be submitted on or before the due
    date specified in this statement of work or the PMP, or submitted in
    accordance with a later scheduled date determined by the SAIC-F
    COTR.

## SECTION F---DELIVERIES OR PERFORMANCE {#section-fdeliveries-or-performance .Header-2}

ARTICLE F.1. PERIOD OF PERFORMANCE

A.  Unless SAIC-Frederick, Inc. exercises its option set forth below,
    the Base Period of Performance of this Subcontract shall be 12
    months from the date of award with two (2) 12-month Option Periods:

B.  SAIC-Frederick, Inc. reserves the right to award such option periods
    unilaterally.

C.  Option to Extend the Term of the Subcontract.

> SAIC-Frederick, Inc. may extend the term of this Subcontract by
> written notice to the Subcontractor within 60 calendar days of the
> Subcontracts end date; provided that SAIC-Frederick, Inc. gives the
> Subcontractor a preliminary written notice of its intent to extend at
> least sixty (60 calendar days) before the Subcontract expires. The
> preliminary notice does not commit SAIC-Frederick, Inc, to an
> extension. If SAIC-Frederick, Inc. exercises this option, the extended
> Subcontract shall be considered to include this option clause.
>
> If SAIC-Frederick, Inc. exercises its option pursuant to this option
> clause, the period of performance will be increased as listed below:

  ------------------ --------------------------------------- ---------------
  **Subcontract      **Period Covered**                      **Status**
  Period**                                                   

  **Base Period**    **12-months from Date of Award**        **Exercised**

  Option Period One  12-months following Base Period         Not Exercised
  (1)                Expiration                              

  Option Period Two  12-months following Option Period One   Not Exercised
  (2)                Expiration                              
  ------------------ --------------------------------------- ---------------

ARTICLE F.2. PLACE OF PERFORMANCE

The majority of the work will be performed at the ISRCE facilities.

ARTICLE F.3. DELIVERIES

A.  Satisfactory performance of the final subcontract shall be deemed to
    occur upon written acceptance by the SAIC-Frederick Contracting
    Officer.

B.  Copies of all reports identified herein and attached shall be
    submitted to the following:

+-----------------------------------------------------------------------+
| Greg Korzeniewski                                                     |
+-----------------------------------------------------------------------+
| SAIC-Frederick, Inc.                                                  |
+-----------------------------------------------------------------------+
| Telephone: 301-402-9794                                               |
+-----------------------------------------------------------------------+
| E-mail: <gkorzeni@mail.nih.gov>                                       |
+-----------------------------------------------------------------------+
| []{.mark}                                                             |
+-----------------------------------------------------------------------+
| George Komatsoulis                                                    |
+-----------------------------------------------------------------------+
| NCI-CBIIT                                                             |
+-----------------------------------------------------------------------+
| Telephone: 301-451-2881                                               |
|                                                                       |
| E-mail: <komatsog@mail.nih.gov>                                       |
+-----------------------------------------------------------------------+
| []{.mark}                                                             |
+-----------------------------------------------------------------------+
| Jennifer Thomas                                                       |
+-----------------------------------------------------------------------+
| SAIC-Frederick, Inc.                                                  |
+-----------------------------------------------------------------------+
| Telephone: 301-228-4004                                               |
+-----------------------------------------------------------------------+
| E-mail: <thomasjennifer@mail.nih.gov>                                 |
+-----------------------------------------------------------------------+

ARTICLE F.3. STOP WORK ORDERS

This subcontract incorporates FAR Clause 52.242-15 Stop Work Order by
reference, with the same force and effect as if it were given in full
text. The full text of the clause may be accessed electronically at this
address: <http://www.arnet.gov/far/>.

## SECTION G---SUBCONTRACT ADMINISTRATION DATA {#section-gsubcontract-administration-data .Header-2}

ARTICLE G.1. SUBCONTRACT REPRESENTATIVES

A. **[Contracting Officer]{.underline}**. The following individual is
designated as the SAIC-Frederick Contracting Officer:

> Shannon Jackson
>
> SAIC-Frederick, Inc.
>
> P.O. Box B
>
> Frederick, MD 21702-1201
>
> Phone: 301-228-4022; Fax: 301-228-4037
>
> E-mail: <jacksonshannon@mail.nih.gov>
>
> Only the Contracting Officer has authority to: (1) direct or negotiate
> any changes to the Statement of Work; (2) modify or extend the period
> of performance; (3) change the delivery schedule; (4) authorize
> reimbursement to the Subcontractor of any costs incurred during the
> performance of this subcontract; or (5) otherwise change any terms and
> conditions of this subcontract. All changes to the Statement of Work
> will be accomplished by bilateral modification to the subcontract.
>
> ***Only the Contracting Officer as named above shall have the
> authority to prescribe changes to this subcontract or provide
> direction for which the Subcontractor will seek reimbursement. Any
> costs incurred by the Subcontractor not delineated herein or without
> the prior written approval of the Contracting Officer are incurred at
> the Subcontractor's significant risk of non-payment.***

B. **[Contracting Officer's Technical Representative
(COTR)]{.underline}.** The following individual is designated as the
SAIC-Frederick Contracting Officer's Technical Representative (COTR and
is authorized to provide technical guidance and otherwise represent
SAIC-Frederick as stated herein:

> Dr. Greg Korzeniewski
>
> SAIC-Frederick, Inc.
>
> 8424 Helgerman Court
>
> Gaithersburg, MD 20877
>
> Phone: 301-402-9794
>
> E-mail: <gkorzeni@mail.nih.gov>
>
> The Contracting Officer's Technical Representative/Technical Project
> Manager is responsible for: (1) monitoring the Subcontractor's
> technical progress, including the surveillance and assessment of
> performance and recommending to the Contracting Officer changes in
> requirements; (2) interpreting the Statement of Work and any other
> technical performance requirements; (3) performing technical
> evaluation as required; (4) performing technical inspections and
> acceptances required by this subcontract; and (5) assisting in the
> resolution of technical problems encountered during performance
>
> ***Neither the COTR nor any person or entity other than the
> Contracting Officer possess any authority, implied or apparent, to
> provide direction that may cause or influence the Subcontractor to
> incur additional costs for which reimbursement may be sought. Any
> costs incurred by the Subcontractor not delineated herein or without
> the prior written approval of the Contracting Officer are incurred at
> the Subcontractor's significant risk of non-payment.***

C. **[Subcontracts Specialist]{.underline}**. The following individual
has been designated as the SAIC-Frederick Subcontracts Specialist for
purposes of administering, processing, and handling contractual
documentation:

Jennifer Thomas

SAIC-Frederick, Inc.

> P.O. Box B
>
> Frederick, Maryland 21702-1201
>
> Phone: 301-228-4004
>
> Fax: 301-228-4037
>
> E-mail: <thomasjennifer@mail.nih.gov>

D. **[NCI Project Officer]{.underline}**. The following individual is
designated as the Project Officer and is authorized to provide technical
guidance:

George Komatsoulis

National Cancer Institute Center for Bioinformatics

> ***Neither the NCI Project Officer nor any person or entity other than
> the Contracting Officer possess any authority, implied or apparent, to
> provide direction that may cause or influence the Subcontractor to
> incur additional costs for which reimbursement may be sought. Any
> costs incurred by the Subcontractor not delineated herein or without
> the prior written approval of the Contracting Officer are incurred at
> the Subcontractor's significant risk of non-payment.***

E. **[Subcontractor Authorized Representative(s)]{.underline}**. The
following individual(s) is the designated representative of the Company
/ Institution:

TO BE COMPLETED BY OFFEROR

  -----------------------------------------------------------------------

  PRINT NAME

  TITLE

  ORGANIZATION

  ADDRESS

  ADDRESS

  PHONE NUMBER

  FAX NUMBER

  E-MAIL ADDRESS
  -----------------------------------------------------------------------

F. **[Subcontractor Authorized Invoice Administrator]{.underline}**. The
following individual(s) is responsible for preparation and submittal of
invoice(s):

**TO BE COMPLETED BY OFFEROR**

  -----------------------------------------------------------------------

  PRINT NAME

  TITLE

  ORGANIZATION

  ADDRESS

  ADDRESS

  PHONE NUMBER

  FAX NUMBER

  E-MAIL ADDRESS
  -----------------------------------------------------------------------

ARTICLE G.2. KEY PERSONNEL

Pursuant to the Key Personnel clause incorporated in this subcontract,
the following individual(s) are considered to be essential to the work
being performed hereunder and shall not be re-assigned or removed
without the concurrence of the Contracting Officer:

  --------------------------------- -- -----------------------------------
  [NAME]{.underline}                   [TITLE]{.underline}

                                       

                                       

                                       
  --------------------------------- -- -----------------------------------

ARTICLE G.3. INVOICE SUBMISSION

A. Payment terms begin after acceptance of proper invoice (see
Attachment 2 -- SAIC-Frederick Invoice Instructions) and shall be
submitted 30-days following the submittal of associated deliverable as
prescribed at ARTICLE B.3. PRICES/COSTS. Invoices are to be submitted in
U.S. Dollars.

Invoices may be submitted in one of two ways:

> \(1\) An original and one (1) copy may be mailed to the following
> designated payment office:

ATTN: Ms. Leasa Mercer

NCI-Frederick Cancer Research & Development Center

SAIC-Frederick, Inc.

P. O. Box B

Frederick, Maryland 21702-1201

> OR
>
> \(2\) Invoices may be submitted electronically to
> <apinvoices@mail.nih.gov>. All e-mail submissions must include the
> subcontractor name, subcontract number, and invoice number in the
> subject line of the e-mail.

B. Inquiries regarding payment of invoices shall be directed to the
attention of Jennifer Thomas at 301-228-4004.

> C. To expedite payment of invoices, it is essential that the
> Subcontractor provide sufficient data to support costs invoiced.

D. Payment shall be considered made on the date on which a check for
such payment is dated.

ARTICLE G.4. GOVERNMENT PROPERTY

All purchases of equipment regardless of value must be approved in
advance of purchase and reported, with receipts attached, on the
coinciding invoice. It is required that a Report of Capitalized
Non-Expendable Equipment be completed for all equipment purchases and
also submitted with coinciding invoice (see Attachment 4). All equipment
purchased for work in support of this subcontract that is reimbursed
under the subcontract shall remain the property of the U.S. Federal
Government unless further determination is made through the SAIC-F
Contracting Officer.

##  {#section-3 .Header-2}

##  {#section-4 .Header-2}

## SECTION H---SPECIAL CONTRACT REQUIREMENTS {#section-hspecial-contract-requirements .Header-2}

ARTICLE H.1. PUBLICATION

When publishing, or submitting for publication, in scientific,
peer-reviewed or other scholarly publications, the Subcontractor shall
acknowledge the support of the National Institutes of Health whenever
publicizing the work under this contract in any media by including an
acknowledgment substantially as follows:

> "This project has been funded in whole or in part with Federal funds
> from the National Cancer Institute, National Institutes of Health,
> under Contract No. HHSN261200800001E. The content of this publication
> does not necessarily reflect the views or policies of the Department
> of Health and Human Services, nor does mention of trade names,
> commercial products, or organizations imply endorsement by the U.S.
> Government."

For Abstracts: (due to space limitations) "Funded by NCI Contract No.
HHSN261200800001E"

ARTICLE H.2. PRESS RELEASES AND PUBLICITY

No press releases or publicity (hereinafter 'publicity') pertaining to
this subcontract including, but not limited to, press releases, public
announcements, advertising material and other documents describing
projects or programs funded in whole or in part with Federal money
regardless of media, shall be issued by Subcontractor without the prior
review and written consent of the SAIC-F Contracting Officer. When
authorized by SAIC-F, the publicity issued by the Subcontractor shall
clearly state:

> 1\. the percentage of the total cost of the program or project which
> will be financed with Federal money.
>
> 2\. the dollar amount of Federal funds for the project or program.
>
> 3\. the percentage and dollar amount of the total cost of the project
> or program that will be financed by nongovernmental sources in
> accordance with Public Law 109-149, Title V, Section 506.
>
> 4\. an acknowledgement substantially stated as follows:
>
> "This project has been funded in whole or in part with Federal funds
> from the National Cancer Institute, National Institutes of Health,
> under Contract No. HHSN261200800001E. The content of this publication
> does not necessarily reflect the views or policies of the Department
> of Health and Human Services, nor does mention of trade names,
> commercial products, or organizations imply endorsement by the U.S.
> Government."

ARTICLE H.3. SALARY RATE LIMITATION LEGISLATION PROVISIONS

A. Pursuant to Public Law, no NIH Fiscal Year funds may be used to pay
the direct salary of an individual through this contract at a rate in
excess of the applicable amount shown for the fiscal year covered.
Direct salary is exclusive of overhead, fringe benefits and general and
administrative expenses.

B. The per year salary rate limit also applies to individuals proposed
under subcontracts. If this is a multiple year contract, it may be
subject to unilateral modifications by the Government if an individual's
salary rate exceeds any salary rate ceiling established in future DHHS
appropriation acts (see link below for current Executive Salary Pay
Rates).

*\*Effective January 2008, this amount is \$191,300 and will remain at
this level until such time as the Executive Level I is increased. See
the web site listed below for FY-2008 Executive Level I rates of pay.
FYXX Executive Level Salaries:
[[http://www.opm.gov/oca/PAYRATES/index.htm]{.underline}](http://www.opm.gov/oca/PAYRATES/index.htm)*

ARTICLE H.4. REPORTING MATTERS INVOLVING FRAUD, WASTE AND ABUSE

Anyone who becomes aware of the existence of fraud, waste and abuse in
NIH funded programs is encouraged to report such matters to the HHS
Inspector General's Office in writing or on the Inspector General's
Hotline. The toll free number is 1-800-HHS-TIPS (1-800-447-8477). All
telephone calls will be handled confidentially. The e-mail address is
<Htips@os.dhhs.gov> and the mailing address is:

Office of Inspector General

Department of Health and Human Services

TIPS HOTLINE

P.O. Box 23489

Washington, D.C. 20026

Information regarding procedural matters is contained in the NIH Manual
Chapter 1754, which is available on
<http://www1.od.nih.gov/oma/manualchapters/management/1754/>.

ARTICLE H.5. ORGANIZATIONAL CONFLICT OF INTEREST

During the performance of this contract, the Subcontractor is prohibited
from engaging in similar work or services adverse to the interests of
SAIC-Frederick, Inc./NCI. The Subcontractor also certifies that no
services rendered under any agreement during the term of this contract
will be adverse to the interest of SAIC- Frederick, Inc./NCI. The
Subcontractor also certifies that no financial, contractual,
organizational, or other interest exists relating to the work under this
agreement that would constitute an Organizational Conflict of Interest
or otherwise cause the Subcontractor to be unable or potentially unable
to render impartial assistance or advice, impair objectivity in
performing the work, or create an unfair competitive advantage for any
entity wherein the Subcontractor has an interest. The Federal statutes
and regulations concerning conflict of interest carry criminal penalties
for violation. The Subcontractor is personally responsible for
identifying any such conflict of interest, or any relationship or
actions that might give the appearance that a conflict of interest
exists or could reasonably be viewed as affecting the Subcontractor's
objectivity in performing the work under this agreement. By signature
the Subcontractor certifies the understanding of the above and that no
Organizational Conflict of Interest exists that would affect this
Contract. The Subcontractor also indemnifies or otherwise holds harmless
SAIC-Frederick, Inc./NCI should an Organizational Conflict of Interest
become apparent (not previously disclosed) during the life of this
contract.

ARTICLE H.6. PROHIBITION ON SUBCONTRACTOR INVOLVEMENT WITH TERRORIST
ACTIVITIES

The Subcontractor acknowledges that U.S. Executive Orders and Laws,
including but not limited to E.O. 13224 and Public Law, prohibit
transactions with, and the provision of resources and support to
individuals and organizations associated with terrorism. It is the legal
responsibility of the Subcontractor to ensure compliance with these
Executive Orders and Laws. This clause must be included in all
subcontracts issued under this contract.

ARTICLE H.7. INSURANCE REQUIREMENTS AND CERTIFICATES

The Subcontractor must provide Certificates of Insurance, proving:

a.  Commercial General Liability coverage

b.  Errors & Omissions coverage

c.  Professional Liability coverage

d.  Property Damage coverage

e.  Automobile Liability coverage

f.  All Risk coverage

g.  Worker's Compensation coverage

h.  Foreign Workers' Compensation coverage (including Defense Base Act
    coverage)

The Certificate of Insurance shall certify that the Subcontractor is
insured for the period of performance of this Subcontract. Further, the
Certificate of Insurance shall name SAIC-Frederick, Inc. as
"Additionally Named Insured". The contract number and name of the
project shall be included in the block naming SAIC-Frederick, Inc. as
Additional Named Insured.

If at any time the period of performance of this Subcontract the
insurance coverage lapses or is cancelled, the Subcontractor will
immediately notify SAIC-Frederick, Inc.

ARTICLE H.8. ADDITIONAL INTELLECTUAL PROPERTY REQUIREMENTS FOR ALL
DELIVERABLES

A.  DEFINITIONS

    a.  "caBIG Community" -- all participants in caBIG, including,
        without limitation, all Subcontractors of SAIC-F for caBIG,
        other contractors of the NCI and their Subcontractors, and
        persons participating on a volunteer basis in caBIG

    b.  "caBIG Community Website" -- the website
        ([https://cabig.nci.nih.gov](https://cabig.nci.nih.gov/)) /for
        caBIG™ Participants and others needing specific information
        about caBIG activities and products

    c.  "Model caBIG Software License" -- in its current form and posted
        on the caBIG Community Website, which may be accessed at the URL
        below, and as may be updated from time to time, the current
        version of which will always be the relevant document.

> <https://cabig.nci.nih.gov/working_groups/DSIC_SLWG/Documents/caBIG_Model_Open_Source_Software_License_v2_20080107.doc>

d.  "caBIG Participants" -- individual members of the caBIG Community

e.  "Deliverables" - all items first produced, developed, delivered or
    used in connection with development or adoption activities under
    this Subcontract, including, but not limited to, datasets, data
    files, software, (including application programming interfaces
    (APIs) and middleware), source code, object code, documentation,
    reports and other data (including Proprietary Software and
    Proprietary Technical Data for which separate approval has not been
    obtained pursuant to the requirements below).

f.  "Proprietary Software" -- Subcontractor or third party proprietary
    software applications that are not developed under this Subcontract

g.  "Proprietary Technical Data" \-- proprietary third party technical
    data or technical data proprietary to Subcontractor

h.  "Software Deliverables" -- collectively, caBIG Software and caBIG
    Software Modifications

i.  "caBIG Software" -- all source code, object code and related
    documentation that is funded, developed or delivered under this
    Subcontract

j.  "Technical Data Deliverables" -- all data except for Software
    Deliverables that are produced, developed, delivered or utilized in
    connection with development, testing, adoption or other activities
    performed under this Subcontract.

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B.  RIGHTS IN DATA

> It is specifically understood that an important Government purpose for
> the work to be performed under the Subcontract is world-wide, free
> distribution of all Deliverables under the rights granted pursuant to
> the Subcontract. The Subcontractor is hereby given Contracting
> Officer's advanced approval (to the extent possible), as required in
> FAR 52.227-14 Rights in Data, to assert copyright in Software
> Deliverables first produced in the performance of the Subcontract,
> provided, however, that upon the request of the Contracting Officer,
> Subcontractor agrees to assign copyright to the Government when the
> assignment of such copyright is necessary in order for the Government
> to protect its rights (by way of example but not limitation, in the
> event a third party were to allege copyright infringement the
> Government would want copyright ownership in order to have standing).
> Subcontractor grants to the Government, SAIC-F, the caBIG Community,
> and the public, "unlimited rights" in all Deliverables as defined in
> FAR 52.227-14, Rights in Data -- General. "Unlimited rights" means the
> rights of the Government to use, disclose, reproduce, prepare
> derivative works, distribute copies to the public, and perform
> publicly and display publicly, in any manner and for any purpose, and
> to have or permit others to do so.
>
> In addition to FAR 52.227-14, Rights in Data -- General and the
> Government purpose noted above, and notwithstanding anything to the
> contrary in the Subcontract, Subcontractor also agrees to grant to the
> Government, SAIC-F, the caBIG Community, and the public a
> nonexclusive, worldwide, perpetual, fully paid up, no-charge,
> irrevocable, transferable and royalty-free right and license in its
> rights in all Deliverables, including any copyright or patent rights
> therein, to: (a) use, install, disclose, access, operate, execute,
> reproduce, copy, modify, translate, market, publicly display, publicly
> perform, and prepare derivative works of Deliverables in any manner
> and for any purpose, and to have or permit others to do so; (b) make,
> have made, use, practice, sell, offer for sale, import, and/or
> otherwise dispose of Deliverables (or portions thereof); (c)
> distribute and have distributed to and by third parties Deliverables
> and any modifications and derivative works thereof; and (d) sublicense
> the foregoing rights set out in (a), (b) and (c) to third parties,
> including the right to license such rights to further third parties.
> Proprietary Technical Data and modifications or extensions of
> Proprietary Software not funded, developed or used in connection with
> the Subcontract are not subject to the provisions set forth above.

C.  GENERAL.

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(a) Delivery And Disclosure. Deliverables shall be delivered in
    electronic format to SAIC-F and the NCI-CBIIT by upload to GForge as
    specified in Section C, Statement of Work (Attachments 5 and 6). All
    Software Deliverables that are not source code must be accompanied
    by source code (if applicable). Furthermore, Subcontractor
    acknowledges and agrees that all Deliverables may be made available
    by NCI-CBIIT to the caBIG Community and the public by posting on the
    caBIG Community Website.

(b) License To All Deliverables. All Deliverables shall be available
    subject to the provisions of this Article H.

(c) Patent Rights. Pursuant to FAR 52.227-11, the Government shall have
    a nonexclusive, nontransferable, irrevocable, paid-up license to
    practice or have practiced for or on behalf of the United States any
    subject invention relating to any Deliverable. It is not anticipated
    that Subcontractor will file patent applications on Deliverables,
    but if it does, Subcontractor agrees that it will permit any
    Deliverables covered by patent applications or issued patents to be
    used for research or educational purposes by the caBIG Community and
    the public without charge under terms that are consistent with the
    National Institutes of Health (NIH) Principles for Recipients of NIH
    Research Grants and Contracts on Obtaining and Disseminating
    Biomedical Research Resources, 64 Fed. Reg. 72090 (Dec. 23, 1999).

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D.  SOFTWARE DELIVERABLES.

    a.  Delivery of Software Deliverables. All Software Deliverables
        shall be delivered by Subcontractor through upload to GForge as
        specified in Section C, Statement of Work (Attachments 5 and 6),
        and shall be available pursuant to the terms of this Article H.8
        and in accordance with the following additional conditions:

        1.  Subcontractor and its end-users are not authorized by the
            Subcontract to incorporate Software Deliverables into
            Proprietary Software.

        2.  In addition to distribution by NCI CBIIT on the caBIG
            Community Website, Subcontractor may distribute versions of
            Software Deliverables in its possession, but ONLY so long as
            such distribution is made under the terms of the caBIG Model
            Open Source Software License or a substantially equivalent
            agreement that is approved by the Contracting Officer.
            Subcontractor hereby acknowledges and agrees that
            Subcontractor has reviewed the terms of the caBIG Model Open
            Source Software License and understands the scope of said
            license (including the scope of patent rights granted
            therein).

        3.  Subcontractor and its end-users are expressly not authorized
            by this Subcontract to use any trademarks, service names,
            logos or product names owned by the NCI or caBIG^TM^
            Participants. It is understood that such use may be
            permitted under a separate license agreement granted by the
            NCI or caBIG^TM^ Participant to Subcontractor.

        4.  The names "The National Cancer Institute", "NCI", "Science
            Applications International Corporation," "SAIC",
            "SAIC-Frederick, Inc." and any names which Subcontractor may
            use to refer to caBIG Software and caBIG Software
            Modifications shall not be used by Subcontractor or its
            end-users to endorse or promote products derived from caBIG
            Software or caBIG Software Modifications.

    b.  Proprietary Software.

> \(1\) Proprietary Software shall not be used or delivered in
> performance of the Subcontract unless prior written permission is
> granted by the Contracting Officer to use or deliver such Proprietary
> Software and the terms of a license applicable to such Proprietary
> Software have been determined in advance.
>
> \(2\) Any Proprietary Software which is delivered with the Contracting
> Officer's approval shall be segregated from all caBIG Software that
> modifies or extends such Proprietary Software and is delivered in
> performance of the Subcontract or, if it is not, the entire product,
> including both the Proprietary Software and any caBIG Software along
> with source code, shall be delivered by upload to GForge as specified
> in Section C, Statement of Work, and subject to the provisions of this
> Article H.8. Subcontractor will be responsible for obtaining the
> rights set forth above to Proprietary Software owned or controlled by
> third parties that is used or delivered in performance of the
> Subcontract.
>
> \(3\) Modifications or extensions of Proprietary Software not funded
> and developed under the Subcontract are not subject to the provisions
> of this Article H.8.

E.  TECHNICAL DATA DELIVERABLES

    a.  All Technical Data Deliverables shall be made available pursuant
        to the terms of this Article H.8 and in accordance with the
        following additional conditions:

        1.  Subcontractor must submit a data sharing plan with any
            Technical Data Deliverables that are subject to requirements
            set forth below in Article H.8.F.

        2.  Attribution of the source of the Technical Data Deliverable
            shall be published with the Technical Data Deliverable.

> \(b\) Proprietary Technical Data.

1.  No Proprietary Technical Data may be used in connection with
    Subcontractor's performance under the Subcontract if such data are
    subject to restrictions that conflict with the provisions defined
    above UNLESS Subcontractor first receives written permission from
    the Contracting Officer to do so. Any Proprietary Technical Data
    that is used or delivered without prior permission from the
    Contracting Officer shall be subject to the provisions defined
    above. Subcontractor will be responsible for obtaining the rights to
    Proprietary Technical Data owned or controlled by third parties that
    is used or delivered in performance of the Subcontract as defined
    above.

2.  Proprietary Technical Data that are not collected, developed or used
    in connection with Subcontractor's performance under the Subcontract
    are not subject to the provisions of this Article H.

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F.  OTHER LAWS AND REGULATIONS. All Deliverables shall be provided or
    made available by Subcontractor in accordance with all applicable
    federal and state legal, regulatory and policy requirements,
    including, without limitation, HIPAA, the HIPAA Privacy and Security
    Rules, the Common Rule, FDA Regulations concerning the Informed
    Consent of Human Subjects, other FDA regulatory requirements, state
    privacy laws, and institutional review board (IRB) requirements.

PART 2---CONTRACT CLAUSES

## SECTION I---CONTRACT CLAUSES {#section-icontract-clauses .Header-2}

ARTICLE I.1. GENERAL CLAUSES

A. FEDERAL ACQUISITION REGULATION (FAR) (48 CFR CHAPTER 1) CLAUSES:

Where the words "Contracting Officer" or "Government" appear, it shall
be understood to mean "the SAIC-Frederick Contracting Officer" or "Prime
Contractor" provided; however, that such substitution in no way
supersedes or diminishes any rights or responsibilities of the
Government under public law, Federal Acquisition Regulations, or in the
terms of the prime contract, including, but not limited to, the right to
review, audit, and approve any records or procedures of the
Subcontractor. Where the word "Contractor" appears, it shall be
understood to mean "Subcontractor" and where "Contract" appears, it
shall be understood to mean "Subcontract."

This subcontract incorporates the following clauses by reference, with
the same force and effect as if they were given in full text. Upon
request, the Contracting Officer will make their full text available.
Also, the full text of a clause may be accessed electronically at this
address: http://www.arnet.gov/far/.

A. FEDERAL ACQUISITION REGULATION (FAR) (48 CFR CHAPTER 1) CLAUSES:

+---------+------------------------------------------------------------+
| **FAR** | **[Clause Title]{.underline}**                             |
|         |                                                            |
| **      |                                                            |
| [Clause |                                                            |
| No.]    |                                                            |
| {.under |                                                            |
| line}** |                                                            |
+=========+============================================================+
|         |                                                            |
+---------+------------------------------------------------------------+
| 5       | Gratuities                                                 |
| 2.203-3 |                                                            |
+---------+------------------------------------------------------------+
| 5       | Covenant Against Contingent Fees                           |
| 2.203-5 |                                                            |
+---------+------------------------------------------------------------+
| 5       | Restrictors on Subcontractor Sales to the Government       |
| 2.203-6 |                                                            |
+---------+------------------------------------------------------------+
| 5       | Anti-Kickback Procedures                                   |
| 2.203-7 |                                                            |
+---------+------------------------------------------------------------+
| 5       | Cancellation, Rescission, and Recovery of Funds for        |
| 2.203-8 | illegal or Improper Activity                               |
+---------+------------------------------------------------------------+
| 52      | Price or Fee Adjustment for Illegal or Improper Activity   |
| .203-10 |                                                            |
+---------+------------------------------------------------------------+
| 52      | Certification and Disclosure Regarding Payments to         |
| .203-11 | Influence Certain Federal Transactions                     |
+---------+------------------------------------------------------------+
| 52      | Limitation on Payments to Influence Certain Federal        |
| .203-12 | Transactions                                               |
+---------+------------------------------------------------------------+
| 52      | Contractor Code of Business Ethics and Conduct             |
| .203-13 |                                                            |
+---------+------------------------------------------------------------+
| 52      | Display of Hotline Posters                                 |
| .203-14 |                                                            |
+---------+------------------------------------------------------------+
| 5       | Printed or Copied Double-Sided on Recycled Paper           |
| 2.204-4 |                                                            |
+---------+------------------------------------------------------------+
| 5       | Protecting the Government's Interests When Subcontracting  |
| 2.209-6 | with Contractors Debarred, Suspended, or Proposed for      |
|         | Debarment                                                  |
+---------+------------------------------------------------------------+
| 5       | Audit and Records -- Negotiation                           |
| 2.215-2 |                                                            |
+---------+------------------------------------------------------------+
| 52      | Price Reduction for Defective Cost or Pricing Data         |
| .215-10 |                                                            |
+---------+------------------------------------------------------------+
| 52      | Subcontractor Cost or Pricing Data                         |
| .215-12 |                                                            |
+---------+------------------------------------------------------------+
| 52      | Integrity of Unit Prices                                   |
| .215-14 |                                                            |
+---------+------------------------------------------------------------+
| 52      | Pension Adjustments and Asset Reversions                   |
| .215-15 |                                                            |
+---------+------------------------------------------------------------+
| 52      | Reversion or Adjustment of Plans for Postretirement        |
| .215-18 | Benefits (PRB) Other than Pensions                         |
+---------+------------------------------------------------------------+
| 52      | Notification of Ownership Changes                          |
| .215-19 |                                                            |
+---------+------------------------------------------------------------+
| 52      | Requirements for Cost or Pricing Data or Information Other |
| .215-21 | Than Cost or Pricing Data---Modifications                  |
+---------+------------------------------------------------------------+
| 5       | Utilization of Small Business Concerns                     |
| 2.219-8 |                                                            |
+---------+------------------------------------------------------------+
| 5       | Small Business Subcontracting Plan                         |
| 2.219-9 |                                                            |
+---------+------------------------------------------------------------+
| 52      | Liquidated Damages---Subcontracting Plan                   |
| .219-16 |                                                            |
+---------+------------------------------------------------------------+
| 5       | Convict Labor                                              |
| 2.222-3 |                                                            |
+---------+------------------------------------------------------------+
| 52      | Prohibition of Segregated Facilities                       |
| .222-21 |                                                            |
+---------+------------------------------------------------------------+
| 52      | Affirmative Action Compliance                              |
| .222-25 |                                                            |
+---------+------------------------------------------------------------+
| 52      | Equal Opportunity                                          |
| .222-26 |                                                            |
+---------+------------------------------------------------------------+
| 52      | Equal Opportunity for Special Disabled Veterans, Veterans  |
| .222-35 | of the Vietnam Era, and Other Eligible Veterans            |
+---------+------------------------------------------------------------+
| 52      | Affirmative Action for Workers with Disabilities           |
| .222-36 |                                                            |
+---------+------------------------------------------------------------+
| 52      | Employment Reports on Special Disabled Veterans and        |
| .222-37 | Veterans of the Vietnam Era, and Other Eligible Veterans   |
+---------+------------------------------------------------------------+
| 52      | Combating Trafficking in Persons                           |
| .222-50 |                                                            |
+---------+------------------------------------------------------------+
| 5       | Drug-Free Workplace                                        |
| 2.223-6 |                                                            |
+---------+------------------------------------------------------------+
| 52      | Toxic Chemical Release Reporting                           |
| .223-14 |                                                            |
+---------+------------------------------------------------------------+
| 5       | Buy American Act---Supplies                                |
| 2.225-1 |                                                            |
+---------+------------------------------------------------------------+
| 52      | Restrictions on Certain Foreign Purchases                  |
| .225-13 |                                                            |
+---------+------------------------------------------------------------+
| 5       | Authorization and Consent, Alternate I                     |
| 2.227-1 |                                                            |
+---------+------------------------------------------------------------+
| 52      | Patent Rights---Ownership by the Contractor                |
| .227-11 |                                                            |
+---------+------------------------------------------------------------+
| 52      | Rights in Data -- General                                  |
| .227-14 |                                                            |
+---------+------------------------------------------------------------+
| 52      | Assignment of Claims                                       |
| .232-23 |                                                            |
+---------+------------------------------------------------------------+
| 52      | Bankruptcy                                                 |
| .242-13 |                                                            |
+---------+------------------------------------------------------------+
| 52      | Stop Work Order                                            |
| .242-15 |                                                            |
+---------+------------------------------------------------------------+
| 5       | Changes-Fixed Price                                        |
| 2.243-1 |                                                            |
+---------+------------------------------------------------------------+
| 5       | Subcontracts                                               |
| 2.244-2 |                                                            |
+---------+------------------------------------------------------------+
| 5       | Government Property                                        |
| 2.245-1 |                                                            |
+---------+------------------------------------------------------------+
| 5       | Use and Charges                                            |
| 2.245-9 |                                                            |
+---------+------------------------------------------------------------+
| 5       | Inspection of Services -- Fixed-Price                      |
| 2.246-4 |                                                            |
+---------+------------------------------------------------------------+
| 52      | Limitation of Liability -- Services                        |
| .246-25 |                                                            |
+---------+------------------------------------------------------------+

B. DEPARTMENT OF HEALTH AND HUMAN SERVICES ACQUISITION REGULATION
(HHSAR) (48 CHAPTER 3) CLAUSES:

This subcontract incorporates the following DEPARTMENT OF HEALTH AND
HUMAN SERVICES ACQUISITION REGULATION HHSAR 48 Chapter 3 clauses by
reference, with the same force and effect as if they were given in full
text. Upon request, the Contracting Officer will make their full text
available. Also, the full text of a clause may be accessed
electronically at this address: <http://www.hhs.gov/oamp/dap/hhsar.html>

  ----------------------------------------------------------------------------------
  **HHSAR [Clause      **[Clause Title]{.underline}**
  No.]{.underline}**   
  -------------------- -------------------------------------------------------------
  352.249-14           Excusable Delays

  352.270-5            Key Personnel

  352.270-7            Paper Reduction Act
  ----------------------------------------------------------------------------------

\[End of GENERAL CLAUSES\]

ARTICLE I.2. CLAUSES PROVIDED IN FULL TEXT

**FAR 52.227-11 Patent Rights---Retention by the Contractor (Short
Form)**

As prescribed in 27.303(a), insert the following clause:

PATENT RIGHTS---RETENTION BY THE CONTRACTOR (SHORT FORM) (JUNE 1997)

\(j\) *Communications*.

All invention disclosures and requests for greater rights shall be sent
to the Contracting Officer. Additionally, a copy of all invention
disclosures, confirmatory licenses to the government, face page of the
patent applications, waivers and other routine communications should
send to the Contracting Officer and the Director, Office of Extramural
Research Administration, Division of Extramural Inventions and
Technology Resources, National Institutes of Health, 6701 Rockledge
Drive, Room 1136, Bethesda, MD 20892-7750 or
[www.iEdison.gov](http://www.iedison.gov/) citing the SAIC-Frederick
contract number NO1-CO-12400.

(END OF CLAUSE)

PART 3---LIST OF DOCUMENTS, EXHIBITS AND OTHER ATTACHMENTS

## SECTION J---LIST OF ATTACHMENTS {#section-jlist-of-attachments .Header-2}

ARTICLE J.1. ATTACHMENTS

  ------- ----------- -------------------------------------------------------------
  1\.                 SAIC Frederick Terms and Conditions (*dated 10/2007)*

                      

  2\.                 SAIC-Frederick, Inc. Invoice Instructions

                      

  3\.                 Subcontracting Certification

                      

  4\.                 Price Proposal

                      

  5\.     []{.mark}   Section C -- RFP Statement of Objectives

          []{.mark}   []{.mark}

  6\.     []{.mark}   Subcontractor Statement of Work (upon Award)
  ------- ----------- -------------------------------------------------------------

PART 4---REPRESENTATIONS AND INSTRUCTIONS

##  {#section-5 .Header-2}

## SECTION K---REPRESENTATIONS, CERTIFICATIONS AND OTHER STATEMENTS OF OFFERORS {#section-krepresentations-certifications-and-other-statements-of-offerors .Header-2}

In order to be considered responsive an Offer provided in response to
this solicitation must include complete and accurate Representations and
Certifications in one of the two manners indicated in this section. If
the Offeror is registered and current with the Online Representations
and Certification Application (ORCA) website (<https://orca.bpn.gov/> )
then only the provision of a current Dun & Bradstreet (DUNS) number is
required and should be provided below. If the Offeror is not registered
and current with ORCA, the Offeror must submit a completed and signed
hard copy of the Representations and Certifications which may be
accessed and printed from
<http://rcb.cancer.gov/rcb-internet/forms/rcneg.pdf>.

.

Please indicate your organization's status by checking the appropriate
response:

> Our organization is registered and current with ORCA; our DUNS number
> is \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_ .
>
> Our organization is NOT registered with ORCA; we have submitted one
> copy of the Representations and Certifications with our proposal.

## SECTION L --- INSTRUCTIONS, CONDITIONS, AND NOTICES TO OFFERORS {#section-l-instructions-conditions-and-notices-to-offerors .Header-2}

ARTICLE L.1. PROPOSAL PREPARATION INSTRUCTIONS

A. Authorizing Official:

> An official authorized to contractually bind your organization must
> sign the proposals submitted.

B. Format:

# 1. Proposals shall be submitted electronically via e-mail to Jennifer Thomas [thomasjennifer@mail.nih.gov](mailto:thomasjennifer@mail.nih.gov?subject=Solicitation No. S09-094). The files shall be saved and submitted as both Adobe Acrobat and Microsoft Word documents and named as follows:

**Volume 1 -- Solicitation**

> This file shall contain the solicitation document with all items
> completed as requested in Article L.2. Volume 1 -- Solicitation
> proposal instructions below and be named Volume 1 -- Solicitation.
>
> **Volume 2 -- Technical Proposal**
>
> This file shall contain all items as required in L.3. Volume 2 --
> Technical Proposal instructions below and be named Volume 2 --
> Technical Proposal**.**
>
> **Volume 3 -- Price Proposal**
>
> This file shall contain the price proposal as requested in Article
> L.4. Volume 3 -- Price Proposal instructions below and be named Volume
> 3 -- Price Proposal.

1.  Elaborate brochures or other presentations beyond those sufficient
    to present a complete and effective response to this solicitation
    are not desired.

2.  Proposal preparation costs are the responsibility of the Offeror.

3.  ALL QUESTIONS OR REQUESTS FOR CLARIFICATIONS MUST BE E-MAILED TO
    Jennifer Thomas at
    [thomasjennifer@mail.nih.gov](mailto:thomasjennifer@mail.nih.gov?subject=Solicitation S09-094)
    **BEFORE 4:00 P.M., EASTERN STANDARD TIME, JANUARY 4, 2009**.
    Questions or requests directed to any other individual or outside
    the directives of this Solicitation will not be considered valid,
    nor will there be a response provided.

4.  **ALL PROPOSALS MUST BE RECEIVED NO LATER THAN 4:00 P.M., EST,
    FEBRUARY 5, 2009**. Proposals shall be submitted electronically via
    e-mail to Jennifer Thomas at
    [**thomasjennifer@mail.nih.gov**](mailto:thomasjennifer@mail.nih.gov?subject=Solicitation S09-094).

ARTICLE L.2. VOLUME 1 -- SOLICITATION

The Offeror shall electronically submit the solicitation in its entirety
with the following items completed and included:

1.  Signed Cover Page with Boxes 16, 17, 18, 19, and 20 completed
    including the Offeror's DUNS Number

2.  Pages 8 and 9 completed designating Subcontractor Authorized
    Representative, Subcontractor Authorized Invoice Administrator, and
    Key Personnel.

3.  Section K -- Representations, Certifications, and Other Statements
    of Offerors completed and signed (see Section K on Page 20).

4.  If the total price proposed exceeds \$550,000, Attachment 3 --
    Subcontracting Certification needs to be completed and submitted
    with offer**.**

5.  A completed Form W-9 is required to be submitted with Offer. All
    Offeror's MUST be registered with the Central Contractors
    Registration (CCR). Offerors may register with CCR at
    <http://www.ccr.gov/Start.aspx>. The address included on the W-9
    MUST match the address registered at CCR, ORCA, and/or included on
    hard copy of Representations, Certifications, and Other Statements
    of Offerors.

ARTICLE L.3. VOLUME 2 -- TECHNICAL PROPOSAL

The Offeror's Technical Proposal shall contain at a minimum the
following:

**Draft Research Plan**

The Offeror shall provide a draft research plan containing all elements
described in Task 4 of Attachment 5. In addition, a proposed research
program consisting of a proposed line of research, a specific first
experiment to be undertaken, and potential follow on projects shall be
described. The innovative features of the experimental line shall be
clearly described. The first experiment shall be described in detail in
the draft plan. Methods to be used to accomplish the first experiment
must be clearly defined including the planned data sources and tools to
be used. Products shall also be described.

**Draft Data Sharing Plan**

The Offeror shall present a draft data sharing plan as described in Task
3 of Attachment 5 specifying the research resources and research
products to be shared and describing the timing and mechanisms by which
the Offeror will make available both any research resources that are not
publicly available as well as any resulting research products. As
described in Section M -- Evaluation Factors for Award, adequacy of the
draft data sharing plan will be considered when proposals are scored.

Successful Offerors will have their data sharing plan reviewed by the
SAIC-F COTR, NCI PO and the caBIG Data Sharing and Intellectual Capital
(DSIC) Workspace Facilitator; comments should be incorporated and the
final data sharing plan provided within 90 days of the subcontract award
date. Compliance with the final data sharing plan, as may be revised
during the negotiation process between the Offeror and the SAIC-F COTR,
shall become a material requirement of the subcontract. The final data
sharing plan may be further revised by the parties from time to time as
needed in order to reflect research resources and research products
associated with subsequent research investigations.

Draft Project Management Plan

The Offeror shall describe the overall project plan for the base period
including sufficient detail describing the overall technical approach,
understanding of the objectives, and proposed time line for completing
specific requirements and tasks. The Draft Project Management Plan shall
contain all elements as described in Attachment 5.

Proposed Personnel

The proposal shall address all relevant elements described in the
Section M -- Evaluation Factors for Award.

Past Experience

The proposal shall address all relevant elements described in Section M
-- Evaluation Factors for Award.

Government Furnished Equipment (GFE)/Government Furnished Information
(GFI)

Describe all Government Furnished Equipment (GFE) and Government
Furnished Information (GFI) that is required to accomplish the Tasks
described in Attachment 5. For Each GFE/GFI, describe its importance to
the project and implications for the work if it is not made available.
The plan to acquire each requested GFE/GFI shall also be given.

ARTICLE L.4. VOLUME 3 -- PRICE PROPOSAL

The NCI's Center for Biomedical Informatics and Information Technology
anticipates total funding for this effort to be \$3.5 Million dollars
for a 12-Month period of performance. It is expected that this
solicitation will result in a minimum of five (5) subcontract awards.
Price Proposals shall include anticipated personnel, labor hours, rates,
and basis of estimate for all tasks outlined in Attachment 5. As
indicated in Section M -- Evaluation Factors for Award, price will not
be explicitly scored, but the cost reasonableness will be evaluated.

## To be considered responsive to this RFP, Offerors must include a completed, comprehensive Milestone and Payment Schedule (See Attachment 5, Section 6.3 for example) for each potential subcontract period (i.e. base period, option period one and option period two) as well as the associated price justifications described in Section M.4 below. {#to-be-considered-responsive-to-this-rfp-offerors-must-include-a-completed-comprehensive-milestone-and-payment-schedule-see-attachment-5-section-6.3-for-example-for-each-potential-subcontract-period-i.e.-base-period-option-period-one-and-option-period-two-as-well-as-the-associated-price-justifications-described-in-section-m.4-below. .Header-2}

See Attachment 4 -- for Price Proposal Template.

ARTICLE L.5. POINT OF CONTACT

The Subcontracts Specialist for this solicitation is identified below.

Jennifer Thomas

SAIC-Frederick, Inc.

P.O. Box B

Frederick, Maryland 21702-1201

Phone: 301-228-4004; Fax: 301-228-4037

E-mail: <thomasjennifer@mail.nih.gov>

##  {#section-6 .Header-2}

##  {#section-7 .Header-2}

## SECTION M \-- EVALUATION FACTORS FOR AWARD {#section-m----evaluation-factors-for-award .Header-2}

ARTICLE M.1. EVALUATION FACTORS FOR AWARD

The assessment of Offers received in response to this solicitation will
be carefully considered against the needs of SAIC-Frederick, Inc.
(SAIC-Frederick) and the NCI Center for Biomedical Informatics and
Information Technology. This assessment is not intended to be a solely
mechanical or mathematical analysis of an Offer, but rather the product
of both objective and subjective measurements and judgments of the
source selection officials after consideration of the relevant
information.

**[Basis for Award:]{.underline}**

SAIC-Frederick will award approximately five subcontracts resulting from
this RFP to the responsible organizations whose offers conforming to the
RFP will be the most advantageous to the SAIC-Frederick, price and other
factors considered.

**[Potential Award Without Discussions:]{.underline}**

SAIC-Frederick reserves the right to award a subcontract without
discussions if the Contracting Officer determines that the initial
prices are fair and reasonable and that discussions are not necessary.

Therefore, the Offeror's initial offer should contain the Offeror's best
terms from a price and technical standpoint. However, SAIC-Frederick
reserves the right to conduct discussions if later determined by the
Contracting Officer to be necessary. SAIC-Frederick may reject any or
all proposals if such action is in the public interest; accept other
than the lowest price; and waive informalities and minor irregularities
in proposals received.

**[Evaluation Factors:]{.underline}**

In descending order of relative importance, the following factors shall
be used to evaluate the prospective Offers:

1.  Scientific Merit/Technical Plan

2.  Personnel

3.  Past Performance

4.  Scope of Work

**(1) Scientific Merit/Technical Plan**

Proposals will be judged primarily on the basis of their Scientific
Merit. The primary criteria for the proposed work will include:

-   Importance of the research problems relevant to the mission of the
    National Cancer Institute

-   Advancement of scientific knowledge or clinical practice if the aims
    of the research are achieved

-   Effects on the concepts, technologies, treatments, services, or
    preventative interventions that drive contemporary oncology

In addition the following will be judged as part of the Scientific Merit
of the proposed research;

-   Adequacy of the plan to use and make openly available caBIG and
    other public or private research resources (according to the data
    sharing plan)

-   Adequacy of the planned research products

-   Adequacy of the plans and procedures for public release of the
    planned research products according to the data sharing plan

-   Adequacy of the plans to add to capabilities available through caBIG
    such as a Grid node that provides access to interesting data and/or
    novel analysis or data mining capabilities.

**(2) Personnel**

Describe the personnel who will be assigned to both manage and perform
the work under this proposed subcontract. Resume summaries for at least
3 personnel, including the ISRCE Director and Principal Investigator
(who may be the same person) as Key Personnel, are required that will
show each person\'s general qualifications and recent experience with
similar research. The role each person is to play shall be described.

Personnel described should demonstrate (in aggregate) at least the
following:

1.  Skills in bioinformatics, computational biology and/or systems
    biology research

2.  A track record of participating in or forming research
    collaborations

3.  A track record in sharing data and/or providing open source
    algorithms and tools

4.  Knowledge of project management and managing research efforts of
    this size and/or scope

**(3)** **Past Performance**

The past performance shall demonstrate the Offeror's background and the
experience of the proposed personnel in conducting research activities
of this size and/or complexity. The Offeror shall describe at least 3
examples of similar research performed by proposed team members in the
past. For each research example, provide research and findings summary,
value, period of performance, and contact information for the Agency,
Project and/or Contracting Officer's Technical Representative for the
grant or contract that funded the work.

In addition, the Offeror's proposal shall explicitly address the
following;

Demonstration of preexisting knowledge of publications and curated
biomedical databases; knowledge of other publicly and privately
available data sets and tools to collect, utilize, manage data stores,
and interpret data at several points and levels of analysis along a
hypothesis driven bioinformatics pipeline; technical expertise in data
integration and analysis across different data types; skills in using
caBIG infrastructure, data sets and tools.

**(4) Cost Realism**

Price will not be explicitly scored. However, the scope of work that is
proposed will be considered in comparison to the price offered.
Therefore, offerors shall clearly justify the proposed price in terms of
the proposed work to be performed. **This justification must include a
basis of estimate for each milestone proposed and shall be so
substantive as to enable SAIC-F to determine that the prices proposed
are fair and reasonable when considered against the work to be
undertaken.**

**SAIC-F reserves the right to request additional information in order
to make this determination and to forgo award if unable to do so.**

## ATTACHMENT 1 {#attachment-1 .Header-2}

SAIC-FREDERICK TERMS AND CONDITIONS

#### October 2007

SAIC-Frederick, Inc.

A subsidiary of Science Applications International Corporation

**TERMS AND CONDITIONS**

**October 2007**

**1. GOVERNMENT RELATIONSHIP**

This Order is made by SAIC-Frederick, Inc., a Subsidiary of Science
Applications International Corporation under its contract with the
National Cancer Institute at Frederick (NCI-Frederick). The provisions
and clauses contained herein are influenced by and reflect the
relationship of the parties in that contract, which was awarded and is
administered under the provision of the Federal Acquisition Regulation
(FAR). There is no privity of contract between the Seller and the
Government.

2.  **GENERAL RELATIONSHIP**

The Seller is not an employee of SAIC-Frederick, Inc. for any purpose
whatsoever. Seller agrees that in all matters relating to this Order it
shall be acting as an independent contractor and shall assume and pay
all liabilities and perform all obligations imposed with respect to the
performance of this Order. Seller shall have no right, power or
authority to create any obligation, expressed or implied, on behalf of
Buyer and/or Buyer's customers and shall have no authority to represent
Buyer as an agent.

3.  **DEFINITIONS**

Buyer -- SAIC-Frederick, Inc.

Seller -- The party (contractor) receiving the award from
SAIC-Frederick, Inc.

Prime Contract − The Government contract under which this Order is
issued (see paragraph 1 entitled \"Government Relationship\").

NCI Government Contracting Officer −The NCI-Frederick person with the
authority to interpret, modify, administer, and/or otherwise make
decisions with regard to the Prime Contract\". This term includes
authorized representatives of the NCI-Frederick Contracting Officer
within their delegated authority.

Contracting Officer -- The SAIC-Frederick, Inc. person with the
authority to enter into and administer Orders. The term includes
authorized representatives of the Contracting Officer acting within
their delegated authority.

Order -- The contractual agreement between SAIC-Frederick, Inc. and the
Seller.

Special Definitions -- See paragraph 4 for the special definitions that
apply in the use of the solicitation and award clauses of this Order.

4.  **SOLICITATION AND AWARD CLAUSES -- SPECIAL DEFINITIONS**

FAR clauses included in this Order, including any solicitation document,
shall be interpreted as follows:

Unless a purposeful distinction is made clear and the context of the
clause requires retention of the original definition, the term
"Contractor" shall mean Seller, the term "Contract" shall mean this
Order, the term "Subcontractor" shall mean Subcontractors of Seller at
any tier, and the terms "Government", "Contracting Officer" and
equivalent phrases shall mean SAIC-Frederick, Inc. and SAIC-Frederick's
Contracting Officer, respectively. It is intended that the referenced
clauses shall apply to Seller in such manner as is necessary to reflect
the position of Seller as a contractor to SAIC-Frederick, Inc. to insure
Seller's obligations to SAIC-Frederick, Inc. and to the United States
Government, and to enable SAIC-Frederick, Inc. to meet its obligations
under its Prime Contract.

Full text of the referenced clauses may be found in the FAR (Code of
Federal Regulation \[CFR\] Title 48), obtainable from the Superintendent
of Documents, Government Printing Office (GPO), Washington, DC 20402 or
online at <http://www.arnet.gov/far/>. Copies of the clauses will be
furnished by the Contracting Officer upon request.

**5. ENTIRE AGREEMENT**

This Order, including all attachments and/or documents incorporated by
reference by Buyer, shall constitute the entire agreement between Buyer
and Seller. No other document (including Seller's proposal, quotation or
acknowledgement forms, etc.) shall be a part of this Order, even if
referred to, unless specifically agreed to in writing by Buyer. No right
that Buyer has regarding this Order may be waived or modified except in
writing by Buyer.

**6. ACCEPTANCE AND MODIFICATION OF TERMS**

Acceptance of this Order by Seller may be made by signing the
acknowledgement copy hereof or by partial performance hereunder, and any
such acceptance shall constitute an unqualified agreement to all terms
and conditions set forth herein unless otherwise modified in writing by
the parties. Any additions, deletions or differences in the terms
proposed by Seller are objected to and hereby rejected, unless Buyer
agrees otherwise in writing. No additional or different terms and
conditions proposed by the Seller in accepting this Order shall be
binding upon Buyer unless accepted in writing by Buyer and no other
addition, alteration or modification to, and no waiver of any of the
provisions herein contained shall be valid unless made in writing and
executed by Buyer and Seller. Seller shall perform in accordance with
the Description/Quantity schedule set forth in this Order and all
attachments thereto.

**7. LEGAL CONSTRUCTION AND INTERPRETATIONS**

This Order shall be governed by and interpreted in accordance with the
principles of Federal Contract Law, and to the extent that Federal
Contract Law is not dispositive, and the state law becomes applicable,
the law of the State of Maryland shall apply.

**8. COMPLIANCE WITH LAWS AND REGULATIONS**

Seller shall submit all certifications required by Buyer under this
Order and shall at all times, at its own expense, comply with all
applicable Federal, State and local laws, ordinances, administrative
orders, rules or regulations.

**9. GIFTS**

Seller shall not make or offer a gratuity or gift of any kind to Buyer's
employees or their families. Seller should note that the providing of
gifts or attempting to provide gifts under government subcontracts might
be a violation of the Anti-Kickback Act of 1986 (4 U.S.C. 51-58).

10. **MARYLAND SALES AND USE TAX**

The State of Maryland has issued Direct Payment Permit #3, effective
date August 29, 1996, to SAIC-Frederick, Inc. that will be issued to
vendors of NCI-Frederick for purchases of goods and services. A copy of
this Permit is available to vendors upon request. As a holder of a
Direct Payment Permit, SAIC-Frederick, Inc. is authorized to make direct
payment of sales and use tax to the State of Maryland. Accordingly,
sellers that provide goods and services to SAIC-Frederick, Inc. are
relieved from collecting sales tax from SAIC-Frederick, Inc. Therefore,
sellers to SAIC-Frederick, Inc. shall not place a separate line item for
tax on any invoice sent to SAIC-Frederick, Inc. Please note that the
Permit is not to be used by sellers to make purchases free of sales tax,
nor shall the Permit be transferred or assigned.

**11. BUYER FURNISHED DATA AND MATERIALS**

Seller agrees that it will keep confidential and not disclose,
disseminate or publish the features of any equipment, tools, gauges,
patterns, designs, drawings, engineering data, computer programs and
software or other technical or proprietary information furnished, loaned
or bailed by Buyer hereunder (hereinafter collectively referred to as
(items/information), and will use such items/information only in the
performance of this Order or, if authorized, other orders from Buyer,
and not otherwise without Buyer's written consent.

All such items furnished, loaned or bailed by Buyer hereunder, or
fabricated, manufactured, purchased, or otherwise acquired by Seller for
the performance of this Order and specifically charged to Buyer, are the
property of Buyer.

Upon completion, expiration or termination of this Order, Seller shall
return all such items in good condition, reasonable wear only excepted,
together with all spoiled and surplus items to Buyer, or make such other
disposition thereof as may be directed or approved by Buyer. Seller
agrees to replace, at its expense, all such items not so returned.
Seller shall make no charge for any storage, maintenance or retention of
such items. Seller shall bear all risk of loss for all such items in
Seller's possession.

Seller also agrees to use any designs or data contained or embodied in
such items in accordance with any restrictive legends placed on such
items by Buyer or any third party. If Buyer furnishes any material, for
fabrication hereunder, Seller agrees: (a) not to substitute any other
material for such fabrication with Buyer's prior written consent, and
(b) that title to such material shall not be affected by incorporation
in or attachment to any other property.

**12. NOTICE OF DELAY**

Seller agrees to immediately notify Buyer in writing of any actual or
potential delay in Sellers performance under this Order. Such notice
shall, at a minimum, describe the cause, effect, duration and corrective
action proposed by Seller to address the problem. Seller shall give
prompt written notice to the Buyer of all changes to such conditions.

13. **CHANGES AND SUSPENSION**

Buyer may, by written notice to Seller at any time, make changes within
the general scope of this Order in any one or more of the following: (a)
drawings, designs or specifications; (b) quantity; (c) time or place of
delivery; (d) method of shipment or packing; and (e) the quantity of
Buyer furnished property. Buyer may, for any reason, direct Seller to
suspend, in whole or in part, delivery of goods or performance of
services hereunder for such period of time as may be determined by Buyer
in its sole discretion. If any such change or suspension causes a
material increase or decrease in the cost of, or the time required for
the performance of any part of the work under this Order, an equitable
adjustment shall be made in the Order price or delivery schedule, or
both, provided Seller shall have notified Buyer in writing of any claim
for such adjustment within twenty (20) days from the date of
notification of the change or suspension from Buyer. No such adjustment
or any other modification of the terms of this Order will be allowed
unless authorized by Buyer by means of a written modification to the
Order. Seller shall proceed with the work as changed without
interruption and without awaiting settlement of any such claim.

**14. ADVERTISING**

Seller agrees that prior to the issuance of any publicity or publication
of any advertising that in either case makes reference to this Order, or
to Buyer, Seller will obtain the written permission of Buyer with
respect thereto.

**15. CONFIDENTIAL INFORMATION**

Seller shall not at any time, even after the expiration or termination
of this Order, use or disclose to any person for any purpose other than
to perform this Order, any information it receives, directly or
indirectly from Buyer in connection with this Order, except information
that is or becomes publicly available, or is rightfully received by
Seller from a third party without restriction. Upon request by Buyer,
Seller shall return to Buyer all documentation and other material
containing such information.

**16. INDEMNIFICATION**

Seller shall indemnify, defend and hold harmless Buyer from and against
any and all claims, liabilities, damages, losses, causes of action,
lawsuits, costs and expenses, including reasonable attorneys' fees and
litigation costs incurred in connection therewith and regardless of
legal theory (hereinafter referred to as "claims"), occasioned wholly or
in part by any act or omission of Seller or any of its lower tiers, or
their employees, agents or representatives arising out of or relating to
this Order. Notwithstanding the foregoing, Seller's obligations under
this Section shall not apply to any claims that are finally determined
by a court of competent jurisdiction to be occasioned solely by the
negligence or willful misconduct of Buyer.

17. **INFRINGEMENT INDEMNITIES**

Seller shall, at its expense, indemnify, defend, save and hold Buyer and
its successors, affiliates, officers, directors, employees, agents,
independent contractors and customers, and the officers, agents and
employees of such customers (hereinafter collectively referred to in
this section as "Buyer") harmless from and against any and all damages,
liabilities, penalties, interest and costs awarded against and
reasonable expenses, including without limitation attorneys' fees that
result or arise out of or relate to, in whole or part, any claims,
suits, proceedings, actions, causes of action and demands brought
against the Buyer asserting that the deliverables, including without
delivery, including without limitation all software, goods or services,
or any part thereof, furnished under this Order, or the creation,
delivery, use modification, reproduction, release, performance, display
or disclosure, including without limitation resale or sublicensing
thereof, constitutes an infringement of any patent, trademark, trade
secret, copyright or other proprietary or intellectual property right or
rights of privacy or publicity. In the event such goods or services or
use thereof are enjoined in whole or in part, Seller shall at its
expense and Buyer's option undertake one of the following: (a) obtain
for Buyer the right to continue the use of such goods or services; (b)
in a manner acceptable to Buyer, substitute equivalent goods or services
or make modifications thereto so as to avoid such infringement and
extend this indemnity thereto; or (c) refund to Buyer an amount equal to
the purchase price for such goods or services plus any excess costs or
expenses incurred in obtaining substitute goods or services from another
source.

Notwithstanding this Section 17, should the deliverables or portion
thereof be held to constitute an infringement and use as contemplated by
this Order be enjoined or be threatened to be enjoined, Seller shall
notify Buyer and immediately, at Seller's expense; (a) procure for Buyer
the right to continue to use the deliverables or portion thereof with a
version that is non-infringing, provided that the replacement or
modified version meets any applicable specifications to Buyer's
satisfaction. If (a) or (b) are not available to Seller, in addition to
any damages or expenses reimbursed under this section, Seller shall
refund to Buyer all amounts paid to Seller by Buyer under this Order.

**18. NON-WAIVER OF RIGHTS**

The failure of Buyer to insist upon strict performance of any of the
terms and conditions in this Order or to exercise any rights or
remedies, shall not be construed as a waiver of its rights to assert any
of same or to rely on any such terms or conditions at any time
thereafter. Acceptance or payment of any part of the Order shall not
bind Buyer to accept future shipments or performance of services nor
deprive Buyer of the right to return goods already accepted or for which
Buyer has made payment. Acceptance or payment shall not be deemed to be
a waiver of Buyer's right to cancel or return all or any part of the
goods because of failure to conform to the Order or by reason of
defects, whether latent or patent, or other breach of warranty, or to
make any claim for damages of any and all kind.

**19. INSURANCE REQUIREMENTS FOR WORK ON A GOVERNMENT INSTALLATION**

If this Order entails effort on a Government installation, including any
off-site buildings owned or leased by the Government, the Seller must
provide and maintain the minimum amounts of insurance stated below.

At Buyer's request, Seller agrees to provide Certificates of Insurance
evidencing that the required insurance coverages are in force and
providing not less than thirty days written notice prior to any
cancellation or restrictive modification of the policies.

Further, the required insurance coverages below shall be primary and
non-contributing with respect to any other insurance that may be
maintained by Buyer. The below required coverages and their limits in no
way lessen nor affect Seller's other obligations or liabilities set
forth in this Order.

> Seller agrees to purchase and maintain at its own expense the
> following insurance coverages with minimum limits as stated:

a.  Statutory Workers' Compensation and Employer's Liability in an
    amount no less than \$1 Million per occurrence covering its
    employees, including a waiver of subrogation obtained from the
    carrier in favor of Buyer;

b.  Commercial General Liability in an amount no less than \$1 Million
    per each occurrence and \$2 Million in this Aggregate covering
    bodily injury, broad form property damage, personal injury, products
    and completed operations, contractual liability and independent
    contractors' liability. Buyer, its officers and employees shall be
    included as Additional Insureds and a waiver of subrogation shall be
    obtained from the carrier in favor of Buyer;

c.  Automobile Liability in an amount no less than \$1 Million Combined
    Single Limit for Bodily Injury covering use of all owned, non-owned,
    and hired vehicles. Buyer, its officers and employees shall be
    included as Additional Insureds on the policy;

d.  Professional Liability in an amount no less than \$1 Million per
    occurrence covering damages caused by any acts, errors, and
    omissions arising out of the professional services performed by
    Seller, or any person for whom the Seller is legally liable. To the
    extent that coverage for Seller's services are not excluded in (ii)
    above by virtue of being deemed not of a professional nature, this
    requirement does not apply.

e.  All-Risk Property Insurance in an amount adequate to replace
    property, including supplies covered by this Order, of Buyer and/or
    Buyer's customer that may be in the possession or control of Seller.
    Buyer shall be named as a Loss Payee with respect to loss or damage
    to said property and/or supplies furnished by Buyer.

The required insurance coverages above shall be primary and
non-contributing with respect to any other insurance that may be
maintained by Buyer and notwithstanding any provision contained herein,
Seller, and its employees, agents, representatives, consultants,
Subcontractors and suppliers, are not insured by the Buyer, and are not
covered under any policy of insurance that the Buyer has obtained or has
in place.

Any self-insured retentions, deductibles and exclusions in coverage in
the policies required under this Article shall be assumed by, for the
account of, and at the sole risk of Seller which provides the insurance
and to the extent applicable shall be paid by Seller. In no event shall
the liability of Seller be limited to the extent of any insurance or the
minimum limits required herein.

**20. EXPORT CONTROL COMPLIANCE FOR FOREIGN PERSONS**

Seller shall not, nor shall Seller authorize or permit its employees,
agents or lower tiers to disclose, export or re-export any Buyer
information, or any process, product or services that is produced under
this Order, without prior notification to Buyer and complying with all
applicable Federal, State and local laws, regulations and ordinances,
including the regulations of the U.S. Department of Commerce and/or the
U.S. Department of State. In addition, Seller agrees to immediately
notify Buyer if Seller is listed on any of the Department of State,
Treasury or Commerce proscribed persons or destinations lists, or if
Seller's export privileges are otherwise denied, suspended or revoked in
whole or in part.

Under its contract with NCI-Frederick, Buyer conducts research
activities that include export-controlled technology that cannot be
readily segregated. Buyer may require Seller (including any lower tiers)
to place restrictions on their work force performing onsite at
SAIC-Frederick, Inc. to protected individuals as established under the
guidelines of the Commerce Department Export Administration Regulations
(EAR) and the State Department International Traffic in Arms Regulations
(ITAR).

Contractors (including any lower tiers) may be required to disclose the
status of personnel proposed to perform work onsite prior to award.

Contractors shall include in all agreements and related documents with
lower tiers, notice to third parties that the export of any process,
goods and/or technical data from the United States may require an export
control license from the U.S. Government and that, failure to obtain
such export control license may result in termination of Order, and/or
criminal liability under U.S. laws.

**21. ASSIGNMENT**

Neither this Order nor any interest herein may be assigned, in whole or
in part, without the prior written consent of Buyer except that the
Seller shall have the right to assign this Order to any successor of
such party by way of merger or consolidation or the acquisition of
substantially all of the business and assets of the Seller relating to
the subject matter of this Order. This right shall be retained provided
that such successor shall expressly assume all of the obligations and
liabilities of the Seller under this Order, and that the Seller shall
remain liable and responsible to Buyer for the performance and
observance of all such obligations.

Notwithstanding the foregoing, any amounts due the Seller may be
assigned in accordance with the provisions of the clause 52.232-23,
Assignment of Claims.

In the event the prime contract of SAIC-Frederick, Inc. with the
Government is succeeded by a successor contractor selected by the
Government, this Order may be assigned to the successor contractor.

**22. DISPUTES**

\(A\) If a decision relating to the Prime Contract is made by the
NCI-Frederick Contracting Officer and such decision is also related to
this Order, said decision, if binding upon Buyer under the
Prime Contract shall in turn be binding upon Buyer and Seller with
respect to such matter; provided, however, that if Seller disagrees with
any such decision made by the NCI Contracting Officer and Buyer elects
not to appeal any such decision, Seller shall have the right reserved to
Buyer under the Prime Contract with the Government to prosecute a timely
appeal in the name of Buyer, as permitted by the contract or by law,
Seller to bear its own legal and other costs. If Buyer elects not to
appeal any such decision, Buyer agrees to notify Seller in a timely
fashion after receipt of such decision and to assist Seller in its
prosecution of any such appeal in every reasonable manner. If Buyer
elects to appeal any such decision of the NCI Contracting Officer, Buyer
agrees to furnish Seller promptly of a copy of such appeal. Any decision
upon appeal, if binding upon Buyer, shall in turn be binding upon
Seller. Pending the making of any decision, either by the NCI
Contracting Officer or on appeal, Seller shall proceed diligently with
performance of this Order.

If, as a result of any decision or judgment whish is binding upon Seller
and Buyer, as provided above, Buyer is unable to obtain payment or
reimbursement from the Government under the Prime Contract for, or
is required to refund or credit to the Government, any amount with
respect to any item or matter for which the Buyer has reimbursed or paid
Seller, Seller shall, on demand, promptly repay such amount to Buyer.
Additionally, pending the final conclusion of any appeal hereunder,
Seller shall, on demand promptly repay any such amount to Buyer.
Buyer\'s maximum liability for any matter connected with or related to
this Order which was properly the subject of a claim against the
Government under the Prime Contract shall not exceed the amount of the
Buyer\'s recovery from the Government.

Seller agrees to provide certification that data supporting any claim
made by Seller hereunder is made in good faith and that the supporting
data is accurate and complete to the best of the Seller\'s knowledge or
belief, all in accordance with the requirements of the Contracts
Disputes Act of 1978 (41USC601-613) and implementing regulations. If any
claim of Seller is determined to be based on upon fraud or
misrepresentation, Seller agrees to defend, indemnify, and hold Buyer
harmless for any and all liability, loss, cost, or expense resulting
there from.

Any dispute not addressed in paragraph (A) above, will be subject to
paragraph (B) as described below.

\(B\) Buyer and Seller agree to first enter into negotiations to resolve
any controversy, claim or dispute ("dispute") arising under or relating
to this Order. The parties agree to negotiate in good faith to reach a
mutually agreeable resolution of such dispute within a reasonable period
of time. If good faith negotiations are unsuccessful, Buyer and Seller
agree to resolve the dispute by binding and final arbitration in
accordance with the Commercial Arbitration Rules of the American
Arbitration Association then in effect. The arbitration shall take place
in the County of Frederick, State of Maryland. The arbitrator(s) shall
be bound to follow the provisions of this Order in resolving the
dispute, and may not award punitive damages. The decision of the
arbitrator(s) shall be final and binding on the parties, and any award
of the arbitrator(s) may be entered or enforced in any court of
competent jurisdiction.

Seller hereby waives any immunity, sovereign or otherwise, that it would
otherwise have to such jurisdiction and agrees that its rights,
obligations, and liabilities hereunder shall be determined in the same
manner and to the same extent as those of a private litigant under like
circumstances.

All costs of the arbitration shall be shared equally between the
Parties, but the Parties specifically agree that each Party shall bear
the expense of any costs incurred by it for its own counsel, experts,
witnesses, preparation of documents, presentations, and logistics
related to the proceedings.

Pending any decision, appeal or judgment referred to in this provision
or the settlement of any dispute arising under this Order, Seller shall
proceed diligently with the performance of this Order.

**23. NOTIFICATION OF DEBARMENT/SUSPENSION**

By acceptance of this Order either in writing or by performance, Seller
certifies that as of the date of award of this Order neither the Seller,
lower tiers, nor any of its principals, is debarred, suspended, or
proposed for debarment by the Federal Government. Further, Seller shall
provide immediate written notice to the Buyer in the event that during
performance of this Order the Seller or any of its principals is
debarred, suspended, or proposed for debarment by the Federal
Government.

**24. QUALITY ASSURANCE/INSPECTION**

All goods furnished and services performed pursuant hereto shall be
subject to inspection and test by Buyer at all reasonable times and
places, during the Order term, and in any event, prior to Final
Acceptance as that term is defined in the Statement of Work. No
inspection made prior to Final Acceptance shall relieve Seller from
responsibility for defects or other to meet the failure requirements of
this Order. In the event that goods furnished or services supplied are
not in accordance with the Statement of Work and Schedule or other
requirements. Buyer may require Seller to promptly correct, repair,
replace or re-perform the goods or services. The cost of correction,
repair, replacement, or re-performance shall be determined under Section
7 of this Order. If Seller fails to proceed with reasonable promptness
to perform the required correction, repair, replacement, or
re-performance, Buyer may terminate the Order for default. If Seller is
unable to accomplish the foregoing, then Buyer may procure such
materials and services from another source or perform such services
in-house and charge to Seller's account all costs, expenses and damages
associated therewith. Buyer's approval of designs furnished by Seller
shall not relieve Seller of its obligations hereunder.

**25. ORDER OF PRECEDENCE**

In the event of an inconsistency or conflict between these SAIC Terms
and Conditions and the Order issued, the inconsistency or conflict shall
be resolved by giving precedence in the following order:

1\) The Order including SAIC-Frederick, Inc. Standard Terms and
Conditions, Exhibits thereto and any provisions.

2\) Specifications and/or drawings.

3\) Other documents or exhibits when attached.

**26. TERMINATION**

**Termination for Convenience**

1)  Buyer shall have the right to terminate this Order, in whole or in
    part, at any time, without cause, by providing written notice to
    Seller. Upon receiving notice of such termination, Seller shall:

a\) stop all work on this Order on the date and to the extent specified;

b\) place no further contracts hereunder except as may be necessary for
completing such portions of the Order that have not been terminated; and

> c\) terminate all contracts to the extent that they may relate to
> portions of the Order that have been terminated; and

d\) protect all property in which Buyer has or may acquire an interest
and deliver such property to Buyer.

2)  Within twenty (20) days from such termination, Seller may submit to
    Buyer its written claim for termination charges in the form
    prescribed by Buyer. Failure to submit such claim within such time
    shall constitute a waiver of all claims and a release of all Buyer's
    liability arising out of such termination. Under no circumstances
    shall Seller be entitled to anticipatory or lost profits.

3)  Buyer reserves the right to verify claims hereunder and Seller shall
    make available to Buyer, upon its request, all relevant,
    non-proprietary books and records for inspection and audit (e.g.
    time cards and receipts). If Seller fails to afford Buyer its rights
    hereunder, Seller shall be deemed to have relinquished its claim.

**Termination for Default**

1\) Buyer may, by written notice of default to Seller, terminate the
whole or any part of this Order, in any one of the following
circumstances:

a)  Seller fails to make delivery of the goods or to perform the
    services within time specified herein or any extension thereof; or

b)  Seller fails to perform any of the other provisions of this Order in
    accordance with its terms and does not cure such failure within a
    period of ten (10) days after receipt of notice from Buyer
    specifying such failure; or

c)  Seller becomes insolvent or the subject of proceedings under any law
    relating to the relief of debtors or admits in writing its inability
    to pay its debts as they become due.

2\) If this Order is so terminated, Buyer may procure or otherwise
obtain, upon such terms and in such manner as Buyer may deem
appropriate, goods or services similar to those terminated. Seller shall
be liable to Buyer for any excess costs of such similar supplies or
services.

3\) Seller shall transfer title and deliver to Buyer, in the manner and
to the extent requested in writing by Buyer at or after termination,
such complete or partially completed articles, property, materials,
parts, tools, fixtures, plans, drawings, information and contract rights
as Seller has produced or acquired for the performance of the terminated
part of this Order, and Buyer will pay Seller the contract price for
completed articles delivered to and accepted by Buyer and the fair value
of the other property of Seller so requested and delivered.

4\) Seller shall continue performance of this Order to the extent not
terminated. Buyer shall have no obligation to Seller with respect to the
terminated part of this Order except as herein provided.

**27. SECURITY**

Under its contract with NCI-Frederick, SAIC-Frederick, Inc. may be
required to conduct, on persons performing work on Government Owned or
controlled installations, individual background checks prior to the
commencement of effort. As part of this process, information will be
required to enable SAIC-Frederick, Inc. to conduct the appropriate
background checks, including name (including any aliases), daytime phone
number, SSN, date of birth, and country of birth. Individuals who are
unable or unwilling to provide the required information and/or receive
the required authorizations will not be allowed access to NCI-Frederick
or any controlled premises.

Seller agrees to comply with the Information Technology (IT) systems
security and /or privacy specifications set forth in the Agreement; the
Computer Security Act of 1987; Office of Management and Budget (OMB)
Circular A-130, Appendix III, "Security of Federal Automated Information
Systems", and the DHHS Automated Information Systems Security Program
(AISSP) Handbook, which may be found at the following websites: Computer
Security Act of 1987:
<http://csrc.nist.gov/groups/SMA/ispab/documents/csa_87.txt>, OMB A-130
Appendix III:
<http://www.whitehouse.gov/omb/circulars/a130/a130appendix_iii.html>,
DHHS AISSP Handbook : <http://irm.cit.nih.gov/policy/aissp.html>.

The Seller further agrees to include this provision in any Order awarded
pursuant to the Agreement. Failure to comply with these requirements may
constitute cause for termination under Paragraph 26 of these Terms and
Conditions.

The Seller shall be responsible for properly protecting all information
used, gathered, or developed as a result of the Agreement. The Seller
shall establish and implement appropriate administrative, technical, and
physical safeguards to ensure the security and confidentiality of
sensitive Government information, data and/or equipment. Any Seller
employee who may have access to sensitive information under this
agreement shall complete the form entitled, "Commitment to Protect
Non-Public Information -- Contractor Agreement," which may be found at
the following website:
<http://ais.nci.nih.gov/forms/Non-Disclosure_Form.pdf>.

A copy of each signed and witnessed Non-Disclosure agreement shall be
submitted to the Contracting Officer prior to performing any work under
the Agreement.

The Seller shall assure that each employee has completed the NIH
Computer Security Awareness Training
([http://irtsectraining.nih.gov](http://irtsectraining.nih.gov/)) prior
to performing any work under this contract.

The Seller shall maintain and submit to the Contracting Officer a
listing by name and title of each individual working under this
contract, who has completed the NIH required training. Any additional
security training completed by Seller staff shall be included on this
listing.

In addition, during all activities and operations on Government
premises, the Seller shall comply with DHHS, including National
Institutes of Health (NIH), rules of conduct. Should the Seller have
questions concerning these requirements or need of procedural guidance
to ensure compliance they may contact the cognizant SAIC-Frederick, Inc.
acquisition representative.

**28. TOBACCO USE AT THE NCI-FREDERICK**

In accordance with the Department of Health and Human Services (HHS)
directive, the NCI-Frederick campus is a tobacco free workplace. Use of
tobacco in any form is prohibited on the entire NCI-Frederick campus.
This includes personal vehicles while on NCI-Frederick property and all
government vehicles, regardless of their location.

This policy applies to all employees, Government and Contractor,
visitors, Subcontractors, vendors and guests of the NCI-Frederick, and
extends to all HHS owned or leased facilities and properties external to
the NCI-Frederick campus where the sole tenant(s) are HHS and/or
SAIC-Frederick employees.

**29. PAYMENT AND INVOICING**

Payment -- Work accepted by Buyer shall be paid for in U.S. dollars
(\$USD) within the negotiated terms upon receipt of proper invoice.

30. **STANDARDS OF BUSINESS ETHICS**

Seller, including all lower tiers are expected and required to comply
fully with Buyer's standards of business ethics and conduct and to
inform appropriate Buyer officials immediately of any illegal or
unethical conduct in their dealings with Buyer's officers or employees.
Copies of the Buyer's Code of Ethics and contacts for such reports are
available on [www.saic.com](http://www.saic.com/) at
<http://files.shareholder.com/downloads/SAIC/493002454x0x208224/1fac4a0e-406d-4873-b261-d8bf23d1acd3/ethics_handbook.pdf>.

**31. SEVERABILITY**

If any term contained in this Subcontract is held or finally determined
to be invalid, illegal or unenforceable in any respect, in whole or in
part, such term shall be severed from this Subcontract, and the
remaining terms contained herein shall continue in force and effect, and
shall in no way be affected, prejudiced or disturbed thereby.

**32. INTERPRETATION**

The captions and headings used in this Subcontract are solely for the
convenience of the parties, and shall not be used in the interpretation
of the text of this Subcontract. Each party has read and agreed to the
specific language of this Subcontract; therefore no conflict, ambiguity
or doubtful interpretation shall be construed against the drafter.

**33. ELECTRONIC AND INFORMATION TECHNOLOGY STANDARDS**

Seller agrees to comply with Section 508 of the Rehabilitation Act of
1973 ( 29 U.S.C. 794d ) as amended by P.L. 105-220 under Title IV
(Rehabilitation Act Amendments of 1998). Electronic and Information
Technology (EIT) developed, procured, maintained, and/or used under this
subcontract shall be in compliance with the \"Electronic and Information
Technology Accessibility Standards\" set forth by the Architectural and
Transportation Barriers Compliance Board (also referred to as the
\"Access Board\") in 36 CFR Part 1194. The complete text of Section 508
Final Standards can be Accessed at
<http://www.access-board.gov/sec508/standards.htm>. Applicable standards
to this requirement are set forth in 36 CFR Part 1194.21 through 26.

Seller further agrees to include this provision in any "Order awarded
pursuant to the" Agreement. Failure to comply to "these requirements may
constitute cause for termination under Paragraph 26"of these Terms and
Conditions.

## ATTACHMENT 2 {#attachment-2 .Header-2}

SAIC-FREDERICK INVOICE INSTRUCTIONS

**ATTACHMENT 2**

[SAIC-FREDERICK, INC./NCI INVOICE INSTRUCTIONS FOR FIXED PRICE
SUBCONTRACTS]{.underline}

**General:** The subcontractor shall submit Invoices as prescribed
herein.

**Format:** Invoice Requests may be submitted on the payee\'s
letter-head or self-designed form provided that it contains the
information described herein.

**Number of Copies:** Original and l copy

**Frequency:** Invoices shall be submitted 30-days following the
submittal of associated deliverable as prescribed at ARTICLE B.3.
PRICES/COSTS.

**Preparation and Itemization of the Invoice:** The invoice shall be
prepared in ink or typewritten as follows:

a.  Designated Billing Office and Address

b.  Invoice Number

c.  Date of Invoice

d.  Contract Number and Date

e.  Payee's name and address. Show the contractor's name (as it appears
    in the contract), correct address, and the title and phone number of
    the responsible official to whom payment is to be sent. When an
    approved assignment has been made by the contractor, or a different
    payee has been designated, then insert the name and address of the
    payee instead of the contractor.

f.  Description of goods or services, quantity, unit price (where
    appropriate), and total amount.

g.  Charges for freight or express shipments other than F.O.B.
    destination. (If shipped by freight or express and charges are more
    than \$25, attach prepaid bill)

h.  Equipment. If there is a contract clause authorizing the purchase of
    any item of equipment, regardless of type or value, the purchase
    must be reported with each coinciding invoice accompanied by a
    completed Report of Capitalized Non-Expendable Equipment and
    associated purchase receipts. Note that all equipment purchased with
    funds reimbursed through this subcontract shall remain the property
    of the U.S. Federal Government unless further determination is made
    through the SAIC-F Contracting Officer.

**Currency:** All SAIC/NCI contracts are expressed in United States
(U.S.) dollars. When payments are made in a currency other than U.S.
dollars, billings on the contract shall be expressed, and payment shall
be made, in that other currency at amounts coincident with actual costs
incurred. Currency fluctuations may not be a basis of gain or loss to
the contractor. Notwithstanding the above, the total of all invoices
paid under this contract may not exceed the U.S. dollars authorized.

[]{.mark}

INSTRUCTIONS FOR PREPARATION OF REPORT OF CAPITALIZED NONEXPENDABLE
EQUIPMENT

This

  -----------------------------------------------------------------------
  **Report shall be submitted by the Subcontractor and included with the
  invoice under which reimbursement for the acquisition of authorized
  accountable personal property is requested.**

  1\. Enter date prepared.

  2\. Enter Public Voucher (or invoice) Number

  3\. Enter complete contract number.

  4\. Enter number of this report. (Reports will be numbered serially
  beginning with No. 1 for each subcontract). Enter page number of pages.

  5\. Enter name and telephone number of Subcontractor's representative
  responsible for report.

  6\. Indicate type of report.

  7\. Enter name of responsible party and physical address for which the
  equipment will be located.

  If separate pieces of equipment are purchased and are placed at
  different locations, submit a separate report for each location.

  8\. Leave Blank. For Contracting Agency Use Only.

  9\. Enter Line Item Number. Each Report shall begin with the Number 1.

  10-14. Identify fully the property being reported.

  15\. Enter unit Acquisition Cost of the item.

  16\. This item shall be completed for inventory reporting. For
  Government Owned property, enter identification number.

  17\. Leave Blank

  18\. Enter month and year property was received as reflected on
  receipt.

  19\. Enter signature and title of person authorized to certify the
  accuracy of the report.

  20\. Leave Blank. For Contracting Agency Use Only.
  -----------------------------------------------------------------------

+------------------+-------------------+--------+---------+----+------+
| **REPORT OF      |                   | [1.    | 2\.     |    |      |
| CAPITALIZED      |                   | Date]{ | Public  |    |      |
| NON-EXPENDABLE   |                   | .mark} | Voucher |    |      |
| EQUIPMENT**      |                   |        | No.     |    |      |
+------------------+-------------------+--------+---------+----+------+
|                  |                   | [3.    | 4\.     | Pa | No.  |
|                  |                   | Co     | Report  | ge | of   |
|                  |                   | ntract | No.     | N  | P    |
|                  |                   | No.]{  |         | o. | ages |
|                  |                   | .mark} |         |    |      |
|                  |                   |        |         | 1  | 1    |
+------------------+-------------------+--------+---------+----+------+
| [5. Person       | 6\. Type of       | [7.    |         | 8  |      |
| Res              | Report            | Name   |         | \. |      |
| ponsible]{.mark} |                   | and    |         | SA |      |
|                  |  Acquisition -   | A      |         | IC |      |
| []{.mark}        | Govt. Titled      | ddress |         | U  |      |
|                  |                   | of     |         | se |      |
| [Te              |  Acquisition -   | Contra |         | On |      |
| lephone:]{.mark} | Contractor Titled | ctor]{ |         | ly |      |
|                  |                   | .mark} |         |    |      |
|                  |  Annual          |        |         |    |      |
|                  | Inventory         |        |         |    |      |
|                  |                   |        |         |    |      |
|                  |  Final Inventory |        |         |    |      |
+------------------+-------------------+--------+---------+----+------+

<table style="width:100%;">
<colgroup>
<col style="width: 7%" />
<col style="width: 16%" />
<col style="width: 3%" />
<col style="width: 9%" />
<col style="width: 11%" />
<col style="width: 7%" />
<col style="width: 9%" />
<col style="width: 9%" />
<col style="width: 9%" />
<col style="width: 7%" />
<col style="width: 1%" />
<col style="width: 7%" />
</colgroup>
<tbody>
<tr class="odd">
<td><p><mark></mark></p>
<p><mark>9. Item No.</mark></p></td>
<td colspan="2"><p><mark></mark></p>
<p><mark>10. Description</mark></p></td>
<td><p><mark></mark></p>
<p>11. GFP/CAP</p></td>
<td><p><mark></mark></p>
<p><mark>12. Manufacturer</mark></p></td>
<td><p><mark></mark></p>
<p><mark>13. Model</mark></p></td>
<td><p><mark></mark></p>
<p><mark>14. Serial</mark></p></td>
<td><p><mark></mark></p>
<p><mark>15. Cost</mark></p></td>
<td><p><mark></mark></p>
<p>16. Govt. ID</p></td>
<td colspan="2">17. Acq. Aut.</td>
<td><p><mark></mark></p>
<p><mark>18. Date</mark></p></td>
</tr>
<tr class="even">
<td><mark></mark></td>
<td colspan="2"></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td colspan="2"></td>
<td></td>
</tr>
<tr class="odd">
<td></td>
<td colspan="2"></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td colspan="2"></td>
<td></td>
</tr>
<tr class="even">
<td></td>
<td colspan="2"></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td colspan="2"></td>
<td></td>
</tr>
<tr class="odd">
<td></td>
<td colspan="2"></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td colspan="2"></td>
<td></td>
</tr>
<tr class="even">
<td></td>
<td colspan="2"></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td colspan="2"></td>
<td></td>
</tr>
<tr class="odd">
<td></td>
<td colspan="2"></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td colspan="2"></td>
<td></td>
</tr>
<tr class="even">
<td></td>
<td colspan="2"></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td colspan="2"></td>
<td></td>
</tr>
<tr class="odd">
<td colspan="5"><p><mark>19. Authentication By Contractor=s Supervisory
Accounting Official</mark></p>
<p>Signature: Date:</p></td>
<td colspan="5">20. Accepted by Authorized SAIC-Frederick Inc.
Representative</td>
<td colspan="2">Voucher No.</td>
</tr>
<tr class="even">
<td colspan="2"><mark>Name (Typed)</mark></td>
<td colspan="3">Title</td>
<td colspan="5">Signature &amp; Title</td>
<td colspan="2">Date</td>
</tr>
</tbody>
</table>

## ATTACHMENT 3 {#attachment-3 .Header-2}

SUBCONTRACTING CERTIFICATION

**SUBCONTRACTING CERTIFICATION**

In accordance with the terms of its prime contract under which a
resulting award will be issued, SAIC-Fredrick is committed to maximizing
small business subcontracting opportunities to the maximum extent
practicable. In pursuit of this objective please complete, and include
in your technical proposal, the following certification providing the
percentage of effort that will be conducted by in-house, employee
personnel during the execution of the statement of work as provided
herein (including any option tasks/periods, as applicable):

\*If the percentage of work to be conducted by employees of your
organization is less than 100% a small business subcontracting plan as
described in FAR 19.704 should be provided with your proposal and must
be accepted by SAIC-Frederick prior to subcontract award. Failure to
provide an acceptable subcontracting plan in a timely manner may render
your organization ineligible for subcontract award.

## ATTACHMENT 4 {#attachment-4 .Header-2}

PRICE SCHEDULE AND BASIS OF ESTIMATE

(To be inserted upon award)

## ATTACHMENT 5 {#attachment-5 .Header-2}

SECTION C---RFP STATEMENT OF OBJECTIVES

SECTION C---DESCRIPTION/SPECIFICATIONS/STATEMENT OF OBJECTIVES

ARTICLE C.1. STATEMENT OF OBJECTIVE

###### 

###### 1. BACKGROUND

The National Cancer Institute, a biomedical research funding agency that
is part of the U.S. National Institutes of Health, has invested heavily
in the generation of large scale clinical and molecular data sets. The
NCI through its Center for Biomedical Informatics and Information
Technology (NCI CBIIT) has sponsored the development of the Cancer
Biomedical Informatics Grid^®^ (caBIG^®^) initiative, a common
informatics infrastructure that incorporates and encourages the use of
common data standards, caBIG^®^ is an open source, open access
information network connecting the cancer research community and
enabling the sharing of data and tools. Using the caBIG infrastructure,
researchers can accelerate their ability to share, integrate and analyze
data. By providing a comprehensive collection of interoperable software
tools, data standards, and computing infrastructure, the caBIG
initiative promotes data and knowledge exchange, simplifies
collaboration, and ultimately helps realize the potential of molecular
medicine.

The availability of large scale clinical and molecular data sets and the
presence of a wide range of tools that can be used for their analysis
create important new opportunities for the development and refinement of
biomedical knowledge using *in silico* methods. NCI CBIIT seeks to
develop a group of "*in silico* Research Centers" ("ISRCEs" or
"Centers") with core competencies in bioinformatics. The primary goal of
the ISRCEs will be to add scientific value to the large scale datasets
funded by the NCI and other federal agencies that are accessible through
the caGrid as well as through other sources. This will be accomplished
by applying contemporary methods in biomedical and/or bioinformatics
analysis in order to make discoveries that have the potential to rapidly
advance our understanding of cancer etiology and its effective treatment
and prevention. For purposes of this solicitation, *in silico* research
is any research conducted using computational methods on biomedical
data, which may include computer modeling, novel data aggregation
techniques, data mining, etc.

**2. OBJECTIVES**

The primary objective of this solicitation is to encourage researchers
to generate novel cancer research findings by mining the rich data sets
currently available without access restrictions to the cancer community
and by leveraging caBIG tools and infrastructure as well as the wide
array of data sets and tools available from the broader biomedical
informatics and research communities. Hence, this solicitation is aimed
primarily at bioinformaticians, computational biologists, and
statisticians who are asking key biologic and medical research questions
that can be addressed through data mining, analysis and the integration
of the wide array of disparate datasets.

The scientific goals of the ISRCE will be to:

-   generate publishable novel research findings through integrating,
    analyzing and/or mining the data accessible through caGrid and other
    publicly available data sources;

-   identify novel processes (including workflows) and tools that
    exploit these data resources by supporting the analysis of data
    generated by early phase clinical and basic research studies;

-   develop and make publicly available new data analysis, aggregation
    and mining algorithms capable of working with disparate, potentially
    distributed data resources;

-   encourage availability of additional data resources and analytic
    services that will be useful for biomedical research; and

-   assess the capacity of current publicly available data resources to
    support cancer research through:

    -   discovery of non-obvious relationships

    -   determination of missing key attributes and links that could
        enhance analysis.

Offerors are advised that this solicitation is not issued for the
purpose of generating new experimental data, either of a clinical or a
non-clinical nature, but rather to promote the derivation of novel
research findings from the use of existing experimental (and other)
data.

**3. SCOPE OF WORK**

The ISRCEs will be funded to perform *in silico*, hypothesis-driven
research using data analysis, aggregation and mining focused on
discovery by using caBIG and other publicly available data resources.
Each Center is expected to generate:

-   scientific discoveries reported in white papers, peer-reviewed
    publications and scientific meetings;

-   new methods, analytics, data, and analysis results that are
    developed in the course of performing research and that support
    research outcomes; and

-   gap analyses that address the capacity of publicly available data
    resources, both caGrid-enabled and non-caGrid enabled to support
    basic and clinical cancer research.

The Centers must be structured to be scalable and ultimately engaged in
multiple lines of investigation. It is envisioned that the Centers will
initially contain core *in silico* research teams consisting of a
director, who is a senior professional bioinformatician, computational
biologist, or statistician ("ISRCE Director"), and several junior
professional staff. The ISRCE Director must be established in his or her
field and have documented experience in applying bioinformatics to key
research questions. The core staff must have competency in
bioinformatics, cheminformatics, statistics, and/ or computational
biology as applied to the genomics, proteomics, chemistry, population
sciences, and/or image analysis of cancer and the demonstrated ability
to rapidly master new tools. The ISRCE Director and other members of the
core staff will be expected to contribute and pursue at least one novel,
investigator-initiated line of *in silico* investigation ("research
investigation") as part of the initial funding.

The Center will also be responsible for: providing the deliverables
described below; organizing additional research efforts; participating
in the ISRCE Consortium activities (described below); maintaining a
local caGrid node; and other tasks described in this solicitation.

It is further envisioned that with time (potentially including within
the base period), each ISRCE will develop a portfolio of additional
research investigations. Therefore, a successful Offeror must propose a
vision for an *in silico* research program, of which the first research
investigation is well defined pursuant to Task 4 below. Additional
investigations falling within the scope of the Offeror's research
program may be proposed during the period of performance, so that the
composition of the Center's research portfolio may fluctuate over time.
As new research investigations are undertaken, collaborations between an
ISRCE's core staff and other researchers may take place and are
encouraged.

**4. PROJECT DESCRIPTION**

##  4.1 Overview {#overview .unnumbered}

> The goal of establishing *in silico* Research Centers ("ISRCE") is to
> empower *in silico* research, in which the rich datasets currently
> available to the cancer community are analyzed to produce novel
> discoveries. The ISRCE will perform integrative data analysis using
> heterogeneous and distributed resources to advance the understanding
> of cancer etiology, detection, treatment and prevention. The
> techniques and resources employed are likely to include the whole
> range of tools available to bioinformatics researchers, ranging from
> desktop tools, to scripting languages such as Perl, Python, ruby, to
> statistical analysis packages such as "R" and many others. By
> leveraging caBIG-tools, along with other available resources, a broad
> range of capabilities are enabled in support of *in silico* research.
> Potential studies include, but are not limited to:

-   Deep integrative analyses to identify biomarkers predictive of risk
    in a study population, for example, by mining of TCGA data resources
    (see "Data Resources" below)

-   Investigations of phenotype- genotype correlations through
    analyzing, filtering and integrating imaging, SNP, gene expression,
    proteomic and clinical data for classification

-   Identification of mutation patterns common to diverse types of
    cancer.

> ISRCE shall be led and staffed by *in silico* research teams composed
> of biomedical researchers, bioinformaticians, computational
> biologists, statisticians and other computational scientists with a
> strong research interest in cancer. While collaboration with basic and
> clinical researchers is encouraged, the ISRCE shall be directed by *in
> silico* researchers and the proposed research investigations shall
> have a primarily *in silico* focus.
>
> The objective of the initial and subsequent studies shall be clearly
> defined and the data sets, methods, and analyses used to support these
> objectives must be articulated. ISRCE are encouraged to mine the rich
> data sets currently available (see "NCI-hosted Data Resources" below)
> and integrate their own data sets as appropriate. Integration,
> analysis and interpretation projects shall leverage but are not
> limited to the use of data resources generated with caBIG-compatible
> tools, and infrastructure (see "Research Resources" below). Offerors
> are also encouraged to identify and use data and tools not currently
> maintained as caBIG or other public data resources; these additional
> tools and datasets should be described in the data sharing plans
> accompanying Offerors' technical proposals.
>
> As described below, a research plan for each proposed research
> investigation shall be prepared and approved by the SAIC COTR before
> an ISRCE undertakes a proposed project. Research plans will be
> evaluated by a review panel of subject matter experts.
>
> **4.2 ISRCE Consortium Infrastructure**
>
> To foster *in silico* research and to provide a platform for access,
> communication, collaborative documentation, upload, and distribution
> of data, tools, analyses, and workflows, NCI will provide a supporting
> infrastructure in order to aggregate and simplify access to resources.
> Successful applicants are expected to make use of the provided ISRCE
> wiki, forum, and data repository platforms as a means of
> communicating, documenting, sharing, and distributing analysis tools,
> workflows, results and associated context discussions. The intent is
> to connect research results to the data and the tools used for the
> analysis.
>
> []{.mark}
>
> It is envisioned that the ISRCEs will function as a consortium with
> coordination and oversight by NCI-appointed program staff. ISRCEs will
> be able to share experience and results during regularly scheduled
> teleconferences and through the NCI-provided wiki, forum and data
> repository platforms. Participation in the ISRCE Consortium will allow
> members to:

-   identify opportunities for, and participate in, cross-ISRCE
    integrative data analyses using heterogeneous and distributed
    resources

-   share data and analysis methods with collaborators and members of
    the Consortium

-   help to establish common sets of services, data sources, workflows,
    vocabularies, common data elements and data models to enable the
    further integration of analysis results

> It is hoped that participation in the ISRCE Consortium will encourage
> and facilitate a highly interactive community from which a group of
> mutually supportive *in silico* analysts will emerge. The desired
> outcome is strengthened collaborative ties and new and unexpected
> opportunities for synergistic discovery by Consortium members through
> discussion, annotation and potential incorporation of data, tools, and
> workflows. It is anticipated that algorithms, models and simulations,
> tools, workflows, data, and knowledge derived from ongoing research
> will be made available by individual ISRCEs through their caGrid nodes
> in order to support cross-study comparison and integration.
>
> **4.3 Research Resources**
>
> Offerors are encouraged to use public data resources, including data
> sets generated with caBIG-compatible tools and infrastructure, as well
> as other data and tools subject to their own or third party control
> ("research resources").

## 4.3.1 NCI Hosted Data Resources 

> NCI-hosted data resources available for biomedical informatics
> research by the ISRCEs include:
>
> • Cancer Bioinformatics Infrastructure Objects (caBIO)
>
> (grid-enabled) human and mouse genomic annotations, including
> chromosomes, sequences, SNPs, and pathways
>
> Landing page: <https://cabig.nci.nih.gov/tools/cabio>
>
> Web application: <http://cabioapi.nci.nih.gov/cabio41>
>
> • The Cancer Genome Atlas (TCGA)
>
> clinical, genomic characterization, and sequencing data of brain,
> lung, and ovarian cancers\
> Project web site: <http://cancergenome.nih.gov/>\
> Array-based data from the TCGA program is available in caArray:
> [https://array.nci.nih.gov](https://array.nci.nih.gov/)
>
> • Cancer Genetic Markers of Susceptibility (CGEMS)
>
> (grid-enabled)SNP data for prostate and breast cancers\
> Project web site: [http://cgems.cancer.gov](http://cgems.cancer.gov/)\
> Web application: <https://caintegrator.nci.nih.gov/cgems/>
>
> • Glioma Molecular Diagnostic Initiative (GMDI)
>
> (grid-enabled) gene expression profiles, PCR assays, CGH and SNP
> array, sequencing data, tissue array results and images, proteomic
> profiles, clinical trials data of adult and pediatric human brain
> tumor\
> Web application: <http://caintegrator.nci.nih.gov/rembrandt>
>
> • Director's Challenge Lung Study
>
> (grid-enabled) array-based gene expression data from the Director's
> Challenge Lung Study is available in caArray:
> [https://caarraydb.nci.nih.gov](https://caarraydb.nci.nih.gov/)
>
> • Clinical Proteomic Technologies Assessment for Cancer (CPTAC)
>
> annotated human clinical specimens (normal and cancer)
> <http://proteomics.cancer.gov/>
>
> • Computational Analysis and Portal System (CPAS)
>
> proteomic data from the Mouse Proteomics Technology Initiative
> <http://cpas.nci.nih.gov/>
>
> • Pathway Interaction Database (PID)
>
> highly structured, curated collection of information about known
> biomolecular interactions and key cellular processes assembled into
> pathways\
> <https://cabig.nci.nih.gov/inventory/data-resources/pathway-interaction-database>\
> Web application: [http://pid.nci.nih.gov](http://pid.nci.nih.gov/)
>
> • Cancer Gene Index (silver API)\
> gene-disease and gene-drug relationships mined from Medline abstracts\
> Project website: <http://ncicb.nci.nih.gov/NCICB/projects/cgdcp>\
> Data from the Cancer Gene Index is available in caBIO at
> <http://cabioapi.nci.nih.gov/cabio41>
>
> • Cancer Models Database (caMOD)\
> animal models for human cancer -- genetics descriptions,
> histopathology, images, microarray, therapeutic trials\
> Landing page: <https://cabig.nci.nih.gov/tools/caMOD>\
> Web application:
> [http://cancermodels.nci.nih.gov](http://cancermodels.nci.nih.gov/)
>
> • Tumor Sequencing Project (TSP)\
> microarray-based gene expression, immunohistochemistry, SNP, clinical
> trials data of lung cancer\
> <http://www.genome.gov/19517442>
>
> • Unrestricted caBIG data resources such as federated datasets in
> caArray (microarray repository
> <https://cabig.nci.nih.gov/tools/caArray>) instances, caTissue
> instances (biospecimen management repository
> <https://cabig.nci.nih.gov/tools/catissuesuite>;
> <https://cabig.nci.nih.gov/workspaces/TBPT/biospecimen-data-directory/>)
> and NCIA (National Cancer Imaging Archive
> <https://cabig.nci.nih.gov/tools/NCIA> images and annotations
>
> An inventory of currently available NCI-hosted data resources can be
> found at <https://cabig.nci.nih.gov/inventory>

###  {#section-9 .unnumbered}

### 4.3.2 Other Data and Research Resources {#other-data-and-research-resources .unnumbered}

> Offerors are encouraged to propose other data sets for analysis in
> ISRCE research investigations, including data sets generated by ISRCE
> core staff, current or prospective research collaborators, other
> government agencies, and other publicly available sources. Such other
> data sets shall be entered into the appropriate caBIG repository or
> shall be made available via a caGrid-enabled application in accordance
> with the terms of Offeror's data sharing plan, as described below.
>
> Offerors are also encouraged to apply their own tools to the analysis
> of NCI-hosted or other data resources. These tools should be fully
> described their terms of use by the broader biomedical research
> community specified in the Offerors' data sharing plans. Offerors may
> request funding to share such research resources through the caBIG
> infrastructure and to develop caBIG-compatible application programming
> interfaces ("APIs") for tools and other resources that are not
> currently caBIG-compatible. As ISRCE participants continue to annotate
> and make available new data resources, research tools, analysis
> workflows and results through the ISRCE Consortium infrastructure,
> they will provide the basis for expanded and synergistic research
> opportunities.

Although the development of new analytical tools is not the purpose of
this subcontract, any tools developed incidentally in connection with
ISRCE activities will be subject to the terms of the Offeror's data
sharing plan and other terms of this subcontract.

Commercial, off-the-shelf software may be used in the proposed work. The
use of commercial software shall be noted and justified in the
application. The subsequent purchase or use of commercial products for
the project must be approved by the SAIC-F COTR. If approved and used, a
comprehensive narrative describing the usage of the software shall be
made freely available.

## 4.4 Data Sharing {#data-sharing .unnumbered}

> Offerors must supply data sharing plans as part of their Technical
> Proposals in accordance with Task 3 below that describe the timing and
> the mechanisms by which they will make available both the research
> results, data, tools or other resources developed under this contract
> ("research products") as well as any specified research resources not
> identified below as publicly available.

###  {#section-10 .unnumbered}

###  4.4.1 Research Resources {#research-resources .unnumbered}

> All research resources, including tools and data resources, that are
> used to conduct research under this subcontract shall be made
> available to the Government and the public pursuant to the terms set
> forth in Article H.8.B and in accordance with the Offeror's data
> sharing plan, as amended from time to time pursuant to Task 3 below.
>
> All data resources that are used in research investigations proposed
> by respondents must be generated from ongoing or completed studies
> developed outside the work performed under this contract.

###  {#section-11 .unnumbered}

### 4.4.2 Research Products {#research-products .unnumbered}

> []{.mark}
>
> All research products, as elaborated in Task 6 below, that are
> developed under this subcontract are either Software Deliverables or
> Technical Data Deliverables as defined in Article H.8.A. All research
> products shall be made available to the Government and the public with
> "unlimited rights" as set forth in Article H.8 and in accordance with
> the Offeror's data sharing plan, as amended from time to time pursuant
> to Task 3.
>
> Requirements for data sharing are further discussed below.

**5. TASKS TO BE PERFORMED**

[]{.mark}

**The following represent minimum task requirements. The Offeror should
propose additional tasks as necessary based on their unique research
plan.**

[]{.mark}

1.  ISRCE Management

    1.  ISRCE Project Management Plan

> The Offeror shall develop a Project Management Plan (PMP) describing
> the means to accomplish project objectives. The PMP shall:

-   Include a work breakdown structure (WBS) encompassing planning,
    tracking, execution, and completion activities for all tasks.
    Proposed deliverable due dates may be requested per the deliverable
    schedule in the Milestones and Deliverables/Deliverables Schedule
    section below.

-   Describe the technical approach, organizational resources and
    management controls to be employed to meet the cost, performance,
    and schedule requirements for this effort.

-   Detail the products, methods for producing deliverables, allocation
    of staff and other resources necessary to produce deliverables, and
    timelines.

-   Outline the risk management plan for the project.

> PMP's shall include an MS Project formatted document including the
> WBS, and MS Word documents describing any other plans (e.g. Management
> Approach, Risk). An initial draft of the PMP shall be submitted with
> the Offer. This draft WBS shall encompass any milestone reviews
> described in Section 5 below. Based on review of the PMP, the SAIC-F
> COTR will provide approval to move forward on planned activities. The
> Offeror shall request prior approval for all activities not included
> in the PMP or any modifications to the plan after approval has been
> given. The final PMP, including any approved changes, shall be
> submitted as a deliverable at the end of the project.

1.  Monthly Technical Status Report

> The successful Offeror shall document technical status in detailed
> Monthly Technical Status Reports. All Monthly Technical Status Reports
> will be delivered in the template format provided by the SAIC-F COTR
> during the project kickoff meeting. Monthly Technical Status Reports
> shall be submitted directly to both the SAIC-F COTR and SAIC-F
> Subcontract Specialist. The monthly report will include information
> such as the following; Program status overview, including status of
> deliverables/milestones; Description of activities completed during
> the month; Description of activities planned for the next month;
> Description of resolution(s) to previously-identified
> issues/obstacles; Tasks performed by specific personnel; Delineation
> of risk factors that may delay completion of planned items and
> recommended solution(s).
>
> In addition, the Offeror shall participate in periodic status telecons
> at the direction and period as specified by the SAIC-F COTR. Periodic
> telecons shall be held at a period of weekly or greater frequency, but
> focused status telecons to address specific issues may also be
> requested.
>
> **Deliverable: Monthly Technical Status Reports**

2.  Final Project Summary Report

> The successful Offeror shall submit a Final Project Summary Report at
> the conclusion of the project. This report shall describe the work
> accomplished, draft publishable manuscripts, issues encountered and
> resolutions to them; as well as proposals for future research efforts,
> gap analysis of data sources and tools used, and lessons learned. The
> final version of the project summary report, including any approved
> changes made during review, shall be delivered to the SAIC-F COTR in
> electronic form (Microsoft Word™ format) at the completion of the
> project.

Deliverable: Final Project Summary Report

2.  Participate in ISRCE Consortium Activities

To foster *in silico* research and to provide a platform for access,
communication, and collaboration a supporting infrastructure will be
provided by the NCI. The successful Offeror is expected to make use of
the provided ISRCE wiki, forum, and any common provided data repository
platforms as a means of communicating, documenting, and sharing
knowledge gained from the ISRCE research. ISRCE participants shall
attend and actively participate in regularly scheduled teleconferences
and Consortium meetings. The meetings will be primarily scientific in
nature during which the work of the participants shall be discussed and
reviewed. For the purpose of budgeting, ISRCE shall plan on preparation
for and travel to two caBIG-sponsored meetings per year at which ISRCE
activities and results will be presented and discussed.

3.  Develop Data Sharing Plan

    Each Offeror shall submit as part of its Technical Proposal a draft
    data sharing plan specifying the research resources and research
    products to be shared that describes the timing and mechanisms by
    which the Offeror will make available both any research resources
    that are not publicly available as well as any resulting research
    products. As described in the Section M -- Evaluation Factors for
    Award, adequacy of the draft data sharing plan will be considered
    when proposals are scored. Successful Offerors will have their data
    sharing plan reviewed by the SAIC-F COTR, NCI PO and the caBIG Data
    Sharing and Intellectual Capital (DSIC) Workspace Facilitator;
    comments shall be incorporated and the final data sharing plan
    provided within 90 days of subcontract award date. The final data
    sharing plan, as may be revised during the negotiation process
    between the Offeror and the SAIC-F COTR, shall become a term and
    condition of the awarded subcontract. The final data sharing plan
    will be further revised from time to time as needed in order to
    reflect research resources and research products associated with
    subsequent research investigations, as contemplated in Tasks 4, 5,
    and 6.

    []{.mark}

All research resources that are used in research investigations proposed
by Offerors must be generated from ongoing or completed studies
developed outside the work performed under this contract. All research
resources and research products shall be made available to the
Government and the public pursuant to the terms set forth in Article
H.8.B and in accordance with the terms of the Offeror's data sharing
plan.

The data sharing plan shall detail the specific government and public
rights of each research product to be made available. The Government
must have the maximum rights to distribute the research findings,
analysis results and other data produced under this subcontract subject
to the limitations of federal laws and regulations concerning privacy
and the conduct of research, including human subjects research
protections. Any data resources that are subject to restricted access
conditions are considered "Proprietary Technical Data" under Article
H.8.A and must be explicitly described. Offerors that plan to use
proprietary data resources must obtain prior written permission from the
SAIC-F Contracting Officer unless the Offeror can provide written
assurance that any research findings, analysis results or other data
derived from the use of such proprietary data resources can be
disseminated without restriction (except for privacy, human subjects
protection or other regulatory reasons). The data sharing plan must also
provide that if the Offeror and/or its collaborators file patent
applications on any research products delivered under the subcontract,
they agree that they will permit any research products covered by patent
applications or issued patents to be used for research or educational
purposes by the public without charge under terms that are consistent
with the National Institutes of Health (NIH) Principles for Recipients
of NIH Research Grants and Contracts on Obtaining and Disseminating
Biomedical Research Resources, 64 Fed. Reg. 72090 (Dec. 23, 1999).

[]{.mark}

Any research findings, analysis tools, results, and/or other data
generated through the conduct of the research under this subcontract may
be made available through a caBIG-compliant interface and include a
description of the scientific study represented, the number of samples
in the study (if applicable), and other relevant information. The
Offeror shall also include a plan for maintaining such datasets.

In addition, the Offeror's data sharing plan shall specify:

-   the terms of use, including any restrictions on access or
    distribution, by the broader biomedical research community of any
    research resources proposed for use, and if applicable, when such
    resources will be publicly available without restrictions on use

-   when research products, including data sets and any tools developed
    in the course of conducting research, will be publicly available
    without restrictions on use

-   whether data sets and tools (either research resources or research
    products) will be entered into the appropriate caBIG repository or
    made available via a caGrid-enabled application.

In preparing their data sharing plans, Offerors shall use the caBIG Data
Sharing and Security Framework (DSSF) to assess the sensitivity of
proposed research resources and any expected research products and then
describe any access conditions, including any requirements for data use
agreements. For more information on the DSSF, please refer to the Data
Sharing and Security Framework (DSSF) Web-cast Materials (available at:
[**https://cabig.nci.nih.gov/working_groups/DSIC_SLWG/DSSF_Webcast**](https://cabig.nci.nih.gov/working_groups/DSIC_SLWG/DSSF_Webcast)).

The Offeror is responsible for obtaining all permissions or approvals
required to provide access or distribute any nonpublic research
resources in order to comply with the undertakings of the data sharing
plan. The Offeror must:

-   provide documentary support for such permission from research
    collaborators not affiliated with the proposed ISRCE, regardless of
    whether such collaborators are affiliated with the institution(s) at
    which the ISRCE is located; and

-   specify the steps and dates for any required approvals to share
    research resources or research products from IRBs or any other
    institutional bodies, and supply documentation of such approvals
    within 180 days of the contract award date.

For purposes of obtaining such approvals, the Offeror may wish to
consult the caBIG Guidelines for Preparing Data Sharing Plans
established by NCI-CBIIT through the caBIG Data Sharing and Intellectual
Capital (DSIC) Workspace. The Guidelines are available on-line at

[**https://cabig.nci.nih.gov/working_groups/DSIC_SLWG/Documents/caBIG_Data_Sharing_Plan_Guideline_20080109.pdf**](https://cabig.nci.nih.gov/working_groups/DSIC_SLWG/Documents/caBIG_Data_Sharing_Plan_Guideline_20080109.pdf).
For more information regarding preparation of data and research
resources sharing plans, the offeror may also present questions through
the DSIC Knowledge Center WIKI
([**https://cabig-kc.nci.nih.gov/DSIC/KC**](https://cabig-kc.nci.nih.gov/DSIC/KC)).

As new research investigations are proposed and accepted, the offeror
shall amend the data sharing plan and obtain any necessary approvals
within timeframes described above.

4.  Develop Research Plans

The Offeror shall prepare a research plan for each project planned for
the base period of the award that is consistent with the quality of
research plans submitted with NIH grant applications. The research plan
shall detail the specific hypothesis and goals of the research, as well
as expected outcomes. The plan shall detail the significance of the
proposed research and the anticipated impact on the knowledge of cancer
mechanisms or outcomes.

The research design shall be presented, including the caBIG and other
data sources and tools to be used to conduct the research. Expected data
mining and other methodologies shall be detailed.

Each research plan shall also describe the anticipated research
products. Anticipated products include but are not limited to the
following;

-   Algorithms

-   Models and Simulations

-   Tools

-   New Workflows and Processes

-   Data

-   Research Findings/ Analysis Results and New Knowledge gained from
    this Research

The research plan must describe, in accordance with the initial data
sharing plan, the specific way in which each research product generated
pursuant to Task 6) will be made publicly available and the ISRCE's data
sharing plan should be updated accordingly. Research products that lend
themselves to caGrid enablement should be disseminated via the caGrid
infrastructure.

The Offeror should expect to propose additional lines of research during
the performance of the subcontract. A research plan for each proposed
research investigation shall be prepared and approved by the SAIC COTR
before an ISRCE undertakes the project.

5.  Conduct Research

The ISRCE team shall conduct research that is described in the approved
project research plans. All risks identified in the Management Plan and
individual Research Plans (e.g. inability to access a planned data
resource) shall be monitored and any that reach a critical level shall
be brought immediately to the attention of the SAIC-F COTR.

Research teams shall consist of biomedical/bioinformatics researchers
but may be assisted by IT personnel if needed in order to help implement
any needed IT infrastructure such as grid nodes and distributed data
access.

Collaborations with researchers outside of the ISRCE institution, with
other ISRCEs, and at NCI-funded Cancer Centers are encouraged.

6.  Develop Research Report and Products

In the course of conducting such research, it is anticipated that new
research products such as algorithms, clients for accessing data and
services, processes, and other artifacts will be developed. A goal of
this solicitation is to make these research products available to the
general bioinformatics and cancer research communities. A wide variety
of research products may be developed, including but not limited to:

-   [Algorithms]{.underline}. In the course of either data mining or
    hypothesis-driven *in silico* research, algorithms for discovering
    previously unknown relationships in data resources may be developed.
    In these cases, the specific algorithm(s) that was used should be
    documented and the relevant documentation and accompanying source
    code made available by posting to the appropriate forum as described
    in the research and data sharing plans and approved by the SAIC-F
    COTR. When relevant, such algorithms can be made available as caGrid
    analytical services.

-   [Models and Simulations]{.underline}. Models and simulations
    developed to support research should be documented, both in terms of
    the model or simulation fidelity and content, and in terms of their
    use or potential for reuse. Simulation or model source code
    developed in the course of research should be posted to the
    appropriate forum as described in the research and data sharing
    plans and approved by the SAIC-F COTR. Simulations and models may
    also be made available as caGrid analytical services.

-   [Tools]{.underline}. Examples of tools include portals, user
    interfaces, clients, data aggregation and distributed data access
    routines, and any general purpose software developed in the course
    of performing *in silico* research that would be of general benefit
    to the cancer bioinformatics research community. Any tools developed
    as research products need to include high level user guides and
    shall be made available, at a minimum, as a reference implementation
    posted to the appropriate forum as described in the research and
    data sharing plans and approved by the SAIC-F COTR. .

-   [Workflows and Processes]{.underline}. In order to perform the
    proposed research, novel processes may be developed that require
    coordinated sequencing of data access and service of function
    invocations. If these workflows are deemed to be reusable by the
    general bioinformatics community, they should be documented and
    posted to the appropriate forum as described in the research and
    data sharing plans and approved by the SAIC-F COTR. If applicable,
    it is preferred that Taverna or Gene Pattern workflows be
    constructed consistent with caBIG standards. Workflows should be
    deposited to appropriate web resources; deposition with the
    myExperiment project
    ([http://www.myexperiment.org](http://www.myexperiment.org/)) is
    encouraged.

-   [Research Findings, Analysis Results and Other Research
    Data]{.underline}. All research data generated by ISRCEs in the
    course of performing *in silico* research should be made publicly
    available, consistent with the Offeror's data sharing plan, through
    peer-reviewed publications as well as through posting to the
    appropriate forum as described in the research and data sharing
    plans and approved by the SAIC-F COTR.

**6. MILESTONES AND DELIVERABLES**

[]{.mark}

## Milestone Reviews

> In fulfillment of this project, the successful Offeror shall prepare
> for and attend the following meetings and milestone reviews. Location,
> procedures, and presentation formats will be determined by the SAIC-F
> COTR.

### 6.1.1 Project Kickoff {#project-kickoff .unnumbered}

> An initial kick off meeting will be held within 7 calendar days of
> award or as agreed to by the SAIC-F COTR. This will be attended by the
> SAIC-F COTR, SAIC-F Subcontract Specialist, and the NCI Project
> Officer. Proposed Key Personnel as well as a contract's representative
> from the successful Offeror's organization are required to attend. The
> intent of the kickoff is for all key personnel to meet to discuss the
> project's overall technical and contractual requirements.
>
> At this meeting, the successful Offeror shall be prepared to discuss
> the following;

-   Technical Objectives

-   Preliminary Management and Research Plans

-   Discussion of Research Products

-   Deliverables and Deliverable Acceptance Criteria

-   caBIG Compliance and Data Sharing Plan

-   Reporting and Invoice Requirements

> This meeting may also be attended by a caBIG Mentor, so that
> requirements with respect to specific caBIG compliance criteria can be
> discussed. Any proposed changes to specific compliance or deliverable
> acceptance criteria must be provided in writing within 7 days and
> agreed to by the SAIC-F COTR.

###  {#section-12 .unnumbered}

### 6.1.2 Research Review  {#research-review .unnumbered}

> Approximately ¼ of the way through the project period of performance
> there shall be a planned review of research progress. At this review
> the successful Offeror will present but not be limited to the
> following:

-   Updated Management and Research Plans

-   Updated Data Sharing Plan

```{=html}
<!-- -->
```
-   Planned Research Products

###  {#section-13 .unnumbered}

### 6.1.3 Deliverables Readiness Review  {#deliverables-readiness-review .unnumbered}

> There shall be a deliverables readiness review approximately ¾ through
> the period of performance. This review will be an opportunity for
> SAIC-F to determine progress against all tasks. At this review the
> successful Offeror is expected to review current status of all
> deliverables.

  -----------------------------------------------------------------------
  MILESTONE                     DUE DATE
  ----------------------------- -----------------------------------------
  Project Kickoff               7 Days after Authority to Proceed

  Research Review               Approximately 1/4 Through Project,
                                successful Offeror supplied date with PMP

  Deliverables Readiness Review Approximately 3/4 Through Project,
                                successful Offeror supplied date with PMP
  -----------------------------------------------------------------------

## 6.2 Baseline Milestones/Deliverables {#baseline-milestonesdeliverables .unnumbered}

### 6.2.1 Baseline Milestones/Deliverable List and Due Dates {#baseline-milestonesdeliverable-list-and-due-dates .unnumbered}

> The following table contains a list of baseline deliverables with
> notation of due dates which represent minimum deliverables and task
> requirements. The Offeror should propose additional Milestones with
> associated tasks and deliverables as necessary based on their unique
> research plan. The final subcontract will include the baseline as well
> any those additional proposed by the offeror and accepted by SAIC-F.
>
> All days identified are intended to be normal business days unless
> otherwise specified. The successful Offeror may suggest an alternative
> due date for any or all deliverables in their offer. The final
> schedule will be agreed to by the SAIC-F COTR and the successful
> Offeror, based on the successful Offeror's proposed cost and proposed
> delivery schedule.

  -----------------------------------------------------------------------
  MILESTONE/DELIVERABLE         DUE DATE
  ----------------------------- -----------------------------------------
  ISCRE Management Plan         No later than 30 days after Subcontract
                                Award

  Monthly Status Reports        10^th^ of each month

  Data Sharing Plan             No later than 90 days after Subcontract
                                Award

  Research Plan                 No later than 90 days after Subcontract
                                Award

  Research Report               Within 30 days of the completion of first
                                research project

  Research Products             Within 30 days of completion of first
                                research project

  Final Project Report          Subcontract Expiration
  -----------------------------------------------------------------------

> Acceptance criteria for each of these deliverables are given below.

###  {#section-14 .unnumbered}

### 6.2.2 Format and Delivery {#format-and-delivery .unnumbered}

> Monthly Reports and any documents containing sensitive information
> such as financials shall be sent via email directly to both the SAIC-F
> COTR and SAIC-F Subcontracts Specialist. These reports shall be sent
> in the format as specified by the SAIC-F COTR.
>
> Documentation deliverables other than those described above shall be
> in MS Office Format and placed on the GForge project page associated
> with the project. The SAIC-F COTR will provide direction regarding the
> specific GForge location. The successful Offeror shall submit all
> software deliverables in electronic media to the GForge project page
> associated with the project as specified by the SAIC-F COTR. A
> notification of upload or subsequent updates to deliverables on GForge
> shall be forwarded via email to both the SAIC-F COTR and the SAIC-F
> Subcontract Specialist.

### 6.2.3 Baseline Deliverable Acceptance Criteria {#baseline-deliverable-acceptance-criteria .unnumbered}

> [Specific Acceptance Criteria]{.underline}
>
> The following general criteria represent a baseline for the
> evaluations of deliverables listed above. **Final Deliverable
> Acceptance Criteria will be established upon award and will be based
> on each successful Offeror's proposed plans.**
>
> **.**
>
> **Deliverable:** ISRCE Project Management Plan
>
> **Acceptance Criteria:** The ISRCE Project Management Plan shall
> include the following;

-   Project Schedule; The Project schedule shall be delivered in MS
    Project format. It shall include a hierarchical set of tasks
    representing the Work Breakdown Structure (WBS) required for the
    successful Offeror to successfully complete the tasks given in this
    statement of objectives. Task dependencies, task dates, resource
    loading, and updated milestones and deliverable dates shall all be
    included.

-   Management Approach; The Management Approach shall be an MS Word
    formatted document that describes the organizational resources and
    management controls employed to meet the cost, performance, and
    schedule requirements as outlined in the project schedule. This
    shall detail the products, methods for producing deliverables
    including research products, allocation of staff and other resources
    necessary to produce deliverables, and timelines, and any expected
    Government Furnished Information/Equipment expected from the
    Government (GFE). A risk management plan shall be included that
    outlines project risks, potential severity of those risks, and
    mitigation strategies for those risks.

> Acceptable Project Management Plans will include the above
> information, in the formats requested, in sufficient detail to cover
> all tasks requested in this RFP.
>
> **Deliverable:** Monthly Technical Status Report
>
> **Acceptance Criteria:** The monthly technical status report shall be
> delivered in the template supplied by the SAIC-F COTR with all fields
> completed. Any exceptions must be approved by the SAIC-F COTR. It
> shall be sent via email directly to the SAIC-COTR and SAIC-F
> Subcontract Specialist. Acceptable monthly technical status reports
> will contain the complete set of requested information in the format
> requested
>
> **Deliverable:** Data Sharing Plan
>
> **Acceptance Criteria:** The data sharing plan shall detail the
> specific government and public rights of each research product to be
> made available in this project. The Government must have the maximum
> rights to distribute the data produced during the project subject to
> the limitations of federal laws and regulations concerning privacy and
> the conduct of research, including human subjects research
> protections. Any data resources that are subject to restricted access
> conditions are considered "Proprietary Technical Data" under Article
> H.8.A of this subcontract and must be explicitly described. Offerors
> that plan to use proprietary data resources must obtain prior written
> permission from the SAIC-F Contracting Officer unless the Offeror can
> provide written assurance that any research findings, analysis results
> or other data derived from the use of such proprietary data resources
> can be disseminated without restrictions (except for privacy, human
> subjects protection or other regulatory reasons). The data sharing
> plan must also provide that if the offeror and/or its collaborators
> file patent applications on any research products delivered under the
> contract, they agree that they will permit any research products
> covered by patent applications or issued patents to be used for
> research or educational purposes by the public without charge under
> terms that are consistent with the National Institutes of Health (NIH)
> Principles for Recipients of NIH Research Grants and Contracts on
> Obtaining and Disseminating Biomedical Research Resources, 64 Fed.
> Reg. 72090 (Dec. 23, 1999).
>
> Although the final data sharing plan is a formal deliverable, the
> Offeror must submit the draft data sharing plan as part of the
> response to the solicitation. Significant deviations from the draft
> data sharing plan provided with the technical proposal will prevent
> the acceptance of this deliverable and will prevent acceptance of
> further deliverables.
>
> **Deliverable:** Research Plan
>
> **Acceptance Criteria:** Each research plan shall include at a minimum
> the following information:

-   significance of the proposed research

-   specific hypothesis and goals of the research

-   expected outcomes

-   research design and methodologies

-   anticipated products of the research and the methods by which they
    will be made available to the cancer bioinformatics community, which
    shall be included in the Offeror's updated data sharing plan

> Research plans will be evaluated by a scientific and technical
> evaluation panel of subject matter experts. Acceptance will be judged
> against the scientific merit of the plan as outlined in this
> solicitation along with the completeness of the plan and its potential
> to accomplish the ISRCE goals also as outlined in this solicitation.
> The review methodology and criteria will be modeled after that
> described for NIH grant applications
> (<http://grants1.nih.gov/grants/peer/>). Acceptance of the research
> plan will also be based on an adequate representation of the planned
> research products.
>
> **Deliverable:** Research Report
>
> **Acceptance Criteria:** Research reports shall describe the research
> in a manner that will be acceptable to other bioinformaticians
> performing similar research and meet the quality of manuscripts
> submitted for publication. The research report(s) will be submitted to
> a scientific and technical evaluation panel and the acceptability of
> the report judged against the following criteria:

-   The performed research adheres to the approved research plan

-   The scientific conclusions cited in the report are valid based on
    the supplied data and information

-   The report contains a comprehensive bibliography adequately
    describing the current state of knowledge relevant to the topic
    covered by the research

-   The report is clearly written and all graphics are of publication
    quality

-   The report adheres to a manuscript style to be determined by the
    SAIC-F COTR developed in consultation with the Offeror and the
    program staff

> Manuscripts planned to be submitted for publication will also be
> accepted for review.
>
> **Deliverable:** Research Products
>
> **Acceptance Criteria:** Research Products must be made available as
> described in the Offeror's data sharing plan. Each research product
> shall be accompanied by documentation explaining the product, its
> function, its intended use, and how it is to be accessed and operated
> or employed by an end-user. This documentation shall be consistent
> with the product descriptions in the Research Plan. Product
> documentation will be accepted if it contains this information in
> sufficient detail for a bioinformatician with experience comparable to
> the intended end user to be able to devise a test and user acceptance
> plan using this information. Acceptance for all products will be
> contingent on acceptance of product documentation as described here,
> the posting of that product to its publicly available web resource as
> described in the research and data sharing plans, and successful
> functional and user testing of the function and features described in
> the product documentation.
>
> **Deliverable:** Final Project Report
>
> **Acceptance Criteria:** The Final Project Report shall be delivered
> in Microsoft Word format and shall describe the work accomplished
> against each task in this Statement of Work and its success in meeting
> the goals and objectives of this solicitation as described above. All
> research products developed through this work shall be described. Any
> issues encountered, resolutions, and gaps discovered and lessons
> learned shall also be given. The report shall include a sustainment
> plan for any deployed caGrid services, either analytical or data
> services.

### 6.2.4. Deliverable Review and Acceptance Process {#deliverable-review-and-acceptance-process .unnumbered}

> For all deliverables, the SAIC-F COTR will perform an evaluation for
> each deliverable using acceptance criteria provided above.
> Approval/rejection notice will be sent to the successful Offeror
> within 30 calendar days of receipt of the deliverable. If deliverables
> meet the acceptance criteria, the SAIC-F Contracting Officer will
> issue the successful Offeror a written acceptance through email that
> acknowledges both receipt and overall acceptance of the deliverable.
> Irrespective of payment status for subject deliverable, successful
> Offeror shall not assume acceptance has been made without formal
> notification from the SAIC-F Contracting Officer. If deliverables do
> not meet the acceptance criteria, all issues will be described
> unambiguously and sent to the successful Offeror via email. The
> successful Offeror will then address each issue or state why the issue
> may not be addressed and resubmit the deliverable. Resubmitted
> deliverables will be reviewed within 15 calendar days.
>
> Absence of any comments by the SAIC-F Contracting Officer will not
> relieve the successful Offeror of the responsibility for complying
> with requirements in this statement of work. Final approval and
> acceptance of documentation required herein shall be by letter of
> approval from the SAIC-F Contracting Officer. The successful Offeror
> shall not construe any letter of acknowledgment of receipt of
> deliverable as a waiver of review or as an acknowledgment that the
> deliverable is in conformance with the overall requirement.

[]{.mark}

[]{.mark}

## 6.3 Milestone and Payment Schedule {#milestone-and-payment-schedule .Header-2}

##  {#section-15 .Header-2}

## The following schedule is provided for informational purposes only and will be updated to include any additional milestones proposed by the offeror, including their corresponding price and. Once accepted, this schedule will be made part of the resulting Subcontract as Attachment 4. Offeror should add or insert rows as necessary based on their specific Research Plan. Milestones listed below are minimum requirements and may NOT be removed. One milestone and payment schedule should be submitted for each potential subcontract period (i.e. base period, option period one and option period two). {#the-following-schedule-is-provided-for-informational-purposes-only-and-will-be-updated-to-include-any-additional-milestones-proposed-by-the-offeror-including-their-corresponding-price-and.-once-accepted-this-schedule-will-be-made-part-of-the-resulting-subcontract-as-attachment-4.-offeror-should-add-or-insert-rows-as-necessary-based-on-their-specific-research-plan.-milestones-listed-below-are-minimum-requirements-and-may-not-be-removed.-one-milestone-and-payment-schedule-should-be-submitted-for-each-potential-subcontract-period-i.e.-base-period-option-period-one-and-option-period-two. .Header-2}

##  {#section-16 .Header-2}

  ------------------------------------------------------------------------
  MILESTONE                  DUE DATE                        Price
  -------------------------- ------------------------------- -------------
  ISCRE Management Plan      No later than 30 days after     
                             Subcontract Award               

  Data Sharing Plan          No later than 90 days after     
                             Subcontract Award               

  Research Plan              No later than 90 days after     
                             Subcontract Award               

  Research Report            Within 30 days of the           
                             completion of first research    
                             project                         

  Research Products          Within 30 days of completion of 
                             first research project          

  Final Project Report       Subcontract Expiration          
  ------------------------------------------------------------------------

## ATTACHMENT 6 {#attachment-6 .Header-2}

SUBCONTRACTOR'S PROPOSED STATEMENT OF WORK

(To be included at time of award)