Wan-hsun Carolyn Wu, Ph.D.

Laboratory of Functional and Molecular Imaging

National Institute of Neurological Disorders and Stroke

National Institutes of Health

10 Center Drive, MSC 1065

Bethesda, MD 20892-1065

Tel: (301) 451-9913

Fax: (301) 435-8228

E-mail: wuwh@ninds.nih.gov

**[Education]{.underline}**

1993-1999 Ph.D., Psychology Department, Vanderbilt University,
Nashville, TN.

1991 B.S., Psychology Department, National Taiwan University, Taipei,
Taiwan.

**[Research/Professional Experience]{.underline}**

2004-present Research Fellow (Advisor: Alan Koretsky)

National Institutes of Health, National Institute of Neurological
Disorders and Stroke, Laboratory of Functional and Molecular Imaging,
Bethesda, MD.

2004. Postdoctoral Fellow (Advisor: Leonardo Cohen)

National Institutes of Health, National Institute of Neurological
Disorders and Stroke,

Human Cortical Physiology Section, Bethesda, MD.

1998-1999 Research Assistant (Advisor: Jon H. Kaas)

Psychology Department, Vanderbilt University, Nashville, TN.

1994-1997 Teaching Assistant

Psychology Department, Vanderbilt University, Nashville, TN.

1993 Research Assistant (Advisor: Jon H. Kaas)

Psychology Department, Vanderbilt University, Nashville, TN.

1993. Research Assistant (Advisor: C.S. Tung)

Department of Biophysics, National Defense Medical Center, Taipei,
Taiwan.

1991. Part-time Research Assistant (Advisor: K.C. Liang)

Department of Psychology, National Taiwan University, Taipei, Taiwan.

**[Academic Honors and Awards]{.underline}**

2004 Fellow Award for Research Excellence - National Institutes of
Health, Bethesda, MD.

2003 Special Act or Service Award -- National Institute of Neurological
Disorders and Stroke, Bethesda, MD.

2003 Fellow Award for Research Excellence - National Institutes of
Health, Bethesda, MD.

1999-2004 Intramural Research Training Award - National Institutes of
Health, Bethesda, MD.

1999 Travel Award - Society for the Neural Control Movement Symposium,
Kauai, Hawaii.

1999 Travel Award - Graduate School of Vanderbilt University.

1996 Travel Award - 20th Symposium of the Center for Visual Science,

University of Rochester, Rochester, NY.

1994 Travel Award - 18th Symposium of the Center for Visual Science,

University of Rochester, Rochester, NY.

1991-1993 Training Award - S.C. Wang Foundation at the National Defense
Medical Center, Taipei, Taiwan.

1990 Student Fellowship Award - National Science Council of Taiwan,
Taipei, Taiwan.

**[Referee for Scientific Journals]{.underline}**

Experimental Brain Research

**[Scientific Societies]{.underline}**

Member, Society for Neuroscience

Member, Society for International Brain Research Organization

**[Publications-Peer Reviewed Papers]{.underline}**

**Wu WH**, Hwang NG, Yin TH, Tung CS (1993). Effect of prefrontal
cooling on levels of glutamate, DOPAC, and 5-HIAA in nucleus accumbens
and striatum *in vivo*. *The Chinese Journal of Physiology* 36:1-6.

Tung CS. **Wu WH**, Tseng CJ, Yin TH (1994). Effect of amperozide on
schedule-induced polydipsia in rats. *European Journal of Pharmacology*
256:193-200.

**Wu WH**, Hwang NK, Tseng CJ, Yin TH, Tung CS (1995). Evidence that
5-HT(2) antagonism elicits a 5-HT(3)-Mediated increase in dopamine
transmission. *Journal of Biomedical Science* 2:174-182.

**Wu CWH**, Florence SL, Tigges MH, Kaas JH (1998). Morphology of M-cell
axon arbors in striate cortex of monkeys reared with monocular aphakia.
*Developmental Brain Research* 108:47-57.

**Wu CWH**, Kaas JH. (1999). Reorganization in primary motor cortex of
primates with long-standing therapeutic amputations. *Journal of
Neuroscience* 19:7679-7697.

**Wu CWH**, Bichot NP, Kaas JH (2000). Converging evidence from
microstimulation, cytoarchitecture and connectivity for multiple motor
areas in frontal and cingulate cortex in prosimian galagos. *Journal of
Comparative Neurology* 423:140-177.

**Wu CWH**, Kaas JH (2000). Spinal cord atrophy and reorganization of
motoneuron connections following long-standing limb loss in primates.
*Neuron* 28: 967-978.

**Wu CWH**, Kaas JH (2002). The effects of long-standing limb amputation
on anatomical organization of the somatosensory brainstem and spinal
cord. *Somatosensory and Motor Research* 19: 153-163.

**Wu CWH**, Kaas JH (2003). Somatosensory Cortex of Prosimian Galagos:
Physiological recording, Cytoarchitecture and Corticocortical
Connections in Anterior Parietal Cortex and the Vicinity of the Lateral
Sulcus. *Journal of Comparative Neurology* 457: 263-292.

Floel A., Peoppel D, Buffalo E, Braun A, **Wu CWH**, Seo HJ, Stefan K,
Knecht S, Cohen LG (2004). Prefrontal cortex asymmetry for memory
encoding of words and abstract shapes. *Cerebral Cortex* 14: 404-409.

Pietrini P, Furey ML, Ricciardi E, Gobbini MI, **Wu WHC**, Cohen L,
Guazzelli M, Haxby JV (2004). Beyond Sensory Images: Object-Based
Representation in the Human Ventral pathway. *PANS* 101: 5658-5663.

Boroojerdi B, Rothman D, Ognen P, Mason G, Appel M, **Wu CWH**, Sawaki
L, Cohen LG. Rapid activity-dependent changes in GABA in the human
visual cortex. Under revision for *Journal of Neuroscience*.

van Gelderen P, **Wu CWH**, de Zwart J, Hallett M, Cohen LG, Duyn J.
Functional resolution and reproducibility of BOLD and perfusion MRI at
3.0 Tesla. Submitted to *Magnetic Resonance Imaging*.

**Wu CWH**, van Gelderan P, Hanakawa T, Yaseen Z, Cohen LG. Enduring
Representational Plasticity after Somatosensory Stimulation. Submitted
to *Journal of Nuuroscience*.

**Wu CWH**, Seo HJ, Cohen LG. Effect of peripheral soomatosensory nerve
stimulation on improvement of skillful hand functions of chronic stroke.
(in preparation).

Sawaki, L , Werhann K., **Wu CWH**., Cohen LG (2004) Effect of nerve
stimulation in motor learning of use-dependent plasticity in stroke
patients (in preparation).

**Wu CWH**, Werhan KJ, Katya S, Seo HJ, Floel A, Cohen LG. Neural
substrate for the enhanced tactile spatial acuity (TSA) during acute
hand deafferentation. (in preparation).

# [Publication-Abstracts]{.underline}

Ching CP, **Wu WH**, Lu CC, Tung CS (1991). The effect of locus
coeruleus and excitatory amino acid pathways on morphine dependent and
withdrawal on schedule-induced polydipsia. *Eighteenth Annual Conference
of Medical Science*, Taipei, Taiwan.

Tung CS, Lu CC, Liu YP, **Wu WH**, Yin TH (1992). The role of central
mono-aminergic system in adjunctive drinking (AD) control. *Seventh
Annual Conference of Biomedical Science*, Taipei, Taiwan.

**Wu WH**, Liu YP, Tung CS (1992). *In Vivo* measurement of
dihydroxyphenylacetic acid by intracerebral dialysis: change after
amperozide. *Seventh Annual Conference of Biomedical* Science, Taipei,
Taiwan.

Liu YP, Tseng CJ, **Wu WH**, Tung CS (1992). Microdialysis studies on
the 5-HT2 analogue actions on midbrain DA neurons. *Seventh Annual
Conference of Biomedical Science*, Taipei, Taiwan.

**Wu WH**, Liu YP, Tung CS (1992). The effect of potential antipsychotic
drug, Amperozide on the schedule-induced polydipsia. *Nineteenth Annual
Conference of Medical Science*, Taipei, Taiwan.

Yin TH, **Wu WH**, Tseng CJ, Tung CS (1993). The effecct of Amperozide
on schedule-induced polydipisa (SIP) in rats. *Society for Neuroscience
Abstracts* 19:170.

**Wu WH**, Florence SL, Kaas JH (1994). Effects of neonatal monocular
aphakia on the morphology afferent axons to layer IV of striate cortex
in macaque monkeys. *Society for Neuroscience Abstracts* 20:465.

**Wu WH**, Beck PD, Kaas JH (1995). Ipsilateral cortical connections of
S1 (3b) in prosimian primates: evidence for five somatosensory areas.
*Society for Neuroscience Abstracts* 21:112.

**Wu WHC**, Beck PD, Kaas JH (1996). Cortical and thalamic connections
of the second somatosensory area, S2 in the prosimian primate, *galago
garnetti*. *Society for Neuroscience Abstracts* 22:107.

Kaas JH, **Wu CWH**, Bichot NP (1997). Projections from the second (S2)
and parietal ventral (PV) somatosensory areas to the superior colliculus
in a prosimian primate. *Society for Neuroscience Abstracts* 23:1042.

**Wu CWH**, Bichot NP, Kaas JH (1997). Connections of the second (S2)
and parietal ventral (PV) somatosensory areas with frontal motor cortex:
a study combining electrorecording, microstimulation, cytoarchitecture,
and connectivity. *Society for Neuroscience Abstracts* 23:1273.

**Wu CWH**, Kaas JH (1998). Converging evidence from microstimulation,
cytoarchitecture and connections for multiple motor areas in frontal and
cingulate cortex of prosimian primates. *Society of Neuroscience
Abstracts* 24:653.

**Wu CWH**, Kaas JH (1999). Reorganization in primary motor cortex (M1)
of primates with long-standing therapeutic amputations. *Ninth Annual
Meeting of the Society for the Neural Control of Movement.* Princeville,
HI.

**Wu CWH**, Kaas JH (1999). Spinal cord contribution to reorganization
of primate primary motor cortex (M1) following long-standing limb
amputation. *Society for Neuroscience Abstracts* 25:385.

Pietrini P, Furey ML, Gobbini MI, Ricciardi E, **Wu WC**, Cohen L,
Guazzelli M, Haxby JV (2000). Activation of ventral extrastriate visual
cortex during tactile discrimination of faces and objects in
congenitally blind subjects. *Society for Neuroscience Abstracts* 26.

**Wu CWH**, Kaas JH (2000). The effects of long-standing limb amputation
on anatomical reorganization of the somatosensory afferents in the
brainstem. *Society for Neuroscience Abstracts* 26.

**Wu CWH**, Bichot NP, Kaas JH (2001). Superior colliculus connection
with physiologically identified somatosensory areas. *Annual Meeting of
the Society for the Neural Control of Movement.* Seville, Spain.

van Gelderen P, **Wu CWH**, Duyn J (2002). Spatial discrimination of
combo pulse in visual and somatosensory cortex. *International Society
for Magnetic Resonance in Medicine.* Honolulu, HI.

van Gelderen P, **Wu CWH**, Hanakawa T, Cohen LG, Hallett MM, Duyn J
(2002). Stability of perfusion and bold signals of combo pulse in motor
tapping task. *International Society for Magnetic Resonance in
Medicine.* Honolulu, HI.

**Wu CWH**, van Gelderan P, Hanakawa T, Kelin-Lang A, Dyne J, Hallett M,
Cohen LG (2002). The effects of median nerve stimulation on the motor
cortex: a fMRI study. *Society for Neuroscience Abstracts* 28. 562.11.
Miami, FL.

van Gelderen P, **Wu CWH**, Duyn J (2002). Comparing spatial
discrimination of perfusion and bold fMRI*. Human Brain Mapping,*
Sendai, Japan*.*

Pietrini P, Furey ML, Ricciardi E, Gobbini MI, **Wu WC**, Cohen L,
Guazzelli M, Haxby JV (2002). Neuroal activity in ventral extrastriate
cortex during tactile discrimination of faces and objects in
congenitally blind and sighted subjects. *International Conference on
Functional Mapping of the Human Brain*, Sendai, Japan.

**Wu CWH**, Werhahn KJ., Stefan K, Seo HJ, Floel A, Cohen LG (2003).
Neural substrates mediating enhanced tactile spatial acuity during acute
anesthesia. *International Brain Research Organization*, Prague, Czech
Republic.

Sawaki L, **Wu C**, Stefan K, Yaseen C, Robinson C, Cohen LG (2003).
Training-dependent encoding of motor memory in patients with chronic
stroke. *American Academy of Neurology,* Hawaii, HI.

**Wu CWH**, Werhahn KJ., Stefan K, Seo HJ, Floel A, Cohen LG (2003).
Neural substrates underlying enhanced tactile spatial acuity (TSA)
during acute hand deafferentation. *Society for Neuroscience Abstracts*,
New Orlanes.

Floel A, Poeppel D, Bufflo E, Braun A. **Wu C**, Seo HJ, Stefan K,
Knecht S, Cohen L (2003). Frontal cortex symmetry for memory encoding of
words and pictures. *Society for Neuroscience Abstracts*, New Orlanes.

**Wu CWH**, Seo HJ, Cohen LG (2004). Improvement of paretic hand
function by somatosensory stimulation in chronic stroke. Submitted to
*World Stroke Congress*, Vancouver.

Sawaki L, **Wu CWH**, Cohen LG (2004). Enhancement of use-dependent
plasticity by peripheral nerve stimulation in patients with chronic
stroke. Submitted to *American Academy of Neurology*, San Francisco.

Hummel F, **Wu C**, Floel A, Gerloff C, Cohen LG (2004). Effects of
transcranial direct current stimulation (tDCS) on motor function in
patients with chronic stroke. Submitted to *American Academy of
Neurology*, San Francisco.

**Wu CWH**, Werhahn KJ, Stefan K, Seo HJ, Floel A, Cohen LG (2004).
Cortical substrates underlying enhancement in tactile spatial acuity
(TSA) in one hand by acute deafferentation of the other hand. Submitted
to *International Conference on Functional Mapping of the Human Brain*,
Budapest, Hungary.

Hummel F, **Wu C**, Giraux P, Gerloff C, Cohen LG (2004). Improvement of
skilled motor functions in elderly healthy volunteers by cortical
stimulation. Submitted to *International Conference on Functional
Mapping of the Human Brain*, Budapest, Hungary.