Dr. VINCENZO COPPOLA

Staff Scientist

Mouse Cancer Genetics Program,

Bldg.560 Room 32-40D

PO Box B

Frederick, MD 21702

USA

Phone: 301-846-5805

Fax: 301-846-7017

e-mail: <coppolav@ncifcrf.gov>

# CURRICULUM VITAE

## PERSONAL

Name Vincenzo COPPOLA

Date and Place of Birth: January 12, 1966; Tarvisio (UD), Italy

Citizenship: Italian

Immigration status: Permanent Resident

## EDUCATION

Maturita' Classica (Diploma) Liceo Classico "Plinio Seniore"(60/60),
Castellammare di Stabia, NA, Italy, 1985

> MD (*summa cum laude*) (Laurea) Medicina e Chirurgia (*110/110 with
> honors*), II Facolta' di Medicina e Chirurgia, University "Federico
> II" of Napoli, Italy, 1991.
>
> Residency Medical Sciences (*summa cum laude)* (Enrollment in the
> National Board of Physicians), University of Napoli, Italy, 1992.
>
> USA Board Certification United States Medical Licensing Examination
> Certificate
>
> Specialization Specialization in Oncology (*summa cum laude),*
> University of Padova, Italy, 1997.

##### 

##### BACKGROUND

1999. Undergraduate Student, Medical Oncology Institute, University of
      Napoli, Italy.

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1997. Specialization in Oncology, University of Padova, Italy.

> 1997-2001 Postdoctoral Fellow, Neural Development Group, Mouse Cancer
> Genetics Program, NCI-Frederick, MD, USA
>
> 2001-present Staff Scientist, Mouse Cancer Genetics Program,
> NCI-Frederick, MD, USA

#### AFFILIATIONS 

> Member of the Italian Cooperative Group in Immunology (GCI)

**PUBLICATIONS**

1\) P. Correale, A. Procopio, L. Celio, M. Caraglia, G. Genua, **V.
Coppola**, S. Pepe, N. Normanno, I. Vecchio, G. Palmieri, S. Montagnani,
P. Tagliaferri,and, and A.R. Bianco. Phorbol 12-myristate13-acetate
induces resistance of human melanoma cells to natural-killer and
lymphokine activated killer mediated cytotoxicity. Cancer Immunol.
Immunother. 34: 272-278, 1992.

2\) A. Amadori, A. Veronesi, **V. Coppola**, M.L. Veronese, L. Bruni, E.
D\'Andrea, M. Montagna, and L. Chieco-Bianchi. EBV-associated fatal
lymphoproliferation in SCID mice injected with human leukocytes. In:
Epstein-Barr Virus and associated diseases. T.Tursz ed., John Libbey and
Co., 225, 443-448, 1993.

3\) M.L. Veronese, A. Veronesi, L. Bruni, **V**. **Coppola**, E.
D\'Andrea, A. Del Mistro, S. Mezzalira, M. Montagna, G. Ruffatto, A.
Amadori, and Chieco-Bianchi L. Properties of tumors arising in SCID mice
injected with PBMC from EBV-positive donors. Leukemia 8, s1, s214-s217,
1994.

4\) M. Murgia, M. Mion, L. Veronese, M. Panozzo, **V. Coppola**, R.
Rizzuto, M. Brini, F. Malavasi, A. Amadori, L. Chieco-Bianchi and T.
Pozzan. Cytosolic free calcium concentration in the mitogenic
stimulation of T lymphocytes by anti-CD3 monoclonal antibodies. Cell
Calcium 16, 167-180, 1994.

5\) A. Veronesi, **V. Coppola**, M. L. Veronese, C. Menin, L. Bruni, E.
D\'Andrea, M. Mion, A. Amadori, and L. Chieco-Bianchi.
Lymphoproliferative disease in human
peripheral-blood-mononuclear-injected SCID mice. II. Role of host and
donor factors in tumors generation. Int J Cancer: 59, 676-683, 1994.

6\) M. Caraglia, A.M. Libroia, S. Corradino, **V. Coppola**, R.
Guarrasi,C. Barile, G. Genua, A.R. Bianco, P. Tagliaferri.
Alpha-interferon induces depletion of intracellular iron content and
upregulation of functional transferrin receptors on human epidermoid
cancer KB cells. Biochem. Biophys. Res. Commun. 203 (1): 281-288, 1994.

7\) A. Veronesi, **V. Coppola**, C. Menin, L. Bruni, G. Esposito, M.
Mion, B. Corneo, E. D\'Andrea, A. Amadori and L. Chieco-Bianchi.
Lymphoproliferative disease in human PBMC-injected SCID mice. III.
Preliminary results on the effects of interferon-alpha-2b treatment on
lymphoma development. Fundamental and Clinical Immunology, 3(1): 33-39,
1995.

8\) S. Indraccolo, M. Mion, R. Zamarchi, **V. Coppola**, F. Calderazzo,
A. Amadori, and L. Chieco-Bianchi. A CD3+CD8+ T cell population lacking
CD5 antigen expression is expanded in peripheral blood of human
immunodeficiency virus-infected patients. Clin. Immunol. Immunopat.
77(3): 253-261, 1995.

9\) C. Menin, L.Ometto, A. Veronesi, M. Montagna, **V. Coppola**, M. L.
Veronese, S. Indraccolo, L. Bruni, B. Corneo, A. Amadori, A. De Rossi,
L. Chieco-Bianchi, and E. D\'Andrea. Dominance of a single Epstein-Barr
virus strain in SCID-mouse tumors induced by injection of peripheral
blood mononuclear cells from healthy human donors. Virus Res, 36:
215-231, 1995.

10\) A. Amadori, R. Zamarchi, S. Indraccolo, M. Mion, **V. Coppola**, F.
Calderazzo, E. Santagostino, A. Gringeri, L. Chieco-Bianchi. Immune
parameters in the natural history of HIV infection. In: Immunologia,
acura di F. Dammacco, Monduzzi ed.,Bologna,Italy, 129-135, 1995.

11\) A. Amadori, A. Veronesi, , **V. Coppola**, S. Indraccolo, M. Mion
and L. Chieco-Bianchi. The hu-PBL-SCID mouse in human lymphocyte
function and lymphomagenesis studies: achievements and caveats. Seminars
in IMMUNOLOGY vol 8, 249-254, 1996.

12\) C. Menin, L.Ometto, A. Veronesi, S. Roncella, B. Corneo, M.
Montagna, **V. Coppola**, M. L. Veronese, S. Indraccolo, A. Amadori, A.
De Rossi, M Ferrarini, L. Chieco-Bianchi, and E. D\'Andrea. Analysis of
Epstein-Barr virus (EBV) type and variant in spontaneous lymphoblastoid
cells snd hu-SCID-mouse tumors. Molecular and Cellular Probes 10,
453-461, 1996.

13\) **V. Coppola**, A. Veronesi, S. Indraccolo, F. Calderazzo, , M.
Mion, S. Minuzzo, G. Esposito, D. Mauro, B. Silvestri, P. Gallo, P.
Falagiani, A. Amadori L. Chieco-Bianchi. Lymphoproliferative disease in
human PBMC-injected SCID mice. IV. Differential activation of human Th1
and Th2 Lymphocytes and influence of the atopic status on lymphoma
development. J. Immunol.160: 2514-2522, 1998.

14\) B. Silvestri, F. Calderazzo, **V. Coppola**, A. Rosato, S.
Iacobelli, C. Natoli, A. Ullrich, I Sures, M. Azam, C. Brakebush, L.
Chieco-Bianchi, A. Amadori. Differential effect on TCR:CD3 stimulation
of a 90-kD glycoprotein (gp90/Mac-2BP), a member of the scavenger
receptor cysteine-rich domain protein family. Clin. Exp. Immunol. 113:
394-400, 1998.

15\) M.E. Palko, **V. Coppola**, and L. Tessarollo. Evidence for a role
of truncated trkC receptor isoforms in mouse development. J.
Neuroscience 19(2): 775-782, 1999.

16\) R. Zamarchi, S. Indraccolo, S. Minuzzo, **V. Coppola**, A.
Gringeri, E. Santagostino, E. Vicenzi, G. De Silvestro, R. Biagiotti, C.
Baldassarre, L. Chieco-Bianchi, and Amadori A. Frequency of a mutated
CCR-5 allele (delta32) among Italian healthy donors and individuals at
risk of parenteral HIV infection. AIDS Res Hum Retroviruses 1999 Mar
1;15(4):337-44

17\) W. E. Lyons, L. A. Mamounas, G. A. Ricaurte, **V. Coppola**, S. W.
Reid, S. H. Bora,C. Wihler, V. E. Koliatsos and Lino Tessarollo.
Brain-derived neurotrophic factor-deficient mice develop aggressiveness
and hyperphagia in conjunction with brain serotonergic abnormalities.
PNAS 1999 96: 15239-15244.

18\) **V. Coppola**, J. Kucera, M.E. Palko, J. Martinez-De Velasco,W. E.
Lyons, B. Fritzsch and L. Tessarollo Dissection of NT-3 functons in vivo
by gene replacement with BDNF. Development 2001 Nov, vol 128
(21):4315-27.

19\) I. Farinas, K.R. Jones, L. Tessarollo, A.J. Vigers, E. Huang, M.
Kirstein, D.C. de Caprona, **V. Coppola**, C. Backus, L.F. Reichardt,
and B. Fritzsch. Spatial shaping of cochlear innervation by
temporally-regulated neurotrophin expression. J Neurosci. 2001 Aug
15;21(16):6170-80.

20\) S. Akbarian, B.Bates, R-J. Liu, S.L. Skirboll, T. Pejchal, **V.
Coppola**, L.D. Sun, G.P. Fan, J. Kucera, M.A. Wilson, L. Tessarollo,
B.E. Kosofsky, J.R. Taylor, M. Bothwell, E.J. Nestler, G.K. Aghajanian
and R. Jaenish. Neurotophin-3 is essential for noradrenergic neuron
function and opiate withdrawal. Molecular Psychiatry, 2001
Sep;6(5):593-604.

21\) S.M. Wilson, D.B. Householder, **V. Coppola**, L. Tessarollo, B.
Fritzsch, E-C Lee, D Goss, G.A. Carlson N.G. Copeland, and N.A. Jenkins.
Mutations in Cdh23 cause nonsyndromic hearing loss in *waltzer* mice.
Genomics. 2001 Jun 1;74(2):228-33.

22\) Saller RM, Indraccolo S, **Coppola V**, Esposito G, Stange J,
Mitzner S,

Amadori A, Salmons B, Gunzburg WH. Encapsulated cells producing

retroviral vectors for in vivo gene transfer. J Gene Med. 2002 Mar-

Apr;4(2):150-60.

23\) Celeste A, Petersen S, Romanienko PJ, Fernandez-Capetillo O, Chen
HT, Sedelnikova OA, Reina-San-Martin B, **Coppola V**, Meffre E,
Difilippantonio MJ, Redon C, Pilch DR, Olaru A, Eckhaus M,
Camerini-Otero RD, Tessarollo L, Livak F, Manova K, Bonner WM,
Nussenzweig MC, Nussenzweig A. Genomic Instability in Mice Lacking
Histone H2AX. Science. 2002 May 3;296(5569):922-7.

24\) Akbarian S, Rios M, Liu RJ, Gold SJ, Fong HF, Zeiler S, **Coppola
V**, Tessarollo L, Jones KR, Nestler EJ, Aghajanian GK, Jaenisch R.
Brain-derived neurotrophic factor is essential for opiate-induced
plasticity of noradrenergic neurons. J. Neurosci. 2002 May
15;22(10):4153-62.

25\) Wilson SM, Bhattacharyya B, Rachel RA, **Coppola V**, Tessarollo L,
Householder DB, Fletcher CF, Miller RJ, Copeland NG, and Jenkins NA.
Synaptic defects in ataxia mice result from a mutation in the USP14
encoding a ubiquitin-specific protease gene. Nature Genetics, 2002 Nov
32:420-5.

26\) Berthet C., Aleem E., **Coppola V**., Tessarollo L., and Kaldis P.
Cdk2 knockout mice are viable. Current Biology 2003, vol. 13, 1775-1785.

27\) Sharan SK, Pyle A., **Coppola V.**, Babus J., Swaminathan S.,
Benedict J., Swing D., Martin BK., Tessarollo L., Evans JP, Flaws JA.,
and Handel MA. BRCA2 deficiency in mice leads to meiotic impairment and
infertility. Development, 2004; 131 131-142.

28\) Fritzsch B., Tessarollo L., **Coppola V**., and Reichardt LF.
Neurotrophins in

the ear: their roles in sensory neuron survival and fiber guidance. Prog

Brain Res. 2004;146:265-78.

29\) Tessarollo L., **Coppola V**., and Fritzsch B. NT-3 replacement
with brain-

derived neurotrophic factor redirects vestibular nerve fibers to the

cochlea. J Neurosci. 2004; 24: 2575-84.

30\) **Coppola V**, Barrick CA, Southon EA, Celeste A, Wang K, Chen B,
Haddad

el-B, Yin J, Nussenzweig A, Subramaniam A, Tessarollo L. Ablation of

TrkA function in the immune system causes B cell abnormalities.

Development. 2004 Oct;131(20):5185-95.

31\) **Coppola V**. and Tessarollo L. Control of Hyperphagia prevents
obesity in

BDNF heterozygous mice. Neuroreport 2004 Dec 3;15(17):2665-8.

32\) Catalano A, Rodilossi S, Caprari P, **Coppola V**, Procopio A.
5-Lipoxygenase

regulates senescence-like growth arrest by promoting ROS-dependent

p53 activation. EMBO J. 2005 Jan 12;24(1):170-9.

33\) Esteban PF, Yoon HY, Becker J, Dorsey SG, Caprari P, Palko ME,
**Coppola**

**V**, Saragovi HU, Randazzo PA, Tessarollo L. A kinase-deficient TrkC

receptor isoform activates Arf6-Rac1 signaling through the scaffold
protein

tamalin. J Cell Biol. 2006 Apr 24;173(2):291-9.

34\) [**Coppola V**, Barrick CA, Bobisse S, Rodriguez-Galan MC, Pivetta
M, Reynolds D, Howard OM, Palko ME, Esteban PF, Young HA, Rosato A,
Tessarollo
L.](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16809763&query_hl=1&itool=pubmed_docsum)
The scaffold protein cybr is required for cytokine-modulated trafficking
of leukocytes in vivo. Mol Cell Biol. 2006 Jul;26(14):5249-58.