CURRICULUM VITAE

Date Prepared: March 30th, 2007

**Name:** Julio C. Valencia, M.D.

**Citizenship:** Perú

**Visa Status:** H1-B

**Education:**

> April 1997 M.D.: San Fernando Medical School. San Marcos University,
> Lima, Perú
>
> April 1997 B.S.: San Fernando Medical School. San Marcos University,
> Lima, Perú

**Brief Chronology of Employment:**

> 1996 - 1997 *Internship*, Edgardo Rebagliatti Martins Hospital,
> Peruvian Social Security Administration, Lima, Perú
>
> 1997 - 1998 *Chief*, Acoria Health Center, Huancavelica, Perú
>
> 1998 --1998 *Director of Epidemiology*. Peruvian Health Ministry,
> Huancavelica, Perú
>
> 1999 - 2002 *Postdoctoral fellow*, Pathology and Pulmonary and
> Critical Care Medicine branch, National Heart, Lung and Blood
> Institute; National Institutes of Health, Bethesda, Maryland
>
> 2003 *Postdoctoral fellow,* Laboratory of Cell Biology, Pigment Cell
> Biology Section, National Cancer Institute, National Institutes of
> Health, Bethesda, Maryland
>
> 2004 *Research Fellow,* Laboratory of Cell Biology, Pigment Cell
> Biology Section, National Cancer Institute, National Institutes of
> Health, Bethesda, Maryland
>
> 2006 *Staff Scientist*, Laboratory of Cell Biology, Pigment Cell
> Biology Section, National Cancer Institute, National Institutes of
> Health, Bethesda, Maryland

## Societies:

United States and Canadian Academy of Pathology 2000 -- 2005.

> Scientific Society of Medical Students and the Latin American
> Federation of Medical Students (FELSOCEM)

Scientific Society of the San Fernando Medical School. San Marcos
University. Lima, Peru

**Awards and Honors**

Medical education Award, VII National Scientific Congress of Medical
Students. "Alberto Hurtado" Medical School -- Cayetano Heredia
University. Lima, Peru. 1994

Clinical Sciences Award, VII National Scientific Congress of Medical
Students. "Alberto Hurtado" Medical School -- Cayetano Heredia
University. Lima, Peru. 1994

> Medical Education Award, X International Scientific Congress of
> Medical Students. University of Buenos Aires, Medical School. Buenos
> Aires, Argentina. 1995
>
> Award for the outstanding work performed promoting scientific research
> for medical students given by the president of the Peruvian Scientific
> Society of Medical students, San Marcos University. Lima, Peru. 1996
>
> Medical Sciences Award, IX Scientific Congress of Medical Students.
> School of Medicine. National University "Pedro Ruiz Gallo".
> Lambayeque, Peru. 1997

Award given by the Senior Advisor of the Population Council of Peru in
recognition of the work done as first author of the research work and
report on the practice of obstetrics in Huancavelica, Peru. 1998.

> Award received for "Outstanding presentation in the congress of the
> Latin American Scientific Society" given by the Dean of the University
> of Sinaloa. Culiacan Rosales, Sinaloa, Mexico. 1998.

Travel Award from the LAM foundation to attend the LAM / NHLBI
conference in Cincinnati, OH, on April 4^th^ -6^th^, 2003

**Invited Seminars**

Invited seminar for the Laboratory of Cell Biology NCI/NIH titled "The
sorting of human Pmel17 (gp100) and the role of the Adaptor Protein
complexes 1 and 2," April 2004.

Invited seminar to the Pulmonary-Critical Care Medicine Branch NHLBI /
NIH titled: "New trends in Melanoma Basic Research and its impact on
understanding malignant transformation,\" January 2006.

Invited seminar for the Laboratory of Cell Biology NCI/NIH titled
"Revealing the melanosome code: From Skin protection to cell
resistance," November 2006.

**Selected Presentations as Speaker**

Oral Presentation American Thoracic Society (ATS-2000). May 5-10^th^,
2000

Oral Presentation United States and Canadian Academy of Pathology
(USCAP), 2001

Oral Presentation American Thoracic Society (ATS-2002). May 17-22^nd^,
2002

Oral Presentation 11^th^ PanAmerican Society for Pigment Cell Research
Meeting. 2003.

Oral Presentation "The LAM foundation/NHLBI Research conference in
Cincinnati, Ohio. April 4-6, 2003.

Oral Presentation 12^th^ PanAmerican Society for Pigment Cell Research
Meeting. 2004.

Oral Presentation at the CCR Fellows and Young Investigators Retreat,
Williamsburg, VA, February 2005.

Oral Presentation International Pigment Cell Conference, Reston, VA,
September 2005.

Oral Presentation International Pigment Cell Conference, Barcelona,
Spain, September 2006.

**BIBLIOGRAPHY**

#### Julio C. Valencia, M.D.

**Articles**

1.  [Valencia, J.C.,]{.underline} Villavicencio, M., Vicuna, R., Torre,
    P., and Torres, E. Acute effect of Aloe vera linneo and Ciclanthera
    pedata shrad in diabetic rats. Rev. Med. Peruana. 66 (351): 80-82,
    1994.

2.  Arrus-Soldi, J., Barrenechea, L., Bermudez-Garcia, A.,
    Huby-Vidaurre, M., and [Valencia, J.C.]{.underline} Analysis of
    human resourses for predoctoral scientific research in medical
    school, Peru 1993. Rev. Med. Peruana. 67 (352): 29-32,1995.

3.  [Valencia, J.C.]{.underline}, Bambaren, C., Alfaro, M., Canales, J.,
    Romero, M., Villavicencio, A., Vargas, P., Obando, L., Lance, L.,
    Bonelli, L., Abad, R., Angeles, L., Bolanos, E., Campos, D., and
    Uriol, M. Epidemiological aspects of Rheumatoid Arthritis at the
    rheumatology service Peruvian Air Force Hospital (HCFAP) 1976-1992.
    Ann. Fac. Med. Lima. 56 (1) : 13-16, 1995.

4.  Ferrans, V. J., Yu, Z. X., Nelson, W.K., [Valencia, J.
    C]{.underline}., Tatsuguchi, A., Avila, N. A., Riemenschnaider, W.,
    Matsui, K., Travis, W. D., Moss, J.: Lymphangioleiomyomatosis (LAM):
    a review of clinical and morphological features. *J. Nippon Med.
    Sch*. 67: 311-329, 2000.

5.  Matsui, K., Takeda, K., Yu, Z. X., [Valencia, J.]{.underline},
    Travis, W. D., Moss, J., Ferrans, V. J.: Downregulation of estrogen
    and progesterone receptors in the abnormal smooth muscle cells in
    pulmonary Lymphangioleiomyomatosis following therapy. An
    immunohistochemical study. *Am J Respir Crit Care Med.* 161:
    1002-1009, 2000.

6.  [Valencia, J. C]{.underline}., Matsui, K., Tatsuguchi, A.,
    Rasmussen, A., Cullen, K., Moss, J., and Ferrans, V. J.:
    Distribution and mRNA expression of Insulin-like growth factor
    system in pulmonary Lymphangioleiomyomatosis (LAM). *J. Invest.
    Med*. 49: 421-433, 2001.

7.  Virador, V., Matsunaga, N., Matsunaga, J., [Valencia, J.
    C.,]{.underline} Oldham, R. J., Kameyama, K., Peck, G. L.,
    Ferrans, V. J., Vieira, W. D., Abdel-Malek, Z. D., and Hearing, V
    J.: Production of melanocyte-specific antibodies to human
    melanosomal proteins: Expression patterns in normal human skin and
    in cutaneous pigmented lesions. *Pigment Cell Res.* 14: 289-297,
    2001.

8.  Kushimoto, T., Basrur, V., [Valencia, J. C.,]{.underline} Matsunaga,
    J., Vieira, W. D., Ferrans, V. J., Muller, J., Appella, E., and
    Hearing, V. J.: A Model for Melanosome Biogenesis Based on the
    purification and Analysis of early melanosomes. *Proc. Natl. Acad.
    Sci. USA* 98: 10698-10703, 2001.

9.  Toyofuku, K., Wada, I., [Valencia, J. C.]{.underline}, Kushimoto,
    T., Ferrans, V. J., and Hearing, V. J.: Oculocutaneous albinism
    types 1 and 3 are ER retention diseases: mutation of tyrosinase or
    tyrp1 affects the processing of both mutant and wild-type proteins.
    *FASEB J*. 15: 2149-2161, 2001.

10. Toyofuku, K., [Valencia, J.C.]{.underline}, Kushimoto, T., Costin,
    G.E., Virador, V.M., Vieira, W.D., Ferrans, V.J., and Hearing, V.J.
    The etiology of oculocutaneous albinism (OCA) type II: the pink
    protein modulates the processing and transport of tyrosinase.
    *Pigment Cell Res.* 15:217-24, 2002.

11. Basrur, V., Yang, F., Kushimoto,T., Higashimoto, Y., Yasumoto, K.,
    [Valencia, J. C.]{.underline}, Muller, J., Vieira, W. D., Watabe,
    H., Shabanowitz, J., Hearing, V. J., Hunt, D. F., and Appella,E.:
    Proteomic Analysis of Early Melanosomes: Identification of Novel
    Melanosomal Proteins. *J. Prot. Res.* 2: 69-79, 2003.

12. Kushimoto, T., [Valencia, J. C.]{.underline}, Costin, Gertrude-E.,
    Toyofuku, K., Watabe, H., Yasumoto, Ken-ichi., Rouzaud, F.,
    Vieira, W. D., and Hearing, V. J.: The Seiji Memorial lecture: The
    melanosome an Ideal Model to Study Cellular Differentiation.
    *Pigment Cell Res.* 16(3):237-244, 2003.

13. Costin, G. E., [Valencia, J .C.]{.underline}, Vieira,W. D.,
    Lammoreux, M. L., and Hearing, V. J.: Tyrosinase processing and
    intracellular trafficking is disrupted in mouse primary melanocytes
    carrying the *underwhite (uw)* mutation. A model for oculocutaneous
    albinism (OCA) type 4. *J. Cell Sci*. 1116: 3203-3212, 2003.

14. Rouzaud, F., Annereau, J. P., [Valencia, J. C]{.underline}.,
    Costin, G. E., and Hearing, V. J.: Regulation of melanocortin 1
    receptor expression at the mRNA and protein levels by its natural
    agonist and antagonist. *FASEB J.* 17(14): 2154-2156, 2003.

15. Watabe, H., [Valencia, J.C.]{.underline}, Yamaguchi, Y., and
    Hearing, V. J.: Physiological regulation of skin and hair
    pigmentation. *J. Clin. Dermatol*. 32: S2-S8, 2003.

16. Watabe, H., [Valencia, J. C]{.underline}., Yasumoto, K., Kushimoto,
    T., Ando, H., Vieira, W. D., Mizoguchi, M., Apella, E., and
    Hearing, V. J.: Regulation of tyrosinase processing and trafficking
    by organellar pH and by proteosome activity. *J. Biol. Chem*. 279:
    7971-7981, 2004.

17. Ando, H., Watabe, H., [Valencia, J. C.]{.underline}, and Hearing, V.
    J.: Fatty acids regulate pigmentation via proteasomal degradation of
    tyrosinase - A new aspect of ubiquitin-proteasome function. *J.
    Biol. Chem.* 279(15): 15427-33, 2004.

18. Yasumoto, K. I., Watabe, H., [Valencia, J. C.]{.underline},
    Kushimoto, Y., Kobayash, I. T., Appella, E., and Hearing, V. J.:
    Epitope mapping of the melanosomal matrix protein gp100 (PMEL17):
    Rapid processing in the endoplasmic reticulum and glycosylation in
    the early Golgi compartment. *J. Biol. Chem.* 279 (27): 28330-28338,
    2004.

19. Costin, G. E., Vieira, W. D., [Valencia, J. C.]{.underline},
    Rouzaud, F., Lamoreux, L. M., and Hearing, V. J.: Immortalization of
    mouse melanocytes carrying mutations in various pigmentation genes.
    *Anal. Biochem.* 355(1): 171-174, 2004.

20. Chen, K. G., Szakács, G., Annereau, J. P., Rouzaud, F., Liang, X.
    J., [Valencia, J. C.,]{.underline} Nagieni, C. N., Hooks, J. J,
    Hearing, V. J., and Gottesman, M. M.: Principal expression of two
    mRNA isoforms (ABCB5a and ABCB5b) of the ATP-binding cassette
    transporter gene ABCB5 in melanoma cells and melanocytes. *Pigment
    Cell Res.* 18(2): 102-112, 2005.

21. [Berens, W., Van Den Bossche, K., Yoon, T. J., Westbroek, W.,
    [Valencia, J. C.]{.underline}, Out, C. J., Marie-Naeyaert, J.,
    Hearing, V. J., and Lambert,
    J.](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16162177&query_hl=1&itool=pubmed_docsum):
    Different approaches for assaying melanosome transfer. *Pigment Cell
    Res*. 18(5): 370-381, 2005.

22. [Costin, G. E., [Valencia, J. C.]{.underline}, Wakamatsu, K., Ito,
    S., Solano, F., Milac, A. L, Vieira, W. D., Yamaguchi, Y., Rouzaud,
    F., Petrescu, A. J., Lamoreux, M. L., and Hearing, V.
    J.](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15960609&query_hl=1&itool=pubmed_docsum):
    Mutations in dopachrome tautomerase (Dct) affect
    eumelanin/pheomelanin synthesis, but do not affect intracellular
    trafficking of the mutant protein. *Biochem. J*. 391(Pt 2): 249-259,
    2005.

23. [Ando, H., Wen, Z. M., Kim, H. Y., [Valencia, J. C.]{.underline},
    Costin, G. E., Watabe, H., Yasumoto, K., Niki, Y., Kondoh, H.,
    Ichihashi, M., and Hearing, V.
    J.](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16232122&query_hl=1&itool=pubmed_docsum):
    Intracellular composition of fatty acid affects the processing and
    function of tyrosinase through the ubiquitin-proteasome pathway.
    *Biochem. J*. 394(Pt 1): 43-50, 2006.

24. [[Valencia, J. C.]{.underline}, Pacheco-Rodriguez, G., Carmona, A.
    K., Xavier, J., Bruneval, P., Riemenschneider, W. K., Ikeda, Y.,
    Yu, Z. X., Ferrans, V. J., and Moss,
    J.](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16474096&query_hl=1&itool=pubmed_docsum):
    Tissue-specific renin-angiotensin system in pulmonary
    lymphangioleiomyomatosis (LAM). *Am. J. Respir. Cell. Mol. Biol*.
    35: 40-47, 2006.

25. [Valencia, J. C.]{.underline}, Watabe, H., Chi, A., Rouzaud, F.,
    Chen, K. G., Vieira, W. D., Takahashi, K., Yamaguchi, Y., Berens,
    W., Nagashima, K., Shabanowitz, J., Hunt, D. F., Appella, E., and
    Hearing, V. J.: Sorting of Pmel17 to melanosomes through the plasma
    membrane by AP1 and AP2: evidence for the polarized nature of
    melanocytes. *J. Cell Science* 119 (Pt. 6): 1080-1091, 2006.

26. [Valencia, J. C.]{.underline}, Hoashi, T., Pawelek, J. M., Solano,
    F., and Hearing, V. J.: Pmel17: controversial indeed but critical to
    melanocyte function. *Pigment Cell Res*. 19: 257, 2006.

27. [Valencia, J. C.]{.underline}, Hoashi, T., Pawelek, J. M., Solano,
    F., and Hearing, V. J.: Reply to the response to our letter.
    *Pigment Cell Res*. 19: 257, 2006.

28. Chen, K. G., [Valencia, J. C.]{.underline}, Lai, B., Zhang, G.,
    Paterson, J. K., Rouzaud, F., Berens, W., Wincovitch, S. M.,
    Garfield, S. H., Leapman, R. D., Hearing, V. J., and Gottesman, M.
    M.: Melanosomal sequestration of cytotoxic drugs contributes to the
    intractability of malignant melanomas. *Proc. Natl. Acad. Sci. USA*
    103: 9903-9907, 2006.

29. Rouzaud, F., Costin, G. E., Yamaguchi, Y., [Valencia, J.
    C]{.underline}., Berens, W. F., Chen, K. G., Hoashi, T., Bohm M.,
    Abdel-Malek, Z. A., and Hearing, V. J.: Regulation of constitutive
    and UVR-induced skin pigmentation by melanocortin 1-receptor
    isoforms. FASEB J. 20: 1927-1929, 2006.

30. Chi\*, A., [Valencia\*, J. C]{.underline}., Hu\*, Z. Z., Watabe, H.,
    Yamaguchi, H., Mangini, N. J., Huang, H., Canfield, V. A, Cheng, K.
    C., Yang, F., Abe, R., Yamagishi, S., Shabanowitz, J., Hearing, V.
    J., Wu, C., Appella, E., and Hunt, D. F.: Proteomic and
    bioinformatic characterization of the biogenesis and function of
    melanosomes. *J. Proteome Res*. 5: 3135-3144, 2006. \*These authors
    share first authorship.

31. Hu, Z.Z., Valencia, J.C., Huang, H., Chi, A., Shabanowitz, J.,
    Hearing, V.J., Appella, E., and Wu, C. Comparative bioinformatics
    analyses and profiling of Lysosome-related organelles proteomes.
    *Int. J. Mass Spec.* 259: 147-160, 2007.

32. [Valencia, J.C.]{.underline}, Rouzaud, F., Julien S., Chen, K.G.,
    Passeron, T., Yamaguchi, Y., Abu-Asab, M., Tsokos, M., Costin, G.E.,
    Yamaguchi, H., Miller-Jenkins, L., Nagashima, K., Appella, E., and
    Hearing., V.J. Sialylated core 1-O-glycans influence the sorting of
    Pmel17/gp100 and determine its capacity to form fibrils. *J. Biol.
    Chem.* Feb 15 \[Epub ahead of print\], 2007.

33. Watabe\*, H., [Valencia\*, J.C.,]{.underline} Le Pape, E.,
    Yamaguchi, Y., Nakamura, M., Rouzaud, F., Hoashi, T., Kawa, Y.,
    Mizoguchi, M., and Hearing, V.J. Involvement of Dynein and Spectrin
    with ealy melanosome transport and melanosomal protein trafficking.
    *J. Invest. Derm.* 2007 \[In Press\]. \*These authors share first
    authorship.

**Book chapters**

1.  Watabe, H., Kushimoto, T., [Valencia, J. C.]{.underline}, and
    Hearing, V. J.: Isolation of Melanosomes. Book chapter: Subcellular
    fractionation and isolation of organelles. Isolation of Melanosomes.
    *Curr. Protocols Cell Biol. Suppl* 26: 3.14.1-3.14.15, 2005.

**Abstracts**

1.  Matsui, K., Tatsuguchi, A., [Valencia, J. C]{.underline}., Yu, ZX.,
    Bechtle, J., Beasley, M. B., Avila, N., Travis, W. D., Moss, J.,
    Ferrans, V. J.: Extrapulmonary Lymphangioleiomyomatosis (LAM):
    clinicopathologic features in 22 cases. *Hum Pathol*. 31: 1242-1248,
    2000.

2.  [Valencia, J. C.]{.underline}, Matsui, K., Yu, Z. X., Tatsuguchi,
    A., Moss, J., and Ferrans, V. J.: Expression of melanocortins
    hormones in smooth muscle cells in pulmonary
    Lymphangioleiomyomatosis (LAM). *Am J Respir Crit Care Med*.161:
    A377, 2000.

3.  Tatsuguchi A., Matsui, K., [Valencia, J. C.]{.underline}, Fukuda,
    Y., Moss, J., Ferrans, V. J., and Yu, Z. X.: Immunohistochemical
    localization of contractile proteins in pulmonary
    Lymphangioleiomyomatosis (LAM). *Am. J. Respir. Crit. Care Med*.
    161: A15, 2000.

4.  Yu, Z. X., Pacheco, G., Takeda, K., Stevens, L., [Valencia, J.
    C.]{.underline}, Tatsuguchi, A., Moss, J., and Ferrans, V. J.:
    Isolation of HMB-45 positive smooth muscle cells (LAM Cells) from
    lung tissue from patients with Lymphangioleiomyomatosis. *Am. J.
    Respir. Crit. Care Med.* 161: A376, 2000.

5.  [Valencia, J. C.]{.underline}, Yu, Z. X., Moss, J., and Ferrans, V.
    J.: Ultrastructural identification of melanosomes using DOPA-Silver
    reaction in pulmonary Lymphangioleiomyomatosis (LAM). *Am. J Respir
    Crit Care Med*. 164: A711, 2001.

6.  Kumaki, F., [Valencia, J.C.]{.underline}, Tatsuguchi, K., Takeda,
    K., Yu, Z., Moss,J., and Ferrans V.J. Expression of Telomerase
    reverse transcriptase (TERT) in pulmonary Lymphangioleiomyomatosis
    (LAM). *Am J Respir Crit Care Med.* 163:A711, 2001.

7.  [Valencia, J. C.]{.underline}, Virador, V., Fetsch, P., Abati, A.,
    Hearing, V. J., Yu, Z. X., Moss, J., and Ferrans, V. J.:
    Melanocyte-associated proteins in Lymphangioleiomyomatosis (LAM).
    *Am J Respir Crit Care Med.* 163:A714, 2001.

8.  [Valencia, J.C.]{.underline}, Virador, V., Escobar, J.C., Moss, J.,
    and Ferrans, V.J. Localization of tissue angiotensin system in
    pulmonary Lymphangioleiomyomatosis (LAM). Mod. Pathol. 14(1):227A
    (Abstract #1338), 2001.

9.  Kumaki, F., Matsui, K., [Valencia, J.C.,]{.underline} Yu, Z., Kawai,
    T., Oseki, Y., Ferrans,V.J., and Travis, W.D. Expression of matrix
    metalloproteinases (MMPs) in pulmonary adenocarcinoma showing
    lepidic growth (ALG) and atypical adenomatous hyperplasia (AAH).
    Mod. Pathol. 14:222A (Abstract #1308), 2001.

10. [Valencia, J.C.]{.underline}, Blankinship, G.L., Yu, Z-X., Moss, J.
    and Ferrans,V.J. Expression of Microphthalmia-associated
    transcription factor (MITF) and CD63 melanoma antigen in pulmonary
    Lymphangioleiomyomatosis (LAM). *Lab. Invest.* 82(1):330A (Abstract
    #1374), 2002.

11. [Valencia, J.C.]{.underline}, Riemenschneider, W.K., Loredo, M., Yu,
    Z-X., Moss, J. and Ferrans,V.J.: Apoptosis in Type II pneumocytes in
    Lymphangioleiomyomatosis (LAM)". *Am J Respir Crit Care Med.*
    165(8):A702, 2002.

12. [Valencia, J.C.]{.underline}, Blankinship, G.L., Tsukada,K., Yu,
    Z-X., Moss, J. and Ferrans,V.J. Distribution Of Estrogen Receptors
    Alpha (ER Alpha) And Beta (ER Beta) In Pulmonary
    Lymphangioleiomyomatosis (LAM). *Am J Respir Crit Care Med.*
    165(8):A702, 2002.

13. [Valencia, J.C.]{.underline}, Yasumoto, K-I., Fetsch, P., Tsukada,
    K., Kushimoto, T., Pacheco-Rodriguez, G., Hearing, V.J., Abati, A.,
    Yu, Z-X., and Moss, J. Identification in Lymphangioleiomyomatosis
    lung nodules of a novel form of the melanosomal protein gp100 and a
    non-melanoma transcription factor, MITF-A. *Am J Respir Crit Care
    Med.* 165(8):A702, 2003.

14. [Valencia, J.C.]{.underline}, Hearing, V.J., Kushimoto, T., Fetsch,
    P., Abati, A., Yu, Z-X., Ferrans, V.J., and Moss, J. Expression of
    melanogenic proteins in pulmonary Lymphangioleiomyomatosis (LAM).
    XVIIIth International Pigment Cell Conference, The Nederland's.
    September 8-13, 2002.

15. [Valencia, J.C.]{.underline}, Yasumoto, K-I., Fetsch, P., Tsukada,
    K., Kushimoto, T., Pacheco-Rodriguez, G., Hearing, V.J., Abati, A.,
    Yu, Z-X., and Moss, J. Identification in lymphangioleiomyomatosis
    lung nodules of a novel form of the melanosomal protein Pmel17 and a
    non-melanoma transcription factor, MITF-A. The LAM foundation/NHLBI
    research conference. Cincinnati, OH, April 4-6, 2003.

16. [Valencia, J.C.]{.underline}, Watabe, H., and Hearing, V.J. The
    melanosomal protein gp100 is partially glycosylated in the
    *cis*-Golgi compartment in MNT-1 melanoma cells. *Pigment Cell Res*.
    16(4): Abstract #08. 413, 2003.

17. Watabe, H., [Valencia, J.C.]{.underline}, Yasumoto, K., Ando, H.,
    Vieira, W., Mizoguchi, M., Appella, E., and Hearing, V.J. Regulation
    of melanogenesis in amelanotic melanoma cells by pH and by
    proteosome activity. *Pigment Cell Res*. 16(4): Abstract #10. 414,
    2003.

18. Costin, G.E., [Valencia, J.C]{.underline}., Vieira,W., Lamoreux,
    M.L., and Hearing, V.J. Characterization of two new mouse melanocyte
    lines carrying the slaty and slaty light mutations. *Pigment Cell
    Res*. 16(4): Abstract #27. 419, 2003.

19. Rouzaud, F., Costin, G. E., Yamaguchi, Y., [Valencia, J.
    C]{.underline}., Chen, K. G., Bohm M., Abdel-Malek, Z. A., and
    Hearing, V. J. Expression patterns of two MC1R isoforms in human
    melanocytes and skin of various pigmentation/ethnic origin upon
    stimulation by MSH/UVR. *Pigment Cell Res.* 17: CL-09, 431, 2004.

20. [Valencia, J. C.]{.underline}, Watabe, H., Chi, A., Hunt, D. F.,
    Rouzaud, F., Appella, E., and Hearing, V. J. Human pmel17 is sorted
    to melanosomes by the adaptor protein complexes 1 and 2. *Pigment
    Cell Res.* 17: CL-13, 435, 2004.

21. Crooks, D.M. , De Castro, R.M, [Valencia, J.C.,]{.underline}
    Glasgow, C.G., Patronas, N., and Moss, J. Genetic and Hormonal
    Characterization of Meningiomas in Patients with
    Lymphangioleiomyomatosis (LAM). *Am. J. Respir. Crit. Care Med*.
    169: A228, 2004.

22. Ando, H., Watabe, H., [Valencia, J.C.,]{.underline} Yasumoto, K-I,
    Furumura, M., Funasaka, Y., Oka, M., Ichihashi, M., and Hearing,
    V.J. The regulatory mechanism of tyrosinase degradation by the
    ubiquitin-proteosome pathway. XIV International congress of
    Photobiology, June 10-15^th^, South Korea, 2004.

23. [Valencia, J.C.]{.underline}, Chi,A., Appella, E., Hunt, D.F., and
    Hearing, V.J. Melanosome proteomics II. Identification of
    trafficking molecules present in early and late melanosomes. US HUPO
    meeting. Abstract P-312. March 14^th^, 2005. Washington DC.

24. [Chi, A.]{.underline}, Valencia, J.C., Hearing, V.J., Appella, E.,
    Shabanowitz, J., and Hunt, D.F. Melanosome proteomics I.
    Purification and identification of melanosome proteins. US HUPO
    meeting. Abstract P-312. March 14^th^, 2005. Washington DC.

25. [Ando, H., Wen, Z. M., Kim, H. Y., [Valencia, J. C.]{.underline},
    Costin, G. E., Watabe, H., Yasumoto, K., Niki, Y., Kondoh, H.,
    Ichihashi, M., and Hearing, V.
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