# **NCI Summer Curriculum in**

# **Cancer Prevention**

**\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\***

**Molecular Prevention Course**

### **August 1 through 5, 2005**

**6001 Executive Boulevard**

**Conference Rooms C and D**

### **Rockville, Maryland 20852**

**301-435-1465**

#### Preliminary Syllabus

**2005**

### *U.S. Department of Health and Human Services*

*National Institutes of Health*

### *National Cancer Institute*

*Division of Cancer Prevention*

####### Office of Preventive Oncology 

# NCI Summer Curriculum in Cancer Prevention

## Molecular Prevention Course

Date: August 1 through 5, 2005

Time: 8:30 a.m. to 10:00 a.m.

10:30 a.m. to 12:00 noon

1:00 p.m. to 2:30 p.m.

Each session has a different topic and speaker

Location: 6001 Executive Boulevard

Conference Rooms C and D

Rockville, Maryland 20852

301-435-1465

Course presented by:

Office of Preventive Oncology Douglas L. Weed, PhD, MD, MPH, Director

Division of Cancer Prevention Shine Chang, PhD, Associate Director

National Cancer Institute Graça M. Dores, MD, MPH, Associate Director

National Institutes of Health Susan N. Perkins, PhD, Associate Director

EPN, Suite 321, MSC 7361 Stephen D. Hursting, PhD, MPH, RD, Special
Guest

6130 Executive Boulevard Susan Winer, Program Specialist

Bethesda, Maryland 20892-7361 Trishna Dey, Program Coordinator

Telephone: 301-496-8640 Lisa Poe, Program Assistant

Fax: 301-402-4863 Gwendolyn Green, Administrative Assistant

http://cancer.gov/prevention/pob Bethany Vaughn, Summer Intern

**Educational Objective**

The overall objective of the course is to provide specialized
instruction in principles of molecular biology as applied in the field
of cancer prevention. The course focuses on the concepts, methods,
issues, and applications of molecular biology in cancer prevention
efforts and genetics of cancer. Participants will have an opportunity to
gain a broad-based perspective of these subject areas, including basic
laboratory methodology and theory of how molecular techniques are
applied to molecular epidemiology, bionutrition, chemoprevention,
biomarkers, and translational research. Life-long learning skills
include critical appraisal of molecular approaches, methodologies, and
theories used in the field of cancer prevention.

The National Institutes of Health/Foundation for Advanced Education in
the Sciences (NIH/FAES) is accredited by the Accreditation Council for
Continuing Medical Education to provide continuing medical education for
physicians.

The target audiences are MD and PhD degree holders who also hold an MPH
degree, and were selected into the Cancer Prevention Fellowship Program,
and MD and PhD degree holders with an interest in cancer prevention and
control from the NIH and the NCI, national organizations, and foreign
institutions.

If you have a disability and require any assistive devices, services, or
other reasonable accommodations to participate in this activity, please
contact the Office of Preventive Oncology at 301-496-8640 at least 1
week in advance of the lecture date to discuss your needs.

NCI Summer Curriculum in Cancer Prevention and Control

Molecular Prevention Course

**Monday, August 1, 2005**

8:30 a.m. - 10:00 a.m. Introduction/Course Overview and Stephen
Hursting, PhD, MPH, RD

> Molecular Biology Primer

Break

10:30 a.m. - 12:00 noon Cancer From a Biosystem Perspective J. Carl
Barrett, PhD

Lunch

1:00 p.m. - 2:30 p.m. Oncogenes, Tumor Suppressor Genes, and Michael
Birrer, MD, PhD

> Other Cancer-Related Genes

### **Tuesday, August 2, 2005**

8:30 a.m. - 10:00 a.m. The Quest for New Molecular Targets for Patricia
Steeg, PhD

> Cancer Prevention and Treatment

Break

10:30 a.m. - 12:00 noon Xenobiotic Metabolism and Cancer Susceptibility
Thomas Kensler, PhD

Lunch

1:00 p.m. - 2:30 p.m. Transcription Factors as Targets for Cancer Nancy
Colburn, PhD

Prevention

### **Wednesday, August 3, 2005**

8:30 a.m. - 10:00 a.m. The Immune System as a Target for Vaccine John
Greiner, PhD

> and Prevention Approaches

Break

10:30 a.m. - 12:00 noon Hormonal Carcinogenesis Robin Fuchs-Young, PhD

Lunch

1:00 p.m. - 2:30 p.m. Inflammation and Methylation: Key Targets Asad
Umar, DVM, PhD

> for Chemoprevention

**[Thursday, August 4, 2005]{.underline}**

8:30 a.m. - 10:00 a.m. Animal Models for Cancer Prevention Studies
Jeffrey Green, MD

Break

10:30 a.m. - 12:00 noon New Approaches To Imaging Cancer Processes
Steven Libutti, MD

######## In Vivo

Lunch

1:00 p.m. - 2:30 p.m. Application of Genomics and Proteomics to Andrew
Feldman, MD

Cancer Research

### **Friday, August 5, 2005**

8:30 a.m. - 10:00 a.m. The Integration of Molecular Markers Into
Nathaniel Rothman, MD

> Population Studies I

Break

10:30 a.m. - 12:00 noon Molecular Epidemiology: The Integration of
Nathaniel Rothman, MD

> Molecular Markers Into Population Studies II
>
> Faculty

**J. Carl Barrett, PhD --** *Cancer From a Biosystem Perspective*

> Director, Novartis Institutes for Biomedical Research, 250
> Massachusetts Avenue, Suite 3A-203, Cambridge, MA 02139, 617-871-3700,
> carl.barrett@nivartis.com

**Michael Birrer, MD, PhD** **--** *Oncogenes, Tumor Suppressor Genes,
and Other Cancer-Related Genes*

> Principal Investigator, Cell and Cancer Biology Branch, Center for
> Cancer Research, National Cancer Institute, National Institutes of
> Health, Key West Center, Room 300, 9610 Medical Center Drive,
> Bethesda, MD 20892, 301-402-3128, ext. 311,
> [**birrerm@bprb.nci.nih.gov**](mailto:birrerm@bprb.nci.nih.gov)

**Nancy Colburn, PhD --** *Transcription Factors as Targets for Cancer
Prevention*

> Head, Gene Regulation Section, Laboratory Chief, Laboratory of Cancer
> Prevention, National Cancer Institute-Frederick, National Institutes
> of Health, Building 576, Room 101, Frederick, MD 21702

301-846-1342, [**colburn@ncifcrf.gov**](mailto:colburn@ncifcrf.gov)

**Andrew Feldman, MD** -- *Application of Genomics and Proteomics to
Cancer Research*

Clinical Fellow, Laboratory of Pathology, National Cancer Institute,
National Institutes of Health,

> Building 10, Room 2N202, 10 Center Drive, MSC 1750, Bethesda, MD
> 20892-1750, 301-402-8895,
> [**feldmana@dino.nci.nih.gov**](mailto:feldmana@dino.nci.nih.gov)

**Robin Fuchs-Young, PhD** -- *Hormonal Carcinogenesis*

> Assistant Professor of Carcinogenesis, Director, Community Outreach
> and, Education Program
>
> Science Park Research Division, The University of Texas M.D. Anderson
> Cancer Center, P.O. Box 389, Park Road 1C, Smithville, TX 78957,
> 512-237-9547,
> [**rofy@sprd1.mdacc.tmc.edu**](mailto:rofy@sprd1.mdacc.tmc.edu)

Jeffrey Green, MD -- *Animal Models for Cancer Prevention Studies*

> Senior Investigator, Center for Cancer Research, National Cancer
> Institute, National Institutes of Health, Building 41, Room C619,
> Bethesda, MD 20892, 301-435-5193,
> [**jg155c@nih.gov**](mailto:jg155c@nih.gov)

**John Greiner, PhD** -- *The Immune System as a Target for Vaccine*
*and Prevention Approaches*

> Section Chief, Laboratory of Tumor Immunology and Biology, Center for
> Cancer Research, National Cancer Institute, National Institutes of
> Health, Building 10, Room 8B04, 10 Center Drive, MSC 1750, Bethesda,
> MD 20892-1750, 301-496-9813,
> [**greinerj@mail.nih.gov**](mailto:greinerj@mail.nih.gov)

**Stephen Hursting, PhD, MPH** -- *Introduction/Course Overview and
Molecular Biology Primer*

> Professor and McKean-Love Chair of Molecular, Cellular and Nutritional
> Sciences, University of Texas-Austin, MD Anderson Cancer Center,
> Division of Nutritional Sciences, Department of Human Ecology, College
> of Natural Sciences, Gearing Hall 117, Austin, TX 78712, 512-471-4287

Thomas Kensler, PhD -- *Xenobiotic Metabolism and Cancer Susceptibility*

> Department of Environmental Health Sciences, The Johns Hopkins
> University Bloomberg School of Public Health, 615 N. Wolfe Street,
> Baltimore, MD 21205, 410-955-4712,
> [**tkensler@jhsph.edu**](mailto:tkensler@jhsph.edu)

**Steven K. Libutti, MD --** *New ApproachesTo Imaging Cancer Processes*
In Vivo

Principal Investigator, Surgery Branch, National Cancer Institute,
National Institutes of Health,

> Building 10, Room 4W-5940, 10 Center Drive, Bethesda, MD 20892,
> 301-496-5049, <steven_libutti@nih.gov>

**Nathaniel Rothman, MD** -- *The Integration of Molecular Markers Into
Population Studies I*

######### Molecular Epidemiology: The Integration of Molecular Markers Into 

> *Population Studies* II
>
> Senior Investigator, Occupational Epidemiology Branch, Division of
> Cancer Epidemiology and Genetics, National Cancer Institute, National
> Institutes of Health, Executive Plaza South, Room 8116, 6120 Executive
> Boulevard, Bethesda, MD 20892, 301-496-9093,
> [**rothmann@mail.nih.gov**](mailto:rothmann@mail.nih.gov)

**Patricia S. Steeg, PhD** -- *The Quest for New Molecular Targets for
Cancer Prevention and Treatment*

> Chief, Women's Cancer Section, Laboratory of Pathology, Center for
> Cancer Research, Co-Chairperson, Molecular Targets Faculty, National
> Cancer Institute, National Institutes of Health, Building 10, Room
> 2A33, Bethesda, MD 20892, 301-402-2732,
> [**steegp@mail.nih.gov**](mailto:steegp@mail.nih.gov)

**Asad Umar, DVM, PhD** -- *Inflammation and Methylation: Key Targets
for Chemoprevention*

> Program Director/Expert, Gastrointestional and Other Cancer Research
> Group, National Cancer Institute, National Institutes of Health,
> Executive Plaza North, Room 2143, 6130 Executive Boulevard, MSC 7317,
> Bethesda, MD 20892-7317, 301-594-7671,
> [**umara@mail.nih.gov**](mailto:umara@mail.nih.gov)