![](media/image1.png){width="1.8118055555555554in"
height="1.8118055555555554in"}

+--------------------+-------------------------------------------------+
|                    | **MEDLARS Management Section**                  |
|                    |                                                 |
|                    | **U.S. National Library of Medicine^®^**        |
|                    |                                                 |
|                    | **National Institutes of Health**               |
|                    |                                                 |
|                    | **Department of Health and Human Services**     |
|                    |                                                 |
|                    | **Bethesda, Maryland**                          |
+--------------------+-------------------------------------------------+
|                    |                                                 |
+--------------------+-------------------------------------------------+
|                    |                                                 |
+--------------------+-------------------------------------------------+
|                    | **September 2008 Revision**                     |
+--------------------+-------------------------------------------------+

**[N]{.underline} [O]{.underline} [T]{.underline} [E]{.underline}
[S]{.underline}**

**NLM Training: NLM Gateway & ClinicalTrials.gov**

# Table of Contents {#table-of-contents .GatewayH1}

#  {#section .GatewayH1}

[Table of Contents i](#table-of-contents)

[Introduction to Gateway 1](#introduction-to-gateway)

[Boolean Operators 3](#boolean-operators)

[Searching by Fields 3](#searching-by-fields)

[Search Results 7](#search-results)

[Results Summary 7](#results-summary)

[Results Display 8](#results-display)

[E-mail 10](#e-mail)

[Download 11](#download)

[Put in Locker 11](#put-in-locker)

[Order Documents 12](#order-documents)

[Gateway Sidebar 13](#gateway-sidebar)

[Practice Exercises 15](#practice-exercises)

[Features 27](#features)

[Term Finder 27](#term-finder)

[Limits/Settings 30](#limitssettings)

[Search Details 34](#search-details)

[History 35](#history)

[My Locker 36](#my-locker)

[Practice Exercises 39](#practice-exercises-1)

[About ClinicalTrials.gov 49](#about-clinicaltrials.gov)

[Menu & Search bar 50](#menu-search-bar)

[The Footnote 50](#the-footnote)

[ClinicalTrials.gov Home Page 51](#clinicaltrials.gov-home-page)

[Resources 51](#resources)

[Investigator Instructions 51](#investigator-instructions)

[Background Information 51](#background-information)

[Search for Clinical Trials 52](#search-for-clinical-trials)

[Basic Search 52](#basic-search)

[Working with Results 52](#working-with-results)

[Display Options Menu 57](#display-options-menu)

[Advanced Search 58](#advanced-search)

[Studies by Topic 59](#studies-by-topic)

[Studies on Map 61](#studies-on-map)

[Refining your Search 63](#__RefHeading___Toc210448711)

[Refine Search 64](#refine-search)

[Results by Topic 66](#results-by-topic)

[Results on Map 70](#results-on-map)

[ClinicalTrials.gov Identifier Number & PubMed
72](#clinicaltrials.gov-identifier-number-pubmed)

[Practice Exercises 73](#__RefHeading___Toc210448716)

**[N]{.underline} [O]{.underline} [T]{.underline} [E]{.underline}
[S]{.underline}**

**NLM Training: NLM Gateway & ClinicalTrials.gov**

+--------------------+-------------------------------------------------+
| # Agenda           |                                                 |
+--------------------+-------------------------------------------------+
|                    |                                                 |
+--------------------+-------------------------------------------------+
| 8:30 -- 8:45       | > **Welcome**                                   |
+--------------------+-------------------------------------------------+
|                    |                                                 |
+--------------------+-------------------------------------------------+
| 8:45 -- 10:00      | > **NLM Gateway**                               |
+--------------------+-------------------------------------------------+
|                    | > Background                                    |
+--------------------+-------------------------------------------------+
|                    | > Searching                                     |
+--------------------+-------------------------------------------------+
|                    | > Functions                                     |
+--------------------+-------------------------------------------------+
|                    | > Download/Display                              |
|                    | >                                               |
|                    | > Send via e-mail                               |
+--------------------+-------------------------------------------------+
|                    | > Order documents                               |
+--------------------+-------------------------------------------------+
|                    | > Practice Exercises                            |
+--------------------+-------------------------------------------------+
| 10:00 -- 10:15     | > BREAK                                         |
+--------------------+-------------------------------------------------+
| 10:15 -- 11:00     | > Features                                      |
+--------------------+-------------------------------------------------+
|                    | > Term Finder                                   |
+--------------------+-------------------------------------------------+
|                    | > Limits/Settings                               |
|                    | >                                               |
|                    | > Search Details                                |
+--------------------+-------------------------------------------------+
|                    | > History                                       |
+--------------------+-------------------------------------------------+
|                    | > Locker                                        |
+--------------------+-------------------------------------------------+
|                    | > Practice Exercises                            |
+--------------------+-------------------------------------------------+
|                    |                                                 |
+--------------------+-------------------------------------------------+
| 11:00 -- 12:00     | > **ClinicalTrials.gov**                        |
+--------------------+-------------------------------------------------+
|                    | > Basic Search                                  |
+--------------------+-------------------------------------------------+
|                    | > Working with Results                          |
+--------------------+-------------------------------------------------+
|                    | > Display Options Menu                          |
+--------------------+-------------------------------------------------+
|                    | > Advanced Search                               |
+--------------------+-------------------------------------------------+
|                    | > Studies by Topic                              |
|                    | >                                               |
|                    | > Studies by Map                                |
|                    | >                                               |
|                    | > Refining your Search                          |
|                    | >                                               |
|                    | > ClinicalTrials.gov & PubMed                   |
+--------------------+-------------------------------------------------+
|                    | > Practice Exercises                            |
+--------------------+-------------------------------------------------+
|                    |                                                 |
+--------------------+-------------------------------------------------+

**[N]{.underline} [O]{.underline} [T]{.underline} [E]{.underline}
[S]{.underline}**

![](media/image2.png){width="6.418055555555555in"
height="0.6763888888888889in"}

**([http://gateway.nlm.nih.gov](http://gateway.nlm.nih.gov/))**

# Introduction to Gateway {#introduction-to-gateway .GatewayH1}

***What**?*

-   The NLM Gateway allows you to search simultaneously in multiple NLM
    retrieval systems using a single search interface.

-   The Gateway was developed by the Lister Hill National Center for
    Biomedical Communications (LHNCBC) at the National Library of
    Medicine (NLM).

-   Currently the Gateway searches:

+-------------------------------+--------------------------------------+
| -   **MEDLINE/PubMed**        | -   **ClinicalTrials.gov**           |
|                               |                                      |
| -   **TOXLINE Subset**        | -   **Genetics Home Reference**      |
|                               |                                      |
| -   **NLM Catalog**           | -   **DIRLINE:** Directory of Health |
|                               |     Organizations                    |
| -   **Bookshelf--** full text |                                      |
|     biomedical books          | -   **HSRProj:** Health Services     |
|                               |     Research Projects                |
| -   **DART:** Developmental   |                                      |
|     and Reproductive          | -   **OMIM:** Online Mendelian       |
|     Toxicology                |     Inheritance in Man               |
|                               |                                      |
| -   **Meeting Abstracts:**    | -   **IRIS**: Integrated Risk        |
|                               |     Information System               |
| HIV/AIDS-related, Health      |                                      |
| Services                      | -   **HSDB**: Hazardous Substances   |
|                               |     Data Bank                        |
| Research-related, and Space   |                                      |
| Life                          | -   **ITER:** International Toxicity |
|                               |     Estimates for Risk               |
| Sciences                      |                                      |
|                               | -   **GENE-TOX:** Genetic Toxicology |
| -   **MedlinePlus:**          |        Mutagenicity                  |
|                               |                                      |
| > **Health Topics**           | -   **CCRIS:** Chemical              |
| >                             |     Carcinogenesis Research          |
| > **Drug Information**        |     Information System               |
| >                             |                                      |
| > **Medical Encyclopedia**    | -   **Profiles in Science:**         |
| >                             |     Archival collections of          |
| > **Current Health News**     |     Scientists                       |
| >                             |                                      |
| > **Other Resources**         |                                      |
|                               |                                      |
| -   **Household Products      |                                      |
|     Database**                |                                      |
+-------------------------------+--------------------------------------+

-   NLM Gateway is the *only* search interface for the Meeting
    Abstracts.

-   Other systems (PubMed, NLM Catalog*,* MedlinePlus) retain their own
    search interfaces.

***Who?***

Potential Gateway users could be:

-   Users new to NLM's online resources who do not know what type of
    information is available or how best to search for it.

-   Users who want \"one-stop searching.\"

-   Users who want to search resources that are only in the NLM Gateway.

***Where?***

-   On the NLM home page, click on List of NLM Databases and Resources.
    At the next screen, click on NLM Gateway. Or go directly to:
    **[http://gateway.nlm.nih.gov](http://gateway.nlm.nih.gov/)**

**Gateway Homepage**

Beneath the Gateway banner is the Features Bar. On this bar are links to
two (2) Gateway Features, **Term Finder** and **Limits/Settings,** and
to information about the NLM Gateway

and its use: **About Help FAQ.**

In the center of the page is the search query box.

![](media/image3.png){width="6.347916666666666in"
height="2.717361111111111in"}

**Searching**

-   Enter the search term(s) in the query box.

-   Click on "Search" or use the Enter key.

  ----------------------------------------------------- -----------------------------------------------------------
  ![](media/image4.jpeg){width="0.6145833333333334in"   The query box is also available on every screen below the
  height="0.6666666666666666in"}                        features bar. You do not have to return to the homepage to
                                                        enter a new search.

  ----------------------------------------------------- -----------------------------------------------------------

## 

**Searching Tips**

There are links under the query box to tips on searching by topics,
authors, and titles and about searching meeting abstracts. Additional
helpful points to know:

-   The default Gateway search is a subject search.

-   You may enter one or more terms in the query box.

> **Example:** *vitamins*
>
> *vitamin c aged*
>
> *vitamin c aged common cold*

-   Multi-word search terms are searched as phrases when Gateway's
    Phrase Detection function identifies them as such.

-   Search terms are mapped to MeSH (Medical Subject Headings) terms.
    For example, if your search term is heart attack, the phrase is
    mapped to myocardial infarction. Myocardial infarction is searched
    as a MeSH term in addition to heart attack being searched as text
    word. This mapping helps to provide more comprehensive results.

```{=html}
<!-- -->
```
-   For terms with British and American spellings, the text word search
    will include both the British and the American spelling of the word.

```{=html}
<!-- -->
```
-   Search terms are automatically combined (ANDed) together.

## Boolean Operators {#boolean-operators .GatewayH2}

-   Use AND, OR, and NOT.

-   The default Boolean operator is AND.

-   Boolean operators AND, OR, and NOT must be in upper case (e.g.,
    vitamin c OR zinc).

-   The Gateway processes the AND and OR Boolean operators in a
    left-to-right sequence.

-   The NOT operator is processed first.

-   Nesting: You can change the order in which the Gateway processes the
    AND and OR operators in a search statement by enclosing the unit in
    parentheses. The terms inside the set of parentheses will be
    processed as a unit and then incorporated in the overall strategy.

> **Examples:** w*rinkles AND (vitamin e OR vitamin c) *

*hay fever AND (claritin OR zyrtec)*

## Searching by Fields {#searching-by-fields .GatewayH2}

-   Searches can be refined using qualifiers to limit the search to
    specific field(s).

-   All field qualifiers should be entered *after* the search term.

> **Example:** *spanish \[la\]*

-   Field qualifiers may be in upper or lower case and must be in square
    brackets.

-   Qualifiers may be the search field label (i.e., \[**Language**\]) or
    abbreviation/tag (i.e., \[**LA**\])

-   **N.B.:** Unqualified terms should be entered after all qualified
    terms or should be separated with a Boolean operator (AND, OR, NOT).

> **Examples:** *lead screening \[ti\] children*
>
> *common cold AND vitamin c \[mh\]*

+----------+-----------------------------------------------------------+
| ![]      | The Gateway's **Help** lists all allowable search fields  |
| (media/i | for every collection                                      |
| mage4.jp |                                                           |
| eg){widt | And their abbreviations.                                  |
| h="0.677 |                                                           |
| 08333333 |                                                           |
| 33334in" |                                                           |
| height   |                                                           |
| ="0.7291 |                                                           |
| 66666666 |                                                           |
| 6666in"} |                                                           |
+----------+-----------------------------------------------------------+

**Author Name Searching**

-   Enter the author name in the format last name plus initials (no
    punctuation), followed by the field qualifier (\[au\] or
    \[author\]). Suffixes may be included if known.

> **Examples:** *harris mj \[au\]*

*ferris f 3rd \[author\]*

-   You may enter only the last name or the last name and the first
    initial if you do not know the middle initial.

> **Example: c***harron-prochownik d \[au\] AND siminerio \[au\]*

The Gateway will truncate an author search for MEDLINE/PubMed, NLM
Catalog, Meeting

Abstracts, HSRProj, OMIM, and TOXLINE Subset. There is no author field
in the other

collections.

**[Note:]{.underline}**

> You may search for investigators in **HSRProj** and **NLM Catalog**
> collections using the author field qualifier. Investigator names in
> the HSRProj collection are displayed as full names but must be
> searched in the format last name plus initials (no punctuation).

**Corporate Author Searching**

-   To search for a particular corporate author, enter the corporate
    author followed by the field qualifier \[cn\].

-   You may search for multiple corporate authors at one time.

**Examples**:

*international society of technology assessment in health care meeting
\[cn\]*

*cochrane colloquium \[cn\]*

*conference on retroviruses and opportunistic infections \[cn\] AND hiv
outpatient study \[cn\]*

> *international conference on aids \[cn\] AND 2000 \[dp\]*

+--------------+-------------------------------------------------------+
| ![           | Drop parentheses from corporate author names that     |
| ](media/imag | contain them.                                         |
| e5.png){widt |                                                       |
| h="0.8125in" | **Example:** International Conference on AIDS (15th : |
| height       | 2004 : Bangkok, Thailand)                             |
| ="0.80138888 |                                                       |
| 88888889in"} | Enter as: international conference on aids 15th :     |
|              | 2004 : bangkok, thailand \[cn\]                       |
+--------------+-------------------------------------------------------+

**Title Searching**

-   Enter one or more title words followed by the field qualifier
    (\[ti\] or \[title\]).

**Examples:**

*aids \[title\] sexually transmitted diseases \[title\]*

*lyme disease \[ti\]*

*quality of life \[title\]*

*managed care \[ti\] quality \[ti\]*

**MeSH Searching**

-   Enter the MeSH term followed by the field qualifier (\[mh\] or
    \[mesh\]).

-   Subheadings may be entered in full or the two-character abbreviation
    may be used.

-   To search for a MeSH term with one or more subheadings, enter the
    MeSH term, a forward slash, and one or more subheadings, followed by
    the field qualifier

(e.g., \[mesh\]).

-   If multiple subheadings are entered for one MeSH term, the
    subheadings will be ORed together (e.g., myocardial infarction/su/dt
    \[mh\] is equivalent to myocardial infarction/su \[mh\] OR
    myocardial infarction/dt \[mh\]).

> **Examples:**

*melanoma \[mh\]*

> *lyme disease \[mh\]*

*macular degeneration/therapy \[mesh\]*

*knee injuries/di/co \[mh\]*

-   Explosions: If a MeSH term or MeSH major topic is entered, it will
    be automatically exploded only in PubMed/MEDLINE and NLM Catalog.

```{=html}
<!-- -->
```
-   To turn off automatic explosion, enter the MeSH field qualifier
    followed by \":noexp\" (e.g., \[mh:noexp\])

-   For other collections, MeSH terms are not exploded.

## Spell Check 

Gateway processes search terms through a spell checker. If a spelling
error is found, Gateway displays a notice.

![](media/image6.png){width="3.5409722222222224in" height="0.46875in"}

**[Details]{.underline}** of the Spell Check reports the term(s) entered
incorrectly and offers suggested corrections.

![](media/image7.png){width="5.5in" height="2.9791666666666665in"}

# Search Results {#search-results .GatewayH1}

## Results Summary {#results-summary .GatewayH2}

> When the search is completed, the Gateway displays the Results
> Summary: the number of **Items Found** in each collection.

**Results Summary for "hay fever" search:**

![](media/image8.png){width="6.479166666666667in"
height="3.686111111111111in"}

To display the results for a collection, click on the collection
**name** or **number** of results.

## Results Display {#results-display .GatewayH2}

**Example:** *Results for PubMed*

Navigating: Use **[Next]{.underline}** and **[Prev]{.underline}**ious
arrows or fill in a page number & click **[Page]{.underline}** to jump
to it.

![](media/image9.png){width="6.405555555555556in" height="5.03125in"}

[Related Articles]{.underline} takes you to a set of citations closely
related to the selected article.

[Free at producer
site](http://www.pubmedcentral.gov/articlerender.fcgi?tool=gateway&pubmedid=11509422)
links to the full-text article at the producer's web site.

[Free in
PMC](http://www.pubmedcentral.gov/articlerender.fcgi?tool=gateway&pubmedid=11509422)
links to the full-text article in PubMed Central.

Clicking on a title displays an expanded or fuller view of the item.

![](media/image10.png){width="6.218055555555556in"
height="8.055555555555555in"}

**Gateway Functions**

**[E-mail]{.underline} \| [Download]{.underline} \| [Put in
locker]{.underline}**

The Functions are at the top and bottom of each Results Page. The added
function of [Order documents]{.underline}

is available for PubMed results. Use the check boxes to select the items
for a function to process. If none are selected, all on the page will be
processed\... Use [Clear check marks]{.underline} to deselect.

![](media/image11.png){width="5.978472222222222in"
height="1.9680555555555554in"}

###  {#section-2 .GatewayH3}

### E-mail {#e-mail .GatewayH3}

-   On the Results display, select items you wish to e-mail. (Use check
    boxes to select items)

-   Click on **E-mail.** The Send via E-mail page displays.

![](media/image12.png){width="5.218055555555556in"
height="2.6444444444444444in"}

-   Use the **Starting with item** pull-down menu to select the number
    of items to download or display. The maximum number of items for
    downloading/displaying at one time is 500.

-   Use the **Details** pull-down menu to select the display content.
    Choices are Brief, Expanded, and Complete. The default details is
    Brief.

-   Use the **Format** pull-down menu to select the format: the default
    Format is Unlabelled.

Labelled = labels each field with the full field name.

> Export = labels each field with the field name abbreviation. The
> Export format is used for importing data into bibliographic management
> programs.

-   Use the **Send as** pull-down menu to select Text or Html. The
    default is Text.

-   Enter an e-mail address in the box provided. An accompanying message
    may be entered in its designated box.

-   Click **Send**.

> The email address is verified and you are notified that the data was
> successfully sent or when an error in the address causes the e-mail
> delivery to fail. The latter enables the user to correct the address
> and ensure delivery of the e-mail.

**[E-mail sent to : person@mail.nih.gov]{.mark}**

### Download {#download .GatewayH3}

Use **Download** to Display multiple items in the Web browser or Save
items to a file.

-   On the Results display, select items you wish to download or display
    further.

-   Click on **Download**.

-   Make your selections from the Download or Display screen.

> **[Note]{.underline}**: the top five lines of the Download or Display
> page are the same as those on the
>
> Send via E-mail page.

![](media/image13.png){width="5.800694444444445in"
height="2.270138888888889in"}

After selecting the **Starting with item**, the **Details**, and the
**Format,**

-   use the **Destination** pull-down menu to select the destination for
    the items to be downloaded or displayed. Choices are

Display in Browser

Display for Printing

Save to File.

The default destination is Display in Browser.

-   Use the **Download as** pull-down menu to select Text or Html. The
    default is Text.

-   Click **Go**.

###  {#section-3 .GatewayH3}

###  {#section-4 .GatewayH3}

### Put in Locker {#put-in-locker .GatewayH3}

This function enables you to store items. **My Locker** is a place to
collect selected search items for printing, downloading, e-mailing or
ordering. For details on using the locker, see **My Locker** in the
Features section (p. 36).

### Order Documents  {#order-documents .GatewayH3}

To order items from PubMed results of your [current search]{.underline},
select the Order Documents function. Order Documents enables you to
order documents directly from the Results Display page.

-   **Please note that items may only be ordered from PubMed**

-   On the Results display, select citations you wish to order.

-   Click on **Order Documents**.

-   The Gateway Document Ordering page will be displayed, containing
    your selected items.

> [Note]{.underline}: articles that have Free full text in PubMed
> Central or at the producer's web site
>
> are flagged with a link to the full-text and do not need to be
> ordered.

![](media/image14.png){width="6.450694444444444in"
height="4.061805555555556in"}

## 

-   Review your choices.

> \[Note: for Free full text, you may go to the articles in PubMed
> Central or the producer's site at this time or later. To continue with
> the ordering process for the other articles: Return to the selections
> on the Results Display and "uncheck" those that are Free in PubMed
> Central. Click \"Order Documents\" on the display page once more\].

-   Click the \"Order Documents\" button on the Ordering Page.

-   The Loansome Doc Ordering page will open in a separate browser
    window.

-   You can also order documents through My Locker and its 'Order
    Documents' function. (See the section on My Locker.)

## Gateway Sidebar {#gateway-sidebar .GatewayH2}

On the left side of each page displaying a collection's results is a
list of all of the collections that Gateway searches and the number of
results found in each for the current search. Click on a collection to
go directly to the 1^st^ results page of that collection.

**Example:** *Click on NLM Catalog to view the results from that
collection.*

  ----------------------------------------------------- -----------------------------------------------------
  ![](media/image15.png){width="1.4590277777777778in"   ![](media/image16.png){width="5.001388888888889in"
  height="6.206944444444445in"}                         height="6.218055555555556in"}

  ----------------------------------------------------- -----------------------------------------------------

Click **Bookmark this search** to save the search strategy. Then click
**Create storable search page.** A new browser window will open with the
Results Summary page for the search. Use the browser's Bookmarks or
Favorites feature to save the search. Then close the browser window. Use
the browser's Back button to return to the previous page.

Click on **Results** on the sidebar to go to the Results Summary Page.

**[N]{.underline} [O]{.underline} [T]{.underline} [E]{.underline}
[S]{.underline}**

# Practice Exercises {#practice-exercises .GatewayH1}

1.  Locate information on acupuncture and arthritis. How many clinical
    trials are currently recruiting volunteers (i.e., "Status:
    Recruiting")?

2.  Locate information on alternative medicine and back pain. Review
    abstracts from papers presented at meetings. Identify the earliest
    paper. What organization held the meeting at which it was presented?

3.  Find organizations where I can obtain information about Sleep Apnea.
    How many were retrieved?

4.  Find information in the German language that discusses liver cancer.
    \[Remember: Gateway supports Searching by Fields\] Select several
    NLM Catalog results and, using a Gateway function, display the
    selected items in the Expanded and Labelled format.

5.  Search on Agent Orange. How many articles are found in TOXLINE
    Subset? Send 10 articles to your email address. Add a
    message/comment and signature to your email.

6.  Are there any items by Michael E. DeBakey in NLM Catalog? Are there
    any videorecordings about surgery? What type of surgery is the
    topic?

7.  Search photic sneeze reflex. From citations or genetic information
    (i.e., OMIM collection) determine the syndrome name by which it is
    known.

8.  Search for information about genetics and testing of newborns. From
    the Results:

Locate information in Genetics Home Reference about types of tests done
in the United

States. What are the 2 disorders all states test for?

In Bookshelf, select the National Library of Medicine's HSTAT
publication. What 2 diseases

are discussed?

What former Johns Hopkins lecturer in medical genetics impacted newborn
testing world-wide?

(Hint: see NLM's archival collection, Profiles in Science)

What assessment method is their legacy?

**Suggested Answers**

1.  Locate information on acupuncture and arthritis. How many clinical
    trials are currently recruiting volunteers (i.e., "Status:
    Recruiting")?

***Step 1.*** Type the search terms in the query box. Use the Enter key
or click on the **Search** button.

![](media/image17.png){width="4.789583333333334in"
height="2.071527777777778in"}

***Step 2.*** Display Results for ClinicalTrials.gov. Note those that
are currently recruiting.

![](media/image18.png){width="5.426388888888889in"
height="4.082638888888889in"}

2\. .Locate information on alternative medicine and back pain. Review
abstracts from papers presented at meetings. Identify the earliest
paper. What organization held the meeting at which it was presented?

***Step 1:*** Type the search terms in the query box. Use the Enter key
or click on the **Search** button.

![](media/image19.png){width="4.426388888888889in" height="0.625in"}

***Step 2:*** Display Results for Meeting Abstracts. Note name of
organization.

![](media/image20.png){width="6.445138888888889in" height="4.21875in"}

3\. Find organizations where I can obtain information about Sleep Apnea.
How many

> were retrieved?

***Step 1:*** Type the search terms in the query box. Use the Enter key
or click on the **Search** button.

![](media/image21.png){width="5.030555555555556in" height="0.53125in"}

***Step 2:*** Note number of results for DIRLINE - Directory of Health
Organizations.

![](media/image22.png){width="6.465972222222222in"
height="4.948611111111111in"}

4\. Find information in the German language that discusses liver cancer.
\[Remember: Gateway supports Searching by Fields\] Select several NLM
Catalog results and, using a Gateway function, display the selected
items in the Expanded and Labelled format.

***Step 1:*** Type the search terms in the query box, qualifying German
by Language \[la\].

(Note: you can use the full name of the language or the 3-letter code,
e.g., ger) Use the Enter key or click on the **Search** button.

![](media/image23.png){width="5.009722222222222in"
height="0.4895833333333333in"}

OR

![](media/image24.png){width="4.926388888888889in"
height="0.4791666666666667in"}

***Step 2.*** Select NLM Catalog results.

![](media/image25.png){width="2.6354166666666665in"
height="2.3020833333333335in"}

***Step 3:*** Choose several results from NLM Catalog. Select the
**Download** function.

(*Note check marks*)

![](media/image26.png){width="5.548611111111111in" height="2.75in"}

***Step 4:*** Select **Expanded** Details and **Labelled** Format. Click
**Go.**

![](media/image27.png){width="4.311805555555556in"
height="3.1243055555555554in"}

***Step 5:*** View displayed records.

![](media/image28.png){width="5.322222222222222in"
height="3.2909722222222224in"}

5\. Search on Agent Orange. How many articles are found in TOXLINE
Subset? Send 10

> articles to your email address. Add a message/comment and signature to
> your email.

***Step 1:*** Type the search terms in the query box. Use the Enter key
or click on the **Search** button.

Display results for TOXLINE Subset. Select 10 citations. Click the
**E-mail** Function.

![](media/image29.png){width="5.509722222222222in"
height="4.207638888888889in"}

***Step 2:*** Enter E-mail address and message. Click **Send**.

![](media/image30.png){width="4.645138888888889in"
height="3.0520833333333335in"}

6\. Are there any items by Michael E. DeBakey in NLM Catalog? Are there
any videorecordings about surgery? What type of surgery is the topic?

***Step 1:*** Type the search in the query box, using the 'author' field
qualifier \[author\] or \[au\]. Use the Enter key or click on the
**Search** button

![](media/image31.png){width="4.374305555555556in" height="0.46875in"}

***Step 2:*** Display results for NLM Catalog.

![](media/image32.png){width="6.374305555555556in"
height="6.051388888888889in"}

> 7\. Search photic sneeze reflex. From citations or genetic information
> (i.e., OMIM collection) determine the syndrome name by which it is
> known.

***Step 1:*** Type the search terms in the query box. Use the Enter key
or click on the **Search** button. For citations, display PubMed
results. Use sidebar to go to OMIM results.

![](media/image33.png){width="6.458333333333333in"
height="4.039583333333334in"}

***Step 2:*** Note syndrome name in displayed OMIM results.

![](media/image34.png){width="4.988888888888889in"
height="2.8118055555555554in"}

#  {#section-6 .GatewayH1}

9.  Search for information about genetics and testing of newborns.
    Locate information in Genetics Home Reference about types of tests
    done in the United States. What are the 2 genetic disorders all
    states test for?

In Bookshelf, select the National Library of Medicine's HSTAT
publication. What 2 diseases

are discussed?

What former Johns Hopkins lecturer in medical genetics impacted newborn
testing world-wide?

(Hint: see NLM's archival collection, Profiles in Science)

> What assessment method is their legacy?

***Step 1.*** Enter the search terms in the query box. Use the Enter key
or click on the **Search** button. Display Genetics Home Reference
results. Click on a relevant link.

![](media/image35.png){width="4.915972222222222in"
height="2.1979166666666665in"}

***Step 2.*** Note the 2 disorders all states currently test infants
for.

![](media/image36.png){width="6.475694444444445in"
height="3.563888888888889in"}

***Step 3.*** Close Genetics Home Reference page. Use sidebar on the
Results Page to go to Bookshelf.

![](media/image37.png){width="6.165972222222222in"
height="2.3333333333333335in"}

> Display Bookshelf results and select the HSTAT publication.

![](media/image38.png){width="5.104861111111111in"
height="2.6152777777777776in"}

***Step 4.*** Note the 2 diseases discussed.

![](media/image39.png){width="5.436805555555556in" height="2.40625in"}

***Step 4.*** Close Bookshelf page. Use sidebar to go to Profiles in
Science results.

![](media/image40.png){width="1.5409722222222222in"
height="2.823611111111111in"}

Click on link in the Profiles in Science results.

![](media/image41.png){width="4.843055555555556in"
height="1.7083333333333333in"}

![](media/image42.png){width="6.34375in" height="3.2381944444444444in"}

#   {#section-7 .GatewayH1}

# Features {#features .GatewayH1}

**Gateway's *Features* enhance and/or refine search and display
operations.**

**The *Features Bar* is located under the banner.**

![](media/image43.png){width="6.498611111111111in"
height="1.229861111111111in"}

## Term Finder {#term-finder .GatewayH2}

-   Use Term Finder to select search terms from the MeSH vocabulary and
    the Unified Medical Language System (UMLS) metathesaurus.

-   Click on **Term Finder** on the Features Bar.

On the initial **Term Finder** screen, type the term you want to find,
e.g., **shingles**.

![](media/image44.png){width="6.218055555555556in"
height="3.145138888888889in"}

**After clicking on Go, you will see a graphic similar to that on the
next page.**

+-------------+--------------------------------------------------------+
| *Note the   | ![](media/image45.png){width="5.116666666666666in"     |
| d           | height="8.260416666666666in"}                          |
| efinition.* |                                                        |
|             |                                                        |
| *Click on   |                                                        |
| **Related   |                                                        |
| Concepts**  |                                                        |
| to see      |                                                        |
| other       |                                                        |
| related     |                                                        |
| terms.*     |                                                        |
|             |                                                        |
| *Click on   |                                                        |
| **View MeSH |                                                        |
| In          |                                                        |
| formation** |                                                        |
| for         |                                                        |
| additional  |                                                        |
| details     |                                                        |
| about the   |                                                        |
| term.*      |                                                        |
|             |                                                        |
| *Use the    |                                                        |
| **Add to    |                                                        |
| Search**    |                                                        |
| button and  |                                                        |
| the         |                                                        |
| **          |                                                        |
| Connector** |                                                        |
| pull-down   |                                                        |
| to add this |                                                        |
| term to     |                                                        |
| your search |                                                        |
| strategy.*  |                                                        |
|             |                                                        |
| *Use the    |                                                        |
| **Main      |                                                        |
| point of    |                                                        |
| item**      |                                                        |
| checkbox to |                                                        |
| limit the   |                                                        |
| term to the |                                                        |
| main point  |                                                        |
| of the      |                                                        |
| item.*      |                                                        |
|             |                                                        |
| *Use the    |                                                        |
| **Do not    |                                                        |
| explode     |                                                        |
| this term** |                                                        |
| checkbox to |                                                        |
| turn off    |                                                        |
| automatic   |                                                        |
| explosion   |                                                        |
| in PubMed   |                                                        |
| and NLM     |                                                        |
| Catalog.*   |                                                        |
|             |                                                        |
| *Click on   |                                                        |
| *           |                                                        |
| *Subheading |                                                        |
| De          |                                                        |
| finitions** |                                                        |
| if you need |                                                        |
| to check a  |                                                        |
| subheading  |                                                        |
| d           |                                                        |
| efinition.* |                                                        |
|             |                                                        |
| *Select     |                                                        |
| su          |                                                        |
| bheading(s) |                                                        |
| to attach   |                                                        |
| to your     |                                                        |
| term by     |                                                        |
| clicking on |                                                        |
| the         |                                                        |
| ch          |                                                        |
| eckbox(s).* |                                                        |
|             |                                                        |
| *Note the   |                                                        |
| MeSH        |                                                        |
| h           |                                                        |
| ierarchical |                                                        |
| tree        |                                                        |
| s           |                                                        |
| tructure(s) |                                                        |
| where the   |                                                        |
| term is     |                                                        |
| found.*     |                                                        |
+-------------+--------------------------------------------------------+

-   Adjust the 'shingles' search by selecting the subheading
    **complications.**

```{=html}
<!-- -->
```
-   Click on the **Add to Search** button. If there is no term already
    in the query box, the default connector **AND** will be ignored.

![](media/image46.png){width="5.404166666666667in"
height="4.000694444444444in"}

The selected term is entered in the search query box.

![](media/image47.png){width="5.645138888888889in"
height="2.0520833333333335in"}

Use the Enter key or click on the **Search** button to have the Gateway
run your search.

## Limits/Settings {#limitssettings .GatewayH2}

-   Enter your search term in the query box. Click on
    **Limits/Settings** on the Features Bar.

> [Customize your search by using **Search Limits:**]{.underline}

+---------------------------------------------------------------------+---+
| > ![](media/image48.png){width="5.978472222222222in"                |   |
| > height="3.0708333333333333in"}                                    |   |
+---------------------------------------------------------------------+---+

**English Only Limit**

-   Searching all languages is the default.

-   Click in the box to select English Only and limit your search to
    English language items only.

*This limit is ignored in the collections in Consumer Health Resources
and in the HSDB collection.*

## 

**Subsets**

-   Use the Subsets pulldown menu to select the subset to limit
    retrieval to particular items.

-   You may apply no subsets or one subset.

-   

![](media/image49.png){width="6.498611111111111in"
height="2.645138888888889in"}

**Publication Date Limit**

-   Searching all years is the default.

-   Use the from/to boxes to limit your search to specific publication
    dates.

-   One publication date or a date range may be searched.

-   A publication date or date range may be searched using the format
    YYYY/MM/DD (e.g., from 1998/02/02 to 2000/12/31). Months and days
    are optional and will be used only in searching PubMed. All other
    collections will be searched for the publication year only.

*This limit is ignored in Bookshelf, the Consumer Health Resources, and
in the HSDB, IRIS, ITER, GENE-TOX, CCRIS, and Profiles in Science
collections.*

-   Click on **Apply** to apply the selections only to your current
    Gateway session.

-   Click on **Save** to apply the selections to your current and future
    Gateway sessions.

-   Click on **Restore Default** to return settings for the selected
    Limits/Settings tab to the Gateway default settings.

-   Click on **Restore All Settings to Default** to return all settings
    to the Gateway default settings

To **Save** your settings, you are required to sign in with a User ID
and Password.

Registration is free.

![](media/image50.png){width="5.835416666666666in"
height="2.7069444444444444in"}

Gateway displays the verification: **User preferences saved.**

When you are signed in, use the Sign Out button that now appears on the
Features Bar to

exit your settings.

[Customize your results display by using **Results
Settings:**]{.underline}

-   Use the **Items per Page** pull-down menu to select the number of
    items displayed on the

> Results Display page.

![](media/image51.png){width="5.749305555555556in"
height="2.5729166666666665in"}

-   Use the " ... **Display Format**" pull-down menus to customize the
    display formats.

[Further customize your results display by using **Select
Fields:**]{.underline}

![](media/image52.png){width="6.290972222222222in"
height="3.2284722222222224in"}

Select a collection and click **Go.**

**The graphic on this page shows the HSRProj field selection screen.**

-   The check marks represent the default field selections for the Brief
    and Expanded display formats.

-   Add or remove check marks to customize the formats to display the
    fields you want to display.

![](media/image53.png){width="4.771527777777778in"
height="7.6930555555555555in"}

[Customize the settings for **Download/Display** and for e-mailing
results.]{.underline}

![](media/image54.png){width="5.603472222222222in"
height="3.7597222222222224in"}

## Search Details {#search-details .GatewayH2}

-   **Search Details** lets you view your search strategy as it was
    translated using the Gateway's automatic term mapping and search
    rules and syntax. Click Search Details on the Results Summary page
    and view the search strategies for all of the collections..

![](media/image55.png){width="5.022222222222222in" height="2.96875in"}

Clicking Search Details on the Results Display page of a collection
displays the search

strategy for that collection. There is also a link to Details of Search
for all of the collections.

-   **Details of Search** can also contain warning and error messages.
    If a search fails, check **Search Details.**

## History {#history .GatewayH2}

-   Click on **History** on the Features Bar to view your search
    history.

![](media/image56.png){width="6.445138888888889in"
height="2.8222222222222224in"}

-   Search strategies and results for as many as the last 25 searches
    will be displayed.

```{=html}
<!-- -->
```
-   Once the maximum number of searches (25) has been reached, Gateway
    will remove the

> oldest search from the History to add the most current search.

-   You can use the Search Number(s) in a subsequent search. You can
    build on a search by

> adding terms (e.g., #1 AND circulation)

-   You can also combine searches, using search numbers and Boolean
    operators

> (e.g., #1 AND #2).

-   Your Search History will be lost when you close your web browser.

## My Locker {#my-locker .GatewayH2}

-   **My Locker** is a place to collect selected search items for
    printing, downloading,

e-mailing or ordering.

**Marking and putting items in your Locker**

-   Perform a search and select a collection from the Results Summary.

-   In the Results Display, use the check boxes to select items you wish
    to store in your locker.

-   Click on **Put in locker**.

You must Sign in to use the Locker (unless you have already signed in to
'Save' your Limits/Settings). User ID and password is required.
Registration is free.

![](media/image50.png){width="6.491666666666666in"
height="3.4902777777777776in"}

> Note: you can elect to **Sign in** using your limits/settings.

-   Gateway confirms that the items have been added to your Locker.

![](media/image57.png){width="4.603472222222222in"
height="0.5833333333333334in"}

-   Click on **My Locker** on the Features Bar to see the contents of
    your Locker.

![](media/image58.png){width="5.520138888888889in"
height="4.093055555555556in"}

Note: the Sign Out button now appears on the Features Bar.

**Locker Tips:**

-   If an item is already in your locker, it will not be added again.

-   Contents of My Locker are grouped by collection.

-   Gateway functions are available in your locker.

-   Locker items remain until you delete them.

-   There is a limit of 500 items that may be stored in your locker.

**[N]{.underline} [O]{.underline} [T]{.underline} [E]{.underline}
[S]{.underline}**

# Practice Exercises {#practice-exercises-1 .GatewayH1}

1.  Search for information on breast cancer where tamoxifen is the
    treatment. How many meeting abstracts were retrieved? Select those
    related to cost-effectiveness and put them in your locker. (You will
    most likely need to create a User ID and Password) View the contents
    in your Locker.

2.  Delete term(s) in search query box.. Search for information about
    Food Allergies, using the Term Finder feature to find and use the
    correct MeSH term for your search query.

3.  Using Gateway's Limits feature, locate information published between
    2000 and 2004 on crystal methamphetamine and HIV. Is free full text
    of a journal article available online for any of the results? From
    what journal

4.  Delete term(s) in search query box, uncheck Limits under the query
    box, and customize the Brief format display for the HSRProj
    collection. Using the Limits/Settings feature, click on Select
    Fields tab to customize the Brief format display for HSRProj to
    include 2 fields: Project Status & Supporting Agency. Then, find the
    following information:

> Are there any ongoing health services research projects ('Project
> Status: Ongoing') on drug abuse treatment outcomes whose 'Supporting
> Agency' is National Institute on Drug Abuse (NIDA)?

5.  Using the History feature, re-search the search query for exercise
    #2 above, refining it by adding 'AND child' Are there any items in
    the NLM Catalog related specifically to toddlers?

**Suggested Answers**

1.  Search for articles on breast cancer where tamoxifen is the
    treatment. How many meeting abstracts were retrieved? Select those
    related to cost-effectiveness and put them in your locker. (You will
    most likely need to create a User ID and Password). View the
    contents in your Locker.

***Step 1:*** Type the search terms in the query box. Use the Enter key
or click on the **Search** button.

![](media/image59.png){width="4.363888888888889in"
height="0.4479166666666667in"}

***Step 2:*** Display the results for Meetings Abstracts. Select those
about cost-effectiveness.

Click on **Put in locker**.

![](media/image60.png){width="5.905555555555556in"
height="3.6555555555555554in"}

***Step 3:*** Sign into your Locker (You will most likely need to create
a User ID and Password)

![](media/image50.png){width="5.696527777777778in" height="3.0625in"}

***Step 4:*** Note: confirmation of number of items added to the Locker.
Click on **My Locker** on the

Features Bar to view the contents in your Locker.

![](media/image61.png){width="6.450694444444444in"
height="1.2708333333333333in"}

2\. Delete term(s) in search query box. Search for information about
Food Allergies, using the Term Finder feature to find and use the
correct MeSH term for your search query.

***Step 1:*** Delete term(s) in search query box. Click on **Term
Finder** on the features bar.

Type in the term and click the **Go** button to find the correct MeSH
term.

![](media/image62.png){width="6.415972222222222in"
height="2.532638888888889in"}

***Step 2:*** Click on **Add to Search** button to add the MeSH term for
Food Allergies in your

search query.

![](media/image63.png){width="6.435416666666667in"
height="2.6347222222222224in"}

***Step 3:*** Click on **Search** next to the search query box to run
your search.

![](media/image64.png){width="5.447222222222222in" height="0.78125in"}

3\. Using Gateway's Limits feature, locate information published between
2000 and 2004 on crystal methamphetamine and HIV. Is free full text of a
journal article available online for any of the results? From what
journal(s)?

***Step 1:*** Type the search terms in the query box. Click on
**Limits/Settings** on the features bar. On Search Limits tab, add
Publication Dates: \[from\] 2000 \[to\] 2004. Click on **Apply** to
apply the Limit to the current session. Click on **Search** next to the
search query box.

![](media/image65.png){width="6.103472222222222in"
height="4.103472222222222in"}

***Step 2.***: Display the results for MEDLINE/PubMed. Note link(s) to
Free full text.

Note journal's Title Abbreviation.

![](media/image66.png){width="6.435416666666667in"
height="4.165972222222222in"}

4.  Delete term(s) in search query box, uncheck Limits under the query
    box, and customize the Brief format display for the HSRProj
    collection. Using the Limits/Settings feature, click on Select
    Fields tab to customize the Brief format display for HSRProj to
    include 2 fields: Project Status & Supporting Agency.

> Then, find the following information:
>
> Are there any ongoing health services research projects ('Project
> Status: Ongoing') on drug abuse treatment outcomes whose 'Supporting
> Agency' is National Institute on Drug Abuse (NIDA)?

***Step 1:*** . Delete term(s) in search query box and uncheck Limits
under the query box.

Click on **Limits/Settings** on the features bar directly. Go to the
**Select Fields** tab.

Select **HSRProj** from the pull--down menu and click on **Go.**

![](media/image52.png){width="6.290972222222222in"
height="3.2284722222222224in"}

***Step 2:*** Add the 2 fields to the **Brief Format,** [Project
Status]{.underline} and [Supporting Agency]{.underline}.

> Click on **Apply.**

![](media/image67.png){width="5.035416666666666in"
height="3.191666666666667in"}

***Step 3:*** Type the search terms in the query box. Use the Enter key
or click on the **Search** button.

![](media/image68.png){width="4.353472222222222in"
height="0.4479166666666667in"}

***Step 4:*** View HSRProj results. Note items which have

> 'Supporting Agency: National Institute on Drug Abuse (NIDA)'
>
> 'Project Status: Ongoing'

![](media/image69.png){width="5.668055555555555in"
height="3.060416666666667in"}

5\. Using the History feature, re-search the search query for exercise
#2, refining it by adding 'AND child.' Are there any items in the NLM
Catalog related specifically to toddlers?

***Step 1:*** Click on **History** on the features bar. Enter **#2** in
the search query box. Add **AND child** to the query. Use the Enter key
or click on the **Search** button.

![](media/image70.png){width="6.470833333333333in"
height="2.8743055555555554in"}

***Step 2:*** Display the results for NLM Catalog. Note toddler-related
item(s).

![](media/image71.png){width="6.332638888888889in" height="3.83125in"}

**[N]{.underline} [O]{.underline} [T]{.underline} [E]{.underline}
[S]{.underline}**

![](media/image72.png){width="3.895138888888889in"
height="0.7395833333333334in"}

# About ClinicalTrials.gov {#about-clinicaltrials.gov .GatewayH1}

-   A clinical trial is a research study in human volunteers to answer
    specific health questions.

-   *Interventional trials* determine whether experimental treatments or
    new ways of using known therapies are safe and effective under
    controlled environments.

-   *Observational trials* address health issues in large groups of
    people or populations in natural settings.

-   ClinicalTrials.gov offers up-to-date information for locating
    federally and privately supported clinical trials for a wide range
    of diseases and conditions.

-   Studies listed in the database are conducted in 50 states and in
    over 150 countries.

-   ClinicalTrials.gov receives over 10 million page views per month and
    hosts approximately 30,000 visitors daily.

-   Available at **clinicaltrials.gov**; alternatively, from NLM's home
    page ([www.nlm.nih.gov](http://www.nlm.nih.gov/)), click on Health
    Information, and then click on the link to ClinicalTrials.gov from
    that page.

![](media/image73.png){width="6.449305555555555in"
height="0.6659722222222222in"}

## Menu & Search bar {#menu-search-bar .GatewayH2}

-   Appears as logo banner on all pages.

-   Facilitates navigation.

-   Search box provides an easy method to send a search from any page.

-   Click on **Home** to return to the home page of
    ClinicalTrials.gov*.*

-   **Search** returns to the Basic Search query page.

-   Use **Study Topics** to view studies in four main categories of
    Conditions, Drug Interventions, Sponsors, and Locations (discussed
    later in this workbook).

-   Use **Glossary** to become familiar with many of the common terms
    used in clinical trials.

## The Footnote {#the-footnote .GatewayH2}

![](media/image74.png){width="6.145138888888889in"
height="0.7916666666666666in"}

-   Click **U.S. National Library of Medicine** to reach NLM\'s home
    page.

-   Click **Contact NLM Customer Service** to send a customer service
    inquiry.

-   Click **U.S. National Institutes of Health** to reach its home page.

-   Click **U.S. Department of Health & Human Services** to reach its
    home page.

-   Click **USA.gov** to reach its home page.

-   Click **Copyright** to reach NLM's copyright information.

-   Click **Privacy** to reach NLM's privacy policy.

-   Click **Accessibility** to reach NLM's accessibility statement.

-   Click **Freedom of Information Act** (FOIA) to reach the NIH FOIA
    Office home page.

#  ClinicalTrials.gov Home Page {#clinicaltrials.gov-home-page .GatewayH1}

![](media/image75.png){width="6.435416666666667in"
height="4.425694444444445in"}

## Resources {#resources .GatewayH2}

Helpful information for patients and families

-   **Understanding Clinical Trials** in a question/answer format

-   **What's New** to view the most recently added trials

-   **Glossary** to become familiar with the most common terms used in
    clinical trials

## Investigator Instructions {#investigator-instructions .GatewayH2}

-   Links to the system for investigators/sponsors to register trials in
    ClinicalTrials.gov

##  {#section-9 .GatewayH2}

##  {#section-10 .GatewayH2}

## Background Information {#background-information .GatewayH2}

-   Resources links also included here

-   Links to Help; Glossary; and other consumer health-oriented
    resources

# Search for Clinical Trials {#search-for-clinical-trials .GatewayH1}

## Basic Search {#basic-search .GatewayH2}

-   Use **Basic Search** query box to find information broadly.

+--------+-------------------------------------------------------------+
| *Type  | ![](media/image76.png){width="5.540972222222222in"          |
| search | height="2.71875in"}                                         |
| t      |                                                             |
| erms.* |                                                             |
|        |                                                             |
| *Click |                                                             |
| **Se   |                                                             |
| arch** |                                                             |
| bu     |                                                             |
| tton.* |                                                             |
+--------+-------------------------------------------------------------+

  ----------------------------------------------------- ------------------------------------------------------------
  ![](media/image4.jpeg){width="0.8333333333333334in"   Some misspelled words can be recognized and suggestions are
  height="0.9166666666666666in"}                        provided through the automatic spell check feature.

  ----------------------------------------------------- ------------------------------------------------------------

## Working with Results {#working-with-results .GatewayH2}

##  {#section-11 .GatewayH2}

-   Results of your search are displayed under the **List Results** tab.

-   The current status of the trial (e.g., recruiting), title,
    condition(s), and interventions are shown for each clinical trial.

  ------------------------------------------------------ -----------------------------------------------------------
  ![](media/image77.jpeg){width="0.8645833333333334in"   The display default is for *all* trials. Click on the
  height="0.9263888888888889in"}                         **Hide studies which are not seeking new volunteers** link
                                                         to narrow your results to only studies recruiting new
                                                         volunteers (see example on next page).

  ------------------------------------------------------ -----------------------------------------------------------

**List Results (partial display):**

![](media/image78.png){width="6.479861111111111in"
height="4.354166666666667in"}

Click on the clinical trial title to see the full text view that may
include:

+--------+---------------------+------------------------------------+---+
| <      |                     |                                    |   |
| table> |                     |                                    |   |
| <col   |                     |                                    |   |
| group> |                     |                                    |   |
| <col   |                     |                                    |   |
| sty    |                     |                                    |   |
| le="wi |                     |                                    |   |
| dth: 5 |                     |                                    |   |
| 1%" /> |                     |                                    |   |
| <col   |                     |                                    |   |
| sty    |                     |                                    |   |
| le="wi |                     |                                    |   |
| dth: 4 |                     |                                    |   |
| 8%" /> |                     |                                    |   |
| </col  |                     |                                    |   |
| group> |                     |                                    |   |
| <      |                     |                                    |   |
| tbody> |                     |                                    |   |
| <tr    |                     |                                    |   |
| class= |                     |                                    |   |
| "odd"> |                     |                                    |   |
| <t     |                     |                                    |   |
| d><ul> |                     |                                    |   |
| <li><p |                     |                                    |   |
| >Brief |                     |                                    |   |
| Ti     |                     |                                    |   |
| tle</p |                     |                                    |   |
| ></li> |                     |                                    |   |
| </ul   |                     |                                    |   |
| ></td> |                     |                                    |   |
| <t     |                     |                                    |   |
| d><ul> |                     |                                    |   |
| <li    |                     |                                    |   |
| ><p>Of |                     |                                    |   |
| ficial |                     |                                    |   |
| Ti     |                     |                                    |   |
| tle</p |                     |                                    |   |
| ></li> |                     |                                    |   |
| </ul   |                     |                                    |   |
| ></td> |                     |                                    |   |
| </tr>  |                     |                                    |   |
| <tr    |                     |                                    |   |
| c      |                     |                                    |   |
| lass=" |                     |                                    |   |
| even"> |                     |                                    |   |
| <t     |                     |                                    |   |
| d><ul> |                     |                                    |   |
| <li><  |                     |                                    |   |
| p>Name |                     |                                    |   |
| of     |                     |                                    |   |
| Spon   |                     |                                    |   |
| soring |                     |                                    |   |
| Instit |                     |                                    |   |
| ute</p |                     |                                    |   |
| ></li> |                     |                                    |   |
| </ul   |                     |                                    |   |
| ></td> |                     |                                    |   |
| <t     |                     |                                    |   |
| d><ul> |                     |                                    |   |
| <li    |                     |                                    |   |
| ><p>De |                     |                                    |   |
| tailed |                     |                                    |   |
| De     |                     |                                    |   |
| script |                     |                                    |   |
| ion</p |                     |                                    |   |
| ></li> |                     |                                    |   |
| </ul   |                     |                                    |   |
| ></td> |                     |                                    |   |
| </tr>  |                     |                                    |   |
| <tr    |                     |                                    |   |
| class= |                     |                                    |   |
| "odd"> |                     |                                    |   |
| <t     |                     |                                    |   |
| d><ul> |                     |                                    |   |
| <li><  |                     |                                    |   |
| p>Purp |                     |                                    |   |
| ose</p |                     |                                    |   |
| ></li> |                     |                                    |   |
| </ul   |                     |                                    |   |
| ></td> |                     |                                    |   |
| <t     |                     |                                    |   |
| d><ul> |                     |                                    |   |
| <li><p |                     |                                    |   |
| >Eligi |                     |                                    |   |
| bility |                     |                                    |   |
| In     |                     |                                    |   |
| format |                     |                                    |   |
| ion</p |                     |                                    |   |
| ></li> |                     |                                    |   |
| </ul   |                     |                                    |   |
| ></td> |                     |                                    |   |
| </tr>  |                     |                                    |   |
| <tr    |                     |                                    |   |
| c      |                     |                                    |   |
| lass=" |                     |                                    |   |
| even"> |                     |                                    |   |
| <t     |                     |                                    |   |
| d><ul> |                     |                                    |   |
| <li><  |                     |                                    |   |
| p>Name |                     |                                    |   |
| of     |                     |                                    |   |
| D      |                     |                                    |   |
| isease |                     |                                    |   |
| or     |                     |                                    |   |
| Condit |                     |                                    |   |
| ion</p |                     |                                    |   |
| ></li> |                     |                                    |   |
| </ul   |                     |                                    |   |
| ></td> |                     |                                    |   |
| <t     |                     |                                    |   |
| d><ul> |                     |                                    |   |
| <li><p |                     |                                    |   |
| >Dates |                     |                                    |   |
| of     |                     |                                    |   |
| the    |                     |                                    |   |
| st     |                     |                                    |   |
| udy</p |                     |                                    |   |
| ></li> |                     |                                    |   |
| </ul   |                     |                                    |   |
| ></td> |                     |                                    |   |
| </tr>  |                     |                                    |   |
| <tr    |                     |                                    |   |
| class= |                     |                                    |   |
| "odd"> |                     |                                    |   |
| <t     |                     |                                    |   |
| d><ul> |                     |                                    |   |
| <li><  |                     |                                    |   |
| p>Name |                     |                                    |   |
| of     |                     |                                    |   |
| the    |                     |                                    |   |
| Tre    |                     |                                    |   |
| atment |                     |                                    |   |
| or     |                     |                                    |   |
| Int    |                     |                                    |   |
| ervent |                     |                                    |   |
| ion</p |                     |                                    |   |
| ></li> |                     |                                    |   |
| </ul   |                     |                                    |   |
| ></td> |                     |                                    |   |
| <t     |                     |                                    |   |
| d><ul> |                     |                                    |   |
| <li    |                     |                                    |   |
| ><p>Lo |                     |                                    |   |
| cation |                     |                                    |   |
| and    |                     |                                    |   |
| C      |                     |                                    |   |
| ontact |                     |                                    |   |
| In     |                     |                                    |   |
| format |                     |                                    |   |
| ion</p |                     |                                    |   |
| ></li> |                     |                                    |   |
| </ul   |                     |                                    |   |
| ></td> |                     |                                    |   |
| </tr>  |                     |                                    |   |
| <tr    |                     |                                    |   |
| c      |                     |                                    |   |
| lass=" |                     |                                    |   |
| even"> |                     |                                    |   |
| <t     |                     |                                    |   |
| d><ul> |                     |                                    |   |
| <li    |                     |                                    |   |
| ><p>Ph |                     |                                    |   |
| ase</p |                     |                                    |   |
| ></li> |                     |                                    |   |
| </ul   |                     |                                    |   |
| ></td> |                     |                                    |   |
| <t     |                     |                                    |   |
| d><ul> |                     |                                    |   |
| <li><  |                     |                                    |   |
| p>More |                     |                                    |   |
| Infor  |                     |                                    |   |
| mation |                     |                                    |   |
| Su     |                     |                                    |   |
| pplied |                     |                                    |   |
| by     |                     |                                    |   |
| Spon   |                     |                                    |   |
| soring |                     |                                    |   |
| Org    |                     |                                    |   |
| anizat |                     |                                    |   |
| ion</p |                     |                                    |   |
| ></li> |                     |                                    |   |
| </ul   |                     |                                    |   |
| ></td> |                     |                                    |   |
| </tr>  |                     |                                    |   |
| <tr    |                     |                                    |   |
| class= |                     |                                    |   |
| "odd"> |                     |                                    |   |
| <t     |                     |                                    |   |
| d><ul> |                     |                                    |   |
| <li><p |                     |                                    |   |
| >Links |                     |                                    |   |
| to     |                     |                                    |   |
| r      |                     |                                    |   |
| elated |                     |                                    |   |
| Medli  |                     |                                    |   |
| nePlus |                     |                                    |   |
| and    |                     |                                    |   |
| Ge     |                     |                                    |   |
| netics |                     |                                    |   |
| Home   |                     |                                    |   |
| Ref    |                     |                                    |   |
| erence |                     |                                    |   |
| top    |                     |                                    |   |
| ics</p |                     |                                    |   |
| ></li> |                     |                                    |   |
| </ul   |                     |                                    |   |
| ></td> |                     |                                    |   |
| <t     |                     |                                    |   |
| d><ul> |                     |                                    |   |
| <l     |                     |                                    |   |
| i><p>R |                     |                                    |   |
| eferen |                     |                                    |   |
| ces</p |                     |                                    |   |
| ></li> |                     |                                    |   |
| <l     |                     |                                    |   |
| i><p>R |                     |                                    |   |
| esults |                     |                                    |   |
| D      |                     |                                    |   |
| ata</p |                     |                                    |   |
| ></li> |                     |                                    |   |
| </ul   |                     |                                    |   |
| ></td> |                     |                                    |   |
| </tr>  |                     |                                    |   |
| <tr    |                     |                                    |   |
| c      |                     |                                    |   |
| lass=" |                     |                                    |   |
| even"> |                     |                                    |   |
| <t     |                     |                                    |   |
| d><ul> |                     |                                    |   |
| <li><p |                     |                                    |   |
| >Study |                     |                                    |   |
| Type   |                     |                                    |   |
| and    |                     |                                    |   |
| Des    |                     |                                    |   |
| ign</p |                     |                                    |   |
| ></li> |                     |                                    |   |
| </ul   |                     |                                    |   |
| ></td> |                     |                                    |   |
| <td    |                     |                                    |   |
| ></td> |                     |                                    |   |
| </tr>  |                     |                                    |   |
| </     |                     |                                    |   |
| tbody> |                     |                                    |   |
| </     |                     |                                    |   |
| table> |                     |                                    |   |
+--------+---------------------+------------------------------------+---+
|        |                     |                                    |   |
+--------+---------------------+------------------------------------+---+
|        |                     |                                    |   |
+--------+---------------------+------------------------------------+---+

**See next page for a partial view of a fuller record.**

Full Text View (partial display):

+---+--------------------------------------------------------------------+
| 1 | ![](media/image79.png){width="6.499305555555556in"                 |
|   | height="3.6770833333333335in"}                                     |
| 2 |                                                                    |
|   |                                                                    |
| 3 |                                                                    |
+---+--------------------------------------------------------------------+

Legend:

+-----------------+----------------------------------------------------+
| 1 Navigational  | Use the **Next Study** or **Previous Study** or    |
| area            | arrows to navigate through your retrieval.         |
|                 |                                                    |
|                 | Use **Return to Search Results** to get back to    |
|                 | your full retrieval in the short format.           |
+-----------------+----------------------------------------------------+
| 2 Tabs          | **Tabular View**: displays the fuller record in a  |
|                 | tabular/table format                               |
|                 |                                                    |
|                 | **Contacts and Locations**: displays the complete  |
|                 | list of contacts and locations for that specific   |
|                 | clinical trial                                     |
|                 |                                                    |
|                 | **Study Results**: As of September 24, 2008        |
|                 | summary results information from completed studies |
|                 | is displayed                                       |
|                 |                                                    |
|                 | **Related Studies**: method to find related        |
|                 | studies by searching for the conditions,           |
|                 | interventions, and sponsors found in that specific |
|                 | clinical trial                                     |
+-----------------+----------------------------------------------------+
| 3 Highlighting  | Searched terms are highlighted in a pale pink.     |
|                 |                                                    |
|                 | Synonyms of those terms are highlighted in a pale  |
|                 | yellow.                                            |
+-----------------+----------------------------------------------------+

At the *bottom* of the List Results brief display page there are options
for an RSS Feed and download options:

+---+----+---------------------------------------------------------------+
| 4 |    | ![](media/image80.png){width="3.8118055555555554in"           |
|   |    | height="2.1555555555555554in"}                                |
| 5 |    |                                                               |
+---+----+---------------------------------------------------------------+

Legend:

  ------------------ ----------------------------------------------------
  4 RSS Feed         Set up an **RSS Feed** for studies received in the
                     last 60 days for a particular search.

  5 Download Options Click **Download Options** to select options to
                     download studies to a zip file.
  ------------------ ----------------------------------------------------

**Tabular View (partial display):**

![](media/image81.png){width="6.499305555555556in"
height="2.938888888888889in"}

**Contacts and Locations:**

![](media/image82.png){width="6.499305555555556in"
height="3.842361111111111in"}

  ----------------------------------------------------- ------------------------------------------------------------
  ![](media/image4.jpeg){width="0.8333333333333334in"   Contact and Location information is also included in the
  height="0.9166666666666666in"}                        fuller record of the complete study.

  ----------------------------------------------------- ------------------------------------------------------------

**Study Results:**

![](media/image83.png){width="6.493055555555555in"
height="3.3743055555555554in"}

  ------------------------------------------------------ ------------------------------------------------------------
  ![](media/image77.jpeg){width="0.8645833333333334in"   Search NCT00440011 to see Study Results. See below (partial
  height="0.9263888888888889in"}                         display):

  ------------------------------------------------------ ------------------------------------------------------------

![](media/image84.png){width="6.499305555555556in"
height="4.090972222222222in"}

**Related Studies (partial display):**

![](media/image85.png){width="6.496527777777778in"
height="4.094444444444444in"}

## Display Options Menu {#display-options-menu .GatewayH2}

![](media/image86.png){width="1.4791666666666667in"
height="0.4895833333333333in"}

To customize your display, on the **List Results** page of your search
retrieval, click on the Display Options icon or link. Then, check the
fields you want to display. Note the fields are added/deleted as you
click in the field.

![](media/image87.png){width="5.468055555555556in" height="1.1875in"}

To hide the Display Options, click on the Hide Display Options icon or
link:

![](media/image88.png){width="1.5416666666666667in" height="0.40625in"}

## Advanced Search {#advanced-search .GatewayH2}

-   From the Basic Search page, click on the Advanced Search link or
    tab.

-   Use this page to conduct a more structured and targeted search.

-   The labels to the left of each box are links to further information
    about each field.

-   It is not necessary to fill in all the fields.

![](media/image89.png){width="6.502083333333333in"
height="7.641666666666667in"}

## Studies by Topic {#studies-by-topic .GatewayH2}

-   Easy way to search by selecting options from lists.

***Example: Click on Conditions by Category***

![](media/image90.png){width="6.384722222222222in"
height="3.032638888888889in"}

![](media/image91.png){width="5.540972222222222in"
height="4.686805555555556in"}

![](media/image92.png){width="6.322222222222222in"
height="3.363888888888889in"}

**List Results** for "Cleft Palate" studies (partial display):

![](media/image93.png){width="6.240972222222222in"
height="3.1465277777777776in"}

## Studies on Map {#studies-on-map .GatewayH2}

-   Easy way to search for clinical trials by location.

***Example: Click on United States.***

![](media/image94.png){width="6.4625in" height="7.055555555555555in"}

Click on the state of **Maine**:

![](media/image95.png){width="6.496527777777778in"
height="5.092361111111111in"}

Partial display of retrieval:

![](media/image96.png){width="6.240972222222222in"
height="2.6354166666666665in"}

[]{#__RefHeading___Toc210448711 .anchor}Refining your Search

***Example: Start with a search for lymphoma from the Basic Search
page:***

![](media/image97.png){width="5.707638888888889in"
height="1.6666666666666667in"}

-   Use the various tabs from the **List Results** to refine or further
    limit your search:

![](media/image98.png){width="6.377083333333333in"
height="4.122222222222222in"}

### Refine Search  {#refine-search .GatewayH3}

![](media/image99.png){width="6.497222222222222in"
height="7.141666666666667in"}

###  {#section-12 .GatewayH3}

  ----------------------------------------------------- ----------------------------------------------------------
  ![](media/image4.jpeg){width="0.8333333333333334in"   Notice that the Refine Search page is the Advanced Search
  height="0.9166666666666666in"}                        page with your previous search criteria retained for your
                                                        convenience.

  ----------------------------------------------------- ----------------------------------------------------------

###   {#section-13 .GatewayH3}

Results of Refine Search (partial display):

![](media/image100.png){width="6.4875in" height="4.802083333333333in"}

### Results by Topic {#results-by-topic .GatewayH3}

-   Narrow your results by selecting specific topical categories.

***Example: Use Results by Topic to narrow your original retrieval by
Drug Intervention:***

![](media/image101.png){width="6.469444444444444in"
height="3.323611111111111in"}

Then limit to **Antineoplastic Agents**:

![](media/image102.png){width="6.45in" height="2.602777777777778in"}

Next you reach a page with an alphabetic list of Antineoplastic Agents
to choose from (partial display):

Let's choose Cyclophosphamide:

![](media/image103.png){width="6.497916666666667in"
height="2.7090277777777776in"}

Results of search (partial display):

![](media/image104.png){width="6.35625in" height="3.886111111111111in"}

***Example: Use Results by Topic to narrow retrieval to a specific
location - Connecticut***

![](media/image105.png){width="6.461805555555555in"
height="3.4458333333333333in"}

![](media/image106.png){width="6.45in" height="2.2395833333333335in"}

Next, is a listing of states (partial display):

![](media/image107.png){width="6.377083333333333in"
height="4.186111111111111in"}

List Results (partial display):

![](media/image108.png){width="6.35625in" height="3.584722222222222in"}

### Results on Map {#results-on-map .GatewayH3}

Click geographic region to get fuller information.

![](media/image109.png){width="6.458333333333333in"
height="6.629166666666666in"}

![](media/image110.png){width="6.479166666666667in"
height="5.261805555555555in"}

**List Results** (partial display):

![](media/image111.png){width="6.428472222222222in"
height="3.313888888888889in"}

## ClinicalTrials.gov Identifier Number & PubMed {#clinicaltrials.gov-identifier-number-pubmed .GatewayH2}

-   In July 2005 NLM began including the ClinicalTrials.gov identifier
    number in MEDLINE records, when the article is devoted solely and
    entirely to announcing or reporting the results of the clinical
    trial.

-   The data displays in the Secondary Source ID field \[SI\] in the
    Citation and MEDLINE display formats. For additional information,
    see the May-June 2005 *NLM Technical Bulletin* article at
    <http://www.nlm.nih.gov/pubs/techbull/mj05/mj05_ct.html>.

-   Use ***clinicaltrials.gov \[si\]*** in PubMed to retrieve these
    citations.

  --------------------- -------------------------------------------------------------
  *PubMed's             ![](media/image112.png){width="5.720833333333333in"
  **Citation** format   height="6.354166666666667in"}
  displays links for    
  ClinicalTrials.gov    
  identifier numbers    
  that link you         
  directly to the       
  record in             
  ClinicalTrials.gov*   

  --------------------- -------------------------------------------------------------

[]{#__RefHeading___Toc210448716 .anchor}**Practice Exercises**

1.  Are there any clinical trials studying acupuncture? From the List
    Results page, hide the studies that are not seeking new volunteers.

2.  Find Phase III clinical trials for bladder cancer for an adult
    living in Texas who wants to get into a trial. (Hint: Use Advanced
    Search).

3.  Using the Studies by Topic tab, retrieve the clinical trials
    studying Cataracts. Once you have your retrieval, use the Results on
    Map tab to see the U.S. states where these studies are located.

**Suggested Answers**

1\. Are there any clinical trials studying acupuncture? From the List
Results page, hide the studies that are not seeking new volunteers.

![](media/image113.png){width="5.488888888888889in"
height="1.6145833333333333in"}

![](media/image114.png){width="6.440277777777778in"
height="2.7395833333333335in"}

![](media/image115.png){width="6.471527777777778in" height="2.75in"}

2\. Find Phase III clinical trials for bladder cancer for an adult
living in Texas who wants to get into a trial. (Hint: Use Advanced
Search).

![](media/image116.png){width="6.497222222222222in"
height="8.350694444444445in"}

3\. Using the Studies by Topic tab, retrieve the clinical trials
studying Cataracts. Once you have your retrieval, use the Results on Map
tab to see the U.S. states where these studies are located.

You can select the **Studies by Topic** tab from the Basic Search page:

![](media/image117.png){width="5.540972222222222in" height="1.625in"}

***OR***

Click on **Study Topics** from the top menu bar

![](media/image73.png){width="6.449305555555555in"
height="0.6659722222222222in"}

***OR***

From the home page you can click on **List by Condition** under **Study
Topics**:

![](media/image75.png){width="6.435416666666667in"
height="3.939583333333333in"}

Then select **Eye Diseases** from the Conditions by Category list:

![](media/image91.png){width="5.540972222222222in"
height="4.686805555555556in"}

Select **Cataract** from the next list (partial display):

![](media/image118.png){width="6.502777777777778in"
height="3.303472222222222in"}

Once you've reached the list of Cataract studies, click the **Results on
Map** tab:

![](media/image119.png){width="6.445138888888889in"
height="3.8229166666666665in"}

From World Map, click on United States:

![](media/image120.png){width="6.423611111111111in"
height="4.440277777777778in"}

Map of United States for the cataract studies is below. Please note that
if you scroll down further on the Results on Map page, you will see a
textual version of this same information.

![](media/image121.png){width="6.436111111111111in"
height="5.444444444444445in"}

**[N]{.underline} [O]{.underline} [T]{.underline} [E]{.underline}
[S]{.underline}**