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<tbody>
<tr class="odd">
<td colspan="6"><p>Name(s) of Risk Team Members:</p>
<p>Diane Cabelli, Doug Marsteller, Dave Schlyer, Ann Emrick</p></td>
<td colspan="4"><p>Point Value →</p>
<p>Parameter ↓</p></td>
<td colspan="6">1</td>
<td colspan="3">2</td>
<td colspan="2">3</td>
<td colspan="7">4</td>
<td colspan="3">5</td>
</tr>
<tr class="even">
<td colspan="6"><p>Job Title: Scanning Rodent in MicroPET</p>
<p>Job Number or Job Identifier: DJ-JRA03-Rodents</p></td>
<td colspan="4"><p>Frequency</p>
<p>(B)</p></td>
<td colspan="6"><u>&lt;</u>once/year</td>
<td colspan="3"><u>&lt;</u>once/month</td>
<td colspan="2"><u>&lt;</u>once/week</td>
<td colspan="7"><u>&lt;</u>once/shift</td>
<td colspan="3">&gt;once/shift</td>
</tr>
<tr class="odd">
<td colspan="6"><p>Job Description:</p>
<p>Use of radiolabelled compound, micropet, rodent, ketamine</p></td>
<td colspan="4"><p>Severity</p>
<p>(C)</p></td>
<td colspan="6">First Aid Only</td>
<td colspan="3">Medical Treatment</td>
<td colspan="2">Lost Time</td>
<td colspan="7">Partial Disability</td>
<td colspan="3">Death or Permanent Disability</td>
</tr>
<tr class="even">
<td colspan="6"><p>Training and Procedures List (optional):</p>
<p>As defined in ESR CO-11-25</p></td>
<td colspan="4" rowspan="2"><p>Likelihood</p>
<p>(D)</p></td>
<td colspan="6" rowspan="2">Extremely Unlikely</td>
<td colspan="3" rowspan="2">Unlikely</td>
<td colspan="2" rowspan="2">Possible</td>
<td colspan="7" rowspan="2">Probable</td>
<td colspan="3" rowspan="2">Multiple</td>
</tr>
<tr class="odd">
<td colspan="6">Approved by: Bob Colichio Date: 7/24/06 Rev. #: 0</td>
</tr>
<tr class="even">
<td colspan="5"><p>Stressors (if applicable, please list all):</p>
<p>None.</p></td>
<td colspan="15">Reason for Revision (if applicable):</td>
<td colspan="11">Comments:</td>
</tr>
<tr class="odd">
<td colspan="8"></td>
<td colspan="9">Before Additional Controls</td>
<td colspan="6"></td>
<td colspan="7">After Additional Controls</td>
<td></td>
</tr>
<tr class="even">
<td>Job Step / Task</td>
<td colspan="2">Hazard</td>
<td colspan="4">Control(s)</td>
<td colspan="2"><blockquote>
<p><strong>Stressors Y/N</strong></p>
</blockquote></td>
<td colspan="3"><blockquote>
<p><strong># of People A</strong></p>
</blockquote></td>
<td><blockquote>
<p><strong>Frequency B</strong></p>
<p><strong>A</strong></p>
</blockquote></td>
<td><blockquote>
<p><strong>Severity C</strong></p>
</blockquote></td>
<td><blockquote>
<p><strong>Likelihood D</strong></p>
</blockquote></td>
<td colspan="2"><blockquote>
<p><strong>Risk* AxBxCxD</strong></p>
</blockquote></td>
<td colspan="5">Control(s) Added to Reduce Risk</td>
<td><blockquote>
<p><strong>Stressors Y/N</strong></p>
</blockquote></td>
<td colspan="2"><blockquote>
<p><strong># of People A</strong></p>
</blockquote></td>
<td><blockquote>
<p><strong>Frequency B</strong></p>
</blockquote></td>
<td><blockquote>
<p><strong>Severity C</strong></p>
</blockquote></td>
<td colspan="2"><blockquote>
<p><strong>Likelihood D</strong></p>
</blockquote></td>
<td><blockquote>
<p><strong>Risk* AxBxCxD</strong></p>
</blockquote></td>
<td>% Risk Reduction</td>
</tr>
<tr class="odd">
<td>Check out van from CO (Bldg 555), drive to MO (Bldg 490), collect
rodents from BLAF, transport to Bldg 906 and return van to CO (Bldg
555)</td>
<td colspan="2">Accident backing out van from poor visibility, accident
driving, dropping rodent containers, accident backing van from 906</td>
<td colspan="4">Parking spaces located where visibility is good
(assessed in CO previously), driving on site assessed in sitewide JRA,
rodents not infected with any hazardous material so posting of van is
not necessary, rodents in plexiglass carrier with lid, LAT training,
legal drivers license</td>
<td colspan="2">N</td>
<td colspan="3">1</td>
<td>4</td>
<td>3</td>
<td>3</td>
<td colspan="2">36</td>
<td colspan="5"></td>
<td></td>
<td colspan="2"></td>
<td></td>
<td></td>
<td colspan="2"></td>
<td></td>
<td></td>
</tr>
<tr class="even">
<td>Allow rodents to acclimate at Bldg 906 prior to experiment, bring
lab book and material to 906 for experiment.</td>
<td colspan="2">Rodents escape while at 906, transport of materials,
animal mixup, loss of control of rad material</td>
<td colspan="4">No need to transport controlled substances because
satellite pharmacy is in micropet room at 906. Rodents in plexiglass
cages with lids, each cage labeled with owner name to prevent mixup,
rodent put on hot side of room, careful delineation between hot and
surveyed clean material.</td>
<td colspan="2">N</td>
<td colspan="3">1</td>
<td>4</td>
<td>1</td>
<td>2</td>
<td colspan="2">8</td>
<td colspan="5"></td>
<td></td>
<td colspan="2"></td>
<td></td>
<td></td>
<td colspan="2"></td>
<td></td>
<td></td>
</tr>
<tr class="odd">
<td>Area prepared for experiment, FDG arrives: Human FDG dose
transferred to a sterile vial and remainder transported to micropet room
(offsite delivery arrives in syringe/onsite synthesized material arrives
in syringe)</td>
<td colspan="2">Radiation exposure</td>
<td colspan="4">Fresh chucks in place form previous researcher, confirm
that counters are covered, fresh chuck on moveable arm of micropet, vial
delivered in lead-shielded container and placed in shielded space. PPE
required: Finger ring, dosimetry badge, lab coat, booties for entry into
rad space, double gloves, safety glasses with side shields, transfer
using tongs</td>
<td colspan="2">N</td>
<td colspan="3">1</td>
<td>4</td>
<td>1</td>
<td>3</td>
<td colspan="2">12</td>
<td colspan="5"></td>
<td></td>
<td colspan="2"></td>
<td></td>
<td></td>
<td colspan="2"></td>
<td></td>
<td></td>
</tr>
<tr class="even">
<td>Lift vial with tongs, hold vial with second tongs, fill syringe with
FDG, measuring dose in syringe and adding more until 0.8-1 mCurie
present. Place syringe in shielded space and place vial back into lead
Pig, record readings.</td>
<td colspan="2">Radiation exposure, air in syringe,</td>
<td colspan="4">Use of tongs removes radiation source 6-8 inches from
fingers, syringes are prefilled with small amount of saline to eliminate
need to remove bubble and limit time exposure, PPE as above, all
computers in rad area to eliminate need for frisking out during this
process</td>
<td colspan="2">N</td>
<td colspan="3">1</td>
<td>5</td>
<td>1</td>
<td>3</td>
<td colspan="2">15</td>
<td colspan="5"></td>
<td></td>
<td colspan="2"></td>
<td></td>
<td></td>
<td colspan="2"></td>
<td></td>
<td></td>
</tr>
<tr class="odd">
<td>Lift rodent and inject with FDG (IP), return rodent to cage, measure
residual dose in syringe and place syringe into used needle
container</td>
<td colspan="2">Radiation exposure, needle stick, rodent mixup, tripping
because of speed needed to carry out procedure to limit radiation
exposure</td>
<td colspan="4">Rodent labeled on tail with permanent marker to prevent
mixup, room reorganized to limit tripping hazards, entire middle of room
clear, animal held high enough that if researcher’s hand slips,
injection will go into air, syringe held with finger and thumb and
injection of material using another finger such that inserting needle is
a separate motion from injecting material, PPE as above, pass hands over
frisker and change outer layer of gloves to limit rad
contamination.</td>
<td colspan="2">N</td>
<td colspan="3">1</td>
<td>5</td>
<td>2</td>
<td>2</td>
<td colspan="2">20</td>
<td colspan="5"></td>
<td></td>
<td colspan="2"></td>
<td></td>
<td></td>
<td colspan="2"></td>
<td></td>
<td></td>
</tr>
<tr class="even">
<td>FDG uptake is 45 minutes, scan is ca 20 minutes, many animals can be
prepared at once and run in sequence</td>
<td colspan="2">Rapid timing leading to mistakes</td>
<td colspan="4">Uptake can be 40-65 minutes so there is slack built into
schedule</td>
<td colspan="2">N</td>
<td colspan="3">1</td>
<td>5</td>
<td>1</td>
<td>3</td>
<td colspan="2">15</td>
<td colspan="5"></td>
<td></td>
<td colspan="2"></td>
<td></td>
<td></td>
<td colspan="2"></td>
<td></td>
<td></td>
</tr>
<tr class="odd">
<td>First animal is anaesthetized with ketamine, reflexes checked,
placed on arm of micropet, head fixed in holder, and scanned</td>
<td colspan="2">Needle stick, animal not truly anaesthetized and moves,
rodent wakes during scan, rad exposure from blood/urine, radiation
exposure from hot animal</td>
<td colspan="4">Animal held high enough that if researcher’s hand slips,
injection will go into air, syringe held with finger and thumb and
injection of material using another finger such that inserting needle is
a separate motion from injecting material, reflexes checked by shaking
and withdrawing hind paw, LAT training, door shut to prevent any rodent
escape, PPE as above, injection over cage and cage on chuck-lined
counter to prevent leak of blood/urine to floor, speed necessary as
animal now represents largest dose of rad in room</td>
<td colspan="2">N</td>
<td colspan="3">1</td>
<td>5</td>
<td>1</td>
<td>2</td>
<td colspan="2">10</td>
<td colspan="5"></td>
<td></td>
<td colspan="2"></td>
<td></td>
<td></td>
<td colspan="2"></td>
<td></td>
<td></td>
</tr>
<tr class="even">
<td>Scan complete, rodent removed from micropet and returned to cage,
cage transferred to space designated for scanned and hot rodents.</td>
<td colspan="2">Radiation contamination, radiation exposure
tripping</td>
<td colspan="4">Chuck on moveable arm of micropet changed if any
evidence of blood/urine, speed in removing animal to limit researcher
exposure, space for cages in far corner of room to limit background rad
exposure, PPE as above, survey of gloves and change of outer glove as
necessary.</td>
<td colspan="2">N</td>
<td colspan="3">1</td>
<td>5</td>
<td>2</td>
<td>2</td>
<td colspan="2">20</td>
<td colspan="5"></td>
<td></td>
<td colspan="2"></td>
<td></td>
<td></td>
<td colspan="2"></td>
<td></td>
<td></td>
</tr>
<tr class="odd">
<td>Cleanup of space, removal of old chucks and relining of space with
clean chucks, all rodents on back shelf awaiting survey out, survey out
of researcher and lab book/pen etc.</td>
<td colspan="2">Radiation contamination, radiation exposure</td>
<td colspan="4">Check to ensure chucks in garbage, used syringes and
needles in needle boxes, all rad material in vial in shielded pig, PPE
as above, all rodents on back shelf, list of numbers to contact in event
of contamination, list of evening numbers for working after hours and
contamination, telephone available in rad space (? yes).</td>
<td colspan="2">N</td>
<td colspan="3">1</td>
<td>4</td>
<td>1</td>
<td>1</td>
<td colspan="2">4</td>
<td colspan="5"></td>
<td></td>
<td colspan="2"></td>
<td></td>
<td></td>
<td colspan="2"></td>
<td></td>
<td></td>
</tr>
<tr class="even">
<td>Van driven from 555 to 906, rodents transported by van back to BLAF
and van returned to 555</td>
<td colspan="2">See 1</td>
<td colspan="4">See 1</td>
<td colspan="2">N</td>
<td colspan="3">1</td>
<td>4</td>
<td>3</td>
<td>3</td>
<td colspan="2">36</td>
<td colspan="5"></td>
<td></td>
<td colspan="2"></td>
<td></td>
<td></td>
<td colspan="2"></td>
<td></td>
<td></td>
</tr>
<tr class="odd">
<td colspan="31">Further Description of Controls Added to Reduce
Risk:</td>
</tr>
<tr class="even">
<td colspan="2">*Risk:</td>
<td colspan="2">0 to 20</td>
<td colspan="7">21 to 40</td>
<td colspan="7">41-60</td>
<td colspan="6">61 to 80</td>
<td colspan="7">81 or greater</td>
</tr>
<tr class="odd">
<td colspan="2"></td>
<td colspan="2">Negligible</td>
<td colspan="7">Acceptable</td>
<td colspan="7">Moderate</td>
<td colspan="6">Substantial</td>
<td colspan="7">Intolerable</td>
</tr>
</tbody>
</table>