**DRAFT**

**3/16/06**

**UNITED STATES ENVIRONMENTAL PROTECTION AGENCY**

**HUMAN STUDIES REVIEW BOARD (HSRB)**

**PUBLIC MEETING**

**Tuesday, April 4, 2006**

**Holiday Inn -- Rosslyn at Key Bridge**

**1900 North Fort Myer Drive**

**Arlington, VA 22209**

**703-807-2000**

**HSRB WEB SITE http://www.epa.gov/osa/hsrb/**

**Docket Telephone: (202) 566 1752**

**Docket Number: EPA-HQ-ORD-2006-0187**

**8:30 AM Introduction and Identification of Board Members** -- HSRB
Chair

**8:45 AM Welcome --** George Gray, Ph.D. (EPA Science Advisor)

**9:00 AM Opening Remarks --** Ms. Susan Hazen (Acting Assistant
Administrator, Office of Prevention, Pesticides and Toxic Substances,
EPA)

**9:15 AM Meeting Administrative Procedures** - Paul Lewis, Ph.D.
(Designated Federal Officer, HSRB, EPA)

**Session 1: Introduction**

**9:20 AM Session 1 Overview --** Mr. William Jordan (Office of
Pesticide Programs \[OPP\], EPA)

**9:25 AM Summary of EPA's Protections for Subjects of Human Research
-** Mr. William Jordan (OPP, EPA)

**10:05 AM Break**

**10:20 AM EPA, OPP Assessment of Ethical Conduct of Human Studies** --
Mr. John Carley (OPP, EPA)

**10:45 AM EPA, OPP Approach to Assessing Human Health Risks of
Pesticides Using Data From Human Studies** -- Mr. Michael Metzger (OPP,
EPA)

**11:05 AM EPA, OPP Assessment of Individual Human Studies** -- Ray
Kent, Ph.D. (OPP, EPA)

**11:35 AM EPA, OPP Policy on "The Use of Data on Cholinesterase
Inhibition for Risk Assessment of Organophosphorous and Carbamate
Pesticides"** -- Anna Lowit, Ph.D. (OPP, EPA)

**12:00 PM Lunch**

**Session 2: Carbamate Pesticides**

**1:00 PM Session 2 Overview --** Anna Lowit, Ph.D. (OPP, EPA)

**1:05 PM Science and Ethics of Aldicarb Human Studies** - Linda Taylor,
Ph.D. (OPP, EPA) and Mr. John Carley (OPP, EPA)

**1:30 PM Science and Ethics of Methomyl Human Studies** -- Elissa
Reaves, Ph.D. (OPP, EPA) and Mr. John Carley (OPP, EPA)

**2:00 PM Science and Ethics of Oxamyl Human Studies** -- Elissa Reaves,
Ph.D. (OPP, EPA) and Mr. John Carley (OPP, EPA)

**2:45 PM Break**

**3:00 PM Public Comments on Session 2**

**4:15 PM HSRB Writing Session**

**5:15 PM Adjourn**

**UNITED STATES ENVIRONMENTAL PROTECTION AGENCY**

**HUMAN STUDIES REVIEW BOARD (HSRB)**

**PUBLIC MEETING**

**Wednesday, April 5, 2006**

**Holiday Inn -- Rosslyn at Key Bridge**

**1900 North Fort Myer Drive**

**Arlington, VA 22209**

**703-807-2000**

**HSRB WEB SITE http://www.epa.gov/osa/hsrb/**

**ORD Docket Telephone: (202) 564 1752**

**ORD Docket Number: EPA-HQ-ORD-2006-0187**

**8:30 AM Convene Meeting** -- HSRB Chair

**8:40 AM Followup From Previous Day's Discussion --** Mr. William
Jordan (OPP, EPA)

**8:50 AM Board Discussion**

**10:15 PM Break**

**Session 3: Organophosphate Pesticides**

**10:30 PM Session 3 Overview --** Ray Kent, Ph.D. (OPP, EPA)

**10:35 AM Science and Ethics of AZM Human Studies** -- John Doherty,
Ph.D. (OPP, EPA) and Mr. John Carley (OPP, EPA)

**11:00 AM Science and Ethics of DDVP Human Studies --** Ray Kent, Ph.D.
(OPP, EPA) and Mr. John Carley (OPP, EPA)

**11:45 PM Lunch**

**12:45 PM Public Comments on Session 3**

**2:00 PM Board Discussion**

**3:15 PM Break**

**Session 4: Other Pesticides**

**3:30 PM Session Overview --** Ray Kent, Ph.D. (OPP, EPA)

**3:35 PM Science and Ethics of Ethephon** - Ray Kent, Ph.D. (OPP, EPA)
and Mr. John Carley (OPP, EPA)

**4:00 PM Science and Ethics of Amitraz Human Studies** -- John
Liccione, Ph.D. (OPP, EPA) and Mr. John Carley (OPP, EPA)

**4:30 PM HSRB Writing Session**

**5:30 PM Adjournment**

**UNITED STATES ENVIRONMENTAL PROTECTION AGENCY**

**HUMAN STUDIES REVIEW BOARD (HSRB)**

**PUBLIC MEETING**

**Thursday, April 6, 2006**

**Holiday Inn -- Rosslyn at Key Bridge**

**1900 North Fort Myer Drive**

**Arlington, VA 22209**

**703-807-2000**

**HSRB WEB SITE http://www.epa.gov/osa/hsrb/**

**ORD Docket Telephone: (202) 564 1752**

**ORD Docket Number: EPA-HQ-ORD-2006-0187**

**8:30 AM Convene Meeting** -- HSRB Chair

**8:45 AM Followup From Previous Day's Discussion --** Mr. William
Jordan (OPP, EPA)

**9:00 PM Science and Ethics of Sodium Cyanide Human Studies --**
William Dykstra, Ph.D. (OPP, EPA) and Mr. John Carley (OPP, EPA)

**9:30 AM Public Comments on Session 4**

**10:30 AM Break**

**10:45 AM Board Discussion**

**12:00 PM Lunch**

**1:00 PM HSRB Writing Session**

**4:30 PM Adjournment**

Please be advised that agenda times are approximate. For further
information, please contact the Designated Federal Officer for this
meeting, Paul Lewis via telephone: (202) 564-8381 or email:
lewis.paul@epa.gov