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**BNL-9 RUN**

**FINAL REPORT**

# Marcelo E. Vazquez

####### Medical Department

**NASA-BNL Liaison Scientist**

**BNL/NASA webpage:**

**http://www.bnl.gov/medical/NASA/NASA-home%20frame.htm**

**December 2003**

**TABLE OF CONTENTS**

Executive Summary 3

BNL-9 Proposals/SACR Review 4

Participants 5

Participants Statistics 7

Participants Institutions 8

Iron Run Dates/Beam Time Description 9

Silicon Run Dates/Beam Time Description 10

Total BNL-9 Run Dates/Beam Time Description 11

Descriptive Statistics 12

Beam Characteristics 15

Run Statistics and Incidents 16

Experimenters and Run Statistics 18

Participants, Experimental Samples and Endpoints 19

List of Personnel 21

####### EXECUTIVE SUMMARY

During the fall of 2002 a series of radiobiological and physics
experiments were performed using the BNL's Alternating Gradient
Synchrotron to accelerate iron ion beams (Experiment 960, BNL-9). These
experiments were part of the ninth consecutive run sponsored by NASA's
Space Radiation Health Program (SRHP) heavy ion radiobiology research
program at BNL.

A total of 28 proposals were approved to participate in the BNL-9 run,
10 of which was a renewal, 9 were continuing projects and 9 which were
new proposals. Six groups (six proposals) were not able to participate
during BNL-9. Only one piggyback experiment was approved for BNL-9.
Therefore, 22 groups affiliated to fourteen institutions from the United
States and 4 from foreign countries (Italy and Japan) were represented,
totaling 86 users.

More than 2000 biological samples were irradiated at the AGS A-3 beam
line, employing 184.5 hours of beam time (48 hours for in vivo studies
and 73 hours for in vitro studies). In addition, 25 hours were used for
physics experiments, and a total of 38.5 hours were necessary for beam
characterization, tuning, dosimetry, and calibration. A total of 28.5
hours of beam time were lost (15.4%) due to accelerator or power supply
related problems.

During BNL-9, AGS provided iron (1.046 GeV/nucleon, LET: 148 keV/µm and
5 GeV/n, LET beams and Si (0.6 GeV/n, LET: 49.5 keV/µm) for biology and
physics experiments. The dose/rates used were as low as 10 cGy/min and
as high as 15 Gy/min. The spill rate employed was 30 spills/min with a
duration of 500-600 msec/spill. The spill fluence was (particles/spill)
1 x 10^8^ (max) and 1.5 x 10^5^ (min). The intensities
(particles/cm^2^/sec on target) used during the run were 1 x 10^8^ (max)
and 400 (min). A 7.5-cm diameter beam spot was employed as a nominal
spot for the majority of the exposures. For larger samples (animals), an
elliptical spot was used (up to 9 cm).

Tandem-Booster set-up started on November 4 with the transport and
circulation of Fe beams at the AGS complex. Beam was tuned into cave on
November 5. 5 GeV/n Fe ion beams were available for tuning on November
6. The next several shifts were spent on tuning into the target area,
beam diagnostics and establishing several different combinations of beam
intensities and spot shapes and sizes for physics and biology runs.
Physics studies started on the morning of October 7 as planned. Biology
studies started on the morning of November 8 (A. Kennedy, Peen. U.) and
proceeded through November 10. Late on the same day, AGS tuned 1GeV/n
iron beams for physics studies for 9 hours. Biology studies started on
November 11 (L. Green, LLUMC) and continued until early November 15. On
November 15 (0200AM) AGS started tuning Si ions 0.6 GeV/n for biology
studies (Gewirtz, Penn. U.) running until early morning on November 16.
BNL-9 officially ended at 0400AM, November 16, 2002.

Radiobiological experiments employed cells, tissues, and intact
specimens, which required a complex coordination and planning of their
respective logistic support. Biological studies used human, mouse, rat
and hamster cell lines, human-hamster hybrid cell lines, tumor cell
lines and intact specimens (rodents and fish). Physics experiments
involved the exposure of solid state detectors and spacecraft materials.
The full program was completed in 9 days.

BNL-9 Projects Reviewed by the BNL's Scientific Advisory Committee in
Radiobiology (SACR):

+--------+------------------+---+-------------+------------+--------------+
| **Pro  | > **P.I.**       |   | **Status**  | **Funding  | **BNL-9      |
| ject** |                  |   |             | Source**   | Par          |
|        |                  |   |             |            | ticipation** |
+--------+------------------+---+-------------+------------+--------------+
| *      | > **             |   | **Renewal** | **NASA**   | **Yes**      |
| *B-1** | Zeitlin/Miller** |   |             |            |              |
+--------+------------------+---+-------------+------------+--------------+
| *      | >                |   | **Renewal** | **NASA**   | **Yes**      |
| *B-3** | **Cucinotta/Wu** |   |             |            |              |
+--------+------------------+---+-------------+------------+--------------+
| *      | > **Rabin**      |   | **Renewal** | **NASA**   | **Yes**      |
| *B-7** |                  |   |             |            |              |
+--------+------------------+---+-------------+------------+--------------+
| **     | > **Chang**      |   | **Renewal** | **NASA**   | **No**       |
| B-10** |                  |   |             |            |              |
+--------+------------------+---+-------------+------------+--------------+
| **     | > **Kronenberg** |   | **Renewal** | **NASA**   | **No**       |
| B-19** |                  |   |             |            |              |
+--------+------------------+---+-------------+------------+--------------+
| **     | > **Durante**    |   | **Renewal** | **ASI**    | **Yes**      |
| B-44** |                  |   |             |            |              |
+--------+------------------+---+-------------+------------+--------------+
| **     | > **Setlow**     |   | **Renewal** | **NASA**   | **Yes**      |
| B-45** |                  |   |             |            |              |
+--------+------------------+---+-------------+------------+--------------+
| **     | > **Murnane**    |   | **Renewal** | **NASA**   | **Yes**      |
| B-51** |                  |   |             |            |              |
+--------+------------------+---+-------------+------------+--------------+
| **     | > **Gerwitz**    | > |             | **NSBRI**  | **Yes**      |
| B-52** |                  |   |             |            |              |
|        |                  | * |             |            |              |
|        |                  | * |             |            |              |
|        |                  | R |             |            |              |
|        |                  | e |             |            |              |
|        |                  | n |             |            |              |
|        |                  | e |             |            |              |
|        |                  | w |             |            |              |
|        |                  | a |             |            |              |
|        |                  | l |             |            |              |
|        |                  | * |             |            |              |
|        |                  | * |             |            |              |
+--------+------------------+---+-------------+------------+--------------+
| **     | > **Lupton**     |   | **Renewal** | **NSBRI**  | **Yes**      |
| B-53** |                  |   |             |            |              |
+--------+------------------+---+-------------+------------+--------------+
| **     | > **Kennedy**    |   | **C         | **NSBRI**  | **Yes**      |
| B-54** |                  |   | ontinuing** |            |              |
+--------+------------------+---+-------------+------------+--------------+
| **     | > **Koniarek**   |   | **C         | **P        | **Yes**      |
| B-57** |                  |   | ontinuing** | iggyback** |              |
+--------+------------------+---+-------------+------------+--------------+
| **     | > **Chen**       |   | **C         | **NASA**   | **No**       |
| B-58** |                  |   | ontinuing** |            |              |
+--------+------------------+---+-------------+------------+--------------+
| **     | > **Obenaus**    |   | **C         | **NASA**   | **Yes**      |
| B-62** |                  |   | ontinuing** |            |              |
+--------+------------------+---+-------------+------------+--------------+
| **     | > **Nelson**     |   | **C         | **NASA**   | **Yes**      |
| B-63** |                  |   | ontinuing** |            |              |
+--------+------------------+---+-------------+------------+--------------+
| **     | > **Vazquez**    |   | **C         | **NSBRI**  | **Yes**      |
| B-64** |                  |   | ontinuing** |            |              |
+--------+------------------+---+-------------+------------+--------------+
| **     | > **Vazquez**    |   | **C         | **NSBRI**  | **Yes**      |
| B-65** |                  |   | ontinuing** |            |              |
+--------+------------------+---+-------------+------------+--------------+
| **     | > **Narici**     |   | **C         | **ASI**    | **No**       |
| B-66** |                  |   | ontinuing** |            |              |
+--------+------------------+---+-------------+------------+--------------+
| **     | > **Blakely**    |   | **C         | **NASA**   | **No**       |
| B-67** |                  |   | ontinuing** |            |              |
+--------+------------------+---+-------------+------------+--------------+
| **     | >                |   | **New**     | **NASA**   | **Yes**      |
| B-68** |  **Hall/Worgul** |   |             |            |              |
+--------+------------------+---+-------------+------------+--------------+
| **     | > **Nelson**     |   | **New**     | **NASA**   | **Yes**      |
| B-69** |                  |   |             |            |              |
+--------+------------------+---+-------------+------------+--------------+
| **     | > **             |   | **New**     | **NASA**   | **No**       |
| B-70** | Barcellos_Hoff** |   |             |            |              |
+--------+------------------+---+-------------+------------+--------------+
| **     | > **Burns**      |   | **New**     | **NASA**   | **Yes**      |
| B-71** |                  |   |             |            |              |
+--------+------------------+---+-------------+------------+--------------+
| **     | > **Gonda**      |   | **New**     | **NASA**   | **Yes**      |
| B-72** |                  |   |             |            |              |
+--------+------------------+---+-------------+------------+--------------+
| **     | > **Sutherland** |   | **New**     | **         | **Yes**      |
| B-73** |                  |   |             | DOE/NASA** |              |
+--------+------------------+---+-------------+------------+--------------+
| **     | > **Chatterjee** |   | **New**     | **NASA**   | **Yes**      |
| B-74** |                  |   |             |            |              |
+--------+------------------+---+-------------+------------+--------------+
| **     | > **Ford**       |   | **New**     | **         | **Yes**      |
| B-75** |                  |   |             | DOE/NASA** |              |
+--------+------------------+---+-------------+------------+--------------+
| **     | > **Green**      |   | **New**     | **         | **Yes**      |
| B-76** |                  |   |             | DOE/NASA** |              |
+--------+------------------+---+-------------+------------+--------------+

**[BNL-9 PARTICIPANTS]{.underline}**

+----+--------------+-----------------------------+-------------------+
| ** | **Pa         | **Affiliation**             | **Title**         |
| Ex | rticipants** |                             |                   |
| p. |              |                             |                   |
| ** |              |                             |                   |
+----+--------------+-----------------------------+-------------------+
| B  | C. Zeitlin.  | Lawrence Berkeley National  | Ph.D., Principal  |
| -1 |              | Laboratory, CA              | Investigator      |
|    | J. Miller    |                             |                   |
|    |              | \"                          | Ph.D.,            |
|    | L. Heilbronn |                             | Co-Principal      |
|    |              | \"                          | Investigator      |
|    | R.P. Sigh    |                             | Ph.D., Co-Worker  |
|    |              | \"                          |                   |
|    | W. Holley    |                             | Ph.D., Co-Worker  |
|    |              | \"                          |                   |
|    | W.           |                             | Ph.D., Co-Worker  |
|    | Schimmerling | NASA, HDQ, DC               |                   |
|    |              |                             | Ph.D., Co-Worker  |
+----+--------------+-----------------------------+-------------------+
| B  | F.           | NASA, Johnson Space Center, | Ph.D., Principal  |
| -3 | Cucinotta\*  | TX                          | Investigator      |
|    |              |                             |                   |
|    | H. Wu        | "                           | Ph.D.,            |
|    |              |                             | CoPrincipal       |
|    | P. Sagamti   | "                           | Investigator      |
|    |              |                             |                   |
|    | K. George    | "                           | Ph.D., Co-Worker  |
|    |              |                             |                   |
|    | V.           | "                           | Senior Research   |
|    | Willingham   |                             | Associate         |
|    |              |                             |                   |
|    |              |                             | BS, Co-Worker     |
+----+--------------+-----------------------------+-------------------+
| B  | B. Rabin     | University of Maryland,     | Ph.D., Principal  |
| -7 |              | Baltimore County, MD        | Investigator      |
|    | J. Joseph    |                             |                   |
|    |              | Human Nutrition Research    | Ph.D.,            |
|    | B.           | Center on Aging, MA         | Co-Principal      |
|    | Sukitt-Hale  |                             | Investigator      |
|    |              | "                           |                   |
|    | J. McEwen    |                             | Co-Worker         |
|    |              | "                           |                   |
|    | S.           |                             | Co-Worker         |
|    | Szprengiel   | "                           |                   |
|    |              |                             | Co-Worker         |
|    | D. Jenkins   | "                           |                   |
|    |              |                             | Co-Worker         |
|    | A. Eggleston |                             |                   |
+----+--------------+-----------------------------+-------------------+
| B- | M. Durante\* | University "Federico II",   | Ph.D., Principal  |
| 44 |              | Napoli, Italy               | Investigator      |
|    | M. Belli     |                             |                   |
|    |              | National Institute of       | Ph.D., Co-Worker  |
|    | G. Simone    | Health, Rome, Italy         |                   |
|    |              |                             | Ph.D., Co-Worker  |
|    | P. Scampoli  | "                           |                   |
|    |              |                             | Ph.D., Co-Worker  |
|    | G. Grossi    | "                           |                   |
|    |              |                             | Ph.D., Co-Worker  |
|    |              | University "Federico II",   |                   |
|    |              | Napoli, Italy               |                   |
+----+--------------+-----------------------------+-------------------+
| B- | R. Setlow    | Brookhaven National         | Ph.D., Principal  |
| 45 |              | Laboratory, NY              | Investigator      |
|    | J. Jardine   |                             |                   |
|    |              | "                           | BS, Co-Worker     |
|    | A. Shima     |                             |                   |
|    |              | University of Tokyo, Japan  | Ph.D., Co-Worker  |
+----+--------------+-----------------------------+-------------------+
| B- | J. Murnane\* | University of California,   | Ph.D., Principal  |
| 51 |              | San Francisco, CA           | Investigator      |
|    | B. Fouladi   |                             |                   |
|    |              | "                           | Ph.D., Co-Worker  |
|    | R. Eltanal   |                             |                   |
|    |              | "                           | BS, Co-Worker     |
+----+--------------+-----------------------------+-------------------+
| B- | J. Gerwitz\* | NSBRI, University of        | Ph.D., Principal  |
| 52 |              | Pennsylvania                | Investigator      |
|    | B.           |                             |                   |
|    | Sutherland   | Brookhaven National         | Ph.D.,            |
|    |              | Laboratory, NY              | Co-Investigator   |
|    | P. Bennett   |                             |                   |
|    |              | "                           | MS., Biology      |
|    | J.           |                             | Associate.        |
|    | Sutherland   | "                           |                   |
|    |              |                             | Ph.D., Co-Worker  |
|    | P. Guida     | "                           |                   |
|    |              |                             | Ph.D., Co-Worker  |
|    | J. Trunk     | "                           |                   |
|    |              |                             | Co-Worker         |
|    | D.           | "                           |                   |
|    | Monteleone   |                             | Co-Worker         |
+----+--------------+-----------------------------+-------------------+
| B- | J. Lupton\*  | NSBRI, Texas A&M            | Ph.D., Principal  |
| 53 |              | University, TX              | Investigator      |
|    | L. Braby     |                             |                   |
|    |              | "                           | Ph.D.,            |
|    | N. Turner    |                             | Co-Investigator   |
|    |              | "                           |                   |
|    | S. Taddeo    |                             | Ph.D.,            |
|    |              | "                           | Co-Investigator   |
|    | N. Popovic   |                             |                   |
|    |              | "                           | Co-Worker         |
|    | M. Young     |                             |                   |
|    | Hong         | "                           | Co-Worker         |
|    |              |                             |                   |
|    | C. Henderson | "                           | Co-Worker         |
|    |              |                             |                   |
|    | L. Sanders   | "                           | Co-Worker         |
|    |              |                             |                   |
|    | J. Ford      | "                           | BS, Co-Worker     |
|    |              |                             |                   |
|    |              |                             | Ph.D., Co-Worker  |
+----+--------------+-----------------------------+-------------------+
| B- | A. Kennedy   | NSBRI, University of        | Ph.D., Principal  |
| 54 |              | Pennsylvania                | Investigator      |
|    | S. Wan       |                             |                   |
|    |              | "                           | Ph.D.,            |
|    | J. Ware      |                             | Co-Investigator   |
|    |              | "                           |                   |
|    | J. Donahue   |                             | Ph.D.,            |
|    |              | "                           | Co-Investigator   |
|    | M.           |                             |                   |
|    | Stanislaus   | "                           | Ph.D.,            |
|    |              |                             | Co-Investigator   |
|    |              |                             |                   |
|    |              |                             | Ph.D.,            |
|    |              |                             | Co-Investigator   |
+----+--------------+-----------------------------+-------------------+
|    |              |                             |                   |
+----+--------------+-----------------------------+-------------------+
|    |              |                             |                   |
+----+--------------+-----------------------------+-------------------+
|    |              |                             |                   |
+----+--------------+-----------------------------+-------------------+
| B- | J. Koniarek  | Columbia University, New    | Ph.D., Principal  |
| 57 |              | York, NY                    | Investigator      |
|    | M. Vazquez   |                             |                   |
|    |              | Brookhaven National         | Ph.D., MD,        |
|    |              | Laboratory, NY              | Co-Worker.        |
+----+--------------+-----------------------------+-------------------+
| B- | A. Obenaus   | Loma Linda University       | Ph.D., Principal  |
| 62 |              |                             | Investigator      |
|    | W. Kennedy   | "                           |                   |
|    |              |                             | Ph.D., Co-Worker  |
|    | T. Loring    | "                           |                   |
|    | Meir         |                             | Ph.D., Co-Worker  |
+----+--------------+-----------------------------+-------------------+
| B- | G. Nelson    | Loma Linda University       | Ph.D., Principal  |
| 63 |              |                             | Investigator      |
|    | > M. Pecaut  | "                           |                   |
|    |              |                             | Ph.D., Co-Worker  |
|    | A. Smith     | "                           |                   |
|    |              |                             | BS, Co-Worker     |
|    | S. Jones     | "                           |                   |
|    |              |                             | BS, Co-Worker     |
|    | S. Rainer    | "                           |                   |
|    |              |                             | BS, Co-Worker     |
+----+--------------+-----------------------------+-------------------+
| B- | M. Vazquez   | NSBRI, Brookhaven National  | MD, Ph.D.,        |
| 64 |              | Laboratory, NY              | Principal Invest. |
|    | L. Estevez   |                             |                   |
|    |              | "                           | BS, Co-Worker     |
|    | S. Otto      |                             |                   |
|    |              | "                           | BS, Co-Worker.    |
|    | O. Thomas    |                             |                   |
|    |              | "                           | BS, Co-Worker     |
+----+--------------+-----------------------------+-------------------+
| B- | M. Vazquez   | NSBRI, Brookhaven National  | MD, Ph.D.,        |
| 65 |              | Laboratory, NY              | Principal Invest. |
|    | O. Thomas    |                             |                   |
|    |              | "                           | BS, Co-Worker     |
|    | M. Bruneus   |                             |                   |
|    |              | "                           | BS, Co-Worker.    |
|    | A. Billups   |                             |                   |
|    |              | "                           | Undergrad-Student |
|    | S. Koslovsky |                             |                   |
|    |              | "                           | Undergrad-Student |
+----+--------------+-----------------------------+-------------------+
| B- | E. Hall\*    | CRR, Columbia University,   | Ph.D., Principal  |
| 68 |              | NY                          | Investigator      |
|    | B. Worgul    |                             |                   |
|    |              | ERERL, Columbia University, | Ph.D.,            |
|    | M. Vazquez   | NY                          | Co-Principal      |
|    |              |                             |                   |
|    | S. Otto      | Brookhaven National         | MD, Ph.D.,        |
|    |              | Laboratory, NY              | Co-Worker         |
|    |              |                             |                   |
|    |              | "                           | BS, Co-Worker.    |
+----+--------------+-----------------------------+-------------------+
| B- | G. Nelson    | Loma Linda University       | Ph.D., Principal  |
| 69 |              |                             | Investigator      |
|    | > M. Pecaut  | "                           |                   |
|    |              |                             | Ph.D., Co-Worker  |
|    | A. Smith     | "                           |                   |
|    |              |                             | BS, Co-Worker     |
|    | S. Jones     | "                           |                   |
|    |              |                             | BS, Co-Worker     |
+----+--------------+-----------------------------+-------------------+
| B- | F. Burns     | New York University Medical | Ph.D., Principal  |
| 71 |              | Center, NY                  | Investigator      |
|    | J. Xu        |                             |                   |
|    |              | "                           | Co-Worker         |
+----+--------------+-----------------------------+-------------------+
| B- | S. Gonda     | NASA, Johnson Space Center, | Ph.D., Principal  |
| 72 |              | TX                          | Investigator      |
+----+--------------+-----------------------------+-------------------+
| B- | B.           | Brookhaven National         | Ph.D., Principal  |
| 73 | Sutherland   | Laboratory, NY              | Investigator      |
|    |              |                             |                   |
|    | P. Bennett   | "\                          | MS., Biology      |
|    |              | "\                          | Associate.        |
|    | J.           | "\                          |                   |
|    | Sutherland   | "\                          | Ph.D., Co-Worker  |
|    |              | "                           |                   |
|    | M. Hada      |                             | Ph.D., Co-Worker  |
|    |              |                             |                   |
|    | J. Trunk     |                             | Co-Worker         |
|    |              |                             |                   |
|    | D.           |                             | Co-Worker         |
|    | Monteleone   |                             |                   |
+----+--------------+-----------------------------+-------------------+
| B- | A.           | Lawrence Berkeley National  | Ph.D., Principal  |
| 74 | Chatterjee\* | Laboratory, CA              | Investigator      |
|    |              |                             |                   |
|    | P. Wilson    |                             | Co-Worker         |
+----+--------------+-----------------------------+-------------------+
| B- | J. Ford      | Texas A&M University, TX    | Ph.D., Principal  |
| 75 |              |                             | Investigator      |
|    | L. Braby     | "                           |                   |
|    |              |                             | Ph.D.,            |
|    | T. Good      | "                           | Co-Investigator   |
|    |              |                             |                   |
|    | A. Houck     | "                           | Co-Worker         |
|    |              |                             |                   |
|    |              |                             | Co-Worker         |
+----+--------------+-----------------------------+-------------------+
| B- | L. Green     | Loma Linda University       | Ph.D., Principal  |
| 76 |              |                             | Investigator      |
|    | B. Bianski   | "                           |                   |
|    |              |                             | Co-Worker         |
+----+--------------+-----------------------------+-------------------+

**\*Not present during the actual run**

[**BNL-9** **PARTICIPANTS STATISTICS**]{.underline}

![](media/image3.wmf)

**[RESEARCH PROJECT SPONSORS:]{.underline}**

**[Participant Institutions]{.underline}**

**[NASA related centers/institutes]{.underline} (3)**

-   **NASA, Headquarters, DC**

-   **NASA, Johnson Space Center, TX**

-   **National Space Biomedical Research Institute, TX**

**[National Laboratories/Institutes]{.underline} (3)**

-   **Brookhaven National Laboratory, NY**

-   **Lawrence Berkeley National Laboratory, CA**

-   **Human Nutrition Research Center on Aging, MA**

**[Universities]{.underline} (8)**

-   **University of Maryland, Baltimore County, MD**

-   **Columbia University, NY**

-   **The University of Texas Health Sciences., TX**

-   **New York University Medical Center, NY**

-   **Loma Linda University, CA**

-   **Texas A&M University, TX**

-   **University of California, San Francisco, CA**

-   **University of Pennsylvania, PA**

**[Foreign Institutions]{.underline} (4)**

-   **University of Rome, Thor Vergara, Italy**

-   **University "Federico II", Napoli, Italy**

-   **National Institute of Health, Rome, Italy**

-   **University of Tokyo, Japan**

![](media/image4.wmf)

**INSTITUTIONS STATISTICS:**

# 

# 

# [BNL-9 IRON RUN DESCRIPTION]{.underline}

# RUN DATES

  ----------------------------------- --------------- ---------- ------------ ----------
  **Run dates**                       **Scheduled**              **Actual**   

                                      **Date**        **Time**   **Date**     **Time**

  **Run start**                       **11/07**       **0700**   **11/07**    **0700**

  **Run end**                         **11/14**       **0600**   **11/15**    **0200**

                                                                              

  **Tuned into cave**                 **11/06**       **0900**   **11/06**    **0900**

                                                                              

  **Beam delivered for Biology**                                              

  **Fe 5 GeV/n**                      **11/08**       **0600**   **11/08**    **0730**

  **End run**                         **11/10**       **0500**   **11/10**    **1600**

  **Fe 1 GeV/n**                      **11/10**       **2200**   **11/11**    **1100**

  **End run**                         **11/14**       **0730**   **11/15**    **0200**

  **Beam delivered for Physics**                                              

  **Fe 5 GeV/n**                      **11/7**        **0700**   **11/7**     **0700**

  **End run**                         **11/7**        **2300**   **11/7**     **2300**

  **Fe 1 GeV/n**                      **11/10**       **1000**   **11/10**    **2300**

  **End run**                         **11/10**       **2200**   **11/11**    **0800**
  ----------------------------------- --------------- ---------- ------------ ----------

**Beam Time Description (hours)**

+-------------------------+------------------+---------------+--------+
| **Total Clock Time**    | **(from 11/07    |               | *      |
|                         | 0700 to 11/15    |               | *187** |
|                         | 0200)**          |               |        |
+-------------------------+------------------+---------------+--------+
| **Total Beam-on Time**  |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **5 GeV/n**             | **79**           |               |        |
+-------------------------+------------------+---------------+--------+
| **1 GeV/n**             | **83.5**         |               |        |
+-------------------------+------------------+---------------+--------+
| **Sub-total**           |                  |               | **1    |
|                         |                  |               | 62.5** |
+-------------------------+------------------+---------------+--------+
| **Total Beam-off time** |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **5 GeV/n**             | **7.5**          |               |        |
+-------------------------+------------------+---------------+--------+
| **1 GeV/n**             | **17**           |               |        |
+-------------------------+------------------+---------------+--------+
| **Sub-total**           |                  |               | **     |
|                         |                  |               | 24.5** |
+-------------------------+------------------+---------------+--------+
| **Total**               |                  |               | **1    |
|                         |                  |               | 87.0** |
+-------------------------+------------------+---------------+--------+
| **Beam Time for         |                  |               |        |
| Biology**               |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **5 GeV/n In Vitro      | **30.5**         |               |        |
| Studies**               |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **5 GeV/n In Vivo       | **30**           |               |        |
| Studies**               |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Sub Totals**          |                  | **60.5**      |        |
+-------------------------+------------------+---------------+--------+
| **1 GeV/n In Vivo       | **18**           |               |        |
| Studies**               |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **1 GeV/n In Vivo       | **30**           |               |        |
| Studies**               |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Sub Totals**          |                  | **48**        |        |
+-------------------------+------------------+---------------+--------+
| **Total**               |                  |               | **1    |
|                         |                  |               | 08.5** |
+-------------------------+------------------+---------------+--------+
|                         |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Beam Time for         |                  |               |        |
| Physics**               |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **5 GeV/n**             | **16**           |               |        |
+-------------------------+------------------+---------------+--------+
| **1 GeV/n**             | **9**            |               |        |
+-------------------------+------------------+---------------+--------+
| **Sub-total**           |                  | **25**        |        |
+-------------------------+------------------+---------------+--------+
| > **Total**             |                  |               | **25** |
+-------------------------+------------------+---------------+--------+
|                         |                  |               |        |
+-------------------------+------------------+---------------+--------+
|                         |                  |               |        |
+-------------------------+------------------+---------------+--------+
| > **(Continuation)**    |                  |               |        |
+-------------------------+------------------+---------------+--------+
| > **Other**             |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **5 GeV/n**             |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Tuning-Dosimetry**    | **2.5**          |               |        |
+-------------------------+------------------+---------------+--------+
| **NSRL Testing**        | **7**            |               |        |
+-------------------------+------------------+---------------+--------+
| **Beam                  | **5**            |               |        |
| Chracaterization**      |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Sub-total**           |                  | **14.5**      |        |
+-------------------------+------------------+---------------+--------+
| **1 GeV/n**             |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Tuning-Dosimetry**    | **14.5**         |               |        |
+-------------------------+------------------+---------------+--------+
| **Sub-total**           |                  | **14.5**      |        |
+-------------------------+------------------+---------------+--------+
| **Total**               |                  |               | **29** |
+-------------------------+------------------+---------------+--------+
| **Grand Total**         |                  |               | **1    |
|                         |                  |               | 62.5** |
+-------------------------+------------------+---------------+--------+

# [BNL-9 SILICON RUN DESCRIPTION]{.underline}

# RUN DATES

  ----------------------------------- --------------- ---------- ------------ ----------
  **Run dates**                       **Scheduled**              **Actual**   

                                      **Date**        **Time**   **Date**     **Time**

  **Run start**                       **11/14**       **0730**   **11/15**    **0200**

  **Run end**                         **11/15**       **1000**   **11/16**    **0400**

                                                                              

  **Tuned into cave**                 **11/14**       **0730**   **11/15**    **0200**

                                                                              

  **Beam delivered for Biology**                                              

  **Si 0.6 GeV/n**                    **11/14**       **1900**   **11/15**    **1000**

  **End run**                         **11/15**       **1000**   **11/16**    **0230**

  **Beam delivered for beam testing**                                         

  **Si 1 GeV/n**                                                 **11/16**    **0230**

  **End run**                                                    **11/16**    **0400**
  ----------------------------------- --------------- ---------- ------------ ----------

**Beam Time Description (hours)**

+-------------------------+------------------+---------------+--------+
| **Total Clock Time**    | **(from 11/15    |               | **26** |
|                         | 0200 to 11/16    |               |        |
|                         | 0400)**          |               |        |
+-------------------------+------------------+---------------+--------+
|                         |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Total Beam-on Time**  |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **0.6 GeV/n**           | **22**           |               |        |
+-------------------------+------------------+---------------+--------+
| **Total Beam-off time** |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **0.6 GeV/n**           | **4**            |               |        |
+-------------------------+------------------+---------------+--------+
| **Total**               |                  |               | **26** |
+-------------------------+------------------+---------------+--------+
| **Beam Time for         |                  |               |        |
| Biology**               |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **0.6 GeV/n In Vitro    | **12.5**         |               |        |
| Studies**               |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **0.6 GeV/n In Vivo     | **0**            |               |        |
| Studies**               |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Sub Totals**          |                  |               | **     |
|                         |                  |               | 12.5** |
+-------------------------+------------------+---------------+--------+
|                         |                  |               |        |
+-------------------------+------------------+---------------+--------+
|                         |                  |               |        |
+-------------------------+------------------+---------------+--------+
|                         |                  |               |        |
+-------------------------+------------------+---------------+--------+
|                         |                  |               |        |
+-------------------------+------------------+---------------+--------+
|                         |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **(Continuation)**      |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Beam Time for         |                  |               |        |
| Physics**               |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **0.6 GeV/n**           | **0**            |               |        |
+-------------------------+------------------+---------------+--------+
| **Sub-total**           |                  |               | **0**  |
+-------------------------+------------------+---------------+--------+
| > **Other**             |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **0.6 GeV/n**           |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Tuning-Dosimetry**    | **8**            |               |        |
+-------------------------+------------------+---------------+--------+
| **NSRL Testing**        | **1.5**          |               |        |
+-------------------------+------------------+---------------+--------+
| **Beam                  | **0**            |               |        |
| Chracaterization**      |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Sub-total**           |                  |               | *      |
|                         |                  |               | *9.5** |
+-------------------------+------------------+---------------+--------+
| **Grand Total**         |                  |               | **22** |
+-------------------------+------------------+---------------+--------+

BNL-9 FINAL RUN DATES

  ----------------------------------- --------------- ---------- ------------ ----------
  **Run dates**                       **Scheduled**              **Actual**   

                                      **Date**        **Time**   **Date**     **Time**

  **Run start**                       **11/07**       **0700**   **11/07**    **0700**

  **Run end**                         **11/15**       **1000**   **11/16**    **0400**

                                                                              

  **Tuned into cave**                 **11/06**       **0900**   **11/06**    **0900**

                                                                              
  ----------------------------------- --------------- ---------- ------------ ----------

**[total BNL-9 Beam Time Description (hours)]{.underline}**

+-------------------------+------------------+---------------+--------+
| **Total Clock Time**    | **(from 11/07    |               | *      |
|                         | 0700 to 11/16    |               | *213** |
|                         | 0400)**          |               |        |
+-------------------------+------------------+---------------+--------+
|                         |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Total Beam-on Time**  |                  |               | **1    |
|                         |                  |               | 84.5** |
+-------------------------+------------------+---------------+--------+
|                         |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Total Beam-off time** |                  |               | **     |
|                         |                  |               | 28.5** |
+-------------------------+------------------+---------------+--------+
|                         |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Beam Time for         |                  |               |        |
| Biology**               |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **In Vivo Studies**     | **48**           |               |        |
+-------------------------+------------------+---------------+--------+
| **In Vitro Studies**    | **73**           |               |        |
+-------------------------+------------------+---------------+--------+
|                         |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Beam Time for         | **25**           |               |        |
| Physics**               |                  |               |        |
+-------------------------+------------------+---------------+--------+
|                         |                  |               |        |
+-------------------------+------------------+---------------+--------+
| > **Beam time for       | **38.5**         |               |        |
| > dosimetry,            |                  |               |        |
| > calibration, tuning,  |                  |               |        |
| > etc.**                |                  |               |        |
+-------------------------+------------------+---------------+--------+
|                         |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Totals**              | **184.5**        |               | *      |
|                         |                  |               | *213** |
+-------------------------+------------------+---------------+--------+

![](media/image5.wmf)**[Descriptive statistics]{.underline}**

-   **fe Total Beam Availability**

> ![](media/image6.wmf)

-   **Fe 5 GeV/n • Fe 1 GeV/n**

```{=html}
<!-- -->
```
-   ![](media/image8.wmf) **Si Total Beam Availability**

-   ![](media/image9.wmf)**Fe 5 GeV/n Distribution of Beam Time Usage:**

![](media/image10.wmf)

# ![](media/image11.wmf)Fe 1 GeV/n Distribution of Beam Time Usage:

# 

# 

# 

# ![](media/image12.wmf)Si 0.6 GeV/n Distribution of Beam Time Usage:

# 

# 

# 

# 

# 

# 

# 

# 

# ![](media/image13.wmf)

# 

# Si 0.6 GeV/n Distribution of Beam Time for Biology:

# 

# 

# 

# 

# 

# 

# 

# 

# 

# 

#  

# [BNL-9 BEAM TIME SUMMARY]{.underline}

![](media/image14.wmf)

# DISTRIBUTION OF BEAM TEAM USAGE:

# ![](media/image15.wmf)DISTRIBUTION OF BEAM TEAM BY SPECIES AND ENERGIES:

# DISTRIBUTION OF TOTAL BEAM TIME BY BIOLOGY EXPERIMENTS:

# ![](media/image16.wmf)  {#section-26 .unnumbered}

# [BEAM CHARACTERISTICS]{.underline}

+---------------------------+-------------+-------------+-------------+
|                           | **^         |             | **^         |
|                           | 56^Fe^26^** |             | 28^Si^14^** |
+---------------------------+-------------+-------------+-------------+
|                           | **5000      | **1000      | **600       |
|                           | MeV/n**     | MeV/n**     | MeV/n**     |
+---------------------------+-------------+-------------+-------------+
| **Fluence                 | **TBD**     | **1 x       | **TBD**     |
| (particles/cm^2^/sec)**   |             | 10^8^**     |             |
|                           | **400**     |             | **400**     |
| **Maximum on target**     |             | **400**     |             |
|                           |             |             |             |
| **Minimum on target**     |             |             |             |
+---------------------------+-------------+-------------+-------------+
| **Spill rate              | **18**      | **18**      | **18**      |
| (spills/min)**            |             |             |             |
+---------------------------+-------------+-------------+-------------+
| **Spill length (msec)**   | **500-600** | **500-600** | **500-600** |
+---------------------------+-------------+-------------+-------------+
| **Particles/spill**       | **1 x       | **1 x       | **1 x       |
|                           | 10^8^**     | 10^8^**     | 10^8^**     |
| > **Maximum**             |             |             |             |
|                           | **1.5 x     | **1.5 x     | **1.5 x     |
| #### Minimum              | 10^5^**     | 10^5^**     | 10^5^**     |
+---------------------------+-------------+-------------+-------------+
| **Beam spot diameter      | **7.5**     | **7.5 - 9** | **7.5**     |
| (cm)**                    |             |             |             |
+---------------------------+-------------+-------------+-------------+
| **Beam cut off length.**  | **\<1%**    | **\<1%**    | **\<1%**    |
+---------------------------+-------------+-------------+-------------+
| **Actual Energy (MeV/n)** | ###### TBD  | **1078**    | ###### 600  |
|                           |             |             |             |
| ##### Extracted           | **TBD**     | **1046**    | **585**     |
|                           |             |             |             |
| > **On Target**           |             |             |             |
+---------------------------+-------------+-------------+-------------+
| **Actual LET on Target    | **143**     | **148**     | **49.5**    |
| (keV/µm)**                |             |             |             |
+---------------------------+-------------+-------------+-------------+
| **Dose/rate recorded      | **1500**    | **1500**    | **1000**    |
| (cGy/min)**               |             |             |             |
|                           | **10**      | **10**      | **10**      |
| **Maximum**               |             |             |             |
|                           |             |             |             |
| **Minimum**               |             |             |             |
+---------------------------+-------------+-------------+-------------+
| **Minimum dose exposure   | **5**       | **0.1**     | **TBD**     |
| (cGy)**                   |             |             |             |
+---------------------------+-------------+-------------+-------------+
| **No of hours for beam    | **14.5**    | **14.5**    | **9.5**     |
| characterization,         |             |             |             |
| tuning**                  |             |             |             |
|                           |             |             |             |
| **and dosimetry**         |             |             |             |
+---------------------------+-------------+-------------+-------------+

BNL-9 Run Statistics and Incidents

+--------+----+--------+--------+-------------------------------------+
| **     | *  | **HIP  | *      | **Remarks**                         |
| Date** | *S | Av     | *Non-H |                                     |
|        | hi | ail.** | IP\*** |                                     |
|        | ft |        |        |                                     |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
| **11/0 | *  | **8**  | **0**  | **5 GeV Fe run start, dosimetry.    |
| 7/02** | *1 |        |        | Physics experiments**               |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
|        | *  | **8**  | **0**  | **Physics continues.**              |
|        | *2 |        |        |                                     |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
|        | *  | **8**  | **0**  | **Physic run end. BAF testing       |
|        | *3 |        |        | start.**                            |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
| **11/0 | *  | **8**  | **0**  | **Test completed. Dosimetry for     |
| 8/02** | *4 |        |        | biology start.**                    |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
|        | *  | **7**  | **1**  | **Biology run start. Iris scan      |
|        | *5 |        |        | hardware problems.**                |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
|        | *  | **6**  | **2**  | **Same problems. High dose rate     |
|        | *6 |        |        | tuning.**                           |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
| **11/0 | *  | **6**  | **2**  | ## Security syst                    |
| 9/02** | *7 |        |        | em fault and beam control problems. |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
|        | *  | **8**  | **0**  | **Biology run continues. No         |
|        | *8 |        |        | incidents.**                        |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
|        | *  | **8**  | **0**  | **Biology run continues. No         |
|        | *9 |        |        | incidents.**                        |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
| **11/1 | ** | **8**  | **0**  | **Biology run continues. No         |
| 0/02** | 10 |        |        | incidents.**                        |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
|        | ** | *      | *      | **Power supply problems. Intensity  |
|        | 11 | *5.5** | *2.5** | lost, foil change.**                |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
|        | ** | **8**  | **0**  | **Switch to 1 GeV/n Fe, dosimetry,  |
|        | 12 |        |        | tuning low intensity**              |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
| **11/1 | ** | **8**  | **0**  | **Physics run.**                    |
| 1/02** | 13 |        |        |                                     |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
|        | ** | **8**  | **0**  | **Biology run start**               |
|        | 14 |        |        |                                     |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
|        | ** | **5**  | **3**  | **Intensity fluctuations. F6 septum |
|        | 15 |        |        | trip-off**                          |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
| **11/1 | ** | *      | *      | **Beam drifting. Biology            |
| 2/02** | 16 | *4.5** | *3.5** | continues.**                        |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
|        | ** | **8**  | **0**  | **No incidents**                    |
|        | 17 |        |        |                                     |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
|        | ** | *      | *      | **Beam control problems. Vacuum     |
|        | 18 | *4.5** | *3.5** | valve problems**                    |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
| **11/1 | ** | **6**  | **6**  | **Septum off. Retuning.**           |
| 3/02** | 19 |        |        |                                     |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
|        | ** | **8**  | **0**  | **No incidents.**                   |
|        | 20 |        |        |                                     |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
|        | ** | **6**  | **2**  | **Beam control lost.**              |
|        | 21 |        |        |                                     |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
| **11/1 | ** | **8**  | **0**  | ##  No incidents.                   |
| 4/02** | 22 |        |        |                                     |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
|        | ** | **8**  | **0**  | ## No incidents.                    |
|        | 23 |        |        |                                     |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
|        | ** | *      | *      | **Beam drifting.**                  |
|        | 24 | *7.5** | *0.5** |                                     |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
| **11/1 | ** | *      | *      | **Idem. Switch to 0.6 GeV/n Si for  |
| 5/02** | 25 | *6.5** | *1.5** | biology**                           |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
|        | ** | **4**  | **4**  | **Booster problems.**               |
|        | 26 |        |        |                                     |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
|        | ** | **8**  | **0**  | **No incidents.**                   |
|        | 27 |        |        |                                     |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
| **11/1 | ** | **8**  | **0**  | **End BNL-9.**                      |
| 6/02** | 28 |        |        |                                     |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
|        |    |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
| **Tot  | ** | *      | **31.5 |                                     |
| als:** | 28 | *196.5 | hr.    |                                     |
|        | ** | hr.    | (      |                                     |
|        |    | (      | 16%)** |                                     |
|        |    | 84%)** |        |                                     |
+--------+----+--------+--------+-------------------------------------+

**\*Time loss due to machine or power supply problems, setting up
operations.**

![](media/image17.wmf){width="6.625in" height="5.48125in"}

**BNL-9 EXPERIMENTERS AND RUN STATISTICS**

+------+----------+---------+-------+------+--------+-------+-------+
| **   | **P      | **Ion & | *     | **   | **Dose | *     | **N   |
| Exp. | rincipal | E       | *Beam | Beam | Range  | *Dose | umber |
| ID** | Invest   | nergy** | T.    | T.   | (      | /Rate | of    |
|      | igator** |         | Appro | Us   | cGy)** | (     | Samp  |
|      |          |         | ved** | ed** |        | cGy/m | les** |
|      |          |         |       |      |        | in)** |       |
+------+----------+---------+-------+------+--------+-------+-------+
| B-1  | Zeitlin  | Fe, 5   | 16.0  | 16.0 | NA     | NA    | NA    |
|      |          | GeV/n   |       |      |        |       |       |
|      |          |         | 12.0  | 8.0  |        |       |       |
|      |          | Fe, 1   |       |      |        |       |       |
|      |          | GeV/n   |       |      |        |       |       |
+------+----------+---------+-------+------+--------+-------+-------+
| B-3  | Cuci     | Fe, 5   | 2.0   | 3.5  | 25 to  | 50 to | 90    |
|      | notta/Wu | GeV/n   |       |      | 200    | 100   |       |
|      |          |         | 2.0   | 2.0  |        |       |       |
|      |          | Fe, 1   |       |      |        |       |       |
|      |          | GeV/n   |       |      |        |       |       |
+------+----------+---------+-------+------+--------+-------+-------+
| B-7  | Rabin    | Fe, 5   | 5.0   | 6.5  | 80 to  | 100   | 86    |
|      |          | GeV/n   |       |      | 250    |       |       |
|      |          |         | 6.5   | 6.5  |        | 200   | 90    |
|      |          | Fe, 1   |       |      | 100 to |       |       |
|      |          | GeV/n   |       |      | 250    |       |       |
+------+----------+---------+-------+------+--------+-------+-------+
| B-44 | Durante  | Fe, 5   | 8.0   | 9.5  | 10 to  | 10 &  | 300   |
|      |          | GeV/n   |       |      | 20000  | 1500  |       |
|      |          |         | 3.0   | 4.5  |        |       |       |
|      |          | Fe, 1   |       |      |        |       |       |
|      |          | GeV/n   |       | 1.5  |        |       |       |
|      |          | Si, 0.6 |       |      |        |       |       |
|      |          | GeV/n   |       |      |        |       |       |
+------+----------+---------+-------+------+--------+-------+-------+
| ##   | Setlow   | Fe, 1   | 1.5   | 2.5  | 30 to  | 100   | 70    |
| B-45 |          | GeV/n   |       |      | 100    |       |       |
+------+----------+---------+-------+------+--------+-------+-------+
| B-51 | Murnane  | Fe, 1   | 3.0   | 2.0  | 100 to | 200   | 20    |
|      |          | GeV/n   |       |      | 800    |       |       |
+------+----------+---------+-------+------+--------+-------+-------+
| B-52 | Gerwitz  | Fe, 5   | 2.5   | 3.5  | 35 to  | 20 &  | 100   |
|      |          | GeV/n   |       |      | 200    | 100   |       |
|      |          |         | 2.5   | 5.0  |        |       | 100   |
|      |          | Fe, 1   |       |      | 35 to  | 20 &  |       |
|      |          | GeV/n   |       | 5.0  | 200    | 100   |       |
|      |          | Si, 0.6 |       |      |        |       |       |
|      |          | GeV/n   |       |      | NA     | NA    |       |
+------+----------+---------+-------+------+--------+-------+-------+
| B-53 | Lupton   | Fe, 1   | 6.5   | 5.0  | 100    | 100   | 75    |
|      |          | GeV/n   |       |      |        |       |       |
+------+----------+---------+-------+------+--------+-------+-------+
| B-54 | Kennedy  | Fe, 5   | 12.0  | 10.0 | 5 to   | 10 to | 200   |
|      |          | GeV/n   |       |      | 200    | 100   |       |
|      |          |         | 2.0   | 0.0  |        |       |       |
|      |          | Fe, 1   |       |      |        |       |       |
|      |          | GeV/n   |       | 3.0  |        |       |       |
|      |          | Si, 0.6 |       |      |        |       |       |
|      |          | GeV/n   |       |      |        |       |       |
+------+----------+---------+-------+------+--------+-------+-------+
| B-57 | Koniarek | Fe, 1   | 0.0   | 0.0  | NA     | NA    | 30    |
|      |          | GeV/n   |       |      |        |       |       |
+------+----------+---------+-------+------+--------+-------+-------+
| ##   | Obenaus  | Fe, 5   | 7.0   | 5.5  | 100 to | 100   | 110   |
| B-62 |          | GeV/n   |       |      | 400    |       |       |
|      |          |         |       | 2.0  |        |       |       |
|      |          | Fe, 1   |       |      |        |       |       |
|      |          | GeV/n   |       |      |        |       |       |
+------+----------+---------+-------+------+--------+-------+-------+
| B-63 | Nelson   | Fe, 5   | 1.0   | 3.5  | 200 &  | 10    | 20    |
|      |          | GeV/n   |       |      | 1000   | 0-200 |       |
|      |          |         | 2.0   | 2.5  |        |       | 60    |
|      |          | Fe, 1   |       |      |        |       |       |
|      |          | GeV/n   |       |      |        |       |       |
+------+----------+---------+-------+------+--------+-------+-------+
| B-64 | Vazquez  | Fe, 1   | 6.5   | 6.0  | 15 to  | 50 to | 200   |
|      |          | GeV/n   |       |      | 240    | 150   |       |
+------+----------+---------+-------+------+--------+-------+-------+
| B-65 | Vazquez  | Fe, 5   | 6.0   | 5.0  | 15 to  | 50 to | 100   |
|      |          | GeV/n   |       |      | 200    | 150   |       |
|      |          |         | 7.0   | 7.5  |        |       | 100   |
|      |          | Fe, 1   |       |      | 15 to  | 50 to |       |
|      |          | GeV/n   |       | 3.0  | 200    | 150   | 100   |
|      |          |         |       |      |        |       |       |
|      |          | Si, 0.6 |       |      | 15 to  | 50 to |       |
|      |          | GeV/n   |       |      | 200    | 150   |       |
+------+----------+---------+-------+------+--------+-------+-------+
| ##   | Hal      | Fe, 1   | 2.5   | 3.0  | NA     | NA    | 50    |
| B-68 | l/Worgul | GeV/n   |       |      |        |       |       |
+------+----------+---------+-------+------+--------+-------+-------+
| ##   | Nelson   | Fe, 1   | 2.5   | 1.0  | 500 to | 100   | 100   |
| B-69 |          | GeV/n   |       |      | 5000   | to    |       |
|      |          |         |       |      |        | 1000  |       |
+------+----------+---------+-------+------+--------+-------+-------+
| B-71 | Burns    | Fe, 1   | 7.0   | 4.0  | 1 to   | 5     | 50    |
|      |          | GeV/n   |       |      | 300    | 0-100 |       |
+------+----------+---------+-------+------+--------+-------+-------+
| B-72 | Gonda    | Fe, 1   | 2.0   | 1.0  | 50 to  | 5     | 80    |
|      |          | GeV/n   |       |      | 200    | 0-100 |       |
+------+----------+---------+-------+------+--------+-------+-------+
| B-73 | Su       | Fe, 1   | 2.0   | 3.5  | 1 to   | 5     | 50    |
|      | therland | GeV/n   |       |      | 300    | 0-100 |       |
+------+----------+---------+-------+------+--------+-------+-------+
| B-74 | Ch       | Fe, 1   | 4.0   | 2.0  | 30 to  | 5     | 20    |
|      | atterjee | GeV/n   |       |      | 150    | 0-100 |       |
+------+----------+---------+-------+------+--------+-------+-------+
| B-75 | Ford     | Fe, 5   | 3.0   | 1.5  | 5 to   | 5     | 30    |
|      |          | GeV/n   |       |      | 10     |       |       |
+------+----------+---------+-------+------+--------+-------+-------+
| B-76 | Green    | Fe, 1   | 1.0   | 1.0  | 50 to  | 100   | 6     |
|      |          | GeV/n   |       |      | 200    |       |       |
+------+----------+---------+-------+------+--------+-------+-------+
| **   | **22**   |         | **138 | *    | **5 to | **20  | **\~2 |
| Tota |          |         | hr**  | *146 | 2      | to    | 237** |
| ls** |          |         |       | hr** | 0000** | 1     |       |
|      |          |         |       |      |        | 500** |       |
+------+----------+---------+-------+------+--------+-------+-------+

# BNL-9 PARTICIPANTS, EXPERIMENTAL SAMPLES AND ENDPOINTS

+----+--------------------+------------------+-------------------------+
| ** | **Participants**   | **Samples**      | **Endpoints**           |
| Ex |                    |                  |                         |
| p. |                    |                  |                         |
| ** |                    |                  |                         |
+----+--------------------+------------------+-------------------------+
| B  | Heavy Ion          | Solid state      | Heavy ion fragmentation |
| -1 | Fragmentation and  | detectors        |                         |
|    | Transport in       |                  | CR39 calibration        |
|    | Matter             |                  |                         |
|    |                    |                  |                         |
|    | **C. Zeitlin       |                  |                         |
|    | (PI)**             |                  |                         |
+----+--------------------+------------------+-------------------------+
| B  | Heavy Ion Induced  | Human lymphocyte | PCC chromosome damage   |
| -3 | Chromosome Damage  | and human        |                         |
|    | and Biomedical     | fibroblast       | Gene expression using   |
|    | Countermeasures    | (AG1522)         | SELDI Protein Chip      |
|    |                    |                  | System                  |
|    | **F. Cucinotta/H.  |                  |                         |
|    | Wu (PI)**          |                  |                         |
+----+--------------------+------------------+-------------------------+
| B  | Effects of         | Sprague-Dawley   | Neurological and        |
| -7 | Exposure to Heavy  | Rats             | neurochemical changes   |
|    | Ions.              |                  |                         |
|    |                    |                  |                         |
|    | **B. Rabin (PI)**  |                  |                         |
+----+--------------------+------------------+-------------------------+
| B- | Influence of the   | Human cells      | DNA damage and repair.  |
| 44 | Shielding on the   | embedded in      | Shielding effects.      |
|    | Space rad.         | agarose          |                         |
|    | Biological         | gel(plugs)       |                         |
|    | Effectiveness**.** |                  |                         |
|    |                    | Human            |                         |
|    | **M. Durante       | lymphocytes in   |                         |
|    | (PI)**             | suspension in    |                         |
|    |                    | full medium      |                         |
+----+--------------------+------------------+-------------------------+
| B- | Germ Cell          | Male Medaka fish | Mutation induction      |
| 45 | Mutagenesis in     |                  |                         |
|    | Medaka Fish        |                  |                         |
|    | Following Exposure |                  |                         |
|    | to HZE particle    |                  |                         |
|    | radiation          |                  |                         |
|    |                    |                  |                         |
|    | **R. Setlow (PI)** |                  |                         |
+----+--------------------+------------------+-------------------------+
| B- | Particle-Ind.      | SC308H cells     | Survival, mutation      |
| 51 | Telomere Loss in   |                  | frequency, chromosomal  |
|    | Human cells.       |                  | changes and telomere    |
|    |                    |                  | status.                 |
|    | **J. Murnane       |                  |                         |
|    | (PI)**             |                  |                         |
+----+--------------------+------------------+-------------------------+
| B- | Effect of Deep     | TF-1 cells       | DNA damage (DSB and     |
| 52 | Space Radiation on |                  | clustered damages)      |
|    | Human              |                  |                         |
|    | Hematopoietic Stem |                  |                         |
|    | Cells.             |                  |                         |
|    |                    |                  |                         |
|    | **A. Gerwitz       |                  |                         |
|    | (PI)**             |                  |                         |
+----+--------------------+------------------+-------------------------+
| B- | Nutritional        | Sprague-Dawley   | Gene expression, tumor  |
| 53 | Countermeasures to | rats             | incidence.              |
|    | Radiation          |                  |                         |
|    | Exposure.          |                  |                         |
|    |                    |                  |                         |
|    | **J. Lupton (PI)** |                  |                         |
+----+--------------------+------------------+-------------------------+
| B- | Screening of       | Sprague-Dawley   | Cell transformation.    |
| 54 | Agents for         | rats             |                         |
|    | Protection Against |                  | Measure of oxidative    |
|    | Radiation Induced  | Htori-3 human    | stress (DCF).           |
|    | Oxidative Stress   | thyroid cells    |                         |
|    |                    |                  | Antioxidant assays in   |
|    | **A. Kennedy       | 10T1/2 mouse     | collected tissues.      |
|    | (PI)**             | fibroblast cells |                         |
+----+--------------------+------------------+-------------------------+
| B- | Microlesions in    | Pho              | Florescence signal.     |
| 57 | Membranes Induced  | sphatidylcholine |                         |
|    | by Heavy Ion Rad.  | vesicles         |                         |
|    |                    | dye-filled       |                         |
|    | **J. Koniarek      |                  |                         |
|    | (PI)**             |                  |                         |
+----+--------------------+------------------+-------------------------+
| B- | Differential       | Sprague-Dawley   | Behavioral Testing:     |
| 62 | Cognitive,         | rats             | Radial Arm Maze and     |
|    | Behavioral, and    |                  | Morris Water Maze       |
|    | Biological Effects |                  |                         |
|    | of Protons and     |                  |                         |
|    | 56Fe Irradiatiion  |                  |                         |
|    | of the Rat Brain   |                  |                         |
|    |                    |                  |                         |
|    | **A. Obenaus       |                  |                         |
|    | (PI)**             |                  |                         |
+----+--------------------+------------------+-------------------------+
| B- | Radiation Induced  | C57Bl/6 Mice     | Gene Expression using   |
| 63 | Gene Expression    |                  | microarray analysis.    |
|    | Profile in C57Bl/6 |                  |                         |
|    | Mice               |                  |                         |
|    |                    |                  |                         |
|    | **G. Nelson (PI)** |                  |                         |
+----+--------------------+------------------+-------------------------+
| B- | Risk Assessment    | NT2 human neural | Survival, apoptosis,    |
| 64 | and                | stem cells,      | gene expression.        |
|    | Chemoprevention of | oligodendrocytes |                         |
|    | HZE-Induced CNS    |                  |                         |
|    | Damage             |                  |                         |
|    |                    |                  |                         |
|    | **M. Vazquez       |                  |                         |
|    | (PI)**             |                  |                         |
+----+--------------------+------------------+-------------------------+
| B- | CNS Damage and     | C57Bl/6 Mice     | Behavioral Testing:     |
| 65 | Countermeasure     |                  | Locomotor activity and  |
|    |                    |                  | Morris Water Maze.      |
|    | **M. Vazquez       |                  | Neurochemistry.         |
|    | (PI)**             |                  |                         |
+----+--------------------+------------------+-------------------------+
|    |                    |                  |                         |
+----+--------------------+------------------+-------------------------+
|    |                    |                  |                         |
+----+--------------------+------------------+-------------------------+
|    |                    |                  |                         |
+----+--------------------+------------------+-------------------------+
|    |                    |                  |                         |
+----+--------------------+------------------+-------------------------+
| ** | **Participants**   | **Samples**      | **Endpoints**           |
| Ex |                    |                  |                         |
| p. |                    |                  |                         |
| ** |                    |                  |                         |
+----+--------------------+------------------+-------------------------+
| B- | **Hall/Worgul      | C57Bl/6 wild     | Cataract induction      |
| 68 | (PI)**             | type mice        |                         |
|    |                    |                  |                         |
|    |                    | C57Ml/6 ATM      |                         |
|    |                    | mutant           |                         |
+----+--------------------+------------------+-------------------------+
| B- | Mutation &         | Nematode *C.     | Mutation and chromosome |
| 69 | Chromosome         | elegans*         | aberrations.            |
|    | Aberration in the  |                  |                         |
|    | Nematode *C.       |                  |                         |
|    | elegans* following |                  |                         |
|    | Irradiation with   |                  |                         |
|    | Relativistic       |                  |                         |
|    | Charged Particles  |                  |                         |
|    |                    |                  |                         |
|    | **G. Nelson (PI)** |                  |                         |
+----+--------------------+------------------+-------------------------+
| B- | Selective          | Sprague-Dawley   | Skin tumor induction    |
| 71 | Inhibition of 56Fe | Rats             | and modulation by       |
|    | carcinogenesis by  |                  | dietary retinyl         |
|    | Dietary Retinod    |                  | actetate.               |
|    |                    |                  |                         |
|    | **F. Burns (PI)**  |                  |                         |
+----+--------------------+------------------+-------------------------+
| B- | Comparison of Cell | Normal &         | Mutation types and      |
| 72 | and Tissue 3D      | Transgenic       | frequency induced in    |
|    | Models for         | fibroblast cells | target genes at         |
|    | Assessment of      |                  | molecular level.        |
|    | Genotoxic Damage   | Normal &         |                         |
|    | by High Energy     | Transgenic       |                         |
|    | Charged Particles. | epithelial cells |                         |
|    |                    |                  |                         |
|    | **S. Gonda (PI)**  |                  |                         |
+----+--------------------+------------------+-------------------------+
| B- | DNA Damage         | T7 and in Human  | ## Bistrande            |
| 73 | Clusters in low    | DNA              | d Clustered DNA Damages |
|    | level radiation    |                  |                         |
|    | responses of Human | human cells      |                         |
|    | Cells              | (28SC monocytes) |                         |
|    |                    |                  |                         |
|    | **B. Sutherland    |                  |                         |
|    | (PI)**             |                  |                         |
+----+--------------------+------------------+-------------------------+
| B- | Predicted and      | GM2149 Normal    | Chromosomal             |
| 74 | Observed           | human fibroblast | aberrations.            |
|    | Dose-responses for | cell cultures    |                         |
|    | Simple and Complex |                  |                         |
|    | Chromosomal        |                  |                         |
|    | Aberrations after  |                  |                         |
|    | Exposure of Human  |                  |                         |
|    | Cells to HZE       |                  |                         |
|    | Radiations:        |                  |                         |
|    | Effects of Beam    |                  |                         |
|    | Filtration.        |                  |                         |
|    |                    |                  |                         |
|    | **A. Chatterjee    |                  |                         |
|    | (PI)**             |                  |                         |
+----+--------------------+------------------+-------------------------+
| B- | Low dose response  | Tracheal tissue  | Apoptosis and bystander |
| 75 | of respiratory     | explants.        | effects                 |
|    | cells in intact    |                  |                         |
|    | tissue and         |                  |                         |
|    | reconstituted      |                  |                         |
|    | [tissue            |                  |                         |
|    | const              |                  |                         |
|    | ructs]{.underline} |                  |                         |
|    |                    |                  |                         |
|    | **J. Ford (PI)**   |                  |                         |
+----+--------------------+------------------+-------------------------+
| B- | Radiobiology of    | 3D Thyroid cells | Gene expression         |
| 79 | thyroid follicular | cultures         | alterations             |
|    | cells.             |                  |                         |
|    |                    |                  |                         |
|    | **L. Green (PI)**  |                  |                         |
+----+--------------------+------------------+-------------------------+

**List of personnel that participated in the planning, organization and
execution of BNL-8 run**

**[BNL Management:]{.underline}**

-   Laboratory Director: **Peter Paul**

-   Associate Director for High Energy and Nuclear Physics**: Tom Kirk**

-   Associate Laboratory Director for Life Sciences: **Nora Volkow**

**[NASA Management:]{.underline}**

-   Headquarters: **Walter Schimmerling**

-   JSC: **Frank Cucinotta**

**[Scientific Advisory Committee:]{.underline}**

-   **Betsy Sutherland** (Chair), BNL

-   **Louis Pena,** BNL

-   **Richard Setlow,** BNL

-   **Joel Bedford,** CSU

-   **Les Braby,** PNL

-   **Charles Geard,** Columbia University

-   **Kathryn Held,** Massachusetts General Hospital

**[Collider Accelerator Department-AGS]{.underline}**

-   Chairman: **Derek Lowenstein**

-   Deputy Chairman: [**W.T.
    Weng**](http://www.ccd.bnl.gov/cgi-bin/ph/ns.bnl.gov?alias%3Dweng)

-   Associate Chair of Operations: [**A.J.
    McNerney**](http://www.ccd.bnl.gov/cgi-bin/ph/ns.bnl.gov?mcnerney)

-   Experimental Planning and Support Head: **Philip Pile**

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-   Associate Chair for ESHQ: ** Ed Lessard**

-   ESHQ Division Head: **Ray Karol** ** **

-   ESH Coordinator: ** Asher Etkin** ** **

-   Facility Support Representative: **Chuck Schaefer / Henry
    Kahnhauser **

-   Environmental Coordinator: **Joel Scott** ** **

-   Training and Procedures Manager : **John Maraviglia** ** **

-   Main Control Room: **Peter Ingrassia** ** **

-   Work Control Manager: **Peter Cirnigliaro** ** **

-   BNL Laser Safety Officer: **Chris Weilandics** ** **

-   Experimental Safety Review Committee: **Yousef Makdisi (Chair)**
    ** **

-   Radiation Safety Committee: **Dana Beavis (Chair)** ** **

-   **Acc**elerator Safety Review Committee: **Woody Glenn (Chair)**
    ** **

-   ALARA Committee: **Chuck Schaefer (Chair**

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-   Associate Chair for ES&H/Q.A: [**E.
    Lessard**](http://www.ccd.bnl.gov/cgi-bin/ph/ns.bnl.gov?alias%3Dlessard)

-   Accelerator Division Head: **Thomas Roser**

-   Chief Electrical Engineer: [**J.
    Sandberg**](http://www.ccd.bnl.gov/cgi-bin/ph/ns.bnl.gov?alias%3Djsandberg)

-   Chief Mechanical Engineer: [**J.
    Tuozzolo**](http://www.ccd.bnl.gov/cgi-bin/ph/ns.bnl.gov?tuozzolo)

-   Accelerator Physicist lead by: **Leif Aherns**

-   Tanden Group leader: **Peter Thieberger**

-   Physics Support: **Yusef Makadisi**

-   CAD Components and instrumentation support: **David Gassner**

-   AGS Radiation Safety Committee: **Ken Reece**

-   C-A Dept Training Manager: **John Maraviglia**

-   AGS Control Section lead by: **Don Barton**

-   Liaison Engineering Group lead by: **David Phillips**

-   Liaison physicist: **Adam Rusek**

-   RHIC&AGS Users Center: **Susan White-DePace, Angela Melocoton**

-   Mechanical Service Technicians led by: **Fred Kobasiuk**

-   Survey Group led by: **Frank Karl**

-   Beam Service Technicians led by**: Paul Valli**

-   Electronic Service Technicians led by: **Bill Anderson**

-   AGS Instrumentation Group led by: **Pete Stillman**

-   AGS Main Control Room and Operations led by: **Pete Ingrassia**

-   Health Physics Group led by: **Chuck Schaefer**

-   AGS Electricians led by **Bill Softye**

-   AGS Riggers led by: **Nick Cipolla**

-   Carpenter and Welder Support Service and Technical Support led by:
    **Roger Hubbard**

**[Medical Department:]{.underline}**

-   Dept. Chair: **John Gatley**

-   Medical Liaison: **Marcelo E. Vazquez**

-   Building manager: **W. Gunther**

-   Administration: **Denise White and Donna Russo**

-   Animal Care Facilities: **Maryann Kershaw, Kerry Bonti, Chris
    Risland.**

-   Technical support**: Opal Thomas, Katherine Conkling, Bae Pyatt**

-   Training Coordinator: **Ann Emrick**

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```
-   **[RCD]{.underline}**

-   **Kay Conkling**

-   **Dennis Ryan**

-   **Deana Buckallew**

-   **Jim Williams**

-   **Bob Colichio**

**[Plant Engineering:]{.underline}**

-   BLAF Custodian, **P. Abrams**

-   Plumbers: **B. McCafferty**

-   Painters/Carpenters: **B. Laakmann**

-   Electricians: **T. Baldwin**

[**Biology Department**:]{.underline}

-   Chairman: **Carl Anderson**

-   **Betsy Sutherland**

-   Cesiun Source Manager: **Richard Satkulis**

    **[Lawrence Berkeley National Laboratory:]{.underline}**

-   **Jack Miller**

-   **Lawrence Heilbronn**

-   **M. Nyman**

-   **R. P. Singh**

-   **W. Holley**

**BNL-9 PICTORIAL**

![](media/image18.jpeg){width="3.0in" height="2.25in"}

![](media/image20.jpeg){width="3.0in" height="2.247916666666667in"}

![](media/image22.jpeg){width="3.0in" height="2.247916666666667in"}

![](media/image24.jpeg){width="3.0in" height="2.2444444444444445in"}

![](media/image26.jpeg){width="3.0in" height="2.247916666666667in"}

![](media/image28.jpeg){width="3.0in" height="2.247916666666667in"}

![](media/image22.jpeg){width="3.00625in" height="2.252083333333333in"}

![](media/image30.jpeg){width="2.75in" height="2.0597222222222222in"}

![](media/image32.jpeg){width="3.00625in" height="2.2527777777777778in"}

![](media/image34.jpeg){width="2.529861111111111in" height="3.375in"}