**April, 2006**

[CURRICULUM VITAE]{.underline}

[Name]{.underline}: Sichuan Xi

[Citizenship]{.underline}: China (permanent resident of United States)

[Education]{.underline}:

1990 M.D., Medicine, The Bin Zhou Medical College, Binzhou, China

1993 M.Phil., Respiratory Pathology, The Tong Ji Medical University,
Wuhan, China

2001 Ph.D., Molecular Signalling Pathway in Cancer, University of Hong
Kong, Hong Kong, China

[Brief Chronology of Employment]{.underline}:

1988-1990 Intern, Department of Internal Medicine, Affilated Hospital of
Bin Zhou Medical College, Binzhou, China

1990-1993 China Scientific Foundation Scholar, Department of Pathology,
Tong Ji Medical University, Wuhan, China

1993-1997 Clinical Pathologist and Assistant Professor, Department of
Pathology, Peking Union Medical College, Beijing, China

2001-2005 Research Associate, Department of Otolaryngology, University
of Pittsburgh, Pittsburg, PA

2005-present Visiting Fellow, Laboratory of Cancer Prevention,
NCI-Frederick, Frederick, MD

[Volunteering]{.underline}:

1995-1997 Academic Secretary, Pathology Department, FuWai Hospital,
Chinese Academy of Medical Sciences, Beijing, China

1985-1990 Chairman, Student Union and Handicapped Students Union, Bin
Zhou Medical College, Binzhou, China

1998-2000 Postgraduate Representative, Medical Faculty, University of
Hong Kong, Hong Kong, China

1999-2000 Chairman, Overseas Students Union, University of Hong Kong,
Hong Kong, China

[Societies]{.underline}:

> Member, American History Channel Club
>
> Associate membership of American Association of Cancer Research
>
> Registered medical practitioner of the Medical Council of P.R. China.
>
> Registered Pathologist of the Medical Council of P.R. China.

Life Member of the Chinese Medical Association.

> Member of the Chinese Association for Physiological Sciences.

[Honor and Other Special Scientific Recognition]{.underline}:

1987 Certificate of Merit and Prize was awarded to Xi Sichuan for
outstanding performance in medical studies by National Education
Committee, National Health Ministry, and National Public Ministry of
P.R. China for outstanding performance in medical studies

1988 Certificate of Merit and Prize was awarded to Xi Sichuan for
outstanding performance in medical studies by Chinese Union for the
Handicapped of P.R. China

1989 Certificate of Merit and Prize was awarded to Xi Sichuan for
outstanding performance in medical studies by BinZhou Medical College

1990 Reporter from BINZHOU YIXUEYUAN BAO, a news express of BinZhou
medical college, wrote a news report for outstanding academic progress
and performance of Xi Sichuan in the first edition, Issue 45, June 25

1990 Reporter from DAZHONG Daily, a famous Chinese mainstream newspaper,
wrote a news report for outstanding academic progress and performance of
Xi Sichuan in the first edition, Issue 17213, June, 30

1995 Honorary invitation of Xi Sichuan to attend Fourth Congress of Asia
Pacific Association of Societies of Pathologists held in Beijing, China

1996 Certificate of Merit was awarded to Xi Sichuan on March 15, 1995 by
Chinese Academy of Medical Sciences, Chinese Hypertension Union, and
ChenTao Pulmonary Hypertension Funds for his outstanding dissertation
entitled "The inhibitory effects of Radix Astragali on hypoxic pulmonary
hypertension of rats" published in *Chinese Journal of Pathology* 25(4):
236-238

1998 Certificate of Merit was awarded to Xi Sichuan in the Department of
Physiology for outstanding performance in the category of Endocrinology
and Reproduction at the Postgraduate Symposium, December 16

2000 Postgraduate Studentship was awarded to Xi Sichuan in the
Department of Physiology for outstanding performance in his Ph.D. thesis
preparation, July 1 to September 30

2000 Awarded as excellent visiting scholar by Chinese government on
December 12

[Participation in Research Programs and NIH Grants]{.underline}:

2001-Present NIH Grant 2: Stat3 as a Therapeutic Target in Head and Neck
Cancer (RO1 CA 7730804).

2001-Present NIH Grant 1: STAT-Mediated TGF-α/EGFR Signaling in SCCHN
(R01 CA

77308).

2004-Present SPORE program in Head and Neck Cancer (Molecular Mechanism
of Stats in

Head and Neck Squamous Cell Cancer).

[Publications]{.underline}

1\. Xi, S.: Review: Control of the growth of fibroblast. *The Chinese J.
Burns Wounds & Surface Ulcers* 1: 5-7, 1994 (in Chinese).

2\. Xi., S.: Review: Endothelial- derived growth factors and structural
remodeling of pulmonary arteries. *J. BINZHOU Med. Coll.* 17 (1): 79-82,
1994 (in Chinese).

3\. Xi, S., Che, D-Y. and Zhang, W-R.: The inhibitory effect of radix
salviae miltiorrhizae on hypoxic structural remodeling of intraacinar
pulmonary arteries. *Acta. Univ. Med. Tongji*. 23 (2): 81-83, 1994 (in
Chinese).

4\. Xi, S., Che, D-Y. and Zhang, W-R.: The inhibitory effect of radix
salviae miltiorrhizae on hypoxic structural remodeling of intraacinar
pulmonary arteries. *J. Tongji Med. Univ.* 14 (3): 148-152, 1994.

5\. Xi, S.: Review: The molecular biology of elastin and collagen in the
dermis. *The Chinese J. Burns Wounds & Surface Ulcers* 2: 11-12, 1995
(in Chinese).

6\. Xi, S., Che, D-Y. and Zhang, W-R.: Hypoxic pulmonary hypertension
and structural remodeling of intraacinar pulmonary arteries. *Chinese J.
Circulation* 10 (5): 287-290, 1995 (in Chinese).

7\. Xi, S. and Xu, H.: Review: Endothelial- derived growth factors and
structural remodeling of pulmonary arteries. *Medical J. Shenzhen* 9
(3): 81-83, 1996 (in Chinese).

8\. Xu, H. and Xi, S.: Review: The biological property and role of
endogenous nitric oxide. *The Chinese J. Burns Wounds & Surface Ulcers*
3: 5-7, 1996 (in Chinese).

9\. Xi, S., Ruan, Y-M., Zhang, L-Z. and Si, W-X.: The inhibitory effects
of radix astragali on hypoxic pulmonary hypertension of rats. *Chinese
J. Pathol.* 25(4): 236-238, 1996 (in Chinese).

10\. Xi, S., Ruan, Y-M., Zhang, L-Z., Hang, L-Z., Si, W-X. and Li, H-T.:
Experimental studies on inhibitory effects of radix peucedani on hypoxic
pulmonary hypertension in rats. *Chinese J. Sino-Western Med. Studies*
16 (4): 218-220, 1996 (in Chinese).

11\. Xi S. and Xu, H.: Review: Cytokines and asthma. *Med. Clinic and
Study* 6(3): 27-28, 1997 (in Chinese).

12\. Chen, X., Ruan, Y., Xi, S., Si, W. and Zhang, L.: Therapeutic
effect of radix Astragali on hypoxia pulmonary hypertension in rats.
*Zhongguo Zhong Yao Za Zhi* 22 (7): 432-434, 1997.

13\. Xi, S., Wang, H-Y., Wang, Q-Z. and Liu, Y-H.: Primary malignant
cardiac neoplasms: a study of 16 biopsy cases. *J. Clinical Oncol.* 2
(4): 1-4, 1997 (in Chinese).

14\. Xi, S., Xu, H. and Chen, D.: A specific electron stain for elastic
fibers in pulmonary vessels. *J. BINZHOU Med. Coll.* 20 (6): 610-611,
1997 (in Chinese).

15\. Xi, S., Ruan, Y-M., Zhang, L-Z., Si, W-X. and Li, H-T.: The
preventive effects of radix peucedani on hypoxic pulmonary hypertension
in rats. *Sino-Western Med. Studies* 8 (1): 85-88, 1997 (in Japanese).

16\. Xi, S., Liu, Y-H., Ruan, Y-M. and Si, W-X.: Case report:
pathological changes of takayasu arteritis in the autopsy. *J. Clin.
Exp. Pathol.* 14 (2): 122, 1998 (in Chinese).

17\. Xi, S., Wang, H-Y., Ruan, Y-M. and Han, X-N.: Case report:
pathological changes of complex malformation of heart in the autopsy.
*Chinese J. Clinical Anatomy* 16 (1): 4, 1998 (in Chinese).

18\. Pang, C.S., Xi, S., Yau, M.Y.C., Wang, X.F., Yang, J.C.S., Tang,
P.L. and Pang, S.F.: Melatonin receptors in the chick heart: modulation
on isoproterenol stimulated cAMP level. *Biol. Signals Recept.* 7: 268,
1998.

19\. Xi. S., Wang, H-Y., Wang, Q-Z. and Liu, Y-H.: Clinical analysis of
primary malignant cardiac neoplasms. *J. Clin. Med.* 2 (4): 1-4, 1998
(in Chinese).

20\. Xi, S., Ruan, Y-M., Liu, Y-H. and Zhang, L-Z.: Morphometric
investigation on hypoxic structural remodeling of intraacinar pulmonary
arteries. *Chinese J. Tuberculosis and Respiratory Diseases* 21 (5):
303-305, 1998 (in Chinese).

21\. Xi, S., Ruan, Y., Liu, Y., Zhang, L. and Si, W.: The inhibitory
effects of radix astragali on hypoxic pulmonary hypertension of rats.
*Chinese Med. J.* 111 (10): 956-958, 1998.

22\. Xi, S., Li, L. and Shiu, S.Y.W.: Changes in proliferation and
apoptosis of human choriocarcinoma JAr and prostate cancer LNCaP cells
induced by polysaccharide peptide (PSP) of Yun Zhi. *Biol. Signals
Recept.* 8: 215, 1999.

23\. Siu, S.W.F., Fong, S.W., Xi, S.C., Wong, J.T.Y. and Shiu, S.Y.W.:
Inhibition of hormone-growth factor-induced rise in cytosolic free
calcium (\[Ca^2+^\]~i~) in human prostate cancer and choriocarcinoma
cells by melatonin. *Biol. Signals Recept.* 9 (1): 68, 2000.

24\. Pang, C.S., Yang, J.C.S., Xi, S.C., Tang, P.L., Brown, G.M. and
Pang, S.F.: Melatonin receptors in the chick heart, characterization,
ontogeny and developmental studies. *Biol. Signals Recept.* 9 (1): 64,
2000.

25\. Shiu, S.Y.W., Li, L., Siu, S.W.F., Xi, S.C., Fong, S.W. and Pang,
S.F.: Biological basis and possible physiological implications of
melatonin receptor-mediated signaling in the rat epididymis. *Biol.
Signals Recept.* 9 (3-4): 172-187, 2000.

26\. Shiu, S.Y.W., Xi, S.C., Xu, J.N., Mei, L., Pang, S.F., Yao, K.M.
and Wong, J.T.Y.: Inhibition of malignant trophoblastic cell
proliferation in vitro and in vivo by melatonin. *Life Sci.* 67:
2059-2074, 2000.

27\. Xi, S.C., Tam, P.C., Brown, G.M., Pang, S.F. and Shiu, S.Y.W.:
Potential involvement of mt1 receptor and attenuated sex steroid-induced
calcium influx in the direct anti-proliferative action of melatonin on
androgen-responsive LNCaP human prostate cancer cells. *J. Pineal. Res*.
29: 172-183, 2000.

28\. Ryter, S.W., Xi, S., Hartsfield, C.L. and Choi, A.M.: Mitogen
activated protein kinase (MAPK) pathway regulates heme oxygenase-1 gene
expression by hypoxia in vascular cells. *Antioxid Redox Signal* 4:
587-592, 2002.

29\. Kijima, T., Niwa, H., Steinman, R.A., Drenning, S.D., Gooding,
W.E., Wentzel, A.L., Xi, S. and Grandis, J.R.: Stat3 activation
abrogates growth factor dependence and contributes to head and neck
squamous cell carcinoma tumor growth in vivo. *Cell Growth Differ.* 13:
355-362, 2002*.*

30\. Pang, C.S., Xi, S.C., Brown, G.M., Pang S.F. and Shiu, S.Y.:
2\[125I\] Iodomelatonin binding and interaction with beta-adrenergic
signaling in chick heart/coronary artery physiology. *J. Pineal. Res.*
32:243-252, 2002.

31\. Lango, M., Wentzel, A.L., Song, J.I., Xi, S., Johnson, D.E., Dyer,
K.F., Lamph, W.W., Miller, L. and Grandis, J.R.: Responsiveness to the
RAR-selective retinoid (LGD1550) correlates with abrogation of
TGF-α/EGFR autocrine signaling in head and neck squamous carcinoma
cells. *Clin. Cancer Res.* 9: 4205-4213, 2003.

32\. Leong, P.L., Xi, S., Drenning, S.D., Dyer. K.F., Wentzel, A.L.,
Lerner, E.C., Smithgall, T.E. and Grandis, J.R.: Differential function
of Stat5 isoforms in head and neck cancer control. *Oncogene* 21:
2846-2853, 2002.

33\. Leong, P.L., Andrews, G.A., Johnson, D.E., Dyer, K.F., Xi, S., Mai,
J.C., Robbins, P.D., Gadiparthi, S., Burke, N.A., Watkins, S.F. and
Grandis, J.R.: Targeted inhibition of Stat3 with a decoy oligonucleotide
abrogates Stat3-mediated DNA binding, gene expression and head and neck
cancer cell growth. *Proc. Natl. Acad. Sci. U.S.A.* 100: 4138-4143,
2003.

34\. Xi, S. and Grandis, J.R.: Gene therapy for the treatment of oral
squamous cell carcinoma. *J. Dent. Res.* 82: 11-16, 2003.

35\. Xi, S., Zhang, Q., Gooding, W.E., Smithgall, T.E.and Grandis, J.R.:
Constitutive activation of STAT5b contributes to carcinogenesis in vivo.
*Cancer Res*. 63: October 15, 6763-6771, 2003.

36\. Xi, S., Zhang ,Q., Dyer, K.F., Lerner, E.C., Smithgall, T.E.,
Gooding, W.E., Kamens, J, and Grandis, J.R.: Src kinases mediate STAT
growth pathways in squamous cell carcinoma of the head and neck. *J.
Biol. Chem.* 278: 31574-31583, 2003.

37\. Zhang, Q., Thomas, S.M., Xi, S., Siegfried, J.M. and Grandis, J.R.:
Src family kinases mediate epidermal growth factor receptor ligand
cleavage, proliferation, and invasion of head and neck cancer cells.
*Cancer Res.* 64: 6166-6173, 2004.

38\. Andrews, G.A., Xi, S., Pomerantz, R., Lin, C., Gooding, W.E.,
Wentzel ,A.L., Sidransky, D. and Grandis, J.R.: Mutation of p53 in head
and neck squamous cell carcinoma correlates with Bcl-2 expression and
increased susceptibility to cisplatin-induced apoptosis. *Head and Neck*
26: 870-877, 2004.

39\. Lai, S.Y., Childs, E.E., Xi, S., Coppelli, F.M., Gooding, W.E.,
Wells, A., Ferris, R.L. and Grandis, J.R.: Erythropoietin-mediated
activation of JAK-STAT signaling contributes to cellular invasion in
head and neck squamous cell carcinoma. *Oncogene* 24:4442-4449, 2005.

40\. Xi, S., Gooding, W.E. and Grandis, J.R.: Antitumor efficacy of
STAT3 blockade using a transcription factor decoy approach: implications
for cancer therapy. Oncogene 24: 970-979, 2005.

41\. Heming, Z., Geiman, T.M., Xi, S., Schmidtmann, A., Jiang, Q., Chen,
T., Li, E., and Muegge, K. Lsh is involved in de novo methylation of
DNA. *[Embo J.]{.underline}* 2006 Jan 5; \[Epub ahead of print\].

[Manuscripts Submitted]{.underline}:

1.  Xi, S., Dyer, K.F., Kimark, M., Gooding, W.E., Chaillet, J.R.,
    Ferrell, R.E. and Grandis, J.R.: Inactivation of STAT1 by promoter
    methylation is critical for squamous cell carcinogenesis. Submitted
    to *PNAS*, 2005.

2.  Zhang, Q., Xi, S., Thomas, S.M., Siegfried, J.M., Fan, H.,
    Smithgall, T.E. and Grandis, J.R.: Src and PI3 kinase mediated TACE
    phosphorylation contributes to GRP-induced EGFR activation in SCCHN.
    Submitted to *Cancer Cell*, 2005.

3.  He, C.H., Xi, S. and Alam, J.: Identification of novel interation
    between transcription factor Nrf2 and vacuo;ar H-ATPase subunit D,
    an ATPase/ATP synthase, by yeast two-hybrid system: implication in
    heme oxygenase-1 (HO-1) gene regulation. Submitted to *J. Biol.
    Chem*., 2005.

[Manuscripts in Press]{.underline}:

1.  Xi, S., Wang, Q. and Yuhe, L.: Clinical study on right atrial
    metastasis of hepatic cell carcinoma. Submitted to *Chinese J.
    Pathol.*, 2005 (in Chinese).

[Conferences/Workshops]{.underline}:

1\. Xi, S.C., Pang, S.F. and Shiu, S.Y.W.: Calcium influx in the direct
anti-proliferative action of melatonin on androgen-responsive LNCaP
human prostate cancer cells. *Experimental Biology 2000, San Diego, CA,
April 15-18, 2000.*

2\. Xi, S.C., Pang, S.F., Tam, P.C. and Shiu, S.Y.W.: Expression of
melatonin receptors in human prostate cancer. *2000 Annual Meeting of
International Melatonin Research, May, 2000, Hong Kong, China.*

3\. Xi, S.C., Pang, S.F. and Shiu, S.Y.W.: Attenuated sex
steroid-induced calcium influx in the direct anti-proliferative action
of melatonin on androgen-responsive LNCaP human prostate cancer cells.
*91^st^ Annual Meeting of American Association for Cancer Research,
April 1-5, 2000, San Francisco, CA (Proceeding of the American
Association for Cancer Research)*.

4\. Xi, S., Dyer, K.F., Zhang, Q., Lerner, E.C., Smithgall, T.E. and
Grandis, J.R.: Involvement of STAT5 in head and neck cancer
carcinogenesis. *Sixth Research Workshop on the Biology, Prevention, and
Treatment of Head and Neck Cancer, October 9-13, 2002, McLean, VA*.

5\. Xi, S., Leong, P.L., Drenning, S.D., Dyer, K.F., Wentzel, A.L.,
Lerner, E.C., Smithgall, T.E. and Grandis, J.R.: Differential function
of Stat5 isoforms in head and neck cancer control. *93^rd^ Annual
Meeting of American Association for Cancer Research, April 6-10, 2002,
San Francisco, CA (Proceeding of the American Association for Cancer
Research)*.

6\. Lai, S.Y., Xi, S., Childs, E.E. and Grandis, J.R.: Erythropoietin
stimulates proliferation and invasion in head and neck squamous cell
carcinoma. *Keystone Meeting 2004*.

7\. Zhang, Q., Thomas, S.M., Xi, S., Siegfried, J.M. and Grandis, J.R.:
Src family kinases mediated-epidermal growth factor receptor (EGFR)
activation by gastrin-releasing peptide (GRP) in head and nneck squamous
cell carcinoma (HNSCC). *95^rd^ Annual Meeting of American Association
for Cancer Research, March 27-31, 2004, Orlando, FL, (Proceeding of the
American Association for Cancer Research)*.

8\. Lai, S.Y., Xi, S., Childs, E.E. and Grandis, J.R.: Erythropoietin
stimulates proliferation and invasion in head and neck squamous cell
carcinoma. Oral presentation. *6th International Conference on Head and
Neck Cancer, 2004*.

9\. Xi, S., Gooding, W.E. and Grandis, J.R.: Antitumor efficacy of STAT3
blockade using a transcription factor decoy approach: implications for
cancer therapy. *95^rd^ Annual Meeting of American Association for
Cancer Research, March 27-31, 2004, Orlando, FL (Proceeding of the
American Association for Cancer Research)*.

10 Zhang, Q., Xi, S., Thomas, S.M., Siegfried, J.M., Fan, H., Smithgall,
T.E. and Grandis, J.R.: Src and PI3 kinase mediated TACE phosphorylation
contributes to GRP-induced EGFR activation in SCCHN. *96^rd^ Annual
Meeting of American Association for Cancer Research, April 16-20, 2005,
Anaheim, CA (Proceeding of the American Association for Cancer
Research)*.

11\. S., Xi , Dyer, K.F., Kimark, M., Gooding, W.E., Chaillet, J.R.,
Ferrell, R.E. and Grandis, J.R.: Inactivation of STAT1 contributes to
head and neck carcinogenesis. *96^rd^ Annual Meeting of American
Association for Cancer Research, April 16-20, 2005, Anaheim, CA
(Proceeding of the American Association for Cancer Research)*. Oral
presentation in minisymposium of carcinogenesis section 19, AACR.