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**UNITED STATES ENVIRONMENTAL PROTECTION AGENCY**

**WASHINGTON D.C., 20460**

**OFFICE OF**

**PREVENTION, PESTICIDES AND**

**TOXIC SUBSTANCES**

October 25, 2005

PC Code: 109702

DP Barcode: D293410

**MEMORANDUM**

*Subject:* Revised EFED Risk Assessment for the Reregistration
Eligibility Decision (RED) on Cypermethrin After 30-Day "Error Only"
Comment Period

*To:* Veronique LaCapre, Chemical Review Manager

Yan Donovan, Chemical Review Manager

> Margaret Rice, Branch Chief
>
> Reregistration Branch II

Special Review and Reregistration Division (7505C)

*From:* Miachel Rexrode, Ph.D., Fishery Biologist

José Luis Meléndez, Chemist

> Environmental Risk Branch V
>
> Environmental Fate and Effects Division (7507C)

*Through:* Mah Shamim, Ph.D., Chief

> Environmental Risk Branch V
>
> Environmental Fate and Effects Division (7507C)

The registrants of cypermethrin, Valent BioSciences Corporation, FMC
Corporation and Syngenta Crop Protection provided error correction
comments on the Draft of the EFED Chapter of the Reregistration
Elegibility Document (RED) for Cypermethrin. The purpose of this
memorandum is to address those comments. The revised science chapter and
appendices are issued under DP Barcode D293412.

In general, the EFED addressed the errors only comments. Those from FMC
Corporation and Syngenta Crop Protection, were addressed first, using
the original comments that they provided in a table format, with the
responses added. Valent BioSciences Corporation provided a one-page
table with comments (image provided in this review). Those comments are
addressed at the end of this document.

**FMC Corporation and Syngenta Crop Protection Error Correction**

**Comments and Responses:**

Note: Typographical errors were noted in a separate pdf file. They are
not listed in this review.

+---------------+------------------+-----------------------------------+
| **Header**    | **pdf Version    | **Comments**                      |
|               | Page #;          |                                   |
|               | Paragraph \#**   |                                   |
+---------------+------------------+-----------------------------------+
| U             | Page iii, 4      | The paragraph describes model     |
| ncertainties: |                  | uncertainty. Please reword the    |
| Environmental |                  | second sentence for clarity. "The |
| Fate          |                  | results of a simplistic analysis  |
|               |                  | of spray drift and buffer         |
|               |                  | zones...indicated that the        |
|               |                  | concentrations resulting from     |
|               |                  | actual applications of            |
|               |                  | cypermethrin could be higher or   |
|               |                  | lower depending upon actual       |
|               |                  | application practices."           |
|               |                  |                                   |
|               |                  | **RESPONSE: THE SENTENCE WAS      |
|               |                  | MODIFIED SLIGHTLY FOR CLARITY,    |
|               |                  | BUT NOT ACCORDING TO THE          |
|               |                  | REGISTRANT'S RECOMMENDATION.**    |
+---------------+------------------+-----------------------------------+
| Table of      | General comments | 1\) Supplementary tables are not  |
| Contents      |                  | listed in the Table of Contents.  |
|               |                  |                                   |
|               |                  | 2\) Most of the Figures are not   |
|               |                  | listed in the table of contents.  |
|               |                  |                                   |
|               |                  | 3\) The table of contents needs   |
|               |                  | to be updated to reflect actual   |
|               |                  | page numbers in the document.     |
|               |                  |                                   |
|               |                  | **RESPONSE: THESE WERE            |
|               |                  | CORRECTED.**                      |
+---------------+------------------+-----------------------------------+
| Table I-1,    | Page vi,         | MRID 42129002                     |
| Cypermethrin  | leaching-adsor   |                                   |
| Table of      | ption/desorption | **RESPONSE: AGREE, CORRECTED.**   |
| Environmental |                  |                                   |
| Fate Data     |                  |                                   |
| Requirements  |                  |                                   |
+---------------+------------------+-----------------------------------+
|               | Page vi, aquatic | MRID 44876107- needs to be added  |
|               | field            | to references.                    |
|               | dissipation      |                                   |
|               |                  | **RESPONSE: AGREE, ADDED.**       |
+---------------+------------------+-----------------------------------+
| Table I-2,    | Page x.          | 72-4, MRID 89047 is a 21-day      |
| Ecological    |                  | daphnia magna not a marine study  |
| Effects Data  |                  | but freshwater study              |
| Requirements  |                  |                                   |
| for           |                  | **RESPONSE: AGREED, THIS HAS BEEN |
| Cypermethrin  |                  | CHANGED**                         |
+---------------+------------------+-----------------------------------+
|               | Page x, aquatic  | MRID 45121822- needs to be        |
|               | invertebrate     | referenced                        |
|               | life-cycle       |                                   |
|               | (freshwater)     | **RESPONSE: CORRECTED**           |
+---------------+------------------+-----------------------------------+
|               | Page xi          | MRID 40274001- residues on        |
|               |                  | foliage honeybee toxicity test    |
|               |                  | needs to be referenced            |
|               |                  |                                   |
|               |                  | **RESPONSE: CORRECTED**           |
+---------------+------------------+-----------------------------------+
| Table of      | Page xiii        | 'd.' should be bioaccumulation    |
| Contents      |                  | and 'e' should be Field Studies.  |
|               |                  |                                   |
| iii, B. 1. d  |                  | **RESPONSE: AGREE, CORRECTED.**   |
+---------------+------------------+-----------------------------------+
| Table of      | Page xiv         | 'c.' should be 'use of buffer     |
| Contents IV,  |                  | zones' and 'd.' should be aquatic |
| A. 1. C.      |                  | plants                            |
|               |                  |                                   |
|               |                  | **RESPONSE: AGREE, CORRECTED.**   |
+---------------+------------------+-----------------------------------+
| Table of      | Page xv          | Co-occurrence Analysis - These    |
| Contents IV,  |                  | sections do not appear to be in   |
| B., 5., e.    |                  | the text: (2) Probit dose         |
|               |                  | Response Relationship, (3). Data  |
|               |                  | Related to Under-represented Taxa |
|               |                  | and (4). Implications of          |
|               |                  | Sublethal Effects and c Indirect  |
|               |                  | Effects Analysis.                 |
|               |                  |                                   |
|               |                  | **RESPONSE: AGREE, THEY WERE      |
|               |                  | DELETED FROM THE TABLE OF         |
|               |                  | CONTENTS.**                       |
+---------------+------------------+-----------------------------------+

+--------------+-----------------+---+------------------------------------+
| **Header**   | **pdf Version   | * |                                    |
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+--------------+-----------------+---+------------------------------------+
| Risk to      | Page 2,         | 1 |                                    |
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+--------------+-----------------+---+------------------------------------+
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| C.           | Page 3,         | P |                                    |
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+--------------+-----------------+---+------------------------------------+
| **Header**   | **pdf Version   |   | **Comments**                       |
|              | Page #;         |   |                                    |
|              | Paragraph \#**  |   |                                    |
+--------------+-----------------+---+------------------------------------+
| C.           | Page 4; 5       |   | According the cypermethrin label,  |
| Conclusions- |                 |   | the risk assessment should only be |
| Exposure     |                 |   | conducted with the following       |
| Chara        |                 |   | buffers:                           |
| cterizations |                 |   |                                    |
|              |                 |   | The label of cypermethrin requires |
|              |                 |   | the following buffer zones: 25 ft  |
|              |                 |   | for ground applications; 150 ft    |
|              |                 |   | for aerial applications; and 450   |
|              |                 |   | ft for ultra low volume (ULV)      |
|              |                 |   | aircraft application. A vegetative |
|              |                 |   | filter strip is also required (10  |
|              |                 |   | ft) to protect any aquatic area    |
|              |                 |   | from runoff.                       |
|              |                 |   |                                    |
|              |                 |   | **RESPONSE: THE SENTENCE WAS       |
|              |                 |   | MODIFIED TO INDICATE THAT A 150 ft |
|              |                 |   | BUFFER ZONE IS IMPOSED (AS OPPOSED |
|              |                 |   | TO "PROPOSED"), FOR AERIAL         |
|              |                 |   | APPLICATIONS.**                    |
+--------------+-----------------+---+------------------------------------+
| D.           | Page 5.         |   | Last sentence in 1^st^ paragraph   |
| Conclusions  |                 |   | in section, does not seem to       |
|              |                 |   | belong, delete entire sentence.    |
|              |                 |   | **RESPONSE: CORRECTED**            |
+--------------+-----------------+---+------------------------------------+
|              |                 |   | Last sentence on page, add "LOAEC" |
|              |                 |   | before 0.33 ug ai/L. **RESPONSE:   |
|              |                 |   | CORRECTED**                        |
+--------------+-----------------+---+------------------------------------+
|              | Page 6          |   | 1^st^ string of words on page;     |
|              |                 |   | complete the sentence by           |
|              |                 |   | including - ... produced NOAEC at  |
|              |                 |   | 0.78ng ai/L based on 1^st^         |
|              |                 |   | generation mortality, a NOEC of    |
|              |                 |   | 1.5 ng ai/L was observed based on  |
|              |                 |   | survival and reproduction.         |
|              |                 |   |                                    |
|              |                 |   | **RESPONSE: CORRECTED**            |
+--------------+-----------------+---+------------------------------------+
|              | Page 6, 2^nd^   |   | States avian repro studies were    |
|              | full paragraph  |   | incomplete because LOAEC was not   |
|              |                 |   | determined however on page E-61    |
|              |                 |   | both studies are classified as     |
|              |                 |   | Acceptable and in the 4^th^ line   |
|              |                 |   | above the table it is stated that  |
|              |                 |   | "The guideline (71-4) is           |
|              |                 |   | fulfilled."                        |
|              |                 |   |                                    |
|              |                 |   | **RESPONSE: CORRECTED AND CHANGED  |
|              |                 |   | TO SUMMENTAL. AVIAN REPORDUCTION   |
|              |                 |   | STUDY MUST BE REPEATED IN ORDER TO |
|              |                 |   | ESTABLISH LOAEC.**                 |
+--------------+-----------------+---+------------------------------------+
| Problem      | Page 7.         |   | Source and Intensity. This         |
| Formulation  |                 |   | assessment only addressed the      |
|              | Section II. A.  |   | risks from agricultural uses of    |
|              | 1               |   | cypermethrin.                      |
|              |                 |   |                                    |
|              |                 |   | **RESPONSE: THIS COMMENT IS NOT AN |
|              |                 |   | ERROR; THE FIRST SENTENCE OF       |
|              |                 |   | SECTION I-B ALREADY STATES THAT    |
|              |                 |   | THE FOCUS OF THE ASSESSMENT IS ON  |
|              |                 |   | AGRICULTURAL APPLICATIONS.**       |
+--------------+-----------------+---+------------------------------------+
|              | Page 8          |   | 1^st^ sentence in section, RED     |
|              |                 |   | should cite Koc of 310000 (based   |
|              |                 |   | on extensive work from PWG)        |
|              |                 |   |                                    |
|              |                 |   | **RESPONSE: THIS ISSUE WAS         |
|              |                 |   | ADDRESSED PREVIOUSLY, PLEASE SEE   |
|              |                 |   | ABOVE (pp. 3-4).**                 |
+--------------+-----------------+---+------------------------------------+
|              | Page 8. Section |   | EFED refer to a K~oc~ value of     |
|              | II.A.2          |   | 20,800. As EFED are aware, there   |
|              | ("Physica       |   | is a published peer reviewed       |
|              | l/Chemical/fate |   | review of pyrethroid fate          |
|              | and transport   |   | properties, including those of     |
|              | properties").   |   | cypermethrin (Laskowski, MRID      |
|              |                 |   | 45169501) containing all the       |
|              |                 |   | quality ranked data on soil        |
|              |                 |   | sorption. The Laskowski            |
|              |                 |   | publication provides a thorough    |
|              |                 |   | assessment of soil sorption        |
|              |                 |   | properties and proposes that best  |
|              |                 |   | estimate for the Koc of            |
|              |                 |   | cypermethrin is 310,000,           |
|              |                 |   | indicating that the value referred |
|              |                 |   | to by EFED is an underestimate.    |
|              |                 |   |                                    |
|              |                 |   | **RESPONSE: THIS ISSUE WAS         |
|              |                 |   | ADDRESSED PREVIOUSLY, PLEASE SEE   |
|              |                 |   | ABOVE (pp. 3-4).**                 |
+--------------+-----------------+---+------------------------------------+
| **Header**   | **pdf Version   |   | **Comments**                       |
|              | Page #;         |   |                                    |
|              | Paragraph \#**  |   |                                    |
+--------------+-----------------+---+------------------------------------+
| Problem      | Page 9, Table 1 |   | Log Kow should be 6.54 not 6.4     |
| Formulation  |                 |   |                                    |
|              |                 |   | **RESPONSE: AGREE, CORRECTED.**    |
+--------------+-----------------+---+------------------------------------+
|              | Page 12.        |   | Reiterates ecological effects and  |
|              |                 |   | tries to justify assessment        |
|              | Section II.B.3  |   | endpoints, but doesn't say         |
|              | ("Ecosystems at |   | anything about which ecosystems    |
|              | Risk")          |   | are potentially at risk, nor about |
|              |                 |   | the protection goals for those     |
|              |                 |   | ecosystems. In the first paragraph |
|              |                 |   | it is stated "in order to protect  |
|              |                 |   | threatened and endangered species, |
|              |                 |   | all assessment endpoints are       |
|              |                 |   | measured at the individual level   |
|              |                 |   | and provide insight about risks at |
|              |                 |   | higher levels of biological        |
|              |                 |   | organization (e.g., populations    |
|              |                 |   | and communities)." Does this       |
|              |                 |   | sentence apply only to T&E         |
|              |                 |   | species---i.e., protection is      |
|              |                 |   | applied at the individual level?   |
|              |                 |   |                                    |
|              |                 |   | **RESPONSE: CORRECTED. This        |
|              |                 |   | applies to engangered and          |
|              |                 |   | threatened species.\`**            |
|              |                 |   |                                    |
|              |                 |   | Or is this intended to link the    |
|              |                 |   | individual-based measures of       |
|              |                 |   | effect to the population and       |
|              |                 |   | community-based assessment         |
|              |                 |   | endpoints for non-T&E species as   |
|              |                 |   | well? The statement, "pesticide    |
|              |                 |   | effects on individual survivorship |
|              |                 |   | have important implications for    |
|              |                 |   | ... habitat carrying capacity" is  |
|              |                 |   | questionable; habitat carrying     |
|              |                 |   | capacity sets the limit to         |
|              |                 |   | population abundance, but how is   |
|              |                 |   | the habitat's carrying capacity    |
|              |                 |   | for a population influenced by     |
|              |                 |   | individual survivorship within     |
|              |                 |   | that population? **RESPONSE:       |
|              |                 |   | AGREED AND CHANGED.**              |
+--------------+-----------------+---+------------------------------------+
|              | 10              |   | 4\. Overview...                    |
|              |                 |   |                                    |
|              |                 |   | 2^nd^ paragraph (last in section), |
|              |                 |   | clarify the bifenthrin RED         |
|              |                 |   | reference and update reference     |
|              |                 |   | section.                           |
|              |                 |   |                                    |
|              |                 |   | **RESPONSE: THIS SENTENCE WAS      |
|              |                 |   | INACURATE AND WAS DELETED.**       |
+--------------+-----------------+---+------------------------------------+
| **Header**   | **pdf Version   |   | **Comments**                       |
|              | Page #;         |   |                                    |
|              | Paragraph \#**  |   |                                    |
+--------------+-----------------+---+------------------------------------+
|              | Page 13.        |   | The attributes listed in the left  |
|              |                 |   | column aren't clearly defined      |
|              | Section II.C    |   | assessment endpoints. For example, |
|              | ("Assessment    |   | item 1 is "abundance (i.e.,        |
|              | Endpoints" of   |   | survival, reproduction, and        |
|              | Table 3).       |   | growth) of individuals and         |
|              |                 |   | populations of birds." First, is   |
|              |                 |   | there a difference between         |
|              |                 |   | abundance of individuals and       |
|              |                 |   | abundance of populations? Second,  |
|              |                 |   | survival, reproduction, and growth |
|              |                 |   | are not [equivalent]{.underline}   |
|              |                 |   | to population abundance (the       |
|              |                 |   | "i.e." is inappropriate); rather   |
|              |                 |   | they are factors that may          |
|              |                 |   | influence population abundance,    |
|              |                 |   | and in this case are also used as  |
|              |                 |   | measures of effect. Why is         |
|              |                 |   | "abundance" shown as the           |
|              |                 |   | assessment endpoint for birds,     |
|              |                 |   | mammals, and earthworms, but only  |
|              |                 |   | "survival and reproduction" for    |
|              |                 |   | fish and invertebrates and         |
|              |                 |   | "survival of ... populations" for  |
|              |                 |   | beneficial insects? This is an     |
|              |                 |   | attempt to fulfill the Guidelines  |
|              |                 |   | by categorizing the potential      |
|              |                 |   | effects of concern, but it is      |
|              |                 |   | vague and inconsistent about       |
|              |                 |   | actual endpoints and doesn't say   |
|              |                 |   | anything specific about protection |
|              |                 |   | goals. ? **RESPONSE: AGREED AND    |
|              |                 |   | CHANGED.**                         |
+--------------+-----------------+---+------------------------------------+

+--------------+-------------------+-----------------------------------+
| **Header**   | **pdf Version     | **Comments**                      |
|              | Page #; Paragraph |                                   |
|              | \#**              |                                   |
+--------------+-------------------+-----------------------------------+
| E. Analysis  | Page 18           | 2^nd^ sentence, reference USEPA   |
| Plan         |                   | 1998 missing in Ref list and the  |
|              |                   | name of the document (Guidance    |
|              |                   | for Ecological Risk Assessment)   |
|              |                   | is missing from the text.         |
|              |                   |                                   |
|              |                   | **RESPONSE: CORRECTED.**          |
+--------------+-------------------+-----------------------------------+
| c\. Measures | Page 21           | Last sentence -- delete the word  |
| of           |                   | "small" birds. Since 3 sizes of   |
| ecosystem... |                   | birds are being represented, not  |
|              |                   | just the small ones.              |
|              |                   |                                   |
|              |                   | **RESPONSE: CORRECTED.**          |
+--------------+-------------------+-----------------------------------+
| Analysis     | Page 22           | As EFED are aware, the Pyrethroid |
| (Section     |                   | Working Group is progressing a    |
| III)         |                   | program of work agreed with EFED  |
|              |                   | including the development of      |
|              |                   | refined exposure estimates based  |
|              |                   | on the best available usage data, |
|              |                   | generation of additional acute    |
|              |                   | and chronic ecotoxicity data for  |
|              |                   | sediment dwellers and the         |
|              |                   | compilation of a comprehensive    |
|              |                   | ecotoxicity data review for the   |
|              |                   | synthetic pyrethroids. These new  |
|              |                   | data and assessments, which will  |
|              |                   | be available over the coming      |
|              |                   | months, will be relevant to the   |
|              |                   | environmental risk assessment for |
|              |                   | cypermethrin.                     |
|              |                   |                                   |
|              |                   | **RESPONSE: AGREED. AT THE TIME   |
|              |                   | THAT THE DOCUMENT WAS BEING       |
|              |                   | PRODUCED THIS DATA WAS NOT        |
|              |                   | AVAILABLE. HOWEVER, THE ACUTE     |
|              |                   | SEDIMENT STUDIES HAVE BEEN        |
|              |                   | COMPLETED AND ARE BEING REVIEWED  |
|              |                   | BY EPA .**                        |
+--------------+-------------------+-----------------------------------+
| Table 4      | Page 22           | Head Lettuce (interval not        |
|              |                   | specified rather than 7 days).    |
|              |                   |                                   |
|              |                   | **RESPONSE: AGREE.**              |
+--------------+-------------------+-----------------------------------+
|              |                   | The Leafy Brassica listing should |
|              |                   | be as follows: includes broccoli  |
|              |                   | Raab, collards, kale, mustard     |
|              |                   | greens, mustard spinach, and rape |
|              |                   | greens.                           |
|              |                   |                                   |
|              |                   | **RESPONSE: IN ADDITION, CHINESE  |
|              |                   | CABAGGE.**                        |
+--------------+-------------------+-----------------------------------+
| Figures L-2  | Pages 25-30       | Figures are not legible.          |
| -- L-5       |                   |                                   |
|              |                   | **RESPONSE: THE FIGURES ARE CLEAR |
|              |                   | IN THE ORIGINAL COPIES ISSUED BY  |
|              |                   | THE EFED. IT IS POSSIBLE THAT THE |
|              |                   | TRANSFERENCE FROM WORD PERFECT TO |
|              |                   | PDF FORMAT COULD HAVE CAUSED THE  |
|              |                   | PROBLEM. THE EFED DEFERS THE      |
|              |                   | ISSUE TO THE SRRD, TO PROVIDE     |
|              |                   | HARD COPIES TO THE REGISTRANT.**  |
+--------------+-------------------+-----------------------------------+
|              | Page 27           | Page is blank.                    |
|              |                   |                                   |
|              |                   | **RESPONSE: THIS COULD BE CAUSED  |
|              |                   | BY THE USE OF A DIFFERENT PRINTER |
|              |                   | THAN THE ONE FROM WHICH THE       |
|              |                   | DOCUMENT IS PRODUCED. THE EFED    |
|              |                   | WILL TAKE PRECAUTIONS TO AVOID    |
|              |                   | THE PROBLEM IN THIS PHASE.**      |
+--------------+-------------------+-----------------------------------+
|              | Page 29           | Page is blank.                    |
|              |                   |                                   |
|              |                   | **RESPONSE: SAME AS ABOVE.**      |
+--------------+-------------------+-----------------------------------+

+--------------+-------------------+-----------------------------------+
| **Header**   | **pdf Version     | **Comments**                      |
|              | Page #; Paragraph |                                   |
|              | \#**              |                                   |
+--------------+-------------------+-----------------------------------+
| Exposure     | Page 31.          | We question why the Agency has    |
| Char         |                   | taken some of the representative  |
| acterization |                   | properties values for             |
| (Section III |                   | cypermethrin from the review by   |
| B)           |                   | (Laskowski, MRID 45169501) but    |
|              |                   | ignored others, e.g. kinetic      |
|              |                   | parameters, K~oc~ and BCF. If     |
|              |                   | EFED plans to include any         |
|              |                   | modeling, it is important that    |
|              |                   | they cover available published    |
|              |                   | peer reviewed papers -- including |
|              |                   | data from the Laskowski           |
|              |                   | publication.                      |
|              |                   |                                   |
|              |                   | **RESPONSE: THIS IS A SUBSTANTIVE |
|              |                   | ISSUE, NOT AN "ERROR ONLY," IT    |
|              |                   | WILL BE ADDRESSED IN THE NEXT     |
|              |                   | PHASE.**                          |
|              |                   |                                   |
|              |                   | Also, although the risk           |
|              |                   | assessment includes estuarine and |
|              |                   | marine ecosystems, there is no    |
|              |                   | attempt to derive an EEC for      |
|              |                   | estuarine and marine habitats.    |
|              |                   | Use of the high-exposure          |
|              |                   | farm-pond scenario as a surrogate |
|              |                   | for estuarine and marine          |
|              |                   | environments is extremely         |
|              |                   | conservative. **RESPONSE: THIS IS |
|              |                   | CORRECT. HOWEVER, THIS IS A       |
|              |                   | SUBSTANTIVE CORRECTION AND WILL   |
|              |                   | BE ADDRESSED LATER.**             |
+--------------+-------------------+-----------------------------------+
|              | Page 32.          | Soil adsorption: Table 5 shows    |
|              |                   | results of just one batch         |
|              |                   | equilibrium adsorption study with |
|              |                   | cypermethrin ( MRID 42129003,     |
|              |                   | Froelich, 1991). For the          |
|              |                   | PRZM/EXAMS runs, EFED used the    |
|              |                   | value of 141,700 for Koc, which   |
|              |                   | is claimed to be the average Koc  |
|              |                   | from the four values reported by  |
|              |                   | Froleich, 1991. Laskowski (2002)  |
|              |                   | finds that a more recent sorption |
|              |                   | study (Goggin *et al.*, 1996) is  |
|              |                   | more reliable than that of        |
|              |                   | Froelich 1991. This is because    |
|              |                   | the presence of cosolvent in the  |
|              |                   | Froelich study could have         |
|              |                   | resulted in an underestimation of |
|              |                   | cypermethrin sorption in this     |
|              |                   | case.                             |
|              |                   |                                   |
|              |                   | **RESPONSE: THIS IS A SUBSTANTIVE |
|              |                   | ISSUE, IT WILL BE ADDRESSED IN A  |
|              |                   | SUBSEQUENT REVISION PHASE.**      |
+--------------+-------------------+-----------------------------------+
|              | Page 32. Section  | First sentence                    |
|              | 1.a.              | "...zeta-cypermethrin, one of the |
|              | Environmental     | isomers of cypermethrin." This is |
|              | Fate and          | incorrect. Zeta-cypermethrin is   |
|              | Transport         | made up of the same eight isomers |
|              | Characterization. | that define cypermethrin, except  |
|              |                   | they are in different ratios for  |
|              |                   | the two products.                 |
|              |                   |                                   |
|              |                   | **RESPONSE: THE PARAGRAPH WAS     |
|              |                   | SIMPLIFIED, TO AVOID CONFUSION.** |
+--------------+-------------------+-----------------------------------+
| **Header**   | **pdf Version     | **Comments**                      |
|              | Page #; Paragraph |                                   |
|              | \#**              |                                   |
+--------------+-------------------+-----------------------------------+
|              | Page 32.          | Section 1.a. Environmental Fate   |
|              |                   | and Transport                     |
|              |                   | Characterization/Summary of       |
|              |                   | Empirical Data. It is stated here |
|              |                   | that "If released to water,       |
|              |                   | cypermethrin will rapidly         |
|              |                   | partition to the sediment         |
|              |                   | compartment which acts as an      |
|              |                   | environmental sink for this       |
|              |                   | compound." In natural water       |
|              |                   | bodies, cypermethrin will rapidly |
|              |                   | partition into organic matter     |
|              |                   | containing substrates, which in   |
|              |                   | addition to bed sediment, include |
|              |                   | phytoplankton, other suspended    |
|              |                   | particles and aquatic plants in   |
|              |                   | the water column. The relative    |
|              |                   | extent to which cypermethrin      |
|              |                   | reaching surface water will       |
|              |                   | partition to sediment will depend |
|              |                   | on the relative densities of      |
|              |                   | these other substrates in the     |
|              |                   | water body.                       |
|              |                   |                                   |
|              |                   | **RESPONSE: THIS IS NOT AN ERROR  |
|              |                   | ONLY; HOWEVER, A BRIEF SENTENCE   |
|              |                   | WAS ADDED TO ADDRESS THE          |
|              |                   | MATTER.**                         |
+--------------+-------------------+-----------------------------------+
| Exposure     | Page 34.          | Section 1. e. Field Studies. No   |
| Char         |                   | mentioned is made here of the     |
| acterization |                   | aquatic field studies with        |
| (Section III |                   | cypermethrin, although two of     |
| B)           |                   | these studies are referred to in  |
|              |                   | Section C. Ecological Effects     |
|              |                   | Characterization. For example,    |
|              |                   | the following field aquatic       |
|              |                   | studies area available:           |
|              |                   |                                   |
|              |                   | Crossland (1982). Aquatic         |
|              |                   | toxicology of cypermethrin. II.   |
|              |                   | Fate and biological effects in    |
|              |                   | pond experiments. Aquatic         |
|              |                   | Toxicol. 2:205-222.               |
|              |                   |                                   |
|              |                   | Crossland *et al.* (1982).        |
|              |                   | Aquatic toxicology of             |
|              |                   | cypermethrin. III. Fate and       |
|              |                   | biological effects of spray drift |
|              |                   | deposits in fresh water adjacent  |
|              |                   | to agricultural land. Aquatic     |
|              |                   | Toxicol. 2: 253-270.              |
|              |                   |                                   |
|              |                   | Farmer *et al.* (1995). A         |
|              |                   | comparison of the fate and        |
|              |                   | effects of two pyrethroid         |
|              |                   | insecticides (lambda-cyhalothrin  |
|              |                   | and cypermethrin) in pond         |
|              |                   | mesocosms. Ecotoxicology,         |
|              |                   | 4:219-244.                        |
|              |                   |                                   |
|              |                   | Shires & Bennett D (1985).        |
|              |                   | Contamination and effects in      |
|              |                   | freshwater ditches resulting from |
|              |                   | aerial application of             |
|              |                   | cypermethrin. Ecotoxicol Environ  |
|              |                   | Safety, 9:145-158.                |
|              |                   |                                   |
|              |                   | Getty *et al.* (1983).            |
|              |                   | Cypermethrin: effects of multiple |
|              |                   | low application rate applications |
|              |                   | on experimental ponds. ICI Plant  |
|              |                   | Protection Division, Bracknell,   |
|              |                   | Berks, UK. Report No. RJ0182B.    |
|              |                   | MRID 152737.                      |
|              |                   |                                   |
|              |                   | Jaber and Hawk (1983).            |
|              |                   | Cypermethrin: aquatic ecological  |
|              |                   | effects under field use           |
|              |                   | conditions in cotton, Selma,      |
|              |                   | Alabama, 1980. ICI Americas,      |
|              |                   | Inc., Goldsboro, NC. Report No.   |
|              |                   | TMUE0026/B. MRID 128704.          |
|              |                   |                                   |
|              |                   | Palmieri *et al.* (1992). An      |
|              |                   | evaluation of the impact of       |
|              |                   | cypermethrin exposure on managed  |
|              |                   | aquatic ecosystems. FMC           |
|              |                   | Corporation Study No. A89-2847.   |
|              |                   | MRID 42148201.                    |
|              |                   |                                   |
|              |                   | Rea *et al.* (1988).              |
|              |                   | Cypermethrin: evaluation of the   |
|              |                   | impact of aerially sprayed        |
|              |                   | cypermethrin on the aquatic       |
|              |                   | ecosystem of a farm pond in the   |
|              |                   | drainage basin of a cotton crop;  |
|              |                   | 1987. ICI Agrochemicals,          |
|              |                   | Bracknell, Berks, UK Report No.   |
|              |                   | RJ0629B. MRID 40804501.           |
|              |                   |                                   |
|              |                   | **RESPONSE: THIS IS A SUBSTANTIVE |
|              |                   | ISSUE, NOT AN ERROR CORRECTION.   |
|              |                   | IF THESE FIELD STUDIES HAVE       |
|              |                   | ENVIRONMENTAL FATE INFORMATION,   |
|              |                   | THEY MAY BE ADDED IN THIS SECTION |
|              |                   | IN A SUBSEQUENT PHASE.**          |
+--------------+-------------------+-----------------------------------+

+--------------+-------------------+-----------------------------------+
| **Header**   | **pdf Version     | **Comments**                      |
|              | Page #; Paragraph |                                   |
|              | \#**              |                                   |
+--------------+-------------------+-----------------------------------+
| Spray drift/ | Page 46           | Last paragraph, last sentence     |
| Buffer zone  |                   | should read "These scenarios are  |
| Analysis     |                   | summarized in Supplementary Table |
|              |                   | A."                               |
|              |                   |                                   |
|              |                   | **RESPONSE: AGREE, CORRECTED.**   |
+--------------+-------------------+-----------------------------------+
|              | Page 49           | The paragraph above Table D       |
|              |                   | references CA fruits (stone       |
|              |                   | fruits), which are not included   |
|              |                   | in this assessment. In addition,  |
|              |                   | cypermethrin is not registered on |
|              |                   | stone fruits.                     |
|              |                   |                                   |
|              |                   | **RESPONSE: AGREE, CORRECTED.**   |
+--------------+-------------------+-----------------------------------+
| S            | Page 49           | It is unclear why higher tiers of |
| upplementary |                   | refinement result in increasing   |
| Tables D and |                   | rather than decreasing estimated  |
| E            |                   | peak concentrations. The 0% drift |
|              |                   | peak value (2.155) is greater     |
|              |                   | than the peak value used in the   |
|              |                   | 5% drift PRZM/EXAMS runs (2.01).  |
|              |                   | To be consistent (and follow EFED |
|              |                   | policy), the 1 in 10 year         |
|              |                   | exceedence value should be used   |
|              |                   | in Tables D and E, especially     |
|              |                   | since RQ values are calculated    |
|              |                   | and apparently used in the        |
|              |                   | assessment.                       |
|              |                   |                                   |
|              |                   | **RESPONSE: THE PEAK VALUE FOR 5% |
|              |                   | DRIFT IS 2.385 ppb. EFED REVISED  |
|              |                   | ALL THE PEAK VALUES AND FOUND     |
|              |                   | THAT ALL OF THEM WERE CORRECTLY   |
|              |                   | REPORTED.**                       |
+--------------+-------------------+-----------------------------------+
| S            | Page 49           | The high-end conservative drift   |
| upplementary |                   | scenario includes a release       |
| Table E      |                   | height of 15 ft. The Ammo label   |
|              |                   | states those applications more    |
|              |                   | than 10 ft above the crop canopy  |
|              |                   | should be avoided.                |
|              |                   |                                   |
|              |                   | **RESPONSE: IT SHOULD BE AVOIDED, |
|              |                   | BUT IT IS POSSIBLE THAT THE       |
|              |                   | APPLICATOR WOULD EXCEED THIS      |
|              |                   | LIMIT.**                          |
+--------------+-------------------+-----------------------------------+
|              |                   | The very conservative drift       |
|              |                   | scenario is unrealistic. The use  |
|              |                   | of fine droplets with a wind      |
|              |                   | speed of 15 mph is unlikely.      |
|              |                   |                                   |
|              |                   | **RESPONSE: THIS SCENARIO IS ALSO |
|              |                   | POSSIBLE.**                       |
+--------------+-------------------+-----------------------------------+
|              | Page 51;1, last   | Please change "but it is more     |
|              | sentence          | meaningful for the high end drift |
|              |                   | scenario" to "but had a greater   |
|              |                   | impact for the high end drift     |
|              |                   | scenario".                        |
|              |                   |                                   |
|              |                   | **RESPONSE: THIS IS NOT AN ERROR  |
|              |                   | CORRECTION; HOWEVER, THE SENTENCE |
|              |                   | WAS REWORDED FOR CLARITY, BUT NOT |
|              |                   | ACCORDING TO THE REGISTRANT'S     |
|              |                   | RECOMMENDATION.**                 |
+--------------+-------------------+-----------------------------------+
|              | 51, 2, first      | Please change "has certain        |
|              | sentence          | uncertainties" to "specific       |
|              |                   | uncertainties".                   |
|              |                   |                                   |
|              |                   | **RESPONSE: AGREE.**              |
+--------------+-------------------+-----------------------------------+
| Aq Exposure  | Page 52; 1,       | Please insert "with log Pow of    |
| Monitoring   | Sentence 2        | 5.0" after "cypermethrin is very  |
| and Field    |                   | hydrophobic".                     |
| Data         |                   |                                   |
|              |                   | **RESPONSE: DISAGREE. THIS PHRASE |
|              |                   | DOES NOT ADD TO THE MESSAGE OF    |
|              |                   | THE PARAGRAPH. IN ADDITION THE    |
|              |                   | VALUE FOR log Pow APPEARS TO BE   |
|              |                   | INCORRECT.**                      |
+--------------+-------------------+-----------------------------------+

+--------------+---+-------------------+-----------------------------------+
| **Header**   | * |                   | **Comments**                      |
|              | * |                   |                                   |
|              | p |                   |                                   |
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|              | # |                   |                                   |
|              | * |                   |                                   |
|              | * |                   |                                   |
+--------------+---+-------------------+-----------------------------------+
| Ecological   | P |                   | a.  For the acute and chronic     |
| Effects      | a |                   |     toxicity reference values for |
| Char         | g |                   |     fish and invertebrates, EFED  |
| acterization | e |                   |     has selected the lowest       |
| (Section III | 5 |                   |     single endpoints. In this     |
| C)           | 4 |                   |     way, EFED are not taking      |
|              |   |                   |     advantage of the wealth of    |
|              |   |                   |     information contained within  |
|              |   |                   |     the numerous acceptable       |
|              |   |                   |     studies available with        |
|              |   |                   |     cypermethrin and fish and     |
|              |   |                   |     invertebrate species. Using   |
|              |   |                   |     geometric means from all of   |
|              |   |                   |     the acceptable study          |
|              |   |                   |     endpoints would provide more  |
|              |   |                   |     robust endpoints for risk     |
|              |   |                   |     assessment. **RESPONSE: THIS  |
|              |   |                   |     IS A SUBSTANTIVE COMMENT AND  |
|              |   |                   |     WILL BE ADDRESSED LATER.**    |
|              |   |                   |                                   |
|              |   |                   | b.  The acute fish and acute      |
|              |   |                   |     freshwater invertebrate       |
|              |   |                   |     endpoints selected by EFED    |
|              |   |                   |     are values for                |
|              |   |                   |     beta-cypermethrin.            |
|              |   |                   |     Beta-cypermethrin has an      |
|              |   |                   |     enhanced isomer composition,  |
|              |   |                   |     with an increased in the      |
|              |   |                   |     content of active isomers     |
|              |   |                   |     relative to cypermethrin.     |
|              |   |                   |     EFED have not explained or    |
|              |   |                   |     demonstrated why the          |
|              |   |                   |     ecotoxicity of beta           |
|              |   |                   |     cypermethrin is considered to |
|              |   |                   |     be equivalent to that of      |
|              |   |                   |     cypermethrin. **RESPONSE:     |
|              |   |                   |     BETA CYPERMETHRIN INFORMATION |
|              |   |                   |     WAS USED AS BRIDGING DATA.    |
|              |   |                   |     TOXICITY IS IN THE SAME RANGE |
|              |   |                   |     AS CYPERMETHRIN**             |
|              |   |                   |                                   |
|              |   |                   | c.  For the same reasons given in |
|              |   |                   |     point 5.b. above, some        |
|              |   |                   |     rationale is needed to        |
|              |   |                   |     justify EFED's comparison of  |
|              |   |                   |     the acute fish and            |
|              |   |                   |     invertebrate endpoints from   |
|              |   |                   |     tests with beta-cypermethrin  |
|              |   |                   |     with endpoints from tests     |
|              |   |                   |     with formulated cypermethrin. |
|              |   |                   |                                   |
|              |   |                   | **RESPONSE: BETA CYPERMETHRIN     |
|              |   |                   | INFORMATION WAS USED AS BRIDGING  |
|              |   |                   | DATA. TOXICITY IS IN THE SAME     |
|              |   |                   | RANGE AS CYPERMETHRIN**           |
|              |   |                   |                                   |
|              |   |                   | d.  EFED have estimated a NOAEC   |
|              |   |                   |     for *Daphnia* *magna* to be   |
|              |   |                   |     compared with a 21 day EEC,   |
|              |   |                   |     based on the acute to chronic |
|              |   |                   |     ratio for the mysid shrimp    |
|              |   |                   |     (96h LC~50~/28 d NOAEC). The  |
|              |   |                   |     21 day NOEC for *Daphnia*     |
|              |   |                   |     *magna*, available from the   |
|              |   |                   |     study by Edwards *et          |
|              |   |                   |     al.*(1981) is considered to   |
|              |   |                   |     be more reliable than the     |
|              |   |                   |     estimate obtained by EFED.    |
|              |   |                   |     **RESPONSE: THIS STUDY WAS    |
|              |   |                   |     NOT AVAILABLE TO EPA AND WILL |
|              |   |                   |     BE ADDRESSED AT A LATER       |
|              |   |                   |     TIME.**                       |
|              |   |                   |                                   |
|              |   |                   | e.  EFED have calculated a 10 d   |
|              |   |                   |     LC~50~ in pore water for      |
|              |   |                   |     benthic organisms based on    |
|              |   |                   |     the lowest available sediment |
|              |   |                   |     value (*Hyalella azteca* in   |
|              |   |                   |     1% ^o^C sediment). EFED have  |
|              |   |                   |     used a K~oc~ value of 141,700 |
|              |   |                   |     for this calculation. As      |
|              |   |                   |     discussed in points 1 and 4   |
|              |   |                   |     b, this Koc value is likely   |
|              |   |                   |     to be an underestimate. JOSE  |
|              |   |                   |                                   |
|              |   |                   | f.  EFED have estimated a chronic |
|              |   |                   |     endpoint for benthic          |
|              |   |                   |     organisms based on the acute  |
|              |   |                   |     to chronic ratio for the      |
|              |   |                   |     mysid shrimp (96h LC~50~/28 d |
|              |   |                   |     NOAEC). As EFED are aware,    |
|              |   |                   |     the Pyrethroid Working group  |
|              |   |                   |     is progressing a *(comments   |
|              |   |                   |     continued from previous       |
|              |   |                   |     page)* program of work agreed |
|              |   |                   |     with EFED including           |
|              |   |                   |     generation of additional      |
|              |   |                   |     acute and chronic ecotoxicity |
|              |   |                   |     data for sediment dwellers.   |
|              |   |                   |     These new data, which will be |
|              |   |                   |     available over the coming     |
|              |   |                   |     months, will be relevant to   |
|              |   |                   |     the environmental risk        |
|              |   |                   |     assessment for cypermethrin.  |
|              |   |                   |     **RESPONSE: AGREED.**         |
|              |   |                   |                                   |
|              |   |                   | It is worth noting that data are  |
|              |   |                   | also available on the acute       |
|              |   |                   | effects of cypermethrin on the    |
|              |   |                   | fresh water mollusk *Lymnaea      |
|              |   |                   | acuminate* (1986. Chemosphere     |
|              |   |                   | 15(4):493-498). The 96 h LC~50~   |
|              |   |                   | for *Lymnaea acuminate* is given  |
|              |   |                   | as 360 ppb, indicating that       |
|              |   |                   | freshwater mollusks are much less |
|              |   |                   | sensitive to cypermethrin than    |
|              |   |                   | arthropods (also true for marine  |
|              |   |                   | mollusks, see Table E-6).         |
+--------------+---+-------------------+-----------------------------------+
| **Header**   | * |                   | **Comments**                      |
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|              | # |                   |                                   |
|              | * |                   |                                   |
|              | * |                   |                                   |
+--------------+---+-------------------+-----------------------------------+
| Cypermethrin |   | Page 57, Table 12 | Acute rainbow trout 96-hr study   |
| Toxicity     |   |                   | (MRID 44546027) is a              |
| Reference    |   |                   | beta-Cypermethrin study           |
| Values       |   |                   |                                   |
|              |   |                   | beta-Cypermethrin studies should  |
|              |   |                   | not be used in estimating the     |
|              |   |                   | risk to cypermethrin. **RESPONSE: |
|              |   |                   | BETA CYPERMETHRIN INFORMATION WAS |
|              |   |                   | USED AS BRIDGING DATA. TOXICITY   |
|              |   |                   | IS IN THE SAME RANGE AS           |
|              |   |                   | CYPERMETHRIN**                    |
+--------------+---+-------------------+-----------------------------------+
| Table 12     |   | Page 57           | Daphnia acute study MRID 44546031 |
|              |   |                   | is stated to be a                 |
|              |   |                   | beta-cypermethrin study in        |
|              |   |                   | Appendix E (p-E16).               |
|              |   |                   | beta-Cypermethrin studies should  |
|              |   |                   | not be used in estimating the     |
|              |   |                   | risk to cypermethrin. **RESPONSE: |
|              |   |                   | BETA CYPERMETHRIN INFORMATION WAS |
|              |   |                   | USED AS BRIDGING DATA. TOXICITY   |
|              |   |                   | IS IN THE SAME RANGE AS           |
|              |   |                   | CYPERMETHRIN**                    |
+--------------+---+-------------------+-----------------------------------+
|              |   | Page 58,          | Accession. No. 070562 is an       |
|              |   | estuarine/marine  | oyster study according to Table   |
|              |   | invertebrates;    | E-6 on page E-37. The Reference   |
|              |   | Acute, mysid      | should be MRID 42444601           |
|              |   | shrimp            |                                   |
|              |   |                   | **RESPONSE: CORRECTED**           |
+--------------+---+-------------------+-----------------------------------+
| a\. (1)      |   | Page 60, 1^st^    | Remove 0.39 ug/L for trout, that  |
| Acute        |   | sentence          | study (MRID 44546027) is a        |
| Effects      |   |                   | beta-cypermethrin study.          |
|              |   |                   | beta-Cypermethrin studies should  |
|              |   |                   | not be used in estimating         |
|              |   |                   | cypermethrin risk. **RESPONSE:    |
|              |   |                   | THIS ISSUE HAS BEEN ADDRESSED     |
|              |   |                   | EARLIER.**                        |
+--------------+---+-------------------+-----------------------------------+
|              |   | Page 60,          | Need to mention GFU 061 (36 %),   |
|              |   | paragraph 2,      | which is mentioned in the next    |
|              |   | 2^nd^ sentence    | sentence. **RESPONSE: THIS HAS    |
|              |   |                   | BEEN CORRECTED.**                 |
+--------------+---+-------------------+-----------------------------------+
|              |   | Page 60, 2^nd^    | It is unclear where the 3.3 value |
|              |   | paragraph, 6^th^  | is derived from in Table E-1b.    |
|              |   | line              | **RESPONSE: CORRECTED**           |
+--------------+---+-------------------+-----------------------------------+
|              |   | Page 60, 4^th^    | Remove 0.42 ug/L for daphnia that |
|              |   | paragraph         | study (MRID 4456031) is a         |
|              |   |                   | beta-cypermethrin study.          |
|              |   |                   | beta-Cypermethrin studies should  |
|              |   |                   | not be used in estimating         |
|              |   |                   | cypermethrin risk. **RESPONSE:    |
|              |   |                   | BETA CYPERMETHRIN INFORMATION WAS |
|              |   |                   | USED AS BRIDGING DATA. TOXICITY   |
|              |   |                   | IS IN THE SAME RANGE AS           |
|              |   |                   | CYPERMETHRIN**                    |
+--------------+---+-------------------+-----------------------------------+
|              |   | Page 61,          | Table E-5 page E-33 list the      |
|              |   | paragraph under   | Atlantic salmon LC50 value as 2.0 |
|              |   | Estuarine/Marine  | and the reference should be       |
|              |   | Fish , 1^st^      | 41068003 not 41968212.            |
|              |   | sentence          |                                   |
|              |   |                   | **RESPONSE: CORRECTED**           |
+--------------+---+-------------------+-----------------------------------+
| \(3\)        |   | Page 66; 1        | MRID 44546031 is a                |
| Sublethal    |   |                   | beta-Cypermethrin study.          |
| Effects      |   |                   | beta-Cypermethrin studies should  |
|              |   |                   | not be used in estimating         |
|              |   |                   | cypermethrin risk.                |
|              |   |                   |                                   |
|              |   |                   | **RESPONSE: BETA CYPERMETHRIN     |
|              |   |                   | INFORMATION WAS USED AS BRIDGING  |
|              |   |                   | DATA. TOXICITY IS IN THE SAME     |
|              |   |                   | RANGE AS CYPERMETHRIN**           |
+--------------+---+-------------------+-----------------------------------+
|              |   | 66, 1^st^ full    | LC50 in rainbow trout should be   |
|              |   | paragraph         | mentioned (13 ug/L). Sublethal    |
|              |   |                   | effects for the formulated        |
|              |   |                   | material are not similar to the   |
|              |   |                   | technical material. There are not |
|              |   |                   | orders of magnitude differences   |
|              |   |                   | between the NOAEC and the LC50    |
|              |   |                   | value for the formulated          |
|              |   |                   | material.                         |
|              |   |                   |                                   |
|              |   |                   | **RESPONSE: CORRECTED. There was  |
|              |   |                   | a units mistake in table E-1a**   |
+--------------+---+-------------------+-----------------------------------+
|              |   | 66, 4^th^ line    | MRID number 44546034 is a         |
|              |   | under             | beta-cypermethrin study.          |
|              |   | Estuarine/Marine  | beta-Cypermethrin studies should  |
|              |   | Fish -            | not be used in estimating         |
|              |   |                   | cypermethrin risk.                |
|              |   |                   |                                   |
|              |   |                   | **RESPONSE: BETA CYPERMETHRIN     |
|              |   |                   | INFORMATION WAS USED AS BRIDGING  |
|              |   |                   | DATA. TOXICITY IS IN THE SAME     |
|              |   |                   | RANGE AS CYPERMETHRIN**           |
+--------------+---+-------------------+-----------------------------------+
|              |   | 66, first line    | Table E-5 should be E-4.          |
|              |   | under Benthic     |                                   |
|              |   | Organisms         |                                   |
+--------------+---+-------------------+-----------------------------------+

+--------------+-----------------+------------------------------------+
| **Header**   | **pdf Version   | **Comments**                       |
|              | Page #;         |                                    |
|              | Paragraph \#**  |                                    |
+--------------+-----------------+------------------------------------+
| Section III  | Page 67.        | The open literature paper Kedwards |
| C (4) field  |                 | *et al.*(1999a) provides further   |
| studies      |                 | statistical analyses of the study  |
|              |                 | reported by Rea *et al.* (1988)    |
|              |                 | and the paper Kedwards *et         |
|              |                 | al.*(1999b) provides further       |
|              |                 | statistical analyses of the study  |
|              |                 | reported by Farmer *et al.*        |
|              |                 | (1995). EFED have included a       |
|              |                 | summary of the study by Farmer *et |
|              |                 | al.* (1995) in Table E-8, however  |
|              |                 | EFED have not summarized the study |
|              |                 | by Rea *et al.*(1988) ICI report   |
|              |                 | number RJ0629B, MRID 40804501.     |
|              |                 |                                    |
|              |                 | **RESPONSE: THIS IS A SUBSTANTIVE  |
|              |                 | COMMENT AND WILL BE ADDRESSED      |
|              |                 | LATER.**                           |
+--------------+-----------------+------------------------------------+
| Table 13     | Page 69         | Chronic rat study -- The           |
|              |                 | acceptable MRID# 00112912 should   |
|              |                 | be used for endpoint comparisons   |
|              |                 | in place of the unacceptable /     |
|              |                 | supplemental study currently being |
|              |                 | used in this assessment (MRID      |
|              |                 | 00090040).                         |
|              |                 |                                    |
|              |                 | Change throughout the text and use |
|              |                 | the correct endpoint for           |
|              |                 | calculating the RQs                |
|              |                 |                                    |
|              |                 | **RESPONSE: EFED POLICY IS TO USE  |
|              |                 | THE MOST SENATIVE ORGANISMS.       |
|              |                 | SUPLLEMENTAL DATA IS ACCEPTABLE**  |
|              |                 | **FOR RISK ASSESSMENT              |
|              |                 | DEVELOPMENT.**                     |
+--------------+-----------------+------------------------------------+
|              |                 | MRID 44546024 a beta study.        |
|              |                 | beta-Cypermethrin studies should   |
|              |                 | not be used in estimating          |
|              |                 | cypermethrin risk.                 |
|              |                 |                                    |
|              |                 | **RESPONSE: THIS HAS BEEN          |
|              |                 | ADDRESSED PREVIOUSLY.**            |
+--------------+-----------------+------------------------------------+
|              |                 | Acute dietary avian the actual     |
|              |                 | reported LC50 was \> 20,000 ppm    |
|              |                 | rather than the reported repellent |
|              |                 | effect concentration of \> 2,634   |
|              |                 | ppm in the text. Change throughout |
|              |                 | the text and use the correct       |
|              |                 | endpoint (\> 20, 000) for          |
|              |                 | calculating the RQs**.** []{.mark} |
|              |                 |                                    |
|              |                 | **RESPONSE: CORRECTED**            |
+--------------+-----------------+------------------------------------+
| Terrestrial  | Page 70         | MRID 44544208 is a                 |
| I            |                 | beta-cypermethrin study for        |
| nvertebrates |                 | honeybees (last sentence in this   |
|              |                 | section). beta-Cypermethrin        |
|              |                 | studies should not be used in      |
|              |                 | estimating cypermethrin risk.      |
|              |                 |                                    |
|              |                 | **RESPONSE: BETA CYPERMETHRIN      |
|              |                 | INFORMATION WAS USED AS BRIDGING   |
|              |                 | DATA. TOXICITY IS IN THE SAME      |
|              |                 | RANGE AS CYPERMETHRIN**            |
+--------------+-----------------+------------------------------------+
|              | Page 72.        | Page is blank.                     |
|              |                 |                                    |
|              |                 | **REFER TO RESPONSE TO THIS ISSUE  |
|              |                 | ABOVE.**                           |
+--------------+-----------------+------------------------------------+
| Risk         | Page 73         | As EFED are aware, the Pyrethroid  |
| Char         |                 | Working group is progressing a     |
| acterization |                 | program of work agreed with EFED   |
| (Section IV) |                 | including the development of       |
|              |                 | refined exposure estimates based   |
|              |                 | on the best available usage data,  |
|              |                 | generation of additional acute and |
|              |                 | chronic ecotoxicity data for       |
|              |                 | sediment dwellers and the          |
|              |                 | compilation of a comprehensive     |
|              |                 | ecotoxicity data review for the    |
|              |                 | synthetic pyrethroids. These new   |
|              |                 | data and assessments, which will   |
|              |                 | be available over the coming       |
|              |                 | months, will be relevant to the    |
|              |                 | environmental risk assessment for  |
|              |                 | cypermethrin.                      |
|              |                 |                                    |
|              |                 | **RESPONSE: THE AGENCY IS AWARE OF |
|              |                 | PWG'S EFFORTS, ESPECIALLY, THEIR   |
|              |                 | SEDIMENT TOXICITY STUDIES.**       |
+--------------+-----------------+------------------------------------+
| **Header**   | **pdf Version   | **Comments**                       |
|              | Page #;         |                                    |
|              | Paragraph \#**  |                                    |
+--------------+-----------------+------------------------------------+
| 1\.          | Page 74         | The 21-day EEC is being used       |
| Non-target   |                 | solely to calculate RQs and it is  |
| aquatic...   |                 | recommended that other values as   |
|              |                 | listed below be included in RQ     |
|              |                 | calculations (i.e. daphnia 21      |
|              |                 | days, fish +28 days).              |
|              |                 |                                    |
|              |                 | **RESPONSE: EFED HAS CHANGED THE   |
|              |                 | CHRONIC RQ VALUES TO REFLECT THE   |
|              |                 | EEC FOR 60 DAYS IN ORDER TO        |
|              |                 | CALCULATE CHRONIC RQS FOR FISH.**  |
+--------------+-----------------+------------------------------------+
| Table 15     | Page 76         | The freshwater invertebrate        |
|              |                 | chronic RQ for TX cotton should be |
|              |                 | 0.9 and not 1.1. This means that   |
|              |                 | the RQ does not exceed the LOC for |
|              |                 | chronic risk.                      |
|              |                 |                                    |
|              |                 | **RESPONSE: CORRECTED**            |
+--------------+-----------------+------------------------------------+
| S            | Page 77         | The values used here should be the |
| upplementary |                 | 1 in 10 year exceedence EECs, just |
| Table H      |                 | like those used for the RQ         |
|              |                 | calculations previously.           |
|              |                 |                                    |
|              |                 | **RESPONSE: THIS ISSUE WAS         |
|              |                 | PREVIOUSLY ADDRESSED. THE CORRECT  |
|              |                 | VALUES WERE REPORTED.**            |
+--------------+-----------------+------------------------------------+
| c\. Use of   | Page 77         | Should include a freshwater        |
| buffer zones |                 | species also to compare buffer     |
|              |                 | zones.                             |
|              |                 |                                    |
|              |                 | **RESPONSE: THIS IS A SUBSTANTIVE  |
|              |                 | ISSUE, NOT AN ERROR, IT WILL BE    |
|              |                 | CONSIDERED IN A SUBSEQUENT         |
|              |                 | PHASE.**                           |
+--------------+-----------------+------------------------------------+
|              | Page 78         | The 1 in 10 year exceedence values |
|              |                 | should be used for RQ comparisons. |
|              |                 |                                    |
|              |                 | **RESPONSE ALREADY PROVIDED.**     |
|              |                 |                                    |
|              |                 | The RQs calculated here (based     |
|              |                 | upon peak concentrations) should   |
|              |                 | not be compared to the LOCs if     |
|              |                 | they are used to study the impact  |
|              |                 | of spray drift on concentrations.  |
|              |                 |                                    |
|              |                 | **RESPONSE: THIS IS NOT AN ERROR   |
|              |                 | CORRECTION, THIS ISSUE WILL BE     |
|              |                 | ADDRESSED IN A SUBSEQUENT PHASE.** |
+--------------+-----------------+------------------------------------+
|              |                 | The text should note that a        |
|              |                 | 150-foot buffer zone is required   |
|              |                 | by the label, and that the values  |
|              |                 | presented only take into account   |
|              |                 | reduction of spray drift, and not  |
|              |                 | runoff and sediment transport,     |
|              |                 | which are significant.             |
|              |                 |                                    |
|              |                 | **RESPONSE: THIS IS NOT AN ERROR;  |
|              |                 | HOWEVER, THE EFED ADDED A FOOTNOTE |
|              |                 | IN SUPPLEMENTARY TABLE I.**        |
+--------------+-----------------+------------------------------------+
| Table 17     | Page 81         | The footnotes reference T-REX      |
|              |                 | output in Appendix D, but the      |
|              |                 | output was not included in the     |
|              |                 | appendix. (Microsoft Excel         |
|              |                 | spreadsheets not included (Page    |
|              |                 | D-1)                               |
|              |                 |                                    |
|              |                 | **RESPONSE: CORRECTED**            |
+--------------+-----------------+------------------------------------+
| c\. Risk to  | Page 85         | Remove reference to beta           |
| Terrestrial  |                 | cypermethrin 10EC.                 |
| I            |                 | beta-Cypermethrin studies should   |
| nvertebrates |                 | not be used in estimating          |
|              |                 | cypermethrin risk.                 |
|              |                 |                                    |
|              |                 | **RESPONSE: BETA CYPERMETHRIN      |
|              |                 | INFORMATION WAS USED AS BRIDGING   |
|              |                 | DATA. TOXICITY IS IN THE SAME**    |
+--------------+-----------------+------------------------------------+
| **Header**   | **pdf Version   | **Comments**                       |
|              | Page #;         |                                    |
|              | Paragraph \#**  |                                    |
+--------------+-----------------+------------------------------------+
| Risk         | Page 85         | a\. EFED refers to available field |
| Description  |                 | studies and claims that these show |
| (Section IV  |                 | that adverse effects on sediment   |
| B)           |                 | dwelling populations can occur.    |
|              |                 | Giddings (1997) carried out a      |
|              |                 | thorough review of the available   |
|              |                 | field data on pyrethroids          |
|              |                 | (Springborn Report number          |
|              |                 | 97-6-7014) and this report we also |
|              |                 | published (Giddings *et al.*,      |
|              |                 | 2001. Probabilistic risk           |
|              |                 | assessment of cotton pyrethroids:  |
|              |                 | ii. Aquatic mesocosm and field     |
|              |                 | studies. Environmental Toxicology  |
|              |                 | and Chemistry, Vol. 20, No. 3, pp. |
|              |                 | 660--668). The findings of this    |
|              |                 | review were that the abundance of  |
|              |                 | macroinvertebrates in sediments    |
|              |                 | was highly variable in space and   |
|              |                 | time and could not be              |
|              |                 | characterized precisely for most   |
|              |                 | species. Additionally,             |
|              |                 | concentrations of pyrethroids in   |
|              |                 | sediments showed high special      |
|              |                 | variability, even following        |
|              |                 | uniform dosing of experimental     |
|              |                 | ponds. The review revealed that    |
|              |                 | areas of low or negligible         |
|              |                 | pyrethroid concentration in the    |
|              |                 | sediment can serve as refuges for  |
|              |                 | sediment dwellers and serve as     |
|              |                 | sources for population             |
|              |                 | recolonization. Overall, effects   |
|              |                 | of pyrethroids observed in the     |
|              |                 | mesocosms were correlated with     |
|              |                 | maximum concentrations in the      |
|              |                 | water column, not with             |
|              |                 | concentrations in the sediment.    |
|              |                 | Although some of the groups of     |
|              |                 | organisms affected by pyrethroid   |
|              |                 | application spend time in the      |
|              |                 | sediment surface, their most       |
|              |                 | relevant route of exposure would   |
|              |                 | be via the water column.           |
|              |                 |                                    |
|              |                 | b\. EFED express concerns about    |
|              |                 | the potential for bioaccumulation  |
|              |                 | in aquatic organisms and trophic   |
|              |                 | transfer. The PWG carried out a    |
|              |                 | program of work to investigate the |
|              |                 | partitioning, bioavailability and  |
|              |                 | toxicity of cypermethrin on        |
|              |                 | aquatic systems (PWG Report number |
|              |                 | RC0007; MRID 44074407). This work  |
|              |                 | was also published (Maund *et      |
|              |                 | al.*, 2002. Partitioning,          |
|              |                 | bioavailability and toxicity of    |
|              |                 | the pyrethroid insecticide         |
|              |                 | cypermethrin in sediments.         |
|              |                 | Environmental Toxicology and       |
|              |                 | Chemistry, Vol. 21 (1), pp. 9-15). |
|              |                 | These studies showed that in       |
|              |                 | water-sediment systems the vast    |
|              |                 | majority of the cypermethrin       |
|              |                 | (\>99%) is sorbed to the sediment. |
|              |                 | However, the concentration of      |
|              |                 | cypermethrin in the sediment is    |
|              |                 | not a good predictor of the amount |
|              |                 | that is bioavailable. The best     |
|              |                 | predictor of the bioavailable      |
|              |                 | fraction was the concentration in  |
|              |                 | the                                |
|              |                 |                                    |
|              |                 | pore water, supporting the         |
|              |                 | equilibrium partitioning theory.   |
|              |                 | Bioconcentration factors for       |
|              |                 | *Daphnia* and *Chironomus*, based  |
|              |                 | on the extractable concentration   |
|              |                 | of cypermethrin in sediment were   |
|              |                 | similar and very low (\<1),        |
|              |                 | indicating that the proportion of  |
|              |                 | the cypermethrin adsorbed to the   |
|              |                 | sediment that is available to      |
|              |                 | aquatic organisms is very low, for |
|              |                 | both water column and benthic      |
|              |                 | organisms.                         |
+--------------+-----------------+------------------------------------+
| **Header**   | **pdf Version   | **Comments**                       |
|              | Page #;         |                                    |
|              | Paragraph \#**  |                                    |
+--------------+-----------------+------------------------------------+
| b\. Aquatic  | Page 88,        | Hill et al 1973 and Dianne (change |
| Animals      | paragraph 2     | to Dionne) 1998 are incomplete     |
| (Water...)   |                 | references and are not in the      |
|              |                 | reference section on page 113.     |
|              |                 |                                    |
|              |                 | **RESPONSE: THIS IS NOT AN ERROR   |
|              |                 | CORRECTION. THE ISSUE WILL BE      |
|              |                 | CONSIDERED IN A SUBSEQUENT         |
|              |                 | PHASE.**                           |
+--------------+-----------------+------------------------------------+
|              | Page 89, 1^st^  | The sentence beginning with        |
|              | partial         | "effects include" is confusing and |
|              | paragraph,      | contains incomplete MRID #15.      |
|              | 8^th^ line from |                                    |
|              | bottom          | **RESPONSE: CORRECTED**            |
+--------------+-----------------+------------------------------------+
| c\. Aquatic  | Page 88, 1^st^  | Refer to Table E-8 (page E-46)     |
| Animals      | sentence in     | here.                              |
| (            | last paragraph  |                                    |
| Sediment...) |                 | **RESPONSE: CORRECTED**            |
+--------------+-----------------+------------------------------------+
| E. Other     | Page 89, last   | The sentence is confusing. Please  |
| special...   | sentence that   | reword.                            |
|              | extends to page |                                    |
|              | 90              | **RESPONSE: EVEN THOUGH THIS IS    |
|              |                 | NOT AN ERROR CORRECTION, THE       |
|              |                 | REVIEWER MODIFIED THE SENTENCE FOR |
|              |                 | CLARITY.**                         |
+--------------+-----------------+------------------------------------+
| e\. Other    | Page 90; 1      | "All scenarios showed that the RQ  |
| Special      |                 | exceeded by far all the LOCs." It  |
| Co           |                 | is suggested that sentence be      |
| nsiderations |                 | omitted. The exercise was to look  |
| for          |                 | at the impact of drift on EECs.    |
| Evaluating   |                 | The EECs from the drift exercise   |
| Aquatic Risk |                 | were higher than those with the    |
| (Buffer      |                 | standard 5% drift.                 |
| Zones)       |                 |                                    |
|              |                 | **RESPONSE: THIS IS NOT AN ERROR   |
|              |                 | CORRECTION. THE ISSUE WILL BE      |
|              |                 | CONSIDERED IN A SUBSEQUENT         |
|              |                 | PHASE.**                           |
+--------------+-----------------+------------------------------------+
|              | Page 90; 3      | This entire paragraph should be    |
|              |                 | amended to not include RQ values   |
|              |                 | since this was not the purpose of  |
|              |                 | the drift evaluation.              |
|              |                 |                                    |
|              |                 | **SAME RESPONSE AS ABOVE.**        |
+--------------+-----------------+------------------------------------+
| Summary of   | Pages 90-91.    | The final section of the aquatic   |
| Risk to      |                 | risk assessment is entirely        |
| Aquatic      |                 | speculative and out of place as    |
| Systems      |                 | the summary of a careful           |
| (IV.B.1.f)   |                 | quantitative screening-level risk  |
|              |                 | assessment. None of the            |
|              |                 | toxicological or ecological        |
|              |                 | phenomena invoked here is specific |
|              |                 | to cypermethrin or indeed to       |
|              |                 | pesticides in general. For         |
|              |                 | example, EFED states, "Possible    |
|              |                 | chronic effects to aquatic life    |
|              |                 | may also be a concern where an     |
|              |                 | initial permethrin exposure may be |
|              |                 | affective \[sic\] in causing       |
|              |                 | reproductive effects 21 days to 60 |
|              |                 | days later." The potential for     |
|              |                 | latent effects is a source of      |
|              |                 | uncertainty in most chemical risk  |
|              |                 | assessments. Another example:      |
|              |                 | "Toxic exposure of cypermethrin in |
|              |                 | the sediment can present a more    |
|              |                 | far reaching impact to a multitude |
|              |                 | of organisms than impact from the  |
|              |                 | water column" because many aquatic |
|              |                 | species interact with the sediment |
|              |                 | or with sediment-dwelling          |
|              |                 | organisms. Or: "Chronic toxicant   |
|              |                 | loads in sediments may drive       |
|              |                 | populations toward a limited set   |
|              |                 | of tolerant genotypes over time."  |
|              |                 | Such speculations are boundless;   |
|              |                 | one can use basic ecological       |
|              |                 | mechanisms to hypothesize about    |
|              |                 | indirect effects, which are        |
|              |                 | rarely, if ever, observed in field |
|              |                 | experiments. None of the factors   |
|              |                 | mentioned in this paragraph are    |
|              |                 | supported or suggested by the      |
|              |                 | findings of the Science Chapter -- |
|              |                 | they should have been addressed in |
|              |                 | the Problem Formulation.           |
|              |                 |                                    |
|              |                 | **RESPONSE: THIS IS NOT AN ERROR   |
|              |                 | CORRECTION. THE ISSUE WILL BE      |
|              |                 | CONSIDERED IN A SUBSEQUENT         |
|              |                 | PHASE.**                           |
+--------------+-----------------+------------------------------------+
| **Header**   | **pdf Version   | **Comments**                       |
|              | Page #;         |                                    |
|              | Paragraph \#**  |                                    |
+--------------+-----------------+------------------------------------+
| 3\. Review   | Page 93, 1^st^  | EPA lists 5 categories here, but   |
| of Incident  | full sentence   | on pages J1 and J2 the Agency      |
| Data         |                 | lists 6 categories in the          |
|              |                 | certainty index. Category 3        |
|              |                 | (probably) -- may need to be       |
|              |                 | eliminated.                        |
|              |                 |                                    |
|              |                 | **RESPONSE:CORRECTED**             |
+--------------+-----------------+------------------------------------+
| a\.          | Page 93, 3^rd^  | Related to above comment. Table    |
| Incidents    | sentence        | J-1 on page J2 does not reflect    |
| Involving    |                 | what is stated here. Footnote a    |
| Aquatic      |                 | (certainty index) has a 3 as       |
| Organisms.   |                 | probably. This throws the tally in |
|              |                 | this sentence off. If probably is  |
|              |                 | removed from the table, the number |
|              |                 | of various incidents reflects what |
|              |                 | is stated in this sentence         |
|              |                 |                                    |
|              |                 | **RESPONSE:CORRECTED**             |
+--------------+-----------------+------------------------------------+
| b\.          | Page 93, 3^rd^  | Similar to above comment. Table    |
| Incidents    | sentence        | J-1 on page J-1 has the 'probably' |
| Involving    |                 | in the footnote that makes this    |
| Terrestrial  |                 | sentence inaccurate. Footnote in   |
| Organisms    |                 | table J-1 needs to be corrected.   |
|              |                 |                                    |
|              |                 | **RESPONSE:CORRECTED**             |
+--------------+-----------------+------------------------------------+
| 4\.          | Page 93-94      | Current EFED work is ongoing to    |
| Endocrine    |                 | determine potential endocrine      |
| effects      |                 | effects from pesticides.           |
|              |                 | Conclusions about potential        |
|              |                 | effects at this point are          |
|              |                 | premature for cypermethrin.        |
|              |                 |                                    |
|              |                 | **RESPONSE: THE AGENCY CONCLUDES   |
|              |                 | THAT AT THIS SCREENING LEVEL       |
|              |                 | CYPERMETHRIN MAY HAVE THE          |
|              |                 | POTENTIAL FOR ENDOCRINE EFFECTS    |
|              |                 | (E.G., REPRODUCTION EFFECTS IN     |
|              |                 | AQUATIC ORGANISMS. WHEN            |
|              |                 | APPROPRIATE SCREENING AND TESTING  |
|              |                 | PROTOCOLS ARE DEVELOPED            |
|              |                 | CYPERMETHRIN MAY BE SUBJECTED TO   |
|              |                 | ADDITIONAL SCREENING.**            |
+--------------+-----------------+------------------------------------+
| Endocrine    | Page 93         | a\. EFED states that observed      |
| Effects      |                 | reproductive effects in aquatic    |
|              |                 | species are considered evidence of |
|              |                 | detrimental effects on the         |
|              |                 | endocrine system. The science      |
|              |                 | behind this assumption is not      |
|              |                 | revealed. **RESPONSE: THIS HAS     |
|              |                 | BEEN REVISED TO SHOW THAT          |
|              |                 | CYPERMETHRIN MAY HAVE EFFECTS ON   |
|              |                 | THE ENDROCRINE SYSTEM.**           |
|              |                 |                                    |
|              |                 | b\. Reproductive effects were      |
|              |                 | observed only for *M. bahia*,      |
|              |                 | based on the toxicity data         |
|              |                 | presented in Appendix E. This      |
|              |                 | estuarine/marine invertebrate was  |
|              |                 | the most sensitive species to      |
|              |                 | cypermethrin. However, for *M.     |
|              |                 | bahia* the lowest chronic endpoint |
|              |                 | was reduced growth in the males.   |
|              |                 |                                    |
|              |                 | **RESPONSE: REPRODUCTIVE EFFECTS   |
|              |                 | (GROWTH, ETC) ARE CONSIDERED AS    |
|              |                 | REFLECTIVE OF POSSIBLE EFFECTS TO  |
|              |                 | THE ENDOCRINE SYSTEM**.            |
+--------------+-----------------+------------------------------------+
| 5\.          | Pages 94- 98    | There appears to be several        |
| Threatened & |                 | sections missing including, (2)    |
| End          |                 | Probit Dose Response Relationship, |
| angered...., |                 | (3) Data Related to                |
| b. Taxonomic |                 | Under-represented Taxa and (4).    |
| G            |                 | Implications of Sublethal Effects. |
| roups...thru |                 | Also c. Indirect Effects Analysis. |
| to d.        |                 |                                    |
| Critical     |                 | **RESPONSE: AGREE, THESE WERE      |
| Habitat      |                 | DELETED FROM THE TABLE OF          |
|              |                 | CONTENTS.**                        |
+--------------+-----------------+------------------------------------+
| Threatened   | Page 94         | Syngenta and FMC acknowledge the   |
| and          |                 | data requirement for endangered    |
| Endangered   |                 | species to provide information on  |
| Species      |                 | the proximity of federally listed  |
|              |                 | endangered species to pesticide    |
|              |                 | use sites. Syngenta, FMC and other |
|              |                 | registrants responding to this     |
|              |                 | data requirement should provide    |
|              |                 | this endangered species            |
|              |                 | information using the FIFRA        |
|              |                 | Endangered Species Task Force      |
|              |                 | (FESTF) Information Management     |
|              |                 | System (IMS). FESTF has developed  |
|              |                 | the IMS to assist its member       |
|              |                 | companies in meeting legal         |
|              |                 | obligations to submit data         |
|              |                 | required by EPA-OPP under FIFRA    |
|              |                 | (as described in Pesticide         |
|              |                 | Registration Notice 2000-2) to     |
|              |                 | support the members' registration  |
|              |                 | and re-registration actions. The   |
|              |                 | purpose of the IMS is to meet the  |
|              |                 | data requirements in a manner that |
|              |                 | significantly improves the         |
|              |                 | consistency, quality, availability |
|              |                 | and use of existing information on |
|              |                 | threatened and endangered species  |
|              |                 | and pesticide use. On March 01,    |
|              |                 | 2005 FESTF submitted the work      |
|              |                 | products detailed in PR Notice     |
|              |                 | 2000-2, including IMS 2.0 and      |
|              |                 | access to NatureServe data on      |
|              |                 | endangered species in response to  |
|              |                 | the requirements described in that |
|              |                 | notice[^1]. Use of the IMS by      |
|              |                 | registrants in response to their   |
|              |                 | endangered species data            |
|              |                 | requirement for cypermethrin will  |
|              |                 | provide a means of conserving      |
|              |                 | EPA-OPP resources and providing    |
|              |                 | documentation and consistency      |
|              |                 | throughout to produce a high       |
|              |                 | quality effects determination for  |
|              |                 | cypermethrin.                      |
|              |                 |                                    |
|              |                 | > EPA has provided an explanation  |
|              |                 | > of the trigger for the           |
|              |                 | > endangered species data          |
|              |                 | > requirement, i.e., LOCs for      |
|              |                 | > endangered species that are      |
|              |                 | > exceeded in screening-level risk |
|              |                 | > assessments. However, EPA does   |
|              |                 | > not clearly articulate the data  |
|              |                 | > requirement for endangered       |
|              |                 | > species. **RESPONSE: THERE ARE   |
|              |                 | > NO SPECIFIC ENDANGERED SPECIES   |
|              |                 | > DATA REQUIREMENTS. THE AGENCY    |
|              |                 | > USES AVAILABLE DATA AND          |
|              |                 | > EXTRAPOLATED INFORMATION TO      |
|              |                 | > SCREEN-OUT THE LIKELYHOOD OF NO  |
|              |                 | > EFFECT. EXCEEDANCE OF THE        |
|              |                 | > ENDANGERED LOC TRIGGERS          |
|              |                 | > SCREENING LEVEL CONCERNS THAT    |
|              |                 | > ARE IDENTIFIED.**                |
|              |                 | >                                  |
|              |                 | > Participation in FESTF through   |
|              |                 | > membership or citation to FESTF  |
|              |                 | > work products provides a         |
|              |                 | > registrant with access to        |
|              |                 | > excellent tools necessary to     |
|              |                 | > complete a high quality          |
|              |                 | > endangered species assessment    |
|              |                 | > but does not provide specific    |
|              |                 | > information on the proximity of  |
|              |                 | > listed species to cypermethrin   |
|              |                 | > uses. EPA needs to provide       |
|              |                 | > better *(comments continued from |
|              |                 | > previous page)* guidance on what |
|              |                 | > the registrants need to deliver. |
|              |                 | >                                  |
|              |                 | > EPA needs to outline its plans   |
|              |                 | > for refinements to the           |
|              |                 | > screening-level risk assessment  |
|              |                 | > for cypermethrin. Refinements to |
|              |                 | > the screening-level assessment   |
|              |                 | > that reduce the scope of the     |
|              |                 | > effects determination for        |
|              |                 | > endangered species should be a   |
|              |                 | > high priority (e.g., terrestrial |
|              |                 | > vertebrates).                    |
|              |                 | >                                  |
|              |                 | > EPA needs to clarify exactly     |
|              |                 | > what taxonomic groups of         |
|              |                 | > relevance to Federally listed    |
|              |                 | > species trigger a                |
|              |                 | > species-specific refinement.     |
|              |                 | >                                  |
|              |                 | > **RESPONSE: THIS IS NOT AN ERROR |
|              |                 | > CORRECTION. THE ISSUE WILL BE    |
|              |                 | > CONSIDERED IN A SUBSEQUENT       |
|              |                 | > PHASE.**                         |
|              |                 | >                                  |
|              |                 | > Footnote:                        |
|              |                 | >                                  |
|              |                 | > 1\) The development and          |
|              |                 | > submission by FESTF of an        |
|              |                 | > Information Management System    |
|              |                 | > (IMS) that EPA can use to screen |
|              |                 | > pesticide applications when      |
|              |                 | > their applications trigger       |
|              |                 | > potential endangered species     |
|              |                 | > issues; 2) funding by the FESTF  |
|              |                 | > through a Cooperative Research   |
|              |                 | > and Development Agreement        |
|              |                 | > (CRADA) of a state by state      |
|              |                 | > species access program to be     |
|              |                 | > undertaken by EPA that will      |
|              |                 | > enable EPA to access high        |
|              |                 | > quality species locality data to |
|              |                 | > validate the IMS (replaced by    |
|              |                 | > FESTF's direct contract with     |
|              |                 | > NatureServe for EPA's access to  |
|              |                 | > these data); and 3) a quality    |
|              |                 | > test of the IMS, based in part   |
|              |                 | > upon information collected by    |
|              |                 | > EPA pursuant to the CRADA        |
|              |                 | > (NatureServe data).              |
+--------------+-----------------+------------------------------------+
| **Header**   | **pdf Version   | **Comments**                       |
|              | Page #;         |                                    |
|              | Paragraph \#**  |                                    |
+--------------+-----------------+------------------------------------+
| b\. (1)      | Page 95         | Last sentence is misleading.       |
| Discussion   |                 | Should read instead as "... level  |
| of RQ        |                 | I screening assessment show that   |
|              |                 | listed species for several taxa    |
|              |                 | are located in regions where       |
|              |                 | cypermethrin may be used based on  |
|              |                 | crop location." Misleading to      |
|              |                 | state that the RQs are above the   |
|              |                 | LOC, because this appears to       |
|              |                 | exaggerate the RQs from            |
|              |                 | terrestrial species (only a        |
|              |                 | potential "short grass" risk).     |
|              |                 |                                    |
|              |                 | **RESPONSE: AGENCY DISAGREES. THE  |
|              |                 | STATEMENT IS GENERAL AND STATES    |
|              |                 | THAT THE EXCEEDANCE OF THE LISTED  |
|              |                 | LOC SUGGESTS THAT SEVERAL LISTED   |
|              |                 | TAXA MAY BE AT RISK.**             |
+--------------+-----------------+------------------------------------+
| Probit Slope | Page 97         | It was unclear how the results of  |
| Analysis     |                 | the probit analysis were           |
|              |                 | calculated. Provide an example so  |
|              |                 | that the calculations can be       |
|              |                 | verified.                          |
|              |                 |                                    |
|              |                 | Urban and Cook 1986 is not in the  |
|              |                 | reference section. **RESPONSE:     |
|              |                 | CORRECTED**                        |
|              |                 |                                    |
|              |                 | Based on the information provided, |
|              |                 | it is not possible to determine    |
|              |                 | how the slopes, mortality          |
|              |                 | probabilities, or their respective |
|              |                 | bound estimates were calculated.   |
|              |                 | The Agency should provide the data |
|              |                 | used for this analysis to improve  |
|              |                 | the transparency of the document.  |
+--------------+-----------------+------------------------------------+
| d\. Critical | Page 98, 2^nd^  | It appears that invertebrate and   |
| Habitats     | paragraph,      | vertebrate are inverted in the     |
|              | 1^st^ sentence  | sentence.                          |
|              |                 |                                    |
|              |                 | **RESPONSE: APPENDIX GIVES AN      |
|              |                 | EXAMPLE CALCULATION FOR FRESHWATER |
|              |                 | FISH.**                            |
|              |                 |                                    |
|              |                 | The EPA should refine the risk     |
|              |                 | assessment for those groups where  |
|              |                 | potential concerns have been       |
|              |                 | identified prior to conducting any |
|              |                 | indirect effects analysis on       |
|              |                 | critical habitat. **RESPONSE: THIS |
|              |                 | RED IS A SCREENING LEVEL           |
|              |                 | ASSESSMENT**.                      |
+--------------+-----------------+------------------------------------+
| 2\.          | Page 99, 2 of   | "There are no monitoring studies   |
| Assumptions. | this section    | for cypermethrin in freshwater or  |
| for Aquatic  |                 | marine,..." Should this end with   |
| Species      |                 | "the marine environment".          |
|              |                 |                                    |
|              |                 | **RESPONSE: CORRECTED**            |
+--------------+-----------------+------------------------------------+

+--------------+---+-----------------+------------------------------------+---+
| **Header**   |   | **pdf Version   | **Comments**                       |   |
|              |   | Page #;         |                                    |   |
|              |   | Paragraph \#**  |                                    |   |
+--------------+---+-----------------+------------------------------------+---+
| Section C.   |   | Page 99         | Presumably this section is a       |   |
| Description  |   |                 | place-holder -- many obvious and   |   |
| of           |   |                 | significant assumptions and        |   |
| Assumptions, |   |                 | uncertainties are not yet          |   |
| Un           |   |                 | described.                         |   |
| certainties, |   |                 |                                    |   |
| Strengths    |   |                 | This section needs to be put into  |   |
| and          |   |                 | the context of the entire risk     |   |
| Limitations  |   |                 | characterization. For example some |   |
|              |   |                 | routes of exposure are             |   |
|              |   |                 | significantly more probable and    |   |
|              |   |                 | therefore important to the risk    |   |
|              |   |                 | characterization than others e.g., |   |
|              |   |                 | water column for aquatics and      |   |
|              |   |                 | dietary for terrestrial animals.   |   |
|              |   |                 | This should be addressed in the    |   |
|              |   |                 | Problem Formulation stage.         |   |
|              |   |                 |                                    |   |
|              |   |                 | Rather than a discussion on        |   |
|              |   |                 | endless sources of uncertainty     |   |
|              |   |                 | many of which may not be           |   |
|              |   |                 | significantly important in the     |   |
|              |   |                 | risk characterization, EFED should |   |
|              |   |                 | constructively address its plans   |   |
|              |   |                 | to refine the screening-level risk |   |
|              |   |                 | assessment presented. Refinements  |   |
|              |   |                 | to the screening-level assessment  |   |
|              |   |                 | that reduce the scope of the       |   |
|              |   |                 | effects determination for          |   |
|              |   |                 | endangered species should be a     |   |
|              |   |                 | high priority e.g., terrestrial    |   |
|              |   |                 | vertebrates.                       |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: THIS IS NOT AN ERROR   |   |
|              |   |                 | CORRECTION. THE ISSUE WILL BE      |   |
|              |   |                 | CONSIDERED IN A SUBSEQUENT         |   |
|              |   |                 | PHASE.**                           |   |
+--------------+---+-----------------+------------------------------------+---+
| **Header**   | * |                 | **Comments**                       |   |
|              | * |                 |                                    |   |
|              | p |                 |                                    |   |
|              | d |                 |                                    |   |
|              | f |                 |                                    |   |
|              | V |                 |                                    |   |
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|              | s |                 |                                    |   |
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|              | e |                 |                                    |   |
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|              | h |                 |                                    |   |
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|              | # |                 |                                    |   |
|              | * |                 |                                    |   |
|              | * |                 |                                    |   |
+--------------+---+-----------------+------------------------------------+---+
| E            | P |                 | Froelich study should be MRID      |   |
| nvironmental | a |                 | 42129003 and Curry study should be |   |
| Fate MRID    | g |                 | MRID 42129002. MRID 42868203       |   |
| Studies...   | e |                 | should be Giroir and Stuerman, not |   |
|              | 1 |                 | Sherman.                           |   |
|              | 0 |                 |                                    |   |
|              | 6 |                 | **RESPONSE: AGREE.**               |   |
+--------------+---+-----------------+------------------------------------+---+
| V.           | P |                 | Clarification on cited MRID 62793: |   |
| Literature   | a |                 |                                    |   |
| Cited.       | g |                 | MRID 62793. Edwards, P. J., Brown, |   |
| Ecological   | e |                 | S. M., and A.S. Sapiets. (February |   |
| Effects MRID | 1 |                 | 1980). Cypermethrin (PP383):       |   |
| Studies      | 0 |                 | Toxicity of technical and          |   |
| Submitted to | 8 |                 | formulated material to first       |   |
| EPA.         | . |                 | instar Daphnia magna. ICI Plant    |   |
|              |   |                 | Protection Division. RJ011OB.      |   |
|              |   |                 |                                    |   |
|              |   |                 | MRID 92027014 Hamer, M. (1990) ICI |   |
|              |   |                 | Americas Inc. Phase 3 Summary of   |   |
|              |   |                 | MRID 00062793. Cypermethrin        |   |
|              |   |                 | (PP383): Toxicity of Technical and |   |
|              |   |                 | Formulated Material to First       |   |
|              |   |                 | Instar Daphnia magna: Report No.:  |   |
|              |   |                 | RJ011OB; Study No.: PP383/CN/01.   |   |
|              |   |                 | Prepared by ICI                    |   |
|              |   |                 |                                    |   |
|              |   |                 | Agrochemicals, Jealott\'s Hill     |   |
|              |   |                 | Research Station 17 p.             |   |
|              |   |                 | **RESPONSE:CORRECTED**             |   |
+--------------+---+-----------------+------------------------------------+---+
| V.           | P |                 | Correct date for MRID 90040:       |   |
| Literature   | a |                 | delete "1972?" and replace with    |   |
| Cited.       | g |                 | "February 1979".                   |   |
| Ecological   | e |                 |                                    |   |
| Effects MRID | 1 |                 | **RESPONSE: CORRECTED**            |   |
| Studies      | 0 |                 |                                    |   |
| Submitted to | 9 |                 |                                    |   |
| EPA.         | . |                 |                                    |   |
+--------------+---+-----------------+------------------------------------+---+
| Appendix A   | P |                 | Aqueous Photolysis value is 30.1   |   |
|              | a |                 | days.                              |   |
| 161-2        | g |                 |                                    |   |
| Aqueous      | e |                 | Reference: Laskowski, D. 2002.     |   |
| Photolysis   | A |                 | Reviews of Environmental           |   |
|              | - |                 | Contamination and Toxicity. Volume |   |
|              | 1 |                 | 174. pp 52.                        |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: THIS ISSUE WAS         |   |
|              |   |                 | PREVIOUSLY ADDRESSED.**            |   |
+--------------+---+-----------------+------------------------------------+---+
| Appendix A   | P |                 | Soil Photolysis value is 165 days. |   |
|              | a |                 |                                    |   |
| 161-3 Soil   | g |                 | Reference: Laskowski, D. 2002.     |   |
| Photolysis   | e |                 | Reviews of Environmental           |   |
|              | A |                 | Contamination and Toxicity. Volume |   |
|              | - |                 | 174. pp 52.                        |   |
|              | 1 |                 |                                    |   |
|              |   |                 | **RESPONSE: THIS ISSUE WAS         |   |
|              |   |                 | PREVIOUSLY ADDRESSED.**            |   |
+--------------+---+-----------------+------------------------------------+---+
| Appendix A   | P |                 | Aerobic Soil Metabolism value is   |   |
|              | a |                 | 39.2 days \[mean + confidence      |   |
| 162-1        | g |                 | limit (CL)\].                      |   |
| Aerobic Soil | e |                 |                                    |   |
| Metabolism   | A |                 | Reference: Laskowski, D. 2002.     |   |
|              | - |                 | Reviews of Environmental           |   |
|              | 2 |                 | Contamination and Toxicity. Volume |   |
|              |   |                 | 174. pp 92                         |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: THIS ISSUE WAS         |   |
|              |   |                 | PREVIOUSLY ADDRESSED.**            |   |
+--------------+---+-----------------+------------------------------------+---+
| Appendix A   | P |                 | Anaerobic Soil Metabolism value is |   |
|              | a |                 | 165 days \[mean + CL\].            |   |
| 162-2        | g |                 |                                    |   |
| Anaerobic    | e |                 | Reference: Laskowski, D. 2002.     |   |
| Soil         | A |                 | Reviews of Environmental           |   |
| Metabolism   | - |                 | Contamination and Toxicity. Volume |   |
|              | 2 |                 | 174. pp 93.                        |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: THIS ISSUE WAS         |   |
|              |   |                 | PREVIOUSLY ADDRESSED.**            |   |
+--------------+---+-----------------+------------------------------------+---+
| **Header**   | * |                 | **Comments**                       |   |
|              | * |                 |                                    |   |
|              | p |                 |                                    |   |
|              | d |                 |                                    |   |
|              | f |                 |                                    |   |
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|              | P |                 |                                    |   |
|              | a |                 |                                    |   |
|              | g |                 |                                    |   |
|              | e |                 |                                    |   |
|              | # |                 |                                    |   |
|              | ; |                 |                                    |   |
|              | P |                 |                                    |   |
|              | a |                 |                                    |   |
|              | r |                 |                                    |   |
|              | a |                 |                                    |   |
|              | g |                 |                                    |   |
|              | r |                 |                                    |   |
|              | a |                 |                                    |   |
|              | p |                 |                                    |   |
|              | h |                 |                                    |   |
|              | \ |                 |                                    |   |
|              | # |                 |                                    |   |
|              | * |                 |                                    |   |
|              | * |                 |                                    |   |
+--------------+---+-----------------+------------------------------------+---+
| Appendix A   | P |                 | Aerobic Aquatic Metabolism value   |   |
|              | a |                 | is 10.6 days \[mean + CL\].        |   |
| 162-4        | g |                 |                                    |   |
| Aerobic      | e |                 | Reference: Laskowski, D. 2002.     |   |
| Aquatic      | A |                 | Reviews of Environmental           |   |
| Metabolism   | - |                 | Contamination and Toxicity. Volume |   |
|              | 3 |                 | 174. pp 94.                        |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: THIS ISSUE WAS         |   |
|              |   |                 | PREVIOUSLY ADDRESSED.**            |   |
+--------------+---+-----------------+------------------------------------+---+
| Appendix A   | P |                 | Anaerobic Aquatic Metabolism value |   |
|              | a |                 | is 22.2 days \[mean + CL\].        |   |
| 162-3        | g |                 |                                    |   |
| Anaerobic    | e |                 | Reference: Laskowski, D. 2002.     |   |
| Aquatic      | A |                 | Reviews of Environmental           |   |
| Metabolism   | - |                 | Contamination and Toxicity. Volume |   |
|              | 3 |                 | 174. pp 95.                        |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: THIS ISSUE WAS         |   |
|              |   |                 | PREVIOUSLY ADDRESSED.**            |   |
+--------------+---+-----------------+------------------------------------+---+
| **Header**   | * |                 | **Comments**                       |   |
|              | * |                 |                                    |   |
|              | p |                 |                                    |   |
|              | d |                 |                                    |   |
|              | f |                 |                                    |   |
|              | V |                 |                                    |   |
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|              | i |                 |                                    |   |
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|              | g |                 |                                    |   |
|              | e |                 |                                    |   |
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|              | P |                 |                                    |   |
|              | a |                 |                                    |   |
|              | r |                 |                                    |   |
|              | a |                 |                                    |   |
|              | g |                 |                                    |   |
|              | r |                 |                                    |   |
|              | a |                 |                                    |   |
|              | p |                 |                                    |   |
|              | h |                 |                                    |   |
|              | \ |                 |                                    |   |
|              | # |                 |                                    |   |
|              | * |                 |                                    |   |
|              | * |                 |                                    |   |
+--------------+---+-----------------+------------------------------------+---+
| Appendix A   | P |                 | The K~oc~ value is 310,000.        |   |
|              | a |                 |                                    |   |
| 163-1        | g |                 | Reference: Laskowski, D. 2002.     |   |
| Mobility --  | e |                 | Reviews of Environmental           |   |
| Leaching and | A |                 | Contamination and Toxicity. Volume |   |
| Ad/Des       | - |                 | 174. pp 52.                        |   |
|              | 4 |                 |                                    |   |
|              |   |                 | **RESPONSE: THIS ISSUE WAS         |   |
|              |   |                 | PREVIOUSLY ADDRESSED.**            |   |
+--------------+---+-----------------+------------------------------------+---+
| Appendix A   | P |                 | Aerobic Aq, Anaerobic Aq           |   |
|              | a |                 | Metabolism and Aq Field            |   |
|              | g |                 | Dissipation studies support a      |   |
|              | e |                 | zeta-cypermethrin rice             |   |
|              | s |                 | registration. These studies are    |   |
|              | A |                 | not relevant for cypermethrin.     |   |
|              | 1 |                 |                                    |   |
|              | - |                 | **RESPONSE: THIS IS NOT AN ERROR   |   |
|              | A |                 | CORRECTION. THE ISSUE WILL BE      |   |
|              | 7 |                 | CONSIDERED IN A SUBSEQUENT PHASE** |   |
+--------------+---+-----------------+------------------------------------+---+
|              | P |                 | Page is blank.                     |   |
|              | a |                 |                                    |   |
|              | g |                 | **RESPONSE: THIS ISSUE WAS         |   |
|              | e |                 | PREVIOUSLY ADDRESSED.**            |   |
|              | A |                 |                                    |   |
|              | 1 |                 |                                    |   |
|              | 5 |                 |                                    |   |
|              | . |                 |                                    |   |
+--------------+---+-----------------+------------------------------------+---+
| Appendix A   | P |                 | The bioconcentration factor based  |   |
|              | a |                 | on fish whole-body analysis is     |   |
| 165-4        | g |                 | 597.                               |   |
| Bio          | e |                 |                                    |   |
| accumulation | A |                 | Reference: Laskowski, D. 2002.     |   |
| in Fish      | - |                 | Reviews of Environmental           |   |
|              | 8 |                 | Contamination and Toxicity. Volume |   |
|              |   |                 | 174. pp 52 & 85.                   |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: THIS ISSUE WAS         |   |
|              |   |                 | PREVIOUSLY ADDRESSED.**            |   |
+--------------+---+-----------------+------------------------------------+---+
| Appendix B   | P |                 | The use of the 1- in- 10 year      |   |
|              | a |                 | probability is a very conservative |   |
| 1\. 1 -- in- | g |                 | and protective methodology.        |   |
| 10 year      | e |                 | However, it is most appropriate to |   |
| Probability  | B |                 | chose the 1 -- in- 10 year         |   |
|              | - |                 | distributional value that          |   |
|              | 1 |                 | corresponds to the toxicology end  |   |
|              |   |                 | point study length, i.e. 96-hour,  |   |
|              |   |                 | 21-day, etc. as opposed to the     |   |
|              |   |                 | peak value.                        |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: The Agency does point  |   |
|              |   |                 | estimates in the Tier I Risk       |   |
|              |   |                 | Assessment. We also use the        |   |
|              |   |                 | concentration corresponding to the |   |
|              |   |                 | particular endpoint of concern     |   |
|              |   |                 | (e.g. peak for acute, 21 day for   |   |
|              |   |                 | invertebrate chronic, and 65-days  |   |
|              |   |                 | for fish chronic. The use of peak  |   |
|              |   |                 | values is more protective. This is |   |
|              |   |                 | a policy issue, not an error.**    |   |
+--------------+---+-----------------+------------------------------------+---+
|              | P |                 | Helsel and Hirsch 1993 reference   |   |
|              | a |                 | missing from any reference list.   |   |
|              | g |                 |                                    |   |
|              | e |                 | **RESPONSE: REFERENCE WAS ADDED.** |   |
|              | B |                 |                                    |   |
|              | 1 |                 |                                    |   |
+--------------+---+-----------------+------------------------------------+---+
|              | P |                 | Page is blank.                     |   |
|              | a |                 |                                    |   |
|              | g |                 | **RESPONSE: THIS ISSUE WAS         |   |
|              | e |                 | PREVIOUSLY ADDRESSED.**            |   |
|              | C |                 |                                    |   |
|              | 2 |                 |                                    |   |
|              | . |                 |                                    |   |
+--------------+---+-----------------+------------------------------------+---+
| Appendix B   | P |                 | Please use the appropriate e-fate  |   |
|              | a |                 | inputs as corrected by registrants |   |
| 2\.          | g |                 | in Appendix A for all modeling     |   |
| PRZM/EXAMS   | e |                 | runs.                              |   |
| Modeling     | s |                 |                                    |   |
| Results      | B |                 | **RESPONSE: THIS ISSUE WAS         |   |
|              | - |                 | PREVIOUSLY ADDRESSED.**            |   |
|              | 2 |                 |                                    |   |
|              | t |                 |                                    |   |
|              | h |                 |                                    |   |
|              | r |                 |                                    |   |
|              | o |                 |                                    |   |
|              | u |                 |                                    |   |
|              | g |                 |                                    |   |
|              | h |                 |                                    |   |
|              | B |                 |                                    |   |
|              | - |                 |                                    |   |
|              | 5 |                 |                                    |   |
|              | 1 |                 |                                    |   |
+--------------+---+-----------------+------------------------------------+---+
| Appendix D   | P |                 | [Please provide the attached       | [ |
|              | a |                 | Microsoft Excel spreadsheets as    | ] |
| T-REX Model  | g |                 | indicated in the IRED.]{.mark}     | { |
| Inputs,      | e |                 |                                    | . |
| Results,     | D |                 | [•                                 | m |
| Output       | - |                 | Cypermeth                          | a |
|              | 1 |                 | rin_T-REX_cotton_v1.12.xls]{.mark} | r |
|              |   |                 |                                    | k |
|              |   |                 | [•                                 | } |
|              |   |                 | Cypermethr                         |   |
|              |   |                 | in_T-REX_lettuce_v1.12.xls]{.mark} |   |
|              |   |                 |                                    |   |
|              |   |                 | [•                                 |   |
|              |   |                 | Cypermeth                          |   |
|              |   |                 | rin_T-REX_pecans_v1.12.xls]{.mark} |   |
|              |   |                 |                                    |   |
|              |   |                 | []{.mark}                          |   |
|              |   |                 |                                    |   |
|              |   |                 | [Rape is not registered -remove    |   |
|              |   |                 | Cypermethrin_T-REX_rape_v1.12.xls  |   |
|              |   |                 | --]{.mark}                         |   |
+--------------+---+-----------------+------------------------------------+---+
|              | P |                 | [Please add the T-REX model to the | [ |
|              | a |                 | reference list.]{.mark}            | ] |
|              | g |                 |                                    | { |
|              | e |                 |                                    | . |
|              | D |                 |                                    | m |
|              | - |                 |                                    | a |
|              | 4 |                 |                                    | r |
|              |   |                 |                                    | k |
|              |   |                 |                                    | } |
+--------------+---+-----------------+------------------------------------+---+
|              | P |                 | 1^st^ paragraph -- provide the     |   |
|              | a |                 | graphs.                            |   |
|              | g |                 |                                    |   |
|              | e |                 |                                    |   |
|              | D |                 |                                    |   |
|              | - |                 |                                    |   |
|              | 4 |                 |                                    |   |
+--------------+---+-----------------+------------------------------------+---+
| **Header**   |   | **pdf Version   | **Comments**                       |   |
|              |   | Page #;         |                                    |   |
|              |   | Paragraph \#**  |                                    |   |
+--------------+---+-----------------+------------------------------------+---+
| Appendix E   |   | Page E-3, 1^st^ | \% ai for GFU 061 is 36%. Update   |   |
| Ecological   |   | full paragraph, | the (% ai not reported) in the     |   |
| Effects      |   | 2^nd^ line      | text to reflect this change.       |   |
| Database     |   |                 |                                    |   |
|              |   |                 | **RESPONSE: CORRECTED**            |   |
+--------------+---+-----------------+------------------------------------+---+
|              |   | Page E-3-,      | The sentence appears to be         |   |
|              |   | 1^st^ full      | incomplete. Also, formations       |   |
|              |   | paragraph,      | should be formulations.            |   |
|              |   | 5^th^           |                                    |   |
|              |   | sent            | **RESPONSE: CORRECTED**            |   |
|              |   | ence\-\--"Based |                                    |   |
|              |   | on these        |                                    |   |
|              |   | results....     |                                    |   |
+--------------+---+-----------------+------------------------------------+---+
|              |   | Page E8         | MRID 44546027 is a                 |   |
|              |   |                 | beta-cypermethrin.                 |   |
|              |   |                 | beta-Cypermethrin studies should   |   |
|              |   |                 | not be used in estimating          |   |
|              |   |                 | cypermethrin risk.                 |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: DISCUSSED PREVIOUSLY** |   |
+--------------+---+-----------------+------------------------------------+---+
|              |   | Page E-14,      | The sentence appears to be         |   |
|              |   | 1^st^ full      | incomplete. Also, formations       |   |
|              |   | sentence        | should be formulations.            |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: CORRECTED**            |   |
+--------------+---+-----------------+------------------------------------+---+
|              |   | Page E-27.      | "???" in percent a.i. column:      |   |
|              |   |                 | Radio-labeled technical, therefore |   |
|              |   |                 | \"???\" should read \"Technical\". |   |
|              |   |                 | **RESPONSE: CORRECTED**            |   |
+--------------+---+-----------------+------------------------------------+---+
|              |   | Page E16        | MRID 44546031 is a                 |   |
|              |   |                 | beta-cypermethrin study.           |   |
|              |   |                 | beta-Cypermethrin studies should   |   |
|              |   |                 | not be used in estimating          |   |
|              |   |                 | cypermethrin risk.                 |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: PREVIOUSLY             |   |
|              |   |                 | DISCUSSED.**                       |   |
+--------------+---+-----------------+------------------------------------+---+
|              |   | Page E-31, line | 4.3 ug ai/L should be 3.42 ug ai/L |   |
|              |   | 6 of 1st        |                                    |   |
|              |   | paragraph       | **RESPONSE: CORRECTED**            |   |
+--------------+---+-----------------+------------------------------------+---+
|              |   | Page E-31       | MRID is 41068003 not 41968212.     |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: CORRECTED**            |   |
+--------------+---+-----------------+------------------------------------+---+
|              |   | Page E-39       | Table E-6, MRID 070562 mysid       |   |
|              |   |                 | shrimp, the 24 hr LC50 is = 44.7   |   |
|              |   |                 | pptr not \> 24 pptr                |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: CORRECTED**            |   |
+--------------+---+-----------------+------------------------------------+---+
|              |   | Page E-39-40    | MRID 44561209 - beta-cypermethrin  |   |
|              |   |                 | studies should not be used in      |   |
|              |   |                 | estimating cypermethrin risk.      |   |
|              |   |                 | **RESPONSE: PREVIOUSLY             |   |
|              |   |                 | DISCUSSED.**                       |   |
+--------------+---+-----------------+------------------------------------+---+
|              |   | Page E41        | Table E7, study MRID 070562,       |   |
|              |   |                 | chronic mysid shrimp, the MATC is  |   |
|              |   |                 | greater than 0.44 ng/L but less    |   |
|              |   |                 | than 0.64 ng/L. This is not        |   |
|              |   |                 | captured within the table          |   |
|              |   |                 | descriptions.                      |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: CORRECTED**            |   |
+--------------+---+-----------------+------------------------------------+---+
|              |   | Page E44        | MRID 44546035 is a                 |   |
|              |   |                 | beta-cypermethrin study.           |   |
|              |   |                 | beta-Cypermethrin studies should   |   |
|              |   |                 | not be used in estimating          |   |
|              |   |                 | cypermethrin risk. **RESPONSE:     |   |
|              |   |                 | PREVIOUSLY DISCUSSED**             |   |
+--------------+---+-----------------+------------------------------------+---+
|              |   | Page E56.       | Page is blank.                     |   |
+--------------+---+-----------------+------------------------------------+---+
|              |   | Page E57        | Endpoints need correcting -- LD50  |   |
|              |   |                 | male is \> 10,248 not \> 9520 mg   |   |
|              |   |                 | ai/kg bw; female LD50 is \> 12,085 |   |
|              |   |                 | not \> 11, 227 mg ai/kg bw.        |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: CORRECTED**            |   |
+--------------+---+-----------------+------------------------------------+---+
|              |   | Page E57-58     | MRID 44546024 is a                 |   |
|              |   |                 | beta-cypermethrin study.           |   |
|              |   |                 | Beta-Cypermethrin studies should   |   |
|              |   |                 | not be used in estimating          |   |
|              |   |                 | cypermethrin risk.                 |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: PREVIOUSLY DISCUSSED** |   |
+--------------+---+-----------------+------------------------------------+---+
| **Header**   |   | **pdf Version   | **Comments**                       |   |
|              |   | Page #;         |                                    |   |
|              |   | Paragraph \#**  |                                    |   |
+--------------+---+-----------------+------------------------------------+---+
| Appendix E   |   | Page E-58,      | MRID 445460261- should read MRID   |   |
| Ecological   |   | paragraph below | 44546026                           |   |
| Effects      |   | table, 7^th^    |                                    |   |
| Database     |   | sentence        | **RESPONSE: CORRECTED**            |   |
+--------------+---+-----------------+------------------------------------+---+
|              |   | Page E59        | Acute dietary avian studies, MRID  |   |
|              |   |                 | 90071 and 90072, LC50 is \> 20,000 |   |
|              |   |                 | ppm for both not \> 2,634 ppm and  |   |
|              |   |                 | \> 3,951 ppm.                      |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: CORRECTED**            |   |
+--------------+---+-----------------+------------------------------------+---+
|              |   |                 | MRID 90071 and 90072 toxic         |   |
|              |   |                 | category ids "practically          |   |
|              |   |                 | non-toxic" not "slightly toxic".   |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: CORRECTED**            |   |
+--------------+---+-----------------+------------------------------------+---+
|              |   | Page E60        | Remove referenced                  |   |
|              |   |                 | beta-cypermethrin studies from the |   |
|              |   |                 | list (MRID 44546025 and MRID       |   |
|              |   |                 | 44546026).                         |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: BETA CYPERMETHRIN      |   |
|              |   |                 | INFORMATION WAS USED AS BRIDGING   |   |
|              |   |                 | DATA. TOXICITY IS IN THE SAME**    |   |
+--------------+---+-----------------+------------------------------------+---+
|              |   | Page E65        | MRID 44544208 studies are          |   |
|              |   |                 | beta-cypermethrin studies.         |   |
|              |   |                 | Beta-Cypermethrin studies should   |   |
|              |   |                 | not be used in estimating          |   |
|              |   |                 | cypermethrin risk. **RESPONSE:     |   |
|              |   |                 | BETA CYPERMETHRIN INFORMATION WAS  |   |
|              |   |                 | USED AS BRIDGING DATA. TOXICITY IS |   |
|              |   |                 | IN THE SAME**                      |   |
+--------------+---+-----------------+------------------------------------+---+
|              |   | Page E66        | Two studies listed, the purity is  |   |
|              |   |                 | 36.8% not 37.2%.                   |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: CORRECTED**            |   |
+--------------+---+-----------------+------------------------------------+---+
| Appendix F   |   | Page F-1        | The RQ equation is superimposed on |   |
|              |   |                 | the text in both the electronic    |   |
| The Risk     |   |                 | and paper copies.                  |   |
| Quotien      |   |                 |                                    |   |
| t...Concerns |   |                 | **RESPONSE: CORRECTED**            |   |
+--------------+---+-----------------+------------------------------------+---+
| Appendix G   |   | Page G-3        | The 21-day EEC for TX cotton is    |   |
|              |   |                 | 0.060 ug/L, which also changes the |   |
| Table G-4    |   |                 | chronic RQ to 0.9, below the LOC.  |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: CORRECTED**            |   |
+--------------+---+-----------------+------------------------------------+---+
| Appendix G   |   | Page G-5        | The 21-day EEC for TX cotton is    |   |
|              |   |                 | 0.060 ug/L.                        |   |
| Table G-6    |   |                 |                                    |   |
|              |   |                 | **RESPONSE: CORRECTED**            |   |
+--------------+---+-----------------+------------------------------------+---+
| Appendix G   |   | Page G-7        | The peak EEC for CA lettuce is     |   |
|              |   |                 | 30.5 ug/kg.                        |   |
| Table G-9    |   |                 |                                    |   |
|              |   |                 | **RESPONSE: CORRECTED**            |   |
+--------------+---+-----------------+------------------------------------+---+
| Appendix G   |   | Page G-8        | The peak EEC for TX cotton is      |   |
|              |   |                 | 0.0073 ug/L.                       |   |
| Table G-10   |   |                 |                                    |   |
|              |   |                 | **RESPONSE: CORRECTED**            |   |
+--------------+---+-----------------+------------------------------------+---+
| Appendix G   |   | Page G-9        | The page is blank.                 |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: THIS ISSUE WAS         |   |
|              |   |                 | PREVIOUSLY ADDRESSED.**            |   |
+--------------+---+-----------------+------------------------------------+---+
| Appendix G   |   | Pages G-12 to   | The T-REX output was not included  |   |
|              |   | G-20            | in Appendix D, so the RQs could    |   |
| Tables G-13  |   |                 | not be checked.                    |   |
| to           |   |                 |                                    |   |
|              |   |                 |                                    |   |
| G-24         |   |                 |                                    |   |
+--------------+---+-----------------+------------------------------------+---+
| Appendix H   |   | Page H1         | Please provide an anticipated      |   |
|              |   |                 | timeline for the ES assessment (if |   |
|              |   |                 | available).                        |   |
|              |   |                 |                                    |   |
|              |   |                 | **Response: The Agency will not be |   |
|              |   |                 | providing a list of species        |   |
|              |   |                 | relative to use sites, at this     |   |
|              |   |                 | time.**                            |   |
+--------------+---+-----------------+------------------------------------+---+
|              |   | Page H2.        | Page is blank.                     |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: THIS ISSUE WAS         |   |
|              |   |                 | PREVIOUSLY ADDRESSED.**            |   |
+--------------+---+-----------------+------------------------------------+---+
| **Header**   |   | **pdf Version   | **Comments**                       |   |
|              |   | Page #;         |                                    |   |
|              |   | Paragraph \#**  |                                    |   |
+--------------+---+-----------------+------------------------------------+---+
| Appendix I   |   | Table I-1, Page | -   161-1 Aqueous Photolysis value |   |
|              |   | I-1             |     is 30.1 days.                  |   |
| Data         |   |                 |                                    |   |
| Requirement  |   |                 | -   161-3 Soil Photolysis value is |   |
| Tables --    |   |                 |     165 days.                      |   |
| E            |   |                 |                                    |   |
| nvironmental |   |                 | -   162-1 Aerobic Soil Metabolism  |   |
| Fate and     |   |                 |     value is 39.2 days \[mean +    |   |
| Effects      |   |                 |     confidence limit (CL)\].       |   |
|              |   |                 |                                    |   |
|              |   |                 | -   162-2 Anaerobic Soil           |   |
|              |   |                 |     Metabolism value is 165 days   |   |
|              |   |                 |     \[mean + CL\].                 |   |
|              |   |                 |                                    |   |
|              |   |                 | -   162-4 Aerobic Aquatic          |   |
|              |   |                 |     Metabolism value is 10.6 days  |   |
|              |   |                 |     \[mean + CL\].                 |   |
|              |   |                 |                                    |   |
|              |   |                 | -   162-3 Anaerobic Aquatic        |   |
|              |   |                 |     Metabolism value is 22.2 days  |   |
|              |   |                 |     \[mean + CL\].                 |   |
|              |   |                 |                                    |   |
|              |   |                 | -   163-1 The K~oc~ value is       |   |
|              |   |                 |     310,000.                       |   |
|              |   |                 |                                    |   |
|              |   |                 | -   165-4 The bioconcentration     |   |
|              |   |                 |     factor based on fish           |   |
|              |   |                 |     whole-body analysis is 597.    |   |
|              |   |                 |                                    |   |
|              |   |                 | Reference: Laskowski, D. 2002.     |   |
|              |   |                 | Reviews of Environmental           |   |
|              |   |                 | Contamination and Toxicity. Volume |   |
|              |   |                 | 174.                               |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: THIS ISSUE WAS         |   |
|              |   |                 | PREVIOUSLY ADDRESSED.**            |   |
|              |   |                 |                                    |   |
|              |   |                 | MRID 4212[4]{.underline}002- is a  |   |
|              |   |                 | typo 4212[9]{.underline}002        |   |
|              |   |                 | (ad/des)                           |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: AGREE.**               |   |
+--------------+---+-----------------+------------------------------------+---+
|              |   | Pages I3, I5,   | It is unclear why one entry is     |   |
|              |   | I6              | highlighted in blue.               |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: CORRECTED**            |   |
+--------------+---+-----------------+------------------------------------+---+
| Appendix I   |   | Page I5,        | It is unclear why one entry is     |   |
|              |   | 72-3(d)         | highlighted in blue.               |   |
| Data         |   |                 |                                    |   |
| Requirement  |   |                 | **RESPONSE: CORRECTED**            |   |
| Tables       |   |                 |                                    |   |
| (Ecological  |   |                 |                                    |   |
| Effects)     |   |                 |                                    |   |
+--------------+---+-----------------+------------------------------------+---+
|              |   | Page I5         | 72-4, MRID 89047 is a 21-day       |   |
|              |   |                 | daphnia magna not a marine study   |   |
|              |   |                 | but freshwater study.              |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: CORRECTED**            |   |
+--------------+---+-----------------+------------------------------------+---+
|              |   | Page I6, 72-7   | It is unclear why one entry is     |   |
|              |   |                 | highlighted in blue.               |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: CORRECTED**            |   |
+--------------+---+-----------------+------------------------------------+---+
| Appendix J   |   | Page J-1        | Certainty Index, remove zeros      |   |
|              |   |                 | after the decimal.                 |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: CORRECTED**            |   |
+--------------+---+-----------------+------------------------------------+---+
|              |   | Page J-1        | J1 (J2?); the Certainty Index do   |   |
|              |   |                 | not match those listed on p-93     |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: CORRECTED**            |   |
+--------------+---+-----------------+------------------------------------+---+
| Appendix K   |   | Page K-1        | [Provide Excel files -- they are   |   |
|              |   |                 | not attached.]{.mark}              |   |
|              |   |                 |                                    |   |
|              |   |                 | [Which 10 publications? Provide    |   |
|              |   |                 | list.]{.mark}                      |   |
+--------------+---+-----------------+------------------------------------+---+
| **Header**   |   | **pdf Version   | **Comments**                       |   |
|              |   | Page #;         |                                    |   |
|              |   | Paragraph \#**  |                                    |   |
+--------------+---+-----------------+------------------------------------+---+
| Appendix L   |   | Pages L-1       | Numbers are very difficult to read |   |
|              |   | through L-8     | on both electronic and paper       |   |
| Use          |   |                 | copies.                            |   |
| Char         |   |                 |                                    |   |
| acterization |   |                 | **RESPONSE: THIS ISSUE WAS         |   |
| Maps         |   |                 | PREVIOUSLY ADDRESSED.**            |   |
+--------------+---+-----------------+------------------------------------+---+
|              |   | Page L-2        | Page is unreadable. Map is cutoff  |   |
|              |   |                 | and text is overlapping on both    |   |
|              |   |                 | electronic and paper copies.       |   |
+--------------+---+-----------------+------------------------------------+---+
|              |   | Pages L-4 and   | Pages are blank.                   |   |
|              |   | L-6.            |                                    |   |
|              |   |                 | **RESPONSE: THIS ISSUE WAS         |   |
|              |   |                 | PREVIOUSLY ADDRESSED.**            |   |
+--------------+---+-----------------+------------------------------------+---+
|              |   | Page L-8        | Text is overlapping base map on    |   |
|              |   |                 | both electronic and paper copies.  |   |
|              |   |                 |                                    |   |
|              |   |                 | Figure 6 and figure 7 embedded on  |   |
|              |   |                 | each other. One of the figures is  |   |
|              |   |                 | missing.                           |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: CORRECTED**            |   |
+--------------+---+-----------------+------------------------------------+---+
| Appendix M   |   | Page M- 1       | Please define benthos (as the      |   |
| Equilibrium  |   |                 | bottom of a pond) for the general  |   |
| Partitioning |   |                 | public.                            |   |
| and          |   |                 |                                    |   |
| C            |   |                 | **RESPONSE: CORRECTED**            |   |
| oncentration |   |                 |                                    |   |
| in the       |   |                 |                                    |   |
| Sediment     |   |                 |                                    |   |
+--------------+---+-----------------+------------------------------------+---+
|              |   | Page M-3        | Cannot find Table 3.7 in this      |   |
|              |   |                 | document. This reference should be |   |
|              |   |                 | Tables 7-9 (pages 42-44).          |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: CORRECTED**            |   |
+--------------+---+-----------------+------------------------------------+---+
|              |   | Page M-3        | The range of EECs in benthic pore  |   |
|              |   |                 | water by PRZM/EXAMS is 0.0044 -    |   |
|              |   |                 | 0.0304 ug/L. The highest EECs are  |   |
|              |   |                 | for the NC Cotton scenario.        |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: CORRECTED**            |   |
+--------------+---+-----------------+------------------------------------+---+
| Appendix N.  |   | Page M-4        | There are two appendices titled    |   |
| E            |   |                 | Appendix N. The Environmental Fate |   |
| nvironmental |   |                 | bibliography is on pages M-4 to    |   |
| Fate and     |   |                 | M-7 in the second Appendix N.      |   |
| Monitoring   |   |                 | Rename appendices and renumber     |   |
| Bibliography |   |                 | pages as appropriate.              |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: CORRECTED.**           |   |
+--------------+---+-----------------+------------------------------------+---+
|              |   | Page M-6        | For MRID 42868203, the authors are |   |
|              |   |                 | E. Giroir and L. Stuerman, not L.  |   |
|              |   |                 | Sherman.                           |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: AGREE, CORRECTED.**    |   |
+--------------+---+-----------------+------------------------------------+---+
|              |   | Page M-6        | For MRID 44876105, the author is   |   |
|              |   |                 | A. Ramsey and the report date is   |   |
|              |   |                 | 1998. For clarity, the Lab study   |   |
|              |   |                 | number is 194E2697E1, and the      |   |
|              |   |                 | report number is P-3329.           |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: THE STUDY AUTHOR WAS   |   |
|              |   |                 | CORRECTED.**                       |   |
+--------------+---+-----------------+------------------------------------+---+
| Appendix N.  |   | Page N 1        | Reference Accession No. 070562:    |   |
| Ecological   |   |                 | Replace with full reference:       |   |
| Effects MRID |   |                 |                                    |   |
| Studies      |   |                 | "Stephenson, R.R.; Sherwood, C.M.; |   |
| Submitted to |   |                 | Bennett, D.; et al. (1980) The     |   |
| EPA          |   |                 | Acute Toxicity of WL 43467 to Some |   |
|              |   |                 | Freshwater Invertebrates in Static |   |
|              |   |                 | Water Tests: Group Research Report |   |
|              |   |                 | TLGR.80.040. (Un‑published study   |   |
|              |   |                 | received Dec 30, 1981 under        |   |
|              |   |                 | 10182‑64; prepared by Shell        |   |
|              |   |                 | Research, Ltd., England, submitted |   |
|              |   |                 | by ICI Americas, Inc., Wilmington, |   |
|              |   |                 | Del.; CDL:070562‑F)".              |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: CORRECTED**            |   |
+--------------+---+-----------------+------------------------------------+---+
|              |   | Page N 2        | Clarify MRID 62793 as follows:     |   |
|              |   |                 |                                    |   |
|              |   |                 | MRID 62793. Edwards, P. J., Brown, |   |
|              |   |                 | S. M., and A.S. Sapiets. (February |   |
|              |   |                 | 1980). Cypermethrin (PP383):       |   |
|              |   |                 | Toxicity of technical and          |   |
|              |   |                 | formulated material to first       |   |
|              |   |                 | instar Daphnia magna. ICI Plant    |   |
|              |   |                 | Protection Division. RJ011OB.      |   |
|              |   |                 |                                    |   |
|              |   |                 | MRID 92027014 Hamer, M. (1990) ICI |   |
|              |   |                 | Americas Inc. Phase 3 Summary of   |   |
|              |   |                 | MRID 00062793. Cypermethrin        |   |
|              |   |                 | (PP383): Toxicity of Technical and |   |
|              |   |                 |                                    |   |
|              |   |                 | Formulated Material to First       |   |
|              |   |                 | Instar Daphnia magna: Report No.:  |   |
|              |   |                 | RJ011OB; Study No.: PP383/CN/01.   |   |
|              |   |                 | Prepared by ICI Agrochemicals,     |   |
|              |   |                 | Jealott\'s Hill Research Station   |   |
|              |   |                 | 17 p.                              |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: CORRECTED**            |   |
+--------------+---+-----------------+------------------------------------+---+
|              |   | Page N 3        | Correct MRID 65812 as follows:     |   |
|              |   |                 |                                    |   |
|              |   |                 | Delete author ICI and replace with |   |
|              |   |                 | \"Hill, R. W.\".; insert report    |   |
|              |   |                 | number "ICI Brixham BL/B/2011".    |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: CORRECTED**            |   |
+--------------+---+-----------------+------------------------------------+---+
|              |   | Page N 5        | Correct date for MRID 90040:       |   |
|              |   |                 | delete "1972?" and replace with    |   |
|              |   |                 | "February 1979".                   |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: CORRECTED**            |   |
+--------------+---+-----------------+------------------------------------+---+
|              |   | Pages N 10      | References for beta-cypermethrin   |   |
|              |   | --N11           | are listed. beta-Cypermethrin      |   |
|              |   |                 | studies should not be used in      |   |
|              |   |                 | estimating cypermethrin risk.      |   |
|              |   |                 |                                    |   |
|              |   |                 | **RESPONSE: BETA CYPERMETHRIN      |   |
|              |   |                 | INFORMATION WAS USED AS BRIDGING   |   |
|              |   |                 | DATA. TOXICITY IS IN THE SAME**    |   |
+--------------+---+-----------------+------------------------------------+---+

**Valent BioScience Error Correction Comments:**

![](media/image2.jpeg){width="6.492361111111111in"
height="6.749305555555556in"}

**EFED Responses:**

xii; xvi; 45; 1^st^ paragraph; 46, 3^rd^ paragraph, last sentence; A-11
thru A-14; A-15; G-9; H-2; L-2; L-4, L-6; L-8 - Responses to these items
were provided earlier in this report (refer to comments and responses
above).

47, Footnote - Font in the footnote is different -- this comment is not
an error.

86 thru remaining text -- It was found that the same font and font size
were used, the difference was the line height. This minor problem was
resolved.

95, Table 20 -- Table was corrected.

E-20 --

H-1 --

M-4; M-4 thru M-7; N-1; N-7 to N-8, N-9 to N-10; O-1 -- Various comments
-- All these problems were corrected. The EFED will try to avoid
confusion with the printouts of the maps. The numbering of the
appendices was corrected.

[^1]: