> Updated March 25, 2004

**CURRICULUM VITAE**

Name: Susanne M. Gollin, Ph.D.

Business Address: Department of Human Genetics

University of Pittsburgh

Graduate School of Public Health

130 DeSoto Street

Pittsburgh, PA 15261

Business Telephone: (412) 624‑5390

EDUCATION AND TRAINING

Undergraduate: Northwestern University

Evanston, Illinois

Graduate: Northwestern University

Evanston, Illinois

Postgraduate: Postdoctoral Fellow in Genetics (Pediatrics)

> University of Rochester School of Medicine and Dentistry
>
> Rochester, NY

Postdoctoral Research Associate in Cell Biology

> Baylor College of Medicine
>
> Houston, Texas

Postdoctoral Research Associate, Kleberg Cytogenetics Laboratory

> Baylor College of Medicine
>
> Houston, Texas
>
> Exchange scientist, Molecular Tumor Virology
>
> Deutsches Krebsforschungszentrum
>
> Heidelberg, Germany

APPOINTMENTS AND POSITIONS

> Member, University of Pittsburgh Cancer Institute
>
> Director of Research and Clinical Cytogenetics Consultant
>
> The Pittsburgh Cytogenetics Laboratory
>
> University of Pittsburgh Medical Center
>
> Professor of Human Genetics (with tenure) and Associate Professor of
> Otolaryngology and Pathology, University of Pittsburgh Graduate School
> of Public Health and School of Medicine, Pittsburgh, PA

BOARD CERTIFICATION

> Diplomate, Clinical Cytogenetics, American Board of Medical Genetics

PROFESSIONAL ACTIVITIES

PUBLICATIONS

[Refereed Articles]{.underline}

1\. **Gollin SM**, and King RC: Studies of *fs(1)1621*, a mutation that
produces ovarian tumors in *Drosophila melanogaster. Develop. Genetics*
1981; 2:203‑218.

2\. Hanks SK, **Gollin SM**, Rao PN, Wray W, and Hittelman WN: Cell
cycle‑specific changes in the ultrastructural organization of
prematurely condensed chromosomes. *Chromosoma* 1983; 88:333‑342.

3\. **Gollin SM**, and Wray W: A multisample chamber for dehydration and
critical point drying. *J. Electron Microscopy Technique* 1984;
1:199‑201.

4\. **Gollin SM**, and Wray W: Isopycnic centrifugation of mammalian
metaphase chromosomes in Nycodenz. *Exp. Cell Res.* 1984; 152:204‑211.

5\. **Gollin SM**, Wray W, Hanks SK, Hittelman WN, and Rao PN: The
ultrastructural

organization of prematurely condensed chromosomes. *J. Cell Sci. Suppl.*
1984; 1:203‑221.

6\. **Gollin SM**, Leary JF, Shoulson I, and Doherty RA: Flow cytometric
detection of lymphocyte alterations in Huntington\'s disease. *Life
Sci.* 1985; 36:619‑626.

7\. **Gollin SM**, Holmquist GP, and Ledbetter DH: Fra(10)(q25): The
BrdU effect is

substitution‑dependent. *Am. J. Hum. Genet.* 1985; 37:208‑214.

8\. **Gollin SM**, Bock HGO, Caskey CT, and Ledbetter DH: A new family
with fra(10)(q25): Spontaneous expression and 100% expression with l00
uM BrdU. *Am. J. Med. Genet.* 1985; 2l:643‑648.

9\. **Gollin SM**, Perrot LJ, Gray BA, and Kletzel M: Spontaneous
expression of fra(11)(q23) in a patient with Ewing\'s sarcoma and
t(11;22)(q23;q11). *Cancer Genet. Cytogenet.* 1986; 20:331‑339.

10\. Kletzel M, **Gollin SM**, Gloster ES, Golladay ES, Jimenez JF, and
Berry DH: Chromosome abnormalities in familial hemophagocytic
lymphohistiocytosis. *Cancer* 1986; 57(11):2513‑2517.

11\. Reynolds JF, Daniel A, Kelly TE, **Gollin SM**, Stephan MJ, Carey
J, Adkins WN, Webb MJ, Char F, Jimenez JF, and Opitz J: Isochromosome
12p mosaicism (Pallister mosaic aneuploidy or Pallister‑Killian
syndrome): Report of 11 cases. *Am. J. Med. Genet.* 1987; 27:257‑274.

12\. Gray BA, and **Gollin SM**: Rapid cell culture procedure for tissue
samples. *Am. J. Med. Genet.* 1987; 28:521‑526.

13\. Chadduck WM, **Gollin SM**, Gray BA, Norris JS, Araoz CA, and Tryka
AF: Gliosarcoma with chromosome abnormalities in a neonate exposed to
heptachlor. *Neurosurgery* 1987; 21: 557‑559.

14\. Pettigrew AL, **Gollin SM**, Greenberg F, Riccardi VM, and
Ledbetter DH: Duplication of proximal 15q as a cause of Prader‑Willi
Syndrome. *Am. J. Med. Genet.* 1987; 28:791‑802.

15\. Edwards DR, Keppen LD, Ranells JD, and **Gollin SM**: Autism in
association with fragile X syndrome in females: Implications for
diagnosis and treatment in children. *NeuroToxicology* 1988;
9(3):359‑365.

16\. Keppen LD, Fasules JW, Burks AW, **Gollin SM**, Sawyer JR, and
Miller CH: Confirmation of autosomal dominant transmission of the
DiGeorge malformation complex. *J. Peds.* 1988; 113:506‑508.

17\. Przepiorka D, **Gollin SM**, Sulecki M, and Zeigler Z: The use of
in situ hybridization for detection of loss of the Y chromosome in
normal males and in the evaluation of elderly males with pancytopenia.
*Hematologic Pathol.* 1989; 3:177-183.

18\. Heo DS, Snyderman C, **Gollin SM**, Pan S, Walker E, Deka R, Barnes
EL, Johnson JT, Herberman RB, and Whiteside TL: New head and neck
squamous cell carcinoma cell lines: Biology, cytogenetics, and
sensitivity to immunologic effector cells. *Cancer Res.* 1989;
49:5167-5175.

19\. Storto PD, Saidman SL, Demetris AJ, Letissier E, Whiteside TL, and
**Gollin SM**:

Chromosomal breakpoints in cholangiocarcinoma cell lines. *Genes Chrom.
Cancer* 1990; 2:300-310.

20\. Keppen LD, **Gollin SM**, Seibert JJ, and Sisken JE: Roberts
Syndrome with normal cell division: A case report. *Am. J. Med. Genet.*
1991; 38:21-24.

21\. Sherer ME, Shekhter-Levin S, Krause JR, Joyce RA, and **Gollin
SM**: Atypical 7;19

translocation in acute myelomonocytic leukemia. *Cancer Genet.
Cytogenet.* 1991; 57:169-173.

22\. Keppen LD, **Gollin SM**, Edwards D, Sawyer J, Wilson W, and
Overhauser J: Clinical phenotype and molecular analysis of a
three-generation family with an interstitial deletion of the short arm
of chromosome 5. *Am. J. Med. Genet.* 1992; 44:356-360.

23\. Shimizu Y, Demetris AJ, **Gollin SM**, Storto PD, Bedford HM,
Altarac S, Iwatsuki S,

Herberman RB, and Whiteside TL: Establishment of two new human
cholangiocarcioma cell lines and their cytogenetics and responses to
growth factors, hormones, and cytokines or immunological effector cells.
*Intl. J. Cancer* 1992; 52:252-260.

24\. **Gollin SM**, Storto PD, Malone PS, Barnes L, Washington JA,
Chidambaram A, and Janecka I: Cytogenetic abnormalities in an ossifying
fibroma from a patient with bilateral retinoblastoma. *Genes Chrom.
Cancer* 1992; 4:146-152.

25\. Sankary S, Sherwin RN, Malone PS, Janecka I, Barnes L, Storto PD,
and Gollin SM: Clonal chromosomal aberrations in a leiomyosarcoma of the
sinonasal tract. *Cancer Genet. Cytogenet.* 1993; 65:21-26.

26\. Sankary S, Dickman PS, Wiener E, Robichaux W, Swaney WP, Malone PS,
and **Gollin SM**: Consistent numerical chromosome aberrations in
congenital fibrosarcoma. *Cancer Genet. Cytogenet.* 1993; 65:152-156.

27\. Roth AD, Oral A, Przepiorka D, **Gollin SM**, and Chervenick PA:
Chronic myelogenous leukemia and acute lymphoblastic leukemia occurring
in the course of polycythemia vera. *Am. J. Hematol.* 1993; 43:123-128.

28\. Shekhter-Levin S, Mirro J, Penchansky L, Sherer ME, Wald N, and
**Gollin SM**: Acute myeloblastic leukemia with a pericentric inversion
of chromosome 6 in a child with Down syndrome. *Cancer Genet.
Cytogenet.* 1994; 73: 157-160.

29\. Corey SJ, Locker J, Oliveri DR, Shekhter-Levin S, Redner R,
Penchansky L, and **Gollin SM**: A non-classical translocation involving
17q12 (retinoic acid receptor ) in acute promyelocytic leukemia with
atypical features. *Leukemia* 1994; 8:1350-1353.

30\. Randhawa PS, Zeevi A, Alvares C, **Gollin S**, Agostini R, Yunis E,
Saidman S, Contis L, Demetris AJ, Nalesnik MA: Morphologic and
immunophenotypic characterization of a cell line derived from liver
tissue with Epstein-Barr virus associated post-transplant
lymphoproliferative disease. *In Vitro Cell Develop. Biol.* 1994;
30A(6): 400-406.

31\. **Gollin SM** and Janecka I: Cytogenetics of cranial base tumors.
*J Neuro-0ncol.* 1994; 20:241-254.

32\. Lese CM, Rossie KM, Appel BN, Reddy JK, Johnson JT, Myers EN,
**Gollin SM**:

Visualization of INT2 and HST1 amplification in oral squamous cell
carcinomas. *Genes Chromosomes Cancer* 1995; 12:288-295.

33\. Shekhter-Levin S, Penchansky L, Wollman MR, Sherer ME, Wald N,
**Gollin SM**: An

abnormal clone with monosomy 7 and trisomy 21 in the bone marrow of a
child with congenital agranulocytosis (Kostmann Disease) treated with
granulocyte colony-stimulating factor: Evolution towards myelodysplastic
syndrome and acute basophilic leukemia. *Cancer Genet Cytogenet*. 1995
84:99-104.

34\. Law JC, Whiteside TL, **Gollin SM**, Weissfeld J, El-Ashmawy L,
Srivastava S, Landreneau RJ, Johnson JT, and Ferrell RE: Variation of
p53 mutational spectra between carcinoma of the upper and lower
respiratory tract. *Clin Cancer Res.* 1995; 1:763-768.

35\. Ishwad C, Ferrell RE, Rossie KM, Appel BN, Johnson JT, Myers EN,
Law JC, Srivastava S, **Gollin SM**: Loss of heterozygosity of the short
arm of chromosomes 3 and 9 in oral cancer. 1996; *Intl J Cancer* 69:1-4.

36\. Welch WC, Morrison RS, Gross JL, **Gollin SM**, Kitson RB, Goldfarb
RH, Giuliano KA, Bradley MK, Kornblith PL: Morphologic, immunologic,
biochemical and cytogenetic characterization of the human
glioblastoma-derived cell line, SNB-19. *In Vitro Cell. Develop. Biol.*-
Animal 1995; 31(8):610-616.

37\. Ishwad C, Ferrell RE, Rossie KM, Appel BN, Johnson JT, Myers EN,
Law JC, Srivastava S, **Gollin SM**: Microsatellite instability in oral
cancer. *Intl J Cancer*. 1995; 64:332-335.

38\. Maeurer MJ, **Gollin SM**, Martin D, Swaney W, Bryant J, Castelli
C, Robbins P, Parmiani G, Storkus WJ, Lotze M: Tumor escape from immune
recognition - Lethal recurrent melanoma in a patient associated with
downregulation of the peptide transporter protein TAP‑1 and loss of
expression of the immunodominant MART‑1/MELAN‑A antigen. *J Clin Invest*
1996; 98(7):1633‑1641.

39\. Maeurer MJ, **Gollin SM**, Storkus WJ, Swaney W, Karbach J, Martin
D, Castelli C, Salter R, Knuth A, Lotze MT: Tumor escape from immune
recognition: Loss of HLA-A2 melanoma cell surface expression is
associated with a complex rearrangement of the short arm of chromosome
6. *Clin Cancer Res* 1996;2:641-652.

40\. Rowley JD, Vignon C, **Gollin SM**, Rosenberg CL, Wyandt HE,
Milunsky A: Chromosomal translocations in secondary acute myeloid
leukemia. *New Engl J Med* 1996; 334:601-603.

41\. Virgilio L, Shuster M, **Gollin SM**, Veronese ML, Ohta M, Huebner
K, Croce CM: *FHIT* gene alterations in head and neck squamous cell
carcinomas. *Proc Natl Acad Sci USA* 1996; 93:9770-9775.

42\. Shekhter-Levin S, Bloom EJ, Swerdlow SH, Sherer ME, Wald N,
**Gollin SM**: Acquired monosomy 7 in donor cells in a patient treated
for acute lymphoblastic leukemia with bone marrow transplantation.
*Cancer Genet Cytogenet* 1997: 95:190-197.

43\. Baysal BE, Farr JE, Rubenstein WS, Galus RA, Johnson KA, Aston CE,
Myers EN, Johnson JT, Carrau R, Kirkpatrick SJ, Myssiorek D, Singh D,
Saha S, **Gollin SM**, Evans GA, James MR, Richard CW III: Fine mapping
of an imprinted gene for familial nonchromaffin paragangliomas, on
chromosome 11q23. *Am J Hum Genet* 1997; 60:121-132.

44\. Dickman PS, Barmada M, **Gollin SM**, Blatt J: Malignancy following
retinoblastoma:

Secondary cancer or recurrence? *Human Pathol* 1997; 28:200-205.

45\. Pollack IF, Hamilton RL, Finkelstein SD, Campbell JW, Martinez AJ,
Sherwin RN, Bozik ME, **Gollin SM**: The relationship between TP53
mutations and overexpression of p53 and prognosis in malignant gliomas
of childhood. *Cancer Res* 1997; 57:304-309.

46\. Shuster M, Bockmühl U, **Gollin SM**: Early experiences with SKY: A
primer for the

practicing cytogenetic technologist. *Applied Cytogenet* 1997; 23
(2):33-37.

47\. Randhawa P, Whiteside T, Zeevi A, Nalesnik M, Alvares C, **Gollin
SM**, Demetris J, Locker J: In vitro culture of B-lymphocytes derived
from Epstein-Barr virus-associated posttransplant lymphoproliferative
disease: Cytokine production and effect of interferon-alpha. *In Vitro
Cell Dev Biol - Animal* 1997; 33:803-808.

48\. Shekhter-Levin S, Ball E, Swerdlow SH, Li WV, Kapadia SB, Sherer
ME, Wald N, **Gollin SM**: A near-haploid bone marrow karyotype in
systemic mast cell disease: Is it characteristic of the disease or an
incidental finding? *Cancer Genet Cytogenet* 1998; 103:124-129.

49\. McLaughlin MR, **Gollin SM**, Lese CM, Albright AL: Medulloblastoma
and glioblastoma multiforme in a patient with Turcot Syndrome: Case
Report. *Surg Neurol* 1998; 49:295-301.

50\. Baysal BE, Potkin SG, Farr JE, Higgins MJ, Korcz J, **Gollin SM**,
James MR, Evans GA, Richard CW III: Bipolar affective disorder partially
cosegregates with a balanced t(9;11)(p24;q23.1) chromosomal
translocation in a small pedigree. *Am J Med Genet* 1998; 81:81-91.

51\. Shuster M, Dhar MS, Olins AL, Olins DE, Howell CY, **Gollin SM**,
Chaillet JR: Parental alleles of an imprinted mouse transgene replicate
synchronously. *Develop Genet* 1998; 23:275-284.

52\. Ishwad CS, Shuster M, Bockmuhl U, Thakker N, Shah P, Toomes C,
Dixon M, Ferrell RE, **Gollin SM**: Frequent allelic loss and homozygous
deletion in chromosome band 8p23 in oral cancer. *Int J Cancer* 1999;
80:25-31.

53\. Nussler AK, Vergani G, **Gollin SM**, Dorko K, Gansauge S, Morris
SM, Demetris AJ, Nomoto M, Beger HG, Strom SC: Isolation and
characterization of a human hepatic epithelial-like cell line (AKN-1)
from a normal liver. *In Vitro Cell. Dev. Biol. - Animal* 1999;
35:190-197.

54\. Welch WC, Kornblith PL, Michalopoulos GK, Peterson BE, Beedle A,
**Gollin SM**, Goldfarb RH: Hepatocyte growth factor (HGF) and receptor
(c-met) in normal and malignant astrocytic cells. *Anticancer Research*
1999; 19:1635-1640.

55\. Saunders WS, Shuster M, Huang X, Gharaibeh B, Enyenihi AH, Petersen
I, **Gollin SM**: Chromosomal instability and cytoskeletal defects in
oral cancer cells. *Proc Natl Acad Sci USA* 2000; 97:303-308.

56\. Shuster M, Han L, LeBeau MM, Davis E, Sawicki M, Lese CM, Park N-H,
Colicelli J, **Gollin SM**: A consistent pattern of *RIN1*
rearrangements in oral squamous cell carcinoma cell lines supports a
breakage-fusion-bridge cycle model for 11q13 amplification. *Genes
Chromosomes Cancer* 2000; 28:153-163.

57\. Shekhter‑Levin S, **Gollin SM**, Kaplan SS, Redner RL: Involvement
of the MLL and RAR alpha genes in a patient with acute monocytic
leukemia with t(11;17)(q23;q12). *Leukemia* 2000; 14:520-522.

58\. Woolley PV, **Gollin SM**, Riskalla W, Finkelstein S, Stefanik DF,
Riskalla L, Swaney WP, Weisenthal L, McKenna RJ Jr: Cytogenetics,
immunostaining for fibroblast growth factors, p53, sequencing, and
clinical features of two cases of cystosarcoma phyllodes. *Mol. Diagn.*
2000; 5:179-190.

59\. **Gollin SM**: Chromosomal Alterations in Squamous Cell Carcinomas
of the Head and Neck: Window to the Biology of Disease. *Head & Neck*
2001; 23:238-253.

60\. Rao UNM, **Gollin SM**, Beaves S, Cieply K, Nalesnik M,
Michalopoulos GK: Comparative genomic hybridization of hepatocellular
carcinoma: Correlation with fluorescence in situ hybridization in
paraffin embedded tissue. *Mol. Diagn.* 2001; 6:27-37.

61\. Bockmühl U, Ishwad CS, Ferrell RE, **Gollin SM**: Association of
8p23 deletions with poor survival in head and neck cancer**.**
*Otolaryngology-Head & Neck Surg* 2001; 124:451-455.

62\. Sun PC, Uppaluri R, Schmidt AP, Pashia ME, Quant EC, Sunwoo JB,
**Gollin SM**, Scholnick SB: Transcript map of the 8p23 putative tumor
suppressor region. *Genomics* 2001; 75:17‑25.

63\. Hu J, McPherson E, Surti U, Hasegawa SL, Gunawardena S, **Gollin
SM**: Tetrasomy 15q25.3 qter Resulting from an Analphoid Supernumerary
Marker Chromosome in a Patient with Multiple Anomalies and Bilateral
Wilms Tumors. *Am J Med Genet* 2002; 113:82-88.

64\. Huang X, **Gollin SM**, Raja S, Godfrey TE: High resolution mapping
of the 11q13 amplican in oral squamous cell carcinoma cells:
Identification of a new gene that is overexpressed in oral cancer. *Proc
Natl Acad Sci USA* 2002; 99(17):11369-11374.

65\. Reshmi‑Skarja S, Huebner A, Handschug K, Finegold DN, Clark AJL,
**Gollin SM**: Chromosomal Fragility in Patients with Triple A Syndrome.
*Am J Med Genet* 2003; 117A:30-36.

66\. Toomes C, Jackson A, Maguire K, Wood J, **Gollin S**, Ishwad C,
Paterson I, Prime S, Parkinson K, Bell S, Woods G, Markham A, Oliver R,
Woodward R, Sloan P, Dixon M, Read A, Thakker N: The presence of
multiple regions of homozygous deletion at the *CSMD1* locus in oral
squamous cell carcinoma question the role of CSMD1 in head and neck
carcinogenesis. *Genes Chromosomes Cancer* 2003;37:132-140.

67\. Telmer CA, An J, Malehorn DE, Zeng X, **Gollin SM**, Ishwad CS,
Jarvik JW: Detection and assignment of *TP53* mutations in tumor DNA
using peptide mass signature genotyping. *Human Mutation* 2003;
22:158-165.

68\. Reing JE, **Gollin SM**, Saunders WS: The occurrence of chromosome
segregational effects is an intrinsic and heritable property of oral
squamous cell carcinoma cell lines. *Cancer Genet Cytogenet* 2004;
150:57-61.

69\. **Gollin SM**: Chromosomal instability. *Curr Opin Oncol* 2004;
15:25-31.

70\. Ragin CCR, Reshmi SC, **Gollin SM**: Mapping and analysis of HPV16
integration sites in a head and neck cancer cell line. *Int J Cancer*
2004; In Press.

71\. Hewitt C, Wilson P, McGlinn E, MacFarlane G, Papageorgiou A,
Woodwards RTM, Sloan P, **Gollin SM**, Patterson I, Parkinson KK, Read
AP, Thakker N: DLC1 is unlikely to be a primary target for deletions on
chromosome arm 8p22 in head and neck squamous cell carcinoma. *Cancer
Lett* 2004; In Press.

72\. Cook JR, Aguilera I, Reshmi-Skarja S, Huang X, Yu Z, Gollin SM,
Abbondanzo SL, Swerdlow SH: Lack of PAX5 rearrangements in
lymphoplasmacytic lymphomas: Reassessing the reported association with
t(9;14). *Hum Pathol* 2004; In Press.

[Selected Reviews]{.underline}, [Invited]{.underline}
[Published]{.underline} [Papers,]{.underline} [Proceedings]{.underline}
[of]{.underline} [Conferences]{.underline} [and]{.underline}
[Symposia,]{.underline} [Monographs,]{.underline} [Books]{.underline}
[and]{.underline} [Book]{.underline} [Chapters]{.underline}

**Gollin SM**: Cancer Cytogenetics. pp. 135-142. In: *Hematology:
Clinical and Laboratory Practice.* Bick RL, Ed., Mosby-Year Book, Inc.,
St. Louis. 1993.

**Gollin SM**: Genetic mapping. pp. 199‑202. In: *1986 McGraw-Hill
Yearbook of Science and Technology.* McGraw‑Hill Book Co., New York.
1985.

**Gollin SM**, Reshmi‑Skarja S (2003) Mitosis: Chromosomal
Rearrangements During. In: *Encyclopedia of the Human Genome*. Nature
Publishing Group, London.

**Gollin SM** (November 2003) Cell Culture Contamination. In: *Nature
Encyclopedia of Life Sciences*. London: Nature Publishing Group.
http://www.els.net/   \[doi:10.1038/npg.els.0002560\]

**Gollin SM** (2004) Acquired chromosome abnormalities: the cytogenetics
of cancer. In: Encyclopedia of Genetics, Genomics, Proteomics and
Bioinformatics. L. Jorde, Ed. John Wiley and Sons, London. In Press,
February, 2004.