**CURRICULUM VITAE**

**ROBERT CARLTON SILLS**

**[PERSONAL DATA]{.underline}**

Business: Environmental Toxicology Program

Laboratory of Experimental Pathology

National Institute of Health

National Institute of

Environmental Health Sciences

P.0. Box 12233, MD B3-08

Research Triangle Park, N.C. 27709

\(919\) 541-0180

**[QUALIFICATIONS AND EDUCATION]{.underline}**

1991 Diplomate of the American College of

Veterinary Pathologists (ACVP)

1991 Ph.D., Veterinary Pathology

College of Veterinary Medicine

Michigan State University

East Lansing, Michigan

1984 Doctor of Veterinary Medicine

Tuskegee University, Alabama

1982 Bachelor of Science in Animal

and Poultry Science

Tuskegee University, Alabama

**[PROFESSIONAL EXPERIENCE]{.underline}**

Head, Molecular Pathology, Laboratory of Experimental Pathology,
National Institute of Environmental Health Sciences (NIEHS), Research
Triangle Park, North Carolina, 1997 - Present.

Toxicologic Pathologist, NTP, NIEHS, Research Triangle Park, North
Carolina, June

1991 - 1997.

Project Officer, National Toxicology Program (NTP) Archives and Frozen
Tissue Bank, Research Triangle Park, North Carolina, December 1993 -
1996

Pathology Doctoral Training, Toxicologic Pathology, Department of
Pathology,

Michigan State University, East Lansing, Michigan, October 1987 - June
1991.

Pathologist in Training, Biomedical Science Department, Research
Laboratories,

General Motors, Warren, Michigan, July 1987 - October 1987.

Pathology Resident, Anatomic and Surgical Pathology, Animal Health
Diagnostic

Laboratory, Michigan State University, East Lansing, Michigan, July
1985 - June 1987.

Pathology Intern, Anatomic and Surgical Pathology, Depart­ment of
Pathology, School

of Veterinary Medicine, Tuskegee University, June 1984 - June 1985.

Small Animal Clinic, School of Veterinary Medicine, Tuskegee University,

Preceptorship, December 1983 - January 1984.

**[RESEARCH EXPERIENCE]{.underline}**

Study design leader for clear air act chemical, carbonyl sulfide.
Collaborative neurotoxicity and magnetic resonance microscopy (MRM)
studies: Environmental Protection Agency, Duke University, NTP, NIEHS,
Research Triangle Park, North Carolina, 1998 - Present.

Study design leader for clear air act chemical, carbon disulfide.
Collaborative neurotoxicity and atherosclerosis studies: Environmental
Protection Agency, Duke University, University of North Carolina and
Vanderbilt University. NTP, NIEHS, Research Triangle Park, North
Carolina, June 1992 - Present.

Oncogene and tumor suppressor gene alterations in NTP chemical
carcinogenesis studies. NTP, NIEHS, Research Triangle Park, North
Carolina, June 1991 - Present.

Tumor promoting effects, morphological evaluation and
immunohistochemical

detection of the oncogene product [ras]{.underline} p21 in preneoplastic
and neoplastic

hepatocellular lesions of initiated rats treated with phenobarbital
and/or 2,3,7,8-

tetrachlorodibenzo-p-dioxin. Ph.D. research, Michigan State University,
1987 - 1991.

# 

# PUBLICATIONS

Dunnick, J.K, Burka, L.T., Mahler, J. and **Sills, R.C**: Carcinogenic
potential of o-nitrotoluene and p-nitrotoluene. Toxicology, 183: 221,
2003.

Turusov, V.S., Torii, M., **Sills, R.C.**, Willson, G.A., Herbert, R.A.,
Hailey, J.R., Haseman, J.K. and Boorman, G.A. Hepatoblastomas in mice in
the US National Toxicology Program (NTP) studies. Toxicologic.
Pathology, 30: 580, 2002.

Devereux, T.R., Holliday, W., Anna, C., Ress, N., Roycroft, J. and
**Sills, R.C.**: Map kinase activation correlates with K-ras mutation
and loss of heterozygosity on chromosome 6 in alveolar bonchiolar
carcinomas from B6C3F1 mice exposed to vanadium pentoxide for 2 years.
Carcinogenesis, 23: 1737, 2002.

Zhang, Z., Wang, Y., Vikis, H.G., Johnson, L., Liu, G., Li, J.,
Anderson, M.W., **Sills, R.C**., Hong, H.L, Devereux, T.R., Jacks, T.,
Guan, K., You, M.: Wildtype K-[ras]{.underline} can inhibit lung
carcinogenesis in mice. Nature Genetics, 29: 25, 2001.

Williams, K.D., Dunnick, J., Horton, J., Greenwell, A., Eldridge, S.R.,
Elwell, M. and

**Sills, R.C.**: p-Nitrobenzoic acid α~2μ~ nephropathy is not associated
with renal

carcinogenesis in 2 year feed studies. Toxicologic Pathology, 29: 507,
2001.

Harry, G.J., **Sills, R.C.**, Schlosser, M.J. and Maier, W.E.:
Neurodegeneration and glia

response in rat hippocampus following nitro-L-argine methyl ester
(L-NAME).

Neurotoxicology Research, 3: 307, 2001.

Melnick, R.L. and **Sills, R.C.**: Comparative carcinogenicity of
1,3-butadiene, isoprene and chloroprene in rats and mice.
Chemico-Biological Interactions, 135-136: 27, 2001.

**Sills, R.C.**, Hong, H.L., Boorman, G.A., Devereux, T.R. and Melnick,
R.L.: Point mutations of K-[ras]{.underline} and H-[ras]{.underline}
genes in forestomach neoplasms from control B6C3F1 mice and following
exposure to 1,3-butadiene, isoprene or chloroprene for up to 2-years.
Chemico-Biological Interactions, 135-136: 373, 2001.

Hayashi, S., Hong, H.L., Toyoda, K. Ton. T.T., Devereux, T.R., Maronpot,
R.R., Huff, J. and **Sills, R.C.**: High frequency of [ras]{.underline}
mutations in forestomach and lung tumors of B6C3F1 mice exposed to
1-amino-2,4-dibromoanthraquinone for 2 years. Toxicologic Pathology, 29:
1, 2001.

Ma, M., Devereux, T.R., Stockton, P., Sun, K., **Sills, R.C.**, Clayton,
N., Portier, M. and Flake, G.: Loss of E-cadherin expression in gastric
intestinal metaplasia and later stage [p53]{.underline} altered
expression in gastric carcinogenesis. Experimental and Toxicologic
Pathology, 53: 237, 2001.

**Sills, R.C.**, French, J.E. and Cunningham, M.L.: New models for
assessing

carcinogenesis: An ongoing process. Toxicology Letters, 120: 187, 2001.

Hong, H.L., Devereux, T.R., Melnick, R.L., Moomaw, C.R., Boorman, G.A.
and

**Sills, R.C.**: Mutations of [ras]{.underline} protooncogenes and
[p53]{.underline} tumor suppressor gene in cardiac hemangiosarcomas from
B6C3F1 mice exposed to 1,3-butadiene for 2 years. Toxicologic Pathology,
28: 529, 2000.

Boorman, G.A., McCormick, D.L., Ward, J.M., Haseman, J.K. and **Sills,
R.C.**: Magnetic fields and mammary cancer in rodents: A critical review
and evaluation of published literature. Radiation Research, 153: 617,
2000.

Anna, C.H., **Sills, R.C.**, Foley, J.F., Stockton, P.S., Ton, T. and
Devereux, T.R.: β-catenin mutations and protein accumulation in all
hepatoblastomas from B6C3F1 mice

treated with anthraquinone or oxazepam. Cancer Research, 60: 2864, 2000.

Boorman, G.A., Rafferty, C.M., Ward, J.M. and **Sills, R.C.**: A review
of leukemia and

lymphoma incidence in rodents exposed to low frequency magnetic fields.

Radiation Research, 153: 627, 2000.

**Sills, R.C.,** Valentine, W.M., Moser, V., Graham, D.G. and Morgan,
D.L.:

Characterization of carbon disulfide neurotoxicity in C57BL6 mice:
Behavioral,

morphological and molecular effects. Toxicologic Pathology, 28: 142,
2000.

Walker, N.J., Tritscher, A.M., **Sills, R.C.**, Lucier, G.W. and
Portier, C.J.: Hepato-

carcinogenesis in female Sprague-Dawley rats following discontinuous
treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicological
Sciences, 54: 330, 2000.

Anderson, L.E., Boorman, G.A., Morris, J.E., Sasser, L.B., Mann, P.C.,
Grumbein, S.L.

Hailey, J.R., McNally, A., **Sills, R.C.** and Haseman, J.K.: Effect of
13 week magnetic field exposures on DMBA-initiatied mammary gland
carcinomas in female Sprague-Dawley rats. Carcinogenesis 20: 1615, 1999.

Devereux, T.R., Anna, C.H., Foley, J.F., White, C.M., **Sills, R.C.**
and Barrett, J.C.:

Mutation of β-Catenin is an early event in chemically induced mouse
hepatocellular carcinogenesis. Oncogene, 18: 4726, 1999.

**Sills, R.C.**, Hailey, J.R., Neal, J., Boorman, G.A., Haseman, J.K.
and Melnick, R.L.:

Examination of low incidence brain tumor responses in F344 rats
following chemical exposures in National Toxicology Program Studies.
Toxicologic Pathology, 27: 589, 1999.

Lewis, J.G., Graham, D.G., Valentine, W.M., Morris, R.W., Morgan, D.L.,
**Sills, R.C**.:

Exposure of C57BL/6 mice to carbon disulfide induced early lesions of

atherosclerosis and enhances arterial fatty deposits induced by a high
fat diet. Toxicological Sciences, 49: 124, 1999.

McCormick, D.L., Boorman, G.A., Findlay, J.C., Hailey, J.R., Johnson,
T.R., Gauger,

J.R., Plecher, J.M., **Sills, R.C.** and Haseman, J.K.: Chronic
toxicity/carcinogenicity

evaluation of 60 Hz (power frequency) magnetic fields in B6C3F1 mice.
Toxicologic Pathology, 27: 279, 1999.

Bucher, J.R., Hailey, J.R., Roycroft, J.R, Haseman, J.K, **Sills,
R.C.**, Grumbein, S.L, Mellick, P.W., Chou, B.J.: Inhalation toxicity
and carcinogenicity studies with cobalt sulfate. Toxicological Sciences,
49: 56, 1999.

**Sills, R.C.**, Hong, L.H., Melnick, R.L., Boorman, G.A., and Devereux,
T.R. High frequency of codon 61 K-[ras]{.underline} A to T transversions
in lung and Harderian gland neoplasms of B6C3F1 mice exposed to
chloroprene (2-chloro-1,3-butadiene) for 2-years, and comparisons with
the structurally related chemicals isoprene and 1,3-butadiene.
Carcinogenesis, 20: 657, 1999.

Boorman, G.A., McCormick, D.L., Findlay, J.C., Hailey, J.R., Gauger,
J.R., Johnson, T.R., Kovatch, R.M., **Sills, R.C.** and Haseman, J.K.:
Chronic toxicity/oncogenicity evaluation of 60 Hz (power frequency)
magnetic fields in F344 rats. Toxicologic Pathology, 27: 267, 1999.

Melnick, R.L., **Sills, R.C.**, Portier, C.J., Roycroft, J.H., Chou,
B.J., Brunbein ,S.L., Miller, R.A.: Chronic toxicity and carcinogenicity
of inhaled chloroprene (2-chloro-1,3,-butadiene) in F344/N rats and
B6C3F1 mice and comparison of dose-response with 1,3-butadiene in mice.
Carcinogenesis, 20: 867, 1999.

Boorman, G.A., Anderson, L.E., Morris, J.E., Sasser, L.B., Mann, P.C.,
Grumbein, S.L., Hailey, J.R., McNally, A., **Sills, R.C.** and Haseman,
J.K.: Effect of 26 week magnetic field exposures in a DMBA
initiation-promotion mammary gland model in Sprague-Dawley Rats.
Carcinogenesis, 20: 899, 1999.

Boorman, G.A., Dellarco, V., Dunnick, J.K., Chapin, R.E., Hunter, S.,
Hauchman, F., Gardner, H., Cox, M. and **Sills, R.C.**: Drinking water
disinfection by-products: Review and approach to toxicity evaluation.
Environmental Health Perspectives, 107: 207,

1999\.

Erve, J.C.L., Amarnath, V., **Sills, R.C**., Morgan, D.L. and Valentine,
W.M.:

Characterization of a valine-lysine thiourea cross-link on rat globin
produced by

carbon disulfide or *N,N*-diethyldithiocarbamate in vivo. Chemical
Research and

Toxicology, 18: 1128, 1998.

Hong, H.L., Devereux, T.R., Roycroft, J.H., Boorman, G.A. and **Sills,
R.C.**: Frequency of [ras]{.underline} mutations in liver neoplasms from
B6C3F1 mice exposed to tetrafluoroethylene for 2 years. Toxicologic
Pathology, 26: 646, 1998.

Erve, J.C.L., Amarnath, V., Graham, D.G., **Sills, R.C**., Morgan, D.L.
and Valentine, W.M.: Carbon disulfide and *N,N*-diethyldithiocarbamate
generate thiourea cross-links on erythrocyte spectrin *in vivo*.
Chemical Research and Toxicology, 18: 544, 1998.

Trukhanova, L.S., Hong, H.L., **Sills, R.C.**, Bowser, A.D., Gaul, B.,
Boorman, G.A., Turusov, V.S., Devereux, T.R. and Dixon, D.: Predominant
[p53]{.underline} G to A transition mutation and enhanced cell
proliferation in uterine sarcomas of CBA mice treated with
1,2-dimethylhydrazine. Toxicologic Pathology, 26: 367, 1998.

**Sills, R.C.**, Morgan, D.L. and Harry, G.J.: Carbon disulfide
neurotoxicity in rats: I. Introduction and study design.
NeuroToxicology, 19: 83, 1998.

Moorman, M., **Sills, R.C**., Collins, B.J., and Morgan, D.L.: Carbon
disulfide neurotoxicity in rats: II. Toxicokinetics, NeuroToxicology.
19: 89,1998.

Valentine, W.M., Amarnath, V., Amarnath, K., Erve, J.C.L., Graham, D.G.,
Morgan, D.L. and **Sills, R.C**.: Covalent modification of hemoglobin by
carbon disulfide: III. A potential biomarker of effect. NeuroToxicology,
19: 99, 1998.

Toews, A.D., Harry, G.J., Lowrey, K.B., Morgan, D.L. and **Sills,
R.C.**: Carbon disulfide neurotoxicity in rats: IV. Increased mRNA
expression of low-affinity nerve growth factor-receptor: A sensitive and
early indicator of PNS damage. NeuroToxicology, 19: 109, 1998.

**Sills, R.C.**, Harry, G.J., Morgan, D.L, Valentine, W.M. and Graham,
D.G. Carbon disulfide neurotoxicity in rats: V. Morphology of axonal
swelling in the spinal cord and muscular branch of the posterior tibial
nerve. NeuroToxicology, 19: 117, 1998.

Herr, D.W., Vo, K.T., Morgan, D.L. and **Sills, R.C.**: Carbon disulfide
neurotoxicity in rats: VI. Electrophysiological examination of caudal
tail nerve compound action potentials and nerve conduction velocity.
NeuroToxicology, 19: 129, 1998.

Moser, V.C., Phillips, P.M., Morgan, D.L. and **Sills, R.C.**: Carbon
disulfide neurotoxicity in rats: VII. Behavioral evaluations using a
functional observational battery. NeuroToxicology, 19: 147, 1998.

Harry, G.J., Graham, D.G., Valentine, M.V., Morgan, D.L and **Sills,
R.C.**: Carbon disulfide neurotoxicity in rats: VIII. Summary,
NeuroToxicology, 19: 159, 1998.

Hong, H.L., Devereux, T.R., Eldridge, S.R., Greenwell, A., Boorman, G.A.
and **Sills, R.C.**: Both K-[ras]{.underline} and H-[ras]{.underline}
protooncogene mutations are associated with Harderian tumorigenesis in
B6C3F1 mice exposed to isoprene for 26 weeks. Carcinogenesis, 18: 783,
1997.

Valentine, W.M., Amarnath, V., Graham, D.G., Morgan, D.L. and **Sills,
R.C.**: Carbon disulfide mediated cross-linking of erythrocyte spectrin
and neurofilament protein: Dose response and temporal relationship to
the formation of axonal swelling. Toxicology and Applied Pharmacology,
142: 95, 1997.

Chan, P.C., **Sills, R.C**., Braun, A.G., Haseman, J.K. and Bucher,
J.R.: Toxicity and carcinogenicity of tetrahydrocannabinol in Fischer
rats and B6C3F1 mice. Fund. Appl. Toxicology, 30:109, 1996.

Melnick, R.L., **Sills, R.C.**, Roycroft, J.H., Chou, B.J., Ragan, H.A.
and Miller, R.A.: Inhalation toxicity and carcinogenicity of isoprene in
rats and mice: Comparisons with 1,3-butadiene. Toxicology, 113: 247,
1996.

Herbert, R.A., Hailey, J., Grumbein, S., Chou, B.J., **Sills, R.**,
Haseman, J.K., Goehl, T., Mellick, P.W., Roycroft, J., and Boorman,
G.A.: Two-year and lifetime toxicity and carcinogenicity studies of
ozone in B6C3F1 mice. Toxicologic Pathology, 24: 539, 1996.

**Sills, R.C.**, Hong, L.H., Greenwell, A., Herbert, R.A., Boorman,
G.A., and Devereux, T.R. Increased frequency of K-[ras]{.underline}
mutations in lung neoplasms from female B6C3F1 mice exposed to ozone for
24 or 30 months. Carcinogenesis, 16: 1623, 1995.

Boorman, G.A., **Sills, R.C.**, Grumbein, S., Hailey, R., Miller, R.A.,
Herbert, R.A.: Long term toxicity studies of ozone in F344/N rats and
B6C3F1 mice. Toxicology Letters, 82: 301,1995.

Tritscher, A.M., Clark, G.C., Sewall, C., **Sills, R.C.**, Maronpot, R.,
and Lucier, G.W.: Persistence of TCDD-induced hepatic cell proliferation
and growth of enzyme altered foci after chronic exposure followed by
cessation of treatment in DEN initiated female rats. Carcinogenesis, 16:
2807, 1995.

**Sills, R.C.**, Goldsworthy, T.L., and Sleight, S.D.: Tumor promoting
effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and phenobarbital in
initiated weanling Sprague-Dawley rats: A quantitative, phenotypic and
[ras]{.underline} p21 protein study. Toxicologic Pathology, 22: 270,
1994.

Melnick, R.L., **Sills, R.C.**, Roycroft, J.H., Chou, B.J., Ragan, H.
A., and Miller, R.A.: Isoprene, an endogenous hydrocarbon and industrial
chemical, induces multiple organ neoplasia in rodents after 26 weeks of
inhalation exposure. Cancer Research, 54: 5333, 1994.

**Sills, R.C.**, Morgan, K.T., and Boorman, G. A.: Accessory nasal
structures in toxicology studies. Inhalation Toxicology, 6: 221, 1994.

Boorman, G.A., Hailey, R.R., Grumbein, S., Chou, B.J., Herbert, R.A.,
Goehl, R., Mellick, P.W., Roycroft, J.H., and **Sills, R.C.**:
Toxicology and carcinogenesis studies of ozone and ozone/NNK in F344/N
rats. Toxicologic Pathology, 22: 545, 1994.

Devereux, T.R., White, C.M., **Sills, R.C.**, Bucher, J.R., Maronpot,
R.R., and Anderson, M.W.: Low frequency of H-[ras]{.underline} mutations
in hepatocellular adenomas and carcinomas and in hepatoblastomas from
B6C3F1 mice exposed to oxazepam in the diet. Carcinogenesis, 15: 1083,
1994.

**Sills, R.C.**, Mullaney, T.P., Stickle, R.L., Darien, B.J., and Brown,
C.M.: Bilateral granulomatous guttural pouch infection due to
[Mycobacterium]{.underline} [avium]{.underline} complex in a horse.
Veterinary Pathology, 27: 133, 1990.

Kopcha, M., Marteniuk, J.V., **Sills, R.C.**, Steficek, B.A., and
Schillhorn van Veen: Cerebrospinal nematodiasis in a goat herd. Journal
American Veterinary Medical Association, 194: 1439, 1989.

**Sills, R.C.**, Dunstan, R.W., and Watson, G.L.: Pheochromocytomas in
two raccoon dogs. Veterinary Pathology, 25: 178, 1988.

Stickle, R., Parks, A., Marteniuk, J., Schultz, A. E., and **Sills,
R.C.**: Ameloblastic odontogenic neoplasia with secondary suppurative
osteomyelitis in a horse. Journal American Veterinary Medical
Association, 193: 582, 1988.

Dunstan, R.W., **Sills, R.C.**, Wilkinson, J.E., Paller, A.S., and
Hashimoto, K.E.: A disease resembling junctional epidermolysis bullosa
in a toy poodle. Am. J. Dermatopathology, 10: 442, 1988.

**[BOOK CHAPTERS]{.underline}**

Boorman, G.A., and **Sills, R.C.**: Ethyl acrylate. Predictive value of
rodent forestomach and gastric neuroendocrine tumours in evaluating
carcinogenic risk to humans. International Agency for Research on Cancer
Scientific Publications No. 39, pp 57-64, 2003.

Boorman, G.A., **Sills, R.C.**, and Haseman, J.K.: Methyl bromide.
Predictive value of rodent forestomach and gastric neuroendocrine
tumours in evaluating carcinogenic risk to humans. International Agency
for Research on Cancer Scientific Publications No. 39, pp 65-70, 2003.

**Sills, R.C.**, Boorman, G.A., Neal, J.E., Hong, H.L. and Devereux,
T.R.: Mutations in [ras]{.underline} genes in experimental tumors of
rodents. International Agency for Research on Cancer Scientific
Publications No. 146, pp 55-86, 1999.

Dixon, D., Herbert, R.A., **Sills, R.C.**, and Boorman, G.A.: Lungs,
pleura, and mediastinum. In Pathology of the B6C3F1 mouse, pp 293-332,
1999.

Boorman, G.A., and **Sills, R.C.**: The exocrine and endocrine pancreas.
In Pathology of the B6C3F1 mouse, pp 185-205, 1999.

Boorman, G.A., **Sills, R.C.**, and Hailey, J.A.: Preneoplastic and
neoplastic lesions of the rat and mouse thyroid. In Pathology of
Neoplasia and Preneoplasia, EULEP Color Atlas, Volume 2, pp 115-128,
1997.

Boorman, G.A., **Sills, R.C.**, and Eustis, S.L.: Acinar-cell
carcinomas, pancreas, rat. ILSI Monographs, 1995.

**[NTP PUBLICATIONS - MOLECULAR BIOLOGY STUDIES]{.underline}**

Devereux, T.R., Holliday, W., Roycroft, J.H., Ress, N.B., **Sills,
R.C.**: High frequency of K-ras mutations and loss of heterozygosity on
chromosome 6 in alveoloar/bronchioloar carcinomas from B6C3F1 mice
exposed to vanadium pentoxide for 2 years. NTP Technical Report on the
Toxicology and Carcinogenesis Studies of vanadium pentoxide in F344/N
rats and B6C3F1 mice. NTP TR 507, O1-O7, 2001.

**Sills, R.C.,** Hong, H.H, Ton, T.V., Dunnick, J.K, Devereux, T.R.:
Genetic alterations in [ras]{.underline}, [p53]{.underline} and
β-catenin genes in hemangiosarcomas of B6C3F1 mice following exposure to
o-nitrotoluene for 2 years. NTP Technical Report on the Toxicology and
Carcinogenesis Studies of o-nitrotoluene in F344/N rats and B6C3F1 mice.
NTP TR 504, M1-M11, 2001.

**Sills, R.C.**, Ton, T., Hayashi, S., Hong, H.L., Roycroft, J.H.,
Devereux, T.R.: Mutations of

β-catenin and H-[ras]{.underline} in hepatocellular adenomas and
carcinomas of B6C3F1 mice exposed to indium phosphide for 2 years. NTP
Technical Report on the Toxicology and Carcinogenesis Studies of indium
phosphide in F344/N rats and B6C3F1 mice. NTP TR 499, M1-M6, 2000.

Devereux, T.R., Anna, C.H., Foley, J.F., White, C.M., Barrett, J.C.,
**Sills, R.C.**: Mutation of β-catenin but not H-[ras]{.underline} in
hepatocellular adenomas and carcinomas of B6C3F1 mice treated with
methyleugenol for 2 years. NTP Technical Report on the Toxicology and
Carcinogenesis Studies of methyleugenol in F344/N rats and B6C3F1 mice.
NTP TR 491, R1-R5, 1998.

**Sills, R.C.**, Ton, T., Hong, H.L., Roycroft, J. R., Devereux, T.R.:
H-[ras]{.underline} codon 61 mutation spectra in forestomach neoplasms
from B6C3F1 mice exposed to 2-butoxyethanol for 2 years. NTP Technical
Report on the Toxicology and Carcinogenesis Studies of 2-butoxyethanol
in F344/N rats and B6C3F1 mice. NTP TR 484, L1-L5, 1998.

**Sills, R.C.**, Hong, H.L., Melnick, R., Devereux, T.R. and Boorman,
G.A.: K-[ras]{.underline} mutation frequency and spectra in lung and
Harderian gland neoplasms from B6C3F1 mice exposed to chloroprene for 2
years. NTP Technical Report on the Toxicology and Carcinogenesis Studies
of Chloroprene in F344/N rats and B6C3F1 mice. NTP TR 467, N1-N9, 1996.

**Sills, R.C.**, Neil, J., Hong, H.L., Bucher, J., Boorman, G.A. and
Devereux, T.R.: K-[ras]{.underline} mutation frequency and spectra in
lung neoplasms from B6C3F1 mice exposed to cobalt sulfate for 2 years.
NTP Technical Report on the Toxicology and Carcinogenesis Studies of
Cobalt Sulfate in F344/N rats and B6C3F1 mice. NTP TR 471, I1-I8, 1996.

**Sills, R.C.**, Hong, H.L., Roycroft, J., Devereux, T.R. and Boorman,
G.A.: H-[ras]{.underline} codon 61 mutation spectra in hepatocellular
neoplasms from B6C3F1 mice exposed to tetrafluoroethylene for 2 years.
NTP Technical Report on the Toxicology and Carcinogenesis Studies of
Tetrafluoroethylene in F344/N rats and B6C3F1 mice. NTP TR 450, L1-L8,
1995.

**[NTP PUBLICATIONS - PRINCIPAL PATHOLOGIST]{.underline}**

National Toxicology Program (2003). Toxicology and carcinogenesis
studies of 2-methylimidazole in F344/N rats and B6C3F1 mice (feed
studies). Technical Report 520, Carcinogenesis Testing Program, Research
Triangle Park, North Carolina.

National Toxicology Program (2002). Toxicology and carcinogenesis
studies of trans-cinnamaldehyde (microencapsulated) in F344/N rats and
B6C3F1 mice (feed studies). Technical Report 514, Carcinogenesis Testing
Program, Research Triangle Park, North Carolina.

National Toxicology Program (2001). Toxicology and carcinogenesis
studies of o-nitrotoluene in F344/N rats and B6C3F1 mice (feed studies).
Technical Report 504, Carcinogenesis Testing Program, Research Triangle
Park, North Carolina.

National Toxicology Program (2000). Toxicology and carcinogenesis
studies of sodium nitrite in F344/N rats and B6C3F1 mice (drinking water
studies). Technical Report 495, Carcinogenesis Testing Program, Research
Triangle Park, North Carolina.

National Toxicology Program (1998). Toxicology and carcinogenesis
studies of 60-HZ Magnetic Fields in F344/N rats and B6C3F1 mice (whole
body exposure studies). (Contributor to Pathology Assessment Team).
Technical Report 488, Carcinogenesis Testing Program, Research Triangle
Park, North Carolina (Participated as part of EMF Team).

National Toxicology Program (1997). Toxicology and carcinogenesis
studies of Isoprene in F344/N rats (inhalation studies). Technical
Report 486, Carcinogenesis Testing Program, Research Triangle Park,
North Carolina.

National Toxicology Program (1996). Toxicology and carcinogenesis
studies of Chloroprene in F344/N rats and B6C3F1 mice (inhalation
studies). Technical Report 467, Carcinogenesis Testing Program, Research
Triangle Park, North Carolina.

National Toxicology Program (1995). Toxicology and carcinogenesis
studies of Tetrafluoroethylene in F344/N rats and B6C3F1 mice
(inhalation studies). Technical Report 450, Carcinogenesis Testing
Program, Research Triangle Park, North Carolina.

National Toxicology Program (1994). Toxicology and carcinogenesis
studies of Isobutyl Nitrite in F344/N rats and B6C3F1 mice (inhalation
studies). Technical Report 448, Carcinogenesis Testing Program, Research
Triangle Park, North Carolina.

National Toxicology Program (1994). Toxicology and carcinogenesis
studies of 1-Trans-delta-tetrahydrocannabinol in F344/N rats and B6C3F1
mice (gavage study). Technical Report 446, Carcinogenesis Testing
Program, Research Triangle Park, North Carolina.

National Toxicology Program (1993). Toxicity studies of isoprene
administered by inhalation to F344/N rats and B6C3F1 mice. Toxicity
series, Number 31, Research Triangle Park, North Carolina.

National Toxicology Program (1993). Toxicology and carcinogenesis
studies of p-Nitrobenzoic acid in F344/N rats and B6C3F1 mice (feed
studies). Technical Report 442, Carcinogenesis Testing Program, Research
Triangle Park, North Carolina.

National Toxicology Program (1993). Toxicology and carcinogenesis
studies of tricresyl phosphate in F344/N rats and B6C3F1 mice (gavage
and feed studies). Technical Report 433, Carcinogenesis Testing Program,
Research Triangle Park, North Carolina.

National Toxicology Program (1992). Toxicology and carcinogenesis
studies of turmeric oleoresin in F344/N rats and B6C3F1 mice (feed
studies). Technical Report 427, Carcinogenesis Testing Program, Research
Triangle Park, North Carolina.

**[INVITED ORAL PRESENTATIONS]{.underline}**

"Application of magnetic resonance microscopy in a toxicologic pathology
setting", [Invited Speaker]{.underline}, International Life Sciences
Seminars on Advanced Pathologic Techniques, Emerging Technologies from
Microscopy to Non-invasive Imaging, New Orleans, Louisiana, December
2002.

"Molecular biology of tumors in B6C3F1 mice following inhalation
exposure to 1,3-butadiene, isoprene and chloroprene", [Invited
Speaker]{.underline}, International Symposium: Evaluation of Butadiene,
Isoprene and Chloroprene Health Risks, London, England, September 2000.

"New models for assessing carcinogenesis", [Invited
Speaker]{.underline}, EUROTOX 2000,

Imperial College, British Toxicology Society, London, England, September
2000.

"K-[ras]{.underline} mutations in lung tumors following chemical
exposure provide clues of

mechanisms of carcinogenesis in the B6C3F1 mouse", [Invited
Speaker]{.underline}, The Third

International Mouse Lung Tumorigenesis Symposium, Medical College of
Ohio, June 2000.

"Carbon disulfide neurotoxicity as a case study", [Invited
Speaker]{.underline}, Eighteenth International Symposium of Society of
Toxicologic Pathologists, Washington DC, June 1999.

"Mechanistic insights in toxicologic pathology evaluations" [Invited
Speaker]{.underline}, Thirty-fourth Annual Veterinary Medical Symposium,
Tuskegee University, Alabama, March 1999.

"Designing mechanistic studies" [Invited Speaker]{.underline}, Twenty
Second Annual C.L. Davis DVM Foundation Continuing Education Series -
International Symposium on Current Issues in Toxicologic Pathology,
North Carolina State University, Raleigh, June 1998.

"Mutations in ras genes in experimental tumours of rodents", [Invited
Speaker]{.underline},

Symposium on the Use of Short-term/Medium-term Predictive Tests for
Carcinogens and Data on Genetic and Related Effects in the International
Agency Research on Cancer (IARC) Monographs Evaluation Process, Lyon,
France, October 1997.

\"The role of the pathologist in hazard identification\"; [Invited
speaker]{.underline}, ILSI Pathology and Toxicology Institute/ILSI
Japan, ILSI Histopathology Seminar on Liver of Laboratory Animals, Nara,
Japan, May 1996.

\"Morphology of rodent liver tumors\"; [Invited speaker]{.underline},
ILSI Pathology and Toxicology Institute/ILSI Japan, ILSI Histopathology
Seminar on Liver of Laboratory Animals, Nara, Japan, May 1996.

"Impacts of the Safe Drinking Water Act Reauthorization on Health
Assessment and Research", [Invited Speaker]{.underline}, American Water
Works Association, Atlanta, Georgia, June 1997.

"Molecular Pathology Research in Mouse Carcinogenicity Studies",
[Invited speaker]{.underline}, Department of Pathology, Human Medicine
and Veterinary Medicine, Michigan State University, East Lansing,
Michigan, May 1997.

"Biologic and mechanistic evaluation of the neurotoxicity of carbon
disulfide", [Invited speaker]{.underline}, Current Concepts in
Toxicologic Pathology, Sponsored by the Department of Pharmacology and
Toxicology and the Institute for Environmental Toxicology, Michigan
State University, East Lansing, Michigan, May 1997.

"Critical issues in environmental research at the National Institute of
Environmental Health Sciences", [Invited speaker]{.underline}, Critical
Issues in Veterinary Medical Research III Conference, Washington DC,
January, 1997.

\"The National Toxicology Program at NIEHS: Opportunities in
toxicology\"; [Invited speaker]{.underline}, Society of Toxicology, 35th
Annual Meeting, Anaheim, California, March 1996.

\"Results of the NTP chronic bioassay, ozone studies\"; [Invited
speaker]{.underline}, The Tenth Health Effects Institute Annual
Conference, Reston, Virginia, May 1994.

\"Molecular analysis of lung neoplasms in female B6C3F1 mice following
ozone exposure\"; [Invited Speaker]{.underline}, NTP/HEI Collaborative
Ozone Studies, NTP, NIEHS, North Carolina, November, 1993.

\"Toxicology of accessory nasal structures\"; [Invited
speaker]{.underline}, Nasal Toxicity and Dosimetry of Inhaled
Xenobiotics: Implications for Human Health, Cosponsors: CIIT, EPA,
NIEHS, Washington Duke Inn and Golf Club, Durham, North Carolina,
September, 1993.

\"Molecular analysis of chloroprene-induced neoplasms in B6C3F1 mice\";
[Invited Speaker]{.underline}, Joint Environmental Carcinogenesis
Program and Environmental Toxicology Program Meeting, NIEHS, February
1993.

\"Tumor promoting effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and
phenobarbital in an initiation-promotion hepatocarcinogenesis model\";
[Invited speaker]{.underline}, Joint EPA and CIIT Dioxin Discussion
Group, January 1993.

\"Gastrointestinal toxicity of turmeric oleoresin in prechronic and
chronic dose-feed studies in Fischer 344 rats\"; [Invited
Speaker]{.underline}, Toxicologic Pathology Group, Annual Meeting of the
American College of Veterinary Pathologists, San Diego, California,
1992.

**[POSTER PRESENTATIONS SINCE 1990]{.underline}**

Hong, H.L., Devereux, T.R., Moomaw, C., Clayton, N., Dunnick, J. and
**Sills, R.C.**

Genetic alterations in β-catenin,p53 and K-ras genes and overexpression
of cyclin D1 contribute to o-nitrotoluene-induced large intestinal
carcinogenesis in B6C3F1 mice. The FASEB Journal, 2003.

Ton, T., Kim, Y., Hong, H., Melnick, R., Devereux, T. and **Sills, R**.:
Evaluation of 1,3-butadiene induced lung tumors for K-ras mutations and
p53 protein expression and allelic losses in the region of the K-ras
gene following inhalation for up to 52 weeks. Veterinary Pathology, Vol.
32, No. 5, p. 597, 2002.

Holliday, W., **Sills, R**., Roycroft, J., Ress, N., Devereux, T.
K-ras/Map kinase activation in lung carcinomas from B6C3F1 mice exposed
to vanadium pentoxide for 2 years. Proceedings of the American
Association for Cancer Research, 43: 1743, 2002.

Anna, C.H., **Sills, R.C**., Ton, T., Devereux, T. Cyclin D1 is a
nuclear target for β-catenin/Wnt signaling in chemically-induced
hepatocarcinogenesis in B6C3F1 mice. Proceedings of the American
Association for Cancer Research, 43: 1752, 2002.

Iida, M., Anna, C., Sieber, S., Bennett, L., Cunningham, M., **Sills,
R**., Paules, R. and Devereux, T.R. Changes in gene expression during
mouse liver carcinogenesis induced by nongenotoxic model carcinogens
oxazepam and Wyeth-14,643. Proceedings of the American Association for
Cancer Research, 43: 4265, 2002.

Hong, H.L., Ton, T.T., Devereux, T.R., Dunnick, J.K., and **Sills,
R.C.** Genetic alterations in ras, p53 and β-catenin genes in
hemangiosarcomas of B6C3F1 mice following exposure to o-nitrotoluene for
2 years. The FASEB Journal,16(5),partII,A1202, 904.3, 2002.

Hong,H.L.,Hayashi,S.M.,Toyoda,k.,Ton,T.T.,Devereux,T.R.,Maronpot,R.R.,and
**Sills, R.C.** High frequency of ras mutations in forestomach and lung
tumors induced by 1-amino-2,4-dibromoanthraquinone in mice. The FASEB
Journal,15(4),Part I,A249, 220.8., 2001.

Anna, C.H., **Sills, R.C.,** Foley, J.F., Stockton, P.S., Ton, T-V, and
Devereux, T.R.:

β-catenin mutations and protein accumulation in all chemically induced

hepatoblastomas examined from B6C3F1 mice. Proceedings of the American

Association for Cancer Research, 41, 686, 2000.

Hong, H.L, Devereux, T.R., Melnick, R.L., Boorman, G.A., **Sills,
R.C**.: Mutations of [ras]{.underline}

protooncogenes and [p53]{.underline} tumor suppressor gene in cardiac
hemangiosarcomas

from B6C3F1 mice exposed to 1,3-butadiene for 2 years. The FASEB
Journal, 14:

A1545, 2000.

Hong, H.L., Devereux, T.R., Boorman, G.A., and **Sills, R.C.**: Point
mutations of K-[ras]{.underline} and H-[ras]{.underline} genes in mouse
forestomach neoplasms induced by exposure to 1,3-butadiene, isoprene and
chloroprene. The FASEB Journal, 13: A188, 1999.

Anna, C.H., Foley, J.F., White, C.M., **Sills, R.C.**, Barrett, J.C. and
Devereux, T.R.: β- catenin mutations in chemically induced mouse
hepatocellular adenomas and carcinomas. Proceedings of the American
Association for Cancer Research, 40: 505, 1999.

Hong, H.L., Devereux, T.R., Boorman, G.A., and **Sills, R.C.**:
Predominant codon 61 K-[ras]{.underline} CTA mutation in lung and
Harderian gland neoplasms of B6C3F1 mice exposed to chloroprene or
isoprene. The FASEB Journal 12(S), A813, 4711, 1998.

**Sills, R.C.**, Maronpot, R.R., Hailey, R.H., and Boorman, G.A.:
Molecular analysis of lung neoplasms in B6C3F1 mice exposed to
chloroprene for 2-years provide additional chemical specific information
and mechanistic clues. Society of Toxicologic Pathologists 16th
International Symposium, Bever Creek, Colorado, 1997.

Hong, H.L., Devereux, T.R., Boorman, G.A., and **Sills, R.C.**:
Activated K-[ras]{.underline} proto-oncogenes in lung neoplasms of
B6C3F1 mice exposed to chloroprene. ASPET Meeting, San Diego, CA. The
Pharmacologist, 39: 151, 1997.

**Sills, R.C.**, Anna, C.H., White, C.M., Dunnick, J., Boorman, G.A.
and, Devereux, T.D.: K-[ras]{.underline} codon 12 mutation in B6C3F1
mice exposed to 2,2-Bis(Bromomethyl)-1,3-Propanediol for 2 years. Cancer
Susceptibility Genes and Molecular Carcinogenesis Special AACR
Conference, Keystone, Colorado, 1996.

Devereux, T.R., Anna, C.H., White, C.M., Patel, A., Hong, H.L., Massey,
T.E., and **Sills, R.C.**: Allelotype analysis of lung tumors from
different hybrid mouse strains in chromosomal regions linked to lung
tumor susceptibility. Cancer Susceptibility Genes and Molecular
Carcinogenesis Special AACR Conference, Keystone, Colorado, 1996.

Ito, N., La, D.K, Holt, S., Craft, T.R., **Sills, R.C.** and Swenberg,
J.A.: Analysis of [ras]{.underline} mutations in forestomach tumors from
B6C3F1 mice exposed to 1,2,3-trichloropropane. Proceedings of the
American Association for Cancer Research, Vol. 37, p. 137, 1996.

Valentine, W.M., Amarnath, V., Graham, D.G., Morgan, D.L., and **Sills,
R.C.**: Neurofilament protein and erythrocyte spectrin cross-linking
produced by inhalation of CS~2~. Society of Toxicology Annual Meeting,
1996.

**Sills, R.**, Graham, D., and Valentine, W.: Molecular mechanism of
carbon disulfide (CS~2~) distal axonopathy in F344 rats. Veterinary
Pathology, Vol. 32, No. 5, p. 597, 1995.

**Sills, R.**, Hong, H., Devereux, T., and Boorman, G.: Increased
frequency of CTA K-[ras]{.underline} and AAA H-[ras]{.underline}
mutations in Harderian gland neoplasms of B6C3F1 mice following 6 months
of isoprene exposure. Veterinary Pathology, Vol. 32, No. 5, p. 600,
1995.

**Sills, R.**, Graham, D., Morgan, D., and Moser, V.C.: Progression and
dose response of carbon disulfide (CS~2~) peripheral neuropathy in F344
rats. Veterinary Pathology, Vol. 32, No. 5, p. 600, 1995.

**Sills, R.C.**, Graham, D.G., Harry, G.J., Morgan, D.L., and Moser, V.:
Morphological and functional evaluation of carbon disulfide (CS~2~)
induced peripheral neuropathy in F344 rats. Society of Toxicology Annual
Meeting, 1995.

Lewis, J.G., **Sills, R.C.**, Morgan, D.L., Adams, D.O., and Graham,
D.G.: Alterations in macrophage function by exposure of mice to CS~2~
alone or in conjunction with an atherogenic high fat diet. Society of
Toxicology Annual Meeting, 1995.

Moorman, M.P., Goehl, T., Price, H.C., Collins, B.J., **Sills, R.C.**,
and Morgan, D.L.: Kinetic studies of carbon disulfide in male and female
Fischer 344 rats. Society of Toxicology Annual Meeting, 1995.

Toews, A.D., Harry, G.J., Lowrey, K.B., **Sills, R.C.**, Morgan, D., and
Morell, P.: Low doses of carbon disulfide upregulate NGF-R mRNA
expression in sciatic nerve. American Society for Neurochemistry Annual
Meeting, 1995.

Hong, H.L., Devereux, T.R., Boorman, G.A., and **Sills, R.C.**:
[Ras]{.underline} oncogene mutations in Harderian gland neoplasms of
B6C3F1 mice exposed to isoprene for 6 months. FASEB Meeting, 1995.

**Sills, R.C.**, Hong, H.L., Devereux, T.R., and Boorman, G.A.:
Increased frequency of K-[ras]{.underline} oncogene mutations in lung
neoplasms from female B6C3F1 mice exposed to ozone. Veterinary
Pathology, Vol. 31, No. 5, p. 480, 1994.

**Sills, R.C.**, Morgan, K.T., and Boorman, G.A.: Accessory nasal
structures in toxicologic pathology studies. Veterinary Pathology, Vol.
31, No. 5, p. 618, 1994.

**Sills, R.C.**, Hong, H.L., Boorman, G.A., and Devereux T.R.: Genetic
alterations in the K-[ras]{.underline} gene of lung neoplasms from
female B6C3F1 mice exposed to ozone for 24 or 30 months. [Invited
presentation]{.underline}, The Tenth Health Effects Institute Annual
Conference, Reston, Virginia, May 1994.

Herbert, R.A., **Sills, R.C.**, Hong, H.L., Hailey, J.R., and Boorman,
G.A.: Comparison of morphologic and genetic characteristics of
spontaneous and ozone-induced lung neoplasms in B6C3F1 mice exposed to
ozone for 24 or 30 months, Society of Toxicologic Pathologists,
Charleston, South Carolina, 1994.

Hong, H.L., **Sills, R.C.**, Greenwell, A., Boorman, G.A., and Devereux,
T.R.: Activation of the K-[ras]{.underline} protooncogene in mouse lung
tumors following ozone exposure. FASEB Meeting, 1994.

Greenwell, A., **Sills, R.**, Soderkvist, P., and Wiseman, R.:
Characterization of [p53]{.underline} mutations by immunohistochemistry,
single strand conformation analysis and DNA sequencing in B6C3F1 mice
exposed to 1,3,-Butadiene. SOT Annual Meeting, 1994.

**Sills, R.**, Greenwell, A., Marsman, D., Wiseman, R., Devereux, T.,
and Boorman, G.: Expression of [p53]{.underline} and PCNA in
chemically-induced neoplasms of B6C3F1 mice. Veterinary Pathology, Vol.
30, No. 5, p. 480, 1993.

**Sills, R.**, Dunnick, J., Hailey, R., and Elwell M.: Renal toxicity of
p-Nitrobenzoic acid in 13-week and 2-year feed studies in F344 rats.
Veterinary Pathology, Vol. 30, No. 5, p. 443, 1993.

Devereux, T.R., **Sills, R.C.**, Maronpot, R.R., and Anderson, M.W.:
Analysis of H-[ras]{.underline} mutations in hepatoblastomas which
appear to arise from hepatocellular carcinomas in B6C3F1 mice exposed to
oxazepam in the diet. Workshop on \" Histopathobiology of cancer\",
American Association for Cancer Research, Keystone, Colorado, 1993.

Wiseman, R., Cochran, C., Hegi, M., **Sills, R.**, Greenwell, A.,
Goodrow, T., Dietrich, W., Lander, E., and Soderkvist, P.: Oncogene
activation and tumor suppressor gene inactivation in butadiene-induced
tumors of B6C3F1 mice. Butadiene Meeting, Finland, April 1993.

**Sills, R.**, Dunnick, J., Elwell, M., and Eustis, S.: Gastrointestinal
toxicity of turmeric oleoresin in prechronic and chronic dose-feed
studies in Fischer 344 rats. Veterinary Pathology, Vol. 29, No. 5, p.
462, 1992.

**Sills, R.C.**, and Sleight, S. D.: Immunohistochemical detection of
[ras]{.underline} p21 protein and morphological evaluation of foci in
Sprague-Dawley rats during

hepatocarcinogenesis. American College of Veterinary Pathologists,
Phoenix, Arizona, 1990.

**Sills, R.C.**, and Sleight, S.D.: Immunohistochemical detection of the
oncogene product [ras]{.underline} p21 protein in preneoplastic and
neoplastic lesions during chemically induced hepatocarcinogenesis. 29th
Annual Meeting, Society of Toxicology, Miami, Florida, 1990.

Sleight, S.D., and **Sills, R.C.**: Effects of
2,3,7,8-tetrachlorodibenzo-p-dioxin on initiated weanling Sprague-Dawley
rats treated with phenobarbital. 29th Annual Meeting, Society of
Toxicology, Miami, Florida, 1990.

# INVITED COVERS FOR INTERNATIONAL JOURNALS

Toxicologic Pathology: p-Nitrobenzoic Acid Alpha 2μ Globulin
Nephropathy, Volume 29, No 5, 2001

Toxicologic Pathology: Mutations in butadiene-induced hemangiosarcomas,

Volume 28, No. 4, 2000

Toxicological Sciences: Atherosclerosis Studies, Volume 49, No. 1, 1999

NeuroToxicology: Carbon Disulfide Neurotoxicity Studies, Volume 19, No.
1, 1998

Toxicologic Pathology: Tumor Suppressor Gene Studies, Volume 26, No. 3,
1998

**[HONORS AND AWARDS SINCE AT NIEHS]{.underline}**

**• *NIH Directors Award*** -- In recognition of consistent dedication
and teamwork

insuring quality evaluation and interpretation of pathology aspects of
NTP studies --

2000

**• *NIEHS On-the-Spot Award*** *-* Electromagnetic Field Award (EMF) -
In recognition for diligence, efficiency and perseverance in validating
the accuracy of pathology data -essential efforts for NIEHS to complete
its report on EMF to Congress on time --1998

***• Bronze Medal for Commendable Service*** - Awarded by the United
States

Environmental Protection Agency for successfully conducting a large and
complex

collaborative neurotoxicity study --1997

**• *Department of Health and Human Services Public Health Service*
*On-The-Spot***

***Award*** - In recognition of efforts to lead, organize and
participate in NIEHS Diversity

Council, 1997

***• NIH Merit Award***, Division of Intramural Research - In
recognition of remarkably

successful efforts to characterize genetic alterations in oncogenes and
tumor

suppressor genes in NTP/NIEHS studies --1996

***• NIEHS On-the-Spot Award*** - Carbon Disulfide Collaborative Studies
-- 1994

**[OTHER HONORS AND AWARDS]{.underline}**

• Sigma Xi National Honorary Society -- 1991

• Outstanding Scientific Presentation Award: Oncogene Study in a

Hepatocarcinogenesis Model, Michigan Regional Chapter of the Society of
Toxicology -- 1990

• C.L. Davis Pathology Foundation Student Scholarship Award -- 1989

• Gamma Sigma Delta Honor Society - 1989

• Phi Zeta National Veterinary Honor Society - 1983

• Kleen Leen Swine Proficiency Award -- 1984

• Pfizer Veterinary Student Scholarship Award -- 1983

Adjunct Associate Professor, Faculty of the Curriculum in Toxicology,
The University of North Carolina at Chapel Hill, 2000-present.

Adjunct Associate Professor, Department of Microbiology, Pathology and

Parasitology, College of Veterinary Medicine, North Carolina State
University, 1999-present.

Advanced Toxicology Course 207, Graduate Students, University of North
Carolina,

1999-present.

Pathology 856 Current Concepts in Toxicologic Pathology, Graduate
Students,

Michigan State University, 1997, 1999, 2001.

Role of the Veterinary Pathologist in Industry, Government and Academia.
Summer Scholars Program. North Carolina State University, School of
Veterinary Medicine, 1993-1994.

**[NATIONAL COMMITTEES/CHAIRPERSON]{.underline}**

Society of Toxicologic Pathology Annual Meeting. The Human Genome:
Implications for Toxicologic Pathology and Carcinogenesis. [Invited
chairperson]{.underline}, Savannah, Georgia, June 2003.

Investigative Toxicology and Pathology Interest Group (ITPIG). Committee
of scientists from industry, academia and government which identifies
topics and issues for future ILSI seminars, STP and ACVP Meetings.
[Invited member]{.underline}, December 2002 - Present

International Life Sciences Institute (ILSI) Seminars on Advanced
Pathologic Techniques. Planning Committee. [Invited member]{.underline},
January 2002 - Present

American College of Veterinary Pathologists Recruitment Committee.
Addressing the need for attracting new talent to the profession.
[Invited member]{.underline}, November 2000 - Present.

Advisory Committee on Special Studies Relating to the Possible Long-Term
Health Effects of Phenoxy Herbicides and Contaminants, [Invited
Member]{.underline}, National Center for Toxicological Research, Food
and Drug Administration, 2000-Present.

**[NATIONAL COMMITTEES/CHAIRPERSON cont'd]{.underline}**

American College of Veterinary Pathologists 51^st^ Annual Meeting,
[Invited chairperson]{.underline}, Plenary Session -- Molecular and
Genetic Basis of Disease, Amelia Island, Florida, December 2000.

Society of Toxicologic Pathologists 18^th^ International Symposium,
[Invited chairperson,]{.underline}

Toxicologic Pathology of the Nervous System - Cellular and Molecular
Neuro-

carcinogenesis, Washington DC, 1999.

Advisory Committee on evaluating residues of veterinary drugs. Fiftieth
Meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA),
Rome, Italy, February 1998.

American College of Veterinary Pathologists, [Invited
chairperson]{.underline}, Molecular

Pathology, Toxicologic Pathology Specialty Group, Atlanta, November,
1995.

American College of Veterinary Pathologists, [Invited
co-chairperson]{.underline}, Toxicologic

Pathology Specialty Group, Montreal, Canada, October, 1994.

American College of Veterinary Pathologists and Society of Toxicologic
Pathologists

Joint Committee. Addressing the need for scholarships and training
programs in toxicologic pathology. [Invited member]{.underline},
November 1992 - 1996.

**[INTRAMURAL COMMITTEE/FACULTY/GROUP MEMBERSHIP]{.underline}**

Neuroscience Faculty, 2003-Present

Committee on Hiring, Tenure and Promotion (COP III), 2002 - Present

Gene Expression Committee, 1999-2001

Transgenic Mouse Models Faculty, 1999-2001

Committee on Hiring, Tenure and Promotion (COP II), 1997-2001

Molecular Oncology Faculty, 1995-2000

Intramural Research Awards Committee, 1995-2000

Assembly of Scientists Council, Secretary, 1998-1999

**[INTRAMURAL COMMITTEE/FACULTY/GROUP MEMBERSHIP cont'd.]{.underline}**

National Toxicology Program Archives Committee, Head, 1994-1997

Diversity Council, 1996-1997

Workplace Assessment Committee, 1997-1999

NIEHS Conference, Symposium, and Lecture Committee, NIEHS, October 1994
--

1996\.

# INTRAMURAL SEARCH COMMITTEES FOR NEW NIEHS SCIENTIFIC POSITIONS

Committee for biostatistician (National Toxicology Program), 2002-2003

Committee for branch chief, Laboratory of Molecular Carcinogenesis, 2002

Committee for staff scientist for epidemiologist, 2001-2002

Committee for staff scientist for molecular toxicologist, 2001-2002

Committee for staff scientist for developmental toxicology, 1999-2000

Committee for staff scientist for technology coordinator, 1999-2000

Committee for staff scientist for the report on carcinogens, 1999-2000

Committee for biostatistician (reproductive studies), 1999-2000

Committee for biostatistician (National Toxicology Program), 1999

Committee for staff scientist and toxicogenomics facilitator, 1999

Committee for molecular toxicology group leader, 1999

Committee for functional toxicology group leader, 1998

Committee for staff epidemiologist, 1998

Committee for staff scientist in exposure assessment, 1998

Committee for scientist in chromatin structure and gene regulation, 1997

**[PROFESSIONAL ASSOCIATIONS]{.underline}**

American Association for Cancer Research

American College of Veterinary Pathologists

Society of Toxicologic Pathologists

American Veterinary Medical Association

Society of Toxicology, North Carolina Chapter, (Served as Councilor)

# EDITORIAL REVIEW BOARD

Toxicologic Pathology, 1999-2002

Pathology of the Mouse, Reference and Atlas. Cache River Press, Vienna,
IL., 1999.

## [INVITED JOURNAL REVIEWER]{.underline} 

Molecular Carcinogenesis

Veterinary Pathology

Toxicological Sciences

Toxicology and Applied Pharmacology