**October, 2005**

[CURRICULUM VITAE]{.underline}

[Name]{.underline}: Iqbal Unnisa Ali, Ph.D.

[Citizenship]{.underline}: U.S.A.

[Education]{.underline}:

1971 M.S., Biochemistry, University of Tuebingen, Germany

1974 Ph.D., Biochemistry, Pharmacology and Microbiology, University of
Göttingen, Germany

[Brief Chronology of Employment:]{.underline}

1972-1974 Graduate Studies at Max-Planck, Institute, Göttingen, Germany

1974-1975 Post-doctoral fellow, ICIG, C.N.R.S., Villejuif, France and
Biocenter, University of Basel, Basel, Switzerland

1975-1978 Research Associate, Center for Cancer Research, MIT

1978-1989 Visiting Scientist, National Cancer Institute, NIH

1989-1994 Head, Molecular Biology Unit, Surgical Neurology Branch,
National Institute of Neurological Disorders and Stroke, Bethesda, MD

1994-1997 Special Expert, National Cancer Institute, NIH

1997-Date Division of Cancer Prevention, National Cancer Institute,
National Institutes of Health, Bethesda, MD

2003-2004 Adjunct Appointment, Laboratory of Genomic Diversity, Center
for Cancer Research, National Cancer Institute-Frederick, MD

2004-Date Adjunct appointment, Laboratory of Cancer Prevention, Center
for Cancer Research, National Cancer Institute-Frederick, MD

[Honors and Awards]{.underline}:

-   One of five students from Pakistan selected to receive the German
    Academic Award for Ph.D.

-   Ph.D. - University of Göttingen, Germany, Magna Cum Laude

-   Cited in Current Content (July 21, Vol. 23, 1980) as first author of
    a paper in Cell (Ref. #1 in Bibliography) which was one of the 100
    most cited papers in 1978 and 1979 and one of the three most cited
    papers in the field of cancer biology in 1978 and 1979

-   Sustained Superior Performance Awards in 1999, 2000, 2002, 2004, and
    2005.

    [Publications]{.underline}:

1.  Kuntzel, H., Barath Z., Ali, I.U., Kind J., Althaus, H.H.:
    Virus-like particles in an extracellular mutant of Neurospora
    crassa. *Proc. Natl. Acad. Sci. USA* 70: 1574, 1973.

2.  Kuntzel, H., Barath, Z., Ali, I.U., Kind ,J., Althaus, H.H.,
    Blossey, H.C.: Expression of the mitochondrial genome in wild type
    and in an extranuclear mutant of Neurospora crassa. In: Bautz EKF
    (ed), *Regulation of Transcription and Translation in Eukaryotes*,
    Heidelberg, Springer Verlag, pp. 195, 1973.

3.  Kuntzel, H., Ali, I.U., Blossey, H.C.: Expression of mitochondrial
    genome in wild type and in an extracellular mutant of Neurospora
    crassa. In: Kroon AM, Saccone C (eds.), *Proc Intern Conf on the
    Biogenesis of Mitochondria*, New York, Academic Press, 1973.

4.  \*Ali, I.U., Mautner, V., Lanza, R., Hynes, R.O.: Restoration of
    normal morphology, adhesion and cytoskeleton in transformed cells by
    addition of a transformation sensitive surface protein. *Cell* 11:
    115-126, 1977.

5.  Ali, I.U., Hynes, R.O.: Effects of cytochalasin B and colchicine on
    attachment of a major surface protein of fibroblasts. *Biochim.
    Biophys. Acta*. 471: 16-24, 1977.

6.  Ali, I.U., Hynes, R.O.: Role of disulfide bonds in the attachment
    and function of LETS glycoprotein at the cell surface. *Biochim.
    Biophys. Acta*. 510: 140-150, 1978.

7.  Ali, I.U., Hynes, R.O.: Effects of LETS glycoprotein on cell
    motility. *Cell* 14: 439-446, 1978.

8.  Hynes, R.O., Destree, A.T., Ali, I.U.: Synthesis, secretion and
    attachments of LETS glycoprotein in normal and transformed cells.
    *J. Supramol. Struct.* 7: 397-408, 1978.

9.  Hynes, R.O., Ali, I.U., Mautner, V., Destree, A.T.: LETS
    glycoprotein: Arrangement and function at the cell surface.
    *Molecular Basis of Cell-Cell Interactions.* New York, Alan Liss,
    Inc. 178: 139-153, 1978.

10. Hynes, R.O., Ali, I.U., Destree, A.T., Mautner, V., Perkins, M.E.,
    Senger, D.R., Wagner, D.D.: A large glycoprotein lost from the
    surface of transformed cells. *Ann. NY Acad. of Sci.* 312: 317-342,
    1978.

11. Ali, I.U., Hunter, T.: Structural comparison of fibronectins from
    normal and transformed cells. *J. Biol. Chem.* 256: 7671-7677, 1981.

12. Bassin, R., Ruscetti, S., Ali, I.U., Haspala, D., Rein, A.: Normal
    DBA/2 mouse cells synthesize a glycoprotein which interferes with
    MCF virus infection. *Virology* 123: 139-151, 1983.

13. Ali, I.U.: Phosphorylation of fibronectin in quiescent and growing
    cell cultures. *FEBS Letters* 151: 45-48, 1983.

14. Ali, I.U.: Structural analysis of fibronectin and its
    collagen-binding domain from several cell lines. *Proc. Natl. Acad.
    Sci. USA* 82: 28-32, 1984.

15. Ali, I.U.: Analysis of phosphorylation sites on fibronectin. *FEBS
    Letters* 176: 165-169, 1984.

16. Callahan, R., Ali, I.U., Fetherston, J., Horn, T., Schlom J.: Human
    endogenous retroviral genes and their possible role in oncogenesis.
    *Cell Tech.* 12: 1103-1108, 1984.

17. Callahan, R., Chiu, I., Horn, T., Ali, I.U., Robbins, J., Aaronson,
    S., Schlom J.: A new class of human retroviral genes. In: M. Rich
    (ed.), *RNA Tumor Viruses in Human Cancer,* pp. 76-92, 1985.

18. Callahan, R., Ali, I.U., Fetherston, J., Horn, T., Schlom, J.: The
    organization of mouse mammary related sequences in human cellular
    DNA. In: Varier OE, Gallo RC, Stehlin D (eds.), *Retroviruses and
    Human Genomic DNA*, 1985.

19. Fetherston, J.D., Toby, H., Mariani-Constantini, R., Ali, I.U.,
    Schlom, J., Callahan, R.: *Novel endogenous retroviral genomes in
    human genomic DNA*, 1985.

20. Feuerstein, N., Ali, I.U.: Comparative anaysis of p21 proteins from
    various cell types by two-dimensional gel electrophoresis. *J.
    Cellular Biochem*. 29: 253-263, 1985.

21. Ali, I.U., Rasheed, S.: Human normal and tumor cell lines:
    comparison of fibronectins and collagens. *Cancer Investigation* 5:
    17-24, 1987.

22. Ali, I.U., Lidereau, R., Theillet, D., Callahan, R.: Reduction to
    homozygosity of genes on chromosome 11 in human breast neoplasia.
    *Science* 238: 185-188, 1987.

23. Ali, I.U., Lidereau, R., Callahan, R.: Heterogeneity of genetic
    alterations in primary human breast tumors. In: *Breast Cancer:
    Cellular and Molecular Biology*. Lippman M and Dickson R (eds.), pp.
    25-48, 1988.

24. Lidereau, R., Callahan, R., Dickson, C., Peters, G., Escot, C., Ali,
    I.U.: Amplification of the int-2 gene in primary human breast
    tumors. *Oncogene Res*. 2: 285-291, 1988.

25. Senger, D.R., Perruzzi, C.A., Ali, I.U.: T24 human bladder carcinoma
    cells with activated Ha-ras proto-oncogene: Non-tumorigenic cells
    susceptible to malignant transformation with carcinogen. *Proc.
    Natl. Acad. Sci. USA*. 85: 5107-5111, 1988.

26. Ali, I.U., Campbell, G., Lidereau, R., Callahan, R.: Amplification
    of c-erb B2 and aggressive human breast tumors. *Science* 240:
    1795-1796, 1988.

27. Ali, I.U., Campbell, G., Lidereau, R., Callahan, R.: Lack of
    evidence for the prognostic significance of c-erb-B2 amplification
    in human breast carcinoma. *Oncogene Res*. 3: 139-146, 1988.

28. Lidereau, R., Mathieu-Mahul, D., Escot, C., Theillet, C., Champeme,
    M.H., Cole, S., Maushaffe, M., Ali, I.U., Amione, J., Callahan, R.,
    Larson, C.J.: Genetic variability of proto-oncogenes for breast
    cancer risk and prognosis. *Biochem.* 70: 951-959, 1988.

29. Ali, I.U., Merlo, G., Callahan, R., Lidereau, R.: Amplification unit
    on chromosome 11q13 in aggressive primary human breast tumor entails
    bc1-1, int-2 and hst loci. *Oncogene* 4: 890-892, 1989.

30. Ali, I.U., Campbell, G., Merlo, G., Smith, G., Callahan, R.,
    Lidereau, R.: Multiple genetic alterations in human breast cancer
    and their possible prognostic significance. Cancer Cell. Cold Spring
    Harbor Laboratory, Vol. 7, pp. 399-403, 1989.

31. Ali, I.U., Lidereau, R., Callahan, R.: Presence of two members of
    c-erbA receptor gene family (c-erbAB and c-erbA2) in smallest region
    of somatic homozygosity on chromosome 3-p21-p25 in human breast
    carcinoma. *J. Natl. Cancer Inst*. 81: 1815-1820, 1989.

32. Ali, I.U., Callahan, R.: Prognostic significance of genetic
    alterations in human breast neoplasia. In: *Molecular Genetic and
    the Diagnostics of Cancer*, Cossman J (ed.), Elsevier Science
    Publishing, pp. 289-311, 1990.

33. Thor, A., Solomon, D., Merlo, G., Liscia, D., Lidereau, R., Schlom,
    J., Callahan, R., Ali, I.U.: *Breast Carcinoma and Oncogenes: An
    Update*, Martinus Nijhoff Publishing, 1991.

34. Schulte, H.M., Oldfield, E.H., Allolio, B., Katz, D.A., Ali, I.U.:
    Clonal composition of pituitary adenomas in patients with Cushing\'s
    disease. Determination by x-chromosome inactivation analysis. *J.
    Clinical End. Met*. 73: 1302-1308, 1991.

35. Saxena, A. and Ali, I.U.: Increased Expression of genes from growth
    factors signaling pathways in glioblastoma cell lines. *Oncogene* 7:
    520-525, 1992.

36. Berkman, R., Clark, C., Saxena, A., Robertson.J, Oldfield, O.H.,
    Ali, I.U.: Clonal composition of glioblastoma multiforme. *J.
    Neurosurg*. 77: 432-437, 1992.

37. Flemming T, Saxena, A., Clark C, Robertson, J.T, Oldfield, O.H.,
    Aaronson, S., Ali, I.U.: Amplification and/or overexpression of
    platelet-derived growth factor receptors and epidermal growth factor
    receptor in human glial tumors. *Cancer Res.* 52: 4550-4553, 1992.

38. Ali, I.U., Reinhold, W., Salvador, C., Aguanno, S.: Aberrant
    splicing of alpha subunit of Gs transcript in transformed human
    astroglial and glioblastoma cell lines. *Nucleic Acids Res.* 20:
    4263-4267, 1992.

39. Saxena, A., Clark, C., Robertson, J., Ikejiri, B., Oldfield, E.H.,
    Ali, I.U.: Evidence for the involvement of a potential second tumor
    suppressor gene on chromosome 17 distinct from p53 in malignant
    astrocytomas. *Cancer Res.* 52: 6716-6721, 1992.

40. Berkman, R.A., Merrill, M.J., Monacci, W.T., Saxena, A., Clark,
    W.C., Robertson, J.T, Ali, I.U., Oldfield, O.H.: Vascular
    permeability factor/Vascular endothelial growth factor in human
    central nervous system neoplasms. *J. Clin. Inves.* 91: 153-159,
    1993.

41. Moenig, H., Ali, I.U., Oldfield, O.H., Schulte, H.: Structure of the
    POMC promoter region in pituitary and extrapituitary ACTH-producing
    tumors. *Exp. Clin. Endocrinol.* 101: 36-38, 1993.

42. Ali, I.U., Saxena, A., Meissner, S., Barrick, J., Lidereau, R.:
    Close proximity of c-erbA2 and c-erbA genes on the short arm of
    chromosome 3. *Oncogene* 8: 2299-2301, 1993.

43. Ali, I.U., Schweitzer, J., Saxena, A., Ikejiri, I., Robertson, J.T,
    Oldfield E: Heterogeneity of the subcellular localization of the p53
    protein in human glioblastomas. *Cancer Res.* 54: 1-5, 1994.

44. Piccirilli, C.B., Saxena, A., Robertson, J.T, Clark, W.C., Ikejiri,
    B., Oldfield, O.H., Ali, I.U.: Allelic deletions on chromosome 17p
    and/or mutations in the p53 gene in tumors metastatic to brain.
    *Int. J. Oncol*. 4: 37-42, 1994.

45. Saxena, A., Robertson, J.T, Kufta, C., Stetler-Stevenson, W., Ali,
    I.U.: Increased expression of gelatinase A and TIMP-2 in primary
    human glioblastomas. *Int. J. Oncol*. 7: 469-473, 1995.

46. Karl, M., Wichert, G.V., Kempter, E., Katz, D.A., Reincke, M.,
    Moenig, H., Ali, I.U., Stratakis CA, Oldfield, O.H., Chrousos GP,
    Schulte HM: Nelson\'s syndrome associated with a somatic frame shift
    mutation in the glucocorticoid receptor gene. *J. Clinical End.
    Met.* 81: 124-129, 1996.

47. Saxena, A., Robertson, J.T, Ali, I.U.: Abnormalities of *p16*,
    *p15*, and *CDK4* genes in recurrent glioblastomas. *Oncogene* 13:
    661-664, 1996.

48. Saxena, A., Robertson, J.T, Schweitzer, J., Ali, I.U.: Prognostic
    significance of genetic lesions on chromosomes 19, 10, and 17 in
    oligodendrogliomas/oligoastrocytomas. *Int. J. Oncol.* 9: 901-905,
    1996.

49. Saxena, A., Shriml, L., Dean, M., Ali, I.U.: Comparative molecular
    genetic profiles of anaplastic astrocytomas/glioblastomas multiforme
    and their subsequent recurrences. *Oncogene* 18: 1385-1390, 1999.

50. Ali, I.U., Shriml, L., Dean, M.: PTEN/MMAC1, A phosphatase with
    tumor suppressor function: mutational spectra in the germline and in
    human cancers. *J. Natl. Cancer Inst*. 91: 1922-1932, 1999.

51. Ali, I.U.: Molecular genetics of human cancer: state-of-the-art
    diagnostic and therapeutic approaches. *Pak. J. Pharmcol.* 16:
    57-72, 1999.

52. Kelloff, G.J., Crowell JA, Steele VE, Lubet RA, Boone CW, Malone WA,
    Hawk ET, Lieberman R, Lawrence JA, Kopelovich L, Ali I, Viner JL,
    Sigman CC: Progress in cancer chemoprevention. *Ann. NY Acad. Sci.*
    889: 1-13, 1999.

53. Kelloff, G.J., Crowell, J.A., Steele, V.E., Lubet, R.A., Malone,
    W.A., Boone, C.W., Kopelovich, L., Hawk, E.T., Lieberman, R.,
    Lawrence, J.A., Ali, I., Viner, J.L., Sigman, C.C.: Progress in
    cancer chemoprevention: development of diet-derived chemopreventive
    agents. *J. Nutr.* 130: 467S-471S, 2000.

54. Ali, I.U.: Gatekeeper for endometrium: the PTEN tumor suppressor
    gene. *J. Natl. Cancer Inst.* 92: 861-863, 2000.

55. Herbert, B.S., Wright, A.C., Passons, C.M., Wright, W.E., Ali, I.U.,
    Kopeolvich, L., Shay, J.W.: Effects of chemopreventive and
    antitelomerase agents on the spontaneous immortalization of breast
    epithelial cells. *J. Natl. Cancer Inst.* 93: 39-45, 2001.

56. Ali, I.U., Senger, D., Smith, L.: Angiogenesis as a potential
    biomarker in prostate cancer chemoprevention trials. *Urol.* 57:
    143-147, 2001.

57. Ali, I.U.: Angiogenesis: a promising target for cancer prevention.
    (invited chapter) *Handbook. Exp. Pharm. on Mechanisms in
    Carcinogenesis and Cancer Prevention*, pp. 101-117, 2002.

58. Calvo, A., Smith, L.E., Ali, I.U., Shih, S-C., Yokoyama, Y.,
    Sundaram, R., Feldman, A.L., Libutti, S.K., Green, J.E.: Inhibition
    of mammary gland adenocarcinoma angiogenic switch in C3(1)SV40
    transgenic mice by a mutated form of human endostatin. *Intl. J.
    Cancer* 101: 224-234, 2002.

59. Shih, S-C., Robinson, G.S., Perruzzi,, C.A., Calvo, A., Desai, K.,
    Green, J.E., Ali, I.U., Smith, L.E., Senger, D.: Molecular profiling
    of angiogenesis markers. Am J Pathol. 161: 35-41, 2002.

60. Hakim, I.A., Harris, R.B., Chow, H-HS., Dean, M., Brown, S., Ali,
    I.U.: Effect of a 4-month tea intervention on oxidative DNA damage
    among heavy smokers: role of glutathione s-transferase genotypes.
    *Cancer Epidemiol. Biomarkers Prev.* 13: 242-249, 2004.

61. Xiao, Z., Luke, B.T., Izmirlian, G., Umar, A., Lynch, P.M.,
    Phillips, R.K.S., Patterson, S., Conrads, T.P., Veenstra, T.D.,
    Greenwald, P., Hawk, E.T., Ali, I.U.: Serum proteomic profiles
    suggest celecoxib-modulated targets and response predictors. *Cancer
    Res.* 64: 2904-2909, 2004.

62. Hakim, I.A., Dean, M., Harris, R.B., Ali, I.U.: Effect of a 4-month
    tea intervention on oxidative DNA damage among heavy smokers: role
    of XRCC1 genotypes. *Evidence-Based Prev. Med.* 2: 93-99, 2004.

63. Hakim, I.A., Ali, I.U.: hOGG1 genotype, green tea and oxidative DNA
    damage among heavy smokers. *Evidence-Based Integrative Medicine*.
    1: 245-251, 2004.

    [Manuscripts In Press or Submitted]{.underline}:

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1.  Ali, I.U., et al.: Allelic variants in regulatory regions of
    cyclooxygenase 2: Association with advanced colorectal adenoma.
    *Brit J Cancer*, in press.

2.  Luke, B.T., Xiao, Z., Ali I.U.: Identification of serum proteomic
    markers as response predictors for celecoxib: application of
    multiple classification algorithms. *Proteomics*, Submitted.

3.  Ali, I.U., Xiao, Z., Malone, W., Smith, M., Conrads, T.P., Veenstra,
    T.D., Greenwald, P., Luke, B.T., McLarty, J. W.: Plasma proteomic
    profiling: Search for lung cancer diagnostic and early detection
    markers. *Int J Mol Med.* Submitted.