# Publications

1.  Jen, J., Deschepper, C.F., Shackleford, G.M., Lee, C-Y.G., and Lau,
    Y-F.C. Stage-specific expression of the lactate dehydrogenase-X gene
    in adult and developing mouse testes.*Molecular Reproduction and
    Development* 25:14-21, 1990.

2.  Mitchell, D.L., [Jen, J.,]{.underline} and Cleaver, J.E. Relative
    induction of cyclobutane dimers and cytosine photohydrates in DNA
    irradiated in vitro and in vivo with ultraviolet-C and ultraviolet-B
    light. *Photochemistry and Photobiology* 54:741-746, 1991.

3.  Mitchell, D.L., Jen, J., and Cleaver, J.E. Sequence specificity of
    cyclobutane pyrimidine dimers in DNA treated with solar
    (ultraviolet B) radiation. *Nucleic Acid Research* 20:225-229, 1992.

4.  Powell, S.M., Petersen, G.M., Krush, A.J., Booker, S., Jen, J.,
    Giardiello, F.M., Hamilton,S.R., Vogelstein, B., and Kinzler, K.W.
    Molecular diagnosis of familial adenomatous polyposis. *New England
    Journal of Medicine* 329: 1982-1987, 1993.

5.  Parsons, R., Li, G-M., Longley, M.J., Fang, W-H., Papadopoulos, N.,
    Jen, J., de la Chapelle, A., Kinzler, K.W., Vogelstein B., and
    Modrich, P. Hypermutability and Mismatch Repair Deficiency in RER+
    Tumor Cells. *Cell* 75: 1227-1236, 1993.

6.  Leach, F.S., Nicolaides, N.C., Papadopoulos, N., Liu, B., Jen, J.,
    Parsons, R., et al., Mutations of a mutS homolog in hereditary
    nonpolyposis colorectal cancer. *Cell* 75: 1215-1225, 1993.

7.  Kim, H., Jen, J**[.]{.underline}**, Vogelstein, B., and Hamilton,
    S.R. Clinical and Pathological Characteristics of Sporadic
    Colorectal Carcinomas with DNA Replication Errors in Microsatellite
    Sequences. *American Journal of Pathology* 145: 148-156, 1994.

8.  Jen, J., Powell, S.M., Papadopoulos, N., Smith, K.J., Hamilton,
    S.R., Vogelstein, B., and Kinzler, K.W. Molecular Determinants of
    Dysplasia in Colorectal Lesions. *Cancer Research* 54: 5523-5526,
    1994.

9.  Jen, J., Kim, H., Piantadosi, S., Liu, Z-F., Levitt, R.C., Sistonen,
    P., Kinzler, K.W., Vogelstein, B., and Hamilton, S.R. Allelic loss
    of chromosome 18q and prognosis in colorectal cancer. *New England
    Journal of Medicine* 331: 213-221, 1994.

10. Jen, J., Harper, J.W., Bigner, S.H., Bigner, D.D., Papadopoulos, N.,
    Markowitz, S., Willson, J.K.V., Kinzler, K.W., and Vogelstein, B.
    Deletion of *p16* and *p15* Genes in Brain Tumors. *Cancer Research*
    54: 6353-6358, 1994.

11. Liu, B., Nicolaides, N.C., Markowitz, S., Willson, J.K.V., Parsons,
    R.E., Jen, J., Papadopolous, N., Peltomaki, P., de la Chapelle, A.,
    Hamilton, S.R., Kinzler, K.W., and Vogelstein, B. Mismatch repair
    gene defects in sporadic colorectal cancers with microsatellite
    instability. *Nature Genetics* 9:48-55, 1995.

12. Herman J.G., Jen, J., Merlo, A., and Baylin, S.B.
    Hypermethylation-associated inactivation indicates a tumor
    suppressor role for *p15*^INK4B1.^ *Cancer Research* 56,722-727,
    1996.

13. Da Costa, L., Jen J., He, T.C., Kinzler, K.W., and Vogelstein, B.
    Converting cancer genes into killer genes.*Procedings of the
    National Academy of Sciences.* 93*:4192-4196,* 1996

14. Jen, J., Mitchell, D.L., Cunningham, R.P., Smith, C.A., Taylor, J.S.
    and Cleaver, J.E. Ultraviolet irradiation produces a novel
    endonuclease III-sensitive cytosine photoproducts at dipyrimidine
    sites. *Photochem Photobio* 65(2):323-329, 1997.

15. Okami, K., Cairin P, Westra, W., Linn J, Ahrent, SA., Wu, L,
    Sidransky, D, and Jen, J Detailed deletion mapping at chromosome
    9p21 in Non-small cell lung cancer by microsatellite analysis and
    fluorescence in situ hybridization. *International Journal of
    Cancer* 74,1-5 (1997).

16. Okami, K., Wu, L., Riggins, G., Cairns, P., Goggins, M., Evron, E.,
    Halachmi, N., Ahrendt, S., Reed, A., Hilgers, W., Kern, S.,
    Sidransky, D. and Jen, J. Analysis of PTEN/MMAC1 alterations in
    aerodigestive tract tumors. *Cancer Research*. 58:509-511, 1998.

17. Hibi., K., Robinson, R., Booker, S., Wu, L., Hamilton, S.R.,
    Sidransky, D., and Jen, J. Molecular detection of genetic
    alterations in the serum of colorectal cancer patients. *Cancer
    Research*. 58:1405-1407, 1998.

18. Leong, P., Banafsheh, R., Reed, A., Koch, W., Lee, D., Sidransky,
    D., Jen, J., Westra, W.H. Distinguishing second primary tumors from
    metastases in patients with head and neck squamous cell carcinoma.
    *Journal of National Cancer Institute*. 90, 972-7(1998).

19. Trink, b., Okami, K., Wu, L., Sriuranpong, V., Jen, J., and
    Sidransky, D. A new human p53 homologue. *Nature medicine*. 4,3-4
    (1998).

20. Hibi, K., Liu, Q., Westra, W., Wehage, S., Borges, M., Yang, S.,
    Heitmiller, R., Sidransky, D., Jen, J. Serial analysis of genes
    overexpressed in non-small cell lung cancer. *Cancer Research*
    58,5690-94 (1998).

21. Jen, J., Johnson, C. and Levin, B. Molecular approaches for
    colorectal cancer screening. E*uropean Journal of Gastroenterology
    and Hepatology.* 10, 213-217,1998*.*

22. Ahrendt, S.A., Halachmi, S., Chow, J.T., Wu, L., Halachmi, N.,
    Wehage, S., Jen, J., Sidransky, D. Rapid p53 sequence analysis using
    an oligonucleotide probe array in primary lung cancer. *Proc Natl
    Acad Sci* 96:7382-7 (1999).

23. Sanchez-Cespedes M, Reed AL, Buta M, Wu L, Westra WH, Herman JG,
    Yang SC, Jen J, Sidransky D. Inactivation of the INK4A/ARF locus
    frequently coexists with TP53 mutations in non-small cell lung
    cancer. *Oncogene* 18(43):5843-9(1999).

24. Hibi K, Westra WH, Borges M, Goodman S, Sidransky D, Jen J. PGP9.5
    as a candidate tumor marker for non-small-cell lung cancer. *Am J
    Pathol* 155:711-5 (1999)

25. Yamaguchi, K., Wu, L., Hibi, K., Trink, B., Cairns, P., Okami, K.,
    Sidransky, D., and Jen, J. Frequent gain of the p40/p51/p63 gene
    locus in primary HNSCC*. Int. J. Cancer* 86(5):684-9 (2000).

26. Ahrendt, S.A., Decker, A.D., Doffek, K., Wang, B., Xu, L.H.,
    Demeure, M.J., Jen, J., and Sidransky, D. Microsatellite instability
    at selected tetranucleotide repeats is associated with p53 mutations
    in non-small cell lung cancer. *Cancer Res.* 60(9):2488-91 (2000).

27. Makiko, S.F., Usadel, H., Caballero, O.L., Wu, L., Buta, M., Westra,
    W., Eleff, S., Jen, J., and Sidransky D. Facile detection of
    humoplasmic mitochondrial DNA mutations in primary tumors and bodily
    fluids. *Science* 287:2017-9 (2000).

28. Jen, J. Microsatellite analysis to assess chromosome 18q status in
    colorectal cancer. *Methods in Molecular Medicine* Powell, S (Ed*)
    Humanna Press* (2000)

29. Xu, L-H, Chow, J., Eisenberger, C., Bonacum, J., Ahrendt, S., Reed,
    A., Spafford, M., Westra, W.H, Yang, S., Sheng M. L, Piantadosi, S.,
    Tockman, M., Sidransky, D., Jen, J., Microsatellite Instability at
    (AAAG) Repeat Sequences in Upper Aerodigestive Tract Cancers *Int J
    Cancer* 91(2):200-5 (2001)

30. Sanchez-Cespedes M, Ahrendt SA, Piantadosi, S., Rosell R., Monzo,
    M., Wu., Li., Westra, WH., Yang, SC., Jen, J., and Sidransky, D.
    Chromosomal alterations in lung adenoma from smokers and nonsmokers.
    *Cancer Res* 61(4):1309-13 (2001)

31. Rosas SL, Koch W, da Costa Carvalho MG, Wu L, Califano J, Westra W,
    Jen J, Sidransky D. Promoter hypermethylation patterns of p16,
    O6-methylguanine-DNA-methyltransferase, and death-associated protein
    kinase in tumors and saliva of head and neck cancer patients.
    *Cancer Res* 61(3):939-42 (2001)

32. Caballero, OL., Cohen, d., Liu Q., Esteller, M., Bonacum, J., White,
    P., Yochem, R., Herman, J., Westra, WH., Lengauer, C., Sidransky,
    D., and Jen J. Loss of chromosome 3p, 9p, and inactivation of
    p16INK4a in normal epithelium of patients with primary lung cancer.
    *Genes Chromosomes and Cancer* 32(2):119-25 (2001)

33. Dong, SM., Traverso, G., Johnson, C., Geng, L., Favis, R., Boynton,
    K., Hibi, K., goodman, S., D'Allessio, M., Paty, P., Hamilton, S.,
    Sidransky, D., Barany, F., Levin, B., Shuber, A., Kinzler, KW.,
    Vogelstein, B., and Jen, J. Detecting colorectal cancer in stool
    using multiple genetic targets. *Journal of National Cancer
    Institute* 93(11):798-9 (2001).

34. Rosas, S.L.B., Caballero, O.L., Carvalho, M.G.C., Sidransky, D.,
    Jen, J. Methylation Status in the Promoter Region of the Human
    PGP9.5 Gene in Cancer and Normal Tissue. Cancer Letters. 170(1):73-9
    (2001)

35. Nacht M, Dracheva T, Gao YH, Fujii T, Chen YD, Player A, Akmaev V,
    Cook B, Dufault M, Zhang M, Zhang M, Guo MZ, Curran J, Han S,
    Sidransky D, Betow K, Madden SL, and Jen J. Molecular
    Characteristics of Non-Small Cell Lung Cancer. *Proc. Nat. Acad.
    Science* (In press, 2001)

36. Caballero, OL. Resto, V., Patturajan, M., Guo, MZ., Engles, J.,
    Yochem, R., Ratoviski, E., Matunis, M., Sidransky, D., and Jen J.
    Interaction and colocalization of PGP9.5 with JAB1 and P27^kip1^.
    Oncogene. Submitted. 2001.