# SECTION C - DESCRIPTION/SPECIFICATION/WORK STATEMENT {#section-c---descriptionspecificationwork-statement .unnumbered}

**Table of Contents:**

[SECTION C - DESCRIPTION/SPECIFICATION/WORK STATEMENT
1](#section-c---descriptionspecificationwork-statement)

[1. Part 1: Bioastronautics Core Capabilities (Core)
5](#part-1-bioastronautics-core-capabilities-core)

[1.1 Baseline Operational Readiness 5](#baseline-operational-readiness)

[1.1.1 Operational facilities and laboratories
5](#operational-facilities-and-laboratories)

[1.1.2 Scheduling and Capacity 6](#scheduling-and-capacity)

[1.1.3 Assigning Costs 7](#assigning-costs)

[1.1.4 Annual Assessment of the Baseline Operational Readiness
7](#annual-assessment-of-the-baseline-operational-readiness)

[1.2 Contract Management and Administration
7](#contract-management-and-administration)

[1.2.1 Contract Management 7](#contract-management)

[1.2.2 Safety and Health 8](#safety-and-health)

[1.2.3 Quality Management System (QMS)
8](#quality-management-system-qms)

[1.2.4 Environmental Management System (EMS)
9](#environmental-management-system-ems)

[1.2.5 Safety, Reliability, Maintainability, and Quality Assurance
(SRM&QA)
11](#safety-reliability-maintainability-and-quality-assurance-srmqa)

[1.2.6 Earned Value Management System (EVMS)
13](#earned-value-management-system-evms)

[1.2.7 Cost estimating for IDIQ and LOE Tasks
14](#cost-estimating-for-idiq-and-loe-tasks)

[1.2.8 Financial Reporting 14](#financial-reporting)

[1.2.9 Facilities and Equipment Management
14](#facilities-and-equipment-management)

[1.2.10 Management and Security of Information Technology (IT)
15](#management-and-security-of-information-technology-it)

[1.2.11 Direct Administrative Support
17](#direct-administrative-support)

[1.2.12 Communicating, reporting, and metrics
17](#communicating-reporting-and-metrics)

[2 Part 2: Bioastronautics Operations, Research, and Flight Hardware
18](#part-2-bioastronautics-operations-research-and-flight-hardware)

[2.1 Habitability and Environmental Factors
18](#habitability-and-environmental-factors)

[2.1.1 General 19](#general)

[2.1.2 Habitability and Human Factors
20](#habitability-and-human-factors)

[2.1.2.1 Hardware Requirements Development and Verification
20](#hardware-requirements-development-and-verification)

[2.1.2.2 Space Food Systems 20](#space-food-systems)

[2.1.3 Environmental Factors 20](#environmental-factors)

[2.1.3.1 Acoustics 20](#acoustics)

[2.1.3.2 Microbiology 20](#microbiology)

[2.1.3.3 Radiation 21](#radiation)

[2.1.3.4 Toxicology 21](#toxicology)

[2.1.3.5 Water Quality 21](#water-quality)

[2.1.3.6 Advanced Technologies 22](#advanced-technologies)

[2.2 Human Adaptation and Countermeasures
23](#human-adaptation-and-countermeasures)

[2.2.1 Human Space Flight Missions 23](#human-space-flight-missions)

[2.2.2 Research on Human Adaptation and Countermeasures
24](#research-on-human-adaptation-and-countermeasures)

[2.2.3 Countermeasures Evaluation & Validation Project (CEVP)
24](#countermeasures-evaluation-validation-project-cevp)

[2.2.4 Exercise Countermeasures Project (ECP)
24](#exercise-countermeasures-project-ecp)

[2.2.5 Pre-breathe Reduction Protocol Project
25](#pre-breathe-reduction-protocol-project)

[2.2.6 Artificial Gravity Project (AG)
25](#artificial-gravity-project-ag)

[2.2.7 Laboratories 25](#laboratories)

[2.2.7.1 Bone & Mineral 26](#bone-mineral)

[2.2.7.2 Cardiovascular 26](#cardiovascular)

[2.2.7.3 Cellular & Molecular Research 26](#cellular-molecular-research)

[2.2.7.4 Environmental Biophysics 27](#environmental-biophysics)

[2.2.7.5 Exercise Physiology Laboratory
27](#exercise-physiology-laboratory)

[2.2.7.6 Muscle 27](#muscle)

[2.2.7.7 Neuroscience Laboratories 27](#neuroscience-laboratories)

[2.2.7.8 Nutritional Biochemistry 28](#nutritional-biochemistry)

[2.2.7.9 Pharmacology 28](#pharmacology)

[2.2.7.10 Psychology & Behavior 28](#psychology-behavior)

[2.2.7.11 Test Subject Facility & KC-135 Program Coordination
29](#test-subject-facility-kc-135-program-coordination)

[2.3 Space Medicine and Health Care Systems
30](#space-medicine-and-health-care-systems)

[2.3.1 Medical Operations 30](#medical-operations)

[2.3.2 Flight Medicine Clinic 30](#flight-medicine-clinic)

[2.3.3 Astronaut Medical Selection 31](#astronaut-medical-selection)

[2.3.4 Behavioral Sciences 31](#behavioral-sciences)

[2.3.5 Medical Informatics and Health Care Systems
32](#medical-informatics-and-health-care-systems)

[2.3.6 Space Medicine Equipment Requirements Definition
32](#space-medicine-equipment-requirements-definition)

[2.4 Biological Systems 33](#biological-systems)

[2.4.1 General 33](#general-1)

[2.4.2 Technology Management 34](#technology-management)

[2.4.3 Biological Systems Laboratories
34](#biological-systems-laboratories)

[2.4.4 Biotechnology Facility (BTF) Project
35](#biotechnology-facility-btf-project)

[2.4.5 Flight Definition Laboratory 35](#flight-definition-laboratory)

[2.4.6 Integration Project 35](#integration-project)

[2.4.7 Sensors and Controls Technology Development (SCTD)
37](#sensors-and-controls-technology-development-sctd)

[2.4.8 Outreach and Education 38](#outreach-and-education)

[2.4.9 Bioreactor Research Support (BRS) Project
38](#bioreactor-research-support-brs-project)

[2.5 Mission and Project Management and Program Integration
40](#mission-and-project-management-and-program-integration)

[2.5.1 Mission Management 40](#mission-management)

[2.5.2 Project management 41](#project-management)

[2.5.3 Shuttle and Station Flight Operations Support
42](#shuttle-and-station-flight-operations-support)

[2.5.4 Science Management and Technology Integration
42](#science-management-and-technology-integration)

[2.6 Bioastronautics Flight Hardware (BFH)
44](#bioastronautics-flight-hardware-bfh)

[2.6.1 Types of projects and products
45](#types-of-projects-and-products)

[2.6.2 Use of Off-The-Shelf Hardware 47](#use-of-off-the-shelf-hardware)

[2.6.3 Applicable Documents for Bioastronautics Flight Hardware
47](#applicable-documents-for-bioastronautics-flight-hardware)

[2.6.4 Sources for Reference Processes for Bioastronautics Flight
Hardware
48](#sources-for-reference-processes-for-bioastronautics-flight-hardware)

[2.6.5 BFH Safety, Reliability, Maintainability, and Quality Assurance
(SRM&QA)
48](#bfh-safety-reliability-maintainability-and-quality-assurance-srmqa)

[List of Acronyms: 51](#list-of-acronyms)

**Statement of Work for the Bioastronautics Contract**

Introduction

The Bioastronautics Contract is a long term, integrated contract for
support of the broad range of activities in the Office of
Bioastronautics in the Space and Life Sciences organization at the
Johnson Space Center. The Office of Bioastronautics is responsible for
the health and productivity of crews living and working in space, for
the overall excellence of science on human space missions, and for the
transfer of new knowledge to practical applications on Earth.

The mission of the Space and Life Sciences Directorate is to be the
world\'s leader in understanding the space frontier and the
opportunities, capabilities, and limitations of humans living and
working on that frontier. We will develop and implement systems to
enable the opportunities and reduce the barriers to human achievement in
space and on other planet bodies. We will accomplish our mission through
a combination of fundamental and applied research in space and life
science disciplines, our participation in space flight projects, and the
advancement and use of new technology. We will contribute to important
national goals by transferring our technology to other users and by
strengthening the educational applications of our knowledge, experience,
and vision.

To reach our long-term goals and accomplish our near-term objectives, we
use highly skilled personnel, utilize unique facilities, conduct space
flight experiments, contribute new techniques, and combine our
experience to advance the expansion of human activities in space. Our
personnel and capabilities contribute directly to the successful
operation of space flight activities.

The work includes fundamental and applied biomedical research;
biotechnology development; operational space medicine; clinical
laboratories; behavioral sciences; human factors engineering; spacecraft
environment monitoring and management; space food laboratory; biomedical
engineering; biomedical flight hardware requirements, design,
fabrication, and testing; payload and hardware integration with Shuttle
and the International Space Station; and space flight operations.

The National Space Biomedical Research Institute (NSBRI) is an active
partner with the Johnson Space Center in achieving the Bioastronautics
mission. The Institute is a consortium of internationally known
biomedical research institutions. Baylor College of Medicine, Houston,
Texas, is the sponsoring organization for the Institute. The Institute
and the Johnson Space Center operate under a Cooperative Agreement.

The Bioastronautics Critical Path Roadmap (BCPR) forms a major part of
the foundation of the Bioastronautics program. The Office of
Bioastronautics and the NSBRI collaborate closely on the BCPR. The BCPR
identifies and assesses more than fifty risks to human space flight and
identifies strategies to mitigate or eliminate those risks with short-,
medium-, and long-term research. While there are additional goals and
objectives of the Office of Bioastronautics, the BCPR carries
significant influence on the course of research and operations at JSC.

**Overview of the Bioastronautics Contract**

The Bioastronautics Contract is defined in two parts.

The contractor shall balance, coordinate, and manage Parts 1 and 2 to
produce the highest levels of effectiveness and efficiency for the
overall contract.

Part 1: Bioastronautics Core Capabilities

Part 1 is performed as a completion based effort and is provided for the
duration of the contract.

Part 1 defines the scope for maintaining a baseline operational
readiness of Bioastronautics facilities and laboratories and provides
contract-wide management and administrative functions. Part 1 covers
contractor management for government furnished Bioastronautics
facilities and laboratories as well as for supplemental Bioastronautics
facilities and laboratories provided by the contractor. Part 1 tasks
form the foundational infrastructure for Part 2 tasks.

Part 2: Bioastronautics Research, Operations, and Flight Hardware

Work under Part 2 of the SOW is performed through the issuance of
Indefinite Delivery Indefinite Quantity (IDIQ) and Level of Effort (LOE)
task and delivery orders. Task and delivery orders may be either cost
reimbursable or fixed price. They may be authorized at any time during
the contract.

Part 2 provides scope for medical services, research, technology
development, engineering, operations support, and flight hardware for
the discipline areas of the JSC Office of Bioastronautics. Task and
delivery orders issued under Part 2 define the work to be performed
within the scope of the SOW.

**Changes in the Scope of Bioastronautics Responsibilities**

The Office of Bioastronautics operates in a dynamic national and agency
environment. The Government has the discretion to transition some
portions of the activities described herein to other contracts to
accommodate changing agency goals and missions.

**Description of the Performance Requirements**

# Part 1: Bioastronautics Core Capabilities (Core)

The contractor shall provide a set of core capabilities (Core) for the
Bioastronautics Contract. Broadly defined, the Core consists of
capabilities that must be in place for the Bioastronautics program to
accomplish work through the Bioastronautics Contract on any given day.
The Core described in Part 1 provides the foundational infrastructure
for the IDIQ and LOE task and delivery orders that describe and
authorize specific activities and products from the scope of work
described in Part 2.

The Core is described in 2 sections.

-   The Baseline Operational Readiness section defines the concept of
    baseline operational readiness and describes the general
    requirements for operational readiness for the baseline set of
    laboratories and facilities.

-   The Contract Management and Administration section describes the
    contract-wide activities that support both Part 1 and Part 2 of the
    contract.

## Baseline Operational Readiness

The contractor shall maintain a baseline set of facilities and
laboratories, both government furnished and contractor furnished, at
operational readiness for Bioastronautics activities at JSC. The concept
of baseline operational readiness is that the contractor shall provide
**operational** facilities and laboratories that are ready **when
needed** and have the **capacity** to get the work done.

The overall requirement is a set of highly functional facilities and
laboratories that are carefully managed to provide maximum efficiency
and effectiveness, that are ready to operate with short notice, and that
are capable of accomplishing the work in Part 2 of the contract.

### Operational facilities and laboratories

The contractor shall identify a baseline set of laboratories and
facilities, including both government furnished and contractor
furnished, that can fully accomplish the work in Part 2 of the contract.
Each facility or laboratory has both general and specific requirements
that define operational readiness for that facility or laboratory. The
general requirements for every baseline facility and laboratory are
listed here.

For every baseline facility and laboratory (herein referred to
collectively as facilities) the contractor shall provide:

-   Safety and health standards and practices,

-   Written procedures or work instructions for activities in the
    facility,

-   Fully trained and skilled staff to operate the facility at its full
    technical potential,

-   Schedules for the work in the facility,

-   SRM&QA procedures and/or input to JSC procedures appropriate to the
    products and activities in the facility,

-   All supplies and expendables needed to operate,

-   Humidity and temperature control for maximum performance of the
    facility,

-   Assurance of security for the facility,

-   Property management for all property in the facility,

-   Control of samples and other customer provided materials,

-   Data systems that accurately record and preserve data,

-   Security and confidentiality for sensitive data,

-   Emergency plans and procedures,

-   Identification of all hazards and plans to mitigate those hazards,

-   Environmental safeguards for conservation and proper waste disposal,

-   Biological safeguards and practices,

-   Calibrations for all items in the facility requiring calibration,

-   Clean and orderly facilities,

-   Routine inspections for safety and health issues,

-   Hazardous chemical inventories,

-   Assurance of continuous function of refrigerators and freezers and
    other continuously operating equipment,

-   A system of work accountability that correctly tracks and reports
    time and materials against the appropriate accounts,

-   Assurance that computers and other IT equipment are available to the
    facility,

-   Maintenance, repair, and replacement of equipment in the facility,

-   Innovations to improve the effectiveness and efficiency of the
    facility,

-   Metrics that reflect the operational readiness, effectiveness, and
    efficiency of the facility

The contractor shall create and maintain a Baseline Operational
Readiness Plan. The plan shall identify each laboratory or facility,
either government furnished or contractor furnished, that is included in
the baseline set. All requirements, certifications, calibrations and
other factors that define baseline operational readiness shall be listed
for each laboratory or facility. The government will approve the
Baseline Operational Readiness Plan. The approved Plan defines the
performance standard for the Baseline Operational Readiness task.

The contractor shall maintain configuration control of the baseline
facilities and laboratories consistent with the approved Baseline
Operational Readiness Plan.

### Scheduling and Capacity

Scheduling is a critical function required to optimize the efficiency
and effectiveness of the baseline facilities and laboratories. The
contractor shall maintain schedules for the baseline facilities and
laboratories. The contractor shall maintain and report metrics on the
level of utilization of each baseline facility and laboratory including
the demands for its services that were met and the demands that were not
met.

The contractor shall augment the capacity of any facility or laboratory
that cannot meet the peak demands for its services or find innovative
means to meet peak loads.

### Assigning Costs

The baseline operational readiness task has met its objective when the
facility or laboratory is operationally ready when needed to accomplish
scheduled work for a task or delivery order written on Part 2 of the
contract. It is the responsibility of the baseline operational readiness
task to have the facility ready; it is the responsibility of the IDIQ or
LOE task or delivery order to carry out the tasks that are scheduled for
the facility.

The contractor shall clearly account for work done in every baseline
laboratory and facility with respect to the distinction between Part 1
baseline operational readiness and other core functions and Part 2 task
and delivery orders. Reference the Contractor Financial Management
Reports DRD.

### Annual Assessment of the Baseline Operational Readiness

The contractor shall annually assess the baseline operational readiness
function of the Bioastronautics Contract and propose actions to provide
baseline operational readiness with the best effectiveness and
efficiency. The assessment and proposed actions shall be reviewed and
approved by the government prior to implementation. Reference the Annual
Assessment of Baseline DRD.

## Contract Management and Administration 

### Contract Management 

The contractor shall be responsible for the management of the contract
to assure accomplishment of contract work and compliance with contract
provisions. The contractor shall prepare and maintain a comprehensive
Management Plan that identifies key personnel, associates all
subcontracts with the work they support, and includes an accurate
organization diagram. Reference the Management Plan and Organization
Chart DRDs.

The contractor shall be responsible for the timely procurement and
receipt of supplies, materials, hardware, and services necessary to
fulfill contract requirements. The contractor shall provide logistics
support necessary to support both Part 1 and Part 2 of the contract.

### Safety and Health

The contractor shall perform tasks to ensure the protection of
personnel, property, equipment, and the environment in contractor
products and activities.

To ensure compliance with NASA policies and requirements and federal,
state, and local regulations for safety, health, environmental
protection, and fire protection, the contractor shall develop, plan, and
implement an independent system safety program to assure that hazards
and their consequences are identified, evaluated, and controlled
throughout all phases of the program. The government will review and
approve the contractor's system safety program.

The contractor shall implement system safety engineering tasks for
flight and institutional program activities and products in accordance
with the schedule and applicable flight and institutional requirements
as documented in the contractor's system safety program plan.

The contractor shall develop and implement risk management techniques to
be applied to hazards derived from analyses of activities and products
for the purpose of eliminating or controlling hazards as specified in
NASA policies and requirements for hazard reduction The JSC Safety and
Health Handbook provides detailed requirements and instructions
regarding safety and health procedures and policies at JSC.

The contractor shall provide a NASA approved Safety and Health Plan, and
the contractor shall provide other safety related deliverables as
specified in the DRDs.

Performance standard for the Safety and Health section of the SOW is NPG
8715.3, "NASA Safety Manual."

### Quality Management System (QMS)

The contractor shall provide a Quality Management System (QMS) that
complies with ANSI/ISO/ASQ Q9001-2000 as a core function to be
implemented across the entire contract at JSC and at contractor offsite
facilities. The contractor shall comply with the contractor's QMS for
work performed at the offsite facilities. The contractor's Quality
Management System shall comply with ANSI/ISO/ASQ Q9001-2000. The
contractor's QMS shall be registered by an accredited third party within
one year of contract start date.

Onsite at JSC, when processing space flight hardware, software, or
ground support equipment, the contractor shall comply with NT-CWI-001
(Task Performance Sheet) for work performed, and NT-CWI-003 (QARC
\[Quality Assurance Record Center\] Discrepancy Reporting and Tracking)
for control of nonconforming product. In addition, when preparing to
ship equipment for flight, the contractor shall follow NT-CWI-004
(Flight Equipment Pre-Shipment Readiness Review), or develop an
equivalent procedure for NASA approval. The contractor shall comply with
the JSC QMS for work performed at JSC onsite facilities.

The contractor shall regularly assess the risks threatening the
successful completion of work on the contract and undertake activities
to mitigate those risks. The assessments and the efficacy of the
mitigating activities shall be reported during regular performance
reviews.

The contractor shall understand, anticipate and take positive steps to
meet both internal and external customer needs. The contractor shall
systematically measure and analyze customer satisfaction with the
products and services of the contract and with the products and services
of the Office of Bioastronautics as a whole and shall report customer
satisfaction metrics to the government on a regular basis.

Specific task order / delivery orders include additional data
requirements descriptions (DRDs) that are applicable to flight hardware
and other deliverables. Reference the Quality Plan DRD.

[Performance standard]{.underline} for the Quality Management System at
the contractor's facilities and JSC is ANSI/ISO/ASQ Q9001-2000.

### Environmental Management System (EMS)

The contractor shall provide an Environmental Compliance Plan that will
ensure compliance with environmental contract requirements.

The contractor shall ensure that all activities performed and equipment
used to fulfill the requirements of this contract are in compliance with
all local, state, and federal regulations; environmental Executive
Orders (EO) including, EO13101, 13123, and 13148; and NASA JSC
directives, procedures and policies.

The Government remains the owner and operator of record for all
environmental activities conducted at NASA owned properties unless
otherwise documented in a signed agreement between NASA and the
contractor. For on-site issues, JSC\'s Environmental Office will be the
single point of contact with regulators unless otherwise directed by the
Contracting Officer or the Environmental Office. This includes
correspondence, permit applications, on-site inspections, and other
similar items to regulatory agencies.

The contractor shall conduct all onsite work in compliance with JSC\'s
Environmental Management System (EMS). This includes identifying all
contractor aspects (activities, services and products) that have
environmental impacts. In general, these activities are broadly defined
and not task-level. These aspects shall be evaluated prior to initiating
new work and reviewed annually and updated as needed. The contractor
shall control all aspects with impacts through procedures or engineering
controls or other appropriate methods. The contractor shall document
these controls. The contractor shall take corrective action in
accordance with the EMS when environmental nonconformance or
noncompliance is identified. The contractor shall maintain and repair
all equipment adequately to prevent an environmental nonconformance or
noncompliance.

All on-site contractor personnel shall attend environmental training
specified and provided by the JSC Environmental Office for the type of
work conducted. In general, this training shall be between 1 (office
workers) and 6 (employees performing or supervising multiple potential
pollutant generating activities) hours per year.

In order to support the Government\'s goals for greening the government
(such as, reducing the quantity and toxicity of pollutants used and
released to the environment, reducing the amount of solid waste placed
in landfills, and conserve resources through reduction of energy and
water usage) the Contractor shall incorporate the following into all
activities performed.

-   The contractor shall use environmentally friendly alternatives when
    selecting materials, equipment and processes wherever they will meet
    performance requirements and are of comparable cost to other
    alternatives. Environmentally friendly is defined as utilizing or
    enhancing conservation of resources (energy, water, renewable and
    non-renewable resources) and/or generating reduced quantity of or
    less toxic pollutants (ozone depleting substances, hazardous wastes,
    air pollutants).

-   All on-site contractor personnel, including subcontractors, shall
    place appropriate unused or discarded materials into JSC\'s
    recycling programs, including: scrap metal, batteries (lead,
    nickel/cadmium, silver, mercury), fluorescent lamps, paper,
    cardboard, pallets, aluminum cans, and any other material where
    on-site recycling is available.

-   The use of life cycle costing is encouraged for use in
    decision-making when selecting materials, equipment and processes
    (including environmental costs for energy and water usage, waste
    disposal, regulatory oversight and permitting, and ultimate
    disposal).

-   The contractor shall proactively implement procedures and processes
    to reduce the amount of solid waste (trash) generated by its
    activities.

-   The contractor shall comply with affirmative procurement
    requirements for all products procured by the contractor for the
    performance of all contract requirements (including subcontractors)
    as identified in FAR, NASA NPG and JSC procedures. Starting in FY04,
    the contractor shall submit waivers for approval by the
    Environmental Office for each product purchased by the contractor
    that does not meet affirmative procurement requirements prior to the
    procurement of a non-conforming product. The contractor shall track
    and report each February 1 to the JSC Environmental Office the
    following information regarding the purchase of all products on the
    Environmental Protection Agency\'s Comprehensive Procurement
    Guideline list:

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-   The total amount of each listed item purchased during the fiscal
    year in dollars,

-   The total amount of each listed item purchased during the fiscal
    year that contained recommended percentages of recycled content
    during the fiscal year in dollars, and

-   A narrative explanation of constraints for purchasing each item that
    did not meet affirmative procurement requirements during the fiscal
    year.

### Safety, Reliability, Maintainability, and Quality Assurance (SRM&QA)

**Quality Assurance Responsibility**

Space Flight Hardware/Software Procurements

The contractor shall submit procurement documents for space flight
hardware, software, or ground support equipment to the designated NASA
quality representative for determination of the need for Government
Source Inspection (GSI) prior to release of the procurement.

\(a\) Procurements that require GSI shall include the following
statements:

> "All work on this order is subject to inspection and test by the
> Government at any time and place. The Government quality
> representative who has been delegated quality assurance functions on
> this procurement shall be notified immediately upon receipt of this
> order. The Government representative shall also be notified 48 hours
> in advance of the time articles or materials are ready for inspection
> or test."

\(b\) Procurements that do not require GSI shall include the following
statement:

> "The Government has the right to inspect any or all of the work
> included in this order at the supplier's plant."

Product Identification

Contractor flight hardware, flight software, and ground support
equipment products fabricated, tested, or processed onsite at JSC shall
be identified in a manner distinctly different from JSC identification
methods (e.g. JSC 911 Tags), prior to government acceptance.

Review and Disposition of Nonconforming Product

At off-site facilities, the Government representative will approve all
dispositions of nonconforming product except rework to specification.
On-site review and disposition of nonconforming product is covered in
NT-CWI-003, QARC (Quality Assurance Record Center) Discrepancy Reporting
and Tracking.

Traceability

The contractor shall maintain the ability to trace and ensure
identification of all materials/products, whether separately produced
discrete items or material produced in lot/batches, to the original
source/manufacturer and to determine verification status. This system
shall be maintained throughout the life of this contract, including
material/product receipt, all stages of production, delivery,
installation, etc.

Pressure Vessels and Pressurized Systems

The contractor shall assure the requirements of JHB 1710.13, "Design,
Inspection, and Certification of Pressure Vessels and Pressurized
Systems," are met for all ground based Pressure Vessels/Systems (PV/S)
that are owned and/or operated by JSC, and all PV/S that are used on JSC
property. The SRM&QA Pressure Systems Manager's Office will provide
specific services to the contractor in accordance with the provisions of
JHB 1710.13.

Fastener Integrity

The contractor shall comply with JSC 23642, JSC Fastener Integrity
Program. The contractor may negotiate utilization of the JSC Receiving
Inspection and Test Facility (RITF) services for verification testing
and inspection of externally threaded fasteners procured for use on JSC
programs.

Calibration

Inspection, Measuring, and Test Equipment (IM&TE) that affects quality,
shall be controlled in accordance with ISO 10012-1, Quality Assurance
Requirements for Measuring Equipment. If the JSC Measurement Standards
and Calibration Laboratory (MSCL) is used for calibration services, the
contractor shall adhere to JSC's System Level Procedure 4.11, Control of
Inspection, Measuring, and Test Equipment.

Contractor-developed performance metrics used for NASA surveillance

The contractor shall collect and compile information derived from
contractor data (i.e., test results, analysis reports, inspection
records, discrepancy data, nonconformance data, delivery logs, etc.) to
demonstrate that the products and services delivered to the government
are in compliance with the requirements and specifications as specified
in this contract. The delivery of the compliance information shall be at
the request of the government, either specifically through this contract
or on request of the appropriate government interface.

Quality Plan

The contractor shall develop a Quality Plan specifically for this
contract as specified in the Quality Plan DRD. Reference the Quality
Plan DRD.

Software Quality Assurance (SQA) Plan

The contractor shall prepare an SQA Plan and Software Acceptance Data
Package (ADP). The contractor shall implement the SQA requirements in
accordance with the approved SQA Plan as specified in the DRD.

The contractor shall comply with software quality assurance requirements
as applicable to the following categories of software and firmware:
flight software and firmware; critical ground support software and
firmware, i.e., software and firmware that are an integral part of the
operational mission (i.e., support of flight program); and software
support tools used in (1) the development of flight and critical ground
support software and firmware; (2) manufacturing processes of mission
critical hardware; and (3) test and integration of mission critical
hardware, software, and firmware.

EEE Parts Control Plan

The contractor shall provide an EEE Parts Control Plan in compliance
with SSP 30312, EEE Parts and Management and Implementation Plan and as
specified in the DRD.

Reliability & Maintainability Plan

The contractor shall develop and implement a reliability and
maintainability program to assure implementation and verification of
reliability & maintainability requirements, and to evaluate
characteristics. As part of this program the contractor shall develop a
Reliability & Maintainability Plan in accordance with the Reliability &
Maintainability (R&M) Plan DRD.

Problem Reporting and Corrective Action (PRACA)

The contractor shall comply with JSC 28035, Program Requirements for JSC
Government Furnished Equipment (GFE) Problem Reporting and Corrective
Action (PRACA) as specified in the DRD.

Government and Industry Data Exchange Program (GIDEP) and NASA Advisory
Problem Data Sharing and Utilization Program Documentation and Reporting

Using the GIDEP and NASA Advisory Problem Data Sharing and Utilization
Program Documentation and Reporting DRD as a guide, the contractor shall
provide a documented response on each requested ALERT (Acute Launch
Emergency Reliability Tip) or NASA Advisory, investigation and
resolution to NASA/JSC. Program/project initiated ALERTs are
disseminated by the NASA/JSC contractors.

### Earned Value Management System (EVMS)

The contractor shall establish an Earned Value Management System that
reports the contractor's performance to Statement of Work tasks
performed.

The contractor's Earned Value Management System shall comply with
Section H clause NFS 1852.242-76 "Modified Cost Performance Report".
Cost Performance Reports submitted shall be submitted in accordance with
the DRD entitled "Cost Performance Report".

The Contractor shall present monthly Program Management Reviews that
address the progress of the work reported on in the Cost Performance
Reports. The Program Manager shall present the review to the Contracting
Officer, COTR, NASA Technical Leads, and Budget Analyst. Specific format
and detail of the data to be presented along with the specific dates
when the reviews will occur shall be approved by the COTR. Reference the
Cost Performance Reports DRD.

### Cost estimating for IDIQ and LOE Tasks

One of the goals of this contract is to conduct the business of the
contract in the most efficient and cost effective manner consistent with
a high level of management insight and control. Accurate estimates
permit the full utilization of resources to accomplish the
Bioastronautics work in a very constrained budgetary environment.

The Contractor shall implement a system of rapid and accurate cost
estimating for IDIQ and LOE task orders and delivery orders.

### Financial Reporting

Accurate reporting of costs is a contract requirement and a necessity
for properly managing both the work and the available resources. The
goal of this task is reliable and timely data that accurately reflect
the cost incurred on the contract at the level of detail needed to
manage the tasks and subtasks on the contract.

The contractor shall provide accurate, complete, and timely financial
reports.

The contractor shall provide supplemental reports to the government that
accurately reflect the financial status of work at the task and subtask
level.

Reference the Contractor Financial Management Reports DRD.

### Facilities and Equipment Management

The activities of the Office of Bioastronautics are conducted in
government-furnished laboratories and facilities and in
contractor-provided laboratories and facilities. The goal of this task
is a set of Bioastronautics facilities and laboratories that are
state-of-the-art, fully functional, and capable of accomplishing the
work in Part 2.

The government makes laboratories and facilities available for the
contractor's use for Bioastronautics activities. The government will
maintain a listing of the facilities, laboratories, and equipment that
are available for Bioastronautics activities (Section J). The contractor
shall provide laboratories and facilities supplemental to those
furnished by the government such that the combined set of facilities and
laboratories can accomplish the work in Part 2.

The contractor has the use of government furnished property. The
contractor shall maintain the functionality of the government property
that it uses including all required calibrations and certifications. The
contractor shall keep equipment in good repair or replace it as
required.

Performance standard: Clause 52.245-97 (Section G).

### 1.2.10 Management and Security of Information Technology (IT) {#management-and-security-of-information-technology-it .unnumbered}

Effective use of information technology that is provided through the JSC
institutional IT provider requires administrative activities to develop
and implement IT plans for the all Bioastronautics activities. Some
Bioastronautics activities have IT requirements that are not met by the
JSC institutional IT provider. Meeting these requirements also requires
an IT plan.

The Contractor shall assess the IT needs for all Bioastronautics
activities annually, create IT plans that capture those needs, and keep
those plans current with changing requirements throughout the year. The
plans shall cover both contractor and government IT requirements. The
contractor shall track and report actual IT purchases against the plans.

The security of computer hardware and software is paramount to the
success of the Bioastronautics mission. The contractor shall maintain
the security of the IT systems in the Office of Bioastronautics such
that they pass vulnerability scans prescribed by the JSC Chief
Information Officer. The contractor shall create and implement IT risk
analyses and security plans that fully comply with JPG 2810.1B (or
subsequent version). The contractor shall assume the responsibility for
maintaining security on IT systems at the effective date of the
contract. The contractor shall assume responsibility for the risk
analyses and the new or revised security plans for IT systems as they
are renewed or changed such that the contractor shall have assumed full
responsibility by January 1, 2004. This is an intentional overlap with
the risk analysis and security planning provided by NAS9-19100.

The contractor shall provide sustaining IT security engineering that
includes vulnerability analysis and resolution and coordination with
Bioastronautics user organizations. The contractor shall evaluate and
deploy new IT that takes advantage of emerging technologies and that is
compatible with agency and center architectures and standards.

The contractor shall plan an integrated, interoperable IT infrastructure
compatible with agency and center standards and processes to enable
secure information exchange and resource sharing. This shall include
network planning and administration, system administration, IT security
plan development, including computer security risk analysis, and
disaster recovery planning.

The contractor shall plan, budget, acquire, and evaluate performance of
investments in IT in a manner that is integrated and aligned with
Bioastronautics, agency and center planning, budgeting, program
management, and implementation processes.

The contractor shall create and evaluate mission-based performance
measures for IT investments to ensure that IT is efficiently and
effectively meeting Bioastronautics mission and program needs,
supporting optimal business practices, and demonstrating the projected
return on investment.

Reference the Information Technology Capital and the Automated
Information Systems DRDs.

*In addition to any other requirements of this contract, all individuals
(contractor or subcontractor) who perform tasks as a system
administrator or have authority to perform tasks normally performed by
system administrator shall be required to demonstrate knowledge
appropriate to those tasks. This demonstration, referred to as the NASA
System Administrator Security Certification, is a NASA funded two-tier
assessment to verify that system administrators are able to --*

* *

> *1.      Demonstrate knowledge in system administration for the
> operating systems for which they have responsibility.*
>
> *2.      Demonstrate knowledge in the understanding and application of
> Network and Internet Security.*

* *

*Certification is granted upon achieving a score above the certification
level on both an Operating System test and the Network and Internet
Security Test. The Certification earned under this process will be valid
for three years. The criteria for this skills assessment has been
established by the NASA Chief Information Officer. The objectives and
procedures for this certification can be obtained by contacting the IT
Security Awareness and Training Center at (216) 433-2063.*

* *

*A system administrator is one who provides IT services, network
services, files storage, web services, etc. to someone else other than
themselves and takes or assumes the responsibility for the security and
administrative controls of that service or machine. A lead system
administrator has responsibility for information technology security
(ITS) for multiple computers or network devises represented within a
system; ensuring all devices assigned to them are kept in a secure
configuration (patched/mitigated); and ensuring that all other system
administrators under their lead understand and perform ITS duties. An
individual that has full access or arbitrative rights on a system or
machine that is only servicing themselves does not constitute a \"system
administrator\" since they are only providing or accepting
responsibility for their system. An individual that is only servicing
themselves is not required to obtain a System Administrator
Certification.*

### 1.2.11 Direct Administrative Support {#direct-administrative-support .unnumbered}

The program level functions of the Office of Bioastronautics include the
administration of grants to research organizations extramural to JSC and
administrative support for boards, panels, and committees.

The Contractor shall provide administrative support for up to 200 grants
per year that are administered by Office of Bioastronautics. The
elements of this task include preparing the appropriate documents
required by the grant procurement office, maintaining technical files
for grants, their status, their periodic progress reports, and
maintaining financial records associated with the grants.

A system of boards, panels, and committees review, approve, and control
the Bioastronautics activities. The overall objective of this task is to
provide a fully integrated system that supports the operation of all the
boards, panels, and committees in Bioastronautics. This support extends
to science meetings, Bioastronautics Product Teams, Integrated Product
Teams, Science Working Groups, and Technology Development workshops and
meetings.

The Contractor shall schedule and arrange logistics for up to 500
meetings per year, systematically record the proceedings of these
meetings including all actions. The contractor shall integrate and
correlate these records across all Bioastronautics activities and
maintain an up-to-date, cross-referenced, and accessible record and
status for all actions from all boards, panels, and committees. All
proceedings of meetings shall be captured within 3 working days of the
date of the meeting.

###  {#section .unnumbered}

### 1.2.12 Communicating, reporting, and metrics {#communicating-reporting-and-metrics .unnumbered}

The outcome of this task is clear, concise communication of information
produced by the Bioastronautics Contract, both management information
that reports progress and problems and technical information that is
essential for the Office of Bioastronautics to accomplish its mission.

The contractor shall maintain reporting systems that make full use the
capabilities of the JSC institutional computing and communications
systems. The contractor shall improve the reporting system as the
institutional computing and communication systems improve.

The contractor shall create and evolve a set of meaningful technical and
management metrics for the Bioastronautics Contract and for the entire
Office of Bioastronautics. The government will review and approve
Bioastronautics metrics.

# Part 2: Bioastronautics Operations, Research, and Flight Hardware

Part 2 includes scope for Bioastronautics research, operations support,
and flight hardware development and integration. The following technical
discipline descriptions provide a broad perspective on the roles and
responsibilities within each discipline. They provide the framework for
the development of tasks to be conducted by the contractor.

## Habitability and Environmental Factors

The Bioastronautics mission of this discipline area is to assure that
all human-occupied environments during space missions promote crew
health, safety, and performance. The contractor shall perform
operational assessments, technology development projects, and
peer-reviewed research, and the contractor shall support hardware
development and operations to enhance crew health, safety and
performance using state-of-the-art laboratories and facilities.
Habitability and Environmental tasks include:

-   Human Factors and Habitability -- research, analysis, design, and
    verification of crew system design and operations.

-   Space Food Development & Provisioning -- research,
    menu/packaging/hardware design, and provision of food to flight
    crews.

-   Advanced Technologies -- early, rapid virtual prototyping of
    hardware and spacecraft design concepts; identification of emerging
    technologies to apply habitability or environmental factors

-   Environmental Factors -- oversight of mission environments and
    research, testing, and analysis of crew environments to protect
    their health and safety.

-   Development of Certificate of Flight Readiness -- validating that
    the spacecraft design and environment is prepared to support the
    health and productivity of the crew.

Bioastronautics has programmatic responsibility for the implementation
the Advanced Human Support Technology (AHST) Program and the AHST Space
Human Factors Project. This involves oversight of on-going research
activities, technical support for the development and implementation of
annual NASA Research Announcements (NRAs), and grant and contract
implementation for the research selected to be a part of the program.

Habitability and Environmental Factors has interactions with various
Programs and Offices and International Partners. These include the
NSBRI, the International Space Station and its sub-offices, Shuttle
Program Office; NASA Headquarters Code U, the Biomedical Research and
Countermeasures (BR&C) and Space Medicine Programs.

### General

The contactor shall develop and validate requirements and standards,
identify and mitigate environmental risks, conduct research and
analysis, and provide sound space human factors engineering and
operational support to NASA's flight programs. Successful implementation
of this contract will result in the following critical outcomes:

-   Risks to crew health, safety and performance due to spacecraft
    internal and external environments and crew-hardware interfaces are
    identified and characterized.

-   Abatement plans are successfully implemented to control these risks
    to well defined, acceptable levels.

-   Human factors and environmental expertise have been integrated with
    all elements of hardware design, operations planning, and
    implementation.

The contractor shall characterize and analyze flight hardware within the
operational environment of the vehicle. The contractor shall track and
manage the internal configuration of the vehicle. On the basis of
information and analyses of habitability and human factors engineering,
the contractor shall make recommendations on certification of flight
readiness for specific missions.

The contractor shall provide laboratory, technical, scientific, and
logistics support for flight and ground-based research on safe and
productive human habitation of space. This includes research in human
health, engineering, and exploration conducted on the ISS, the Shuttle,
and in JSC ground-based facilities. The research also includes
ground-based and flight studies of human adaptation to reduced gravity
environments. The contractor shall provide similar support to research
and development of countermeasures for the effects of radiation on
biological, chemical and physical systems in space and on other
planetary surfaces. The results of the research will enable human
exploration beyond Earth orbit, support commercial research, and improve
the health, safety and quality of life for people on Earth.

The contractor shall provide technical and logistics support for
outreach and education activities including special projects, demos,
displays, seminars and presentations. The contractor shall develop
program materials including various program publications (e.g.,
brochures, multi-media products, exhibit materials).

Most outreach and education projects are dynamic in nature. The
contractor shall provide various exhibits for a specific task/audience
(e.g., exhibit/brochure development and display for a particular
conference). The contractor shall provide presentations or displays
suitable for specific audiences: college, graduate, and postgraduate,
high school teachers and students; young students (7^th^-10^th^ grades);
local and national meeting audiences; congressional members and staff;
dignitaries; various high-ranking public officials. The contractor shall
serve as an educational consultant to classroom activities and
visitations by students and serve as mentor to university classes on
topics relevant to current HEFO responsibility.

### Habitability and Human Factors 

#### Hardware Requirements Development and Verification

The contractor shall develop requirements for crew habitability hardware
systems. These requirements are followed from concept through hardware
build. The contractor shall provide human engineering expertise to the
design and development of the hardware. The contractor shall model,
analyze and evaluate crew tasks and human-machine interfaces. Concepts
shall be evaluated within the Space Human Factors Laboratories. Hardware
and payloads shall be examined for compliance to human engineering and
proper labeling requirements.

#### Space Food Systems

The contractor shall support meeting the nutritional requirements of the
crew. The contractor shall support the design and development of food
items and menus for Shuttle and ISS flights. The contractor shall
support food packaging and provisioning for both programs. The
contractor shall support advanced food systems research and development
to maximize the palatability and nutrition while minimizing the use of
resources (power, mass, volume). Examples of this research include shelf
life studies, and development of extended shelf-life food products, and
development of crop-based food systems.

### Environmental Factors 

#### Acoustics

The contractor shall provide:

-   Oversight of ISS modules, payloads and GFE for acoustics;

-   Support of on-orbit acoustic measurements and follow up analyses and
    reports;

-   Characterization of the spacecraft acoustical environments; and

-   Mitigation of acoustical risks.

The contractor shall investigate and recommend acoustic materials for
use in specific locations and spacecraft operating environments. The
contractor shall provide testing, analyses, and review of spacecraft,
payloads, and GFE designs.

#### Microbiology

The contractor shall provide operational support to flight programs, to
the JSC Flight Medicine Clinic, and to the Occupational Health Clinic.
Microbiology supports clinical and environmental requirements and a
robust research component. The contractor shall be responsible for
collecting, culturing, and analyzing specimens from the crew and from
the spacecraft environment. The contractor shall define and execute
pre-flight, on-orbit, and post-flight microbiology operations and
activities. The contractor shall review and update programmatic
microbiology requirements and identify, track and resolve issues. The
contractor shall develop and implement environmental monitoring
strategies and schedules and shall support any related hardware
development. The contractor shall culture and analyze specimens from the
JSC Flight Medicine Clinic and specimens from the Occupational Medicine
Clinic and Test Subject Facility.

The contractor shall conduct peer-reviewed operationally relevant
research and provide technical support to the JSC Biosafety Review
Board.

#### Radiation 

Safe human spaceflight requires that crews live and work within
acceptable risks from space radiation exposures. The contractor shall
perform radiation risk assessments, observe and forecast space weather,
provide real-time mission support and training, prepare and analyze
physical dosimeters, and employ biodosimetry methodology. The contractor
shall perform the analyses required to advise astronauts of their risk
from all occupational radiation exposures. Federal regulations on
radiation exposure apply to this activity. A secret security clearance
is required for certain mission support tasks.

The contractor shall support radiation research to enable the safe human
exploration and development of space within acceptable risks from space
radiation exposures. The contractor shall assist in conducting space
radiation research and advocating Bioastronautics Critical Path Roadmap
goals. Collaboration with other US institutions (academia, NSBRI,
National Labs), Federal Agencies (Department of Energy, National Cancer
Institute, Department of Defense), and international partners is
essential to radiation health safety.

#### Toxicology

The contractor shall perform hazard assessments of payload and
spacecraft system chemicals and off-gas testing of hardware. The
contractor shall conduct analyses of samples to assess crew health risks
and support the preparation and delivery of on-orbit instrumentation for
monitoring of environmental quality. The contractor shall investigate
advanced air monitoring technologies and recommend instrumentation
upgrades. The contractor shall provide mission support and analyses and
report trends in data from air quality monitors. The contractor shall
propose and document standards for health assessment of air quality. The
contractor also shall support the operation of the JSC Animal Care
Program and crew involvement with animals associated with spaceflight
experiments.

#### Water Quality

The contractor shall provide comprehensive chemical analyses of food and
water samples in support of NASA flight program operations. The
contractor shall provide expertise to assess life-support systems for
continued crew health, including technical and environmental engineering
oversight of water system servicing, and coordination of water sampling
and analyses. The contractor shall investigate advanced water monitoring
technologies and recommend instrumentation upgrades. The contractor
shall provide complete post-mission reporting of all potable water
quality efforts, including a summary of water servicing activities and
water quality analytical results. The contractor shall propose and
document standards for assessment of water quality.

#### Advanced Technologies 

The contractor shall provide the capability for rapid prototyping and
evaluations in a 3-dimensional virtual world, thereby testing the
feasibility of design and operations concepts early in the study or
development process. The contractor shall identify and shall assess
emerging technologies that enable and enhance crew operations, human
interface and control, and environmental monitoring. The results of
these tests support requirement development and design definition. This
capability is available to all NASA programs.

A major emphasis in this area is leadership and innovation in advanced
programs (e.g. Space Launch Initiative \[SLI\]). The contractor shall
provide technical, engineering, programmatic, and management expertise
and shall facilitate collaborative work with other federal agencies
(e.g., Department of Defense, Department of Transportation, Federal
Aviation Administration, National Security Agency, and the Office of
Homeland Defense).

## Human Adaptation and Countermeasures 

The Bioastronautics mission of this discipline is to perform biomedical
research focused on understanding the normal human response to space
flight. The contractor shall perform medical tests on crewmembers in
support of Space Medicine and Health Care Systems. The contractor shall
also provide operational biomedical laboratory support to Space Medicine
and Health Care Systems in support of ensuring crew safety, health, and
performance. These operational responsibilities include laboratory and
discipline-specific support before, during, and after a space flight
mission. The contractor shall evaluate, validate, and certify the
optimal complement of countermeasures required to maintain the
functional abilities of astronauts during and after both short- and
long-duration space flight. This knowledge is critical to NASA's human
space flight program and to its capability to carry out human
exploration-class missions. The Human Adaptation and Countermeasure
mission reflects the priorities in the Bioastronautics Critical Path
Roadmap (BCPR) and in the Astronaut Medical Evaluation Requirements
Document.

Elements critical to the success of Human Adaptation and Countermeasures
include:

-   Scientific research over a wide range of physiology disciplines
    supporting the development of new countermeasures.

-   Implementation of projects to evaluate and validate potential
    countermeasures.

-   Operational support for human space flight with mission scientists
    and laboratory support for operations on all human space missions.

-   Integration of all aspects of the Biomedical Research &
    Countermeasures (BR&C) Program and management oversight of flight
    experiments and science integration.

-   Support to education and outreach efforts to audiences ranging from
    the general public to graduate level education.

### Human Space Flight Missions

Bioastronautics has programmatic responsibility for the implementation
of the Biomedical Research and Countermeasures (BR&C) Program. This
involves programmatic oversight of on-going research activities,
technical support for the development and implementation of annual NASA
Research Announcements (NRAs), and grant and contract implementation for
the research selected to be a part of the program. The contactor shall
provide laboratory and discipline specific testing of the fight crew in
support of Space Medicine Objectives (SMO) operations. This includes
identifying supporting tasks, establishing the schedule for
deliverables, performing the tasks and providing accurate and timely
responses. The requirements for these tasks are outlined in the Medical
Requirements Integration Documents (MRIDs).

### Research on Human Adaptation and Countermeasures

The contractor shall provide technical, science, engineering and
logistics support to Human Adaptation and Countermeasures for the whole
range of basic, applied, and operational research both on the ground and
in flight. The contractor shall provide critical technical and
scientific expertise required for supporting a wide range of discipline
specific research efforts. This expertise includes understanding and
following research processes and protocols and interfacing with both
engineering and flight operational teams to ensure the success of the
research. All research personnel shall be trained and adhere to all
Committee on the Protection of Human Subjects (CPHS) ethical guidelines.

### Countermeasures Evaluation & Validation Project (CEVP)

Bioastronautics has the responsibility to plan and implement the
Countermeasure Evaluation and Validation Project. This project
encompasses a wide range of ground, ground analog and flight experiments
in support of assessing and certifying new countermeasures to be
utilized by Space Medicine and Health Care Systems to ensure crew
safety, health and performance. The contractor shall support the
programmatic, technical, medical, and operational activities of the
CEVP. The contractor shall support the implementation and management of
flight and ground experiments and protocol to validate the effectiveness
of new countermeasures. CEVP also requires close collaboration and
teamwork with extramural and intramural investigator teams. The
contractor shall establish procedures, protocols, and schedules for the
validation projects, implementation of the projects, and evaluation of
countermeasures based on the experimental data.

### Exercise Countermeasures Project (ECP)

The contractor shall support the programmatic, technical, medical, and
operational activities of the Exercise Countermeasures Project (ECP).
Bioastronautics Human Adaptation and Countermeasures is responsible for
the administration of the ECP. To support the goal of ECP, the
contractor shall develop and implement effective and efficient exercise
countermeasures to maintain, enhance, and assure the performance and
health of Astronauts during all phase of mission training and
operations. The contractor shall:

-   Evaluate and validate exercise hardware, modalities, and routines to
    determine their efficacy and efficiency as countermeasures to loss
    of bone and muscle strength, and cardio-respiratory functional
    capacity associated with long-duration exposure to microgravity,

-   Determine the effect of pre-flight Astronaut physical conditioning
    on all phases of in-flight physiological adaptation responsiveness
    and health maintenance during short-term and long-duration exposure
    to microgravity

-   Determine the effect of in-flight physical conditioning and specific
    exercise modalities and routines on post-flight test responses and
    rehabilitation after short-term and long-duration exposure to
    microgravity

-   Determine the effectiveness of the ISS Exercise Plan in the
    maintenance and promotion of crewmember health during ISS missions

-   Develop descriptive profiles and summary statistics of ISS crew
    compliance to the Increment Exercise Plan, and establish
    correlations among pre-flight, in-flight, and post-flight factors
    and variable measures.

### Pre-breathe Reduction Protocol Project

The contractor shall support the programmatic, technical, medical, and
operational activities of the Prebreathe Reduction Project. It is a
multi-year effort to minimize the need for prolonged and logistically
demanding EVA pre-breathe procedures. The contractor shall support the
overall objective for the Phase V study to validate a low intensity,
intermittent exercise protocol as a technique to reduce pre-breathe time
for astronauts. The integrated phase V laboratory/operational
development program is focused on the following components

-   Laboratory physiological testing

-   Flight hardware development and certification

-   Flight Detailed Technical Objective (DTO) or Detailed Supplementary
    Objective (DSO) to verify and quantify exercise intensities and
    exercise dose control using 0~2~ tank pressure drop

-   Crew training and ground support equipment

### Artificial Gravity Project (AG)

The contractor shall support the programmatic, technical, medical, and
operational activities of the Artificial Gravity (AG) Project. The AG is
dedicated to determining if either partial or 1-g artificially induced
gravity field during long duration space flight can serve as a
multi-system countermeasure to mitigate the adverse effects known to
occur during long duration space flight. The contractor shall perform
the necessary ground and flight experiments, and evaluate and validate
the equipment and protocols that will be used as an operational
countermeasure. In addition, the contractor shall support this project's
charge to design, develop, fabricate, and test a human-rated short arm
centrifuge for space flight operations. The project is also responsible
for interfacing and supporting design concepts for a rotating module or
vehicle.

### Laboratories

Bioastronautics Human Adaptation and Countermeasures implements an
intramural program of clinical and operational research involving the
execution of discipline specific research projects, both ground and
flight based. This requires that the contractor shall support the
operation of a wide range of scientific laboratories supporting both the
operational and research activities.

#### Bone & Mineral

The contractor shall measure changes in bone that occur as a result of
space flight or bed rest and to test countermeasures to those changes.
The contractor shall support Medical Operations by providing DEXA scans
of bone density for all astronauts every 3 years, and before and after
every long-duration mission. The contractor shall support the
laboratory's NSBRI, Biomedical Engineering IPT, and Science Working
Group activities, assist in evaluation of exercise hardware proposed for
in-flight countermeasures to bone loss.

#### Cardiovascular

The contractor shall support the laboratory's medical evaluation tests
before and after flight on all crew members to help in determining
return to duty status, the monitoring of crew health, and the predicting
of individual susceptibility to post flight orthostatic intolerance.
Tests performed include operational tilt tests, in-flight Holter
monitoring, baroreflex measurements, re-entry monitoring on all
long-duration crewmembers, and changes in blood volume after flight. In
addition, the contractor shall support the echocardiography screening of
all astronaut candidates. The contractor shall support
ultrasound/echocardiography for astronaut selection, and diagnostic
ultrasonagraphy for referrals from the JSC Clinic. The Enhanced Tilt
Test will be performed as a Space Medicine Objective (SMO) on returning
long-duration crewmembers. The contractor shall support the testing of
countermeasures against post-flight orthostatic intolerance that have
been approved as a SMO for short- and long-duration crewmembers. The
laboratory's role in hardware development for the Human Research
Facility project is to provide science support and testing for an
ultrasound device, pulse oximeter, Lower Body Negative Pressure (LBNP)
apparatus, Holter monitor, continuous blood pressure device, and the
respiratory impedance plethysomograph.

#### Cellular & Molecular Research

The contractor shall perform the laboratory's ground-based and space
flight research investigations, support Space Medicine on the
Operational Renal Stone assessment, participate in countermeasures
development/validation activities, and assist in development of the
International Space Station (ISS) Human Research Facility (HRF). Studies
include investigations on the effects of space flight on the human
immune system, with a particular emphasis on viral shedding and renal
stone formation. The contractor shall support the laboratory's basic
cellular/molecular research and include:

-   Flow cytometry

-   Scanning electron microscopy,

-   Digital image analysis,

-   Molecular biology/biochemistry and

-   Fluorescence/transmitted light microscopy.

#### Environmental Biophysics

The contractor shall support the Environmental Biophysics Laboratory as
it addresses issues associated with physical factors in the space cabin
environment. Among these are inert gas composition, temperature,
humidity, and oxygen concentration. During the last decade, the primary
focus of attention has been on depressurization during EVA and the
countermeasures to prevent decompression sickness (DCS). While DCS can
be mitigated by oxygen breathing to washout nitrogen, the focus has been
on reducing time and materials need for this task. Research has focused
on the study of the magnitude and time course of DCS with and without
physical exercise. In addition, work has been performed on mathematical
models of bubble growth. The contractor shall support the tasks
associated with the investigation of methods of assessing mechanisms of
DCS.

#### Exercise Physiology Laboratory

The contractor shall support the Exercise Physiology Laboratory in its
support to the Exercise Countermeasures Project (ECP). This includes
space medicine operational support, development, evaluation and
validation for exercise protocols, and evaluations of exercise flight
equipment.

#### Muscle

The Muscle Research Laboratory currently performs a variety of
operational and basic research functions. The contractor shall support
the major purpose of the laboratory: to perform basic and applied
research in skeletal muscle biology, with special reference to
elucidating the cellular mechanisms involved in the initiation of space
flight-induced skeletal muscle atrophy.

#### Neuroscience Laboratories

The Neuroscience Laboratories conduct ground-based and space flight
research on human adaptation to space flight and re-adaptation to Earth.
The laboratory also supports space medicine monitoring and
countermeasure operational activities, countermeasures development,
validation, and development of the International Space Station (ISS)
Human Research Facility (HRF). The contractor shall support
investigations on the effects of space flight on the human nervous
system, with a particular emphasis on vestibular-autonomic,
neurosensory, sensorimotor, and perceptual functions, and on development
of countermeasures.

The contractor shall also support the Neuroscience Laboratories support
to Medical Operations by conducting the Medical Evaluation Requirement
(MER) entitled "Functional Neurological Assessment" on all long-duration
crewmembers to ensure that recovery of neurosensory control of motor
activities is sufficient for return to normal daily activities. The
assessment battery includes a standard clinical neuro-otological
assessment and a brief test of balance control.

#### Nutritional Biochemistry

The contractor shall support the Nutritional Biochemistry Laboratory's
defining of nutritional requirements for long-term space flight. The
laboratory supports the operational assessment of crewmember nutritional
status as well as ground-based and flight research. The contractor shall
support research projects such as the effects of space flight on calcium
metabolism, energy utilization, body composition, erythropoiesis, fluid
and electrolyte homeostasis, and the musculoskeletal system. The
contractor shall support the development of A Nutritional Status
Assessment that is a Medical Requirement for extended-duration
crewmembers.

#### Pharmacology

The JSC Pharmacotherapeutics Laboratory performs research and
operational activities in pharmacokinetics, pharmacodynamics,
therapeutic drug monitoring, and sleep and circadian variables of
pharmacotherapeutics. The contractors shall support the activities of
the laboratory which include research and development in the areas of
gastrointestinal, hepatic and renal physiology/function, applied
clinical pharmacology and therapeutics, chronotherapeutics, non-invasive
therapeutic drug monitoring technologies, and development of novel drug
dosage formulations and delivery systems. The contractor shall support
the overall goal of the pharmacotherapeutics laboratory to identify and
provide treatment and monitoring methods in support of medical
operations that will enhance health and well being of astronauts.

#### Psychology & Behavior

The focus of the Psychology & Behavior Laboratory is identifying
neuro-behavioral and psychosocial risks to crew health, safety and
productivity. The contractor shall investigate methods to assess
cognition, decision-making, and interpersonal behaviors, and
countermeasures to enhance both individual and team performance,
psychological health, motivation and quality of life. Leadership style,
crew composition, and national, professional and organizational cultural
issues are some of the issues that may be explored for optimizing crew
effectiveness and mission success. In addition, the contractor shall
support the exploration of relationships between psychological responses
to the stressors of long-duration space flight and other physical
systems in order to evaluate how the application of a countermeasure for
one problem may impact a non-target system.

#### Test Subject Facility & KC-135 Program Coordination

The Human Test Subject Facility (HTSF) supports both ground based and
space flight research within JSC Bioastronautics. The primary goal of
the HTSF is to provide qualified test subjects and related support for
ground-based and reduced gravity space flight research sponsored by JSC
Bioastronautics and other organizational elements at JSC, and by outside
institutions.

The contractor shall recruit, examine, qualify, schedule, and maintain
records on the human test subjects participating in ground-based studies
and reduced gravity studies sponsored by both intramural and extramural
investigators. The contractor shall coordinate all KC-135 studies
originating in Bioastronautics at JSC, and assist investigators in
coordinating support for ground-based studies conducted at JSC and at
hospitals in the Houston/Galveston area and throughout the United
States.

## Space Medicine and Health Care Systems 

The Bioastronautics mission of Space Medicine and Health Care Systems is
to:

-   Ensure a habitable and safe environment for human space flight,

-   Understand human adaptation to space flight,

-   Provide effective countermeasures,

-   Provide health care for astronauts,

-   Develop medical informatics concepts and health care delivery
    systems,

-   Develop and adapt advanced health care technologies and concepts.

These goals are achieved through the use of evidence-based medicine,
through models (Joint Commission on Accreditation of Health Care
Organizations \[JCAHO\], College of American Pathologists \[CAP\], etc.)
and by developing solutions to issues identified in the Bioastronautics
Critical Path Roadmap.

Space Medicine & Health Care Systems has responsibility for medical
operations, flight medicine, human test support, behavioral sciences,
and medical informatics. Space Medicine and Health Care Systems provides
the resident expertise on medical issues regarding human space flight.

### Medical Operations

The contractor shall support medical operational responsibilities,
including medical and laboratory planning and support for all space
flight missions, training (crews, residents, flight controllers,
biomedical engineers \[BMEs\], etc.), crew rehabilitation and the
establishment of medical care guidelines and requirements for the health
care monitoring system (including Crew Health Care System \[CHeCS\]). A
secret security clearance is required for certain tasks in this area.
The contractor shall provide medical mission support for all aspects of
human space flight, including pre-mission planning, training, in-flight
health care delivery, fitness maintenance, and post-flight
rehabilitation including:

-   Comprehensive mission medical support during all phases of space
    flight activities

-   Crew training

-   Certified, mission capable flight surgeons and biomedical engineers

-   Well-designed on-orbit medical equipment kits and procedures

-   Comprehensive support for international training and contingency
    operations.

-   Integrated individualized physical fitness and rehabilitation
    program.

### Flight Medicine Clinic

The contractor shall support the flight medicine clinic's program of
comprehensive health care to enable a healthy and productive astronaut
corps. Medical care is provided for astronauts and their families.
Services the contractor shall support include diagnostic services
(laboratory, radiographic imaging, acoustic monitoring, etc) wellness,
health stabilization, and the medical screening of astronaut applicants
at selection exams. The contractor shall support the clinic in
maintaining all medical records, including the electronic medical files.
The contractor shall support Flight Medicine Clinic responsibilities in:

-   Administrative and program support for the health and well being of
    the astronaut corps

-   Support of the annual physical assessment of retired astronauts

-   Medical care of astronaut families

-   CAP-certified and maintained laboratories for medical sample
    acquisition and analyses of all human samples for clinic operations
    and in support of missions

-   JCAHO-certified and maintained pharmacy support, including a
    registered pharmacist.

### Astronaut Medical Selection 

The flight medicine clinic and behavioral sciences sections are
responsible for astronaut medical selection. The contractor shall
support all medical aspects of the Astronaut selection process.

### Behavioral Sciences

Behavioral Sciences provides clinical and behavioral support, training,
services and products that optimize crew and mission performance. The
contractor shall support the behavioral sciences responsibilities of
Space Medicine and Health Care Systems, including the evaluation of
psychiatric risk factors (pre-flight and in-flight), crew team skills
(pre-flight and in-flight), crew cross cultural coping skills for long
duration missions, the family support program, and the
psychiatric/psychological screening of astronaut applicants at selection
exams.

The contractor shall:

-   Operate and manage the family support office that facilitates
    family, crew, and center operations and interactions.

-   Provide diversified behavioral and clinical expertise to work
    cross-discipline subspecialty tasks.

-   Execute integrated timelines through maintenance of databases that
    facilitate behavioral and performance measures and outcomes and
    provide products

-   Provide psychological crew support

-   Provide psychiatrist support of crew and families

-   Support management of international participation in the development
    of crew behavioral and performance standards

### Medical Informatics and Health Care Systems

Medical Informatics and Health Care Systems develops and integrates
database information and knowledge management techniques and
technologies utilizing appropriate data display concepts for use in
distributed operational environments. The contractor shall support the
integration of the Comprehensive Medical Information System (CMIS),
provide a relational database, support the development of a didactic
database, provide security for medical data, and support missions in the
areas of communication and data distribution.

The contractor shall support:

-   Telemedicine as an integrated component of day-to-day distributed
    medical operations.

-   Maintenance of integrated databases easily accessible to appropriate
    users.

-   Full participation in ongoing successfully re-engineered clinical
    (medical) processes

-   Development of software consistent with usability standards
    (affordance, navigation, data display)

-   Development of autonomous health care capability in day-to-day
    distributed medical operations with asynchronous communications.

### Space Medicine Equipment Requirements Definition

Space Medicine and Health Care Systems has medical oversight for
equipment requirements development for flight projects, technology
development, and clinical operational efforts and physiological
investigations to support space flight missions. The contractor shall
support:

-   Medical and biomedical participation through integrated product
    teams, in the design, development, test, and evaluation of flight
    hardware integral to Space Medicine and Health Care Systems crew
    health functions including CHeCS (Crew Health Care System).

-   Technological support for clinical operational issues

-   Implementation of technologies advancing clinical care capability

-   Outstanding library resources

## Biological Systems

The Biological Systems function in the Office of Bioastronautics is to
design, develop, test, fabricate, and implement of a broad range of
technologies and hardware in support of the state-of-the-art experiment
strategies employed by the biotechnology community. This community
includes academic, commercial, and governmental scientific investigators
who use microgravity and NASA technology to provide unique cell culture
environments.

Biological Systems conducts fundamental research in biological and
biochemical sciences with particular emphasis on health and medical
applications. Biological Systems activities support the science missions
of the Cellular Biotechnology Program and Bioastronautics Programs.

### General

The elements of the Biological Systems functions that are essential for
success are:

-   Fundamental and applied research \--

> biological, physical and chemical sciences, including cellular biology
> research, biotechnology research and advanced technology development;

-   Basic research \--

> general sciences including cell and tissue culture engineering
> research, microbial, insect and plant cell research, bioreactor
> research and development, related bioreactor technologies and
> informatics;

-   Life and environmental sciences research \--

> molecular biology, genetics, proteomics, structure and function of
> biological systems, as they relate to both the use of microgravity in
> advancing the art and understanding the effect of microgravity and
> other space and planetary stressors on living biological systems;

-   Biomedical applications \--

> three-dimensional models for new drug development and testing, genetic
> and tissue engineering of tissue for transplantation, biosignatures
> for specific stressors and diseases, models of cancer for testing new
> intervention strategies;

-   Strong, multi-disciplinary sciences base \--

> scientific, technological, engineering, computational and information
> sciences responsive to scientific issues of importance to NASA;

-   Unique experimental facilities \--

> development, maintenance and operation for use by qualified
> investigators;

-   Science, mathematics and engineering education \--

> education and training of future generations of scientists and
> engineers;

-   Technology identification \--

> of unique advances in the art arising from the performance of this
> work in areas of science, engineering, informatics, processes,
> hardware, etc; and

-   Technology transfer \--

> programs designed to move space-derived technologies into general use
> in the commercial sector.

The contractor shall develop leading-edge research facilities accessible
by academic and industrial laboratory scientists and engineers. The
contractor shall provide management and operations, technical and
scientific expertise and support with these objectives:

-   Establish and operate the Biological Systems laboratories as
    state-of-the-art research user facilities;

-   Bring basic scientific and technological capabilities to bear on a
    wide range of applied science programs to enhance the effectiveness
    of these programs; and

-   Establish and utilize alliances/collaborations with experts whose
    skills and capabilities complement the strengths of Biological
    Sciences.

### Technology Management 

The contractor shall identify the technology needs in the area of
biotechnology and develop effective, acceptable solutions. The
contractor shall integrate this effort with the NASA-established
technology management process of the National Technology Development
Program.

The contractor shall:

-   Identify and prioritize technology needs;

-   Evaluate technologies to meet those needs;

-   Survey industry, other NASA sites, and other agencies for applicable
    technologies before causing new technologies to be developed;

-   Identify opportunities for technology demonstrations and deployment;

-   Communicate and cooperate with appropriate National Technology
    Development teams;

-   Use best available technologies to address BSO needs; and

-   Seek innovative technology solutions to problems that will be more
    effective and efficient than present best available technologies.

### Biological Systems Laboratories

The Contractor shall manage, operate, and maintain the Biological
Systems laboratories and enhance their ability to function as
multi-program laboratories, providing the infrastructure and support
activities, and supporting the accomplishment of the Bioastronautics
mission.

There are several general characteristics of the Biological Sciences
laboratories. For each laboratory, the contractor shall:

-   Configure laboratory spaces per research requirements;

-   Support research activities that span the range from observational,
    fundamental/basic, to applied;

-   Support intramural and extramural research activities; and

-   Utilize the laboratory for ground research support during
    non-mission periods

### Biotechnology Facility (BTF) Project 

The Biotechnology Facility (BTF) is a continuously operating facility on
ISS that accommodates cell science and tissue engineering experiments.
The science requirements are described in JSC 28791, Science
Requirements Envelope Document for Cellular Biotechnology Research --
International Space Station.

The contractor shall develop and deliver two EXPRESS (EXpedite the
PRocessing of Experiments for Space Station) racks equipped with the
core components required for cellular biotechnology experiments. The
contractor shall provide a suite of instruments that meet the
requirements of the cellular biotechnology science community for
conducting low-gravity, long-duration biotechnology experiments
including cellular biotechnology research.

Specifications and schedules are described in task and delivery
order(s).

### Flight Definition Laboratory

The Flight Definition Cell Science Laboratory supports the development
and transition of peer reviewed investigator science to flight
experiments. The contractor shall conduct cell and tissue culture
experiments iteratively and successfully in ground-based and flight
systems. These experiments are those proposed by NASA-sponsored
NRA-recipient or NIH Principal Investigators (PI's). The contractor
shall provide the laboratory capability to support a total of two to
three flights per year. The contractor shall provide preflight, flight
and post flight operations, which culminate in the successful completion
of recovery operations and the production of post flight reports. The
reports detail the data collected and difficulties encountered during
the activity. For each experiment, the contractor shall optimize
parameters such as experiment protocols, materials, culture media
formulations, growth conditions, three-dimensional matrix substrates,
and flow conditions with respect to biocompatibility, growth rate, and
fidelity of product tissues. Once optimized, the contractor shall
evaluate equipment performance preflight and post flight and shall
conduct the experiment on-ground in the flight profile using the
experiment-specific instrumentation. During a flight, the contractor
shall simultaneously conduct control experiments on the ground.
Additionally, the contractor shall be responsible for staffing the
science console to assist with real time decisions regarding flight
experiments as they represent the PI in this capacity.

### Integration Project

The overall integration effort enables the preparation of
science-related hardware and operations in order to successfully execute
cellular biotechnology flight investigations on-orbit for multiple
venues, including the Space Shuttle and the International Space Station.

The contractor shall:

-   Maintain a strong, well-trained team consisting of systems engineers
    and individuals with multidisciplinary backgrounds responsible for
    the planning and preparation of all flight deliverables to conduct
    scientific research on-orbit;

-   Develop and coordinate all documentation required for all flight
    venues (e.g., Space Shuttle and the International Space Station);

-   Conduct the overall coordination for certification of Biological
    Systems flight hardware;

-   Be responsible for integrated testing and transportation of flight
    hardware to and from KSC;

    The contractor shall accomplish the following types of activities:

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-   Definition, consolidation and documentation of the requirements,
    capabilities, and interfaces for the Biological Systems experiments
    planned for the ISS and Shuttle. To this end, data and information
    from a wide range of sources (JSC laboratories, external
    organizations) are assembled and assimilated. Experiment
    requirements as well as experiment-specific and facility hardware
    requirements are utilized in the overall integration process. Flight
    documentation accurately reflects these requirements and is updated
    as appropriate.

-   Development of a plan to interface with both NASA managers and
    scientists in the implementation of the flight projects as well as
    to interact with outside participants. Included in this activity is
    the maintenance of current databases on changes in the ISS, ground
    support facilities and operations, and Biotechnology Express Rack
    (ER) and BTF payloads, including the implementation of appropriate
    changes in Biotechnology Express Rack (ER) and BTF schedules, goals,
    and plans.

-   Provision of integration at multiple levels to transition
    experiments, instrumentation, experiment-specific and facility
    hardware to space operation. Flight project management and
    experiment integration is provided in support of all missions.
    Mission milestones are met, and implementation plans are developed
    for support of each mission to allocate vehicle resources to each
    experiment, experiment-specific hardware, and facility support
    hardware.

-   Facilitation and coordination of all Level IV, III/II, and I tests;
    acceptance and functional tests; and integrated testing, including
    preparation of all relevant documentation. This integration activity
    requires interaction with the principal engineers (PEs), the
    Principal Investigators (PIs), and the payload developers.

-   Participation in all required safety reviews, design reviews (PDR,
    CDR, and TDR), requirements reviews, and all other meetings and
    reviews as required for each mission. Included in this are:
    development of all required documents and presentations for the
    various reviews and boards; submittal of flight specific data
    inputs; review of applicable documentation prepared by external
    organizations (e.g., Payload Integration Plan (PIP) Annexes,
    Operations and Maintenance Requirements and Specifications Document,
    Operational Maintenance Instruction (OMI), Flight Data File (FDF),
    etc.); interfacing with the PI, crew, and mission operations
    personnel to develop in-flight procedures; development of plans and
    schedules to coordinate crew training for each proposed flight
    investigation; and resolution of crew questions and issues.

### Sensors and Controls Technology Development (SCTD)

The Biological Systems Office requires sensors and controls technologies
for monitoring and regulating cell and tissue cultures during long-term
operation of bioreactor systems during Principal Investigator
experiments aboard ISS. The Sensors and Controls Technology Development
(SCTD) Project's mission is documented within Biotechnology program's
strategic mission plans and is updated as necessary within an SCTD
institutional plan. In support of Bioastronautics Program and Biological
Systems Office organizations, the mission of the SCTD Project includes
the following: maximizing the automatic operation of on-orbit cell
culture and tissue engineering experiment hardware by research into and
development of, technologies to monitor the critical metabolic
parameters within bioreactor cell culture nutrient media, and to adjust
those same parameters where necessary to minimize the use of
consumables, minimize generation of waste products, and maintain a
physiological environment for the cells and tissues under study.

The contractor shall develop technologies to monitor the critical
metabolic parameters within bioreactor cell culture nutrient media and
to adjust those same parameters where necessary to minimize the use of
consumables, minimize generation of waste products, and maintain a
physiological environment for the cells and tissues under study. A key
final outcome of this activity is to maximize the automatic operation of
on-orbit cell culture and tissue engineering experiment hardware as
mandated by the Biological Systems Office

The contractor shall provide:

-   Well planned and executed research and development activities;

-   Successful publication of research findings;

-   A multi-disciplinary project team that can address all technological
    issues and demonstrates an understanding of relevant technological
    and scientific fields, including prior research and
    state-of-the-art;

-   Successful demonstration of technologies in relevant experimental
    environments, including cell-free and cell-based bioreactor systems;

-   Familiarization with the state-of-the-art in pertinent technical
    areas and with technologies under active investigation at
    universities, commercial labs or other federal sites;

-   Establishment of the project group as the center of expertise for
    NASA in bioreactor, cell culture and tissue engineering sensor and
    control technologies.

### Outreach and Education

The contractor shall plan and implement outreach and education
activities including special projects, website and database development
and maintenance, demonstrations, displays, seminars and presentations.
The contractor shall develop program materials including various program
publications (e.g., brochures, multi-media products, exhibit materials).
The contractor shall provide various exhibits, some long-term and
continuing (e.g., website, database), others short duration and
requiring a quick turn-around for a specific task/audience (e.g.,
exhibit/brochure development and display for a particular conference).

The contractor shall provide presentations suitable for specific
audiences (e.g., high school teachers and students; 7^th^-10^th^ grade
students participating in Summer Science Camps; 6-8^th^ grades girls
participating in the "Expanding Your Horizons in Math and Science
Program"; local and national scientific meeting audiences; congressional
members and staff; dignitaries; various high-ranking public officials).

The contractor shall interface with international and national space
agencies, institutes and centers. This includes Russia, Japan,
Switzerland, Italy, Brazil, Germany, Sweden, France, and Australia. The
contractor shall also interface with investigators. This includes
investigator outreach at workshops, meetings, and symposia, and one
BSO-sponsored scientific meeting per year, inviting as many as 100
investigators.

### Bioreactor Research Support (BRS) Project

The Bioreactor Research Support (BRS) project familiarizes
investigators, both current and potential, in the use of bioreactor.

The contractor shall provide formal instruction, workshops, and onsite
use of the reactors.

The contractor shall implement the capability to perform cutting edge
genomics and proteomics analyses to support research investigations. In
addition, the contractor shall support the activities of NASA in-house
investigators to develop scientific protocols and technology leading to
the successful pursuit of these peer reviewed studies.

The BRS develops cooperation in bioastronautics initiatives with NASA
centers, NSBRI, NIH/NCI and with the major structures within
Bioastronautics Initiatives Office.

The contractor shall:

-   Establish and maintain interaction with PIs on research projects
    funded by NASA (through NIH, industry, NRA, NSBRI), or funded by
    NIH, NCI and by the National Science Foundation in order to advocate
    priorities for fundamental and applied research in compliance with
    the JSC Bioastronautics Critical Path Roadmap and NRC (National
    Research Council) recommendations.

-   Assist in interpretation of the biological effects of space-related
    factors on biological systems and in developing effective
    countermeasures suitable in long-term space missions.

-   Establish and maintain interdisciplinary exchange of ideas and
    scientific information related to space exploration with other NASA
    centers and institutes.

-   Consult and technically support the use of bioreactor technology to
    funded investigators in their studies.

The Bioreactor Research Laboratory supports the activities of the
Cellular Biotechnology laboratory by conducting basic and applied
research and by fostering the involvement of intramural and extramural
research investigators.

The contractor shall accomplish activities similar to the following in
support of BRS:

-   Collecting and analyzing data in order to prepare research reports,
    setting up and maintaining cell culture systems and test equipment,
    transporting equipment and biological samples to project related
    laboratories, performing literature reviews, generating manuscripts
    and presentations for scientific meetings.

-   Development of three-dimensional transgenic cell models using
    co-cultures of two cell types. The cell models utilize a test system
    capable of quantifying mutation and chromosome aberrations in the
    two cell types. This project serves as a basis for the development
    of a three dimensional, mutation system to quantify genotoxic
    effects in space and to analyze the genotoxic damage caused by
    high-LET and low-LET radiation.

-   Preliminary experiments from an in vitro muscle model research
    project that showed that three-dimensional muscle models of various
    shapes and sizes could be constructed in the NASA-designed
    bioreactor and also at unit gravity

-   A surface electromyography (EMG)-based in vivo muscle model has been
    developed that is capable of predicting muscle performance/fatigue
    early during exertion of the erector spinae back muscle during
    dynamic repetitive exercise

##  Mission and Project Management and Program Integration

Bioastronautics Mission and Project Management and Program Integration
defines, develops, and manages successful science missions, programs,
and projects for JSC and NASA. The successful implementation of these
missions and projects promotes the effective and efficient use of flight
resources ensuring crew health, safety, and optimum performance.
Bioastronautics provides science payload mission management,
integration, and operations functions for utilization of Shuttle and
International Space Station (ISS) accommodations, systems, and
facilities, and manages the development and flight of human biomedical
experiments.

NASA has established mission and payload management processes that
provide the framework to successfully integrate and operate science
payloads on Shuttle, ISS, or other vehicles. This contract provides
planning, organizing, managing, and controlling of those activities
required to integrate experiments or facilities into a total payload
complement for a shuttle mission or ISS increments.

The contractor shall develop productive working relationships with a
wide range of organizations and people, including NASA Headquarters,
other NASA centers, Shuttle, ISS, or other program offices, payload
developer organizations, Principal Investigators (PIs), and
international partners.

### Mission Management

The mission management responsibilities for a given flight vary in scope
depending upon the particular mission assigned by Bioastronautics or by
NASA Headquarters organizations. The contractor shall support the
following mission management tasks including:

-   Mission feasibility studies and payload accommodation assessments;

-   Development and maintenance of mission or payload manifests;

-   Integration of mission cold stowage requirements;

-   Development of payload requirements documents;

-   Development and maintenance of a mission master schedule;

-   Development of programmatically required payload integration plans
    and annexes;

-   Design and development of integration hardware, or payload bay
    carrier hardware;

-   Coordination and development of required flight and ground payload
    safety data packages, support of the flight and ground payload
    safety reviews, and development and verification of hazardous
    material summary tables;

-   Coordination and development of crew training procedures, review and
    input to mission operations documents and flight data files, and
    coordination and participation in mission simulations;

-   Definition of payload ground processing requirements, development of
    payload destow plans and requirements, coordination and support of
    payload processing activities with the KSC launch site, and prime
    and backup landing sites;

-   Verification and certification of payload flight readiness;

-   Development of mission documents and console books, and
    participation in real-time flight operations; and

-   Documentation of mission results.

### Project management

The project management, development, and operation of Bioastronautics
flight and ground projects, facilities, and experiments require a
well-integrated and coordinated approach. Mission and Project Management
develops and manages Human Life Sciences (HLS) flight research
experiments that satisfy science requirements, meet NASA programmatic
and safety requirements, and are delivered on time and within budget.
This requires balancing the resource requirements for each candidate
experiment versus the resource availability for the mission or
increment. Depending on the scope of the individual project, the
contractor shall support project management tasks including:

-   Definition and development of the HLS science payload complement of
    a flight or increment, and management of the complement through all
    phases of the mission: preflight, in-flight, and postflight;

-   Overall project and science management, integration, and
    coordination of the project or facility;

-   Resource definition and tracking;

-   Management, scheduling, development, and control of facility and
    experiment-unique hardware development projects;

-   Coordination of international partner hardware development,
    including the definition of interface requirements;

-   Development and maintenance of master schedules in support of
    dynamic ISS flight and increment planning;

-   Development of operations and training documentation, and support of
    simulation and real-time console support activities;

-   Provide science, integration, training, verification, and operations
    related deliverables and services for the HLS payload complement
    assigned to an ISS increment;

-   Provide guidance to the selected Principal Investigators in
    developing and maintaining an experiment requirements document;
    coordinate and conduct experiment reviews, publish the experiment
    requirements document, close all action items after the experiment
    reviews, and represent the PIs at review and control boards;

-   Support and provide science expertise at experiment design reviews,
    Investigator Working Groups (IWG), PI meetings, and represent
    science to the ISS and Space Shuttle Programs;

-   Develop a plan for implementing Baseline Data Collection activities
    at JSC and remote sites;

-   Develop and maintain ground data facilities used to support
    multi-Increment real-time HRF payload operations. The JSC
    Telescience Support Center (TSC) will be the gateway where a remote
    user and PIs can access ISS experiment information over the
    Internet.

-   Technical services, including Integrated Planning System (IPS),
    library services, and web site maintenance;

-   Documentation of the payload or experiment results.

### Shuttle and Station Flight Operations Support

Mission and Project Management provides support to the Space and Life
Sciences Directorate (SLSD) in various areas for Space Shuttle and ISS
flights and increments. The contractor shall perform the following:

-   Provide overall coordination of the SLSD Certificate of Flight
    Readiness (CoFR) process, and support the ISS and Shuttle CoFR
    processes,

-   Review, evaluate and track flight-specific change requests (CR) or
    programmatic documents for impacts to SLSD,

-   Maintain cognizance of and document SLSD activities and issues by
    flight or increment,

-   Develop and maintain flight operations and mission data book,
    in-flight anomaly log, and lessons-learned report for each mission,

-   Provide mission operations support and/or on-call support,

-   Participate in, prepare data, and maintain schedules for flight
    program, discipline, or programmatic meetings,

-   Update and publish the SLSD Contingency Action Plan, and

-   Perform special scientific, technical, or programmatic studies as
    requested by SLSD.

### Science Management and Technology Integration

Bioastronautics Science Management and Technology Integration functions
are to provide science management oversight, coordination, and
integration for the programs and projects in the Office of
Bioastronautics.

Science Integration

The contractor shall prepare the comprehensive flight manifest for
Bioastronautics Science. The contractor shall maintain of the Flight
Master Schedule, assess the compatibility of flight elements, provide
additional mission unique assessments, and provide support for regular
presentations of the Bioastronautics integrated flight manifest to the
Bioastronautics Flight Activities Control Board. The contractor shall
assess, propose revisions, and maintain the Bioastronautics Critical
Path Roadmap.

Life Sciences Data Archive (LSDA)

The contractor shall develop and implement a plan for incorporating new
data into the existing archive and upgrade archive hardware and software
as needed to accommodate the ISS and other archive data. The contractor
shall implement postflight reporting and archiving for ground-based
research including a historical archive of selected analogs to space
flight ground-based experiments prioritized with relevance to
Bioastronautics Critical Path Roadmap or other requirements documents as
identified. The contractor shall develop data preservation standards for
maintaining data in a recoverable form.

The contractor shall build an infrastructure for Life Sciences Data
Archive (LSDA) attributable data that allows Principal Investigators
(PIs) to access their own data and allows for the data mining
(examination, analysis, and interpretation) and integration of research
and medical data by designated groups or individuals. The contractor
shall convert Russian database information to the LSDA format. The
contractor shall archive data from Countermeasures Evaluation Validation
Project (CEVP) and the Detailed Supplemental Objective (DSO) program
archive.

Bioastronautics Requirements Management

The contractor shall identify and collect Bioastronautics requirements
and prepare and maintain project management documentation. The
contractor shall revise existing documents and prepare new documents
when needed for revised or additional requirements. Existing documents
include the Medical Operations Requirement Document (MORD),
Bioastronautics Data book, Critical Path Roadmap, and the Man-Systems
Integration Standards (MSIS). Others may be identified as this effort
progresses. Additionally, the contractor shall implement a relational
database which links and cross-references requirements and ongoing
research activities.

Advanced Technology Integration

The contractor shall identify the most critical technology needs for
long-duration space flight and identify potential technology development
resources for their development. The goal of this effort is
collaboration. The contractor shall create opportunities for NASA
experts in various Bioastronautics disciplines to work with skilled
technology developers in government, academia, and the military. The
contractor\'s work shall be a balance between assessment of technology
needs, capabilities, and emerging solutions and facilitation of
researcher-developer collaborations.

## Bioastronautics Flight Hardware (BFH)

The Space and Life Sciences and Engineering Directorates at JSC
collaborate on the overall development, production, certification, and
deployment of Bioastronautics Flight Hardware. The mission of the
Bioastronautics Flight Hardware process is to provide flight hardware
products and services for Bioastronautics flight projects. The nature of
the scientific functions of the Bioastronautics Flight Hardware products
and services are generally new and vary widely from project to project
and within projects to meet the technical requirements of the biological
and medical sciences.

The Bioastronautics Office, the National Space Biomedical Research
Institute, and Principal Investigators from academia, government, and
industry from around the world are sources of the flight project
concepts and their associated science and medical requirements. The
government coordinates these sources to establish and refine the science
and medical requirements. When requested, the contractor shall assemble
requirements definition documentation to inform a decision by the
government on whether to proceed with a flight hardware project.

The government issues an IDIQ Task Order for every BFH project or
product. The Task Order may be cost reimbursable or fixed price. Prior
to the issuance of a task order, the government may request a quote for
the delivery of the BFH project or product. The government reserves the
right to select a source other than this contract to complete a BFH
project or product.

Upon issue of a task order, the contractor develops, produces, certifies
and deploys flight hardware and software products for the project.
Alternatively, the government may task the contractor to provide
specific components or subsystems needed for a flight hardware and
software project.

The requirements, quality standards, and project management procedures
for each BFH project or product are specified in its Task/Delivery
Order. Usually they are specified by reference to the JSC QMS procedures
and work instructions. The engineering requirements for space flight and
the space flight vehicles applicable to Bioastronautics flight hardware
projects are relatively mature and are found in existing NASA
documentation. The management processes for development of
Bioastronautics flight hardware are documented in the JSC QMS and are
based on well-established flight hardware processes. When the
Bioastronautics Flight Hardware Project requires the use of specific
government facilities and capabilities, the signed Task Order authorizes
use of those government facilities and capabilities.

The essential performance requirement for Bioastronautics Flight
Hardware products and services is to meet or exceed all customer
requirements for safety, cost, performance, and schedule.

The contractor shall provide hardware and software products for
Bioastronautics Flight Hardware projects. These products include
medical, biological, chemical, mechanical, fluid, electrical and
electronic hardware, and associated software.

Science investigators and biomedical researchers define science
measurement requirements. These are the requirements necessary to meet
the scientific objectives. In some cases the flight hardware project
starts with only these requirements defined. In other cases unique
scientific hardware exists that must be integrated into a flight
hardware system. In still other cases, the project may provide
commercial type capabilities aboard a flight vehicle. The flight
vehicle, flight vehicle systems, or other flight hardware and software
may be required to meet the Science Measurement Requirements. The
contractor shall comply with the requirements of JPG 8500.4, the
Engineering Drawing System for the development of Flight or GFE hardware
and software.

The contractor shall produce products that meet flight hardware and
vehicle requirements. Products also support the flight hardware process
and the relevant Program Office(s) processes for the vehicle(s). These
are defined within each Task Order. The contractor shall be responsible
for gathering and maintaining the full set of scientific measurement
requirements, flight environment design requirements, and program
requirements. The contractor shall comply with JPG 8080.5, JSC Design
and Procedural Manual in the development of Flight and GSE hardware.

### Types of projects and products 

Types of Hardware and Software

-   Bioastronautics Flight Hardware and Software

-   Qualification Hardware for Bioastronautics Flight Hardware and
    Software

-   Ground support equipment for Bioastronautics Flight Hardware and
    Software

-   Bioastronautics Flight Hardware Trainers

Types of Engineering Activities

-   Engineering Design and Development

-   Testing, verification, and certification

-   Sustaining engineering activities \[hardware resupply,
    refurbishment, mission hardware support activities, failure
    analysis, repair, operating procedures\]

-   Flight Hardware Requirements Survey, Assessment, and Consolidation

-   Engineering, Quality, and Safety Analyses

Types of Data and Design Documentation

-   Project Technical Requirements Specification

-   Design review documentation

-   Safety review documentation

-   Test, verification, and certification data

-   Management Documentation

-   Analysis Data Products

Table 2.6-1. Types of projects and products

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### Use of Off-The-Shelf Hardware

The contractor shall use off-the-shelf (OTS) products wherever such
products meet the science, technical, and engineering flight environment
requirements, in accordance with work instruction EA-WI-016,
Off-the-Shelf Hardware Utilization in Flight Hardware Development.
Off-the-Shelf equipment is defined as hardware and/or software
components that have an existing extensive heritage of use. Categories
of OTS equipment include:

-   Commercial OTS -- A hardware and/or software component that was
    designed, manufactured, and certified for a commercial application.

-   Military OTS -- A hardware and/or software, manufactured, and
    certified for a military application.

-   Space OTS -- A hardware and/or software component that was designed,
    manufactured and certified for a space application.

-   NASA OTS -- A subset of Space OTS where a hardware and/or software
    component was designed, manufactured and certified for a NASA space
    application.

### Applicable Documents for Bioastronautics Flight Hardware 

The Applicable Documents List (Section J) for flight hardware is the
primary set of the required documents applicable to Bioastronautics
Flight Hardware. These documents contain acceptance criteria for the
quality and reliability needed in the development and production of
quality flight hardware. These documents are routinely updated. These
and additional documents will be listed in individual Task/Delivery
Orders for science measurement requirements and additional flight
hardware or flight vehicle requirements.

The ongoing space programs and science programs are dynamic and
knowledge is being documented routinely. The contract shall maintain an
effective awareness of available and relevant NASA documentation, shall
identify all sources of requirements that are applicable to assure
project success, shall maintain surveillance of changes to applicable
requirements, shall identify and recommend resolutions to conflicts
between existing requirements.

NASA has an extensive web based documentation system. The contractor
will be provided access to NASA\'s network. It allows access to the
Scientific & Technical Information Center that leads to the current
versions of the NASA, Military, and Industry Standards and
Specifications. It also allows access to the program, vehicle office,
engineering, quality, reliability, and safety organizations requirements
documentation for JSC and MSFC found in the Quality Managements Systems
Documentation and Configuration Management Systems Documentation of
each.

### Sources for Reference Processes for Bioastronautics Flight Hardware 

Generally, Bioastronautics Flight Hardware will be developed,
fabricated, and processed for flight using established Engineering,
Quality, and Safety, Reliability and Mission Assurance Flight Hardware
processes. These processes have been documented within a number of Work
Instructions that apply to NASA JSC Organizations. These Work
Instructions describe the full objectives of the activities undertaken
in the development of a major Flight Hardware project and defines the
deliverables needed throughout the project. Many of these deliverables
may be requested within a Bioastronautics Flight Hardware Task Order.
Flight and GFE Hardware shall be designed and developed in accordance
with JPG 8080.5, "JSC Design and Procedural Standards Manual".

### BFH Safety, Reliability, Maintainability, and Quality Assurance (SRM&QA) 

**Safety and Mission Assurance (S&MA) Responsibility**

The contractor shall provide all SRM&QA functions for flight hardware
and software products developed and manufactured at the contractor's
off-site facilities, through final acceptance and delivery to the
Government. The JSC SRM&QA organization will provide the Quality
Assurance, Quality Engineering, and Software Quality Assurance services
within JSC onsite facilities, where space flight hardware, software, and
ground support equipment are processed.

The contractor shall perform S&MA assessments and provide S&MA products
in accordance with the specified NASA program S&MA requirements for
flight hardware and software.

Acceptance Data Package

The contractor shall provide an Acceptance Data Package (ADP) for each
flight hardware or flight software end item, as required by Delivery
Order. The ADP shall reflect the status of the hardware/software at the
time of acceptance and shall be delivered concurrently with the
hardware/software end item. Content shall be in accordance with the
Acceptance Data Package (ADP) DRD.

S&MA Certification

The contractor shall document certification for hardware and software
using the Certification & Acceptance Requirements Document (CARD) DRD.

The contractor shall document the results of the hardware and software
certification using the Certification Data Package DRD

Hazard Control

The contractor shall verify hazard controls for GFE are identified,
implemented, and reported to the JSC Safety and Mission Assurance Review
Team (SMART). Hazard controls for payload hardware shall be processed
through the Payload Safety Review Panel.

In addition, the following products shall be developed in accordance
with the DRDs for: Certification and Acceptance Requirements Document
(CARD), Certification Data Package, Government Certification Approval
Request (GCAR), Safety Analysis Report (SAR), and Hazard Report (HR).

Limited-Life Items List

The contractor shall use the Limited-Life Item List DRD to document
limited-life items.

Nonconformance Record

The contractor shall establish and implement a system that documents all
nonconformances in a consistent manner, and ensures the necessary data
is included and available as specified in the DRD.

Risk Assessment Executive Summary Report

The contractor shall provide an overview of the safety critical aspects
of the hardware and software using the Risk Assessment Executive Summary
Report (RAESR) DRD.

System Safety Program

The contractor shall develop, plan, and implement an independent safety
program to assure that hazards and their consequences are identified,
evaluated, and controlled throughout all phases of the program in
accordance with NSTS 1700.1 (Volume 1B), NASA Safety Policy and
Requirements Document. As part of this program, the contractor shall
develop a System Safety Program Plan as specified in the DRD. The
contractor shall use the Safety and Health Plan DRD and other safety
related DRDs to develop the System Safety Program Plan.

System Safety Requirements

The contractor shall meet all applicable safety design and information
requirements as defined in the project requirements document identified
for each subsystem.

-   For Space Shuttle: The contractor shall perform and update safety
    analyses in accordance with the Space Shuttle GFE Safety Analysis
    Report (SAR) and Hazard Report (HR) DRD.

-   For Space Station: The contractor shall perform and update safety
    analyses in accordance with the Space Station Hazard Report
    (HR)/System Descriptions DRD.

-   For Payloads: The contractor shall perform and update payload safety
    analysis in accordance with the Payload Safety Data Package DRD.

Flight Hardware Failure Modes and Effects Analysis and Critical Items
List

The contractor shall prepare, maintain, and submit Failure Modes and
Effects Analysis (FMEA) and Critical Items List (CIL) and support
program reviews as required by NSTS 22206 for Space Shuttle and SSP30234
for Space Station.

-   For Space Shuttle: The contractor shall conduct and prepare FMEAs
    and CILs in accordance with the Space Shuttle GFE Failure Modes and
    Effects Analysis (FMEA) and Critical Items List (CIL) DRD.

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-   For Space Station: The contractor shall conduct and prepare FMEAs
    and CILs in accordance the Space Station GFE Failure Modes and
    Effects Analysis (FMEA) and Critical Items List (CIL) DRD.

Reliability and Analysis

The contractor shall document required reliability and maintainability
analysis in the Space Station Reliability & Maintainability Predictions
Report DRD.

The contractor shall make available upon request all component and part
data used to develop the Mean Time Between Failures (MTBF). Ground
support equipment MTBFs shall be developed in contractor format and
available upon request.

Space Station Reliability and Maintainability Predictions Report

For Space Station, the contractor shall use the Space Station
Reliability and Maintainability Predictions Report DRD to status
quantitative R&M characteristics of Space Station functions,
capabilities, and equipment.

Failure Detection, Isolation, and Recovery (FDIR) analysis shall be
performed and submitted in accordance with the Space Station Reliability
and Maintainability Predictions Report DRD.

# List of Acronyms: {#list-of-acronyms .unnumbered}

ADP Acceptance Data Package

AG Artificial Gravity

AHST Advanced Human Support Technology

ALERT Acute Launch Emergency Reliability Tip

ANSI/ISO/ASQ American National Standard Institute/International
Organization for Standardization/American Society for Quality

BCPR Bioastronautics Critical Path Roadmap

BFH Bioastronautics Flight Hardware

BME Biomedical Engineer

BR&C Biomedical Research and Countermeasures

BRS Bioreactor Research Support

BSO Biological Systems Office

BTF Biotechnology Facility

CAP College of American Pathologists

CARD Certification and Acceptance Requirements Document

CDR Critical Design Review

CEVP Countermeasures Evaluation and Validation Project

CHeCS Crew Health Care System

CIL Critical Items List

CMIS Comprehensive Medical Information System

Code U Office of Biological and Physical Research

Code M Office of Space Flight

CoFR Certificate of Flight Readiness

COTS Commercial Off The Shelf

CPHS Committee on the Protection of Human Subjects

CR Change Request

DCS Decompression Sickness

DEXA Brand name

DRD Data Requirements Description

DRL Data Requirements List

DSO Detailed Supplemental Objective

DTO Detailed Technical Objective

ECP Exercise Countermeasures Program

EEE Electrical, Electronic, and Electromechanical

EMG Electromyography

EMS Environmental Management System

EO Executive Order

EP Exercise Physiology (lab)

ER Express Rack

EVA Extravehicular Activities

EVPMS Earned Value Performance Management System

EXPRESS EXpedite the PRocessing of Experiments for Space Station

FAR Federal Acquisition Regulation

FDIR Failure Detection, Isolation, and Recovery

FDR Flight Data File

FMEA Failure Modes and Effects Analysis

GCAR Government Certification Approval Request

GFE Government Furnished Equipment

GIDEP Government and Industry Exchange Program

GSI Government Source Inspection

HACO Human Adaptation and Countermeasures Office

HEFO Habitability and Environmental Factors Office

HLS Human Life Science

HRF Human Research Facility

HR Hazard Report

HTSF Human Test Subject Facility

IDIQ Indefinite Delivery Indefinite Quantity

IM&TE Inspection, Measuring, and Test Equipment

IPS Integrated Planning System

IPT Integrated Product Team

ISO International Organization for Standardization

ISS International Space Station

IT Information Technology

IWG Investigator Working Group

JCAHO Joint Commission Accreditation of Health Care

Organizations

JHB JSC Handbook

JPD JSC Policy Directive

JPG JSC Procedures and Guidelines

JSC Johnson Space Center

KSC Kennedy Space Center

LBNP Lower Body Negative Pressure (suit)

LET Linear Energy Transfer

LOE Level of Effort

LSDA Life Science Data Archive

MER Medical Evaluation Requirement

MORD Medical Operations requirements Document

MPMO Mission and Project Management Office

MRID Medical Requirements Integration Document

MSCL Measurement Standards and Calibration Laboratory

MSFC Marshall Space Flight Center

MSIS Man-Systems Integration Standards

MTBF Mean Time Between Failures

NASA National Aeronautics and Space Administration

NCI National Cancer Institute

NIH National Institute of Health

NPG NASA Procedures and Guidelines

NRA NASA Research Announcement

NRC National Research Council

NSBRI National Space Biomedical Research Institute

NSTS National Space Transportation System (Shuttle)

NT-CWI Common Work Instruction originating in NT (SRM&QA)

OMI Operational Maintenance Instruction

OTS Off the shelf

PDR Preliminary Design Review

PE Principal Engineer

PI Principal Investigator

PIO Program Integration Office

PIP Program Integration Plan

PRACA Problem Reporting and Corrective Action

PV/S Pressure Vessels/Systems

QARC Quality Assurance Record Center

QMS Quality Management System

RAB Registration Accreditation Board

R&M Reliability and Maintainability

RAESR Risk Assessment Executive Summary Report

RITF Receiving Inspection and Test Facility

S&MA Safety and Mission Assurance

SAR Safety Analysis Report

SCTD Sensors and Controls Technology Development

SLI Space Launch Initiative

SLSD Space and Life Sciences Directorate

SM&HCSO Space Medicine and Health Care Systems Office

SMART Safety and Mission Assurance Review Team

SMO Space Medicine Objective

SOW Statement of Work

SQA Software Quality Assurance

SRM&QA Safety, Reliability, Maintainability, and Quality Assurance

SSP Space Station Program

T/DO Task / Delivery Order

TDR Technical Design Review

TSC Telescience Support Center

WBS Work Breakdown Structure