**Supplementary Instructions**

**for Native American Research Centers for Health (NARCH V) Applications
in 2008**

Since the NARCH application can be quite complex, please follow the
instructions for the PHS 398 application except where noted below.
Please note that [it is recommended]{.underline} to use the most current
version of application forms and instructions for the PHS form 398
(Revised 11/2007). Use of the electronic versions, downloaded directly
from NIH, is strongly encouraged. These can be found at:
<http://grants.nih.gov/grants/funding/phs398/phs398.html>. However, the
previous version of the PHS 398 (Revised 9/2004) will also be accepted
for the NARCH V cycle.

**SECTION I -- PHS 398 GENERAL INFORMATION REQUIREMENTS**

I.  **FACE PAGE** (Use Form PHS 398 Face Page) (Form Page 1).

**Item 1. Title of Project.** The title should be related to the overall
structure of the program (e.g. NARCH V Program at\_\_\_\_\_\_\_\_\_Tribe
and \_\_\_\_\_\_\_\_\_University) and not to a particular research or
student development project.

**Item 2. Response to Specific Request for Application or Program
Announcement**. Check the box marked "YES". Under "Number" type in "[NOT
GM-08-115]{.underline}" and under "Title" type in the words "[Native
American Research Centers for Health **(NARCH) V**]{.underline}".

II. **DESCRIPTION, PERFORMANCE SITES AND KEY PERSONNEL** (Use Form PHS
    398 Form Page 2). In preparing the abstract of the proposed program,
    in addition to the instructions given in Form PHS 398, outline the
    overall program goals and objectives, anticipated outcomes and how
    the proposed research projects relate to achieving these objectives
    and the goals of the NARCH Program.

III. **TABLE OF CONTENTS** (Form Page 3)

Reviewers will find the application easier to read if the pages in the
NARCH applications are arranged in the order shown in the *Sample* Table
of Contents below. Pages should be numbered consecutively at the bottom
throughout the entire application; i.e., if the last page of one project
is page 125, then the first page of the next project should be page 126.
Do **[not]{.underline}** use suffixes for page numbers, such as 5a, 5b.

> ***SAMPLE***
>
> TABLE OF CONTENTS
>
> [SECTION 1 PHS 398 GENERAL INFORMATION REQUIREMENTS]{.underline}

I.  FACE
    PAGE.......................................................................
    1

II. DESCRIPTION, PERFORMANCE SITES AND PERSONNEL.................... 2

III. TABLE OF
     CONTENTS......................................................\.....
     3

IV. ADMINISTRATIVE
    BUDGET.................................................... 4

V.  OVERALL SUMMARY
    BUDGET................................................ 5

VI. BIOGRAPHICAL SKETCH OF NARCH DIRECTOR............................ 6

VII. OTHER SUPPORT (FOR NARCH DIRECTOR ONLY).......................... 7

VIII. INSTITUTIONAL SETTING AND GENERAL PLAN............................
      8

> [SECTION 2 (2a., 2b., 2c., etc.) -- FORMAT FOR EACH RESEARCH
> PROJECT/PILOT]{.underline}

IX. FACE
    PAGE.....................................................................
    \_\_

X.  DESCRIPTION, PERFORMANCE SITES AND PERSONNEL........ \_\_

XI. TABLE OF CONTENTS (Use Form PHS 398)............................
    \_\_

XII. ADMINISTRATIVE BUDGET..............................................
     \_\_

XIII. OVERALL SUMMARY BUDGET.......................................\...
      \_\_

XIV. BIOGRAPHICAL SKETCH OF PRINCIPAL INVESTIGATOR \...... \_\_

XV. OTHER SUPPORT (FOR PRINCIPAL INVESTIGATORS ONLY)\... \_\_

XVI. INSTITUTIONAL SETTING AND GENERAL PLAN.................. \_\_

> XVII\. PROJECT CHECKLIST (Use Form PHS
> 398)............................. \_\_
>
> [SECTION 3 CENTER CHECKLIST (Use Form PHS
> 398)]{.underline}......................... \_\_

IV. **OVERALL BUDGET SUMMARY and**

V.  **ADMINISTRATIVE/CORE BUDGET (if separate)**

General Budget Instructions:

NARCH proposals must submit two types of grantee budgets:

> \(1\) Overall program summary Budget
>
> \(2\) Budgets for each of the projects.

The grantee may, if desired, also submit an administrative/core budget
separately from the overall program summary budget. In that case the
administrative/core budget can be structured just like an individual
project budget. If a separate budget is not used for administrative/core
functions, then these costs should be itemized and included in the
overall program summary budget.

Each budget must consist of two separate parts:

> \(1\) Detailed Budget for the First 12-Month Period (PHS 398 Form Page
> 4) and
>
> \(2\) Budget for the Entire Proposed Project Period (PHS 398 Form Page
> 5).

Place the overall program summary budget (2 pages), followed by the
administrative/core budget pages (if applicable, 2 pages), after the
page showing the table of contents. The budget pages for individual
research projects, pilot research projects and training projects (each 2
pages) are placed after the table of contents of each individual
project. If subcontractors are participating in a project, their budgets
should also be submitted using PHS 398 form pages 4 and 5, with
justifications, and attached immediately following the project budget
pages. Subcontractor direct costs should be copied to the project budget
form page 4 as

"Consortium/contractual costs \| Direct Costs." The subcontractor's
indirect costs go next to "Consortium/contractual costs \| Facilities
and Administrative costs" near the bottom of Form page 4.

Label each budget page in the [Top right hand corner]{.underline} (i.e.,
"Administrative/Core Budget" "Overall Program Summary Budget", "Project
\# - Name of Project Principal Investigator" or Project \# - Name of
Subcontractor). Appropriate positioning of these labels is shown in the
"NARCH Budget Workbook" spreadsheet tool.

Follow the budget guidelines in Form PHS 398 instructions. The budget
items should be described in detail, and justify the need for all
requested items. Do **NOT** assume that the need is obvious.
Subcontractor total direct costs should be copied to the project budget
form page 4 as "Consortium/Contractual Costs." The subcontractor's
indirect costs go next to "Facilities and Administrative costs" near the
bottom of Form page 4. These subcontractor costs should be added to the
grantee's "Subtotal direct costs for initial budget period" to arrive at
the "Total direct costs for initial budget period," at the bottom of
form page 4. This amount should be transferred to item 7a on the project
face page. The grantee's negotiated indirect rate should then be applied
to the applicable base and added to item 7a to get item 7b. This should
be the total amount needed from the government for the grantee to
accomplish the project for the first year, including all indirect costs.
The sum of the 7a's from each project, added to all other grantee direct
costs (from the Administrative/Core and/or Overall Summary Budgets)
should equal total direct costs (7a) on the PHS 398 face sheet for the
NARCH. This total of the individual direct costs is limited to
\$1,000,000 in the first year. Formulas consistent with these
instructions have been built into the "NARCH Budget Workbook"
spreadsheet tool, both to further illustrate the logic of the required
budget structure and for the applicant to use as needed.

An overall summary of the estimated costs for each project's entire
project period must be included on the Form pages 5. Significant changes
from one year to the next should be explained (e.g., Lab work all
finished by year 3, new staff needed from 3^rd^ year on, subcontracted
work finished in 2^nd^ year, etc.). The total direct and indirect costs
for the entire project period should be entered under item 8 on the
project face page, as they were under item 7 for the first year costs.
The applicable bases and indirect rates should be reflected on the
project checklist and this should be consistent with the costs for the
entire project period, which should be calculated on the project's form
page 5 and copied to item 8 on the project face page.

VI\. **BIOGRAPHICAL SKETCH FOR NARCH DIRECTOR** (Use PHS 398 Form Page)

VII. OTHER SUPPORT (FOR NARCH DIRECTOR ONLY) (Use "Other Support"
     format.

> There is no \"form page\" for other support. Information on other
> support should be provided in the *format* shown at:
> <http://grants.nih.gov/grants/funding/phs398/othersupport.pdf> , using
> continuation pages as necessary.)

VIII. **INSTITUTIONAL SETTING AND GENERAL PLAN** (Use PHS 398
      Continuation Pages)

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A.  **[Description of the Partnership]{.underline}**

> (Do not exceed four pages, not including tables and graphs.)

The information below must also be provided in the application. This
information is necessary for determining the appropriateness of the
environment for a NARCH program.

1.  Describe the origins and development of the collaboration through
    the submission of the application.

2.  Briefly summarize, in tabular Form, for each of the past four years,
    the distribution of American Indian/Alaska Native students and
    faculty (number and percentage) for the whole partner institution
    and for each NARCH Program participating school and/or department.

3.  Provide brief evidence of the academic institution's commitment to
    the hiring of American Indian/Alaska Native faculty (including those
    in science departments) and to the training of American
    Indian/Alaska Native students. Briefly describe and summarize any
    significant achievements within the last three years of any
    specialized programs at the institution that have encouraged and
    have helped to recruit/retain American Indian/Alaska Native students
    and faculty in the NARCH Program participating departments.

4.  Provide a brief summary, by year and American Indian/Alaska Native
    group, of the degrees awarded by each proposed NARCH participating
    department for the last four years. Use a separate table for
    undergraduate and graduate students.

5.  For competing renewal applications, document the number, type
    (undergrad, grad, postdoc) and outcome (PhD, MPH, BS, certificate,
    etc.) of each trainee and or faculty development beneficiary and
    list each publication and/or successful grant application resulting
    from the previous NARCH award. These may be organized in tabular
    format.

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B.  **[Proposed NARCH Program Plan and Its Anticipated Value to the
    Partnership]{.underline}**

> (Do not exceed four pages, not including tables and graphs.)

Provide a concise description of goals and objectives of the overall
NARCH program. Clearly state how the proposed NARCH Program will
enhance/assist the partnership's efforts to provide expanded
opportunities for American Indians/Alaska Natives in biomedical and
health services research, and to strengthen the institutional research
and research training capability. Describe specific measurable
improvements, anticipated as a consequence of the NARCH grant, in
faculty accomplishments (e.g. publications, grant applications, grant
funds, etc.). Provide a brief overview of the research interests, stage
in research career (beginning, established, retooling, etc.) and
potential for growth (improvement) of the faculty members applying for
research support as well as availability of senior faculty willing and
able to serve as mentors. Describe the probable research career goals
(e.g. ability to successfully participate in open competition for
research grants) for the individual investigators beyond successful
completion of the proposed research project. Describe the plans and
activities to develop the partnership and the capacities of the
individual tribal and institutional partners, from the submission of the
application through the end of the proposed program. Sufficient
information should be provided so that a proper review can be conducted,
e.g., 1) specific objective(s), 2) rationale for and feasibility of the
proposed activity, 3) detailed description of the activity, including a
timetable if appropriate, and 4) resources available. For competing
renewal applications, report the center's accomplishments in these areas
and explain how the new award is expected to extend or build on those
accomplishments.

**SECTION 2 -- FORMAT FOR EACH PROJECT PROPOSED (WHETHER FOR STUDENT
DEVELOPMENT, FACULTY DEVELOPMENT, RESEARCH, OR PILOT RESEARCH)**

(Each Project should have all ten of the parts listed below, where
appropriate, collected together by project)

**I.** The following FACE PAGE format replaces a PHS 398 face page for
each individual project.

**[Investigator(s):]{.underline}** The Project Principal Investigators
should be listed first followed by collaborating investigators, if any,
which should be listed in alphabetical order.

> [**Type of Application**:]{.underline} Indicate whether the project is
> a student development project, faculty development project, regular
> research project, or pilot research project. Also indicate if this is
> a resubmission of an unfunded project previously submitted, a renewal
> of a previously funded NARCH project, or a new project.
>
> [**Protection Against Research Risks**:]{.underline} Provide the
> appropriate information for the proposed research project. See Form
> PHS 398 instructions for information required when human subjects or
> vertebrate animals are involved. Where hazardous conditions or
> substances are involved, details for training and protecting workers
> must be included in Part 4 of the Research Plan: Experimental Design
> and Methods, Form PHS 398.
>
> [**Costs**:]{.underline} Provide the appropriate cost information for
> the proposed project.
>
> *SAMPLE FACE PAGE FORMAT*
>
> NARCH INDIVIDUAL PROJECT

1\. Descriptive Title: (80 characters or less)

\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_

2\. Investigator(s)

Last Name First Name MI Degree Departments

\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_

\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_

\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_

3\. Type of Project:

Student Development Project \[ \] Faculty Development Project \[ \]

Regular Research Project \[ \] Pilot Research Project \[ \]

New \[ \] Renewal \[ \] Resubmission \[ \]

> 4\. Protection Against Research Risks:

A. Will Human Subjects be involved? Yes \[ \] No \[ \]

B. If yes, what is the status of IRB review? Completed \[ \]
Documentation Enclosed \[ \]

Pending \[ \]

5\. Vertebrate Animals

A. Will Vertebrate Animals be used? Yes \[ \] No \[ \]

B. If yes, list the species \_\_\_\_\_\_\_\_\_\_\_\_\_\_ and estimate
the number to be used\_\_\_\_\_\_\_.

If yes, what is the status of IACUC review? Completed \[ \]
Documentation Enclosed \[ \] Pending \[ \]

6\. Dates of Proposed Period of Support: from\_\_\_\_\_\_\_ through
\_\_\_\_\_\_\_\_

COSTS

7\. Costs Requested for Initial Budget Period

A. Direct Costs (\$)\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_ (for
grantee, including subcontractor F&A)

B. Total Costs (\$)\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_ ( item 7A +
grantee F&A for this project)

8\. Costs Requested for Proposed Period of Support

A. Direct Costs (\$)\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_

B. Total Costs (\$)\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_

**II**. **DESCRIPTION, PERFORMANCE SITES AND PERSONNEL** (Use Form PHS
398 Form Page 2)

**III**. **TABLE OF CONTENTS** (Use Form PHS 398 Form Page 3, Table of
Contents.) Keep page numbers consistent with the total NARCH proposal
(ie, DON'T start over from page 1 for each project. All pages in the
entire application should be numbered consecutively).

**IV.** **BUDGETS** (Use Form PHS 398 Form Pages 4 and 5)

Prior to preparation of budgets for each project, please carefully
review the Form PHS 398 instructions and also additional instructions
included herein. Allowable costs are outlined in the NARCH Request for
Applications. Pay careful attention to the instructions for budget
justification on pages 24-29 in the PHS 398 Instructions. Justification
of budget items should be presented on Page 5 of Form PHS 398 and any
continuation page(s) required. Individual budget items of the same type,
from all of the projects, should be combined in preparing the Overall
Summary Budget for the NARCH.

**[Personnel:]{.underline}** Grantee personnel only. Subcontractor
personnel should be listed in the subcontractor budget form page 4,
attached and following form page 5 of the grantee. Any grantee personnel
costs necessary for monitoring of the subcontract(s) should be included
in the project budget. An explanation of the fringe benefits and rates
should be given. The cited rate should be applicable for all employees
based on their classification as full time, part-time, or temporary
status. In preparing the Overall Summary Budget for the NARCH (and only
in the Overall Summary Budget), personnel costs may be combined and
listed by project, as long as each person/position is listed
individually on form page 4 of each project they participate in.
Personnel may participate in more than one project, in which case they
should be listed in both projects and their percent effort should be
divided and listed for each project. Personnel participation in more
than one portion of the NARCH should be described in each project, when
relevant to the goals of the NARCH. This would usually occur between a
research project and a training project. Likewise, the relationship
between the Tribe/Tribal organization and the investigator(s) and key
personnel should also be described in each project proposal, even if
this information is also in the biographical sketches.

**V.** **BIOGRAPHICAL SKETCH FOR EACH PROJECT INVESTIGATOR**

(Use Form PHS 398 Biographical Sketch Format page)

**VI. OTHER SUPPORT FOR PRINCIPAL INVESTIGATOR** (Use "Other Support"
format.

There is no \"form page\" for other support. Information on other
support should be provided in the *format* shown at
<http://grants.nih.gov/grants/funding/phs398/othersupport.pdf> ).

**VII. RESOURCES** (Use Form PHS 398, Resources Format Page)

**IIX**. **PUBLICATIONS** (Use Form PHS 398, Continuation Pages)

**IX.** **PROJECT PLAN** (Use Form PHS 398)

**Option A: If a Student Development Project is proposed:**

Provide detailed information on plans to provide opportunities for
students to become acquainted with and to participate in biomedical or
health services research, including interaction with American
Indian/Alaska Native role models.

Information required includes: 1) specific objective and goals, 2)
rationale for and feasibility of the approach chosen, 3) detailed
description of the activity, 4) plan for attracting desired student
pool, 5) resources available, including commitments and other
expressions of interest by off-campus scientists, laboratories and/or
other facilities, 6) description of faculty/student involvement, and 7)
evaluation plans and other follow-up activities. Include timetables.

Examples of supportable student developmental efforts are on-campus
research, seminars, workshops, and informal discussions by visiting
scientists, attendance at regional and national scientific meetings, and
participation in off-campus laboratory, clinical or health services
research and/or didactic research activities at other institutions
conducting high quality research. Other developmental activities may
also be supported.

Describe how students are to be selected to participate in developmental
activities, specifying the criteria to be used.

**Option** **B:** **If a Faculty Development Project is proposed:**

Provide detailed information on plans to provide opportunities for
selected faculty. For each activity include the name, faculty rank, and
tenure status, along with: 1) specific objective(s), 2) rationale for
and feasibility of the proposed activity, 3) detailed activity
description, including a timetable if appropriate, 4) resources
available for activities involving participation in an active research
group shall include letters of commitment and other expressions of
interest by the PI at the potential on-campus or off-campus facilities,
and 5) plans for establishing collaborative or other follow-up
activities.

**Option C: If a Regular Research Project is proposed**:

Follow Form PHS 398 instructions, including **[page
limitations]{.underline}**. The research project proposal should be
written so as to be able to stand on its own and to be reviewed and
budgeted independently from the rest of the NARCH. It should utilize all
the pages of the Form page 398, except the face page. The sequential
format should be:

> Introduction, Specific Aims, Background and Significance, Progress
> Report/Preliminary Studies, Research Design and Methods, Human
> Subjects, Vertebrate Animals, Consultants/Collaborators,
> Consortium/Contractual arrangements, Literature Cited.

**Option D: If a Pilot Project Research Project is proposed**:

Follow the instructions for a regular research project, including page
limitations. The sequential format should be:

Introduction, Specific Aims, Background and Significance, Progress
Report/Preliminary Studies, Research Design and Methods, Human Subjects,
Vertebrate Animals, Consultants/Collaborators, Consortium/Contractual
arrangements, Literature Cited.

**X.** **PROJECT CHECKLIST (**Use Form PHS 398 Checklist page)

**SECTION 3 CENTER CHECKLIST (**Use Form PHS 398 Checklist page)

**SECTION 4 APPENDICES (**List in TABLE OF CONTENTS by item)

**SUBMISSION OF THE APPLICATION**

As noted in the Request for Applications (RFA), each applicant must
submit a typed and signed original application, including the Checklist,
and one (1) single-sided photocopy of the entire application (including
Appendices and supporting documents) in one package to: **Division of
Grants Operations, Indian Health Service, Reyes Building, 801 Thompson
Avenue, TMP 360, Rockville, MD 20852-1627** (zip code is unchanged for
express/courier services), Telephone: (301) 443-5204.

Also, at the time of submission, send four (4) additional single-sided
photocopied and signed applications, including the Checklist,
Appendices, and supporting documentation to: **Center for Scientific
Review, National Institutes of Health, 6701 Rockledge Drive, Room 6160-
-MSC 7892, Bethesda, MD 20892-7720**, or Bethesda, MD 20817 (for express
or courier service). Telephone: (301) 435-0715. Please note that the NIH
Center for Scientific Review does not accept hand delivery.