Draft Agenda for Workshop:

"Advances Toward Measuring Diabetic Retinopathy and Neuropathy: from the
bench to the clinic and back again"

April 4-5, 2007, Baltimore, MD

**April 4, 2007**

**SESSION 1: Current gold standards** for characterizing retinopathy and
neuropathy in the clinic and in rodent models, with an overview of
putative disease mechanisms in each area

**Session Chair: Eva Feldman, M.D.**

**8:00-8:15 Opening Remarks Eva Feldman**

**8:15-9:15 Retinopathy Speakers:**

-   (8:15-8:45) Neil Bressler (clinical)  

    -   Retinal thickening by optical coherence tomography (diabetic
        macular edema)

    -   Nonmydriatic digital stereoscopic retinal imaging

-   (8:45-9:15) Tim Kern (animal) 

    -   animal models

    -   molecular, histologic, and immunohistochemical techniques and
        morphometric analysis

**9:15-10:15    Neuropathy Speakers **

-   (9:15-9:45) Vera Bril (clinical)

    -    Cooling detection thresholds. Pain assessment using an 11-point
        Likert visual analog scale of the modified short form McGill
        pain questionnaire. Monofilament testing and nerve conduction
        studies of the lower limbs. Quantitative measurement of
        vibration perception threshold. Nerve conduction studies^.^

-   (9:45-10:15) Nigel Calcutt (animal) 

    -   Animal models of neuropathy

    -   animal electrophysiology, nerve conduction and blood flow,
        arterial function

**10:15-10:30 Break**

**SESSION 2: New biomarkers and technologies being explored** for
clinical use or animal phenotyping

**Session Chair: Tim Kern**

1**0:30-12:30 Retinopathy Speakers (4):**

-   (10:30-11:00) Lloyd Aiello

> \- OCT, nonmydriatic digital stereoscopic retinal imaging & etc.

-   (11:00-11:30) Tony Adams / Marcus A. Bearse

    -   mfERG, FEOG, S-cone sensitivity

-   (11:30-12:00) Bruce Berkowitz

    -   oxygenation by MR, Mn-enhanced MRI, contrast-enhanced MRI

-   (12:00-12:30) Mara Lorenzi

    -   new biomarkers

**12:30--2:00 Lunch**

**SESSION 2: (New biomarkers and technologies being explored, cont'd)**

**2:00-4:00 Neuropathy Speakers (4):**

-   (2:00-2:30) Rayaz Malik

    -   clinical corneal confocal microscopy

-   (2:30-3:00) Michael Polydefkis

    -   clinical skin biopsies

-   (3:00-3:30) Paul Fernyhough  

    -   mitochondrial dysfunction---hot topic

-   (3:30-4:00) Doug Zochodne  

    -   NO, nerve regeneration, nerve fiber density

**4:00-4:15 Break**

**4:15-5:00 Investigators Round Table -- Session Chair: Nigel Calcutt**

**April 5, 2007**

**SESSION 3: Cutting edge technologies or biomarkers with potential**
for phenotyping neuropathy and retinopathy. 

**Session Chair: Bruce Berkowitz**

**8:30-9:30 Retinopathy:**

-   (8:30-9:00) TBD

    -   very high resolution OCT

-   (9:00-9:30) Kurt Denninghoff

    -   oxygenation by intravital spectroscopy

**9:30-10:30 Neuropathy:**

-   (9:30-10:00) Aristidis Veves

    -   -nerve axon reflex, skin microcirculation, medical hyperspectral
        imaging (MHSI) to investigate the hemoglobin saturation
        (S~HSI~O~2~; % of oxyhaemoglobin in total haemoglobin \[the sum
        of oxyhaemoglobin and deoxyhaemoglobin\]), ^31^P-MRI for ratio
        of inorganic phosphate to phosphocreatine (Pi/PCr).

-   (10:00-10:30) Karel Zuzak

    -   hyperspectral imaging---young, from intramural NIDDK

**10:30-10:45 Break**

**10:30-12:00 Imaging blood flow & cell physiology in situ :**

-   (10:30-11:00) Jonathan Linder

    -   ultrasound microvascular blood flow

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-   (11:00-11:30) Giorgio Terenghi

    -   Volumetric magnetic resonance imaging of dorsal root ganglia for
        the objective quantitative assessment of neuron death after
        peripheral nerve injury Experimental Neurology 203 (2007) 22--33

-   (11:30-12:00) Laura Dugan

    -   animal and human MRI for oxidative damage 

**12:00 Meeting Synopsis & Closing Remarks: Eva Feldman**