### Amendment #1 to RFP-NIH-NIAID-DAIT-08-10

**Statistical & Data Coordinating Center**

This amendment provides an update to the above-referenced RFP.

+-----------------------------------+-----------------------------------+
| **Amendment to Solicitation       | NIH-NIAID-DAIT-08-10              |
| No.:**                            |                                   |
+-----------------------------------+-----------------------------------+
| **Amendment No.:**                | 1 [(1^st^ posting)]{.mark}        |
+-----------------------------------+-----------------------------------+
| **Issue Date:**                   | August 8, 2007                    |
+-----------------------------------+-----------------------------------+
| **Effective Date:**               | August 8, 2007                    |
|                                   |                                   |
| **Proposal Due Date:**            | November 7, 2007, at 4:00 P.M.    |
|                                   | local time                        |
+-----------------------------------+-----------------------------------+
| **Issued By:**                    | Donald E. Collie                  |
|                                   |                                   |
|                                   | Contracting Officer               |
|                                   |                                   |
|                                   | NIH/NIAID\                        |
|                                   | Office of Acquisitions\           |
|                                   | 6700 B Rockledge Drive            |
|                                   |                                   |
|                                   | Room 3214, MSC 7612               |
|                                   |                                   |
|                                   | Bethesda, Maryland 20892-7612     |
+-----------------------------------+-----------------------------------+
| **Point of Contact:**             | Deborah Blyveis, Contract         |
|                                   | Specialist                        |
|                                   |                                   |
|                                   | blyveisd@niaid.nih.gov            |
+-----------------------------------+-----------------------------------+
| **Name and Address of Offeror:**  | To All Potential Offerors         |
+-----------------------------------+-----------------------------------+

The above numbered solicitation is amended as set forth below. The hour
and date specified for receipt of proposals **HAS NOT** been extended.
Offerors must acknowledge receipt of this amendment. Failure to receive
your acknowledgement of this amendment may result in the rejection of
your offer. This amendment shall be acknowledged in the following
manner:

-   By acknowledging receipt of this amendment on each copy of the offer
    submitted.

The RFP is amended as follows:

1.  On page 6, **ARTICLE B.4. ADVANCE UNDERSTANDING,** is updated to
    read as follows:

    a.  Specific elements of cost, which normally require prior written
        approval of the Contracting Officer before incurrence of the
        cost (e.g., foreign travel, consultant fees, subcontracts) will
        be included in this Article if the Contracting Officer has
        granted his/her approval prior to contract award.

> b\. The contractor agrees to accurately and factually represent the
> work conducted under this contract in all press releases. In
> accordance with NIH Manual Chapter 1754, misrepresenting contract
> results or releasing information that is injurious to the integrity of
> NIH may be construed as improper conduct. The complete text of NIH
> Manual Chapter 1754 can be found at:
> <http://www1.od.nih.gov/oma/manualchapters/management/1754/>. Press
> releases shall be considered to include the public release of
> information to any medium, excluding peer-reviewed scientific
> publications. The contractor shall ensure that the project officer has
> received an advance copy of any press release related to this contract
> not less than four (4) working days prior to the issuance of the press
> release.

2.  On page 6, under Article C.2.a.1, [Technical Progress
    Reports]{.underline}, \"Quarterly\" should be checked and
    \"Semi-Annually\" should not be checked.

3.  On page 36, **d.** **ESTIMATE OF EFFORT**, should read as follows:

> It is expected that a completion type contract will be awarded as a
> result of this RFP. To assist you in the preparation of your proposal,
> the Government considers the effort to be approximately 25.5 FTEs for
> the base period, zero additional FTEs for Option #1, 6 additional FTEs
> for Option #2, and 3 additional FTEs for Option #3. This information
> is furnished for the offeror\'s information only and is not to be
> considered restrictive for proposal purposes.

4.  On page 65, **EVALUATION OF OPTIONS**, 2) [Option 3 - Provision of
    SDCC Support Services for Additional DAIT Clinical Trial Programs
    and Projects]{.underline}, section (i) should read \"design and
    analyze additional Phase I-III clinical trials;\"

5.  On page 1 of **ATTACHMENT 2: STATEMENT OF WORK,** section **1)
    BACKGROUND and INTRODUCTION**, second paragraph, the last line
    should read \"Under the contract to be awarded in FY 2008, the ITN
    will participate in additional research activities, including
    non-clinical safety and efficacy evaluations and, on a limited
    basis, manufacture of investigational products.\"