[CURRICULUM VITAE]{.underline}

[Name]{.underline} Mrs.Banumathi Sankaran

[Address]{.underline} 1 Cyclotron Road, Lawrence berkeley Nat. lab.,

Berkeley, CA 94720, USA

[Tel:]{.underline} ++1 631 344 1055 (home)

++1 631 344 8210 (work)

[email:]{.underline} <skba4@hotmail.com>

[Citizenship:]{.underline} Indian

[Date of Birth:]{.underline} July 8, 1970

[Marital Status:]{.underline} Married

[Languages:]{.underline} Tamil (mother tongue), English (fluent), Hindi
(Good)

[Education History:]{.underline}

1990 B.Sc. in Physics, S.D.N.B.Vaishnav College for Women, Chennai,
India

1992 M.Sc. in Biophysics, Madras University, Chennai, India

1993 M.Phil. in Biophysics, Madras University, Chennai, India

1998 Ph.D. in Crystallography & Biophysics, Madras University, Chennai,
India

[Brief Chronology of Employment:]{.underline}

1995-1997 Senior Research Fellow, Madras University, Chennai, India

under Prof. Dr. D. Velmurugan

1998-1999 Research Associate, Madras University, Chennai, India

under Prof. Dr. D. Velmurugan

2000-2001 Postdoctoral Fellow, University of Hamburg, Institute of
Biomedical Biochemistry and Molecular Biology, Hamburg, Germany

under Prof. Dr. C. Betzel

2001-2004 Postdoctoral Fellow,

Brookhaven National Lab., NSLS,

Synchotron Radiation Research Section, NCI at Frederick, Frederick, MD

under Dr. Z. Dauter

[Awarded Fellowships:]{.underline}

Senior Research Fellowship, CSIR, Delhi, India

Research Associate Fellowship, CSIR, Delhi, India.

[Practical Crystallographic Knowledge:]{.underline}

Operating Systems: Working knowledge of Unix, Linux and Windows, Mac

Crystallographic software: Most of the common crystallographic softwares

Data collection: Synchrotron: EMBL-Hamburg beam lines, (DESY)

X9B Brookhaven Nation lab (NSLS)

Home Source: CAD4 (small molecules)

Rotating anode (Macromolecules)

[Crystallization]{.underline}

Limited experience in crystallization

[Research interest:]{.underline}

Experimental phasing, Radiation damage, Protein structure determination,
Assisting users at the synchrotron beamlines for data collection
(including processing and sometimes solving the structures also helping
for accessing and using the softwares).

[Current Research:]{.underline}

My current research focuses on the use of radiation damage in
experimental phasing, either by using the specific radiation damage to
locate the substructure and phase on the isomorphous difference only or
by combining the isomorphous signal with present anomalous signal to
enhance existing (S/M)AD phases.

[BIBLIOGRAPHY]{.underline}

1\. \"Stereoelectronic control of cope rearrangement energetics through
remote double-bonds in novel, rigid polycyclic frames\", Mehta G, Reddy
SHK, Pattabhi V, **Bhanumathi S**, Pramanik A and Chandrasekhar J.,
*J.Chem. Soc - perkin trans.* **1**, 1539-1541, (1993).

2\. \"Cycloaddition products of
tricyclo-\[6.2.1.0(2,7)\]undeca-2(7),4,9-triene-3,6-dione\",

Pattabhi V, **Banumathi S**, Mehta G and Padma S, *Acta Cryst*. **C50**,
594-597, (1994).

3\. \"Crystal-Structure of 8-(3,4-dimethylphenoxy)-16h
dinaphtho\[2,1-d-1\',2\'-g\] dioxaphosphocin

8-oxide\", Raj SSS, Velmurugan D, **Banumathi S**, Maninaidu S and
Sivakumar K,

*J.Chem.Cryst*. **24**, 67-70, (1994).

4\. \"Conformational interconversions in peptide beta-turns:
Discrimination between enantiomeric

conformations by chiral\", Raghothama S, Chaddha M, **Banumathi S**,
Ravikumar K,

Velmurugan D and Balaram P, *Biopolymers* **45**, 191-202, (1998).

5\. \"1 \',3 \'-diphenylspiro\[anthracene-9(10H),5 \'(4 \'
H)-pyrazol\]-10-one\", **Banumathi S**,

Velmurugan D, Raghunathan R and Sundaram MS, *Acta Cryst*. **C54**,
629-630, (1998).

6\.
\"9-(4-methoxyphenyl)-10-phenyl-3,4,6,7,9,10-hexahydro-1,8(2H,5H)-acridinedione\",

Ganesh VK, **Banumathi S**, Velmurugan D, Ramasubbu N and Ramakrishnan
VT, *Acta*

*Cryst*. **C54**, 633-635, (1998).

7\. \"Synthesis of Spiropyrazoline \[5.3\'\]4\'- Chromanones\",
Raghunathan R, Shanmugasundaram

M, **Bhanumathi S** and Malar EJP, *Heteroatom chem.* **9**, 327-332,
(1998).

8\. \"Methyl N-(tert-butoxycarbonyl)glycyl-L-valyl-L-tryptophanate\",
**Banumathi S**,

Velmurugan, D, Subramanian E, Katti SB and Haq W, *Acta Cryst*. **C54**,
1681 - 1683,

(1998).

9\. \"tert-Butoxycarbonyl-L-leucyl-L-threoninamide\", **Banumathi S**,
Velmurugan D,

Subramanian E, Ashish N and Kishore R, *Acta Cryst*. **C55**, 78-79,
(1999).

10\. \"Crystal and molecular structure of
9-methyl-3,4,6,7,910-hexahydro-2,2,8,8-tetramethyl 1,8-

(2H,5H)- acridinedione\", Ganesh VK, **Banumathi S**, Velmurugan D and
Ravikumar K,

*Cryst.Res.Tech*. **34**, 929-934, (1999).

11\. \"Methyl
1-(tert-butoxycarbonyl-L-alanyl-L-leucylamino)cyclooctane-1-carboxylate\",

**Banumathi S**, Velmurugan D, Ravikumar K, Vijayalakshmi S, Rao RB and
Balaram P,

*Acta Cryst*. **C55**, 1575-1577, (1999).

12\. \"Induced conformational preferences in a non-chiral beta-Ala
residue: X-ray diffraction, H-1

NMR, FT-IR and CD studies of Boc-beta-Ala-D-Ala-NHCH3 and
Boc-beta-Ala-L-Ala-

NHCH3\", Ashish, **Banumathi S**, Velmurugan D, Anushree and Kishore R,
*Tetrahedron*

**55**, 13791-13804, (1999).

13\. \"The crystal and molecular structure of
9-(3-pentyl)-3,4,6,7,9,10-hexahydro-1,8(2H,5H)-

acridine-dione\", Sankaranarayanan S, **Banumathi S**, Velmurugan D,
Rafi ZA and

Ramasubbu N, *Cryst.Res.Tech*. **34**, 1345-1345, (1999).

14\. \"The crystal and molecular structure of tert-butoxycarbonyl
-alpha-aminoisobutyryl-

isoleucyl-methylester\", Nilofarnissa M, **Banumathi S**, Velmurugan D
and Ramasubbu N,

*Cryst.Res.Tech*. **35**, 333-341, (2000).

##### 15. \"Context-dependent conformation of diethylglycine residues in peptides\", Kaul R, 

#####  **Banumathi S**, Velmurugan D, Ravikumar K, Rao RB and Balaram P, *J.Pep.Res.* **55**, 271- 

#####  278, (2000). 

16\. \"Conformational choice at alpha,alpha-di-n-propylglycine residues:
Helical or fully

extended structures?\", Kaul R, **Banumathi S**, Velmurugan D, Rao RB
and Balaram P,

*Biopolymers* **54**, 159-167, (2000).

17 . \"2,2 \'-Methylenebis(3-hydroxy-2-cyclohexen-1-one)\", SethuSankar
K, **Banumathi S**,

Krishna R and Velmurugan D, *Acta Cryst*. **C56**, 479-480, (2000).

18\. \"Structure of the neurotoxic complex Vipoxin at 1.4 angstrom
resolution: A unique example

of evolution of the catalytic and toxic phospholipase A2 function into
inhibitory and

nontoxic ones\", Betzel C, **Banumathi S**, Rajashankar K and Genov N,
*Biophys J.* **80**, 1691

(2001).

19\. \'\'Structural insight into oxybenzotriazole based coupling
reagents.

[Srivastava
TK](http://wos01.isiknowledge.com/CIW.cgi?SID=W6oBpp7G7bEoNAO3M59&Func=OneClickSearch&field=AU&val=Srivastava+TK&curr_doc=12/1&Form=FullRecordPage&doc=12/1),
[Haq
W](http://wos01.isiknowledge.com/CIW.cgi?SID=W6oBpp7G7bEoNAO3M59&Func=OneClickSearch&field=AU&val=Haq+W&curr_doc=12/1&Form=FullRecordPage&doc=12/1),
[**Bhanumati
S**](http://wos01.isiknowledge.com/CIW.cgi?SID=W6oBpp7G7bEoNAO3M59&Func=OneClickSearch&field=AU&val=Bhanumati+S&curr_doc=12/1&Form=FullRecordPage&doc=12/1),
[Velmurugan
D](http://wos01.isiknowledge.com/CIW.cgi?SID=W6oBpp7G7bEoNAO3M59&Func=OneClickSearch&field=AU&val=Velmurugan+D&curr_doc=12/1&Form=FullRecordPage&doc=12/1),
[Sharma
U](http://wos01.isiknowledge.com/CIW.cgi?SID=W6oBpp7G7bEoNAO3M59&Func=OneClickSearch&field=AU&val=Sharma+U&curr_doc=12/1&Form=FullRecordPage&doc=12/1),
[Jagannathan
NR](http://wos01.isiknowledge.com/CIW.cgi?SID=W6oBpp7G7bEoNAO3M59&Func=OneClickSearch&field=AU&val=Jagannathan+NR&curr_doc=12/1&Form=FullRecordPage&doc=12/1),
[Katti
SB](http://wos01.isiknowledge.com/CIW.cgi?SID=W6oBpp7G7bEoNAO3M59&Func=OneClickSearch&field=AU&val=Katti+SB&curr_doc=12/1&Form=FullRecordPage&doc=12/1)

Protein and peptide letters 8 (1): 39-44 FEB 2001

20\. \"The crystal and molecular structure of
tert-butoxycarbonyl-alpha-aminoisobutyryl-leucyl-

methyl ester\", Nissa MN, **Banumathi S**, Velmurugan D and Ramasubbu N,
*Cryst.Res.Tech.*

**36**, 499-507, (2001).

21\. \"3-(p-Chlorophenyl)-4-phenyl-4,5-di-hydroisoxazole-5-spiro-2 \'-1
\',2 \',3 \',4 \'-

tetrahydronaphthalen-1 \'-one\", Pandi AS, **Banumathi S**, Velmurugan
D, Raj SSS, Fun HK

and Manikandan S, *Acta Cryst*. **C57**, 819-820, (2001).

22\. \"Structure of the neurotoxic complex vipoxin at 1.4 angstrom
resolution\", **Banumathi S**,

Rajashankar KR, Notzel C, Aleksiev B, Singh TP, Genov N and Betzel C,
*Acta Cryst*. **D57**,

1552-1559, (2001).

23\. \"Structural studies on three plant diterpenoids from Leonotis
nepetaefolia\", Govindasamy L,

Rajakannan V, Velmurugan D, **Banumathi S** and Vasanth S,
*Cryst.Res.Tech*. **37**, 896-909,

(2002).

24\. \"Crystallization and structure analysis of Thermus flavus 5S rRNA
helix B\", Vallazza M,

**Banumathi S**, Perbandt M, Moore K, DeLucas L, Betzel C and Erdmann
VA, *Acta Cryst*.

**D58**, 1700-1703, (2002).

25\. \"Crystal structure of the jacalin-T-antigen complex and a
comparative study of lectin-T-

antigen complexes\", Jeyaprakash AA, Rani PG, Reddy GB, **Banumathi S**,
Betzel C, Sekar

K, Surolia A and Vijayan M, *J.M.B* **321**, 637-645, (2002).

26\. \"Cis-3-(p-Bromostyryl)-2-methyl-N-(phenyl-sulfonyl)indole\",
Thinagar S, Velmurugan D,

**Banumathi S**, Shanmuga S, Raj S, Fun HK and Kannadasan S, *Acta*
Cryst. **E58**, 1264-1266,

(2002).

27\. \"Phasing at high resolution using Ta6Br12 cluster\", **Banumathi
S**, Dauter M and Dauter Z,

*Acta Cryst*. **D59**, 492-498, (2003).

28\. \"Structure of the heterodimeric neurotoxic complex viperotoxin F
(RV-4/RV-7) from the

venom of Vipera russelli formosensis at 1.9 angstrom resolution\",
Perbandt M, Tsai IH,

Fuchs A, **Banumathi S**, Rajashankar KR, Georgieva D, Kalkura N, Singh
TP, Genov N and

Betzel C, *Acta Cryst*. **D59**, 1679-1687, (2003).

29\. \"Structural effects of radiation damage and its potential for
phasing\", **Banumathi S**, Zwart

PH, Ramagopal UA, Dauter M and Dauter Z, *Acta Cryst*. **D60,**
1085-1093, (2004).

30\. \"Radiation-damage induced phasing with anomalous scattering:
substructure solution and

phasing \", Zwart PH, **Banumathi S**, Dauter M and Dauter Z, *Acta
Cryst*. **D60,** 1958-1963,

(2004).

31\. \'\'Crystal structure of a carbohydrate induced homodimer of
phospholipase A(2) from

Bungarus caeruleus at 2.1 angstrom resolution

[Singh
G](http://wos01.isiknowledge.com/CIW.cgi?SID=W6oBpp7G7bEoNAO3M59&Func=OneClickSearch&field=AU&val=Singh+G&curr_doc=13/1&Form=FullRecordPage&doc=13/1),
[Gourinath
S](http://wos01.isiknowledge.com/CIW.cgi?SID=W6oBpp7G7bEoNAO3M59&Func=OneClickSearch&field=AU&val=Gourinath+S&curr_doc=13/1&Form=FullRecordPage&doc=13/1),
[Sarvanan
K](http://wos01.isiknowledge.com/CIW.cgi?SID=W6oBpp7G7bEoNAO3M59&Func=OneClickSearch&field=AU&val=Sarvanan+K&curr_doc=13/1&Form=FullRecordPage&doc=13/1),
[Sharma
S](http://wos01.isiknowledge.com/CIW.cgi?SID=W6oBpp7G7bEoNAO3M59&Func=OneClickSearch&field=AU&val=Sharma+S&curr_doc=13/1&Form=FullRecordPage&doc=13/1),
[**Bhanumathi
S**](http://wos01.isiknowledge.com/CIW.cgi?SID=W6oBpp7G7bEoNAO3M59&Func=OneClickSearch&field=AU&val=Bhanumathi+S&curr_doc=13/1&Form=FullRecordPage&doc=13/1),
[Betzel
C](http://wos01.isiknowledge.com/CIW.cgi?SID=W6oBpp7G7bEoNAO3M59&Func=OneClickSearch&field=AU&val=Betzel+C&curr_doc=13/1&Form=FullRecordPage&doc=13/1),
[Yadav
S](http://wos01.isiknowledge.com/CIW.cgi?SID=W6oBpp7G7bEoNAO3M59&Func=OneClickSearch&field=AU&val=Yadav+S&curr_doc=13/1&Form=FullRecordPage&doc=13/1),

[Srinivasan
A](http://wos01.isiknowledge.com/CIW.cgi?SID=W6oBpp7G7bEoNAO3M59&Func=OneClickSearch&field=AU&val=Srinivasan+A&curr_doc=13/1&Form=FullRecordPage&doc=13/1),
[Singh
TP](http://wos01.isiknowledge.com/CIW.cgi?SID=W6oBpp7G7bEoNAO3M59&Func=OneClickSearch&field=AU&val=Singh+TP&curr_doc=13/1&Form=FullRecordPage&doc=13/1)
Journal of structural biology 149 (3): 264-272 Mar 2005.

32. \'\'Structural insight into oxybenzotriazole based coupling
    reagents\'\' Sriva[stava
    TK](http://wos.isiknowledge.com/CIW.cgi?SID=B1b1ehIeBHGAjmCJjgb&Func=OneClickSearch&field=AU&val=Srivastava+TK&curr_doc=10/1&Form=FullRecordPage&doc=10/1),
    [Haq
    W](http://wos.isiknowledge.com/CIW.cgi?SID=B1b1ehIeBHGAjmCJjgb&Func=OneClickSearch&field=AU&val=Haq+W&curr_doc=10/1&Form=FullRecordPage&doc=10/1),

[**Bhanumati
S**](http://wos.isiknowledge.com/CIW.cgi?SID=B1b1ehIeBHGAjmCJjgb&Func=OneClickSearch&field=AU&val=Bhanumati+S&curr_doc=10/1&Form=FullRecordPage&doc=10/1),
[Velmurugan
D](http://wos.isiknowledge.com/CIW.cgi?SID=B1b1ehIeBHGAjmCJjgb&Func=OneClickSearch&field=AU&val=Velmurugan+D&curr_doc=10/1&Form=FullRecordPage&doc=10/1),
[Sharma
U](http://wos.isiknowledge.com/CIW.cgi?SID=B1b1ehIeBHGAjmCJjgb&Func=OneClickSearch&field=AU&val=Sharma+U&curr_doc=10/1&Form=FullRecordPage&doc=10/1),
[Jagannathan
NR](http://wos.isiknowledge.com/CIW.cgi?SID=B1b1ehIeBHGAjmCJjgb&Func=OneClickSearch&field=AU&val=Jagannathan+NR&curr_doc=10/1&Form=FullRecordPage&doc=10/1),
[Katti
SB](http://wos.isiknowledge.com/CIW.cgi?SID=B1b1ehIeBHGAjmCJjgb&Func=OneClickSearch&field=AU&val=Katti+SB&curr_doc=10/1&Form=FullRecordPage&doc=10/1)
Protein and peptide

letters 8 (1): 39-44 FEB 2001.

33. [\'\'Sequence-induced trimerization of phospholipase A(2): structure
    of a trimeric isoform of PLA(2) from common krait (Bungarus
    caeruleus) at 2.5 angstrom
    resolution\'\'](http://wos.isiknowledge.com/?SID=B1b1ehIeBHGAjmCJjgb&Func=Abstract&doc=14/1)

> [Singh
> G,](http://wos.isiknowledge.com/CIW.cgi?SID=B1b1ehIeBHGAjmCJjgb&Func=OneClickSearch&field=AU&val=Singh+G&curr_doc=14/1&Form=FullRecordPage&doc=14/1)
> [Gourinath
> S](http://wos.isiknowledge.com/CIW.cgi?SID=B1b1ehIeBHGAjmCJjgb&Func=OneClickSearch&field=AU&val=Gourinath+S&curr_doc=14/1&Form=FullRecordPage&doc=14/1),
> [Saravanan
> K](http://wos.isiknowledge.com/CIW.cgi?SID=B1b1ehIeBHGAjmCJjgb&Func=OneClickSearch&field=AU&val=Saravanan+K&curr_doc=14/1&Form=FullRecordPage&doc=14/1),
> [Sharma
> S](http://wos.isiknowledge.com/CIW.cgi?SID=B1b1ehIeBHGAjmCJjgb&Func=OneClickSearch&field=AU&val=Sharma+S&curr_doc=14/1&Form=FullRecordPage&doc=14/1),
> [**Bhanumathi
> S**](http://wos.isiknowledge.com/CIW.cgi?SID=B1b1ehIeBHGAjmCJjgb&Func=OneClickSearch&field=AU&val=Bhanumathi+S&curr_doc=14/1&Form=FullRecordPage&doc=14/1),
> [Betzel
> C](http://wos.isiknowledge.com/CIW.cgi?SID=B1b1ehIeBHGAjmCJjgb&Func=OneClickSearch&field=AU&val=Betzel+C&curr_doc=14/1&Form=FullRecordPage&doc=14/1),
> [Srinivasan
> A](http://wos.isiknowledge.com/CIW.cgi?SID=B1b1ehIeBHGAjmCJjgb&Func=OneClickSearch&field=AU&val=Srinivasan+A&curr_doc=14/1&Form=FullRecordPage&doc=14/1),
>
> [Singh
> TP.](http://wos.isiknowledge.com/CIW.cgi?SID=B1b1ehIeBHGAjmCJjgb&Func=OneClickSearch&field=AU&val=Singh+TP&curr_doc=14/1&Form=FullRecordPage&doc=14/1)
> Acta crystallographica section F-structural biology and
> crystallization communications 61: 8-13 Part 1 Jan 2005

# [MANUSCRIPTS SENT FOR PUBLICATION]{.underline}

34\. \"Ab initio structure determination of the triple mutant of bovine
pancreatic phospholipase A~2~

at atomic resolution using ACORN\", Rajakannan V, **Banumathi S**,
Velmurugan D, Dauter

Z, Dauter M, Tsai D and Sekar K, *Acta Cryst*. **D60** submitted (2005).

# [NON PEER-REVIEWED PUBLICATIONS]{.underline} 

35\. \"Structural effects of radiation damage and its potential for
phasing\", **Banumathi S**, Zwart, PH, Dauter, M, Dauter, Z, *National
Synchrotron Light Source Research Highlights, November 5, 2004*
(http://www.nsls.bnl.gov/newsroom/science/2004/11-Dauter.htm)

[REFERENCES]{.underline}

Prof. Dr. D. Velmurugan

Department of Biophysics and Crystallography,

University of Madras, Guindy Campus, Chennai --25.

Tel 0091-44-23621089

Email <d_velu@yahoo.com>

Prof. Dr. C. Betzel

Institute for Biochemistry and Molecular Biology,

University of Hamburg, c/o DESY,

Notkestrasse 85,22603, Hamburg, Germany.

Tel 0049-40-89984744

email <betzel@unisgi1.desy.de>

Dr. Z. Dauter

Brookhaven National Lab.,

NSLS, Upton, NY --11973.

Tel 001-631-344-2519

email [dauter@anl.gov](mailto:dauter@bnl.gov)