**SERUM PANELS USED FOR STUDIES**

#  SERUM SUPPLIED BY VACCINE COMPONENTS

**1. ALAN HAMPSON ADULTS A/NEW CALEDONIA/20/99 (H1N1)**

**WHO, MELBOURNE ELDERLY A/PANAMA/2007/99 (H3N2)**

**AUSTRALIA B/JOHANNESBURG/5/99**

**2. JOHN WOOD, PH.D. ADULTS A/NEW CALEDONIA/20/99 (H1N1)**

**NIBSC, LONDON ELDERLY A/PANAMA/2007/99 (H3N2)**

**ENGLAND B/GUANGDONG/120/2000**

**3. S. GRAVENSTEIN, M.D. ADULTS A/NEW CALEDONIA/20/99 (H1N1)**

**EASTERN VIRGINIA ELDERLY A/PANAMA/2007/99 (H3N2)**

**MEDICAL SCHOOL B/VICTROIA/504/2000**

**4. TAKATO ODIGARI, PH.D. ADULTS A/NEW CALEDONIA/20/99 (H1N1)**

**NIH, TOKYO ELDERLY A/PANAMA/2007/99 (H3N2)**

**JAPAN B/JOHANNESBURG/5/99**

ANTIGENS FOR SEROLOGIES

## H1N1

##### A/NEW CALEDONIA/20/99 \*

**A/HUBEI/288/2001**

**A/BANGKOK/255/2001**

**A/HAWAII/15/2001**

**A/WISCONSIN/12/2001**

**A/BRAZIL/821/2001**

**A/HONG KONG/747/2001**

**A/FUJIAN/156/2000**

**A/AUCKLAND/65/2001**

**A/CHRISTCHURCH/4/2001**

**\* = VACCINE STRAIN**

**HEMAGGLUTINATION INHIBITION ANTIBODY TITERS TO**

**INFLUENZA A (H1N1) VIRUSES**

+---------+------+----------------------+----+------+----+-----+-----+
| **      | **TE | **VIRUS STRAIN**     | *  |      | *  |     | **% |
| TRIAL** | ST** |                      | *G |      | *% |     | 4** |
|         |      |                      | MT |      | [\ |     |     |
|         | **SI |                      | ** |      | >] |     | **  |
|         | TE** |                      |    |      | {. |     | FOL |
|         |      |                      | *  |      | un |     | D** |
|         |      |                      | *P |      | de |     |     |
|         |      |                      | RE |      | rl |     | **  |
|         |      |                      | PO |      | in |     | RIS |
|         |      |                      | ST |      | e} |     | E** |
|         |      |                      | ** |      | 32 |     |     |
|         |      |                      |    |      | or |     |     |
|         |      |                      |    |      | 40 |     |     |
|         |      |                      |    |      | ** |     |     |
|         |      |                      |    |      |    |     |     |
|         |      |                      |    |      | *  |     |     |
|         |      |                      |    |      | *P |     |     |
|         |      |                      |    |      | RE |     |     |
|         |      |                      |    |      | PO |     |     |
|         |      |                      |    |      | ST |     |     |
|         |      |                      |    |      | ** |     |     |
+---------+------+----------------------+----+------+----+-----+-----+
| **USA** | **C  | **[A/N'CALEDONIA/    | ** | **   | ** | **8 | **4 |
|         | DC** | 20/99\*]{.underline} | 21 | 92** | 33 | 8** | 2** |
| **A     |      | A/BRAZIL/821/2001**  | ** |      | ** |     |     |
| DULTS** |      |                      |    | **1  |    | **9 | **4 |
|         |      | **A/HONG             | ** | 27** | ** | 6** | 2** |
| *       |      | KONG/747/2001**      | 29 |      | 54 |     |     |
| *N=24** |      |                      | ** | **1  | ** | **9 | **4 |
|         |      | **                   |    | 20** |    | 6** | 2** |
|         |      | A/AUCKLAND/65/2001** | ** |      | ** |     |     |
|         |      |                      | 31 | **   | 54 | **7 | **4 |
|         |      |                      | ** | 46** | ** | 1** | 2** |
|         |      |                      |    |      |    |     |     |
|         |      |                      | ** |      | ** |     |     |
|         |      |                      | 14 |      | 29 |     |     |
|         |      |                      | ** |      | ** |     |     |
+---------+------+----------------------+----+------+----+-----+-----+
|         |      | **\*IVR-116 STRAIN** |    |      |    |     |     |
+---------+------+----------------------+----+------+----+-----+-----+
|         | **CB | # A                  | ** | **   | ** | **7 | **4 |
|         | ER** | /N'CALEDONIA/20/99\* | 20 | 59** | 42 | 5** | 2** |
|         |      |                      | ** |      | ** |     |     |
|         |      | **A/HUBEI/288/2001** |    | **   |    | **7 | **5 |
|         |      |                      | ** | 78** | ** | 5** | 4** |
|         |      | **                   | 24 |      | 33 |     |     |
|         |      | A/BANGKOK/255/2001** | ** | **   | ** | **7 | **4 |
|         |      |                      |    | 48** |    | 1** | 2** |
|         |      | **A/HAWAII/15/2001** | ** |      | ** |     |     |
|         |      |                      | 20 | **   | 33 | **5 | **4 |
|         |      | **A                  | ** | 22** | ** | 8** | 2** |
|         |      | /WISCONSIN/12/2001** |    |      |    |     |     |
|         |      |                      | ** | **   | ** | **6 | **4 |
|         |      |                      | \< | 31** | 25 | 3** | 2** |
|         |      |                      | 10 |      | ** |     |     |
|         |      |                      | ** |      |    |     |     |
|         |      |                      |    |      | ** |     |     |
|         |      |                      | ** |      | 25 |     |     |
|         |      |                      | 11 |      | ** |     |     |
|         |      |                      | ** |      |    |     |     |
+---------+------+----------------------+----+------+----+-----+-----+
|         |      | **\*IVR-116 STRAIN** |    |      |    |     |     |
+---------+------+----------------------+----+------+----+-----+-----+

**HEMAGGLUTINATION INHIBITION ANTIBODY TITERS TO INFLUENZA**

**A (H1N1) VIRUSES**

+---------+-----+----------------------+----+----+----+------+------+
| **      | **  | **VIRUS STRAIN**     | *  |    | *  |      | **%  |
| TRIAL** | TES |                      | *G |    | *% |      | 4**  |
|         | T** |                      | MT |    | [\ |      |      |
|         |     |                      | ** |    | >] |      | **FO |
|         | **  |                      |    |    | {. |      | LD** |
|         | SIT |                      | *  |    | un |      |      |
|         | E** |                      | *P |    | de |      | **RI |
|         |     |                      | RE |    | rl |      | SE** |
|         |     |                      | PO |    | in |      |      |
|         |     |                      | ST |    | e} |      |      |
|         |     |                      | ** |    | 32 |      |      |
|         |     |                      |    |    | or |      |      |
|         |     |                      |    |    | 40 |      |      |
|         |     |                      |    |    | ** |      |      |
|         |     |                      |    |    |    |      |      |
|         |     |                      |    |    | *  |      |      |
|         |     |                      |    |    | *P |      |      |
|         |     |                      |    |    | RE |      |      |
|         |     |                      |    |    | PO |      |      |
|         |     |                      |    |    | ST |      |      |
|         |     |                      |    |    | ** |      |      |
+---------+-----+----------------------+----+----+----+------+------+
| **AUS** | *   | # A                  | *  | ** | *  | **   | **   |
|         | *CD | /N'CALEDONIA/20/99\* | *8 | 44 | *8 | 70** | 63** |
| **EL    | C** |                      | ** | ** | ** |      |      |
| DERLY** |     | **A/HUBEI/288/2001** |    |    |    | **   | **   |
|         |     |                      | *  | ** | *  | 65** | 71** |
| *       |     | **                   | *9 | 41 | *8 |      |      |
| *N=24** |     | A/BANGKOK/255/2001** | ** | ** | ** | **   | **   |
|         |     |                      |    |    |    | 43** | 63** |
|         |     | **A/                 | *  | ** | *  |      |      |
|         |     | WISCONSIN/12/2001**  | *7 | 26 | *4 | **   | **   |
|         |     |                      | ** | ** | ** | 61** | 71** |
|         |     | **A/HAWAII/15/2001** |    |    |    |      |      |
|         |     |                      | *  | ** | ** | **   | **   |
|         |     |                      | *9 | 40 | 13 | 48** | 50** |
|         |     |                      | ** | ** | ** |      |      |
|         |     |                      |    |    |    |      |      |
|         |     |                      | *  | ** | *  |      |      |
|         |     |                      | *7 | 23 | *4 |      |      |
|         |     |                      | ** | ** | ** |      |      |
+---------+-----+----------------------+----+----+----+------+------+
|         |     | **\* IVR-116         |    |    |    |      |      |
|         |     | STRAIN**             |    |    |    |      |      |
+---------+-----+----------------------+----+----+----+------+------+
|         | **  | # A                  | ** | ** | ** | **   | **   |
|         | CBE | /N'CALEDONIA/20/99\* | 10 | 52 | 21 | 75** | 72** |
|         | R** |                      | ** | ** | ** |      |      |
|         |     | **A/HUBEI/288/2001** |    |    |    | **   | **   |
|         |     |                      | ** | ** | ** | 83** | 76** |
|         |     | **                   | 12 | 65 | 29 |      |      |
|         |     | A/BANGKOK/255/2001** | ** | ** | ** | **   | **   |
|         |     |                      |    |    |    | 83** | 84** |
|         |     | **A/                 | ** | ** | ** |      |      |
|         |     | WISCONSIN/12/2001**  | \< | 53 | 17 | **   | **   |
|         |     |                      | 10 | ** | ** | 75** | 56** |
|         |     | **A/HAWAII/15/2001** | ** |    |    |      |      |
|         |     |                      |    | ** | ** | **   | **   |
|         |     |                      | ** | 53 | 38 | 67** | 63** |
|         |     |                      | 15 | ** | ** |      |      |
|         |     |                      | ** |    |    |      |      |
|         |     |                      |    | ** | *  |      |      |
|         |     |                      | ** | 36 | *8 |      |      |
|         |     |                      | 10 | ** | ** |      |      |
|         |     |                      | ** |    |    |      |      |
+---------+-----+----------------------+----+----+----+------+------+
|         |     | **\* IVR-116         |    |    |    |      |      |
|         |     | STRAIN**             |    |    |    |      |      |
+---------+-----+----------------------+----+----+----+------+------+

ANTIGENS FOR SEROLOGIES

## H3N2

**A/PANAMA/2007/99 \***

**A/ARGENTINA/3759/2001**

##### A/PHILIPPINES/78890/2001

**A/SINGAPORE/26/2001**

**A/SINGAPORE/15/2001**

**A/SOUTH AUSTRALIA/102/2001**

**A/CHILE/6416/2001**

**A/HONG KONG/762/2001**

**A/HAWAII/21/2001**

**A/ALASKA/14/2001**

**A/DARWIN/3/2000**

**A/FUJIAN/140/2000**

**\* = VACCINE STRAIN**

**HEMAGGLUTINATION INHIBITION ANTIBODY TITERS TO**

**INFLUENZA A (H3N2) VIRUSES**

+--------+-----+------------------------+----+----+----+-----+------+
| **T    | **  | **VIRUS STRAIN**       | *  |    | ** |     | **%  |
| RIAL** | TES |                        | *G |    | [\ |     | 4**  |
|        | T** |                        | MT |    | >] |     |      |
|        |     |                        | ** |    | {. |     | **FO |
|        | **  |                        |    |    | un |     | LD** |
|        | SIT |                        | *  |    | de |     |      |
|        | E** |                        | *P |    | rl |     | **RI |
|        |     |                        | RE |    | in |     | SE** |
|        |     |                        | PO |    | e} |     |      |
|        |     |                        | ST |    | 32 |     |      |
|        |     |                        | ** |    | or |     |      |
|        |     |                        |    |    | 40 |     |      |
|        |     |                        |    |    | ** |     |      |
|        |     |                        |    |    |    |     |      |
|        |     |                        |    |    | *  |     |      |
|        |     |                        |    |    | *P |     |      |
|        |     |                        |    |    | RE |     |      |
|        |     |                        |    |    | PO |     |      |
|        |     |                        |    |    | ST |     |      |
|        |     |                        |    |    | ** |     |      |
+--------+-----+------------------------+----+----+----+-----+------+
| **EU   | *   | # A/PANAMA/2007/99\*   | *  | *  | ** | *   | **1  |
| ROPE** | *CD |                        | *9 | *1 | 13 | *10 | 00** |
|        | C** | **AHONG                | ** | 65 | ** | 0** |      |
| **AD   |     | KONG/762/2001**        |    | ** |    |     | **   |
| ULTS** |     |                        | ** |    | ** | *   | 96** |
|        |     | **A/CHILE/6416/2001**  | 12 | *  | 13 | *10 |      |
| **     |     |                        | ** | *1 | ** | 0** | **   |
| N=24** |     | **A/HAWAII/21/2001**   |    | 20 |    |     | 96** |
|        |     |                        | *  | ** | *  | **7 |      |
|        |     | *                      | *7 |    | *4 | 9** | **   |
|        |     | *A/SINGAPORE/15/2001** | ** | ** | ** |     | 96** |
|        |     |                        |    | 58 |    | *   |      |
|        |     |                        | ** | ** | ** | *10 | **   |
|        |     |                        | 12 |    | 21 | 0** | 88** |
|        |     |                        | ** | *  | ** |     |      |
|        |     |                        |    | *2 |    | **7 |      |
|        |     |                        | *  | 61 | *  | 1** |      |
|        |     |                        | *6 | ** | *0 |     |      |
|        |     |                        | ** |    | ** |     |      |
|        |     |                        |    | ** |    |     |      |
|        |     |                        |    | 39 |    |     |      |
|        |     |                        |    | ** |    |     |      |
+--------+-----+------------------------+----+----+----+-----+------+
|        |     | **\* RESVIR 17         |    |    |    |     |      |
|        |     | STRAIN**               |    |    |    |     |      |
+--------+-----+------------------------+----+----+----+-----+------+
|        | **  | # A/PANAMA/2007/99\*   | ** | *  | *  | **8 | **   |
|        | CBE |                        | \< | *1 | *0 | 8** | 92** |
|        | R** | *                      | 10 | 01 | ** |     |      |
|        |     | *A/SINGAPORE/26/2001** | \< | ** |    | **8 | **   |
|        |     |                        | 10 |    | *  | 8** | 92** |
|        |     | **A/DARWIN/3/2000**    | ** | ** | *0 |     |      |
|        |     |                        |    | 62 | ** | **5 | **   |
|        |     | **A/FUJIAN/140/2000**  | ** | ** |    | 0** | 54** |
|        |     |                        | \< |    | *  |     |      |
|        |     | **A/CHILE/6416/2001**  | 10 | ** | *4 | **6 | **   |
|        |     |                        | ** | 22 | ** | 7** | 83** |
|        |     |                        |    | ** |    |     |      |
|        |     |                        | ** |    | *  | **6 | **   |
|        |     |                        | \< | ** | *4 | 3** | 79** |
|        |     |                        | 10 | 53 | ** |     |      |
|        |     |                        | \< | ** |    |     |      |
|        |     |                        | 10 |    | *  |     |      |
|        |     |                        | ** | ** | *0 |     |      |
|        |     |                        |    | 39 | ** |     |      |
|        |     |                        |    | ** |    |     |      |
+--------+-----+------------------------+----+----+----+-----+------+
|        |     | **\* RESVIR 17         |    |    |    |     |      |
|        |     | STRAIN**               |    |    |    |     |      |
+--------+-----+------------------------+----+----+----+-----+------+

**HEMAGGLUTINATION INHIBITION ANTIBODY TITERS TO**

**INFLUENZA A (H3N2) VIRUSES**

+--------+-----+----------------------+---+------+----+-----+------+
| **T    | **  | **VIRUS STRAIN**     | * |      | *  |     | **%  |
| RIAL** | TES |                      | * |      | *% |     | 4**  |
|        | T** |                      | G |      | [\ |     |      |
|        |     |                      | M |      | >] |     | **FO |
|        | **  |                      | T |      | {. |     | LD** |
|        | SIT |                      | * |      | un |     |      |
|        | E** |                      | * |      | de |     | **RI |
|        |     |                      |   |      | rl |     | SE** |
|        |     |                      | * |      | in |     |      |
|        |     |                      | * |      | e} |     |      |
|        |     |                      | P |      | 32 |     |      |
|        |     |                      | R |      | or |     |      |
|        |     |                      | E |      | 40 |     |      |
|        |     |                      | P |      | ** |     |      |
|        |     |                      | O |      |    |     |      |
|        |     |                      | S |      | *  |     |      |
|        |     |                      | T |      | *P |     |      |
|        |     |                      | * |      | RE |     |      |
|        |     |                      | * |      | PO |     |      |
|        |     |                      |   |      | ST |     |      |
|        |     |                      |   |      | ** |     |      |
+--------+-----+----------------------+---+------+----+-----+------+
| *      | *   | # A/PANAMA/2007/99\* | * | **   | ** | **4 | **   |
| *USA** | *CD |                      | * | 24** | 17 | 2** | 17** |
|        | C** | **A/S                | 1 |      | ** |     |      |
| **ELD  |     | AUSTRALIA/102/2001** | 2 | **   |    | **3 | **   |
| ERLY** |     |                      | * | 21** | ** | 3** | 13** |
|        |     | **A/PH               | * |      | 13 |     |      |
| **     |     | ILIPPINES/78890/01** |   | **   | ** | **6 | **   |
| N=24** |     |                      | * | 41** |    | 7** | 13** |
|        |     | **A/ALASKA/2001**    | * |      | ** |     |      |
|        |     |                      | 1 | **   | 33 | **9 | **   |
|        |     | **A/A                | 2 | 67** | ** | 2** | 25** |
|        |     | RGENTINA/3759/2001** | * |      |    |     |      |
|        |     |                      | * | **   | ** | **3 | **   |
|        |     |                      |   | 19** | 58 | 3** | 21** |
|        |     |                      | * |      | ** |     |      |
|        |     |                      | * |      |    |     |      |
|        |     |                      | 2 |      | ** |     |      |
|        |     |                      | 2 |      | 17 |     |      |
|        |     |                      | * |      | ** |     |      |
|        |     |                      | * |      |    |     |      |
|        |     |                      |   |      |    |     |      |
|        |     |                      | * |      |    |     |      |
|        |     |                      | * |      |    |     |      |
|        |     |                      | 3 |      |    |     |      |
|        |     |                      | 6 |      |    |     |      |
|        |     |                      | * |      |    |     |      |
|        |     |                      | * |      |    |     |      |
|        |     |                      |   |      |    |     |      |
|        |     |                      | * |      |    |     |      |
|        |     |                      | * |      |    |     |      |
|        |     |                      | 1 |      |    |     |      |
|        |     |                      | 0 |      |    |     |      |
|        |     |                      | * |      |    |     |      |
|        |     |                      | * |      |    |     |      |
+--------+-----+----------------------+---+------+----+-----+------+
|        |     | **\* RESVIR 17       |   |      |    |     |      |
|        |     | STRAIN**             |   |      |    |     |      |
+--------+-----+----------------------+---+------+----+-----+------+
|        | **  | #                    | * | **   | ** | **7 | **   |
|        | CBE |  A/PANAMA/2007/99\*  | * | 39** | 29 | 1** | 46** |
|        | R** |                      | 1 |      | ** |     |      |
|        |     | **A/PH               | 3 | **   |    | **4 | **   |
|        |     | ILIPPINES/78890/01** | * | 19** | ** | 3** | 33** |
|        |     |                      | * |      | 46 |     |      |
|        |     | **A                  |   | **   | ** | **8 | **   |
|        |     | /ARGENTINA/3759/01** | * | 68** |    | 8** | 58** |
|        |     |                      | * |      | ** |     |      |
|        |     |                      | 1 |      | 29 |     |      |
|        |     |                      | 3 |      | ** |     |      |
|        |     |                      | * |      |    |     |      |
|        |     |                      | * |      |    |     |      |
|        |     |                      |   |      |    |     |      |
|        |     |                      | * |      |    |     |      |
|        |     |                      | * |      |    |     |      |
|        |     |                      | 1 |      |    |     |      |
|        |     |                      | 4 |      |    |     |      |
|        |     |                      | * |      |    |     |      |
|        |     |                      | * |      |    |     |      |
+--------+-----+----------------------+---+------+----+-----+------+
|        |     | **\* RESVIR 17       |   |      |    |     |      |
|        |     | STRAIN**             |   |      |    |     |      |
+--------+-----+----------------------+---+------+----+-----+------+

ANTIGENS FOR SEROLOGIES

## B

**B/JOHANNESBURG/5/99 \* \*\***

### B/GUANGDONG/120/2000 \* \*\*

**B/VICTORIA/504/2000 \* \*\***

**B/SICHUAN/379/99 \*\***

#### B/SHIZUOKA/15/2001\*\*

**B/TEXAS/22/2001\*\***

**B/HONG KONG/692/2001 \*\***

**B/SICHUAN/317/2001 \*\***

**B/WUHAN/02/2001 \*\***

**B/SINGAPORE/1/2001 \*\***

##### B/BRAZIL/952/2001 \*\*

**B/SHIZUOKA/480/2000 \*\***

**B/BRAZIL/956/2000 \*\***

**B/JOHANNESBURG/69/2001 \*\***

**B/HAWAII/10/2001 \*\* !**

**B/HONG KONG/330/2001\*\* !**

**\* = VACCINE STRAIN**

**\*\* = ETHER TREATED**

**! = B/BEIJING/243/97-LIKE**

**HEMAGGLUTINATION INHIBITION ANTIBODY TITERS TO**

**INFLUENZA B VIRUSES**

+-------+------+---------------------+-----+------+-----+-----+-----+
| **TR  | **TE | **VIRUS STRAIN**    | *   |      | **% |     | **% |
| IAL** | ST** |                     | *GM |      | [\> |     | 4** |
|       |      |                     | T** |      | ]{. |     |     |
|       | **SI |                     |     |      | und |     | **  |
|       | TE** |                     | **  |      | erl |     | FOL |
|       |      |                     | PRE |      | ine |     | D** |
|       |      |                     | POS |      | }32 |     |     |
|       |      |                     | T** |      | or4 |     | **  |
|       |      |                     |     |      | 0** |     | RIS |
|       |      |                     |     |      |     |     | E** |
|       |      |                     |     |      | **  |     |     |
|       |      |                     |     |      | PRE |     |     |
|       |      |                     |     |      | POS |     |     |
|       |      |                     |     |      | T** |     |     |
+-------+------+---------------------+-----+------+-----+-----+-----+
| **    | **C  | #                   | **4 | **1  | **7 | **9 | **3 |
| USA** | DC** | B/VICTORIA/504/2000 | 4** | 43** | 1** | 2** | 8** |
|       |      |                     |     |      |     |     |     |
| **ADU |      | **B                 | **3 | **1  | **6 | **9 | **3 |
| LTS** |      | /SICHUAN/317/2001** | 6** | 10** | 3** | 2** | 8** |
|       |      |                     |     |      |     |     |     |
| **N   |      | **B/TEXAS/22/2001** | **3 | **1  | **5 | **8 | **3 |
| =24** |      |                     | 4** | 10** | 4** | 8** | 8** |
|       |      | **B/HONG            |     |      |     |     |     |
|       |      | KONG/692/01**       | **3 | **1  | **5 | **9 | **3 |
|       |      |                     | 2** | 04** | 0** | 2** | 8** |
|       |      | **                  |     |      |     |     |     |
|       |      | B/JO'BURG/69/2001** | **1 | **   | **2 | **7 | **3 |
|       |      |                     | 8** | 52** | 5** | 1** | 3** |
+-------+------+---------------------+-----+------+-----+-----+-----+
|       |      |                     |     |      |     |     |     |
+-------+------+---------------------+-----+------+-----+-----+-----+
|       | **CB | #                   | **6 | **1  | **6 | **8 | **4 |
|       | ER** | B/VICTORIA/504/2000 | 0** | 76** | 7** | 8** | 2** |
|       |      |                     |     |      |     |     |     |
|       |      | **B                 | **3 | **   | **5 | **7 | **4 |
|       |      | /SHIZUOKA/15/2001** | 2** | 99** | 4** | 9** | 2** |
|       |      |                     |     |      |     |     |     |
|       |      | **B/TEXAS/22/2001** | **3 | **   | **5 | **7 | **4 |
|       |      |                     | 2** | 93** | 4** | 9** | 6** |
|       |      | **B                 |     |      |     |     |     |
|       |      | /HONG/KONG/692/01** | **2 | **   | **5 | **7 | **4 |
|       |      |                     | 9** | 78** | 4** | 9** | 2** |
|       |      | **B                 |     |      |     |     |     |
|       |      | /SICHUAN/317/2001** | **2 | **   | **5 | **7 | **2 |
|       |      |                     | 3** | 58** | 0** | 9** | 9** |
|       |      | **B/HONG            |     |      |     |     |     |
|       |      | KONG/330/01**       | **1 | **   | **2 | **3 | **  |
|       |      |                     | 1** | 38** | 9** | 8** | 8** |
+-------+------+---------------------+-----+------+-----+-----+-----+
|       |      |                     |     |      |     |     |     |
+-------+------+---------------------+-----+------+-----+-----+-----+

**HEMAGGLUTINATION INHIBITION ANTIBODY TITERS TO**

**INFLUENZA B VIRUSES**

+---------+-----+---------------------+----+-----+------+----+------+
| **      | **  | **VIRUS STRAIN**    | ## |     | **%  |    | **%  |
| TRIAL** | TES |                     |  G |     | [\>] |    | 4**  |
|         | T** |                     | MT |     | {.un |    |      |
|         |     |                     |    |     | derl |    | **FO |
|         | **  |                     | *  |     | ine} |    | LD** |
|         | SIT |                     | *P |     | 32or |    |      |
|         | E** |                     | RE |     | 40** |    | **RI |
|         |     |                     | PO |     |      |    | SE** |
|         |     |                     | ST |     | *    |    |      |
|         |     |                     | ** |     | *PRE |    |      |
|         |     |                     |    |     | PO   |    |      |
|         |     |                     |    |     | ST** |    |      |
+---------+-----+---------------------+----+-----+------+----+------+
| **AUS** | *   | #                   | ** | **9 | **   | ** | **   |
|         | *AU | B/VICTORIA/504/2000 | 15 | 5** | 25** | 88 | 71** |
| **EL    | S** |                     | ** |     |      | ** |      |
| DERLY** |     | **                  |    | *   | **   |    | **   |
|         |     | B/BRAZIL/956/2001** | ** | *14 | 38** | ** | 63** |
| *       |     |                     | 24 | 3** |      | 92 |      |
| *N=24** |     | **B/WUHAN/02/2001** | ** |     | **   | ** | **   |
|         |     |                     |    | **6 | 21** |    | 67** |
|         |     | **B                 | ** | 7** |      | ** |      |
|         |     | /SHIZUOKA/15/2001** | 12 |     | **   | 79 | **   |
|         |     |                     | ** | *   | 29** | ** | 58** |
|         |     | **B/HONG            |    | *13 |      |    |      |
|         |     | KONG/330/01**       | ** | 8** | **   | ** | **   |
|         |     |                     | 23 |     | 17** | 92 | 42** |
|         |     | *                   | ** | **2 |      | ** |      |
|         |     | *B/HAWAII/10/2001** |    | 4** | **   |    | **   |
|         |     |                     | ** |     | 13** | ** | 38** |
|         |     |                     | 10 | **2 |      | 54 |      |
|         |     |                     | ** | 2** |      | ** |      |
|         |     |                     |    |     |      |    |      |
|         |     |                     | ** |     |      | ** |      |
|         |     |                     | 10 |     |      | 54 |      |
|         |     |                     | ** |     |      | ** |      |
+---------+-----+---------------------+----+-----+------+----+------+
|         |     |                     |    |     |      |    |      |
+---------+-----+---------------------+----+-----+------+----+------+
|         | **  | #                   | ** | *   | **   | ** | **   |
|         | CBE |  B/GUANGDONG/120/00 | 12 | *10 | 21** | 75 | 68** |
|         | R** |                     | ** | 0** |      | ** |      |
|         |     | **B                 |    |     | **   |    | **   |
|         |     | /SHIZUOKA/15/2001** | ** | *   | 21** | ** | 76** |
|         |     |                     | 10 | *11 |      | 79 |      |
|         |     | **B/TEXAS/22/2001** | ** | 6** | **   | ** | **   |
|         |     |                     |    |     | 21** |    | 71** |
|         |     | **B/HONG            | ** | **7 |      | ** |      |
|         |     | KONG/692/01**       | \< | 6** | **   | 79 | **   |
|         |     |                     | 10 |     | 13** | ** | 68** |
|         |     | **B                 | ** | **7 |      |    |      |
|         |     | /SICHUAN/317/2001** |    | 1** | **   | ** | **   |
|         |     |                     | ** |     | 17** | 71 | 64** |
|         |     | **B/HONG            | \< | **7 |      | ** |      |
|         |     | KONG/330/01**       | 10 | 1** | **   |    | *    |
|         |     |                     | ** |     | 17** | ** | *8** |
|         |     |                     |    | **  |      | 71 |      |
|         |     |                     | ** | \<1 |      | ** |      |
|         |     |                     | \< | 0** |      |    |      |
|         |     |                     | 10 |     |      | ** |      |
|         |     |                     | ** |     |      | 17 |      |
|         |     |                     |    |     |      | ** |      |
|         |     |                     | ** |     |      |    |      |
|         |     |                     | \< |     |      |    |      |
|         |     |                     | 10 |     |      |    |      |
|         |     |                     | ** |     |      |    |      |
+---------+-----+---------------------+----+-----+------+----+------+
|         |     |                     |    |     |      |    |      |
+---------+-----+---------------------+----+-----+------+----+------+

### A/NEW CALEDONIA/20/99 VACCINES

+---------------------+-----+------+-----+-----+---+------+------------+
| #                   | #   |      |     |     |   |      | **PER CENT |
|                     |  VI |      |     |     |   |      | R          |
| #                   | RUS |      |     |     |   |      | EDUCTION** |
|                     | ES  |      |     |     |   |      |            |
| # H1N1 VIRUSES      | WIT |      |     |     |   |      | **MEAN     |
|                     | H [ |      |     |     |   |      | (RANGE)**  |
|                     | \>] |      |     |     |   |      |            |
|                     | {.u |      |     |     |   |      |            |
|                     | nde |      |     |     |   |      |            |
|                     | rli |      |     |     |   |      |            |
|                     | ne} |      |     |     |   |      |            |
|                     |  50 |      |     |     |   |      |            |
|                     | % R |      |     |     |   |      |            |
|                     | EDU |      |     |     |   |      |            |
|                     | CTI |      |     |     |   |      |            |
|                     | ON  |      |     |     |   |      |            |
|                     | IN  |      |     |     |   |      |            |
|                     |     |      |     |     |   |      |            |
|                     | # P |      |     |     |   |      |            |
|                     | OST |      |     |     |   |      |            |
|                     | -VA |      |     |     |   |      |            |
|                     | CCI |      |     |     |   |      |            |
|                     | NE  |      |     |     |   |      |            |
|                     | GMT |      |     |     |   |      |            |
|                     |     |      |     |     |   |      |            |
|                     | #   |      |     |     |   |      |            |
|                     | NUM |      |     |     |   |      |            |
|                     | BER |      |     |     |   |      |            |
|                     |  LO |      |     |     |   |      |            |
|                     | W/N |      |     |     |   |      |            |
|                     | UMB |      |     |     |   |      |            |
|                     | ER  |      |     |     |   |      |            |
|                     | TES |      |     |     |   |      |            |
|                     | TED |      |     |     |   |      |            |
+---------------------+-----+------+-----+-----+---+------+------------+
|                     | ##  | ## C | #   | ##  | # | ## T |            |
|                     |     | BER  | # C |     | # | OTAL |            |
|                     |     |      | DC  |     |   |      |            |
+---------------------+-----+------+-----+-----+---+------+------------+
| *                   |     | **5  | *   |     |   | **7/ | **60       |
| *A/HAWAII/15/2001** |     | /6** | *2/ |     |   | 10** | (31-82)**  |
|                     |     |      | 4** |     |   |      |            |
+---------------------+-----+------+-----+-----+---+------+------------+
| **A/                |     | **1  | *   |     |   | **1/ | **22       |
| WISCONSIN/12/2001** |     | /6** | *0/ |     |   | 10** | (0-70)**   |
|                     |     |      | 4** |     |   |      |            |
+---------------------+-----+------+-----+-----+---+------+------------+
| *                   | ##  | **0  | *   |     |   | **0/ | **6        |
| *A/HUBEI/288/2001** |     | /6** | *0/ |     |   | 10** | (0-27)**   |
|                     |     |      | 4** |     |   |      |            |
+---------------------+-----+------+-----+-----+---+------+------------+
| **A                 |     | **0  | *   |     |   | **0/ | **30       |
| /BANGKOK/255/2001** |     | /6** | *0/ |     |   | 10** | (0-45)**   |
|                     |     |      | 4** |     |   |      |            |
+---------------------+-----+------+-----+-----+---+------+------------+
| **A                 |     | **1  | *   |     |   | **5  | **46       |
| /AUCKLAND/65/2001** |     | /3** | *4/ |     |   | /9** | (0-93)**   |
|                     |     |      | 6** |     |   |      |            |
+---------------------+-----+------+-----+-----+---+------+------------+
| **                  |     | **   | *   |     |   | **0  | **0 (0)**  |
| A/BRAZIL/821/2001** |     | ND** | *0/ |     |   | /6** |            |
|                     |     |      | 6** |     |   |      |            |
+---------------------+-----+------+-----+-----+---+------+------------+
| **A/CH              |     | **0  | **N |     |   | **0  | **6        |
| RISTCHURCH/4/2001** |     | /3** | D** |     |   | /3** | (0-17)**   |
+---------------------+-----+------+-----+-----+---+------+------------+
| ## ND= NO DATA      |     |      |     |     |   |      |            |
+---------------------+-----+------+-----+-----+---+------+------------+

### A/PANAMA/2007 VACCINES

+---------------------+-----+------+-----+-----+---+------+------------+
| #                   | #   |      |     |     |   |      | **PER CENT |
|                     |  VI |      |     |     |   |      | R          |
| #                   | RUS |      |     |     |   |      | EDUCTION** |
|                     | ES  |      |     |     |   |      |            |
| # H3N2 VIRUSES      | WIT |      |     |     |   |      | **MEAN     |
|                     | H [ |      |     |     |   |      | (RANGE)**  |
|                     | \>] |      |     |     |   |      |            |
|                     | {.u |      |     |     |   |      |            |
|                     | nde |      |     |     |   |      |            |
|                     | rli |      |     |     |   |      |            |
|                     | ne} |      |     |     |   |      |            |
|                     |  50 |      |     |     |   |      |            |
|                     | % R |      |     |     |   |      |            |
|                     | EDU |      |     |     |   |      |            |
|                     | CTI |      |     |     |   |      |            |
|                     | ON  |      |     |     |   |      |            |
|                     | IN  |      |     |     |   |      |            |
|                     |     |      |     |     |   |      |            |
|                     | # P |      |     |     |   |      |            |
|                     | OST |      |     |     |   |      |            |
|                     | -VA |      |     |     |   |      |            |
|                     | CCI |      |     |     |   |      |            |
|                     | NE  |      |     |     |   |      |            |
|                     | GMT |      |     |     |   |      |            |
|                     |     |      |     |     |   |      |            |
|                     | #   |      |     |     |   |      |            |
|                     | NUM |      |     |     |   |      |            |
|                     | BER |      |     |     |   |      |            |
|                     |  LO |      |     |     |   |      |            |
|                     | W/N |      |     |     |   |      |            |
|                     | UMB |      |     |     |   |      |            |
|                     | ER  |      |     |     |   |      |            |
|                     | TES |      |     |     |   |      |            |
|                     | TED |      |     |     |   |      |            |
+---------------------+-----+------+-----+-----+---+------+------------+
|                     | ##  | ## C | #   | ##  | # | ## T |            |
|                     |     | BER  | # C |     | # | OTAL |            |
|                     |     |      | DC  |     |   |      |            |
+---------------------+-----+------+-----+-----+---+------+------------+
| **                  |     | **4  | *   |     |   | **7/ | **48       |
| A/CHILE/6416/2001** |     | /4** | *3/ |     |   | 10** | (0-76)**   |
|                     |     |      | 6** |     |   |      |            |
+---------------------+-----+------+-----+-----+---+------+------------+
| **A/ARG             |     | **0  | *   |     |   | **0/ | **19       |
| ETNTINA/3759/2001** |     | /6** | *0/ |     |   | 14** | (0-38)**   |
|                     |     |      | 8** |     |   |      |            |
+---------------------+-----+------+-----+-----+---+------+------------+
| **A/PHILI           | ##  | **5  | *   |     |   | **5/ | **31       |
| PPINES/78890/2001** |     | /6** | *0/ |     |   | 12** | (0-76)**   |
|                     |     |      | 6** |     |   |      |            |
+---------------------+-----+------+-----+-----+---+------+------------+
| *                   |     | **   | *   |     |   | **0  | **0 (0)**  |
| *A/HAWAII/21/2001** |     | ND** | *0/ |     |   | /6** |            |
|                     |     |      | 6** |     |   |      |            |
+---------------------+-----+------+-----+-----+---+------+------------+
| **A/                |     | **   | *   |     |   | **6  | **71       |
| SINGAPORE/15/2001** |     | ND** | *6/ |     |   | /6** | (64-76)**  |
|                     |     |      | 6** |     |   |      |            |
+---------------------+-----+------+-----+-----+---+------+------------+
| **A/                |     | **0  | **N |     |   | **0  | **34       |
| SINGAPORE/26/2001** |     | /4** | D** |     |   | /4** | (22-41)**  |
+---------------------+-----+------+-----+-----+---+------+------------+
| **A/S               |     | **   | *   |     |   | **2  | **35       |
| A                   |     | ND** | *2/ |     |   | /8** | (17-59)**  |
| USTRALIA/102/2001** |     |      | 8** |     |   |      |            |
+---------------------+-----+------+-----+-----+---+------+------------+
| ## ND= NO DATA      |     |      |     |     |   |      |            |
+---------------------+-----+------+-----+-----+---+------+------------+

**B/SICHUAN/379/99-LIKE VACCINES**

+---------------------+-----+------+-----+-----+---+------+------------+
| #                   | #   |      |     |     |   |      | **PER CENT |
|                     |  VI |      |     |     |   |      | R          |
| #                   | RUS |      |     |     |   |      | EDUCTION** |
|                     | ES  |      |     |     |   |      |            |
| # B VIRUSES         | WIT |      |     |     |   |      |            |
|                     | H [ |      |     |     |   |      |            |
|                     | \>] |      |     |     |   |      |            |
|                     | {.u |      |     |     |   |      |            |
|                     | nde |      |     |     |   |      |            |
|                     | rli |      |     |     |   |      |            |
|                     | ne} |      |     |     |   |      |            |
|                     |  50 |      |     |     |   |      |            |
|                     | % R |      |     |     |   |      |            |
|                     | EDU |      |     |     |   |      |            |
|                     | CTI |      |     |     |   |      |            |
|                     | ON  |      |     |     |   |      |            |
|                     | IN  |      |     |     |   |      |            |
|                     |     |      |     |     |   |      |            |
|                     | # P |      |     |     |   |      |            |
|                     | OST |      |     |     |   |      |            |
|                     | -VA |      |     |     |   |      |            |
|                     | CCI |      |     |     |   |      |            |
|                     | NE  |      |     |     |   |      |            |
|                     | GMT |      |     |     |   |      |            |
|                     |     |      |     |     |   |      |            |
|                     | #   |      |     |     |   |      |            |
|                     | NUM |      |     |     |   |      |            |
|                     | BER |      |     |     |   |      |            |
|                     |  LO |      |     |     |   |      |            |
|                     | W/N |      |     |     |   |      |            |
|                     | UMB |      |     |     |   |      |            |
|                     | ER  |      |     |     |   |      |            |
|                     | TES |      |     |     |   |      |            |
|                     | TED |      |     |     |   |      |            |
+---------------------+-----+------+-----+-----+---+------+------------+
|                     | ##  | ##   | ##  | ##  | # | ## T | **MEAN     |
|                     |     | CBER | CDC |     | # | OTAL | (RANGE)**  |
|                     |     |      |     |     |   |      |            |
+---------------------+-----+------+-----+-----+---+------+------------+
| **B/TEXAS/22/2001** |     | **0  | *   |     |   | **1/ | **21       |
|                     |     | /6** | *1/ |     |   | 14** | (0-77)**   |
|                     |     |      | 8** |     |   |      |            |
+---------------------+-----+------+-----+-----+---+------+------------+
| **B/HONG            |     | **1  | *   |     |   | **1/ | **22       |
| KONG/692/2001**     |     | /6** | *0/ |     |   | 14** | (0-56)**   |
|                     |     |      | 8** |     |   |      |            |
+---------------------+-----+------+-----+-----+---+------+------------+
| **B                 |     | **0  | *   |     |   | **0/ | **8        |
| /SHIZUOKA/15/2001** |     | /6** | *0/ |     |   | 10** | (0-44)**   |
|                     |     |      | 4** |     |   |      |            |
+---------------------+-----+------+-----+-----+---+------+------------+
| **B                 |     | **1  | *   |     |   | **1/ | **25       |
| /SICHUAN/317/2001** |     | /6** | *0/ |     |   | 14** | (0-67)**   |
|                     |     |      | 8** |     |   |      |            |
+---------------------+-----+------+-----+-----+---+------+------------+
| *                   |     | **4  | *   |     |   | **8  | **62       |
| *B/HAWAII/10/2001** |     | /4** | *4/ |     |   | /8** | (50-94)**  |
|                     |     |      | 4** |     |   |      |            |
+---------------------+-----+------+-----+-----+---+------+------------+
| **B/HONG            |     | **6  | *   |     |   | *    | **74       |
| KONG/330/2001**     |     | /6** | *4/ |     |   | *10/ | (58-96)**  |
|                     |     |      | 4** |     |   | 10** |            |
+---------------------+-----+------+-----+-----+---+------+------------+
|                     |     |      |     |     |   |      |            |
+---------------------+-----+------+-----+-----+---+------+------------+
| **ND= NO DATA**     | *   |      |     |     |   |      |            |
|                     | *ET |      |     |     |   |      |            |
|                     | HER |      |     |     |   |      |            |
|                     | T   |      |     |     |   |      |            |
|                     | REA |      |     |     |   |      |            |
|                     | TED |      |     |     |   |      |            |
|                     | ANT |      |     |     |   |      |            |
|                     | IGE |      |     |     |   |      |            |
|                     | N** |      |     |     |   |      |            |
+---------------------+-----+------+-----+-----+---+------+------------+