+-------+------+------+--------+-----+-----+-----------+----------+
| **    |      |      |        |     |     |           |          |
| TABLE |      |      |        |     |     |           |          |
| 1:    |      |      |        |     |     |           |          |
| BASIC |      |      |        |     |     |           |          |
| STUDY |      |      |        |     |     |           |          |
| DES   |      |      |        |     |     |           |          |
| IGN** |      |      |        |     |     |           |          |
+-------+------+------+--------+-----+-----+-----------+----------+
| **D   | *    | **   | **Age  | **  |     | **DB TX   | **       |
| rug** | *Stu | Indi | R      | Num |     | D         | Protocol |
|       | dy** | cati | ange** | ber |     | uration** | Dose**   |
|       |      | on** |        | of  |     |           |          |
|       |      |      | **(ye  | P   |     | **        | **(m     |
|       |      |      | ars)** | ati |     | (weeks)** | g/day)** |
|       |      |      |        | ent |     |           |          |
|       |      |      |        | s** |     |           |          |
+-------+------+------+--------+-----+-----+-----------+----------+
|       |      |      |        | **  | **  |           |          |
|       |      |      |        | Dru | Pla |           |          |
|       |      |      |        | g** | ceb |           |          |
|       |      |      |        |     | o** |           |          |
+-------+------+------+--------+-----+-----+-----------+----------+
| **Pro | HCCJ | MDD  | 12 to  | 21  | 19  | 6         | 20 to 60 |
| zac** |      |      | 17     |     |     |           |          |
+-------+------+------+--------+-----+-----+-----------+----------+
|       | X065 | MDD  | 8 to   | 48  | 48  | 8         | 20       |
|       |      |      | 18     |     |     |           |          |
+-------+------+------+--------+-----+-----+-----------+----------+
|       | HCJE | MDD  | 8 to   | 109 | 110 | 9         | 20 or 10 |
|       |      |      | 17     |     |     |           |          |
+-------+------+------+--------+-----+-----+-----------+----------+
|       | HCJW | OCD  | 7 to   | 71  | 32  | 13        | 20 to 60 |
|       |      |      | 17     |     |     |           |          |
+-------+------+------+--------+-----+-----+-----------+----------+
| **Zol | 498  | OCD  | 6 to   | 92  | 95  | 12        | 25 to    |
| oft** |      |      | 17     |     |     |           | 200      |
+-------+------+------+--------+-----+-----+-----------+----------+
|       | 1001 | MDD  | 6 to   | 97  | 91  | 10        | 50 to    |
|       |      |      | 17     |     |     |           | 200      |
+-------+------+------+--------+-----+-----+-----------+----------+
|       | 1017 | MDD  | 6 to   | 92  | 93  | 10        | 50 to    |
|       |      |      | 17     |     |     |           | 200      |
+-------+------+------+--------+-----+-----+-----------+----------+
| **Pa  | 329  | MDD  | 12 to  | 93  | 88  | 8         | 20-40    |
| xil** |      |      | 18     |     |     |           | (imi     |
|       |      |      |        |     |     |           | 200-300) |
+-------+------+------+--------+-----+-----+-----------+----------+
|       | 377  | MDD  | 13 to  | 180 | 95  | 12        | 20 to 40 |
|       |      |      | 18     |     |     |           |          |
+-------+------+------+--------+-----+-----+-----------+----------+
|       | 676  | SAD  | 8 to   | 165 | 156 | 16        | 10 to 50 |
|       |      |      | 17     |     |     |           |          |
+-------+------+------+--------+-----+-----+-----------+----------+
|       | 701  | MDD  | 7 to   | 104 | 102 | 8         | 10 to 50 |
|       |      |      | 17     |     |     |           |          |
+-------+------+------+--------+-----+-----+-----------+----------+
|       | 704  | OCD  | 7 to   | 99  | 107 | 10        | 10 to 50 |
|       |      |      | 17     |     |     |           |          |
+-------+------+------+--------+-----+-----+-----------+----------+
| **Lu  | 1    | OCD  | 8 to   | 57  | 63  | 10        | 50 to    |
| vox** | 14.0 |      | 17     |     |     |           | 200      |
|       | 2.01 |      |        |     |     |           |          |
+-------+------+------+--------+-----+-----+-----------+----------+
| **Cel | C    | MDD  | 7 to   | 93  | 85  | 8         | 20 to 40 |
| exa** | IT-M |      | 17     |     |     |           |          |
|       | D-18 |      |        |     |     |           |          |
+-------+------+------+--------+-----+-----+-----------+----------+
|       | 9    | MDD  | 13 to  | 124 | 120 | 12        | 10 to 40 |
|       | 4404 |      | 18     |     |     |           |          |
+-------+------+------+--------+-----+-----+-----------+----------+
| **We  | 75   | ADD  | 6 to   | 72  | 37  | 4         | 150 to   |
| llbut |      |      | 12     |     |     |           | 250      |
| rin** |      |      |        |     |     |           |          |
+-------+------+------+--------+-----+-----+-----------+----------+
| **Ef  | 382  | MDD  | 7 to   | 80  | 85  | 8         | 37.5 to  |
| fexor |      |      | 17     |     |     |           | 225      |
| XR**  |      |      |        |     |     |           |          |
+-------+------+------+--------+-----+-----+-----------+----------+
|       | 394  | MDD  | 7 to   | 102 | 94  | 8         | 37.5 to  |
|       |      |      | 17     |     |     |           | 225      |
+-------+------+------+--------+-----+-----+-----------+----------+
|       | 396  | GAD  | 6 to   | 80  | 84  | 8         | 37.5 to  |
|       |      |      | 17     |     |     |           | 225      |
+-------+------+------+--------+-----+-----+-----------+----------+
|       | 397  | GAD  | 6 to   | 77  | 79  | 8         | 37.5 to  |
|       |      |      | 17     |     |     |           | 225      |
+-------+------+------+--------+-----+-----+-----------+----------+
| *     | CN10 | MDD  | 12 to  | 95  | 95  | 8         | 100 to   |
| *Serz | 4141 |      | 17     |     |     |           | 600      |
| one** |      |      |        |     |     |           |          |
+-------+------+------+--------+-----+-----+-----------+----------+
|       | CN10 | MDD  | 7 to   | 184 | 94  | 8         | 100 to   |
|       | 4187 |      | 17     |     |     |           | 600      |
+-------+------+------+--------+-----+-----+-----------+----------+
| *     | 45   | MDD  | 7 to   | 170 | 89  | 8         | 15 to 45 |
| *Reme |      |      | 17     |     |     |           |          |
| ron** |      |      |        |     |     |           |          |
+-------+------+------+--------+-----+-----+-----------+----------+

<table>
<colgroup>
<col style="width: 9%" />
<col style="width: 9%" />
<col style="width: 8%" />
<col style="width: 8%" />
<col style="width: 7%" />
<col style="width: 9%" />
<col style="width: 11%" />
<col style="width: 12%" />
<col style="width: 10%" />
<col style="width: 14%" />
</colgroup>
<tbody>
<tr class="odd">
<td colspan="10"><strong>TABLE 2: SCREENING AND KEY EXCLUSIONARY
CRITERIA</strong></td>
</tr>
<tr class="even">
<td><strong>Drug</strong></td>
<td><strong>Study</strong></td>
<td><strong>Indication</strong></td>
<td><p><strong>Extensive</strong></p>
<p><strong>DXScreen</strong></p></td>
<td><p><strong>Placebo</strong></p>
<p><strong>Lead-In</strong></p></td>
<td><p><strong>Exclude TX</strong></p>
<p><strong>Resistant</strong></p></td>
<td><p><strong>Excl. Current</strong></p>
<p><strong>Suicide Risk</strong></p></td>
<td><p><strong>Excl. H/O</strong></p>
<p><strong>Suicide Attempt</strong></p></td>
<td><p><strong>Excl. Bipolar</strong></p>
<p><strong>D/O</strong></p></td>
<td><p><strong>Excl. Family H/O</strong></p>
<p><strong>Bipolar Disorder</strong></p></td>
</tr>
<tr class="odd">
<td><strong>Prozac</strong></td>
<td>HCCJ</td>
<td>MDD</td>
<td>No</td>
<td>Yes</td>
<td>No</td>
<td>Yes</td>
<td>No</td>
<td>Yes</td>
<td>No</td>
</tr>
<tr class="even">
<td></td>
<td>X065</td>
<td>MDD</td>
<td>Yes</td>
<td>Yes</td>
<td>No</td>
<td>No</td>
<td>No</td>
<td>Yes</td>
<td>Yes</td>
</tr>
<tr class="odd">
<td></td>
<td>HCJE</td>
<td>MDD</td>
<td>Yes</td>
<td>Yes</td>
<td>Yes</td>
<td>Yes</td>
<td>No</td>
<td>Yes</td>
<td>Yes</td>
</tr>
<tr class="even">
<td></td>
<td>HCJW</td>
<td>OCD</td>
<td>No</td>
<td>No</td>
<td>No</td>
<td>Yes</td>
<td>No</td>
<td>Yes</td>
<td>Yes</td>
</tr>
<tr class="odd">
<td><strong>Zoloft</strong></td>
<td>498</td>
<td>OCD</td>
<td>No</td>
<td>Yes</td>
<td>No</td>
<td>No</td>
<td>No</td>
<td>Yes</td>
<td>No</td>
</tr>
<tr class="even">
<td></td>
<td>1001</td>
<td>MDD</td>
<td>No</td>
<td>No</td>
<td>No</td>
<td>Yes</td>
<td>Yes</td>
<td>Yes</td>
<td>No</td>
</tr>
<tr class="odd">
<td></td>
<td>1017</td>
<td>MDD</td>
<td>No</td>
<td>No</td>
<td>Yes</td>
<td>Yes</td>
<td>Yes</td>
<td>Yes</td>
<td>No</td>
</tr>
<tr class="even">
<td><strong>Paxil</strong></td>
<td>329</td>
<td>MDD</td>
<td>Yes</td>
<td>No</td>
<td>No</td>
<td>Yes</td>
<td>Yes (if OD)</td>
<td>Yes</td>
<td>No</td>
</tr>
<tr class="odd">
<td></td>
<td>377</td>
<td>MDD</td>
<td>No</td>
<td>Yes</td>
<td>No</td>
<td>Yes</td>
<td>No</td>
<td>Yes</td>
<td>No</td>
</tr>
<tr class="even">
<td></td>
<td>676</td>
<td>SAD</td>
<td>No</td>
<td>No</td>
<td>No</td>
<td>Yes</td>
<td>No</td>
<td>Yes</td>
<td>No</td>
</tr>
<tr class="odd">
<td></td>
<td>701</td>
<td>MDD</td>
<td>No</td>
<td>No</td>
<td>Yes</td>
<td>Yes</td>
<td>No</td>
<td>Yes</td>
<td>No</td>
</tr>
<tr class="even">
<td></td>
<td>704</td>
<td>OCD</td>
<td>No</td>
<td>No</td>
<td>Yes</td>
<td>Yes</td>
<td>No</td>
<td>Yes</td>
<td>No</td>
</tr>
<tr class="odd">
<td><strong>Luvox</strong></td>
<td>114.02.01</td>
<td>OCD</td>
<td>No</td>
<td>Yes</td>
<td>Yes</td>
<td>No</td>
<td>No</td>
<td>Yes</td>
<td>No</td>
</tr>
<tr class="even">
<td><strong>Celexa</strong></td>
<td>CIT-MD-18</td>
<td>MDD</td>
<td>No</td>
<td>Yes</td>
<td>Yes</td>
<td>Yes</td>
<td>Yes</td>
<td>Yes</td>
<td>No</td>
</tr>
<tr class="odd">
<td></td>
<td>94404</td>
<td>MDD</td>
<td>No</td>
<td>No</td>
<td>No</td>
<td>No</td>
<td>No</td>
<td>Yes</td>
<td>No</td>
</tr>
<tr class="even">
<td><strong>Wellbutrin</strong></td>
<td>75</td>
<td>ADD</td>
<td>No</td>
<td>Yes</td>
<td>No</td>
<td>No</td>
<td>No</td>
<td>No</td>
<td>No</td>
</tr>
<tr class="odd">
<td><strong>Effexor XR</strong></td>
<td>382</td>
<td>MDD</td>
<td>No</td>
<td>Yes</td>
<td>No</td>
<td>Yes</td>
<td>No</td>
<td>Yes</td>
<td>Yes</td>
</tr>
<tr class="even">
<td></td>
<td>394</td>
<td>MDD</td>
<td>No</td>
<td>Yes</td>
<td>No</td>
<td>Yes</td>
<td>No</td>
<td>Yes</td>
<td>Yes</td>
</tr>
<tr class="odd">
<td></td>
<td>396</td>
<td>GAD</td>
<td>No</td>
<td>Yes</td>
<td>No</td>
<td>Yes</td>
<td>No</td>
<td>Yes</td>
<td>Yes</td>
</tr>
<tr class="even">
<td></td>
<td>397</td>
<td>GAD</td>
<td>No</td>
<td>Yes</td>
<td>No</td>
<td>Yes</td>
<td>No</td>
<td>Yes</td>
<td>Yes</td>
</tr>
<tr class="odd">
<td><strong>Serzone</strong></td>
<td>CN104141</td>
<td>MDD</td>
<td>No</td>
<td>No</td>
<td>Yes</td>
<td>Yes</td>
<td>Yes</td>
<td>Yes</td>
<td>Yes</td>
</tr>
<tr class="even">
<td></td>
<td>CN104187</td>
<td>MDD</td>
<td>No</td>
<td>No</td>
<td>Yes</td>
<td>Yes</td>
<td>Yes</td>
<td>Yes</td>
<td>Yes</td>
</tr>
<tr class="odd">
<td><strong>Remeron</strong></td>
<td>45</td>
<td>MDD</td>
<td>No</td>
<td>No</td>
<td>Yes</td>
<td>Yes</td>
<td>Yes</td>
<td>Yes</td>
<td>Yes</td>
</tr>
</tbody>
</table>