**PUBLICATIONS 2002‑2006** (1/11/2006)

Nuclear Medicine Program Staff

Nuclear Science and Technology Division

Oak Ridge National Laboratory (*ORNL*)

**Peer-Reviewed Journal Articles**

Boll, R. A., Malkemus, D. and Mirzadeh, S. "Production of Actinium-225
for Alpha Particle-Mediated Radioimmunotherapy," *Appl. Radiat. Isot.*,
[62]{.underline}, 667-679 (2005).

Kennel, S. J., Lankford, P., Garland, M., Sundberg, J. P. and Mirzadeh,
S. "Biodistribution of Ra-225 Citrate in Mice: Retention of Daughter
Radioisotopes in Bone," *Nucl. Med. Biol.,* [32]{.underline}, 859-867
(2005).

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L. and Du, M. "Production of
Therapeutic Radioisotopes in the ORNL High Flux Isotope Reactor for
Applications in Nuclear Medicine, Oncology and Interventional
Cardiology," *J. Radioanalyt. Nucl. Chem.*, [263]{.underline} (2),
503-509 (2005).

Knapp, F. F., Jr., Turner, J. H., Jeong, J.-M. and Padhy, A. K. "Issues
Associated with the Use of the Tungsten-188/Rhenium-188 Generator and
Concentration System and Preparation of Re-188-HDD," *World Journal of
Nuclear Medicine*, [3]{.underline}, 137-143 (2004).

Reynen, K., Kockeritz, U., Kropp, J., Wunderlich, G., Knapp, F. F.,
Schmeisser, A, and Strasse, R. H. "Intracoronary Radiotherapy with a
Rhenium-188 Liquid-Filled PTCA Balloon System in In-Stent Restenosis:
Acute and Long-Term Angiographic Results, As Well As 1 Year Clinical
Follow-up," *Internat. J. Card.*, [95]{.underline}, 29-34 (2004).

Garland, M. A., Mirzadeh, S., Alexander, C. W., Hirtz, G. J., Hobbs, R.
W. and Knapp, F. F., Jr. "Flux Characterization of the Peripheral Target
Positions in the High Flux Isotope Reactor," *Appl. Radiat. Isot.,*
[59]{.underline}, 63-72 (2003).

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L. and Du, M. "Therapeutic
Radioisotope Production in the High Flux Isotope Reactor (HFIR)," *J.
Label Cmpds. Radiopharm*., [46]{.underline} (Suppl. 1), S320 (2003).

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L. and Garland, M.
"Production of Medical Radioisotopes in the ORNL High Flux Isotope
Reactor," *Transactions*, American Nuclear Society, [89]{.underline},
765-766 (2003).

Knapp, F. F., Jr. and Kropp, J. "The 11th Mediterranean Meeting on
Nuclear Medicine and Radiopharmaceuticals," *Eur. J. Nucl. Med*.,
[30]{.underline}, 1701-1702 (2003).

Haverlock, T. J., Mirzadeh, S. and Moyer, B. A. "Selectivity of
Calix\[4\]arene-bis(benzocrown-6) in the Complexation and Transport of
Francium Ion," *J. Amer. Chem. Soc.*, [125]{.underline}, 1126-1127
(2003).

Liepe, K., Kropp, J., Hliscs, R., Runge, R., Knapp, F. F., Jr. and
Franke, W.-G. "Radiation Dosimetry of Rhenium-188-HEDP in Human Prostate
Cancer Skeletal Metastases," *J. Nucl. Med.,* [44]{.underline}, 953-960
(2003).

Palmedo, H., Manka-Waluch, A., Albers, P., Schmidt, W., Guhlke, S.,
Reinhardt, M., Ezziddin, S., Joe, A., Roedel, R., Fimmers, H., Knapp, F.
F., Jr. and Biersack, H.-J. "Repeated Bone Targeted Therapy for
Hormone-Refractory Prostate Carcinoma: Randomized Phase II Trial with
the New, High-Energy Radiopharmaceutical Rhenium-188-HEDP," *J. Clin.
Oncol.,* [21]{.underline}, 2869-2875 (2003).

Ponsard, B., Hiltunen, J., Vera-Ruiz, H., Beets, A. L., Mirzadeh, S. and
Knapp, F. F., Jr. "The Tungsten-188/Rhenium-188 Generator: Effective
Coordination of Tungsten-188 Production Between the HFIR and BR2
Reactors," *J. Radioanalyt. Nucl. Chem.,* [257]{.underline}, 169-174
(2003).

Sloof, G. W., Knapp, F. F., Jr., van Lingen, A., Eersels, J.,
Poldermans, D. and Bax, J. J. "Nuclear Imaging Is More Sensitive For the
Detection of Viable Myocardium Than Dobutamine Echocardiography,"
*Nuclear Med. Commun.,* [24]{.underline}, 357-381 (2003).

Verberne, H. J., Sloof, G. W., Beets, A. L., Murphy, A. M., van
Eck-Smit, N. L. F. and Knapp, F. F., Jr. "Free Fatty Acid and Glucose
Uptake in a Transgenic Mouse Model of Stunned Myocardium," *Eur. J.
Nucl. Med.,* [30]{.underline}, 431-439 (2003).

Granadas, O. H., Stevens, S. L., Donnell, R. L., Costanza, M. J.,
Spencer R. H., Knapp, F. F., Jr., Shoieb, A. M., Brown, K. J., Reddick,
T. T., Freeman, M. B. and Goldman, M. H. "Effect of Intravascular
Radiation on the Distribution of Macrophages, Platelet-Derived Growth
Factor and Transforming Growth Factor in the Swine Iliac Artery,"
*Annals Vasc. Surg., in press.*

Knapp, F. F., Jr., "Radionuclide Generators: Their Continuing Important
Role to Provide Radioisotopes for Diagnosis and Therapy ," *J. Nucl.
Med., Invited Continuing Education Review, in preparation.*

Liepe, K., Hliscs, R., Kropp, J., Ningl, T. G., Runge, R., Koch, R.,
Knapp, F. F., Jr. and Franke, W.-G. "Rhenium-188-HEDP in the Palliative
Treatment of Bone Metastases," *Eur. J. Nucl. Med., submitted.*

Zetting, G., Dobrozemsky, G., Kirisits, C., Wexberg, P., Cejna, M.,
Mitterhauser, Knapp, F. F., Jr. and Dudczak, R. *"*Endovascular
Radiation with Liquid-Filled Balloons - The Impact of Reused Balloon
Catheters on the Projected Dose*," Appl. Radiat. Isot., submitted*

Buhman, K. K., Smith, S. J., Stone, S., Repa, J., Wong, J. S., Knapp, F.
F., Jr., Burri, B., Hamilton, R. L., Abumrad, N. A. and Farese, R. V.,
Jr. "DAGAT1 Is Not Essential for Intestinal Triacylglycerol Absorption
or Chylomicron Synthesis," *J. Biol. Chem.*, [277]{.underline},
25474-25479 (2002).

Febbraio, M., Guy, E., Coburn, C., Knapp, F. F., Jr., Beets, A. L.,
Abumrad, N. A. and Silverstein, R. L. "The Impact of Overexpression and
Deficiency of Fatty Acid Translocase (FAT)/CD36," *Mol. Cell. Biochem.*,
[239]{.underline}, 193-197 (2002).

Hambye, A.-S., Dobbelier, A., Vervaet, A. and Knapp, F. F., Jr. "Image
Quality of Rhenium-188 and Technetium-99*m* - Comparative Planar and
SPECT Evaluation in a Phantom Study - Implications for Dosimetric
Calculation," *World J. Nucl. Med. ,* [1]{.underline}, 12-20 (2002).

Kennel, S. J., Lankford, T., Daven, S., Foote, L., Taniguchi, K.,
Ohizumi, Y., Nakagawa, S., Mayumi, T. and Mirzadeh, S. "Therapy of Rat
Tracheal Carcinoma IC-12 in SCID Mice. Vascular Targeting with
^213^Bi-MAb TES-23," *Eur. J. Can*., 1278-1287 (2002).

Kennel, S. J., Brechbiel, M. W., Schlom, J. and Mirzadeh, S.
"Actinium-225 Conjugates of Mab CC49 and Humanized Delta CH2CC49," *Can.
Biother. and Radiopharm.*, [17]{.underline}, 219-231 (2002).

Kennel, S. J., Mirzadeh, S., Eckelman, W. C., Waldmann, T. A.,
Garmestani, K., Yordanov, A. T., Stabin, M. G. and Brechbiel, M. W.
"Vascular-Targeted Radioimmunotherapy with the Alpha-Particle Emitter,
Astatine-211," *Radiat. Res.*, [157]{.underline}, 633-641 (2002).

Mirzadeh, S., Lambrecht, F. Y. and Lambrecht, R. M. "Decay of
Tungsten-189," *Appl. Radit. Isot.,* [57]{.underline}, 637-646 (2002).

Sundram, F. X., Yu, S., Somanesan, S., Jeong, J. M., Bernal, P., Osorio,
M., Esguerra, R., Chau, T. C. M., Long, H. D., Hoa, N. V., Huy, N. D.
S., Onkhuudai, P., Lamjav, T., Zanzonico, P., Divgi, C., Padhy, A. K.,
Martindale, A., Saw, M. M., Rolland, Y. and Knapp, F. F., Jr. "Phase I
Study of Transarterial Rhenium-188 HDD Lipiodol in Treatment of
Inoperable Primary Hepatocellular Carcinoma - A Multicentre Evaluation,"
*World J. Nucl. Med.,* [1]{.underline}, 5-11 (2002).

**Book Chapters and Meeting Proceedings**

**and Special Publications Describing ORNL Technology**

Knapp, F. F., Jr., Mirzaeh, S., and Garland, M. "The Continuing
Important Role of High Flux Reactors for Production of Therapeutic
Medical Radioisotopes," *Invited Lecture, For, TECDOC, International
Symposium on Trends in Radiopharmaceuticals*, IAEA, Vienna, Austria, *in
press.*

Monroy-Guzman, F., Badillo Almaraz, V. E., Flores de la Torre, J. A.,
Cosgrove, J. M. and Knapp, F. F., Jr. "Hydroxyapatite-Based Mo-99/Tc-99m
and W-188/re-188 Generator Systems," *For, TECDOC, International
Symposium on Trends in Radiopharmaceuticals*, IAEA, Vienna, Austria, *in
press.*

Knapp, F. F., Jr., Cosgrove, J. M. and Porter, C. E. "The
Tungsten-188/Rhenium-188 Generator -- An Attractive Cost Effective
Source of Rhenium-188 for Clinical Use," Technical Document (TECDOC) \#
1065, *Research Coordination Meeting (RCM) on Radionuclide Generators,*
International Atomic Energy Agency (IAEA), Vienna, Austria, October 4-8,
2004*.*

Bax, J. J., Knapp, F. F., Jr. and Visser, F. C. "Single-Photon Imaging
of Myocardial Metabolism: Role of Iodine-123 Fatty Acids and Fluorine-18
Deoxyglucose," *In, Nuclear Medicine in Clinical Diagnosis and
Treatment*; P. J. Ell and S. S. Gambhir, Editors; 3^rd^ Edition,
Churchill Livingston, Edinburgh, 2004 (ISBN 0 443 07312 0).

Iyer, S. R. and Knapp, F. F., Jr. *Editors, for,* "Manual for Reactor
Production of Radioisotopes," International Atomic Energy Agency
(*IAEA*), TECDOC-1340; Vienna, Austria, January 2003.
(ISBN-92-0-101103-2).

Knapp, F. F., Jr. "Applications of Rhenium-188-Labeled Agents in
Oncology," *In, Proceedings*, the 11^th^ Mediterranean Symposium on
Nuclear Medicine and Radiopharmaceuticals, May 28-30, Athens, Greece;
Medittera Pub., Athens (ISBN 960-86437-2-4), pp. 147-156 (2003).

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L. and Du, M. "Production of
Therapeutic Radioisotopes in the ORNL High Flux Isotope Reactor," *In,
Proceedings*, International Isotope Society Meeting, Boston, MA, June
2-6, 2003.

Kropp, J., Pinkert, J., Wunderlich, G., and Knapp, F. F., Jr.,
"Radiohchemistry, Evaluation and First Clinical Results in the Treatment
of Oncologic Diseases with Rhenium-188-Labeled Microspheres," *In,
Proceedings*, the 11^th^ Mediterranean Symposium on Nuclear Medicine and
Radiopharmaceuticals, May 28-30, Athens, Greece; Medittera Pub., Athens
(ISBN 960-86437-2-4), pp. 157-166 (2003).

Mausner, L. F. and Mirzadeh, S. "Reactor Production of Radionuclides,"
*In*, Handbook of Radiopharmaceuticals: Radiochemistry and Applications,
M. J. Welch and C. Redvanly, *Editors*; John Wiley and Sons, Ltd., pp.
87-118 (2003).

Mirzadeh, S., Mausner, L. F. and Garland, M. "Reactor-Produced Medical
Radioisotopes," *In*, Handbook of Nuclear Chemistry, Volume 4, Chapter
3, pp. 1-46; A. Vertes, N. S. Klencsar, Editors; Kluwer Academic
Publishers, Amsterdam (2003).

Liepe, K., Kropp, J., Hliscs, R., Runge, R., Knapp, F. F., Jr. and
Kotzerke, J. "Rhenium-188 HEDP Dosimetry in Bone Pain Induced by
Prostate Cancer," *In, Proceedings*, the 11^th^ Mediterranean Symposium
on Nuclear Medicine and Radiopharmaceuticals, May 28-30, Athens, Greece;
Medittera Pub., Athens (ISBN 960-86437-2-4), pp. 69-82 (2003).

Ponsard, B., Mirzadeh, S. and Knapp, F. F., Jr. "Production of
Tungsten-188 in the BR2 Reactor in Collaboration with ORNL," *In,
Proceedings*, International Isotope Society Meeting, Boston, MA, June
2-6, 2003.

Roesch, F. and Knapp, F. F., Jr. "Radionuclide Generators," *In*,
Handbook of Nuclear Chemistry, Volume 4, Chapter 3, pp. 81-118; A.
Vertes, N. S. Klencsar, Editors; Kluwer Academic Publishers, Amsterdam
(2003).

Binney, S. E., Krane, K. S., Garland, M. A., Pertmer, G. A. and
Mirzadeh, S. "Measurement of Neutron Cross Sections for Medical
Isotopes," *Trans. Amer. Nucl. Soc.*, [86]{.underline}, 167-168 (2002).

Weinberger, J. and Knapp, F. F., Jr. "Use of Liquid-Filled Balloons for
Coronary Irradiation," *In, Vascular Brachytherapy*, R. Waksman,
*Editor, Third Edition*, Futura Publishing Co., Inc., Armonk, NY, pp.
753-790 (2002).

**Patents**

F. F. Knapp, S. Mirzadeh and R. Boll, "Reactor Production and
Purification of Promethium-147," *Disclosed*.

Mirzadeh, S., Du, M., Beets, A. L. and Knapp, F. F., Jr. "High Specific
Activity Platinum-195*m*,"

U. S. Patent No. 6,804,319, Issued October 12, 2004.

Beets, A. L., Du, M., Mirzadeh, S. and Knapp, F. F., Jr. "Method for
Preparation of High Specific Activity Reactor-Produced Lutetium-177,"
U.S. Patent No. 6,716,353, Issued April 5, 2004.

Mirzadeh, S., Du, M., Beets, A. L. and Knapp, F. F., Jr. "New Method for
Preparation of High Specific Activity Platinum-195*m* for Medical
Therapy," U. S. Patent No. 6,751,280, Issued June 15, 2004.

Knapp, Jr., F. F., Beets, A. L., Mirzadeh, S. and Guhlke, S.
"Concentration of Perrhenate and Pertechnetate Solutions," U.S. Patent
No. 5,729,821, Issued March 17, 1998.

Mirzadeh, S., Knapp, Jr., F. F. and Collins, E. D. \"A Tandem
Radioisotope Generator System for Preparation of Highly Concentrated
Solutions of Tc-99*m* from Low Specific Activity Mo-99," U.S. Patent No.
5,774,782, Issued June 30, 1998.

Mirzadeh, S. and Kennel, S. J. "Bismuth-213 Generator," *Disclosed.*

Knapp, Jr., F. F., Lisic, E. C., Mirzadeh, S. and Callahan, A. P.
\"Tungsten‑188/Carrier-Free Rhenium‑188 Perrhenic Acid Generator
System,\" U.S. Patent No. 5,275,802, Issued January 4, 1994.

Knapp, Jr., F. F. \"Radioiodinated Agent to Evaluate Gastrointestinal
Disease by Urine Analysis" The \"Wuerfel Test\", *Disclosed*.

Knapp, Jr., F. F., Lisic, E. C., Mirzadeh, S., and Callahan, A. P.
\"Tungsten‑188/Carrier-Free Rhenium‑188 Perrhenic Acid Generator
System,\" U.S. Patent No. 5,186,913, Issued February 17, 1993.

Srivastava, P. C. and Hasan, A. \"Enzyme-Targeted Diagnosis with
Radiohalogenated Nucleosides The Enzymometer,\" *Disclosed*.

Srivastava, P. C. and Hasan, A. \"Acyclonucleosides of 2-Nitroimidazole
and Uses as Diagnostic and Therapeutic Agents\", *Disclosed*.

Goodman, M. M., and Knapp, Jr., F. F. \"Aminopropyl Thiophene
Compounds,\" U.S. Patent 4,914,215, Patent Gazette, April 3, 1990.

Goodman, M. M. and Knapp, Jr., F. F. \"Radiohalogenated
Thienylamphetamine Derivatives for Evaluating Local Cerebral Blood
Flow,\" U.S. Patent 4,900,539, Patent Gazette, p. 925, February 13,
1990.

McPherson, D. W., Fowler, J. S., and Wolf, A. \"No Carrier Added
(^11^C)-Putrescine,\" U.S. Patent 4,874,600 (1990).

Goodman, M. M., and Knapp, Jr., F. F. \"Radioiodinated Branched
Carbohydrates,\" U.S. Patent 4,826,966, Patent Gazette, May 2, 1989.

Srivastava, P. C. \"Mercuric Acetate Phenyl Maleimide Useful for
Preparing Radiohalogenated Maleimides,\" U.S. Patent 4,812,577 (1989).

**Meeting Presentations, Invited Talks and Published Abstracts**

Knapp, F. F., Jr., *Invited Highlights Lecture*, European Nuclear
Medicine Congress *(EANM)*, Athens, Greece, Sept. 30-Oct. 4, 2006.

Knapp, F. F., Jr., *Chairman and Organizer, Symposium on Clinical
Evaluation of New Radiopharmaceuticals*, 9^th^ World Federation of
Nuclear Medicine and Biology *(WFNMB)* Congress, Seoul, Korea, Oct.
22-27, 2006.

Knapp, F. F., Jr., *Chairman, Symposium on Therapeutic Radionuclide
Generators, IAEA CRP Meeting,* April 3-7, 2006, Milan, Italy.

Knapp, F. F., Jr. "Reactor Production of Therapeutic Radioisotopes,"
*DOE Sister Laboratory Program*, Tajura Reactor, Tripoli, Libya,
February 19, 2006.

Knapp, F. F., Jr. "The ORNL High Flux Isotope Reactor -- Overview and
Current Research," *DOE Sister Laboratory Program*, Tajura Reactor,
Tripoli, Libya, February 19, 2006.

Knapp, F. F., Jr. "The Continuing Important Role of Research Reactors
for Production of Therapeutic Radioisotopes," *DOE Sister Laboratory
Program*, Tajura Reactor, Tripoli, Libya, February 19, 2006.

Knapp, F. F., Jr. "Therapeutic Applications of Rhenium-188 in Nuclear
Medicine and Oncology -- Current Status and Expected Future Perspectives
," *DOE Sister Laboratory Program*, Tajura Reactor, Tripoli, Libya,
February 19, 2006.

Knapp, F. F., Jr. "Molybdenum-99 -- Advantages of Direct Production
versus Fission Production," *DOE Sister Laboratory Program*, Tajura
Reactor, Tripoli, Libya, February 19, 2006.

Alonso, O., Chae, I.-H., Chung, J. K., Gutierrez, C., Kropp, J., Onsel,
C., Peix, A., Plonska, E., Szilvasi, I., Knapp, F. F., Padhy, A. K.,
Storto, G. and Dondi, M. "Intravascular Radiation Therapy with
liquid-Filled Rhenium-188 Balloon Catheter: results of an International
Atomic Energy Agency (IAEA) Multicentre Study," *World J. Nucl. Med*.,
[4]{.underline}, *Suppl. 1*, S-59 (2005).

Bernal, P., Chau, T., Erdenechimeg, S., Kumar, A., Srivastava, D.,
Pauswan, P., Ang, S., Barrenechea, E. A., Jeong, J. M., Onkhuudai, P.,
Knapp, F. F., Sundram, F. X., Divgi, C., Buscombe, J., Dondi, M. and
Padhy, A. K. "Rhenium-188 Lipiodol Therapy for Hepatocellular
Carcinoma," *World J. Nucl. Med*., [4]{.underline}, *Suppl. 1*, S-19
(2005).

Knapp, F. F., Jr. "The Continuing Important Role of High Flux Reactors
for Production of Therapeutic Medical Radioisotopes," *Invited Lecture,
For, International Symposium on Trends in Radiopharmaceuticals*, IAEA,
Vienna, Austria, November 14-18, 2005.

Knapp, F. F., Jr. "Therapeutic Applications of Rhenium-188 in Nuclear
Medicine and Oncology -- Current Status and Future Perspectives,"
*Invited Lecture, For,* *International Conference on Radiopharmaceutical
Therapy, World Radiopharmaceutical Therapy Council, WFNMB*, Limassol,
Cyprus, October 11-14, 2005; *World J. Nucl. Med*., [4]{.underline},
*Suppl. 1*, S-59 (2005).

Knapp, F. F., Jr., Mirzadeh, S., Stabin, M. and Brill, A. B. "Therapy
with High LET Radioisotopes -- Can Sufficient Levels of Attractive Auger
and Alpha Emitters be Produced to Make Their Use Practical ?," *Invited
Lecture, For,* *International Conference on Radiopharmaceutical Therapy,
World Radiopharmaceutical Therapy Council, WFNMB*, Limassol, Cyprus,
October 11-14, 2005; *World J. Nucl. Med*., [4]{.underline}, *Suppl. 1*,
S-60 (2005).

Knapp, F. F., Jr. "Therapeutic Applications of Rhenium-188 in Nuclear
Medicine and Oncology -- Current Status and Future Perspectives,"
*Symposium on Radioisotope Therapy*, Havana, Cuba, June 24-28, 2005
(*Unable to attend*).

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L., Du., M., Klein, J. A. and
Garland, M. "Direct Production of Lutetium-177 from Enriched Lu-176 in a
High Flux Reactor -- The Only Practical Route to Provide High Specific
Activity/Multi-Curie Levels of Lu-177 Required fro Routine Clinical
Use," *5th International Conference on Isotopes (5ICI)*, Brussels,
Belgium, April 24-29, 2005*.*

Knapp, F. F., Jr. "The Important Role of Research Reactors for
Production of Medical Radioisotopes," Department of Nuclear Medicine,
Seoul National University Hospital, Seoul, Korea, April 15, 2003.

Knapp, F. F., Jr. "The Production and Use of Therapeutic Radionuclides
for Nuclear Medicine and Oncology Applications," *Invited Plenary
Lecture,* *HANARO 2005 Conference -- The 10^th^ Anniversary*, Korea
Atomic Energy Research Institute *(KAERI)*, April 11-13, 2005.

Kropp, J., Reynen, K., Koeckeritz, U. And Knapp, F . F. "Intracoronary
Radiation Therapy: Placebo Controlled Study: A Report," *World J. Nucl.
Med*., [4]{.underline}, *Suppl. 1*, S-27 (2005).

Monroy-Guzman, F., Badillo Almaraz, V. E., Flores de la Torre, J. A.,
Cosgrove, J. M. and Knapp, F. F., Jr. "Hydroxyapatite-Based Mo-99/Tc-99m
and W-188/re-188 generator Systems," *For, International Symposium on
Trends in Radiopharmaceuticals*, IAEA, Vienna, Austria, November 14-18,
2005.

Chen, L., Wang, W. D., Chen, Y. C. and Knapp, F. F. "Generator Elution
and Concentration of Rhenium-188," 51^st^ Annual Meeting, Society of
Nuclear Medicine, *J. Nucl. Med*., [44]{.underline}, Abstract \# 1517
(2004).

Knapp, F. F., Jr. "Rhenium-188 and Lutetium-177-- Reactor Production and
Development and Applications of Therapeutic Radiopharmaceuticals,"
*Invited Lecture,* *6^th^ International Radiopharmaceutical Therapy
Colloquium*, Pre-Congress Meeting, *8^th^ Congress of the Asia and
Oceania Federation of Nuclear Medicine and Biology*, Beijing, China,
October 9, 2004.

Knapp, F. F., Jr. "Rhenium-188 -- A Generator-Derived Radioisotope with
Broad Therapeutic Applications in Nuclear Medicine and Oncology,"
*Invited Lecture,* *Research Coordination Meeting on Radionuclide
Generator Technologies for Therapeutic Radionuclides*, International
Atomic Energy Agency (IAEA), Vienna, Austria, October 4-7, 2004.

Knapp, F. F., Jr. "Rhenium-188 Agents for Liver Cancer Therapy --
Current Status and Future Perspectives," *Inaugural Clinical
Investigators Meeting for the Proposed European/Asia and Oceania Phase
I/II Study on Rhenium-188-DEDC Lipiodol Intrahepatic Arterial Therapy of
Hepatocellular Carcinoma*, Ferrara, Italy, September 9, 2004;
Pre-Congress Symposium of the Annual European Association of Nuclear
Medicine Congress, Helsinki, Finland, Sept. 4-8, 2004.

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L., Du, M. and Garland, M.
"Reactor Production of High Specific Activity Lutetium-177," *Eur. J.
Nucl. Med*., [31]{.underline}, Suppl. 2, S387 (2004) (Poster \# 455).

Knapp, F. F., Jr., "Rhenium-188 for Cancer Therapy -- A Reactor-Produced
Radioisotope with Broad Applications in Nuclear Medicine and Oncology,"
*NNSA/NA-243 Sister Laboratory Expert Mission*, Institute for Nuclear
Research (INR/ICN), Pitesti, Romania, September 13-15, 2004.

Knapp, F. F., Jr., "Reactor-Produced Therapeutic Radioisotopes,"
*NNSA/NA-243 Sister Laboratory Expert Mission*, Institute for Nuclear
Research (INR/ICN), Pitesti, Romania, September 13-15, 2004.

Knapp, F. F., Jr. "Molybdenum-99 -- Advantages for Direct Production
from Mo-98 Versus Fission Production," *NNSA/NA-243 Sister Laboratory
Expert Mission*, Institute for Nuclear Research (INR/ICN), Pitesti,
Romania, September 13-15, 2004.

Knapp, F. F., Jr., Mirzadeh, S., Beets, a. L., Du. M. and Garland, M.
"Reactor Production of High Specific Activity Lutetium-177," *Eur. J.
Nucl. Med.*, [31]{.underline} (Suppl. 2), S387 (2004).

Knapp, F. F., Jr. "New Developments with Unsealed Sources for Targeted
Radiotherapy," *Invited Lecture*, 51^st^ Bad Gastein Lecture, Bad
Gastein, Austria, January 14-17, 2004.

Kropp, J., Reynen, K., Koeckeritz, U., Wunderlich, G., Schmeisser, A.,
Knapp, F. F. and Strasser, R. R. "Intracoronary Radiotherapy with Re-188
Liquid-Filled Balloon: The Dresden Prospective, Randomized,
Placebo-Controlled, Double-Blind, In Stent Restenosis Trial (DRAIN),"
51^st^ Annual Meeting, Society of Nuclear Medicine, *J. Nucl. Med*.,
[44]{.underline}, Abstract \# 802 (2004).

Boll, R. A., Malkemus, D. W. and Mirzadeh, S. "Production of
Actinium-225 for Alpha Particle Mediated Radiotherapy," *For*, 225^th^
Annual Meeting, *Amer. Chem. Soc*., New Orleans, LA, March 23-27, 2003.

Boll, R. A., Malkemus, D. W. and Mirzadeh, S. "Production of
Actinium-225 for Alpha Particle Mediated Radiotherapy," *For,* Annual
ANS Meeting, San Diego CA, June 1-5, 2003*.*

Brown, K. K., Winegar, D. A., Franklin, M. C., Michaud, E. and Knapp, F.
F., Jr. "PPAR-Gamma Activation Restores Insulin Sensitivity and Improves
the Ability of the Diabetic Mouse Heart to Transport and Utilize Glucose
and Reduces Myocardial Triacylglycerol Accumulation," American heart
Association Meeting, Orlando, FL, November 9-12, 2003*.*

Craig, A. M., Marsh, D. J., Boll, R. A., Schweitzer, G. K. and Mirzadeh,
S. "Recoil-Separation of ^221^Fr from ^213^Bi from ^225^Ac," 225^th^
Annual Meeting, *Amer. Chem. Soc.*, New Orleans, LA, March 23-27, 2003.

Garland, M. A. and Mirzadeh, S. "Alternative Routes for Production of
^229^Th, ^225^Ra and ^225^Ac," 225^th^ Annual Meeting, *Amer. Chem.
Soc*., New Orleans, LA, March 23-27, 2003.

Garland, M. A. and Mirzadeh, S. "Reactor Production of Thorium-229,"
Annual ANS Meeting, San Diego CA, June 1-5, 2003*.*

Knapp, F. F., Jr. "Production of Medical Radioisotopes in the ORNL
HFIR - When is High Flux Needed ?" *Invited Lecture*, ANS Winter
Meeting, New Orleans, LA, November 16-20, 2003.

Knapp, F. F., Jr. "Targeted Radiotherapy with Rhenium-188 - An
Attractive Radioisotope for Broad Clinical Applications ," *Invited
Plenary Lecture*, European Nuclear Medicine Congress, Amsterdam, The
Netherlands, August 23-27, 2003.

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L. and Du, M. "Therapeutic
Radioisotope Production in the High Flux Isotope Reactor (HFIR)," 15th
International Radiopharmaceutical Symposium on Radiopharmaceutical
Chemistry," Sydney, Australia, August 10-14, 2003.

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L. and Du, M. "Production of
Therapeutic Radioisotopes in the ORNL High Flux Research Reactor
(HFIR)," *Invited Lecture*, Eighth International Symposium, The
Synthesis and Applications of Isotopes and Isotopically Labelled
Compounds, Isotope Society, Boston, MA, June 1-5, 2003.

Knapp, F. F., Jr. "Current Clinical Applications of Rhenium-188 from the
Tungsten-188/Rhenium-188 Generator," *Invited Lecture,* Mediterranean
Society for Nuclear Medicine and Radiopharmaceuticals, Athens, Greece,
May 28 - June 1, 2003.

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L. and Du, M. "Production of
Therapeutic Radioisotopes in the ORNL High Flux Research Reactor (HFIR)
for Applications in Nuclear Medicine, Oncology and Interventional
Cardiology," *Invited,* MARC VI Conference on Radioanalytical Chemistry,
Kona-Kailua, Hawaii, April 7-11, 2003.

Knapp, F. F., Jr. "New Developments with Unsealed Sources for Targeted
Radiotherapy," *Invited Lecture*, Annual Meeting, German Society of
Nuclear Medicine, Essen, Germany, April 3-6, 2003 (Prof. Dr. Dr. A.
Bockisch, Organizer).

Mirzadeh, S. "Actinium-225 Production at the Oak Ridge National
Laboratory," *Invited Lecture,* Alpha-Emitting Isotopes Workshop, Dubna,
Russia, April 26, 2003.

Mirzadeh, S., Du., M., Beets, A. L. and Knapp, F. F., Jr. "Reactor
Production of High Specific Activity Platinium-195m for Therapeutic
Applications," *Invited Lecture,* Annual Meeting, American Chemical
Society, New York, NY, September 7-11, 2003.

Knapp, F. F., Jr. and Biersack, H.-J., Co-Chairs, *Round Table
Discussion* on "Current Status and Future Clinical Applications of the
Tungsten-188/Rhenium-188 Generator," World Federation of Nuclear
Medicine and Biology *(WFNMB)* Meeting, Santiago, Chile, September 29,
2002.

Knapp, F. F., Jr. "Production of Therapeutic Radioisotopes in the High
Flux Isotope Reactor (HFIR)," *Invited Lecture,* COST D18 Meeting,
Heidelberg, Germany, July 22-25, 2002.

Knapp, F. F., Jr. "Rhenium-188 - Advantages and Clinical Potential for
Use of a Readily Available, Cost Effective Therapeutic Radioisotope for
Applications in Nuclear Medicine, Oncology and Interventional
Cardiology," *Invited Lecture*, 25 International Symposium on
Radioactive Isotopes in Clinical Medicine and Research, Bad Gastein,
Austria, January 8-11, 2002; *Eur. J. Nucl. Med.,* [29]{.underline}, S5
(2002).

Kropp, J., Reynen, K., Koeckeritz, U., Wunderlich, G., Schmeisser. A.,
Strasser, R. H. and Knapp, F. F., Jr. "Prevention of In-Stent Restenosis
with Liquid-Filled ^188^Re Balloon: The Dresden In-Stent Restenosis
Trial (DIRRT)," World Federation of Nuclear Medicine and Biology
Congress, Santiago, Chile, Sept. 30-Oct. 4, 2002; *World J. Nucl. Med.*,
[1]{.underline}, Suppl. 2, S13 (Abstract \# 22) (2002).

Kropp, J., Schmidt, S., Wunderlich, G., Schendtke, K. U., Breidert, M.,
McPherson, D. W. and Knapp, F. F., Jr. "A New and Simple test for
Exocrine Function of the Pancreas: Analysis of the Urine After Oral
Application of an I-131-Labeled Triglyceride," World Federation of
Nuclear Medicine and Biology Congress, Santiago, Chile, Sept. 30-Oct. 4,
2002; *World J. Nucl. Med.*, [1]{.underline}, Suppl. 2, S50 (Abstract \#
103) (2002).

Liepe, K., Hliscs, R., Knapp, F. F., Jr. and Kropp, J. "Dosimetry and
Therapeutic Effect of ^188^Re-HEDP in Human Prostate Cancer Skeletal
Metastases," Third North American Symposium on Skeletal Complications of
Malignancy, National Institutes of Health, Bethesda, MD, April 24-27,
2002.

WP70\\WPFILES\\PUBLIST - FFK: Jan. 11, 2006