*CURRICULUM VITAE*

**JAVED KHAN, M.D**

Principal Investigator,

Oncogenomics Section, Pediatric Oncology Branch

National Cancer Institute, National Institutes of Health

Room 134E, 8717 Grovemont Circle

Gaithersburg, MD, 20877

Phone Office: 301-435-2937

FAX: 301-480-0314

e-mail: <khanjav@mail.nih.gov>

**Home Address:** 17405 Millboro Terrace

Derwood, MD 20855

Tel: 301-527-1024

# **Marital Status:** Married with four children

# **Education:**

1972-1980 Mill Hill School, London, UK.

1981-1984 B.A. with Honors in Pathology, Immunology and Parasitology

> Queens' College, Cambridge University, UK.

1984-1986 M.B.B.Chir., (M.D.)

> Queens' College, Cambridge University, UK.

1989 M.A., Pathology, Immunology and Parasitology

> Queens' College, Cambridge University, UK.

1990 Membership of the Royal College of Physicians, (USA Pediatric
Boards equivalent), UK.

2005 General Pediatric Boards Certification USA.

May 2008 Achieved tenure at NIH

# 

# **Current Appointment:**

##### Date Place Position

2001-present Advanced Technology Center Senior Investigator

> & Pediatric Oncology Branch Attending Physician
>
> National Cancer Institute, NIH,
>
> Bethesda, MD

### 

### 

### 

### Previous Appointments:

1996-5/01 Cancer Genetics Branch Visiting Fellow

> NHGRI, NIH, Bethesda, MD

07/95-06/98 Pediatric Oncology Branch Fellow, Hematology

CCR, National Cancer Institute, Oncology

NIH, Bethesda, MD

1994-1995 The Sanger Center, Visiting Scientist

Welcome Trust Genome Campus,

> Hinxton, Cambridge, UK

08/93-05/95 Pediatric Oncology Department Clinical Lecturer, General
Pediatrics

Cambridge University, UK

02/91-07/93 Pediatric Oncology Department Fellow, Leukemia Research Fund

> Addenbrooke's Hospital,
>
> Cambridge, UK

07/90-01/91 The Hospitals for Sick Children Resident, Infectious
Diseases

> Great Ormond Street, London, UK Immunology, Dermatology
>
> & Neurosurgery

08/89-07/90 Queen\'s Medical Centre Resident, General Pediatrics

Nottingham, UK Neonatology, General Pediatrics,

Oncology & Endocrinology

02/88-07/89 Birmingham Children's Hospital Resident, Pediatric
Cardiology

> Sorrento Maternity Hospital Neonatology , Nephrology

Birmingham, UK & General Pediatrics

08/87-01/88 Addenbrooke's Hospital Intern, Internal Medicine

Cambridge, UK

02/87-07/87 Peterborough District Hospital Intern, General Surgery

> Peterborough , UK

# 

# 

# **Honors, Awards and Grants:**

1991. Entrance Exhibition Award, Queen's College, Cambridge University,
      UK

1994 Addenbrooke's Hospital Endowment Fund Research Grant, Cambridge, UK

1995 Allen & Hanbury Research Travel Award

1998 Merit Award, National Institutes of Health, Bethesda, MD, USA

1998 Outstanding Oral Presentation Award

National Human Genome Research Institute, National Institutes of Health,
Bethesda, MD, USA

2001. Scholar in Training Award, American Association of Cancer
      Research, USA

2001 National Cancer Institute, Intramural Research Award.

2002 Hope Street Kids, Pediatric Cancer Research Grant

2004 Children's Cancer Foundation, Pediatric Genome and Expression
Database

2005 Hope Street Kids, Pediatric Cancer Research Grant

2005 Office of Rare Diseases of the National Institutes of Health (NIH)
to organize an international meeting of Translational Genomics in
Neuroblastoma (TGiN) conference

2005 National Cancer Institute, Intramural Research Award for TGiN
Conference

2005. National Cancer Institute, Intramural Research Award

> Identification of prognostic signatures for high risk neuroblastoma
> using high resolution comparative genomic hybridization.

2006 Office of Rare Diseases of the National Institutes of Health (NIH)
to organize the second international meeting of Translational Genomics
in Neuroblastoma (TGiN) conference

2006 National Cancer Institute, Intramural Research Award for second
TGiN Conference

2006. National Cancer Institute, Director's Intramural Innovation Award

> Sensitive and Specific Detection of miRNA using Luminex Beads and
> Locked Nucleic Acid.

2007 Therapeutically Applicable Research to Generate Effective
Treatments (NBL-TARGET) Initiative to identify targets for
neuroblastoma. A collaboration between NCI, Children's Hospital of
Philadelphia, Children's Hospital Los Angeles and the Children's
Oncology Group

2007 NCI Award for development of NanoBioSensor for the detection of
nucleic acid hybridization using carbon nanotube and silicon nanowire
transistors. Collaboration between University of Maryland and NASA.

2007 Children's Cancer Foundation, Pediatric Genome and Expression
Database

# 

#  

# **Patents:**

2002 **Methods for analyzing high dimensional data for classifying,
diagnosing, prognosticating, and/or predicting diseases and other
biological states**

*United States Patent Application*

# 2002 **Selections of genes, methods of using the same for diagnosis of select cancers, and methods of targeting the therapy of select cancers.**

*United States Patent Application*

# 2004 **Selections of genes, methods of using the same for diagnosis and prediction of prognosis, in neuroblastoma..**

*United States Patent Application*

# 2006 **Apparatus for Microarray Binding Sensors Having Biological Probe materials Carbon Nanotube Transistors.**

*United States Patent Application*

######## 2008 Overexpression and mutation of a tyrosine kinase receptor FGFR4 in tumors.

######## U.S. Provisional Patent Application No. 61/044,875

######## Cooperative Research and Development Agreement (CRADA)

Title: Development of Polyvalent Liposomal Nanoparticles for Imaging and
Targeted Delivery of Drugs and siRNAs

Collaborating organization: NanoValent Pharmaceuticals, InC.
(<http://www.nanovalent.com/>)

Research Goal: Translate therapeutic siRNA, imaging agents and drugs to
neuroblastoma.

######## Teaching Experience:

##### Dates Title &Program Position

08/93-05/95 General Pediatrics Clinical Lecturer

> Medical Students & Nurses
>
> Cambridge University, UK

1994-95 Internal Medicine Clinical Supervisor

Medical Students

> Cambridge University, UK

2001- Pediatric Hematology Oncology Lecturer & Attending

Fellowship Training

###  

### Trainees: Past

+----------------+----------------+----------+-----------------------+
| **Name**       | **Position**   | #####    | **Current Position**  |
|                |                | Duration |                       |
+----------------+----------------+----------+-----------------------+
| Alicia Faller  | Pre-IRTA       | 06/      | Physician, Emergency  |
|                |                | 98-07/99 | Medicine              |
|                |                |          |                       |
|                |                |          | Mercy Hospital,       |
|                |                |          | Portland, Maine       |
+----------------+----------------+----------+-----------------------+
| Lao Saal       | Technical-IRTA | 04/      | M.D. Ph.D. student    |
|                |                | 98-07/00 |                       |
|                |                |          | Columbia University   |
+----------------+----------------+----------+-----------------------+
| David          | Pre-IRTA       | 09/      | Pediatric             |
| Clendenin      |                | 00-11/00 | Anesthesiologist      |
|                |                |          |                       |
|                |                |          | Boston Children\'s    |
|                |                |          | Hospital, Boston, MA  |
+----------------+----------------+----------+-----------------------+
| Jun Wei        | Post Doctoral  | 10/      | Biologist             |
|                | Fellow         | 99-05/01 |                       |
+----------------+----------------+----------+-----------------------+
| Len, Hua       | Post Doctoral  | 06/      | Optometry Student,    |
|                | Fellow         | 02-02/04 | The New England       |
|                |                |          | College of Optometry  |
+----------------+----------------+----------+-----------------------+
| Nicola         | Post Doctoral  | 08/      | Fellow Imperial       |
| Cenacchi       | Fellow         | 01-08/04 | College,              |
|                |                |          |                       |
|                |                |          | London                |
+----------------+----------------+----------+-----------------------+
| Roberta        | Post Doctoral  | 08/      | Post Doctoral Fellow  |
| Sartini        | Fellow         | 01-12/01 |                       |
|                |                |          | Italy                 |
+----------------+----------------+----------+-----------------------+
| Chang-gue Son  | Post Doctoral  | 04/      | Associate Professor,  |
|                | Fellow         | 02-08/04 | Daejeon University,   |
|                |                |          | Korea                 |
+----------------+----------------+----------+-----------------------+
| Alexei         | Post Doctoral  | 08/      | Staff Scientist,      |
| Krasnoselsky   | Fellow         | 02-08/04 |                       |
|                |                |          | Fred Hutchinson       |
|                |                |          | Cancer Center,        |
|                |                |          | Seattle               |
+----------------+----------------+----------+-----------------------+
| Craig          | Biologist      | 05/      | Senior Scientist, BD  |
| Whiteford      |                | 01-12/04 | Diagnostics           |
+----------------+----------------+----------+-----------------------+
| Braden Greer   | P              | 31/      | Seminary,             |
|                | rogrammer-SAIC | 02-08/05 | Gaithersburg, MD      |
+----------------+----------------+----------+-----------------------+
| Quangeng Zhang | Post Doctoral  | 05/      | Associate Professor,  |
|                | Fellow         | 05-12/06 | Capital Medical Uni., |
|                |                |          | Beijing, China,       |
+----------------+----------------+----------+-----------------------+
| Sven Bilke     | Post Doctoral  | 07/      | Staff Scientist,      |
|                | Fellow         | 02-01/07 | Cancer Genetic        |
|                |                |          | Branch, CCR, NCI, NIH |
+----------------+----------------+----------+-----------------------+
| Steffen        | Post Doctoral  | 06/      | Post Doctoral Fellow  |
| Durinck        | Fellow         | 06-07/01 |                       |
|                |                |          | Lawrence Livermore,   |
|                |                |          |                       |
|                |                |          | UC Berkley            |
+----------------+----------------+----------+-----------------------+

### 

### Trainees: Current

+--------------------+--------------------+---------------------------+
| **Name**           | **Position**       | ##### Duration            |
+--------------------+--------------------+---------------------------+
| Jun Wei            | Biologist          | 05/01-current             |
+--------------------+--------------------+---------------------------+
| Qingrong Chen      | Programmer Analyst | 11/05-current             |
+--------------------+--------------------+---------------------------+
| Xinyu Wen          | Programmer Analyst | 05/06-current             |
+--------------------+--------------------+---------------------------+
| Young Song         | Biologist          | 02/05-current             |
+--------------------+--------------------+---------------------------+
| Adam Cheuk         | Post Doctoral      | 07/05-current             |
|                    | Fellow             |                           |
+--------------------+--------------------+---------------------------+
| Patricia Tsang     | Post Doctoral      | 07/06-current             |
|                    | Fellow             |                           |
+--------------------+--------------------+---------------------------+
| Peter Johannson    | Post Doctoral      | 09/07-Current             |
|                    | Fellow             |                           |
+--------------------+--------------------+---------------------------+
| Belhu Metaferia    | Research Fellow    | 08/07-Current             |
+--------------------+--------------------+---------------------------+
| Jinesh Gheeya      | Post Doctoral      | 10/07-Current             |
|                    | Fellow             |                           |
+--------------------+--------------------+---------------------------+
| Jharna Barman      | Pre Doctoral       | 03/08- Current            |
|                    | Fellow             |                           |
+--------------------+--------------------+---------------------------+
| Wesley Beckstead   | Graduate Student   | To begin on 05/08         |
+--------------------+--------------------+---------------------------+

##### Evaluative and Editorial Positions:

1999-2001 Protocol Review Committee, Pediatric Oncology Branch, NCI, NIH

02/2001- 02/2002 Institutional Review Board, NHGRI, NIH

02/2001- Current Microarray Steering Committee, National Cancer
Institute, NIH

2002-Current The Bioinformatics, Biostatistics, and Computational
Biology Steering

> Committee

2004-Current Pediatric Drug Development Group (PedDDG) of Pediatric
Preclinical Testing Program (PPTP)

2004-Current Research Technology Program Review Committee, National
Cancer Institute.

2005-2007 Associate Editor, Cancer Research

2005-06 CCR Grand Rounds Planning Committee

2006 Fellows Award for Research Excellence (FARE) Judge, NIH

2006 AACR Program Committee (Gene Regulation and Transcription Factors
Subcommittee of the Cellular and Molecular Biology Section

2006 Co-Chair Mini-symposium Gene Regulation and Transcription Factors:
Gene and RNA Networks

2006 Quinquennial Review of Institute of Cancer Research, London, UK.
Site Visit Team, Reviewer.

2006 Reviewer and moderator at Advances in Neuroblastoma Research,
Molecular Cell Biology, Plenary Session, LA, USA

06/2007 2007 ASCO Annual Meeting Faculty, Scientific Discussant
Pediatric Cancers

2007 AACR Program Committee Member

2007-Current TCGA Data Access Committee

2005-2007 Dissertation Committee for Gabriel S. Eichler, Ph.D. Candidate
in Bioinformatics, Boston University

2007 Strategic Planning Committee to Interrogate the Molecular Genetics
of Cancer for Center for Cancer Research, NCI

2007-Current The Center of Excellence in Integrative Cancer Biology and
Genomics Steering Committee. Co-Chair of Integrative Systems Biology and
Bioinformatics Subcommittee, NCI

2007-Current Adjunct Investigator, Center for Cancer Research
Nanobiology Program

2007- Current Advances in Neuroblastoma Research Advisory Board

2008-Current International Panel Member of Cancer Research UK\*
Translational Research in Clinical Trials Committee (TRICC)

2008 Chair of Workshop on Translational Omics in Neuroblastoma, Chiba,
Japan

##### Book Editor

The Applications of Bioinformatics in Cancer Detection (2004)

Editors: Asad Umar, Izet Kapetanovic, and **Javed Khan**

Annals of New York Academy Of Sciences

### 

### Reviewer for Books & Journals:

> Cancer Research, Clinical Cancer Research, Molecular Cancer
> Therapeutics, Genomics, Cytometry, Genes Chromosomes and Cancer, Human
> Molecular Genetics, Cytogenetics and Cell Genetics, Genome Research,
> EMBO reports, Oncogene, Medical Pediatric Oncology, Journal of the
> National Cancer Institute, New England Journal of Medicine

Cancer Cell

### Grant Reviews:

March, 1999 NIH, Seed Grant

January, 2000 New Zealand Medical Research Council

December, 2000 Fonds zur Fördeung der wissenschaftlichen Forschung

Austria

May, 2001 Samantha Dickson Research Trust, UK

2001-current Cancer Research Campaign, UK

March, 2003 SSS-Y-92S, NIH Study Section Reviewer

2005. Wellcome Trust

2006. Samantha Dickson Research Trust, UK

> 2006 Wellcome Trust
>
> 2006 ZRG1 GGG-T, NIH Study Section Reviewer
>
> 2007 Cancer Research UK

2008 Neuroblastoma Society, United Kingdom

2008 National Research Grant Proposal, Singapore

##### Investigator on Protocols of the Intramural Program, NIH:

1999 Protocol 99-C-0125: Associate Investigator

> "Osteosarcoma: Outcome of therapy based on histological response. A
> collaborative effort of the POB/NCI, Texas Children's Hospital and
> University of Oklahoma".

2000 Associate Investigator "A Phase I Trial and Pharmacokinetic Study
of R115777 in Pediatric Patients with Refractory Leukemias"

2007 Associate Investigator "A pilot study of tumor vaccination in
patients with neuroblastoma and pediatric sarcomas and altered t cell
homeostasis"

**PROFESSIONAL ACTIVITIES**

##### Society Membership

Member of the Royal College of Physicians, UK (Equivalent to Boards for
Pediatrics)

Member of American Association of Cancer Research

##### Organization of Conference 

2005 International Conference on Translational Genomics in Neuroblastoma
(TGIN).

2007 International Conference on Translational Genomics in
Neuroblastoma-2 (TGIN2) and Therapeutically Applicable Research to
Generate Effective Treatments (TARGET) Initiative.

**COLLABORATIONS**

**1. Carol J. Thiele Ph.D.**

Head, Cell & Molecular Biology Section. Pediatric Oncology Branch, CCR,
NCI

-   **Expression of splice variants of TRKB in neuroblastoma**

-   **Microarray analysis of the mechanism of action of TRKB**

**2. Timothy D. Veenstra, Ph.D.**

Director, Laboratory of Proteomics and Analytical Technologies

Mass Spectrometry Center and Biomedical Proteomics Program

NCI at Frederick

-   **Isotope-coded affinity tags (ICAT) analysis of, high risk
    neuroblastoma, a pilot study.**

**3. Stephen Chanock M.D.**

Head, Genomic Variation Section, Pediatric Oncology Branch, Advanced
Technology Center,

CCR, NCI

-   **Screening of common mutations in Neuroblastoma and
    Rhabdomyosarcoma**

-   **Mutational screen of miRNA in commonly deleted regions for
    Neuroblastoma**

**4. Chand Khanna, DVM, Ph.D.**

Senior Scientist, Pediatric Oncology Branch, CCR, NCI

-   **Microarray data analysis of dog normal and Osteosarcoma samples**

**5. Stephen Hewitt, M.D., Ph.D.,**

Head Tissue Array Research Program (TARP). Advanced Technology Center,
Laboratory of

Pathology, CCR, NCI

-   **Development of tissue and antibody arrays for pediatric
    Xenografts**

**6. Malcolm Smith, M.D., Ph.D**., CTEP, NCI & **Peter Houghton, PhD**.

St Jude\'s Children\'s Research Hospital

-   **Pediatric Oncology Preclinical Protein-Tissue Array Project
    (POPP-TAP)**

**7. A.D.J. Pearson M.D.**

Cancer Research UK Professor of Paediatric Oncology

Head of the Paediatric Section of the Institute of Cancer Research

Head of the Children's Clinical Unit of the Royal Marsden Hospital NHS
Trust

> Divisional Medical Director of Rare Cancers, Chairman of the SIOPEN
> and Co-Chair of INRG, London, United Kingdom

-   **Omics characterization neuroblastoma from Children\'s Cancer and
    Leukaemia Group, UK**

**8. William A. Weiss MD-PhD**

Associate Professor, Department of Neurology, UCSF, California

-   **Molecular characterization of neuroblastoma tumors from the MYCN
    transgenic model**

**9. Daniel Catchpoole, Ph.D.**

Tumour Bank, The Children\'s Hospital at Westmead, Westmead, Australia

-   **Microarray analysis of the small round blue cell tumors of
    childhood**

-   **Microarray analysis of acute lymphoblastic leukemia**

**10. Jason Shohet, MD, PhD**

Assistant Professor, Texas Children's Cancer Center, Baylor College of
Medicine

Houston, Texas

-   **The effect of MYCN on microRNA expression profiles**

**11. Peter Ambros Ph.D.**

Associate Professor, Children's Cancer Research Institute, Vienna,
Austria

-   **Molecular characterization of neuroblastoma cell lines**

##### Invitations to Lecture

1991 **"Widespread Gas Gangrene in a Child with T-Cell Acute
Lymphoblastic Leukaemia"**

> Medical Grand Round, Addenbrooke's Hospital, Cambridge, UK

1992. **"Emergencies in Paediatric Oncology"**

> Regional Study day in Oncology, Shared Care Hospitals East Anglia, UK.

1992 **"Accuracy of The Detection of Immunity to Chicken Pox and Measles
in Childhood Malignancies"**

> United Kingdom Childhood Cancer Study Group, Newcastle, UK

1993 **"Prophylactic Antibiotics in Profound Neutropaenia"**

> United Kingdom Childhood Cancer Study, Cardiff, UK

1995 **"Comparative Genomic Hybridization a New Tool for the Molecular
Biologist"**

> Scientific Plenary Session, British Paediatric Association Annual
> Meeting
>
> University of York, UK

1998 **"Elucidation of Gene Expression Profiles in Cells Containing the
Tumor Specific Chromosome Translocation t(2;13)(q35:q14) using cDNA
Microarrays"**

> AACR 89^st^ Annual Meeting, New Orleans, Louisiana, USA

1998 **"Gene Expression Profiling of Alveolar Rhabdomyosarcoma with cDNA
Microarrays"**

> National Human Research Institutes, Annual Scientific Retreat, Airlie,
> Virginia, USA

1988 **"Elucidation of Gene Expression Profiles in Cells Containing the
Tumor Specific Chromosome Translocation t(2\[;13)(q35:q14) Using cDNA
Microarrays"**

> DNA Microarrays. Current Technology and Future Application Workshop
>
> Food and Drug Administration, Bethesda, MD, USA

1998. **"Elucidation of Gene Expression Profiles in Human Disease using
      cDNA Microarrays**"

> CRC Human Cancer Genetics Group, Cambridge University, UK

1999 **"Elucidation of Gene Expression Profiles in Cells Containing the
Tumor Specific Chromosome Translocation t(2;13)(q35:q14) Using cDNA
Microarrays"**

> AACR 90^st^ Annual Meeting Philadelphia, PA, USA.

##### 

##### 03/1999 "cDNA microarray analysis of human cancer"

> The Academy of Finland, Helsinki, Finland.

04/1999 **"Functional Genomics and DNA Chip Technology; cDNA Microarray
Analysis of Human Cancer"**

> Korean Society of Medical Biochemistry and Molecular Biology, Seoul,
> Korea.

04/1999 **"cDNA microarray analysis of cancer"**

> Hematopoesis & Immunology Society, Johns Hopkins University School of
> Medicine, Baltimore. MD, USA.

10/1999 **"cDNA microarrays detect activation of a myogenic
transcription program by the Pax3-Fkhr fusion oncogene"**

Minisymposia into the Natural History of Human Disease by Microarray
Analysis. NIH Research Festival on Gene Therapy and Imaging, NIH,
Bethesda, MD, USA.

12/1999 **"cDNA Microarray Analysis of Human Cancer"**

> Howard University Cancer Center, Washington DC, USA.

##### 

##### 2/2000 "DNA Microarray Technology: The Anticipated Impact on the Study of Human Disease"

> 21st Lorne Genome Conference, Lorne, Victoria, Australia.

05/2000 **"CDNA Micro Array Analysis of NYMC Over-Expressing NB Cells
and**

> **Retinoic Acid Treated NB Cells with Decreased NMYC Reveals Novel
> Putative NYMC Regulated Genes"**

Advances in Neuroblastoma Research 2000, Philadelphia, PA, USA

05/2000 **"Analysis of Gene Expression"**

> Eli Lilly workshop on Recombinant DNA technology. Emerging paradigms
> in biotechnology. Indianapolis, IN, USA.

06/2000 **"Molecular Classification of Human Cancer using cDNA
Microarrays"**

7th Workshop and Conference on Human Leucocyte Differentiation

> Antigens, Harrogate, UK.

07/2000 **"Molecular Classification of Human Cancer using cDNA
Microarrays"**

Gene Expression and Genomics Interest Group, NIA, NIH, Baltimore, USA.

10/2000 **"Molecular Classification and Gene Expression Profiling of
Paediatric Malignancies Using cDNA microarrays"**

32^nd^ Meeting International Society of Paediatric Oncology, Amsterdam,
Netherlands.

11/2000 **"Development of a Molecular Taxonomy of Small Blue Round-cell
Tumors using cDNA microarrays"**

> National Human Research Institutes, Annual Scientific Retreat, Airlie,
> Virginia, USA

12/2000 **"Development of a Molecular Taxonomy of Paediatric
Malignancies using cDNA microarrays"**

United Kingdom Childhood Cancer Study Group Annual Scientific Retreat

London, UK.

1/2001 **"Development of a Molecular Taxonomy of Pediatric Malignancies
using cDNA microarrays"**

Hematology and Oncology, Children's Hospital of Philadelphia, PA, USA

3/5/2001 **"Diagnostic Classification of Cancers Using cDNA microarrays
and Artificial Neural Networks"**

6^th^ Joint Meeting of the Board of Scientific Advisors and Board or
Scientific Counselors, NCI, NIH, Bethesda, MD, USA.

3/2001 **"Large Scale Gene Expression Profiling in Cancer Research"**

Educational Session, AACR 92^nd^ Annual Meeting. New Orleans, Louisiana,
USA.

11/2001 **"Classification and Diagnostic Prediction of Cancers using
Gene Expression Profiling and Artificial Neural Networks"**

16^th^ Annual Meeting of the Society of Biological Therapy, Bethesda,
MD, USA.

04/2002 **"Classification and Diagnostic Prediction of Cancers using
Gene Expression Profiling and Artificial Neural Networks"**

Annual Meeting of the Radiation Research Society, Reno, Nevada, USA.

04/2002 **"Molecular Characterization of Cancers with Microarrays"**

Children's Oncology Group, Jacksonville, FL, USA

04/2002 **"Classification and Diagnostic Prediction of Cancers using
Gene Expression Profiling and Artificial Neural Networks"**

Macroresults through Microarrays 2, Boston, MA, USA

08/2002 **"Characterization and Diagnosis of Cancer Using DNA
Microarrays and Artificial Neural Networks"**

Applications of Bioinformatics in Early Cancer Detection, National
Cancer Institute, Bethesda, MD, USA.

02/2003 **\"Past, Present and Future Technologies for Cancer
Research\"** Genomic & Proteomic Technological Advances in Cancer
Research Microarrays, Mass Spectrometry, Imaging and SNP Analysis in
Cancer Diagnosis, Prognosis, Prevention and Treatment. Bethesda, MD,
USA.

03/2003 **"Molecular Mining of Data Generated from Gene Expression
Profiling"**

Gordon Research Conference on Aging in Venture CA, USA

01/2004 **"Application of Genomics and Artificial Neural Networks for
the Investigation of Cancers".** Medical College of Wisconsin,
Department of Pediatrics, Children's Hospital of Wisconsin, WI, USA

06/2004 **"Application of Genomics for the Investigation of Pediatric
Cancers".** University of Bologna, Italy

06/2004 **" Application of Genomics and Artificial Neural Networks for
the Investigation of Cancers".** Birmingham Children's Hospital,
Birmingham, UK

06/2004 **"Application of Genomics and Artificial Neural Networks for
the Investigation of Cancers".** Birmingham University, Birmingham, UK

06/2004 **"CGH and Prognostic Prediction using cDNA Microarrays in
Neuroblastoma".** Dept of Child Health, The Royal Victoria Infirmary,
Newcastle, UK

06/2004 **" Application of Genomics and Artificial Neural Networks for
the Investigation of Cancers".** Institute of Cancer Research, Royal
Marsden Hospital, Sutton, UK

02/2005 **"The Applications of Microarrays and Artificial Intelligence
for Diagnosis, Predicting Prognosis and Selection of Therapeutic
Targets".** Center for Cancer Research, National Cancer Institute, NIH,
Bethesda, MD, USA

03/2005 **" Oncogenomics Section Database Development"** COG-BTRC Task
Force, San Diego, CA, USA

04/2005 **"Inferring Tumor Progression Models Using Array CGH Data".**
Agilent CGH Workshop, Anaheim, CA, USA

05/2005 **"The Applications of Microarrays and Artificial Intelligence
for Diagnosis and Predicting Prognosis".** Educational Session, American
Society of Clinical Oncology (ASCO) Annual Meeting, FL, USA

09/2005 **"Inferring Tumor Progression Models from Genomic data".**
1^st^ National Cancer Research Institute - Cancer Conference,
Birmingham, UK

09/2005 **"The Applications of Microarrays and Artificial Intelligence
for Diagnosis and Predicting Prognosis".** SIOP 2005: 37th Congress of
The International Society Of Paediatric Oncology. Vancouver, Canada

09/2005 **"Translational Genomics in Neuroblastoma".** Texas Children's
Hospital, Baylor School of Medicine.

03/2006 **"Translational Genomics in Neuroblastoma".** USCF, San
Francisco, CA, USA

04/2006 **"Cancer Genomics".** Surgeons Travel Club, Bethesda, MD, USA.

05/2006 **"Expression Profiling for Prognostication; Translation of
Genomics into Clinical Practice".** Advances in Neuroblastoma Research,
Los Angeles, CA, USA

07/2006 **"Neuroblastoma; An Enigmatic Lethal Tumor".** Targeted
Therapeutic Workshop, UICC, Washington DC, USA

07/2006 **"The Applications of Microarrays and Artificial Neural
Networks for Diagnosis, Predicting Prognosis and Selection of
Therapeutic Targets".** National Cancer Advisory Board, NCI, Bethesda.
MD, USA

10/2006 **"Translational "Omics" in Cancer".** Grand Round, Center for
Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA

10/2006 **"DNA copy number changes as potential markers for
prognostication".** The SIOP European Neuroblastoma Research Network,
Stockholm, Sweden

10/2006 **"What we can learn from gene expression microarray data".**
The SIOP European Neuroblastoma Research Network, Stockholm, Sweden

12/2006 **"Translation of Genomics to the Clinic".** Presentation to NIH
director Dr Zerhouni's visit to the CCR, NCI

12/2006 **"Molecular Diagnosis of Cancer in the 21st Century and
Beyond:**

> **From Genes to Nanochips".** Presentation to Senator Kennedy's Visit
> to NIH

01/2007 **"Neuroblastoma; an Enigmatic Lethal Tumor".** St. Baldrick's
Foundation, New York, USA

02/2007 **"The NanoBioSensor Initiative: Thinking Outside of the Box."**
Graduate and Undergraduate Program, Department of Electrical and
Computer Engineering University of Maryland, College Park, MD, USA

09/2007 **"Translational "Omics" in Pediatric Cancer; What next?**"
Children\'s Cancer Research Institute University of Texas Health Science
Center at San Antonio, TX, USA

11/2007 **"mRNA as Biomarkers in Cancer** ". EORTC-NCI-ASCO Meeting ,
Belgium

12/2007 **"Translational "Omics" in Pediatric Cancer**". Greehey
Children\'s Cancer Research Institute University of Texas Health Science
Center at San Antonio

12/2007 **"Translational "Omics" in Neuroblastoma**". St. Jude
Children\'s Research Hospital, Memphis, Tennessee, USA

01/2008 **"Translational "Omics" in Neuroblastoma**". Visit by French
Delegation to NIH, representative of CCR.

02/2008 **"The NanoBioSensor Initiative**". Nanobiology Seminar Series,
NCI, Frederick, MD

03/2008 **"Translational Genomics in Neuroblastoma. The Vision**".
International Neuroblastoma Symposium. Texas Children's Hospital,
Texas,USA

05/2008 **"Translational Omics in Neuroblastoma**" Advances in
Neuroblastoma Research 2008. Chiba, Japan.

##### 05/2008 "*MYCN* is a direct target of microRNA 34a". Chosen for plenary session lecture and received best paper award. Chiba, Japan 

##### Publications

**Research Articles**

1.  [**Khan, J.**,]{.underline} Broadbent, V.A. (1993). **Tumour lysis
    syndrome complicating treatment of widespread metastatic abdominal
    rhabdomyosarcoma**.

Paediatric Haematology and Oncology. 10:151.

2.  Coleman, N., Spiers, G., **[Khan, J]{.underline}.,** Broadbent,
    V.A., Warren, R. (1993). **Clostridium tertium neutropaenic
    enterocolitis.**

Journal of Clinical Pathology. 46:180-183.

3.  Stephenson, T. and **[Khan, J]{.underline}**. (1993**). A new
    technique for the placement of central venous catheters in small
    infants.**

Journal of Parenteral and Enteral Nutrition. 17,5: 479-481.

4.  Park, M,K., **[Khan, J]{.underline}.**, Stock, F., Lucey, D.R.,
    (1997). **Successful treatment of Stomatococcus mucilaginosus
    meningitis with intravenous vancomycin and intravenous**
    **ceftriaxone.** Clinical Infectious Diseases*. Feb;24(2):278.*

5.  **[Khan, J]{.underline}**., Parsa, N.Z., Harada, T., Meltzer, P.S.
    and Carter N. (1998). **Detection of Gains and Losses in 18
    Meningiomas by Comparative Genomic Hybridization**

> Cancer Genetics Cytogenetics. 102: 1-5.

6.  [**Khan, J.**,]{.underline} Simon, R., Bittner, M., Chen, Y.,
    Leighton, S.B., Pohida, T., Smith, P.D., Jiang, Y., Gooden, G.C.,
    Trent, T.M. and Meltzer PS. (1998). **Gene Expression Profiling of
    Alveolar Rhabdomyosarcoma with cDNA Microarrays**

> Cancer Research 58, 5009-5013.

7.  **[Khan, J]{.underline}**., Bittner, M.L, Saal, L.H, Azorsa, D.A.,
    Teichman, U., Pavan, W., Trent, J.M., Meltzer, P.S. (1999). **cDNA
    microarrays detect activation of a myogenic transcription program by
    the Pax3-FKHR fusion oncogene.**

> Proceedings of the National Academy of Sciences 96 , 23, 13264-13269.

8.  Heiskanen, M.A., Bittner, M.L., Chen, Y, **[Khan, J]{.underline}.**,
    Adler, K. E., Trent, J.M. and Meltzer PS. (2000). **Detection of
    Gene Amplification by Genomic Hybridization to cDNA Microarrays.**

> Cancer Research 60, 799-802.

9.  Dupont, J., **[Khan, J.,]{.underline}** Qu, B.H., Meltzer, P.,
    Helman., L. LeRoith, D. (2001). **Insulin and IGF-1 Induce Different
    Patterns of Gene Expression in Mouse Fibroblast NIH-3T3 Cells:
    Identification by cDNA Microarray Analysis.**

> Endocrinology 142(11): 1512-9

10. Khanna, C., [**Khan, J**.,]{.underline} Nguyen, P., Prehn, J.,
    Caylor, J., Yeung, C., Trepel, J., Meltzer, P., and Helman, L.
    (2001). **Metastasis Associated Differences in Gene Expression in a
    Murine Model Osteosarcoma** .Cancer Research 61, 3750-9.

11. **[Javed Khan]{.underline}**, Jun S. Wei, Markus Ringnér, Lao H.
    Saal, Marc Ladanyi, Frank Westermann , Frank Berthold, Manfred
    Schwab, Cristina R. Antonescu, Carsten Peterson, and Paul S.
    Meltzer. (2001). **Classification and Diagnostic Prediction of
    Cancers using Gene Expression Profiling and Artificial Neural
    Networks**

> Nature Medicine. Vol. 7,6; 673-679

12. Dickens DS, Kozielski R**, [Khan J]{.underline}**[,]{.underline}
    Forus A, Cripe TP. (2002). Cyclooxygenase-2 **Expression in
    Pediatric Sarcomas.**

> Pediatr Dev Pathol May 24;5(4)

13. Rice AM, Currier MA, Adams LC, Bharatan NS, Collins MH, Snyder JD,
    **[Khan J]{.underline}**, Cripe TP.(2002). **Ewing sarcoma family of
    tumors express adenovirus receptors and are susceptible to
    adenovirus-mediated oncolysis**.

> J Pediatr Hematol Oncol Oct;24(7):527-33

14. Zuyi Wang, Yue Wang, Jianping Lu, Sun-Yuan Kung, Junying Zhan1,
    Richard Lee, Jianhua Xua1, Javed Khan and Robert Clarke (2003)
    **Discriminatory Mining of Gene Expression Microarray Data.**
    Journal of VLSI Signal Processing System. 35;3 Pages: 255 - 272

15. Bomprezzi R, Ringner M, Kim S, Bittner ML, **[Khan J]{.underline}**,
    Chen Y, Elkahloun A, Yu A, Bielekova B, Meltzer PS, Martin R,
    McFarland HF, Trent JM (2003). **Gene expression profile in multiple
    sclerosis patients and healthy controls: identifying pathways
    relevant to disease.**

Hum Mol Genet. Sep 1;12(17):2191-9.

16. Yu Y, **[Khan J]{.underline},** Khanna C, Helman L, Meltzer PS,
    Merlino G. (2004). Discriminatory **Expression profiling identifies
    the cytoskeletal organizer ezrin and the developmental homeoprotein
    Six-1 as key metastatic regulators.** (Equal first author).

> Nature Medicine 2004 Jan 4, Vol. 10(2):175-81

17. Richard Despar, **[Javed Khan]{.underline}**, and Alejandro Schaffer
    (2004). **Tumor Classification Using Phylogenetic Methods on
    Expression Data.** J Theor Biol. Jun 21;228(4):477-96.

18. Richard D Williams, Sandra Hing, Braden T Greer, Craig C Whiteford,
    Jun S Wei, Rachael Natrajan, Anna Kelsey, Simon Rogers, Colin
    Campbell, Kathy Pritchard-Jones and **[Javed Khan.]{.underline}**
    (2004). **Prognostic Classification of Relapsing Favourable
    Histology Wilms Tumour using cDNA Microarray Expression Profiling
    and Support Vector Machines.** Genes Chromosomes and Cancer.
    Sep;41(1):65-79.

19. Jun S. Wei, Braden T. Greer, Frank Westermann, Seth M. Steinberg,
    Chang-Gue Son, Qing-Rong Chen, Craig C. Whiteford, Sven Bilke,
    Alexei L. Krasnoselsky, Nicola Cenacchi, Daniel Catchpoole, Frank
    Berthold, Manfred Schwab, and **[Javed Khan]{.underline}** (2004).
    **Prediction of clinical outcome using gene expression profiling and
    artificial neural networks for patients with neuroblastoma.**

> Cancer Research Oct 1, 2004; 64(19).

20. Chen QR, Bilke S, Wei JS,Whiteford CC, Cenacchi N, Krasnoselsky AL,
    Greer BT, Son C, Westermann F, Berthold F, Schwab M, Catchpoole D,
    **[Khan J]{.underline}**. (2004). **cDNA array-CGH profiling
    identifies genomic alterations specific to stage and
    MYCN-amplification in neuroblastoma.** BMC Genomics, 5:70

21. Sven Bilke, Qing-Rong Chen, Craig C. Whiteford, **[Javed
    Khan]{.underline}**. (2005). **Detection of low level genomic
    alterations by comparative genomic hybridization based on cDNA
    micro-arrays.** Bioinformatics 21 (7): 1138-1145 Apr 1

22. Alexei L. Krasnoselsky, Craig C. Whiteford, Jun S. Wei, Sven Bilke,
    Frank Westermann, Qing-Rong Chen, and **[Javed Khan
    (]{.underline}**2005). **Prognostic Classification of Relapsing
    Altered expression of cell cycle genes distinguishes aggressive
    neuroblastoma**

> Oncogene. Feb 24;24(9):1533-41..

23. Chang Gue Son, Sven Bilke, Sean Davis, Braden T. Greer, Jun S. Wei,
    Craig C. Whiteford, Qing-Rong Chen, Nicola Cenacchi, and **[Javed
    Khan]{.underline}** **[(]{.underline}**2005). **Database of mRNA
    Gene Expression Profiles of Multiple Human Organs**

> Genome Res 15 (3): 443-450 Mar

24. Kim HS, Choi EH, **[Khan J]{.underline}**, Roilides E, Francesconi
    A, Kasai M, Sein T, Schaufele RL, Sakurai K, Son CG, Greer BT,
    Chanock S, Lyman CA, Walsh TJ. (2005). **Expression of genes
    encoding innate host defense molecules in normal human monocytes in
    response to Candida albicans.**

> Infect Immun. Jun;73(6):3714-24.

25. Jun S. Wei, Craig C. Whiteford, Nicola Cenacchi, Chang Gue Son, and
    **[Javed Khan]{.underline}**.(2005**). BBC3 Mediates
    Fenretinide-Induced Cell Death in Neuroblastoma.**

> Oncogene. 2005 Aug 8

26. Amir A. Jazaeri, Christopher S. Awtrey, Gadisetti V. R.,
    Chandramouli, Yao Eric Chuang, **[Javed Khan]{.underline}**,
    Christos Sotiriou, Olga Aprelikova, Cindy J. Yee, Kristin K. Zorn,
    Michael J. Birrer, J. Carl Barrett, and Jeff Boyd. (2005) **Gene
    Expression Profiles Associated with Response to Chemotherapy in
    Epithelial Ovarian Cancers**.

> Clin Cancer Res. 2005 Sep 1;11(17):6300-10

27. Sven Bilke, Qing-Rong Chen, Frank Westerman, Manfred Schwab, Daniel
    Catchpoole, and **[Javed Khan]{.underline}** (2005) **Inferring a
    Tumor Progression Model for Neuroblastoma From Genomic Data**
    Journal of Clinical Oncology Oct; 23:7322-31

28. Henrich KO, Fischer M, Mertens D, Benner A, Wiedemeyer R, Brors B,
    Oberthuer A, Berthold F, Wei JS, **[Khan J]{.underline},** Schwab M,
    Westermann F. (2006) **Reduced expression of CAMTA1 correlates with
    adverse outcome in neuroblastoma patients.**

> Clin Cancer Res. 2006 Jan 1;12(1):131-8.

29. Chen, Sven Bilke, Jun S. Wei, Braden T. Greer, Seth M. Steinberg,
    Frank Westermann, Manfred Schwab, and **[Javed
    Khan]{.underline}** (2006) **Increased WSB1 Copy Number Correlates
    with its Over-expression which Associates with Increased Survival in
    Neuroblastoma. Genes Chromosomes and Cancer.** Genes Chromosomes
    Cancer. 2006 Sep;45(9):856-62.

30. Houghton PJ, Morton CL, Tucker C, Payne D, Favours E, Cole C,
    Gorlick R, Kolb EA, Zhang W, Lock R, Carol H, Tajbakhsh M, Reynolds
    CP, Maris JM, Courtright J, Keir ST, Friedman HS, Stopford C,
    Zeidner J, Wu J, Liu T, Billups CA, **[Khan J]{.underline}**, Ansher
    S, Zhang J, Smith MA (2007). **The pediatric preclinical testing
    program: Description of models and early testing results.** Pediatr
    Blood Cancer. 2007 Dec;49(7):928-40.

31. Craig C. Whiteford, Sven Bilke, Braden T. Greer, Qingrong Chen,
    Till A. Braunschweig, Nicola Cenacchi, Jun S. Wei, Malcolm A. Smith,
    Peter Houghton, Christopher Morton, C. Patrick Reynolds, Richard
    Lock, Richard Gorlick, Chand Khanna, Carol J. Thiele, Mikiko
    Takikita, Daniel Catchpoole, Stephen M. Hewitt and [**Javed
    Khan**]{.underline} (2007). **Credentialing Preclinical Pediatric
    Xenograft Models Using Gene Expression and Tissue Microarray
    Analysis.** Cancer Res. 2007 Jan 1;67(1):32-40.

32. Qing-Rong Chen, Gordon Vansant, Kahuku Oades, Maria Pickerin, Jun S.
    Wei, Young K. Song, Joseph Monforte and **[Javed
    Khan]{.underline}** (2007) **Diagnosis of the Small Round Blue Cell
    Tumors using Multiplex PCR.** J Mol Diagn. 2007, 9:80-88.

33. Jin Zheng, M. Eric Kohler, Qingrong Chen, James Weber, **[Javed
    Khan]{.underline}**, Bryon D Johnson, Rimas J Orentas (2007) **Serum
    from mice immunized in the context of Treg inhibition identifies DEK
    as a neuroblastoma tumor antigen**. BMC Immunology, 8:4 (30 March
    2007)

34. Jianhua Xuan, YueWang, Yibin Dong, Yuanjian Feng, BinWang, **[Javed
    Khan]{.underline}**, Maria Bakay, Zuyi Wang,, Lauren Pachman,
    SaraWinokur, Yi-Wen Chen, Robert Clarke, and Eric Hoffman (2007)
    **Gene Selection for Multiclass Prediction by Weighted Fisher
    Criterion.** EURASIP Journal on Bioinformatics and Systems Biolog.
    Volume 2007, Article ID 64628,

35. FrankWestermann, Kai-Oliver Henrich, Jun S.Wei, Werner Lutz,
    Matthias Fischer, Rainer Koinig, RuprechtWiedemeyer, Volker Ehemann,
    Benedikt Brors, Karen Ernestus, Ivo Leuschner, Axel Benner, **[Javed
    Khan]{.underline}**, and Manfred Schwab (2007). **High Skp2
    Expression Characterizes High-Risk Neuroblastomas Independent of
    MYCN Status.** Clinical Cancer Research Aug 15;13(16):4695-703. Epub
    2007 Jul 25.

36. Catchpoole D, Lail A, Guo D, Chen QR, **[Khan J.]{.underline}**
    (2007). Gene expression profiles that segregate patients with
    childhood acute lymphoblastic leukaemia: **An independent validation
    study identifies that endoglin associates with patient outcome**.
    Leuk Res. 2007 Dec;31(12):1741-7. Epub 2007 Jun 18.

37. Geoffrey Neale, Xiaoping Su, Christopher L. Morton, Doris Phelps,
    Richard Gorlic, Richard Lock, C. Patrick Reynolds, John M. Maris,
    Henry S. Friedman, Jeffrey Dome, Joseph Khoury, Timothy J. Triche,
    Robert C. Seeger, Richard Gilbertson, **[Javed Khan]{.underline}**,
    Malcolm A. Smith, Peter J. Houghton (2008). **Molecular
    Characterization of the Pediatric Preclinical Testing Panel.**
    Clinical Cancer Research In Press

38. J S Wei, Y K Song, S Durinck, Q-R Chen, A T C Cheuk, P Tsang, Q
    Zhang, C J Thiele, A Slack, J Shohet and **[J Khan]{.underline}**
    (2008). **The MYCN oncogene is a direct target of miR-34a.**
    Oncogene. .Advance online publication 26 May 2008.

39. Kowalska A, Brunner B, Bozsaky E, Chen QR, Stock C, Lörch T, **[Khan
    J]{.underline}**, Ambros PF (2008). **Sequence based high resolution
    chromosomal CGH.** Cytogenet Genome Res. 121(1):1-6. Epub 2008 May
    7.

40. Sven Bilke, Qing-Rong Chen, Jun S. Wei, and **[Javed
    Khan]{.underline}** (2008). **Whole Chromosome alterations predict
    survival in high risk neuroblastoma without MYCN amplification.**
    Clinical Cancer Research. In Press.

41. Qing-Rong Chen, Young K. Song, Jun S. Wei, Sven Bilke, Shahab
    Asgharzadeh, Robert C. Seeger and **[Javed Khan]{.underline}**
    (2008). **An Integrated Cross-Platform Prognosis Study on
    Neuroblastoma Patients.** Genomics. In Press.

**Conference Papers**

1.  Y. Wang, J. Zhang, K. Huang, **[J. Khan]{.underline}**, and Z.
    Szabo (2002) **Independent component imaging of disease
    signatures.** Proc. IEEE Intl Symp. Biomed. Imaging, pp. 178-181,
    Washington, DC, July 2002

2.  J. Zhang, K. Huang, **[J. Khan]{.underline}**, K. Li, Z.
    Bhujwalla, R. Clarke, Z. Gu, Z. Szabo, J. Xuan, and Y. Wang,
    **Computational decomposition of molecular signatures.** (2002).
    Proc. Intl Conf. Diagnositic Imaging and Analysis, pp. 312-317,
    Shanghai, August 2002.

3.  Yue Wang, Junying Zhang, **[Javed Khan]{.underline}**, Clarke, R,
    Zhiping Gu. (2002). **Partially-independent component analysis for
    tissue heterogeneity correction in microarray gene expression
    analysis.** Biomedical Imaging.

> Proceedings. 2002 IEEE International Symposium. Pages 457- 460

4.  Zuyi Wang, Sun-Yuan Kung, Junying Zhang, **[Javed
    Khan]{.underline}**, Jianhua Xuan, Yue Wang. (2003) **Computational
    intelligence approach for gene expression data mining and
    classification**. Multimedia and Expo,. ICME \'03. Proceedings.
    International Conference Volume: 3, On page(s): III- 449-52 vol.3

5.  Y. Wang, J. Zhang, **[J. Khan]{.underline}**, R. Clarke, and Z. Gu.
    **Partially-independent component analysis for tissue heterogeneity
    correction in microarray gene expression analysis.** (2003) Proc.
    IEEE Workshop on Neural Networks for Signal Processing, Toulouse,
    France, Sept. 2003.

6.  J. Xuan, Y. Dong, **[J. Khan]{.underline}**, R. Clarke, E. Hoffman
    and Y. Wang (2004), **Gene Selection by Weighted Fisher Criterion
    for Multiclass Prediction.** Proc. Intl Conf. Bioinformatics and
    Applications, pp. 252-263, Fort Lauderdale, Florida, Dec. 2004.

7.  Y. Wang, Z. Wang, J. Xuan, E. Hoffman, R. Clarke, and **[J.
    Khan]{.underline}** (2004). **Optimizing Multilayer Perceptrons By
    Discriminatory Component Analysis.** Proc. IEEE Intl Workshop
    Machine Learning for Signal Processing, pp. 273-282, Sao Luis,
    Brazil, Sept. 2004.

8.  J. Xuan, Y. Dong, **[J. Khan]{.underline}**, E. Hoffman, R. Clarke,
    and Y. Wang. **Robust Feature Selection by Weighted Fisher Criterion
    for Multiclass Prediction in Gene Expression Profiling.** (2004)
    Proc. Intl Conf. Pattern Recognition, vol. 2, pp. 291-294,
    Cambridge, UK, Aug. 2004.

9.  Konrad H. Aschenbach , Herman Pandana, Jookyung Lee, **[Javed
    Khan]{.underline}**, Michael Fuhrer, Dan Lenski and R.D. Gomez.
    Detection of Nucleic Acid hybridization via Oxide-Gated Carbon
    Nanotube Field-Effect Transistors. SPIE_6959-31

10. Herman Pandana, Konrad H. Aschenbach, Daniel R. Lenski, Michael S.
    Fuhrer, **[Javed Khan]{.underline}**, and Romel D. Gomez. A
    Versatile Biomolecular Charge Based Sensor Using Oxide-Gated Carbon
    Nanotube Transistor Arrays.

**Review Articles and Book Chapters**

1.  [**Khan, J**.,]{.underline} Ross-Russell, R. (1993). **Paediatric
    resuscitation**.

> Current Paediatrics. 3:220-224.

2.  [**Khan, J**.,]{.underline} Saal, L.H.,Bittner, M.L., Chen, Y.,
    Trent, J.M., and Meltzer, P.S. (1999). **Expression Profiling in
    Cancer using cDNA Microarrays**.

> Electrophoreses 20, 223-229.

3.  [**Khan, J**.,]{.underline} Bittner, M.L., Chen, Y., Trent, J.M.,
    and Meltzer, P.S. (1999). DNA **Microarray Technology: The
    Anticipated Impact on the Study of Human Disease**. Biochimica et
    Biophysica Acta. 1423 M17-M28.

4.  **[Khan, J]{.underline}**.and Meltzer, P.S.

> **Expression Profiling in Cancer Using cDNA Microarrays**.

###### The Molecular Analysis of Cancer, Methods in Molecular Biology. Humana Press (2001).

5.  [**Khan, J**.]{.underline} and Meltzer, P.S. (2002)

> **cDNA Microarray Analysis of Human Cancer**.

###### FISH A Practical Approach. Oxford University Press

6.  Whiteford, C. C., Wei, J. S., **[Khan, J.]{.underline}** (2003)

> **Genomics, Protenomics and Microarray Analysis**.
>
> The UICC Manual of Clinical Oncology, 8^th^ Edition.

7.  Wei, J. S. and **[Khan, J.]{.underline}** (2002)

> **DNA Arrays**
>
> 3^rd^ Edition of Molecular Cloning; A laboratory Manual.
>
> Cold Spring Harbor Laboratory Press.

8.  [**Khan J**,]{.underline} Saal LH, Bittner ML, Jiang Y, Gooden GC,
    Glatfelter AA, Meltzer PS. (2002)

> **Gene expression profiling in cancer using cDNA microarrays.**
>
> *Methods Mol Med 2002;68:205-22*

9.  Markus Ringnér, Carsten Peterson and **[Javed Khan]{.underline}**
    (2002)

> **Analyzing array data using supervised methods.**
>
> *Pharmacogenomics. 3 (3):403-415*

10. **[Javed Khan]{.underline}** and Marc Ladanyi (2003)

> **Classification of Pediatric Tumors using DNA Microarrays**
>
> *Expression Profiling of Human Tumors. Diagnostic and Research
> Applications. Humana Press.*

11. **[Javed Khan]{.underline}** (2003)

> **Genomic & Proteomic Technological Advances in Cancer Research.
> Conference Report**.
>
> *Pharmacogenomics*. 4 (3):245-249

12. Braden Greer and **[Javed Khan]{.underline}** (2004)

> **Microarray Analysis of Sarcomas.**
>
> Book Chapter in *Progress in ONCOLOGY*.

13. Braden Greer and **[Javed Khan]{.underline}** (2004)

> **Book Chapter: Diagnostic classification of cancer using DNA
> microarrays and artificial intelligence.**
>
> The Applications of Bioinformatics in Cancer Detection
>
> Annals Of New York Academy Of Sciences

14. Chen QR, Bilke S, [**Khan J**.]{.underline} (2005)

> **High-resolution cDNA microarray-based comparative genomic
> hybridization analysis in neuroblastoma**.
>
> *Cancer Lett. 2005 Oct 18;228(1-2):71-81.*

15. Braden Green and **[Javed Khan]{.underline}** (2007)

> **Book Chapter: Online analysis of microarray data using artificial
> neural networks.**
>
> ***Humana Press Inc**. Microarray Data Analysis: Methods and
> Applications. Methods Mol Biol. 2007;377:61-74.*

16. Sven Bilke and **[Javed Khan]{.underline}** (2007). **Book Chapter:
    Analysis of Comparative Genomic Hybridization Data on cDNA
    Microarrays.**

> ***Humana Press Inc**. Microarray Data Analysis: Methods and
> Applications. Methods Mol Biol. 2007;377:175-86.*