# **NCI Summer Curriculum in**

# **Cancer Prevention**

**\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\***

**Molecular Prevention Course**

### **July 31 through August 4, 2006**

**6001 Executive Boulevard**

**Conference Rooms C and D**

### **Rockville, Maryland 20852**

**301-435-1465**

#### Course Syllabus

**2006**

### *U.S. Department of Health and Human Services*

*National Institutes of Health*

### *National Cancer Institute*

*Division of Cancer Prevention*

####### Office of Preventive Oncology 

# NCI Summer Curriculum in Cancer Prevention

## Molecular Prevention Course

Date: July 31 through August 4, 2006

Time: 8:30 a.m. to 10:00 a.m.

10:30 a.m. to 12:00 noon

1:00 p.m. to 2:30 p.m.

(occasionally, lecture times will vary)

Each session has a different topic and speaker

Location: 6001 Executive Boulevard

Conference Rooms C and D

Rockville, Maryland 20852

301-435-1465

Course presented by:

Office of Preventive Oncology Douglas L. Weed, PhD, MD, MPH, Director

Division of Cancer Prevention Jackie A. Lavigne, PhD, MPH, Associate
Director

National Cancer Institute Graça M. Dores, MD, MPH, Associate Director

National Institutes of Health Trishna Dey, Program Specialist

EPN, Suite 321, MSC 7361 Lisa Poe, Program Specialist

6130 Executive Boulevard Bernice Roane, Administrative Assistant

Bethesda, Maryland 20892-7361 Valerie Russell, Summer Intern

Telephone: 301-496-8640

Fax: 301-402-4863

http://cancer.gov/prevention/pob

**Educational Objective**

The overall objective of the course is to provide specialized
instruction in principles of molecular biology as applied in the field
of cancer prevention. The course focuses on the concepts, methods,
issues, and applications of molecular biology in cancer prevention
efforts and genetics of cancer. Participants will have an opportunity to
gain a broad-based perspective of these subject areas, including basic
laboratory methodology and theory of how molecular techniques are
applied to molecular epidemiology, bionutrition, chemoprevention,
biomarkers, and translational research. Life-long learning skills
include critical appraisal of molecular approaches, methodologies, and
theories used in the field of cancer prevention.

The National Institutes of Health/Foundation for Advanced Education in
the Sciences (NIH/FAES) is accredited by the Accreditation Council for
Continuing Medical Education to provide continuing medical education for
physicians.

The target audiences are MD and PhD degree holders who also hold an MPH
degree, and were selected into the Cancer Prevention Fellowship Program,
and MD and PhD degree holders with an interest in cancer prevention and
control from the NIH and the NCI, national organizations, and foreign
institutions.

If you have a disability and require any assistive devices, services, or
other reasonable accommodations to participate in this activity, please
contact the Office of Preventive Oncology at 301-496-8640 at least 1
week in advance of the lecture date to discuss your needs.

NCI Summer Curriculum in Cancer Prevention and Control

Molecular Prevention Course

**Monday, July 31, 2006**

8:30 a.m. - 8:45 a.m. Introduction/Course Overview Jackie Lavigne, PhD,
MPH

8:45 a.m. - 10:30 a.m. Overview of Carcinogenesis Norman Hord, PhD, MPH,
RD

Break

11:00 a.m. - 12:30 p.m. Oncogenes, Tumor Suppressor Genes, and Michael
Birrer, MD, PhD

Other Cancer-Related Genes

12:30 Group Photo

Lunch

1:30 p.m. - 3:00 p.m. Animal Models for Cancer Prevention Studies
Jeffrey Green, MD

### **Tuesday, August 1, 2006**

8:30 a.m. - 10:00 a.m. Methylation as a Target for Chemoprevention Karen
Woodson, PhD, MPH

Break

10:30 a.m. - 12:00 noon Xenobiotic Metabolism and Cancer Susceptibility
Thomas Kensler, PhD

Lunch

1:00 p.m. - 2:30 p.m. Hormonal Carcinogenesis James D. Yager, PhD

### **Wednesday, August 2, 2006**

8:30 a.m. - 10:00 a.m. The Immune System as a Target for Vaccine John
Greiner, PhD

> and Prevention Approaches

Break

10:30 a.m. - 12:00 noon Cancer From a Biosystem Perspective J. Carl
Barrett, PhD

Lunch

1:00 p.m. - 2:30 p.m. The Role of Inflammation in Cancer Curtis Harris,
PhD

**[Thursday, August 3, 2006]{.underline}**

8:30 a.m. - 10:00 a.m. The Quest for New Molecular Targets for Patricia
Steeg, PhD

> Cancer Prevention and Treatment

Break

10:30 a.m. - 12:00 noon New Approaches to Imaging Cancer Processes Peter
Choyke, MD

########  In Vivo

Lunch

1:00 p.m. - 2:30 p.m. Application of Genomics and Proteomics to John
Weinstein, MD, PhD

Cancer Research

### **Friday, August 4, 2006**

8:30 a.m. - 9:30 a.m. Microarray Approaches in Cancer Prevention Jackie
Lavigne, PhD, MPH

9:30-10:30 The Interactome André Valente, PhD

Break

11:00 a.m. - 12:30 p.m. The Integration of Molecular Markers Into
Nathaniel Rothman, MD

> Population Studies I

Lunch

1:30 p.m. - 3:00 p.m. Molecular Epidemiology: The Integration of\`
Nathaniel Rothman, MD

> Molecular Markers Into Population Studies II
>
> Faculty

Carl Barrett, PhD -- *Cancer From a Biosystem Perspective*

> Director, Novartis Institutes for Biomedical Research, 250
> Massachusetts Ave., Suite 3A-203, Cambridge, MA 02139; 617-871-3700;
> carl.barrett@novartis.com

**Michael Birrer, MD, PhD** **--** *Oncogenes, Tumor Suppressor Genes,
and Other Cancer-Related Genes*

> Senior Investigator, Cell and Cancer Biology Branch, Head, Molecular
> Mechanisms Section, Center for Cancer Research, NCI, NIH, Building 37,
> Room 1130, 37 Convent Drive, Bethesda, MD 20892; 301-402-3128, ext.
> 311; [**birrerm@bprb.nci.nih.gov**](mailto:birrerm@bprb.nci.nih.gov)

**Peter L. Choyke, MD** --- *New Approaches to Imaging Cancer Processes
In Vivo*

Senior Clinician, Molecular Imaging Program, Center for Cancer Research,
NCI, NIH, Building 10, Room 1B40, 9000 Rockville Pike, Bethesda, MD
20892-1088; 301-451-4221; pchoyke@nih.gov

Jeffrey Green, MD -- *Animal Models for Cancer Prevention Studies*

> Senior Investigator, Laboratory of Cell Regulation and Carcinogenesis,
> Head, Transgenic Oncogenesis Group, Center for Cancer Research, NCI,
> NIH, Building 41, Room C619, 41 Library Drive, Bethesda, MD 20892;
> 301-435-5193; [**jg155c@nih.gov**](mailto:jg155c@nih.gov)

**John Greiner, PhD** -- *The Immune System as a Target for Vaccine*
*and Prevention Approaches*

> Section Chief, Laboratory of Tumor Immunology and Biology, Center for
> Cancer Research, NCI, NIH, Building 10, Room 8B04, 10 Center Drive,
> Bethesda, MD 20892-1750; 301-496-9813;
> [**greinerj@mail.nih.gov**](mailto:greinerj@mail.nih.gov)

**Curtis Harris, PhD** --- *The Role of Inflammation in Cancer*

> Laboratory Chief, Laboratory of Human Carcinogenesis, Head, Molecular
> Genetics and Carcinogenesis Section, Center for Cancer Research, NCI,
> NIH, Building 37, Room 3068A, Bethesda, MD 20892; 301-496-2048;
> curtis_harris@nih.gov

**Norman Hord, PhD, MPH, RD** --- *Overview of Carcinogenesis*

Assistant Professor, Department of Food Science and Human Nutrition,
Michigan State University,

208C Trout Food Science and Human Nutrition Building, East Lansing, MI
48824; 517-355-7713 x186; hord@msu.edu

Thomas Kensler, PhD -- *Xenobiotic Metabolism and Cancer Susceptibility*

> Professor, Department of Environmental Health Sciences, Division of
> Toxicology, The Johns Hopkins University Bloomberg School of Public
> Health, 615 N. Wolfe Street, Rm. E 7541, Baltimore, MD 21205;
> 410-955-4712; [**tkensler@jhsph.edu**](mailto:tkensler@jhsph.edu)

**Jackie A. Lavigne, PhD, MPH** --- *Introduction/Course Overview and
Molecular Biology Primer*

and *Microarray Approaches in Cancer Prevention*

Associate Director, Cancer Prevention Fellowship Program, Office of
Preventive Oncology, NCI, NIH, Executive Plaza North, Room 321, MSC
7361, 6130 Executive Boulevard, Bethesda, MD 20892-7361; 301-496-8640;
lavignej@mail.nih.gov

**Nathaniel Rothman, MD, MPH, MHS** -- *The Integration of Molecular
Markers Into Population Studies I*

######### and Molecular Epidemiology: The Integration of Molecular Markers Into 

> *Population Studies* II
>
> Senior Investigator, Occupational Epidemiology Branch, Division of
> Cancer Epidemiology and Genetics, National Cancer Institute, National
> Institutes of Health, Executive Plaza South, Room 8116, 6120 Executive
> Boulevard, Bethesda, MD 20892; 301-496-9093;
> [**rothmann@mail.nih.gov**](mailto:rothmann@mail.nih.gov)

**Patricia S. Steeg, PhD** -- *The Quest for New Molecular Targets for
Cancer Prevention and Treatment*

> Senior Investigator, Laboratory of Molecular Pharmacology, Head,
> Women's Cancers Section, Center for Cancer Research, NCI, NIH,
> Building 37, Room 1-122, 37 Convent Drive, Bethesda, MD 20892;
> 301-402-2732; [**steegp@mail.nih.gov**](mailto:steegp@mail.nih.gov)

**André Valente, PhD** --- *Analyzing Complex Data Sets*

Visiting Fellow, Division of Cancer Prevention, NCI, NIH, Executive
Plaza North, Suite 3131, 6130 Executive Boulevard, Bethesda, MD
20892-7354; 301-496-8550; andre@deas.harvard.edu

**John Weinstein, MD, PhD** --- *Application of Genomics and Proteomics
to Cancer Research*

Senior Investigator, Laboratory of Molecular Pharmacology, Head, Gene
Expression Profiling and Bioinformatics Group, Center for Cancer
Research, NCI, NIH, Building 37, Room 5068, Bethesda, MD 20892;
301-496-0651; weinstein@dtpax2.ncifcrf.gov

**Karen Woodson, PhD, MPH** --- *Methylation as a Target for
Chemoprevention*

Investigator, Genetics Branch, Center for Cancer Research, NCI, NIH,
6116 Executive Blvd., Suite 705, Bethesda, MD 20892; 301-496-0651;
woodsonk@mail.nih.gov

**James D. Yager, PhD**--- *Hormonal Carcinogenesis*

Professor, Division of Toxicology, Department of Environmental Health
Sciences; Senior Associate Dean of Academic Affairs, Johns Hopkins
Bloomberg School of Public Health, 615 N. Wolfe St., Room W1025,
Baltimore, MD 21205; 410-955-3348; jyager@jhsph.edu