# Resume

(Updated on 02/28/2004)

## Evgeni Selkov

### Present Address

> 1409 Heatherton Dr.
>
> Naperville, IL 60563-2232
>
> Phone: 1-630-357-5881
>
> Fax: 1-630-729-3161
>
> Mobile: 1-773-343-6172
>
> Email: <evgeni@wowway.com>, <evgeni@mcs.anl.gov>

### **Education**

1981 - Granted rank of Professor of Biophysics from the Russian Academy
of Sciences

1980 - Defended doctoral (D.Sc.) thesis on \`\`Kinetics of open
multienzyme systems\'\'. Granted with the Doctor of
Physical-Mathematical Sciences Degree from the Russian Academy of
Sciences

1972 - Defended candidate (Ph.D.) thesis on \`\`Mathematical simulation
of single-frequency glycolytic oscillations\'\'. Granted with the
Candidate of Physical-Mathematical Sciences Degree (Ph.D) from the
Russian Academy of Sciences

1967 - Graduated Electronics Engineer, specialization Engineer of
Audiotechnics, from the St. Petersburg Institute of Cinema Engineers.

### **Employment History**

Senior Fellow, Computational Institute, Argonne National Laboratory and
University of Chicago, Illinois, 2003 -- present

Senior Scientist, Mathematics and Computer Science Division, Argonne
National Laboratory, Argonne, Illinois, 2001 \-- present

Computational Biologist, Mathematics and Computer Science Division,
Argonne National Laboratory, Argonne, Illinois, 2001

Vice President, Director of Metabolic Design Division, Integrated
Genomics, Inc., Chicago, 1999 \-- 2001

President, EMP Project, Inc., New York, 1999\--2000

Computational Biologist, Mathematics and Computer Science Division,
Argonne National Laboratory, Argonne, Illinois, 1997\--2000

Consultant of European Molecular Biology Laboratory (EMBL), European
Bioinformatics Institute (EBI), Hinxton, UK, 1996-1997

Adjunct Professor, Institute for Biosciences, Bioinformatics, and
Biotechnology, Fairfax, VA, 1996-1997

Visiting Scientist, Mathematics and Computer Science Division, Argonne
National Laboratory, Argonne, Illinois, 1994---1997

Head of the Laboratory of Mathematical Simulation of Multienzyme Systems
of the Institute of Theoretical and Experimental Biophysics of the
Russia Academy of Sciences at the Pushchino Biological Research Center,
Pushchino, Russia, 1991\--2001

Professor, Physicochemical Biology, Biological Faculty, Moscow State
University, Pushchino, 1989\--1995

Head, Laboratory of Mathematical Simulation of Multienzyme Systems,
Institute of Biological Physics, USSR Academy of Sciences, Pushchino
Biological Research Center, Pushchino, Russia, 1972\--1991

Junior Research Fellow, Institute of Biological Physics, USSR Academy of
Sciences, Pushchino Biological Research Center, Pushchino, Russia,
1964\--1972

Leading Engineer in Electronics and Leader of Research Group on Cellular
Biophysics, Institute of Cybernetics, Ukraine Academy of Sciences, Kiev,
Ukraine, 1961\--1964

Senior Engineer of Electronics, Institute of Physiology, St. Petersburg
State University, 1961

Senior Engineer of Electronics, Institute of Evolutionary Physiology,
USSR Academy of Sciences, 1959\--1960

Senior Technical Assistant in Electronics, St. Petersburg Institute of
Cinema Engineers, 1957\--1958

### **Teaching Experience**

### 

Adjunct Professor, Institute for Biosciences, Bioinformatics, and
Biotechnology, Fairfax, VA, 1996\--1997

Professor, Physicochemical Biology, Biological Faculty, Moscow State
University, Pushchino, 1989\--1995

Senior Lecturer, Physicochemical Biology, Biological Faculty, Moscow
State University, Pushchino, 1972\--1989

Senior Lecturer, Moscow Physicotechnical Institute, 1969\--1972

Senior Lecturer, Physics Faculty, Moscow State University, 1968\--1969

Supervisor of the following PhD student works:

1.  V. G. Nazarenko, Theoretical analysis of infra-low frequency
    oscillations in cell populations, Institute of Biological physics,
    Academy of Sciences of the USSR, Pushchino, 1976

2.  V. D. Dynnik, Theoretical study of the glycolytic oscillation
    mechanisms, Institute of Biological physics, Academy of Sciences of
    the USSR, Pushchino, 1977

3.  N. P. Kaimachnikov, Theoretical study of the open enzyme reaction
    dynamics, Institute of Biological physics, Academy of Sciences of
    the USSR, Pushchino, 1979

4.  S. P. Popova, Analysis of the kinetics and regulatory functions of
    oligomeric enzymes, Institute of Biological physics, Academy of
    Sciences of the USSR, Pushchino, 1980

5.  N. I. Markevich, Analysis of the kinetics of the ion transport via
    controlled ion channels. Institute of Biological physics, Academy of
    Sciences of the USSR, Pushchino, 1982

6.  A. P. Saveliev, The dependence of zonation rhythm of a Streptomycete
    on space flight factors, Institute of Biological physics, Academy of
    Sciences of the USSR, Pushchino, 1983

7.  E. L. Shevelev, Mathematical simulation of the kinetics of cyclic
    enzyme systems. Institute of Biological physics, the Russian Academy
    of Sciences, Pushchino, 1992

8.  I. I. Goryanin, Automation of mathematical modeling polyenzyme
    systems based on a database of enzymes and metabolic pathways.
    Institute of Biological physics, Russian Academy of Sciences,
    Pushchino, 1995

9.  A. M. Taranenko, Futile cycles and the deposition effect. Institute
    of Biological physics, Russian Academy of Sciences, Pushchino, 1996

The above PhD theses have been granted with PhD degrees for
physical-mathematical sciences, except the A. P. Saveliev who has been
granted with the degree for biological sciences.

## Professional Activities

### 

### **Journal Editorial Boards**

Member of the Editorial Board, Bioprocess and Biosystems Engineering,
Springer-Verlag, Heidelberg, 2000\-- Present

Member of the Editorial Board, Bulletin du Groupe d\'etude des rhythmes
biologiques, 1972---1995, Clermon-Ferran, France, 1972\--1995

Member, Advisory Board, International Journal of Chronobiology, Gordon
and Breach, Science Publishers, New York, 1973---1983

Besides, some biological journals (Bioinformatics, BioSystems, Eur. J.
Biochem., J. Theor. Biol., Biofisika (Moscow), Biokhimiya (Moscow),
Molekularnaya biologiaya (Moscow)) and funding agencies (NIH, USDA) ask
me irregularly to review and evaluate submitted manuscripts or grant
proposals.

### **Membership in Professional Societies**

Member, Federation of American Societies of Experimental Biology, FASEB,
since 1999

Member, American Association for the Advancement of Science, AAAS, since
1998

Member, American Chemical Society, ACS, since 1998

Member, American Society for Microbiology, ASM, since 1998

Leader, Working Group on Creation of Biological Databases on Enzymes and
Metabolic Pathways, National Committee of CODATA, Moscow, 1986\--1995

Member, Russian National Committee of CODATA, Moscow, 1986\--1995

Corresponding member, CODATA Working Group on Biological Macromolecules,
Paris, 1988\--1989

Corresponding Member, Groupe d\'etude des rhythmes biologiques,
1972\--1995

Member, Russian Biophysical Society, since 1972

Member, Russian Biochemical Society, since 1968

## Main Scientific Results

Theoretical prediction of the existence of trigger phenomena in open
biochemical reactions with substrate inhibition, 1966

Theoretical analysis of existence of oscillations in a wide range of
open biochemical reaction systems with feedback, 1967

Formulation of a theory of the glycolytic oscillations as the limit
cycle phenomenon, 1968

Formulation of a theory of the cell clock and cell cycle as the limit
cycle phenomena, 1970

Discovery of the deposition effect, 1971

Prediction that essential nonlinearities in the cell metabolism can be
targets for tight stabilizing control, 1972

Demonstration of the dynamical equivalence of a wide class of the
oscillatory and trigger biochemical systems, 1972

Theory of hierarchical organization of metabolic pathways, 1973

Theoretical and experimental proof that the glycolytic stoichiometric
structure is capable of stiffly stabilizing the adenylate Atkinson
charge without any allosteric regulatory mechanisms, 1973

Theoretical proof that the energy wasteful substrate recycling in the
central futile cycles of the cell energy metabolism can be effectively
suppressed by a self-oscillatory organization only, 1976

Derivation of a generalized Monod-Wyman-Changeux model for the case of a
multisubstrate reaction, 1976

Discovery of the resonance and parametric resonance phenomena in simple
open enzymatic reactions and in excitable membranes, 1980.

Creation of the database on enzymes and metabolic pathways, DBEMP
(currently known as EMP) 1983\--

Quantitative theory of the very stable circadian cell clock based on the
temporal organization of the cell energy metabolism and the deposition
effect, 1987

Discovery of the deposition effect without reactions of fast deposition,
1991

Development of the metabolic and functional reconstruction technology
from sequenced genomes, 1993-2001

Metabolic and functional reconstruction from publicly available genomes,
1994-2001

## Publications

### Books

1.  Sel\'kov, E. E., ed., Oscillatory Processes in Biological and
    Chemical Systems, Transactions of All-Union Symposium. Vol. 2.,
    Pushchino, **1971**, pp.362 (in Russian)

2.  Ivanitsky, G. R., Krinsky, V. I., and Sel\'kov, E. E., Mathematical
    Biophysics of the Cell, Nauka Publishers, Moscow, **1978**, pp. 310
    (in Russian)

3.  Reich, J. G., and Sel\'kov, E. E. Energy Metabolism of the Cell. A
    Theoretical Treatise, Academic Press, London, **1981**, pp. 345

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4.  Selkov, E. E., EMP User Manual. A Guide to the Enzymes and Metabolic
    Pathways Database, Release 1.0. Superior Printing, Champaign,
    Illinois, **1995**, pp. 2000

### Journal Articles and Book Chapters

1.  Sel\'kov E. E. \-- Adaptive properties of enzyme reactions with
    enzyme-forming system. In: Simulation in Biology and Medicine.
    (N. M. Amosov, ed.), Kiev, Naukova Dumka Publishers, **1965**, pp.
    106-116 (In Russian)

2.  Sel\'kov E. E. \-- Polyenzyme system of the cell as an object of
    bionics studies. In: Bionika. Nauka Publishers, Moscow, **1965**,
    pp. 173-179 (In Russian)

3.  Sel\'kov E. E. \-- Hysteretic transitions in enzymatic reactions
    with substrate inhibition. Steady state kinetics. In: Some
    Biocybernetics Problems. Application of Electronics to Biology and
    Medicine. (N. M. Amosov, ed.), Vol. 1, Kiev, Naukova Dumka
    Publishers, **1966**, pp. 81-101 (In Russian)

4.  Sel\'kov E. E., Filanovskaya A. N., Demchenko L. I. \-- Contribution
    to the issue of kinetic induction. . In: Simulation in Biology and
    Medicine. (N. M. Amosov, ed.), Vol. 2, Kiev, Naukova Dumka
    Publishers, **1966**, pp. 126-141 (In Russian)

5.  Sel\'kov E. -- On the possibility of matrix method analysis for
    studying steady state kinetics of enzyme reactions. In: Simulation
    in Biology and Medicine. (N. M. Amosov, ed.), Vol. 2, Kiev, Naukova
    Dumka Publishers, **1966**, pp. 118-125 (In Russian)

6.  Sel\'kov E. -- Self-oscillatory biochemical systems. Kinetic and
    mathematical models. In: Bionics. Simulation of Biological Systems.
    Naukova Dumka Publishers. Kiev, **1967**, pp. 99-121 (In Russian)

7.  Sel'kov E. -- Amplification properties of enzymatic reactions. In:
    Bionics. Simulation of Biological Systems. Naukova Dumka Publishers.
    Kiev, **1967**, pp. 146-150 (In Russian)

8.  Sel'kov E. -- On the mechanism of single-frequency self-oscillations
    in glycolysis. I. A simple kinetic model. Eur. J. Biochem.,
    **1968**, 4(1), 79-86

9.  Sel'kov E. E. -- Self-oscillations in glycolysis. A simple
    single-frequency model. Molekularnaya biologiya, **1968**, 2(2),
    252-256 (in Russian)

10. Sel'kov Ye. Ye. -- Self-oscillations in glycolysis. A simple
    single-frequency model. Molecular biology (New York), **1968**,
    2(2), 263-267

11. Betz A., Sel'kov E. -- Control of phosphofructokinase \[PFK\]
    activity in conditions simulating those of glycolysing yeast
    extract. FEBS Lett., **1969**, 3(10), 5-9

12. Deshcherevski V. I., Zhabotinsky A. M., Sel\'kov E. E., Sidorenko N.
    P., Shnol\' S. E. -- Oscillatory biological processes on the
    molecular level. Biofizika, **1970**, 15(2), 225-234 (in Russian)

13. Deshcherevski V. I., Zhabotinsky A. M., Sel\'kov Ye. Ye.,
    Sidorenko N. P., Shnol\' S. E. -- Oscillatory biological processes
    on the molecular level. Biophysics (New York), **1970**, 15(2),
    235-245

14. Sel'kov E. E., Sozinov L. A. -- Stabile circadian clocks as a
    property of cell populations. Life Sciences and Space Research,
    North-Holland, Amsterdam, **1970**, pp. 160-170

15. Sel'kov E. E. -- Two alternative oscillatory stationary states in
    the thiol metabolism -- two alternative modes of cell proliferation:
    normal and malignant one. Biofizika, **1970**, 15(6), 1065-1073 (in
    Russian)

16. Sel'kov Ye. Ye. -- Two alternative auto-oscillatory steady states in
    the metabolism of the thiols -- two alternative types of cell
    multiplication: normal and malignant. Biophysics (New York),
    **1970**, 15(6), 1104-1112

17. Sel'kov E. E. -- A study of the glycolytic oscillation mechanism. A
    relaxation oscillation model. In: Mathematical models of biological
    systems. (G. M. Frank, Ed.). Nauka Publishers, Moscow, **1971**, pp.
    5-24 (in Russian)

18. Samoilenko V. A., Sel'kov E. E. -- On the possibility of
    self-oscillations and several alternative steady states in an enzyme
    reaction with substrate and product inhibition. Biofizika, **1972**,
    17(5), 862-868 (in Russian)

19. Sel\'kov E.E. Nonlinearity of multienzyme systems, In: Analysis and
    Simulation of Biochemical Systems. H.C.Hemker, B.Hess (Eds).
    North-Holland, Amsterdam, **1972**, pp. 145-161

20. Sel'kov E. E. -- Nonlinear theory of regulation of the key step of
    glycolysis. Stud. Biophys., **1972**, 33(3), 167-176

21. Dynnik V. V., Sel'kov E. E. -- On the possibility of
    self-oscillations in the lower part of the glycolytic system. FEBS
    Letters, **1973**, 37(2), 342-346

22. Dynnik V. V., Sel'kov E. E., Semashko L. R. -- Analysis of the
    adenine nucleotide effect on the oscillatory mechanism in
    glycolysis. Stud. Biophys., **1973**, 41(3), 193-214

23. Selkov E. E., Nazarenko V. G. \-- Self-oscillatory states in cell
    population growth. In: Mathematical Simulation of Microbiological
    Processes. Nauka Publishers, Pushchino, **1973**, pp. 113-126 (in
    Russian)

24. Sel\'kov E. E., Betz A. \-- On the mechanism of single-frequency
    glycolytic oscillations. In: Biological and Biochemical
    Oscillations, (B. Chance, B. Hess, and K. Pye, Eds.), N.Y., Acad.
    Press, **1973**, pp. 197-220

25. Dynnik V. V., Sel'kov E. E. \-- On the possibility of
    self-oscillations in the lower part of the glycolytic system. FEBS
    Letters, **1973**, 37(2), 342-346

26. Sel\'kov E. E. \-- Autoregulation in biological system. In:
    Bol\'shaya Meditsinskaya Entsiklopediya. Vol. 3. Sovetskaya
    Entsiclopediya. Moscow. **1973**, pp. 149-157 (in Russian)

27. Dynnik V. V., Sel\'kov E. E., Semashko L. R. \-- Analysis of the
    adenine nucleotide effect on the oscillatory mechanism in
    glycolysis. Studia biophysica. **1974**, 41(3), 193-214

28. Reich J. G., Sel'kov E. E. -- Mathematical analysis of metabolic
    networks. FEBS Letters, **1974**, 40, Suppl., S119-S127

29. Popova S. V., Sel'kov E. E. -- Generation of the model by Monod,
    Wyman and Changeux for the case of reversible monosubstrate reaction
    S \<==\> P FEBS Letters, **1975**, 53(3), 269-273

30. Dynnik V. V., Sel'kov E. E. -- Oscillation generator in the lower
    part of the glycolytic system. Biofizika, **1975**, 20(2), 288-292

31. Dynnik V. V., Sel'kov Ye. Ye. -- Generator of oscillations in the
    lower part of the glycolytic system. Biophysics (New York),
    **1975**, 20(2), 292-297

32. Dynnik V. V., Sel'kov E. E. -- Double-frequency oscillations in the
    glycolytic system. Mathematical model. Biofizika, **1975**, 20(2),
    293-297 (in Russian)

33. Dynnik V. V., Sel'kov E. E., Ovchinnikov I. A. -- Impact of NAD
    recycling on the mechanism of ATP stabilization in cytoplasm.
    Mathematical models. Biokhimiya, **1975**, 20(2), 288-292 (in
    Russian)

34. Dynnik V. V., Sel'kov Ye. Ye. -- Double-frequency oscillations in
    the glycolytic system. Mathematical model. Biophysics (New York),
    **1975**, 20(2), 297-302

35. Glende M., Reich J. G., Drabsch H., Sel\'kov E. E. \-- Zur Stellung
    des Orthophosphates im Energiestoffwechsel der Zelle. Studia
    biophysica, **1975**, 52, 141-154

> 35\. Kaimachnikov N. P., Sel\'kov E. E. \-- Hysteresis and
> multiplicity of dynamic states in an open two-substrate enzymatic
> reaction with substrate inhibition. Biofizika, **1975**, 20(4),
> 703-708 (in Russian)
>
> 36\. Kaimachnikov N. P., Sel\'kov Ye. Ye. \-- Hysteresis and
> multiplicity of dynamic states in an open two-substrate enzymatic
> reaction with substrate repression. Biophysics (New York), **1975**,
> 20(4), 713-718
>
> 37\. Markevich N. I., Sel\'kov E. E. \-- Analysis of neuron population
> dynamics. In: Simulation of excitable structures. Pushchino, **1975**,
> pp. 42-60 (in Russian)
>
> 38\. Reich J. G., Sel'kov E. E. -- Time hierarchy, equilibrium and
> non-equilibrium in metabolic systems. BioSystems, **1975**, 7(1),
> 39-50
>
> 39\. Sel\'kov E. E. \-- Stabilization of energy charge, generation of
> oscillation and multiple steady states in energy metabolism as a
> result of purely stoichiometric regulation. Eur. J. Biochem.,
> **1975**, 59(1), 151-157
>
> 40\. Kaimachnikov N. P., Sel\'kov Ye. Ye. \-- Autocatalysis in the
> stoichiometric model of energy metabolism. Biophysics (New York),
> **1976**, 21(2), 217-222
>
> 41\. Kaimachnikov N. P., Sel\'kov E. E. \-- Autocatalysis in the
> stoichiometric model of energy metabolism. Biofizika, **1976**, 21(2),
> 220-224 (in Russian)
>
> 42\. Kaimachnikov N. P., Sel\'kov E. E. \-- An open enzymatic reaction
> S \<=\>P with substrate inhibition as the simplest biochemical
> oscillator. Biofizika, **1976**, 21(3), 428-433 (in Russian)
>
> 43\. Kaimachnikov N. P., Sel\'kov Ye. Ye. \-- Elementary biochemical
> autogenerator \-- open enzymatic reaction S \<=\>P with substrate
> depression. Biophysics (New York), **1976**, 21(3), 438-444
>
> 44\. Kaimachnikov N. P., Sel\'kov E. E. \-- Autocatalysis in a
> stoichiometric model of energy metabolism. Biofizika, **1976**, 21(3),
> 220-224 (in Russian)
>
> 45\. Kaimachnikov N. P., Sel\'kov E. E. \-- Elementary biochemical
> self-oscillator \-- an open enzymatic reaction S \<==\> P with
> substrate inhibition. Biofizika, **1976**, 21(3), 428-433 (in Russian)
>
> 46\. Popova S. V., Sel\'kov E. E. \-- Generalization of
> Monod-Wyman-Changeux model for the case of multisubstrate reaction.
> Molekularnaya biologiya, **1976**, 10(5), 1116-1126 (in Russian)
>
> 47\. Reich J. G., Sel\'kov E. E., Geier Th., Dronova V. \-- Dynamic
> properties of energy-regenerating pathways. Z-Shaped hysteresis of the
> load characteristics. Stud. Biophys., **1976**, 59(2), 117-138
>
> 48\. Popova S. V., Sel\'kov E. E. \-- Generalization of the
> Monod-Wyman-Changeux model to the case of a multisubstrate reaction.
> Molekularnaya Biologiya, **1976**, 10(5), 1116-1126 (in Russian)
>
> 49\. Popova S. V., Sel\'kov E. E. \-- Generalization of the
> Monod-Wyman-Changeux model to the case of a multisubstrate reaction.
> Molecular Biology (New York), **1976**, 10(5), 910-918
>
> 50\. Reich J. G., Sel\'kov E. E., Geier Th., Dronova V. \-- Elementary
> properties of energy-regenerating pathways. Studia biophysica,
> **1976**, 54, 57-76
>
> 51\. Reich J. G., Sel\'kov E. E., Geier Th., Dronova V. \-- Dynamic
> properties of energy-regenerating pathways. Z-Shaped hysteresis of the
> load characteristics. Studia biophysica, **1976**, 59, 117-138
>
> 52\. Reich J. G., Sel\'kov E. E., Glende M., Dronova V., Schulmeister
> Th. \-- On the compensatory effect of phosphate in the carbohydrate
> catabolism. Studia biophysica, **1976**, 60(1), 41-59
>
> 53\. Reich J. G., Sel\'kov E. E., Glende M., Dronova V. \--
> Alternative steady states of the carbohydrate metabolism (beak-shaped
> hysteresis). Studia biophysica, **1976**, 60, 205-222
>
> 54\. Sel\'kov E. E., Dynnik S. N. \-- Hysteresis, alternative steady
> states and auto-oscillations in an open futile cycle where one
> reaction is inhibited by its substrate. Biokhimiya, **1976**, 41(9),
> 1677-1683 (in Russian)
>
> 55\. Sel\'kov Ye. Ye., Dynnik S. N. \-- Hysteresis, multiplicity of
> steady states and auto-oscillations in the reversible flow reaction S1
> \<==\> S2 catalyzed by the oligomeric enzyme E(R, T). Biofizika,
> **1976**, 21(2), 214-219 (in Russian)
>
> 56\. Sel\'kov Ye. Ye., Dynnik S. N. \-- Hysteresis, multiplicity of
> steady states and auto-oscillations in the reversible flow reaction S1
> \<==\> S2 catalyzed by the oligomeric enzyme E(R, T). Biophysics (New
> York), **1976**, 21(2), 210-216
>
> 57\. Bohnensack R., Sel\'kov E. E. \-- Stoichiometric regulation in
> the citric acid cycle. I. Linear interactions of intermediates. Studia
> biophysica., **1977**, 65(3), 161-173
>
> 58\. Bohnensack R., Sel\'kov E. E. \-- Stoichiometric regulation in
> the citric acid cycle. II. Non-linear interactions. Studia
> biophysica., **1977**, 66(1), 47-63
>
> 59\. Bohnensack R., Sel\'kov E. E. \-- Stoichiometric regulation in
> the citric acid cycle. III. Non-linear autocatalysis by the glyoxalate
> shunt. Studia biophysica., **1977**, 66(2), 81-87
>
> 60\. Dynnik V. V., Sel\'kov E. E., Ovchinnikov I. A. \--
> Self-oscillations in the lower part of the glycolytic system. Two
> alternative mechanisms. Stud. Biophys., **1977**, 63(1), 9-23
>
> 61\. Dynnik V. V., Sel\'kov E. E., Ovchinnikov I. A. \-- Mathematical
> models for the mechanisms of double periodicities in glycolysis. Stud.
> Biophys., **1977**, 65(3), 183-204
>
> 62\. Dynnik V. V., Sel\'kov Ye. Ye., Ovchinnikov I. A. \-- Influence
> of NAD+ recycling on the ATP stabilization mechanism in cytoplasm.
> Biokhimiya (Engl. Trans.), **1977**, 42, 1223-1235
>
> 63\. Kaimachnikov N. P., Sel\'kov E. E. \-- Substrate inhibition as a
> case of oscillations in an open irreversible enzymatic reaction S1 +
> S2  S1\' + S2\'. Mathematical model. Biokhimiya, **1977**, 42(4),
> 639-646 (in Russian)
>
> 64\. Kaimachnikov N. P., Sel\'kov E. E. \-- Mathematical model of the
> adaptation of energy metabolism of the cell. Effect of ATP on the
> activity and concentration of the enzyme of the initial stage.
> Biofizika, **1977**, 22(2), 241-246 (in Russian)
>
> 65\. Kaimachnikov N. P., Sel\'kov Ye. Ye. \-- Mathematical model of
> the adaptation of energy metabolism of the cell. Effect of ATP on the
> activity and concentration of the enzyme of the initial stage.
> Biophysics (New York) **1977**, 22(2), 246-252
>
> 66\. Kaimachnikov N. P., Sel\'kov E. E. \-- Substrate inhibition as a
> case of oscillations in an open irreversible enzymatic reaction S1 +
> S2  S1\' + S2\'. A mathematical model. Biokhimiya, **1977**, 42(4),
> 639-646 (in Russian)
>
> 67\. Kaimachnikov N. P., Sel\'kov Ye. Ye. \-- Substrate inhibition as
> the case of oscillations in an open irreversible enzymatic reaction
> S1 + S2  S1\' + S2\'. A mathematical model. Biochemistry (New York),
> **1977**, 42(4), 490-495
>
> 68\. Schulmeister Th., Sel\'kov E. E. \-- Dynamic properties of a
> generalized Lotka-model. Studia biophysica, **1977**, 65(2), 121-132
>
> 69\. Sel\'kov E. E. \-- Mathematical simulation of polyenzyme systems.
> In: Biophysics of complex systems and radiation disturbances. Nauka
> Publishers, Moscow, **1977**, 76-89 (in Russian)
>
> 70\. Nazarenko V. G., Sel\'kov E. E. \-- Self-oscillations as the most
> probable mode of existence of the density controlled cell populations.
> Int. J. Chronobiology, **1978**, 5, 345-367
>
> 71\. Popova S. V., Sel\'kov E. E. \-- Regulatory reversible enzymatic
> reactions. Theoretical analysis. Molekularnaya biologiya, **1978**,
> 12(5), 1138-1151 (in Russian)
>
> 72\. Popova S. V., Sel\'kov Ye. Ye. \-- Regulatory reversible
> enzymatic reactions. Theoretical analysis. Molecular biology (New
> York), **1978**, 12(5), 878-889
>
> 73\. Schulmeister Th., Sel\'kov E. E. \-- Folded limit cycles and
> quasi-stochastic self-oscillations in a third order of an open
> biochemical system. Studia biophysica, **1978**, 72(2), s. 111-112,
> Microfiche 1/24-37
>
> 74\. Sel\'kov E. E., Dynnik S. N. \-- Comparative theoretical analysis
> of the open-chain reaction S1 \<==\> S2 E(R,T), in which the
> oligomeric enzyme E(R,T) is isosterically or allosterically activated
> by the product S2. Molekularnaya biologiya, **1978**, 12(5), 1122-1138
> (in Russian)
>
> 75\. Sel\'kov Ye. Ye., Dynnik S. N. \-- Comparative theoretical
> analysis of the open reaction S1 \<==\> S2 E(R,T), in which the
> oligomeric enzyme E(R,T) is isosterically or allosterically activated
> by the product S2. Molecular biology (New York), **1978**, 12(5),
> 864-877
>
> 76\. Popova S. V., Sel\'kov Ye. Ye. \-- Description of the kinetics of
> the two-substrate reactions of the type S1 + S2 \<==\> S3 + S4 by a
> generalized Monod, Wyman, Changeux model. Molecular biology (New
> York), **1979**, 13(1), 96-104
>
> 77\. Popova S. V., Sel\'kov E. E. \-- Description of the kinetics of
> the two-substrate reactions S1 + S2 S \<==\> S3 + S4 by a generalized
> Monod, Wyman, Changeux model. Molekularnaya biologiya, **1979**,
> 13(1), 129-139 (in Russian)
>
> 78\. Sel\'kov E. E. \-- Oscillatory basis of cell energy metabolism.
> In: Pattern formation by dynamic systems and pattern recognition. (H.
> Haken, Ed.) Springer Series in Synergetics 5. Springer-Verlag, Berlin,
> **1979**, pp. 166-174
>
> 79\. Sel\'kov E. E. \-- Analysis of hierarchical organization of
> polyenzyme systems. In Methodology and theoretical problems of
> biophysics. Nauka Publishers, Moscow, **1979**, 140-161 (in Russian)
>
> 80\. Sel\'kov E. E., Avseenko N. V., Kirsta Yu. B. \-- Allosteric
> regulation in the open futile cycle fructose-6-P S \<==\>
> fructose-1,6-P2. Biofizika, **1979**, 24(5), 829-834 (in Russian)
>
> 81\. Sel\'kov E. E., Dynnik S. N., Kirsta Yu. B. \-- Qualitative
> investigation of a mathematical model of the open futile cycle
> fructose-6-P S \<==\> fructose-1,6-P2. Biofizika, **1979**, 24(3),
> 431-437 (in Russian)
>
> 82\. Sel\'kov Ye. Ye., Avseenko N. V., Kirsta Yu. B. \-- Allosteric
> regulation in the open futile cycle fructose-6-P S \<==\>
> fructose-1,6-P2. Biophysics (New York), **1979**, 24(5), 848-854
>
> 83\. Avseenko N. V., Sel\'kov E. E., \-- Analysis of the allosteric
> mechanisms for suppression of the parasitic recirculation in the
> futile fructose-6-P S \<==\> fructose-1,6-P2 cycle. Biofizika,
> **1980**, 25(4), 627-633 (in Russian)
>
> 84\. Boiteux A., Hess B., Sel'kov E. E. \-- Creative functions of
> instability and oscillations in metabolic systems. Curr. Top. Cell.
> Reg., **1980**, 17, 171-203
>
> 85\. Dvorak I., Sel\'kov E. E. \-- The stoichiometric and allosteric
> regulation in the Calvin cycle. Photosynthetica, **1980**, 14(4),
> 564-574
>
> 86\. Dynnik V. V., Heinrich R., Sel\'kov Ye. Ye. \-- A mathematical
> model of carbohydrate energy metabolism. Interaction glycolysis, the
> Krebs cycle, and the H-transporting shuttles at varying ATPase load.
> Biochemistry (New York), **1980**, 45(5), 589-598
>
> 87\. Dynnik V. V., Heinrich R., Sel\'kov E. E. \-- A mathematical
> model of carbohydrate energy metabolism. Interaction of glycolysis,
> the Krebs cycle, and the H-transporting shuttles at the varying ATPase
> load.. Biokhimiya, **1980**, 45(5), 771-782 (in Russian)
>
> 88\. Heinrich R., Dynnik V. V., Sel\'kov E. E. \-- A mathematical
> model for carbohydrate energy metabolism. The mechanism of the Pasteur
> effect. Biokhimiya, **1980**, 45(6), 963-972 (in Russian)
>
> 89\. Heinrich R., Dynnik V. V., Sel\'kov Ye. Ye. \-- A mathematical
> model for carbohydrate energy metabolism. The mechanism of the Pasteur
> effect. Biochemistry (New York), **1980**, 45(6), 731-738
>
> 90\. Malkova I. A., Popova S. V., Sel\'kov E. E. \-- Multiplicity of
> steady states and auto-oscillations in an open reaction catalyzed by
> phosphofructokinase from *E. coli.* A quantitative model. Biofizika,
> **1980**, 25(3), 503-507 (in Russian)
>
> 91\. Malkova I. A., Popova S. V., Sel\'kov Ye. Ye. \-- Multiplicity of
> steady states and auto-oscillations in the open reaction catalyzed by
> phosphofructokinase from *E. coli.* Quantitative model. Biophysics
> (New York), **1980**, 25(3), 520-525
>
> 92\. Sel\'kov E. E. \-- Instability and self-oscillations in the cell
> energy metabolism. Ber. Bunsenges. Phys. Chem., **1980**, 84, 399-402
>
> 93\. Sel\'kov E. E., Avseenko N. V. \-- Theoretical proof of the
> necessity to suppress parasitic cycling in the futile fructose-6-P
> \<==\> fructose-1,6-P2 cycle. Biofizika, **1980**, 25(2), 227-231 (in
> Russian)
>
> 94\. Sel\'kov Ye. Ye., Avseenko N. V. \-- Theoretical proof of the
> need to suppress parasitic recirculation in the futile fructose-6-P
> \<==\> fructose-1,6-P2 cycle. Biophysics (New York), **1980**, 25(2),
> 232-236
>
> 95\. Nazarenko V. G., Sel\'kov E. E. \-- Oscillations and resonance
> phenomena in a simple open enzymatic reaction  S  P  interacting
> with the enzyme-producing system. Biofizika, **1981**, 24(1), 17-21
> (in Russian)
>
> 96\. Nazarenko V. G., Sel\'kov E. E. \-- Self-oscillations in an open
> biochemical substrate-inhibited reaction interacting with the
> enzyme-producing system. Biofizika, **1981**, 24(3), 428-433 (in
> Russian)
>
> 97\. Jonnalagadda S. B., Becker J.-U., Sel\'kov E. E., Betz A. \--
> Flux regulation in glycogen-induced oscillatory glycolysis in
> cell-free extracts of *Saccharomyces carlsbergensis*. BioSystems,
> 1982, 15(1), 49-58

98. Ebeling W., Herzel H., Sel'kov E. E. The influence of noise on an
    oscillating glycolytic model. Stud. Biophys., **1983**, 98(3),
    147-154

99. Lazareva A. V., Evtodienko Yu. V., Sel\'kov E. E. \-- The effect of
    the intermediates of energy metabolism on adenylate cyclase
    activity. Stud. Biophys., **1983**, 96(2), 141-147

100. Markevich N. I., Sel'kov E. E. -- Resonance phenomena in the
     membranes having ionic channels with two conformational channels.
     Biofizika, **1983**, 28(2), 260-266 (in Russian)

> 101\. Myakishev A. S., Popova S. V., Selkov E. E. \-- Parameter
> estimation for pyruvate kinase reaction model from experimental data.
> Biofizika, **1983**, 28(3), 338-340 (in Russian)
>
> 102\. Nazarenko V. G., Sel\'kov E. E. \-- Kinetic resonance in open
> biochemical reaction with genetic induction of enzyme biosynthesis,
> Biofizika, **1983**,28(1), 30-34 (in Russian)
>
> 103\. Avseenko N. V., Sel'kov E. E. \-- Oscillations and trigger
> phenomena in the stoichiometric model of the of fatty acid metabolism.
> Biofizika, **1984**, 29(6), 940-944 (in Russian)
>
> 104\. Boiteux A., Hess B., Sel'kov E. E. -- Experimental and
> theoretical studies of the regulatory hierarchy in glycolysis. In:
> Self-Organization. Autowaves and Structures Far From Equilibrium. (V.
> I. Krinsky, Ed.) Springer Series in Synergetics 28. Springer, Berlin,
> **1984**, pp. 240-251
>
> 105\. Markevich N. I., Sel'kov E. E. -- Resonance phenomena in the
> membranes with the inactivation channels. Biofizika, **1984**, 29(5),
> 816-821 (in Russian)
>
> 106\. Nazarenko V. G., Sel'kov E. E. \-- Kinetic resonance in an open
> biochemical reaction catalyzed by an enzyme with two forms of
> different activity. Biofizika, **1984**, 29(4), 574-577 (in Russian)
>
> 107\. Ivanitskaya Yu. G., Sel'kov E. E. -- Peculiarity of the
> stoichiometric regulation of glycolysis in prokaryotic cells.
> Mathematical simulation. Biofizika, **1985**, 30(6), 1016-1021 (in
> Russian)
>
> 108\. Markevich N. I., Sel'kov E. E. -- Parametric resonance and
> periodic perturbation amplification in the membranes with the
> inactivation channels. Biofizika, **1985**, 30(5), 853-857 (in
> Russian)
>
> 109\. Markevich N. I., Sel'kov E. E. -- A mathematical model of
> resonance amplification on external effects on membranes. Biofizika,
> **1986**, 31(4), 662-666 (in Russian)
>
> 110\. Sel'kov E. E., Goryanin I. I. -- A nearly ideal biochemical
> relaxation oscillator based on an enzyme covalent modification.
> Molekularnaya biologiya, **1986**, 20(6), 1550-1561 (in Russian)
>
> 111\. Avseenko N. V., Lisnichuk L. Ya., Sel'kov E. E. -- A
> mathematical model of circadian rhythm stabilization in the cell
> energetic metabolism. Biofizika, **1987**, 32(2), 248-252 (in Russian)
>
> 112\. Ebeling W., Herzel H., Sel'kov E. E. Theory of stochastic
> biochemical oscillations. Transactions of 16th Conference on
> Non-Linear Oscillations. Moscow, **1987**, Vol. 2., pp. 432-435
>
> 113\. Sel'kov E. E., Shevelev E. L. -- Oscillations and trigger
> phenomena in fructose-2,6-bisphosphate metabolism. A mathematical
> model. Biofizika, **1987**, 32(2), 242-247 (in Russian)
>
> 114\. Shevelev E. L., Sel\'kov E. E. -- The key role of
> fructose-2,6-bisphosphate in the temporal organization of carbohydrate
> metabolism. An auto-oscillating mathematical model. Biofizika,
> **1987**, 32(3), 429-433 (in Russian)
>
> 115\. Shevelev E. L., Sel'kov E. E. \-- Concentration hierarchy in the
> mathematical model of fructose-2,6-bisphosphate exchange. Molecular
> biology, **1988**, 22(2), 459-465
>
> 116\. Shevelev E. L., Sel'kov E. E. \-- On a possibility of
> self-oscillations in the bacterial amino acid metabolism. A
> mathematical model. Biofizika, **1988**, 22(2), 459-465 (in Russian)
>
> 117\. Avseenko N. V., Goryanin I. I., Sel'kov E. E. \-- Circadian
> oscillations in a generalized model of the cell carbohydrate
> metabolism. Biofizika, **1989**, 34(5), 792-796 (in Russian)
>
> 118\. Markevich N. I., Sel\'kov E. E. -- Parametric resonance and
> amplification in excitable membranes. The Hodgkin-Huxley model. J.
> Theor. Biol., **1989**, 140(1), 27-38
>
> 119\. Sel\'kov E. E., Lisnichuk L. Ya., Avseenko N. V. -- A
> homeostasis of autooscillation period in a model of circadian cell
> clock. Biofizika, **1989**, 34(3), 459-463 (in Russian)
>
> 120\. Sel\'kov E. E., Goryanin I. I., Kaimachnikov N. P., Shevelev E.
> L., Yunus I. A. -- Factographic data bank on enzymes and metabolic
> pathways. Studia Biophys. **1989**, 129(2-3), 155-164
>
> 121\. Chuulun T., Sel\'kov E. E. \-- Self-oscillations and resonance
> phenomena in an open two-step enzyme system. Biofizika, **1990**,
> 35(2), 228-230 (in Russian)
>
> 122\. Cel\'kov E. E., Chuulun T., Battogtoh. D., \-- Multiresonance
> phenomena in an open multienzyme system. Stud. biophys, **1990**,
> 136(1), 103-107
>
> 123\. Markevich N. I., Sel\'kov E. E. -- Theoretical analysis of the
> oscillations in the membrane potential in the characean algae. Stud.
> Biophys. **1990**, 138(1-2), 147-156
>
> 124\. Potselueva M. M., Rotaru V. K., Evtodienko Yu. V., Sel\'kov E.
> E. \-- Periodic changes in the glycogen content along *Physarum
> polycephalum* cell cycle. Biologitcheskie Nauki, **1990**, 1990(12),
> 121-126 (in Russian)
>
> 125\. Taranenko A. M., Sel\'kov E. E. \-- Comparative study of the
> exchange mechanisms for storage compounds in the cell clock.
> Biofizika, **1990**, 35(4), 642-647
>
> 126\. Sel\'kov E. E., Taranenko A. M., The deposition effect without
> depot. Biofizika, **1991**, 36(5), 850-854 (in Russian)
>
> 127\. Goryanin I. I., Sel\'kov E. E., Serdyuk K. I. -- A refined
> mathematical model on a nearly ideal biochemical relaxation
> oscillation model based on an enzyme covalent modification.
> Molekularnaya biologiya, **1992**, 26(2), 404-417 (in Russian)
>
> 128\. Sel\'kov E. E., Stupnitchenko Yu. V. -- An information
> technology for creating metabolic pathways database. Biotekhnologiaya,
> **1993**, 1993(3), 35-39 (in Russian)
>
> 129\. Taranenko A. M., Sel\'kov E. E. -- Analysis of a cell clock
> model describing a suppression mechanism of the futile substrate
> cycling. Biofizika, **1994**, 39(3), 479-484 (in Russian)
>
> 130\. Taranenko A. M., Sel\'kov E. E. -- Analysis of a cell clock
> model describing a suppression mechanism of the futile substrate
> cycling. Biophysics (New York), **1994**, 39(3), 490-495 (in Russian)
>
> 131\. Gaasterland T., Selkov E. \-- Reconstruction of metabolic
> networks using incomplete information. ISMB, **1995**, 3, 127-135
>
> 132\. Selkov E., Basmanova S., Gaasterland T., Goryanin I., Grechkin
> Y., Maltsev N., Nenashev V., Overbeek R., Panyushkina E., Pronevich L,
> Sel\'kov E., Jr., Yunus I. \-- The metabolic pathway collection from
> EMP: the enzymes and metabolic pathways database. Nucleic Acids Res.
> **1996**, 24(1), 26-28
>
> 133\. Selkov E., Galimova M., Goryanin I., Gretchen Y., Ivanova N.,
> Komarov Y., Maltsev N., Mikhailova N., Nenashev V., Overbeek R.,
> Panyushkina E., Pronevich L., Sel\'kov E., Jr. \-- The metabolic
> pathway collection: an update. Nucleic Acids Res., **1997**, 25(1),
> 37-38

134. Taranenko A. M., Sel'kov E. E. \-- Highly effective suppression of
     futile substrate cycling by allosteric mechanisms in the model of
     the cell clock. Biofizika, **1997**, 42(2) 320-325 (in Russian)

135. 135\. Taranenko A. M., Sel'kov E. E. \-- Highly effective
     suppression of futile substrate cycling by allosteric mechanisms in
     the model of the cell clock. Biophysics (New York), **1997**, 42(2)
     330-335 (in Russian)

136. Overbeek R., Larsen N., Smith W., Maltsev N., Selkov E. --
     Representation of function: the next step. Gene, **1997**, 191(1),
     GC1-9

137. Selkov E., Maltsev N., Olsen G., Overbeek R., Whitman W. B. \-- A
     reconstruction of the metabolism of *Methanococcus jannaschii* from
     sequence data. Gene, **1997**, 197(1/2), GC10-25

138. Gillevet P. M., Ally A., Dolan M., Hsu E., Purzycki M. S., Overbeek
     R., Selkov E. E., Smith S., Wang C., Gilbert W. -- *Mycoplasma
     capricolum* genome project. In: Bacterial genomes: physical
     structure and analysis (de Bruijn F.J., Lupski J.R., Weinstock
     G.M., Editors), Chapman & Hall, New York, **1997**, pp. 526-540

139. Selkov E Jr, Grechkin Y, Mikhailova N, Selkov E. \-- MPW: the
     Metabolic Pathways Database. *Nucleic Acids Res* **1998** Jan 1
     **26:1** 43-45

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138. Overbeek R., Larsen N., Maltsev N., Push G.D., and Selkov E. \--
     Metabolic reconstruction systems. In: Bioinformatics: Databases and
     Systems (Stanley Letovsky, Ed.), Kluwer Academic Pub. **1999,** pp.
     37-45

139. Goryanin I, Hodgman T.C., Selkov E. Mathematical simulation and
     analysis of cellular metabolism and regulation. *Bioinformatics*
     **1999** Sep 15:9 749-758

140. Overbeek R, Larsen N, Pusch GD, D\'Souza M, Selkov E Jr, Kyrpides
     N, Fonstein M, Maltsev N, Selkov E. WIT: integrated system for
     high-throughput genome sequence analysis and metabolic
     reconstruction. *Nucleic Acids Res,* **2000,** 28(1) 123-125

141. Selkov E., Overbeek R., Kogan Y., Chu L., Vonstein V., Holmes D.,
     Silver S., Haselkorn R., Fonstein M. Functional analysis of gapped
     microbial genomes: amino acid metabolism of *Thiobacillus
     ferrooxidans*. *Proc Natl Acad Sci U S A* **2000** Mar 28 97:7
     3509-14

142. Covert M.W., Schilling C.H., Famili I., Edwards J.S., Goryanin
     I.I., Selkov E., Palsson B.O. Metabolic Modeling of Microbial
     Strains *in silico. TIBS*, **2001,** 26(3), 179-186

### Refereed Conference Proceedings

1.  Sel\'kov E. -- Electron transport and oxidative phosphorylation as
    variably coupled processes. II. A kinetic model. In: Mitochondria.
    Structure and Functions. Symposium Proceedings. Nauka Publishers,
    Moscow, **1966**, pp. 140-152 (In Russian)

2.  Sel'kov E. -- Analysis of the conditions for periodic oscillations
    in enzymatic systems with a feedback. In: Oscillatory Processes in
    Biological and Chemical Systems. Transactions of All-Union
    Symposium. Nauka Publishers, Moscow, **1967**, pp. 81-93 (In
    Russian)

3.  Sel'kov E. -- Oscillations in biochemical systems. Experimental
    data, hypotheses, models. In: Oscillatory Processes in Biological
    and Chemical Systems. Transactions of All-Union Symposium. Nauka
    Publishers, Moscow, **1967**, pp. 7-22 (In Russian)

> 4\. Sel'kov E. -- On the possibility of self-oscillations in enzyme
> reactions with substrate and product inhibition. In: Oscillatory
> Processes in Biological and Chemical Systems. Transactions of
> All-Union Symposium. Nauka Publishers, Moscow, **1967**, pp. 93-113
> (In Russian)
>
> 5\. Aponin Yu. M., Sel'kov E. E. -- On the oscillatory instability of
> the product repression mechanism of sub-unit enzyme synthesis
> mechanism. In: Oscillatory Processes in Biological and Chemical
> Systems. Transactions of All-Union Symposium. Vol. 2. (E. E. Sel'kov,
> Ed.), Pushchino, **1971**, pp. 80-83 (In Russian)
>
> 6\. Nazarenko V. G., Sel'kov E. E. -- Contact inhibition mechanism as
> a possible source of ultra low-frequency biological rhythms. In:
> Oscillatory Processes in Biological and Chemical Systems. Transactions
> of All-Union Symposium. Vol. 2. (E. E. Sel'kov, Ed.), Pushchino,
> **1971**, pp. 145-148 (In Russian)
>
> 7\. Samoilenko V. A., Sel'kov E. E. -- Self-oscillations and
> alternative steady states in an enzyme reaction with substrate and
> product inhibition. In: Oscillatory Processes in Biological and
> Chemical Systems. Transactions of All-Union Symposium. Vol. 2. (E. E.
> Sel'kov, Ed.), Pushchino, **1971**, pp. 50-53 (In Russian)

8.  Samoilenko V. A., Sel'kov E. E., Savchuk V. S. -- Analysis of the
    conditions for self-oscillations in an enzyme reaction with
    substrate and product inhibition. In: Oscillatory Processes in
    Biological and Chemical Systems. Transactions of All-Union
    Symposium. Vol. 2. (E. E. Sel'kov, Ed.), Pushchino, **1971**, pp.
    54-57 (In Russian)

9.  Sel'kov E. E. -- Cell clock as a self-oscillatory biochemical
    system. In: Oscillatory Processes in Biological and Chemical
    Systems. Transactions of All-Union Symposium. Vol. 2. (E. E.
    Sel'kov, Ed.), Pushchino, **1971**, pp. 5-10 (In Russian)

10. Sel\'kov E.E. Nonlinearity of multienzyme systems, In: Analysis and
    Simulation of Biochemical Systems. H.C.Hemker, B.Hess (Eds).
    North-Holland, Amsterdam, **1972**, pp. 145-161

11. Sel\'kov E. E. \-- Analysis of the temporal organization of
    multienzyme systems. IV International Biophysics Congress. Symposial
    papers. IUPAB and USSR Acad. Sci., Moscow, **1973**, pp. 437-475 (In
    Russian)

12. Sel\'kov E. E. -- Analysis of stoichiometric regulation of energy
    metabolism. In: Rapoport S, Jung F, Ed. Internationales Symposium
    uber Struktur und Funktion der Erythrozyten. Berlin,
    Akademie-Verlag, **1975**. W3 IN9848G 1973, pp. 17-19 (In Russian)

13. Dynnik V. V., Sel\'kov E. E. \-- Behavior of the glycolytic system
    and purine nucleotide metabolism under conditions of stress ATPase
    load. In: Regulation of Energy Exchange and Physiological State of
    Organism. (Kondrashova M. N. , Ed.) Nauka Publishers, Moscow,
    **1978**, pp. 51-66 (In Russian)

14. Dynnik V. V., Sel\'kov E. E. \-- Mathematical simulation of the
    mitochondrion-cytosol interactions under the load. In: Regulation of
    Energy Exchange and Physiological State of Organism.
    (Kondrashova M. N. , Ed.) Nauka Publishers, Moscow, **1978**, pp.
    51-66 (In Russian)

15. Sel\'kov E. E. \-- Temporal organization of energy metabolism and
    cell clock. In: Regulation of Energy Exchange and Physiological
    State of Organism. (Kondrashova M. N. , Ed.) Nauka Publishers,
    Moscow, **1978**, pp. 15-32 (In Russian)

16. W. Ebeling, H. Herzel, E. E. Selkov. \-- Theory of stochastic
    biochemical oscillations. In: *Proc. 16th FEBS-Congress Part C*. VNU
    Science Presss, **1985**, pp. 443-449

17. Markevich N. I., Sel\'kov E. E. -- A possible non-mechanical nature
    of the resonance sensitivity of biomembranes to periodic
    perturbations. In: Man under vibration. Proc. **1985**, pp. 77-82
    (In Russian)

18. Sel\'kov E. E. An evolution approach to the analysis of the cell
    energy metabolism. In: Methodology Problems of Theoretical Biology
    and Biophysics. Collection of Transactions of the Institute of
    Biological Physics, Academy of Sciences of the USSR, Pushchino,
    **1986**, pp. 124-128 (In Russian)

19. Sel\'kov E. E., Goryanin, I. I., Kaimachnikov, N. P., Shevelev, E.
    L., Yunus, I. A. \-- Factographic data bank on enzymes and metabolic
    pathways. In: \"Scientific and Technical Data in a New Era\" (P.S.
    Glaeser, ed.), Hemisphere Publishing Corp., **1990**, pp. 22-27

### Technical Reports

> 1\. Sel'kov E. -- Mathematical simulation of glycolytic oscillations.
> A relaxation model. Scientific Report N 68 008 265. Institute of
> Biological Physics. Pushchino, **1968**, pp. 1-120 (in Russian)
>
> 2\. Sel'kov E. E. -- A study of the glycolytic oscillation mechanism.
> Relaxation oscillation model. VINITI Publishers, 1256-69 Dep.,
> Pushchino, **1969**, pp. 1-39 (in Russian)
>
> 3\. Sel'kov E. E., Sozinov L. A. -- Stabile circadian clocks as a
> property of cell populations. VINITI Publishers 1230-69 Dep.,
> Pushchino, **1969**, pp. 1-22 (in Russian)
>
> 4\. Aponin Yu. M., Sel'kov E. E. -- Self-oscillations in the mechanism
> of product repression of a sub-unit enzyme synthesis. 3996-72 Dep.,
> VINITI 3996-72, Moscow, **1972**, pp. 1-13 (in Russian)
>
> 5\. Sel'kov E. E. -- Mathematical analysis of the mechanism of
> single-frequency oscillations of glycolytic intermediates. Thesis of
> Candidate Physical-Mathematical Sciences. Institute Biological
> Physics, U.S.S.R. Acad. Sci., Pushchino, **1972** (in Russian)
>
> 6\. Kaimachnikov N. P., Sel\'kov Ye. Ye. \-- Forms of the
> quasi-stationary characteristics, number of the stationary states and
> their stability in the open reversible one-substrate reaction
> catalyzed by an oligomeric enzyme. VINITI Publishers 167-78 Dep.,
> Moscow, **1978**, pp. 1-41 (in Russian)
>
> 7\. Dynnik V. V., Maevsky E. I., Sel\'kov E. E. \-- Determination of
> the most effective methods for controlling muscle energetics. VINITI
> Publishers N1960-79 Dep., **1979**, pp. 1-31 (in Russian)
>
> 8\. Sel\'kov E. E., Nazarenko V. G. \-- Kinetic induction of an
> enzyme, oscillations and resonance phenomena in a simple open
> enzymatic reaction  SP  interacting with the enzyme-producing
> system. VINITI Publishers 117-80 Dep., Moscow, **1979**, pp. 1-23 (in
> Russian)
>
> 9\. Sel\'kov E. E., Taranenko A. M., To the theory of cell clock: the
> storage of hexoses increases self-oscillation period in the futile
> cycle fructose-6-P \<==\> fructose-1,6-P2 by several orders of
> magnitude. VINITI Publishers 3622-79 Dep., Moscow, **1979**, pp. 1-17
> (in Russian)
>
> 10\. Sel\'kov E. E. \-- Kinetics of open polyenzyme systems. Thesis of
> Doctor Physical-Mathematical Sciences. Institute of Biological
> Physics. Pushchino, **1980**, pp. 1-213 (in Russian)
>
> 11\. Kaimachnikov N. P., Sel\'kov E. E. \-- On the mechanism of pulses
> and oscillations in cyclic nucleotides in *Dictyostelium discoideum*
> cells. VINITI Publishers 3669-81 Dep., Moscow, **1981**, pp. 1-22 (in
> Russian)
>
> 12\. Kaimachnikov N. P., Sel\'kov E. E. \-- Quantitative identity of
> two enzyme reaction models after parameter fitting of one of them.
> VINITI Publishers 3199-81 Dep., Moscow, **1981**, pp. 1-11 (in
> Russian)
>
> 13\. Sel'kov E. E., Shnoll E. E., Nikolaev E. V., Nazarenko V. G. \--
> Mathematical simulation of cell clocks self-synchronization in a
> non-growing cell population. VINITI Publishers, Pushchino, **1986**,
> pp. 1-67 (in Russian)
>
> 14\. Rotaru V. K., Kosenko E. A., Potselueva M. M., Sel'kov E. E. \--
> Periodic changes in the glycogen content in the *Physarum plycephalum*
> mitotic cycle. Institute of Biological Physics, Academy of Sciences of
> the U.S.S.R., Pushchino, **1988**, pp. 1-11 (in Russian)
>
> 15\. Sel\'kov E. E., Kaimachnikov N. P., Kozlovich L. I., E. L.
> Shevelev, I. A. Yunus. Data bank on enzymes and metabolic pathways.
> Issue 1. Description of a data bank format (23.02.88-version).
> Scientific Center of Biological Research of the Academy of Sciences of
> the USSR in Pushchino, **1988**, pp. 1-52 (in Russian)

### Other Publications

> 1\. Moskalenko Yu. E., Besov Yu. R., Petrov G. S., Sel\'kov E. E. \--
> A portative instrument for electropletismography. II All-Union
> Conference on Application of Electronics to Biology and Medicine.
> Abstracts of papers. VNIITEIR, Moscow, **1962**, p. 117 (in Russian)
>
> 2\. Sel\'kov E. E. \-- Polyenzyme system of the cell as an object of
> bionic studies. Conference on Bionics, Moscow 17-19 December.
> Abstracts of papers. Nauka Publishers, Moscow, **1963**, p. 20 (In
> Russian)
>
> 3\. Sel\'kov E. E., Demchenko L. I., Filanovskaya A. N. \-- Dynamics
> of enzymatic reactions with substrate inhibition. 6th Ukrainian
> Republic Conference on Physical Chemistry. Abstracts of papers.
> Naukova Dumka Publishers, Kiev, **1964**, pp. 126-128 (In Russian)
>
> 4\. Sel'kov E. E. -- On the mechanism of single-frequency
> self-oscillations in glycolysis. In: Abstracts of papers presented at
> the fifth FEBS Meeting. Prague, July 1968, **1968**, Abstr. 960
>
> 5\. Betz A., Sel'kov E. -- Control of phosphofructokinase activity
> under conditions simulating those of glycolysing yeast extract. In:
> Abstracts of papers presented at the sixth FEBS meeting. Madrid,
> **1969**, p. 212
>
> 6\. Betz A., Sel'kov E. -- A method for investigation of the adenylate
> controlled reactions. In: Abstracts of papers presented at the VI FEBS
> meeting. Madrid, **1969**, p. 211
>
> 7\. Sel'kov E. E., Sozinov L. A. -- Stabile circadian clocks as a
> property of cell populations. Abstracts of 12th COSPAR Meeting.
> Prague, **1969**, p. 160
>
> 8\. Aponin Yu. M., Sel'kov E. E. -- Impact of sub-unit association of
> a synthesized enzyme on the stability of the regulatory mechanism
> controlling its synthesis. In: Regulation in biological systems.
> Abstracts of papers. Pushchino, **1970**, pp. 38-40 (in Russian)
>
> 9\. Lunevskaya L. V., Sel\'kov E. E., Chaplain R. A. -- Mathematical
> model for ATPase reaction kinetics. In: Regulation in biological
> systems. Abstracts of papers. Pushchino, **1970**, pp. 17-19 (in
> Russian)
>
> 10\. Samoilenko V. A., Sel\'kov E. E. -- Mathematical analysis for the
> conditions of self-oscillations in a reaction with substrate and
> product inhibition. In: Regulation in biological systems. Abstracts of
> papers. Pushchino, **1970**, pp. 20-25 (in Russian)
>
> 11\. Sel'kov E. E., Sel'kova R. I., Semashko L. R. -- To the
> glycolytic oscillation theory. In: Regulation in biological systems.
> Abstracts of papers. Pushchino, **1970**, pp. 45-47 (in Russian)
>
> 12\. Sel'kov E. E. -- On the possibility of several steady states and
> self-oscillations in oxidative phosphorylation system. In: Regulation
> in biological systems. Abstracts of papers. Pushchino, **1970**, pp.
> 97-100 (in Russian)
>
> 13\. Sel'kov E. E., Nazarenko V. G. -- Analysis of the kinetics of
> cell population controlled by the contact inhibition mechanism. In:
> Regulation in biological systems. Abstracts of papers. Pushchino,
> **1970**, pp. 107-111 (in Russian)
>
> 14\. Baranov Yu. V., Sel'kov E. E. -- To the mechanism of relaxation
> oscillations in glycolysis. IV International Biophysics Congress.
> Abstracts of Papers Presented at Section 16-25. Moscow, **1972**,
> Abstr. EXVII 2A/7
>
> 15\. Dynnik V. V., Sel'kov E. E., Semashko L. R. -- Multiple
> alternative steady states of the key part of the glycolytic system. .
> IV International Biophysics Congress. Abstracts of Papers Presented at
> Section 16-25. Moscow, **1972**, Abstr. EXVII 2A/6
>
> 16\. Nazarenko V. G., Sel'kov E. E. -- Multiplicity of steady states
> and oscillations of the mitotic activity in cell populations. IV
> International Biophysics Congress. Abstracts of Papers Presented at
> Section 16-25. Moscow, **1972**, Abstr. EXVII 2B/8
>
> 17\. Sel'kov E. E. -- Analysis of the temporal organization of
> polyenzyme system. IV International Biophysics Congress. Abstracts of
> Papers Presented at Section 16-25. Moscow, **1972**, Abstr. SVII 2/3
>
> 18\. Sel\'kov E. E. \-- Nonlinearity of multienzyme systems. In:
> Analysis and Simulation of Biochemical Systems. Abstracts of papers
> presented at 8th FEBS Meeting. Amsterdam, August 1972, North-Holland,
> **1972**, Abstr. N 751
>
> 19\. Sel\'kov E. E. -- Analysis of stoichiometric regulation of energy
> metabolism. In: Abstracts of Papers Presented at Internationales
> Symposium uber Struktur und Funktion der Erythrozyten. Berlin,
> Akademie-Verlag, **1973**, pp. 4-8
>
> 20\. Sel\'kov E. E. \-- Analysis of the functional organization of
> multienzyme systems (MES). Abstracts of Papers Presented at IX FEBS
> Meeting, Budapest, August 1974, FEBS, Budapest, **1974**, Abstr. C3B3
>
> 21\. Sel\'kov E. E. \-- Regulation of polyenzyme systems. Abstracts of
> Papers Presented at the Third All-Union Biochemical Congress. Riga,
> **1974**, pp. 75-76 (in Russian)
>
> 22\. Kaimachnikov N. P., Sel\'kov E. E. \-- Mathematical model of an
> open enzyme reaction catalyzed by an oligomeric enzyme. In: Abstracts
> of papers presented at the first conference on mathematical theory of
> biological processes. Kaliningrad, **1976**, pp. 449-433 (in Russian)
>
> 23\. Markevich N. I., Rosanov S. I., Sel\'kov E. E. \-- A model of
> cytochemical mechanism of information storage in the nervous system.
> In: Abstracts of papers presented at the first conference on
> mathematical theory of biological processes. Kaliningrad, **1976**,
> pp. 402-404 (in Russian)
>
> 24\. Popova S. V., Sel\'kov E. E. \-- Generalization and analysis of
> Monod-Wyman-Changeux model. In: Abstracts of papers presented at the
> first conference on mathematical theory of biological processes.
> Kaliningrad, **1976**, pp. 462-463 (in Russian)
>
> 25\. Sel\'kov E. E. \-- Temporal organization of cell energy
> metabolism and cell clock. EMBO Workshop 1976 on Oscillatory Phenomena
> in Biological Systems. Dortmund, October 3-6, **1976**, p. 19
>
> 26\. Sel\'kov E. E. \-- A unifying theory of the cell clock mechanism.
> Chronobiologia, **1979**, 6(2), p. 34
>
> 27\. Markevich N. I., Sel\'kov E. E. \-- Resonance phenomena in
> biomembranes containing ion channels subjected to conformational
> transitions. In: All-Union Conference on Chronobiology and
> Chronopathology. Abstracts of papers. Moscow, **1981**, p. 162 (in
> Russian)
>
> 28\. Taranenko A. M., Sel\'kov E. E. \-- Impact of reserved compound
> pool on the cell clock. In: All-Union Conference on Chronobiology and
> Chronopathology. Abstracts of papers. Moscow, **1981**, p. 162 (in
> Russian)
>
> 29\. Markevich N. I., Sel\'kov E. E. \-- Theoretical study of the
> low-frequency electromagnetic field effect on biological membranes. I
> All-Union Biophysics Congress, Moscow August 1982. Abstracts of
> papers. Vol. 2, Moscow, **1982**, pp. 277 (in Russian)
>
> 30\. Nazarenko V. G., Sel\'kov E. E. \-- Kinetic resonance with
> respect to periodic perturbations in protein synthesis. I All-Union
> Biophysics Congress, Moscow August 1982. Abstracts of papers. Vol. 2,
> Moscow, **1982**, pp. 276-277 (in Russian)
>
> 31\. Sel\'kov E. E. \-- Current status of the cell clock theory. I
> All-Union Biophysics Congress, Moscow August 1982. Abstracts of
> papers. Vol. 2, Moscow, **1982**, pp. 28 (in Russian)
>
> 32\. Nazarenko V. G., Sel\'kov E. E. \-- Simple and parametric
> resonance in an open biochemical reaction catalyzed by an enzyme with
> active and inactive forms. In: Mechanisms of temporal organization of
> the cell and their regulation at different levels. Abstracts of
> papers. Pushchino, **1983**, p. 60 (in Russian)
>
> 33\. Saveliev A. P., Sel\'kov E. E. \-- Statistical analysis of the
> dependence of streptomycete zonation rhythm on space and geophysical
> factors. In: Mechanisms of temporal organization of the cell and their
> regulation at different levels. Abstracts of papers. Pushchino,
> **1983**, p. 19-21 (in Russian)
>
> 34\. Sel\'kov E. E. \-- Principles of temporal organization of the
> cell metabolism. In: Mechanisms of temporal organization of the cell
> and their regulation at different levels. Abstracts of papers.
> Pushchino, **1983**, p. 52 (in Russian)
>
> 35\. Sel\'kov E. E. \-- Dissipation against dissipation. Abstracts of
> papers of the 8th International Biophysics Congress, Bristol, **1984**
>
> 36\. Avseenko N. V., Lisnicuk L. Ja., Selkov E. E. \-- Die
> Stabilisation des Circadienen Rhythmus im Energiestoffwechsel.
> Numerische Analyse des Models. In: III DDR-UdSSR Symposium:
> Chronobologie und Chronomedizine. Kurzreferate. Halle, DDR, **1986**,
> s. 112 (in German)
>
> 37\. Gorjanin I. I., Selkov E. E. \-- Zur Theorie der
> Temperaturkompensation der Zelluhr. In: III DDR-UdSSR Symposium:
> Chronobologie und Chronomedizine. Kurzreferate. Halle, DDR, **1986**,
> s. 130 (in German)
>
> 38\. Selkov E. E. \-- Die Metabolische Theorie der Zellulaeren Uhr.
> In: III DDR-UdSSR Symposium: Chronobologie und Chronomedizine.
> Kurzreferate. Halle, DDR, **1986**, s. 34 (in German)
>
> 39\. Shevelev E. L., Selkov E. E. \-- Ein Neuer Molekularer
> Mechanismus der Zeitlichen Organisation des Kohlenhydratstoffwechsels.
> In: III DDR-UdSSR Symposium: Chronobologie und Chronomedizine.
> Kurzreferate. Halle, DDR, **1986**, s. 112 (in German)
>
> 40\. Sel\'kov E. E., Goryanin I. I., Kaimachnikov N. P., Shevelev E.
> L., Yunus E. A. \-- Data and knowledge banks on enzymes and metabolic
> pathways. In: Abstracts of 11th CODATA conference, **1988**, p. 3
>
> 41\. Gaasterland T., Maltsev N., Overbeek R., Selkov E. \-- The Role
> of Integrated Software and Databases in Genome Sequence Interpretation
> and Metabolic Reconstruction. In: Abstracts of Department of Energy
> Human Genome Program Contractor-Grantee Workshop V, Santa Fe, NM;
> January 28-February 1, **1996**
>
> 42\. Goryanin I, Galimova M., Overbeek R., Selkov E. \-- DBsolve: A
> Workbench for Mathematical Simulation of the Cellular Metabolism after
> Genome Sequencing. In: Abstracts of Department of Energy Human Genome
> Program Contractor-Grantee Workshop VI, Santa Fe, NM; January
> 28-February 1, **1996**
>
> 43\. Selkov E., Avseenko N., Basmanova S., Gillevet P., Goryanin I.,
> Grechkin Y. , Komarov, Yu. , Larsen N., Nenashev V., Overbeek R.,
> Panyushkina E., Pronevich L., Saveliev A., Selkov E., Jr., Shevelev
> E., Yunus I. \-- EMP: the Enzymes and Metabolic Pathways Database as a
> Unique Resource for Studying Ligand-Protein Interactions. The Second
> BioStandard Workshop, European Bioinformatics Institute, June **1996**
>
> 44\. Selkov E. -- Genome reconstruction: methodology, status, and
> outlook. A talk at Banbury Center Meeting "Integrating genetic,
> biochemical and other data in the post-genomics era," Cold Spring
> Harbor Laboratory, 6-9 April **1997**
>
> 45\. Selkov E., Overbeek R. -- The EMP effort, metabolic
> reconstruction, and metabolic regulation: exploitation of metabolic
> data in the interpretation of genomes. A talk at the 2nd Eur. Prot.
> Soc. Symp. 12-16 April 1997, Cambridge, England. Protein Science,
> **1997**, 6, Suppl. 1, p. 47

46. Selkov E., Overbeek R. -- Metabolic reconstruction from sequenced
    bacterial genomes: current status and outlook. A talk at the
    Institute Pasteur Euroconference "New targets for new antibiotics".
    Paris, June 4-6, **1997**

47. Goryanin I., Hodgman C., Lyall A., Selkov E. A poster presentation
    'Dbsolve: WWW software for metabolic simulations after genome
    sequencing' at ISMB-98, **1998**,

### Recent Invited Oral Presentations, 1997-2001

### I received many invitations to give a talk at scientific meetings of different levels. I could accept only a small portion of them, usually 3-4 invitations a year. The invitations listed below in *Italics* were not confirmed by me.

### 

1.  Invited talk 'Pathway databases' at the Pormal Symposium on
    Bioinformatics for the Post-Genome Sequencing Era, April 7,
    **1997**, GlaxoWellcome, Stevenage, UK

2.  Invited talk 'Metabolic Reconstruction: Status and Outlok at the
    Cold Spring Harbor Meeting on Integrating Genetic, Biochemical and
    Other Data in the Post-Genomic Era, 6-9 April **1997**, Banbury
    Center, Cold Spring Harbor Laboratory, NY

3.  Invited talk 'The EMP Effort, Metabolic Reconstruction, and
    Metabolic Regulation: Exploitation of Metabolic Data in the
    Interpretation of Genomes' at the Second European Symposium of on
    Bioinformatics and Protein Design of the Protein Society, FASEB,
    April 12-16, **1997**, Cambridge, UK

4.  Invited talk on 'Metabolic pathways' at the International Symposium
    on Frontiers in Bioinformatics, May 7, **1997**, University of
    Toronto, Canada

5.  Invited talk 'Metabolic reconstruction from sequenced bacterial
    genomes' at the Euroconference 'New Targets for New Antibiotics',
    Institute Pasteur, June 4-6, **1997**, Institute Pasteur, Paris,
    France

6.  Invited talk 'The enzyme database' at the Symposium on Designing the
    Human Physiome Project of the XXXIII Congress of the International
    Union of Physiological Sciences, July 5-8, **1997**, Pansionat
    Znamenka, St. Petersburg, Russia

7.  Invited talk 'Metabolic Reconstructions from Sequenced Genomes:
    Status and Outlook' at COMBI (Computational Biology Seminars of
    Washington University), May 6, **1998**

8.  Invited talk 'Non-Chemical Functions of Metabolic Networks:\
    Signal Amplifiers, Triggers, Oscillators, and Stable Clocks' at
    COMBI (Computational Biology Seminars of Washington University), May
    7, **1998**

9.  Invited talk 'After sequencing and metabolic reconstruction:
    Mathematical simulation of reconstructed cells' at the Annual
    Meeting of the Society of Industrial Microbiology, August 9-13,
    **1998**, Denver, Colorado

10. Invited talk (in co-authorship with M. Fonstein et al) 'Metabolic
    reconstruction of *Zymomonas mobilis* and *Thiobacillus
    ferrooxidans* based on their gapped genome sequencing' at the Annual
    Meeting of the Society of Industrial Microbiology, August 9-13,
    **1998**, Denver, Colorado

11. Invited talk 'How far we can go in reconstructing cellular life from
    sequenced genome' at the Conference on Metabolic Engineering II of
    the United Engineering Foundation. October 25-30, **1998**, Schloss
    Elmau, Germany

12. Invited talk: 'Metabolic reconstruction technology: status and
    outlook' at the Pasteur Foundation Meeting 'Mining Bacterial
    Genomes', April 16-17, **1999**, CNR, Rome, Italy

13. *Invited talk 'Mathematical simulation in reconstructing cellular
    organization' at In Silico Biology - Data Acquisition and Model
    Development, June, 8-10, **1999**, San-Francisco,\
    California*

14. *Invitation to '1999 Physiome Symposium -- The Integrated Biology of
    the Heart', University of Washington, September 9-11, **1999**,
    Seattle, WA*

15. Invited participant of the Virtual Human Roadmapping Workshop of
    NAS-DOE. November 8-9, **1999**, Rockville, MD

16. Invited talk 'EMP and MPW databases of enzymes and metabolic
    pathways. Status and outlook' at the Workshop on the Development of
    Interactive Databases" of the National Institute of General Medical
    Sciences, November 11-12, **1999**, NIH, Bethesda, MD

17. Invited talk "Metabolic reconstruction from sequenced genomes" at
    ASM and Institute Pasteur Joint Conference 'Genomes 2000:
    International Conference on Microbial and Model Genomes', April
    11-15, **2000**, Institute Pasteur, Paris, France

18. *Invitation to take part in a session on Bioinformatics Modeling of
    the 16^th^ IMACS World Congress 2000, August 21-25, **2000**,
    Lausanne, Switzerland*

19. *Invited talk 'Pathway reconstruction' at the NSF Workshop on In
    Silico Modeling of Complex Biological Phenomena, May 31, **2000**,
    San-Diego, California*

20. *Invitation to take part in a workshop 'Lymphocyte Signal
    Transduction', October 11-15, **2000**, Nomicos Conference Center,
    Greece*

21. *Invitation to take part in a workshop 'The Physiome' at the Meeting
    of Biomedical Engineering Society, October 12-14, **2000**, Seattle,
    Washington*

22. Invited talk at the Conference on Genetics and Molecular Biology of
    Industrial Microorganisms of the Society of Industrial Microbiology,
    October 15-19, **2000**, Indiana University, Bloomington,

23. *Invitation to take part in a workshop 'Innate Immunity', October
    16-20, **2000**, Nomicos Conference Center, Greece*

24. Invited co-chairmanship and talk at the Conference on Genetics and
    Molecular Biology of Industrial Microorganisms of the Society of
    Industrial Microbiology, October 15-19, **2000**, Indiana
    University, Bloomington

25. *Invitation to deliver a talk on metabolic bioinformatics at the
    Functional Genomics Conference of IBC USA Conferences, October
    16-19, **2000**, Phoenix, AZ*

26. Invited talk 'Filling the missing pieces of biochemistry: the role
    of bioinformatics' at the Conference on Metabolic Engineering III of
    the United Engineering Foundation. October 22-27, **2000**, Colorado
    Springs, Colorado

27. *Invited talk at the Symposium on Applied Molecular Evolution at the
    Society for Molecular Biology and Evolution annual meeting, July
    7-10, **2001**, Athens, Georgia.*

28. *Invited speaker at the 2001 Annual Meeting of the Society of
    Industrial Microbiology, July 29-August 2, **2001**, St. Louis, MO*

29. *Invited talk 'How Far to Go from Genome Sequencing to Predicting
    the Dynamic Behavior of the Cell Metabolism' at The First DFG/NWO
    Meeting 'Entering the Living Cell' 28 -- 30 September **2001**,
    Egmond aan Zee, The Netherlands*

30. Invited plenary talk 'Reconstructing Metabolic Pathways from
    Sequenced Bacterial Genomes' at the Annual Meeting of the German
    Society for General and Applied Microbiology (VAAM). The meeting
    will be held at University of Goettingen, on March 24-27, **2002**