Russian Health Studies Program

Peer Reviewed Publications and Outcomes

December 31, 2008

+----+---------+----------+-----------+------+-----------------------+
| *  | **      | **U.S.   | **Russian | **Nu | # Outcomes            |
| *P | Project | PI**     | PI**      | mber |                       |
| ro | Name**  |          |           | of   |                       |
| je |         |          |           | P    |                       |
| ct |         |          |           | eer- |                       |
| Nu |         |          |           | Revi |                       |
| mb |         |          |           | ewed |                       |
| er |         |          |           | Pu   |                       |
| ** |         |          |           | blic |                       |
|    |         |          |           | atio |                       |
|    |         |          |           | ns** |                       |
+====+=========+==========+===========+======+=======================+
| 1  | Techa   | Lynn     | Marina    | 79   | This project provides |
| .1 | River   | Anspaugh | Degteva   |      | the foundation for    |
|    | Pop     |          |           |      | the derivation of     |
|    | ulation | ### Un   | *Urals    |      | radiation risk from   |
|    | Do      | iversity | Research  |      | studies of the Techa  |
|    | simetry |  of Utah | Center    |      | River Cohort. It      |
|    |         |          | for       |      | provides the          |
|    | 19      |          | Radiation |      | dosimetry data for    |
|    | 99-2003 |          | Medicine* |      | Project 1.2b, Techa   |
|    |         |          |           |      | River Population      |
|    | 20      |          |           |      | Morbidity. This study |
|    | 04-2006 |          |           |      | is important because  |
|    |         |          |           |      | it addresses the      |
|    | 20      |          |           |      | question of           |
|    | 07-2009 |          |           |      | radiogenic risk from  |
|    |         |          |           |      | dose received at low  |
|    |         |          |           |      | dose rates. In        |
|    |         |          |           |      | addition, this        |
|    |         |          |           |      | project is providing  |
|    |         |          |           |      | valuable, new         |
|    |         |          |           |      | information for       |
|    |         |          |           |      | improving dose        |
|    |         |          |           |      | estimation from the   |
|    |         |          |           |      | intake of ^90^Sr.     |
|    |         |          |           |      | Current work is       |
|    |         |          |           |      | directed to           |
|    |         |          |           |      | completion of the     |
|    |         |          |           |      | Techa River Dosimetry |
|    |         |          |           |      | System-2009.          |
+----+---------+----------+-----------+------+-----------------------+
| 1. | Data    | Donna    | Nikolai   | 1    | This completed        |
| 2a | Prese   | Cragle   | Startsev  |      | project established a |
|    | rvation |          |           |      | document imaging      |
|    | at      | *Oak     | *Urals    |      | system at URCRM for   |
|    | URCRM   | Ridge    | Research  |      | preserving valuable   |
|    |         | I        | Center    |      | medical records of    |
|    | 19      | nstitute | for       |      | residents of the      |
|    | 97-2005 | for      | Radiation |      | Southern Urals region |
|    |         | Science  | Medicine* |      | exposed to radiation  |
|    |         | and      |           |      | due to the operations |
|    |         | Ed       |           |      | of the Mayak facility |
|    |         | ucation* |           |      | and environmental     |
|    |         |          |           |      | releases. These       |
|    |         |          |           |      | documents contain     |
|    |         |          |           |      | information from 1951 |
|    |         |          |           |      | to the present with   |
|    |         |          |           |      | details of medical    |
|    |         |          |           |      | examinations,         |
|    |         |          |           |      | individual dose       |
|    |         |          |           |      | measurements,         |
|    |         |          |           |      | addresses, causes of  |
|    |         |          |           |      | death, and other data |
|    |         |          |           |      | necessary for         |
|    |         |          |           |      | epidemiologic studies |
|    |         |          |           |      | and dose              |
|    |         |          |           |      | reconstruction.       |
|    |         |          |           |      | Computer scanning     |
|    |         |          |           |      | equipment was         |
|    |         |          |           |      | purchased, installed, |
|    |         |          |           |      | and later updated.    |
|    |         |          |           |      | Scanning,             |
|    |         |          |           |      | verification,         |
|    |         |          |           |      | indexing, and         |
|    |         |          |           |      | creation of a         |
|    |         |          |           |      | computer database of  |
|    |         |          |           |      | the scanned documents |
|    |         |          |           |      | were completed.       |
+----+---------+----------+-----------+------+-----------------------+
| 1. | Techa   | Faith    | Alexander | 25   | The combined work of  |
| 2b | River   | Davis    | Akleyev   |      | Projects 1.1 and 1.2b |
|    | Pop     |          |           |      | addresses the         |
|    | ulation | *Un      | *Urals    |      | important question of |
|    | Mo      | iversity | Research  |      | the validity of the   |
|    | rbidity | of       | Center    |      | dose-response model   |
|    |         | Illinois | for       |      | (linear,              |
|    | 19      | at       | Radiation |      | non-threshold) used   |
|    | 97-2003 | Chicago* | Medicine* |      | by national and       |
|    |         |          |           |      | international         |
|    | 20      |          |           |      | authorities in the    |
|    | 04-2006 |          |           |      | development of        |
|    |         |          |           |      | radiation-protection  |
|    | 20      |          |           |      | standards,            |
|    | 07-2009 |          |           |      | particularly as       |
|    |         |          |           |      | applied radiation     |
|    |         |          |           |      | delivered at low dose |
|    |         |          |           |      | rates. The Extended   |
|    |         |          |           |      | Techa River Cohort    |
|    |         |          |           |      | (ETRC) reflects a     |
|    |         |          |           |      | general population    |
|    |         |          |           |      | exposed to moderate   |
|    |         |          |           |      | doses of radiation at |
|    |         |          |           |      | low dose rates 50     |
|    |         |          |           |      | years ago. The        |
|    |         |          |           |      | population is         |
|    |         |          |           |      | relatively large      |
|    |         |          |           |      | (\~30,000) and has    |
|    |         |          |           |      | been actively         |
|    |         |          |           |      | followed so that      |
|    |         |          |           |      | results can be        |
|    |         |          |           |      | expected within a     |
|    |         |          |           |      | reasonable time       |
|    |         |          |           |      | frame. Preliminary    |
|    |         |          |           |      | results indicate an   |
|    |         |          |           |      | excess in leukemia    |
|    |         |          |           |      | and other cancers in  |
|    |         |          |           |      | this population.      |
|    |         |          |           |      | Preliminary risk      |
|    |         |          |           |      | assessment indicates  |
|    |         |          |           |      | a statistically       |
|    |         |          |           |      | significant dose      |
|    |         |          |           |      | dependence of         |
|    |         |          |           |      | incidence rates, but  |
|    |         |          |           |      | confounding sources   |
|    |         |          |           |      | of exposure and       |
|    |         |          |           |      | potential biases in   |
|    |         |          |           |      | the collection of the |
|    |         |          |           |      | outcome data in this  |
|    |         |          |           |      | population must be    |
|    |         |          |           |      | investigated and      |
|    |         |          |           |      | resolved.             |
+----+---------+----------+-----------+------+-----------------------+
| 1  | Reconst | Lynn     | Yuri      | 7    | This project is       |
| .4 | ruction | Anspaugh | Mokrov    |      | concerned with the    |
|    | of Dose |          |           |      | reconstruction of     |
|    | to the  | ### Un   | *Mayak    |      | doses to the          |
|    | Re      | iversity | P         |      | residents of Ozersk   |
|    | sidents |  of Utah | roduction |      | from the airborne     |
|    | of      |          | Ass       |      | radionuclide          |
|    | Ozersk  |          | ociation* |      | emissions from Mayak. |
|    | from    |          |           |      | Focus is on the       |
|    | Mayak   |          |           |      | emission of ^131^I    |
|    | Ope     |          |           |      | and dose to the       |
|    | rations |          |           |      | thyroid glands of     |
|    |         |          |           |      | children. Data will   |
|    | 20      |          |           |      | support an            |
|    | 03-2004 |          |           |      | epidemiologic study   |
|    |         |          |           |      | of thyroid cancer in  |
|    | 20      |          |           |      | children sponsored by |
|    | 05-2009 |          |           |      | the National Cancer   |
|    |         |          |           |      | Institute. This       |
|    |         |          |           |      | should help resolve   |
|    |         |          |           |      | the dichotomy between |
|    |         |          |           |      | the studies at        |
|    |         |          |           |      | Hanford (no observed  |
|    |         |          |           |      | effect) and Chernobyl |
|    |         |          |           |      | (large effect). The   |
|    |         |          |           |      | data also will        |
|    |         |          |           |      | determine whether     |
|    |         |          |           |      | these emissions are a |
|    |         |          |           |      | confounding factor in |
|    |         |          |           |      | the study of the      |
|    |         |          |           |      | Extended Techa River  |
|    |         |          |           |      | Cohort (Projects 1.1  |
|    |         |          |           |      | and 1.2b).            |
+----+---------+----------+-----------+------+-----------------------+
| 2  | Mayak   | Ethel    | Mikhail   | 7    | This project is the   |
| .2 | Worker  | Gilbert  | S         |      | first to demonstrate  |
|    | Mo      |          | okolnikov |      | statistically         |
|    | rtality | *        |           |      | significant           |
|    |         | National | *Southern |      | associations between  |
|    | 19      | Cancer   | Urals     |      | occupational exposure |
|    | 97-2001 | In       | B         |      | to plutonium (Pu) and |
|    |         | stitute* | iophysics |      | lung, liver, and bone |
|    | 20      |          | I         |      | cancer.               |
|    | 02-2004 |          | nstitute* |      |  Dose-response        |
|    |         |          |           |      | analyses based on     |
|    | 20      |          |           |      | Mayak Worker Doses    |
|    | 05-2007 |          |           |      | 2005 database have    |
|    |         |          |           |      | been conducted for    |
|    | 20      |          |           |      | lung, liver, and bone |
|    | 08-2010 |          |           |      | cancer and express    |
|    |         |          |           |      | the excess relative   |
|    |         |          |           |      | risk as a function of |
|    |         |          |           |      | plutonium dose,       |
|    |         |          |           |      | external dose,        |
|    |         |          |           |      | gender, and attained  |
|    |         |          |           |      | age.  Statistically   |
|    |         |          |           |      | significant           |
|    |         |          |           |      | dose-response         |
|    |         |          |           |      | relationships for     |
|    |         |          |           |      | external dose have    |
|    |         |          |           |      | also been             |
|    |         |          |           |      | demonstrated for      |
|    |         |          |           |      | leukemia; all solid   |
|    |         |          |           |      | cancer excluding      |
|    |         |          |           |      | lung, liver, and bone |
|    |         |          |           |      | cancer; and lung      |
|    |         |          |           |      | cancer.               |
+----+---------+----------+-----------+------+-----------------------+
| 2  | Mayak   | Scott    | Victor    | 50   | In addition to        |
| .4 | Worker  | Miller   | Kh        |      | providing the         |
|    | Do      |          | okhryakov |      | dosimetric data for   |
|    | simetry | ### Un   |           |      | Project 2.2, Mayak    |
|    |         | iversity | *Southern |      | Worker Mortality,     |
|    | 20      |  of Utah | Urals     |      | this project has      |
|    | 01-2003 |          | B         |      | enhanced the          |
|    |         |          | iophysics |      | understanding of Pu   |
|    | 20      |          | In        |      | metabolism in the     |
|    | 04-2006 |          | stitute*; |      | human body and        |
|    |         |          |           |      | improved the          |
|    | 20      |          | Evgeny    |      | biokinetic models for |
|    | 07-2008 |          | Vasilenko |      | assessing dose from   |
|    |         |          |           |      | Pu uptakes. These     |
|    | 20      |          | *Mayak    |      | outcomes will be of   |
|    | 09-2011 |          | P         |      | direct benefit to DOE |
|    |         |          | roduction |      | in improving the      |
|    |         |          | Ass       |      | determination of dose |
|    |         |          | ociation* |      | to DOE workers from   |
|    |         |          |           |      | Pu exposure.          |
|    |         |          |           |      | Additionally, this    |
|    |         |          |           |      | project has improved  |
|    |         |          |           |      | the interpretation of |
|    |         |          |           |      | worker external       |
|    |         |          |           |      | dosimetry and         |
|    |         |          |           |      | developed improved    |
|    |         |          |           |      | methods of estimating |
|    |         |          |           |      | organ doses based on  |
|    |         |          |           |      | dosimeter results.    |
|    |         |          |           |      | These improved        |
|    |         |          |           |      | methods can be        |
|    |         |          |           |      | applied to the        |
|    |         |          |           |      | evaluation of worker  |
|    |         |          |           |      | dose at DOE           |
|    |         |          |           |      | facilities. This task |
|    |         |          |           |      | also developed        |
|    |         |          |           |      | important             |
|    |         |          |           |      | relationships for the |
|    |         |          |           |      | role of medical       |
|    |         |          |           |      | x‑rays for worker     |
|    |         |          |           |      | exposure. Researchers |
|    |         |          |           |      | prepared the Doses    |
|    |         |          |           |      | 2005 database for     |
|    |         |          |           |      | 18,831 Mayak workers  |
|    |         |          |           |      | employed between 1948 |
|    |         |          |           |      | and 1972 and are now  |
|    |         |          |           |      | finalizing the Doses  |
|    |         |          |           |      | 2008 database for     |
|    |         |          |           |      | about 26,000 workers  |
|    |         |          |           |      | hired between 1948    |
|    |         |          |           |      | and 1982.             |
+----+---------+----------+-----------+------+-----------------------+
| 2  | I       | Raymond  | Sergey    | 11   | The earlier efforts   |
| .5 | mproved | G        | Romanov   |      | in this project       |
|    | Pl      | uilmette |           |      | focused on            |
|    | utonium |          | *Southern |      | determining the       |
|    | Dose    | *Los     | Urals     |      | amount and location   |
|    | Ass     | Alamos   | B         |      | of long-term-retained |
|    | essment | National | iophysics |      | Pu in the lungs of    |
|    | Methods | Lab      | I         |      | Mayak workers. This   |
|    | for     | oratory* | nstitute* |      | study was the first   |
|    | Mayak   |          |           |      | to demonstrate very   |
|    | Workers |          |           |      | long-term             |
|    |         |          |           |      | sequestration of Pu   |
|    | 19      |          |           |      | particles in human    |
|    | 99-2003 |          |           |      | lung parenchyma.      |
|    |         |          |           |      | Then, this knowledge  |
|    | 20      |          |           |      | of Pu distribution in |
|    | 04-2006 |          |           |      | lung was used with    |
|    |         |          |           |      | state of the art dose |
|    | 20      |          |           |      | assessment methods to |
|    | 08-2010 |          |           |      | modify the human      |
|    |         |          |           |      | respiratory tract     |
|    |         |          |           |      | dosimetry models to   |
|    |         |          |           |      | improve dose          |
|    |         |          |           |      | assessment. The main  |
|    |         |          |           |      | objective of the      |
|    |         |          |           |      | current phase is to   |
|    |         |          |           |      | obtain new knowledge  |
|    |         |          |           |      | and to implement      |
|    |         |          |           |      | additional useful     |
|    |         |          |           |      | tools that will       |
|    |         |          |           |      | facilitate the        |
|    |         |          |           |      | development of a new  |
|    |         |          |           |      | harmonized Pu         |
|    |         |          |           |      | dosimetry system,     |
|    |         |          |           |      | which will eventually |
|    |         |          |           |      | replace the Mayak     |
|    |         |          |           |      | Doses 2005 dosimetry  |
|    |         |          |           |      | system in Project     |
|    |         |          |           |      | 2.4, Mayak Worker     |
|    |         |          |           |      | Dosimetry. This       |
|    |         |          |           |      | includes addressing   |
|    |         |          |           |      | several critical      |
|    |         |          |           |      | issues for lung       |
|    |         |          |           |      | dosimetry modeling,   |
|    |         |          |           |      | combining Pu dose     |
|    |         |          |           |      | estimates with the    |
|    |         |          |           |      | uncertainties for     |
|    |         |          |           |      | individual Mayak      |
|    |         |          |           |      | workers by using      |
|    |         |          |           |      | available urine       |
|    |         |          |           |      | bioassay and/or       |
|    |         |          |           |      | postmortem tissue     |
|    |         |          |           |      | data together with    |
|    |         |          |           |      | the Bayesian approach |
|    |         |          |           |      | for individual dose   |
|    |         |          |           |      | assessment, and       |
|    |         |          |           |      | applying the          |
|    |         |          |           |      | probability           |
|    |         |          |           |      | distributions for     |
|    |         |          |           |      | intake and biokinetic |
|    |         |          |           |      | model parameters for  |
|    |         |          |           |      | assessing the dose    |
|    |         |          |           |      | for workers monitored |
|    |         |          |           |      | for Pu to Mayak       |
|    |         |          |           |      | workers for whom      |
|    |         |          |           |      | little or no Pu       |
|    |         |          |           |      | monitoring data are   |
|    |         |          |           |      | available.            |
+----+---------+----------+-----------+------+-----------------------+
| 2  | Mo      | Steve    | Vitaly    | 4    | The original project  |
| .6 | lecular | Belinsky | Telnov    |      | demonstrated that the |
|    | Markers |          |           |      | p16 tumor suppressor  |
|    | of Lung | *        | *Southern |      | gene was targeted for |
|    | Cancer  | Lovelace | Urals     |      | inactivation by       |
|    | in      | Res      | B         |      | promoter              |
|    | Mayak   | piratory | iophysics |      | hypermethylation in   |
|    | Workers | Research | I         |      | plutonium-induced     |
|    |         | In       | nstitute* |      | adenocarcinomas of    |
|    | 20      | stitute* |           |      | the lung. The current |
|    | 00-2002 |          |           |      | phase of the research |
|    |         |          |           |      | is to examine         |
|    | 20      |          |           |      | methylation profiles  |
|    | 03-2008 |          |           |      | in adenocarcinomas    |
|    |         |          |           |      | and squamous cell     |
|    |         |          |           |      | carcinomas of the     |
|    |         |          |           |      | lung in Mayak workers |
|    |         |          |           |      | and controls.         |
+----+---------+----------+-----------+------+-----------------------+
| 2  | Ra      | David    | Tamara    | 5    | The feasibility study |
| .7 | diation | Brenner  | Azizova   |      | indicated a           |
|    | Bio     |          |           |      | statistically         |
|    | markers | ### Col  | *Southern |      | significant           |
|    |         | umbia Un | Urals     |      | dose-response between |
|    | 20      | iversity | B         |      | Pu exposure and       |
|    | 01-2002 |          | iophysics |      | intra-arm chromosomal |
|    |         |          | I         |      | aberrations from      |
|    | 20      |          | nstitute* |      | worker blood samples. |
|    | 03-2008 |          |           |      | This study may lead   |
|    |         |          |           |      | to the development of |
|    |         |          |           |      | a dose-related        |
|    |         |          |           |      | biomarker of Pu       |
|    |         |          |           |      | exposure.             |
+----+---------+----------+-----------+------+-----------------------+
| 2  | Mayak   | Chr      | Klara     | 12   | The Mayak Worker      |
| .8 | Worker  | istopher | Muksinova |      | Tissue Repository now |
|    | Tissue  | Loffredo |           |      | holds tissues from    |
|    | Rep     |          | *Southern |      | 1,000 deceased        |
|    | ository | #        | Urals     |      | workers,              |
|    |         | ## Georg | B         |      | surgical/biopsy       |
|    | 19      | etown Un | iophysics |      | tissue samples from   |
|    | 98-2002 | iversity | I         |      | 500 donors, and blood |
|    |         |          | nstitute* |      | DNA, cells, serum     |
|    | 20      |          |           |      | samples from 4,800    |
|    | 03-2007 |          |           |      | professionals and     |
|    |         |          |           |      | residents of Ozersk.  |
|    | 20      |          |           |      | In conjunction with   |
|    | 08-2012 |          |           |      | medical,              |
|    |         |          |           |      | occupational, and     |
|    |         |          |           |      | dosimetry             |
|    |         |          |           |      | information, data     |
|    |         |          |           |      | collected in the      |
|    |         |          |           |      | repository will make  |
|    |         |          |           |      | possible the conduct  |
|    |         |          |           |      | of molecular          |
|    |         |          |           |      | epidemiology studies. |
|    |         |          |           |      | Such studies combine  |
|    |         |          |           |      | epidemiologic with    |
|    |         |          |           |      | genetic/molecular     |
|    |         |          |           |      | methods to establish  |
|    |         |          |           |      | an association        |
|    |         |          |           |      | between disease and   |
|    |         |          |           |      | radiation exposure in |
|    |         |          |           |      | individuals.          |
+----+---------+----------+-----------+------+-----------------------+
| 2  | D       | Dale     | Sergey    | 0    | This project is meant |
| .9 | atabase | Preston  | Romanov   |      | to combine databases  |
|    | Inte    |          |           |      | located in two        |
|    | gration | *        | *Southern |      | Russian organizations |
|    |         | Hirosoft | Urals     |      | so as to facilitate   |
|    | 20      | Intern   | B         |      | researcher access to  |
|    | 01-2005 | ational* | iophysics |      | data. As such, it is  |
|    |         |          | In        |      | not intended to       |
|    |         | Eric     | stitute*; |      | result in             |
|    |         | Grant    |           |      | publications or       |
|    |         |          | Evgeny    |      | influence radiation   |
|    |         | *R       | Vasilenko |      | protection standards. |
|    |         | adiation |           |      |                       |
|    |         | Effects  | *Mayak    |      |                       |
|    |         | Research | P         |      |                       |
|    |         | Fou      | roduction |      |                       |
|    |         | ndation* | Ass       |      |                       |
|    |         |          | ociation* |      |                       |
+----+---------+----------+-----------+------+-----------------------+

As of December 31, 2008, U.S. and Russian investigators working on
projects funded by the Russian Health Studies Program have generated 201
peer-reviewed publications.

Russian Health Studies Program

201 Peer Reviewed Publications

December 31, 2008

> **Project 1.1: Techa River Population Dosimetry (79)**

1.  Akleyev, A.V.; Krestinina, L.Y.; Preston, D.; Davis, F.; Degteva,
    M.O.; Anspaugh, L.; Startsev, N.V.; Napier, B.; Ron, E. Radiogenic
    risk of malignant neoplasms for Techa Riverside residents. *Med.
    Radiol. Radiat. Saf.* 53:13--37; 2008 (in Russian).

2.  Anspaugh, L.R.; Degteva, M.O.; Vasilenko, E.K. Mayak Production
    Association: Introduction. *Radiat. Environ. Biophys.* 41:19--22;
    2002.

3.  Anspaugh, L.R.; Shishkina, E.A.; Shved, V.A.; Degteva, M.O.;
    Tolstykh, E.I.; Napier, B.A. Comment on paper by Hayes, Haskell, and
    Kenner. *Health Phys.* 85:622--624; 2003.

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6.  Bougrov, N.G.; Göksu, H.Y.; Haskell, E.; Degteva, M.O.; Meckbach,
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7.  Bougrov, N.G.; Degteva, M.O.; Göksu, H.Y.; Meckbach, R.; Jacob, P.
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8.  Bougrov, N.G.; Baturin, V.A.; Göksu, H.Y.; Degteva, M.O.; Jacob, P.
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12. Degteva, M.O.; Vorobiova, M.I.; Kozheurov, V.P.; Tolstykh, E.I.;
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13. Degteva, M.O.; Kozheurov, V.P.; Tolstykh, E.I.; Vorobiova, M.I.;
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17. Degteva, M.O.; Tolstykh, E.I.; Vorobiova, M.I. Assessment of doses
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19. Degteva, M.O.; Tolstykh, E.I.; Vorobiova, M.I.; Shagina, N.B.;
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23. Glagolenko, Y.V.; Drozhko, E.G.; Mokrov,Y.G.; Rovny, S.I.; Stukalov,
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26. Göksu, H.Y.; Semiochkina, N.; Shishkina, E.A.; Wieser, A.;
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28. Jacob, P.; Göksu, Y.; Taranenko, V.; Meckbach, R.; Bougrov, N.G.;
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29. Khokhryakov, V.V.; Drozhko, E.G.; Glagolenko, Y.V.; Rovny, S.I.;
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30. Koshta, A.A.; Wieser, A.; Ignatiev, E.A.; Bayankin, S.; Romanyukha,
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31. Kovtun, A.N.; Puzikov, A.G.; Sokolov, I.A.; Kozheurov, V.P.;
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32. Kozheurov, V.P.; Zalyapin, V.I.; Shagina, N.B.; Tokareva, E.E.;
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33. Levina, S.G.; Shagina, N.B.; Akleyev, A.V.; Zakharov, S.G.;
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34. Napier, B.A.; Shagina, N.B.; Degteva, M.O.; Tolstykh, E.I.;
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35. Peremyslova, L.M.; Kostyuchenko, V.A.; Degteva, M.O.; Baturin, V.A.;
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36. Phipps, A.W.; Tolstykh, E.I.; Shagina, N.B.; Harrison, J.D.;
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37. Romanyukha, A.A.; Degteva, M.O.; Kozheurov, V.P.; Wieser, A.; Jacob,
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38. Romanyukha, A.A.; Ignatiev, E.A.; Degteva, M.O.; Kozheurov, V.P.;
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39. Romanyukha, A.A.; Hayes, R.B.; Haskell, E.H.; Kenner, G.H.
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40. Romanyukha, A.A.; Seltzer, S.M.; Desrosiers, M.; Ignatiev, E.A.;
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41. Romanyukha, A.A.; Mitch, M.G.; Lin, Z.; Nagy, V.; Coursey, M.
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42. Shagina, N.B.; Tolstykh, E.I.; Zalyapin, V.I.; Degteva, M.O.;
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43. Shagina, N.B.; Tolstykh, E.I.; Degteva, M.O. Improvements in the
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44. Shagina, N.B.; Bougrov, N.G.; Degteva, M.O.; Kozheurov, V.P.;
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45. Shagina, N.B.; Degteva, M.O.; Tolstykh, E.I.; Zalyapin, V.I.;
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46. Shagina, N.B.; Tolstykh, E.I.; Fell, T.P.; Harrison, J.D.; Phipps,
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47. [Shibkova, D.Z.; Efimova, N.V.; Tolstykh, E.I.; Andreeva,
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48. Shishkina, E.A.; Lyubashevskii, N.M.; Tolstykh, E.I.; Ignatiev,
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49. Shishkina, E.A.; Degteva, M.O.; Shved, V.A.; Ivanov, D.V.; Bayankin,
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50. Shishkina, E.A.; Göksu, H.Y.; El-Faramawy, N.A.; Semiochkina, N.
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51. Shishkina, E.A.; Degteva, M.O.; Tolstykh, E.I.; Shved, V.A.;
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52. Straume, T.; Anspaugh, L.R.; Haskell, E.H.; Lucas, J.N.; Marchetti,
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53. Taranenko, V.; Meckbach, R.; Degteva, M.O.; Bougrov, N.G.; Göksu,
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54. Tikunov, D.D.; Ivannikov, A.I.; Shishkina, E.A.; Petin, D.V.;
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55. Tolstykh, E.I.; Kozheurov, V.P.; Vyushkova, O.V.; Degteva, M.O.
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56. Tolstykh, E.I.; Degteva, M.O.; Kozheurov, V.P.; Burmistrov, D.S.
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57. Tolstykh, E.I.; Degteva, M.O.; Kozheurov, V.P.; Shishkina, E.A.;
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58. Tolstykh, E.I.; Degteva, M.O.; Shagina, N.B.; Kozheurov, V.P.;
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59. Tolstykh, E.I.; Degteva, M.O.; Peremislova, L.M.; Vorobiova, M.I.;
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60. Tolstykh, E.I.; Degteva, M.O.; Vorobiova, M.I.; Kozheurov, V.P.
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61. Tolstykh, E.I.; Degteva, M.O.; Vorobiova, M.I.; Kozheurov, V.P.;
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62. Tolstykh, E.I.; Degteva, M.O.; Shagina, N.B.; Kozheurov, V.P.;
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63. Tolstykh, E.I.; Shishkina, E.A.; Degteva, M.O.; Ivanov, D.V.;
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64. Tolstykh, E.I.; Tokareva, E.E.; Peremyslova, L.M.; Degteva, M.O.
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65. Tolstykh, E.I.; Peremyslova, L.M.; Shagina, N.B.; Degteva, M.O.;
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66. Tolstykh, E.I.; Degteva, M.O.; Peremyslova, L.M.; Shagina, N.B.;
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67. Tolstykh, E.I.; Degteva, M.O.; Vorobiova, M.I.; Peremyslova, L.M.;
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68. Tolstykh, E.I.; Degteva, M.O.; Shishkina, E.A.; Zalyapin, V.I.;
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69. Tolstykh, E.I.; Shagina, N.B.; Peremyslova, L.M.; Degteva, M.O.;
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70. Trapeznikov, A.V.; Molchanova, I.V.; Karavaeva, E.N.; Peremyslova,
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71. Veronese, I.; Shved, V.; Shishkina, E.A.; Giussani, A.; Göksu, H.Y.
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72. Veronese, I.; Fattibene, P.; Cantone, M.C.; De Coste, V.; Giussani,
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73. Vorobiova, M.I.; Degteva, M.O.; Burmistrov, D.S.; Safronova, N.G.;
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74. Vorobiova, M.I.; Degteva, M.O. Simple model for the reconstruction
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75. Wieser, A.; Romanyukha, A.A.; Degteva, M.O.; Kozheurov, V.P.;
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76. Wieser, A.; Fattibene, P.; Shishkina, E.A.; Ivanov, D.V.; De Coste,
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77. Zalyapin, V.I.; Krivoshchapov, V.A. Numerical analysis of one
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78. Zalyapin, V.I.; Krivohchapov, V.A.; Degteva, M.O. Numerical analysis
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79. Zalyapin, V.I.; Shishkina, E.A.; Fattibene, P.; Wieser, A.; Ivanov,
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# 

# Project 1.2a: Data Preservation at URCRM (1)

1.  Startsev, N.V.; Shalonin, D.G.; Cragle, D.; Klein, A.; Akleyev, A.V.
    Approach to physical preservation of archival records accumulated at
    the Urals Research Center for Radiation Medicine. *Med. Radiology
    and Radiation Safety* 6:107--112; 2001 (in Russian).

# 

# Project 1.2b: Techa River Population Morbidity (25)

1.  Akleyev, A.V.; Kossenko, M.M.; Silkina, L.A.; Degteva, M.O.
    Clinical-epidemiological basis for identification of exposed
    population groups at high risk of cancer development. *Radiation and
    Risk* 5:163--182; 1995 (in Russian).

2.  Akleyev, A.V.; Kossenko, M.M.; Silkina, L.A.; Degteva, M.O.;
    Yachmenyov, V.A.; Awa, A.; Akiyama, M.; Veremeyeva, G.A.; Voziliva,
    A.V.; Kyazumi, S.; Kozheurov, V.P.; Vyushkova, O.V. Health effects
    of radiation incidents in the Southern Urals. *Stem Cells*
    13:58--68; 1995.

3.  Akleyev, A.V.; Zhidkova, C. The Chelyabinsk data base: current
    Russian legislation on database and intellectual property and its
    implications for international scientific collaboration. *Health
    Phys.* 71:58--60; 1996.

4.  Akleyev, A.V.; Kossenko, M.M.; Startsev, N.V. Techa River
    population: long-term medical follow-up. *British Journal of
    Radiology*, Supplement 26:32--40; 2002.

5.  Akleyev, A.V.; Krestinina, L.Yu.; Preston, D. Carcinogenic effects
    of protracted radiation exposure among residents of the Techa river
    villages. *International Journal of Cancer* Suppl. 13:127--128;
    2002.

6.  Akleyev, A.V.; Preston, D.; Krestinina, L.Yu. Medical-biological
    effects of chronic radiation exposure in man. *Occupational Medicine
    and Industrial Ecology* 3:30--36; 2004 (in Russian).

7.  Akleyev, A.; Davis, F., Krestinina, L., Preston D. The Techa River
    Cancer Incidence subcohort: description and preliminary follow-up
    results. In *Proceedings of the 11^th^ International Congress of the
    IRPA*, Madrid, 23--28 May, 2004. Session 1b1.
    [http://irpa11.irpa.net](http://irpa11.irpa.net/)

8.  Akleyev, A.V.; Krestinina, L.Y.; Preston, D.; Davis, F.; Degteva,
    M.O.; Anspaugh, L.; Startsev, N.V.; Napier, B.; Ron ,E. Radiogenic
    risk of malignant neoplasms for Techa riverside residents. *Medical
    radiology and radiation safety (Meditsinskaya Radiologiia I
    Radiatsionnaia Bezopasnost)* 53:6; 2008 (in Russian and in English).

9.  Burmistrov, D.; Kossenko, M.; Wilson, R. Radioactive contamination
    of the Techa River and its effects. *Technology* 7:553*--*575; 2000.

10. Ilyin, L.A.; Akleyev, A.V.; Romanov, S.A. Progress in radiobiology
    research and radiation medicine achieved by institutes within the
    system of Federal Medical and Biological Agency of Russia.
    *Emergency Medicine* 21:68--82; 2007 (in Russian).

11. Kossenko, M.M. Cancer mortality in the exposed population of the
    Techa River area. *World Health Stat. Q*. 49:17*--*21; 1996.

12. Kossenko, M.M. Cancer mortality among Techa river residents and
    their offspring. *Health Phys*. 71:77*--*82; 1996.

13. Kossenko, M.M.; Degteva, M.O.; Vyushkova, O.V.; Preston, D.L.;
    Mabuchi, K.; Kozheurov, V.P. Issues in the comparison of risk
    estimates for the population in the Techa River Region and Atomic
    Bomb Survivors. *Radiat. Res*. 148:54*--*63; 1997.

14. Kossenko, M.M.; Degtyaryova, R.G.; Petrushova, N.A. Clinical and
    epidemiological characteristics of leukemia cases among population
    exposed to chronic irradiation. *Hematology and Transfusiology*
    42:27*--*31; 1997 (in Russian).

15. Kossenko, M.M.; Akleyev, A.V.; Startsev, N.A.; Degteva, M.O.
    Epidemiological analysis of remote carcinogenic effects on
    populations with chronic exposure to radiation in the Urals region.
    *Int. J. Radiat. Med.* 2:34*--*41; 1999.

16. Kossenko, M.M.; Hoffman, D.A.; Thomas, T.L. Stochastic effects of
    environmental radiation exposure in populations living near the
    Mayak Industrial Association: preliminary report on study of cancer
    morbidity. *Health Phys*. 79:55*--*62; 2000.

17. Kossenko, M.M.; Ostroumova, E.V.; Krestinina, L.Yu.; Vyushkova,
    O.V.; Epifanova, O.V.; Gudkova, N.V.; Thomas, T.L.; Hoffman, D.A.;
    Preston, D.L.; Akleyev, A.V. Analysis of Cancer morbidity among the
    exposed residents of the Techa riverside villages. *Meditsinskaia
    Radiologiya i Radiatsionnaya Bezopasnost* (Medical Radiology and
    Radiation Safety), V. 46, *№*6 Moscow: Radekon, 2001 (in Russian).

18. Kossenko, M.M.; Preston, D.L.; Krestinina, L.Y.; Degteva, M.O.;
    Startsev, N.V.; Thomas, T.L.; Vyushkova, O.V.; Anspaugh, L.R.;
    Napier, B.A.; Kozheurov, V.P.; Ron, E.; Akleyev, A.V. Studies on the
    extended Techa River cohort: cancer risk estimation. *Radiat.
    Environ. Biophys.* 41:45--48; 2002.

19. Kossenko, M.M.; Akleyev, A.V.; Krestinina, L.Yu.; Startsev, N.V.;
    Zhidkova, C.; Hoffman, D.A.; Thomas, T.L.; Preston, D. Methods for
    following-up a cohort of people exposed on the Techa River.
    *Siberian Medical Journal* 18:40--49; 2003 (in Russian).

20. Kossenko, M.M.; Thomas, T.L.; Akleyev, A.V.; Krestinina, L.Y.;
    Startsev, N.V.; Vyushkova, O.V.; Zhidkova, C.M.; Hoffman, D.A.;
    Preston, D.L.; Davis, F.; Ron, E. The Techa River Cohort: Study
    Design and Follow-up Methods.
    [http://www.bioone.org/bioone/?request=get-abstract&doi=10.1043/0033-7587(2005)164\[0591:TTRCSD\]2.0.CO;2](http://www.bioone.org/bioone/?request=get-abstract&doi=10.1043/0033-7587(2005)164[0591:TTRCSD]2.0.CO;2).
    *Radiat. Res.* 164:591--601; 2005.

21. Krestinina, L.Yu.; Preston, D.; Ostroumova, E.V.; Ron, E.;
    Vyushokova, O.V.; Akleyev, A.V. Cancer mortality in a cohort of
    people exposed on the Techa River: preliminary risk estimation.
    *Siberian Medical Journal* 2:52--62; 2005 (in Russian).

22. Krestinina, L.Y.; Preston, D.L.; Ostroumova, E.V.; Degteva, M.O.;
    Ron, E.; Vyushokova, O.V.; Startsev, N.V.; Kossenko, M.M., Akleyev,
    A.V. Protracted Radiation Exposure and Cancer Mortality in the Techa
    River Cohort.
    [http://www.bioone.org/bioone/?request=get-abstract&doi=10.1043/0033-7587(2005)164\[0602:PREACM\]2.0.CO;2](http://www.bioone.org/bioone/?request=get-abstract&doi=10.1043/0033-7587(2005)164[0602:PREACM]2.0.CO;2).
    *Radiat. Res.* 164:602--611; 2005.

23. Krestinina, L.Y.; Davis F.; Ostroumova, E.V.; Epifanova, S.B.;
    Degteva, M.O.; Preston, D.L.; Akleyev, A.V. Solid cancer incidence
    and low-dose-rate radiation exposures in the Techa River cohort:
    1956--2002. *International Journal of Epidemiology*
    36:1038--1046; 2007.
    PDF:<http://ije.oxfordjournals.org/cgi/reprint/dym121?ijkey=SfOmBABjefzUDBW&keytype=ref>

24. Ostroumova, E.; Preston, D.L.; Ron, E.; Krestinina, L.; Davis, F.G.;
    Kossenko, M.; Akleyev, A. Breast cancer incidence following low-dose
    rate environmental exposure: Techa River Cohort, 1956--2004.
    *Brit. J. Cancer* 99:1940--1945; 2008.

25. Segerstahl, B.; Akleyev, A.V.; Novikov, V. The long shadow of Soviet
    plutonium production. *Environment* 39:12--20; 1997.

# 

# Project 1.4: Reconstruction of Dose to Residents of Ozersk from Mayak Operations (7)

1.  Glagolenko, Yu.V.; Drozhko, E.G.; Mokrov, Yu.G.; Rovny, S.I.;
    Stukalov, P.M.; Lyzhkov, A.V.; Alexandrova, O.N. Assessment of
    effective cooling period for irradiated uranium in reactor "A"
    storage pool in 1948--1954. *Radiat. Safety Problems* (Mayak
    Production Association Scientific Journal) 3:75--79; 2006 (in
    Russian).

2.  Report of the First Central Directorate Committee under the Guidance
    of Alexandrov, A.P. Concerning Contamination of the Territory
    Adjacent to Mendeleev Plant (1951). *Radiat. Safety Problems* (Mayak
    Production Association Scientific Journal) 3: 60--74; 2006 (in
    Russian).

3.  Glagolenko, Yu.V.; Drozhko, E.G.; Mokrov, Yu.G.; Pyatin, N.P.;
    Rovny, S.I.; Anspaugh, L.R.; Napier, B.A. Methods and results of
    reconstruction of noble gas releases from the stacks of the Mayak PA
    graphite reactors over the whole period of their operation. *Radiat.
    Safety Problems* (Mayak Production Association Scientific Journal)
    Special Issue: 5--19; 2008.

4.  Glagolenko, Yu.V.; Drozhko, E.G.; Mokrov, Yu.G.; Rovny, S.I.;
    Beregich, D.A.; Stukalov, P.M.; Ivanov, I.A.; Alexakhin, A.I.;
    Anspaugh, L.R.; Napier, B.A. Reconstruction of external doses to
    Ozyorsk residents due to atmospheric releases of inert radioactive
    gases from the stacks of the "Mayak PA" reactor production from 1948
    to 1989. *Radiat. Safety Problems* (Mayak Production Association
    Scientific Journal) Special Issue: 20--31; 2008.

5.  Glagolenko, Yu.V.; Drozhko, E.G.; Mokrov, Yu.G.; Rovny, S.I.;
    Lyzhkov, A.V.; Anspaugh, L.R.; Napier, B.A. Methods for
    reconstruction of radionuclide composition and activity of fission
    products accumulated in the irradiated uranium at the moment of its
    radiochemical reprocessing at Plant "B", "Mayak" PA in the early
    1950s. *Radiat. Safety Problems* (Mayak Production Association
    Scientific Journal) Special Issue: 32--47; 2008.

6.  Glagolenko, Yu.V.; Drozhko, E.G.; Mokrov, Yu.G.; Pyatin, N.P.;
    Rovny, S.I.; Anspaugh, L.R.; Napier, B.A. Reconstruction of ^131^I
    releases from stacks of the radiochemical plant of the Mayak
    Production Association for the period from 1948 to 1967. *Radiat.
    Safety Problems* (Mayak Production Association Scientific Journal)
    Special Issue: 48--57; 2008.

7.  Mokrov, Yu.G.; Martyushov, V.Z.; Stukalov, P.M.; Ivanov, I.A.;
    Beregich, D.A.; Anspaugh, L.R.; Napier, B.A. Food consumption
    patterns of the Ozyorsk population in 1948--1966, important for
    estimating per oral component of internal exposure doses. *Radiat.
    Safety Problems* (Mayak Production Association Scientific Journal)
    Special Issue: 58--71; 2008.

> **Project 2.2: Mayak Worker Epidemiology (7)**

1.  Gilbert, E.S.; Koshurnikova, N.A.; Sokolnikov, M.; Khokhryakov,
    V.F.; Miller, S.; Preston, D.L.; et al: Liver Cancers in Mayak
    Workers. *Radiat. Res.* 154:246*--*252; 2000.

2.  Gilbert, E.S.; Koshurnikova, N.A.; Sokolnikov, M.E.; Shilnikova,
    N.S.; Preston, D.L.; Ron, E.; Khokhryakov, V.F.; Vasilenko, E.K.;
    Miller, S.; Eckerman, K.; Romanov, S.A. Lung cancers in Mayak
    workers. *Radiat. Res.* 162:505*--*516; 2004.

3.  Koshurnikova, N.A.; Gilbert, E.S.; Sokolnikov. M.; Khokhryakov,
    V.F.; Miller, S.; Preston, D.L.; et al: Bone Cancers in Mayak
    Workers. *Radiat. Res.* 154:237*--*245; 2000.

4.  Koshurnikova, N.A.; Gilbert, E.S.; Shilnikova, N.S.; Sokolnikov, M.;
    Preston, D.L.; Kreisheimer, M.; Ron, E.; Kellerer, A.M.; Okatenko,
    P.; Romanov, S.A. Studies on the Mayak nuclear workers: health
    effects. *Radiation and Environmental Biophysics* 41:29*--*31; 2002.

5.  Shilnikova, N.A.; Preston, D.L.; Ron, E.; Gilbert, E.S.; Vasilenko,
    E.K.; Romanov, S.A.; Kuznetsova, I.S.; Sokolnikov, M.E.; Okatenko,
    P.V.; Kreslov, V.V.; Koshurnikova, N.A. Cancer mortality risk among
    workers at the Mayak nuclear complex.  *Radiat. Res.*
    159:787*--*798; 2003.

6.  Koshurnikova, N.A.; Shilnikova, N.S.; Sokolnikov, M.E.; Bolotnikova,
    M.G.; Okatenko, P.V.; Kuznetsova, I.S. Medical-Dosimetry registry of
    workers at the \"Mayak\" production association. *International
    Journal of Low Radiation* 2:236--242; 2006.

7.  Sokolnikov, M.E.; Gilbert, E.S.; Preston, D.L.; Ron, E.; Shilnikova,
    N.S.; Khokhryakov, V.V.; Vasilenko, E.K.; Koshurnikova, N.A. Lung,
    liver, and bone cancer mortality in Mayak workers. *International
    Journal of Cancer* 123:905--911; 2008.

# Project 2.4: Mayak Worker Dosimetry (50)

1.  Bailey, B.R.; Eckerman, K.F.; Townsend, L.W. An analysis of a
    puncture wound case with medical intervention. *Radiat. Prot.
    Dosim.* 105:509--512; 2003.

2.  Bess, J.D., Krahenbuhl, M.P., Miller, S.C., Khokhryakov, V.V.,
    Khokhryakov, V.F., Suslova, K.G., Vostrotin, V.V. Uncertainties
    analysis for the plutonium dosimetry model, doses 2005, using Mayak
    bioassay data. *Health Physics* 93:207--219; 2007.

3.  Choe, D.O.; Shelkey, B.N.; Wilde, J.L.; Walk, H.A.; Slaughter D.A.
    Calculated organ doses for Mayak production association central hall
    using ICRP and MCNP. *Health Physics* 84:317--321; 2003.

4.  Ilyin, L.A.; Kiselev, M.F.; Panfilov, A.P.; Kochetkov, O.A.; Ivanov,
    A.A.; Grinev, M.P.; Soloviev, V.Yu.; Semenov, V.G.; Tukov, A.R.;
    Romanov, S.A.; Koshurnikova, N.A.; Khokhryakov, V.F.; Kuznetsova,
    I.S. Medical dosimetric registry of Russian atomic industry
    employees: current status and perspectives. *Int. J. of Low
    Radiation* 2:207--218; 2006.

5.  Jacob, P.; Meckbach, R.; Sokolnikov, M.; Khokhryakov, V.V.;
    Vasilenko, E. Lung cancer risk of Mayak workers: modeling of
    carcinogenesis and bystander effect. *Radiat. Environ Biophys.*
    46:383--394, 2007.

6.  Khokhryakov, V.F.; Kellerer, A.M.; Kreisheimer, M.; Romanov, S.A\...
    Lung Cancer in Nuclear Workers of Mayak. A Comparison of Numerical
    Procedures. *Radiat. Environ. Biophys.* 37:11--17; 1998.

7.  Khokhryakov, V.; Suslova, K.; Aladova, E.; Vasilenko, E.; Miller,
    S.C.; Slaughter, D.M.; Krahenbuhl, M.P. Development of an improved
    dosimetry system for the workers at the Mayak Production
    Association. *Health Phys*. 79:72--76; 2000.

8.  Khokhryakov, V.; Suslova, K.; Romanov, S.; Vostrotin, V. Pulmonary
    Clearance of Industrial Plutonium Compounds in remote Period after
    the Beginning of Inhalation. *Medical Radiology and Radiation
    Protection* 2:28--34; 2000.

9.  Khokhryakov, V.F.; Suslova, K.G.; Vostrotin, V.V.; Romanov, S.A.;
    Menshikh, Z.S.; Kudryavtseva, T.I.; Miller, S.C.; Krahenbuhl, M.P.;
    Filipy, R.E. The development of the plutonium lung clearance model
    for exposure estimation of the Mayak PA, nuclear plant workers.
    *Health Physics* 82:425--431; 2002.

10. Khokhryakov, V.F.; Chernikov, V.I.; Efimov, A.E. The use of
    scintillation body counter for monitoring of actinide accumulation
    among Mayak PA personnel. *Radiation Safety* (Special issue) 64--70,
    2003 (article in Russian).

11. Khokhryakov, V.F.; Kudryavtseva ,T.I.; Schadilov, A.E.; Shalaginov,
    A.I. Successful DTPA therapy in the case of 239Pu penetration via
    injured skin exposed to nitric acid. *Radiat. Prot. Dosim.*
    105:499--502; 2003.

12. Khokhryakov, V.F.; Vasilenko, E.K. Dosimetry register of Mayak PA
    personnel -- one of the major world information sources for solution
    of fundamental radiation safety problems. *Radiation Safety
    Problems* (Special Issue) 36--40; 2003 (article in Russian).

13. Khokhryakov, V.F. "Doses-1999, 2000" are serial improvements of
    plutonium dosimetry for Mayak PA workers. *Radiation Safety
    Problems* 1:71-- 82; 2004 (article in Russian).

14. Khokhryakov, V.F.; Suslova, K.G.; Kudravtseva, T.I.; Schadilov,
    A.E.; Vostrotin, V.V.; Lagounova, N.Y.; Barabanshchikova, A.Y.
    Precision of equations for systemic Pu excretion based on new data
    on nuclide removing with urine and feces at late times after
    inhalation. *Medical Radiology and Radiation Safety* 4:12--20; 2004
    (article in Russian).

15. Khokhryakov, V.F.; Suslova, K.G.; Kudryavtseva, T.I.; Schadilov,
    A.E.; Vostrotin, V.V.; Lagounova, N.Yu.; Barabanshchikova, A.Yu.
    Relative role of plutonium excretion with urine and feces from the
    human body. *Health Physics* 86:523--527; 2004.

16. Khokhryakov, V.F.; Suslova, K.G.; Vostrotin, V.V.; Romanov, S.A.;
    Eckerman, K.F.; Krahenbuhl, M.P.; Miller, S.C. Adaptation of the
    ICRP Publication 66 respiratory tract model to data on plutonium
    biokinetics for Mayak workers. *Health Phys*. 88:125--132; 2005.

17. Khokhryakov, V.F. Graphical method for assessment of doses and level
    accumulation based on urine excretion data. *Medical Radiology and
    Radiation Safety* 5:5--14; 2005 (in Russian).

18. Khokhryakov, V.F.; Khokhryakov, V.F.; Suslova, K.G.; Efimov, A.V.;
    Vostrotin, V.V., Schadilov, A.E. Status and prospects of internal
    dosimetry for the Mayak nuclear workers. *Int. J. of Low Radiation*
    2:219--235; 2006.

19. Khokhryakov, V.F, ; Khokhryakov, V.V. ; Suslova, K.G.; Vostrotin,
    V.V. ; Schadilov, A.E.; Sokolova, A.B.; Efimov, A.V. ; Krahenbuhl,
    M.P.; Miller, S.C.; Eckerman, K.F.; Leggett, R.W.. Progress in
    plutonium dosimetry development at Mayak PA. *Radiation Safety
    Problems* 1:58--79; 2006 (article in Russian).

20. Khokhryakov, V.F.; Khokhryakov, V.V. Physical-chemical mechanisms of
    dissolution of aerosols containing Pu dioxide. *Radiation Safety
    Issues* 3:47-59; 2008 (in Russian).

21. Khokhryakov, V.V.; Efimov, A.V. Experience in application of whole
    body counting technique to control 241Am body burden in the Mayak PA
    workers. *Radiation Safety Issue* 1:57--70; 2004 (article in
    Russian).

22. Khokhryakov, V.V.; Lagunova, N.Yu.; Sypko, S.A.; Rumyantseva, E.Yu.
    Investigation on effects of the dispersed composition of industrial
    aerosols on plutonium dialysis kinetics. *Siberian Medical Journal*
    2:99--104; 2005 (in Russian).

23. Khokhryakov, V.V.; Efimov, A.V. Americium-241 as the factor of
    internal exposure to Mayak PA workers. *Radiation Safety Problems*,
    1: 94--104; 2006 (article in Russian).

24. Khokhryakov, V.V, ; Khokhryakov, V.F. ; Suslova, K.G.; Sokolova,
    A.B. Time history analysis for isotopic composition of actinides
    inhaled by Mayak PA workers during 1949--2000. *Radiation Safety
    Journal* 3:58--65; 2007 (article in Russian)

25. Krahenbuhl, M.P.; Slaughter, D.M.; Wilde, J.L.; Bess, J.D.; Miller,
    S.C.; Khokhryakov, V.K.; Suslova, K.G.; Vostrotin, V.V.; Romanov,
    S.A.; Menshikh, Z.S.; Kudryavtseva, T.I. The historical and current
    application of the FIB-1 model to assess organ dose from plutonium
    intakes in Mayak workers. *Health Phys.* 82:445--45; 2002.

26. Krahenbuhl, M.P.; Bess, J.D.; Wilde, J.L.; Vostrotin, V.V.; Suslova,
    K.G.; Khokhryakov, V.F.; Slaughter, D.M.; Miller, S.C. Uncertainties
    analysis of doses resulting from chronic inhalation of plutonium at
    the Mayak Production Association. *Health Phys.* 89:33--45; 2005.

27. Kreisheimer, M.E.; Sokolnikov, M.E.; Koshurnikova, N.A.;
    Khokhryakov, V.F.; Romanov, S.A.; Shilnikova, N.S.; Okatenko, P.V.;
    Nekolla, E.A.; Kellerer, A.M. Lung cancer mortality among nuclear
    workers of the Mayak facilities in the former Soviet Union. *Radiat.
    Environ. Biophys*. 42:120--135; 2003.

28. Kudryavtseva, T.I.; Sokolova, A.B. Macrodistribution of Pu
    industrial compounds in human lung. *Radiation Safety Problems*
    3:41--48; 2005 (in Russian).

29. Leggett, R.W. Reliability of the ICRP's dose coefficients for
    members of the public. III. Plutonium as a case study of
    uncertainties in the systemic biokinetics of radionuclides.
    *Radiation Protection Dosimetry* 106:103--120; 2003.

30. Leggett, R.W.; Eckerman, K.F.; Khokhryakov, V.F.; Suslova, K.G.;
    Krahenbuhl, M.P.; Miller, S.C. Mayak worker study: An improved
    biokinetic model for reconstructing doses from internally deposited
    plutonium. *Radiat. Res.* 164:111--122; 2005.

31. Levkina E.V.; Romanov, S.A.; Miller, S.C.; Krahenbuhl, M.P.;
    Belosokhov, M.V. Quantitative plutonium microdistribution in bone
    tissue of vertebra from occupationally exposed worker. *Radiat.
    Biol. Radioecol.* 48:356-363; 2008 (in Russian).

32. Miller, S.C. Radionuclide-induced skeletal cancers. *J. Musculoskel.
    Neuron. Interact.* 2:552--553; 2002.

33. Miller, S.C.; Lloyd, R.D.; Bruenger, F.W.; Krahenbuhl, M.P.; Polig,
    E.; Romanov, S.A. Comparisons of the skeletal locations of putative
    plutonium-induced osteosarcomas in humans with those in Beagle dogs
    and with naturally-occurring tumors in both species. *Radiation
    Research* 160:517--523; 2003.

34. Okladnikova, N.D.; Khokhryakov, V.V.; Shevkunov, V.A.; Pesternikova,
    V.C. 239Pu: clinico-cytogenetic description of high-incorporation
    case. (24 years of observations). *Radiation Biology and
    Radioecology* 44:415--419; 2004 (article in Russian).

35. Okladnikova, N.D.; Scott, B.R.; Tokarskaya, Z.B.; Zhuntova, G.V.;
    Khokhryakov, V.F.; Syrchicov, V.A.; Grigoryeva, E.S. Chromosomal
    aberrations in lymphocytes of peripheral blood among Mayak facility
    workers who inhaled insoluble forms of 239Pu. *Radiat. Prot.
    Dosimetry* 113:3--13, 2005.

36. Romanov, S.A.; Vasilenko, E.K.; Khokhryakov, V.F.; Jacob, P. Studies
    on the Mayak nuclear workers: dosimetry. *Radiat. Environ. Biophys.*
    41:23--28, 2002.

37. Romanov, S.A,; Guilmette, R.A.; Khokhryakov, V.F.; Phipps, A.;
    Aladova, E.E.; Bertelli, L.; Birchall, A.; Eckerman, K.F.;
    Khokhryakov, V.V.; Krahenbuhl, M.P.; Leggett, R.W.; Little, T.T.;
    Miller, G.; Miller, S.C.; Riddell, A.; Suslova, K.G.;
    Vostrotin, V.V.; Zaytseva, Y.V. Comparison of dose estimation from
    occupational exposure to ^239^Pu using different modeling
    approaches. *Radiat. Prot. Dosim.* 127:486--490; 2007.

38. Schadilov, A.E.; Khokhryakov, V.F.; Kudravtseva, T.I.; Vostrotin,
    V.V. "DTPA effects on plutonium excretion from human body".
    *Siberian Medical Journal* 2:128--132; 2005 (in Russian).

39. Smetanin, M.Yu.; Vasilenko, E.K.; Lyubarskaya, I.V.; Knyazev, V.A.;
    Gorelov, M.V.; Scherpelz, R.I.; Fix, J.J. Calculation Experimental
    Studies of Energy and Angular Response of the Film Dosimeters used
    at the Mayak PA. *Radiation Safety Problems* 4:46--59; 2006 (*in
    Russian*).

40. [Smetanin,
    M](http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Smetanin M"%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus);
    [Vasilenko,
    E.K](http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Vasilenko EK"%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus).,
    [Lyubarskaya,
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    [Knyazev,
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    [Gorelov,
    M](http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Gorelov M"%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus).;
    [Scherpelz,
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    [Fix,
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    Mayak film dosimeter response studies, part II: response models.
    [*Health Phys.*](javascript:AL_get(this, 'jour', 'Health Phys.');)
    93:231--238, 2007.

41. [Smetanin
    M](http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Smetanin M"%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus),
    [Vasilenko
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    [Scherpelz
    RI](http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Scherpelz RI"%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus).
    Mayak film dosimeter response studies, part iii: application to
    worker dose assessment. [*Health
    Phys.*](javascript:AL_get(this, 'jour', 'Health Phys.');)
    93:239--244, 2007.

42. Sokolnikov, M.E.; Khokhryakov, V.F.; Vasilenko, E.K.; Koshurnikova,
    N.A. Risk of lung cancer development in the personnel exposed to
    internal radiation as a result of incorporated Pu. *Siberian Medical
    Journal* 5:31--36; 2003 (in Russian).

43. Suslova, K.; Khokhryakov, V.; Tokarskaya, Z.; Kudryavtseva, T.;
    Nifatov, A. Distribution of Plutonium in Organs of Extrapulmonary
    Pool in Remote Periods after the Beginning of Inhalation in Workers
    of Radiochemical Plant. *Medical Radiology and Radiation Protection*
    1:17--25; 2000.

44. Suslova, K.G.; Khokhryakov, V.F.; Tokarskaya, Z.B.; Nifatov, A.P.;
    Krahenbuhl, M.P.; Miller, S.C. Extrapulmonary organ distribution of
    plutonium in healthy workers exposed by chronic inhalation at the
    Mayak Production Association. *Health Physics* 82:432--444; 2002.

45. Suslova, K.G.; Khokhryakov, V.F.; Tokarskaya, Z.B.; Nifatov, A. P.;
    Sokolova, A.B; Miller, S.C.; Krahenbuhl, M.P. The effect of state of
    health on organ distribution and excretion of systemic plutonium in
    the Mayak workers. *Radiation Protection Dosimetry* 105:229--233;
    2003.

46. Suslova, K.G.; Khokhryakov, V.F.; Nifatov, A.P.; Sokolova, A.B.
    Smoking and Lung Diseases as the Modifying Factors of Plutonium
    Distribution in the Respiratory Tract at the Late Times of Clearance
    in Workers of the Radiochemical Plant. *Medical Radiology and
    Nuclear Safety* 3:10--21; 2006 (in Russian).

47. Suslova, K.G.; Khokhryakov, V.F.; Tokarskaya, Z.B.; Nifatov, A. P.;
    Sokolova, A.B; Miller, S.C. and Krahenbuhl, M.P. Modifying effects
    of health status, physiological, and dosimetric factors on
    extrapulmonary organ distribution and excretion of inhaled plutonium
    in workers at the Mayak Production Association. *Health Physics*
    90:299--311; 2006.

48. [Vasilenko
    EK](http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Vasilenko EK"%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus),
    [Knyazev
    V](http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Knyazev V"%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus),
    [Gorelov
    M](http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Gorelov M"%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus),
    [Smetanin
    M](http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Smetanin M"%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus),
    [Scherpelz
    RI](http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Scherpelz RI"%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus),
    [Fix
    JJ](http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Fix JJ"%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus).
    Mayak film dosimeter response studies, part I: measurements.
    [*Health Phys.*](javascript:AL_get(this, 'jour', 'Health Phys.');)
    93:220--230; 2007.

49. Vasilenko, E.K., Khokhryakov, V.F, Miller, S.C., Fix, J.J.,
    Eckerman, K., Choe, D.O., Gorelov, M., Khokhryakov, V., Knyazev, V.,
    Krahenbuhl, M.P., Scherpelz, R.I., Smetanin, M., Suslova, K.,
    Vostrotin. Mayak worker dosimetry study: An overview. *Health
    Physics* 93:190--206; 2007.

50. Vasilenko, E.K. Smetanin, M.Y., Miller, S.C. Slaughter, M., Jacob,
    P., Feherbaher, G. Approach to retrospective reconstruction of the
    photon exposure spectra distribution at technological sites of the
    Mayak Production Association. *Radiation Safety Problems* (Russian
    Federal Ministry of Atomic Energy) 3:42--50; 2000 (in Russian).

# 

# Project 2.5: Improved Plutonium Dose Assessment Methods for Mayak Workers (11)

1.  Guilmette, R.A.; Romanov, S.A.; Hahn, F.F.; Nifatov, A.P.;
    Muksinova, K.N.; Zaytseva, Y.V. Assessing the Uniformity of
    Plutonium Alpha Radiation Dose in Human Lung: The Mayak Experience.
    *Radiation Protection Dosimetry* 99:457*--*461; 2002.

2.  Hahn, F.F.; Romanov, S.A.; Guilmette, R.A.; Nifatov, A.P.; Zaytseva,
    Y.; Diel, J.H.; Allen, S.W.; Lyovkina, Y.V. Distribution of
    Plutonium in Particles in the Lungs of Mayak Workers. *Radiat.
    Protect. Dosim.* 105:81*--*84; 2003.

3.  Hahn, F.F.; Romanov, S.A.; Guilmette, R.A.; Nifatov, A.P.; Diel,
    J.A.; Zaytseva, Y.V.  Plutonium Microdistribution in the Lung of
    Mayak Workers. *Radiat. Res.* 161:568*--*581; 2004.

4.  Miller, G.; Bertelli, L.; Guilmette, R. IMPDOS (improved dosimetry
    and risk assessment for plutonium-induced diseases): internal
    dosimetry software tools developed for the Mayak worker study.
    *Radiat. Prot. Dosim.* 131:308*--*315, 2008.

5.  Miller, G.; Guilmette, R.; Bertelli, L.; Waters, R.; Romanov, S.A.;
    Zaytseva, Y.V. Uncertainties in internal doses calculated for Mayak
    workers -- a study of 63 cases. *Radiat. Prot. Dosim.*
    131:316*--*330, 2008.

6.  Miller, G. Variability and uncertainty in biokinetics model
    parameters -- the discrete empirical Bayes approximation. *Radiat.
    Prot. Dosim.* 131:394*--*398, 2008.

7.  Romanov, S.A.; Hahn, F.F.; Guilmette, R.A.; Nifatov, A.P.;
    Muksinova, K. N.; Zaytseva, Y.V. Using a Microdosimetric Approach to
    Improve Dosimetry of Lung Exposure to Internally Deposited
    Plutonium. *Medical Radiology and Radiation Safety.* 6:58*--*65;
    2001(article in Russian).

8.  Romanov, S.A.; Guilmette, R.A.; Hahn, F.F.; Nifatov, A.P.; Zaytseva,
    Y.V.; Lyovkina, Y.V. Improved Lung Dosimetry Using Plutonium
    Microdistribution Studies. *Radiat. Protect. Dosim*. 105:85*--*90;
    2003.

9.  Romanov, S.A.; Vasilenko, E.K.; Khokhryakov, V.F.; Jacob, P. Studies
    on the Mayak Nuclear Workers: Dosimetry. *Radiat. Environ. Biophys.*
    41:23--28; 2002.

10. Romanov, S.A.; Zaytseva, Y.V. Dosimetry of Internal Exposure of
    Respiratory Tract to Incorporated Plutonium. *Int. J. Low Radiation*
    2:257--262; 2006.

11. Romanov, S.A.; Zaytseva, Y.V.; Nifatov, A.P.; Lyovkina, Y.V.; Hahn,
    F.F.; Guilmette, R.A. Microdistribution of Plutonium-239 in the
    Lungs. *Siberian Medical Journal* 18:112--118; 2003 (article in
    Russian).

# Project 2.6: Molecular Markers of Lung Cancer in Mayak Workers (4)

1.  Belinsky, S.A.; Klinge, D.M.; Liechty, K.C.; March, T.H.; Kang, T.;
    Gilliland, F.D.; Sotnic, N.; Adamova, G.; Rusinova, G.; Telnov, V.
    Plutonium targets the p16 gene for inactivation by promoter
    hypermethylation in human lung adenocarcinoma. *Carcinogenesis*
    25:1063--1067; 2004.

2.  Lyon, C. M.; Klinge, D.M.; Liechty, K.C.; Gentry, F.D.; March, T.H.;
    Kang, T.; Gilliland, F.D.; Adamova, G.; Rusinova, G.; Telnov, V.;
    Belinsky, S.A. Radiation induced lung adenocarcinoma is associated
    with increased frequency of genes inactivated by promoter
    hypermethylation. *Radiation Res.* 168:409--414; 2007.

3.  Telnov, V.I.; Rusinova, G.G.; Adamova, G.V.; Belinsky, S.A.;
    Crowell, R.E.; Nikula, K.J. Molecular-epidemiological study of lung
    cancer in workers of atomic industry. *Medical Radiology and
    Radiation safety* 46:94*--*97; 2001 (in Russian).

4.  Telnov, V.I.; Belinsky, S.A.; Rusinova, G.G.; Crowell, R.E.; Sotnic,
    N.V.; Adamova, G.V. Molecular markers of lung cancer in atomic
    industry workers. *Radiation Safety Problems* 4:36*--*41; 2002 (in
    Russian).

# Project 2.7: Radiation Biomarkers (5)

1.  Brenner, D.J.; Okladnikova, N.; Hande, P.; Burak, L.; Geard, C.R.;
    Azizova, T. Biomarkers Specific to Densely Ionizing (High-LET)
    Radiations. *Radiat. Protec. Dosim.* 97:69*--*73; 2001.

2.  Brenner, D.J. Comments on "Chromosome intrachanges and interchanges
    detected by multicolor banding in lymphocytes: Searching for
    clastogen signatures in the human genome."   *Radiat. Res.* 162:600;
    2004.

3.  Hande, M.P.; Azizova, T.V.; Geard, C.R.; Burak, L.E.; Mitchell,
    C.R.; Khokhryakov, V.F.; Vasilenko, E.K.; Brenner, D.J. Past
    exposure to densely ionizing radiation leaves a unique permanent
    signature in the genome. *Am. J. Hum. Genet.* 72:1162*--*70; 2003.

4.  Hande, M.P.; Azizova, T.V.; Burak, L.E.; Khokhryakov, V.F.; Geard,
    C.R.; Brenner, D.J. Complex Chromosome Aberrations Persist in
    Individuals Many Years after Occupational Exposure to
    Densely-Ionizing Radiation: An mFISH Study. *Genes, Chromosomes,
    Cancer* 44:1--9 (2005).

5.  Mitchell, C.R.; Azizova, T.V.; Hande, P., Burak, L.E.; Tsakok, J.M.;
    Khokhryakov, V.F.; Geard, C.R.; Brenner, D.J. Stable
    intra-chromosomal biomarkers of past exposure to densely-ionizing
    radiation in several chromosomes of exposed individuals. *Radiat.
    Res.* 162:600; 2004.

# Project 2.8: Mayak Worker Tissue Repository (12)

1.  Akleyev, B.; Grosche, B.; Gusev, V.; Kiselev, M.; Kisselev, B.;
    Kolyado, S.; Romanov, S.; Shoikhet, Y.; Neta, R. Developing
    additional resources. *Radiation and Environmental Biophysics*
    41:13*--*18; 2002.

2.  Beslepkin, V.G.; Antipova, V.N.; Belskaya, I.I.; Gulyaeva, N.A.;
    Zakharova, M.L.; Yezhova, A.V.; Lomaeva, M.G.; Fomenko, L.A.;
    Gaziev, A.I. The analysis of changes in the peripheral blood genome
    of people with prolonged radiation exposure, in *Achievements and
    problems of genetics, selection and biotechnology*, Kiev: Logos
    1:406*--*410; 2008 (in Russian).

3.  Drugova, E.D. Serum TNFa and its receptors concentration in
    professionals in long term after prolonged exposure to radiation.
    *Radiation Biology Radioecology* 47:696*--*700; 2007 (in Russian).

4.  Gaziev, A.I.; Gulyaeva, N.A.; Belskaya, I.I.; Muksinova, K.N.;
    Zakharova, M.L.; Antipova, V.N.; Beslepkin, V.G. The use of
    temperature gradient gel electrophoresis to reveal mutations in
    peripheral blood mitochondrial DNA. *Radiation Biology Radioecology*
    48:133*--*138, 2008 (in Russian).

5.  Kirillova, E.N.; Muksinova, K.N.; Ezhova, A.V.; Sokolova, S.N.
    Establishment of human immortalized b-lymphocytes bank: Prospects of
    application. *Immunology* 25:196*--*197; 2004.

6.  Kirillova, E.N.; Muksinova, K.N.; Drozdova, U.V.; Drugova, E.D.;
    Uryadnitskaya, T.I. State of effector and regulator parts of
    immunity systems of Mayak workers exposed to prolonged radiation in
    long term. In *Actual issues of medical and social rehabilitation of
    citizens exposed to radiation*. Tomsk, 61*--*64, 2008.

7.  Muksinova K.N.; Neta R.; Kirillova E.N.; Revina V.S.; Sokolova,
    S.N.; Kreslov, V.V.; Suslova, K.G.; Zacharova, M.L.; Nifatov, A.P.;
    Uryadnitskaya, T.I.; Drugova, E.D.; Rybkina, V.L. Establishment of
    Russian Human Radiobiology Tissue Repository. *Medical Radiology and
    Radiation Safety* 46:98--106; 2001.

8.  Muksinova, K.N.; Neta, R.; Kirillova, E.N..; Sokolova, S.N.;
    Zakharova, M.L.; Revina, V.S.; Drougova, E.D.; Rybkina, V.L.;
    Uryadnitskaya, T.I.; Yezhova, A.V. Biological material repositorium
    of personnel of the first atomic enterprise of Russia. *Siberian
    Medical Journal* 18:84*--*89; 2003 (in Russian).

9.  Muksinova, K.N.; Revina, V.S; Kirillova, E.N; Zakharova, M.L.;
    Drugova, E.D.; Neta, R. Radiobiological characteristics of the tumor
    tissue bank of first Russian nuclear weapon facility professionals.
    *Medical Radiology and Radiation Safety* 51:44--51; 2006.

10. Muksinova K.; Kirillova, E.; Zakharova, M.; Revina, V.; Neta R.
    Bio-specimens Repository from Mayak workers exposed to protracted
    radiation. *Health Physics* 90:263--265; 2006.

11. Neta, R. The promise of molecular epidemiology in defining the
    association between radiation and cancer. *Health Physics*
    79:77*--*84; 2000.

12. Russell, J.J.; Muksinova, K.N.; Kathren, R.L.   Establishment of a
    Repository containing tissues of organs of deceased workers of Mayak
    Industrial association exposed to actinide elements.  *Health
    Physics* 76 (6) Suppl. 152--153; 1999.

>  

# Project 2.9: Database Integration (0)

> None.