Critical Technology Assessment of

Biotechnology in U.S. Industry

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> **SURVEY QUESTIONS FOR INDUSTRY**

**Office of Strategic Industries and Economic Security**

**Bureau of Industry and Security**

> **U.S. Department of Commerce**

**and**

**Office of Technology Policy**

**Technology Administration**

**U.S. Department of Commerce**

**July 2002**

Ref \# B-1 OMB Control \# 0694-0119

Expiration Date: 10/31/2002

The U.S. Department of Commerce, Bureau of Industry and Security (BIS),
Office of Strategic Industries and Economic Security, and the Technology
Administration, Office of Technology Policy are conducting an assessment
of Biotechnology in U.S. Industry. The goals of this assessment are to
analyze the economic health and competitiveness of companies that are
involved in biotechnology research or production, and to better
characterize current and developing commercial and national security
related products/processes. Your timely and complete response will
assist the participating organizations in their efforts to perform a
comprehensive, first-time analysis of this critical area.

This report is required by law (50 U.S.C. App. Sec. 2155). Failure to
report can result in a maximum fine of \$10,000 or imprisonment up to
one year, or both. Information furnished herewith is deemed confidential
and will not be published or disclosed except in accordance with Section
705 of the Defense Production Act of 1950, as amended (50 U.S.C. App.
Sec. 2155). Section 2061 et. seq. prohibits the publication or
disclosure of this information unless the President determines that its
withholding is contrary to the national defense. Information will not be
shared with any non-government entity, other than in aggregate form, and
the information will be protected pursuant to the appropriate exemptions
from disclosure under the Freedom of Information Act (FOIA), should it
be the subject of a FOIA request.

Notwithstanding any other provision of law, no person is required to
respond to nor shall a person be subject to a penalty for failure to
comply with a collection of information subject to the requirements of
the Paperwork Reduction Act unless that collection of information
displays a currently valid OMB Control Number.

Public reporting burden for this collection of information is estimated
to average five hours per response, including the time for reviewing
instructions, searching existing data sources, gathering and maintaining
the data needed, and completing and reviewing the collection of
information. Send comments regarding this burden estimate or any other
aspect of this collection of information, including suggestions for
reducing this burden, to U.S. Department of Commerce, BIS Reports
Clearance Officer, Room 6883, Bureau of Industry and Security,
Washington, DC 20230, and to the Office of Management and Budget,
Paperwork Reduction Project ( OMB Control Number 0694-0119), Washington,
DC 20503.

+-----------------------------------------------------------------------+
| #### DEFINITIONS                                                      |
+-----------------------------------------------------------------------+

**[Biotechnology]{.underline}**: The application of molecular and
cellular processes to solve problems, conduct research, and create goods
and services. It includes a diverse collection of technologies that
manipulate cellular, sub-cellular, or molecular components in living
things to make products or discover new knowledge about the molecular
and genetic basis of life, or to modify plants, animals and
micro-organisms to carry desired traits. Such technologies include, but
are not limited to: genetic engineering (e.g., recombinant DNA, gene
therapy, cloning, antisense); hybridoma technology (to produce
monoclonal antibodies); polymerase chain reaction or PCR amplification;
gene mapping; DNA sequencing; restriction fragment length polymorphism
(RFLP) analysis; and protein engineering.

**[Development]{.underline}**: The design, development, simulation, or
experimental testing of prototype or experimental hardware or systems to
validate technological feasibility or concept of operation, to reduce
technological risk and to provide test systems prior to production
approval.

**[Establishment]{.underline}**: A facility in which biotechnology is
developed or utilized, or where biotechnology-related research and
development takes place. Includes auxiliary facilities operated in
conjunction with (whether or not physically separated from) such
facilities.

**[Firm]{.underline}**: An individual proprietorship, partnership,
corporation (including any subsidiary corporation in which more than 50
percent of the outstanding voting stock is owned), cooperative, joint
venture, consortium, association, business trust, trustees in
bankruptcy, or receivers under decree of any court owning or controlling
one or more establishments, as defined above.

**[Manufacturing Products]{.underline}**: The output from manufacturing
and production activities or associated with the concurrent development
and maturation of the product design.

**[Research, Basic & Applied]{.underline}**: Includes activities carried
on by persons trained, either formally or by experience, in the biology
or physical sciences including related engineering and software
development, if the purpose of such activity is to do one or more of the
following:

**[Basic Research]{.underline}**: Systematic study directed toward
greater knowledge or understanding of the fundamental aspects of
phenomena and of observable facts without specific applications towards
processes or products in mind.

**[Applied Research]{.underline}**: Systematic study to gain knowledge
or understanding necessary to determine the means by which a recognized
and specific need may be met. It is a systematic application of
knowledge toward the production of useful materials, devices and systems
or methods, including design, development, and improvement of prototypes
and new processes to meet specific requirements.

[**United States**:]{.underline} Includes the fifty States, Puerto Rico,
the District of Columbia, the Virgin Islands, American Samoa, and the
Trust Territories of the Pacific Islands.

**Who must complete this survey**: Please complete this questionnaire if
your company performs biotechnology research and development, uses a
biotechnology process in manufacturing, or produces research tools. To
determine if your firm is exempt from participating, please see page iv.

This survey has six sections as follows:

  ----------------------- ----------------------- -----------------------
  **PART I** -- Firm      **PART II** --          **PART III** -- Human
  Identification &        Biotechnology           Resources
  Exemption               Activities              

  **PART IV** --          **PART V** -- Future    **PART VI** -
  Financial & Economic    Projections & Market    Certification
  Conditions              Conditions              
  ----------------------- ----------------------- -----------------------

1.  **Multiple Business Units:** You must complete this survey for all
    of your U.S. biotechnology operations. You may combine all of the
    data from individual business units into one response, or submit
    separate surveys for each unit. When responding, please indicate how
    many surveys we should expect to receive from your firm.

2.  **Estimates:** It is not our desire to impose any unreasonable
    burden on any respondent. If information requested is not available
    from your records in exactly the form indicated, furnish the most
    accurate estimates you are able to provide and designate these
    figures as such with the letter "E" following the estimate figure.
    If an item does not apply to your firm, please designate with the
    letters "N/A."

3.  **Small Businesses**: Companies with fifty or fewer employees,
    please only provide one year of data as requested for questions 24,
    25, 28, 29, 30 and 31,

3- **Questions** related to this survey should be directed to: 

Robert Nichol, Senior Trade & Industry Analyst, (202) 482-1269,
<RNichol@bis.doc.gov>

Mark Crawford, Senior Trade & Industry Analyst, (202) 482-8239,
<Mcrawfor@bis.doc.gov>

David Villarreal, Trade & Industry Analyst, (202) 482-7418,
<DVillarr@bis.doc.gov>

> Fax: (202) 482-5650

4.  If you are interested in downloading additional copies of the
    survey, please visit our Web site at:
    <http://www.bis.doc.gov/OSIES/DefMarketResearchRpts/>

5.  **Before returning your completed survey**, be sure to: 1) sign the
    certification on page 17; 2) identify the name and phone number of
    the person(s) responsible for the completion and submission of this
    survey; and 3) make a copy of the completed survey for your records.

**Please return the completed survey within 45 days of receipt to:**

> Mr. Brad Botwin, Division Director
>
> BIS/SIES, Room 3876 B-1
>
> U.S. Department of Commerce
>
> 14^th^ Street & Constitution Avenue, NW
>
> Washington, DC 20230

To determine whether your company is exempt from the requirement to
complete this survey, first review the biotechnology definition on page
ii. Second, if your company performs biotechnology research and
development, uses a biotechnology process in manufacturing, or produces
research tools, check the box of the major category from the list below
that most accurately describes your company's [primary]{.underline} (P)
application of biotechnology and check the box(s) of all applicable
[secondary]{.underline} (S) applications of biotechnology. Finally,
check the box(s) of subcategory(s) that most accurately describe your
company's activity. **If you checked any category (1-8), then your firm
is required to complete this survey.**

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+---+---+----------+---+---+-------------+-----------------------------------+
|   |   |          |   |   |             |                                   |
+---+---+----------+---+---+-------------+-----------------------------------+
|   |   |          |   |   | **1.1.**    | e.g., vaccines.                   |
|   |   |          |   |   | Prevention  |                                   |
+---+---+----------+---+---+-------------+-----------------------------------+
|   |   |          |   |   | **1.2.**    | e.g., gene tagging, biosensors or |
|   |   |          |   |   | Diagnostics | polymerase chain reaction         |
|   |   |          |   |   |             | amplification.                    |
+---+---+----------+---+---+-------------+-----------------------------------+
|   |   |          |   |   | **1.3.**    | e.g., biopharmaceuticals, gene    |
|   |   |          |   |   | T           | therapy.                          |
|   |   |          |   |   | herapeutics |                                   |
+---+---+----------+---+---+-------------+-----------------------------------+
|   |   | 2\.      | C |   |             |                                   |
|   |   | Animal   | r |   |             |                                   |
|   |   | health   | e |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | f |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | w |   |             |                                   |
|   |   |          | v |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | c |   |             |                                   |
|   |   |          | c |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | s |   |             |                                   |
|   |   |          | , |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | h |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | p |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | u |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | c |   |             |                                   |
|   |   |          | s |   |             |                                   |
|   |   |          | , |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | d |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | h |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | p |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | d |   |             |                                   |
|   |   |          | u |   |             |                                   |
|   |   |          | c |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | s |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | d |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | g |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | s |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | , |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | d |   |             |                                   |
|   |   |          | v |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | c |   |             |                                   |
|   |   |          | c |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | m |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | l |   |             |                                   |
|   |   |          | s |   |             |                                   |
|   |   |          | f |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | v |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | u |   |             |                                   |
|   |   |          | s |   |             |                                   |
|   |   |          | d |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | s |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | s |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | s |   |             |                                   |
|   |   |          | . |   |             |                                   |
+---+---+----------+---+---+-------------+-----------------------------------+
|   |   | 3\.      | U |   |             |                                   |
|   |   | Agri     | t |   |             |                                   |
|   |   | cultural | i |   |             |                                   |
|   |   | &        | l |   |             |                                   |
|   |   | aquac    | i |   |             |                                   |
|   |   | ultural/ | z |   |             |                                   |
|   |   | marine   | e |   |             |                                   |
|   |   |          | s |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | g |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | s |   |             |                                   |
|   |   |          | b |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | l |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | g |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | c |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | l |   |             |                                   |
|   |   |          | l |   |             |                                   |
|   |   |          | y |   |             |                                   |
|   |   |          | - |   |             |                                   |
|   |   |          | d |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | v |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | d |   |             |                                   |
|   |   |          | p |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | d |   |             |                                   |
|   |   |          | u |   |             |                                   |
|   |   |          | c |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | s |   |             |                                   |
|   |   |          | . |   |             |                                   |
+---+---+----------+---+---+-------------+-----------------------------------+
|   |   |          |   |   | **3.1.**    | Better or more useful plants,     |
|   |   |          |   |   | Seeds &     | crops or trees, and solutions to  |
|   |   |          |   |   | plants      | agricultural problems.            |
+---+---+----------+---+---+-------------+-----------------------------------+
|   |   |          |   |   | **3.2.**    | Better animal products, and       |
|   |   |          |   |   | Livestock   | solutions to livestock-related    |
|   |   |          |   |   |             | problems, excluding               |
|   |   |          |   |   |             | health-related.                   |
+---+---+----------+---+---+-------------+-----------------------------------+
|   |   |          |   |   | **3.3.**    | Better aquatic plant and animal   |
|   |   |          |   |   | Aquaculture | foods and byproducts.             |
+---+---+----------+---+---+-------------+-----------------------------------+
|   |   | 4\.      | C |   |             |                                   |
|   |   | Marine & | o |   |             |                                   |
|   |   | ter      | n |   |             |                                   |
|   |   | restrial | d |   |             |                                   |
|   |   | m        | u |   |             |                                   |
|   |   | icrobial | c |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | s |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | s |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | c |   |             |                                   |
|   |   |          | h |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | d |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | m |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | p |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | l |   |             |                                   |
|   |   |          | u |   |             |                                   |
|   |   |          | s |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | s |   |             |                                   |
|   |   |          | f |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | m |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | c |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | g |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | s |   |             |                                   |
|   |   |          | m |   |             |                                   |
|   |   |          | s |   |             |                                   |
|   |   |          | . |   |             |                                   |
+---+---+----------+---+---+-------------+-----------------------------------+
|   |   |          |   |   | **4.1.**    | Explores the capabilities of      |
|   |   |          |   |   | Marine      | marine microorganisms to develop  |
|   |   |          |   |   | microbial   | new classes of human vaccines,    |
|   |   |          |   |   |             | medicines, and other medical      |
|   |   |          |   |   |             | products, chemical products,      |
|   |   |          |   |   |             | enzymes, and industrial           |
|   |   |          |   |   |             | processes.                        |
+---+---+----------+---+---+-------------+-----------------------------------+
|   |   |          |   |   | **4.2.**    | Explores the capabilities of      |
|   |   |          |   |   | Terrestrial | terrestrial microorganisms such   |
|   |   |          |   |   | microbial   | as extremophiles from geysers and |
|   |   |          |   |   |             | volcanic vents.                   |
+---+---+----------+---+---+-------------+-----------------------------------+
|   |   | 5\.      | A |   |             |                                   |
|   |   | In       | p |   |             |                                   |
|   |   | dustrial | p |   |             |                                   |
|   |   | &        | l |   |             |                                   |
|   |   | Agri     | i |   |             |                                   |
|   |   | cultural | e |   |             |                                   |
|   |   | -derived | s |   |             |                                   |
|   |   | pr       | t |   |             |                                   |
|   |   | ocessing | h |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | c |   |             |                                   |
|   |   |          | h |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | q |   |             |                                   |
|   |   |          | u |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | s |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | f |   |             |                                   |
|   |   |          | m |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | d |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | m |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | l |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | c |   |             |                                   |
|   |   |          | u |   |             |                                   |
|   |   |          | l |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | b |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | l |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | g |   |             |                                   |
|   |   |          | y |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | m |   |             |                                   |
|   |   |          | p |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | v |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | f |   |             |                                   |
|   |   |          | f |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | c |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | c |   |             |                                   |
|   |   |          | y |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | d |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | d |   |             |                                   |
|   |   |          | u |   |             |                                   |
|   |   |          | c |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | v |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | m |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | l |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | m |   |             |                                   |
|   |   |          | p |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | c |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | s |   |             |                                   |
|   |   |          | . |   |             |                                   |
+---+---+----------+---+---+-------------+-----------------------------------+
|   |   |          |   |   | **5.1.**    | e.g., amino acids, enzymes.       |
|   |   |          |   |   | Specialty   |                                   |
|   |   |          |   |   | chemicals   |                                   |
+---+---+----------+---+---+-------------+-----------------------------------+
|   |   |          |   |   | **5.2.**    | e.g., grain processing,           |
|   |   |          |   |   | Food        | bioprocessing (e.g., using        |
|   |   |          |   |   | processing  | enzymes and bacteria culture),    |
|   |   |          |   |   |             | vitamins, and phytochemicals      |
|   |   |          |   |   |             | (e.g., neutraceuticals or         |
|   |   |          |   |   |             | functional foods).                |
+---+---+----------+---+---+-------------+-----------------------------------+
|   |   |          |   |   | **5.3.**    | e.g., commodity chemicals,        |
|   |   |          |   |   | Other       | chemical feed stocks, fuels,      |
|   |   |          |   |   | chemicals & | lubricants, textiles, biopulping, |
|   |   |          |   |   |             | biobleaching, paper, fuels,       |
|   |   |          |   |   | industrial  | starch and grain processing,      |
|   |   |          |   |   | activity    | flavors & fragrances, plastics.   |
+---+---+----------+---+---+-------------+-----------------------------------+
|   |   | 6\.      | U |   |             |                                   |
|   |   | Envir    | s |   |             |                                   |
|   |   | onmental | e |   |             |                                   |
|   |   | rem      | s |   |             |                                   |
|   |   | ediation | l |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | v |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | g |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | g |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | s |   |             |                                   |
|   |   |          | m |   |             |                                   |
|   |   |          | s |   |             |                                   |
|   |   |          | f |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | w |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | d |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | v |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | y |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | f |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | p |   |             |                                   |
|   |   |          | p |   |             |                                   |
|   |   |          | l |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | c |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | s |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | h |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | z |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | d |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | u |   |             |                                   |
|   |   |          | s |   |             |                                   |
|   |   |          | w |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | s |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | m |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | d |   |             |                                   |
|   |   |          | p |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | l |   |             |                                   |
|   |   |          | l |   |             |                                   |
|   |   |          | u |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | p |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | v |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | w |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | h |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | g |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | d |   |             |                                   |
|   |   |          | s |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | , |   |             |                                   |
|   |   |          | w |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | , |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | d |   |             |                                   |
|   |   |          | s |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | l |   |             |                                   |
|   |   |          | ( |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | . |   |             |                                   |
|   |   |          | g |   |             |                                   |
|   |   |          | . |   |             |                                   |
|   |   |          | , |   |             |                                   |
|   |   |          | b |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | m |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | d |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | , |   |             |                                   |
|   |   |          | p |   |             |                                   |
|   |   |          | h |   |             |                                   |
|   |   |          | y |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | m |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | d |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | , |   |             |                                   |
|   |   |          | b |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | f |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | l |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | ) |   |             |                                   |
|   |   |          | . |   |             |                                   |
+---+---+----------+---+---+-------------+-----------------------------------+
|   |   | 7\.      | U |   |             |                                   |
|   |   | Natural  | s |   |             |                                   |
|   |   | resource | e |   |             |                                   |
|   |   | recovery | s |   |             |                                   |
|   |   |          | l |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | v |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | g |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | g |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | s |   |             |                                   |
|   |   |          | m |   |             |                                   |
|   |   |          | s |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | f |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | c |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | l |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | h |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | c |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | v |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | y |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | x |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | c |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | f |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | g |   |             |                                   |
|   |   |          | y |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | m |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | l |   |             |                                   |
|   |   |          | s |   |             |                                   |
|   |   |          | ( |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | . |   |             |                                   |
|   |   |          | g |   |             |                                   |
|   |   |          | . |   |             |                                   |
|   |   |          | , |   |             |                                   |
|   |   |          | m |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | c |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | b |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | l |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | g |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | c |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | l |   |             |                                   |
|   |   |          | l |   |             |                                   |
|   |   |          | y |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | h |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | c |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | d |   |             |                                   |
|   |   |          | p |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | l |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | u |   |             |                                   |
|   |   |          | m |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | m |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | l |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | c |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | v |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | y |   |             |                                   |
|   |   |          | , |   |             |                                   |
|   |   |          | b |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | d |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | s |   |             |                                   |
|   |   |          | u |   |             |                                   |
|   |   |          | l |   |             |                                   |
|   |   |          | p |   |             |                                   |
|   |   |          | h |   |             |                                   |
|   |   |          | u |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | z |   |             |                                   |
|   |   |          | a |   |             |                                   |
|   |   |          | t |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | o |   |             |                                   |
|   |   |          | n |   |             |                                   |
|   |   |          | ) |   |             |                                   |
|   |   |          | . |   |             |                                   |
+---+---+----------+---+---+-------------+-----------------------------------+
|   |   | 8\.      | D |   |             |                                   |
|   |   | Other    | e |   |             |                                   |
|   |   |          | s |   |             |                                   |
|   |   |          | c |   |             |                                   |
|   |   |          | r |   |             |                                   |
|   |   |          | i |   |             |                                   |
|   |   |          | b |   |             |                                   |
|   |   |          | e |   |             |                                   |
|   |   |          | : |   |             |                                   |
+---+---+----------+---+---+-------------+-----------------------------------+
| * |   |          |   |   |             |                                   |
| * |   |          |   |   |             |                                   |
| I |   |          |   |   |             |                                   |
| f |   |          |   |   |             |                                   |
| y |   |          |   |   |             |                                   |
| o |   |          |   |   |             |                                   |
| u |   |          |   |   |             |                                   |
| r |   |          |   |   |             |                                   |
| f |   |          |   |   |             |                                   |
| i |   |          |   |   |             |                                   |
| r |   |          |   |   |             |                                   |
| m |   |          |   |   |             |                                   |
| d |   |          |   |   |             |                                   |
| o |   |          |   |   |             |                                   |
| e |   |          |   |   |             |                                   |
| s |   |          |   |   |             |                                   |
| n |   |          |   |   |             |                                   |
| o |   |          |   |   |             |                                   |
| t |   |          |   |   |             |                                   |
| p |   |          |   |   |             |                                   |
| e |   |          |   |   |             |                                   |
| r |   |          |   |   |             |                                   |
| f |   |          |   |   |             |                                   |
| o |   |          |   |   |             |                                   |
| r |   |          |   |   |             |                                   |
| m |   |          |   |   |             |                                   |
| b |   |          |   |   |             |                                   |
| i |   |          |   |   |             |                                   |
| o |   |          |   |   |             |                                   |
| t |   |          |   |   |             |                                   |
| e |   |          |   |   |             |                                   |
| c |   |          |   |   |             |                                   |
| h |   |          |   |   |             |                                   |
| n |   |          |   |   |             |                                   |
| o |   |          |   |   |             |                                   |
| l |   |          |   |   |             |                                   |
| o |   |          |   |   |             |                                   |
| g |   |          |   |   |             |                                   |
| y |   |          |   |   |             |                                   |
| r |   |          |   |   |             |                                   |
| e |   |          |   |   |             |                                   |
| s |   |          |   |   |             |                                   |
| e |   |          |   |   |             |                                   |
| a |   |          |   |   |             |                                   |
| r |   |          |   |   |             |                                   |
| c |   |          |   |   |             |                                   |
| h |   |          |   |   |             |                                   |
| a |   |          |   |   |             |                                   |
| n |   |          |   |   |             |                                   |
| d |   |          |   |   |             |                                   |
| d |   |          |   |   |             |                                   |
| e |   |          |   |   |             |                                   |
| v |   |          |   |   |             |                                   |
| e |   |          |   |   |             |                                   |
| l |   |          |   |   |             |                                   |
| o |   |          |   |   |             |                                   |
| p |   |          |   |   |             |                                   |
| m |   |          |   |   |             |                                   |
| e |   |          |   |   |             |                                   |
| n |   |          |   |   |             |                                   |
| t |   |          |   |   |             |                                   |
| , |   |          |   |   |             |                                   |
| u |   |          |   |   |             |                                   |
| s |   |          |   |   |             |                                   |
| e |   |          |   |   |             |                                   |
| a |   |          |   |   |             |                                   |
| b |   |          |   |   |             |                                   |
| i |   |          |   |   |             |                                   |
| o |   |          |   |   |             |                                   |
| t |   |          |   |   |             |                                   |
| e |   |          |   |   |             |                                   |
| c |   |          |   |   |             |                                   |
| h |   |          |   |   |             |                                   |
| n |   |          |   |   |             |                                   |
| o |   |          |   |   |             |                                   |
| l |   |          |   |   |             |                                   |
| o |   |          |   |   |             |                                   |
| g |   |          |   |   |             |                                   |
| y |   |          |   |   |             |                                   |
| p |   |          |   |   |             |                                   |
| r |   |          |   |   |             |                                   |
| o |   |          |   |   |             |                                   |
| c |   |          |   |   |             |                                   |
| e |   |          |   |   |             |                                   |
| s |   |          |   |   |             |                                   |
| s |   |          |   |   |             |                                   |
| i |   |          |   |   |             |                                   |
| n |   |          |   |   |             |                                   |
| m |   |          |   |   |             |                                   |
| a |   |          |   |   |             |                                   |
| n |   |          |   |   |             |                                   |
| u |   |          |   |   |             |                                   |
| f |   |          |   |   |             |                                   |
| a |   |          |   |   |             |                                   |
| c |   |          |   |   |             |                                   |
| t |   |          |   |   |             |                                   |
| u |   |          |   |   |             |                                   |
| r |   |          |   |   |             |                                   |
| i |   |          |   |   |             |                                   |
| n |   |          |   |   |             |                                   |
| g |   |          |   |   |             |                                   |
| , |   |          |   |   |             |                                   |
| o |   |          |   |   |             |                                   |
| r |   |          |   |   |             |                                   |
| p |   |          |   |   |             |                                   |
| r |   |          |   |   |             |                                   |
| o |   |          |   |   |             |                                   |
| d |   |          |   |   |             |                                   |
| u |   |          |   |   |             |                                   |
| c |   |          |   |   |             |                                   |
| e |   |          |   |   |             |                                   |
| r |   |          |   |   |             |                                   |
| e |   |          |   |   |             |                                   |
| s |   |          |   |   |             |                                   |
| e |   |          |   |   |             |                                   |
| a |   |          |   |   |             |                                   |
| r |   |          |   |   |             |                                   |
| c |   |          |   |   |             |                                   |
| h |   |          |   |   |             |                                   |
| t |   |          |   |   |             |                                   |
| o |   |          |   |   |             |                                   |
| o |   |          |   |   |             |                                   |
| l |   |          |   |   |             |                                   |
| s |   |          |   |   |             |                                   |
| r |   |          |   |   |             |                                   |
| e |   |          |   |   |             |                                   |
| l |   |          |   |   |             |                                   |
| a |   |          |   |   |             |                                   |
| t |   |          |   |   |             |                                   |
| e |   |          |   |   |             |                                   |
| d |   |          |   |   |             |                                   |
| t |   |          |   |   |             |                                   |
| o |   |          |   |   |             |                                   |
| t |   |          |   |   |             |                                   |
| h |   |          |   |   |             |                                   |
| e |   |          |   |   |             |                                   |
| s |   |          |   |   |             |                                   |
| e |   |          |   |   |             |                                   |
| a |   |          |   |   |             |                                   |
| r |   |          |   |   |             |                                   |
| e |   |          |   |   |             |                                   |
| a |   |          |   |   |             |                                   |
| s |   |          |   |   |             |                                   |
| ( |   |          |   |   |             |                                   |
| 1 |   |          |   |   |             |                                   |
| - |   |          |   |   |             |                                   |
| 8 |   |          |   |   |             |                                   |
| ) |   |          |   |   |             |                                   |
| , |   |          |   |   |             |                                   |
| s |   |          |   |   |             |                                   |
| e |   |          |   |   |             |                                   |
| l |   |          |   |   |             |                                   |
| e |   |          |   |   |             |                                   |
| c |   |          |   |   |             |                                   |
| t |   |          |   |   |             |                                   |
| c |   |          |   |   |             |                                   |
| a |   |          |   |   |             |                                   |
| t |   |          |   |   |             |                                   |
| e |   |          |   |   |             |                                   |
| g |   |          |   |   |             |                                   |
| o |   |          |   |   |             |                                   |
| r |   |          |   |   |             |                                   |
| y |   |          |   |   |             |                                   |
| 9 |   |          |   |   |             |                                   |
| ; |   |          |   |   |             |                                   |
| y |   |          |   |   |             |                                   |
| o |   |          |   |   |             |                                   |
| u |   |          |   |   |             |                                   |
| r |   |          |   |   |             |                                   |
| f |   |          |   |   |             |                                   |
| i |   |          |   |   |             |                                   |
| r |   |          |   |   |             |                                   |
| m |   |          |   |   |             |                                   |
| i |   |          |   |   |             |                                   |
| s |   |          |   |   |             |                                   |
| e |   |          |   |   |             |                                   |
| x |   |          |   |   |             |                                   |
| e |   |          |   |   |             |                                   |
| m |   |          |   |   |             |                                   |
| p |   |          |   |   |             |                                   |
| t |   |          |   |   |             |                                   |
| f |   |          |   |   |             |                                   |
| r |   |          |   |   |             |                                   |
| o |   |          |   |   |             |                                   |
| m |   |          |   |   |             |                                   |
| c |   |          |   |   |             |                                   |
| o |   |          |   |   |             |                                   |
| m |   |          |   |   |             |                                   |
| p |   |          |   |   |             |                                   |
| l |   |          |   |   |             |                                   |
| e |   |          |   |   |             |                                   |
| t |   |          |   |   |             |                                   |
| i |   |          |   |   |             |                                   |
| n |   |          |   |   |             |                                   |
| g |   |          |   |   |             |                                   |
| t |   |          |   |   |             |                                   |
| h |   |          |   |   |             |                                   |
| i |   |          |   |   |             |                                   |
| s |   |          |   |   |             |                                   |
| s |   |          |   |   |             |                                   |
| u |   |          |   |   |             |                                   |
| r |   |          |   |   |             |                                   |
| v |   |          |   |   |             |                                   |
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| y |   |          |   |   |             |                                   |
| . |   |          |   |   |             |                                   |
| P |   |          |   |   |             |                                   |
| l |   |          |   |   |             |                                   |
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| a |   |          |   |   |             |                                   |
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| o |   |          |   |   |             |                                   |
| m |   |          |   |   |             |                                   |
| p |   |          |   |   |             |                                   |
| l |   |          |   |   |             |                                   |
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| a |   |          |   |   |             |                                   |
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| ( |   |          |   |   |             |                                   |
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| a |   |          |   |   |             |                                   |
| g |   |          |   |   |             |                                   |
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| a |   |          |   |   |             |                                   |
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| d |   |          |   |   |             |                                   |
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| t |   |          |   |   |             |                                   |
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| y |   |          |   |   |             |                                   |
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| s |   |          |   |   |             |                                   |
| s |   |          |   |   |             |                                   |
| i |   |          |   |   |             |                                   |
| n |   |          |   |   |             |                                   |
| d |   |          |   |   |             |                                   |
| i |   |          |   |   |             |                                   |
| c |   |          |   |   |             |                                   |
| a |   |          |   |   |             |                                   |
| t |   |          |   |   |             |                                   |
| e |   |          |   |   |             |                                   |
| d |   |          |   |   |             |                                   |
| o |   |          |   |   |             |                                   |
| n |   |          |   |   |             |                                   |
| p |   |          |   |   |             |                                   |
| a |   |          |   |   |             |                                   |
| g |   |          |   |   |             |                                   |
| e |   |          |   |   |             |                                   |
| i |   |          |   |   |             |                                   |
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| i |   |          |   |   |             |                                   |
| . |   |          |   |   |             |                                   |
| * |   |          |   |   |             |                                   |
| * |   |          |   |   |             |                                   |
+---+---+----------+---+---+-------------+-----------------------------------+
|   |   | 9\. No   |   | T |             |                                   |
|   |   | Biote    |   | h |             |                                   |
|   |   | chnology |   | i |             |                                   |
|   |   |          |   | s |             |                                   |
|   |   |          |   | f |             |                                   |
|   |   |          |   | i |             |                                   |
|   |   |          |   | r |             |                                   |
|   |   |          |   | m |             |                                   |
|   |   |          |   | h |             |                                   |
|   |   |          |   | a |             |                                   |
|   |   |          |   | s |             |                                   |
|   |   |          |   | n |             |                                   |
|   |   |          |   | o |             |                                   |
|   |   |          |   | t |             |                                   |
|   |   |          |   | p |             |                                   |
|   |   |          |   | e |             |                                   |
|   |   |          |   | r |             |                                   |
|   |   |          |   | f |             |                                   |
|   |   |          |   | o |             |                                   |
|   |   |          |   | r |             |                                   |
|   |   |          |   | m |             |                                   |
|   |   |          |   | e |             |                                   |
|   |   |          |   | d |             |                                   |
|   |   |          |   | b |             |                                   |
|   |   |          |   | i |             |                                   |
|   |   |          |   | o |             |                                   |
|   |   |          |   | t |             |                                   |
|   |   |          |   | e |             |                                   |
|   |   |          |   | c |             |                                   |
|   |   |          |   | h |             |                                   |
|   |   |          |   | n |             |                                   |
|   |   |          |   | o |             |                                   |
|   |   |          |   | l |             |                                   |
|   |   |          |   | o |             |                                   |
|   |   |          |   | g |             |                                   |
|   |   |          |   | y |             |                                   |
|   |   |          |   | r |             |                                   |
|   |   |          |   | e |             |                                   |
|   |   |          |   | s |             |                                   |
|   |   |          |   | e |             |                                   |
|   |   |          |   | a |             |                                   |
|   |   |          |   | r |             |                                   |
|   |   |          |   | c |             |                                   |
|   |   |          |   | h |             |                                   |
|   |   |          |   | a |             |                                   |
|   |   |          |   | n |             |                                   |
|   |   |          |   | d |             |                                   |
|   |   |          |   | d |             |                                   |
|   |   |          |   | e |             |                                   |
|   |   |          |   | v |             |                                   |
|   |   |          |   | e |             |                                   |
|   |   |          |   | l |             |                                   |
|   |   |          |   | o |             |                                   |
|   |   |          |   | p |             |                                   |
|   |   |          |   | m |             |                                   |
|   |   |          |   | e |             |                                   |
|   |   |          |   | n |             |                                   |
|   |   |          |   | t |             |                                   |
|   |   |          |   | , |             |                                   |
|   |   |          |   | u |             |                                   |
|   |   |          |   | s |             |                                   |
|   |   |          |   | e |             |                                   |
|   |   |          |   | d |             |                                   |
|   |   |          |   | a |             |                                   |
|   |   |          |   | b |             |                                   |
|   |   |          |   | i |             |                                   |
|   |   |          |   | o |             |                                   |
|   |   |          |   | t |             |                                   |
|   |   |          |   | e |             |                                   |
|   |   |          |   | c |             |                                   |
|   |   |          |   | h |             |                                   |
|   |   |          |   | n |             |                                   |
|   |   |          |   | o |             |                                   |
|   |   |          |   | l |             |                                   |
|   |   |          |   | o |             |                                   |
|   |   |          |   | g |             |                                   |
|   |   |          |   | y |             |                                   |
|   |   |          |   | p |             |                                   |
|   |   |          |   | r |             |                                   |
|   |   |          |   | o |             |                                   |
|   |   |          |   | c |             |                                   |
|   |   |          |   | e |             |                                   |
|   |   |          |   | s |             |                                   |
|   |   |          |   | s |             |                                   |
|   |   |          |   | i |             |                                   |
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|   |   |          |   | a |             |                                   |
|   |   |          |   | n |             |                                   |
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|   |   |          |   | a |             |                                   |
|   |   |          |   | c |             |                                   |
|   |   |          |   | t |             |                                   |
|   |   |          |   | u |             |                                   |
|   |   |          |   | r |             |                                   |
|   |   |          |   | i |             |                                   |
|   |   |          |   | n |             |                                   |
|   |   |          |   | g |             |                                   |
|   |   |          |   | , |             |                                   |
|   |   |          |   | o |             |                                   |
|   |   |          |   | r |             |                                   |
|   |   |          |   | p |             |                                   |
|   |   |          |   | r |             |                                   |
|   |   |          |   | o |             |                                   |
|   |   |          |   | d |             |                                   |
|   |   |          |   | u |             |                                   |
|   |   |          |   | c |             |                                   |
|   |   |          |   | e |             |                                   |
|   |   |          |   | d |             |                                   |
|   |   |          |   | r |             |                                   |
|   |   |          |   | e |             |                                   |
|   |   |          |   | s |             |                                   |
|   |   |          |   | e |             |                                   |
|   |   |          |   | a |             |                                   |
|   |   |          |   | r |             |                                   |
|   |   |          |   | c |             |                                   |
|   |   |          |   | h |             |                                   |
|   |   |          |   | t |             |                                   |
|   |   |          |   | o |             |                                   |
|   |   |          |   | o |             |                                   |
|   |   |          |   | l |             |                                   |
|   |   |          |   | s |             |                                   |
|   |   |          |   | r |             |                                   |
|   |   |          |   | e |             |                                   |
|   |   |          |   | l |             |                                   |
|   |   |          |   | a |             |                                   |
|   |   |          |   | t |             |                                   |
|   |   |          |   | e |             |                                   |
|   |   |          |   | d |             |                                   |
|   |   |          |   | t |             |                                   |
|   |   |          |   | o |             |                                   |
|   |   |          |   | t |             |                                   |
|   |   |          |   | h |             |                                   |
|   |   |          |   | e |             |                                   |
|   |   |          |   | s |             |                                   |
|   |   |          |   | e |             |                                   |
|   |   |          |   | b |             |                                   |
|   |   |          |   | i |             |                                   |
|   |   |          |   | o |             |                                   |
|   |   |          |   | t |             |                                   |
|   |   |          |   | e |             |                                   |
|   |   |          |   | c |             |                                   |
|   |   |          |   | h |             |                                   |
|   |   |          |   | n |             |                                   |
|   |   |          |   | o |             |                                   |
|   |   |          |   | l |             |                                   |
|   |   |          |   | o |             |                                   |
|   |   |          |   | g |             |                                   |
|   |   |          |   | y |             |                                   |
|   |   |          |   | a |             |                                   |
|   |   |          |   | r |             |                                   |
|   |   |          |   | e |             |                                   |
|   |   |          |   | a |             |                                   |
|   |   |          |   | s |             |                                   |
|   |   |          |   | . |             |                                   |
+---+---+----------+---+---+-------------+-----------------------------------+

1)  **U.S. BIOTECHNOLOGY AND/OR BIOTECHNOLOGY COMPONENT FIRM NAME AND
    ADDRESS**: Please provide your company name and address; year of
    firm establishment; your firm's DUNS number^(1)^; and the NAICS
    code^(2)^ for your firm's primary product.

> \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
>
> Firm Name
>
> \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
>
> Street Address
>
> \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
>
> City, State, Zip Code
>
> \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
> \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
> \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
>
> Year Established DUNS Number^(1)^ Primary NAICS^(2)^
>
> \(1\) To request a DUNS Number or to find the DUNS Number already
> assigned to your firm go to <http://www.dnb.com/>

\(2\) North American Industry Classification System (NAICS) Codes:
<http://www.census.gov/epcd/www/naics.html>

\[These links will take you to a Web site outside the BIS domain. Their
privacy policies may differ from [that of
BIS](http://www.bis.doc.gov/PrivacyInfo.html).

In addition, BIS does not necessarily endorse any product, service, or
information on Web sites outside of our domain\]

2)  **OWNERSHIP**: If your firm is wholly or partly owned by another
    firm, indicate the name and address of the parent firm, extent of
    ownership, and year acquired.

> \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
>
> Firm Name
>
> \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
>
> Street Address
>
> \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
>
> City, State, Zip Code (Country)
>
> \_\_\_\_\_\_\_\_\_\_% \_\_\_\_\_\_\_\_\_\_\_\_

Ownership Year Acquired

+----------------------------------------------------------+-----------+
| 3)  Are the responses provided to this survey for more   | Yes No    |
|     than one subsidiary or establishment of your firm    |           |
|     engaged in biotechnology activities?                 |           |
+----------------------------------------------------------+-----------+
| 4)  If yes, please identify the subsidiary(ies) or other |           |
|     establishments by listing their name and address as  |           |
|     well as their DUNS number. (If more than two         |           |
|     locations, please list them on the last page of this |           |
|     survey under "Comments.")                            |           |
+----------------------------------------------------------+-----------+
|                                                          |           |
+----------------------------------------------------------+-----------+
| Name City, State DUNS Number                             |           |
+----------------------------------------------------------+-----------+
| Name City, State DUNS Number                             |           |
+----------------------------------------------------------+-----------+

5)  Indicate your firm's biotechnology activities. (Check all that
    apply.)

+------------------------+------+------+---+------+---------+---+--------+
|                        | **Re | *    |   |      | **C     | * |        |
|                        | sear | *Dev |   |      | linical | * |        |
|                        | ch** | elop |   |      | test or | A |        |
|                        |      | ment |   |      | Unc     | p |        |
|                        |      | or** |   |      | onfined | p |        |
|                        |      |      |   |      | release | r |        |
|                        |      | **   |   |      | asses   | o |        |
|                        |      | Pre- |   |      | sment** | v |        |
|                        |      | clin |   |      |         | e |        |
|                        |      | ical |   |      |         | d |        |
|                        |      | tr   |   |      |         | , |        |
|                        |      | ials |   |      |         | M |        |
|                        |      | or   |   |      |         | a |        |
|                        |      | Conf |   |      |         | r |        |
|                        |      | ined |   |      |         | k |        |
|                        |      | f    |   |      |         | e |        |
|                        |      | ield |   |      |         | t |        |
|                        |      | tes  |   |      |         | e |        |
|                        |      | ts** |   |      |         | d |        |
|                        |      |      |   |      |         | , |        |
|                        |      | #    |   |      |         | o |        |
|                        |      | #### |   |      |         | r |        |
|                        |      | #### |   |      |         | I |        |
|                        |      |   Pr |   |      |         | n |        |
|                        |      | oduc |   |      |         | p |        |
|                        |      | t \| |   |      |         | r |        |
|                        |      |  Pro |   |      |         | o |        |
|                        |      | cess |   |      |         | d |        |
|                        |      |      |   |      |         | u |        |
|                        |      |      |   |      |         | c |        |
|                        |      |      |   |      |         | t |        |
|                        |      |      |   |      |         | i |        |
|                        |      |      |   |      |         | o |        |
|                        |      |      |   |      |         | n |        |
|                        |      |      |   |      |         | * |        |
|                        |      |      |   |      |         | * |        |
|                        |      |      |   |      |         |   |        |
|                        |      |      |   |      |         | * |        |
|                        |      |      |   |      |         | * |        |
|                        |      |      |   |      |         | P |        |
|                        |      |      |   |      |         | r |        |
|                        |      |      |   |      |         | o |        |
|                        |      |      |   |      |         | d |        |
|                        |      |      |   |      |         | u |        |
|                        |      |      |   |      |         | c |        |
|                        |      |      |   |      |         | t |        |
|                        |      |      |   |      |         | s |        |
|                        |      |      |   |      |         | \ |        |
|                        |      |      |   |      |         | | |        |
|                        |      |      |   |      |         | P |        |
|                        |      |      |   |      |         | r |        |
|                        |      |      |   |      |         | o |        |
|                        |      |      |   |      |         | c |        |
|                        |      |      |   |      |         | e |        |
|                        |      |      |   |      |         | s |        |
|                        |      |      |   |      |         | s |        |
|                        |      |      |   |      |         | * |        |
|                        |      |      |   |      |         | * |        |
+------------------------+------+------+---+------+---------+---+--------+
| **DNA-Based**          |      |      |   |      |         |   |        |
+------------------------+------+------+---+------+---------+---+--------+
| Gene Probes/DNA        |      |      |   |      |         |   |        |
| Markers                |      |      |   |      |         |   |        |
+------------------------+------+------+---+------+---------+---+--------+
| Bio-Informatics        |      |      |   |      |         |   |        |
+------------------------+------+------+---+------+---------+---+--------+
| Gen                    |      |      |   |      |         |   |        |
| omics/Pharmacogenetics |      |      |   |      |         |   |        |
+------------------------+------+------+---+------+---------+---+--------+
| Genetic                |      |      |   |      |         |   |        |
| Engineering/DNA        |      |      |   |      |         |   |        |
| Sequencing/ Synthesis  |      |      |   |      |         |   |        |
| Amplification          |      |      |   |      |         |   |        |
+------------------------+------+------+---+------+---------+---+--------+
| ##### Biochem          |      |      |   |      |         |   |        |
| istry/ Immunochemistry |      |      |   |      |         |   |        |
+------------------------+------+------+---+------+---------+---+--------+
| Vaccines/Immune        |      |      |   |      |         |   |        |
| Stimulants             |      |      |   |      |         |   |        |
+------------------------+------+------+---+------+---------+---+--------+
| Drug Design & Delivery |      |      |   |      |         |   |        |
+------------------------+------+------+---+------+---------+---+--------+
| Diagnostic             |      |      |   |      |         |   |        |
| Tests/Antibiotics      |      |      |   |      |         |   |        |
+------------------------+------+------+---+------+---------+---+--------+
| Peptide/ Protein       |      |      |   |      |         |   |        |
| Sequencing/ Synthesis  |      |      |   |      |         |   |        |
+------------------------+------+------+---+------+---------+---+--------+
| Cell                   |      |      |   |      |         |   |        |
| Receptors/Signaling    |      |      |   |      |         |   |        |
| Pheromones/ Structural |      |      |   |      |         |   |        |
| Biology                |      |      |   |      |         |   |        |
+------------------------+------+------+---+------+---------+---+--------+
| Combinatorial          |      |      |   |      |         |   |        |
| Chemistry/3D Molecular |      |      |   |      |         |   |        |
| Modeling               |      |      |   |      |         |   |        |
+------------------------+------+------+---+------+---------+---+--------+
| Biomaterials           |      |      |   |      |         |   |        |
+------------------------+------+------+---+------+---------+---+--------+
| Microbiology/Virology/ |      |      |   |      |         |   |        |
| Microbial Ecology      |      |      |   |      |         |   |        |
+------------------------+------+------+---+------+---------+---+--------+
| ###                    |      |      |   |      |         |   |        |
| ## Bioprocessing Based |      |      |   |      |         |   |        |
+------------------------+------+------+---+------+---------+---+--------+
| Cell/ Tissue/Embryo    |      |      |   |      |         |   |        |
| Culture/ Manipulation  |      |      |   |      |         |   |        |
+------------------------+------+------+---+------+---------+---+--------+
| Extraction/P           |      |      |   |      |         |   |        |
| urification/Separation |      |      |   |      |         |   |        |
+------------------------+------+------+---+------+---------+---+--------+
| Ferme                  |      |      |   |      |         |   |        |
| ntation/Bioprocessing/ |      |      |   |      |         |   |        |
| Bio                    |      |      |   |      |         |   |        |
| transformation/Natural |      |      |   |      |         |   |        |
| Products Chemistry     |      |      |   |      |         |   |        |
+------------------------+------+------+---+------+---------+---+--------+
| ##### Environment      |      |      |   |      |         |   |        |
+------------------------+------+------+---+------+---------+---+--------+
| Bioleaching/Bi         |      |      |   |      |         |   |        |
| opulping/Biobleaching/ |      |      |   |      |         |   |        |
| Biodesulphurization    |      |      |   |      |         |   |        |
+------------------------+------+------+---+------+---------+---+--------+
| Biorem                 |      |      |   |      |         |   |        |
| ediation/Biofiltration |      |      |   |      |         |   |        |
+------------------------+------+------+---+------+---------+---+--------+
| **Other** (Specify):   |      |      |   |      |         |   |        |
+------------------------+------+------+---+------+---------+---+--------+
|                        |      |      |   |      |         |   |        |
+------------------------+------+------+---+------+---------+---+--------+

+-----------------------------------------------------------------------+
| 6)  A. Please briefly describe your firm's in-house biotechnology     |
|     capabilities and operations (research, production, tools).        |
+-----------------------------------------------------------------------+
|                                                                       |
+-----------------------------------------------------------------------+
|                                                                       |
+-----------------------------------------------------------------------+
|                                                                       |
+-----------------------------------------------------------------------+
|                                                                       |
+-----------------------------------------------------------------------+
|                                                                       |
+-----------------------------------------------------------------------+
| B. Please briefly describe capabilities and operations (research,     |
| production, tools) that your firm contracts out.                      |
+-----------------------------------------------------------------------+
|                                                                       |
+-----------------------------------------------------------------------+
|                                                                       |
+-----------------------------------------------------------------------+
|                                                                       |
+-----------------------------------------------------------------------+

+----------------------------------------------------------+-----------+
| 7)  Is biotechnology central to your **(firm or          | Yes No    |
|     division)**?                                         |           |
+----------------------------------------------------------+-----------+

+----------------------------------------------------------+-----------+
| 8)  Are your current physical facilities adequate to     | Yes No    |
|     serve your expected infrastructure needs for the     |           |
|     next two years?                                      |           |
+----------------------------------------------------------+-----------+

+----------------------------------------------------------+-----------+
| 9)  Is your firm contemplating (check all that apply)    |           |
+----------------------------------------------------------+-----------+
| expanding facilities/infrastructure (including lease)?   |           |
+----------------------------------------------------------+-----------+
| contracting work out to other U.S. firms/facilities?     |           |
+----------------------------------------------------------+-----------+
| contracting work out to non-U.S. firms/facilities?       |           |
+----------------------------------------------------------+-----------+
| Please explain your                                      |           |
| answer.\_\_\_\_\_\_\_\_\_                                |           |
| \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_ |           |
+----------------------------------------------------------+-----------+
| \_\_\_                                                   |           |
| \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_ |           |
| \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_ |           |
+----------------------------------------------------------+-----------+

+-----------------+-----------------+-----------------+-----------------+
| 10) If your     |                 |                 |                 |
|     firm has a  |                 |                 |                 |
|     Bio Safety  |                 |                 |                 |
|     Level       |                 |                 |                 |
|     certified   |                 |                 |                 |
|     facility,   |                 |                 |                 |
|     what is the |                 |                 |                 |
|     level of    |                 |                 |                 |
|                 |                 |                 |                 |
|  certification? |                 |                 |                 |
+-----------------+-----------------+-----------------+-----------------+
| Level 1         | Level 2         | Level 3         | Level 4         |
+-----------------+-----------------+-----------------+-----------------+

+----------------------------------------------------------+-----------+
| 11) Does your firm plan to construct a Level 3 or 4 Bio  | Yes No    |
|     Safety Level certified facility within the next      |           |
|     three years?                                         |           |
+----------------------------------------------------------+-----------+

+------------------------------------------------------------+---------+
| 12) How many full-time equivalent, in-house people does    |         |
|     your **firm or division** currently employ **in the    |         |
|     U.S.**? (Include temporary vacancies.)                 |         |
+------------------------------------------------------------+---------+

+------------------------------------------------------------+---------+
| 13) How many full-time equivalent U.S. employees have      |         |
|     biotechnology-related responsibilities?                |         |
+------------------------------------------------------------+---------+

<table>
<colgroup>
<col style="width: 40%" />
<col style="width: 8%" />
<col style="width: 5%" />
<col style="width: 6%" />
<col style="width: 8%" />
<col style="width: 5%" />
<col style="width: 5%" />
<col style="width: 8%" />
<col style="width: 5%" />
<col style="width: 5%" />
</colgroup>
<tbody>
<tr class="odd">
<td colspan="10"><ol start="14" type="1">
<li><p>For both in-house and contract <strong>employees that have
biotechnology related responsibilities</strong>, state the number of
full-time employees or full-time equivalents (<u>35-40 hours/week for a
full twelve months or working full-time on biotechnology equal to or
more than 50% of time</u>) by occupation.</p></li>
</ol></td>
</tr>
<tr class="even">
<td></td>
<td colspan="3"><strong>2000</strong></td>
<td colspan="3"><strong>2001</strong></td>
<td colspan="3"><strong>2002 (est)</strong></td>
</tr>
<tr class="odd">
<td rowspan="2"><p id="occupation" class="heading">Occupation</p></td>
<td rowspan="2"><strong>In- House</strong></td>
<td colspan="2"><strong>Contract Out</strong></td>
<td rowspan="2"><strong>In- House</strong></td>
<td colspan="2"><strong>Contract Out</strong></td>
<td rowspan="2"><strong>In- House</strong></td>
<td colspan="2"><strong>Contract Out</strong></td>
</tr>
<tr class="even">
<td><strong>D</strong></td>
<td><strong>F</strong></td>
<td><strong>D</strong></td>
<td><strong>F</strong></td>
<td><strong>D</strong></td>
<td><strong>F</strong></td>
</tr>
<tr class="odd">
<td colspan="10"><p id="biotechnology-rd-activities"
class="heading">Biotechnology R&amp;D Activities</p></td>
</tr>
<tr class="even">
<td>Scientists</td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr class="odd">
<td>Engineers</td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr class="even">
<td>Science and Clinical Laboratory Technicians</td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr class="odd">
<td>R &amp; D focused Computer Specialists</td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr class="even">
<td colspan="10"><h5
id="biotechnology-administration-production">Biotechnology
Administration &amp; Production</h5></td>
</tr>
<tr class="odd">
<td>General Operations, Marketing &amp; Financial Managers</td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr class="even">
<td>Legal (e.g., intellectual property &amp; regulatory issues)</td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr class="odd">
<td>Production Managers and Supervisors</td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr class="even">
<td>Production or Agri/Aquacultural workers</td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr class="odd">
<td colspan="10"><p><strong>D</strong> = Contract out to <strong>U.S.
located</strong> firms</p>
<p><strong>F</strong> = Contract out to <strong>Foreign located</strong>
firms</p></td>
</tr>
</tbody>
</table>

+----------------------------+---------+------------------------------+
| 15) Does your firm         |         |                              |
|     currently have any     |         |                              |
|     full-time              |         |                              |
|     biotechnology-related  |         |                              |
|     positions that have    |         |                              |
|     been unfilled for more |         |                              |
|     than three months?     |         |                              |
|                            |         |                              |
|     If                     |         |                              |
|     **[Yes]{.underline}**, |         |                              |
|     please indicate the    |         |                              |
|     number of unfilled     |         |                              |
|     positions in the       |         |                              |
|     following categories   |         |                              |
|     and identify the       |         |                              |
|     reason that the        |         |                              |
|     position is presently  |         |                              |
|     unfilled.              |         |                              |
|                            |         |                              |
|     If                     |         |                              |
|                            |         |                              |
|    **[None]{.underline}**, |         |                              |
|     check No and proceed   |         |                              |
|     to the next question.  |         |                              |
|     No                     |         |                              |
+----------------------------+---------+------------------------------+
| ########                   | > *     | **Reason:**                  |
|                            | *Number |                              |
| ########                   | > of    |                              |
|                            | > Po    |                              |
| ########                   | sitions |                              |
|                            | > U     |                              |
| ########                   | nfilled |                              |
| Occupation {#occupation-1} | > for   |                              |
|                            | > more  |                              |
|                            | > than  |                              |
|                            | > 3     |                              |
|                            | > m     |                              |
|                            | onths** |                              |
+----------------------------+---------+------------------------------+
| ###                        |         |                              |
| ## Biotechnology Research  |         |                              |
| and Development Activities |         |                              |
+----------------------------+---------+------------------------------+
| Scientists                 |         |                              |
+----------------------------+---------+------------------------------+
| Engineers                  |         |                              |
+----------------------------+---------+------------------------------+
| Science and Clinical       |         |                              |
| Laboratory Technicians     |         |                              |
+----------------------------+---------+------------------------------+
| R & D focused Computer     |         |                              |
| Specialists                |         |                              |
+----------------------------+---------+------------------------------+
| ##### Biotechn             |         |                              |
| ology Administration & Pro |         |                              |
| duction {#biotechnology-ad |         |                              |
| ministration-production-1} |         |                              |
+----------------------------+---------+------------------------------+
| General, Operations,       |         |                              |
| Marketing, and Financial   |         |                              |
| Managers                   |         |                              |
+----------------------------+---------+------------------------------+
| Legal (e.g., intellectual  |         |                              |
| property and regulatory    |         |                              |
| issues)                    |         |                              |
+----------------------------+---------+------------------------------+
| Production Managers or     |         |                              |
| Supervisors                |         |                              |
+----------------------------+---------+------------------------------+
| Production or              |         |                              |
| Agri/Aquacultural workers  |         |                              |
+----------------------------+---------+------------------------------+

+--------------------------------------------------------------+-------+
| 16) What is your average annual employee turnover rate for   | **%** |
|     employees with primarily biotechnology-related           |       |
|     responsibilities?                                        |       |
+--------------------------------------------------------------+-------+

+--------------------------------------------------------------+-------+
| 17) Please identify the percentage (%) of your firm's        |       |
|     biotechnology work force that is obtained from the       |       |
|     following sources (because categories may overlap,       |       |
|     percentages need not add up to 100%).                    |       |
+--------------------------------------------------------------+-------+
| Recruited from the local labor market/U.S. firms             | \%    |
+--------------------------------------------------------------+-------+
| Recruited from U.S. 4-year degree or post-graduate degree    | \%    |
| granting colleges/universities                               |       |
+--------------------------------------------------------------+-------+
| Recruited from U.S. 2-year community or junior colleges, or  | \%    |
| technical schools                                            |       |
+--------------------------------------------------------------+-------+
| Foreign employees with a U.S. visa or work permit            | \%    |
+--------------------------------------------------------------+-------+
| Foreign employees residing abroad                            | \%    |
+--------------------------------------------------------------+-------+

+--------------------------------------------------------------+-------+
| 18) Please estimate the percentage (%) of your workforce     |       |
|     needs that are fulfilled by the following:               |       |
+--------------------------------------------------------------+-------+
| Contracting out to other U.S. headquartered firms            | \%    |
+--------------------------------------------------------------+-------+
| Contracting out to foreign firms operating abroad            | \%    |
+--------------------------------------------------------------+-------+
| Contracting out to a U.S. university, college, or nonprofit  | \%    |
| organization                                                 |       |
+--------------------------------------------------------------+-------+

+--------------------------------------------------------------+-------+
| 19) Please indicate all occupations that will be the focus   |       |
|     of your company's recruiting efforts in the next         |       |
|     **three** years (replacement hires and new positions):   |       |
+--------------------------------------------------------------+-------+
| ##### Biotechnology Research and Development Activities      |       |
+--------------------------------------------------------------+-------+
| Scientists                                                   |       |
+--------------------------------------------------------------+-------+
| Engineers                                                    |       |
+--------------------------------------------------------------+-------+
| Science and Clinical Laboratory Technicians                  |       |
+--------------------------------------------------------------+-------+
| R & D focused Computer Specialists                           |       |
+--------------------------------------------------------------+-------+
| ##### Biotechnology Administration and Production            |       |
+--------------------------------------------------------------+-------+
| General Operations, Marketing and Financial Managers         |       |
+--------------------------------------------------------------+-------+
| Legal (e.g., intellectual property and regulatory issues)    |       |
+--------------------------------------------------------------+-------+
| Production Managers and Supervisors                          |       |
+--------------------------------------------------------------+-------+
| Production or Agri/Aquacultural workers                      |       |
+--------------------------------------------------------------+-------+

+---+---+------------------------+---+---------------------------------+
| 2 |   |                        |   |                                 |
| 0 |   |                        |   |                                 |
| ) |   |                        |   |                                 |
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| f |   |                        |   |                                 |
| o |   |                        |   |                                 |
| r |   |                        |   |                                 |
|   |   |                        |   |                                 |
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|   |   |                        |   |                                 |
|   |   |                        |   |                                 |
| y |   |                        |   |                                 |
| o |   |                        |   |                                 |
| u |   |                        |   |                                 |
| r |   |                        |   |                                 |
|   |   |                        |   |                                 |
|   |   |                        |   |                                 |
|   |   |                        |   |                                 |
|   |   |                        |   |                                 |
| f |   |                        |   |                                 |
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| r |   |                        |   |                                 |
| m |   |                        |   |                                 |
| ? |   |                        |   |                                 |
+---+---+------------------------+---+---------------------------------+
|   |   | In-house training      |   | Establish foreign facilities to |
|   |   |                        |   | gain access to more workers     |
+---+---+------------------------+---+---------------------------------+
|   |   | College recruiting     |   | Recruiting bonuses              |
+---+---+------------------------+---+---------------------------------+
|   |   | Increase salaries      |   | Enhanced benefit plans          |
+---+---+------------------------+---+---------------------------------+
|   |   | Overtime incentives    |   | Subcontract to another company  |
|   |   |                        |   | or academia                     |
+---+---+------------------------+---+---------------------------------+
|   |   | Foreign recruiting     |   | Outsourcing                     |
+---+---+------------------------+---+---------------------------------+
|   |   | Other                  |   |                                 |
|   |   | (Specify)\_\_          |   |                                 |
|   |   | \_\_\_\_\_\_\_\_\_\_\_ |   |                                 |
|   |   | \_\_\_\_\_\_\_\_\_\_\_ |   |                                 |
|   |   | \_\_\_\_\_\_\_\_\_\_\_ |   |                                 |
|   |   | \_\_\_\_\_\_\_\_\_\_\_ |   |                                 |
|   |   | \_\_\_\_\_\_\_\_\_\_\_ |   |                                 |
+---+---+------------------------+---+---------------------------------+

+-----------------+----------------+----------------+-----------------+
| 21) If your     |                |                |                 |
|     firm's U.S. |                |                |                 |
|     operations  |                |                |                 |
|     recruit     |                |                |                 |
|     workers     |                |                |                 |
|     from        |                |                |                 |
|     abroad,     |                |                |                 |
|     list the    |                |                |                 |
|     top four    |                |                |                 |
|     countries   |                |                |                 |
|     that        |                |                |                 |
|     provide a   |                |                |                 |
|     source of   |                |                |                 |
|     employees.  |                |                |                 |
+-----------------+----------------+----------------+-----------------+
| 1-              | 2-             | 3-             | 4-              |
+-----------------+----------------+----------------+-----------------+

+----------------------------------------------------------+-----------+
| 22) What percentage of your work force requires security | \%        |
|     clearances to perform work for U.S. Government       |           |
|     Departments or Agencies?                             |           |
+----------------------------------------------------------+-----------+

+------------------------------------+------+------+-------+--------+
| 23) Please provide **[Financial    |      |      |       |        |
|     Data]{.underline}** as         |      |      |       |        |
|     specified for the fiscal years |      |      |       |        |
|     below:^\*^                     |      |      |       |        |
|                                    |      |      |       |        |
|     (in \$000s: e.g., \$25,000 =   |      |      |       |        |
|     \$25).                         |      |      |       |        |
+------------------------------------+------+------+-------+--------+
| **Category**                       | **20 | **20 | *     | **2003 |
|                                    | 00** | 01** | *2002 | (      |
|                                    |      |      | (e    | est)** |
|                                    | **(\ | **(\ | st)** |        |
|                                    | $000 | $000 |       | **(\$0 |
|                                    | s)** | s)** | **    | 00s)** |
|                                    |      |      | (\$00 |        |
|                                    |      |      | 0s)** |        |
+------------------------------------+------+------+-------+--------+
| **For Entire Business (i.e.,       |      |      |       |        |
| biotechnology and                  |      |      |       |        |
| non-biotechnology)**               |      |      |       |        |
+------------------------------------+------+------+-------+--------+
| Net Sales                          |      |      |       |        |
+------------------------------------+------+------+-------+--------+
| Cost of Goods Sold                 |      |      |       |        |
+------------------------------------+------+------+-------+--------+
| Selling, General, and              |      |      |       |        |
| Administrative Expenses            |      |      |       |        |
+------------------------------------+------+------+-------+--------+
| Operating Income (line 1 minus     |      |      |       |        |
| lines (2+3)                        |      |      |       |        |
+------------------------------------+------+------+-------+--------+
| # For Biotechnology Only           |      |      |       |        |
+------------------------------------+------+------+-------+--------+
| Net Sales                          |      |      |       |        |
+------------------------------------+------+------+-------+--------+
| Cost of Goods Sold                 |      |      |       |        |
+------------------------------------+------+------+-------+--------+
| Selling, General, and              |      |      |       |        |
| Administrative Expenses            |      |      |       |        |
+------------------------------------+------+------+-------+--------+
| Operating Income (line 1 minus     |      |      |       |        |
| lines (2+3)                        |      |      |       |        |
+------------------------------------+------+------+-------+--------+

\* **Companies with 50 employees or less are only required to provide
2001 data**

+------------------------------------+------+------+-------+--------+
| 24) Please provide **[Research and |      |      |       |        |
|     Development                    |      |      |       |        |
|     Expenditures]{.underline}** as |      |      |       |        |
|     specified for the years        |      |      |       |        |
|     below:^\*^ (in \$000s: e.g.,   |      |      |       |        |
|     \$25,000 = \$25)               |      |      |       |        |
+------------------------------------+------+------+-------+--------+
| **Category**                       | **20 | **20 | *     | **2003 |
|                                    | 00** | 01** | *2002 | (      |
|                                    |      |      | (e    | est)** |
|                                    | **(\ | **(\ | st)** |        |
|                                    | $000 | $000 |       | **(\$0 |
|                                    | s)** | s)** | **    | 00s)** |
|                                    |      |      | (\$00 |        |
|                                    |      |      | 0s)** |        |
+------------------------------------+------+------+-------+--------+
| **For Entire Business (i.e.,       |      |      |       |        |
| biotechnology and                  |      |      |       |        |
| non-biotechnology)**               |      |      |       |        |
+------------------------------------+------+------+-------+--------+
| Research                           |      |      |       |        |
+------------------------------------+------+------+-------+--------+
| Development                        |      |      |       |        |
+------------------------------------+------+------+-------+--------+
| Total R&D                          |      |      |       |        |
+------------------------------------+------+------+-------+--------+
| # For Biotechnology Only           |      |      |       |        |
+------------------------------------+------+------+-------+--------+
| Research                           |      |      |       |        |
+------------------------------------+------+------+-------+--------+
| Development                        |      |      |       |        |
+------------------------------------+------+------+-------+--------+
| Total R&D                          |      |      |       |        |
+------------------------------------+------+------+-------+--------+

\* **Companies with 50 employees or less are only required to provide
2001 data**

+-------------+---+-------+-----+--------+----------+--------------------+
| 25) If your |   |       |     |        |          |                    |
|     firm    |   |       |     |        |          |                    |
|     works   |   |       |     |        |          |                    |
|     with    |   |       |     |        |          |                    |
|     any     |   |       |     |        |          |                    |
|     federal |   |       |     |        |          |                    |
|     agency  |   |       |     |        |          |                    |
|     in any  |   |       |     |        |          |                    |
|     of the  |   |       |     |        |          |                    |
|             |   |       |     |        |          |                    |
|   following |   |       |     |        |          |                    |
|     ways as |   |       |     |        |          |                    |
|     part of |   |       |     |        |          |                    |
|     your    |   |       |     |        |          |                    |
|     bi      |   |       |     |        |          |                    |
| otechnology |   |       |     |        |          |                    |
|             |   |       |     |        |          |                    |
| activities, |   |       |     |        |          |                    |
|     please  |   |       |     |        |          |                    |
|             |   |       |     |        |          |                    |
|    indicate |   |       |     |        |          |                    |
|     the     |   |       |     |        |          |                    |
|     agency. |   |       |     |        |          |                    |
|     See the |   |       |     |        |          |                    |
|     boxes   |   |       |     |        |          |                    |
|     at the  |   |       |     |        |          |                    |
|     bottom  |   |       |     |        |          |                    |
|     of the  |   |       |     |        |          |                    |
|     table   |   |       |     |        |          |                    |
|     for     |   |       |     |        |          |                    |
|             |   |       |     |        |          |                    |
| definitions |   |       |     |        |          |                    |
|     of      |   |       |     |        |          |                    |
|     abb     |   |       |     |        |          |                    |
| reviations. |   |       |     |        |          |                    |
+-------------+---+-------+-----+--------+----------+--------------------+
| ##          |   | ###   |     |        |          |                    |
| # Programs  |   | Agenc |     |        |          |                    |
|             |   | y (s) |     |        |          |                    |
+-------------+---+-------+-----+--------+----------+--------------------+
| Grants      |   |       |     | NASA   | SBA      |                    |
| Programs    | A |       | DoS |        |          |                    |
|             | R |       |     | NIH    | USDA     |                    |
| SBIR        | S |       | DoT |        |          |                    |
|             |   |       |     | NIST   | VA       |                    |
| STTR        | C |       | EPA |        |          |                    |
|             | D |       |     | NOAA   | Other    |                    |
| Other       | C |       | FDA |        | \_\_\_   |                    |
| Grants      |   |       |     | NSF    | \_\_\_\_ |                    |
|             | D |       | HHS |        | \_\_\_\_ |                    |
|             | o |       |     |        | \_\_\_\_ |                    |
|             | D |       |     |        | \_\_\_\_ |                    |
|             |   |       |     |        | \_\_\_\_ |                    |
|             | D |       |     |        | \_\_\_\_ |                    |
|             | o |       |     |        | \_\_\_\_ |                    |
|             | E |       |     |        | \_\_\_\_ |                    |
|             |   |       |     |        |          |                    |
|             | D |       |     |        |          |                    |
|             | o |       |     |        |          |                    |
|             | J |       |     |        |          |                    |
+-------------+---+-------+-----+--------+----------+--------------------+
| Technical   |   |       |     | NASA   | SBA      |                    |
| Assistance  | A |       | DoS |        |          |                    |
| Programs    | R |       |     | NIH    | USDA     |                    |
|             | S |       | DoT |        |          |                    |
| (BMP,       |   |       |     | NIST   | VA       |                    |
| MEP...)     | C |       | EPA |        |          |                    |
|             | D |       |     | NOAA   | Other    |                    |
|             | C |       | FDA |        | \_\_     |                    |
|             |   |       |     | NSF    | \_\_\_\_ |                    |
|             | D |       | HHS |        | \_\_\_\_ |                    |
|             | o |       |     |        | \_\_\_\_ |                    |
|             | D |       |     |        | \_\_\_\_ |                    |
|             |   |       |     |        | \_\_\_\_ |                    |
|             | D |       |     |        | \_\_\_\_ |                    |
|             | o |       |     |        | \_\_\_\_ |                    |
|             | E |       |     |        | \_\_\_\_ |                    |
|             |   |       |     |        |          |                    |
|             | D |       |     |        |          |                    |
|             | o |       |     |        |          |                    |
|             | J |       |     |        |          |                    |
+-------------+---+-------+-----+--------+----------+--------------------+
| Government  |   |       |     | NASA   | SBA      |                    |
| Loan        | A |       | DoS |        |          |                    |
| Programs    | R |       |     | NIH    | USDA     |                    |
|             | S |       | DoT |        |          |                    |
|             |   |       |     | NIST   | VA       |                    |
|             | C |       | EPA |        |          |                    |
|             | D |       |     | NOAA   | Other    |                    |
|             | C |       | FDA |        | \_\_     |                    |
|             |   |       |     | NSF    | \_\_\_\_ |                    |
|             | D |       | HHS |        | \_\_\_\_ |                    |
|             | o |       |     |        | \_\_\_\_ |                    |
|             | D |       |     |        | \_\_\_\_ |                    |
|             |   |       |     |        | \_\_\_\_ |                    |
|             | D |       |     |        | \_\_\_\_ |                    |
|             | o |       |     |        | \_\_\_\_ |                    |
|             | E |       |     |        | \_\_\_\_ |                    |
|             |   |       |     |        |          |                    |
|             | D |       |     |        |          |                    |
|             | o |       |     |        |          |                    |
|             | J |       |     |        |          |                    |
+-------------+---+-------+-----+--------+----------+--------------------+
| Contracts   |   |       |     | NASA   | SBA      |                    |
| (including  | A |       | DoS |        |          |                    |
| ACTD, ATD,  | R |       |     | NIH    | USDA     |                    |
| SBIR &      | S |       | DoT |        |          |                    |
| STTR)       |   |       |     | NIST   | VA       |                    |
|             | C |       | EPA |        |          |                    |
| CRADA       | D |       |     | NOAA   | Other    |                    |
|             | C |       | FDA |        | \_\_     |                    |
| I           |   |       |     | NSF    | \_\_\_\_ |                    |
| n-Licensing | D |       | HHS |        | \_\_\_\_ |                    |
|             | o |       |     |        | \_\_\_\_ |                    |
|             | D |       |     |        | \_\_\_\_ |                    |
|             |   |       |     |        | \_\_\_\_ |                    |
|             | D |       |     |        | \_\_\_\_ |                    |
|             | o |       |     |        | \_\_\_\_ |                    |
|             | E |       |     |        | \_\_\_\_ |                    |
|             |   |       |     |        |          |                    |
|             | D |       |     |        |          |                    |
|             | o |       |     |        |          |                    |
|             | J |       |     |        |          |                    |
+-------------+---+-------+-----+--------+----------+--------------------+
|             |   |       |     | NASA   | SBA      |                    |
| \"Work-f    | A |       | DoS |        |          |                    |
| or-others\" | R |       |     | NIH    | USDA     |                    |
| done at     | S |       | DoT |        |          |                    |
| federal     |   |       |     | NIST   | VA       |                    |
| l           | C |       | EPA |        |          |                    |
| aboratories | D |       |     | NOAA   | Other    |                    |
|             | C |       | FDA |        | \_\_     |                    |
| Other       |   |       |     | NSF    | \_\_\_\_ |                    |
| (specify)   | D |       | HHS |        | \_\_\_\_ |                    |
|             | o |       |     |        | \_\_\_\_ |                    |
|             | D |       |     |        | \_\_\_\_ |                    |
|             |   |       |     |        | \_\_\_\_ |                    |
|             | D |       |     |        | \_\_\_\_ |                    |
|             | o |       |     |        | \_\_\_\_ |                    |
|             | E |       |     |        | \_\_\_\_ |                    |
|             |   |       |     |        |          |                    |
|             | D |       |     |        |          |                    |
|             | o |       |     |        |          |                    |
|             | J |       |     |        |          |                    |
+-------------+---+-------+-----+--------+----------+--------------------+
| **[Pr       |   |       |     | **[    |          | HHS=Department of  |
| ograms:]{.u |   |       |     | Agenci |          | Health and Human   |
| nderline}** |   |       |     | es:]{. |          | Services;          |
|             |   |       |     | underl |          |                    |
| AC          |   |       |     | ine}** |          | NASA=National      |
| TD=Advanced |   |       |     | (not   |          | Aeronautics &      |
| Concept     |   |       |     | al     |          | Space              |
| Technology  |   |       |     | l-incl |          | Administration;    |
| Dem         |   |       |     | usive) |          |                    |
| onstration; |   |       |     |        |          | NIH=National       |
|             |   |       |     | ARS    |          | Institutes of      |
| A           |   |       |     | =Agric |          | Health;            |
| TD=Advanced |   |       |     | ulture |          |                    |
| Technology  |   |       |     | Re     |          | NIST=National      |
| Dem         |   |       |     | search |          | Institute of       |
| onstration; |   |       |     | Se     |          | Standards &        |
|             |   |       |     | rvice; |          | Technology;        |
| BMP=Best    |   |       |     |        |          |                    |
| Ma          |   |       |     | CDC=C  |          | NOAA=National      |
| nufacturing |   |       |     | enters |          | Oceanic and        |
| Practices;  |   |       |     | for    |          | Atmospheric        |
|             |   |       |     | D      |          | Administration;    |
| CRADA=      |   |       |     | isease |          |                    |
| Cooperative |   |       |     | Co     |          | NSF=National       |
| Research    |   |       |     | ntrol; |          | Science            |
| and         |   |       |     |        |          | Foundation;        |
| Development |   |       |     | Do     |          |                    |
| Agreement;  |   |       |     | D=Depa |          | SBA=Small Business |
|             |   |       |     | rtment |          | Administration;    |
| MANTECH=Ma  |   |       |     | of     |          |                    |
| nufacturing |   |       |     | De     |          | USDA= Department   |
| Technology; |   |       |     | fense; |          | of Agriculture;    |
|             |   |       |     |        |          |                    |
| MEP=Ma      |   |       |     | DoE=   |          | VA=Veterans        |
| nufacturing |   |       |     | Depa   |          | Administration     |
| Extension   |   |       |     | rtment |          |                    |
| Program;    |   |       |     | of     |          |                    |
|             |   |       |     | E      |          |                    |
| SBIR=Small  |   |       |     | nergy; |          |                    |
| Business    |   |       |     |        |          |                    |
| Innovation  |   |       |     | Do     |          |                    |
| Research;   |   |       |     | J=Depa |          |                    |
|             |   |       |     | rtment |          |                    |
| STTR=Small  |   |       |     | of     |          |                    |
| Business    |   |       |     | Ju     |          |                    |
| Technology  |   |       |     | stice, |          |                    |
| Transfer    |   |       |     | inc    |          |                    |
|             |   |       |     | luding |          |                    |
|             |   |       |     | the    |          |                    |
|             |   |       |     | FBI    |          |                    |
|             |   |       |     | (F     |          |                    |
|             |   |       |     | ederal |          |                    |
|             |   |       |     | Bureau |          |                    |
|             |   |       |     | of     |          |                    |
|             |   |       |     | Inv    |          |                    |
|             |   |       |     | estiga |          |                    |
|             |   |       |     | tion); |          |                    |
|             |   |       |     |        |          |                    |
|             |   |       |     | Do     |          |                    |
|             |   |       |     | S=Depa |          |                    |
|             |   |       |     | rtment |          |                    |
|             |   |       |     | of     |          |                    |
|             |   |       |     | State; |          |                    |
|             |   |       |     |        |          |                    |
|             |   |       |     | Do     |          |                    |
|             |   |       |     | T=Depa |          |                    |
|             |   |       |     | rtment |          |                    |
|             |   |       |     | of     |          |                    |
|             |   |       |     | Tre    |          |                    |
|             |   |       |     | asury; |          |                    |
|             |   |       |     |        |          |                    |
|             |   |       |     | EPA=E  |          |                    |
|             |   |       |     | nviron |          |                    |
|             |   |       |     | mental |          |                    |
|             |   |       |     | Prot   |          |                    |
|             |   |       |     | ection |          |                    |
|             |   |       |     | A      |          |                    |
|             |   |       |     | gency; |          |                    |
|             |   |       |     |        |          |                    |
|             |   |       |     | FD     |          |                    |
|             |   |       |     | A=Food |          |                    |
|             |   |       |     | and    |          |                    |
|             |   |       |     | Drug   |          |                    |
|             |   |       |     | Ad     |          |                    |
|             |   |       |     | minist |          |                    |
|             |   |       |     | ration |          |                    |
+-------------+---+-------+-----+--------+----------+--------------------+

+-----------------------------------+------+------+---------+---------+
| 26) Provide **[Capital            |      |      |         |         |
|     Expenditures]{.underline}**   |      |      |         |         |
|     as specified for the fiscal   |      |      |         |         |
|     years below:^\*^              |      |      |         |         |
|                                   |      |      |         |         |
|     (in \$000s: e.g., \$25,000 =  |      |      |         |         |
|     \$25).                        |      |      |         |         |
+-----------------------------------+------+------+---------+---------+
| **Category**                      | **20 | **20 | **2002  | **2003  |
|                                   | 00** | 01** | (est)** | (est)** |
|                                   |      |      |         |         |
|                                   | **(\ | **(\ | **(\$   | **(\$   |
|                                   | $000 | $000 | 000s)** | 000s)** |
|                                   | s)** | s)** |         |         |
+-----------------------------------+------+------+---------+---------+
| **For Entire Business (i.e.,      |      |      |         |         |
| biotechnology and                 |      |      |         |         |
| non-biotechnology)**              |      |      |         |         |
+-----------------------------------+------+------+---------+---------+
| New Plant and Facilities          |      |      |         |         |
+-----------------------------------+------+------+---------+---------+
| New Machinery and Equipment       |      |      |         |         |
+-----------------------------------+------+------+---------+---------+
| Total Capital Expenditures        |      |      |         |         |
+-----------------------------------+------+------+---------+---------+
| # For Biotechnology Only          |      |      |         |         |
+-----------------------------------+------+------+---------+---------+
| New Plant and Facilities          |      |      |         |         |
+-----------------------------------+------+------+---------+---------+
| New Machinery and Equipment       |      |      |         |         |
+-----------------------------------+------+------+---------+---------+
| Total Capital Expenditures        |      |      |         |         |
+-----------------------------------+------+------+---------+---------+

\* **Companies with 50 employees or less are only required to provide
2001 data**

+--------------------+-----------+-----------+------------+------------+
| 2                  |           |           |            |            |
| 7) **Biotechnology |           |           |            |            |
|     Research and   |           |           |            |            |
|                    |           |           |            |            |
|    Development** - |           |           |            |            |
|     Provide the    |           |           |            |            |
|     **[total       |           |           |            |            |
|     amo            |           |           |            |            |
| unt]{.underline}** |           |           |            |            |
|     expended (*or  |           |           |            |            |
|     that is        |           |           |            |            |
|     projected to   |           |           |            |            |
|     be spent*) by  |           |           |            |            |
|     your firm on   |           |           |            |            |
|     biotechnology  |           |           |            |            |
|     research and   |           |           |            |            |
|     development    |           |           |            |            |
|     for *business  |           |           |            |            |
|     fiscal years*  |           |           |            |            |
|     2000 through   |           |           |            |            |
|     2003 (in       |           |           |            |            |
|     \$000s:        |           |           |            |            |
|                    |           |           |            |            |
|    \$25=\$25,000). |           |           |            |            |
|     ^\*^           |           |           |            |            |
+--------------------+-----------+-----------+------------+------------+
| **Year**           | **2000    | **2001    | **2002     | **2003     |
|                    | Total**   | Total**   | Total      | Total      |
|                    |           |           | (est)**    | (est)**    |
|                    | **        | **        |            |            |
|                    | (\$000)** | (\$000)** | *          | *          |
|                    |           |           | *(\$000)** | *(\$000)** |
+--------------------+-----------+-----------+------------+------------+
| Biotechnology R&D  |           |           |            |            |
| Expenditures       |           |           |            |            |
+--------------------+-----------+-----------+------------+------------+
| Identify **[the    |           |           |            |            |
| percent            |           |           |            |            |
| age]{.underline}** |           |           |            |            |
| of your total R&D  |           |           |            |            |
| budget (as         |           |           |            |            |
| reported above)    |           |           |            |            |
| that individual    |           |           |            |            |
| sources represent  |           |           |            |            |
| in each year.^\*^  |           |           |            |            |
+--------------------+-----------+-----------+------------+------------+
| # Funding Sources  | **2000    | **2001    | **2002     | **2003     |
|                    | %**       | %**       | (est) %**  | (est) %**  |
+--------------------+-----------+-----------+------------+------------+
| In-House Revenue   |           |           |            |            |
+--------------------+-----------+-----------+------------+------------+
| Parent Firm        |           |           |            |            |
| Funding            |           |           |            |            |
+--------------------+-----------+-----------+------------+------------+
| Conventional Loans |           |           |            |            |
+--------------------+-----------+-----------+------------+------------+
| Angel Investors    |           |           |            |            |
+--------------------+-----------+-----------+------------+------------+
| Venture Capital    |           |           |            |            |
| Firms              |           |           |            |            |
+--------------------+-----------+-----------+------------+------------+
| Initial Public     |           |           |            |            |
| Offering           |           |           |            |            |
+--------------------+-----------+-----------+------------+------------+
| U.S. Gov't         |           |           |            |            |
| Loan/Grant         |           |           |            |            |
+--------------------+-----------+-----------+------------+------------+
| State Gov't        |           |           |            |            |
| Loan/Grant         |           |           |            |            |
+--------------------+-----------+-----------+------------+------------+
| Foreign Gov't      |           |           |            |            |
| Loan/Grant         |           |           |            |            |
+--------------------+-----------+-----------+------------+------------+
| Private Research   |           |           |            |            |
| Grants             |           |           |            |            |
+--------------------+-----------+-----------+------------+------------+
| Other (specify)    |           |           |            |            |
+--------------------+-----------+-----------+------------+------------+
| Other (specify)    |           |           |            |            |
+--------------------+-----------+-----------+------------+------------+
| ####### Total      | **100%**  | **100%**  | **100%**   | **100%**   |
+--------------------+-----------+-----------+------------+------------+
| **\*Companies with |           |           |            |            |
| 50 employees or    |           |           |            |            |
| less are only      |           |           |            |            |
| required to        |           |           |            |            |
| provide 2001       |           |           |            |            |
| data.**            |           |           |            |            |
+--------------------+-----------+-----------+------------+------------+

+--------------------+-----------+-----------+------------+-----------+
| 28) **Exports**:   |           |           |            |           |
|     What percent   |           |           |            |           |
|     of your net    |           |           |            |           |
|     revenues are   |           |           |            |           |
|     generated from |           |           |            |           |
|     exports of     |           |           |            |           |
|     biotechnology  |           |           |            |           |
|     products or    |           |           |            |           |
|     processes by   |           |           |            |           |
|     fiscal year    |           |           |            |           |
|                    |           |           |            |           |
|   (2000-2003)^\*^? |           |           |            |           |
+--------------------+-----------+-----------+------------+-----------+
| ##### Year         | **2000**  | **2001**  | **2002     | **2003    |
|                    |           |           | (est)**    | (est)**   |
+--------------------+-----------+-----------+------------+-----------+
| Percent of Net     | \%        | \%        | \%         | \%        |
| Revenue            |           |           |            |           |
+--------------------+-----------+-----------+------------+-----------+
| **\*Companies with |           |           |            |           |
| 50 employees or    |           |           |            |           |
| less are only      |           |           |            |           |
| required to        |           |           |            |           |
| provide 2001       |           |           |            |           |
| data.**            |           |           |            |           |
+--------------------+-----------+-----------+------------+-----------+

+-------------------+-----------+-----------+------------+------------+
| 29) For the years |           |           |            |            |
|     your firm     |           |           |            |            |
|     exported      |           |           |            |            |
|     biotechnology |           |           |            |            |
|     products or   |           |           |            |            |
|     processes,    |           |           |            |            |
|     please        |           |           |            |            |
|     provide a     |           |           |            |            |
|     percentage    |           |           |            |            |
|     breakout of   |           |           |            |            |
|     your export   |           |           |            |            |
|     revenues by   |           |           |            |            |
|     geographic    |           |           |            |            |
|     location.^\*^ |           |           |            |            |
+-------------------+-----------+-----------+------------+------------+
| ##### Location    | **2000**  | **2001**  | **2002     | **2003     |
|                   |           |           | (est)**    | (est)**    |
+-------------------+-----------+-----------+------------+------------+
| Canada            | \%        | \%        | \%         | \%         |
+-------------------+-----------+-----------+------------+------------+
|                   |           |           |            |            |
+-------------------+-----------+-----------+------------+------------+
| Mexico            | \%        | \%        | \%         | \%         |
+-------------------+-----------+-----------+------------+------------+
| Brazil            |           |           |            |            |
+-------------------+-----------+-----------+------------+------------+
| Other Latin       |           |           |            |            |
| America           |           |           |            |            |
+-------------------+-----------+-----------+------------+------------+
|                   |           |           |            |            |
+-------------------+-----------+-----------+------------+------------+
| UK                | \%        | \%        | \%         | \%         |
+-------------------+-----------+-----------+------------+------------+
| Germany           |           |           |            |            |
+-------------------+-----------+-----------+------------+------------+
| France            |           |           |            |            |
+-------------------+-----------+-----------+------------+------------+
| Russia            |           |           |            |            |
+-------------------+-----------+-----------+------------+------------+
| Other EU          |           |           |            |            |
+-------------------+-----------+-----------+------------+------------+
|                   |           |           |            |            |
+-------------------+-----------+-----------+------------+------------+
| Australia         | \%        | \%        | \%         | \%         |
+-------------------+-----------+-----------+------------+------------+
| India             |           |           |            |            |
+-------------------+-----------+-----------+------------+------------+
| Israel            |           |           |            |            |
+-------------------+-----------+-----------+------------+------------+
| Korea             |           |           |            |            |
+-------------------+-----------+-----------+------------+------------+
| Japan             |           |           |            |            |
+-------------------+-----------+-----------+------------+------------+
| China             |           |           |            |            |
+-------------------+-----------+-----------+------------+------------+
| Other Asia        |           |           |            |            |
+-------------------+-----------+-----------+------------+------------+
|                   |           |           |            |            |
+-------------------+-----------+-----------+------------+------------+
| Other (Specify)   | \%        | \%        | \%         | \%         |
+-------------------+-----------+-----------+------------+------------+
| **Total**         | **100%**  | **100%**  | **100%**   | **100%**   |
+-------------------+-----------+-----------+------------+------------+

**\* Companies with fewer than 50 employees are only required to
complete 2001 data**

# 

+----+--------------------------+----+--------------------------------+
| 3  |                          |    |                                |
| 0) |                          |    |                                |
|  W |                          |    |                                |
| hi |                          |    |                                |
| ch |                          |    |                                |
|    |                          |    |                                |
|    |                          |    |                                |
| of |                          |    |                                |
|    |                          |    |                                |
|    |                          |    |                                |
|  t |                          |    |                                |
| he |                          |    |                                |
|    |                          |    |                                |
|    |                          |    |                                |
|  f |                          |    |                                |
| ol |                          |    |                                |
| lo |                          |    |                                |
| wi |                          |    |                                |
| ng |                          |    |                                |
|    |                          |    |                                |
|    |                          |    |                                |
| st |                          |    |                                |
| ra |                          |    |                                |
| te |                          |    |                                |
| gi |                          |    |                                |
| es |                          |    |                                |
|    |                          |    |                                |
|    |                          |    |                                |
| do |                          |    |                                |
| es |                          |    |                                |
|    |                          |    |                                |
|    |                          |    |                                |
| yo |                          |    |                                |
| ur |                          |    |                                |
|    |                          |    |                                |
|    |                          |    |                                |
| fi |                          |    |                                |
| rm |                          |    |                                |
|    |                          |    |                                |
|    |                          |    |                                |
| pl |                          |    |                                |
| an |                          |    |                                |
|    |                          |    |                                |
|    |                          |    |                                |
| to |                          |    |                                |
|    |                          |    |                                |
|    |                          |    |                                |
|  u |                          |    |                                |
| se |                          |    |                                |
|    |                          |    |                                |
|    |                          |    |                                |
| in |                          |    |                                |
|    |                          |    |                                |
|    |                          |    |                                |
| 20 |                          |    |                                |
| 02 |                          |    |                                |
| -2 |                          |    |                                |
| 00 |                          |    |                                |
| 3? |                          |    |                                |
|    |                          |    |                                |
|    |                          |    |                                |
| (* |                          |    |                                |
| *C |                          |    |                                |
| he |                          |    |                                |
| ck |                          |    |                                |
|    |                          |    |                                |
|    |                          |    |                                |
|  a |                          |    |                                |
| ll |                          |    |                                |
|    |                          |    |                                |
|    |                          |    |                                |
| th |                          |    |                                |
| at |                          |    |                                |
|    |                          |    |                                |
|    |                          |    |                                |
| ap |                          |    |                                |
| pl |                          |    |                                |
| y* |                          |    |                                |
| *) |                          |    |                                |
+----+--------------------------+----+--------------------------------+
|    | Refocus product          |    | License-in technology          |
|    | development              |    |                                |
+----+--------------------------+----+--------------------------------+
|    | Refocus R&D activities   |    | License-out technology         |
+----+--------------------------+----+--------------------------------+
|    | Downsize operations      |    | Merge with other company       |
+----+--------------------------+----+--------------------------------+
|    | Expand operations        |    | Form a joint venture           |
+----+--------------------------+----+--------------------------------+
|    | Enter product trials     |    | Expand into foreign markets    |
+----+--------------------------+----+--------------------------------+
|    | Launch new product       |    | Outsource production           |
+----+--------------------------+----+--------------------------------+
|    | Acquire a company        |    | Establish facilities abroad    |
+----+--------------------------+----+--------------------------------+
|    | Recruit employees from   |    | No change                      |
|    | abroad                   |    |                                |
+----+--------------------------+----+--------------------------------+
|    | Increase recruitment     |    | Other (specify):               |
|    | efforts for U.S. workers |    |                                |
+----+--------------------------+----+--------------------------------+

+-----+----------------------------------------------------------------+
| 31) |                                                                |
|  Wh |                                                                |
| ich |                                                                |
|     |                                                                |
|  of |                                                                |
|     |                                                                |
|     |                                                                |
| the |                                                                |
|     |                                                                |
|     |                                                                |
| fol |                                                                |
| low |                                                                |
| ing |                                                                |
|     |                                                                |
|   s |                                                                |
| ele |                                                                |
| cti |                                                                |
| ons |                                                                |
|     |                                                                |
|   b |                                                                |
| est |                                                                |
|     |                                                                |
|     |                                                                |
| des |                                                                |
| cri |                                                                |
| bes |                                                                |
|     |                                                                |
|     |                                                                |
| the |                                                                |
|     |                                                                |
|  co |                                                                |
| mpe |                                                                |
| tit |                                                                |
| ive |                                                                |
|     |                                                                |
|     |                                                                |
| pro |                                                                |
| spe |                                                                |
| cts |                                                                |
|     |                                                                |
|     |                                                                |
| for |                                                                |
|     |                                                                |
|   y |                                                                |
| our |                                                                |
|     |                                                                |
|  bu |                                                                |
| sin |                                                                |
| ess |                                                                |
|     |                                                                |
|   o |                                                                |
| per |                                                                |
| ati |                                                                |
| ons |                                                                |
|     |                                                                |
|  in |                                                                |
|     |                                                                |
|     |                                                                |
| the |                                                                |
|     |                                                                |
|   n |                                                                |
| ext |                                                                |
|     |                                                                |
|     |                                                                |
| two |                                                                |
|     |                                                                |
|     |                                                                |
| yea |                                                                |
| rs? |                                                                |
+-----+----------------------------------------------------------------+
|     | Improve greatly                                                |
+-----+----------------------------------------------------------------+
|     | Improve somewhat                                               |
+-----+----------------------------------------------------------------+
|     | Remain stable                                                  |
+-----+----------------------------------------------------------------+
|     | Decline somewhat                                               |
+-----+----------------------------------------------------------------+
|     | Decline greatly                                                |
+-----+----------------------------------------------------------------+

+---------------------------------+------------------------------------+
| 32) How many United States      |                                    |
|     Patent and Trademark Office |                                    |
|     [current biotechnology      |                                    |
|     patents or patents          |                                    |
|     pending]{.underline} does   |                                    |
|     your firm have? (Indicate   |                                    |
|     zero if none)               |                                    |
+---------------------------------+------------------------------------+
| Current: \_\_\_\_\_\_\_\_\_\_   | Pending: \_\_\_\_\_\_\_\_\_\_      |
+---------------------------------+------------------------------------+

+------------+------------+--------------+------------+--------------+
| 33) During |            |              |            |              |
|            |            |              |            |              |
| 2000-2001, |            |              |            |              |
|     did    |            |              |            |              |
|     your   |            |              |            |              |
|     firm   |            |              |            |              |
|     grant  |            |              |            |              |
|     the    |            |              |            |              |
|     right  |            |              |            |              |
|     to use |            |              |            |              |
|     in     |            |              |            |              |
| tellectual |            |              |            |              |
|            |            |              |            |              |
|   property |            |              |            |              |
|     to     |            |              |            |              |
|            |            |              |            |              |
|    another |            |              |            |              |
|     firm   |            |              |            |              |
|     or did |            |              |            |              |
|     your   |            |              |            |              |
|     firm   |            |              |            |              |
|            |            |              |            |              |
|    acquire |            |              |            |              |
|     the    |            |              |            |              |
|     right  |            |              |            |              |
|     to use |            |              |            |              |
|     in     |            |              |            |              |
| tellectual |            |              |            |              |
|            |            |              |            |              |
|   property |            |              |            |              |
|     from   |            |              |            |              |
|            |            |              |            |              |
|    another |            |              |            |              |
|     firm?  |            |              |            |              |
|     If     |            |              |            |              |
|     "**[   |            |              |            |              |
| Yes]{.unde |            |              |            |              |
| rline}**," |            |              |            |              |
|     please |            |              |            |              |
|            |            |              |            |              |
|   indicate |            |              |            |              |
|     the    |            |              |            |              |
|     type   |            |              |            |              |
|     and    |            |              |            |              |
|            |            |              |            |              |
|  direction |            |              |            |              |
|     of     |            |              |            |              |
|     such   |            |              |            |              |
|     in     |            |              |            |              |
| tellectual |            |              |            |              |
|            |            |              |            |              |
|   property |            |              |            |              |
|            |            |              |            |              |
|  transfer: |            |              |            |              |
+------------+------------+--------------+------------+--------------+
| **In       | **Granted  | **Acquired   | **Granted  | **Acquired   |
| tellectual | Rights to  | Rights from  | Rights to  | Rights from  |
| Property** | *Domestic* | *Domestic*   | *Foreign*  | *Foreign*    |
|            | Firms**    | Firms**      | Firms**    | Firms**      |
+------------+------------+--------------+------------+--------------+
|            | **Yes**    | **Yes**      | **Yes**    | **Yes**      |
+------------+------------+--------------+------------+--------------+
| Trade      |            |              |            |              |
| Secrets    |            |              |            |              |
+------------+------------+--------------+------------+--------------+
| Patents    |            |              |            |              |
+------------+------------+--------------+------------+--------------+
| Plant      |            |              |            |              |
| Breeders'  |            |              |            |              |
| Rights     |            |              |            |              |
+------------+------------+--------------+------------+--------------+
| Other      |            |              |            |              |
| (Specify)  |            |              |            |              |
+------------+------------+--------------+------------+--------------+

+-----------------------------------------------------------------------+
| 34) List the countries of your top three [foreign                     |
|     competitors]{.underline}.                                         |
+-----------------------------------------------------------------------+
| 1-                                                                    |
+-----------------------------------------------------------------------+
| 2-                                                                    |
+-----------------------------------------------------------------------+
| 3-                                                                    |
+-----------------------------------------------------------------------+

+-------------------------------------------------+---+---+---+---+---+---+
| 35) Identify the barriers from the list below   |   |   |   |   |   |   |
|     that impede your firm's advancement of      |   |   |   |   |   |   |
|     biotechnology research or product           |   |   |   |   |   |   |
|     commercialization. For those impediments,   |   |   |   |   |   |   |
|     describe the degree of difficulty for that  |   |   |   |   |   |   |
|     barrier, with [1]{.underline} being no      |   |   |   |   |   |   |
|     barrier and [5]{.underline} being a high    |   |   |   |   |   |   |
|     barrier.                                    |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+
| **Barrier**                                     | * | * | * | * | * |   |
|                                                 | * | * | * | * | * |   |
|                                                 | 1 | 2 | 3 | 4 | 5 |   |
|                                                 | * | * | * | * | * |   |
|                                                 | * | * | * | * | * |   |
+-------------------------------------------------+---+---+---+---+---+---+
| Access to start-up capital                      |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+
| Access to technology                            |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+
| Access to information                           |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+
| Size of market                                  |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+
| Unfair foreign laws                             |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+
| Unfair U.S. laws                                |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+
| Access to international market                  |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+
| Export control regulations                      |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+
| Import regulations                              |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+
| Lack of qualified biotechnology employees       |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+
| Distribution and transportation costs           |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+
| Marketing costs                                 |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+
| Research costs                                  |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+
| Shortage of approved U.S. manufacturing         |   |   |   |   |   |   |
| facilities                                      |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+
| Patent fees and approval process                |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+
| Patent rights held by third parties             |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+
| Lack of patent protection abroad for            |   |   |   |   |   |   |
| product/process                                 |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+
| Lack of understanding or interest by U.S. govt. |   |   |   |   |   |   |
| policymakers                                    |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+
| Antiquated rules and regulations                |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+
| Transportation regulations (including hazardous |   |   |   |   |   |   |
| material handling regulations)                  |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+
| Regulatory approval process and costs           |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+
| Antitrust laws                                  |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+
| Liability concerns/Insurance costs              |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+
| Unfair competition                              |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+
| Government procurement practices/regulations    |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+
| Equipment shortage                              |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+
| Insufficient or unstable government funding for |   |   |   |   |   |   |
| R&D                                             |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+
| Construction delays                             |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+
| Public acceptance/Ethical considerations        |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+
| Local zoning and permitting practices           |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+
| Other (Specify)                                 |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+
| 36) What additional actions, policy changes,    |   |   |   |   |   |   |
|     regulatory reforms, or assistance could the |   |   |   |   |   |   |
|     Federal Government take to help your firm   |   |   |   |   |   |   |
|     improve competitiveness?                    |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+
|                                                 |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+
|                                                 |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+
|                                                 |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+
|                                                 |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+
|                                                 |   |   |   |   |   |   |
+-------------------------------------------------+---+---+---+---+---+---+

+----------------------------------------------------------+-----------+
| 37) Has your firm had a defense contract, as a prime or  | Yes No    |
|     sub-contractor, within the last five years? If No,   |           |
|     proceed to 45.                                       |           |
+----------------------------------------------------------+-----------+
| 38) If yes, does your firm sell this product to the      | Yes No    |
|     Department of Defense as a commercial or             |           |
|     non-developmental item?                              |           |
+----------------------------------------------------------+-----------+
| 39) Does your firm currently have a defense contract?    | Yes No    |
+----------------------------------------------------------+-----------+

+---+---+---------------------------------+---+--------------------+-----------+
| 4 |   |                                 |   |                    | Yes No    |
| 0 |   |                                 |   |                    |           |
| ) |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
| I |   |                                 |   |                    |           |
| n |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
| t |   |                                 |   |                    |           |
| h |   |                                 |   |                    |           |
| e |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
| l |   |                                 |   |                    |           |
| a |   |                                 |   |                    |           |
| s |   |                                 |   |                    |           |
| t |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
| f |   |                                 |   |                    |           |
| i |   |                                 |   |                    |           |
| v |   |                                 |   |                    |           |
| e |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
| y |   |                                 |   |                    |           |
| e |   |                                 |   |                    |           |
| a |   |                                 |   |                    |           |
| r |   |                                 |   |                    |           |
| s |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
| h |   |                                 |   |                    |           |
| a |   |                                 |   |                    |           |
| s |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
| y |   |                                 |   |                    |           |
| o |   |                                 |   |                    |           |
| u |   |                                 |   |                    |           |
| r |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
| f |   |                                 |   |                    |           |
| i |   |                                 |   |                    |           |
| r |   |                                 |   |                    |           |
| m |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
| e |   |                                 |   |                    |           |
| x |   |                                 |   |                    |           |
| i |   |                                 |   |                    |           |
| t |   |                                 |   |                    |           |
| e |   |                                 |   |                    |           |
| d |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
| t |   |                                 |   |                    |           |
| h |   |                                 |   |                    |           |
| e |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
| d |   |                                 |   |                    |           |
| e |   |                                 |   |                    |           |
| f |   |                                 |   |                    |           |
| e |   |                                 |   |                    |           |
| n |   |                                 |   |                    |           |
| s |   |                                 |   |                    |           |
| e |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
|   |   |                                 |   |                    |           |
| m |   |                                 |   |                    |           |
| a |   |                                 |   |                    |           |
| r |   |                                 |   |                    |           |
| k |   |                                 |   |                    |           |
| e |   |                                 |   |                    |           |
| t |   |                                 |   |                    |           |
| ? |   |                                 |   |                    |           |
+---+---+---------------------------------+---+--------------------+-----------+
| I |   |                                 |   |                    |           |
| f |   |                                 |   |                    |           |
| * |   |                                 |   |                    |           |
| * |   |                                 |   |                    |           |
| [ |   |                                 |   |                    |           |
| y |   |                                 |   |                    |           |
| e |   |                                 |   |                    |           |
| s |   |                                 |   |                    |           |
| ] |   |                                 |   |                    |           |
| { |   |                                 |   |                    |           |
| . |   |                                 |   |                    |           |
| u |   |                                 |   |                    |           |
| n |   |                                 |   |                    |           |
| d |   |                                 |   |                    |           |
| e |   |                                 |   |                    |           |
| r |   |                                 |   |                    |           |
| l |   |                                 |   |                    |           |
| i |   |                                 |   |                    |           |
| n |   |                                 |   |                    |           |
| e |   |                                 |   |                    |           |
| } |   |                                 |   |                    |           |
| * |   |                                 |   |                    |           |
| * |   |                                 |   |                    |           |
| , |   |                                 |   |                    |           |
| f |   |                                 |   |                    |           |
| o |   |                                 |   |                    |           |
| r |   |                                 |   |                    |           |
| w |   |                                 |   |                    |           |
| h |   |                                 |   |                    |           |
| i |   |                                 |   |                    |           |
| c |   |                                 |   |                    |           |
| h |   |                                 |   |                    |           |
| o |   |                                 |   |                    |           |
| f |   |                                 |   |                    |           |
| t |   |                                 |   |                    |           |
| h |   |                                 |   |                    |           |
| e |   |                                 |   |                    |           |
| f |   |                                 |   |                    |           |
| o |   |                                 |   |                    |           |
| l |   |                                 |   |                    |           |
| l |   |                                 |   |                    |           |
| o |   |                                 |   |                    |           |
| w |   |                                 |   |                    |           |
| i |   |                                 |   |                    |           |
| n |   |                                 |   |                    |           |
| g |   |                                 |   |                    |           |
| r |   |                                 |   |                    |           |
| e |   |                                 |   |                    |           |
| a |   |                                 |   |                    |           |
| s |   |                                 |   |                    |           |
| o |   |                                 |   |                    |           |
| n |   |                                 |   |                    |           |
| s |   |                                 |   |                    |           |
| ? |   |                                 |   |                    |           |
| ( |   |                                 |   |                    |           |
| s |   |                                 |   |                    |           |
| e |   |                                 |   |                    |           |
| l |   |                                 |   |                    |           |
| e |   |                                 |   |                    |           |
| c |   |                                 |   |                    |           |
| t |   |                                 |   |                    |           |
| a |   |                                 |   |                    |           |
| l |   |                                 |   |                    |           |
| l |   |                                 |   |                    |           |
| t |   |                                 |   |                    |           |
| h |   |                                 |   |                    |           |
| a |   |                                 |   |                    |           |
| t |   |                                 |   |                    |           |
| a |   |                                 |   |                    |           |
| p |   |                                 |   |                    |           |
| p |   |                                 |   |                    |           |
| l |   |                                 |   |                    |           |
| y |   |                                 |   |                    |           |
| ) |   |                                 |   |                    |           |
+---+---+---------------------------------+---+--------------------+-----------+
|   | > |                                 | > |                    |           |
|   | > |                                 | > |                    |           |
|   |   |                                 |   |                    |           |
|   | I |                                 | C |                    |           |
|   | n |                                 | o |                    |           |
|   | c |                                 | m |                    |           |
|   | o |                                 | m |                    |           |
|   | n |                                 | e |                    |           |
|   | s |                                 | r |                    |           |
|   | i |                                 | c |                    |           |
|   | s |                                 | i |                    |           |
|   | t |                                 | a |                    |           |
|   | e |                                 | l |                    |           |
|   | n |                                 | > |                    |           |
|   | t |                                 |   |                    |           |
|   | > |                                 | m |                    |           |
|   |   |                                 | a |                    |           |
|   | p |                                 | r |                    |           |
|   | r |                                 | k |                    |           |
|   | o |                                 | e |                    |           |
|   | c |                                 | t |                    |           |
|   | u |                                 | > |                    |           |
|   | r |                                 |   |                    |           |
|   | e |                                 | m |                    |           |
|   | m |                                 | o |                    |           |
|   | e |                                 | r |                    |           |
|   | n |                                 | e |                    |           |
|   | t |                                 | > |                    |           |
|   | > |                                 |   |                    |           |
|   |   |                                 | p |                    |           |
|   | p |                                 | r |                    |           |
|   | r |                                 | o |                    |           |
|   | a |                                 | f |                    |           |
|   | c |                                 | i |                    |           |
|   | t |                                 | t |                    |           |
|   | i |                                 | a |                    |           |
|   | c |                                 | b |                    |           |
|   | e |                                 | l |                    |           |
|   | s |                                 | e |                    |           |
+---+---+---------------------------------+---+--------------------+-----------+
|   |   | > Decrease in defense demand    |   | > Delays in        |           |
|   |   |                                 |   | > payment          |           |
+---+---+---------------------------------+---+--------------------+-----------+
|   |   | > Department of Defense         |   | > Onerous          |           |
|   |   | > regulations too cumbersome    |   | > compliance with  |           |
|   |   |                                 |   | > the Federal      |           |
|   |   |                                 |   | > Acquisition      |           |
|   |   |                                 |   | > Regulations      |           |
+---+---+---------------------------------+---+--------------------+-----------+
|   |   | > Sold defense portion of       |   | > Other (specify)  |           |
|   |   | > business                      |   |                    |           |
+---+---+---------------------------------+---+--------------------+-----------+
|   |   | > Merger/Acquisition            |   |                    |           |
+---+---+---------------------------------+---+--------------------+-----------+

+-----------------------------------------------------------------------+
| # Part vi -- Certification                                            |
+-----------------------------------------------------------------------+

The undersigned certifies that the information herein supplied in
response to this questionnaire is complete and correct to the best of
his/her knowledge. It is a criminal offense to willfully make a false
statement or representation to any department or agency of the United
States Government as to any matter within its jurisdiction. (18 U.S.C.A.
1001 (1984 & SUPP. 1197))

\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_

Company Name

\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_

Authorizing Official -- Print Name

\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_ \_\_\_\_\_\_\_\_\_\_\_\_
\_\_\_\_\_

Title Phone Number Ext.

\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
\_\_\_\_\_\_\_\_\_

Signature Date

\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_

Point of Contact- Print Name Title

\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_ \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
\_\_\_\_\_\_

> Email Phone Number Ext.

  -----------------------------------------------------------------------
  [Comments]{.underline} (optional): In the space below, provide any
  additional comments or any other information you wish to include
  regarding your biotechnology operations or other related issues that
  impact your firm. In addition, what industry needs and concerns did
  this survey fail to address?

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