Curriculum Vitae

[Personal Data]{.underline} Katrina L. Mealey

Department of Veterinary Clinical Sciences

College of Veterinary Medicine

Washington State University

Pullman, WA 99164-6610

Birthdate/place .........................

Marital Status ..........................

[Education]{.underline} Undergraduate: B. S. (Pharmacy); University of
New Mexico, 1986

Professional: D.V.M.; Colorado State University, 1990

Graduate: Ph.D.; Texas A&M University, 1998

[Professional Training]{.underline}

Internship: Small Animal Medicine and Surgery; University of Minnesota,
1990-1991

Residency: Texas A & M University, 1991-1994

> Board Certification: Diplomate, American College of Veterinary
> Clinical Pharmacology Diplomate, American College of Veterinary
> Internal Medicine (Small Animal Internal Medicine)

[Employment]{.underline}

Assistant Professor, Washington State University, August 1998-present

Adjunct Assistant Professor, Washington State University, October
1997-August 1998

Research Associate, Washington State University, September 1996-1997

Assistant Research Scientist, Texas A&M University, August 1994-August
1996

Veterinary Clinical Associate, College of Veterinary Medicine, TAMU;
July 1994-July 1995

Residency in Clinical Pharmacology, Texas A & M University; July
1991-July 1994

Internship in Small Animal Medicine and Surgery, University of
Minnesota; 1990-1991

Pharmacist (part-time), Colorado State University, Fort Collins
CO;1986-90

Pharmacist (fill-in), Burke\'s Pharmacy, Albuquerque, NM; 1986-1989

Pharmacy Intern, New Mexico Poison Center, UNM Hospital and Trauma
Center; 1984-1986

[Honors and Awards]{.underline}

Wescott Clinical Teaching Scholar, 1999

Phi Zeta (Eta Chapter) Research Manuscript Award, 1998

College of Veterinary Medicine Graduate Student Travel Award, 1996

National Cancer Institute Physician Scientist Award; 1995

Phi Zeta (Veterinary Honor Society); 1995

Hoechst-Rousel Graduate Student Travel Award; 1994

Merck Foundation Resident in Veterinary Clinical Pharmacology; 1991-1994

Rho Chi (National Honor Society, Colleges of Pharmacy); 1985-1986

Eli Lilly Award (Scholarship, Ethics and Leadership); 1986

Who\'s Who Among America\'s Colleges and Universities; 1985

Most Distinguished Presidential Scholar; 1986

[Research Support]{.underline}

Winn Feline Foundation, 2001-2002

Bioavailability of Topically Administered Drugs in Cats; .......

> Role: Principal Investigator

National Cancer Institute Mentored Clinical Scientist Award, 1999-2001

> Role of Glucocorticoids in Regulating MRP Expression; ......\...
>
> Role: Principal Investigator; Howard Hosick, sponsor

American Cancer Society Institutional (WSU) Grant, 1998

> Characterization of the *MDR*1 Gene in an Intermediate Tumor Model
> ........
>
> Role: Principal Investigator

National Cancer Institute Physician Scientist Award, 1995-1998

> Novel Approaches to MDR Induction and Modulation; ......\...
>
> Role: Principal Investigator; Steve Safe, sponsor

Texas A&M University, College of Veterinary Medicine OSP Intramural
Grant, 1995

> Role of Calcineurin in P-glycoprotein-mediated MDR ...\...
>
> Role: Principal Investigator

Texas A&M University, College of Veterinary Medicine Graduate Student
Minigrant, 1994

> Novel Approaches to Induction and Modulation of P-glycoprotein ...\...
>
> Role: Principal Investigator

[Publications and Abstracts]{.underline}

[Refereed]{.underline}

Mealey KL, Bentjen SA. Sequence and structural analysis of the
downstream promoter of the canine mdr1 gene, *Veterinary Pathology*,
submitted.

Mealey KL, Bentjen SA, Gay JM, Hosick HL. Dexamethasone treatment of
canine osteosarcoma cells increases chemoresistance independent of
P-glycoprotein and MRP expression, *Cancer Chemotherapy and
Pharmacology*, submitted.

Fransson B, Peck K, Mealey KL. Pharmacokinetics of topically applied
liposome-encapsulated lidocaine gel in cats, *American Journal of
Veterinary Research*, accepted.

Fransson B, Mealey KL, Dutta S. Clozapine intoxication in a dog.
*Journal of the American Animal Hostpital Association*, accepted.

Shinozaki JK, Cantor GH, Besser TE, Mealey KL, Vaden SL, Sellon RK.
Fecal polymerase chain reaction using 16S primers can detect intestinal,
but not gastric, *Helicobacter* in dogs. *Journal of Veterinary Internal
Medicine,* accepted.

Mealey KL, Bentjen SA, Waiting D. Frequency of the mutant MDR1 allele
associated with ivermectin sensitivity in a sample population of Collies
from the northwestern United States. *American Journal of Veterinary
Research*, 2002;63:479-481.

Lahmers S, Mealey KL, Martinez S, Sellon RK, Halderson GJ, Cambridge AJ.
Synovial T-cell lymphoma of the stifle in a dog. *Journal of the
American* *Animal Hospital Association*, 2002; 38:165-168.

Mealey KL, Barhoumi R, Burghardt B, Safe S, Kochevar DT. Doxycycline
induces expression of P-glycoprotein as effectively as doxorubicin in
MCF-7 breast carcinoma cells. *Antimicrobial Agents and Chemotherapy*,
2002;46:755-761.

Mealey KL. Clinically significant drug interactions. *Compendium of
Continuing Education for Practicing Veterinarians*, 2002; 24:10-22.

Peck K, Matthews NS, Taylor T, Mealey KL. Comparative pharmacokinetics
of trimethoprim and sulfamethoxazole in horses, donkeys, and mules.
*American Journal of Veterinary Research*, 2002;63:349-353.

Mealey KL, Bentjen SA, Gay J, Cantor GH. Ivermectin sensitivity in
Collies is associated with a deletion mutation of the mdr1 gene*.
Pharmacogenetic*s, 2001;11:727-733.

Hofmeister E, Kippenes K, Mealey KL (corresponding author), Cantor G.
Functional giant thyroid cyst in a cat. *Journal of the* *American
Veterinary Medical Association*, 2001;219:190-193.

Mealey KL. Beta-lactamase inhibitors. *Journal of the American
Veterinary Medical Association*, 2001;218:1893-1896.

Peck K, Hines MT, Mealey KL (corresponding author), Mealey RH.
Pharmacokinetics of imipramine in narcoleptic horses. *American Journal
of Veterinary Research*, 2001;62:783-786.

Matthews NS, Peck KE, Taylor TS, Mealey KL. Pharmacokinetics of
phenylbutazone and its major metabolite, oxyphenbutazone in miniature
donkeys, *American Journal of Veterinary Research*, 2001;62:673-675.

Mealey KL. Systemic absorption of topically administered drugs.
*Compendium of Continuing Education for Practicing Veterinarians,* 2000;
22:649-657.

Mealey KL, Barhoumi R, Burghardt RC, McIntyre BS, Sylvester PW, Hosick
HL, Kochevar DT. Immunosuppressant inhibition of P-glycoprotein function
is independent of drug-induced suppression of peptide-prolyl isomerase
and calcineurin activity. *Cancer Chemotherapy and Pharmacology* 1999;
44:152-158.

Coakley M, Peck KE, Taylor TS, Matthews NS, Mealey KL. Pharmacokinetics
of flunixin meglumine in donkeys, mules, and horses. *American Journal
of Veterinary Research* 1999;60:1441-1444.

Mealey KL, Willard M, Nagode, L, Helman HG. Hypercalcemia associated
with granulomatous disease in a cat. *Journal of the American Veterinary
Medical Association* 1999; 215:959-962.

Mealey KL, Matthews NS. Drug interactions in anesthesia. *Veterinary
Clinics of North America; Small Animal Practice* 1999;29:629-643.

Mealey KL, Barhoumi R, Rogers K, Kochevar DT. Doxorubicin induced
expression of P-glycoprotein in a canine osteosarcoma cell line. *Cancer
Letters* 1998; 126:187-192.

Martinez EA, Woolridge AA, Hartsfield SM, Mealey KL. Neuromuscular
effects of doxacurium chloride in isoflurane-anesthetized dogs.
*Veterinary Surgery 1998*;27:279-283.

Kochevar DT and Mealey KL. Principles of cancer chemotherapy.
*Veterinary Medicine*. 1997;92:336-349.

Peck K, Mealey KL, Matthews NS, Taylor TS. Comparative pharmacokinetics
of caffeine and three metabolites in clinically normal horses and
donkeys. *American Journal of Veterinary Research*. 1997;58:881-883.

Matthews NS, Peck KE, Mealey KL, Taylor TS. Pharmacokinetics and
cardiopulmonary effects of guaifenesin in donkeys. *Journal of
Veterinary Pharmacology and Therapeutics* 1997; 20:442-446.

Martinez EA, Mealey KL,Woolridge AA, et al. Pharmacokinetics, effects on
renal function, and potentiation of atracurium-induced neuromuscular
blockade after administration of a high dose of gentamicin in
isoflurane-anesthetized dogs. *American Journal of Veterinary Research.*
1996;57:1623-1630.

Mealey KL, Matthews NS, Peck KE, Ray AC, Taylor TS. Comparative
pharmacokinetics of phenylbutazone and its metabolite oxyphenbutazone in
clinically normal horses and donkeys. *American Journal of Veterinary
Research.* 1996;58:53-55.

Welfare RE, Mealey KL, Matthews NS and Taylor TS. Pharmacokinetics of
gentamicin in donkeys. *Journal of Veterinary Pharmacology and
Therapeutics*. 1996;19:167-170.

Kochevar DT, Middendorf D, Mealey KL, et al. Pharmacokinetics and
haematological effects of a single intravenous dose of mitoxantrone in
cats. *Journal of Veterinary Pharmacology and Therapeutics*
1995;18:471-475.

Mealey KL, Boothe DM. Bioavailability of benzodiazepines following
rectal administration of diazepam in dogs. *Journal of Veterinary
Pharmacology and Therapeutics*. 1995;18:72-74.

Miller SM, Matthews NS, Mealey KL, et al. Pharmacokinetics of gentamicin
in mammoth asses. *Journal of Veterinary Pharmacology and Therapeutics*.
1994;17:403-406.

Mealey KL, Boothe DM. Nephrotoxicosis associated with topical
administration of gentamicin in a cat. *Journal of the American
Veterinary Medical Association* 1994;204:1919-1921.

## Non-refereed

Mealey KL. Body surface area: Historical justifications, limitations,
and alternatives. *Veterinary Cancer Society Newsletter 1993*
17(3):12-15.

Mealey KL, Boothe DM. Use of glucocorticoids in the dog and cat.
*Veterinary Learning Systems Clinical Classroom, Continuing Education*,
1995.

Mealey KL. Invited commentary: Administration of diazepam rectally.
*Advances in Small Animal Medicine and Surgery* 1995 8(8):6.

## Book Chapters

Boothe DM, Mealey KL. Glucocorticoid therapy in the dog and cat. In: DM
Boothe (ed.) *Small Animal Clinical Pharmacology and Therapeutics*. WB
Saunders, Philadelphia, pp313-329, 2000.

Martinez EA, Mealey KL. Muscle relaxants. In: DM Boothe (ed) *Small
Animal Clinical Pharmacology and Therapeutics*. WB Saunders,
Philadelphia, pp473-481, 2000.

Kochevar DT, Mealey KL. Antineoplastic Agents. Merck Veterinary Manual,
8th edition; National Publishing, Inc., Philadelphia, 1998.

## Abstracts

Mealey KL. Doxorubicin does not increase MRP expression in canine
osteosarcoma cells. *Proceedings, Veterinary Cancer Society, October,*
2000*.*

Mealey KL, Bentjen S, Cantor G. Canine MDR1 promoter. *Proceedings,
American College of Veteirnary Internal Medicine*, 2000.

Shinozaki J, Cantor G, Besser T, Mealey K, Vaden S, Sellon RK. Fecal PCR
identifies intestinal but not gastric Helicobacter in dogs.
*Proceedings, American College of Veteirnary Internal Medicine*, 2000.

Matthews NS, Keck K, Taylor T, Mealey KL. Pharmacokinetics of
phenylbutazone in miniature donkeys. *Proceedings, American College of
Veterinary Anesthesiology*, *2000*.

Mealey KL, Barhoumi R, Burghardt RC, McIntyre BS, Sylvester PW, Hosick
HL, Kochevar DT. Immunosuppressant inhibition of P-glycoprotein function
is independent of drug-induced suppression of peptide-prolyl isomerase
and calcineurin activity. *Proceedings of American Association for
Cancer Research, 38, 1998*

Mealey KL, Barhoumi R, Burghardt R, Safe S, Kochevar DT. Doxycycline
induces expression of P-glycoprotein as effectively as doxorubicin in
MCF-7 breast carcinoma cells. *Proceedings of the American Association
for Cancer Research*, 38, 1997.

Matthews NS, Mealey KL, Peck K. Comparative pharmacokinetics of caffeine
and metabolites in horses and donkeys. *Proceedings, American College of
Veterinary Anesthesiology*, 1997.

Peck K, Mealey KL, Matthews NS. Comparative pharmacokinetics of
guaifenesin in horses and donkeys. *Proceedings, American College of
Veterinary Anesthesiology*, 1997

Martinez E, Hartsfield S, Mealey KL. Neuromuscular effects of doxacurium
chloride in isoflurane-anesthetized dogs. *Proceedings, American College
of Veterinary Anesthesiology*, 1997.

Mealey KL, Barhoumi R, Burghardt R, Kochevar DT. Can drugs other than
antineoplastic agents induce multidrug resistance? *Proceedings,
Veterinary Cancer Society, 1997*

Mealey KL, Botos JJ, Barton CL, Kochevar DT. Doxorubicin-induced
expression of P-glycoprotein in a canine osteosarcoma cell line.
*Proceedings, American College of Veterinary Internal Medicine,* 1996.

Mealey KL, Barhoumi R, Rogers KS, Kochevar DT. Induction of
P-glycoprotein mediated multiple drug resistance in a canine
osteosarcoma cell line. *Proceedings, Veterinary Cancer Society, 1996*.

Mealey KL, Silva EG, Kochevar DT. Heat shock protein expression in
doxorubicin-treated MCF-7 breast cancer cells. *Proceedings, College of
Veterinary Medicine Graduate Student Association*, 1995 pp4.

Martinez E, Mealey KL, Effect of a single daily dose of gentamicin on
neuromuscular blockade induced by atracurium in isoflurane-anesthetized
dogs. *Proceedings, American College of Veterinary Anesthesiology*,
1995.

Mealey KL, Kochevar DT. Pharmacologic reversal of multiple drug
resistance (MDR) in a human breast cancer cell line: proposed role of
calcineurin. *Proceedings, Eighth Annual Graduate Research Symposium
(Baylor College of Medicine and Texas A&M University)*, 1995.

Matthews NS, Mealey KL, Peck KE, Taylor TS, Ray AC. Pharmacokinetics of
phenylbutazone in donkeys:Comparison to the horse.
*Proceedings,AmericanCollege of VeterinaryAnesthesiology*, 1995.

Matthews NS, Peck KE, Mealey KL, Taylor TS, Ray AC. Pharmacokinetics and
pharmacodynamics of guaifenesin in donkeys. *Proceedings, American
College of Veterinary Anesthesiology*, 1995.

Matthews NS, Taylor TS, Mealey KL,et al.Pharmacokinetics of gentamicin,
ketamine, and phenylbutazone in donkeys, mules, mammoth asses.
*Proceedings of Second International Colloquium on Working Equines,*
1994 pp5.

Miller SM, Matthews NS, Mealey KL, et al. Pharmacokinetics of gentamicin
in mammoth asses. *Proceedings of the World Equine Veterinary
Association Congress,* 1993 pp192.

[Teaching]{.underline}

[COURSE/TITLE]{.underline}

VM 522 (WSU) Small Animal Medicine II, 11 hours, Fall semester, 2000

VM 522 (WSU) Pharmacology; 1 hour, Fall semester, 2000

Gen/CB 572 (WSU) Fundamentals of Oncology; Fall semester 2000

VM 521 (WSU) Small Animal Medicine I, 5 hours, Spring semester, 2000

VM 522 (WSU) Small Animal Medicine II, 10 hours, Fall semester, 1999

VM 521 (WSU) Small Animal Medicine I, 4 hours, Spring semester, 1999

VM 522 (WSU) Pharmacology; 1 hour, Fall semester, 1998

VM 552 (WSU) Small Animal Medicine II, 13 hours, Fall semester, 1998

VM 522 (WSU) Pharmacology; 2 hours, Fall semester 1997

VMID 912 (TAMU) Clinical Correlations; 8 hours Fall semester 1995

VTPP 924 (TAMU) Pharmacology; 1 hour Fall semester 1995

VTPP 924L (TAMU) Pharmacology Lab; 8 hours Fall semester 1995

VMID 912 (TAMU) Clinical Correlations; 8 hours Spring semester 1995

VTPP 925 (TAMU) Pharmacology; 2 hours Spring semester; 1993-5

VTPP 924L(TAMU) Pharmacology Lab; 3 hours/semester; 1991-1995

VTPP 925L (TAMU) Pharmacology Lab;6 hours/semester; 1991-1995

VMID 951 (TAMU) Physical Diagnosis; 6 hours/semester; 1991-1994

Fourth year (TAMU; University of Minnesota) Clinical Rotations;
1990-1994

Pharmacy 486 (Compounding Lab, U.N.M.); 3 hours/week 1985-1986

[Continuing Education]{.underline}

Wild West Veterinary Conference 11 hours

ACVIM 2001

WSU Spring Conference (

WSU Boise CE Conference (3 hours), Boise, ID, 2001

Calgary Veterinary CE Conference (6 hours), Calgary, Alberta, Canada,
2001

Clinical Pharmacology (1.5 hours) WSU Spring Conference, Pullman, WA,
2000

Endocrinology (6 hours) WSU Spring Conference, Pullman, WA, 2000

Internal Medicine (6 hours) Okanagan Veterinary Medical Association,
Kelowna, British Columbia, Canada, 2000

Clinical Pharmacology (9 hours) Arizona Veterinary Medical Association,
Phoenix, Arizona, 2000

Clinical Pharmacology (6 hours) WSVMA Annual Conference, Yakima, WA,
1999

Respiratory Diseases (6 hours) WSU Spring Conference, Pullman, WA, 1999

Clinical Pharmacology (6 hours) Western States Veterinary Conference,
Las Vegas, Nevada, 1998

Topical Drug Administration: Texas Veterinary Medical Association Summer
Showcase, 1995

Basic Principles in Pharmacology: Texas Veterinary Technicians
Association, 1995

Analgesics: Brazos County Veterinary Medical Association, 1995

Pharmacology Update: Texas Veterinary Medical Association Summer
Showcase, 1994

[Professional Organizations]{.underline}

American College of Veterinary Internal Medicine; 1999-present

American Association for Cancer Research; 1995-present

Veterinary Cancer Society; 1994-present

American College of Veterinary Clinical Pharmacology; 1995-present

American Veterinary Medical Association; 1990-present

# Scientific Review

United States Pharmacopeia Drug Information (USPDI) monographs
(Veterinary)---Glucocorticoids; 1998-present

American Journal of Veterinary Research-Ad hoc reviewer

1999-2 manuscripts

2000-1 manuscript

Journal of the American Veterinary Medical Association-Ad hoc reviewer

1999-1 manuscript

2000-1 manuscript

[Service]{.underline}

Departmental (2000)

Search Committees

> WSU Department of Veterinary Clinical Sciences: Department Chair,
> Small Animal Surgeon
>
> WSU Department of Veterinary Comparative Anatomy, Physiology and
> Pharmacology: Muscle Molecular Biologist
>
> WSU Vetstar Ad Hoc Committee
>
> WSU DIRC Committee
>
> Research Committee

Departmental (1999)

Search Committees

> WSU Department of Veterinary Clinical Sciences: Department Chair,
> Small Animal Surgeon
>
> WSU Department of Veterinary Comparative Anatomy, Physiology and
> Pharmacology: Muscle Molecular Biologist

Departmental (1995-1996)

Pharmacy and Therapeutics Committee (Texas A&M University)

College (2000)

Curriculum Committee (WSU)

College (1999)

Curriculum Committee (WSU)

National (2000)

Examination Committee, American College of Veterinary Clinical
Pharmacology

Credentials Committee, American College of Veterinary Internal Medicine

National (1999)

Examination Committee, American College of Veterinary Clinical
Pharmacology

American Association for Cancer Research, Associate Member Council
(Co-chairman)

National (1995-1998)

Credentials Committee, American College of Veterinary Clinical
Pharmacology

Examination Appeals Ad Hoc Committee, ACVCP (1997)