**Screening and Outcomes in Biliary Atresia**

**Sponsored by NIDDK, HRSA, ORD**

**September 11-12, 2006**

**Aims:** To assess current knowledge of the pathogenesis, clinical
presentation, natural history, surgery and outcomes of biliary atresia
in the United States and elsewhere focusing upon the role of newborn
screening and means of early detection of biliary atresia and the
evidence for and against the effectiveness and the medical outcomes of
methods of screening. The meeting will also review the current
understanding of the pathogenesis of biliary atresia and possibility of
new approaches to early detection using a better understanding of its
pathogenesis and clinical course.

**Organizers**: Ronald Sokol (U Colorado), Ross Shepherd (Washington U),
Riccardo Superina (Children's Hospital, Chicago), Patricia Robuck
(NIDDK), Jay Hoofnagle (NIDDK), Stephen Groft (ORD), Marie Mann (HRSA),
Diane Sumner (CLASS) and Ellis Green (ALF)

**Tentative Agenda**

**Day One: Monday, September 11, 2006**

8:00-8:15 am Welcome & Introduction. Ronald Sokol (U Colorado)

**Session 1: Clinical Course of Biliary Atresia**

8:15-8:35 Neonatal jaundice. Jeff Maisels (Wm Beaumont, Michigan)

8:35-8:55 Epidemiology and clinical features. Barbara Haber (CHOP)

8:55-9:15 Diagnosis. Peter Whitington (Children's Memorial, Chicago)

9:15-9:35 Pathology. Pierre Russo (CHOP)

9:30-10:00 Discussion

10:00-10:20 Break

**Session 2: Hepatoporto-enterostomy and Outcomes for Biliary Atresia**

10:20-10:40 The Kasai Procedure. Riccardo Superina (Children's Memorial
Chicago)

10:40-11:00 Outcomes in the US. Ben Shneider (Mt Sinai, NY)

11:00-11:20 Outcomes in Canada. Richard Schreiber (UBC, Canada)

11:20-11:40 Outcomes in the UK. Mark Davenport (Kings, London)

11:40-12:00 Outcomes in France. Christophe Chardot. (Geneva,
Switzerland)

12:00-12:30 Discussion

12:30-1:30 Lunch

**Day One: Afternoon**

**Session 3: Biliary Atresia: New Insights into Etiology**

1:30-1:50 Developmental biology of the biliary tract. Michael Pack (U
Penn)

1:50-2:10 Viral & Immunological Pathogenesis. Cara Mack (U Colorado)

2:10-2:30 Genetics of Biliary Atresia. David Perlmutter (U Pittsburgh)

2:30-2:50 Proteomics and biomarkers. Robert Heuckeroth (Wash U, St
Louis)

2:50-3:10 Discussion

3:10-3:40 Break

**Session 4: Towards improving outcomes of Biliary Atresia**

3:40-4:00 Obstacles to making an early diagnosis (Ron Sokol, U Colorado)

4:00-4:20 Corticosteroids after HPE (Masaki Nio, Sendai, Japan)

4:20-4:40 Nutritional Aspects (Ross Shepherd, Wash U) \[Y\]

4:40-5:00 Neurodevelopmental Outcomes (Estella Alonso, Children's
Chicago)

5:00-5:30 Discussion

5:30-7:00 Reception & Posters.

7:00-8:30 Dinner

**Day Two: Tuesday, September 12, 2006**

**Session 5: Early diagnosis and Screening for Biliary Atresia**

8:30-8:50 Current Status of Newborn Screening. Brad Therrell (U Texas,
Austin)

8:50-9:10 Use of serum & urinary bile acids. Jorge Bezerra (U Cinn)

9:10-9:30 Serum bilirubin. Deirdre Kelly (Birmingham, UK)

9:30-10:15 Stool Color Cards. Experience from Three Countries

> Akira Matsui (Jichi Univ, Japan)

Mei-Hwei Chang (Taiwan)

> Margaret Ramonet (Argentina)

10:15-10:45 Discussion/Break

**Session 6: Research Agenda for the Future**

10:45-12:00 Research Agenda summary. Organizers