**NIR breast cancer study(Case I)**

**Patient medical history:** A 31-year-old pre-menopausal female felt a
palpable lump in the upper quadrant of her left breast. Her baseline
mammogram was performed on 11-08-05, HUP's outside review of her films
identified the palpable area along with a tiny cluster of
calcifications.

A left breast core biopsy was performed on 11/11/2005, HUP's review of
outside pathology slides states "invasive poorly differentiated ductal
carcinoma with associated intraductal carcinoma..."

**NIR Device I**

![](media/image1.png){width="2.0069444444444446in"
height="1.9680555555555554in"} ![](media/image2.png){width="1.4in"
height="1.5708333333333333in"}

**Experimental Procedure and results**

Scanner: Holding the scanner by hand, scanning from one side to the
other side on both breasts. Red light on means touching the edge of the
tumor, green light on later means leaving the edge of tumor in the other
side.

> ![](media/image3.jpeg){width="4.054724409448819in"
> height="2.6236220472440945in"}

Fig. 3 Scanner showing

**Conclusion:** Right breast has no NIR signal; Left breast has NIR
signal at 1:00 as shown on Fig.3.

**NIR device 2(Puck):**

Basic method: Divided the breast into four quadrants:

![](media/image4.png){width="2.923611111111111in" height="2.03125in"}

![](media/image5.jpeg){width="3.9429133858267718in"
height="3.141732283464567in"}

Fig. 5 LED imaging

![](media/image6.wmf){width="5.0e-2in" height="5.0e-2in"}**Results:**

***[The puck size is 3cm radius big. The breast size is 4cm radius
maximum from the edge of nipple in supine position. So, put the probe on
the nipple to cover the whole breast.]{.underline}***

On the Left breast Upper outer Quadrant

![](media/image7.jpeg){width="2.9298611111111112in"
height="2.026388888888889in"}

Left breast up inner quadrant, D2 has 3uM blood volume and -53%
oxygenation.

Results fit to the published chart:

![](media/image9.png){width="5.982638888888889in"
height="3.9805555555555556in"}

L-left breast; R-right breast; L-leipzig

A two-dimensional nomogram display of currently available NIR breast
cancer data. The abscissa is relative increments of blood concentration
in units of micromolar concentration change with respect to the average
cancer-free value. The ordinate represents incremental change with
respect to the average cancer-free value in percent change of hemoglobin
saturation. The reference values (zero for saturations and blood
volumes) are based on the contralateral cancer-free breast as
represented by a congruence. The wavelengths are at 760 and 850 nm, and
the incremental concentrations are appropriately processed for the
weighted sum and difference quantities for blood concentration and
saturation change, respectively, with 70% and 50 μM the reference points
(0) for the two metrics. The data cover studies from 1997 to 2003.
Verified cancers are indicated with a black dot and cancer-free breasts
plotted with an X. Data from Leipzig are marked L, data from
Philadelphia are not marked. The nomogram is divided into two parts, one
containing the verified cancers (I) and the other containing the
cancer-free breasts (II).

Red dot is from Fig. 6 which is suspicious lesion. It is on the left
breast(L) 2:00, in zone I.