[Usage Notes Pertaining to P1-P2 Analysis File]{.underline}

1.0 Introduction

AHS analytical data files have been prepared that incorporate the
pesticide exposure information obtained during the Phase 2 interviews,
demographic variables and the current cancer incidence data with follow
up through December 31, 2005. The analytical file contains records for
all private (n=52,393) and commercial applicators (n=4,916) for which
follow-up is currently being conducted, whether or not they participated
in the Phase 2 interview. An indicator variable (PH2) for a completed
Phase 2 interview is included for each applicator.

The analytical file contains both lifetime days and lifetime intensity
days of use for 50 specific pesticides from the enrollment
questionnaire. The lifetime intensity days are calculated based on the
Version 2 algorithm intensity scores. Version 2 algorithm intensity
scores were calculated for both Phase 1 based on enrollment
questionnaire, and where available, for Phase 2 based on the responses
to the Phase 2 interview.

There are 11 exposure related variables for each of the 50 pesticides
from the enrollment questionnaire.  These exposure variables include an
indicator for use at enrollment, and indicator for use during the Phase
2 reference year (RY), and values for lifetime years of use, lifetime
days of use, and lifetime intensity days of use, without lagging, and
with a 5 year and a 15 year lag. These variable names for ATRAZINE are
as follows:

  ---------------------- ------------------------------------------------
  **NAME**               **LABEL**

  A_HERBICIDE_CD1        Ever personally mixed or applied ATRAZINE at
                         Enrollment

  A2_HERBICIDE_RY_A_1    Indicator for personally applied ATRAZINE in
                         Phase 2

  YRS_HRB1               ATRAZINE years used at start of each time period

  YRS_LAG5_HRB1          ATRAZINE yrs used at start of each time period,
                         5-yr lag

  YRS_LAG15_HRB1         ATRAZINE yrs used at start of each time period,
                         15-yr lag

  LTDAYS_HRB1            ATRAZINE lifetime days at start of each time
                         period

  LTDAYS_LAG5_HRB1       ATRAZINE lifetime days at start of each time
                         period, 5-yr lag

  LTDAYS_LAG15_HRB1      ATRAZINE lifetime days at start of each time
                         period, 15-yr lag

  IWDAYS_HRB1            ATRAZINE intensity-weighted days at start of
                         each time period

  IWDAYS_LAG5_HRB1       ATRAZINE iw-days at start of each time period,
                         5-yr lag

  IWDAYS_LAG15_HRB1      ATRAZINE iw-days at start of each time period,
                         15-yr lag
  ---------------------- ------------------------------------------------

2.0 Data Structure and Time Periods

The analytical files have an enhanced data structure that includes time
dependent exposure variables with multiple records per subject. The
structure consists of two-year time periods from enrollment through the
cutoff date for person-time for each study enrollee. The two-year
periods begin with 1993-1994 (period #1) and continue through 2005-2006
(period #7) which includes the most recent year for which full follow-up
data is available for the study (currently 2005). The first period for
each subject always includes the year of enrollment and is thus a
partial period, in that the person-years (P_YRS) of follow-up starts at
the date of enrollment, and therefore has a value less than two. Since
the earliest enrollment dates are in December 1993 and latest enrollment
dates are towards the end of 1997, the period number on the first record
can range from 1 to 3. All intermediate records will have P_YRS=2 since
they cover the subsequent full two-year periods. The final record for
most subjects will also cover a full period of either one or two years
depending on the current year of full follow-up for the study. There are
three reasons why person-time is cut at some point other than December
31^st^ of the current year of full follow-up: 1) a subject has a cancer
diagnosis on record with a diagnosis date after their date of
enrollment; 2) the subject is deceased, in which case person-time ended
on their date of death; or 3) the subject moved out of state so
follow-up efforts would not find future developments, such as cancer
diagnoses, in which case their person-time ends at the given date they
left the state or some assigned date when no movement date is available.
There were 292 subjects who lived out of state at enrollment, and thus
were not eligible for cancer follow-up. These subjects have a single
record with a missing value for both follow-up period number and total
person years of follow-up.

Number of Subjects in Cancer Analytic File by Number of Follow-Up
Periods

  ----------------------- ----------------------- -----------------------
  Max Period              Freq                    \%

  1                       128                     0.22

  2                       780                     1.36

  3                       1,216                   2.12

  4                       1,580                   2.76

  5                       1,537                   2.68

  6                       1,511                   2.64

  7                       50,266                  87.71

  . missing               292                     0.51

  Total                   57,310                  
  ----------------------- ----------------------- -----------------------

When using the data file for epidemiological analysis, an individual
(and his/her multiple records) no longer constitutes the unit of
analysis.   Each \"record\" represents a distinct virtual individual
(with \<= 2-years of follow-up) and constitutes the analytic unit of
person-time observation.

Table 1 provides an example of how the days of use for a specific
pesticide (e.g. Atrazine) from the Phase 1 and Phase 2 are merged using
the new data structure. In this example, the applicator enrolled in
January 1994, approximately halfway through Period 1: 1993-1994. He
reported 2 to 5 years of use for 10 to 19 days per year at enrollment.
Multiplication of the mid-points of the two ranges provides an estimate
of 3.5 x 14.5 = 50.8 lifetime days of use at enrollment. The version 2
algorithm intensity score calculated for use of herbicides based on the
enrollment questionnaire for this subject is 25, which multiplied by the
lifetime days of use, results in 1269 intensity-weighted days (i.e.
IW-Days) at enrollment. The Phase 2 interview for this subject was
completed in 2000, with a reference year of 1999, a span of 6 years
since the enrollment. He reported use for a total of 4 days during the
Phase 2 reference year, which in this case is consistent with the usage
rate of 2 to 5 days per year in Phase 1. By assuming use during the
reference year is representative of use since enrollment, he accumulates
a total of 24 additional lifetime days between enrollment and the Phase
2 reference year. The version 2 algorithm score for use of Atrazine
calculated based on the Phase 2 questionnaire is 44, somewhat higher
than the Phase 1 score of 25. For Phase 1, algorithm scores were
calculated for general types of pesticides (i.e. herbicides), while in
Phase 2, algorithm scores were calculated based on the application
methods used for specific pesticides (i.e. Atrazine). Due to the
structure of the Phase II CATI, application method was not collected for
approximately 9% of the applications for which we have information on
days of use.   For these applicators, we have a value for lifetime days,
but not lifetime intensity-days, and therefore, these applicators would
potentially be excluded from analyses based on lifetime intensity
weighted days.  Using the extensive information collected on
applications for which the application method was provided, the missing
application methods could be inferred. Thus, when the application method
for specific pesticides applied in Phase 2 was not reported, the
application method was inferred based on the type of pesticide, similar
to the approach used in Phase 1. The days of use during Phase 2
multiplied by the intensity score results in an additional 1056
intensity-weight days of use. These additional days of use and intensity
days between enrollment and the Phase 2 reference year are added in two
year time periods, resulting in overall 32% increase in the lifetime
days and 45% increase in intensity-weighted days. Since no further
information after the Phase 2 interview is available, the exposure days
do not change after the period containing the Phase 2 reference year.
Algo

3.0 Lagged Lifetime Days

The analytical file also includes variables for lifetime days and
lifetime intensity days with 5 and 15 year lags. These lagged exposure
variables represent the estimated lifetime usage accrued as of 5 years
and 15 years prior to the start of each time period. The lagged values
were calculated based on a "Usage Array" in which patterns of use during
the fifteen year period prior to study enrollment are estimated based on
responses to the questions about the decade of first use, use last
season and the lifetime years of use on the enrollment and take-home
questionnaires. Table 3 displays the estimated years of use 5 years and
15 years prior to enrollment for each of the 72 possible combinations of
these three variables. Table 4 displays the usage arrays for applicators
whose decade of first use was the 1970's.

The initial record for each subject has values for lifetime days,
intensity-weighted lifetime days, and total years of exposure as of
enrollment. These values come directly from the enrollment
questionnaire. In addition, 5-year and 15-year lag variables are
included for each of these three measures. The procedure used to
calculate cumulative tallies for these exposure measures for both lagged
and non-lagged values increased according to the rate from the usage
array. Thus, each record has the lifetime days of use at the start of
the current two-year period, as well as the estimated usage accrued five
years and fifteen years ago.

Calendar years covered by Phase 1 use the value for average days per
year as reported in Phase 1 when incrementing the lifetime days. In
Phase 2 the applicators reported the actual number for the number of
days they used specific pesticides in the past/referent year. A value
greater than zero for days of use in the Phase 2 reference was required
for usage to be indicated. The Phase 2 days per year value is used as
the increment for lifetime days for those years starting with the year
after the Phase 1 reference year through the Phase 2 reference year.
Again, if pesticide use is indicated in the Phase 2 reference year, it
is considered to be used continuously through this period of calendar
time. The Phase 1 reference year is the interview year if the interview
took place in November or December, otherwise it is the prior year.
These two reference year variables drive the creation of the exposure
data in the analysis file.

4.0 Lifetime Days of Use for Specific Pesticides

Lifetime days of use for specific pesticides were calculated by summing
the lifetime days of use reported at enrollment with the days of use
between enrollment and the Phase 2 reference year. For applicators with
Phase 2 data, the values for lifetime exposure days and lifetime
exposure intensity days are updated through the Phase 2 reference year.
For applicators who did not participate in Phase 2, the values for
lifetime days of use at enrollment are retained for all subsequent
periods. Some of the applicators who did not participate in Phase 2 may
have continued to use the same pesticides reported at enrollment, in
which case their lifetime days for time periods after enrollment are
underestimated. For applicators who did not report any days of use for a
specific pesticide at enrollment, and who are missing the days of use
from Phase 2, the value for lifetime days use subsequent to enrollment
are presented as missing rather than 0. Table 2 summarizes how the Phase
1 and Phase 2 days were combined when one or the other was a missing
value.

Any values for lifetime days from either Phase 1 or Phase 2 are
retained.  If Phase 1 days are 0 and Phase 2 missing, then total days of
use at the start of the first follow up period are equal to the Phase 1
days, and total days of use for subsequent follow up periods are set to
missing.  The only 0's in the Total row, are the folks who reported 0
use in Phase 1 AND Phase 2.   Applicators with no Phase 2 data have
non-missing lifetime days only if they reported Phase 1 days.  These are
mostly the non-Phase 2 participants, but also includes some Phase 2
participants with missing days.

Analysts have three options:

1)  Use the data as is.  The "unexposed" reference group includes only
    applicators with 0 days in Phase 1 AND Phase 2, while the exposed
    group are subjects how reported days in Phase 1 OR Phase 2.  This is
    the default option which excludes the non-Phase 2 participants who
    reported zero days at enrollment, but not those who reported use at
    enrollment.

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1)  Change missing values to zero, which includes applicators with 0
    days in Phase 1 who did not participate in Phase 2.   This option
    assumes no use after enrollment for non-Phase 2 participants with 0
    use at enrollment (not a bad assumption in most cases), and includes
    the largest number of subjects.

2)  Exclude participants who did not participate in Phase 2 (i.e. the
    complete cohort). This option includes is the smallest number of
    subjects.

  

Phase 1 days are missing if the indicator for ever use in Phase 1 is
missing, or if either years of use or days per year of use in Phase 1 is
missing. The Phase 2 days are missing only for applicators who reported
use of an unknown pesticide. For any pesticide not mentioned in the
Phase 2 interview, or for any pesticide mentioned but having zero days
of personal use, the usage variable is first set to 0 (no), indicating
no use of that pesticide subsequent to enrollment. However, if the
applicator reported use of an unknown pesticide in one of the four
classes (herbicide, insecticide, fungicide, fumigant) of pesticides
without knowing the specific brand name or active ingredient, the Phase
2 days of use for all other pesticides in that class were set to
missing.

Thus for situations 1 and 6 in Table 2, the applicator did report use of
the pesticide, but the lifetime days are potentially underestimated. For
situations 2 and 9, the applicator did not report use, but the values
for days of use are missing for either Phase 1 or Phase 2. These
applicators can either be excluded, or these subjects can be included by
assuming zero days of lifetime use. These subjects can be identified
based on the combination of the Phase 1 and Phase 2 personal usage
variables.

There are times in the history of exposure for applicators where
exposure days are known to a point and then unknown afterwards. For
example, this occurs for applicators that did not have a Phase 2
interview. If they indicated use of a pesticide at enrollment and the
Phase 1 referent year is 1995 and their person-time runs through the
2005 cutoff, then we have ten years of calendar time that is not covered
by the data at hand. Or, it can happen for the time after the Phase 2
referent year through the cutoff date. In this case, the known exposure
numbers are carried forward for the periods not covered by the data.
Below is an example of this situation for an applicator that indicated
chlorpyrifos use in Phase 1 with no Phase 2 interview.

YRS\_ YRS\_

LAG5\_ LAG15\_

PARTID PH2 YEAR_IN YEAR_OUT P1REF_YR P2REF_YR YRS_INS8 INS8 INS8

100021 0 1994.03 1994.99 1993 . 8 4 0

100021 0 1995.00 1996.99 1993 . 8 5 0

100021 0 1997.00 1998.99 1993 . 8 7 0

100021 0 1999.00 2000.99 1993 . 8 8 0

100021 0 2001.00 2002.99 1993 . 8 8 1

100021 0 2003.00 2004.99 1993 . 8 8 3

In the above example, there are 8 years of chlorpyrifos use assigned
which are shown in YRS_INS8 on each record for this applicator. No data
are available for use after 1993, but the 8 years of use are retained.
The 5-year lag variable starts at four years and increases until the
total of eight years is reached and then remains at that figure for the
following periods even though exposure through these periods is unknown.

However, when no exposure is indicated in Phase 1 and use during Phase 2
is unknown, then the exposure measures become missing values at the
appropriate points as in this example.

YRS\_ YRS\_

LAG5\_ LAG15\_

PARTID PH2 YEAR_IN YEAR_OUT P1REF_YR P2REF_YR YRS_INS8 INS8 INS8

100003 0 1994.03 1994.99 1993 . 0 0 0

100003 0 1995.00 1996.99 1993 . . 0 0

100003 0 1997.00 1998.99 1993 . . 0 0

100003 0 1999.00 2000.99 1993 . . 0 0

100003 0 2001.00 2002.99 1993 . . . 0

100003 0 2003.00 2004.99 1993 . . . 0

5.0 Cancer Variables

Cancer variables for roughly 30 types of cancer and total person-years
variable (PERSON_YRS) are added to the selected questionnaire variables.
The cancer flags represent the first diagnosis after enrollment. All
cancer flags have zero values on every record except the final record.
Subjects having a cancer diagnosis post-enrollment will have the cancer
flag for any cancer (CANCER_POST) along with one of the flags for a
specific cancer set to 1 on the last record. The date of diagnosis is
provided both as a SAS date (POSTDX1_DT) and in three variables
(POSTDX1_MM, POSTDX1_DD, POSTDX1_YR) for diagnosis month, day, and year.
There also is a variable (CANCER_PRE) indicating whether or not subjects
have a cancer on record with diagnosis date prior to their enrollment
date. **If one wants an analysis of true primary cancers, then subjects
with cancer pre-enrollment should be dealt with in whatever manner is
deemed appropriate**.

A list of the administrative, demographic and cancer outcome variables
are presented in Attachments 1 and 2.

TABLE 1: Example from Phase 1 and Phase 2 Updated File

  ----------------------------------- --------------------- ------------ ------------
  Participant ID                                            xxxxxx       

  Date of Enrollment                                        11-Jan-94    

  Age at Enrollment                                         32           

  Years of Use at Enrollment                                2 to 5       

  Days per Year at Enrollment                               10 to 19     

  Lifetime Days at Enrollment                               50.8         

  Ver 2 Intensity Score Phase 1                             25           

  IW Days at Enrollment                                     1269         

                                                                         

  Year of Phase 2 Interview                                 2000         

  Reference Year Phase 2                                    1999         

  Years since Enrollment                                    6            

  Days of Use during P2 RY                                  4            

  Days of Use since Enrollment                              24           

  Ver 2 Intensity Score Phase 2                             44           

  IW Days Phase 2                                           1056         

                                                                         

  Lifetime Days                                             74.8         

  Lifetime IW Days                                          2325         

  Date of Last Follow Up                                    12/31/2005   

                                                                         

                                      [Exposure at Start of              
                                      Time                               
                                      Period]{.underline}                

                                                                         Version 2

  Time Period                         PY                    Days         IW-Days

  1\) 1993-1994                       0.97                  50.8         1269

  2\) 1995-1996                       2.0                   54.8         1445

  3\) 1997-1998                       2.0                   62.8         1797

  4\) 1999-2000                       2.0                   70.8         2149

  5\) 2001-2002                       2.0                   74.8         2325

  6\) 2003-2004                       2.0                   74.8         2325

  7\) 2005-2006                       1.0                   74.8         2325

  Total Person Years                  11.97                              

  increase =                                                32%          45%
  ----------------------------------- --------------------- ------------ ------------

![](media/image1.wmf){width="4.753472222222222in"
height="3.245138888888889in"}

Table 2: Lifetime days of use from Phase 1 and Phase 2 interviews.

  ------- ---------------------- ---------------------- -------------------
          Phase 1 Days           Phase 2 Days           Lifetime Days

  1       \#                     missing                \# (1)

  2       0                      missing                missing

  3       missing                missing                missing

  4       \#                     \#                     \# + \#

  5       0                      \#                     \#

  6       missing                \#                     \# (1)

  7       \#                     0                      \#

  8       0                      0                      0

  9       missing                0                      missing
  ------- ---------------------- ---------------------- -------------------

\# = non-zero, non-missing number

0 = reported no use

missing = reported use but missing years of use, days per year, or both

\(1\) = censored or partial values

Table 3: Values for Years of Use at Enrollment with 5 and 15 Years Lags
by Decade of First Use, Use Last Season and Total Years of Use Reported
on Enrollment Questionnaire

  ----------- ----------- ----------- ----------- ----------- -----------
                          5-Year Lag              15-Year Lag 

                          used last               used last   
                          season:                 season:     

                          no          yes         no          yes

  decade of   years       years       years       years       years

  first use   of use      of use      of use      of use      of use

  \<1960      1           1           0           1           0

              3.5         3.5         2.5         3.5         1.5

              8           8           7           8           5

              15.5        15.5        13.5        12.5        9.5

              25.5        25.5        22.5        15.5        16.5

              35          31          30          21          20

  1960\'s     1           1           0           1           0

              3.5         3.5         2.5         0.5         0.5

              8           8           6           8           4

              15.5        15.5        12.5        14.5        7.5

              25.5        24.5        21.5        14.5        13.5

              35          31          30          21          20

  1970\'s     1           1           0           1           0

              3.5         3.5         2.5         3.5         0.5

              8           8           6           5           2

              15.5        15.5        11.5        5.5         3.5

              25.5        21.5        20.5        11.5        10.5

              35          31          30          21          20

  1980\'s     1           1           0           0           0

              3.5         3.5         1.5         0           0

              8           4           3.0         0           0

              15.5        11.5        10.5        1.5         0.5

              25.5        21.5        20.5        11.5        10.5

              35          31          30          21          20

  1990\'s     1           0           0           0           0

              3.5         0           0           0           0

              8           4           3           0           0

              15.5        11.5        10.5        1.5         0.5

              25.5        21.5        20.5        11.5        10.5

              35          31          30          21          20

  Missing     1           0           0           0           0

              3.5         0           0           0           0

              8           4           3           0           0

              15.5        11.5        10.5        1.5         0.5

              25.5        21.5        20.5        11.5        10.5

              35          31          30          21          20
  ----------- ----------- ----------- ----------- ----------- -----------

Table 4: Usage arrays for 15 years prior to enrollment for decade of
first use equals 1970

  ---------------- ------ -------- -------- -------- -------- -------- --------
  decade of first         1970s    1970s    1970s    1970s    1970s    1970s
  use:                                                                 

  years of use:           1        3.5      8        15.5     25.5     35

  used last               yes      yes      yes      yes      yes      yes
  season:                                                              

  usage rate:             1 / 15   3 / 15   6 / 15   12 / 15  15 / 15  15 / 15

  Years prior      -1     1        1        1        1        1        1

  to enrollment    -2     0        0        1        1        1        1

                   -3     0        0        0        1        1        1

                   -4     0        0        0        1        1        1

                   -5     0        0        0        0        1        1

                   -6     0        1        1        1        1        1

                   -7     0        0        1        1        1        1

                   -8     0        0        0        1        1        1

                   -9     0        0        0        1        1        1

                   -10    0        0        0        0        1        1

                   -11    0        1        1        1        1        1

                   -12    0        0        1        1        1        1

                   -13    0        0        0        1        1        1

                   -14    0        0        0        1        1        1

                   -15    0        0        0        0        1        1

  used last               no       no       no       no       no       no
  season:                                                              

  usage rate:             0 / 15   0 / 15   3 / 15   10 / 15  14 / 15  14 / 15

  Years prior      -1     0        0        0        0        0        0

  to enrollment    -2     0        0        0        0        1        1

                   -3     0        0        0        0        1        1

                   -4     0        0        0        0        1        1

                   -5     0        0        0        0        1        1

                   -6     0        0        0        1        1        1

                   -7     0        0        0        1        1        1

                   -8     0        0        0        1        1        1

                   -9     0        0        0        1        1        1

                   -10    0        0        0        1        1        1

                   -11    0        0        0        1        1        1

                   -12    0        0        0        1        1        1

                   -13    0        0        1        1        1        1

                   -14    0        0        1        1        1        1

                   -15    0        0        1        1        1        1
  ---------------- ------ -------- -------- -------- -------- -------- --------

usage rate = estimated years of use during 15 year period prior to
enrollment

ATTACHMENT 1: Administrative and Demographic Variables

  ------------- --------------------------------------------- -------------
  **NAME**      **LABEL**                                     **DOMAIN**

  PARTID        Participant Identifier                        Admin

  SITE          Site                                          Admin

  ATYEAR        E1: Year in which enrollment completed        Admin

  ATDAY         E2: Day in which enrollment completed         Admin

  ATMONTH       E2: Month in which enrollment completed       Admin

  P1REF_YR      Reference year for Phase 1, assigned          Admin
                similarly to that of Phase 2                  

  PH2           Phase 2 interview data, 0=No, 1=Yes           Admin

  P2REF_YR      Reference year calculated from variables      Admin
                A2ACFARM, A2STFARM, A2LAFARM AND              
                A2_SASDATE_STARTDA                            

  AGE_IN        Age at beginning of each time period          Admin

  AGE_OUT       Age at end of each time period                Admin

  PERIOD_NUM    Calendar period, 1=1993-1994 \... 7=2005-2006 Admin

  P_YRS         Person-years of individual time periods       Admin

  PERSON_YRS    Total p-yrs (12/31/2004 cutoff date)          Admin

  YEAR_IN       Value for year at beginning of each time      Admin
                period                                        

  YEAR_OUT      Value for year at end of each time period     Admin

  DOB           Birth date - day                              Demographic

  MOB           Birth date - month                            Demographic

  YOB           Birth date - year                             Demographic

  AALCFREQ      E21: Alcohol frequency per year               Demographic

  AALCNUM       E22: Drinks per day last year                 Demographic

  ASMOK100      E23: 100 or more cigarettes in lifetime       Demographic

  ASMOKNOW      E24: Smoke now                                Demographic

  ASMOKPDY      E25: Cigarettes per day                       Demographic

  ASMOKYRS      E26: Years smoked                             Demographic

  ASCHOOL       E5: Highest level of schooling                Demographic

  BMI_P1        Estimated body mass index at enrollment       Demographic

  AOCCURYR      F27,C19: Decade of highest exposure           Demographic
  ------------- --------------------------------------------- -------------

ATTACHMENT 2: Cancer Outcome Variables

  ------------------------------- ----------------------------- -----------
  CANCER_PRE                      1+ cancer DX pre-enr          Outcome

  BLADDER_FIRST_POST_DX           Bladder, first Dx post-enr,   Outcome
                                  match for PY\'s               

  BLOOD_FIRST_POST_DX             Blood, first Dx post-enr,     Outcome
                                  match for PY\'s               

  BRAIN_FIRST_POST_DX             Brain & ONS, first Dx         Outcome
                                  post-enr, match for PY\'s     

  COLON_FIRST_POST_DX             Colon, first Dx post-enr,     Outcome
                                  match for PY\'s               

  ESOPHAGUS_FIRST_POST_DX         Esophagus, first Dx post-enr, Outcome
                                  match for PY\'s               

  FEMALE_BREAST_FIRST_POST_DX     Female breast, first Dx       Outcome
                                  post-enr, match for PY\'s     

  GALL_BILIARY_FIRST_POST_DX      Gallbladder & other biliary,  Outcome
                                  first Dx post-enr, match for  
                                  PY\'s                         

  HODGKINS_FIRST_POST_DX          Hodgkins, first Dx post-enr,  Outcome
                                  match for PY\'s               

  KIDNEY_FIRST_POST_DX            Kidney, first Dx post-enr,    Outcome
                                  match for PY\'s               

  LARYNX_FIRST_POST_DX            Larynx, first Dx post-enr,    Outcome
                                  match for PY\'s               

  LEUKEMIA_FIRST_POST_DX          Leukemia, first Dx post-enr,  Outcome
                                  match for PY\'s               

  LIP_FIRST_POST_DX               Lip, first Dx post-enr, match Outcome
                                  for PY\'s                     

  LIVER_FIRST_POST_DX             Liver, first Dx post-enr,     Outcome
                                  match for PY\'s               

  LUNG_FIRST_POST_DX              Lung, first Dx post-enr,      Outcome
                                  match for PY\'s               

  MELANOMA_SKIN_FIRST_POST_DX     Melanoma skin, first Dx       Outcome
                                  post-enr, match for PY\'s     

  MMYELOMA_FIRST_POST_DX          Multiple Myeloma, first Dx    Outcome
                                  post-enr, match for PY\'s     

  NHL_FIRST_POST_DX               NHL, first Dx post-enr, match Outcome
                                  for PY\'s                     

  ORAL_CAVITY_FIRST_POST_DX       Oral cavity, first Dx         Outcome
                                  post-enr, match for PY\'s     

  OVARY_FIRST_POST_DX             Ovary, first Dx post-enr,     Outcome
                                  match for PY\'s               

  PANCREAS_FIRST_POST_DX          Pancreas, first Dx post-enr,  Outcome
                                  match for PY\'s               

  PHARYNX_FIRST_POST_DX           Pharynx, first Dx post-enr,   Outcome
                                  match for PY\'s               

  PROSTATE_FIRST_POST_DX          Prostate, first Dx post-enr,  Outcome
                                  match for PY\'s               

  RECTUM_FIRST_POST_DX            Rectum, first Dx post-enr,    Outcome
                                  match for PY\'s               

  SMALL_INTESTINE_FIRST_POST_DX   Small intestine, first Dx     Outcome
                                  post-enr, match for PY\'s     

  SOFT_TISSUE_FIRST_POST_DX       Soft tissue, first Dx         Outcome
                                  post-enr, match for PY\'s     

  STOMACH_FIRST_POST_DX           Stomach, first Dx post-enr,   Outcome
                                  match for PY\'s               

  TESTIS_FIRST_POST_DX            Testis, first Dx post-enr,    Outcome
                                  match for PY\'s               

  THYROID_FIRST_POST_DX           Thyroid, first Dx post-enr,   Outcome
                                  match for PY\'s               

  TONGUE_FIRST_POST_DX            Tongue, first Dx post-enr,    Outcome
                                  match for PY\'s               

  POSTDX1_DD                      Dx day, 1st after enrollment  Outcome

  POSTDX1_DT                      Date Dx of 1st cancer after   Outcome
                                  enrollment                    

  POSTDX1_GRADE                   Dx grade, 1st Dx after        Outcome
                                  enrollment                    

  POSTDX1_MM                      Dx month, 1st after           Outcome
                                  enrollment                    

  POSTDX1_MORPH                   Morphology code, 1st Dx after Outcome
                                  enrollment                    

  POSTDX1_SITE                    ICD-O site code, 1st Dx after Outcome
                                  enrollment                    

  POSTDX1_STAGE                   Dx stage, 1st Dx after        Outcome
                                  enrollment                    

  POSTDX1_YR                      Dx year, 1st after enrollment Outcome

  ARDIS1                          E29a: Blood relative ever had Outcome
                                  Lung cancer                   

  ARDIS10                         E29j: Blood relative ever had Outcome
                                  Lymphoma                      

  ARDIS11                         E29k: Blood relative ever had Outcome
                                  other Cancer                  

  ARDIS12                         E29l: Blood relative ever had Outcome
                                  Kidney Failure                

  ARDIS13                         E29m: Blood relative ever had Outcome
                                  sugar Diabetes                

  ARDIS14                         E29n: Blood relative ever had Outcome
                                  heart attack before 50        

  ARDIS2                          E29b: Blood relative ever had Outcome
                                  Colon Cancer                  

  ARDIS3                          E29c: Blood relative ever had Outcome
                                  Breast Cancer                 

  ARDIS4                          E29d: Blood relative ever had Outcome
                                  Melanoma                      

  ARDIS5                          E29e: Blood relative ever had Outcome
                                  other Skin Cancer             

  ARDIS6                          E29f: Blood relative ever had Outcome
                                  Stomach Cancer                

  ARDIS7                          E29g: Blood relative ever had Outcome
                                  Leukemia                      

  ARDIS8                          E29h: Blood relative ever had Outcome
                                  Brain Cancer                  

  ARDIS9                          E29i: Blood relative ever had Outcome
                                  Prostate Cancer               
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