**[STATEMENT OF WORK]{.underline}**

**Helgi Valdimarsson**

**BACKGROUND INFORMATION\
**\
Dr. Helgi Valdimarsson is presently a Professor of Immunology at the
Department of Immunology, Institute for Medical Laboratory Sciences,
Lanspitali, University Hospital, in Reykjavik, Iceland.

The Laboratory of Host Defenses, Division of Intramural Research,
National Institute of Allergy and Infectious Diseases is an organization
that recognizes the need to plan, implement, and maintain an active
program of research to promote the mission of the NIAID. The mission of
the Mucosal Immunity Section in particular is to conduct a broad
spectrum of studies on the immune system of mucosal surfaces. Current
studies focus on experimental models of ulcerative colitis and the
mechanisms underlying ulcerative colitis. These studies involve a wide
range of molecular biology and biochemical techniques. The Laboratory is
well equipped with cell purification, culturing, imaging,and other
technologies necessary to carry out such experiments. The members of the
Laboratory are interactive and hold weekly seminaras and journal clubs
to facilitate the design and analysis of experiments.\
.\
**PURPOSES AND OBJECTIVES OF THE ACQUISITION\
**\
The purpose of this procurement is to allow Dr. Valdimarsson to evaluate
the effects that the thymus stromal lymphopoietin (TSLP) may have on
human alpha24 and NK T cells. Studies he has begun in his laboratory in
Iceland will be central to the collaboration of the laboratory headed by
Dr. Warren Strober. The period of performance is from September 23, 2006
through December 20, 2006.

**CONTRACTOR REQUIREMENTS\
**\
In particular, Dr. Valdimarsson will be examining thymuses extracted
from mice specially bred for the purpose here at the NIH. Techniques
developed in the Mucosal Immunity Section will be adapted and improved.
During this work, Dr. Valdimarsson will maintain complete records so as
to provide a basis for subsequent publication in peer-reviewed
journals.\
\
**CONTRACTOR SUPPLIED MATERIALS\
**\
The contractor shall provide her own laptop, writing instruments, and
notebooks.\
\
**GOVERNMENT RESPONSIBILITIES**

The Mucosal Immunity Section, LHD, DIR, NIAID stipulates that we will
provide\
Dr. Valdimarsson with acess to the laboratory equipment and computers
that are required to complete Dr. Valdimarsson's experiments and to
write up a manuscript. This includes access to telephones, fax machines,
printers, copiers, and office supplies. Work products (experimental
results) and manuscripts will be submitted to Dr. Strober of the MIS,
LHD, DIR, NIAID for final review and approval. Work products will be
monitored daily and weekly by the Head of the Mucosal Immunity Section,
who is Dr. Warren Strober.

**REPORTING REQUIREMENTS AND DELIVERABLES**

Work products will be monitored daily and weekly by the Head of the
Mucosal Immunity Section, who is Dr. Warren Strober.\
\
**PROGRAM MANAGEMENT AND CONTROL REQUIREMENTS\
**\
Dr. Warren Strober will assure that tasks are completed under the terms
of this contract. The final work product -- that is, the manuscript --
will be submitted to the Head of the Mucosal Immunity Section for
approval.\
\
**INSPECTION AND ACCEPTANCE**

a\) Work products described above will be reviewed and approved on-site
by Dr. Warren Strober, the laboratory supervisor, in the Mucosal
Immunity Section, LHD, DIR, NIAID.\
\
b) All work will be completed in accordance with professional
standards.\
\
**ATTACHMENTS\
**\
None\
\
**JUSTIFICATION OF NEED\
\
**The MIS,LHD,DIR,NIAID requires specific knowledge and experience in
the evaluation of the effects that the thymus stromal lymphopoietin may
have on human alpha24 and NKT cells. In particular, cell purification,
culturing, and analysis is required. A thorough familiarity with these
techniques is required to successfully complete the experiments needed
to determine the functional relevance of these proteases.\
\
**SOLE SOURCE PROCUREMENT**\
\
Dr. Valdimarsson has several years of experience as a scientist in a
leading Icelandic laboratory that focuses on autoimmune disorders. He is
familiar with the methods of cell culturing and cell purification. Dr.
Valdimarsson is well-qualified to carry out the experimental work that
is required here to evaluate the effects that the thymus stromal
lymphopoietin may have on human alpha24 and NKT cells.

**INDEPENDENT GOVERNMENT COST ESTIMATE\
**\
Cost breakdown

  ------------------------- ---------------------------- -----------------------------------------
  9/23/06                   \$2,048                      (Subsistence for September, 8 days)

  10/1/06                   \$7,130                      (Subsistence for October, 31 days)

  11/1/06                   \$6,900                      (Subsistence for November, 30 days)

  12/1/06                   \$4,600                      (Subsistence for December, 20 days)

  **[TOTAL]{.underline}**   **[\$20,422]{.underline}**   
  ------------------------- ---------------------------- -----------------------------------------

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