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**UNITED STATES ENVIRONMENTAL PROTECTION AGENCY**

WASHINGTON, D.C. 20460

+-----------------------------------------------------------------------+
| OFFICE OF                                                             |
|                                                                       |
| PREVENTION, PESTICIDES,                                               |
|                                                                       |
| AND TOXIC SUBSTANCES                                                  |
+-----------------------------------------------------------------------+

**[MEMORANDUM]{.underline}**

**Date**: August 1, 2006

**Subject:** **Triadimefon & Triadimenol:** Aggregate Acute, Chronic,
and Short-Term Risk Assessments Reflecting July, 2006 Risk Mitigation in
Response to the Phase 4 Triadimefon RED.

DP Barcode: D331455 PC Codes: 109901 and 127201

40 CFR §: 180.410 Chemical Class: Azole

**From:** Yvonne Barnes, Chemist

Reregistration Branch II

and

Sheila Piper, Chemist

Chemistry and Exposure Branch

Health Effects Division (7509P)

**Through:** William J. Hazel, Branch Chief

Reregistration Branch II

Health Effects Division (7509P)

**To:** Richard Griffin, Risk Assessor

Reregistration Branch II

Health Effects Division (7509P)

and

John Pates, Chemical Review Manager

Reregistration Branch I

Special Review and Reregistration Division (7508P)

**Executive Summary**

Revised acute and chronic aggregate dietary (triadimefon and
triadimenol) food and water exposure and risk assessments were conducted
using the Dietary Exposure Evaluation Model software with the Food
Commodity Intake Database (DEEM-FCID, Version 2.03), which uses food
consumption data from the U.S. Department of Agriculture's Continuing
Surveys of Food Intakes by Individuals (CSFII) from 1994-1996 and 1998.
The analyses were performed in response to the registrant, Bayer
CropScience's agreement to voluntarily cancel all food uses, except for
pre-plant and post-harvest use on pineapples for triadimefon. Food uses
to be cancelled include apples, pears, grapes, and raspberries
(commercial or residential). EPA will issue a 6f notice proposing to
cancel these uses; Bayer will waive the 6 month comment period to 30
days.

[Acute Aggregate Dietary Exposure Characterization of Input
Data]{.underline}

This risk assessment represents aggregation of triadimefon and
triadimenol residues resulting from the metabolism of triadimefon as
well as the use of triadimenol as an active ingredient. This dietary
exposure and risk assessment for triadimefon and triadimenol includes
the following: field trial data for pineapples and bananas, seed
treatment tolerances for barley, corn, oat, rye, cottonseed, and wheat
and the new drinking water mitigation proposed by Bayer: two
applications per season at 2.7 lb ai/A and 14-day interval made to the
entire golf course. The assessment includes the time series data from
the PRZM EXAMS model of the drinking water scenario. Although exposure
to residue in/on banana and pineapple food-forms and drinking water were
estimated probabilistically, 100%CT was used for all foods and
tolerances were used (grain crops and cottonseed products). As a result,
standard policy is to evaluate at the 95^th^ percentile since tolerance
level residues and 100% crop treated was used.

[Acute Aggregate Dietary Exposure Results]{.underline}

***Acute Aggregate Dietary Food Only***

*Triadimefon Food (pineapples only) + Triadimenol Food (bananas and seed
treatments)*

The acute aggregate dietary exposure estimates from food only are below
HED's level of concern (\<100% aPAD) at the 95^[th]{.underline}^
percentile of exposure. The acute aggregate dietary risk at the
95^[th]{.underline}^ percentile of exposure from food only is 15% of the
aPAD for the U.S. population and 33% of the aPAD for children 1-2 yrs,
the most highly exposed population subgroup.

***Acute Aggregate Dietary Water Only***

*DW from 2 apps at 2.7 lb ai/A to Entire Course*

The acute aggregate dietary exposure estimates from drinking water only
using the Florida turf (two applications) for drinking water are below
HED's level of concern (\<100% aPAD) at the 95^[th]{.underline}^
percentile of exposure. At the 95^[th]{.underline}^ percentile of
exposure, risks were estimated to be 24% and 85% of the aPAD for the
U.S. population and all infants (\<1 yr), respectively.

***Acute Aggregate Dietary (food + water)***

*Triadimefon Food (pineapples only) + Triadimenol Food (bananas and seed
treatments) + DW from 2 apps at 2.7 lb ai/A to Entire Course*

The acute aggregate dietary exposure estimates from food and drinking
water using Florida turf with two applications for drinking water are
below HED's level of concern (\<100% aPAD) at the 95^[th]{.underline}^
percentile of exposure. At the 95^[th]{.underline}^ percentile of
exposure risks were estimated to be 33% and 94% of the aPAD for the U.S.
population and all infants (\<1 yr), respectively.

[Chronic Aggregate Dietary Exposure Results]{.underline}

***Chronic Dietary Food Only***

*Triadimefon Food (pineapples only) + Triadimenol Food (bananas and seed
treatments)*

The chronic aggregate dietary exposure estimates from food only are
below HED's level of concern (\<100% cPAD) for the U.S. population and
all population subgroups. The chronic aggregate dietary risk from food
only for the U.S. population is 6% of the cPAD and 15% of the cPAD for
children 1-2 yrs, the most highly exposed population subgroup.

***Chronic Aggregate Water Only***

*DW from 2 apps at 2.7 lb ai/A to Entire Course*

The chronic aggregate dietary exposure estimates from drinking water
only using the Florida turf with two applications, are below HED's level
of concern (\<100% cPAD) for the U.S. population and all population
subgroups. The aggregate dietary risk from drinking water for the U.S.
population is 12% of the cPAD and 40% of the cPAD for all infants (\<1
yr), the most highly exposed population subgroup.

***Chronic Aggregate (food + water)***

*Chronic Aggregate Dietary/Triadimefon Food (pineapples only) +
Triadimenol Food (bananas and seed treatments) + DW from 2 apps at 2.7
lb ai/A to Entire Course*

The chronic aggregate dietary exposure estimates from food and drinking
water using Florida turf, two applications are below HED's level of
concern (\<100% cPAD) for the U.S. population and all population
subgroups. The aggregate dietary risk from food and drinking water for
the U.S. population is 18% of the cPAD and 47% of the cPAD for all
infants (\<1 yr), the most highly exposed population subgroup.

[Short-term Aggregate]{.underline}

***Short-term Aggregate (adults)***

*Application to ornamentals (azaleas) + chronic dietary + chronic water*

The short-term aggregate risk reflecting residential handler scenarios:
Application to ornamentals (azaleas = worst case residential handler
(MOE of 1100 for dermal + inhalation). The resulting short-term
aggregate has a MOE of 920 which exceeds HED level of concern. Another
scenario

residential handler (mixer, loader, applicator) for low-pressure
hand-wand application of a WP to green house ornamental has a MOE of
1700 (dermal + inhalation).  The resulting short --term aggregate MOE is
1300.

***Short-term Aggregate (toddlers)***

*Post-application exposure to sod farm turf + chronic dietary + chronic
water*

Short-term aggregate for toddlers due to post-application exposure to
treated sod (i.e. sod transplanted to a residential lawn). The MOE
(combined hand-to-mouth, dermal and inhalation) at a sod pre-harvest
interval of 15 days was 1100; the MOE was of concern (\<1000) at 14
days.  The chronic dietary (food + water) exposure for children 1-2
years is a MOE of 3100.  The resulting short-term aggregate MOE was 810.

On day 17, the combined MOE's for toddlers on sod treated at the 2.7 lb
a.i./A rate is 1700. When this rate is aggregated with the chronic
dietary (food and water) MOE of 3100 MOE, the resultant aggregate is
1100. The individual MOE's are as follows: a) Hand-To-Mouth = 2500; b)
Object-To-Mouth = 10,000; c) Soil = 31,000; Dermal = 11,000.

The short-term toddler aggregate on day 16 is 920.

**I. Introduction**

Dietary risk assessment incorporates both exposure and toxicity of a
given pesticide. For acute dietary, chronic dietary and aggregate
assessments, the risk is expressed as a percentage of a maximum
acceptable dose (i.e., the dose which the Health Effects Division has
concluded will result in no unreasonable adverse health effects). This
dose is referred to as the population adjusted dose (PAD). The PAD is
equivalent to the Reference Dose (RfD) divided by the FQPA Safety
Factor.

For acute and non-cancer chronic exposures, HED is concerned when
estimated dietary risk exceeds 100% of the PAD. References which discuss
the acute and chronic dietary risk assessments in more detail are
available on the EPA pesticides web site: "Available Information on
Assessing Exposure from Pesticides, A User's Guide," 06/21/2000, web
link: [http://www.epa.gov /fedrgstr/EPA‑PEST
/2000/July/Day‑12/6061.pdf]{.underline}; or see SOP 99.6 (08/20/1999).

The two most recent dietary risk assessments for triadimefon and
triadimenol were conducted by Y. Barnes and S. Piper (DP Barcode
D314778, Revised 06-July-2006) and S. Ary (DP Barcode D314778,
23-NOV-2005).

**II. Residue Information**

Tolerances are established for residues of triadimefon
\[1-(4-chlorophenoxy)-3, 3-dimethyl-1-(1H-1, 2,
4-triazol-1-yl)-2-butanone\] and its metabolites containing
chlorophenoxy and triazole moieties (expressed as the parent compound)
in/on various plant and animal commodities \[40 CFR §180.410\].

Triadimenol,
b-(4-chlorophenoxy)-a-(1,1-dimethylethyl)-1H-1,2,4-triazole-1-ethanol,
is a systemic fungicide registered for use in the United States as a
seed treatment for barley, corn, cotton, oats, rye, and wheat.
Additionally, an import tolerance on bananas has been established \[40
CFR §180.450\].

Bayer CropScience has agreed to voluntarily cancel all food uses, except
for pre-plant and post-harvest use on pineapples for triadimefon. Food
uses to be cancelled include apples, pears, grapes, and raspberries (in
both commercial and residential settings). EPA will issue a 6f notice
proposing to cancel these uses; Bayer will waive the 6 month comment
period to 30 days. Once the 30 day comment period closes, EPA will issue
a cancellation order, with an existing stocks provision of 1 year from
the effective date of cancellation. The associated tolerances will be
proposed for revocation.

The qualitative nature of triadimefon and triadimenol residues in plants
is understood based on adequate metabolism studies conducted with
grapes, cucumbers, tomatoes, and wheat. The Health Effects Division
(HED) Metabolism Assessment Review Committee (MARC) has determined that
the residues of concern in plants are triadimefon, triadimenol, KWG
1323, KWG 1342, and, in wheat only, KWG 1732 (S. Knizner, HED MARC
memorandum, 01/03/1994). Tolerances in poultry commodities are
unnecessary for triadimefon as there are no treated poultry feed items.
HED concluded that the then supported uses on apples, grapes, pears,
pineapples, and raspberries result in a 40 CFR §180.6(a)(3) situation
for ruminant commodities; i.e., there was and still is no reasonable
expectation of finite residues in ruminant commodities. Therefore,
tolerances in animal commodities are not required at the present time.

[Residue Data used for Acute and Chronic Dietary
Assessments]{.underline}

The anticipated residue estimates are based on field trial data
(pineapples and bananas) and seed treatment tolerances were used for
barley, corn, oat, rye and cottonseed and wheat. All triadimefon and
triadimenol acute and chronic residue estimates for crop commodities are
listed in Table 1. As stated above, the residues of concern in risk
assessment include three of triadimefon's metabolites: triadimenol, KWG
1323, and KWG 1342. Since MARC concluded that triadimefon, triadimenol,
KWG 1323, and KWG 1342 are residues of concern, residue data for these
metabolites were needed for conducting a dietary risk assessment.

[Residue Estimates for Individual Crops]{.underline}

[Pineapple:]{.underline} Pineapple field trial data submitted in MRID
42342307 were used. A total of ten trials were conducted and samples
were analyzed for triadimefon, triadimenol, KWG 1323, and KWG 1342. The
method LOQ was determined at 0.01 ppm. For values reported below the
LOQ, half the LOQ was used in calculating the total combined residues of
triadimefon, triadimenol, KWG 1323, and KWG 1342. All residue values
were corrected to 1x application rate. The estimated %CT for pineapples
of 100% was used for the acute and chronic dietary risk assessments.

[Bananas:]{.underline} Banana field trial data submitted in MRID
40615021 were used. A total of ten trials were conducted and samples
were analyzed for triadimefon, triadimenol, KWG 1323, and KWG 1342. The
method LOQ was determined at 0.01 ppm. For values reported below the
LOQ, half the LOQ was used in calculating the total combined residues of
triadimefon, triadimenol, KWG 1323, and KWG 1342. All residue values
were corrected to 1x application rate. The estimated %CT for bananas of
100% was used for the acute and chronic dietary risk assessments.

<table>
<colgroup>
<col style="width: 9%" />
<col style="width: 11%" />
<col style="width: 9%" />
<col style="width: 6%" />
<col style="width: 9%" />
<col style="width: 7%" />
<col style="width: 7%" />
<col style="width: 6%" />
<col style="width: 10%" />
<col style="width: 12%" />
<col style="width: 9%" />
</colgroup>
<thead>
<tr class="header">
<th colspan="11"><strong>Table 1: Triadimefon and Triadimenol Data and
Residue Estimates Used in Dietary Analyses</strong></th>
</tr>
<tr class="odd">
<th rowspan="2">RAC</th>
<th rowspan="2">Classification<sup>1</sup></th>
<th rowspan="2"><p>Data</p>
<p>Source</p></th>
<th rowspan="2">Years</th>
<th rowspan="2">No. of Samples</th>
<th rowspan="2"><p>No. of</p>
<p>Detects</p></th>
<th rowspan="2">% CT Avg.<sup>2</sup></th>
<th rowspan="2">% CT Max.<sup>2</sup></th>
<th rowspan="2"><p>Processing</p>
<p>Factors<sup>3</sup></p></th>
<th colspan="2">Anticipated Residue Estimates/Tolerance</th>
</tr>
<tr class="header">
<th>Acute (Tol., AR, RDF) ppm</th>
<th>Chronic (Tol., AR) ppm</th>
</tr>
</thead>
<tbody>
<tr class="odd">
<td>Pineapple</td>
<td>NB or PB</td>
<td>Field Trial MRID 42342307</td>
<td>1992</td>
<td>10</td>
<td>10</td>
<td>100</td>
<td>100</td>
<td>dried at 5.0</td>
<td><p>TOTALZ=0</p>
<p>TOTALLOD=0</p>
<p>LODRES=0.005</p>
<p>0.05, 0.08, 0.10, 0.10, 0.11, 0.08, 0.09, 0.06</p>
<p>0.07, 0.05</p></td>
<td>AR (0.079)</td>
</tr>
<tr class="even">
<td>Banana</td>
<td>NB or PB</td>
<td><p>Field Trial</p>
<p>MRID 40615201</p></td>
<td>1998</td>
<td>10</td>
<td>10</td>
<td>100</td>
<td>100</td>
<td>dried at 3.9</td>
<td><p>TOTALZ=0</p>
<p>TOTALNZ=10</p>
<p>0.04, 0.05, 0.02 0.05, 0.04, 0.015, 0.015, 0.025, 0.015,
0.03</p></td>
<td>AR (0.03)</td>
</tr>
<tr class="odd">
<td>Cottonseed</td>
<td>B</td>
<td>Tolerance</td>
<td>--</td>
<td>--</td>
<td>--</td>
<td>100</td>
<td>100</td>
<td>--</td>
<td>0.02</td>
<td>0.02</td>
</tr>
<tr class="even">
<td>Cereal, Corn &amp; Grains</td>
<td>NB, PB or B</td>
<td>Tolerance</td>
<td>--</td>
<td>--</td>
<td>--</td>
<td>100</td>
<td>100</td>
<td>bran at 2.1</td>
<td>0.05</td>
<td>0.05</td>
</tr>
<tr class="odd">
<td colspan="11"><p>1. Classification of blended (B), partially blended
(PB), not blended (NB).</p>
<p>2. 100%CT was used in the dietary assessment.</p>
<p>3. Processing study information may be found in the Chemistry Review
Document, guideline section 860.1520 Processed Food and Feed (S. Ary,
D314742, 9/16/2005).</p></td>
</tr>
</tbody>
</table>

[Processing Factors]{.underline}

Data from the processing studies were used in this assessment for
several commodities along with DEEM 7.81 default processing factors for
dried pineapple (5.0x), bananas (3.9x), barley and oat bran (2.1x). All
other processed commodities showed little or no concentration in the
available processing studies. For detailed considerations of processing
factors see "Triadimefon. Summary of Analytical Chemistry and Residue
Data for the Reregistration Eligibility Decision (RED) Document" under
guideline section 860.1520 (S. Ary, D314742, 09/16/2005).

III. **Drinking Water Data**

The drinking water values used in the dietary risk assessment were
provided by the Environmental Fate and Effects Division (EFED) in the
following email correspondence (J. Angier, 11-JUL-2006). Water residues
were incorporated in to DEEM-FCID food categories of "water, direct,
all sources" and "water, indirect, all sources."

The estimated drinking water concentrations (EDWCs) for triadimefon and
triadimenol were moderately refined and calculated using PRZM (Pesticide
Root Zone Model) and EXAMS (Exposure Analysis Modeling System) for use
in the human health risk assessment. In this assessment, the EDWCs were
calculated to reflect Bayer's July 2006 mitigation proposal to reduce
the golf course use pattern to 2 applications at 2.7 lbs ai/A and a golf
course adjustment factor (GCAFs) was applied to surface water. The
PRZM-EXAMS surface water modeling data point estimate from the 1 in 10
year annual concentration for FL turf was 19.633 ppb and used in the
chronic dietary exposure assessment.

**IV. Toxicological Information**

Both the acute and chronic dietary exposure estimates for triadimefon
were evaluated based on a NOAEL of 3.4 mg/kg/day from a subchronic
neurotoxicity study in rats (R. Griffin, D325542, 23-JAN-2006). The
triadimefon risk assessments are based on the dietary endpoint only
except for short-term dermal assessment which relied on a 21-day rat
dermal toxicity study having a NOAEL of 300 mg/kg/day. There are no
residential exposures resulting from registered uses of triadimenol. A
summary of the toxicological doses and endpoints selected for these risk
assessments is provided in Table 2.

+-------------+----------------+--------------+-----------------------+
| > **Table   |                |              |                       |
| > 2:        |                |              |                       |
| > Summary   |                |              |                       |
| > of        |                |              |                       |
| > To        |                |              |                       |
| xicological |                |              |                       |
| > Doses and |                |              |                       |
| > Endpoints |                |              |                       |
| > for       |                |              |                       |
| >           |                |              |                       |
| Triadimefon |                |              |                       |
| > and       |                |              |                       |
| > Tr        |                |              |                       |
| iadimenol** |                |              |                       |
+=============+================+==============+=======================+
| *           | **Dose Used in | **FQPA SF\*  | **Study and           |
| *Exposure** | Risk           | and Level of | Toxicological         |
|             | Assessment,    | Concern for  | Effects**             |
| *           | UF**           | Risk         |                       |
| *Scenario** |                | Assessment** |                       |
+-------------+----------------+--------------+-----------------------+
| Acute       | NOAEL = 3.4    | FQPA SF = 1X | Subchronic            |
| Dietary     | mg/kg/day      |              | neurotoxicity study   |
|             |                | aPAD =       | in rats.              |
| (general    | UF = 1000      | [acute       |                       |
| population) |                | RfD]         | LOAEL = 54.6/68.7     |
|             | Acute RfD =    | {.underline} | mg/kg/day based       |
|             | 0.0034         |              | largely on            |
|             | mg/kg/day      | FQPA SF      | hyperactivity.        |
|             |                |              |                       |
|             |                | aPAD =       |                       |
|             |                | 0.0034       |                       |
|             |                | mg/kg/day    |                       |
+-------------+----------------+--------------+-----------------------+
| Chronic     | NOAEL = 3.4    | FQPA SF = 1X | Subchronic            |
| Dietary     | mg/kg/day      |              | neurotoxicity study   |
|             |                | PAD =        | in rats.              |
| (all        | UF = 1000      | [chronic     |                       |
| p           |                | RfD]         | LOAEL = 54.6/68.7     |
| opulations) | Chronic RfD =  | {.underline} | mg/kg/day based       |
|             | 0.0034         |              | largely on            |
|             | mg/kg/day      | FQPA SF      | hyperactivity.        |
|             |                |              |                       |
|             |                | cPAD =       |                       |
|             |                | 0.0034       |                       |
|             |                | mg/kg/day    |                       |
+-------------+----------------+--------------+-----------------------+
| Incidental  | NOAEL = 3.4    | Residential  | Subchronic            |
| Oral        | mg/kg/day      |              | neurotoxicity study   |
| Short-Term  |                | MOE = 1000   | in rats.              |
|             | UF = 1000      |              |                       |
| (1 - 30     |                |              | LOAEL = 54.6/68.7     |
| days)       |                |              | mg/kg/day based       |
|             |                |              | largely on            |
|             |                |              | hyperactivity.        |
+-------------+----------------+--------------+-----------------------+
| Incidental  | NOAEL = 3.4    | Residential  | Subchronic            |
| Oral        | mg/kg/day      |              | neurotoxicity study   |
| Interm      |                | MOE = 1000   | in rats.              |
| ediate-Term | UF = 1000      |              |                       |
|             |                |              | LOAEL = 54.6/68.7     |
| (1 - 6      |                |              | mg/kg/day based       |
| months)     |                |              | largely on            |
|             |                |              | hyperactivity.        |
+-------------+----------------+--------------+-----------------------+
| Dermal      | Dermal NOAEL = | Residential  | 21 Day Dermal         |
|             | 300 mg/kg/day  |              | Toxicity in rabbits.  |
| Short-Term  |                | MOE = 1000   |                       |
|             |                |              | The LOAEL= 1000       |
| (1 - 30     |                | Occupational | mg/kg/day based on    |
| days)       |                |              | increased reactivity  |
|             |                | MOE = 100    | and activity in the   |
|             |                |              | females.              |
+-------------+----------------+--------------+-----------------------+
| Dermal      | Dermal NOAEL = | Residential  | 21 Day Dermal         |
|             | 300 mg/kg/day  |              | Toxicity in rabbits.  |
| Interm      |                | MOE = 1000   |                       |
| ediate-Term |                |              | The LOAEL= 1000       |
|             |                | Occupational | mg/kg/day based on    |
| (1 - 6      |                |              | increased reactivity  |
| months)     |                | MOE = 100    | and activity in the   |
|             |                |              | females.              |
+-------------+----------------+--------------+-----------------------+
| Dermal      | Not Applicable | Not          | Quantitative risk     |
|             |                | Applicable   | assessment is not     |
| Long-Term   |                |              | required since no     |
|             |                |              | long- term dermal     |
| (\> 6       |                |              | exposure is expected. |
| months)     |                |              |                       |
+-------------+----------------+--------------+-----------------------+
| Inhalation  | NOAEL = 3.4    | Residential  | Subchronic            |
|             | mg/kg/day      |              | neurotoxicity study   |
| Short-Term  |                | MOE = 1000   | in rats.              |
|             | (Inhalation    |              |                       |
| (1 - 30     | absorption     | Occupational | LOAEL = 54.6/68.7     |
| days)       | rate = 100%)   |              | mg/kg/day based       |
|             |                | MOE = 100    | largely on            |
|             |                |              | hyperactivity.        |
+-------------+----------------+--------------+-----------------------+
| Inhalation  | NOAEL = 3.4    | Residential  | Subchronic            |
|             | mg/ kg/day     |              | neurotoxicity study   |
| Interm      |                | MOE = 1000   | in rats.              |
| ediate-Term | (Inhalation    |              |                       |
|             | absorption     | Occupational | LOAEL = 54.6/68.7     |
| (1 - 6      | rate = 100%)   |              | mg/kg/day based       |
| months)     |                | MOE = 100    | largely on            |
|             |                |              | hyperactivity.        |
+-------------+----------------+--------------+-----------------------+
| Inhalation  | Not Applicable | Not          | Quantitative risk     |
|             |                | Applicable   | assessment is not     |
| Long-Term   |                |              | required since no     |
|             |                |              | long- term exposure   |
| (\> 6       |                |              | is expected.          |
| months)     |                |              |                       |
+-------------+----------------+--------------+-----------------------+
| Cancer      | C              |              |                       |
| (oral,      | lassification: |              |                       |
| dermal,     | Category C     |              |                       |
| inhalation) | "possible      |              |                       |
|             | human          |              |                       |
|             | carcinogen"    |              |                       |
|             | based on       |              |                       |
|             | statistically  |              |                       |
|             | significant    |              |                       |
|             | increase in    |              |                       |
|             | thyroid        |              |                       |
|             | adenomas in    |              |                       |
|             | male Wistar    |              |                       |
|             | rats and       |              |                       |
|             | statistically  |              |                       |
|             | significant    |              |                       |
|             | increases in   |              |                       |
|             | hepatocellular |              |                       |
|             | adenomas in    |              |                       |
|             | both sexes of  |              |                       |
|             | the NMRI       |              |                       |
|             | mouse.         |              |                       |
+-------------+----------------+--------------+-----------------------+

UF = uncertainty factor, FQPA SF = FQPA safety factor, NOAEL = no
observed adverse effect level, LOAEL = lowest observed adverse effect
level, PAD = population adjusted dose (a = acute, c = chronic) RfD =
reference dose, MOE = margin of exposure, LOC = level of concern, NA =
Not Applicable

**V. Results/Discussion**

As stated above, for acute and chronic assessments, HED is concerned
when dietary risk exceeds 100% of the PAD. The DEEM-FCID analyses
estimate the dietary exposure of the U.S. population and various
population subgroups. The acute and chronic dietary exposure analyses
reported in Tables 3-4 for the general U.S. population, all infants
(less than 1 year old), children 1-2, children 3-5, children 6-12, youth
13-19, adults 20-49, adults 50+ years, and females 13-49.

The acute aggregate dietary exposure estimates from food only are below
HED's level of concern (\<100% aPAD) at the 95^[th]{.underline}^
percentile of exposure. The acute aggregate dietary risk at the
95^[th]{.underline}^ percentile of exposure from food only is 15% of the
aPAD for the U.S. population and 32% of the aPAD for children 1-2 yrs,
the most highly exposed population subgroup (see Table 3).

The acute aggregate dietary exposure estimates from drinking water only
using the Florida turf (two applications) for drinking water are below
HED's level of concern (\<100% aPAD) at the 95^[th]{.underline}^
percentile of exposure. At the 95^[th]{.underline}^ percentile of
exposure risks were estimated to be 24% and 85% of the aPAD for the U.S.
population and all infants (\<1 yr), respectively (see attachment 10).

The acute aggregate dietary exposure estimates from food and drinking
water using Florida turf with two applications for drinking water are
below HED's level of concern (\<100% aPAD) at the 95^[th]{.underline}^
percentile of exposure. At the 95^[th]{.underline}^ percentile of
exposure risks were estimated to be 33% and 94% of the aPAD for the U.S.
population and all infants (\<1 yr), respectively (see Table 3).

  ---------------------------------------------------------------------------------------
  **Table 3.                                                                    
  Results of                                                                    
  Aggregate Acute                                                               
  Dietary Exposure                                                              
  Analysis for                                                                  
  Using DEEM-FCID**                                                             
  ----------------- --------------- --------------- ----------- --------------- ---------
  **Population      **aPAD          **Food Only**               **Food +        
  Subgroup**        (mg/kg/day)**                               Drinking        
                                                                Water**         

                                    **95^th^                    **95^h^         
                                    Percentile**                Percentile**    

                                    **Exposure      **% aPAD**  **Exposure      **%
                                    (mg/kg/day)**               (mg/kg/day)**   aPAD**

  General U.S.      0.0034          0.000520        15.29       0.001106        32.52
  Population                                                                    

  All Infants (\< 1 0.0034          0.000828        24.36       0.003190        93.82
  year old)                                                                     

  Children 1-2      0.0034          0.001083        31.86       0.001959        57.63
  years old                                                                     

  Children 3-5      0.0034          0.000923        27.16       0.001765        51.92
  years old                                                                     

  Children 6-12     0.0034          0.000668        19.64       0.001210        35.58
  years old                                                                     

  Youth 13-19 years 0.0034          0.000440        12.95       0.000859        25.28
  old                                                                           

  Adults 20-49      0.0034          0.000334        9.82        0.000942        27.72
  years old                                                                     

  Adults 50+ years  0.0034          0.000249        7.33        0.000921        27.10
  old                                                                           

  Females 13-49     0.0034          0.000322        9.47        0.000936        27.52
  year old                                                                      
  ---------------------------------------------------------------------------------------

The chronic aggregate dietary exposure estimates from food only are
below HED's level of concern (\<100% cPAD) for the U.S. population and
all population subgroups. The chronic aggregate dietary risk from food
only for the U.S. population is 6% of the cPAD and 15% of the cPAD for
children 1-2 yrs, the most highly exposed population subgroup (see Table
4).

The chronic aggregate dietary exposure estimates from drinking water
only using the Florida turf with two applications, are below HED's level
of concern (\<100% cPAD) for the U.S. population and all population
subgroups. The aggregate dietary risk from drinking water for the U.S.
population is 12% of the cPAD and 40% of the cPAD for all infants (\<1
yr), the most highly exposed population subgroup (see Attachment 12).

The chronic aggregate dietary exposure estimates from food and drinking
water using Florida turf, two applications are below HED's level of
concern (\<100% cPAD) for the U.S. population and all population
subgroups. The aggregate dietary risk from food and drinking water for
the U.S. population is 18% of the cPAD and 47% of the cPAD for all
infants (\<1 yr), the most highly exposed population subgroup (see Table
4).

<table style="width:100%;">
<colgroup>
<col style="width: 25%" />
<col style="width: 0%" />
<col style="width: 0%" />
<col style="width: 17%" />
<col style="width: 0%" />
<col style="width: 0%" />
<col style="width: 18%" />
<col style="width: 0%" />
<col style="width: 8%" />
<col style="width: 0%" />
<col style="width: 0%" />
<col style="width: 18%" />
<col style="width: 0%" />
<col style="width: 8%" />
</colgroup>
<thead>
<tr class="header">
<th colspan="14"><strong>Table 4. Results of Aggregate Chronic Dietary
Risk Analysis from (Food Alone) and (Food + Drinking Water- Entire
Course) Using DEEM-FCID</strong></th>
</tr>
<tr class="odd">
<th colspan="2"><strong>Population Subgroup</strong></th>
<th colspan="3"><strong>cPAD (mg/kg/day)</strong></th>
<th colspan="5"><strong>Food Alone</strong></th>
<th colspan="4"><p><strong>Food + Drinking Water</strong></p>
<p><strong>(Entire Course)</strong></p></th>
</tr>
<tr class="header">
<th colspan="3"></th>
<th colspan="3"></th>
<th colspan="2"><strong>Exposure (mg/kg/day)</strong></th>
<th colspan="3"><strong>% cPAD</strong></th>
<th colspan="2"><strong>Exposure (mg/kg/day)</strong></th>
<th><strong>% cPAD</strong></th>
</tr>
</thead>
<tbody>
<tr class="odd">
<td>General U.S. Population</td>
<td colspan="3">0.0034</td>
<td colspan="3">0.000194</td>
<td colspan="2">5.7%</td>
<td colspan="3">0.000607</td>
<td colspan="2">17.9%</td>
</tr>
<tr class="even">
<td>All Infants (&lt; 1 year old)</td>
<td colspan="3">0.0034</td>
<td colspan="3">0.000227</td>
<td colspan="2">6.7%</td>
<td colspan="3">0.001584</td>
<td colspan="2">46.6%</td>
</tr>
<tr class="odd">
<td>Children 1-2 years old</td>
<td colspan="3">0.0034</td>
<td colspan="3">0.000493</td>
<td colspan="2">14.5%</td>
<td colspan="3">0.001108</td>
<td colspan="2">32.6%</td>
</tr>
<tr class="even">
<td>Children 3-5 years old</td>
<td colspan="3">0.0034</td>
<td colspan="3">0.000471</td>
<td colspan="2">13.9%</td>
<td colspan="3">0.001047</td>
<td colspan="2">30.8%</td>
</tr>
<tr class="odd">
<td>Children 6-12 years old</td>
<td colspan="3">0.0034</td>
<td colspan="3">0.000323</td>
<td colspan="2">9.5%</td>
<td colspan="3">0.000720</td>
<td colspan="2">21.2%</td>
</tr>
<tr class="even">
<td>Youth 13-19 years old</td>
<td colspan="3">0.0034</td>
<td colspan="3">0.000203</td>
<td colspan="2">6.0%</td>
<td colspan="3">0.000503</td>
<td colspan="2">14.8%</td>
</tr>
<tr class="odd">
<td>Adults 20-49 years old</td>
<td colspan="3">0.0034</td>
<td colspan="3">0.000154</td>
<td colspan="2">4.5%</td>
<td colspan="3">0.000540</td>
<td colspan="2">15.9%</td>
</tr>
<tr class="even">
<td>Adults 50+ years old</td>
<td colspan="3">0.0034</td>
<td colspan="3">0.000117</td>
<td colspan="2">3.4%</td>
<td colspan="3">0.00052</td>
<td colspan="2">15.4%</td>
</tr>
<tr class="odd">
<td>Females 13-49 year old</td>
<td colspan="3">0.0034</td>
<td colspan="3">0.000147</td>
<td colspan="2">4.3%</td>
<td colspan="3">0.000532</td>
<td colspan="2">15.6%</td>
</tr>
</tbody>
</table>

The short-term aggregate risk reflecting residential handler scenarios:
Application to ornamentals (azaleas = worst case residential handler
(MOE of 1100 for dermal + inhalation). The resulting short-term
aggregate has a MOE of 920 which exceeds HED level of concern. Another
scenario residential handler (mixer, loader, applicator) for
low-pressure hand-wand application of a WP to green house ornamental has
a MOE of 1700 (dermal + inhalation).  The resulting short --term
aggregate MOE is 1300.

Short-term aggregate for toddlers due to post-application exposure to
treated sod (i.e. sod transplanted to a residential lawn). The MOE
(combined hand-to-mouth, dermal and inhalation) at a sod pre-harvest
interval of 15 days was 1100; the MOE was of concern (\<1000) at 14
days.  The chronic dietary (food + water) exposure for children 1-2
years is a MOE of 3100.  The resulting short-term aggregate MOE was 810.

On day 17, the combined MOE's for toddlers on sod treated at the 2.7 lb
a.i./A rate is 1700. When this rate is aggregated with the chronic
dietary (food and water) MOE of 3100 MOE, the resultant aggregate is
1100. The individual MOE's are as follows: a) Hand-To-Mouth = 2500; b)
Object-To-Mouth = 10,000; c) Soil = 31,000; Dermal = 11,000. The
short-term toddler aggregate on day 16 is 920.

**VI. List of Attachments**

Attachment 1 Acute Aggregate (food only) Residue Input Data

Attachment 2 Acute Aggregate (food only) Residue Analysis

Attachment 3 Acute Aggregate (food + water) Residue Input Data

Attachment 4 Acute Aggregate (food + water) Residue Analysis

Attachment 5 Chronic Aggregate (food only) Residue Input Data

Attachment 6 Chronic Aggregate (food only) Residue Analysis

Attachment 7 Chronic Aggregate (food + water) Residue Input Data

Attachment 8 Chronic Aggregate (food + water) Residue Analysis

Attachment 9 Acute Aggregate (Water only) Residue Input Data

Attachment 10 Acute Aggregate (Water only) Residue Analysis

Attachment 11 Chronic Aggregate (Water only) Residue Input Data

Attachment 12 Chronic Aggregate (Water only) Residue Analysis

Attachment 13 Short-Term Aggregate Calculations

cc: S. Piper, CEB Reading Files; Y. Barnes, RRB2 Reading Files

RDI: 08/01/06 William Hazel; Richard Griffin 08/01/06; David Miller
08/02/06

7509P: CEB PY-Room 10244: 308-2717: Triadimefon/Triadimenol

**Attachment 1: Acute Aggregate (food only) Residue Input Data**

U.S. Environmental Protection Agency Ver. 2.02

DEEM-FCID Acute analysis for TRIADIMEFON

Residue file name: C:\\Documents and
Settings\\spiper\\SPIPER\\triadimenol\\AggregateFoodonly_7242006.R98

Analysis Date 07-25-2006 Residue file dated: 07-25-2006/09:23:21/8

Reference dose (aRfD) = 0.0034 mg/kg bw/day

Comment: Triadimefon + Triadimenol \[food only\]

\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--

RDL indices and parameters for Monte Carlo Analysis:

Index Dist Parameter #1 Param #2 Param #3 Comment

\# Code

\-\-\-\-- \-\-\-- \-\-\-\-\-\-\-\-\-\-\-- \-\-\-\-\-\-\-\-\-\--
\-\-\-\-\-\-\-\-\-\-- \-\-\-\-\-\-\-\-\--

1 6 Apple, NB or PB 6 21 2006.rdf

2 6 Apple, B - 6 21 2006.rdf

3 6 GrapesPB 6 21 2006.rdf

4 6 Pear, NB or PB 6 21 2006.rdf

5 6 Pineapples, FT 6 21 2006.rdf

6 6 new FDA Raspberry 06 29 2006.rdf

7 6 Banana, PBNB-FT 6 21 2006.rdf

8 6 FLturf2applmaxDW_triadimefon.rdf

EPA Crop Food Name Def Res Adj.Factors RDL Comment

Code Grp (ppm) #1 #2 Pntr

\-\-\-\-\-\-\-- \-\-\--
\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--
\-\-\-\-\-\-\-\-\-- \-\-\-\-\-- \-\-\-\-\-- \-\-- \-\-\-\-\-\--

95000230 O Banana 0.030000 1.000 1.000 7

95000231 O Banana-babyfood 0.030000 1.000 1.000 7

95000240 O Banana, dried 0.030000 3.900 1.000

95000241 O Banana, dried-babyfood 0.030000 3.900 1.000

15000250 15 Barley, pearled barley 0.050000 1.000 1.000

15000251 15 Barley, pearled barley-babyfood 0.050000 1.000 1.000

15000260 15 Barley, flour 0.050000 1.000 1.000

15000261 15 Barley, flour-babyfood 0.050000 1.000 1.000

15000270 15 Barley, bran 0.050000 2.100 1.000

15001200 15 Corn, field, flour 0.050000 1.000 1.000

15001201 15 Corn, field, flour-babyfood 0.050000 1.000 1.000

15001210 15 Corn, field, meal 0.050000 1.000 1.000

15001211 15 Corn, field, meal-babyfood 0.050000 1.000 1.000

15001220 15 Corn, field, bran 0.050000 1.000 1.000

15001230 15 Corn, field, starch 0.050000 1.000 1.000

15001231 15 Corn, field, starch-babyfood 0.050000 1.000 1.000

15001240 15 Corn, field, syrup 0.050000 1.000 1.000

15001241 15 Corn, field, syrup-babyfood 0.050000 1.000 1.000

15001250 15 Corn, field, oil 0.050000 1.000 1.000

15001251 15 Corn, field, oil-babyfood 0.050000 1.000 1.000

15001260 15 Corn, pop 0.050000 1.000 1.000

15001270 15 Corn, sweet 0.050000 1.000 1.000

15001271 15 Corn, sweet-babyfood 0.050000 1.000 1.000

95001280 O Cottonseed, oil 0.020000 1.000 1.000

95001281 O Cottonseed, oil-babyfood 0.020000 1.000 1.000

15002310 15 Oat, bran 0.050000 2.100 1.000

15002320 15 Oat, flour 0.050000 1.000 1.000

15002321 15 Oat, flour-babyfood 0.050000 1.000 1.000

15002330 15 Oat, groats/rolled oats 0.050000 1.000 1.000

15002331 15 Oat, groats/rolled oats-babyfood 0.050000 1.000 1.000

95002790 O Pineapple 0.079000 1.000 1.000 5

95002791 O Pineapple-babyfood 0.079000 1.000 1.000 5

95002800 O Pineapple, dried 0.079000 1.000 1.000 5

95002810 O Pineapple, juice 0.079000 1.000 1.000 5

95002811 O Pineapple, juice-babyfood 0.079000 1.000 1.000 5

15003280 15 Rye, grain 0.050000 1.000 1.000

15003290 15 Rye, flour 0.050000 1.000 1.000

15004010 15 Wheat, grain 0.050000 1.000 1.000

15004011 15 Wheat, grain-babyfood 0.050000 1.000 1.000

15004020 15 Wheat, flour 0.050000 1.000 1.000

15004021 15 Wheat, flour-babyfood 0.050000 1.000 1.000

15004030 15 Wheat, germ 0.050000 1.000 1.000

15004040 15 Wheat, bran 0.050000 2.100 1.000

**Attachment 2: Acute Aggregate (food only) Residue Analysis**

U.S. Environmental Protection Agency Ver. 2.02

DEEM-FCID ACUTE Analysis for TRIADIMEFON (1994-98 data)

Residue file: AggregateFoodonly_7242006.R98 Adjustment factor #2 used.

Analysis Date: 07-25-2006/09:27:48 Residue file dated:
07-25-2006/09:23:21/8

Daily totals for food and foodform consumption used.

MC iterations = 1000 MC list in residue file MC seed = 10

Run Comment: \"Triadimefon + Triadimenol \[food only\]\"

===============================================================================

Summary calculations (per capita):

95th Percentile 99th Percentile 99.9th Percentile

Exposure % aRfD Exposure % aRfD Exposure % aRfD

\-\-\-\-\-\-\-\-\-- \-\-\-\-\-\-\-- \-\-\-\-\-\-\-\-\-- \-\-\-\-\-\-\--
\-\-\-\-\-\-\-\-\-- \-\-\-\-\-\-\--

U.S. Population:

0.000520 15.29 0.000855 25.14 0.001490 43.82

All infants:

0.000828 24.36 0.001298 38.18 0.002021 59.44

Children 1-2 yrs:

0.001083 31.86 0.001681 49.45 0.002720 80.01

Children 3-5 yrs:

0.000923 27.16 0.001289 37.90 0.002230 65.58

Children 6-12 yrs:

0.000668 19.64 0.000931 27.39 0.001446 42.54

Youth 13-19 yrs:

0.000440 12.95 0.000646 19.00 0.001076 31.64

Adults 20-49 yrs:

0.000334 9.82 0.000516 15.17 0.000865 25.43

Adults 50+ yrs:

0.000249 7.33 0.000350 10.29 0.000548 16.11

Females 13-49 yrs:

0.000322 9.47 0.000479 14.09 0.001134 33.36

**Attachment 3: Acute Aggregate (food + water) Residue Input Data**

U.S. Environmental Protection Agency Ver. 2.02

DEEM-FCID Acute analysis for TRIADIMEFON

Residue file name: C:\\Documents and
Settings\\spiper\\SPIPER\\triadimenol\\AggregateFLturf2app_7242006.R98

Analysis Date 07-25-2006 Residue file dated: 07-25-2006/10:04:48/8

Reference dose (aRfD) = 0.0034 mg/kg bw/day

Comment: Triadimefon + Triadimenol \[food + FL turf 2 appl max\]

\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--

RDL indices and parameters for Monte Carlo Analysis:

Index Dist Parameter #1 Param #2 Param #3 Comment

\# Code

\-\-\-\-- \-\-\-- \-\-\-\-\-\-\-\-\-\-\-- \-\-\-\-\-\-\-\-\-\--
\-\-\-\-\-\-\-\-\-\-- \-\-\-\-\-\-\-\-\--

1 6 Apple, NB or PB 6 21 2006.rdf

2 6 Apple, B - 6 21 2006.rdf

3 6 GrapesPB 6 21 2006.rdf

4 6 Pear, NB or PB 6 21 2006.rdf

5 6 Pineapples, FT 6 21 2006.rdf

6 6 new FDA Raspberry 06 29 2006.rdf

7 6 Banana, PBNB-FT 6 21 2006.rdf

8 6 FLturf2applmaxDW_triadimefon.rdf

EPA Crop Food Name Def Res Adj.Factors RDL Comment

Code Grp (ppm) #1 #2 Pntr

\-\-\-\-\-\-\-- \-\-\--
\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--
\-\-\-\-\-\-\-\-\-- \-\-\-\-\-- \-\-\-\-\-- \-\-- \-\-\-\-\-\--

95000230 O Banana 0.030000 1.000 1.000 7

95000231 O Banana-babyfood 0.030000 1.000 1.000 7

95000240 O Banana, dried 0.030000 3.900 1.000

95000241 O Banana, dried-babyfood 0.030000 3.900 1.000

15000250 15 Barley, pearled barley 0.050000 1.000 1.000

15000251 15 Barley, pearled barley-babyfood 0.050000 1.000 1.000

15000260 15 Barley, flour 0.050000 1.000 1.000

15000261 15 Barley, flour-babyfood 0.050000 1.000 1.000

15000270 15 Barley, bran 0.050000 2.100 1.000

15001200 15 Corn, field, flour 0.050000 1.000 1.000

15001201 15 Corn, field, flour-babyfood 0.050000 1.000 1.000

15001210 15 Corn, field, meal 0.050000 1.000 1.000

15001211 15 Corn, field, meal-babyfood 0.050000 1.000 1.000

15001220 15 Corn, field, bran 0.050000 1.000 1.000

15001230 15 Corn, field, starch 0.050000 1.000 1.000

15001231 15 Corn, field, starch-babyfood 0.050000 1.000 1.000

15001240 15 Corn, field, syrup 0.050000 1.000 1.000

15001241 15 Corn, field, syrup-babyfood 0.050000 1.000 1.000

15001250 15 Corn, field, oil 0.050000 1.000 1.000

15001251 15 Corn, field, oil-babyfood 0.050000 1.000 1.000

15001260 15 Corn, pop 0.050000 1.000 1.000

15001270 15 Corn, sweet 0.050000 1.000 1.000

15001271 15 Corn, sweet-babyfood 0.050000 1.000 1.000

95001280 O Cottonseed, oil 0.020000 1.000 1.000

95001281 O Cottonseed, oil-babyfood 0.020000 1.000 1.000

15002310 15 Oat, bran 0.050000 2.100 1.000

15002320 15 Oat, flour 0.050000 1.000 1.000

15002321 15 Oat, flour-babyfood 0.050000 1.000 1.000

15002330 15 Oat, groats/rolled oats 0.050000 1.000 1.000

15002331 15 Oat, groats/rolled oats-babyfood 0.050000 1.000 1.000

95002790 O Pineapple 0.100000 1.000 1.000 5

95002791 O Pineapple-babyfood 0.100000 1.000 1.000 5

95002800 O Pineapple, dried 0.100000 1.000 1.000 5

95002810 O Pineapple, juice 0.100000 1.000 1.000 5

95002811 O Pineapple, juice-babyfood 0.100000 1.000 1.000 5

15003280 15 Rye, grain 0.050000 1.000 1.000

15003290 15 Rye, flour 0.050000 1.000 1.000

86010000 O Water, direct, all sources 0.010000 1.000 1.000 8

86020000 O Water, indirect, all sources 0.010000 1.000 1.000 8

15004010 15 Wheat, grain 0.050000 1.000 1.000

15004011 15 Wheat, grain-babyfood 0.050000 1.000 1.000

15004020 15 Wheat, flour 0.050000 1.000 1.000

15004021 15 Wheat, flour-babyfood 0.050000 1.000 1.000

15004030 15 Wheat, germ 0.050000 1.000 1.000

15004040 15 Wheat, bran 0.050000 2.100 1.000

**Attachment 4: Acute Aggregate (food + water) Residue Analysis**

U.S. Environmental Protection Agency Ver. 2.02

DEEM-FCID ACUTE Analysis for TRIADIMEFON (1994-98 data)

Residue file: AggregateFLturf2app_7242006.R98 Adjustment factor #2 used.

Analysis Date: 07-25-2006/10:09:57 Residue file dated:
07-25-2006/10:04:48/8

Daily totals for food and foodform consumption used.

MC iterations = 1000 MC list in residue file MC seed = 10

Run Comment: \"Triadimefon + Triadimenol \[food + FL turf 2 appl max\]\"

===============================================================================

Summary calculations (per capita):

95th Percentile 99th Percentile 99.9th Percentile

Exposure % aRfD Exposure % aRfD Exposure % aRfD

\-\-\-\-\-\-\-\-\-- \-\-\-\-\-\-\-- \-\-\-\-\-\-\-\-\-- \-\-\-\-\-\-\--
\-\-\-\-\-\-\-\-\-- \-\-\-\-\-\-\--

U.S. Population:

0.001106 32.52 0.002350 69.11 0.005541 162.98

All infants:

0.003190 93.82 0.007747 227.87 0.017654 519.24

Children 1-2 yrs:

0.001959 57.63 0.003817 112.26 0.008347 245.51

Children 3-5 yrs:

0.001765 51.92 0.003482 102.42 0.007469 219.69

Children 6-12 yrs:

0.001210 35.58 0.002400 70.58 0.005175 152.20

Youth 13-19 yrs:

0.000859 25.28 0.001802 53.00 0.004235 124.57

Adults 20-49 yrs:

0.000942 27.72 0.002085 61.33 0.004808 141.40

Adults 50+ yrs:

0.000921 27.10 0.001982 58.29 0.004131 121.50

Females 13-49 yrs:

0.000936 27.52 0.002087 61.39 0.004779 140.55

**Attachment 5: Chronic Aggregate (food only) Residue Input Data**

U.S. Environmental Protection Agency Ver. 2.00

DEEM-FCID Chronic analysis for TRIADIMEFON 1994-98 data

Residue file: C:\\Documents and
Settings\\spiper\\SPIPER\\triadimenol\\aggregatelFoodonly_chronic7242006.R98

Adjust. #2 used

Analysis Date 07-25-2006 Residue file dated: 07-25-2006/09:36:52/8

Reference dose (RfD) = 0.0034 mg/kg bw/day

Comment:Chronic: Triadimefon +Triadimenol food only

\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--

Food Crop Residue Adj.Factors Comment

EPA Code Grp Food Name (ppm)

#1 #2

\-\-\-\-\-\-\-- \-\-\--
\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--
\-\-\-\-\-\-\-\-\-- \-\-\-\-\-- \-\-\-\-\-- \-\-\-\-\-\--

95000230 O Banana 0.030000 1.000 1.000

95000231 O Banana-babyfood 0.030000 1.000 1.000

95000240 O Banana, dried 0.030000 3.900 1.000

95000241 O Banana, dried-babyfood 0.030000 3.900 1.000

15000250 15 Barley, pearled barley 0.050000 1.000 1.000

15000251 15 Barley, pearled barley-babyfood 0.050000 1.000 1.000

15000260 15 Barley, flour 0.050000 1.000 1.000

15000261 15 Barley, flour-babyfood 0.050000 1.000 1.000

15000270 15 Barley, bran 0.050000 2.100 1.000

15001200 15 Corn, field, flour 0.050000 1.000 1.000

15001201 15 Corn, field, flour-babyfood 0.050000 1.000 1.000

15001210 15 Corn, field, meal 0.050000 1.000 1.000

15001211 15 Corn, field, meal-babyfood 0.050000 1.000 1.000

15001220 15 Corn, field, bran 0.050000 1.000 1.000

15001230 15 Corn, field, starch 0.050000 1.000 1.000

15001231 15 Corn, field, starch-babyfood 0.050000 1.000 1.000

15001240 15 Corn, field, syrup 0.050000 1.000 1.000

15001241 15 Corn, field, syrup-babyfood 0.050000 1.000 1.000

15001250 15 Corn, field, oil 0.050000 1.000 1.000

15001251 15 Corn, field, oil-babyfood 0.050000 1.000 1.000

15001260 15 Corn, pop 0.050000 1.000 1.000

15001270 15 Corn, sweet 0.050000 1.000 1.000

15001271 15 Corn, sweet-babyfood 0.050000 1.000 1.000

95001280 O Cottonseed, oil 0.020000 1.000 1.000

95001281 O Cottonseed, oil-babyfood 0.020000 1.000 1.000

15002310 15 Oat, bran 0.050000 2.100 1.000

15002320 15 Oat, flour 0.050000 1.000 1.000

15002321 15 Oat, flour-babyfood 0.050000 1.000 1.000

15002330 15 Oat, groats/rolled oats 0.050000 1.000 1.000

15002331 15 Oat, groats/rolled oats-babyfood 0.050000 1.000 1.000

95002790 O Pineapple 0.079000 1.000 1.000

95002791 O Pineapple-babyfood 0.079000 1.000 1.000

95002800 O Pineapple, dried 0.079000 5.000 1.000

95002810 O Pineapple, juice 0.079000 1.000 1.000

95002811 O Pineapple, juice-babyfood 0.079000 1.000 1.000

15003280 15 Rye, grain 0.050000 1.000 1.000

15003290 15 Rye, flour 0.050000 1.000 1.000

15004010 15 Wheat, grain 0.050000 1.000 1.000

15004011 15 Wheat, grain-babyfood 0.050000 1.000 1.000

15004020 15 Wheat, flour 0.050000 1.000 1.000

15004021 15 Wheat, flour-babyfood 0.050000 1.000 1.000

15004030 15 Wheat, germ 0.050000 1.000 1.000

15004040 15 Wheat, bran 0.050000 2.100 1.000

**Attachment 6: Chronic Aggregate (food only) Residue Analysis**

U.S. Environmental Protection Agency Ver. 2.00

DEEM-FCID Chronic analysis for TRIADIMEFON (1994-98 data)

Residue file name: C:\\Documents and
Settings\\spiper\\SPIPER\\triadimenol\\aggregatelFoodonly_chronic7242006.R98

Adjustment factor #2 used.

Analysis Date 07-25-2006/09:37:36 Residue file dated:
07-25-2006/09:36:52/8

Reference dose (RfD, Chronic) = .0034 mg/kg bw/day

COMMENT 1: Chronic: Triadimefon +Triadimenol food only

===============================================================================

Total exposure by population subgroup

\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--

Total Exposure

\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--

Population mg/kg Percent of

Subgroup body wt/day Rfd

\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--
\-\-\-\-\-\-\-\-\-\-\-\-- \-\-\-\-\-\-\-\-\-\-\-\-\-\--

U.S. Population (total) 0.000194 5.7%

U.S. Population (spring season) 0.000196 5.8%

U.S. Population (summer season) 0.000196 5.8%

U.S. Population (autumn season) 0.000190 5.6%

U.S. Population (winter season) 0.000192 5.6%

Northeast region 0.000190 5.6%

Midwest region 0.000206 6.1%

Southern region 0.000185 5.4%

Western region 0.000197 5.8%

Hispanics 0.000203 6.0%

Non-hispanic whites 0.000193 5.7%

Non-hispanic blacks 0.000194 5.7%

Non-hisp/non-white/non-black 0.000178 5.2%

All infants (\< 1 year) 0.000227 6.7%

Nursing infants 0.000108 3.2%

Non-nursing infants 0.000272 8.0%

Children 1-6 yrs 0.000467 13.7%

Children 7-12 yrs 0.000309 9.1%

Females 13-19 (not preg or nursing) 0.000177 5.2%

Females 20+ (not preg or nursing) 0.000128 3.8%

Females 13-50 yrs 0.000157 4.6%

Females 13+ (preg/not nursing) 0.000155 4.6%

Females 13+ (nursing) 0.000175 5.2%

Males 13-19 yrs 0.000229 6.7%

Males 20+ yrs 0.000153 4.5%

Seniors 55+ 0.000115 3.4%

Children 1-2 yrs 0.000493 14.5%

Children 3-5 yrs 0.000471 13.9%

Children 6-12 yrs 0.000323 9.5%

Youth 13-19 yrs 0.000203 6.0%

Adults 20-49 yrs 0.000154 4.5%

Adults 50+ yrs 0.000117 3.4%

Females 13-49 yrs 0.000147 4.3%

\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--

**Attachment 7: Chronic Aggregate (food + water) Residue Input Data**

U.S. Environmental Protection Agency Ver. 2.00

DEEM-FCID Chronic analysis for TRIADIMEFON 1994-98 data

Residue file: C:\\Documents and
Settings\\spiper\\SPIPER\\triadimenol\\aggregatelFLturf2app_chronic7242006.R98

Adjust. #2 used

Analysis Date 07-25-2006 Residue file dated: 07-25-2006/10:14:45/8

Reference dose (RfD) = 0.0034 mg/kg bw/day

Comment:Chronic: Triadimefon +Triadimenol food and drinking water\[FL
turf 2 appl max\]

\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--

Food Crop Residue Adj.Factors Comment

EPA Code Grp Food Name (ppm)

#1 #2

\-\-\-\-\-\-\-- \-\-\--
\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--
\-\-\-\-\-\-\-\-\-- \-\-\-\-\-- \-\-\-\-\-- \-\-\-\-\-\--

95000230 O Banana 0.030000 1.000 1.000

95000231 O Banana-babyfood 0.030000 1.000 1.000

95000240 O Banana, dried 0.030000 3.900 1.000

95000241 O Banana, dried-babyfood 0.030000 3.900 1.000

15000250 15 Barley, pearled barley 0.050000 1.000 1.000

15000251 15 Barley, pearled barley-babyfood 0.050000 1.000 1.000

15000260 15 Barley, flour 0.050000 1.000 1.000

15000261 15 Barley, flour-babyfood 0.050000 1.000 1.000

15000270 15 Barley, bran 0.050000 2.100 1.000

15001200 15 Corn, field, flour 0.050000 1.000 1.000

15001201 15 Corn, field, flour-babyfood 0.050000 1.000 1.000

15001210 15 Corn, field, meal 0.050000 1.000 1.000

15001211 15 Corn, field, meal-babyfood 0.050000 1.000 1.000

15001220 15 Corn, field, bran 0.050000 1.000 1.000

15001230 15 Corn, field, starch 0.050000 1.000 1.000

15001231 15 Corn, field, starch-babyfood 0.050000 1.000 1.000

15001240 15 Corn, field, syrup 0.050000 1.000 1.000

15001241 15 Corn, field, syrup-babyfood 0.050000 1.000 1.000

15001250 15 Corn, field, oil 0.050000 1.000 1.000

15001251 15 Corn, field, oil-babyfood 0.050000 1.000 1.000

15001260 15 Corn, pop 0.050000 1.000 1.000

15001270 15 Corn, sweet 0.050000 1.000 1.000

15001271 15 Corn, sweet-babyfood 0.050000 1.000 1.000

95001280 O Cottonseed, oil 0.020000 1.000 1.000

95001281 O Cottonseed, oil-babyfood 0.020000 1.000 1.000

15002310 15 Oat, bran 0.050000 2.100 1.000

15002320 15 Oat, flour 0.050000 1.000 1.000

15002321 15 Oat, flour-babyfood 0.050000 1.000 1.000

15002330 15 Oat, groats/rolled oats 0.050000 1.000 1.000

15002331 15 Oat, groats/rolled oats-babyfood 0.050000 1.000 1.000

95002790 O Pineapple 0.079000 1.000 1.000

95002791 O Pineapple-babyfood 0.079000 1.000 1.000

95002800 O Pineapple, dried 0.079000 5.000 1.000

95002810 O Pineapple, juice 0.079000 1.000 1.000

95002811 O Pineapple, juice-babyfood 0.079000 1.000 1.000

15003280 15 Rye, grain 0.050000 1.000 1.000

15003290 15 Rye, flour 0.050000 1.000 1.000

86010000 O Water, direct, all sources 0.019633 1.000 1.000

86020000 O Water, indirect, all sources 0.019633 1.000 1.000

15004010 15 Wheat, grain 0.050000 1.000 1.000

15004011 15 Wheat, grain-babyfood 0.050000 1.000 1.000

15004020 15 Wheat, flour 0.050000 1.000 1.000

15004021 15 Wheat, flour-babyfood 0.050000 1.000 1.000

15004030 15 Wheat, germ 0.050000 1.000 1.000

15004040 15 Wheat, bran 0.050000 2.100 1.000

**Attachment 8: Chronic Aggregate (food + water) Residue Analysis**

U.S. Environmental Protection Agency Ver. 2.00

DEEM-FCID Chronic analysis for TRIADIMEFON 1994-98 data

Residue file: C:\\Documents and
Settings\\spiper\\SPIPER\\triadimenol\\aggregatelFLturf2app_chronic7242006.R98

Adjust. #2 used

Analysis Date 07-25-2006 Residue file dated: 07-25-2006/10:14:45/8

Reference dose (RfD) = 0.0034 mg/kg bw/day

Comment:Chronic: Triadimefon +Triadimenol food and drinking water\[FL
turf 2 appl max\]

\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--

Food Crop Residue Adj.Factors Comment

EPA Code Grp Food Name (ppm)

#1 #2

\-\-\-\-\-\-\-- \-\-\--
\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--
\-\-\-\-\-\-\-\-\-- \-\-\-\-\-- \-\-\-\-\-- \-\-\-\-\-\--

95000230 O Banana 0.030000 1.000 1.000

95000231 O Banana-babyfood 0.030000 1.000 1.000

95000240 O Banana, dried 0.030000 3.900 1.000

95000241 O Banana, dried-babyfood 0.030000 3.900 1.000

15000250 15 Barley, pearled barley 0.050000 1.000 1.000

15000251 15 Barley, pearled barley-babyfood 0.050000 1.000 1.000

15000260 15 Barley, flour 0.050000 1.000 1.000

15000261 15 Barley, flour-babyfood 0.050000 1.000 1.000

15000270 15 Barley, bran 0.050000 2.100 1.000

15001200 15 Corn, field, flour 0.050000 1.000 1.000

15001201 15 Corn, field, flour-babyfood 0.050000 1.000 1.000

15001210 15 Corn, field, meal 0.050000 1.000 1.000

15001211 15 Corn, field, meal-babyfood 0.050000 1.000 1.000

15001220 15 Corn, field, bran 0.050000 1.000 1.000

15001230 15 Corn, field, starch 0.050000 1.000 1.000

15001231 15 Corn, field, starch-babyfood 0.050000 1.000 1.000

15001240 15 Corn, field, syrup 0.050000 1.000 1.000

15001241 15 Corn, field, syrup-babyfood 0.050000 1.000 1.000

15001250 15 Corn, field, oil 0.050000 1.000 1.000

15001251 15 Corn, field, oil-babyfood 0.050000 1.000 1.000

15001260 15 Corn, pop 0.050000 1.000 1.000

15001270 15 Corn, sweet 0.050000 1.000 1.000

15001271 15 Corn, sweet-babyfood 0.050000 1.000 1.000

95001280 O Cottonseed, oil 0.020000 1.000 1.000

95001281 O Cottonseed, oil-babyfood 0.020000 1.000 1.000

15002310 15 Oat, bran 0.050000 2.100 1.000

15002320 15 Oat, flour 0.050000 1.000 1.000

15002321 15 Oat, flour-babyfood 0.050000 1.000 1.000

15002330 15 Oat, groats/rolled oats 0.050000 1.000 1.000

15002331 15 Oat, groats/rolled oats-babyfood 0.050000 1.000 1.000

95002790 O Pineapple 0.079000 1.000 1.000

95002791 O Pineapple-babyfood 0.079000 1.000 1.000

95002800 O Pineapple, dried 0.079000 5.000 1.000

95002810 O Pineapple, juice 0.079000 1.000 1.000

95002811 O Pineapple, juice-babyfood 0.079000 1.000 1.000

15003280 15 Rye, grain 0.050000 1.000 1.000

15003290 15 Rye, flour 0.050000 1.000 1.000

86010000 O Water, direct, all sources 0.019633 1.000 1.000

86020000 O Water, indirect, all sources 0.019633 1.000 1.000

15004010 15 Wheat, grain 0.050000 1.000 1.000

15004011 15 Wheat, grain-babyfood 0.050000 1.000 1.000

15004020 15 Wheat, flour 0.050000 1.000 1.000

15004021 15 Wheat, flour-babyfood 0.050000 1.000 1.000

15004030 15 Wheat, germ 0.050000 1.000 1.000

15004040 15 Wheat, bran 0.050000 2.100 1.000

**Attachment 9 Acute Aggregate (Water only) Residue Input Data**

U.S. Environmental Protection Agency Ver. 2.02

DEEM-FCID Acute analysis for TRIADIMEFON

Residue file name: C:\\Documents and
Settings\\spiper\\SPIPER\\triadimenol\\AggregateWateronly_7242006.R98

Analysis Date 07-25-2006 Residue file dated: 07-25-2006/09:41:04/8

Reference dose (aRfD) = 0.0034 mg/kg bw/day

Comment: Triadimefon + Triadimenol \[drinking water only\]

\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--

RDL indices and parameters for Monte Carlo Analysis:

Index Dist Parameter #1 Param #2 Param #3 Comment

\# Code

\-\-\-\-- \-\-\-- \-\-\-\-\-\-\-\-\-\-\-- \-\-\-\-\-\-\-\-\-\--
\-\-\-\-\-\-\-\-\-\-- \-\-\-\-\-\-\-\-\--

1 6 Apple, NB or PB 6 21 2006.rdf

2 6 Apple, B - 6 21 2006.rdf

3 6 GrapesPB 6 21 2006.rdf

4 6 Pear, NB or PB 6 21 2006.rdf

5 6 Pineapples, FT 6 21 2006.rdf

6 6 new FDA Raspberry 06 29 2006.rdf

7 6 Banana, PBNB-FT 6 21 2006.rdf

8 6 FLturf2applmaxDW_triadimefon.rdf

EPA Crop Food Name Def Res Adj.Factors RDL Comment

Code Grp (ppm) #1 #2 Pntr

\-\-\-\-\-\-\-- \-\-\--
\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--
\-\-\-\-\-\-\-\-\-- \-\-\-\-\-- \-\-\-\-\-- \-\-- \-\-\-\-\-\--

86010000 O Water, direct, all sources 0.100000 1.000 1.000 8

86020000 O Water, indirect, all sources 0.100000 1.000 1.000 8

**Attachment 10 Acute Aggregate (Water only) Residue Analysis**

U.S. Environmental Protection Agency Ver. 2.02

DEEM-FCID ACUTE Analysis for TRIADIMEFON (1994-98 data)

Residue file: AggregateWateronly_7242006.R98 Adjustment factor #2 used.

Analysis Date: 07-25-2006/09:45:07 Residue file dated:
07-25-2006/09:41:04/8

Daily totals for food and foodform consumption used.

MC iterations = 1000 MC list in residue file MC seed = 10

Run Comment: \"Triadimefon + Triadimenol \[drinking water only\] \"

===============================================================================

Summary calculations (per capita):

95th Percentile 99th Percentile 99.9th Percentile

Exposure % aRfD Exposure % aRfD Exposure % aRfD

\-\-\-\-\-\-\-\-\-- \-\-\-\-\-\-\-- \-\-\-\-\-\-\-\-\-- \-\-\-\-\-\-\--
\-\-\-\-\-\-\-\-\-- \-\-\-\-\-\-\--

U.S. Population:

0.000812 23.87 0.002064 60.70 0.005235 153.96

All infants:

0.002904 85.42 0.007494 220.43 0.017596 517.54

Children 1-2 yrs:

0.001235 36.31 0.003156 92.83 0.007657 225.20

Children 3-5 yrs:

0.001148 33.76 0.002896 85.17 0.006935 203.96

Children 6-12 yrs:

0.000789 23.21 0.001990 58.52 0.004794 141.01

Youth 13-19 yrs:

0.000602 17.69 0.001582 46.54 0.004005 117.80

Adults 20-49 yrs:

0.000763 22.43 0.001908 56.12 0.004574 134.54

Adults 50+ yrs:

0.000789 23.21 0.001857 54.62 0.003999 117.61

Females 13-49 yrs:

0.000764 22.47 0.001921 56.51 0.004562 134.18

**Attachment 11 Chronic Aggregate (Water only) Residue Input Data**

U.S. Environmental Protection Agency Ver. 2.00

DEEM-FCID Chronic analysis for TRIADIMEFON 1994-98 data

Residue file: C:\\Documents and
Settings\\spiper\\SPIPER\\triadimenol\\AggregateWateronly_7242006chronic.R98

Adjust. #2 used

Analysis Date 07-25-2006 Residue file dated: 07-25-2006/09:52:02/8

Reference dose (RfD) = 0.0034 mg/kg bw/day

Comment:Chronic: Triadimefon + Triadimenol \[drinking water only\]

\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--

Food Crop Residue Adj.Factors Comment

EPA Code Grp Food Name (ppm)

#1 #2

\-\-\-\-\-\-\-- \-\-\--
\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--
\-\-\-\-\-\-\-\-\-- \-\-\-\-\-- \-\-\-\-\-- \-\-\-\-\-\--

86010000 O Water, direct, all sources 0.019633 1.000 1.000

86020000 O Water, indirect, all sources 0.019633 1.000 1.000

**Attachment 12 Chronic Aggregate (Water only) Residue Analysis**

U.S. Environmental Protection Agency Ver. 2.00

DEEM-FCID Chronic analysis for TRIADIMEFON (1994-98 data)

Residue file name: C:\\Documents and
Settings\\spiper\\SPIPER\\triadimenol\\AggregateWateronly_7242006chronic.R98

Adjustment factor #2 used.

Analysis Date 07-25-2006/09:52:41 Residue file dated:
07-25-2006/09:52:02/8

Reference dose (RfD, Chronic) = .0034 mg/kg bw/day

COMMENT 1: Chronic: Triadimefon + Triadimenol \[drinking water only\]

===============================================================================

Total exposure by population subgroup

\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--

Total Exposure

\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--

Population mg/kg Percent of

Subgroup body wt/day Rfd

\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--
\-\-\-\-\-\-\-\-\-\-\-\-- \-\-\-\-\-\-\-\-\-\-\-\-\-\--

U.S. Population (total) 0.000414 12.2%

U.S. Population (spring season) 0.000410 12.1%

U.S. Population (summer season) 0.000445 13.1%

U.S. Population (autumn season) 0.000400 11.8%

U.S. Population (winter season) 0.000400 11.8%

Northeast region 0.000377 11.1%

Midwest region 0.000418 12.3%

Southern region 0.000393 11.6%

Western region 0.000474 13.9%

Hispanics 0.000470 13.8%

Non-hispanic whites 0.000404 11.9%

Non-hispanic blacks 0.000393 11.6%

Non-hisp/non-white/non-black 0.000507 14.9%

All infants (\< 1 year) 0.001357 39.9%

Nursing infants 0.000503 14.8%

Non-nursing infants 0.001681 49.4%

Children 1-6 yrs 0.000578 17.0%

Children 7-12 yrs 0.000376 11.1%

Females 13-19 (not preg or nursing) 0.000291 8.6%

Females 20+ (not preg or nursing) 0.000413 12.1%

Females 13-50 yrs 0.000400 11.8%

Females 13+ (preg/not nursing) 0.000402 11.8%

Females 13+ (nursing) 0.000573 16.9%

Males 13-19 yrs 0.000304 9.0%

Males 20+ yrs 0.000371 10.9%

Seniors 55+ 0.000406 11.9%

Children 1-2 yrs 0.000615 18.1%

Children 3-5 yrs 0.000575 16.9%

Children 6-12 yrs 0.000397 11.7%

Youth 13-19 yrs 0.000299 8.8%

Adults 20-49 yrs 0.000386 11.4%

Adults 50+ yrs 0.000406 12.0%

Females 13-49 yrs 0.000385 11.3%

\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--

**Attachment 13: Short-term Aggregate Calculations**

Short Term Aggregate Calculations: short-term aggregate for the
\"residential M/L/A WP hose-end azalea\" scenario which has an MOE of
1100 (dermal+inhalation) is calculated using the chronic dietary
aggregate (food + water) with an exposure number for the U.S. general
population = 0.000607 mg/kg/day or an MOE = 5600.  The resulting short
term aggregate has an MOE of 920. The \"residential M/L/A WP low-P
hand-wand GH ornamentals\" with a dermal+inhalation MOE of 1700 plus the
chronic food + water number noted above.  The resulting short term
aggregate has an MOE of 1300.

Short term aggregate (toddler) using post-application exposure to sod
turf scenarios: the MOE (combined) at a sod preharvest interval of 15
days was 1100; MOE was \<1000 at 14 days.  Calculation: using the 1100
MOE and the chronic dietary (food +water) exposure for \"Children 1-2
yrs\" which had an exposure number of 0.001108 mg/kg/day or an MOE of
3100.  This dietary assessment subgroup is the best match with toddlers
as well as being protective of other children\'s population subgroups
capable of \"toddling.\"  The resulting short term aggregate has an MOE
was 810.  

> The calculated number of days necessary to result in a short term
> aggregate has an MOE of ≥ 1000. On day 17, the combined MOE's for
> toddlers on turf at the rate of 2.7 lb a.i. /A rate is 1700.  When
> that is aggregated with the 3100 MOE, the aggregate is 1100.\
>  \
> The individual MOE's are: a) Hand-To-Mouth = 2500; b) Object-To-Mouth
> = 10,000; c) Soil = 31,000; Dermal = 11,000\
>  \
> Day 16 does not pass \-- it is 920 with the total aggregate.