**George Iliakis, Ph.D.**

Professor and Director

Experimental Radiation Oncology

Thomas Jefferson University Hospital, Philadelphia, PA

[EDUCATION]{.underline}

University of Athens, Athens, Greece: M. Sc. in Physics, 1975

University of Frankfurt, Main, West Germany: Ph. D. in Biophysics, 1978

[PROFESSIONAL EXPERIENCE]{.underline}

2001-present Vice President, Radiation Research Society, USA

1991-present Director, Division of Experimental Radiation Oncology,
Department of Radiation Therapy & Nuclear Medicine, Thomas Jefferson
University Hospital, Philadelphia, PA

1989-present Professor, Department of Radiation Therapy & Nuclear
Medicine, Thomas Jefferson University Hospital, Philadelphia, P A

1985-1989 Associate Professor, Department of Radiation Therapy & Nuclear
Medicine, Thomas Jefferson University Hospital, Philadelphia, PA

1985. Project Scientist in the Research Division, Cleveland Clinic
      Foundation

1978-1982 Research Associate at the \"Gesellschaft für Strahlen- und
Umweltforschung\" in Frankfurt/Main

1982-1983 Research Associate at the University of Frankfurt/Main

[REPRESENTATIVE PUBLICATIONS (Selected from a total of 121)]{.underline}

-   [Iliakis, G.]{.underline}, and Okayasu, R. Radiosensitivity
    throughout the cell cycle and repair of potentially lethal damage
    and DNA double-strand breaks in an X-ray-sensitive CHO mutant. Int.
    J Radiat. Biol. [57]{.underline}: 1195-1211, 1990.

-   [Iliakis, G.]{.underline}, Metzger, L., Denko, N., and Stamato, T.D.
    Detection of DNA double strand breaks in synchronous cultures of CHO
    cells by means of asymmetric field inversion gel electrophoresis.
    Int. J. Radiat. Biol. [59]{.underline}, 321-341, 1991.

-   [Iliakis, G.E.]{.underline}, Cicilioni, O. and Metzger, L.
    Measurement of DNA double strand breaks in CHO cells at various
    stages of the cell cycle using pulsed field gel electrophoresis:
    Calibration by means of 125I decay. Int. J. Radiat. Biol.
    [59]{.underline}, 343-357, 1991.

-   Metzger, L., and [Iliakis, G]{.underline}. Repair kinetics of DNA
    double strand breaks throughout the cell cycle measured by pulsed
    field gel electrophoresis. Int. J. Radiat. Biol. [59]{.underline},
    1325-1339, 1991.

-   [Iliakis, G.]{.underline} The role of DNA double strand breaks in
    ionizing radiation induced killing of eucaryotic cells. BioEssays.
    13, 641-648, 1991.

-   Wang, Ya., and [Iliakis, G.]{.underline} Prolonged inhibition by
    x-rays of DNA synthesis in cells obtained by transformation of
    primary rat embryo fibroblasts with the oncogenes H-RAS and v-MYC.
    Cancer Res. 52, 508-514, 1992.

-   Cheong, N., Wang, Y., Jackson, M., and [Iliakis, G.]{.underline}
    Radiation-sensitive IRS mutants rejoin DNA double strand breaks with
    efficiency similar to that of parental V-79 cells but show altered
    response to radiation induced G2-delay. Mutat. Res. 274:111-122,
    1992.

-   Muschel, R.J., Zhang, H.B., [Iliakis, G.]{.underline}, and McKenna,
    W.G. Effects of ionizing radiation on cyclin expression in HeLa
    Cells. Radiat. Res. 132:153-157, 1992.

-   Okayasu, R. and [Iliakis, G.]{.underline} Evidence that the product
    of the xrs gene is predominantly involved in the repair of a subset
    of radiation-induced interphase chromosome breaks rejoining with
    fast kinetics. Radiat. Res. 138: 34-43, 1993.

-   Cheng, X., Pantelias, G.E., Okayasu, R., Cheong, N. and [Iliakis,
    G.]{.underline} MPF activity of inducer mitotic cells may affect the
    radiation yield of interphase chromosome breaks in the premature
    chromosome condensation assay. Cancer Research, 53:5592-5596, 1993.

-   Okayasu, R., Varlotto, J., and [Iliakis, G.]{.underline} Hypertonic
    Treatment Does Not Affect The Radiation Yield Of Interphase
    Chromosome Breaks In DNA Double-Strand Break Repair Deficient xrs-5
    Cells. Radiat. Res. [135:]{.underline} 171-177, 1993.

-   Cheong, N., Wang, Y., and [Iliakis, G]{.underline}., Radioresistance
    induced in rat embryo cells by transfection with the oncogenes H-ras
    and v-myc is cell cycle dependent and maximal during S and G2. Int.
    J Radiat. Biol. [63:]{.underline} 623-629, 1993.

-   Wang, Y., Cheong, N., and [Iliakis, G.,]{.underline} Persistent
    inhibition of DNA synthesis in irradiated rat embryo fibroblasts
    expressing the oncogenes H-ras plus v-myc derives from inhibition of
    replicon initiation and is mitigated by staurosporine. Cancer Res.
    [53:]{.underline} 1213-1217, 1993.

-   Wang, X., and [Iliakis, G]{.underline}., Persistent inhibition of
    DNA synthesis after radiation exposure in four clones obtained from
    rat embryo fibroblasts by transfection with the oncogenes H-ras plus
    v-myc. Int. J Radiat. Biol. [64:]{.underline} 165-168, 1993.

-   Cheong, N., Xiaoming, W., Wang, Y., and [Iliakis, G]{.underline}.
    Loss of S-Phase dependent radioresistance in irs-1 cells exposed to
    x-rays. Mutat. Res. [314:]{.underline} 77-85, 1994.

-   Cheng, X. and [Iliakis, G.]{.underline}, Effect of ionizing
    radiation on the expression of chloramphenicol acetyltransferase
    gene under the control of commonly used constitutive or inducible
    promoters. Int. J. Radiat. Biol. 67: 261-267, 1995.

-   Wang, Y., Huq, M.S. Cheng, X., and [Iliakis, G.]{.underline},
    Regulation of DNA replication in irradiated cells by trans-acting
    factors. Radiat. Res., 142: 169-175, 1995.

-   Ganguly, T. and [Iliakis, G.]{.underline}, A cell-free assay using
    cytoplasmic cell extracts to study rejoining of radiation-induced
    DNA double strand breaks in human cell nuclei. Int. J. Radiat. Biol.
    68:447-457. 1995

-   Kinashi, Y., Okayasu, R., [Iliakis, G.E.]{.underline}, Nagasawa, H.
    and Little, J.B., Induction of DNA double strand breaks by
    restriction enzymes in x-ray sensitive mutant CHO cells (xrs-5)
    measured by pulse field gel electrophoresis. Radiat. Res.
    141:153-159, 1995.

-   Wang, Y., Huq, M.S. and [Iliakis, G]{.underline}. Evidence for
    activities inhibiting in trans initiation of DNA replication in
    extract prepared from irradiated cells. Radiat. Res. 145:408-418,
    1996.

-   Cheong, N., Okayasu, R., Shah, S., Ganguly, T., Mammen, and
    [Iliakis, G.]{.underline} In vitro rejoining of double strand breaks
    in cellular DNA by factors present in extracts of HeLa cells.
    Int. J. Radiat. Biol. [69:]{.underline} 665-677, 1996.

-   Cheong, N., and [Iliakis, G.,]{.underline} In vitro rejoining of
    double strand breaks induced in cellular DNA by bleomycin and
    restriction endonucleases. Int. J. Radiat. Biol. [71]{.underline}:
    365-375, 1997.

-   Wang, Y., Perrault, R., and Iliakis, G., Down-Regulation of DNA
    Replication in Extracts of Camptothecin-Treated Cells: Activation of
    an S-phase Checkpoint? Cancer Res. [57:]{.underline} 1654-1659,
    1997.

-   Iliakis, G. Cell cycle regulation in irradiated and nonirradiated
    cells. Seminars in Oncology, [24:]{.underline} 602-615, 1997.

-   Wang, Y., Perrault, R., and [Iliakis, G.,]{.underline} Replication
    Protein A as a Potential Regulator of DNA Replication in Cells
    Exposed to Hyperthermia. Radiation Res. [149:]{.underline} 284-293,
    1997.

-   Cheong, N., Perrault, A.R., and [Iliakis, G.]{.underline} In vitro
    rejoining of double strand breaks: A comparison of genomic-DNA with
    plasmid-DNA based assays. Int. J. Radiat. Biol.,
    [73]{.underline}:481-493, 1998.

-   Cheong, N., Perrault, R, Wang, H., Wachsberger, P., Mammen, P.,
    Jackson, I. and [Iliakis, G.]{.underline} DNA-PK-independent
    rejoining of DNA double strand breaks in human cell extracts in
    vitro. Int. J. Radiat. Biol. 75:67-81, 1999.

-   [Iliakis, G.]{.underline} and Cheong, N. In vitro rejoining of
    double strand breaks in genomic DNA. Methods in Molecular Biology.
    DNA Repair Protocols: Eukaryotic Systems. Vol. 113: 473-486,1999.

-   [Iliakis, G.]{.underline} Wang, Y. and Wang, H-Y. Analysis of
    inhibition of DNA replication in irradiated cells using the SV40
    based in vitro assay of DNA replication. Methods in Molecular
    Biology. DNA Repair Protocols: Eukaryotic Systems. Vol. 113:543-553,
    1999.

-   Wachsberger, P.R., Li, W-H., Guo, M., Chen, D., Cheong, N., Ling,
    C.C., and [Iliakis, G.]{.underline} Rejoining of DNA double strand
    breaks in Ku80-deficient mouse fibroblasts. Radiation Research,
    151:398-407, 1999.

-   Wachsberger, P.R., and [Iliakis, G.]{.underline} Hyperthermia does
    not affect rejoining of DNA double-strand breaks in a cell-free
    assay. Int. J. Radiat. Biol. 76:313-326-2000.

-   Wang, Y., Zhou, X.Y., Wang, H-Y. Huq, S., and [Iliakis,
    G.]{.underline} Roles of replication protein A and DNA-dependent
    protein kinase in the regulation of DNA replication following DNA
    damage. J Biol. Chem., 274:22060-22064, 1999.

-   DiBiase, S.J., Guan, J., Curran, Jr., W.J., and [Iliakis,
    G.]{.underline} Repair of DNA double-strand breaks and
    radiosensitivity to killing in an isogenic group of p53 mutant cell
    lines. Int. J. Radiat. Oncol. Biol. Phys. 45:743-751, 1999.

-   DiBiase, S.J., Zeng, Z-C., Chen, R., Hyslop, T., Curran, W.J., and
    [Iliakis, G.]{.underline} DNA-dependent protein kinase stimulates an
    independently active, non-homologous, end-joining apparatus. Cancer
    Research, 60:1245-1253, 2000.

-   Kurdoglu, B., Cheong, N., Guan, J., Corn, B.J., Curran, Jr., W.J.,
    and [Iliakis, G]{.underline}. Apoptosis as a predictor of
    paclitaxel-induced radiosensitization in human tumor cell lines.
    Clinical Cancer Res., 5:2580-2587, 1999.

-   Guan, J. DiBiase, S. and [Iliakis, G]{.underline}. The catalytic
    subunit DNA-dependent protein kinase (DNA-PKcs) facilitates recovery
    from radiation-induced inhibition of DNA replication. Nucleic Acids
    Research, 28:1183-1192, 2000.

-   Asaad, N.A., Zeng, Z-C., Guan, J., Thacker, J. and [Iliakis,
    G.]{.underline} Homologous recombination as a potential target for
    caffeine radiosensitization in mammalian cells: reduced caffeine
    radiosensitization in *XRCC2* and *XRCC3* mutants. Oncogene,
    19:5788-5800, 2000.

-   Wang, H., Zeng, Z-C., Bui, T-A., Sonoda, E., Takata, M., Takeda, S.,
    and [Iliakis, G.]{.underline} Efficient rejoining of
    radiation-induced DNA double-strand breaks in vertebrate cells
    deficient in genes of the *RAD52* epistasis group. Oncogene, In
    Press, 2001.

-   Wang, H-C., Zeng Z-C., Bui, T-A., DiBiase, S-.J., Qin. W., Xia, F.,
    Powell^,^ S.N., and [Iliakis, G.]{.underline} Nonhomologous
    end-joining of ionizing radiation-induced DNA double-stranded breaks
    in human tumor cells deficient in BRCA1 or BRCA2. Cancer Research,
    61:270-277, 2001.

-   Perrault, R., Cheong, N., Wang, H., Wang, H., and [Iliakis,
    G.]{.underline} RPA facilitates rejoining of DNA double strand
    breaks in an in vitro assay utilizing genomic DNA as substrate.
    Int. J. Radiat. Biol. In Press, 2001.

-   Cheong, N., Zeng, Z-C., Wang, Y. and [Iliakis, G.]{.underline}
    Evidence for factors modulating radiation-induced G2-delay:
    Potential application as radioprotectors. In Press. Physica Medica,
    Vol. XVII, Supplement 1, 2001.

-   Wang, H., Zeng, Z-C., Perrault, A.R., Cheng,X., Qin, W., and
    [Iliakis, G.]{.underline} Genetic evidence for the involvement of
    DNA ligase IV in the DNA-PK-dependent pathway of non-homologous
    endjoining in mammalian cells. Nucleic Acids Research, 29:
    1653-1660, 2001.

-   Wang, Y., Guan, J., Wang, H., Wang, Y., Leeper, D., and [Iliakis,
    G]{.underline}. Regulation Of DNA Replication After Heat Shock By
    RPA-Nucleolin Interactions. J. Biol. Chem. In Press, 276:000-000
    2001.

-   Andrews, D.W., Resnicoff, M., Flanders, A.E., Kenyon, L., Curtis,
    M., Merli, G. Baserga, R., Iliakis, G., and Aiken, R.D. Results of a
    pilot study involving the use of an antisense oligodeoxynucleotide
    directed against the insulin-like growth factor type I receptor in
    malignant astrocytomas. J Clinical Oncology, 19: 2189-2200, 2001.

-   Hu, B., Zhou, X-Y., Wang, X., Zeng, Z-C., [Iliakis, G.,]{.underline}
    and Wang, Y. The radioresistance to killing of A1-5 cells derives
    from activation of the Chk1 pathway. J. Biological Chemistry, 276:
    000-000, 2001.