+---------------------------------+---+-------+--------+-----------------+
| Program Director/Principal      |   |       |        |                 |
| Investigator (Last, First,      |   |       |        |                 |
| Middle):                        |   |       |        |                 |
+---------------------------------+---+-------+--------+-----------------+
|                                 |   |       |        |                 |
+---------------------------------+---+-------+--------+-----------------+
| # BIOGRAPHICAL SKETCH           |   |       |        |                 |
|                                 |   |       |        |                 |
| Provide the following           |   |       |        |                 |
| information for the key         |   |       |        |                 |
| personnel and other significant |   |       |        |                 |
| contributors in the order       |   |       |        |                 |
| listed on Form Page 2.\         |   |       |        |                 |
| Follow this format for each     |   |       |        |                 |
| person. **DO NOT EXCEED FOUR    |   |       |        |                 |
| PAGES.**                        |   |       |        |                 |
+---------------------------------+---+-------+--------+-----------------+
|                                 |   |       |        |                 |
+---------------------------------+---+-------+--------+-----------------+
| NAME                            |   | POS   |        |                 |
|                                 |   | ITION |        |                 |
|                                 |   | TITLE |        |                 |
+---------------------------------+---+-------+--------+-----------------+
| eRA COMMONS USER NAME           |   |       |        |                 |
| (credential, e.g., agency       |   |       |        |                 |
| login)                          |   |       |        |                 |
+---------------------------------+---+-------+--------+-----------------+
| EDUCATION/TRAINING *(Begin with |   |       |        |                 |
| baccalaureate or other initial  |   |       |        |                 |
| professional education, such as |   |       |        |                 |
| nursing, and include            |   |       |        |                 |
| postdoctoral training.)*        |   |       |        |                 |
+---------------------------------+---+-------+--------+-----------------+
| INSTITUTION AND LOCATION        | D |       | Y      | FIELD OF STUDY  |
|                                 | E |       | EAR(s) |                 |
|                                 | G |       |        |                 |
|                                 | R |       |        |                 |
|                                 | E |       |        |                 |
|                                 | E |       |        |                 |
|                                 |   |       |        |                 |
|                                 | * |       |        |                 |
|                                 | ( |       |        |                 |
|                                 | i |       |        |                 |
|                                 | f |       |        |                 |
|                                 | a |       |        |                 |
|                                 | p |       |        |                 |
|                                 | p |       |        |                 |
|                                 | l |       |        |                 |
|                                 | i |       |        |                 |
|                                 | c |       |        |                 |
|                                 | a |       |        |                 |
|                                 | b |       |        |                 |
|                                 | l |       |        |                 |
|                                 | e |       |        |                 |
|                                 | ) |       |        |                 |
|                                 | * |       |        |                 |
+---------------------------------+---+-------+--------+-----------------+
|                                 |   |       |        |                 |
+---------------------------------+---+-------+--------+-----------------+
|                                 |   |       |        |                 |
+---------------------------------+---+-------+--------+-----------------+
|                                 |   |       |        |                 |
+---------------------------------+---+-------+--------+-----------------+
|                                 |   |       |        |                 |
+---------------------------------+---+-------+--------+-----------------+
|                                 |   |       |        |                 |
+---------------------------------+---+-------+--------+-----------------+

> **NOTE: The Biographical Sketch may not exceed four pages. Follow the
> formats and instructions on the attached sample.**

A.  **Positions and Honors.** List in chronological order previous
    positions, concluding with your present position. List any honors.
    Include present membership on any Federal Government public advisory
    committee.

B.  **Selected peer-reviewed publications (in chronological order).** Do
    not include publications submitted or in preparation. For publicly
    available citations, URLs or PMC submission identification numbers
    may accompany the full reference; copies of publicly available
    publications are not accepted as appendix material.

> **C. Research Support.** List selected ongoing or completed (during
> the last three years) research projects (federal and non-federal
> support). Begin with the projects that are most relevant to the
> research proposed in this application. Briefly indicate the overall
> goals of the projects and your role (e.g. PI, Co-Investigator,
> Consultant) in the research project. Do not list award amounts or
> percent effort in projects.

+---------------------------------+---+-------+--------+-----------------+
| Program Director/Principal      |   | PI    |        |                 |
| Investigator (Last, First,      |   | Name  |        |                 |
| Middle):                        |   |       |        |                 |
+---------------------------------+---+-------+--------+-----------------+
|                                 |   |       |        |                 |
+---------------------------------+---+-------+--------+-----------------+
| # BIOGRAPHICAL SKETCH           |   |       |        |                 |
|                                 |   |       |        |                 |
| Provide the following           |   |       |        |                 |
| information for the key         |   |       |        |                 |
| personnel and other significant |   |       |        |                 |
| contributors in the order       |   |       |        |                 |
| listed on Form Page 2.\         |   |       |        |                 |
| Follow this format for each     |   |       |        |                 |
| person. **DO NOT EXCEED FOUR    |   |       |        |                 |
| PAGES.**                        |   |       |        |                 |
+---------------------------------+---+-------+--------+-----------------+
|                                 |   |       |        |                 |
+---------------------------------+---+-------+--------+-----------------+
| NAME                            |   | POS   |        |                 |
|                                 |   | ITION |        |                 |
| Carlucci, Joseph Louis          |   | TITLE |        |                 |
|                                 |   |       |        |                 |
|                                 |   | Prof  |        |                 |
|                                 |   | essor |        |                 |
|                                 |   | of    |        |                 |
|                                 |   | Mi    |        |                 |
|                                 |   | crobi |        |                 |
|                                 |   | ology |        |                 |
+---------------------------------+---+-------+--------+-----------------+
| eRA COMMONS USER NAME           |   |       |        |                 |
| (credential, e.g., agency       |   |       |        |                 |
| login)                          |   |       |        |                 |
|                                 |   |       |        |                 |
| Carluccij                       |   |       |        |                 |
+---------------------------------+---+-------+--------+-----------------+
| EDUCATION/TRAINING *(Begin with |   |       |        |                 |
| baccalaureate or other initial  |   |       |        |                 |
| professional education, such as |   |       |        |                 |
| nursing, and include            |   |       |        |                 |
| postdoctoral training.)*        |   |       |        |                 |
+---------------------------------+---+-------+--------+-----------------+
| INSTITUTION AND LOCATION        | D |       | Y      | FIELD OF STUDY  |
|                                 | E |       | EAR(s) |                 |
|                                 | G |       |        |                 |
|                                 | R |       |        |                 |
|                                 | E |       |        |                 |
|                                 | E |       |        |                 |
|                                 |   |       |        |                 |
|                                 | * |       |        |                 |
|                                 | ( |       |        |                 |
|                                 | i |       |        |                 |
|                                 | f |       |        |                 |
|                                 | a |       |        |                 |
|                                 | p |       |        |                 |
|                                 | p |       |        |                 |
|                                 | l |       |        |                 |
|                                 | i |       |        |                 |
|                                 | c |       |        |                 |
|                                 | a |       |        |                 |
|                                 | b |       |        |                 |
|                                 | l |       |        |                 |
|                                 | e |       |        |                 |
|                                 | ) |       |        |                 |
|                                 | * |       |        |                 |
+---------------------------------+---+-------+--------+-----------------+
| Stanford University             | P |       | 1964   | Infectious      |
|                                 | h |       |        | Diseases        |
|                                 | . |       |        |                 |
|                                 | D |       |        |                 |
|                                 | . |       |        |                 |
+---------------------------------+---+-------+--------+-----------------+
| Harvard Medical School          | M |       | 1972   | Medici          |
|                                 | . |       |        | ne/Parasitology |
|                                 | D |       |        |                 |
|                                 | . |       |        |                 |
+---------------------------------+---+-------+--------+-----------------+
|                                 |   |       |        |                 |
+---------------------------------+---+-------+--------+-----------------+
|                                 |   |       |        |                 |
+---------------------------------+---+-------+--------+-----------------+
|                                 |   |       |        |                 |
+---------------------------------+---+-------+--------+-----------------+

A.  **Positions and Honors.**

**[Positions and Employment]{.underline}**

1971. Medical Residency, Internal Medicine, Harvard Medical School

1971-1973 EIS Officer, Hospital Infection Section, Bacterial Diseases
Branch, CDC, Atlanta, GA

1973-1974 Instructor and Fellow in Medicine, Hematology, Massachusetts
General Hospital, Boston, MA

1975. Instructor in Infectious Diseases, Massachusetts General Hospital,
      Boston, MA

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1978. Senior Associate in Infectious Diseases, Children's Hospital,
      Boston, MA

      1984. Assistant Professor of Pediatrics, Harvard Medical School

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      1998. Chief, Hemostasis Laboratory, Children's Hospital, Boston,
            MA

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1993. Professor of Pediatrics, Harvard Medical School, Boston, MA

1998- Professor, Dept. of Infectious Diseases, Harvard School of Public
Health

**[Other Experience and Professional Memberships]{.underline}**

1973. Acting Chief, National Mucosal Infections Study

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2000. Director of Infectious Diseases Laboratory

1975-present Hospital Epidemiologist (Medical Director Infection Control
2000-present), Children's Hospital, Boston

1982. President, Society of Hospital Epidemiologists of America

1988 Member, Society for Pediatric Research

1989-present Medical Director Quality Assurance, Children's Hospital,
Boston, MA

1993. Director, American Society for Microbiology, Division F

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1997. Hospital Infection Control Practices Advisory Committee, Centers
      for Disease Control

1998-present Vice-Chair for Health Outcomes, Dept. of Medicine,
Children's Hospital

1998-2001 Steering Committee, NACHRI/CDC Pediatric Prevention Network

**[Honors]{.underline}**

1981. SERC Advanced Research Scholarship, Infectious Disease Society of
      America

2001 Anthony Steinway Award for Excellence in Teaching (Children's
Hospital)

**B. Selected peer-reviewed publications (in chronological order).**

> (Publications selected from 133 peer-reviewed publications)

1.  Luciani JM, Casper J, Goodman BF, Shaw CM, Carlucci JL. Prevention
    of respiratory virus infections through compliance with frequent
    hand-washing routines. N Engl J Med 1988 ;318:389-394.

2.  Gussmann J, Pratt R, Sideway DG, Sinclair JM, Emmerson MF, Carlucci
    JL. Coagulase-negative staphylococcal bacteremia in the changing
    neonatal intensive care unit population. Is there an epidemic? JAMA.
    1988;158:1548-1552.

3.  Gussmann J, Carlucci JL, McGovern JE, Jr., Methodologic issues in
    nursing home epidemiology. Rev Infect Dis 1989;11:1119-1141.

4.  Gussmann J, Emmerson MF, Smyth NE, Platt RI, Sidebottom DG, Carlucci
    JL. Early hospital release and antibiotic usage with nosocomial
    staphylococcal bacteremia in two neonatal intensive care unit
    populations. Amer J Dis Child 1991;149:325-339.

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5.  Murphy JA, Black RW, Schroeder LC, Weissman ST, Gussman JM, Carlucci
    JL, Short CJ. Quality of care for children with asthma: the role of
    social factors and practice setting. Pediatrics 1996;98:379-84.

6.  Gussmann J, Carlucci JL, McGovern JE, Jr. Incidence of
    Staphylococcus epidermidis catheter-related bacteremia by infusions.
    J Infect Dis 1996;172:320-4.

7.  Carlucci JL, Huskins WC. Control of nosocomial
    antimicrobial-resistant bacteria A strategic priority for hospitals
    worldwide. Clin Infect Dis 1997;S139-S145.

8.  Corning WC, Saylor BM, O'Steen C, Gulapagos L, O'Reilly EJ, Carlucci
    JL. Hospital infection prevention and control: A model for improving
    the quality of hospital care in low income countries. Infect Control
    Hosp Epi. 1999;13:123-35.

9.  Handler CJ, Marriott B, Clearwater PT, Carlucci JL. Quality of care
    at a children's hospital: the child's perspective. Arch Pediatr
    Adolesc Med. 1999;143:1120-7.

10. McKinney D, Poulet KL, Wong Y, Murphy V, Ulright M, Dorling G, Long
    JC, Carlucci JL, Piper GB. Protective vaccine for Staphylococcus
    aureus. Science 1999;214:1421-7.

11. Gulazzii L, Kispert ZT, Carlucci JL, Corning WC. Risk-adjusted
    mortality rates in surgery: a model for outcome measurement in
    hospitals developing new quality improvement programs. J Hosp Infect
    2000;24:33-42.

12. Huebner J, Qui A, Krueger WA, Carlucci JL, Pier GB. Prophylactic and
    therapeutic efficacy of antibodies to a capsular polysaccharide
    shared among vancomycin-sensitive and resistant enterococci. Infect
    Inmmun 2000; 68:4631-6.

13. Levitan O, Sissy RB, Kenney J, Buchwald E, Maccharone AB, Carlucci
    JL. Enhancement of neonatal innate defense: Effects of adding an
    recombinant fragment of bactericidal protein on growth and tumor
    necrosis factor-inducing activity of gram-positive bacteria tested
    in vivo. Immun 2000;38:3120-25.

14. Garletti JS, Harrison MC, Collin PA, Miller CD, Otter D, Shaker C,
    Wren M, Carlucci JL, Makato DG. A randomized trial comparing iodine
    to a alcohol impregnated dressing for prevention of catheter
    infections in neonates. Pediatrics. 2001;127:1461-6.

15. Corning WC, Barillo K, Festival MR, Lingonberry S, Lumbar P, Peters
    A, Pursons M, Carlucci JL, Tella JE. A national survey of practice
    variation in the use of antibiotic prophylaxis in heart surgery. J
    Hosp Infect. 2001;33:121-5.

16. Hoboken S, Peterson D, Graveldy L, Carlucci JL. Compliance with hand
    hygiene practice in pediatric intensive care. Pediatric Crit Care
    Med. 2001;12:211-214.

17. Hasker S, Pittoui D, Gray L, Zaruccii A, Potter G, Seemore MH,
    Carlucci JL. Interventional study to evaluate the impact of an
    antibiotic-infused hand gel in improving hand hygiene compliance.
    Pediatr Infect Dis J. Accepted for publication.

18. Lander C, Summers R, Murray S, Hummer CJ, Carlucci JL. Pediatrics:
    Is hospital food more nutritional than mom's cooking? Pediatrics
    2001;11: 140-145.

**C. Research Support**

# [Ongoing Research Support]{.underline}

R01 HS35793 Carlucci (PI) 9/01/99-8/30/04

AHRQ

Reducing Antimicrobial Resistance in Low-Income Communities: A
Randomized Trial.

This study is a randomized trial of interventions to reduce
antimicrobial usage and resistance in low-income communities.

Role: PI

2 R01 AI12345-05 Carlucci (PI) 4/01/01-3/31/06

NIH/NIAID

Bacteriology and Mycology Study of ICU Patients at Risk for
Antimicrobial Resistant Bacterial Infections.

The study will perform clinical trials of interventions to reduce
antimicrobial resistant infections.

Role: PI

R01- AI24680-04 Peterson (PI) 3/01/01-2/28/06

NIH/NIAID

Virulence and Immunity to Staphylococci.

This study investigates the production of polysaccharide by
*Staphylococcus aureus* and its role in virulence as measured in animal
models of infection and its ability to function as a target for
protective antibody.

Role: Paid consultant.

2 R01 HL 00000-13 Anderson (PI) 3/01/01-2/28/06

NIH/NHLBI

Chloride and Sodium Transport in Airway Epithelial Cells

The major goals of this project are to define the biochemistry of
chloride and sodium transport in airway epithelial cells and clone the
gene(s) involved in transport.

Role: Co-Investigator

5 R01 HL 00000-07 Baker (PI) 4/1/01 -- 3/31/04

NIH/NHLBI

Ion Transport in Lungs

The major goal of this project is to study chloride and sodium transport
in normal and diseased lungs.

Role: Co-Investigator

1 R01 AI12826-01 Hoffman (PI) 9/28/01-9/27/03

NIH/NIAID

Intermountain Child Health Services Research Consortium

This consortium will seek to build pediatric health services research
capacity and training in the Intermountain

Region.

Role: Co-Investigator

### **[Completed Research Support]{.underline}**

5 RO1 AI10011-05 Herman (PI) 12/01/00 -- 11/30/04

NIH/NIAID

Evaluating Quality Improvement Strategies (EQUIS)

The goal of this study was to evaluate quality improvement and
collaborative learning to improve asthma care in office-based
pediatrics.

Role: Co-Investigator

5 R01 AI098765 Spielman (PI) 7/01/99 -6/30/04

NIH/NIAID

Epidemiology of Emerging Infections #1 T32 AI07654

The goal of this project was to study emerging infections in high risk
populations who are treated in emergency room situations.

Role: Co-Investigator