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| **BIOGRAPHICAL SKETCH**         |   |       |         |               |
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| Provide the following           |   |       |         |               |
| information for the key         |   |       |         |               |
| personnel in the order listed   |   |       |         |               |
| for Form Page 2.                |   |       |         |               |
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| Follow the sample format on     |   |       |         |               |
| next page for each person. **DO |   |       |         |               |
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| NAME                            |   | POS   |         |               |
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| .                               |   | TITLE |         |               |
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| Michael C. Dean, Ph.D           |   |       |         |               |
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|                                 |   | Human |         |               |
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| EDUCATION/TRAINING *(Begin with |   |       |         |               |
| baccalaureate or other initial  |   |       |         |               |
| professional education, such as |   |       |         |               |
| nursing, and include            |   |       |         |               |
| postdoctoral training.)*        |   |       |         |               |
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| INSTITUTION AND LOCATION        | D |       | YEAR(s) | FIELD OF      |
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| Boston University, Boston, MA   | B |       | 1979    | Chemistry     |
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|                                 | A |       |         |               |
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| Boston University, Boston, MA   | P |       | 1984    | Biochemistry  |
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| Molecular Mechanisms of         | P |       | 1983-86 | Molecular     |
| Carcinogenesis\                 | o |       |         | Bio           |
| Laboratory, LBI-Basic Research  | s |       |         | logy/Genetics |
| Program,\                       | t |       |         |               |
| NCI-Frederick Cancer Res. Fac., | d |       |         |               |
| Frederick, MD                   | o |       |         |               |
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A.  **Positions and Honors.**

**[Positions and Employment]{.underline}**

1986-1991: Scientist I, Human Genetics Analysis Laboratory, Biochemical
Carcinogenesis and Development Program, Program Resources, Inc.,
NCI-FCRF, Frederick, Maryland.

1991-1993: Research Chemist, Human Genetics Section, Laboratory of Viral
Carcinogenesis, National Cancer Institute, NCI-FCRDC, Frederick, MD.

1993-date: Sr. Scientist, Chief, Human Genetics Section, Laboratory of
Genomic Diversity, National Cancer Institute, NCI-FCRDC, Frederick, MD.

**[Honors, Awards]{.underline}**

1998 Cornelius P. Rhoads Memorial Award

1998 NIH Directors Award

2005 ISI Highly Cited Scientist in Molecular Biology and Genetics

**B. Selected publications.**

Campisi, J., Gray, H.E., Pardee, A.B., Dean, M., and Sonenshein, G.E.:
Cell-cycle control of c-[myc]{.underline} but not c-[ras]{.underline}
expression is lost following chemical transformation. [Cell]{.underline}
36: 241-247, 1984.

White, R., Woodward, S., Leppert, M., O\'Connell, P., Hoff, M., Herbst,
J., Lalouel, J.-M., Dean, M., and Vande Woude, G.F.: A closely linked
genetic marker for cystic fibrosis. [Nature]{.underline} 318: 382-384,
1985.

Rommens, J.M., Iannuzzi, M.C., Kerem, B.S., Drumm, M.L., Melmer, G.,
Dean, M., Rozmahel, R., Cole L.J., Kennedy, D., Hidaka, N., Zsiga, M.,
Buchwald, M., Riordan, J.R., Tsui, L.C., and Collins, F.S.:
Identification of the cystic fibrosis gene: Chromosome walking and
jumping. [Science]{.underline} 245: 1059-1065, 1989

White, M.B., Amos, J., Hsu, J.M., Gerrard, B., Finn, P., and Dean, M.: A
frameshift mutation in the cystic fibrosis gene. [Nature]{.underline}
344: 665-667, 1990

Dean, M., White, M.B., Amos, J., Gerrard, B., Stewart, C., Khaw, K.-T.,
and Leppert, M.: Multiple mutations in highly conserved residues are
found in mildly affected cystic fibrosis patients. [Cell]{.underline}
61: 863-870, 1990

**[Publications]{.underline}** (continued):

Latif, F., Tory, K., Gnarra, J., Yao, M., Duh, F.-M., Orcot, M.L.,
Stackhouse, T., Kuzmin, I., Modi, W., Geil, L., Schmidt, L., Zhou, F.,
Li, H., Wei, M. H., Chan, F., Glenn, G., Choyke, P., Walther, M. M.,
Weng, Y., Duan, D.-S., Dean, M., Glavac, D., Richards, F. M., Crossey,
P. A., Ferguson-Smith, M. A., Le Pasilier, D., Chumakov, I., Cohen, D.,
Chinault, C. A., Maher, E. R., Linehan, W. M., Zbar, B., Lerman, M.:
Identification of the von Hippel-Lindau disease tumor suppressor gene.
[Science]{.underline} 260:1317-1320, 1993

Hahn, H., Wicking, C., Zaphiropoulos, P.G., Gailani, M.R., Shanley, S.,
Chidambaram, A., Vorechovsky, I., Holmberg, E., Unden, A.B., Gillies,
S., Negus, S., Smyth, I., Pressman, C., Leffell, D.J., Gerrard, B.,
Goldstein, A., Dean, M., Toftgard, R., Chenevix-Trench, G., Wainwright
B., Bale, A.: Mutations of the human homologue of Drosophila *patched*
in the nevoid basal cell carcinoma syndrome. [Cell]{.underline}
80:841-851, 1996

Dean, M., Carrington, M., Winkler, C., Huttley, G.A., Smith, M. W.,
Allikmets, R., Vlahov, D., Goedert, J., Vittinghoff, E., Buchbinder, S.,
Kaslow, R., Gomperts, E., and Stephen J. O\'Brien: Genetic Restriction
of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the
CKR5 Structural Gene. [Science]{.underline} 273:1856-1863, 1996

Allikmets, R., Singh, N., Sun, H., Shroyer, N.F., Hutchinson, A.,
Chidambaram, A., Gerrard, B., Baird, L., Stauffer, D., Peiffer, A.,
Rattner, A., Smallwood, P., Li, Y., Anderson, K.L., Lewis, R.A.,
Nathans, J., Leppert, M., Dean M., Lupski, J.R.: A photoreceptor
cell-specific ATP-binding transporter gene (*ABCR*) is mutated in
recessive Stargardt macular dystrophy. [Nature Genetics]{.underline}
15:236-246, 1997

Allikmets, R., Shroyer, N. F., Singh, N., Seddon, J.M., Lewis, R.A.,
Bernstein, P., Peiffer, A., Zabriskie, N., Li, Y., Hutchinson, A., Dean,
M., Lupski, J.R., Leppert, M.: Mutation of the Stargardt Disease Gene
(*ABCR*) in Age-Related Macular Degeneration. [Science]{.underline}
277:1805-1807, 1997

Smith, M. W., Dean, M., Carrington, M., Winkler, C., Huttley, G.A.,
Lomb, D.A., Goedert, J.J., O=Brien, T.R., Jacobson, L.P., Kaslow, R.,
Buchbinder, S., Vittinghoff, E., Vlahov, D., Hoots, K., Hilgartner,
M.W., Hemophilia Growth and Development Study, Multicenter AIDS Cohort
Study, San Francisco City Cohort, ALIVE Study, and Stephen J. O\'Brien:
Contrasting Genetic Influence of *CCR2* and *CCR5* Variants on HIV-1
Infection and Disease Progression. [Science]{.underline} 277: 959-965,
1997

Allikmets, R, Schriml, L.M. Hutchinson, A., Romano-Spica, V., and Dean,
M.: A human placenta-specific ATP-binding cassette gene (*ABCP*) on
chromosome 4q22 that is involved in multidrug resistance. [Cancer
Res.]{.underline} 58: 5337-5339, 1998

Martin, M.P., Dean, M., Smith, M.W., Winkler, C., Gerrard, B., Michael,
N.L., Lee, B., Doms, R.W., Margolick, J., Buchbinder, S., Goedert, J.J.,
O'Brien, T.R., Hilgartner, M.W., Hoots, K., Vlahov, D., O'Brien, S.J.
and Carrington, M.: Genetic acceleration of AIDS progression by a
promoter variant of *CCR5*. [Science]{.underline} 282: 1907-1911, 1998

Dean, M.: Cancer as a complex developmental disorder-Nineteenth
Cornelius P. Rhoads Memorial Award Lecture. [Cancer Res.]{.underline}
58: 5633-5636, 1998

Miyake, K., Mickley, L., Litman, T., Zhan, Z., Robey, R., Cristensen,
B., Brangi, F., Greenberger, L., Dean, M., Fojo, T., and Bates, S.:
Molecular cloning of cDNAs which are highly overexpressed in
mitoxantrone-resistant cells: Demonstration of homology to ABC transport
genes. [Cancer Res.]{.underline} 59: 8-13, 1999.

Lee, M.H., Lu, K., Hazard, S., Yu, H, Shulenin, S., Hidaka, H., Kojima,
H., Allikmets, R., Sakuma, N., Pegoraro, R., Srivastava, A.K., Salen,
G., Dean, M., and Patel. S.B.: Identification of a gene, *ABCG5*,
important in the regulation of dietary cholesterol. [Nat.
Genet.]{.underline} 27:79-83, 2001.

Dean, M., Rzhetsky, A., and Allikmets, R.: The human ATP-binding
cassette (ABC) transporter superfamily. [Genome Research]{.underline}.
11:1156-1166, 2001.

Egan, M.F., Kojima, M., Callicott, J.H., Goldberg, T.E., Kolachana,
B.S., Bertolino, A., Gold, B., Goldman, D., Dean, M., Lu, B., and
Weinberger, D.R.: BDNF Val66Met polymorphism affects vesicular packaging
and human hippocampal function. [Cell]{.underline} 112:257-269, 2003.

Shulenin, S., Nogee, L.M., Annilo, T., Wert, S.E., Whitsett, J.A., and
Dean, M. The ABCA3 gene is frequently mutated in human newborns with
fatal surfactant deficiency. [N.Eng.J.Med.]{.underline} 350:1296-1303,
2004.

Gold, B., Kalush, F., Bergeron, J., Scott, K., Mitra, N., Wilson, K.,
Ellis, N., Huang, H., Chen, M., Lippert R., Halldorsson, B.V.,
Woodworth, B., White, T., Clark, A.G., Parl, F.F., Broder, S., Dean, M.,
and Offit, K.: Estrogen Receptor Genotypes and Haplotypes Associated
with Breast Cancer Risk. [Cancer Res]{.underline}. 64:8891-8900, 2004.

Hageman, G.S., Anderson, D.H., Johnson, L.V., Hancox, L.S., Taiber,
A.J., Hardisty, L.I., Hageman, J.L., Stockman, H.A., Borchardt, J.D.,
Gehrs, K.M., Smith, R. J., Silvestri, G., Russell, S.R., Klaver, C.C.,
Barbazetto, I., Chang, S., Yannuzzi, L., Barile, G., Merriam, J.C.,
Smith, R.T., Olsh, A.K., Bergeron, J., Zernant, J., Merriam, JE., Gold,
B., Dean, M., and Allikmets, R.: A Common Haplotype in the Complement
Regulatory Gene, Factor H (HF1/CFH), Predisposes Individuals to
Age-related Macular Degeneration[. Proc. Natl. Acad. Sci.]{.underline}
102:7227-7232, 2005.

Gold, B., Merriam, J.E., Zernant, J., Hancox, L.S., Taiber, A.J., Gehrs,
K., Cramer, K., Neel, J., Bergeron, J., Barile, G.R., Smith, R.T., the
AMD Genetics Clinical Study Group, Hageman, G.S., Dean, M., and
Allikmets, R.: Variation in the Factor B (BF) and Complement Component 2
(C2) genes in the MHC Class III Locus is Associated with Age-related
Macular Degeneration. [Nat. Genet.]{.underline} 38:458-462, 2006.

Si, Z., Vandegraaff, N., O'hUigin, Song, B., Yuan, W., Xu, C., Perron,
M., Li, X., Marasco, W.A., Engelman, A., Dean, M., and Sodroski, J.:
Identification of a Novel Cytoplasmic TRIM Protein in Cows that
Restricts Retroviral Infection. [Proc. Natl. Acad. Sci.]{.underline}
103:7454-7459, 2006.

**C. Research Support**

# [Ongoing Research Support]{.underline}

ZOl BC 05652-09 LGD 10/91 - ongoing 50%

NIH \$322,064

Identification of Single Nucleotide Polymorphisms in Cancer-Related
Genes

Principal Investigator: Michael Dean

The major goals of this project are to identify common variants in genes
likely to play a role in cancer and to

type these variants in cancer cohorts.

ZOl BC 05725-07 LGD 10/93 - ongoing 50%

NIH \$393,190

ABC Transporters in Human Disease and Drug Resistance

Principal Investigator: Michael Dean

The major goals of this project are to characterize genes from the human
and mouse ABC family and study their role in disease and drug
resistance.