**NIH CENTERS FOR AIDS RESEARCH**

**P30 NONCOMPETING CONTINUATION (Type 5) APPLICATIONS**

Supplemental Guidance for Applicants using PHS 2590 Form

**I. Introduction**

These guidelines provide supplementary information regarding preparation
of the P30 noncompeting continuation (Type 5) application for the
Centers for AIDS Research program to be used in conjunction with the PHS
2590 Form, (Rev. 11/07)
<http://grants.nih.gov/grants/funding/2590/2590.htm>. The suggested
format for the application is designed to illuminate the special
features of P30 CFAR grants and provide the most useful information
about the CFAR program.

Narratives and progress reports provided in the type 5 applications
constitute a major source of information used by NIH Program Officials
to report on accomplishments of individual Centers, discuss the unique
value of the CFAR/Core Support Grant program and justify continuation of
the program to NIH Institutes, AIDS researchers, the Congress, and
ultimately, to the public. For these reasons, it is of paramount
importance that the application includes the most salient information on
scientific progress with particular attention to the special
contributions and achievements made possible by the Center and the P30
CFAR grant **that could not have been accomplished through individual
research grants alone.**

Principal Investigators are encouraged to submit thorough but concise
reports, to use summary charts and tables whenever possible, and to
reference materials and information submitted in previous reports and
applications rather than to include them again. Reports should be
limited to updating the activities and research progress since the last
reporting period. Page limitations suggested below are intended to be
upper limits.

**II. Contents of Progress Report Summary** (PHS 2590 Form, Rev 11/07,
Form Page 5)

This section is the primary scientific report of the CFAR; it should
**include only new information since the last reporting period,** and
should incorporate the following information:

**A.** **Director\'s Overview** (Suggested page limit: 10 pages)

The Director\'s Overview should consist of a summary, which broadly
discusses the most important scientific achievements supported by the
CFAR, significant changes and future plans of the center. Wherever
possible, organize and highlight the information thematically according
to the areas of interest of each NIH Institute. The suggested format for
the Director's Overview is as follows:

1.  [Brief Introduction]{.underline}

> Provide a brief description of the CFAR, its major areas of scientific
> emphasis, and other major features of the center.

2.  [Ongoing Activities and New Developments]{.underline}.

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a.  Please address how the CFAR identified research gaps or
    opportunities, evaluated ongoing programs, or implemented change in
    these areas. Describe the important ongoing activities, new ideas
    and developments, collaborations with other Centers and/or
    investigators in other academic institutions.

b.  Emphasize activities or events that have contributed to, or are
    likely to contribute to, improving interdisciplinary coordination
    and collaboration and the overall synergy of the centers research
    activities.

c.  Describe any changes that could be instrumental in the continuing
    development and strengthening of the Center including:

    -   the role and visibility of the CFAR within the parent
        institution

    -   types or degree of institutional commitment, including
        recruitment and specifically the role of the CFAR, space, funds,
        etc.

    -   overall research space, individual core space, and availability
        of specialized shared facilities.

> 3**.** [NIH Programs and Areas of Interest to the co-funding and
> participating NIH Institutes and Centers (ICs) which include: FIC,
> NCI, NCCAM, NHLBI, NIAID, NICHD, NIDA, and NIMH.]{.underline}
>
> Please include a brief section describing how the CFAR provided
> support or played a pivotal role in programs, grants, and research
> areas of interest to the NIH ICs listed above. This is an important
> part of the progress report as it is of great interest to the NIH ICs.
> This information is also critical in providing reasons for which to
> maintain support of the CFAR program. Added value

4.  [Major Research Results and Scientific Accomplishments]{.underline}

> This section should provide an integrated report on the overall
> scientific achievements of the CFAR over the reporting period. This
> report should only highlight recent and significant accomplishments
> and research supported, in whole or in part, by CFAR.
>
> The detailed reports on individual projects should be included in the
> appropriate individual core sections.

5.  [Scientific Programs (if applicable)]{.underline}

> Provide a summary report of the scientific programs describing new
> collaborations that have been established. Please also describe the
> projects that are being funded within the scientific programs and
> provide a summary report for these as well. Include information on the
> funding source and outcomes, if available, for projects arising from
> the scientific program.

6.  [Future Plans]{.underline}

> Discuss future plans for further development and strengthening of the
> center, including any plans for stimulating innovative, collaborative
> research approaches or developing translational research (e.g., basic
> to clinical and clinical to basic).

B.  **CFAR Spreadsheets and Tables**

    Please include this information at the end of the Director's
    Overview.

    1.  [Members and Funding Base Excel spreadsheet]{.underline}

> Please include NIH AIDS funding comprising the funded research base
> and a separate spreadsheet on research funding from other sources.
>
> The most recent excel spread sheet for your CFAR may be requested from
> the NIH program officer. Please indicate under 'Members' column the
> nature of each investigator's participation in the CFAR. A key table
> can be made to list the various levels of participation (e.g., CD =
> Core Director, CU = Core User, S = attends CFAR sponsored seminars,
> etc.). Some investigators will probably have several letters in the
> column.
>
> Note: the most current Funded Research Base (FRB) database is
> generally not available until April. Therefore, if your progress
> report is due prior to April, please use the FRB that was provided in
> the previous fiscal year.

2.  [Existing Core Facilities table (if applicable) - This table can be
    found on]{.underline}
    <http://www.niaid.nih.gov/research/cfar/cfarpa.htm>.

3.  The tables on Previous Recipients of Developmental Award Recipients
    and Core Utilization should be included with the applicable Cores.

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C.  **Cores** -- There are several administrative details that NIH needs
    to know. Explain any significant changes for each core, or new cores
    that have been established.

> 1\. **[All Cores]{.underline}** (Suggested page limit: 6-10 pages,
> each core)
>
> Maintain the core identifiers (Administrative, Core A, Core B,
> Developmental, etc.) and core title in the same format as in the
> original competing application. New cores should NOT utilize a
> previously deleted core identifier or core title.
>
> For each core, provide the following information:

a\. Operational Information

Include the following information as applicable:

-   Key personnel changes

-   Changes to policies and procedures

-   New and/or deleted services -- explain why added/deleted

-   Future plans.

    b.  Overview of Core services (e.g. equipment, training, services,
        databases, specimen repositories, expertise/advice for research
        activities etc.)

> 2\. **[Administrative Core]{.underline}**
>
> In addition to the information requested under All Cores, provide the
> following information:

-   Organizational chart. Provide an organizational chart showing the
    relative position of the CFAR in the parent institution. Provide a
    separate organizational chart of the CFAR itself. Highlight any
    changes from the previous reporting period.

-   Activities of internal and external advisory committees. Include
    agenda and copy of any committee reports.

-   Report any changes in Policies and Procedures for approval by NIH.
    Include any changes pertaining to prioritization of usage of shared
    resources.

-   Report on annual Strategic Planning Process

-   Briefly describe any training, outreach, education, Core activities,
    etc. that the CFAR supported.

-   Additional CFAR-supported activities (Please only address activities
    that are not addressed elsewhere in the progress report.)

> Examples could include but are not limited to the following:

-   industry collaborations

-   development of minority and women scientists in AIDS research

-   AIDS research communications to non-scientists

-   approach to problems in enrollment and retention of women and
    minority groups in AIDS clinical trials

-   international collaborations

-   other activities that meet the AIDS research needs of applicant
    institutions

> 3\. **[Developmental Core]{.underline}**
>
> In addition to the information requested under All Cores, provide the
> following information:

-   Details on awards made during current reporting period

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-   Number, title, and investigator names of all applications received

-   Category of awards made (e.g., investigators new to HIV/AIDS
    research, feasibility studies, emerging research opportunities, and
    HIV/AIDS research activities of newly recruited faculty.

-   Please specify if any of the awards were funded with non-CFAR funds.

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-   Abstract for applications funded

-   Progress on pilot awards and CFAR supplements that are ongoing (if
    applicable)

-   Final report on pilot awards and CFAR supplements completed during
    the reporting period.

    -   Include how the pilot award or supplement led to new scientific
        direction, if applicable.

    -   Report all publications or external funding received.

-   Recruitment as specifically applicable to the Core

    -   Include names of investigators recruited

    -   Role of CFAR in recruitment

    -   Pilot awards issued as part of recruitment package, if
        applicable

-   Training/mentoring provided

    -   Explain the nature of training/mentoring provided

    -   Name of trainees/mentees and their mentors

    -   Evaluation/outcome of past mentoring relationships

-   Include table on Previous Recipients of Developmental Awards for the
    past 5 years (See table for more details.)

-   Please provide copies of IRB and IACUC approval letters for all
    ongoing and new projects involving human and animal subjects.

-   For studies with an international component, please include copies
    of applicable IRB or ethics or Ministry of Health approvals for the
    foreign country involved.

-   Include a targeted/planned enrollment table for each study involving
    human subjects. Note: if the pilot study is nested under an ongoing
    NIH study for which this information is already being collected,
    please simply indicate that on the form with the parent grant's
    title or number. These tables can also be included as part of the
    appendices.

    4\. **[Basic and Clinical Cores]{.underline}**

> In addition to the information requested under All Cores, provide the
> following information:

-   If applicable, include information on program income generated.

    -   Provide total dollar amount generated by program income

    -   Describe how the freed CFAR Core budget and program income
        generated will be used or redirected (e.g., additional funds for
        pilot awards, new assays/services for the Core, new Cores
        established, etc.)

-   Scientific Accomplishments

    -   Provide a summary report of the most significant scientific
        research completed through Core support for the reporting
        period, noting the significance of accomplishments.

    -   List several exemplary projects that have been supported through
        the core and their value, importance and/or significance to the
        advancement of AIDS and AIDS-related research.

    -   Please also indicate how the Core provided support for these
        projects.

-   Describe whether the number of core users has increased, decreased,
    or stayed the same since the last progress report. Please explain.

-   Describe what the Core has done to increase utilization of the
    Core's services.

-   Include Core Utilization Table - indicate the approximate percent
    usage for each major user, until at least 80 percent of the core
    capacity is accounted for. Then list the total usage for non-major
    users under \"others\". The Core Utilization Table can be found on
    <http://www.niaid.nih.gov/research/cfar/cfarpa.htm>.

D.  **Publications**

Provide a [list]{.underline} of AIDS and AIDS-related publications
supported by the CFAR from the last report submission. List the titles
and complete references of publications in alphabetical order by first
author. Highlight those publications that illustrate inter- or
intra-programmatic collaborations (e.g. use asterisk or other
designation). Provide one copy of the 10 best publications not
previously submitted as an attachment to the Type 5 progress report.
Please also provide PMCID numbers, if available.

**[SUBMITTING YOUR PROGRESS REPORT]{.underline}**

Progress reports are required to continue support of a PHS grant and for
NIH grantees, must be **submitted two months** before the beginning date
of the next budget period using the PHS 2590.

All NIH progress reports must be submitted **to the centralized mailing
address:**

Division of Extramural Activities Support

OER National Institutes of health

6705 Rockledge Drive, Room 2207, MSC 7987

Bethesda, MD 20892-7987 (for regular or US Postal Service Express mail)
Bethesda, MD 20817 (for other courier/express mail delivery only)

Additional information on the PHS 2590 can be found on
http://grants.nih.gov/grants/funding/2590/phs2590.pdf.

For grantee institutions and PIs registered in the NIH eRA Commons, the
progress report due information is available in the Commons Status
system. Commons-registered institutions and PIs also have access to
pre-populated face pages via Status. For more information on the NIH
Commons, see: <http://commons.era.nih.gov/commons/index.jsp>.