DSSTox Field Definition File:

Carcinogenic Potency Database Summary Tables -- All Species (CPDBAS)

*(last updated 20 November 2008)*

**Description:** Information in this file is intended to document the
DSSTox SDF (Structure Data Format) file created for the Carcinogenic
Potency Database Summary Tables -- All Species (CPDBAS), obtained from
the CPDB Source website: <http://potency.berkeley.edu/>. CPDBAS_v5
contains consolidated DSSTox CPDB files for rat/mouse, hamster, dog, and
non-human primates and includes additional fields, modified fields, and
URL links to chemical data pages on the CPDB website (see current CPDBAS
SDF Download Page and CPDBAS_LogFile for more details). For further
explanation of Source-specific toxicity fields, a user is encouraged to
consult the CPDB website, listed references, and documentation.
Additional information is provided on the DSSTox CPDBAS SDF Download
Page <http://www.epa.gov/ncct/dsstox/sdf_cpdbas.html>. All modifications
to the original fields contained in the CPDB Summary Tables are
documented in the ***Comments*** section of the table below.

Description of ***DSSTox Standard Chemical Fields*** can be found in the
Central Field Definition Table located at:

<http://www.epa.gov/ncct/dsstox/CentralFieldDef.html>

The first section of the Table below lists the ***DSSTox Standard
Toxicity Fields*** employed for this database, followed by the ***CPDBAS
Source-Specific Fields*** containing the toxicity information particular
to CPDBAS. The ***Field Type*** indicates the type of the field, such as
numeric, integer, defined text, memo, etc. All ***Units*** and
***Descriptions*** are extracted from Source reference materials unless
otherwise noted. ***Allowable Entries*** lists allowed field entries
occurring in CPDBAS, separated by slashes for exclusive entries (i.e.,
cannot occur with another entry) and semicolons or spaces for
non-exclusive entries (i.e., can occur with other values). These are
defined and explained in the ***Description*** section.

The **Note_CPDBAS** field (previously **ToxicityNote**) is used for
several purposes in CPDBAS. This field documents any additions of new
chemical record or data modifications from CPDB(RM,HA,DG,PR)\_v1 to
CPDBAS_v2a and subsequent versions of CPDBAS. In addition, any
information specific only to the chemical information in CPDBAS (i.e.,
not pertaining to any other data file containing this same chemical
record) that was previously provided in the **ChemicalNote** field (v3)
has been moved to the **Note_CPDBAS** field. New or modified activity
summary fields added to CPDBAS_v5b correspond to activities represented
in PubChem and include **ActivityOutcome_CPDBAS\_,,,** fields for
Mutagenicity, SingleCellCall, MultiCellCall, Rat, Mouse, Hamster, and
Dog_Primates, and **ActivityScore_CPDBAS\_\...** fields
\[Log(1/TD50mmol) mapped onto 0-100 integer range\] for Rat, Mouse,
Hamster, and Dog_Primates. Since two species listed in the Source CPDB
Summary Tables (Bush Baby and Tree Shrew) have data for only a single
chemical record each, and the chemical record in each case is also
listed in the CPDB Rat Mouse table, data for these species are provided
only in the **TD50_Dog_Primates_Note** field of the corresponding
chemical record.

**Source Website:** The complete, updated CPDB, from which the Summary
Tables and CPDBAS are derived, is available in several formats at:
<http://potency.berkeley.edu/>

**Source Contact:** Please contact Lois Swirsky Gold for questions
pertaining to the content of the CPDB Summary Tables; email:
<cpdb@potency.berkeley.edu> Please contact [DSSTox
Support](http://www.epa.gov/ncct/dsstox/dsscontact.html) for questions
or comments pertaining to the DSSTox CPDBAS SDF file.

**Main Citations:** Publications reporting use of the DSSTox SDF file
for the CPDB Summary Tables are asked to list the full DSSTox file name,
including date stamp, and to cite as primary reference the following
citations:

Gold, L.S., T.H. Slone, B.N. Ames, N.B. Manley, G.B. Garfinkel, and L.
Rohrbach (1997) Chapter 1: Carcinogenic Potency Database. In: Gold,
L.S., and E. Zeiger, Eds. Handbook of Carcinogenic Potency and
Genotoxicity Databases. Boca Raton, FL: CRC Press, pp. 1-605.
[http://potency.berkeley.edu/text/methods.html](http://potency.berkeley.edu/text/methods.html )

Gold, L.S., N.B. Manley, T.H. Slone, and J.M. Ward (2001) Compendium of
chemical carcinogens by target organ: Results of chronic bioassays in
rats, mice, hamsters, dogs and monkeys. Toxicol. Pathol. 29: 639-652.
http://potency.berkeley.edu/text/ToxicolPathol.pdf

Gold, L. S., Manley, N. B., Slone, T. H., Rohrbach, L., and Garfinkel,
G.B. Supplement to the Carcinogenic Potency Database (CPDB): Results of
Animal Bioassays Published in the General Literature through 1997 and by
the National Toxicology Program in 1997 and 1998. Toxicol. Sci. 85:
747-800 (2005).
[http://potency.berkeley.edu/pdfs/ToxSciPlot.pdf](http://potency.berkeley.edu/pdfs/ToxSciPlot.pdf )

Carcinogenicty Potency Data Base (2008)
[http://potency.berkeley.edu/](http://potency.berkeley.edu/ )

Summary Table of Chemicals in the Carcinogenic Potency Database: Results
for Positivity, Potency (TD50), and Target Sites:
[http://potency.berkeley.edu/chemicalsummary.html](http://potency.berkeley.edu/chemicalsummary.html )

See also, a full listing of Data Plots (from which the CPDB Summary
Table was derived) and CPDB publications at:

[http://potency.berkeley.edu/listofpubs.topic.html#plots](http://potency.berkeley.edu/listofpubs.topic.html%23plots)

[http://potency.berkeley.edu/listofpubs.topic.html](http://potency.berkeley.edu/listofpubs.topic.html )

**SDF Usage Notes:**

Each DSSTox SDF file contains a single **STRUCTURE** field. For each
chemical record, the **STRUCTURE** field entry directly corresponds to
the content of the **STRUCTURE\_\...** fields. The **STRUCTURE_Shown**
field documents the relationship between what is displayed in the
**STRUCTURE** field and the actual tested chemical substance, i.e.
**TestSubstance\_\...** fields, with the latter corresponding directly
to the toxicity data field entries. Commercial chemical relational
database (CRD) applications may automatically insert one or more
structure identifier fields upon import or export of an SDF file (e.g.,
Formula, FW or Mol_ID), fields that may augment or duplicate one or more
of the DSSTox Standard Chemical Fields. Users are cautioned that fields
containing null values in the first record of the SDF will be reordered
upon import into most applications; for this reason, the word "blank"
has been inserted into null fields in Record 1 of DSSTox SDF files and
can be deleted after SDF import. Users are additionally cautioned that
some fields (**STRUCTURE_SMILES** and **STRUCTURE_InChI**, in
particular) may exceed the 200 character limit specified in the MDL
CTFiles SDF standard (see
<http://www.epa.gov/ncct/dsstox/MoreonSDF.html>), and that some CRD
applications may insert a line break or truncate these fields upon SDF
import or export. Finally, CRD application-specific molecular header
information in the SDF file is deleted in the final DSSTox SDF files;
users running CRD applications requiring a unique molecule header upon
import of the SDF can specify either **DSSTox_RID** or the
**DSSTox_FileID** be used. Upon SDF import, **DSSTox_CID** can be used
to identify and manage chemical structure duplicates and
**DSSTox_Generic_SID** can be used to identify common Test Substances
across and within DSSTox files (similar to CASRN-substance, but
available for all DSSTox substances and further distinguishes among
different purity/grade substances).

*As an MS Word document, the following table is best viewed onscreen
using either Normal or Web Layout View in Landscape page orientation.*

+-------+-----+---+-------+---+---------------------+---------------------+
| ***   | **  | * | **    | # |                     | ## *Comments*       |
| Field | *Fi | * | *Allo |   |                     |                     |
| Na    | eld | * | wable | * |                     |                     |
| me*** | T   | U | Entri | D |                     |                     |
|       | ype | n | es*** | e |                     |                     |
|       | *** | i |       | s |                     |                     |
|       |     | t |       | c |                     |                     |
|       |     | s |       | r |                     |                     |
|       |     | * |       | i |                     |                     |
|       |     | * |       | p |                     |                     |
|       |     | * |       | t |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | * |                     |                     |
+-------+-----+---+-------+---+---------------------+---------------------+
|       |     |   |       | # |                     |                     |
|       |     |   |       | # |                     |                     |
|       |     |   |       | # |                     |                     |
|       |     |   |       | # |                     |                     |
|       |     |   |       | # |                     |                     |
|       |     |   |       |   |                     |                     |
|       |     |   |       | D |                     |                     |
|       |     |   |       | S |                     |                     |
|       |     |   |       | S |                     |                     |
|       |     |   |       | T |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | x |                     |                     |
|       |     |   |       |   |                     |                     |
|       |     |   |       | S |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       |   |                     |                     |
|       |     |   |       | T |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | x |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | y |                     |                     |
|       |     |   |       |   |                     |                     |
|       |     |   |       | F |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | s |                     |                     |
+-------+-----+---+-------+---+---------------------+---------------------+
| **St  | d   |   | Carci | F |                     | Field names and     |
| udy** | efi |   | nogen | i |                     | content are being   |
|       | ned |   | icity | e |                     | coordinated with    |
| **T   | t   |   |       | l |                     | the public ToxML    |
| ype** | ext |   |       | d |                     | standardization     |
|       |     |   |       | i |                     | effort.             |
| *(no  |     |   |       | s |                     |                     |
| spa   |     |   |       | u |                     |                     |
| ces)* |     |   |       | s |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | b |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | b |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | , |                     |                     |
|       |     |   |       | g |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | y |                     |                     |
|       |     |   |       | w |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | y |                     |                     |
|       |     |   |       | , |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | g |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | - |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | b |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | g |                     |                     |
|       |     |   |       | . |                     |                     |
|       |     |   |       | F |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | y |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | y |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | x |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | y |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | y |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | w |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | b |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | . |                     |                     |
+-------+-----+---+-------+---+---------------------+---------------------+
| # End | d   |   | TD50, | F |                     | Field names and     |
| point | efi |   | Tumor | i |                     | content are being   |
|       | ned |   | T     | e |                     | coordinated with    |
|       | t   |   | arget | l |                     | the public ToxML    |
|       | ext |   | Sites | d |                     | standardization     |
|       |     |   |       | i |                     | effort.             |
|       |     |   |       | s |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | b |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | b |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | , |                     |                     |
|       |     |   |       | g |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | l |                     |                     |
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|       |     |   |       | w |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | y |                     |                     |
|       |     |   |       | , |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | g |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | - |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | b |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | g |                     |                     |
|       |     |   |       | . |                     |                     |
|       |     |   |       | F |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | y |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | y |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | x |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | y |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | w |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | b |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | . |                     |                     |
+-------+-----+---+-------+---+---------------------+---------------------+
| *     | d   |   | rat,  | F |                     | Field names and     |
| *Spec | efi |   | m     | i |                     | content are being   |
| ies** | ned |   | ouse, | e |                     | coordinated with    |
|       | t   |   | ham   | l |                     | the public ToxML    |
|       | ext |   | ster, | d |                     | standardization     |
|       |     |   | dog,  | i |                     | effort.             |
|       |     |   | rh    | s |                     |                     |
|       |     |   | esus, | u |                     |                     |
|       |     |   | c     | s |                     |                     |
|       |     |   | ynomo | e |                     |                     |
|       |     |   | lgus, | d |                     |                     |
|       |     |   | tree  | t |                     |                     |
|       |     |   | s     | o |                     |                     |
|       |     |   | hrew, | l |                     |                     |
|       |     |   | bush  | a |                     |                     |
|       |     |   | baby  | b |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | b |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | g |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | - |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | b |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | g |                     |                     |
|       |     |   |       | . |                     |                     |
|       |     |   |       | F |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | y |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | ( |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | ) |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | x |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | y |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | y |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | . |                     |                     |
+-------+-----+---+-------+---+---------------------+---------------------+
|       |     |   |       | # |                     |                     |
|       |     |   |       | # |                     |                     |
|       |     |   |       | # |                     |                     |
|       |     |   |       | # |                     |                     |
|       |     |   |       | # |                     |                     |
|       |     |   |       |   |                     |                     |
|       |     |   |       | C |                     |                     |
|       |     |   |       | P |                     |                     |
|       |     |   |       | D |                     |                     |
|       |     |   |       | B |                     |                     |
|       |     |   |       | A |                     |                     |
|       |     |   |       | S |                     |                     |
|       |     |   |       |   |                     |                     |
|       |     |   |       | S |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | - |                     |                     |
|       |     |   |       | S |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       |   |                     |                     |
|       |     |   |       | F |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | s |                     |                     |
+-------+-----+---+-------+---+---------------------+---------------------+
| **Ac  | d   |   | ac    | A |                     | This field is       |
| tivit | efi |   | tive/ | c |                     | titled "Salmonella" |
| yOutc | ned |   |       | h |                     | in the original     |
| ome\_ | t   |   | inac  | e |                     | CPDB Summary        |
| \     | ext |   | tive/ | m |                     | Tables; symbol      |
| _CPDB |     |   |       | i |                     | entries appearing   |
| AS\_\ |     |   | *b    | c |                     | in this field were  |
| Muta  |     |   | lank* | a |                     | converted to the    |
| genic |     |   |       | l |                     | following DSSTox    |
| ity** |     |   |       | i |                     | text equivalents:   |
|       |     |   |       | s |                     |                     |
|       |     |   |       | c |                     | > "+" = active      |
|       |     |   |       | l |                     | >                   |
|       |     |   |       | a |                     | > "-" = inactive    |
|       |     |   |       | s |                     | >                   |
|       |     |   |       | s |                     | > "." = *blank* (no |
|       |     |   |       | i |                     | > evaluation)       |
|       |     |   |       | f |                     |                     |
|       |     |   |       | i |                     | Activity field      |
|       |     |   |       | e |                     | deposited in        |
|       |     |   |       | d |                     | PubChem.            |
|       |     |   |       | w |                     |                     |
|       |     |   |       | i |                     | *Field renamed and  |
|       |     |   |       | t |                     | modified in v5b;    |
|       |     |   |       | h |                     | previously*         |
|       |     |   |       | i |                     | **Mutag             |
|       |     |   |       | n |                     | enicity_SAL_CPDB.** |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | C |                     |                     |
|       |     |   |       | P |                     |                     |
|       |     |   |       | D |                     |                     |
|       |     |   |       | B |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | g |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | , |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | . |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | . |                     |                     |
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|       |     |   |       | t |                     |                     |
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|       |     |   |       | n |                     |                     |
|       |     |   |       | g |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | b |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | v |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | . |                     |                     |
+-------+-----+---+-------+---+---------------------+---------------------+
| **TD5 | n   | m | #/    | T |                     | These fields appear |
| 0_Rat | ume | g |       | D |                     | under the column    |
| _mg** | ric | / | *b    | 5 |                     | headings "Harmonic  |
|       |     | k | lank* | 0 |                     | mean of TD50        |
| **    |     | g |       | i |                     | (mg/kg/day)" in the |
| TD50_ |     | - |       | s |                     | original CPDB       |
| Mouse |     | b |       | a |                     | Summary Tables by   |
| _mg** |     | o |       | s |                     | Species.            |
|       |     | d |       | t |                     |                     |
| **T   |     | y |       | a |                     | All footnotes and   |
| D50_H |     | w |       | n |                     | text entries from   |
| amste |     | t |       | d |                     | the original CPDB   |
| r\_** |     | / |       | a |                     | Summary Tables have |
|       |     | \ |       | r |                     | been expanded and   |
| *     |     | d |       | d |                     | moved to the        |
| *mg** |     | a |       | i |                     | corresponding       |
|       |     | y |       | z |                     | *                   |
| **TD5 |     |   |       | e |                     | *TD50\_\...\_Note** |
| 0_Dog |     |   |       | d |                     | field -- see below. |
| _mg** |     |   |       | q |                     |                     |
|       |     |   |       | u |                     | In the CPDB Summary |
| **T   |     |   |       | a |                     | Table for Non-Human |
| D50_R |     |   |       | n |                     | Primates, TD50      |
| hesus |     |   |       | t |                     | results were        |
| _mg** |     |   |       | i |                     | reported for only a |
|       |     |   |       | t |                     | single chemical in  |
| **    |     |   |       | a |                     | the case of either  |
| TD50_ |     |   |       | t |                     | the Tree Shrew and  |
| Cynom |     |   |       | i |                     | Bush Baby; in each  |
| olgus |     |   |       | v |                     | case, for a         |
| _mg** |     |   |       | e |                     | chemical already    |
|       |     |   |       | m |                     | present in another  |
| *(no  |     |   |       | e |                     | species CPDB        |
| spa   |     |   |       | a |                     | Summary Table. The  |
| ces)* |     |   |       | s |                     | single data result  |
|       |     |   |       | u |                     | in each case is     |
|       |     |   |       | r |                     | listed in the       |
|       |     |   |       | e |                     | **TD50_             |
|       |     |   |       | o |                     | Dog_Primates_Note** |
|       |     |   |       | f |                     | field with a        |
|       |     |   |       | c |                     | corresponding       |
|       |     |   |       | a |                     | species entry in    |
|       |     |   |       | r |                     | the **Species**     |
|       |     |   |       | c |                     | field, i.e.         |
|       |     |   |       | i |                     | separate            |
|       |     |   |       | n |                     | **TD50\_\...** and  |
|       |     |   |       | o |                     | **                  |
|       |     |   |       | g |                     | TargetSites\_\...** |
|       |     |   |       | e |                     | fields are not      |
|       |     |   |       | n |                     | included for these  |
|       |     |   |       | i |                     | two species in      |
|       |     |   |       | c |                     | CPDBAS.             |
|       |     |   |       | p |                     |                     |
|       |     |   |       | o |                     | *Converted to pure  |
|       |     |   |       | t |                     | numeric field in    |
|       |     |   |       | e |                     | v4a; footnotes      |
|       |     |   |       | n |                     | moved to*           |
|       |     |   |       | c |                     | **TD50              |
|       |     |   |       | y |                     | \_*species*\_Note** |
|       |     |   |       | ( |                     | *fields.*           |
|       |     |   |       | a |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | g |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | L |                     |                     |
|       |     |   |       | D |                     |                     |
|       |     |   |       | 5 |                     |                     |
|       |     |   |       | 0 |                     |                     |
|       |     |   |       | ) |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | C |                     |                     |
|       |     |   |       | P |                     |                     |
|       |     |   |       | D |                     |                     |
|       |     |   |       | B |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | / |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | x |                     |                     |
|       |     |   |       | / |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | / |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | y |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | x |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | . |                     |                     |
|       |     |   |       |   |                     |                     |
|       |     |   |       | T |                     |                     |
|       |     |   |       | D |                     |                     |
|       |     |   |       | 5 |                     |                     |
|       |     |   |       | 0 |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | : |                     |                     |
|       |     |   |       | " |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | - |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | g |                     |                     |
|       |     |   |       | / |                     |                     |
|       |     |   |       | k |                     |                     |
|       |     |   |       | g |                     |                     |
|       |     |   |       | b |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | y |                     |                     |
|       |     |   |       | w |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | / |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | y |                     |                     |
|       |     |   |       | w |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | , |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | y |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | , |                     |                     |
|       |     |   |       | w |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | v |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | b |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | b |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | y |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | g |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | g |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | " |                     |                     |
|       |     |   |       | \ |                     |                     |
|       |     |   |       | [ |                     |                     |
|       |     |   |       | 4 |                     |                     |
|       |     |   |       | - |                     |                     |
|       |     |   |       | 6 |                     |                     |
|       |     |   |       | \ |                     |                     |
|       |     |   |       | ] |                     |                     |
|       |     |   |       | . |                     |                     |
|       |     |   |       | I |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | C |                     |                     |
|       |     |   |       | P |                     |                     |
|       |     |   |       | D |                     |                     |
|       |     |   |       | B |                     |                     |
|       |     |   |       | S |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | y |                     |                     |
|       |     |   |       | T |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | b |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | , |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | T |                     |                     |
|       |     |   |       | D |                     |                     |
|       |     |   |       | 5 |                     |                     |
|       |     |   |       | 0 |                     |                     |
|       |     |   |       | ( |                     |                     |
|       |     |   |       | # |                     |                     |
|       |     |   |       | ) |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | w |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | v |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | v |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | g |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | y |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | t |                     |                     |
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|       |     |   |       | a |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | x |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | . |                     |                     |
|       |     |   |       | I |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | r |                     |                     |
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|       |     |   |       | i |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | n |                     |                     |
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|       |     |   |       | y |                     |                     |
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|       |     |   |       | p |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | t |                     |                     |
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|       |     |   |       | t |                     |                     |
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|       |     |   |       | s |                     |                     |
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|       |     |   |       | e |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | , |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | T |                     |                     |
|       |     |   |       | D |                     |                     |
|       |     |   |       | 5 |                     |                     |
|       |     |   |       | 0 |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | . |                     |                     |
|       |     |   |       | I |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
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|       |     |   |       | x |                     |                     |
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|       |     |   |       | m |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | v |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | , |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | T |                     |                     |
|       |     |   |       | D |                     |                     |
|       |     |   |       | 5 |                     |                     |
|       |     |   |       | 0 |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | s |                     |                     |
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|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | n |                     |                     |
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|       |     |   |       | f |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | m |                     |                     |
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|       |     |   |       | o |                     |                     |
|       |     |   |       | t |                     |                     |
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|       |     |   |       | D |                     |                     |
|       |     |   |       | 5 |                     |                     |
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|       |     |   |       | m |                     |                     |
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|       |     |   |       | a |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | p |                     |                     |
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|       |     |   |       | s |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | t |                     |                     |
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|       |     |   |       | v |                     |                     |
|       |     |   |       | e |                     |                     |
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|       |     |   |       | x |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | r |                     |                     |
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|       |     |   |       | m |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | i |                     |                     |
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|       |     |   |       | n |                     |                     |
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|       |     |   |       | s |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | r |                     |                     |
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|       |     |   |       | b |                     |                     |
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|       |     |   |       | p |                     |                     |
|       |     |   |       | : |                     |                     |
|       |     |   |       | / |                     |                     |
|       |     |   |       | / |                     |                     |
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|       |     |   |       | 3 |                     |                     |
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|       |     |   |       | 7 |                     |                     |
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|       |     |   |       | 9 |                     |                     |
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|       |     |   |       | D |                     |                     |
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|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | * |                     |                     |
|       |     |   |       | * |                     |                     |
|       |     |   |       | T |                     |                     |
|       |     |   |       | D |                     |                     |
|       |     |   |       | 5 |                     |                     |
|       |     |   |       | 0 |                     |                     |
|       |     |   |       | \ |                     |                     |
|       |     |   |       | _ |                     |                     |
|       |     |   |       | \ |                     |                     |
|       |     |   |       | . |                     |                     |
|       |     |   |       | . |                     |                     |
|       |     |   |       | . |                     |                     |
|       |     |   |       | \ |                     |                     |
|       |     |   |       | _ |                     |                     |
|       |     |   |       | N |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | * |                     |                     |
|       |     |   |       | * |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | y |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | g |                     |                     |
|       |     |   |       | S |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | ( |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | b |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | w |                     |                     |
|       |     |   |       | ) |                     |                     |
|       |     |   |       | . |                     |                     |
|       |     |   |       |   |                     |                     |
|       |     |   |       | * |                     |                     |
|       |     |   |       | " |                     |                     |
|       |     |   |       | b |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | k |                     |                     |
|       |     |   |       | " |                     |                     |
|       |     |   |       | * |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | y |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | T |                     |                     |
|       |     |   |       | D |                     |                     |
|       |     |   |       | 5 |                     |                     |
|       |     |   |       | 0 |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | - |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | x |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | g |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | y |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | w |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | : |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | x |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | C |                     |                     |
|       |     |   |       | P |                     |                     |
|       |     |   |       | D |                     |                     |
|       |     |   |       | B |                     |                     |
|       |     |   |       | , |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | v |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | . |                     |                     |
+-------+-----+---+-------+---+---------------------+---------------------+
| **    | n   | m | #/    | * |                     | See comments for    |
| TD50_ | ume | m |       | * |                     | **TD50\_\...\_mg**. |
| Rat_m | ric | o | *b    | T |                     |                     |
| mol** |     | l | lank* | D |                     |                     |
|       |     | / |       | 5 |                     |                     |
| **TD5 |     | k |       | 0 |                     |                     |
| 0_Mou |     | g |       | _ |                     |                     |
| se\_\ |     | - |       | R |                     |                     |
| m     |     | b |       | a |                     |                     |
| mol** |     | o |       | t |                     |                     |
|       |     | d |       | _ |                     |                     |
| **    |     | y |       | m |                     |                     |
| TD50_ |     | w |       | m |                     |                     |
| Hamst |     | t |       | o |                     |                     |
| er\_\ |     | / |       | l |                     |                     |
| m     |     | d |       | * |                     |                     |
| mol** |     | a |       | * |                     |                     |
|       |     | y |       | = |                     |                     |
| *(no  |     |   |       |   |                     |                     |
| spa   |     |   |       | * |                     |                     |
| ces)* |     |   |       | * |                     |                     |
|       |     |   |       | T |                     |                     |
|       |     |   |       | D |                     |                     |
|       |     |   |       | 5 |                     |                     |
|       |     |   |       | 0 |                     |                     |
|       |     |   |       | _ |                     |                     |
|       |     |   |       | R |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | _ |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | g |                     |                     |
|       |     |   |       | * |                     |                     |
|       |     |   |       | * |                     |                     |
|       |     |   |       | / |                     |                     |
|       |     |   |       | * |                     |                     |
|       |     |   |       | * |                     |                     |
|       |     |   |       | S |                     |                     |
|       |     |   |       | T |                     |                     |
|       |     |   |       | R |                     |                     |
|       |     |   |       | U |                     |                     |
|       |     |   |       | C |                     |                     |
|       |     |   |       | T |                     |                     |
|       |     |   |       | U |                     |                     |
|       |     |   |       | R |                     |                     |
|       |     |   |       | E |                     |                     |
|       |     |   |       | _ |                     |                     |
|       |     |   |       | M |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | W |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | g |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | * |                     |                     |
|       |     |   |       | * |                     |                     |
|       |     |   |       |   |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | . |                     |                     |
|       |     |   |       |   |                     |                     |
|       |     |   |       | S |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | * |                     |                     |
|       |     |   |       | * |                     |                     |
|       |     |   |       | T |                     |                     |
|       |     |   |       | D |                     |                     |
|       |     |   |       | 5 |                     |                     |
|       |     |   |       | 0 |                     |                     |
|       |     |   |       | _ |                     |                     |
|       |     |   |       | R |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | _ |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | g |                     |                     |
|       |     |   |       | * |                     |                     |
|       |     |   |       | * |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | . |                     |                     |
|       |     |   |       | T |                     |                     |
|       |     |   |       | D |                     |                     |
|       |     |   |       | 5 |                     |                     |
|       |     |   |       | 0 |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | / |                     |                     |
|       |     |   |       | k |                     |                     |
|       |     |   |       | g |                     |                     |
|       |     |   |       | / |                     |                     |
|       |     |   |       | b |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | y |                     |                     |
|       |     |   |       | w |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | g |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | / |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | y |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | v |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | 3 |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | ( |                     |                     |
|       |     |   |       | R |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | , |                     |                     |
|       |     |   |       | M |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | , |                     |                     |
|       |     |   |       | H |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | ) |                     |                     |
|       |     |   |       | . |                     |                     |
|       |     |   |       |   |                     |                     |
|       |     |   |       | S |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | g |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | v |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | q |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | k |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | w |                     |                     |
|       |     |   |       | l |                     |                     |
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|       |     |   |       | f |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
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|       |     |   |       | t |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | u |                     |                     |
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|       |     |   |       | a |                     |                     |
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|       |     |   |       | d |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | o |                     |                     |
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|       |     |   |       | e |                     |                     |
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|       |     |   |       | e |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | g |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | , |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | v |                     |                     |
|       |     |   |       | a |                     |                     |
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|       |     |   |       | s |                     |                     |
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|       |     |   |       | d |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | y |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | w |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | r |                     |                     |
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|       |     |   |       | a |                     |                     |
|       |     |   |       | * |                     |                     |
|       |     |   |       | * |                     |                     |
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|       |     |   |       | T |                     |                     |
|       |     |   |       | R |                     |                     |
|       |     |   |       | U |                     |                     |
|       |     |   |       | C |                     |                     |
|       |     |   |       | T |                     |                     |
|       |     |   |       | U |                     |                     |
|       |     |   |       | R |                     |                     |
|       |     |   |       | E |                     |                     |
|       |     |   |       | * |                     |                     |
|       |     |   |       | * |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | y |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | v |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | * |                     |                     |
|       |     |   |       | * |                     |                     |
|       |     |   |       | T |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | S |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | b |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | _ |                     |                     |
|       |     |   |       | D |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | * |                     |                     |
|       |     |   |       | * |                     |                     |
|       |     |   |       | = |                     |                     |
|       |     |   |       |   |                     |                     |
|       |     |   |       | > |                     |                     |
|       |     |   |       |   |                     |                     |
|       |     |   |       | " |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | g |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | > |                     |                     |
|       |     |   |       |   |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | > |                     |                     |
|       |     |   |       |   |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | " |                     |                     |
|       |     |   |       | ; |                     |                     |
|       |     |   |       | > |                     |                     |
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|       |     |   |       |   |                     |                     |
|       |     |   |       | " |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | x |                     |                     |
|       |     |   |       | t |                     |                     |
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|       |     |   |       | > |                     |                     |
|       |     |   |       |   |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | > |                     |                     |
|       |     |   |       |   |                     |                     |
|       |     |   |       | * |                     |                     |
|       |     |   |       | * |                     |                     |
|       |     |   |       | S |                     |                     |
|       |     |   |       | T |                     |                     |
|       |     |   |       | R |                     |                     |
|       |     |   |       | U |                     |                     |
|       |     |   |       | C |                     |                     |
|       |     |   |       | T |                     |                     |
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|       |     |   |       | R |                     |                     |
|       |     |   |       | E |                     |                     |
|       |     |   |       | _ |                     |                     |
|       |     |   |       | S |                     |                     |
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|       |     |   |       | w |                     |                     |
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|       |     |   |       | * |                     |                     |
|       |     |   |       | * |                     |                     |
|       |     |   |       | > |                     |                     |
|       |     |   |       |   |                     |                     |
|       |     |   |       | = |                     |                     |
|       |     |   |       | > |                     |                     |
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|       |     |   |       | " |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | v |                     |                     |
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|       |     |   |       | n |                     |                     |
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|       |     |   |       | r |                     |                     |
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|       |     |   |       | w |                     |                     |
|       |     |   |       | h |                     |                     |
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|       |     |   |       | m |                     |                     |
|       |     |   |       | g |                     |                     |
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|       |     |   |       | m |                     |                     |
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|       |     |   |       | e |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | > |                     |                     |
|       |     |   |       |   |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | v |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | > |                     |                     |
|       |     |   |       |   |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | > |                     |                     |
|       |     |   |       |   |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | > |                     |                     |
|       |     |   |       |   |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | > |                     |                     |
|       |     |   |       |   |                     |                     |
|       |     |   |       | w |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | g |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       |   |                     |                     |
|       |     |   |       | * |                     |                     |
|       |     |   |       | * |                     |                     |
|       |     |   |       | T |                     |                     |
|       |     |   |       | D |                     |                     |
|       |     |   |       | 5 |                     |                     |
|       |     |   |       | 0 |                     |                     |
|       |     |   |       | \ |                     |                     |
|       |     |   |       | _ |                     |                     |
|       |     |   |       | . |                     |                     |
|       |     |   |       | . |                     |                     |
|       |     |   |       | . |                     |                     |
|       |     |   |       | \ |                     |                     |
|       |     |   |       | _ |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | * |                     |                     |
|       |     |   |       | * |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | S |                     |                     |
|       |     |   |       | A |                     |                     |
|       |     |   |       | R |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | g |                     |                     |
|       |     |   |       | . |                     |                     |
|       |     |   |       |   |                     |                     |
|       |     |   |       | C |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | g |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | T |                     |                     |
|       |     |   |       | D |                     |                     |
|       |     |   |       | 5 |                     |                     |
|       |     |   |       | 0 |                     |                     |
|       |     |   |       | ( |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | g |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | f |                     |                     |
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|       |     |   |       | t |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | g |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | C |                     |                     |
|       |     |   |       | P |                     |                     |
|       |     |   |       | D |                     |                     |
|       |     |   |       | B |                     |                     |
|       |     |   |       | S |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | y |                     |                     |
|       |     |   |       | T |                     |                     |
|       |     |   |       | a |                     |                     |
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|       |     |   |       | ) |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | r |                     |                     |
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|       |     |   |       | v |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | * |                     |                     |
|       |     |   |       | * |                     |                     |
|       |     |   |       | T |                     |                     |
|       |     |   |       | D |                     |                     |
|       |     |   |       | 5 |                     |                     |
|       |     |   |       | 0 |                     |                     |
|       |     |   |       | \ |                     |                     |
|       |     |   |       | _ |                     |                     |
|       |     |   |       | \ |                     |                     |
|       |     |   |       | . |                     |                     |
|       |     |   |       | . |                     |                     |
|       |     |   |       | . |                     |                     |
|       |     |   |       | \ |                     |                     |
|       |     |   |       | _ |                     |                     |
|       |     |   |       | N |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | t |                     |                     |
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|       |     |   |       | * |                     |                     |
|       |     |   |       | * |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | y |                     |                     |
|       |     |   |       | f |                     |                     |
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|       |     |   |       | r |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | g |                     |                     |
|       |     |   |       | S |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | ( |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | b |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | w |                     |                     |
|       |     |   |       | ) |                     |                     |
|       |     |   |       | . |                     |                     |
|       |     |   |       |   |                     |                     |
|       |     |   |       | " |                     |                     |
|       |     |   |       | * |                     |                     |
|       |     |   |       | b |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | k |                     |                     |
|       |     |   |       | * |                     |                     |
|       |     |   |       | " |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | u |                     |                     |
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|       |     |   |       | l |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | y |                     |                     |
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|       |     |   |       | n |                     |                     |
|       |     |   |       | d |                     |                     |
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|       |     |   |       | c |                     |                     |
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|       |     |   |       | t |                     |                     |
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|       |     |   |       | n |                     |                     |
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|       |     |   |       | b |                     |                     |
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|       |     |   |       | f |                     |                     |
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|       |     |   |       | r |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | h |                     |                     |
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|       |     |   |       | c |                     |                     |
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|       |     |   |       | P |                     |                     |
|       |     |   |       | D |                     |                     |
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|       |     |   |       | b |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | b |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | g |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | x |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | v |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | g |                     |                     |
|       |     |   |       | d |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | f |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | M |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | u |                     |                     |
|       |     |   |       | l |                     |                     |
|       |     |   |       | a |                     |                     |
|       |     |   |       | r |                     |                     |
|       |     |   |       | W |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | i |                     |                     |
|       |     |   |       | g |                     |                     |
|       |     |   |       | h |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | c |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | m |                     |                     |
|       |     |   |       | p |                     |                     |
|       |     |   |       | o |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | e |                     |                     |
|       |     |   |       | n |                     |                     |
|       |     |   |       | t |                     |                     |
|       |     |   |       | s |                     |                     |
|       |     |   |       | . |                     |                     |
+-------+-----+---+-------+---+---------------------+---------------------+
| #     | m   |   | pos   |   | If a numerical      | These comments      |
| # TD5 | emo |   | itive |   | value of the TD50   | replace the         |
| 0_Rat |     |   | test  |   | is listed for a     | following footnote  |
| _Note |     |   | re    |   | given Species, it   | indices annotating  |
|       |     |   | sults |   | may be accompanied  | the TD50 result in  |
| ##    |     |   | only  |   | by one or more of   | the original Source |
| TD50_ |     |   | by    |   | the notes in this   | CPDB Summary        |
| Mouse |     |   | intra |   | field.              | Tables:             |
| _Note |     |   | perit |   |                     |                     |
|       |     |   | oneal |   | If there were no    | > i =               |
| ##    |     |   | or    |   | positive            | > Intraperitoneal   |
|  TD50 |     |   | i     |   | experiments in a    | > or intravenous    |
| _Hams |     |   | ntrav |   | species but the     | > injection are the |
| ter\_ |     |   | enous |   | chemical was tested | > only routes of    |
|  Note |     |   | injec |   | in the species, the | > administration    |
|       |     |   | tion; |   | field entry will be | > with positive     |
| ##    |     |   |       |   | one of the          | > tests in the      |
|  TD50 |     |   | TD50  |   | following:          | > CPDB.             |
| _Dog\ |     |   | is    |   |                     | >                   |
| _ Pri |     |   | har   |   | > " no positive     | > m = More than one |
| mates |     |   | monic |   | > results" = all    | > positive test in  |
| _Note |     |   | mean  |   | > experiments in    | > the species in    |
|       |     |   | of    |   | > the species group | > the CPDB; in this |
|       |     |   | more  |   | > were negative,    | > case the reported |
|       |     |   | than  |   | > i.e. not          | > TD50 is the       |
|       |     |   | one   |   | > carcinogenic      | > harmonic mean of  |
|       |     |   | pos   |   | >                   | > those positive    |
|       |     |   | itive |   | > "NTP bioassay     | > results \[7\].    |
|       |     |   | test; |   | > inadequate" =     | >                   |
|       |     |   |       |   | > NCI/NTP bioassays | > n = "no positive  |
|       |     |   | no    |   | > were the only     | > results are       |
|       |     |   | pos   |   | > available         | > statistically     |
|       |     |   | itive |   | > experiments in    | > significant"      |
|       |     |   | re    |   | > the species, and  | > corresponding to  |
|       |     |   | sults |   | > results for both  | > the CPDB text:    |
|       |     |   | are   |   | > sexes in the      | > "No results that  |
|       |     |   | sta   |   | > species were      | > were evaluated as |
|       |     |   | tisti |   | > evaluated by      | > positive for this |
|       |     |   | cally |   | > NCI/NTP as        | > species in the    |
|       |     |   | si    |   | > inadequate        | > CPDB are          |
|       |     |   | gnifi |   |                     | > statistically     |
|       |     |   | cant; |   |                     | > significant       |
|       |     |   |       |   |                     | > (p\<0.1)."        |
|       |     |   | gr    |   |                     | >                   |
|       |     |   | eater |   |                     | > v = Variation is  |
|       |     |   | than  |   |                     | > greater than      |
|       |     |   | ten   |   |                     | > ten-fold among    |
|       |     |   | -fold |   |                     | > statistically     |
|       |     |   | vari  |   |                     | > significant       |
|       |     |   | ation |   |                     | > (p\<0.1) TD50     |
|       |     |   | among |   |                     | > values from       |
|       |     |   | TD50  |   |                     | > different         |
|       |     |   | v     |   |                     | > positive          |
|       |     |   | alues |   |                     | > experiments in    |
|       |     |   | for   |   |                     | > the species.      |
|       |     |   | pos   |   |                     |                     |
|       |     |   | itive |   |                     | Abbreviations from  |
|       |     |   | res   |   |                     | the original CPDB   |
|       |     |   | ults; |   |                     | Summary Tables      |
|       |     |   |       |   |                     | appearing in the    |
|       |     |   | TD50  |   |                     | TD50 fields were    |
|       |     |   | value |   |                     | converted to the    |
|       |     |   | is    |   |                     | following DSSTox    |
|       |     |   | ove   |   |                     | text equivalents:   |
|       |     |   | resti |   |                     |                     |
|       |     |   | mated |   |                     | > "-" = "no         |
|       |     |   | as    |   |                     | > positive results" |
|       |     |   | upper |   |                     | > (formerly NP);    |
|       |     |   | 99%   |   |                     | >                   |
|       |     |   | confi |   |                     | > "I" = "NTP        |
|       |     |   | dence |   |                     | > bioassay          |
|       |     |   | limit |   |                     | > inadequate"       |
|       |     |   | from  |   |                     | > (formerly IA)     |
|       |     |   | study |   |                     | > indicates NCI/NTP |
|       |     |   | with  |   |                     | > bioassays were    |
|       |     |   | 100%  |   |                     | > the only          |
|       |     |   | tumor |   |                     | > available         |
|       |     |   | inci  |   |                     | > experiments and   |
|       |     |   | dence |   |                     | > both sexes in the |
|       |     |   | but   |   |                     | > species were      |
|       |     |   | no    |   |                     | > evaluated as      |
|       |     |   | lifet |   |                     | > inadequate        |
|       |     |   | able; |   |                     | >                   |
|       |     |   |       |   |                     | > "." = *blank*     |
|       |     |   | TD5   |   |                     | > indicates no data |
|       |     |   | 0_Rat |   |                     | > are available for |
|       |     |   | _mmol |   |                     | > that chemical and |
|       |     |   | was   |   |                     | > species or        |
|       |     |   | not   |   |                     | > species-sex       |
|       |     |   | calcu |   |                     | > category          |
|       |     |   | lated |   |                     | >                   |
|       |     |   | for   |   |                     | > P = harmonic mean |
|       |     |   | this  |   |                     | > of TD50 includes  |
|       |     |   | mix   |   |                     | > a value for upper |
|       |     |   | ture, |   |                     | > 99% confidence    |
|       |     |   | but   |   |                     | > limit from study  |
|       |     |   | Acti  |   |                     | > with 100% tumor   |
|       |     |   | viity |   |                     | > incidence but no  |
|       |     |   | Score |   |                     | > lifetable         |
|       |     |   | is    |   |                     | >                   |
|       |     |   | ass   |   |                     | > \< = TD50 value   |
|       |     |   | igned |   |                     | > is overestimated  |
|       |     |   | value |   |                     | > as upper 99%      |
|       |     |   | of    |   |                     | > confidence limit  |
|       |     |   | \     |   |                     | > from study with   |
|       |     |   | "50\" |   |                     | > 100% tumor        |
|       |     |   | to    |   |                     | > incidence but no  |
|       |     |   | ind   |   |                     | > lifetable         |
|       |     |   | icate |   |                     |                     |
|       |     |   | ac    |   |                     | In the CPDB Summary |
|       |     |   | tive; |   |                     | Table for Non-Human |
|       |     |   |       |   |                     | Primates, TD50      |
|       |     |   | TD50  |   |                     | results were        |
|       |     |   | not   |   |                     | reported for only a |
|       |     |   | calcu |   |                     | single chemical in  |
|       |     |   | lated |   |                     | the case of either  |
|       |     |   | by    |   |                     | the Tree Shrew and  |
|       |     |   | CPDB  |   |                     | Bush Baby; in each  |
|       |     |   | So    |   |                     | case, for a         |
|       |     |   | urce; |   |                     | chemical already    |
|       |     |   |       |   |                     | present in another  |
|       |     |   | TD50  |   |                     | species CPDB        |
|       |     |   | value |   |                     | Summary Table. The  |
|       |     |   | less  |   |                     | single data result  |
|       |     |   | than  |   |                     | in each case is     |
|       |     |   | the   |   |                     | listed in the       |
|       |     |   | rep   |   |                     | **TD50_             |
|       |     |   | orted |   |                     | Dog_Primates_Note** |
|       |     |   | upper |   |                     | field with a        |
|       |     |   | confi |   |                     | corresponding       |
|       |     |   | dence |   |                     | species entry in    |
|       |     |   | l     |   |                     | the **Species**     |
|       |     |   | imit; |   |                     | field, i.e.         |
|       |     |   |       |   |                     | separate            |
|       |     |   | har   |   |                     | **TD50\_\...** and  |
|       |     |   | monic |   |                     | **                  |
|       |     |   | mean  |   |                     | TargetSites\_\...** |
|       |     |   | of    |   |                     | fields are not      |
|       |     |   | TD50  |   |                     | included for these  |
|       |     |   | inc   |   |                     | two species in      |
|       |     |   | ludes |   |                     | CPDBAS.             |
|       |     |   | a     |   |                     |                     |
|       |     |   | value |   |                     | *Modified field     |
|       |     |   | for   |   |                     | entries (January    |
|       |     |   | the   |   |                     | 2008).*             |
|       |     |   | upper |   |                     |                     |
|       |     |   | 99%   |   |                     |                     |
|       |     |   | confi |   |                     |                     |
|       |     |   | dence |   |                     |                     |
|       |     |   | l     |   |                     |                     |
|       |     |   | imit/ |   |                     |                     |
|       |     |   |       |   |                     |                     |
|       |     |   | no    |   |                     |                     |
|       |     |   | pos   |   |                     |                     |
|       |     |   | itive |   |                     |                     |
|       |     |   | res   |   |                     |                     |
|       |     |   | ults/ |   |                     |                     |
|       |     |   |       |   |                     |                     |
|       |     |   | NTP   |   |                     |                     |
|       |     |   | bio   |   |                     |                     |
|       |     |   | assay |   |                     |                     |
|       |     |   | i     |   |                     |                     |
|       |     |   | nadeq |   |                     |                     |
|       |     |   | uate/ |   |                     |                     |
|       |     |   |       |   |                     |                     |
|       |     |   | *b    |   |                     |                     |
|       |     |   | lank* |   |                     |                     |
+-------+-----+---+-------+---+---------------------+---------------------+
| ## Ta | d   |   | [     |   | Target sites are    | These fields appear |
| rgetS | efi |   | adr]{ |   | reported for each   | under the column    |
| ites_ | ned |   | .unde |   | sex-species group   | headings "Rat       |
| Rat\_ | t   |   | rline |   | with a positive     | target sites",      |
|       | ext |   | }enal |   | result in the CPDB. | "Mouse target       |
| ## M  |     |   | g     |   | Target sites are    | sites" and "Target  |
| ale/  |     |   | land; |   | identified on the   | sites" in the       |
|       |     |   |       |   | basis of a positive | original CPDB       |
| *     |     |   | >     |   | opinion by the      | Summary Tables. The |
| *Targ |     |   |  [bon |   | published author    | field names have    |
| etSit |     |   | ]{.un |   | for the particular  | been separated and  |
| es_Ra |     |   | derli |   | site, in any        | standardized in the |
| t\_** |     |   | ne}e; |   | experiment in the   | DSSTox SDF files.   |
|       |     |   | >     |   | species-sex or      |                     |
| *     |     |   | > [c  |   | species, using all  | The original CPDB   |
| *Fema |     |   | li]{. |   | results from both   | Summary Tables      |
| le/** |     |   | under |   | the general         | reports tumor       |
|       |     |   | line} |   | literature and      | target sites as 3   |
| *     |     |   | toral |   | NCI/NTP bioassays.  | letter mnemonic     |
| *Targ |     |   | > g   |   | If a chemical has   | codes, e.g.         |
| etSit |     |   | land; |   | two or more target  | adr=adrenal gland.  |
| es_Ra |     |   | >     |   | sites listed, the   | In this and         |
| t\_** |     |   | >     |   | results may be from | subsequent versions |
|       |     |   |  [eso |   | different           | of CPDBAS, the 3    |
| **Bo  |     |   | ]{.un |   | experiments, and a  | letter codes have   |
| thSex |     |   | derli |   | single site may be  | been replaced by    |
| es/** |     |   | ne}ph |   | a target organ in   | the corresponding   |
|       |     |   | agus; |   | more than one       | target site.        |
| **    |     |   | >     |   | experiment \[2,3\]. |                     |
| Targe |     |   | > [e  |   | CPDB data organized | Abbreviations from  |
| tSite |     |   | ]{.un |   | by target site have | the original CPDB   |
| s\_** |     |   | derli |   | been published by   | Summary Tables      |
|       |     |   | ne}ar |   | Gold et al. \[3\]   | appearing in the    |
| **Mou |     |   | > [   |   | and are updated on  | Target site fields  |
| se_Ma |     |   | Zy]{. |   | the CPDB website to | were converted to   |
| le/** |     |   | under |   | include all results | the following       |
|       |     |   | line} |   | in CPDB to date at: | DSSTox text         |
| **    |     |   | mbals |   | <http://poten       | equivalents:        |
| Targe |     |   | > g   |   | cy.berkeley.edu/pat |                     |
| tSite |     |   | land; |   | hology.table.html>. | > "-" = "no         |
| s\_** |     |   | >     |   |                     | > positive results" |
|       |     |   | > [ga |   | nasal cavity        | > (formerly NP)     |
| **    |     |   | l]{.u |   | (includes tissues   | >                   |
| Mouse |     |   | nderl |   | of the nose, nasal  | > "I" = "NTP        |
| _Fema |     |   | ine}l |   | turbinates,         | > bioassay          |
| le/** |     |   | > bla |   | paranasal sinuses   | > inadequate"       |
|       |     |   | dder; |   | and trachea);       | > (formerly IA)     |
| **    |     |   | >     |   |                     | > indicates NCI/NTP |
| Targe |     |   | > [ha |   | oral cavity         | > bioassays were    |
| tSite |     |   | ]{.un |   | (includes tissues   | > the only          |
| s\_** |     |   | derli |   | of the mouth,       | > available         |
|       |     |   | ne}rd |   | oropharynx,         | > experiments and   |
| **Mou |     |   | erian |   | pharynx, and        | > both sexes in the |
| se_Bo |     |   | >     |   | larynx);            | > species were      |
| thSex |     |   | [g]{. |   |                     | > evaluated as      |
| es/** |     |   | under |   | Maltoni head        | > inadequate        |
|       |     |   | line} |   | cancers = A mix of  | >                   |
| **    |     |   | land; |   | carcinomas of the   | > "u" = "no         |
| Targe |     |   | >     |   | ear duct, Zymbal's  | > positive results  |
| tSite |     |   | >     |   | gland, oral cavity  | > -- CBDP           |
| s\_** |     |   | [h]{. |   | or nasal cavity     | > evaluation based  |
|       |     |   | under |   | were combined by    | > on NCI Technical  |
| **    |     |   | line} |   | single author,      | > Report" where in  |
| Hamst |     |   | e[m]{ |   | Maltoni, in his     | > these few cases   |
| er_Ma |     |   | .unde |   | category "Head      | > an NCI Technical  |
| le/** |     |   | rline |   | cancers", which he  | > Report prior to   |
|       |     |   | }at[o |   | reports as induced  | > 1983 did not      |
| **    |     |   | ]{.un |   | by the chemical.    | > evaluate the      |
| Targe |     |   | derli |   |                     | > evidence as       |
| tSite |     |   | ne}po |   | **TargetSites\_*sp  | > \"carcinogenic"   |
| s\_** |     |   | ietic |   | ecies*\_BothSexes** | > and, later, NTP   |
|       |     |   | > sy  |   | is used for         | > reassigned the    |
| **Ha  |     |   | stem; |   | experiments where   | > level of evidence |
| mster |     |   | >     |   | results in the      | > of \"positive".   |
| _Fema |     |   | > [   |   | general literature  | >                   |
| le/** |     |   | kid]{ |   | are reported only   | > "." = *blank* (no |
|       |     |   | .unde |   | for males and       | > experiment        |
| **    |     |   | rline |   | females combined,   | > reported)         |
| Targe |     |   | }ney; |   | with a positive     |                     |
| tSite |     |   | >     |   | author\'s opinion   | In the CPDB Summary |
| s\_** |     |   | > [l] |   | for the particular  | Table for Non-Human |
|       |     |   | {.und |   | site.               | Primates,           |
| **H   |     |   | erlin |   |                     | **TargetSites**     |
| amste |     |   | e}ar[ |   | If a tumor target   | were reported for   |
| r\_** |     |   | g]{.u |   | site is not         | only a single       |
|       |     |   | nderl |   | reported for the    | chemical in the     |
| **Bo  |     |   | ine}e |   | listed chemical and | case of both the    |
| thSex |     |   | >     |   | species/sex cell,   | Tree Shrew and Bush |
| es/** |     |   |  [i]{ |   | the field entry     | Baby; in each case, |
|       |     |   | .unde |   | will be one of the  | for a chemical      |
| **Tar |     |   | rline |   | following:          | already present in  |
| getSi |     |   | }ntes |   |                     | another species     |
| tes_D |     |   | tine; |   | > "no positive      | CPDB Summary Table. |
| og/** |     |   | >     |   | > results" =        | The single data     |
|       |     |   | >     |   | > indicates that    | result in each case |
| **    |     |   | [liv] |   | > all experiments   | is listed in the    |
| Targe |     |   | {.und |   | > in the sex        | **TD50_             |
| tSite |     |   | erlin |   | > species group     | Dog_Primates_Note** |
| s\_** |     |   | e}er; |   | > were negative,    | field with a        |
|       |     |   | >     |   | > i.e. not          | corresponding       |
| ## Rh |     |   | >     |   | > carcinogenic.     | species entry in    |
| esus/ |     |   |  [lun |   | >                   | the **Species**     |
|       |     |   | ]{.un |   | > "no positive      | field, i.e.         |
| #     |     |   | derli |   | > results -- CPDB   | separate            |
| # Tar |     |   | ne}g; |   | > evaluation based  | **TD50\_\...** and  |
| getSi |     |   | >     |   | > on NCI Technical  | **                  |
| tes\_ |     |   | >     |   | > Report" = In      | TargetSites\_\...** |
|       |     |   |  [me] |   | > these few cases   | fields are not      |
| ## C  |     |   | {.und |   | > an NCI Technical  | included for these  |
| ynomo |     |   | erlin |   | > Report prior to   | two species in      |
| lgus/ |     |   | e}s[o |   | > 1983 did not      | CPDBAS.             |
|       |     |   | ]{.un |   | > evaluate the      |                     |
|       |     |   | derli |   | > evidence as       | In the CPDB Summary |
|       |     |   | ne}va |   | > \"carcinogenic"   | Tables for Rats,    |
|       |     |   | rium; |   | > and, later, NTP   | Mice, and Hamsters, |
|       |     |   | >     |   | > reassigned the    | the notation (B) is |
|       |     |   | > [   |   | > level of evidence | used in conjunction |
|       |     |   | m]{.u |   | > of \"positive".   | with a species-sex  |
|       |     |   | nderl |   | >                   | target site, e.g.,  |
|       |     |   | ine}a |   | > "NTP bioassay     | "adr (B)" to        |
|       |     |   | mmary |   | > inadequate" =     | indicate that a     |
|       |     |   | >     |   | > NCI/NTP bioassays | study reported      |
|       |     |   | [gl]{ |   | > were the only     | tumors at the       |
|       |     |   | .unde |   | > available         | adrenal gland only  |
|       |     |   | rline |   | > experiments in    | for the two sexes   |
|       |     |   | }and; |   | > the species and   | combined. This      |
|       |     |   | >     |   | > results for both  | notation would      |
|       |     |   | > [m  |   | > sexes in the      | appear for the      |
|       |     |   | ix]{. |   | > species were      | target site under   |
|       |     |   | under |   | > evaluated by      | both Male and       |
|       |     |   | line} |   | > NCI/NTP as        | Female headings     |
|       |     |   | ture; |   | > inadequate.       | unless one of two   |
|       |     |   | >     |   |                     | conditions held:    |
|       |     |   | >     |   | "*blank*" or null   | (1) positive        |
|       |     |   |  [my] |   | entry indicates no  | results were        |
|       |     |   | {.und |   | experiment reported | available for the   |
|       |     |   | erlin |   | in CPDB for that    | target site in the  |
|       |     |   | e}o[c |   | chemical and        | other sex of the    |
|       |     |   | ]{.un |   | species-sex         | species; or (2)     |
|       |     |   | derli |   | category.           | negative results    |
|       |     |   | ne}ar |   |                     | were reported for   |
|       |     |   | dium; |   | The 3-letter        | the other sex of    |
|       |     |   | >     |   | abbreviation used   | the species. A "B-" |
|       |     |   | >     |   | for tumor sites in  | would be listed     |
|       |     |   |  [nas |   | the original CPDB   | alone (i.e.,        |
|       |     |   | ]{.un |   | Summary Tables is   | without target site |
|       |     |   | derli |   | underlined in the   | codes) if negative  |
|       |     |   | ne}al |   | expanded text of    | results were only   |
|       |     |   | > ca  |   | the *Allowable      | found in a study    |
|       |     |   | vity; |   | Entries*.           | where the two sexes |
|       |     |   | >     |   |                     | were combined.      |
|       |     |   | >     |   |                     | Since these results |
|       |     |   | [n]{. |   |                     | are not resolved to |
|       |     |   | under |   |                     | species-sex, we     |
|       |     |   | line} |   |                     | have created        |
|       |     |   | e[rv] |   |                     | separate fields to  |
|       |     |   | {.und |   |                     | accommodate this    |
|       |     |   | erlin |   |                     | information:        |
|       |     |   | e}ous |   |                     | **TargetSit         |
|       |     |   | > sy  |   |                     | es_Rat_BothSexes**\ |
|       |     |   | stem; |   |                     | **TargetSites       |
|       |     |   | >     |   |                     | _Mouse_BothSexes**\ |
|       |     |   | > [or |   |                     | **TargetSites_      |
|       |     |   | ]{.un |   |                     | Hamster_BothSexes** |
|       |     |   | derli |   |                     |                     |
|       |     |   | ne}al |   |                     | Non-*blank* entries |
|       |     |   | > [   |   |                     | in these fields     |
|       |     |   | c]{.u |   |                     | only occur under    |
|       |     |   | nderl |   |                     | the same conditions |
|       |     |   | ine}a |   |                     | reported in the     |
|       |     |   | vity; |   |                     | CPDB Summary        |
|       |     |   | >     |   |                     | Tables, i.e. if     |
|       |     |   | >     |   |                     | combined-sex        |
|       |     |   | [ova] |   |                     | results are         |
|       |     |   | {.und |   |                     | available and       |
|       |     |   | erlin |   |                     | species-sex results |
|       |     |   | e}ry; |   |                     | are unavailable for |
|       |     |   | >     |   |                     | either sex. The     |
|       |     |   | > [pa |   |                     | **                  |
|       |     |   | n]{.u |   |                     | TargetSites\_\...** |
|       |     |   | nderl |   |                     | for dogs and        |
|       |     |   | ine}c |   |                     | non-human primate   |
|       |     |   | reas; |   |                     | species (rhesus,    |
|       |     |   | >     |   |                     | cynomolgus, tree    |
|       |     |   | >     |   |                     | shrew, bush baby)   |
|       |     |   |  [per |   |                     | are reported        |
|       |     |   | ]{.un |   |                     | without sex         |
|       |     |   | derli |   |                     | specification or    |
|       |     |   | ne}it |   |                     | with sexes          |
|       |     |   | oneal |   |                     | combined.           |
|       |     |   | > ca  |   |                     |                     |
|       |     |   | vity; |   |                     | In the CPDB Summary |
|       |     |   | >     |   |                     | Tables, four        |
|       |     |   | > [pi |   |                     | chemicals in rats   |
|       |     |   | t]{.u |   |                     | include the         |
|       |     |   | nderl |   |                     | footnote "H" to     |
|       |     |   | ine}u |   |                     | denote a positive   |
|       |     |   | itary |   |                     | opinion for a       |
|       |     |   | > g   |   |                     | consolidated site   |
|       |     |   | land; |   |                     | "head tumors", by   |
|       |     |   | >     |   |                     | only a single       |
|       |     |   | > [pr |   |                     | research group.     |
|       |     |   | e]{.u |   |                     | Maltoni et al.      |
|       |     |   | nderl |   |                     | evaluated head as a |
|       |     |   | ine}p |   |                     | target site for a   |
|       |     |   | utial |   |                     | combination of      |
|       |     |   | > g   |   |                     | carcinomas at       |
|       |     |   | land; |   |                     | various sites in    |
|       |     |   | >     |   |                     | the head (ear duct, |
|       |     |   | > [pr |   |                     | Zymbal's gland,     |
|       |     |   | o]{.u |   |                     | nasal cavity, or    |
|       |     |   | nderl |   |                     | oral cavity). When  |
|       |     |   | ine}s |   |                     | this result has     |
|       |     |   | tate; |   |                     | confirming results  |
|       |     |   | >     |   |                     | from other studies  |
|       |     |   | >     |   |                     | for either nas or   |
|       |     |   |  [ski |   |                     | orc target sites in |
|       |     |   | ]{.un |   |                     | the head, it is     |
|       |     |   | derli |   |                     | reported as nash    |
|       |     |   | ne}n; |   |                     | and orch in the     |
|       |     |   | >     |   |                     | CPDB Summary Table. |
|       |     |   | >     |   |                     | When no other       |
|       |     |   |  [sm] |   |                     | positive results    |
|       |     |   | {.und |   |                     | are reported, the   |
|       |     |   | erlin |   |                     | result is           |
|       |     |   | e}all |   |                     | designated "+H" in  |
|       |     |   | >     |   |                     | the CPDB Summary    |
|       |     |   |  [i]{ |   |                     | Table \[4\]. Both   |
|       |     |   | .unde |   |                     | "H" and "+H" have   |
|       |     |   | rline |   |                     | been replaced with  |
|       |     |   | }ntes |   |                     | "Maltoni head       |
|       |     |   | tine; |   |                     | cancers" in the     |
|       |     |   | >     |   |                     | CPDBAS file. This   |
|       |     |   | > [   |   |                     | occurs either       |
|       |     |   | spl]{ |   |                     | alone, or following |
|       |     |   | .unde |   |                     | a target site, such |
|       |     |   | rline |   |                     | as nasal or oral    |
|       |     |   | }een; |   |                     | cavity.             |
|       |     |   | >     |   |                     |                     |
|       |     |   | > [s  |   |                     | In the CPDB Summary |
|       |     |   | to]{. |   |                     | Tables, the         |
|       |     |   | under |   |                     | footnote indicators |
|       |     |   | line} |   |                     | "L, a, and x" are   |
|       |     |   | mach; |   |                     | listed for 3 or     |
|       |     |   | >     |   |                     | fewer compounds. In |
|       |     |   | > [   |   |                     | the DSSTox CPDBAS   |
|       |     |   | sub]{ |   |                     | data files, these   |
|       |     |   | .unde |   |                     | footnotes are       |
|       |     |   | rline |   |                     | deleted from the    |
|       |     |   | }cuta |   |                     | Target Sites field  |
|       |     |   | neous |   |                     | and the             |
|       |     |   | > ti  |   |                     | corresponding text  |
|       |     |   | ssue; |   |                     | has been            |
|       |     |   | >     |   |                     | incorporated into   |
|       |     |   | > all |   |                     | either the          |
|       |     |   | >     |   |                     | corresponding       |
|       |     |   |  [t]{ |   |                     | **TD50              |
|       |     |   | .unde |   |                     | \_*species*\_Note** |
|       |     |   | rline |   |                     | field or the        |
|       |     |   | }umor |   |                     | **NT                |
|       |     |   | > [   |   |                     | P_TechnicalReport** |
|       |     |   | b]{.u |   |                     | field.              |
|       |     |   | nderl |   |                     |                     |
|       |     |   | ine}e |   |                     |                     |
|       |     |   | aring |   |                     |                     |
|       |     |   | > [a  |   |                     |                     |
|       |     |   | ]{.un |   |                     |                     |
|       |     |   | derli |   |                     |                     |
|       |     |   | ne}ni |   |                     |                     |
|       |     |   | mals; |   |                     |                     |
|       |     |   | >     |   |                     |                     |
|       |     |   | > [   |   |                     |                     |
|       |     |   | tes]{ |   |                     |                     |
|       |     |   | .unde |   |                     |                     |
|       |     |   | rline |   |                     |                     |
|       |     |   | }tes; |   |                     |                     |
|       |     |   | >     |   |                     |                     |
|       |     |   | > [   |   |                     |                     |
|       |     |   | thy]{ |   |                     |                     |
|       |     |   | .unde |   |                     |                     |
|       |     |   | rline |   |                     |                     |
|       |     |   | }roid |   |                     |                     |
|       |     |   | > g   |   |                     |                     |
|       |     |   | land; |   |                     |                     |
|       |     |   | >     |   |                     |                     |
|       |     |   | > [   |   |                     |                     |
|       |     |   | u]{.u |   |                     |                     |
|       |     |   | nderl |   |                     |                     |
|       |     |   | ine}r |   |                     |                     |
|       |     |   | inary |   |                     |                     |
|       |     |   | > [b  |   |                     |                     |
|       |     |   | l]{.u |   |                     |                     |
|       |     |   | nderl |   |                     |                     |
|       |     |   | ine}a |   |                     |                     |
|       |     |   | dder; |   |                     |                     |
|       |     |   | >     |   |                     |                     |
|       |     |   | > [   |   |                     |                     |
|       |     |   | ute]{ |   |                     |                     |
|       |     |   | .unde |   |                     |                     |
|       |     |   | rline |   |                     |                     |
|       |     |   | }rus; |   |                     |                     |
|       |     |   | >     |   |                     |                     |
|       |     |   | > [   |   |                     |                     |
|       |     |   | vag]{ |   |                     |                     |
|       |     |   | .unde |   |                     |                     |
|       |     |   | rline |   |                     |                     |
|       |     |   | }ina; |   |                     |                     |
|       |     |   | >     |   |                     |                     |
|       |     |   | > [   |   |                     |                     |
|       |     |   | v]{.u |   |                     |                     |
|       |     |   | nderl |   |                     |                     |
|       |     |   | ine}a |   |                     |                     |
|       |     |   | [sc]{ |   |                     |                     |
|       |     |   | .unde |   |                     |                     |
|       |     |   | rline |   |                     |                     |
|       |     |   | }ular |   |                     |                     |
|       |     |   | > sy  |   |                     |                     |
|       |     |   | stem; |   |                     |                     |
|       |     |   | >     |   |                     |                     |
|       |     |   | > Ma  |   |                     |                     |
|       |     |   | ltoni |   |                     |                     |
|       |     |   | > [h] |   |                     |                     |
|       |     |   | {.und |   |                     |                     |
|       |     |   | erlin |   |                     |                     |
|       |     |   | e}ead |   |                     |                     |
|       |     |   | > can |   |                     |                     |
|       |     |   | cers; |   |                     |                     |
|       |     |   | >     |   |                     |                     |
|       |     |   | > no  |   |                     |                     |
|       |     |   | > pos |   |                     |                     |
|       |     |   | itive |   |                     |                     |
|       |     |   | > res |   |                     |                     |
|       |     |   | ults; |   |                     |                     |
|       |     |   | >     |   |                     |                     |
|       |     |   | > NTP |   |                     |                     |
|       |     |   | > ass |   |                     |                     |
|       |     |   | igned |   |                     |                     |
|       |     |   | >     |   |                     |                     |
|       |     |   | level |   |                     |                     |
|       |     |   | > of  |   |                     |                     |
|       |     |   | > evi |   |                     |                     |
|       |     |   | dence |   |                     |                     |
|       |     |   | >     |   |                     |                     |
|       |     |   |  posi |   |                     |                     |
|       |     |   | tive; |   |                     |                     |
|       |     |   | >     |   |                     |                     |
|       |     |   | > NTP |   |                     |                     |
|       |     |   | > bio |   |                     |                     |
|       |     |   | assay |   |                     |                     |
|       |     |   | > i   |   |                     |                     |
|       |     |   | nadeq |   |                     |                     |
|       |     |   | uate/ |   |                     |                     |
|       |     |   | >     |   |                     |                     |
|       |     |   | > *b  |   |                     |                     |
|       |     |   | lank* |   |                     |                     |
+-------+-----+---+-------+---+---------------------+---------------------+
| *     | d   |   | ac    |   | An assignment of    | Summary activity    |
| *Acti | efi |   | tive/ |   | categorical         | call for use in     |
| vityO | ned |   |       |   | carcinogenic        | PubChem and         |
| utcom | t   |   | inac  |   | activity based on   | structure-activity  |
| e_CPD | ext |   | tive/ |   | evidence for or     | relationship        |
| BAS_R |     |   |       |   | against activity    | studies.            |
| at/** |     |   | un    |   | within a species or |                     |
|       |     |   | speci |   | species group as    | *New fields added   |
| **A   |     |   | fied/ |   | provided in the     | to v5b.*            |
| ctivi |     |   |       |   | CPDB Summary Table  |                     |
| tyOut |     |   | *b    |   | (e.g., Rat, Mouse,  |                     |
| come_ |     |   | lank* |   | etc):               |                     |
| CPDBA |     |   |       |   |                     |                     |
| S_Mou |     |   |       |   | "active" = one or   |                     |
| se/** |     |   |       |   | more TD50 and tumor |                     |
|       |     |   |       |   | site listed for one |                     |
| **Act |     |   |       |   | or more             |                     |
| ivity |     |   |       |   | species-specific    |                     |
| Outco |     |   |       |   | (e.g., Rat)         |                     |
| me_CP |     |   |       |   | carcinogenicity     |                     |
| DBAS_ |     |   |       |   | sex/species cell    |                     |
| Hamst |     |   |       |   | (e.g., Rat Male,    |                     |
| er/** |     |   |       |   | Rat Female, Rat     |                     |
|       |     |   |       |   | Both);              |                     |
| **Act |     |   |       |   |                     |                     |
| ivity |     |   |       |   | "inactive" = no     |                     |
| Outco |     |   |       |   | TD50 or tumor site  |                     |
| me_CP |     |   |       |   | is listed AND one   |                     |
| DBAS_ |     |   |       |   | or more \"no        |                     |
| Dog_P |     |   |       |   | positive results\"  |                     |
| rimat |     |   |       |   | entry for one or    |                     |
| es/** |     |   |       |   | more species        |                     |
|       |     |   |       |   | specific (e.g.,     |                     |
| *(no  |     |   |       |   | Rat)                |                     |
| spa   |     |   |       |   | carcinogenicity     |                     |
| ces)* |     |   |       |   | sex/species cell    |                     |
|       |     |   |       |   | (e.g., Rat Male,    |                     |
|       |     |   |       |   | Rat Female, Rat     |                     |
|       |     |   |       |   | Both), i.e. one or  |                     |
|       |     |   |       |   | more experiments    |                     |
|       |     |   |       |   | are reported in the |                     |
|       |     |   |       |   | CPDB for species,   |                     |
|       |     |   |       |   | but none are        |                     |
|       |     |   |       |   | positive;           |                     |
|       |     |   |       |   |                     |                     |
|       |     |   |       |   | "unspecified" =     |                     |
|       |     |   |       |   | NCI/NTP bioassays   |                     |
|       |     |   |       |   | were the only       |                     |
|       |     |   |       |   | available           |                     |
|       |     |   |       |   | experiments and     |                     |
|       |     |   |       |   | both sexes in the   |                     |
|       |     |   |       |   | species were        |                     |
|       |     |   |       |   | evaluated by        |                     |
|       |     |   |       |   | NCI/NTP as          |                     |
|       |     |   |       |   | inadequate,         |                     |
|       |     |   |       |   | corresponds to "NTP |                     |
|       |     |   |       |   | bioassay            |                     |
|       |     |   |       |   | inadequate" entry   |                     |
|       |     |   |       |   | in TargetSites      |                     |
|       |     |   |       |   | field               |                     |
|       |     |   |       |   |                     |                     |
|       |     |   |       |   | "*blank*" or null   |                     |
|       |     |   |       |   | entry indicates no  |                     |
|       |     |   |       |   | experiments         |                     |
|       |     |   |       |   | reported in CPDB    |                     |
|       |     |   |       |   | for that chemical   |                     |
|       |     |   |       |   | and species         |                     |
|       |     |   |       |   | category.           |                     |
|       |     |   |       |   |                     |                     |
|       |     |   |       |   | All substance       |                     |
|       |     |   |       |   | records in CPDBAS   |                     |
|       |     |   |       |   | having a            |                     |
|       |     |   |       |   | non-*blank* entry   |                     |
|       |     |   |       |   | in the              |                     |
|       |     |   |       |   | **ActivityO         |                     |
|       |     |   |       |   | utcome_CPDBAS_Rat** |                     |
|       |     |   |       |   | field will have a   |                     |
|       |     |   |       |   | corresponding entry |                     |
|       |     |   |       |   | in the              |                     |
|       |     |   |       |   | **Activit           |                     |
|       |     |   |       |   | yScore_CPDBAS_Rat** |                     |
|       |     |   |       |   | field; likewise for |                     |
|       |     |   |       |   | corresponding Mouse |                     |
|       |     |   |       |   | and Hamster fields. |                     |
+-------+-----+---+-------+---+---------------------+---------------------+
| **A   | i   |   | IN    |   | > Mapping of LOG10  | Summary activity    |
| ctivi | nte |   | TEGER |   | > (1/**TD50\        | ranking for use in  |
| tySco | ger |   | \[0-  |   | _*species*\_mmol**) | PubChem and         |
| re\_\ |     |   | 100\] |   | > values spanning   | structure-activity  |
| CPD   |     |   |       |   | > range \[MIN,      | relationship        |
| BAS_R |     |   | *b    |   | > MAX\] onto        | studies.            |
| at/** |     |   | lank* |   | > Integer 1-100     |                     |
|       |     |   |       |   | > Activity range    | *New fields added   |
| **A   |     |   |       |   | > (for carcinogenic | to v5b.*            |
| ctivi |     |   |       |   | > compounds), where |                     |
| tySco |     |   |       |   | > 100 represents    |                     |
| re\_\ |     |   |       |   | > the highest       |                     |
| CPDBA |     |   |       |   | > potency and 1 the |                     |
| S_Mou |     |   |       |   | > lowest:           |                     |
| se/** |     |   |       |   |                     |                     |
|       |     |   |       |   | ActivityScore = 100 |                     |
| **A   |     |   |       |   | \*                  |                     |
| ctivi |     |   |       |   | INTEGER\[(          |                     |
| tySco |     |   |       |   | log10(1/Activity) - |                     |
| re\_\ |     |   |       |   | MIN)/(MAX -- MIN)\] |                     |
| CP    |     |   |       |   |                     |                     |
| DBAS_ |     |   |       |   | ActivityScore (0)   |                     |
| Hamst |     |   |       |   | is assigned when    |                     |
| er/** |     |   |       |   | corresponding       |                     |
|       |     |   |       |   | **ActivityOut       |                     |
| *(no  |     |   |       |   | come_CPDBAS\_\...** |                     |
| spa   |     |   |       |   | field entry for     |                     |
| ces)* |     |   |       |   | species is          |                     |
|       |     |   |       |   | "inactive" or       |                     |
|       |     |   |       |   | "unspecified".      |                     |
|       |     |   |       |   |                     |                     |
|       |     |   |       |   | "*blank*" or null   |                     |
|       |     |   |       |   | entry indicates no  |                     |
|       |     |   |       |   | experiments         |                     |
|       |     |   |       |   | reported in CPDB    |                     |
|       |     |   |       |   | for that chemical   |                     |
|       |     |   |       |   | and species-sex     |                     |
|       |     |   |       |   | category.           |                     |
|       |     |   |       |   |                     |                     |
|       |     |   |       |   | *Note:* In a small  |                     |
|       |     |   |       |   | number of "active"  |                     |
|       |     |   |       |   | cases where         |                     |
|       |     |   |       |   | substance is        |                     |
|       |     |   |       |   | mixture with        |                     |
|       |     |   |       |   | different Molecular |                     |
|       |     |   |       |   | Weight components,  |                     |
|       |     |   |       |   | such that           |                     |
|       |     |   |       |   | **TD50_Rat_mmol**   |                     |
|       |     |   |       |   | and                 |                     |
|       |     |   |       |   | **TD50_Mouse_mmol** |                     |
|       |     |   |       |   | could not be        |                     |
|       |     |   |       |   | calculated, the     |                     |
|       |     |   |       |   | **ActivityScore**   |                     |
|       |     |   |       |   | was arbitrarily     |                     |
|       |     |   |       |   | assigned a value of |                     |
|       |     |   |       |   | "50" to indicate    |                     |
|       |     |   |       |   | activity.           |                     |
|       |     |   |       |   |                     |                     |
|       |     |   |       |   | All substance       |                     |
|       |     |   |       |   | records in CPDBAS   |                     |
|       |     |   |       |   | having a            |                     |
|       |     |   |       |   | non-*blank* entry   |                     |
|       |     |   |       |   | in the              |                     |
|       |     |   |       |   | **ActivityO         |                     |
|       |     |   |       |   | utcome_CPDBAS_Rat** |                     |
|       |     |   |       |   | field will have a   |                     |
|       |     |   |       |   | corresponding entry |                     |
|       |     |   |       |   | in the              |                     |
|       |     |   |       |   | **Activit           |                     |
|       |     |   |       |   | yScore_CPDBAS_Rat** |                     |
|       |     |   |       |   | field; likewise for |                     |
|       |     |   |       |   | corresponding Mouse |                     |
|       |     |   |       |   | and Hamster fields. |                     |
+-------+-----+---+-------+---+---------------------+---------------------+
| *     | d   |   | ac    |   | An assignment of    | Type of             |
| *Acti | efi |   | tive/ |   | categorical         | conservative        |
| vityO | ned |   |       |   | carcinogenic        | activity call used  |
| utcom | t   |   | inac  |   | activity based on   | by the National     |
| e\_** | ext |   | tive/ |   | minimal evidence    | Toxicology Program, |
|       |     |   |       |   | for or against      | where a             |
| **S   |     |   | un    |   | activity:           | statistically       |
| ingle |     |   | speci |   |                     | significant tumor   |
| CellC |     |   | fied/ |   | "active" = one or   | site finding in a   |
| all** |     |   |       |   | more TD50 and tumor | single sex/species  |
|       |     |   |       |   | site listed for one | of rodent is        |
| *(no  |     |   |       |   | or more             | considered a        |
| spa   |     |   |       |   | carcinogenicity     | significant         |
| ces)* |     |   |       |   | sex/species cell    | carcinogenic        |
|       |     |   |       |   | (e.g., Rat Male,    | concern.            |
|       |     |   |       |   | Rat Female, etc);   |                     |
|       |     |   |       |   |                     | Summary activity    |
|       |     |   |       |   | "inactive" = no     | call for use in     |
|       |     |   |       |   | TD50 or tumor site  | PubChem and         |
|       |     |   |       |   | listed AND one or   | structure-activity  |
|       |     |   |       |   | more \"no positive  | relationship        |
|       |     |   |       |   | results\" entry for | studies.            |
|       |     |   |       |   | one or more         |                     |
|       |     |   |       |   | carcinogenicity     | *Field entries      |
|       |     |   |       |   | sex/species cell    | modified in v5d; 3  |
|       |     |   |       |   | (e.g., Rat Male,    | records for Rat     |
|       |     |   |       |   | Rat Female, etc),   | have "unspecified"  |
|       |     |   |       |   | i.e. one or more    | entry based on NTP  |
|       |     |   |       |   | experiments are     | call.*              |
|       |     |   |       |   | reported in the     |                     |
|       |     |   |       |   | CPDB, but none are  |                     |
|       |     |   |       |   | positive;           |                     |
|       |     |   |       |   |                     |                     |
|       |     |   |       |   | "unspecified" =     |                     |
|       |     |   |       |   | NCI/NTP bioassays   |                     |
|       |     |   |       |   | were the only       |                     |
|       |     |   |       |   | available           |                     |
|       |     |   |       |   | experiments and     |                     |
|       |     |   |       |   | both sexes in the   |                     |
|       |     |   |       |   | species were        |                     |
|       |     |   |       |   | evaluated by        |                     |
|       |     |   |       |   | NCI/NTP as          |                     |
|       |     |   |       |   | inadequate,         |                     |
|       |     |   |       |   | corresponds to "NTP |                     |
|       |     |   |       |   | bioassay            |                     |
|       |     |   |       |   | inadequate" entry   |                     |
|       |     |   |       |   | in TargetSites      |                     |
|       |     |   |       |   | field               |                     |
|       |     |   |       |   |                     |                     |
|       |     |   |       |   | *Note:* This field  |                     |
|       |     |   |       |   | contains no "blank" |                     |
|       |     |   |       |   | entries, since CPDB |                     |
|       |     |   |       |   | reports results of  |                     |
|       |     |   |       |   | at least one        |                     |
|       |     |   |       |   | experiment for each |                     |
|       |     |   |       |   | substance in        |                     |
|       |     |   |       |   | CPDBAS.             |                     |
+-------+-----+---+-------+---+---------------------+---------------------+
| **A   | d   |   | ac    |   | An assignment of    | CPDB Summary Table  |
| ctivi | efi |   | tive/ |   | categorical         | tumor site codes    |
| tyOut | ned |   |       |   | carcinogenic        | "mix" or "H" count  |
| come_ | t   |   | inac  |   | activity based on   | as a single site or |
| CPDBA | ext |   | tive/ |   | multicell evidence  | experimental        |
| S\_** |     |   |       |   | for or against      | observation for the |
|       |     |   | *b    |   | activity:           | purposes of this    |
| **    |     |   | lank* |   |                     | activity            |
| Multi |     |   |       |   | "active" = more     | assignment.         |
| CellC |     |   |       |   | than one TD50 or    |                     |
| all** |     |   |       |   | tumor site listed   | A result reported   |
|       |     |   |       |   | for carcinogenicity | in the CPDB Summary |
| *(no  |     |   |       |   | sex/species cells   | Table for "Both     |
| spa   |     |   |       |   | (e.g., liver, lung, | Sexes", i.e. the    |
| ces)* |     |   |       |   | or Rat Male, Rat    | experimental        |
|       |     |   |       |   | Female, etc), where | results were        |
|       |     |   |       |   | tumor sites may be  | reported in the     |
|       |     |   |       |   | reported from       | published paper     |
|       |     |   |       |   | different           | only for both sexes |
|       |     |   |       |   | experiments;        | combined for the    |
|       |     |   |       |   |                     | species, is not     |
|       |     |   |       |   | "inactive" = no     | considered a        |
|       |     |   |       |   | TD50 or tumor site  | separate result for |
|       |     |   |       |   | listed AND more     | a "multisex"        |
|       |     |   |       |   | than one \"no       | assignment (e.g., a |
|       |     |   |       |   | positive results\"  | result listed for   |
|       |     |   |       |   | entry for           | Male Rat and Rat    |
|       |     |   |       |   | carcinogenicity     | Both Sexes would    |
|       |     |   |       |   | sex/species cells   | not be considered a |
|       |     |   |       |   | (e.g., Rat Male,    | "multisex" result   |
|       |     |   |       |   | Rat Female, etc),   | due to the          |
|       |     |   |       |   | i.e. one or more    | uncertainties in    |
|       |     |   |       |   | experiments are     | reporting.          |
|       |     |   |       |   | reported in the     |                     |
|       |     |   |       |   | CPDB, but none are  | Type of activity    |
|       |     |   |       |   | positive;           | call used by the    |
|       |     |   |       |   |                     | Food and Drug       |
|       |     |   |       |   | \"*blank*\" or null | Administration      |
|       |     |   |       |   | entry indicates     | (FDA), where        |
|       |     |   |       |   | neither condition   | greater weight is   |
|       |     |   |       |   | for multicell       | given to multisite, |
|       |     |   |       |   | activity nor        | multisex (usually   |
|       |     |   |       |   | condition for       | accompanied by      |
|       |     |   |       |   | inactivity was met. | multispecies) or    |
|       |     |   |       |   |                     | multispecies        |
|       |     |   |       |   |                     | carcinogens in      |
|       |     |   |       |   |                     | modeling and in     |
|       |     |   |       |   |                     | carcinogenicity     |
|       |     |   |       |   |                     | assessments.        |
|       |     |   |       |   |                     |                     |
|       |     |   |       |   |                     | Summary activity    |
|       |     |   |       |   |                     | call for use in     |
|       |     |   |       |   |                     | PubChem and         |
|       |     |   |       |   |                     | structure-activity  |
|       |     |   |       |   |                     | relationship        |
|       |     |   |       |   |                     | studies             |
|       |     |   |       |   |                     |                     |
|       |     |   |       |   |                     | *Field modified in  |
|       |     |   |       |   |                     | v5b for use in      |
|       |     |   |       |   |                     | PubChem, with       |
|       |     |   |       |   |                     | details provided in |
|       |     |   |       |   |                     | the text field,*    |
|       |     |   |       |   |                     | **ActivityOut       |
|       |     |   |       |   |                     | come\_\_CPDBAS_Mult |
|       |     |   |       |   |                     | iCellCall_Details** |
+-------+-----+---+-------+---+---------------------+---------------------+

+-------+-----+---+-------+---------------------+---------------------+
| *     | d   |   | mult  | Details pertaining  | *Fieldname modified |
| *Acti | efi |   | isite | to entry in         | in v5b,             |
| vityO | ned |   | ac    | **A                 | previously:*        |
| utcom | t   |   | tive, | ctivityOutcome_CPDB | **ActivityCatego    |
| e\_** | ext |   |       | AS_MultiCellCall**: | ry_MultiCellCall**. |
|       |     |   | mul   |                     |                     |
| **    |     |   | tisex | If field entry of   |                     |
| CPDBA |     |   | ac    | **                  |                     |
| S_Mul |     |   | tive, | ActivityOutcome_CPD |                     |
| tiCel |     |   |       | BAS_MultiCellCall** |                     |
| lCall |     |   | mu    | is \"active\", one  |                     |
| _Deta |     |   | ltisp | or more of the      |                     |
| ils** |     |   | ecies | following are       |                     |
|       |     |   | ac    | listed:             |                     |
| *(no  |     |   | tive/ |                     |                     |
| spa   |     |   |       | multisite active =  |                     |
| ces)* |     |   | mul   | multiple tumor      |                     |
|       |     |   | tisex | sites reported from |                     |
|       |     |   | inac  | different           |                     |
|       |     |   | tive, | experiments;        |                     |
|       |     |   |       |                     |                     |
|       |     |   | mu    | multisex active =   |                     |
|       |     |   | ltisp | male and female     |                     |
|       |     |   | ecies | sexes (possibly of  |                     |
|       |     |   | inac  | different species)  |                     |
|       |     |   | tive/ | tested positive for |                     |
|       |     |   |       | one or more tumor   |                     |
|       |     |   | *b    | sites, possibly     |                     |
|       |     |   | lank* | from different      |                     |
|       |     |   |       | experiments;        |                     |
|       |     |   |       |                     |                     |
|       |     |   |       | multispecies active |                     |
|       |     |   |       | = multiple species  |                     |
|       |     |   |       | (e.g., rat, mouse,  |                     |
|       |     |   |       | etc) tested         |                     |
|       |     |   |       | positive at one or  |                     |
|       |     |   |       | more tumor sites,   |                     |
|       |     |   |       | possibly from       |                     |
|       |     |   |       | different           |                     |
|       |     |   |       | experiments.        |                     |
|       |     |   |       |                     |                     |
|       |     |   |       | If field entry of   |                     |
|       |     |   |       | **                  |                     |
|       |     |   |       | ActivityOutcome_CPD |                     |
|       |     |   |       | BAS_MultiCellCall** |                     |
|       |     |   |       | is \"inactive\",    |                     |
|       |     |   |       | one or more of the  |                     |
|       |     |   |       | following are       |                     |
|       |     |   |       | listed:             |                     |
|       |     |   |       |                     |                     |
|       |     |   |       | multisex inactive = |                     |
|       |     |   |       | ActivityOutcome_CPD |                     |
|       |     |   |       | BAS_SingleCellCalll |                     |
|       |     |   |       | is \"0\" AND more   |                     |
|       |     |   |       | than one \"no       |                     |
|       |     |   |       | positive results\"  |                     |
|       |     |   |       | entry for male and  |                     |
|       |     |   |       | female sexes        |                     |
|       |     |   |       | (possibly of        |                     |
|       |     |   |       | different species), |                     |
|       |     |   |       | possibly from       |                     |
|       |     |   |       | different           |                     |
|       |     |   |       | experiments;        |                     |
|       |     |   |       |                     |                     |
|       |     |   |       | multispecies        |                     |
|       |     |   |       | inactive =          |                     |
|       |     |   |       | ActivityOutcome_CP  |                     |
|       |     |   |       | DBAS_SingleCellCall |                     |
|       |     |   |       | is \"0\" AND more   |                     |
|       |     |   |       | than one \"no       |                     |
|       |     |   |       | positive results\"  |                     |
|       |     |   |       | entry for multiple  |                     |
|       |     |   |       | species (e.g., rat, |                     |
|       |     |   |       | mouse, etc),        |                     |
|       |     |   |       | possibly from       |                     |
|       |     |   |       | different           |                     |
|       |     |   |       | experiments.        |                     |
|       |     |   |       |                     |                     |
|       |     |   |       | \"*blank*\" or null |                     |
|       |     |   |       | entry indicates     |                     |
|       |     |   |       | neither condition   |                     |
|       |     |   |       | for multicell       |                     |
|       |     |   |       | activity or         |                     |
|       |     |   |       | inactivity was met  |                     |
|       |     |   |       | in                  |                     |
|       |     |   |       | **A                 |                     |
|       |     |   |       | ctivityOutcome_CPDB |                     |
|       |     |   |       | AS_MultiCellCall**. |                     |
+-------+-----+---+-------+---------------------+---------------------+
| **Not | m   |   | *     | Field used to       | Single entries for  |
| e_CPD | emo |   | Text* | provide             | **TD50\_\...** and  |
| BAS** |     |   |       | supplementary       | **                  |
|       |     |   |       | Source-specific     | TargetSites\_\...** |
|       |     |   |       | information         | values for each of  |
|       |     |   |       | pertaining to the   | two species (bush   |
|       |     |   |       | chemical and        | baby and tree       |
|       |     |   |       | toxicity fields,    | shrew) were moved   |
|       |     |   |       | with text entries   | to the new          |
|       |     |   |       | to allow a user to  | **TD50_             |
|       |     |   |       | easily locate added | Dog_Primates_Note** |
|       |     |   |       | or modified records | field in v5b.       |
|       |     |   |       | in version.         |                     |
|       |     |   |       |                     | Field is            |
|       |     |   |       |                     | additionally used   |
|       |     |   |       |                     | to document any     |
|       |     |   |       |                     | additions of new    |
|       |     |   |       |                     | chemical record or  |
|       |     |   |       |                     | data modifications  |
|       |     |   |       |                     | in subsequent       |
|       |     |   |       |                     | versions of CPDBAS. |
|       |     |   |       |                     | Controlled text     |
|       |     |   |       |                     | entries include:    |
|       |     |   |       |                     |                     |
|       |     |   |       |                     | > chemical added    |
|       |     |   |       |                     | > v5a               |
|       |     |   |       |                     | >                   |
|       |     |   |       |                     | > Rat added v5a     |
|       |     |   |       |                     | >                   |
|       |     |   |       |                     | > Mouse added v5a   |
|       |     |   |       |                     | >                   |
|       |     |   |       |                     | > TD50_Rat_Note     |
|       |     |   |       |                     | > modified v5a      |
|       |     |   |       |                     | >                   |
|       |     |   |       |                     | > Mu                |
|       |     |   |       |                     | tagenicity_SAL_CPDB |
|       |     |   |       |                     | > added v5a         |
|       |     |   |       |                     | >                   |
|       |     |   |       |                     | > TD50_Rat modified |
|       |     |   |       |                     | > v5a               |
|       |     |   |       |                     | >                   |
|       |     |   |       |                     | > Targe             |
|       |     |   |       |                     | tSites_Mouse_Female |
|       |     |   |       |                     | > modified v5a      |
|       |     |   |       |                     | >                   |
|       |     |   |       |                     | > \... etc          |
|       |     |   |       |                     |                     |
|       |     |   |       |                     | CPDB-specific       |
|       |     |   |       |                     | information         |
|       |     |   |       |                     | pertaining to the   |
|       |     |   |       |                     | Source-specific     |
|       |     |   |       |                     | toxicity            |
|       |     |   |       |                     | information         |
|       |     |   |       |                     | previously included |
|       |     |   |       |                     | in **ChemicalNote** |
|       |     |   |       |                     | field has been      |
|       |     |   |       |                     | moved to this       |
|       |     |   |       |                     | field.              |
|       |     |   |       |                     |                     |
|       |     |   |       |                     | *Replaces*          |
|       |     |   |       |                     | **ToxicityNote**    |
|       |     |   |       |                     | *field (May 2007).* |
+-------+-----+---+-------+---------------------+---------------------+
| **NT  | m   |   | *     | National Toxicology | Users wishing to    |
| P\_** | emo |   | Text* | Program Technical   | extract only the    |
|       |     |   |       | Report number of    | NTP records from    |
| **Te  |     |   |       | study included in   | CPDB for modeling   |
| chnic |     |   |       | this CPDBAS record. | purposes are        |
| alRep |     |   |       |                     | cautioned that in a |
| ort** |     |   |       | Note is also        | few cases the NTP   |
|       |     |   |       | included in this    | study results       |
| *(no  |     |   |       | field if NTP study  | differ from the     |
| spa   |     |   |       | results differ from | CPDB summary call.  |
| ces)* |     |   |       | CPDB summary call   | These cases are     |
|       |     |   |       | to alert users to   | flagged in this     |
|       |     |   |       | this discrepancy.   | field.              |
|       |     |   |       | The CPDB summary    |                     |
|       |     |   |       | call can differ     |                     |
|       |     |   |       | from the NTP call   |                     |
|       |     |   |       | when additional     |                     |
|       |     |   |       | literature studies  |                     |
|       |     |   |       | meeting CPDB        |                     |
|       |     |   |       | protocol            |                     |
|       |     |   |       | requirements are    |                     |
|       |     |   |       | factored into the   |                     |
|       |     |   |       | CPDB assessment.    |                     |
+-------+-----+---+-------+---------------------+---------------------+
| **    | m   |   | *URL* | Internet URL        | URLs were           |
| Chemi | emo |   |       | website address for | previously included |
| calPa |     |   |       | chemical-specific   | in general field    |
| ge\_\ |     |   |       | data or content.    | **Website_URL**.    |
| URL** |     |   |       |                     |                     |
|       |     |   |       | URL was checked at  | *New field added    |
|       |     |   |       | time of DSSTox data | (October 2007).*    |
|       |     |   |       | file publication.   |                     |
|       |     |   |       | Please send DSSTox  |                     |
|       |     |   |       | Error Report if     |                     |
|       |     |   |       | website URL address |                     |
|       |     |   |       | no longer works or  |                     |
|       |     |   |       | is changed.         |                     |
+-------+-----+---+-------+---------------------+---------------------+
|       |     |   |       |                     |                     |
+-------+-----+---+-------+---------------------+---------------------+

**Additional CPDB references:**

A list of citations and text files to 100 papers by the Carcinogenic
Potency Project: <http://potency.berkeley.edu/listofpubs.year.html>

1\. Gold, L.S. and Zeiger, E., Eds. (1997). Handbook of Carcinogenic
Potency and Genotoxicity Databases. Boca Raton, FL: CRC Press.
<http://potency.berkeley.edu/CRCbook.html>

2\. Gold, L.S., T.H. Slone, and B. Ames (1999) Summary of Carcinogenic
Potency Database by Chemical.
<http://potency.berkeley.edu/chemicalsummary.html>

3\. Gold, L.S., N.B. Manley, T.H. Slone, and J.M. Ward (2001) Compendium
of chemical carcinogens by target organ: Results of chronic bioassays in
rats, mice, hamsters, dogs and monkeys. *Toxicol. Pathol.* 29: 639-652.
<http://potency.berkeley.edu/text/ToxicolPathol.pdf>

4\. Zeiger, E. (1997) Genotoxicity Database. In: Gold, L.S., and Zeiger,
E., Eds. Handbook of Carcinogenic Potency and Genotoxicity Databases.
Boca Raton, FL: CRC Press, pp. 687-729.
<http://potency.berkeley.edu/CRCbook.html>

5\. Kier, L.E., D.J. Brusick., A.E. Auletta, E.S. Von Halle, M.M. Brown,
V.F. Simmon, V. Dunkel, J. McCann, K. Mortelmans, M. Prival, T.K. Rao,
and V. Ray (1986) The *Salmonella typhimurium*/mammalian microsomal
assay: A report of the U.S. Environmental Protection Agency Gene-Tox
Program. *Mutat. Res.* 168: 69-240.

6\. Auletta, A.E., Personal communication (with L.S.Gold).

7\. Peto, R., M.C. Pike, L. Bernstein, L.S. Gold, and B.N. Ames (1984)
The TD~50~: A proposed general convention for the numerical description
of the carcinogenic potency of chemicals in chronic-exposure animal
experiments. *Environ. Health Perspect.* 58: 1-8.

8\. Sawyer, C., R. Peto, L. Bernstein, and M.C. Pike (1984) Calculation
of carcinogenic potency from long-term animal carcinogenesis
experiments. *Biometrics* 40: 27-40.

9\. Gold, L.S., T.H. Slone, and L. Bernstein (1989) Summary of
carcinogenic potency (TD~50~) and positivity for 492 rodent carcinogens
in the Carcinogenic Potency Database. *Environ. Health Perspect.* 79:
259-272.