Number range CHAPTERMay 2007

[CURRICULUM VITAE]{.underline}

[Name:]{.underline} Daniel W. McVicar

[Date and Place of Birth:]{.underline} September 19, 1963; Leesburg, VA

[Citizenship:]{.underline} United States

[Marital Status:]{.underline} Married; three children

[Education:]{.underline}

> 1985 B.S., State University of New York at Oneonta, NY
>
> 1990 Ph.D., Virginia Commonwealth University, Medical College of
> Virginia, Richmond, VA. \"Differential Effects of Corticosteroids and
> Glioma on Cellular Cytotoxicity and T Lymphocyte Activation\".

[Employment:]{.underline}

> 1986-1990 Pre-Doctoral Fellow, Virginia Commonwealth University,
>
> Medical College of Virginia, Richmond, VA
>
> 1990-1995 IRTA Research Fellow, Laboratory of Experimental Immunology,
> Biological Response Modifiers Program, Division of Cancer Treatment,
> National Cancer Institute, Frederick, MD
>
> 1995-1998 Senior Staff Fellow, Laboratory of Experimental Immunology,
> Division of Basic Sciences, National Cancer Institute, Frederick, MD
>
> 1998-Date Principal Investigator, Laboratory of Experimental
> Immunology, Center for Cancer Research, National Cancer Institute,
> Frederick, MD

[Teaching Experience]{.underline}:

> Spring 1985 Undergraduate Laboratory Teaching Assistant, New York
> State University, College at Oneonta, Department of Chemistry,
> Instrumental Analysis (Class Size 24)
>
> Fall 1985 Graduate Laboratory Teaching Assistant, Long Island
> University, C.W. Post Center, Department of Biology, General Biology
>
> (Class Size 30)
>
> Fall 1986 Graduate Laboratory Teaching Assistant, Medical College of
> Virginia, Department of Anatomy, Medical Gross Anatomy (Class Size
> 165)
>
> Fall 1987 Graduate Teaching Assistant, Medical College of Virginia,
> Department of Anatomy, Pharmacy Anatomy (Class Size 165)

Fall 1988 Graduate Laboratory Teaching Assistant, Medical College of
Virginia, Department of Anatomy, Medical Histology (Class Size 165)

[Editorial Boards:]{.underline}

Journal of Biological Chemistry (2006-2009)

[Ad Hoc Reviewer]{.underline}:

Journal of Biological Chemistry

> Journal of the National Cancer Institute
>
> Journal of Leukocyte Biology
>
> Journal of Immunology
>
> Biochemica et Biophysica Acta
>
> Journal of Biological Chemistry, Immunology, Immunity
>
> Molecular Immunology

[Honors and Other Special Scientific Recognition:]{.underline}

> 2002 National Cancer Institute, Mentor of Merit Award
>
> 2002 Invited Chair, 2002 Keystone Symposium "Immune Receptors"
>
> 2004 National Cancer Institute, Outstanding Mentor Award
>
> 2004 NIH Intramural AIDS Targeted Antiviral Program Award
>
> (\$80,500 direct costs)

[Committees, Boards, & Interest Groups:]{.underline}

> Summer 1998 National Cancer Institute-Intramural Advisory Board
> (NCI-IAB) Working Group on Post-Doctoral Fellow Recruitment. A panel
> charged with examining issues that affect Post-Doctoral Recruitment at
> the level of the Institute, and report to the full NCI-IAB.
>
> October 1998-2000 National Cancer Institute-Intramural Advisory Board
> (NCI-IAB). A panel of 17 selected intramural scientists that address
> all issues related to the NCI intramural program and report directly
> to the Director of the National Cancer Institute.

September 1998-

> August 2000 Coordinator, NCI-FCRDC Immunology and Cell Biology Seminar
> Series. A facility-wide weekly seminar series.

June 2001 Ad Hoc ALY Study Section Panelist, National Institute of
Allergy and Infectious Disease (Arthur Weiss, Chairman).

October 2000-

> September 2002 Elected Member, NIH Immunology Interest Group, Steering
> Committee. (This committee coordinates the NIH wide seminar series and
> off campus NIH Immunology Retreat.)
>
> September 2002 Invited Panelist, National Cancer Institute Mentoring
> Workshop.
>
> April 2003 Invited Panelist, National Cancer Institute-Frederick
> Mentoring Workshop.
>
> June 2003 Ad Hoc ALY Study Section Panelist, National Institute of
> Allergy and Infectious Disease (Carl Ware, Chairman).
>
> November 2003 Ad Hoc Special Emphasis Panel Study Section Panelist
>
> (Gerald Nepom, Chairman).
>
> February 2004 Ad Hoc ALY Study Section Panelist, National Institute of
> Allergy
>
> and Infectious Disease (Carl Ware, Chairman).
>
> June 2004 Ad Hoc CMI-A Study Section Panelist, Center for Scientific
> Review, NIH (Carl Ware, Chairman).
>
> 2005 Invited Panelist, National Cancer Institute Young Investigators
> Retreat, Guide to Mentoring
>
> 2005 -- Present National Cancer Institute, Institutional Biosafety
> Committee. (This committee oversees all Biosafety issues relating to
> recombinant DNA, toxin use, and chemical hazards for all of NCI.)

[Research Interests]{.underline}: Molecular and Cellular Immunology,
Biochemistry, and Signal Transduction within Immune Effector Cells.

[Patents]{.underline}:

US Patent #E08/373,934 dated 1/13/95.

Janus Kinases and Identification of Immune Modulators.

> US Provisional Paten#10/802,441, dated 3/17/03.
>
> TLT-1 A Novel Inhibitory Receptor and Uses Therefore

[Invited Talks]{.underline}:

> April 1995 "Protein tyrosine phosphorylation and the expression of
> tyrosine kinases as biochemical correlates of lymphocyte subset
> formation." Medical College of Virginia Alumni Association, 37th
> Annual Scientific Assembly
>
> January 1996 "Chk, a Csk homologous kinase, expressed in natural
> killer cells and activated T cells." National Institute of Allergy and
> Infectious Diseases, National Institutes of Health, Twinbrook II
> Seminar Series, Bethesda, MD
>
> Spring 1996 Invited Lecturer, "Cell Activation: from the Membrane In."
> Shenandoah University School of Pharmacy (Class Size 72)
>
> February 1997 "Novel protein tyrosine kinases from natural killer
> cells: Preliminary characterization of a Csk homologous kinase, Chk."
> Uniformed Services University of the Health Sciences, Molecular and
> Cell Biology Seminar Series, Bethesda, MD
>
> October 1998 "DAP12-mediated Signal Transduction: A Dominant Role for
> the Syk Protein Tyrosine Kinase." Fifth Annual Meeting of the Society
> for Natural Immunity
>
> October 1998 "Signal Transduction by the Novel Signal Transduction
> chain, DAP12." National Institutes of Health Immunology Retreat
>
> Spring 1998 --
>
> Spring 2001 Invited Lecturer, "Positive and Negative Signaling
> Receptors: The Yin & Yang of Signal Transduction." George Mason
> University
>
> May 1999 "Biochemistry of the Inhibition and Activation Mediated by
> the Ly49 Proteins: A Story of Yin, Yang Yin?" Indiana University
> School of Medicine
>
> January 2000 "Signaling by Paired Inhibitory Receptors." Microbiology
> and Immunology Seminar Series, Medical College of Virginia, Richmond,
> VA
>
> Fall 2000 Invited Lecturer, "Signal Transduction in NK Cells." Medical
> College of Virginia, Richmond, VA
>
> September 2001 FDA, Division of Therapeutic Proteins Seminar Series
>
> September 2001 Invited Speaker, Queen's University, Belfast Northern
> Ireland,
>
> Department of Immunology

September 2001 Keynote Speaker, Northern Ireland Cancer Center and
Queen's

> University Combined Immunology Retreat, Coleraine,
>
> Northern Ireland
>
> March 2002 Workshop Chairman & Invited Speaker, "Molecular and
> Cellular Biology and Leukocyte Regulatory Receptors." Keystone
> Symposia
>
> December 2002 "Identification and Signaling of Paired Receptor."
> University of Virginia, Charlottesville, Beirne B. Carter Immunology
> Seminar Series
>
> January 2003 National Cancer Institute, Immunology Faculty Seminar
>
> September 2003 "Paired Immune Regulatory Receptors: From NK Cells and
> into the Myeloid Compartment." Fred Hutchinson Cancer Research Center,
> Seattle, WA
>
> April 2004 "Inhibitory Receptors, Platelets and Beyond." Dept of
> Immunology, Queen\'s University, Belfast, Northern Ireland
>
> April 2004 Study Section Panelist, Science Foundation Ireland,
> Belfast, Northern Ireland.
>
> November 2004 "The TREM Family of Receptors Regulators of Monocytes
> and Platelets." FDA

2005. Invited Speaker, FASEB Summer Research Conference, Signal
      Transduction in the Immune System, Snowmass, CO

> 2005 Invited Speaker, Introduction to Cancer Research Careers for
> Underrepresented Minorities, State of Cancer Research Lecture,
> Bethesda, MD

2006. Invited Chair and Speaker, Society for Natural Immunity Guest,
      American Association of Immunologist, Boston, MA

[Present Home Address]{.underline}: 28 Sunlite Drive

> Charles Town, WV 25414

[BIBLIOGRAPHY]{.underline}

1\. Merchant, R.E., Merchant, L.H., Cook, S.H.S., McVicar, D.W., and
Young, H.F.: Intralesional infusion of lymphokine-activated killer (LAK)
cells and recombinant interleukin-2 (rIL-2) for the treatment of
patients with malignant brain tumor. [Neurosurgery]{.underline} 23:
725-732, 1988.

2\. McVicar, D.W., Merchant, R.E., Merchant, L.H., and Young, H.F.:
Corticosteroids inhibit the generation of lymphokine- activated killer
(LAK) activity *in vitro*. [Cancer Immunol. Immunother.]{.underline} 29:
211-218, 1989.

3\. McVicar, D.W., Li, F., McCrady, C., and Merchant, R.E.: A comparison
of serum-free media for the support of *in vitro* mitogen-induced
blastogenic expansion of cytolytic lymphocytes.
[Cytotechnology]{.underline} 6: 105-133, 1991.

4\. McVicar, D.W., Davis, D.F., and Merchant, R.E..: *In vitro* analysis
of the proliferative potential of T cells from patients with brain
tumor: glioma-associated immunosuppression unrelated to intrinsic
cellular defect. [J. Neurosurg.]{.underline} 76: 251-260, 1992.

5\. McVicar, D.W., McCrady, C.W., and Merchant, R.E.: Corticosteroids
inhibit the delivery of short-term activational pulses of phorbol ester
and calcium ionophore to human peripheral T cells. [Cell.
Immunol.]{.underline} 140: 145-157, 1992.

6\. Merchant, R.E., McVicar, D.W., Merchant, L.H., and Young, H.F.:
Treatment of recurrent malignant glioma by repeated intracerebral
injections of human recombinant interleukin-2 alone or in combination
with systemic interferon. Results of a phase I clinical trial. [J.
Neuro-Oncol.]{.underline} 12: 75-83, 1992.

7\. O\'Shea, J.J., McVicar, D.W., Kuhns, D.B., and Ortaldo, J.R.: A role
for protein tyrosine kinase activity in natural cytotoxicity as well as
antibody-dependent cellular cytotoxicity; Effects of herbimycin A. [J.
Immunol.]{.underline} 148: 2497-2502, 1992.

8\. Mizoguchi, H., O\'Shea, J.J., Longo, D.L., Loeffler, C.M., McVicar,
D., and Ochoa, A.C.: Alterations in signal transduction molecules in T
lymphocytes from tumor-bearing mice. [Science]{.underline} 258:
1795-1798, 1992.

9\. Kelvin, D.J., Wang, J.M., McVicar, D.W., and Oppenheim, J.J.:
Promiscuity of ligand binding in the chemokine  receptor family. [Adv.
Exp. Med. Biol.]{.underline} 351: 147-153, 1993.

10\. O\'Shea, J.J, McVicar, D.W., Bailey, T.L., Burns, C., and Smyth,
M.J.: Activation of human peripheral blood T lymphocytes by
pharmacological induction of protein-tyrosine phosphorylation. [Proc.
Natl. Acad. Sci. USA]{.underline} 89: 10306-10310, 1992.

11\. Wang, J.M., McVicar, D.W., Oppenheim, J.J., and Kelvin, D.J.:
Identification of Rantes receptors on human monocytic cells: competition
for binding and desensitization by homologous chemotactic cytokines. [J.
Exp. Med.]{.underline} 177: 699-705, 1993.

12\. Norihisa, Y., McVicar, D.W., Ghosh, P., Houghton, A.N., Longo,
D.L., Creekmore, S.P., Ortaldo, J.R., and Young, H.A.: Increased
proliferation, cytotoxicity, and gene expression after stimulation of
human peripheral blood T lymphocytes through surface ganglioside (GD3).
[J. Immunol.]{.underline} 152: 485-495, 1994.

13\. McVicar, D.W., Mason, A.T., Bere, E.W., and Ortaldo, J.R.:
Activation of peripheral large granular lymphocytes by the
serine/threonine phosphatase inhibitor, okadaic acid. [Eur. J.
Immunol.]{.underline} 24: 165-170, 1994.

14\. Kawamura, M., McVicar, D.W., Johnston, J.A., Blake, T.B., Chen,
Y-Q., Lal, B.K., Lloyd, A.R., Kelvin, D.I., Staples, J.E., Ortaldo,
J.R., and O\'Shea, J.J.: Molecular cloning of L-JAK, a Janus family
protein tyrosine kinase expressed in natural killer cells and activated
leukocytes. [Proc. Natl. Acad. Sci. USA.]{.underline} 91: 6374-6378,
1994.

15\. McVicar, D.W., Lal, B.K., Lloyd, A., Kawamura, M., Chen, Y-Q.,
Zhang, X., Staples, J.E., Ortaldo, J.R., and O\'Shea, J.J.: Molecular
cloning of Lsk, a carboxyl-terminal *src* kinase (*csk*) related gene,
expressed in leukocytes. [Oncogene]{.underline} 9: 2037-2044, 1994.

16\. Murphy, W.J., Durum, S.K., Anver, M.R., Ferris, D.K., McVicar,
D.W., O\'Shea, J.J., Ruscetti, S.K., Smith, M.R., Young, H.A., and
Longo, D.L.: Induction of T cell differentiation and lymphomagenesis in
the thymus of mice with severe combined immune deficiency (SCID). [J.
Immunol.]{.underline} 153: 1004-1014, 1994.

17\. Johnston, J.A., Kawamura, M., Kirken, R.A., Chen, Y-Q., Blake,
T.B., Shibuya, K., Ortaldo, J.R., McVicar, D.W., and O\'Shea, J.J.:
Phosphorylation and activation of the JAK-3 Janus kinase in response to
interleukin-2. [Nature]{.underline} 370: 151-153, 1994.

18\. Musso, T., Varesio, L., Zhang, X., Rowe, T.K., Ortaldo, J.R.,
O\'Shea, J.J., and McVicar, D.W.: IL-4 and IL-13 induce Lsk, a Csk-like
tyrosine kinase, in human monocytes. [J. Exp. Med.]{.underline} 180:
2383-2388, 1994.

19\. Russell, S.M., Johnston, J.A. Noguchi, M., Kawamura, M., Bacon,
C.M., Friedmann, M., Berg, M., McVicar, D.W., Witthuhn, B.A.,
Silvennoinen, O., Goldman, A.S., Schmalstieg, F.C., Ihle, J.N., O\'Shea,
J.J., and Leonard, W.J.: Interaction of IL-2R and c chains with JAK1
and JAK3: implications for XSCID and XCID. [Science]{.underline} 266:
1042-1045, 1994.

20\. Bacon, C.M., McVicar, D.W., Ortaldo, J.R., Rees, R.C., O\'Shea,
J.J., and Johnston, J.A.: Interleukin-12 (IL-12) induces tyrosine
phosphorylation of JAK2 and TYK2: differential use of Janus tyrosine
kinases by IL-2 and IL-12. [J. Exp. Med.]{.underline} 181: 399-404,
1995.

21\. Musso, T., Johnston, J.A., Linnekin, D., Varesio, L., Rowe, T.K.,
O\'Shea, J.J., and McVicar, D.W.: Regulation of JAK3 expression in human
monocytes: phosphorylation in response to interleukins 2, 4, and 7. [J.
Exp. Med.]{.underline} 181: 1425-1431, 1995.

22\. Mason, A.T., McVicar, D.W., Smith, C.A., Young, H.A., Ware, C.A.,
and Ortaldo, J.R.: Regulation of NK cells through the 80 kDa-TNF
receptor (CD120b). [J. Leukoc. Biol.]{.underline} 58: 249-255, 1995.

23\. Tortolani, P.J., Lal, B.K., Riva, A., Johnston, J.A., Chen, Y-Q.,
Reaman, G.H., Beckwith, M., Longo, D., Ortaldo, J.R., Bhatia, K.,
McGrath, I., Kehrl, J., Tuscano, J., McVicar, D.W., and O\'Shea, J.J.:
Regulation of JAK3 expression and activation in human B cells and
malignancies. [J. Immunol.]{.underline} 155: 5220-5226, 1995.

24\. Tortolani, P.J., Johnston, J.A., Bacon, C.M., McVicar, D.M.,
Shimosaka, A., Linnekin, D., Longo, D.L., and O\'Shea, J.J.:
Thrombopoietin induces tyrosine phosphorylation and activation of the
Janus kinase, JAK-2. [Blood]{.underline} 15: 3444-3451, 1995.

25\. Xu, L.L., McVicar, D.W., Ben-Baruch, A., Kuhns, D.B., Johnston, J.,
Oppenheim, J.J., and Wang, J.M.: Monocyte chemotactic protein-3 (MCP3)
interacts with multiple leukocyte receptors: binding and signaling of
MCP3 through shared as well as unique receptors on monocytes and
neutrophils. [Eur. J. Immunol]{.underline} 25: 2612-2617, 1995.

26\. Badolato, R., Johnston, J.A., Wang, J.M., McVicar, D., Xu, L.L.,
Oppenheim, J.J., and Kelvin, D.J.: Serum amyloid a induces calcium
mobilization and chemotaxis of human monocytes by activating a pertussis
toxin-sensitive signaling pathway. [J. Immunol.]{.underline} 155:
4004-4010, 1995.

27\. McVicar, D.W., Blake, T.B., Burns, C.M., Conlon, K.C., Ortaldo,
J.R., and O\'Shea, J.J.: Differential basal protein tyrosine
phosphorylation in natural killer (NK) and T cells: a biochemical
correlate of lymphoid functional activity. [Cell. Immunol.]{.underline}
169: 302-308, 1996.

28\. Sayers, T.J., Lloyd, A.R., McVicar, D.W., O\'Connors, M.D., Kelly,
J.M., Carter, C.R.D., Wiltrout, T.A., Wiltrout, R.A., and Smyth, M.J.:
Cloning and expression of a second human natural killer cell granule
tryptase, HNK-Tryp-2/granzyme 3. [J. Leukoc. Biol.]{.underline} 69:
763-768, 1996.

29\. Ortaldo, J.R., Mason, A.T., Longo, D.L., Beckwith, M., Creekmore,
S.P., and McVicar, D.W.: T cell activation via the disialoganglioside,
GD3: analysis of signal transduction. [J. Leukoc. Biol.]{.underline} 60:
533-539, 1996.

30\. Grgurevich, S., Linnekin, D., Musso, T., Zhang, X., Modi, W.,
Varesio, L., Ruscetti, F.W., Ortaldo, J.R., and McVicar, D.W.: The
Csk-like proteins Lsk, Hyl, and Matk represent the same
[C]{.underline}sk [h]{.underline}omologous [k]{.underline}inase (Chk)
and are regulated by stem cell factor in the megakaryoblastic cell line
MO7e. [Growth Factors]{.underline} 14: 103-115, 1997.

31\. Mason, L.H., Gosselin, P., Anderson, S.K., Fogler, W.E., Ortaldo,
J.R., and McVicar, D.W.: Differential tyrosine phosphorylation of
inhibitory versus activating Ly-49 receptor proteins and their
recruitment of SHP-1 phosphatase. [J. Immunol.]{.underline} 159:
4187-4196, 1997.

32. Mason, L.H., Willette-Brown, J., Anderson, S.K., Gosselin, P.,
    Shores, E.W., Love, P.E., Ortaldo, J.R., and McVicar, D.W.: Cutting
    Edge: Characterization of an associated 16-kDa tyrosine
    phosphoprotein required for Ly-49D signal transduction. [J.
    Immunol.]{.underline} 160: 4148-4152, 1998.

33. McVicar, D.W., Taylor, L.S., Gosselin, P., Willette-Brown, J.,
    Mikhael, A.I., Nakamura, M.C., Linnemeyer, P., Seaman, W.E.,
    Anderson, S.K., Ortaldo, J.R., and Mason, L.H.: DAP 12-mediated
    signal transduction in natural killer cells: a dominant role for the
    Syk protein tyrosine kinase. [J. Biol. Chem.]{.underline} 273:
    32934-32942, 1998.

34. Ortaldo, J.R. and McVicar, D.W.: Murine NK receptors: Ly-49
    expression, function and intracellular signaling. In: [Cytotoxic
    Cells: Basic Mechanisms and Medical Applications,]{.underline}
    Sitkovsky, M.V. and Henkart, P.A. (Eds), Lippincott Williams &
    Wilkins, Philadelphia, PA, 1999, pp. 45-63.

35. Gosselin, P., Mason, L.H., Willette-Brown, J., Ortaldo, J.R.,
    McVicar, D.W., and Anderson, S.K.: Induction of DAP12
    phosphorylation, calcium mobilization, and cytokine secretion by
    Ly49H. [J. Leukoc. Biol.]{.underline} 66: 165-171, 1999.

36. Grgurevich, S., Mikhael, A., and McVicar, D.W.: The Csk homologous
    kinase, Chk, binds tyrosine phosphorylated paxillin in human blastic
    T cells. [Biochem. Biophy. Res. Commun.]{.underline} 256: 668-675,
    1999.

37. Schaeffer, E.M., Debnath, J., Yap, G., McVicar, D., Liao, C.,
    Littman, D.R., Sher, A., Varmus, H.E., Lenardo, M.J., and
    Schwartzberg, P.L.: Requirement for the tec kinases Rlk and Itk in T
    cell receptor signaling and immunity. [Science]{.underline} 284:
    638-641, 1999.

38. Taylor, L.S. and McVicar, D.W.: Functional association of FcRI
    with Arginine^632^ of paired immunoglobulin receptor (PIR)-A3 in
    murine macrophages. [Blood]{.underline} 94: 1790-1796, 1999.

39. Makriannis, A.P., Gosselin, P., Mason, L.H., Taylor, L.S., McVicar,
    D.W., Ortaldo, J.R., and Anderson, S.K.: Cloning and
    characterization of a novel activating Ly49 closely related to
    Ly49A. [J. Immunol.]{.underline} 163: 4931-4938, 1999.

40. Ortaldo, J.R., Winkler-Pickett, R., Willette-Brown, J., Wange, R.L.,
    Anderson, S.K., Palumbo, G.J., Mason, L.H., and McVicar, D.:
    Structure/function relationship of activating Ly-49D and inhibitory
    Ly-49G2 NK receptors. [J. Immunol.]{.underline} 163: 5269-5277,
    1999.

41. Mason, L.H., Willette-Brown, J., Mason, A.T., McVicar, D., and
    Ortaldo, J.R.: Interaction of Ly-49D^+^ NK cells with H-2D^d^ target
    cells leads to DAP-12 phosphorylation and IFN- secretion. [J.
    Immunol.]{.underline} 164: 603-611, 2000.

42. Taylor, G.A., Collazo, C.M., Yap, G.S., Nguyer, K., Gregorio, T.A.,
    Taylor, L.S., Eagleson, B., Secrest, L., Southen, E.A., Reid, S.W.,
    Tessarollo, L., Bray, M., McVicar, D.W., Komschlies, K.L., Young,
    H.A., Biron, C.A., Sher, A., and VandeWoude, G.F.: Pathogen-specific
    loss of host resistance in mice lacking the interferon--inducible
    gene IGTP. [Proc. Natl. Acad. Sci. USA]{.underline} 97: 751-755,
    2000.

43. Paul, S.P., Taylor, L.S., Stansbury, E.K., and McVicar, D.W.:
    Myeloid specific human CD33 is an inhibitory receptor whose ITIM
    function in recruiting the phosphatases SHP-1 and SHP-2.
    [Blood]{.underline} 96: 483-490, 2000.

44. Taylor, L.S., Paul, S.P., and McVicar, D.W.: Paired inhibitory and
    activating receptor signals. [Rev. in Immunogenetics]{.underline} 2:
    204-219, 2000.

45. Schaeffer, E.M., Broussard, C., Debnath, J., Anderson, S., McVicar,
    D.W., and Schwartzberg, P.L.: Tec family kinases modulate thresholds
    for thymocyte development and selection. [J. Exp. Med.]{.underline}
    192: 987-1000, 2000.

46. McVicar, D.W., and Burshtyn, D.N.: Intracellular signaling by the
    killer immunoglobulin-like receptors (KIR) and Ly49. [Sci.
    STKE]{.underline} (Signal Transduction Knowledge Environment)
    Review, 2001.

47. Anderson, S.K., Ortaldo, J.R., and McVicar, D.W.: The ever-expanding
    Ly49 gene family; repertoire and signaling. [Immunol.
    Rev.]{.underline} 181: 79-89, 2001.

48. Schaeffer, E., Yap, G., Lewis, C.M., Czar, M., McVicar, D.W., Sher,
    A., and Schwartzberger, P.L.: Mutation of Tec family kinases alters
    T helper cell differentiation. [Nature Immunol.]{.underline} 2:
    1183-1188, 2001.

49. Makrigiannis, A.P., Pau, A.T., Schwartzberg, P.L., McVicar, D.W.,
    Beck, T.W., and Anderson, S.K.: A BAC contig map of the Ly49 gene
    cluster in 129 mice reveals extensive differences in gene content
    related to C57BL/6 mice. [Genomics]{.underline} 79: 437-444, 2002.

50. McVicar, D.W. Winkler-Pickett, R., Taylor, L.S., Makrigiannis, A.,
    Bennett, M., Anderson, S.K., and Ortaldo, J.R.: Aberrant Dap12
    signaling in the 129 strains of mice: implications for the analysis
    of gene targeted mice. [J. Immunol.]{.underline} 169: 1721-1728,
    2002.

51. Washington, A.V., Quigley, L., and McVicar, D.W.: Initial
    characterization of TREM-like transcript (TLT)-1: An inhibitory
    receptor within the TREM cluster. [Blood]{.underline} 100:
    3822-3824, 2002.

52. Washington, A.V. and McVicar, D.W.: Receptors involved in the
    regulation of murine NK cells. [Current Protocol in
    Immunology]{.underline} A.1R.1-A.1R.8, 2002.

53. McFarland, H.I., Hansal, S.A., Morris, D.I., McVicar, D.W., Love,
    P.E., and Rosenberg, A.S.: Signaling through MHC in transgenic mice
    generates a population of memory phenotype cytolytic cells that lack
    TCR. [Blood]{.underline} 101: 4520-4527, 2003.

54. Washington, A.V. and McVicar, D.W.: Receptors documented on murine
    NK cells. [BioMedical PDA]{.underline}, Version 2, on Current
    Protocols Website, 2003.

55. Haan, S., Ferguson, P., Sommer, U, Hiremath, M, McVicar, D.,
    Heinrick, P.C., Johnston, J.A. and Cacalano, N.A.: Tyrosine
    phosphorylation disrupts elongin interaction and accelerates SOCS3
    degradation. [J. Biol. Chem.]{.underline} 278: 31972-31979, 2003.

56. Washington, A.V., Schubert, R.L., Quigley, L., Disipio, T., Feltz,
    R., Cho, E.H., and McVicar, D.W.: TREM family member, TLT-1, is
    found exclusively in the -granules of megakaryocytes and platelets.
    [Blood]{.underline} 104: 1042-1047, 2004.

57. Hiremath, M.M., Mikhael, A.I., Taylor, L.S., Musso, T., and McVicar,
    D.W.: Complex regulation of the Csk homologous kinase (Chk) by IL-4
    family cytokines and IFN in human peripheral blood monocytes. [Mol.
    Immunol]{.underline}. 41: 901-910, 2004.

58\. Makrigiannis, A.P., McVicar, D.W., and Anderson, S.K.: Ly49D.
AfCS-Nature Molecule Pages. (Doi:10.1038/mp.a001423.01), 2005.

59\. Mason, L.H., Willette-Brown, J., Taylor, L.S., and McVicar, D.W.:
Regulation of Ly49D/DAP12 signal transduction by Src-family kinases and
CD45. [J. Immunol.]{.underline} 176: 6615-6623, 2006.

60. Gattis, J.L., Washington, A.V., Chisolm, M., Quigley, L., Szyk, A.,
    McVicar, D.W., and Lubkowski, J.: The structure of the extracellular
    domain of triggering receptor expressed on myeloid cells like
    transcript-1, and evidence for a naturally occurring soluble
    fragment. [J. Biol. Chem.]{.underline} 281: 13396-13403, 2006.

61\. Bashirova, A.A., Martin, M.P., McVicar, D.W., and Carrington, M.:
The killer immunoglobulin-like receptor gene cluster: tuning the genome
for defense. [Ann. Rev. Genomics Hum. Genet.]{.underline} 7: 277-300,
2006.

62\. Thananchai, H., Gillespie, G., Martin, M.P., Bashirova, A., Yawata,
N., Yawata, M., Easterbrook, P., McVicar, D.W., Maenaka, K., Parham, P.,
Carrington, M., Dong, T., and Rowland-Jones, S.: Cutting Edge:
Allele-specific and peptide-dependent interactions between KIR3DL1 and
HLA-A and HLA-B. [J. Immunol]{.underline}. 178: 33-37, 2007.

63\. Orr, S.J., Morgan, N.M., Elliott, J., Burrows, J., Scott, C.J.,
McVicar, D.W. and Johnston, J.A.: CD33 responses are blocked by SOCS3
through accelerated proteasomal-mediated turnover. [Blood]{.underline}
109: 1061-1068, 2007.

[IN PRESS]{.underline}

1.Number range CHAPTER Gillespie, G.M.A., Bashirova, A., Dong, T.,
McVicar, D.W., Rowland-Jones, S.L., and Carrington, M.: Lack of KIR3DS1
binding to MHC class I Bw4 tetramers in complex with HIV-1-derived T
cell epitopes. [AIDS Res. Hum. Retroviruses]{.underline}, 2007.

2\. Whittaker, G.C., Anderson, SK., and McVicar, D.W.: DAP12.
[AfCS-Nature Molecular Pages]{.underline}, 2007.

3.  Giomarelli, B., Washington, A.V., Chisholm, M., Quigley, L.,
    McMahon, J.R., Mori, T., and McVicar, D.W.: Inhibition of thrombin
    induced platelet aggregation by human single chain Fv antibodies
    specific for TREM-like transcript-1. [Thrombosis &
    Haemostasis]{.underline}, 2007[.]{.underline}

4.  Number range CHAPTERPascal, V., Yamada, E., Martin, M.P., Alter, G.,
    Altfeld, M., Metcalf, J.A., Baseler, M.W., Adelsberger, J.W.,
    Carrington, M., Anderson, S.K., and McVicar, D.W.: Detection of
    KIR3DS1 on the cell surface of peripheral blood NK cells facilitates
    identification of a novel null allele and assessment of KIR3DS1
    expression during HIV-1 infection. [J. Immunol]{.underline}., in
    press.

5.  Pascal, V., Abshari, M., Siebenlist, U., Anderson, S.K.: NF-κFB
    p50/p65 affects the frequency of Ly49 gene expression by natural
    killer cells. [J. Immunol]{.underline}., in press.

[SUBMITTED]{.underline}

1\. Number range CHAPTERMartin, M.P, Qi, Y., Gao, X., Brown, E.E.,
Phaie, J., Goedert, J.J., Buchbinder, S., Kirk, G.D., O'Brien, S.J.,
Parham, P., McVicar, D.W., and Carrington, M.: Innate partnership of
HLA-B and KIR3DL1 subtypes against HIV-1. [Submitted to Nature Genetics,
8/2006, presently in revision]{.underline}.