Number range CHAPTER

[CURRICULUM VITAE]{.underline}

[Name]{.underline}: Kathrin Muegge

[Citizenship]{.underline}: German, (US Permanent Resident)

[Education]{.underline}:

> 1967-1971 Elementary School, Uelzen, Germany

1971-1980 Herzog-Ernst Gymnasium, Abitur mark 1.0, Uelzen, Germany

> 1980-1986 M.D., magna cum laude, Hannover Medical School, Hannover,
> Germany

1987 Certificate of the Educational Commission for Foreign Medical
Graduates

[Brief Chronology of Employment]{.underline}:

2004-present Senior Principal Investigator, Laboratory of Cancer
Prevention, SAIC, National Cancer Institute, Center for Cancer Research,
Frederick, MD

1996-2004 Senior Principal Investigator, Laboratory of Molecular
Immunoregulation, SAIC, National Cancer Institute, Center for Cancer
Research, Frederick, MD

1990-1996 Senior Scientist, Laboratory of Molecular Immunoregulation,
SAIC, National Cancer Institute, Center for Cancer Research, Frederick,
MD

> 1987-1989 Guest Researcher, Laboratory of Molecular Immunoregulation,
> Biological Response Modifiers Program, National Cancer Institute,
> Frederick, MD

[Societies]{.underline}:

> The American Association of Immunologists
>
> The International Cytokine Society

The International Cytokine and Interferon Society

[Honors and Other Special Scientific Recognition]{.underline}:

2003 Extension of NCI Intramural Research Award

2001 National Cancer Institute, Intramural Research Award

1994 Editorial Board of Cellular Immunology

1994 Outstanding Performance Award, SAIC, NCI-Frederick Cancer Research
and Development Center

1991 Outstanding Performance Award, SAIC, NCI-Frederick Cancer Research
and Development Center

1987 Scholarship of the German Research Society (DFG)

[Research Interest]{.underline}: Epigenetic modifications of chromatin

# Publications

1\. Tartakovsky, B., Finnegan, A., Muegge, K., Brody, D. T., Kovacs, E.
J., Smith, M. R., Berzofsky, J. A.,Young, H. A., and Durum, S. K.:
Interleukin-1 is an autocrine growth factor for T cell-clones. [J.
Immunol]{.underline}. 141: 3863-3867, 1987.

2\. Stoeck, M., Muegge, K., and Resch, K.: Induction of responsiveness
to IL-2 production in ConA-stimulated rat lymphoid cells requires
synergistic action of IL-1 and the accessory cell membrane.
[Immunobiol]{.underline}. 177: 460-464, 1988.

3\. Ozaki, S., Durum, S. K., Muegge, K., York-Jolley, J., and Berzofsky,
J. A.: Production of T-T hybrids from T cell clones. Direct comparison
between cloned T cells and T cell hybridomas derived from them. [J.
Immunol]{.underline}. 141: 71-78, 1988.

4\. Harel-Bellan, A., Durum, S. K., Muegge, K., Abbas, A. K., and
Farrar, W. L.: Specific inhibition of lymphokine biosynthesis and
autocrine growth using antisense oligonucleotides in Th1 and Th2 helper
T cell clones. [J. Exp. Med]{.underline}. 168: 2309-2318, 1988.

5\. Muegge, K. and Durum, S. K.: The role of IL-1 in the immune
response. In Bomford, R.H.R. and Henderson, B. (Eds.): [Interleukin 1,
Inflammation and Disease]{.underline}. New York, Elsevier, 1989, pp.
107-122.

6\. Muegge, K. and Durum, S. K.: Cytokines and nuclear factors: Cell
code to gene code. [New Biologist]{.underline} 1: 239-247, 1989.

7\. Muegge, K., Williams, T. M., Kant, J., Karin, M., Chiu, R., Schmidt,
A., Siebenlist, U., and Durum, S. K.: Interleukin-1 costimulatory
activity on the interleukin-2 promoter via AP-1. [Science]{.underline}
246: 249-251, 1989.

8\. Durum, S. K., Muegge, K., Aiello, F. B., and Takacs, L.: The
relationship between T cells and interleukin-1. In Faist,E. (Ed.):
Proceedings of the 1st Intl. Congress on the Immune Consequences of
Trauma, Shock and Sepsis. [Mechanisms and Therapeutic
Approaches]{.underline}. Springer Press, 1989, pp. 69-77.

9\. Smith, M. R., Muegge, K., Keller, J. R., Kung, H. -F., Young, H. A.,
and Durum, S. K.: Direct evidence for an intracellular role for
interferon-gamma: Microinjection of human interferon-gamma induces Ia
expression on murine macrophages. [J. Immunol]{.underline}. 144:
2505-2510, 1990.

10\. Muegge, K., Williams, T. M., Kant, J., Karin, M., Chiu, R.,
Schmidt, A., Siebenlist, U. and Durum, S. K.: Interleukin-1 activates
interleukin-2 via AP-1. In Oppenheim, J.J., Dinarello, C.A., Kluger, M.,
and Powanda, M. (Eds.): [The Molecular and Cellular Biology of
Cytokines]{.underline}. New York, John Wiley and Sons, 1990, pp.
185-189.

11\. Fagarasan, M., Aiello, F.B., Muegge, K., Durum, S. K., and Axelrod,
J.: Interleukin-1 induces beta-endorphin secretion via Fos and Jun in
AtT-20 pituitary cells. [Proc. Natl. Acad. Sci. USA]{.underline} 87:
7871-7881, 1990.

12\. Muegge, K. and Durum, S. K.: Cytokines and transcription factors.
[Cytokine]{.underline} 2: 1-8, 1990.

13\. Muegge, K. and Durum, S. K.: Assays for soluble and membrane-bound
interleukin-1. In Coligan, J.E., Kruisbeek, A.M., Margulies, D.H.,
Shevach, E.M., Strober, W. (Eds.): [Current Protocols in
Immunology]{.underline}. New York, John Wiley and Sons, 1: 6.2.1, 1991.

14\. Durum, S. K., Quinn, D. G., and Muegge, K.: New cytokines and their
receptors make their debut in San Antonio. [Immunol. Today]{.underline}
12: 54-57, 1991.

15\. Muegge, K. and Oppenheim, J. J.: IL-1 in autoimmunity. In Talal, N.
(Ed.): [Molecular Autoimmunity]{.underline}. London, Academic Press,
1991, pp. 153-176.

16\. Muegge, K., Vila, M., Musso, T., Herrlich, P., Stein, B., and
Durum, S. K.: IL-1 induction of JUN/AP-1. In Montovani, A. and Ghezzi,
P. (Eds.): [Pathophysiology and Pharmacology of Cytokines]{.underline}.
Biomedical Press, 1992, pp. 55-60.

17\. Muegge, K., Vila, M., Gusella, G. L., Musso, T., Herrlich, P.,
Stein, B., and Durum, S. K.: Interleukin-1 induction of the c-jun
promoter. [Proc. Natl. Acad. Sci. USA]{.underline}. 90: 7054-7058, 1993.

18\. Muegge, K., West, M., and Durum, S. K.: Recombination
sequence-binding protein in thymocytes undergoing T-cell receptor gene
rearrangement. [Proc. Natl. Acad. Sci. USA]{.underline}. 90: 4151-4155,
1993.

19\. Muegge, K., Vila, M. P., and Durum, S. K.: Interleukin-7: A
cofactor for V(D)J rearrangement of the T cell receptor beta gene.
[Science]{.underline} 261: 93-95, 1993.

20\. Durum, S. K. and Muegge, K. Cytokines linking the immune and
inflammatory systems: IL1, TNF, IL6, IFNαβ and TGFβ. In Rich, R. (Ed.):
[Clinical Immunology]{.underline}. St. Louis, Mosby, 1995, pp. 350-362.

21\. Jarvis, C. D., Geiman, T., Vila-Storm, M. P., Osipovich, O.,
Akella, U., Candéias, S., Nathan, I., Durum, S. K., and Muegge, K: A
novel putative helicase produced in early murine thymocytes.
[Gene]{.underline}. 169: 203-207, 1996.

22\. Muegge, K.: Meeting report of the 3rd International Cytokine
Society Conference. [Amyloid Int. J. Exp. Clin. Invest.]{.underline} 3:
140-143, 1996.

23\. Candias, S., Muegge, K., and Durum, S. K.: Junctional diversity in
signal joints from T cell receptor β and δ loci via terminal
deoxynuclotidy1 transferase and exonucleolytic activity. [J. Exp.
Med.]{.underline} 184: 1919-1926, 1996.

24\. Candeias, S., Muegge, K., and Durum, S.: IL-7 receptor and VDJ
recombination. Trophic versus mechanistic actions.
[Immunity]{.underline}. 6: 501-508, 1997.

25\. Kitazawa, H., Muegge, K., Badolato, R., Wang, J. M., Fogler, W. E.,
Ferris, D. K., Lee, C. K., Candeias, S., Smith, M. R., Oppenheim, J. J.,
and Durum, S. K.: IL-7 activates α~4~β~1~ integrin in murine thymocytes.
[J. Immunol.]{.underline} 159: 2259-2264, 1997.

26\. Durum, S. K. and Muegge, K. (Eds.): In [Cytokine
Knockouts]{.underline}, Totowa, New Jersey, Humana Press, 1997, pp.
1-482.

27\. Candeias, S., Peschon, J. J., Muegge, K., and Durum, S. K.:
Defective T-cell receptor γ gene rearrangement in interleukin-7 receptor
knockout mice. [Immunol. Lett.]{.underline} 57: 9-14, 1997.

28\. Lee, C. K., Kim, K., Muegge, K., and Durum, S. K.: Thymocytes
expressing both αβ and γδ TCRs: Implications for models of lineage
commitment. [Clin. Immunol.]{.underline} 17: 102-107, 1997.

29\. Osipovich, O., Durum, S. K., and Muegge, K.: Defining the minimal
domain of Ku80 for interaction with Ku70. [J. Biol. Chem.]{.underline}
272: 27259-27265, 1997.

30\. Candeias, S. M., Durum, S. K., and Muegge, K: p53-dependent
apoptosis and transcription of p21^waf/cip1/sdi1^ in SCID mice following
γ-irradiation. [Biochimie]{.underline} 79: 607-612, 1997.

31\. Kim, K., Lee, C. K., Sayers, T. J., Muegge, K., and Durum, S. K.:
The trophic action of IL-7 on pro-T cells: Inhibition of apoptosis of
pro-T1, -T2, and -T3 cells correlates with Bcl-2 and Bax levels and is
independent of Fas and p53 pathways. [J. Immunol.]{.underline} 160:
5735-5741, 1998.

32\. Durum, S. K., Lee, C. K., Geiman, T. M., Murphy, W. J., and Muegge,
K.: CD16 cross-linking blocks rearrangement of the TCRβ locus and
development of αβ T cells and induces development of NK cells from
thymic progenitos. [J. Immunol.]{.underline} 161: 3325-3329, 1998.

33\. Durum, S. K., Candeias, S., Nakajima, H., Leonard, W. J., Baird, A.
M., Berg, L. J., and Muegge, K.: IL-7 receptor control of T cell
receptor γ gene rearrangement: Role of receptor-associated chains and
locus accessibility. [J. Exp. Med.]{.underline} 188: 2233-2241, 1998.

34\. Geiman, T. M., Durum, S. K., and Muegge, K.: Characterization of
gene expression, genomic structure, and chromosomal localization of
*Hells* (Lsh). [Genomics]{.underline} 54: 477-483, 1998.

35\. Lee, C. K., Muegge, K., and Durum, S. K.: Cytokines in the
development of lymphocytes. In Theze (ed.): [The Cytokine Network and
Immune Functions.]{.underline} London, England, [Oxford University
Press,]{.underline} 1998.

36\. Lee, C. K., Kim, K., Geiman, T. M., Murphy, W. J., Muegge, K., and
Durum, S. K.: Cloning thymic precursor cells: Demonstration that
individual pro-T1 cells have dual T-NK potential and individual pro-T2
cells have dual αβ-γδ T cell potential. [Cell. Immunol.]{.underline}
191: 139-144, 1999.

37\. Osipovich, O., Duhe, R. J., Hasty, P., Durum, S. K., and Muegge,
K.: Defining functional domains of Ku80: DNA end binding and survival
after radiation. [Biochem. Biophys. Res. Commun.]{.underline} 261:
802-807, 1999.

38\. Hofmeister, R., Khaled, A.R., Benbernou, N., Rajnavolgyi, E.,
Muegge, K., and Durum, S. K.: Interleukin-7: physiological roles and
mechanisms of action. [Cytokine Growth Factor Rev.]{.underline}
10:41-60, 1999.

39\. Nathan, I., Dizdoroglu, M., Bernstein, L., Junker, U., Lee, C. K.,
Muegge, K., and Durum, S. K.: Induction of oxidative DNA damage in U937
cells by TNF and anti-Fas stimulation. [Cytokine]{.underline} 12:
881-887, 2000.

40\. Khaled, A. R., Kim, K., Hofmeister, R., Muegge, K., and Durum, S.
K.: Withdrawal of IL-7 induces Bax translocation from cytosol to
mitochondria through a rise in intracellular pH. [Proc. Natl. Acad. Sci.
USA]{.underline} 96: 14476-81, 1999.

41\. Benbernou, N., Muegge, K., and Durum, S. K.: Interleukin(IL)-7
induces rapid activation of Pyk2 which is bound to Jak 1 and IL-7Ralpha.
[J. Biol. Chem.]{.underline} 275: 7060-7065, 2000.

42\. Schlissel, M., Durum, S. D., and Muegge, K.: The IL-7 receptor is
required for TCRgamma locus accessibility to the V(D)J recombinase. [J.
Exp. Med.]{.underline} 191: 1045-1050, 2000.

43\. Geiman, T. M.and Muegge, K.: Lsh, an SNF2/helicase family member,
is required for proliferation of mature T lymphocytes. [Proc Natl Acad
Sci USA]{.underline} 97: 4772-4777, 2000.

44\. Khaled, A. R., Reynolds, D. A., YoungHA, Thompson, C. B., Muegge,
K., and Durum, S. K.: Interleukin-3 withdrawal induces an early increase
in mitochondrial membrane potential unrelated to the Bcl-2 family. Roles
ifn intracellular pH, ADP transport, and F(0)F(1)-ATPase. [J. Biol.
Chem.]{.underline} 276: 6453-6462, 2001.

45\. Lee, C. K., Kim, K., Welniak, L. A., Murphy, W. J., Muegge, K., and
Durum, S. K.: Thymic emigrants isolated by a new method possess unique
phenotypic and functional properties. [Blood]{.underline} 97: 1360-1369,
2001.

46\. Geiman, T. M., Tessarollo, L., Anver, M. R., Kopp, J. B., Ward, J.
M., and Muegge, K.: Lsh, a SNF2 family member, is required for normal
murine development. [Biochim. Biophys. Acta]{.underline} 1526: 211-220,
2001.

47\. Huang, J.and Muegge, K.: Control of chromatin accessibility for
V(D)J recombination by interleukin-7. [J. Leukoc. Biol.]{.underline} 69:
907-911, 2001.

48\. Khaled, A., Moor, A. N, Li, A. Kim, K., Ferris, D., Muegge, K.,
Fisher, R. J., Fliegel, L., and Durum, S. K.: Trophic factor withdrawal:
p38 mitogen-activated protein kinase activates NHE1, which induces
intracellular alkalinization. [Mol. Cell. Biol.]{.underline} 21:
7545-7557, 2001.

49\. Huang, J. Q., Durum, S. K., and Muegge, K.: Cutting edge: Histone
acetylation and recombination at the TCR gamma locus follows IL-7
induction. [J. Immunol.]{.underline} 167: 6073-6077, 2001.

50\. Dennis, K., Fan, T., Geiman, T. M., Yan, Q. S., and Muegge, K.:
Lsh, a member of the SNF2 family, is required for genome wide
methylation. [Genes.& Dev.]{.underline} 15: 2940-2944, 2001.

51\. Khaled, A.R., Kim, K., Muegge, K., Thompson, C., Fliegel, L., and
Durum, S.K.: Trophic factor withdrawal induces a novel pathway: p38 Mapk
activates NHE1 resulting in intracellular alkalinization, an early step
in apoptosis[.]{.smallcaps} [Scientific World]{.underline}
[Journal]{.underline} 1(1 Suppl 3):93, 2001.

52\. Muegge, K.: Preparing the target for the bullet. [Nature
Immunol.]{.underline} 3: 16-17, 2002.

53\. Khaled, A. R, Li, W. Q., Huang, J., Fry, T. J, Khaled, A. S.,
Mackall, C. L., Muegge, K., Young, H. A. and Durum, S. K. : Bax
deficiency partially corrects interleukin-7 receptor alpha deficiency.
[Immunity]{.underline} 17 :561-573, 2002.

54\. Rajnavolgyi, E., Benbernou, N., Rethi, B., Reynolds, D., Young,
H.A., Magocsi, M., Muegge, K., and Durum, S.K. : IL-7 withdrawal induces
a MAP kinase stress response. [Cell Signal]{.underline} 14: 761-769,
2002.

55\. Muegge, K. Modifications of histone cores and tails in V(D)J
recombination. [Genome Biol]{.underline}. 4: 211, 2003.

56\. Fan, T. Yan, Q., Huang, J., Austin, S. Cho, E., Ferris, D., and
Muegge, K. Number range CHAPTERLsh deficient murine embryonal
fibroblasts show reduced proliferation with signs of abnormal mitosis.
[Cancer Research]{.underline} 63:4677- 4683, 2003.

57\. Yan, Q., Cho, E., Lockett, S., and Muegge, K. Association of Lsh, a
regulator of DNA methylation, with pericentromeric heterochromatin is
dependent on intact heterochromatin. [Mol. Cell. Biol.]{.underline}
23:8416-8428, 2003.

58\. Yan, Q., Huang, J., Fan, T., Zhu, H. and Muegge, K. Lsh, a
modulator of CpG methylation, is crucial for normal histone methylation.
[Embo. J.]{.underline} 22: 5154-5162, 2003.

59\. Muegge, K. Young, H., Ruscetti, F. and Mikovits, J. Epigenetic
control during lymphoid development and immune responses: Aberrant
regulation, Viruses and Cancer. [Ann N Y Acad Sci]{.underline}. 983:
55-70, 2003.

60\. Khaled, A.R., Li, W.Q., Huang, J., Fry, T.J., Khaled, A.S.,
Mackall, C.L., Muegge, K., and Durum, S.K. Resurrection in the thymus.
[CCR Frontiers in Science]{.underline}. 2:4-5, 2003.

61\. Huang, J., Fan, T., Yan, Q., Zhu, H., Fox, S., Issaq, H.J., Best,
L., Gangi, L., Munroe, D. and Muegge, K. Lsh, an epigenetic guardian of
repetitive elements. [Nucleic Acids Res.]{.underline} 32: 5019-5018,
2004.

62\. Muegge, K. DNA methylation connects to histone lysine methylation.
[CCR Frontiers in Science.]{.underline} 3:3-4, 2004.

63\. Fan, T., Hagan, J.P., Kozlov, S.V., Stewart, C.L., and Muegge, K.
Lsh controls silencing of the imprinted *Cdkn1c* gene.
[Development]{.underline}. 132: 635-644, 2005.

64\. Muegge, K. Lsh, a guardian of heterochromatin at repeat elements.
Review. [Biochemistry and Cell Biology.]{.underline} 2005. 83: 548-554,
2005.

65\. Muegge, K. Lsh, a guardian of heterochromatin. [CCR Frontiers in
Science]{.underline}. 4:3-4, 2005.

66\. Heming, Z., Geiman, T.M., Xi, S., Schmidtmann, A., Jiang, Q., Chen,
T., Li, E., and Muegge, K. Lsh is involved in de novo methylation of
DNA. [Embo J.]{.underline} 25: 335-345, 2006.

67\. De La Fuente, R., Baumann, C., Fan, T., Schmidtmann, A., Dobrinski,
I., and Muegge, K. Lsh is required for meiotic chromosome synapsis and
recombination in female germ cells. [Nat Cell Biol]{.underline} (in
press).