**Recommended Format: Table of Contents**

**NOTE: Source of forms is given in red for convenience in
preparation.**

**Please remove source (red print) in the final document.**

  

**Table of Contents**

 

**SECTION 1.  GENERAL INFORMATION for the Entire Application Page**

1\. Face Page (PHS 398) 1

2\. Description, Performance Sites, Key Personnel, and Other Significant
Contributors (PHS 398) 2-X

3\. Table of Contents (Recommended Format)

4\. Budgets and Budget Justifications for the entire application

> Detailed Budget for First 12-Month Grant Period (PHS 398)
>
> Budget for Entire Proposed Project Period (PHS 398)

Table IA (Recommended Format): Consolidated Direct Costs for the First
12-month Grant Period

Table IB (Recommended Format): Consolidated Direct Costs for Entire
Proposed Project Period

Budgets for Consortium/Contractual Arrangements for the First 12-month
Grant Period (PHS 398)

Budgets for Consortium/Contractual Arrangements for the Entire Proposed
Project Period (PHS 398)

5\. Biographical Sketches of Principal Investigator, Key Personnel, and
Other Significant Contributors (in alphabetical order) (PHS 398)

6\. Table II (Recommended Format): Distribution of Professional Effort
(Person Months) on this Application

7\. Resources and Environment (Resources available to all Center
Projects and Cores) (PHS 398)

 

# SECTION 2.  SUMMARY RESEARCH PLAN for the Entire Application

1.  Introduction to the Application (Specific Aims, Background and
Significance)\* (PHS 398)

2.  Preliminary Studies/Progress Report (PHS 398)

3.  Human Subjects (PHS 398)

4.  Vertebrate Animals (PHS 398)

5.  Literature Cited (PHS 398)

6.  Consortium/Contractual Arrangements (PHS 398)

7.  Consultants (PHS 398)

8\. Table III (Recommended Format): Percentage Distribution of Research
Resource Cores to OAIC and Externally-funded Research Projects

Personnel Report (competing renewal applications only) (PHS 398)

  

**SECTION 3. LEADERSHIP/ADMINISTRATIVE CORE (LAC)**

1\. Title Page (Recommended Format)

2\. Budget for First 12-Month Period and for Entire Project Period for
LAC (PHS 398)

Budgets for Consortium/Contractual Arrangements for LAC (PHS 398)

3\. Biographical Sketches of Core Leader, Key Personnel, and Other
Significant Contributors (PHS 398)

4\. Resources and Environment (PHS 398)

5\. Overview of LAC\*

> a\. Administrative Structure and Activities
>
> b\. Progress Report (continuing renewal applications only)

6\. Advisory Panels and Committees

> a\. External Advisory Committee
>
> b\. Other Advisory Panels

**SECTION 4. RESEARCH CAREER DEVELOPMENT CORE (RCDC**)

1\. Title Page (Recommended Format)

2\. Budget for First 12-Month Period and for Entire Project Period for
RCDC (PHS 398)

Budgets for Consortium/Contractual Arrangements for RCDC (PHS 398)

3\. Biographical Sketches of Core Leader, Key Personnel, and Other
Significant Contributors (PHS 398)

4\. Resources and Environment (PHS 398)

5\. Overview\*

> a\. Administrative Structure and Activities
>
> b\. Procedures for Recruitment, Selection, Mentoring and Monitoring
> Progress
>
> c\. Gender/Minority Enrollment Table (Target Population)
>
> d\. Other RCDC Activities
>
> e\. Progress Report (continuing renewal applications only)

6\. Career Development Candidates

a\. Candidate 1

Biographical Sketch

Career Development Plan

b\. Candidate 2

Biographical Sketch

Career Development Plan

Etc. for remaining Candidates

7\. Human Subjects for RCDC

8\. Vertebrate Animals for RCDC

9\. Literature Cited

10\. Consultants

11\. Consortium/Contractural Arrangements

**SECTION 5. RESOURCE CORE 1 (Repeat for each Resource Core: Section 6.
Research Core 2, etc.)**

1\. Title Page (Recommended Format)

2\. Budget for First 12-Month Period and for Entire Project Period (PHS
398)

Budgets for Consortium/Contractual Arrangements (PHS 398)

3\. Biographical Sketches of Core Leader, Key Personnel, and Other
Significant Contributors (PHS 398)

4\. Resources and Environment

5\. Overview\*

a\. Specific Aims of the Core

b\. Administration

c\. Proposed Core Services and/or Activities

d\. Progress Report (continuing renewal applications only)

6\. External Projects

7\. Developmental Projects -- Administration

8\. Individual Developmental Projects

9\. Human Subjects

10\. Vertebrate Animals

11\. Literature Cited

12\. Consultants

13\. Consortium/Contractural Arrangements

**SECTION (5+ number of RCs). PILOT/EXPLORATORY STUDIES CORE (PESC)**

1\. Title Page (Recommended Format)

2\. Budget for First 12-Month Period and for Entire Project Period (PHS
398)

Budgets for Consortium/Contractual Arrangements (PHS 398)

3\. Biographical Sketches of Core Leader, Key Personnel, and Other
Significant Contributors (PHS 398)

4\. Resources and Environment

5\. Overview of Proposed Core Activities\*

a\. Specific Aims of the Core

b\. Background and Significance

c\. Administration

d\. Proposed Core Services and/or Activities

e\. List of Proposed Pilot/Exploratory Studies (PES)

f\. Progress Report (continuing renewal applications only)

6\. Human Subjects

7\. Vertebrate Animals

8\. Literature Cited

9\. Consultants

10\. Consortium/Contractural Arrangements

**SECTION (6+number of RCs). PILOT/EXPLORATORY STUDIES (PES)**

**PES-1 (Repeat for each PES )**

1\. Title Page (Recommended Format)

2\. Budget for First 12-Month Period and for Entire Project Period (PHS
398)

Budgets for Consortium/Contractual Arrangements (PHS 398)

3\. Biographical Sketches of Project Leader and Key Personnel (PHS 398)

4\. Resources and Environment

5\. Research Plan

a\. Specific Aims

b\. Background and Significance

c\. Preliminary Studies

d\. Experimental Design and Methods

6\. Human Subjects

7\. Vertebrate Animals

8\. Literature Cited

9\. Consultants

10\. Consortium/Contractural Arrangements

**SECTION (7+ number of RCs). OAIC COORDINATING CENTER CORE (CCC)**

**Include this section as an OAIC Core only if the applicant Institution
is applying for the Coordinating Center (CC) award in addition to an
OAIC site award.**

1\. Title page (Recommended Format)  

2\. Budgets for First 12-month Budget Period and for Entire Period for
Individual Core (PHS 398)

Budgets for Consortium/Contractual Arrangements (PHS 398)

3\. Biographical Sketches Core Leader, Key Personnel, and Other
Significant Contributors (PHS 398)

4\. Resources and Environment

5\. Core Structure

a.  Specific Aims of Core

b.  Administration

6\. Core Functions

a.  Background and Significance.

b.  Proposed Core Services and/or Activities.

c.  Progress Report (continuing renewal applications only)

7\. Literature Cited

8\. Consultants

9\. Consortium/Contractural Arrangements

\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_ 

\* Include Response to Previous Review for revised applications.

**NIH Checklist (PHS 398)**

**APPENDIX MATERIALS (Electronic files on disc)**

Note: Table of Contents for Appendix materials should be included at the
end of the main Table of Contents for the application and in a separate
file on the CD.

1\. Overall OAIC Program

2\. LAC

3\. RCDC

4\. Resource Core 1

5\. Resource Core 2 etc.

6\. PESC

a\. PES1

b\. PES2 etc.

###### RECOMMENDED FORMAT: TITLE PAGE FOR INDIVIDUAL CORE

(This is NOT the Face Page from PHS Form 398)

 

 

Core:  \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_

 

Title of Core (not to exceed 56 spaces):

 

Core Leader:  (Last Name, First Name, Middle Initial)

 

Position Title:

 

Department, service, laboratory, or equivalent:

 

Mailing Address:

 

Human Subjects (yes or no): If yes, state pages where a description of
the plan for protection of human subjects can be found and the pages
where a description detailing the participation by minority and female
subjects can be found.

 

Vertebrate Animals Involved (yes or no): If \"yes,\" identify by common
names and underline primates. State pages where a description of the
plan for the protection of animals can be found.  Also, if available,
state the page number where the IACUC approval can be found.  Otherwise,
Just-In-Time procedures are applicable. 

 

Dates of Entire Proposed Project Period (if different from that of the
entire application):

 

**RECOMMENDED FORMAT:**

**CONSOLIDATED DIRECT COSTS**

 

 

+-----------------+-----+-----+-----+-----+-----+-----+-----+---------+
| TABLE IA        |     |     |     |     |     |     |     |         |
|                 |     |     |     |     |     |     |     |         |
| CONSOLIDATED    |     |     |     |     |     |     |     |         |
| DIRECT COSTS    |     |     |     |     |     |     |     |         |
| FOR FIRST       |     |     |     |     |     |     |     |         |
| 12-MONTH GRANT  |     |     |     |     |     |     |     |         |
| PERIOD          |     |     |     |     |     |     |     |         |
+-----------------+-----+-----+-----+-----+-----+-----+-----+---------+
| BUDGET CATEGORY | LAC | R   | RC  | RC  | RC  | P   | CCC | TOTALS  |
|                 |     | CDC | 1   | 2   | 3   | ESC |     |         |
|                 | PI: |     | CL: | CL: |     |     | CL: |         |
|                 |     | CL: |     |     | CL: | CL: |     |         |
+-----------------+-----+-----+-----+-----+-----+-----+-----+---------+
| Personnel       |     |     |     |     |     |     |     |         |
+-----------------+-----+-----+-----+-----+-----+-----+-----+---------+
| Consulting      |     |     |     |     |     |     |     |         |
| Costs           |     |     |     |     |     |     |     |         |
+-----------------+-----+-----+-----+-----+-----+-----+-----+---------+
| Equipment       |     |     |     |     |     |     |     |         |
+-----------------+-----+-----+-----+-----+-----+-----+-----+---------+
| Supplies        |     |     |     |     |     |     |     |         |
+-----------------+-----+-----+-----+-----+-----+-----+-----+---------+
| Domestic Travel |     |     |     |     |     |     |     |         |
+-----------------+-----+-----+-----+-----+-----+-----+-----+---------+
| Foreign Travel  |     |     |     |     |     |     |     |         |
+-----------------+-----+-----+-----+-----+-----+-----+-----+---------+
| Patient Care    |     |     |     |     |     |     |     |         |
| Costs           |     |     |     |     |     |     |     |         |
+-----------------+-----+-----+-----+-----+-----+-----+-----+---------+
| Alterati        |     |     |     |     |     |     |     |         |
| ons/Renovations |     |     |     |     |     |     |     |         |
+-----------------+-----+-----+-----+-----+-----+-----+-----+---------+
| Contractual     |     |     |     |     |     |     |     |         |
| Costs           |     |     |     |     |     |     |     |         |
+-----------------+-----+-----+-----+-----+-----+-----+-----+---------+
| Other Expenses  |     |     |     |     |     |     |     |         |
+-----------------+-----+-----+-----+-----+-----+-----+-----+---------+
|                 |     |     |     |     |     |     |     |         |
+-----------------+-----+-----+-----+-----+-----+-----+-----+---------+
| TOTALS          |     |     |     |     |     |     |     |         |
+-----------------+-----+-----+-----+-----+-----+-----+-----+---------+
| PI: Principal   |     |     |     |     |     |     |     |         |
| Investigator;   |     |     |     |     |     |     |     |         |
| CL : Core       |     |     |     |     |     |     |     |         |
| Leader          |     |     |     |     |     |     |     |         |
+-----------------+-----+-----+-----+-----+-----+-----+-----+---------+

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+-----------------+-----+-----+-----+-----+-----+-----+-----+---------+
| TABLE IB        |     |     |     |     |     |     |     |         |
|                 |     |     |     |     |     |     |     |         |
| CONSOLIDATED    |     |     |     |     |     |     |     |         |
| DIRECT COSTS    |     |     |     |     |     |     |     |         |
| FOR ENTIRE      |     |     |     |     |     |     |     |         |
| PROPOSED        |     |     |     |     |     |     |     |         |
| PROJECT PERIOD  |     |     |     |     |     |     |     |         |
+-----------------+-----+-----+-----+-----+-----+-----+-----+---------+
| BUDGET CATEGORY | LAC | R   | RC  | RC  | RC  | P   | CCC | TOTALS  |
|                 |     | CDC | 1   | 2   | 3   | ESC |     |         |
|                 | PI: |     | CL: | CL: |     |     | CL: |         |
|                 |     | CL: |     |     | CL: | CL: |     |         |
+-----------------+-----+-----+-----+-----+-----+-----+-----+---------+
| Personnel       |     |     |     |     |     |     |     |         |
+-----------------+-----+-----+-----+-----+-----+-----+-----+---------+
| Consulting      |     |     |     |     |     |     |     |         |
| Costs           |     |     |     |     |     |     |     |         |
+-----------------+-----+-----+-----+-----+-----+-----+-----+---------+
| Equipment       |     |     |     |     |     |     |     |         |
+-----------------+-----+-----+-----+-----+-----+-----+-----+---------+
| Supplies        |     |     |     |     |     |     |     |         |
+-----------------+-----+-----+-----+-----+-----+-----+-----+---------+
| Domestic Travel |     |     |     |     |     |     |     |         |
+-----------------+-----+-----+-----+-----+-----+-----+-----+---------+
| Foreign Travel  |     |     |     |     |     |     |     |         |
+-----------------+-----+-----+-----+-----+-----+-----+-----+---------+
| Patient Care    |     |     |     |     |     |     |     |         |
| Costs           |     |     |     |     |     |     |     |         |
+-----------------+-----+-----+-----+-----+-----+-----+-----+---------+
| Alterati        |     |     |     |     |     |     |     |         |
| ons/Renovations |     |     |     |     |     |     |     |         |
+-----------------+-----+-----+-----+-----+-----+-----+-----+---------+
| Contractual     |     |     |     |     |     |     |     |         |
| Costs           |     |     |     |     |     |     |     |         |
+-----------------+-----+-----+-----+-----+-----+-----+-----+---------+
| Other Expenses  |     |     |     |     |     |     |     |         |
+-----------------+-----+-----+-----+-----+-----+-----+-----+---------+
|                 |     |     |     |     |     |     |     |         |
+-----------------+-----+-----+-----+-----+-----+-----+-----+---------+
| TOTALS          |     |     |     |     |     |     |     |         |
+-----------------+-----+-----+-----+-----+-----+-----+-----+---------+
| PI: Principal   |     |     |     |     |     |     |     |         |
| Investigator;   |     |     |     |     |     |     |     |         |
| CL : Core       |     |     |     |     |     |     |     |         |
| Leader          |     |     |     |     |     |     |     |         |
+-----------------+-----+-----+-----+-----+-----+-----+-----+---------+

**RECOMMENDED FORMAT: DISTRIBUTION OF PROFESSIONAL EFFORT**

**(Person Months) ON THIS APPLICATION**

 

 

<table>
<colgroup>
<col style="width: 27%" />
<col style="width: 7%" />
<col style="width: 7%" />
<col style="width: 8%" />
<col style="width: 7%" />
<col style="width: 7%" />
<col style="width: 7%" />
<col style="width: 7%" />
<col style="width: 7%" />
<col style="width: 11%" />
</colgroup>
<tbody>
<tr class="odd">
<td colspan="10"><p>TABLE II</p>
<p>DISTRIBUTION OF PROFESSIONAL EFFORT (%) ON THIS APPLICATION</p></td>
</tr>
<tr class="even">
<td><p> Participating Investigators</p>
<p> </p></td>
<td><p>LAC</p>
<p>PI:</p></td>
<td><p>RCDC</p>
<p>CL:</p></td>
<td>RC  1 CL:</td>
<td>RC 2 CL:</td>
<td><p>RC 3</p>
<p>CL:</p></td>
<td>. . .</td>
<td>. . .</td>
<td><p>CCC</p>
<p>CL:</p></td>
<td>TOTALS</td>
</tr>
<tr class="odd">
<td>Dr. A (PI)</td>
<td> </td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr class="even">
<td>Dr. B</td>
<td> </td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr class="odd">
<td>Dr. C</td>
<td> </td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr class="even">
<td>Dr. D</td>
<td> </td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr class="odd">
<td>Dr. E</td>
<td> </td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr class="even">
<td>Dr. F</td>
<td> </td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr class="odd">
<td> </td>
<td> </td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr class="even">
<td> </td>
<td> </td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr class="odd">
<td> </td>
<td> </td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr class="even">
<td> </td>
<td> </td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr class="odd">
<td> </td>
<td> </td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr class="even">
<td>TOTALS</td>
<td> </td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr class="odd">
<td colspan="10">PI: Principal Investigator; CL: Core Leader</td>
</tr>
</tbody>
</table>

####### 

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**RECOMMENDED FORMAT: PERCENTAGE DISTRIBUTION OF RESEARCH CORES TO OAIC
AND EXTERNALLY FUNDED RESEARCH PROJECTS**

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+-----------------+---------------------+------+------+------+-------+
| TABLE III       |                     |      |      |      |       |
|                 |                     |      |      |      |       |
|                 |                     |      |      |      |       |
|                 |                     |      |      |      |       |
| PERCENTAGE      |                     |      |      |      |       |
| DISTRIBUTION OF |                     |      |      |      |       |
| RESEARCH CORES  |                     |      |      |      |       |
| TO OAIC &       |                     |      |      |      |       |
| EXTERNALLY      |                     |      |      |      |       |
| FUNDED RESEARCH |                     |      |      |      |       |
| PROJECTS        |                     |      |      |      |       |
+-----------------+---------------------+------+------+------+-------+
|                 | PI;                 |      |      |      |       |
|                 |                     |      |      |      |       |
| RESEARCH        | PROJECT TERM;       | RC   | RC   | RC   | RC 4: |
| PROJECTS        |                     | 1:   | 2:   | 3:   |       |
|                 | CURRENT YEAR DIRECT |      |      |      | TITLE |
|                 | COST                | T    | T    | T    |       |
|                 |                     | ITLE | ITLE | ITLE |       |
+-----------------+---------------------+------+------+------+-------+
|                 |                     |      |      |      |       |
|                 |                     |      |      |      |       |
| EXTERNAL        |                     |      |      |      |       |
| PROJECT 1       |                     |      |      |      |       |
+-----------------+---------------------+------+------+------+-------+
|                 |                     |      |      |      |       |
|                 |                     |      |      |      |       |
| EXTERNAL        |                     |      |      |      |       |
| PROJECT 2       |                     |      |      |      |       |
+-----------------+---------------------+------+------+------+-------+
|                 |                     |      |      |      |       |
|                 |                     |      |      |      |       |
| EXTERNAL        |                     |      |      |      |       |
| PROJECT 3       |                     |      |      |      |       |
+-----------------+---------------------+------+------+------+-------+
|                 |                     |      |      |      |       |
|                 |                     |      |      |      |       |
| EXTERNAL        |                     |      |      |      |       |
| PROJECT 4       |                     |      |      |      |       |
+-----------------+---------------------+------+------+------+-------+
|                 |                     |      |      |      |       |
|                 |                     |      |      |      |       |
| Developmental   |                     |      |      |      |       |
| Project 1       |                     |      |      |      |       |
+-----------------+---------------------+------+------+------+-------+
|                 |                     |      |      |      |       |
|                 |                     |      |      |      |       |
| Developmental   |                     |      |      |      |       |
| Project 2       |                     |      |      |      |       |
+-----------------+---------------------+------+------+------+-------+
|                 |                     |      |      |      |       |
|                 |                     |      |      |      |       |
| Developmental   |                     |      |      |      |       |
| Project 3       |                     |      |      |      |       |
+-----------------+---------------------+------+------+------+-------+
|                 |                     |      |      |      |       |
|                 |                     |      |      |      |       |
| Developmental   |                     |      |      |      |       |
| Project 4       |                     |      |      |      |       |
+-----------------+---------------------+------+------+------+-------+
| Pi              |                     |      |      |      |       |
| lot/Exploratory |                     |      |      |      |       |
| Study 1         |                     |      |      |      |       |
+-----------------+---------------------+------+------+------+-------+
| Pi              |                     |      |      |      |       |
| lot/Exploratory |                     |      |      |      |       |
| Study 2         |                     |      |      |      |       |
+-----------------+---------------------+------+------+------+-------+
| Pi              |                     |      |      |      |       |
| lot/Exploratory |                     |      |      |      |       |
| Study 3         |                     |      |      |      |       |
+-----------------+---------------------+------+------+------+-------+
| Pi              |                     |      |      |      |       |
| lot/Exploratory |                     |      |      |      |       |
| Study 4         |                     |      |      |      |       |
+-----------------+---------------------+------+------+------+-------+
| Pi              |                     |      |      |      |       |
| lot/Exploratory |                     |      |      |      |       |
| Study 5         |                     |      |      |      |       |
+-----------------+---------------------+------+------+------+-------+

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