> **Table 1. Summary of Quantitative Relationships of IQ and Blood Pb
> for Two Sets of Studies Discussed Above.**

+---------------+-------------+------------+---+----+----+-----+-----+
| **Stu         | **Study     | **         | * | *  | *  | **F | **A |
| dy/Analysis** | Cohort**    | Analysis** | * | *R | *G | orm | ver |
|               |             |            | N | an | eo | of  | age |
|               |             | *          | * | ge | me | Mo  | Lin |
|               |             | *Dataset** | * | B  | tr | del | ear |
|               |             |            |   | LL | ic | f   | S   |
|               |             |            |   | ** | Me | rom | lop |
|               |             |            |   |    | an | wh  | e^A |
|               |             |            |   | *  | B  | ich | ^** |
|               |             |            |   | *( | LL | A   |     |
|               |             |            |   | ** | (  | ver | **( |
|               |             |            |   | µg | ** | age | poi |
|               |             |            |   | /d | µg | Sl  | nts |
|               |             |            |   | L) | /d | ope | per |
|               |             |            |   |    | L) | Der | µg  |
|               |             |            |   | \[ |    | ive | /dL |
|               |             |            |   | 5^ |    | d** | )** |
|               |             |            |   | th |    |     |     |
|               |             |            |   | ^- |    |     |     |
|               |             |            |   | 95 |    |     |     |
|               |             |            |   | ^t |    |     |     |
|               |             |            |   | h^ |    |     |     |
|               |             |            |   | pe |    |     |     |
|               |             |            |   | rc |    |     |     |
|               |             |            |   | en |    |     |     |
|               |             |            |   | ti |    |     |     |
|               |             |            |   | le |    |     |     |
|               |             |            |   | \] |    |     |     |
+---------------+-------------+------------+---+----+----+-----+-----+
| **Set of      |             |            |   |    |    |     |     |
| studies with  |             |            |   |    |    |     |     |
| steeper       |             |            |   |    |    |     |     |
| slopes at     |             |            |   |    |    |     |     |
| lower mean    |             |            |   |    |    |     |     |
| blood Pb      |             |            |   |    |    |     |     |
| levels**      |             |            |   |    |    |     |     |
+---------------+-------------+------------+---+----+----+-----+-----+
| Tellez-Rojo   | Mexico      | Children - | 1 | 0  | 2  | Lin | -1  |
| \<5 subgroup  | City, age   | BLL\<5     | 9 | .8 | .9 | ear | .71 |
|               | 24 mo       | µg/dL      | 3 | -- |    |     |     |
|               |             |            |   | 4  |    |     |     |
|               |             |            |   | .9 |    |     |     |
+---------------+-------------+------------+---+----+----+-----+-----+
| *based on     | *Datast     |            |   |    |    | *L  | *-2 |
| Lanphear et   | from which  |            |   |    |    | LL^ | .29 |
| al 2005^B^,*  | the         |            |   |    |    | C^* | at* |
|               | log-linear  |            |   |    |    |     |     |
| *Log-linear   | function is |            |   |    |    |     | *2  |
| with          | derived is  |            |   |    |    |     | µg/ |
| low-exposure  | the pooled  |            |   |    |    |     | dL^ |
| linearization | In          |            |   |    |    |     | C^* |
| (LLL)^B^*     | ternational |            |   |    |    |     |     |
|               | dataset of  |            |   |    |    |     |     |
|               | 1333        |            |   |    |    |     |     |
|               | children,*  |            |   |    |    |     |     |
|               |             |            |   |    |    |     |     |
|               | *age 6-10   |            |   |    |    |     |     |
|               | yr, having  |            |   |    |    |     |     |
|               | median      |            |   |    |    |     |     |
|               | blood Pb of |            |   |    |    |     |     |
|               | 9.7 µg/dL   |            |   |    |    |     |     |
|               | and 5^th^   |            |   |    |    |     |     |
|               | -95^th^     |            |   |    |    |     |     |
|               | percentile  |            |   |    |    |     |     |
|               | of 2.5-33.2 |            |   |    |    |     |     |
|               | µg/dL.*     |            |   |    |    |     |     |
|               |             |            |   |    |    |     |     |
|               | *Slope      |            |   |    |    |     |     |
|               | presented   |            |   |    |    |     |     |
|               | here is the |            |   |    |    |     |     |
|               | slope at a  |            |   |    |    |     |     |
|               | blood Pb    |            |   |    |    |     |     |
|               | level of 2  |            |   |    |    |     |     |
|               | µg/dL. ^C^* |            |   |    |    |     |     |
+---------------+-------------+------------+---+----+----+-----+-----+
| Lanphear et   | Pooled      | Children - | 1 | \  | 3. | Lin | -2  |
| al 2005 \<7.5 | Int         | peak BLL   | 0 | [1 | 24 | ear | .94 |
| peak subgroup | ernational, | \<7.5      | 3 | .3 |    |     |     |
|               | age 6-10 yr | µg/dL      |   | -6 |    |     |     |
|               |             |            |   | .0 |    |     |     |
|               |             |            |   | \] |    |     |     |
+---------------+-------------+------------+---+----+----+-----+-----+
| **Set of      |             |            |   |    |    |     |     |
| studies with  |             |            |   |    |    |     |     |
| generally     |             |            |   |    |    |     |     |
| higher mean   |             |            |   |    |    |     |     |
| blood Pb      |             |            |   |    |    |     |     |
| lev           |             |            |   |    |    |     |     |
| els(presented |             |            |   |    |    |     |     |
| in Criteria   |             |            |   |    |    |     |     |
| Document,     |             |            |   |    |    |     |     |
| Table         |             |            |   |    |    |     |     |
| 6-1)^D^**     |             |            |   |    |    |     |     |
+---------------+-------------+------------+---+----+----+-----+-----+
| Canfield et   | Rochester,  | Children-  | 7 | U  | 3. | Lin | -1  |
| al 2003, \<10 | age 5 yr    | peak BLL   | 1 | ns | 32 | ear | .79 |
| peak subgroup |             | \<10 µg/dL |   | pe |    |     |     |
|               |             |            |   | ci |    |     |     |
|               |             |            |   | fi |    |     |     |
|               |             |            |   | ed |    |     |     |
+---------------+-------------+------------+---+----+----+-----+-----+
| Bellinger and | Boston      | Children - | 4 | 1  | 3. | Lin | -1  |
| Needleman     | ^A,E^       | peak BLL   | 8 |  - | 8^ | ear | .56 |
| 2003          |             | \<10 µg/dL |   | 9  | E^ |     |     |
|               |             |            |   | .3 |    |     |     |
|               |             |            |   | ^  |    |     |     |
|               |             |            |   | E^ |    |     |     |
+---------------+-------------+------------+---+----+----+-----+-----+
| Tellez-Rojo   | Mexico      | Full       | 2 | 0  | 4. | Lin | -1  |
| et al 2006    | City, age   | dataset    | 9 | .8 | 28 | ear | .04 |
|               | 24 mo       |            | 4 |  - |    |     |     |
|               |             |            |   | \< |    |     |     |
|               |             |            |   | 10 |    |     |     |
+---------------+-------------+------------+---+----+----+-----+-----+
| Tellez-Rojo   | Mexico      | Full       | 2 | 0  | 4. | L   | -0  |
| et al 2006    | City, age   | dataset    | 9 | .8 | 28 | og- | .94 |
| full --       | 24 mo       |            | 4 |  - |    | lin |     |
| loglinear     |             |            |   | \< |    | ear |     |
|               |             |            |   | 10 |    |     |     |
+---------------+-------------+------------+---+----+----+-----+-----+
| Lanphear et   | Pooled      | Children - | 2 | \  | 4. | Lin | -0  |
| al 2005, \<10 | Int         | peak BLL   | 4 | [1 | 30 | ear | .80 |
| peak^F^       | ernational, | \<10 µg/dL | 4 | .4 |    |     |     |
| subgroup      | age 6-10 yr |            |   | -8 |    |     |     |
|               |             |            |   | .0 |    |     |     |
|               |             |            |   | \] |    |     |     |
+---------------+-------------+------------+---+----+----+-----+-----+
| Al-Saleh et   | Saudia      | Full       | 5 | 2  | 7. | L   | -0  |
| al 2001 full  | Arabia, age | dataset    | 3 | .3 | 44 | og- | .76 |
| -- loglinear  | 6-12 yr     |            | 3 | -- |    | lin |     |
|               |             |            |   | 2  |    | ear |     |
|               |             |            |   | 7. |    |     |     |
|               |             |            |   | 36 |    |     |     |
|               |             |            |   | ^  |    |     |     |
|               |             |            |   | G^ |    |     |     |
+---------------+-------------+------------+---+----+----+-----+-----+
| Kordas et al  | Torreon,    | Children - | 3 | 2  | 7  | Lin | -0  |
| 2006, \<12    | Mexico, age | BLL\<12    | 7 | .3 | .9 | ear | .40 |
| subgroup      | 7 yr        | µg/dL      | 7 |  - |    |     |     |
|               |             |            |   | \< |    |     |     |
|               |             |            |   | 12 |    |     |     |
+---------------+-------------+------------+---+----+----+-----+-----+
| Lanphear et   | Pooled      | Full       | 1 | \[ | 9  | L   | -0  |
| al 2005 full  | Int         | dataset    | 3 | 2. | .7 | og- | .41 |
| -- loglinear  | ernational, |            | 3 | 5- | (m | lin |     |
|               | age 6-10 yr |            | 3 | 33 | ed | ear |     |
|               |             |            |   | .2 | ia |     |     |
|               |             |            |   | \] | n) |     |     |
+---------------+-------------+------------+---+----+----+-----+-----+
| **Median      |             |            |   |    |    |     | **  |
| value**       |             |            |   |    |    |     | -0. |
|               |             |            |   |    |    |     | 9^D |
|               |             |            |   |    |    |     | ^** |
+---------------+-------------+------------+---+----+----+-----+-----+
| ^A^ Average   |             |            |   |    |    |     |     |
| slope for     |             |            |   |    |    |     |     |
| change in IQ  |             |            |   |    |    |     |     |
| from 10^th^   |             |            |   |    |    |     |     |
| percentile to |             |            |   |    |    |     |     |
| 10 µg/dL      |             |            |   |    |    |     |     |
| Slope         |             |            |   |    |    |     |     |
| estimates     |             |            |   |    |    |     |     |
| here are for  |             |            |   |    |    |     |     |
| relationship  |             |            |   |    |    |     |     |
| between IQ    |             |            |   |    |    |     |     |
| and           |             |            |   |    |    |     |     |
| concurrent    |             |            |   |    |    |     |     |
| blood Pb      |             |            |   |    |    |     |     |
| levels (BLL), |             |            |   |    |    |     |     |
| except for    |             |            |   |    |    |     |     |
| Bellinger &   |             |            |   |    |    |     |     |
| Needleman     |             |            |   |    |    |     |     |
| which used 24 |             |            |   |    |    |     |     |
| month BLLs    |             |            |   |    |    |     |     |
| with 10 year  |             |            |   |    |    |     |     |
| old IQ.       |             |            |   |    |    |     |     |
|               |             |            |   |    |    |     |     |
| ^B^ The       |             |            |   |    |    |     |     |
| Lanphear et   |             |            |   |    |    |     |     |
| al 2005       |             |            |   |    |    |     |     |
| pooled        |             |            |   |    |    |     |     |
| International |             |            |   |    |    |     |     |
| study         |             |            |   |    |    |     |     |
| includes      |             |            |   |    |    |     |     |
| blood Pb data |             |            |   |    |    |     |     |
| from the      |             |            |   |    |    |     |     |
| Rochester and |             |            |   |    |    |     |     |
| Boston        |             |            |   |    |    |     |     |
| cohorts,      |             |            |   |    |    |     |     |
| although for  |             |            |   |    |    |     |     |
| different     |             |            |   |    |    |     |     |
| ages (6 and 5 |             |            |   |    |    |     |     |
| years,        |             |            |   |    |    |     |     |
| respectively) |             |            |   |    |    |     |     |
| than the ages |             |            |   |    |    |     |     |
| analyzed in   |             |            |   |    |    |     |     |
| Canfield et   |             |            |   |    |    |     |     |
| al 2003 and   |             |            |   |    |    |     |     |
| Bellinger and |             |            |   |    |    |     |     |
| Needleman     |             |            |   |    |    |     |     |
| 2003.         |             |            |   |    |    |     |     |
|               |             |            |   |    |    |     |     |
| ^C^The LLL    |             |            |   |    |    |     |     |
| function      |             |            |   |    |    |     |     |
| (described in |             |            |   |    |    |     |     |
| section       |             |            |   |    |    |     |     |
| II.C.2.b) was |             |            |   |    |    |     |     |
| developed     |             |            |   |    |    |     |     |
| from Lanphear |             |            |   |    |    |     |     |
| et al 2005    |             |            |   |    |    |     |     |
| loglinear     |             |            |   |    |    |     |     |
| model with a  |             |            |   |    |    |     |     |
| linearization |             |            |   |    |    |     |     |
| of the slope  |             |            |   |    |    |     |     |
| at BLL below  |             |            |   |    |    |     |     |
| 1 ug/dL. The  |             |            |   |    |    |     |     |
| slope shown   |             |            |   |    |    |     |     |
| is that at 2  |             |            |   |    |    |     |     |
| µg/dL. In     |             |            |   |    |    |     |     |
| estimating IQ |             |            |   |    |    |     |     |
| loss with     |             |            |   |    |    |     |     |
| this function |             |            |   |    |    |     |     |
| in the risk   |             |            |   |    |    |     |     |
| assessment    |             |            |   |    |    |     |     |
| (section      |             |            |   |    |    |     |     |
| II.C) and in  |             |            |   |    |    |     |     |
| the           |             |            |   |    |    |     |     |
| e             |             |            |   |    |    |     |     |
| vidence-based |             |            |   |    |    |     |     |
| c             |             |            |   |    |    |     |     |
| onsiderations |             |            |   |    |    |     |     |
| in section    |             |            |   |    |    |     |     |
| II.E.3, the   |             |            |   |    |    |     |     |
| nonlinear     |             |            |   |    |    |     |     |
| form of the   |             |            |   |    |    |     |     |
| model was     |             |            |   |    |    |     |     |
| used, with    |             |            |   |    |    |     |     |
| varying slope |             |            |   |    |    |     |     |
| for all BLL   |             |            |   |    |    |     |     |
| above 1       |             |            |   |    |    |     |     |
| µg/dL.        |             |            |   |    |    |     |     |
|               |             |            |   |    |    |     |     |
| ^D^ These     |             |            |   |    |    |     |     |
| studies and   |             |            |   |    |    |     |     |
| quantitative  |             |            |   |    |    |     |     |
| relationships |             |            |   |    |    |     |     |
| are discussed |             |            |   |    |    |     |     |
| in the        |             |            |   |    |    |     |     |
| Criteria      |             |            |   |    |    |     |     |
| Document (CD, |             |            |   |    |    |     |     |
| sections 6.2, |             |            |   |    |    |     |     |
| 6.2.1.3 and   |             |            |   |    |    |     |     |
| 8.6.2).       |             |            |   |    |    |     |     |
|               |             |            |   |    |    |     |     |
| ^E^ The BLL   |             |            |   |    |    |     |     |
| for Bellinger |             |            |   |    |    |     |     |
| and Needleman |             |            |   |    |    |     |     |
| (2003) are    |             |            |   |    |    |     |     |
| for age 24    |             |            |   |    |    |     |     |
| months.       |             |            |   |    |    |     |     |
|               |             |            |   |    |    |     |     |
| ^F^ As        |             |            |   |    |    |     |     |
| referenced    |             |            |   |    |    |     |     |
| above and in  |             |            |   |    |    |     |     |
| section       |             |            |   |    |    |     |     |
| II.C.2.b, the |             |            |   |    |    |     |     |
| form of this  |             |            |   |    |    |     |     |
| function      |             |            |   |    |    |     |     |
| derived for   |             |            |   |    |    |     |     |
| lifetime      |             |            |   |    |    |     |     |
| average blood |             |            |   |    |    |     |     |
| Pb was used   |             |            |   |    |    |     |     |
| in the        |             |            |   |    |    |     |     |
| economic      |             |            |   |    |    |     |     |
| analysis for  |             |            |   |    |    |     |     |
| the RRP rule. |             |            |   |    |    |     |     |
| The slope for |             |            |   |    |    |     |     |
| that function |             |            |   |    |    |     |     |
| was -0.88 IQ  |             |            |   |    |    |     |     |
| points per    |             |            |   |    |    |     |     |
| µg/dL         |             |            |   |    |    |     |     |
| lifetime      |             |            |   |    |    |     |     |
| averaged      |             |            |   |    |    |     |     |
| blood Pb.     |             |            |   |    |    |     |     |
|               |             |            |   |    |    |     |     |
| ^G^69% of     |             |            |   |    |    |     |     |
| children in   |             |            |   |    |    |     |     |
| Al-Saleh et   |             |            |   |    |    |     |     |
| al (2001)     |             |            |   |    |    |     |     |
| study had     |             |            |   |    |    |     |     |
| BLL\<10 µg/dL |             |            |   |    |    |     |     |
+---------------+-------------+------------+---+----+----+-----+-----+