**PRELIMINARY INFORMATION ON SEROLOGIC RESPONSES**

**TO INFLUENZA VIRUS VACCINES**

**PREPARED FOR**

**VACCINES AND RELATED BIOLOGICAL PRODUCTS ADVISORY COMMITTEE**

**18-19 FEBRUARY 2004**

# 

## 

**DATA FROM**

**CENTER FOR BIOLOGICS EVALUATION AND RESEARCH**

**BETHESDA, MARYLAND**

# CURRENT TO FEBRUARY 7, 2004 

**TABLE OF CONTENTS**

## 

## 

## 

## SerUM panelS .................................................................................3

## ANTIGENS ..........................................................................................4

## 

## H1N1 ADULT AND ELDERLY...............................................................5-6

## 

## H3N2 ADULT AND ELDERLY \...............................................................7-8

## 

## B ADULT AND ELDERLY ..................................................................9-10

## 

## 2001 VACCINE STUDY FOR B SEROLOGIES .........................................11

## 

## PEDIATRIC SEROLOGIES ...................................................................12

## 

## ACKNOWLEDGEMENTS......................................................................13

# 

# SERUM PANELS USED FOR STUDIES

**SERUM SUPPLIED BY VACCINE COMPONENTS**

**1. ALAN HAMPSON ADULTS A/NEW CALEDONIA/20/99-LIKE (H1N1)**

**WHO, MELBOURNE, AUSTRALIA ELDERLY A/PANAMA/2007/99 (H3N2)**

**B/SHANGDONG/07/97**

**2. JOHN WOOD, PH.D ADULTS A/NEW CALEDONIA/20/99 (H1N1)**

**NIBSC, LONDON, ENGLAND ELDERLY A/PANAMA/2007/99 (H3N2)**

**B/SHANGDONG/7/97**

**3. TAKATO ODIGARI, PH.D. ADULTS A/NEW CALEDONIA/20/99-LIKE (H1N1)**

**TOKYO, JAPAN ELDERLY A/PANAMA/2007/99-LIKE (H3N2)**

**B/HONG KONG/330/01-LIKE**

**4. STEFAN GRAVENSTEIN, M.D. ADULTS A/NEW CALEDONIA/20/99-LIKE (H1N1)**

**EASTERN VIRGINIA ELDERLY A/PANAMA/2007/99-LIKE (H3N2)**

**MEDICAL SCHOOL PEDIATRIC B/HONG KONG/330/01-LIKE**

**5. STEFAN GRAVENSTEIN, M.D. ADULTS A/NEW CALEDONIA/20/99-LIKE (H1N1)**

**EASTERN VIRGINIA ELDERLY A/PANAMA/2007/99-LIKE (H3N2)**

**MEDICAL SCHOOL B/VICTORIA/504/2000**

**(VACCINE USED IN 2001-02)**

# ANTIGENS FOR SEROLOGIES

**[H1N1]{.underline}**

####  A/New Caledonia/20/99 IVR116\* E9

**A/Belem/84066/03 (H1N2) E5**

**A/Virginia/20/03 X2C2E1**

**[H3N2]{.underline}**

**A/Panama/2007/99 RESVIR17\* E6**

**A/Texas/40/03 SpfCK4E4**

**A/Chile/8266e/2003** **SpfCK4E4**

**A/Fiujian/445/03 E6**

**A/Victoria/584/03 E4**

##  A/Texas/141/03 E4

##  A/Kumamoto/102/02 X4E6

###  A/Wyoming/03/03 SpfCK2E3

##  A/Hong Kong/1186/03 SpfCK3E4

**[B]{.underline}**

####  B/Shandong/07/97\* \*\* E8

**B/Hong Kong/1434/02\* \*\* E5**

**B/Sichuan/259/03\*\* C2E3**

**B/Jilin/20/03\*\* E5**

**\* = REPRESENTATIVE OF VACCINE STRAINS**

**\*\* = ETHER TREATED**

**E = EGG PASSED VIRUS**

**X = UNKNOWN**

**C = TISSUE CULTURE**

**SpfCK = SPECIFIC PATHOGEN FREE CHICK embryo KIDNEY**

**HEMAGGLUTINATION INHIBITION ANTIBODY TITERS TO INFLUENZA A (H1N1)
VIRUSES**

+-------+---+---+-------------------+-----+-----+-----+-----+----+
| **TR  | * | * | **VIRUS STRAIN**  | *   |     | **% |     | *  |
| IAL** | * | * |                   | *GM |     | [\> |     | *% |
|       | T | N |                   | T** |     | ]{. |     | 4  |
|       | E | O |                   |     |     | und |     | ** |
|       | S | . |                   | **  |     | erl |     |    |
|       | T | * |                   | PRE |     | ine |     | ** |
|       | * | * |                   | POS |     | }32 |     | FO |
|       | * |   |                   | T** |     | or4 |     | LD |
|       |   | * |                   |     |     | 0** |     | ** |
|       | * | * |                   |     |     |     |     |    |
|       | * | O |                   |     |     | **  |     | ** |
|       | S | F |                   |     |     | PRE |     | RI |
|       | I | * |                   |     |     | POS |     | SE |
|       | T | * |                   |     |     | T** |     | ** |
|       | E |   |                   |     |     |     |     |    |
|       | * | * |                   |     |     |     |     |    |
|       | * | * |                   |     |     |     |     |    |
|       |   | S |                   |     |     |     |     |    |
|       |   | E |                   |     |     |     |     |    |
|       |   | R |                   |     |     |     |     |    |
|       |   | A |                   |     |     |     |     |    |
|       |   | * |                   |     |     |     |     |    |
|       |   | * |                   |     |     |     |     |    |
+-------+---+---+-------------------+-----+-----+-----+-----+----+
| **A   | * | * | #### A/New        | **[ | **6 | **1 | **8 | ** |
| USTRA | * | * | Caledonia/20/99\* | \<] | 8** | 7** | 8** | 83 |
| LIA** | C | 2 |                   | {.u |     |     |     | ** |
|       | B | 4 | *                 | nde | *   | **2 | **9 |    |
| **ADU | E | * | *A/Belem/84066/03 | rli | *11 | 1** | 2** | ** |
| LTS** | R | * | (H1N2)**          | ne} | 7** |     |     | 88 |
|       | * |   |                   | 8** |     | **  | **8 | ** |
| **    | * |   | **A               |     | **5 | 5** | 3** |    |
| (2/20 |   |   | /Virginia/20/03** | **[ | 2** |     |     | ** |
| 04)** |   |   |                   | \<] |     |     |     | 88 |
|       |   |   |                   | {.u |     |     |     | ** |
|       |   |   |                   | nde |     |     |     |    |
|       |   |   |                   | rli |     |     |     |    |
|       |   |   |                   | ne} |     |     |     |    |
|       |   |   |                   | 8** |     |     |     |    |
|       |   |   |                   |     |     |     |     |    |
|       |   |   |                   | **[ |     |     |     |    |
|       |   |   |                   | \<] |     |     |     |    |
|       |   |   |                   | {.u |     |     |     |    |
|       |   |   |                   | nde |     |     |     |    |
|       |   |   |                   | rli |     |     |     |    |
|       |   |   |                   | ne} |     |     |     |    |
|       |   |   |                   | 8** |     |     |     |    |
+-------+---+---+-------------------+-----+-----+-----+-----+----+
| **EUR |   | * | #### A/New        | **[ | **2 | **  | **5 | ** |
| OPE** |   | * | Caledonia/20/99\* | \<] | 5** | 4** | 8** | 58 |
|       |   | 2 |                   | {.u |     |     |     | ** |
| #     |   | 4 | *                 | nde | **2 | **  | **5 |    |
| ##  A |   | * | *A/Belem/84066/03 | rli | 7** | 4** | 4** | ** |
| DULTS |   | * | (H1N2)**          | ne} |     |     |     | 67 |
|       |   |   |                   | 8** | **1 | **  | **5 | ** |
| **    |   |   | **A               |     | 8** | 0** | 0** |    |
| (2/20 |   |   | /Virginia/20/03** | **[ |     |     |     | ** |
| 04)** |   |   |                   | \<] |     |     |     | 58 |
|       |   |   |                   | {.u |     |     |     | ** |
|       |   |   |                   | nde |     |     |     |    |
|       |   |   |                   | rli |     |     |     |    |
|       |   |   |                   | ne} |     |     |     |    |
|       |   |   |                   | 8** |     |     |     |    |
|       |   |   |                   |     |     |     |     |    |
|       |   |   |                   | **[ |     |     |     |    |
|       |   |   |                   | \<] |     |     |     |    |
|       |   |   |                   | {.u |     |     |     |    |
|       |   |   |                   | nde |     |     |     |    |
|       |   |   |                   | rli |     |     |     |    |
|       |   |   |                   | ne} |     |     |     |    |
|       |   |   |                   | 8** |     |     |     |    |
+-------+---+---+-------------------+-----+-----+-----+-----+----+
| **JA  |   | * | #### A/New        | **[ | **1 | **1 | **3 | ** |
| PAN** |   | * | Caledonia/20/99\* | \<] | 6** | 6** | 2** | 48 |
|       |   | 2 |                   | {.u |     |     |     | ** |
| **ADU |   | 5 | *                 | nde | **1 | **1 | **4 |    |
| LTS** |   | * | *A/Belem/84066/03 | rli | 6** | 6** | 4** | ** |
|       |   | * | (H1N2)**          | ne} |     |     |     | 36 |
| **    |   |   |                   | 8** | **1 | **  | **2 | ** |
| (2/20 |   |   | **A               |     | 2** | 0** | 0** |    |
| 04)** |   |   | /Virginia/20/03** | **[ |     |     |     | ** |
|       |   |   |                   | \<] |     |     |     | 28 |
|       |   |   |                   | {.u |     |     |     | ** |
|       |   |   |                   | nde |     |     |     |    |
|       |   |   |                   | rli |     |     |     |    |
|       |   |   |                   | ne} |     |     |     |    |
|       |   |   |                   | 8** |     |     |     |    |
|       |   |   |                   |     |     |     |     |    |
|       |   |   |                   | **[ |     |     |     |    |
|       |   |   |                   | \<] |     |     |     |    |
|       |   |   |                   | {.u |     |     |     |    |
|       |   |   |                   | nde |     |     |     |    |
|       |   |   |                   | rli |     |     |     |    |
|       |   |   |                   | ne} |     |     |     |    |
|       |   |   |                   | 8** |     |     |     |    |
+-------+---+---+-------------------+-----+-----+-----+-----+----+
| **    |   | * | #### A/New        | **1 | **3 | **2 | **7 | ** |
| USA** |   | * | Caledonia/20/99\* | 1** | 9** | 0** | 5** | 40 |
|       |   | 2 |                   |     |     |     |     | ** |
| **ADU |   | 0 | *                 | **  | **4 | **2 | **7 |    |
| LTS** |   | * | *A/Belem/84066/03 | 9** | 5** | 0** | 5** | ** |
|       |   | * | (H1N2)**          |     |     |     |     | 50 |
| **    |   |   |                   | **  | **4 | **2 | **7 | ** |
| (2/20 |   |   | **A               | 9** | 4** | 0** | 0** |    |
| 04)** |   |   | /Virginia/20/03** |     |     |     |     | ** |
|       |   |   |                   |     |     |     |     | 50 |
|       |   |   |                   |     |     |     |     | ** |
+-------+---+---+-------------------+-----+-----+-----+-----+----+
|       |   |   | **\*** **Vaccine  |     |     |     |     |    |
|       |   |   | Strain**          |     |     |     |     |    |
+-------+---+---+-------------------+-----+-----+-----+-----+----+

**HEMAGGLUTINATION INHIBITION ANTIBODY TITERS TO INFLUENZA A (H1N1)
VIRUSES**

+-------+---+---+-------------------+-----+-----+-----+-----+----+
| **TR  | * | * | **VIRUS STRAIN**  | *   |     | **% |     | *  |
| IAL** | * | * |                   | *GM |     | [\> |     | *% |
|       | T | N |                   | T** |     | ]{. |     | 4  |
|       | E | O |                   |     |     | und |     | ** |
|       | S | . |                   | **  |     | erl |     |    |
|       | T | * |                   | PRE |     | ine |     | ** |
|       | * | * |                   | POS |     | }32 |     | FO |
|       | * |   |                   | T** |     | or4 |     | LD |
|       |   | * |                   |     |     | 0** |     | ** |
|       | * | * |                   |     |     |     |     |    |
|       | * | O |                   |     |     | **  |     | ** |
|       | S | F |                   |     |     | PRE |     | RI |
|       | I | * |                   |     |     | POS |     | SE |
|       | T | * |                   |     |     | T** |     | ** |
|       | E |   |                   |     |     |     |     |    |
|       | * | * |                   |     |     |     |     |    |
|       | * | * |                   |     |     |     |     |    |
|       |   | S |                   |     |     |     |     |    |
|       |   | E |                   |     |     |     |     |    |
|       |   | R |                   |     |     |     |     |    |
|       |   | A |                   |     |     |     |     |    |
|       |   | * |                   |     |     |     |     |    |
|       |   | * |                   |     |     |     |     |    |
+-------+---+---+-------------------+-----+-----+-----+-----+----+
| **A   | * | * | #### A/New        | **1 | **2 | **1 | **5 | ** |
| USTRA | * | * | Caledonia/20/99\* | 0** | 4** | 3** | 8** | 38 |
| LIA** | C | 2 |                   |     |     |     |     | ** |
|       | B | 4 | *                 | **2 | **3 | **5 | **7 |    |
| *     | E | * | *A/Belem/84066/03 | 0** | 5** | 4** | 5** | ** |
| *ELDE | R | * | (H1N2)**          |     |     |     |     | 33 |
| RLY** | * |   |                   | **1 | **3 | **3 | **8 | ** |
|       | * |   | **A               | 3** | 9** | 8** | 3** |    |
| **    |   |   | /Virginia/20/03** |     |     |     |     | ** |
| (2/20 |   |   |                   |     |     |     |     | 42 |
| 04)** |   |   |                   |     |     |     |     | ** |
+-------+---+---+-------------------+-----+-----+-----+-----+----+
| **EUR |   | * | #### A/New        | **[ | **  | **  | **1 | ** |
| OPE** |   | * | Caledonia/20/99\* | \<] | 9** | 4** | 7** | 25 |
|       |   | 2 |                   | {.u |     |     |     | ** |
| *     |   | 4 | *                 | nde | **1 | **  | **3 |    |
| *ELDE |   | * | *A/Belem/84066/03 | rli | 3** | 0** | 3** | ** |
| RLY** |   | * | (H1N2)**          | ne} |     |     |     | 38 |
|       |   |   |                   | 8** | **1 | **  | **1 | ** |
| **    |   |   | **A               |     | 0** | 4** | 7** |    |
| (2/20 |   |   | /Virginia/20/03** | **[ |     |     |     | ** |
| 04)** |   |   |                   | \<] |     |     |     | 29 |
|       |   |   |                   | {.u |     |     |     | ** |
|       |   |   |                   | nde |     |     |     |    |
|       |   |   |                   | rli |     |     |     |    |
|       |   |   |                   | ne} |     |     |     |    |
|       |   |   |                   | 8** |     |     |     |    |
|       |   |   |                   |     |     |     |     |    |
|       |   |   |                   | **[ |     |     |     |    |
|       |   |   |                   | \<] |     |     |     |    |
|       |   |   |                   | {.u |     |     |     |    |
|       |   |   |                   | nde |     |     |     |    |
|       |   |   |                   | rli |     |     |     |    |
|       |   |   |                   | ne} |     |     |     |    |
|       |   |   |                   | 8** |     |     |     |    |
+-------+---+---+-------------------+-----+-----+-----+-----+----+
| **JA  |   | * | #### A/New        | **[ | **[ | **  | **2 | ** |
| PAN** |   | * | Caledonia/20/99\* | \<] | \<] | 7** | 7** | 23 |
|       |   | 3 |                   | {.u | {.u |     |     | ** |
| *     |   | 0 | *                 | nde | nde | **1 | **3 |    |
| *ELDE |   | * | *A/Belem/84066/03 | rli | rli | 3** | 0** | ** |
| RLY** |   | * | (H1N2)**          | ne} | ne} |     |     | 23 |
|       |   |   |                   | 8** | 8** | **1 | **2 | ** |
| **    |   |   | **A               |     |     | 0** | 7** |    |
| (2/20 |   |   | /Virginia/20/03** | **[ | **  |     |     | ** |
| 04)** |   |   |                   | \<] | 9** |     |     | 30 |
|       |   |   |                   | {.u |     |     |     | ** |
|       |   |   |                   | nde | **[ |     |     |    |
|       |   |   |                   | rli | \<] |     |     |    |
|       |   |   |                   | ne} | {.u |     |     |    |
|       |   |   |                   | 8** | nde |     |     |    |
|       |   |   |                   |     | rli |     |     |    |
|       |   |   |                   | **[ | ne} |     |     |    |
|       |   |   |                   | \<] | 8** |     |     |    |
|       |   |   |                   | {.u |     |     |     |    |
|       |   |   |                   | nde |     |     |     |    |
|       |   |   |                   | rli |     |     |     |    |
|       |   |   |                   | ne} |     |     |     |    |
|       |   |   |                   | 8** |     |     |     |    |
+-------+---+---+-------------------+-----+-----+-----+-----+----+
| **    |   | * | #### A/New        | **[ | **1 | **1 | **4 | ** |
| USA** |   | * | Caledonia/20/99\* | \<] | 8** | 2** | 1** | 29 |
|       |   | 1 |                   | {.u |     |     |     | ** |
| *     |   | 7 | *                 | nde | **2 | **1 | **3 |    |
| *ELDE |   | * | *A/Belem/84066/03 | rli | 0** | 2** | 5** | ** |
| RLY** |   | * | (H1N2)**          | ne} |     |     |     | 47 |
|       |   |   |                   | 8** | **2 | **2 | **4 | ** |
| **    |   |   | **A               |     | 8** | 4** | 7** |    |
| (2/20 |   |   | /Virginia/20/03** | **[ |     |     |     | ** |
| 04)** |   |   |                   | \<] |     |     |     | 35 |
|       |   |   |                   | {.u |     |     |     | ** |
|       |   |   |                   | nde |     |     |     |    |
|       |   |   |                   | rli |     |     |     |    |
|       |   |   |                   | ne} |     |     |     |    |
|       |   |   |                   | 8** |     |     |     |    |
|       |   |   |                   |     |     |     |     |    |
|       |   |   |                   | **[ |     |     |     |    |
|       |   |   |                   | \<] |     |     |     |    |
|       |   |   |                   | {.u |     |     |     |    |
|       |   |   |                   | nde |     |     |     |    |
|       |   |   |                   | rli |     |     |     |    |
|       |   |   |                   | ne} |     |     |     |    |
|       |   |   |                   | 8** |     |     |     |    |
+-------+---+---+-------------------+-----+-----+-----+-----+----+
|       |   |   | **\* Vaccine      |     |     |     |     |    |
|       |   |   | Strain**          |     |     |     |     |    |
+-------+---+---+-------------------+-----+-----+-----+-----+----+

**HEMAGGLUTINATION INHIBITION ANTIBODY TITERS TO INFLUENZA A (H3N2)
VIRUSES**

+-------+----+----+------------------+-----+-----+-----+-----+----+
| **TR  | ** | ** | **VIRUS STRAIN** | *   |     | **% |     | *  |
| IAL** | TE | \# |                  | *GM |     | [\> |     | *4 |
|       | ST | SE |                  | T** |     | ]{. |     | ** |
|       | ** | RA |                  |     |     | und |     |    |
|       |    | ** |                  | **  |     | erl |     | ** |
|       | ** |    |                  | PRE |     | ine |     | FO |
|       | SI |    |                  | POS |     | }32 |     | LD |
|       | TE |    |                  | T** |     | or4 |     | ** |
|       | ** |    |                  |     |     | 0** |     |    |
|       |    |    |                  |     |     |     |     |    |
|       |    |    |                  |     |     | **  |     |    |
|       |    |    |                  |     |     | PRE |     |    |
|       |    |    |                  |     |     | POS |     |    |
|       |    |    |                  |     |     | T** |     |    |
+-------+----+----+------------------+-----+-----+-----+-----+----+
| **A   | ** | ** | **A/             | ### | #   | #   | #   | #  |
| USTRA | CB | 24 | Panama/2007/99** | # \ | ### | ### | ### | ## |
| LIA** | ER | ** |                  | <16 |  64 |  25 |  92 | #  |
|       | ** |    | *                |     |     |     |     | 63 |
| **ADU |    |    | *A/Texas/40/03** | *   | **3 | **2 | **8 |    |
| LTS** |    |    |                  | *[\ | 9** | 1** | 8** | ** |
|       |    |    | ###              | <]{ |     |     |     | 54 |
| **    |    |    |  A/Chile/8266/03 | .un | **8 | **5 | **8 | ** |
| (2/20 |    |    |                  | der | 8** | 4** | 8** |    |
| 04)** |    |    | **A/             | lin |     |     |     | ** |
|       |    |    | Fiujian/445/03** | e}1 | **7 | **3 | **8 | 46 |
|       |    |    |                  | 6** | 2** | 3** | 8** | ** |
|       |    |    | **A/V            |     |     |     |     |    |
|       |    |    | ictoria/584/03** | **2 | **7 | **3 | **9 | ** |
|       |    |    |                  | 1** | 8** | 8** | 6** | 46 |
|       |    |    | ##               |     |     |     |     | ** |
|       |    |    |  A/Texas/141/03  | **1 | **2 | **3 | **3 |    |
|       |    |    |                  | 8** | 4** | 3** | 8** | ** |
|       |    |    |                  |     |     |     |     | 63 |
|       |    |    |                  | **1 |     |     |     | ** |
|       |    |    |                  | 7** |     |     |     |    |
|       |    |    |                  |     |     |     |     | ** |
|       |    |    |                  | *   |     |     |     | 25 |
|       |    |    |                  | *[\ |     |     |     | ** |
|       |    |    |                  | <]{ |     |     |     |    |
|       |    |    |                  | .un |     |     |     |    |
|       |    |    |                  | der |     |     |     |    |
|       |    |    |                  | lin |     |     |     |    |
|       |    |    |                  | e}1 |     |     |     |    |
|       |    |    |                  | 6** |     |     |     |    |
+-------+----+----+------------------+-----+-----+-----+-----+----+
| **EUR |    | ** | **A/             | *   | #   | ### | #   | #  |
| OPE** |    | 24 | Panama/2007/99** | *[\ | ### | # 4 | ### | ## |
|       |    | ** |                  | <]{ |  18 |     |  42 | #  |
| **ADU |    |    | *                | .un |     | **  |     | 50 |
| LTS** |    |    | *A/Texas/40/03** | der | *   | 0** | **4 |    |
|       |    |    |                  | lin | *[\ |     | 2** | ** |
| **    |    |    | ###              | e}1 | <]{ | **  |     | 50 |
| (2/20 |    |    |  A/Chile/8266/03 | 6** | .un | 8** | **5 | ** |
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|       |    |    |                  | <]{ | 6** |     | 4** | ** |
|       |    |    | **A/V            | .un |     | **  |     |    |
|       |    |    | ictoria/584/03** | der | **2 | 4** | **4 | ** |
|       |    |    |                  | lin | 8** |     | 6** | 54 |
|       |    |    | ######           | e}1 |     | **  |     | ** |
|       |    |    |  A/Texas/141/03  | 6** | **2 | 8** | **2 |    |
|       |    |    |                  |     | 7** |     | 9** | ** |
|       |    |    |                  | *   |     |     |     | 33 |
|       |    |    |                  | *[\ | **2 |     |     | ** |
|       |    |    |                  | <]{ | 8** |     |     |    |
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|       |    |    |                  | der | *   |     |     | 21 |
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|       |    |    |                  | 6** |     |     |     |    |
+-------+----+----+------------------+-----+-----+-----+-----+----+
| **JA  |    | ** | **A/             | *   | #   | #   | #   | #  |
| PAN** |    | 25 | Panama/2007/99** | *[\ | ### | ### | ### | ## |
|       |    | ** |                  | <]{ |  17 |  16 |  40 | #  |
| **ADU |    |    | *                | .un |     |     |     | 20 |
| LTS** |    |    | *A/Texas/40/03** | der | *   | **  | **1 |    |
|       |    |    |                  | lin | *[\ | 8** | 6** | *  |
| **    |    |    | ###              | e}1 | <]{ |     |     | *4 |
| (2/20 |    |    |  A/Chile/8266/03 | 6** | .un | **2 | **5 | ** |
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|       |    |    | **A/             | *   | lin |     |     | ** |
|       |    |    | Fiujian/445/03** | *[\ | e}1 | **1 | **3 | 20 |
|       |    |    |                  | <]{ | 6** | 6** | 6** | ** |
|       |    |    | **A/V            | .un |     |     |     |    |
|       |    |    | ictoria/584/03** | der | **2 | **1 | **4 | ** |
|       |    |    |                  | lin | 3** | 2** | 0** | 12 |
|       |    |    | ######           | e}1 |     |     |     | ** |
|       |    |    |  A/Texas/141/03  | 6** | *   | **2 | **4 |    |
|       |    |    |                  |     | *[\ | 0** | 0** | ** |
|       |    |    |                  | *   | <]{ |     |     | 28 |
|       |    |    |                  | *[\ | .un |     |     | ** |
|       |    |    |                  | <]{ | der |     |     |    |
|       |    |    |                  | .un | lin |     |     | ** |
|       |    |    |                  | der | e}1 |     |     | 16 |
|       |    |    |                  | lin | 6** |     |     | ** |
|       |    |    |                  | e}1 |     |     |     |    |
|       |    |    |                  | 6** | **1 |     |     |    |
|       |    |    |                  |     | 7** |     |     |    |
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|       |    |    |                  | 6** |     |     |     |    |
+-------+----+----+------------------+-----+-----+-----+-----+----+
| **    |    | ** | **A/             | #   | #   | #   | #   | #  |
| USA** |    | 21 | Panama/2007/99** | ### | ### | ### | ### | ## |
|       |    | ** |                  |  27 |  64 |  67 |  81 | #  |
| **ADU |    |    | *                |     |     |     |     | 38 |
| LTS** |    |    | *A/Texas/40/03** | *   | **4 | **3 | **8 |    |
|       |    |    |                  | *[\ | 3** | 8** | 1** | ** |
| **    |    |    | ###              | <]{ |     |     |     | 29 |
| (2/20 |    |    |  A/Chile/8266/03 | .un | *   | **5 | **9 | ** |
| 04)** |    |    |                  | der | *12 | 7** | 5** |    |
|       |    |    | **A/             | lin | 9** |     |     | ** |
|       |    |    | Fiujian/445/03** | e}1 |     | **4 | **8 | 52 |
|       |    |    |                  | 6** | **7 | 3** | 1** | ** |
|       |    |    | **A/V            |     | 5** |     |     |    |
|       |    |    | ictoria/584/03** | **2 |     | **4 | **8 | ** |
|       |    |    |                  | 9** | **9 | 8** | 5** | 57 |
|       |    |    | ######           |     | 2** |     |     | ** |
|       |    |    |  A/Texas/141/03  | **2 |     | **3 | **5 |    |
|       |    |    |                  | 0** | **2 | 8** | 3** | ** |
|       |    |    |                  |     | 7** |     |     | 52 |
|       |    |    |                  | **2 |     |     |     | ** |
|       |    |    |                  | 4** |     |     |     |    |
|       |    |    |                  |     |     |     |     | ** |
|       |    |    |                  | **1 |     |     |     | 19 |
|       |    |    |                  | 7** |     |     |     | ** |
+-------+----+----+------------------+-----+-----+-----+-----+----+
|       |    |    | \***Vaccine      |     |     |     |     |    |
|       |    |    | Strain**         |     |     |     |     |    |
+-------+----+----+------------------+-----+-----+-----+-----+----+

**HEMAGGLUTINATION INHIBITION ANTIBODY TITERS TO INFLUENZA A (H3N2)
VIRUSES**

+-------+----+----+------------------+-----+-----+-----+-----+----+
| **TR  | ** | ** | **VIRUS STRAIN** | *   |     | **% |     | *  |
| IAL** | TE | \# |                  | *GM |     | [\> |     | *4 |
|       | ST | SE |                  | T** |     | ]{. |     | ** |
|       | ** | RA |                  |     |     | und |     |    |
|       |    | ** |                  | **  |     | erl |     | ** |
|       | ** |    |                  | PRE |     | ine |     | FO |
|       | SI |    |                  | POS |     | }32 |     | LD |
|       | TE |    |                  | T** |     | or4 |     | ** |
|       | ** |    |                  |     |     | 0** |     |    |
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|       |    |    |                  |     |     | POS |     |    |
|       |    |    |                  |     |     | T** |     |    |
+-------+----+----+------------------+-----+-----+-----+-----+----+
| **A   | ** | ** | **               | #   | #   | #   | #   | #  |
| USTRA | CB | 24 | A/Panama/2007/99 | ### | ### | ### | ### | ## |
| LIA** | ER | ** | RESVIR17\***     |  18 |  38 |  42 |  67 | #  |
|       | ** |    |                  |     |     |     |     | 17 |
| *     |    |    | *                | *   | **2 | **3 | **5 |    |
| *ELDE |    |    | *A/Texas/40/03** | *[\ | 8** | 3** | 8** | ** |
| RLY** |    |    |                  | <]{ |     |     |     | 25 |
|       |    |    | ###              | .un | **5 | **4 | **7 | ** |
| **    |    |    |  A/Chile/8266/03 | der | 9** | 6** | 1** |    |
| (2/20 |    |    |                  | lin |     |     |     | ** |
| 04)** |    |    | **A/             | e}1 | **4 | **3 | **6 | 33 |
|       |    |    | Fiujian/445/03** | 6** | 8** | 8** | 3** | ** |
|       |    |    |                  |     |     |     |     |    |
|       |    |    | **A/V            | **2 | **4 | **3 | **5 | ** |
|       |    |    | ictoria/584/03** | 1** | 4** | 8** | 8** | 25 |
|       |    |    |                  |     |     |     |     | ** |
|       |    |    | ######           | **2 | **3 | **3 | **6 |    |
|       |    |    |  A/Texas/141/03  | 0** | 0** | 3** | 7** | ** |
|       |    |    |                  |     |     |     |     | 25 |
|       |    |    |                  | **2 |     |     |     | ** |
|       |    |    |                  | 0** |     |     |     |    |
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|       |    |    |                  | *   |     |     |     | 29 |
|       |    |    |                  | *[\ |     |     |     | ** |
|       |    |    |                  | <]{ |     |     |     |    |
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|       |    |    |                  | e}1 |     |     |     |    |
|       |    |    |                  | 6** |     |     |     |    |
+-------+----+----+------------------+-----+-----+-----+-----+----+
| **JA  |    | ** | **               | *   | *   | #   | #   | #  |
| PAN** |    | 30 | A/Panama/2007/99 | *[\ | *[\ | ### | ### | ## |
|       |    | ** | RESVIR17\***     | <]{ | <]{ |  43 |  63 | #  |
| *     |    |    |                  | .un | .un |     |     | 23 |
| *ELDE |    |    | *                | der | der | **3 | **4 |    |
| RLY** |    |    | *A/Texas/40/03** | lin | lin | 7** | 0** | ** |
|       |    |    |                  | e}1 | e}1 |     |     | 20 |
| **    |    |    | ###              | 6** | 6** | **6 | **8 | ** |
| (2/20 |    |    |  A/Chile/8266/03 |     |     | 0** | 3** |    |
| 04)** |    |    |                  | *   | *   |     |     | ** |
|       |    |    | **A/             | *[\ | *[\ | **3 | **3 | 23 |
|       |    |    | Fiujian/445/03** | <]{ | <]{ | 7** | 7** | ** |
|       |    |    |                  | .un | .un |     |     |    |
|       |    |    | **A/V            | der | der | **4 | **5 | *  |
|       |    |    | ictoria/584/03** | lin | lin | 3** | 0** | *3 |
|       |    |    |                  | e}1 | e}1 |     |     | ** |
|       |    |    | ######           | 6** | 6** | **1 | **2 |    |
|       |    |    |  A/Texas/141/03  |     |     | 7** | 0** | *  |
|       |    |    |                  | *   | **1 |     |     | *3 |
|       |    |    |                  | *[\ | 8** |     |     | ** |
|       |    |    |                  | <]{ |     |     |     |    |
|       |    |    |                  | .un | *   |     |     | *  |
|       |    |    |                  | der | *[\ |     |     | *3 |
|       |    |    |                  | lin | <]{ |     |     | ** |
|       |    |    |                  | e}1 | .un |     |     |    |
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|       |    |    |                  | *[\ | 6** |     |     |    |
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|       |    |    |                  | 6** | der |     |     |    |
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|       |    |    |                  | *   | e}1 |     |     |    |
|       |    |    |                  | *[\ | 6** |     |     |    |
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|       |    |    |                  | e}1 | .un |     |     |    |
|       |    |    |                  | 6** | der |     |     |    |
|       |    |    |                  |     | lin |     |     |    |
|       |    |    |                  | *   | e}1 |     |     |    |
|       |    |    |                  | *[\ | 6** |     |     |    |
|       |    |    |                  | <]{ |     |     |     |    |
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|       |    |    |                  | e}1 |     |     |     |    |
|       |    |    |                  | 6** |     |     |     |    |
+-------+----+----+------------------+-----+-----+-----+-----+----+
| **    |    | ** | **               | #   | #   | #   | #   | #  |
| USA** |    | 21 | A/Panama/2007/99 | ### | ### | ### | ### | ## |
|       |    | ** | RESVIR17\***     |  28 |  48 |  67 |  95 | #  |
| *     |    |    |                  |     |     |     |     | 19 |
| *ELDE |    |    | *                | **2 | **2 | **4 | **7 |    |
| RLY** |    |    | *A/Texas/40/03** | 0** | 9** | 8** | 1** | ** |
|       |    |    |                  |     |     |     |     | 14 |
| **    |    |    | ###              | **3 | **8 | **6 | *   | ** |
| (2/20 |    |    |  A/Chile/8266/03 | 7** | 3** | 7** | *10 |    |
| 04)** |    |    |                  |     |     |     | 0** | ** |
|       |    |    | **A/             | **2 | **5 | **3 |     | 33 |
|       |    |    | Fiujian/445/03** | 4** | 6** | 8** | **8 | ** |
|       |    |    |                  |     |     |     | 1** |    |
|       |    |    | **A/V            | **3 | **6 | **4 |     | ** |
|       |    |    | ictoria/584/03** | 1** | 5** | 8** | **8 | 43 |
|       |    |    |                  |     |     |     | 6** | ** |
|       |    |    | ######           | **1 | **2 | **2 |     |    |
|       |    |    |  A/Texas/141/03  | 7** | 4** | 9** | **5 | ** |
|       |    |    |                  |     |     |     | 2** | 38 |
|       |    |    |                  |     |     |     |     | ** |
|       |    |    |                  |     |     |     |     |    |
|       |    |    |                  |     |     |     |     | *  |
|       |    |    |                  |     |     |     |     | *5 |
|       |    |    |                  |     |     |     |     | ** |
+-------+----+----+------------------+-----+-----+-----+-----+----+
|       |    |    | \***Vaccine      |     |     |     |     |    |
|       |    |    | Strain**         |     |     |     |     |    |
+-------+----+----+------------------+-----+-----+-----+-----+----+

**HEMAGGLUTINATION INHIBITION ANTIBODY TITERS TO INFLUENZA B VIRUSES**

+--------+-----+---+---------------+---+------+------+------+------+
| **T    | **  | * | **VIRUS       | * |      | **%  |      | **%  |
| RIAL** | TES | * | STRAIN**      | * |      | [\>] |      | 4**  |
|        | T** | N |               | G |      | {.un |      |      |
|        |     | O |               | M |      | derl |      | **FO |
|        | **  | . |               | T |      | ine} |      | LD** |
|        | SIT | * |               | * |      | 32or |      |      |
|        | E** | * |               | * |      | 40** |      | **RI |
|        |     |   |               |   |      |      |      | SE** |
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|        |     | O |               | P |      | PO   |      |      |
|        |     | F |               | R |      | ST** |      |      |
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+--------+-----+---+---------------+---+------+------+------+------+
| *      | **  | * | #### B/Sha    | # | ###  | ###  | ###  | ###  |
| *AUSTR | CBE | * | ndong/07/97\* | # | # 64 | # 17 | # 92 | # 79 |
| ALIA** | R** | 2 |               | # |      |      |      |      |
|        |     | 4 | **B/Hong      | # | **   | *    | **   | **   |
| **AD   |     | * | K             |   | 87** | *8** | 92** | 88** |
| ULTS** |     | * | ong/1434/02** | \ |      |      |      |      |
|        |     |   |               | < | **   | *    | **   | **   |
| **(2/2 |     |   | **B/Sic       | 8 | 49** | *8** | 79** | 75** |
| 004)** |     |   | huan/259/03** |   |      |      |      |      |
|        |     |   |               | * | **   | **   | **   | **   |
|        |     |   | **B/          | * | 64** | 46** | 75** | 50** |
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|        |     |   |               | * |      |      |      |      |
|        |     |   |               |   |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               | 1 |      |      |      |      |
|        |     |   |               | 9 |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
+--------+-----+---+---------------+---+------+------+------+------+
| **EU   |     | * | #### B/Sha    | # | ###  | ##   | ###  | ###  |
| ROPE** |     | * | ndong/07/97\* | # | # 17 | ## 0 | # 46 | # 46 |
|        |     | 2 |               | # |      |      |      |      |
| **AD   |     | 4 | **B/Hong      | # | **   | *    | **   | **   |
| ULTS** |     | * | K             |   | 18** | *0** | 46** | 54** |
|        |     | * | ong/1434/02** | \ |      |      |      |      |
| **(2/2 |     |   |               | < | **   | *    | **   | **   |
| 004)** |     |   | **B/Sic       | 8 | 19** | *0** | 46** | 54** |
|        |     |   | huan/259/03** |   |      |      |      |      |
|        |     |   |               | * | *    | *    | **   | **   |
|        |     |   | **B/          | * | *[\< | *8** | 38** | 38** |
|        |     |   | Jilin/20/03** | [ | ]{.u |      |      |      |
|        |     |   |               | \ | nder |      |      |      |
|        |     |   |               | < | line |      |      |      |
|        |     |   |               | ] | }8** |      |      |      |
|        |     |   |               | { |      |      |      |      |
|        |     |   |               | . |      |      |      |      |
|        |     |   |               | u |      |      |      |      |
|        |     |   |               | n |      |      |      |      |
|        |     |   |               | d |      |      |      |      |
|        |     |   |               | e |      |      |      |      |
|        |     |   |               | r |      |      |      |      |
|        |     |   |               | l |      |      |      |      |
|        |     |   |               | i |      |      |      |      |
|        |     |   |               | n |      |      |      |      |
|        |     |   |               | e |      |      |      |      |
|        |     |   |               | } |      |      |      |      |
|        |     |   |               | 8 |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               |   |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               | [ |      |      |      |      |
|        |     |   |               | \ |      |      |      |      |
|        |     |   |               | < |      |      |      |      |
|        |     |   |               | ] |      |      |      |      |
|        |     |   |               | { |      |      |      |      |
|        |     |   |               | . |      |      |      |      |
|        |     |   |               | u |      |      |      |      |
|        |     |   |               | n |      |      |      |      |
|        |     |   |               | d |      |      |      |      |
|        |     |   |               | e |      |      |      |      |
|        |     |   |               | r |      |      |      |      |
|        |     |   |               | l |      |      |      |      |
|        |     |   |               | i |      |      |      |      |
|        |     |   |               | n |      |      |      |      |
|        |     |   |               | e |      |      |      |      |
|        |     |   |               | } |      |      |      |      |
|        |     |   |               | 8 |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               |   |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               | [ |      |      |      |      |
|        |     |   |               | \ |      |      |      |      |
|        |     |   |               | < |      |      |      |      |
|        |     |   |               | ] |      |      |      |      |
|        |     |   |               | { |      |      |      |      |
|        |     |   |               | . |      |      |      |      |
|        |     |   |               | u |      |      |      |      |
|        |     |   |               | n |      |      |      |      |
|        |     |   |               | d |      |      |      |      |
|        |     |   |               | e |      |      |      |      |
|        |     |   |               | r |      |      |      |      |
|        |     |   |               | l |      |      |      |      |
|        |     |   |               | i |      |      |      |      |
|        |     |   |               | n |      |      |      |      |
|        |     |   |               | e |      |      |      |      |
|        |     |   |               | } |      |      |      |      |
|        |     |   |               | 8 |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
+--------+-----+---+---------------+---+------+------+------+------+
| **J    |     | * | #### B/Sha    | # | #### | ###  | ###  | ###  |
| apan** |     | * | ndong/07/97\* | # |  \<8 | # 32 | # 52 | # 12 |
|        |     | 2 |               | # |      |      |      |      |
| **AD   |     | 5 | **B/Hong      | # | **   | **   | **   | **   |
| ULTS** |     | * | Kon           |   | 18** | 36** | 52** | 32** |
|        |     | * | g/1434/02\*** | \ |      |      |      |      |
| **(2/2 |     |   |               | < | **   | **   | **   | **   |
| 004)** |     |   | **B/Sic       | 8 | 19** | 33** | 56** | 24** |
|        |     |   | huan/259/03** |   |      |      |      |      |
|        |     |   |               | * | **   | **   | **   | **   |
|        |     |   | **B/          | * | 28** | 48** | 60** | 16** |
|        |     |   | Jilin/20/03** | [ |      |      |      |      |
|        |     |   |               | \ |      |      |      |      |
|        |     |   |               | < |      |      |      |      |
|        |     |   |               | ] |      |      |      |      |
|        |     |   |               | { |      |      |      |      |
|        |     |   |               | . |      |      |      |      |
|        |     |   |               | u |      |      |      |      |
|        |     |   |               | n |      |      |      |      |
|        |     |   |               | d |      |      |      |      |
|        |     |   |               | e |      |      |      |      |
|        |     |   |               | r |      |      |      |      |
|        |     |   |               | l |      |      |      |      |
|        |     |   |               | i |      |      |      |      |
|        |     |   |               | n |      |      |      |      |
|        |     |   |               | e |      |      |      |      |
|        |     |   |               | } |      |      |      |      |
|        |     |   |               | 8 |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               |   |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               | [ |      |      |      |      |
|        |     |   |               | \ |      |      |      |      |
|        |     |   |               | < |      |      |      |      |
|        |     |   |               | ] |      |      |      |      |
|        |     |   |               | { |      |      |      |      |
|        |     |   |               | . |      |      |      |      |
|        |     |   |               | u |      |      |      |      |
|        |     |   |               | n |      |      |      |      |
|        |     |   |               | d |      |      |      |      |
|        |     |   |               | e |      |      |      |      |
|        |     |   |               | r |      |      |      |      |
|        |     |   |               | l |      |      |      |      |
|        |     |   |               | i |      |      |      |      |
|        |     |   |               | n |      |      |      |      |
|        |     |   |               | e |      |      |      |      |
|        |     |   |               | } |      |      |      |      |
|        |     |   |               | 8 |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               |   |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               | 1 |      |      |      |      |
|        |     |   |               | 8 |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
+--------+-----+---+---------------+---+------+------+------+------+
| *      |     | * | #### B/S      | # | ###  | ##   | ###  | ###  |
| *USA** |     | * | handong/07/97 | # | # 42 | ## 5 | # 71 | # 71 |
|        |     | 2 |               | # |      |      |      |      |
| **AD   |     | 1 | **B/Hong      | # | **   | *    | **   | **   |
| ULTS** |     | * | Kon           |   | 71** | *5** | 86** | 86** |
|        |     | * | g/1434/02\*** | \ |      |      |      |      |
| **(2/2 |     |   |               | < | **   | *    | **   | **   |
| 004)** |     |   | **B/Sic       | 8 | 57** | *5** | 81** | 76** |
|        |     |   | huan/259/03** |   |      |      |      |      |
|        |     |   |               | * | **   | **   | **   | **   |
|        |     |   | **B/          | * | 71** | 43** | 85** | 43** |
|        |     |   | Jilin/20/03** | [ |      |      |      |      |
|        |     |   |               | \ |      |      |      |      |
|        |     |   |               | < |      |      |      |      |
|        |     |   |               | ] |      |      |      |      |
|        |     |   |               | { |      |      |      |      |
|        |     |   |               | . |      |      |      |      |
|        |     |   |               | u |      |      |      |      |
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|        |     |   |               | i |      |      |      |      |
|        |     |   |               | n |      |      |      |      |
|        |     |   |               | e |      |      |      |      |
|        |     |   |               | } |      |      |      |      |
|        |     |   |               | 8 |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               |   |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               | [ |      |      |      |      |
|        |     |   |               | \ |      |      |      |      |
|        |     |   |               | < |      |      |      |      |
|        |     |   |               | ] |      |      |      |      |
|        |     |   |               | { |      |      |      |      |
|        |     |   |               | . |      |      |      |      |
|        |     |   |               | u |      |      |      |      |
|        |     |   |               | n |      |      |      |      |
|        |     |   |               | d |      |      |      |      |
|        |     |   |               | e |      |      |      |      |
|        |     |   |               | r |      |      |      |      |
|        |     |   |               | l |      |      |      |      |
|        |     |   |               | i |      |      |      |      |
|        |     |   |               | n |      |      |      |      |
|        |     |   |               | e |      |      |      |      |
|        |     |   |               | } |      |      |      |      |
|        |     |   |               | 8 |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               |   |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               | 1 |      |      |      |      |
|        |     |   |               | 8 |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
+--------+-----+---+---------------+---+------+------+------+------+
|        |     |   | **\*Vaccine   |   |      |      |      |      |
|        |     |   | Strain**      |   |      |      |      |      |
+--------+-----+---+---------------+---+------+------+------+------+

###  

### HEMAGGLUTINATION INHIBITION ANTIBODY TITERS TO INFLUENZA B VIRUSES 

+--------+-----+---+----------------+---+------+------+------+------+
| **T    | **  | * | **VIRUS        | * |      | **%  |      | **%  |
| RIAL** | TES | * | STRAIN**       | * |      | [\>] |      | 4**  |
|        | T** | N |                | G |      | {.un |      |      |
|        |     | O |                | M |      | derl |      | **FO |
|        | **  | . |                | T |      | ine} |      | LD** |
|        | SIT | * |                | * |      | 32or |      |      |
|        | E** | * |                | * |      | 40** |      | **RI |
|        |     |   |                |   |      |      |      | SE** |
|        |     | * |                | * |      | *    |      |      |
|        |     | * |                | * |      | *PRE |      |      |
|        |     | O |                | P |      | PO   |      |      |
|        |     | F |                | R |      | ST** |      |      |
|        |     | * |                | E |      |      |      |      |
|        |     | * |                | P |      |      |      |      |
|        |     |   |                | O |      |      |      |      |
|        |     | * |                | S |      |      |      |      |
|        |     | * |                | T |      |      |      |      |
|        |     | S |                | * |      |      |      |      |
|        |     | E |                | * |      |      |      |      |
|        |     | R |                |   |      |      |      |      |
|        |     | A |                |   |      |      |      |      |
|        |     | * |                |   |      |      |      |      |
|        |     | * |                |   |      |      |      |      |
+--------+-----+---+----------------+---+------+------+------+------+
| *      | **  | * | #### B/Sh      | # | ###  | ##   | ###  | ###  |
| *AUSTR | CBE | * | andong/07/97\* | # | # 30 | ## 8 | # 67 | # 67 |
| ALIA** | R** | 2 |                | # |      |      |      |      |
|        |     | 4 | **B/Hong       | # | **   | *    | **   | **   |
| **ELD  |     | * | Kong/1434/02** |   | 43** | *8** | 97** | 79** |
| ERLY** |     | * |                | \ |      |      |      |      |
|        |     |   | **B/Si         | < | **   | *    | **   | **   |
| **(2/2 |     |   | chuan/259/03** | 8 | 21** | *8** | 58** | 58** |
| 004)** |     |   |                |   |      |      |      |      |
|        |     |   | **B            | * | **   | **   | **   | **   |
|        |     |   | /Jilin/20/03** | * | 51** | 29** | 79** | 46** |
|        |     |   |                | [ |      |      |      |      |
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|        |     |   |                | 8 |      |      |      |      |
|        |     |   |                | * |      |      |      |      |
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|        |     |   |                | \ |      |      |      |      |
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|        |     |   |                | 8 |      |      |      |      |
|        |     |   |                | * |      |      |      |      |
|        |     |   |                | * |      |      |      |      |
|        |     |   |                |   |      |      |      |      |
|        |     |   |                | * |      |      |      |      |
|        |     |   |                | * |      |      |      |      |
|        |     |   |                | [ |      |      |      |      |
|        |     |   |                | \ |      |      |      |      |
|        |     |   |                | < |      |      |      |      |
|        |     |   |                | ] |      |      |      |      |
|        |     |   |                | { |      |      |      |      |
|        |     |   |                | . |      |      |      |      |
|        |     |   |                | u |      |      |      |      |
|        |     |   |                | n |      |      |      |      |
|        |     |   |                | d |      |      |      |      |
|        |     |   |                | e |      |      |      |      |
|        |     |   |                | r |      |      |      |      |
|        |     |   |                | l |      |      |      |      |
|        |     |   |                | i |      |      |      |      |
|        |     |   |                | n |      |      |      |      |
|        |     |   |                | e |      |      |      |      |
|        |     |   |                | } |      |      |      |      |
|        |     |   |                | 8 |      |      |      |      |
|        |     |   |                | * |      |      |      |      |
|        |     |   |                | * |      |      |      |      |
+--------+-----+---+----------------+---+------+------+------+------+
| **EU   |     | * | #### B/Sh      | # | #### | ##   | ###  | ###  |
| ROPE** |     | * | andong/07/97\* | # |   11 | ## 4 | # 26 | # 38 |
|        |     | 2 |                | # |      |      |      |      |
| **ELD  |     | 4 | **B/Hong       | # | **   | *    | **   | **   |
| ERLY** |     | * | Kong/1434/02** |   | 12** | *4** | 33** | 42** |
|        |     | * |                | \ |      |      |      |      |
| **(2/2 |     |   | **B/Si         | < | **   | *    | **   | **   |
| 004)** |     |   | chuan/259/03** | 8 | 14** | *4** | 38** | 46** |
|        |     |   |                |   |      |      |      |      |
|        |     |   | **B            | * | **   | **   | **   | **   |
|        |     |   | /Jilin/20/03** | * | 11** | 21** | 33** | 21** |
|        |     |   |                | [ |      |      |      |      |
|        |     |   |                | \ |      |      |      |      |
|        |     |   |                | < |      |      |      |      |
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|        |     |   |                | 8 |      |      |      |      |
|        |     |   |                | * |      |      |      |      |
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|        |     |   |                | * |      |      |      |      |
|        |     |   |                | [ |      |      |      |      |
|        |     |   |                | \ |      |      |      |      |
|        |     |   |                | < |      |      |      |      |
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|        |     |   |                | { |      |      |      |      |
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|        |     |   |                | 8 |      |      |      |      |
|        |     |   |                | * |      |      |      |      |
|        |     |   |                | * |      |      |      |      |
+--------+-----+---+----------------+---+------+------+------+------+
| **J    |     | * | #### B/Sh      | # | ###  | ###  | ###  | ###  |
| APAN** |     | * | andong/07/97\* | # | #  9 | # 30 | # 37 | # 10 |
|        |     | 3 |                | # |      |      |      |      |
| **ELD  |     | 0 | **B/Hong       | # | **   | **   | **   | *    |
| ERLY** |     | * | Ko             |   | 10** | 43** | 50** | *3** |
|        |     | * | ng/1434/02\*** | \ |      |      |      |      |
| **(2/2 |     |   |                | < | *    | **   | **   | *    |
| 004)** |     |   | **B/Si         | 8 | *9** | 43** | 37** | *7** |
|        |     |   | chuan/259/03** |   |      |      |      |      |
|        |     |   |                | * | *    | **   | **   | *    |
|        |     |   | **B            | * | *[\< | 23** | 23** | *3** |
|        |     |   | /Jilin/20/03** | [ | 8]{. |      |      |      |
|        |     |   |                | \ | unde |      |      |      |
|        |     |   |                | < | rlin |      |      |      |
|        |     |   |                | ] | e}** |      |      |      |
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|        |     |   |                | * |      |      |      |      |
|        |     |   |                | * |      |      |      |      |
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|        |     |   |                | * |      |      |      |      |
|        |     |   |                | * |      |      |      |      |
|        |     |   |                | [ |      |      |      |      |
|        |     |   |                | \ |      |      |      |      |
|        |     |   |                | < |      |      |      |      |
|        |     |   |                | ] |      |      |      |      |
|        |     |   |                | { |      |      |      |      |
|        |     |   |                | . |      |      |      |      |
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|        |     |   |                | n |      |      |      |      |
|        |     |   |                | d |      |      |      |      |
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|        |     |   |                | i |      |      |      |      |
|        |     |   |                | n |      |      |      |      |
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|        |     |   |                | 8 |      |      |      |      |
|        |     |   |                | * |      |      |      |      |
|        |     |   |                | * |      |      |      |      |
+--------+-----+---+----------------+---+------+------+------+------+
| *      |     | * | #### B/        | # | ###  | ##   | ###  | ###  |
| *USA** |     | * | Shandong/07/97 | # | # 56 | ## 5 | # 62 | # 62 |
|        |     | 2 |                | # |      |      |      |      |
| **ELD  |     | 1 | **B/Hong       | # | **   | **   | **   | **   |
| ERLY** |     | * | Ko             |   | 51** | 10** | 48** | 76** |
|        |     | * | ng/1434/02\*** | \ |      |      |      |      |
| **(2/2 |     |   |                | < | **   | **   | **   | **   |
| 004)** |     |   | **B/Si         | 8 | 45** | 10** | 48** | 57** |
|        |     |   | chuan/259/03** |   |      |      |      |      |
|        |     |   |                | * | **   | **   | **   | **   |
|        |     |   | **B            | * | 58** | 33** | 62** | 29** |
|        |     |   | /Jilin/20/03** | [ |      |      |      |      |
|        |     |   |                | \ |      |      |      |      |
|        |     |   |                | < |      |      |      |      |
|        |     |   |                | ] |      |      |      |      |
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|        |     |   |                | 8 |      |      |      |      |
|        |     |   |                | * |      |      |      |      |
|        |     |   |                | * |      |      |      |      |
|        |     |   |                |   |      |      |      |      |
|        |     |   |                | * |      |      |      |      |
|        |     |   |                | * |      |      |      |      |
|        |     |   |                | [ |      |      |      |      |
|        |     |   |                | \ |      |      |      |      |
|        |     |   |                | < |      |      |      |      |
|        |     |   |                | ] |      |      |      |      |
|        |     |   |                | { |      |      |      |      |
|        |     |   |                | . |      |      |      |      |
|        |     |   |                | u |      |      |      |      |
|        |     |   |                | n |      |      |      |      |
|        |     |   |                | d |      |      |      |      |
|        |     |   |                | e |      |      |      |      |
|        |     |   |                | r |      |      |      |      |
|        |     |   |                | l |      |      |      |      |
|        |     |   |                | i |      |      |      |      |
|        |     |   |                | n |      |      |      |      |
|        |     |   |                | e |      |      |      |      |
|        |     |   |                | } |      |      |      |      |
|        |     |   |                | 8 |      |      |      |      |
|        |     |   |                | * |      |      |      |      |
|        |     |   |                | * |      |      |      |      |
|        |     |   |                |   |      |      |      |      |
|        |     |   |                | * |      |      |      |      |
|        |     |   |                | * |      |      |      |      |
|        |     |   |                | 2 |      |      |      |      |
|        |     |   |                | 3 |      |      |      |      |
|        |     |   |                | * |      |      |      |      |
|        |     |   |                | * |      |      |      |      |
+--------+-----+---+----------------+---+------+------+------+------+
|        |     |   | **\*Vaccine    |   |      |      |      |      |
|        |     |   | Strain**       |   |      |      |      |      |
+--------+-----+---+----------------+---+------+------+------+------+

HEMAGGLUTINATION INHIBITION ANTIBODY TITERS: 2001-2002 VACCINES

+--------+-----+---+---------------+---+------+------+------+------+
| **T    | **  | * | **VIRUS       | * |      | **%  |      | **%  |
| RIAL** | TES | * | STRAIN**      | * |      | [\>] |      | 4**  |
|        | T** | N |               | G |      | {.un |      |      |
|        |     | O |               | M |      | derl |      | **FO |
|        | **  | . |               | T |      | ine} |      | LD** |
|        | SIT | * |               | * |      | 32or |      |      |
|        | E** | * |               | * |      | 40** |      | **RI |
|        |     |   |               |   |      |      |      | SE** |
|        |     | * |               | * |      | *    |      |      |
|        |     | * |               | * |      | *PRE |      |      |
|        |     | O |               | P |      | PO   |      |      |
|        |     | F |               | R |      | ST** |      |      |
|        |     | * |               | E |      |      |      |      |
|        |     | * |               | P |      |      |      |      |
|        |     |   |               | O |      |      |      |      |
|        |     | * |               | S |      |      |      |      |
|        |     | * |               | T |      |      |      |      |
|        |     | S |               | * |      |      |      |      |
|        |     | E |               | * |      |      |      |      |
|        |     | R |               |   |      |      |      |      |
|        |     | A |               |   |      |      |      |      |
|        |     | * |               |   |      |      |      |      |
|        |     | * |               |   |      |      |      |      |
+--------+-----+---+---------------+---+------+------+------+------+
| *      | **  | * | **B/Victor    | # | #### | ###  | ###  | ###  |
| *USA** | CBE | * | ia/504/00\*** | # |  157 | # 75 | # 93 | # 13 |
|        | R** | 1 |               | # |      |      |      |      |
| **AD   |     | 6 | **B/Sic       | # | **   | **   | **   | **   |
| ULTS** |     | * | huan/259/03** |   | 16** | 31** | 50** | 31** |
|        |     | * |               | 6 |      |      |      |      |
| **(2/2 |     |   | **B/          | 4 | **   | **   | **   | **   |
| 004)** |     |   | Jilin/20/03** |   | 76** | 50** | 88** | 31** |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               | [ |      |      |      |      |
|        |     |   |               | \ |      |      |      |      |
|        |     |   |               | < |      |      |      |      |
|        |     |   |               | ] |      |      |      |      |
|        |     |   |               | { |      |      |      |      |
|        |     |   |               | . |      |      |      |      |
|        |     |   |               | u |      |      |      |      |
|        |     |   |               | n |      |      |      |      |
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|        |     |   |               | e |      |      |      |      |
|        |     |   |               | } |      |      |      |      |
|        |     |   |               | 8 |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               |   |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               | 3 |      |      |      |      |
|        |     |   |               | 0 |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
+--------+-----+---+---------------+---+------+------+------+------+
| *      |     | * | **B/Victor    | # | ###  | ###  | ###  | ###  |
| *USA** |     | * | ia/504/00\*** | # | # 31 | # 47 | # 60 | # 20 |
|        |     | 1 |               | # |      |      |      |      |
| **ELD  |     | 5 | **B/Sic       | # | **   | **   | **   | **   |
| ERLY** |     | * | huan/259/03** |   | 12** | 13** | 27** | 20** |
|        |     | * |               | 1 |      |      |      |      |
| **(2/2 |     |   | **B/          | 8 | **   | **   | **   | *    |
| 004)** |     |   | Jilin/20/03** |   | 24** | 47** | 53** | *0** |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               | [ |      |      |      |      |
|        |     |   |               | \ |      |      |      |      |
|        |     |   |               | < |      |      |      |      |
|        |     |   |               | ] |      |      |      |      |
|        |     |   |               | { |      |      |      |      |
|        |     |   |               | . |      |      |      |      |
|        |     |   |               | u |      |      |      |      |
|        |     |   |               | n |      |      |      |      |
|        |     |   |               | d |      |      |      |      |
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|        |     |   |               | r |      |      |      |      |
|        |     |   |               | l |      |      |      |      |
|        |     |   |               | i |      |      |      |      |
|        |     |   |               | n |      |      |      |      |
|        |     |   |               | e |      |      |      |      |
|        |     |   |               | } |      |      |      |      |
|        |     |   |               | 8 |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               |   |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               | 2 |      |      |      |      |
|        |     |   |               | 1 |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
|        |     |   |               | * |      |      |      |      |
+--------+-----+---+---------------+---+------+------+------+------+
|        |     |   | **\*Vaccine   |   |      |      |      |      |
|        |     |   | Strain**      |   |      |      |      |      |
+--------+-----+---+---------------+---+------+------+------+------+

PEDIATRIC HEMAGGLUTINATION INHIBITION ANTIBODY TITERS TO INFLUENZA
VIRUSES

+-------+---+-------+----------------+-----+------+-----+----+----+
| **TR  | * | **NO. | **VIRUS        | *   |      | **% |    | *  |
| IAL** | * | OF**  | STRAIN**       | *GM |      | [\> |    | *% |
|       | T |       |                | T** |      | ]{. |    | 4  |
|       | E | **S   |                |     |      | und |    | ** |
|       | S | ERA** |                | **  |      | erl |    |    |
|       | T |       |                | PRE |      | ine |    | ** |
|       | * |       |                | POS |      | }32 |    | FO |
|       | * |       |                | T** |      | or4 |    | LD |
|       |   |       |                |     |      | 0** |    | ** |
|       | * |       |                |     |      |     |    |    |
|       | * |       |                |     |      | **  |    | ** |
|       | S |       |                |     |      | PRE |    | RI |
|       | I |       |                |     |      | POS |    | SE |
|       | T |       |                |     |      | T** |    | ** |
|       | E |       |                |     |      |     |    |    |
|       | * |       |                |     |      |     |    |    |
|       | * |       |                |     |      |     |    |    |
+-------+---+-------+----------------+-----+------+-----+----+----+
| **P   | * | *     | #### A/New Cal | ##  | ###  | #   | #  | #  |
| EDIAT | * | *30** | edonia/20/99\* | ##  | # 25 | ### | ## | ## |
| RIC** | C |       |                | \<8 |      |  10 | #  | #  |
|       | B |       | **A/           |     | **   |     | 50 | 80 |
|       | E |       | Belem/84066/03 | **[ | 39** | **1 |    |    |
|       | R |       | (H1N2)**       | \<] |      | 0** | ** | ** |
|       | * |       |                | {.u | **   |     | 63 | 83 |
|       | * |       | **A/Vi         | nde | 34** | **1 | ** | ** |
|       |   |       | rginia/20/03** | rli |      | 0** |    |    |
|       |   |       |                | ne} |      |     | ** | ** |
|       |   |       |                | 8** |      |     | 77 | 93 |
|       |   |       |                |     |      |     | ** | ** |
|       |   |       |                | **[ |      |     |    |    |
|       |   |       |                | \<] |      |     |    |    |
|       |   |       |                | {.u |      |     |    |    |
|       |   |       |                | nde |      |     |    |    |
|       |   |       |                | rli |      |     |    |    |
|       |   |       |                | ne} |      |     |    |    |
|       |   |       |                | 8** |      |     |    |    |
+-------+---+-------+----------------+-----+------+-----+----+----+
| **P   |   | *     | **A/Pana       | ##  | ###  | #   | #  | #  |
| EDIAT |   | *31** | ma/2007/99\*** | ##  | # 40 | ### | ## | ## |
| RIC** |   |       |                | \<8 |      |  10 | #  | #  |
|       |   |       | **A/Kum        |     | **   |     | 58 | 87 |
| **    |   |       | amoto/102/02** | **[ | 31** | **1 |    |    |
| (2/20 |   |       |                | \<] |      | 3** | ** | ** |
| 04)** |   |       | ### A          | {.u | **   |     | 61 | 74 |
|       |   |       | /Wyoming/03/03 | nde | 13** | **1 | ** | ** |
|       |   |       |                | rli |      | 0** |    |    |
|       |   |       | **A/Hong       | ne} | **   |     | ** | ** |
|       |   |       | Kong/1186/03** | 8** | 11** | **1 | 16 | 39 |
|       |   |       |                |     |      | 0** | ** | ** |
|       |   |       | ##             | **[ |      |     |    |    |
|       |   |       |                | \<] |      |     | ** | ** |
|       |   |       |                | {.u |      |     | 13 | 32 |
|       |   |       |                | nde |      |     | ** | ** |
|       |   |       |                | rli |      |     |    |    |
|       |   |       |                | ne} |      |     |    |    |
|       |   |       |                | 8** |      |     |    |    |
|       |   |       |                |     |      |     |    |    |
|       |   |       |                | **[ |      |     |    |    |
|       |   |       |                | \<] |      |     |    |    |
|       |   |       |                | {.u |      |     |    |    |
|       |   |       |                | nde |      |     |    |    |
|       |   |       |                | rli |      |     |    |    |
|       |   |       |                | ne} |      |     |    |    |
|       |   |       |                | 8** |      |     |    |    |
+-------+---+-------+----------------+-----+------+-----+----+----+
| **P   |   | *     | #### B/Sh      | ##  | ###  | ### | #  | #  |
| EDIAT |   | *30** | andong/07/97\* | ##  | # 21 | # 3 | ## | ## |
| RIC** |   |       |                | \<8 |      |     | #  | #  |
|       |   |       | **B/Hong       |     | **   | **  | 57 | 77 |
|       |   |       | Ko             | **[ | 31** | 0** |    |    |
|       |   |       | ng/1434/02\*** | \<] |      |     | ** | ** |
|       |   |       |                | {.u | **   | **  | 75 | 83 |
|       |   |       | **B/Si         | nde | 26** | 0** | ** | ** |
|       |   |       | chuan/259/03** | rli |      |     |    |    |
|       |   |       |                | ne} | *    | **  | ** | ** |
|       |   |       | **B            | 8** | *[\< | 0** | 67 | 80 |
|       |   |       | /Jilin/20/03** |     | ]{.u |     | ** | ** |
|       |   |       |                | **[ | nder |     |    |    |
|       |   |       |                | \<] | line |     | *  | *  |
|       |   |       |                | {.u | }8** |     | *3 | *7 |
|       |   |       |                | nde |      |     | ** | ** |
|       |   |       |                | rli |      |     |    |    |
|       |   |       |                | ne} |      |     |    |    |
|       |   |       |                | 8** |      |     |    |    |
|       |   |       |                |     |      |     |    |    |
|       |   |       |                | **[ |      |     |    |    |
|       |   |       |                | \<] |      |     |    |    |
|       |   |       |                | {.u |      |     |    |    |
|       |   |       |                | nde |      |     |    |    |
|       |   |       |                | rli |      |     |    |    |
|       |   |       |                | ne} |      |     |    |    |
|       |   |       |                | 8** |      |     |    |    |
+-------+---+-------+----------------+-----+------+-----+----+----+
|       |   | **    | **\*Vaccine    |     |      |     |    |    |
|       |   | Range | Strain**       |     |      |     |    |    |
|       |   | 8-38  |                |     |      |     |    |    |
|       |   | (Mont |                |     |      |     |    |    |
|       |   | hs)** |                |     |      |     |    |    |
|       |   |       |                |     |      |     |    |    |
|       |   | *     |                |     |      |     |    |    |
|       |   | *Mean |                |     |      |     |    |    |
|       |   | 21**  |                |     |      |     |    |    |
+-------+---+-------+----------------+-----+------+-----+----+----+

**CONTRIBUTING PERSONNEL**

**CENTER FOR BIOLOGICS EVALUATION AND RESEARCH**

**BETHESDA, MARYLAND**

**TERESA LIU, M.S.**

**JONATHAN MCINNIS**

# CARYN STRUPCZEWSKI

**GALINA VODEIKO, PH.D.**

**ZHIPING YE, M.D., PH.D.**

**ROLAND A. LEVANDOWSKI, M.D.**