BEE-spoke-data/govdocs1-by-extension huggingface dataset:
**The molecular ecology of Guerrero Negro: justifying the need for
environmental genomics**

Jason M. Smith

*Soil and Water Science Department*

*University of Florida*

*2169 McCarty Hall, Gainesville, FL 32611*

*USA*

jmsmith@ifas.ufl.edu

Stefan J. Green

*Exobiology Branch*

*NASA Ames Research Center*

*M/S 239-4, Moffett Field, CA 94035*

*USA*

Pia Moisander

*Ocean Sciences Department*

*University of California-Santa Cruz*

*1156 High St, Santa Cruz, CA 95064*

*USA*

Kathryn J. Roberts

*Department of Geological and Environmental Sciences*

*Stanford University*

*Stanford, CA 94305*

*USA*

Chris Francis

*Department of Geological and Environmental Sciences*

*Stanford University*

*Stanford, CA 94305*

*USA*

Leslie Prufert-Bebout

*Exobiology Branch*

*NASA Ames Research Center*

*M/S 239-4, Moffett Field, CA 94035*

*USA*

Brad M. Bebout

*Exobiology Branch*

*NASA Ames Research Center*

*M/S 239-4, Moffett Field, CA 94035*

*USA*

The record of life on the only planet where it is known to exist is
contained in the biogeochemical processes that organisms catalyze for
their survival, in the compounds that they produce, and in their
phylogenetic (evolutionary) relationships to each other. We manipulated
sulfate and nutrient concentrations in intact microbial mats over
periods of time up to a year. The objectives of the manipulations
were: 1) characterize the diversity of process-associated functional
genes; 2) understand environmental conditions leading to shifts in
microbial guilds; 3) monitor/identify competitive responses of organisms
sharing a metabolic niche. Characterization of functional genes
associated with carbon (*mcrA*), nitrogen (*nifH*, *nirK*) and sulfur
(*dsrAB)* cycling performed to date provided insight into the diversity
and metabolic potential of the system; however, we only identified broad
scale correlations between gene abundances and changes in mat
physiology. For instance, increases in methane production by mats
subjected to lowered sulfate and salinity concentrations were correlated
with an observed increase in abundance of hydrogenotroph-like *mcrA*
genes. However, due to low sequence similarity to any cultured isolates,
phylogenetic associations only allow order level taxonomic commentary,
preventing any associations being made on the cellular level. In each of
the genes characterized from these experiments, a significant portion of
sequences recovered show minimal phylogenetic affiliation to cultured
organisms, preventing any understanding of inter-community dynamics and
the functional capacities of these unknown organisms. Environmental
genomics may provide insight into mat systems by allowing the
correlation of functional genes with phylogenetic markers.
![](media/image1.png)

Laboratory-associated ergonomic risk factors are similar to those found
in the office and general industry and consist of: awkward and static
postures, high repetition, excessive force, contact stresses, vibration,
lifting and pinch grip among others. The following information offers
tips to identify and control ergonomic risks factors, improve level of
comfort while performing lab tasks and reduce the risk of
musculoskeletal discomfort and injury.

**Pipette Use:** highly repetitive lab procedure and could result affect
lab workers pipetting two hours a day or longer on a continuous basis.
Ergonomic risk factors and preventive measures include:

**Microscopy:** operating a microscope for long hours can put much
strain on the neck, shoulders, eyes, lower back and arms/wrists.
Ergonomic risk factors and preventive measures include:

**Lab Work Benches:** most work benches are fixed height and were
designed for light to slightly heavy work. Using a lab workbench as a
computer workstation could be a mismatch if it forces the worker to
assume a variety of awkward postures.

**Manual Tasks:** hand tool use and lifting of heavy equipment can
potentially cause excessive pinch forces, soft tissue contact pressure
and musculoskeletal strain if not properly managed.

For further ergonomics assistance or consultation, please contact
Jeffrey Chung at x5818 or <JYChung@lbl.gov>
U.S. REP. PATRICK T. MCHENRY

 

FOR IMMEDIATE RELEASE

21 APRIL 2005

CONTACT: JONATHAN COLLEGIO

\(202\) 225-2576

 

Congressman McHenry Introduces Legislation to Increase Penalties on Meth
Production and Trafficking in the Presence of Kids

*Bill would double the maximum prison time for criminals who produce or
transport methamphetamines*

*in the presence of children.*

 

WASHINGTON -- Congressman Patrick McHenry (R-NC-10) has introduced new
legislation aimed to curb methamphetamines production and trade. The
bill, H.R. 1616, would double the maximum jail time from 10 to 20 years
for those convicted of producing or trafficking methamphetamines or
other illegal drugs in the presence of children.

 

The bill comes as the result of a February 23^rd^, 2005 meeting
organized by Congressman McHenry in Lenoir, NC. McHenry, who is
vice-chairman of the House Government Reform Subcommittee on Criminal
Justice and Drug Policy, invited sheriffs from 7 western North Carolina
counties, officials from the U.S. Drug Enforcement Agency (DEA) and
North Carolina State Bureau of Investigation (SBI), and various local
narcotics officers to discuss solutions to the methamphetamines
epidemic.

 

"First and foremost, we must protect our children from illegal drugs,"
said Congressman McHenry. "This bill is common sense approach advocated
by local sheriffs and drug enforcement officials that will double the
maximum penalties for anyone who produces or traffics methamphetamines
in the presence of kids."

 

Congressman McHenry's bill was immediately cosponsored by 12 members of
Congress from all parts of the United States.

 

Methamphetamines and the clandestine labs used in its production
represent a growing problem in North Carolina. The Director of the
Office of National Drug Control Policy stated in 1998 that meth had
become the United States' primary drug threat.  Since then, meth
production has increased all over the country. 

 

The most innocent victims of the meth problem are children who are
exposed to labs run out of their homes by parents, caretakers, or
guardians.  An on-going study initiated in 2003 indicates that meth and
chemical contamination permeates every room of a home or structure where
a meth lab is operating. Children exposed to meth chemicals are at an
immediate risk of headaches, nausea and dizziness, and more chronic
exposure may lead to cancer along with damage to the brain, liver,
kidneys, spleen and immune system.

 

In 2004 alone, over 2,700 children were found in methamphetamines labs
seized by law enforcement officials -- amounting to an astounding 34%
presence in total seizures.
#  **Memorandum**

Date May 5, 2000

From Jerome E. Dennis, Electronic Products Branch

DOE III, OC, CDRH

Subject Amendments to the Laser Standard -- TEPRSSC Briefing Materials

To Dr. Orhan Suleiman

The materials consist of the draft of the amendments being developed for
proposal and that tables of accessible emission limits that will be a
part of the amendments to be proposed. The draft is still incomplete but
is up to date as of this date. Tables still remain to be completed and
then we will follow with an editorial review. The preamble presenting
our rationale to the new elements of the proposal and the analysis of
comments to the prior proposal remains to be written. The document is in
a three-column format for ease of comparison between the present
regulation, the amendments proposed in 1999 and the revision in process.
Because of the complexity and sizes of their files, I have not included
the tables that I have completed for the revision. We are retaining the
structure and organization of the present CDRH standard since we have
received many compliments over the years about its clarity.

Please make sure that the attached are drafts that represent our
considerations at this time. They should not be considered as official.
They can best be described as an attempt to incorporate some of the
concepts from the Final Draft IEC standard into the format of the CDRH
standard.

At its last meeting, TEPRSSC urged that we move with all due haste to
make the requirements of our standard the same as those of the IEC
standards (especially if it appears that the proposed amendments to the
IEC 60825-1 will be approved), but that we should not adopt any of the
IEC requirements that are unnecessarily restrictive or inappropriate,
such as the expansion of the scope to include light emitting diodes
(LEDs).

The new draft proposal does contain some new concepts based on inputs
received over the last few years. These include:

-   Redefinition of the criterion for human access to laser radiation
    that is only an ocular hazard to mean only the capability of direct
    eye exposure,

-   Establishment of a class limit for laser products promoted or sold
    as toys or novelty items,

-   Adoption of the new classifications, 1, 1M, 2, 2M, 3R, 3B and 4, of
    the IEC amendments,

-   Incorporation into the standard of the existing requirement for
    specific authorization by the Department of Defense for lasers
    intended for combat, combat training or are classified in national
    defense interests that may be exempted from certain requirements of
    the CDRH standard, and

-   Revision of the requirements for service instructions to clarify
    that the intent of the requirement is limited to radiation safety
    procedures during servicing

The status of the amendments to IEC 60825-1 is that the Committee Draft
for Vote (CDV) was approved with only one dissenting vote. The Technical
Committee at its meeting in Milan in November approved issuance of a
Final Draft International Standard (FIDS) for vote. That voting document
is expected almost immediately. If approved as expected, the amended
standard may be published in late August of this year.
![](media/image1.png){width="2.2472222222222222in"
height="0.6208333333333333in"}

January 19, 2006

Update on Academy Changes

Dear NFHTA Participants,

Effective immediately, there is no longer a HUD contract with the City
Center Hotel (formerly the Wyndham). Individuals are responsible for
finding their own hotels and paying the bill. You can find lodging by
using internet services like Hotels.com, Travelocity, or expedia.com.
HUD will issue specific guidance on this subject shortly.

The City Center Hotel will honor any reservations currently made at the
prevailing rates. Sunday orientations have been discontinued.

The Academy office and classrooms are now at the Howard University'
Miner Building (Building 14) at 2565 Georgia Avenue NW. If traveling by
taxicab, you may want the driver to approach the building from the 6^th^
Street NW side to avoid most of the steps. If needed, there is an ADA
lift for access into the building.

If trainees travel by subway, the closest stop is Howard University on
the Green Line. When initially boarding the train, get a transfer to use
on the Metro bus number 70 or 71. The bus will bring you the up the hill
for the additional six blocks and stops in front of the building.

Orientations start on Mondays at 8:30 a.m. in the Miner Auditorium. At
this session you will receive your classroom assignment and locations.

Please contact us if you have any questions or need further assistance.
You can reach us by email at: <nfhta@yahoo.com>. The office numbers are
202/865-0119 or 865-0117; the fax number is 202/986-3768. (Please bear
with us until we get voicemail and just keep trying.)

We apologize for any inconveniences you may have experienced.

Sincerely,

Beverly L. Watts

Director, NFHTA
**July 4, 2008**

**RE:          9 CFR Part 2 \[Docket No. APHIS-2006-0024\] RIN
0579-AC14\
               PR:  Minimum Age Requirements for the Transport of
Animalsµ\
\
**United States Department of Agriculture\
Animal and Plant Health Inspection Service\
Regulatory Analysis and Development\
PPD, APHIS, Station 3A-03.8\
4700 River Road Unit 118\
Riverdale, MD 20737-1238\
\
To Whom It May Concern:\
\
I am writing in support of the above referenced PROPOSED RULE (PR) to
amend the Animal Welfare Act regulations by adding minimum age
requirements for the transport in commerce of animals.   We are aware
that the current regulations address age limits for dogs and cats, but
that no corresponding regulations exist for ferrets. \
\
I agree and strongly support your proposal to amend the current
regulations to restrict the transport of ferrets that are less than 8
weeks of age, unless certain conditions have been met, as outlined in
the PR for both the domestic ferret (*Mustela putorius furo)* and the
wild black-footed ferret (*Mustela nigripes*), establishing federal
minimum age requirements for the transport in commerce of ferrets, and
providing for the transport of animals that have not met the minimum age
of 8 weeks of age, are necessary to help ensure the humane treatment of
these animals.\
\
Sincerely,

Monica Ennaciri

6461 Empty Song Rd

Columbia, Md 21044
![](media/image1.jpeg){width="1.95in" height="1.3125in"}

**[Rep. Sam Johnson Named Free Enterprise Legislator of the Year By
Associated Builders and Contractors]{.smallcaps}**

Contact: Gail Raiman, 703-812-2073 For Immediate Release

Scott Brown, 703-812-2062 June 9, 2004

WASHINGTON, DC \-- Associated Builders and Contractors (ABC) today named
U.S. Rep. Sam Johnson (R-Texas), chairman of the House Committee on
Education and the Workforce's Subcommittee on Employer-Employee
Relations, as the association's Free Enterprise Legislator of the Year.

Each year, ABC honors a member of Congress during its Legislative
Conference whose service to the public parallels the ideals upon which
ABC was founded: the principles of full and open competition and the
advancement of the free market system.

"Chairman Johnson's strong support for merit shop construction is
obvious," said Carole L. Bionda, ABC 2004 national chair. "Last summer
and again this spring, Chairman Johnson helped secure approval of
legislation that would allow association health plans (AHPs), one of
ABC's top priorities. He has also authored and advocated for legislation
that would ban project labor agreements, and has held hearings to shed
light on salting abuse and union violence."

Johnson was first elected to the House of Representatives in 1991.
Johnson spent nearly seven years as a prisoner of war in Vietnam after
his F-4 fighter plane was shot down in 1966. Upon his return to the
U.S., Johnson established a successful home-building business and served
in the Texas legislature.

More than 400 ABC members from across the nation are in Washington,
D.C., June 8-9, to attend ABC's 2004 Legislative Conference, which will
feature presentations by numerous top-ranking members of Congress.

\###

*Editors Note:* Associated Builders and Contractors (ABC) is a national
association representing 23,000 merit shop construction and
construction-related firms in 80 chapters across the United States. For
more news and information, visit ABC's website, www.abc.org.
NASA is pursuing innovative technologies and concepts as part of
America's Vision for Space Exploration. The rapidly emerging field of
nanotechnology has led to new concepts for multipurpose shields to
prevent catastrophic loss of vehicles and crew against the triple
threats of aeroheating during atmospheric entry, radiation (Solar and
galactic cosmic rays) and Micrometorid/Orbital Debris (MMOD) strikes.
The Thermophysics Facilities Branch of the Space Technology Division at
NASA Ames Research Center provides testing services for the development
and validation of the present and future concepts being developed by
NASA and national and International research firms. The Branch operates
two key facilities - the Range Complex and the Arc Jets. The Ranges
include both the Ames Vertical Gun Range (AVGR) and the Hypervelocity
Free Flight (HFF) gas guns best suited for MMOD investigations. Test
coupons can be installed in the AVGR or HFF and subjected to particle
impacts from glass or metal particles from micron to ¼ inch (6.35-mm)
diameters and at velocities from 5 to 8 km/s. The facility can record
high-speed data on film and provide damage assessment for analysis by
the Principle Investigator or Ames personnel. Damaged articles can be
installed in the Arc Jet facility for further testing to quantify the
effects of damage on the heat shield's performance upon entry into
atmospheric environments.
**Pink Ash Blankets Area Near Halema\`uma\`u After Third Explosion**

Early Wednesday morning, April 16, a small explosion occurred in
Halema\`uma\`u Crater. It was the third time the gas vent that opened in
mid-March blasted rocks or ash onto the crater rim. Seismic signals put
the time of the explosion at 3:57 a.m. USGS scientists are monitoring
Kīlauea's summit around the clock, but their view of the vent was
obscured by fog and mist at the time of the explosion.

Don Swanson, a Hawaiian Volcano Observatory geologist, was in the field
after first light and described the explosion debris as faintly pink
lithic ash (pulverized rock) with particles no more than 4 mm (0.2
inches) in diameter. This "rock dust" was observed on the crater rim
above the vent and downwind across the Halema\`uma\`u Overlook parking
area and a section of Crater Rim Drive. Closer examination of the ash
under a microscope revealed tiny volcanic glass fragments, indicating
that molten lava was also ejected in the explosion.

![](media/image1.jpeg){width="5.33125in" height="3.998611111111111in"}

*A USGS vehicle traveling on Crater Rim Drive near Halema\`uma\`u Crater
creates tracks in*

*the thin layer of pink ash ejected in the April 16 explosion.*
**FOR IMMEDIATE RELEASE: FOR INFORMATION CONTACT:**

May 26, 2005 Darlene Bresson - (605) 886-8202\
Tammi Schone - (605) 352-1102

**[USDA RURAL DEVELOPMENT ANNOUNCES BROOKINGS OFFICE DAY]{.underline}**

**WATERTOWN --** The USDA Rural Development office in Watertown, which
serves Brookings, Clark, Codington, Deuel, Grant, Hamlin and Kingsbury
Counties, has announced an office day will be held on June 6, 2005 in
Brookings, at the USDA Service Center, 205 -- 6^th^ Street, from 9:00
a.m. until 3:00 p.m. A loan officer will be present with information and
applications for most programs. Pre-qualification for housing loans will
also be offered.

USDA Rural Development programs assist rural families and communities in
a variety of ways. Support efforts include:

-   Housing Programs -- buy, build and repair homes.

-   Utilities Programs -- support water, waste, electric, and
    telecommunication projects.

-   Business and Community Programs -- community facilities projects,
    planning and assistance to businesses and cooperatives.

For additional information on our programs or to set up an appointment,
please contact the Watertown USDA Rural Development office at (605)
886-8202, Extension 4.

USDA Rural Development's mission is to deliver programs in a way that
will support increasing economic opportunity and improve the quality of
life of rural residents. As a venture capital entity, Rural Development
provides equity and technical assistance to finance and foster growth in
homeownership, business development, and critical community and
technology infrastructure. Further information on rural programs is
available at a local USDA Rural Development office or by visiting USDA's
web site at <http://www/rurdev.usda.gov>.

**- USDA -**

#
Desert Managers Group

**[Oct 2003]{.smallcaps}**

# Research Database Contact List

  ---------------------------------------------------------------------------------------
  **Name**       **Organization**      **Phone**         **E-Mail**
  -------------- --------------------- ----------------- --------------------------------
  Boerner, Eric  MDEP                  760-255-8806      webmaster@mojavedata.gov

  Cotterell,     BLM PSS CFO           760-251-4800      g.colterell@ca.blm.gov
  Gary                                                   

  Faull, Mark    CSP -- Mojave         661-942-0662      mfaull@parks.ca.gov

  Foremon, Larry BLM -- CDD            909-697-5200      lforemon@ca.blm.gov

  Greene, Linda  Death Valley NP       760-786-3253      Linda_greene@nps.gov

  Hohman, Judy   FWS                   805-644-1766      Judy_hohman@fws.gov

  Hughson, Debra Mojave                760-255-8801      Debra_Hughson@nps.gov

  Joia, Manny    MCLB Barstow          760-577-6111      joiam@Barstow.usmc.mil

  Jones, Becky   CDFG                  661-285-5867      dfgpalm@mindspring.com

  Knauf, Chris   BLM El Centro         760-337-4457      cknauf@ca.blm.gov

  Parker, Bob    BLM Ridgecrest        760-384-5400      robertparker@ca.blm.gov

  Quillman,      DPW Env. Div. Ft.     760-380-3740      Mickey.quillman@Irwin.army.mil
  Mickey         Irwin                                   

  Steckel, David Edwards AFB           661-277-1474      David.steckel@Edwards.af.mil

  Sullivan,      BLM Barstow           760-252-6000      
  Charles III                                            

  Wilson,        Joshua Tree           760-367-5561      Christine_Wilson@nps.gov
  Christine                                              
  ---------------------------------------------------------------------------------------
> ![](media/image1.png){width="8.494444444444444in" height="1.125in"}
>
> **United States Department of Agriculture Rural Development in Maine
> 967 Illinois Ave, Suite 4**

**Bangor, ME 04402-0405 Voice (207) 990-9160 Email:
<Emily.Cannon@me.usda.gov>**

**Web: www.rurdev.usda.gov/me**

CONTACT:

Emily Cannon (207) 990-9175

Rural Development, Public Affairs

**\$6.2 MILLION AVAILABLE TO INVEST IN RURAL\
ECONOMIC AND COMMUNITY DEVELOPMENT**

BANGOR, Maine, February 22, 2008− Agriculture Secretary Ed Schafer has
announced the availability of \$6.2 million nationwide for rural
community capacity building.

The Rural Community Development Initiative helps community-based
development organizations, federally recognized Indian tribes and other
groups promote economic growth in low-income, rural communities.
Recipients are required to obtain matching funds, doubling the value of
the grants. The public or nonprofit intermediary organizations then
provide funds to recipients to undertake projects related to housing,
community facilities, and community and economic development projects.

USDA Rural Development State Director Michael W. Aube said "The Rural
Community Development Initiative assists rural communities in expanding
important programs that lead to more opportunities and a better way of
life for their residents."

Eligible applicants include private or public organizations and Indian
Tribes that have been legally organized for a minimum of three years and
have experience working with the recipients eligible for this program.
Dollar-for-dollar matching funds are required. Applications must be
received no later than May 5, 2008. For more information, visit
<http://www.rurdev.usda.gov/rhs/rcdi/index.htm> or contact Ronald C.
Lambert, Community Programs Director, at 990-9121 or
<ronald.lambert@me.usda.gov>.

USDA Rural Development's mission is to increase economic opportunity and
improve the quality of life for rural residents. Rural Development has
invested nearly \$91 billion since 2001 for equity and technical
assistance to finance and foster growth in homeownership, business
development, and critical community and technology infrastructure. More
than 1.7 million jobs have been created or saved through these
investments. Further information on rural programs is available at a
local USDA Rural Development office or by visiting USDA's web site at
<http://www.rurdev.usda.gov/me>.

\#
+----------------------------------------+-----------------------------+
| ## Geomorphic Characteriza             |                             |
| tion Equipment and Supplies Checklist  |                             |
|                                        |                             |
| > Notebook                             |                             |
| >                                      |                             |
| > Base map(s)                          |                             |
| >                                      |                             |
| > Tape measures                        |                             |
| >                                      |                             |
| > Shovels                              |                             |
| >                                      |                             |
| > Soil knife                           |                             |
| >                                      |                             |
| > Nails                                |                             |
| >                                      |                             |
| > Pin flags                            |                             |
| >                                      |                             |
| > Flagging tape                        |                             |
| >                                      |                             |
| > Compass                              |                             |
| >                                      |                             |
| > Pruning shears                       |                             |
| >                                      |                             |
| > Ruler                                |                             |
| >                                      |                             |
| > Wooden Stakes                        |                             |
| >                                      |                             |
| > Clip Board                           |                             |
| >                                      |                             |
| > Rock Hammer                          |                             |
| >                                      |                             |
| > Sharpie                              |                             |
+----------------------------------------+-----------------------------+
| ER-SOP-03.08, R1                       | Los Alamos                  |
|                                        |                             |
|                                        | Environmental Restoration   |
|                                        | Project                     |
+----------------------------------------+-----------------------------+
Bibliography

Advisory Committee for Pharmaceutical Science

**November 3-4, 2004**

# Day 1: Wednesday, November 3, 2004

## **Topic 1 Pharmacogenetics of Irinotecan: Scientific and Clinical Impact of UGT Polymorphism**

1.  Background information

2.  Beutler E et al. Racial variability in the
    UDP-glucuronosyltransferase 1 (UGT1A1) promoter: A balanced
    polymorphism for regulation of bilirubin metabolism? Proc. Natl.
    Acad. Sci 1998; 95:8170-8174.

3.  Innocenti F et al. Genetic variants in the
    UDP-glucuronasyltransferase 1A1 gene predict the risk of severe
    neutropenia of irinotecan. J Clin Oncol 2004; 22(8); 1382-1388.

4.  Rouits E et al. Relevance of different UGT1A1 polymorphisms in
    irinotecan-induced toxicity: a molecular and clinical study of 75
    patients. Clin Cancer Res 2004; 10:5151-5159.

5.  Marcuello E et al. UGT1A1 gene variations and irinotecan treatment
    in patients with metastatic colorectal cancer. British J Cancer
    2004; 91:678-682.

6.  Iyer L et al. UGT1A1\*28 polymorphism as a determinant of irinotecan
    disposition and toxicity. Pharmacogenomics J 2002; 2:43-47.

7.  Ando Y et al. Polymorphisms of UDP-glucuronosyl-transferase gene and
    irinotecan toxicity: A pharmacogenetic analysis. Cancer Res. 2000;
    60:6921-6926.

**Topic 2: Drug-Drug Interaction Concept Paper: Issues Related to
Transporter- and Induction-Based Interactions and Multiple Inhibitor
Drug Interaction Studies**

1.  Concept paper" Drug interaction studies- Study Design, Data
    Analysis, and Implications for Dosing and Labeling

2.  Tucker G, Houston JB, and Huang S-M, Optimizing drug development:
    strategies to assess drug metabolism/transporter interaction
    potential- toward a consensus, Clin Pharmacol Ther. 2001
    Aug;70(2):103-14; Br J Clin Pharmacol. 2001 Jul;52(1):107-17; , Eur
    J Pharm Sci. 2001 Jul;13(4):417-28; Pharm Res. 2001
    Aug;18(8):1071-80.

3.  Bjorrnsson TD, Callaghan JT, Einolf HJ, Fischer V, Gan L, Grimm S,
    et al, The Conduct Of In Vitro And In Vivo Drug-Drug Interaction
    Studies: A Pharmaceutical Research and Manufacturers of America
    (Phrma) Perspective, Drug Metab Disp 31: 815-832, 2003

4.  Huang, S-M, Hall, SD, Watkins, P, Love, LA, Serabjit-Singh, C, Betz,
    et al, Drug Interactions with Herbal Products & Grapefruit Juice: A
    Conference Report, Clin Pharmacol Ther 2004 Jan;75(1):1-12

5.  Huang, S-M, Lesko, LJ, Drug-drug, drug-dietary supplement and
    drug-citrus fruit and other food interactions- what have we learned?
    J Clin Pharmacol 2004 Jun;44(6):559-69

# Day 2: Thursday, November 4, 2004

## **Topic 3 Transition of Biomarkers to Surrogate Endpoints: A New Critical Path Initiative**

1.  Lesko LJ, Atkinson, AJ, Use Of Biomarkers And Surrogate Endpoints In
    Drug Development and Regulatory Decision Making, Annu. Rev.
    Pharmacol. Toxicol. 2001. 41:347--66

2.  "Challenge and Opportunity on the Critical Path to New Medical
    Products\". FDA white paper available on the FDA Website:
    <http://www.fda.gov/oc/initiatives/criticalpath/>
**TASK DESCRIPTION**

Period covered: 3/31/2008-8/01/2008 -- Dr. Inigo Ruiz de Azua

Contractor should issue 4 subsistence checks @ \$1000.00 for a total of
\$4,000.00 to Dr. Inigo Ruiz de Azua. Adherence to the US Tax Laws as
applicable to foreign visitors, Social Security Number or TIN Number
will be provided either during the above time period or upon departure
from appointment.

Please forward the checks to:

Beverley Todd

NIH/NIDDK

10 Center Drive

Building 10, Room 9S207

Bethesda, MD 20892
**IRAQ FREEDOM FUND**

**FY 2008 Global War on Terror Request**

(This page intentionally left blank)

**IRAQI FREEDOM FUND (IFF)**

**Global War on Terror (GWOT)/Regional War on Terror (RWOT)**

**[Detail by Subactivity Group]{.underline}**

**Iraq Freedom Fund (IFF)**

**Operations -- Transportation of Human Remains**

**FY 2007 FY 2008**

**[Title IX/Supplemental]{.underline} [GWOT Request]{.underline}**

**355,600 107,500**

**Narrative Justification:** Section 562 of the John Warner National
Defense Authorization for FY 2007 requires the Department to provide
escorted transportation of military members who die in a combat zone.
Continuous escort and provision of an honor guard detail are required
from Dover Air Force Base to the final destination of the remains. The
request funds the dedicated airlift to support this requirement.

**IRAQI FREEDOM FUND (IFF)**

**Global War on Terror (GWOT)/Regional War on Terror (RWOT)**

**[Detail by Subactivity Group]{.underline}**

**Iraq Freedom Fund (IFF)**

**Operations -- Restart of Iraqi Factories, Task Force to Support
Business Stabilization Operations -- Iraq (TF BSOI)**

**FY 2007 FY 2008**

**[Title IX/Supplemental]{.underline} [GWOT Request]{.underline}**

**50,000 ~~0~~ 100,000**

**Narrative Justification:** The state of the Iraqi economy, to include
the extremely high unemployment rate, is a big cause of the discontent
that is fueling the insurgency. Economic stabilization is the best way
to reduce tensions. Reemploying idle Iraqis will lessen focus on strife.
TF BSOI utilized the \$50M provided by the Congress in FY07 for the
first Factory Revitalization efforts providing significant benefit to
over 30 factories and their related service providers. Iraqi officials
are eager to expand this effort. The TFBSOI's industrial restart effort
has produced substantial results already, and the impact curve is still
on the rise. This request funds the next stage efforts for the
reindustrialization of Iraq, providing job opportunities for Iraqis,
critical elements for improving the political and economic situation in
Iraq, which in turn will decrease the level of insurgency and enable the
Iraqi government to achieve the conditions needed for the United States
to reduce its role in Iraq.

(This page intentionally left blank.)
SOME_POLAR_MAGNETOPAUSE_CROSSINGS.DOC

By F.S. Mozer

June, 2002

The following tabulation gives times and locations of a selected group
of near sub-solar magnetopause crossings by the Polar Satellite. Of
approximately 1000 such crossings in Spring, 2001 and 2002, these have
been selected based on a cursory search of cases where B~Z~ in the
sheath was negative, and where, in many cases, the density did not
change greatly across the magnetopause.

Date UT Duration MLT Mlat Comment

3/4/2001 0430:40 5 sec 1330 12.1

3/4/2001 0432:50 10 sec 1330 12.2

3/4/2001 1948:00 60 sec 1320 16.4 5 xngs in 10 minutes

3/8/2001 1840:30 15 sec 1320 35.9

3/8/2001 1842:50 10 sec 1330 36.0

3/19/2001 1139:43 2 sec 1310 35.7

3/20/2001 0123:20 15 sec 1220 9.9

3/20/2001 0158:00 200 sec 1200 11.3

3/20/2001 0215:30 100 sec 1220 12.2

3/20/2001 0327:30 15 sec 1220 15.8

3/20/2001 1805:40 20 sec 1220 17.7

3/20/2001 1815:55 10 sec 1220 18.5

3/20/2001 1829:40 20 sec 1220 19.6

3/20/2001 1859:00 10 sec 1220 21.5

3/23/2001 0139:10 5 sec 1210 6.2

3/23/2001 0230:00 40 sec 1210 8.7

3/23/2001 0231:30 30 sec 1210 8.7

3/23/2001 0333:20 15 sec 1210 12.1

3/27/2001 1617:00 50 sec 1200 27.5

3/27/2001 1619:00 80 sec 1200 27.6

3/27/2001 1624:50 3 sec 1200 28.1

3/28/2001 0804:10 40 sec 1150 -2.3

3/29/2001 0524:30 7 sec 1200 9.3

3/29/2001 0541:00 20 sec 1200 10.7

3/30/2001 2133:30 10 sec 1140 39.7

3/30/2001 2134:30 20 sec 1140 39.7

4/1/2001 0520:40 30 sec 1140 3.3

4/1/2001 0530:10 140 sec 1140 4.2

4/1/2001 0534:10 30 sec 1140 4.6

4/1/2001 0547:10 30 sec 1140 5.8 The textbook example

4/1/2001 0552:30 20 sec 1140 6.2

4/1/2001 0557:30 5 sec 1150 6.8

4/1/2001 0606:00 120 sec 1150 7.5

4/1/2001 0613:10 60 sec 1150 8.3

4/1/2001 0616:00 150 sec 1140 8.5

4/1/2001 0721:00 120 sec 1150 14.9

4/1/2001 2034:30 5 sec 1130 30.6

4/1/2001 2311:30 30 sec 1140 9.4

4/1/2001 2323:50 10 sec 1140 9.9

4/2/2001 0021:20 30 sec 1140 12.1

4/2/2001 0024:30 15 sec 1140 12.2

4/2/2001 0110:40 6 sec 1140 14.1

4/2/2001 0139:30 10 sec 1140 15.4

4/2/2001 0158:30 40 sec 1140 16.3

4/11/2001 1657:30 10 sec 1100 -8.0

4/11/2001 1659:35 1 sec 1100 -7.7

4/11/2001 1700:05 10 sec 1100 -7.6

4/11/2001 1700:50 40 sec 1100 -7.5

4/11/2001 1704:30 10 sec 1100 -7.0

4/22/2001 1222:20 30 sec 1010 13.9

5/8/2001 1520:20 3 sec 0910 28.5

5/10/2001 0527:10 20 sec 0930 18.7

5/10/2001 0617:45 10 sec 0930 24.4

5/10/2001 0618:40 20 sec 0930 24.4

3/31/2002 1558:20 5 sec 1110 1.5

3/31/2002 1606:00 10 sec 1110 2.1

3/31/2002 1608:00 4 sec 1110 2.3

3/31/2002 1925:20 50 sec 1120 13.9

3/31/2002 1927:20 3 sec 1120 13.9

3/31/2002 1929:30 10 sec 1120 14.0

5/14/2002 0600:30 10 sec 0820 -3.4

5/14/2002 0601:20 15 sec 0820 -3.4

5/14/2002 0609:50 10 sec 0930 -2.4

5/14/2002 0610:10 15 sec 0930 -2.4

5/14/2002 0633:20 5 sec 0940 0.3

5/14/2002 0636:00 20 sec 0820 0.6

5/14/2002 0649:35 3 sec 0820 2.2

5/14/2002 0653:15 1 sec 0820 2.6

5/14/2002 0654:07 1 sec 0820 2.7

5/14/2002 0654:50 1 sec 0820 2.8

5/14/2002 0655:50 10 sec 0820 2.9
> **DA 00- 2225**
>
> **September 28, 2000**

**OET Extends Effective Date of Antenna Connector Requirement
Indefinitely**

On May 22, 2000, the Office of Engineering and Technology, OET, issued a
Public Notice, DA 00-1087, clarifying 47 CFR 15.203. This rule requires
transmitters authorized under Part 15 to be designed in such a way as to
ensure that no antenna, other than that furnished by the responsible
party, can be used with the device. Typically, a manufacturer will
either design a unique antenna connector or modify a commonly available
connector to satisfy this requirement. In the Public Notice, we noted
several antenna connectors, that were once considered unique, have since
become common place and no longer satisfy the requirement of this rule
section. Hence, effective 30 days after the date of the Public Notice,
these antenna connectors would no longer be acceptable for satisfying
the requirement in Section 15.203.

On June 22, 2000 we extended the effective date of the antenna connector
requirement in the Public Notice to October 1, 2000. However, a Petition
for Reconsideration has been filed and, in order to consider the merits
of the Petition, we are extending the effective date of the Public
Notice indefinitely. After a decision on the merits of the Petition has
been made, we will address the need for a new effective date regarding
DA 00-1087.

Thus, we are extending the effective date of Public Notice, DA 00-1087,
indefinitely.

For further information concerning this Public Notice, contact Joe
Dichoso at the FCC Laboratory, 7435 Oakland Mills Road, Columbia, Md.
21046, (301) 362-3024, or e-mail: jdichoso@fcc.gov.
Spett.le

STUDIO LEGALE TRIBUTARIO

##### E&Y US DESK - Milan

##### FAX 02-89010199

**(e-mail EY US DESK - MILAN:** <EY-USTax.Milan@it.ey.com>***)***

# SCHEDA DI PARTECIPAZIONE

**REGISTRATION FORM**

Con la presente Vi comunichiamo che parteciperemo al CONVEGNO/ This is
to confirm you our attendance to the Seminar entitled

###### 

**"Novità Fiscali per Multinazionali Italiane con attività negli USA e
Multinazionali USA con subsidiaries in Italia alla luce della**

**Nuova Riforma Fiscale Americana"**

"U.S. Tax Update and Developments for Italian and U.S. Multinationals
Under the Recently Enacted

New Tax Legislation"

che si terrà il **18 Novembre 2004 -- ore 14.00-18.15 presso HOTEL
BERNINI BRISTOL - P.zza Barberini 23, Roma (Italia)/**to be held on
**Novembre 18, 2004 -- time 14.00-18.15 HOTEL BERNINI BRISTOL - P.zza
Barberini 23, Rome (Italy)**

Società /Company
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_

Indirizzo/Address
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_

Telefono/Phone
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_

Telefax/Fax
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_

E-mail:
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_

Partecipante (i) /Attendee (s)
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_

Funzione/Title \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_

Data/Date \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_

**INFORMATIVA SUL TRATTAMENTO DEI DATI PERSONALI (Art. 13 D.lgs.
196/03)(Personal data treatment)**

La informiamo che la compilazione del modulo allegato è necessaria per
la partecipazione al convegno. I dati forniti saranno trattati dallo
Studio Legale Tributario, con sede in Via Cornaggia 10, Milano (titolare
del trattamento), con strumenti anche informatici, per le esigenze
connesse all\'organizzazione del convegno, nonchè per l\'invio di inviti
ad eventuali futuri convegni o altri eventi organizzati dallo Studio
Legale Tributario. Esclusivamente per tali scopi i dati potranno,
inoltre, venire a conoscenza del personale dello Studio incaricato della
gestione del convegno e/o di futuri convegni, nonché di Global Shared
Services S.r.l., Via Cornaggia 10, 20123 Milano, nell'ambito di
fornitura di servizi informatici e di archiviazione dati. In qualsiasi
momento potrete verificare i dati che Vi riguardano ed eventualmente
farli correggere, aggiornare o cancellare, o esercitare gli altri
diritti riconosciuti per legge, scrivendo o contattando il titolare
all\'indirizzo sopra indicato (art. 7 D.lgs. 196/03).
TAX RATE

The rate would be the same for all income groups. Rate fixed according
to economic and government conditions. Combined with the deduction, it
would be progressive. All income would be treated equally.

DEDUCTIONS

A\) Maximum deduction would be equal to 3000 hours of the hourly minimum
wage.

> If the minimum wage is \$5.15/hour, the maximum deduction would equal
> \$15,450.00 (\$5.15 X 3000 = \$15,450.) The deduction would be per
> adult's total income.

B)  The \$15,450.00 deduction would include "spending" for mortgages,
    charities, food, clothing, medical care, transportation, education,
    child care, and savings for homes, education, medical care, and
    retirement. A taxpayer would simply report the total of the
    deductions for the year without a specific allocation. Proof of the
    "spending" on the allowed deduction items would have to be presented
    to the I.R.S. upon demand.

\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--

EXAMPLES: 20% RATE + DEDUCTION

1\. 2. 3.

> INCOME: \$15,000 \$50,000 \$200,000

DEDUCTION: \*15,450 \$15,450 \$15,450

TAXABLE INCOME: \$00,000 \$34,550 \$184,550

TAX RATE: .2 .2 .2

TAX: \$00,000 \$ 6,910 \$ 36,910

TAX/\$100 OF INCOME: \$0 \$13.82 \$18.46

\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--

\*Assumes savings were used in order to have a deduction \$15,450. If
only \$15,000.00 was available the deduction be \$15,000.00 or less.
![](media/image1.pct){width="1.8763888888888889in"
height="0.7722222222222223in"}

***Los Alamos National Laboratory and EnTech Strategies, Inc.***

***Santa Fe, New Mexico USA***

***July 17 -- 30, 2005***

***Directions from Albuquerque International Airport to***

***the College of Santa Fe***

From Albuquerque International Airport, take Yale and turn left on
Gibson. Stay on right lane and take the I-25 North Exit to Santa Fe. The
drive from Albuquerque to Santa Fe is approximately one hour.

Once you arrive in Santa Fe, you have two options.

1.  You can take the Cerrillos Road exit off of I-25. Stay on Cerrillos
    Road until you come to St. Michael's Drive/Osage, turn right onto
    St. Michael's Drive. Almost immediately you will see the signage for
    the College of Santa Fe, you will be making another right hand turn
    into the college.

**OR\
**

2.  You can take the St. Francis Drive Exit (US 285; exit #282). Stay on
    St. Francis Drive (you will be traveling north) until you reach the
    St. Michael's Drive exit. Turn right onto the exit ramp, then left
    onto St. Michael's Drive. Stay on St. Michael's Drive until you see
    the signage for the College of Santa Fe on your left.
> Task Order:
>
> Firm shall issue a paper check made payable to Duke University in the
> amount of \$2,604.75. Funds are in support of the Clinical Research
> Program. Funding will support subsistence expenses for a student who
> will be sponsored for this program.
>
> Included with check should be a cover letter noting name of student
> and ID. This information will be provided at the time of award.
>
> Check should be delivered no later than 12/31/06.
>
> \[Preparer: Fran Wagstaff, NIH/NIEHS, 919-541-4182\]
FOR IMMEDIATE RELEASE

CONTACT: Stacey Felzenberg (202) 225-2815

July 17, 2002

**CANTOR: FUNDING TO ARAFAT'S**

**MURDEROUS REGIME MUST END NOW**

***"Taxpayer dollars can no longer be sent to murder innocent
civilians"***

WASHINGTON, DC - Congressman Eric Cantor today expressed his outrage and
disgust at today's bombing at a café in Tel Aviv.

> *"**I condemn this cowardly and murderous attack on innocent
> civilians**,"* Congressman Cantor said. "***These acts of terror
> demonstrate the futility of dealing with Yasser Arafat and his band of
> rogue terrorists.***"

Congressman Cantor authored legislation that would cut off all aid given
directly or indirectly to Yasser Arafat's Palestinian Authority. The
Peace with Security Act, H.R. 3624, has 70 cosponsors in the House of
Representatives and would impose the most severe sanctions against
Arafat of any legislation introduced in the House to date.

> Congressman Cantor concluded, "***Continued funding from the United
> States offers Arafat room to manipulate his finances to further his
> murderous cause. How much longer can we sit by and allow American
> taxpayer money to fund the murder of innocent civilians. The Peace
> with Security Act is the only way to send the message to Arafat that
> America will not tolerate terrorism."***

Congressman Cantor is a freshman Congressman representing Virginia's
7^th^ district. He is the Chairman of the House Taskforce on Terrorism
and Unconventional Warfare as well as a member of the House
International Relations Committee's Middle East and Southeast Asia
Subcommittee. For more information, contact Congressman Cantor at
202-225-2815.

\# \# \#
[Hydraulic Engineering Circular No. 14]{.underline}

hydraulic design of energy dissipators for culverts and channels

Publication No. FHWA EPD-86-110

September 1983

**[Document Availability:]{.smallcaps}**

To download an electronic copy:
http://www.fhwa.dot.gov/engineering/hydraulics/library_listing.cfm

**[Related NHI Training Course:]{.smallcaps}**

FHWA-NHI-135056, Culvert Design

http://www.nhi.fhwa.dot.gov/category.asp?category_id=7

**[Related FHWA Software:]{.smallcaps}**

HY8 Culvert Analysis, version 6.1

http://www.fhwa.dot.gov/engineering/hydraulics/software.cfm

**[FHWA Technical Contacts:]{.smallcaps}**

**Mr. Joe Krolak Mr. Dan Ghere**

Sr. Hydraulics Engineer, FHWA Headquarters Hydraulics Engineer, FHWA
Resource Center

Phone: (202) 366-4611 Phone: (708) 283-3557

Email: <joseph.krolak@fhwa.dot.gov> Email: <dan.ghere@fhwa.dot.gov>
**Electronic Position Description System (ePDS)**

**ePDS Center Administrators**

Updated: December 2, 2008

  ------------ -------------------- ------------------------------- --------------
  **Center**   **Name**             **E-mail Address**              **Phone
                                                                    Number**

  **GSFC**     Alan Hansen          <Alan.C.Hansen@nasa.gov>        301.286.3827

               Nicole Reed          <Nicole.M.Reed@nasa.gov>        301.286.2001

               Nelson Rodriguez     <Nelson.S.Rodriguez@nasa.gov>   301.286.2883

               LaTonyia Guyton      <LaTonyia.N.Guyton@nasa.gov>    301.286.6153
  ------------ -------------------- ------------------------------- --------------
[INSTRUCTIONS FOR USE OF OREGON CONSTRUCTION SPECIFICATION
(CS-13)]{.underline}

[EVACUATION AND BACKFILL OF TRENCHES FOR CONDUITS]{.underline}

1\. [Applicability]{.underline}

> Construction Specification CS-13 is applicable for the excavation and
> backfill of trenches for pipelines and conduits.

2\. [Material Specifications]{.underline}

> The NRCS material specifications complementary to Oregon State,
> Construction Specification CS-13 are MS-204, Concrete Pipe; MS-205,
> Corrugated Metal Pipe; MS-206, Plastic Pipe;
>
> MS-207, Steel Pipe; MS-208, Corrugated Plastic Tile; MS-209, Fabric
> Filters, MS-210, Aggregate Filters; MS-211, Bedding; and MS-220,
> Corrugated Polyethylene Pipe.

3\. [Items to be Included in the Specifications and on the
Drawings]{.underline}:

a\. Required cross-section locations and grades are to be shown on the
drawings.

b\. Specify conduit or pipeline material which includes dimensions,
grade, strength and/or

class and show on the drawings.

c\. Specify bedding and select backfill requirements and show on the
drawings.

d\. Depth, width, side slopes and cover for the trench should be
specified and shown on the drawings.

e\. Bracing, sheeting or other support installations should be shown on
the drawings, if applicable.

f\. Specify backfill provisions.

> g\. The approximate location and limits of utility right-of-way or
> easements should be shown on the drawings, if applicable.

h\. Specify special requirements for control of erosion, sedimentation
water pollution and

air pollution.

i\. Specify method measurement and payment, if applicable.