Number range CHAPTER November 13, 2023

CURRICULUM VITAE

Paul J. Catalano

Department of Biostatistical Science

Dana-Farber Cancer Institute

44 Binney Street

Mayer Bldg., Room 222

Boston, MA 02115

**EDUCATION:**

1987 B.S. Mathematics University of Lowell

1991 Sc.D. Biostatistics Harvard University

**ACADEMIC APPOINTMENTS:**

2001- Lecturer, Department of Biostatistics, Harvard School of Public
Health and Department of Biostatistical Science, Dana-Farber Cancer
Institute

> 2000- Associate Chair, Department of Biostatistical Science,
> Dana-Farber Cancer Institute
>
> 1999-2001 Associate Professor, Department of Biostatistics, Harvard
> School of Public Health and Department of Biostatistical Science,
> Dana-Farber Cancer Institute
>
> 1993-1999 Assistant Professor, Department of Biostatistics, Harvard
> School of Public Health, and

Department of Biostatistical Science, Dana-Farber Cancer Institute,
Boston, Massachusetts

> 1991-1993 Postdoctoral Research Fellow, Department of Biostatistics,
> Harvard School of Public Health,

and Division of Biostatistics and Epidemiology, Dana-Farber Cancer
Institute,

Boston, Massachusetts

> 1989-1991 Research Assistant, Division of Biostatistics and
> Epidemiology, Dana-Farber Cancer Institute,

Boston, Massachusetts

**AWARDS and HONORS:**

1987 Pi Mu Epsilon

1987 Summa Cum Laude

1987 University of Lowell President\'s Award

1987 University of Lowell Dean\'s Award

1987 University of Lowell Mathematics Award

1987-1988 National Research Service Award - Traineeship

1990 Harvard University Robert Reed Prize in Biostatistical Science

1990 Harvard University Outstanding Teaching Assistant Award

**PROFESSIONAL SOCIETIES:**

1987- American Statistical Association

1987- Biometric Society

1987- Institute of Mathematical Statistics

**MAJOR RESEARCH INTERESTS:**

> 1\. Development and application of statistical methodology to
> environmental problems.
>
> 2\. Research in regression methodology, generalized linear models, and
> methods for multiple outcomes.

**TEACHING EXPERIENCE:**

> 1987 Assisted teaching \"Principles of Biostatistics,\" Harvard School
> of Public Health
>
> 1988 Course Coordinator for \"Principles of Biostatistics,\" Harvard
> School of Public Health
>
> 1989 Assisted teaching \"Regression and Analysis of Variance,\"
> Harvard School of Public Health
>
> 1990 Assisted teaching \"Rates and Proportions,\" Harvard School of
> Public Health
>
> 1990 Assisted teaching \"Principles of Biostatistics,\" Harvard School
> of Public Health

1990-1992 Taught \"Nursing Research Methods II,\" Simmons College,
Boston, MA

> 1994-1997 Taught \"Statistical Methods in Biology,\" Harvard School of
> Public Health
>
> 1996,1998 Co-Taught Design and Analysis of Animal Bioassay, Harvard
> School of Public Health
>
> 1996 Co-Taught Statistical Methods for Animal Bioassay, ENAR Short
> Course
>
> 1998 Taught Principles of Biostatistics, Harvard School of Public
> Health
>
> 1998-1999 Taught Principles of Biostatistics, Harvard School of Public
> Health Summer Session
>
> 2000-2003 Taught Basics of Statistical Inference, Harvard School of
> Public Health

**PUBLICATIONS:**

**Original Reports:**

1.  Ryan LM, Catalano PJ, Kimmel CA, Kimmel GL. Relationship between
    fetal weight and malformation in

developmental toxicity studies. Teratol 1991; 44:215-223.

2.  Catalano PJ, Ryan LM. Bivariate latent variable models for clustered
    discrete and continuous outcomes.

J Am Stat Assoc 1992; 87:651-658.

3.  Furlong ST, Gorti R, Catalano PJ, Rose RM. Lipid content of alveolar
    lining material collected by bronchoalveolar lavage. Am Rev Resp Dis
    1992; 145:383-387.

4.  Catalano PJ, Scharfstein, DO, Ryan LM, Kimmel CA, Kimmel GL. A
    statistical model for fetal death, fetal weight, and malformation in
    developmental toxicity studies. Teratol 1993; 47:281-290.

5.  Rose RM, Catalano PJ, Koziel H, Furlong ST. Abnormal lipid
    composition of bronchoalveolar lavage fluid

obtained from individuals with AIDS related lung disease. Am J Resp Crit
Care Med 1994;149:332-338.

6.  Catalano PJ, Ryan LM, Scharfstein DO. Modeling fetal death and
    malformation in developmental toxicity.

Risk Analysis 1994; 14:611-619.

7.  Catalano PJ, Weller E. Statistical variability: What does it mean in
    risk assessment? Reproductive Toxicology

1994; 8:433-437.

8.  Catalano PJ, Ryan LM, Senchaudhuri P. Developmental toxicity
    modeling for risk assessment. ASA Proceedings of the Environmental
    Statistics Section, 1994.

9.  Harkema JR, Morgan KT, Bermudez EG, Catalano PJ, Griffith WC.
    Effects of chronic ozone exposure on the

nasal mucociliary apparatus in the rat. Research Report Number 65, Part
VII. Health Effects Institute,

Cambridge, MA 1995.

10. Catalano PJ, Rogus J, Ryan LM. Robust composite scores based on
    median polish analysis. Research Report

Number 65, Part IX. Health Effects Institute, Cambridge, MA 1995.

11. Catalano PJ, Chang L-Y, Harkema J, Kaden D, Last J, Mellick P, Parks
    W, Pinkerton K, Radhakrishnamurthy B,

Ryan L, Szarek J. NTP/HEI collaborative ozone project: Integrative
summary report. Research Report

Number 65, Part X. Health Effects Institute, Cambridge, MA 1995.

12. Boorman G, Catalano PJ, Jacobson B, Kaden DA, Naus KM, Ryan LM.
    Consequences of prolonged inhalation

of ozone on F344/N rats: Collaborative studies. Part VI: Background and
study design. Research Report

Number 65, Part VI. Health Effects Institute, Cambridge, MA 1995.

13. Weller EA, Catalano PJ, Williams PL. Implications of developmental
    toxicity study design for quantitative risk

assessment. Risk Analysis 1995; 15:567-574.

14. Szarek JL, Stewart NL, Zhang JZ, Webb JA, Valentovic MA, Catalano P.
    Contractile responses and structure

of small bronchi isolated from rats after 20 months' exposure to ozone.
Fundamental and Applied

Toxicology 1995; 28:199-208.

15. Catalano PJ, Ryan LM, Kaden DA, Mellick P. Statistical design
    aspects of the NTP/HEI collaborative study on the health effects of
    chronic ozone inhalation. Inhalation Toxicology 1996; 8:229-249.

16. Killingsworth CR, Alessandrini F, Krisha Murthy GG, Catalano PJ,
    Paulauskis JD, Godleski JJ. Death from

inhalation of fuel oil ash particles in rats with pre-existing pulmonary
inflammation. Proceedings of the Second

Colloquium on Particulate Air Pollution and Human Health. 1996.

17. Catalano PJ. Bivariate modeling of clustered continuous and ordered
    categorical outcomes. Stat Med 1997;

16:883-900.

18. Harkema JR, Catalano PJ, Hotchkiss JA. Consequences of prolonged
    inhalation of ozone in F344/N rats:

Collaborative Studies. Part XII: Atrophy of Bone in Nasal Turbinates.
Research Report Number 65, Part XII.

Health Effects Institute, Cambridge, MA. 1997.

19. Killingsworth CR, Alessandrini F, Krisha Murthy GG, Catalano PJ,
    Paulauskis JD, Godleski JJ. Inflammation,

Chemokine expression and death in monocrotaline-treated rats following
fuel oil fly ash inhalation. Inhalation

Toxicology 1997; 9:541-565.

20. Baird SJS, Catalano PJ, Ryan LM, Evans JS. Evaluation of effect
    profiles: functional observational battery

outcomes. Fundamental and Applied Toxicology 1997; 40:37-51.

21. Catalano PJ, McDaniel KL, Moser VC. The IPCS Collaborative Study on
    Neurobehavioral Screening Methods: VI. Agreement and reliability of
    the data. Neurotoxicology 1997; 18(4):1057-1064.

22. Nichols CR, Catalano PJ, Loehrer PJ, Crawford ED, Vogelzang N,
    Einhorn LH. Randomized comparison of cisplatin and etoposide and
    either bleomycin or ifosfamide in treatment of advanced disseminated
    germ cell tumors: an Eastern Cooperative Oncology Group, Southwest
    Oncology Group and Cancer and Leukemia Group B Study. J Clin Oncol
    1998; 16(4):1287-1293.

23. Graham RA, Wang S, Catalano PJ, Haller DS. Post-operative
    surveillance of colon cancer: preliminary cost

analysis of physician exam, CEA, chest X-ray and colonoscopy. Ann Surg
1998; 228(1):59-63.

24. Horton NJ, Bebchuk JD, Jones CL, Lipsitz SR, Catalano PJ, Zahner
    GEP, Fitzmaurice GM. Goodness of fit for

GEE: An example with mental health service utilization. Stat Med 1999;
18:213-222.

25. Smith MA, Rubinstein L, Anderson JR, Arthur D, Catalano PJ, Freidlin
    B, Heyn R, Khayat A, Krailo M, Land VJ, Miser J, Shuster J, Vena D.
    Secondary leukemia or myelodysplastic syndrome after treatment with
    epipodophyllotoxins. J Clin Oncol 1999; 17:569-577.

26. Regan MM, Catalano PJ. Likelihood models for clustered binary and
    continuous outcomes: Application to developmental toxicology.
    Biometrics 1999; 55:760-768.

27. Regan MM, Catalano PJ. Bivariate dose-response modeling and risk
    estimation in developmental toxicology. Journal of Agricultural,
    Biological and Environmental Statistics 1999; 4:217-237.

28. Goldsmith C-AW, Hamada K, Ning Y, Gin G, Catalano PJ, Krishna Murthy
    GG, Lawrence J, Kobzik L. The effects of environmental aerosols on
    airway hyperresponsiveness in a murine model of asthma. Inhal
    Toxicol 1999; 11(11):981-998.

29. Clarke RW, Catalano PJ, Koutrakis P, Krishna Murthy GG, Sioutas C,
    Paulauskis J, Coull B, Ferguson S, Godleski JJ. Urban air
    particulate inhalation alters pulmonary function and induces
    pulmonary inflammation in a rodent model of chronic bronchitis.
    Inhal Toxicol 1999; 11:637-656.

30. Bernardo MVP, Lipsitz SR, Harrington DP, Catalano PJ. Sample size
    calculations for failure time random variables in non-randomized
    studies. The Statistician 2000; 49(1): 31-40.

31. Regan MM, Catalano PJ. Regression models for mixed discrete and
    continuous outcomes with clustering. Risk Analysis 2000;
    20(3):363-376.

32. Chang L-T, Koutrakis P, Catalano PJ, Suh HH. Hourly personal
    exposures to fine particles and gaseous pollutants: results from
    Baltimore, MD. J Air & Waste Manage Assoc 2000; 50:1223-1235.

33. Talamonti MS, Catalano PJ, Vaughn DJ, Whittington R, Beauchamp RD,
    Berlin J, Benson III AB. An ECOG Phase I trial of protracted venous
    infusion 5-fluorouracil plus weekly gemcitabine with concurrent
    radiation therapy in patients with locally advanced pancreas cancer:
    a regimen with unexpected early toxicity. J Clin Oncol 2000;
    18:3384-3389.

34. Abt E, Suh H, Catalano P, Koutrakis P. Relative contribution of
    outdoor and indoor particle sources to indoor concentrations.
    Environ Sci Technol 2000; 34:3579-3587.

35. Coull B, Catalano PJ, Godleski J. Semiparametric analyses of
    cross-over data with repeated measures. Journal of Agricultural,
    Biological and Environmental Statistics 2000; 5(4):417-429.

36. Clarke RW, Coull B, Reinisch U, Catalano P, Killingsworth CR,
    Koutrakis P, Kavouras I, Krishna Murthy GG, Lawrence J, Lovett E,
    Wolfson JM, Verrier RL, Godleski JJ. Inhaled concentrated ambient
    particles are associated with hematologic and bronchoalveolar lavage
    changes in canines. Environ Health Perspect 2000; 108:1179-1187.

37. Clarke RW, Catalano P, Coull B, Koutrakis P, Krishna Murthy GG, Rice
    T, Godleski JJ. Age-related responses in rats to concentrated urban
    air particles (CAPs). Inhal Tox 2000; 12:73-84.

38. Godleski JJ, Verrier RL, Koutrakis P, Catalano P, Coull BA, Reinisch
    U, Lovett EG, Lawrence J, Krishna Murthy GG, Wolfson JM, Clarke RW,
    Nearing BD. Mechanisms of morbidity and mortality from Exposure to
    ambient air particulate. Cambridge, MA: Health Effects Institute.
    2000.

39. Watanabe T, Wu Tsung-Teh, Catalano PJ, Ueki T, Satriano R, Haller
    DG, Benson AB, Hamilton SR. Molecular predictors of survival after
    adjuvant chemotherapy for colon cancer. New England Journal of
    Medicine 2001; 344:1196-206.

40. Geys H, Regan MM, Catalano PJ, Molenberghs G. Two latent variable
    risk assessment approaches for mixed continuous and discrete
    outcomes from developmental toxicity data. Journal of Agricultural,
    Biological, and Environmental Statistics 2001; 6(3):340-355.

41. Long CM, Suh HH, Kobzik L, Catalano PJ, Ning YY, Koutrakis P. A
    pilot investigation of the relative toxicity of indoor and outdoor
    fine particles: in vitro effects of endotoxin and other particulate
    properties. Environ Health Perspec 2001; 109: 1019-1026.

42. Brand KP, Catalano PJ, Hammitt JK, Rhomberg L, Evans JS. Limitations
    to empirical extrapolation studies: the case of BMD ratios. Risk
    Analysis 2001; 21(4); 625-640.

43. Sarnat JA, Schwartz J, Catalano PJ, Suh HH. Gaseous pollutants in
    particulate matter epidemiology: confounders or surrogates? Environ
    Health Perspec 2001; 109:1053-1061.

44. Long CM, Suh HH, Catalano P, Koutrakis P. Using time- and
    size-resolved particulate data to quantify penetration and
    deposition behavior. Environmental Science and Technology 2001;
    35(10):2089-2099.

45. Kobzik L, Goldsmith C-A W, Ning YY, Qin G, Morgan B, Imrich A,
    Lawrence J, Krishna Murthy GG, Catalano PJ. Effects of combined
    ozone and air pollution particle exposure in mice. Health Effects
    Institute 2001; 106:1-40.

46. Arango D, Corner GA, Wadler S, Catalano PJ, Augenlicht LH. C-myc/p53
    interaction determines sensitivity of human colon carcinoma cells to
    5-fluorouracil in vitro and in vivo. Cancer Res 2001; 61:4910-4915.

47. Green RJ, Metlay JP, Propert K, Catalano PJ, Macdonald JS, Mayer RJ,
    Haller DG. Surveillance for second primary colorectal cancers after
    adjuvant chemotherapy: an analysis of intergroup --0089. Ann Intern
    Med 2002; 335-337.

48. Hinton S, Catalano P, Einhorn LH, Loehrer PJ, Kuzel T, Vaughn D,
    Wilding G. Phase II study of paclitaxel plus gemcitabine in
    refractory germ cell tumors (E9897): a trial of the Eastern
    Cooperative Oncology Group. J Clin Oncol 2002; 20(7):1859-1863.

49. Malone T, Catalano PJ, O'Dwyer PJ, Giantonio B. High rate of consent
    to bank biologic samples for future research: the Eastern
    Cooperative Oncology Group Experience. JNCI (Brief Communication)
    2002; 94(10):769-771.

50. Goldsmith C, Ning Y, Qin G, Morgan B, Imrich A, Lawrence J, Murthy
    GG, Catalano P, Kobzik L. Effect of combined ozone and air pollution
    particle exposure in mice. Inhal Tox 2002; 14:325-347.

51. Wadler S, Brain C, Catalano P, Einzig AI, Cella D, Benson AB.
    Randomized phase II trial of either Fluorouracil, Parenteral
    Hydroxyurea, interferon-α-2a, and Filgrastim or
    Doxorubicin/Docetaxel in patients with advanced gastric cancer with
    quality-of-life assessment: ECOG study E6296. The Cancer Journal
    2002; 8(3):282-286.

52. Berlin JD, Catalano P, Thomas JP, Kugler JW, Haller DG, Benson II
    AB. Phase III study of gemcitabine in combination with fluorouracil
    versus gemcitabine alone in patients with advanced pancreatic
    carcinoma: Eastern Cooperative Oncology Group Trial E2297. J Clin
    Oncol 2002; 20(15):3270-3275.

53. McCollum AD, Catalano PJ, Haller DG, Mayer RJ, Macdonald JS, Benson
    III AB, Fuchs CS. Outcomes and toxicity in African-American and
    Caucasian patients in a randomized adjuvant chemotherapy trial for
    colon cancer. J Natl Cancer Inst 2002; 94:1160-1167.

54. Marsh JC, Catalano P, Huang J, Graham DL, Cornfeld MJ, O'Dwyer PJ,
    Benson AB. Eastern Cooperative Oncology Group Phase II Trial (E4296)
    of oral 5-Fluorouracil and Eniluracil as a 28-day regimen in
    metastatic colorectal cancer. Clinical Colorectal Cancer 2002;
    2(1):43-50.

55. Meyerhardt JA, Catalano PJ, Haller DG, Mayer RJ, Macdonald JS,
    Benson AB III, Fuchs CS. Impact of diabetes mellitus on outcomes in
    patients with colon cancer. J Clin Oncol 2003; 21:433-440.

56. Johnston PG, Benson III AB, Catalano P, Sambasiva Rao M, O'Dwyer PJ,
    Allegro CJ. Thymidylate synthase protein expression in primary
    colorectal cancer: lack of correlation with outcome and response to
    fluorouracil in metastatic disease sites. J Clin Oncol 2003;
    21(5):815-819.

57. Hinton S, Catalano PJ, Einhorn LH, Nichols CR, Crawford ED,
    Vogelzang N, Trump D, Loehrer PJ. Cisplatin, etoposide and either
    bleomycin or ifosfamide in the treatment of disseminated germ cell
    tumors. Cancer 2003; 97:1869-1875.

58. Joseph NE, Sigurdson ER, Hanlon AL, Wang H, Mayer RJ, MacDonald JS,
    Catalano PJ, Haller DG. Accuracy of determining nodal negativity in
    colorectal cancer on the basis of the number of nodes retrieved on
    resection. Ann Surg Oncol 2003; 10:213-218.

59. Yeap BY, Catalano PJ, Ryan LM, Davidian M. A robust two-stage
    approach to repeated measurements analysis of chronic ozone exposure
    in rats. Journal of Agricultural, Biological and Environmental
    Statistics (in press).

**Books, Monographs and Reviews:**

1.  Catalano PJ, Ryan LM. Statistical methods in developmental
    toxicology. In: Patil GP, Rao CR, eds. Handbook of Statistics, vol.
    12: Environmental Statistics. Amsterdam:Elsevier Publishers, 1994.

2.  Catalano PJ, Ryan LM. Statistical issues in developmental
    toxicology. In: Smith CM, Christiani DC and Kelsy KT, eds. Chemical
    Risk Assessment and Occupational Health: Current Applications,
    Limitations, and Future Prospects. Westport, CT:Greenwood Publishing
    Group, 1994.

3.  Catalano PJ. Neurotoxicity. In: El-Shaarawi A and Piegorsch W, eds.
    Encyclopedia of Environmetrics. To appear. West Sussex: Wiley.

4.  Regan MM, Catalano PJ. Combined continuous and discrete outcomes.
    In: Topics in Modelling of Clustered Data. Boca Raton, FL: CRC Press
    LLC, 2002.