Russian Health Studies Program

Peer Reviewed Publications and Outcomes

December 31, 2007

+----+---------+----------+-----------+------+-----------------------+
| *  | **      | **U.S.   | **Russian | **Nu | # Outcomes            |
| *P | Project | PI**     | PI**      | mber |                       |
| ro | Name**  |          |           | of   |                       |
| je |         |          |           | P    |                       |
| ct |         |          |           | eer- |                       |
| Nu |         |          |           | Revi |                       |
| mb |         |          |           | ewed |                       |
| er |         |          |           | Pu   |                       |
| ** |         |          |           | blic |                       |
|    |         |          |           | atio |                       |
|    |         |          |           | ns** |                       |
+====+=========+==========+===========+======+=======================+
| 1  | Techa   | Lynn     | Marina    | 69   | In addition to        |
| .1 | River   | Anspaugh | Degteva   |      | providing the         |
|    | Pop     |          |           |      | dosimetry data for    |
|    | ulation | ### Un   | *Urals    |      | Project 1.2b, Techa   |
|    | Do      | iversity | Research  |      | River Population      |
|    | simetry |  of Utah | Center    |      | Epidemiology, this    |
|    |         |          | for       |      | project also is       |
|    | 19      |          | Radiation |      | providing valuable,   |
|    | 99-2003 |          | Medicine* |      | new information for   |
|    |         |          |           |      | improving dose        |
|    | 20      |          |           |      | estimation from the   |
|    | 04-2006 |          |           |      | intake of ^90^Sr.     |
|    |         |          |           |      | Current work is       |
|    | 20      |          |           |      | directed to           |
|    | 07-2009 |          |           |      | completion of the     |
|    |         |          |           |      | Techa River Dosimetry |
|    |         |          |           |      | System-2009.          |
+----+---------+----------+-----------+------+-----------------------+
| 1. | Data    | Donna    | Nikolai   | 1    | This completed        |
| 2a | Prese   | Cragle   | Startsev  |      | project established a |
|    | rvation |          |           |      | document imaging      |
|    | at      | *Oak     | *Urals    |      | system at URCRM for   |
|    | URCRM   | Ridge    | Research  |      | preserving valuable   |
|    |         | I        | Center    |      | medical records of    |
|    | 19      | nstitute | for       |      | residents of the      |
|    | 97-2005 | for      | Radiation |      | Southern Urals region |
|    |         | Science  | Medicine* |      | exposed to radiation  |
|    |         | and      |           |      | due to the operations |
|    |         | Ed       |           |      | of the Mayak facility |
|    |         | ucation* |           |      | and environmental     |
|    |         |          |           |      | releases. These       |
|    |         |          |           |      | documents contain     |
|    |         |          |           |      | information from 1951 |
|    |         |          |           |      | to the present with   |
|    |         |          |           |      | details of medical    |
|    |         |          |           |      | examinations,         |
|    |         |          |           |      | individual dose       |
|    |         |          |           |      | measurements,         |
|    |         |          |           |      | addresses, causes of  |
|    |         |          |           |      | death, and other data |
|    |         |          |           |      | necessary for         |
|    |         |          |           |      | epidemiologic studies |
|    |         |          |           |      | and dose              |
|    |         |          |           |      | reconstruction.       |
|    |         |          |           |      | Computer scanning     |
|    |         |          |           |      | equipment was         |
|    |         |          |           |      | purchased, installed, |
|    |         |          |           |      | and later updated.    |
|    |         |          |           |      | Scanning,             |
|    |         |          |           |      | verification,         |
|    |         |          |           |      | indexing, and         |
|    |         |          |           |      | creation of a         |
|    |         |          |           |      | computer database of  |
|    |         |          |           |      | the scanned documents |
|    |         |          |           |      | were completed.       |
+----+---------+----------+-----------+------+-----------------------+
| 1. | Techa   | Faith    | Alexander | 22   | The combined work of  |
| 2b | River   | Davis    | Akleyev   |      | Projects 1.1 and 1.2b |
|    | Pop     |          |           |      | addresses the         |
|    | ulation | *Un      | *Urals    |      | important question of |
|    | Mo      | iversity | Research  |      | the validity of the   |
|    | rbidity | of       | Center    |      | dose-response model   |
|    |         | Illinois | for       |      | (linear,              |
|    | 19      | at       | Radiation |      | non-threshold) used   |
|    | 97-2003 | Chicago* | Medicine* |      | by national and       |
|    |         |          |           |      | international         |
|    | 20      |          |           |      | authorities in the    |
|    | 04-2006 |          |           |      | development of        |
|    |         |          |           |      | radiation-protection  |
|    | 20      |          |           |      | standards,            |
|    | 07-2009 |          |           |      | particularly as       |
|    |         |          |           |      | applied radiation     |
|    |         |          |           |      | delivered at low dose |
|    |         |          |           |      | rates. The Extended   |
|    |         |          |           |      | Techa River Cohort    |
|    |         |          |           |      | (ETRC) reflects a     |
|    |         |          |           |      | general population    |
|    |         |          |           |      | exposed to moderate   |
|    |         |          |           |      | doses of radiation at |
|    |         |          |           |      | low dose rates 50     |
|    |         |          |           |      | years ago. The        |
|    |         |          |           |      | population is         |
|    |         |          |           |      | relatively large      |
|    |         |          |           |      | (\~30,000) and has    |
|    |         |          |           |      | been actively         |
|    |         |          |           |      | followed so that      |
|    |         |          |           |      | results can be        |
|    |         |          |           |      | expected within a     |
|    |         |          |           |      | reasonable time       |
|    |         |          |           |      | frame. Preliminary    |
|    |         |          |           |      | results indicate an   |
|    |         |          |           |      | excess in leukemia    |
|    |         |          |           |      | and other cancers in  |
|    |         |          |           |      | this population.      |
|    |         |          |           |      | Preliminary risk      |
|    |         |          |           |      | assessment indicates  |
|    |         |          |           |      | a statistically       |
|    |         |          |           |      | significant dose      |
|    |         |          |           |      | dependence of         |
|    |         |          |           |      | incidence rates, but  |
|    |         |          |           |      | confounding sources   |
|    |         |          |           |      | of exposure and       |
|    |         |          |           |      | potential biases in   |
|    |         |          |           |      | the collection of the |
|    |         |          |           |      | outcome data in this  |
|    |         |          |           |      | population must be    |
|    |         |          |           |      | investigated and      |
|    |         |          |           |      | resolved.             |
+----+---------+----------+-----------+------+-----------------------+
| 1  | Reconst | Lynn     | Yuri      | 2    | This project is       |
| .4 | ruction | Anspaugh | Mokrov    |      | concerned with the    |
|    | of Dose |          |           |      | reconstruction of     |
|    | to the  | ### Un   | *Mayak    |      | doses to the          |
|    | Re      | iversity | P         |      | residents of Ozersk   |
|    | sidents |  of Utah | roduction |      | from the airborne     |
|    | of      |          | Ass       |      | radionuclide          |
|    | Ozersk  |          | ociation* |      | emissions from Mayak. |
|    | from    |          |           |      | Focus is on the       |
|    | Mayak   |          |           |      | emission of ^131^I    |
|    | Ope     |          |           |      | and dose to the       |
|    | rations |          |           |      | thyroid glands of     |
|    |         |          |           |      | children. Data will   |
|    | 20      |          |           |      | support an            |
|    | 03-2004 |          |           |      | epidemiologic study   |
|    |         |          |           |      | of thyroid cancer in  |
|    | 20      |          |           |      | children sponsored by |
|    | 05-2009 |          |           |      | the National Cancer   |
|    |         |          |           |      | Institute. This       |
|    |         |          |           |      | should help resolve   |
|    |         |          |           |      | the dichotomy between |
|    |         |          |           |      | the studies at        |
|    |         |          |           |      | Hanford (no observed  |
|    |         |          |           |      | effect) and Chernobyl |
|    |         |          |           |      | (large effect). The   |
|    |         |          |           |      | data also will        |
|    |         |          |           |      | determine whether     |
|    |         |          |           |      | these emissions are a |
|    |         |          |           |      | confounding factor in |
|    |         |          |           |      | the study of the      |
|    |         |          |           |      | Extended Techa River  |
|    |         |          |           |      | Cohort (Projects 1.1  |
|    |         |          |           |      | and 1.2b).            |
+----+---------+----------+-----------+------+-----------------------+
| 2  | Mayak   | Ethel    | Nina      | 6    | This project is the   |
| .2 | Worker  | Gilbert  | Kos       |      | first to demonstrate  |
|    | Mo      |          | hurnikova |      | statistically         |
|    | rtality | *        |           |      | significant           |
|    |         | National | *Southern |      | associations between  |
|    | 19      | Cancer   | Urals     |      | occupational exposure |
|    | 97-2002 | In       | B         |      | to plutonium (Pu) and |
|    |         | stitute* | iophysics |      | lung, liver, and bone |
|    | 20      |          | I         |      | cancer.               |
|    | 03-2005 |          | nstitute* |      |  Dose-response        |
|    |         |          |           |      | analyses have been    |
|    | 20      |          |           |      | conducted for lung    |
|    | 06-2008 |          |           |      | cancer and express    |
|    |         |          |           |      | both the excess       |
|    |         |          |           |      | relative risk and     |
|    |         |          |           |      | excess absolute risk  |
|    |         |          |           |      | as a function of      |
|    |         |          |           |      | plutonium dose,       |
|    |         |          |           |      | external dose,        |
|    |         |          |           |      | gender, and attained  |
|    |         |          |           |      | age.  Similar         |
|    |         |          |           |      | analyses are underway |
|    |         |          |           |      | for liver and bone    |
|    |         |          |           |      | cancers. Using the    |
|    |         |          |           |      | Mayak Worker Doses    |
|    |         |          |           |      | 2005 database,        |
|    |         |          |           |      | researchers will be   |
|    |         |          |           |      | computing new cancer  |
|    |         |          |           |      | risk estimates for    |
|    |         |          |           |      | both internal and     |
|    |         |          |           |      | external ionizing     |
|    |         |          |           |      | radiation exposures.  |
+----+---------+----------+-----------+------+-----------------------+
| 2  | Mayak   | Scott    | Victor    | 46   | In addition to        |
| .4 | Worker  | Miller   | Kh        |      | providing the         |
|    | Do      |          | okhryakov |      | dosimetric data for   |
|    | simetry | ### Un   |           |      | Project 2.2, Mayak    |
|    |         | iversity | *Southern |      | Worker Mortality,     |
|    | 20      |  of Utah | Urals     |      | this project has      |
|    | 01-2003 |          | B         |      | enhanced the          |
|    |         |          | iophysics |      | understanding of Pu   |
|    | 20      |          | In        |      | metabolism in the     |
|    | 04-2006 |          | stitute*; |      | human body and        |
|    |         |          |           |      | improved the          |
|    | 20      |          | Evgeny    |      | biokinetic models for |
|    | 07-2008 |          | Vasilenko |      | assessing dose from   |
|    |         |          |           |      | Pu uptakes. These     |
|    |         |          | *Mayak    |      | outcomes will be of   |
|    |         |          | P         |      | direct benefit to DOE |
|    |         |          | roduction |      | in improving the      |
|    |         |          | Ass       |      | determination of dose |
|    |         |          | ociation* |      | to DOE workers from   |
|    |         |          |           |      | Pu exposure.          |
|    |         |          |           |      | Researchers prepared  |
|    |         |          |           |      | the Doses 2005        |
|    |         |          |           |      | database for 18,831   |
|    |         |          |           |      | Mayak workers         |
|    |         |          |           |      | employed between 1948 |
|    |         |          |           |      | and 1972 and are now  |
|    |         |          |           |      | preparing the Doses   |
|    |         |          |           |      | 2008 database for     |
|    |         |          |           |      | about 27,000 workers  |
|    |         |          |           |      | hired between 1948    |
|    |         |          |           |      | and 1982.             |
+----+---------+----------+-----------+------+-----------------------+
| 2  | I       | Raymond  | Sergey    | 8    | The earlier efforts   |
| .5 | mproved | G        | Romanov   |      | in this project       |
|    | Pl      | uilmette |           |      | focused on            |
|    | utonium |          | *Southern |      | determining the       |
|    | Dose    | *Los     | Urals     |      | amount and location   |
|    | Ass     | Alamos   | B         |      | of long-term-retained |
|    | essment | National | iophysics |      | Pu in the lungs of    |
|    | Methods | Lab      | I         |      | Mayak workers. This   |
|    | for     | oratory* | nstitute* |      | study was the first   |
|    | Mayak   |          |           |      | to demonstrate very   |
|    | Workers |          |           |      | long-term             |
|    |         |          |           |      | sequestration of Pu   |
|    | 19      |          |           |      | particles in human    |
|    | 99-2003 |          |           |      | lung parenchyma.      |
|    |         |          |           |      | Then, this knowledge  |
|    | 20      |          |           |      | of Pu distribution in |
|    | 04-2006 |          |           |      | lung was used with    |
|    |         |          |           |      | state of the art dose |
|    | 20      |          |           |      | assessment methods to |
|    | 08-2010 |          |           |      | modify the human      |
|    |         |          |           |      | respiratory tract     |
|    |         |          |           |      | dosimetry models to   |
|    |         |          |           |      | improve dose          |
|    |         |          |           |      | assessment. The main  |
|    |         |          |           |      | objective of the      |
|    |         |          |           |      | current phase is to   |
|    |         |          |           |      | obtain new knowledge  |
|    |         |          |           |      | and to implement      |
|    |         |          |           |      | additional useful     |
|    |         |          |           |      | tools that will       |
|    |         |          |           |      | facilitate the        |
|    |         |          |           |      | development of a new  |
|    |         |          |           |      | harmonized Pu         |
|    |         |          |           |      | dosimetry system,     |
|    |         |          |           |      | which will eventually |
|    |         |          |           |      | replace the Mayak     |
|    |         |          |           |      | Doses 2005 dosimetry  |
|    |         |          |           |      | system in Project     |
|    |         |          |           |      | 2.4, Mayak Worker     |
|    |         |          |           |      | Dosimetry. This       |
|    |         |          |           |      | includes addressing   |
|    |         |          |           |      | several critical      |
|    |         |          |           |      | issues for lung       |
|    |         |          |           |      | dosimetry modeling,   |
|    |         |          |           |      | combining Pu dose     |
|    |         |          |           |      | estimates with the    |
|    |         |          |           |      | uncertainties for     |
|    |         |          |           |      | individual Mayak      |
|    |         |          |           |      | workers by using      |
|    |         |          |           |      | available urine       |
|    |         |          |           |      | bioassay and/or       |
|    |         |          |           |      | postmortem tissue     |
|    |         |          |           |      | data together with    |
|    |         |          |           |      | the Bayesian approach |
|    |         |          |           |      | for individual dose   |
|    |         |          |           |      | assessment, and       |
|    |         |          |           |      | applying the          |
|    |         |          |           |      | probability           |
|    |         |          |           |      | distributions for     |
|    |         |          |           |      | intake and biokinetic |
|    |         |          |           |      | model parameters for  |
|    |         |          |           |      | assessing the dose    |
|    |         |          |           |      | for workers monitored |
|    |         |          |           |      | for Pu to Mayak       |
|    |         |          |           |      | workers for whom      |
|    |         |          |           |      | little or no Pu       |
|    |         |          |           |      | monitoring data are   |
|    |         |          |           |      | available.            |
+----+---------+----------+-----------+------+-----------------------+
| 2  | Mo      | Steve    | Vitaly    | 4    | The original project  |
| .6 | lecular | Belinsky | Telnov    |      | demonstrated that the |
|    | Markers |          |           |      | p16 tumor suppressor  |
|    | of Lung | *        | *Southern |      | gene was targeted for |
|    | Cancer  | Lovelace | Urals     |      | inactivation by       |
|    | in      | Res      | B         |      | promoter              |
|    | Mayak   | piratory | iophysics |      | hypermethylation in   |
|    | Workers | Research | I         |      | plutonium-induced     |
|    |         | In       | nstitute* |      | adenocarcinomas of    |
|    | 20      | stitute* |           |      | the lung. The current |
|    | 00-2002 |          |           |      | phase of the research |
|    |         |          |           |      | is to examine         |
|    | 20      |          |           |      | methylation profiles  |
|    | 03-2008 |          |           |      | in adenocarcinomas    |
|    |         |          |           |      | and squamous cell     |
|    |         |          |           |      | carcinomas of the     |
|    |         |          |           |      | lung in Mayak workers |
|    |         |          |           |      | and controls.         |
+----+---------+----------+-----------+------+-----------------------+
| 2  | Ra      | David    | Tamara    | 5    | The feasibility study |
| .7 | diation | Brenner  | Azizova   |      | indicated a           |
|    | Bio     |          |           |      | statistically         |
|    | markers | ### Col  | *Southern |      | significant           |
|    |         | umbia Un | Urals     |      | dose-response between |
|    | 20      | iversity | B         |      | Pu exposure and       |
|    | 01-2002 |          | iophysics |      | intra-arm chromosomal |
|    |         |          | I         |      | aberrations from      |
|    | 20      |          | nstitute* |      | worker blood samples. |
|    | 03-2008 |          |           |      | This study may lead   |
|    |         |          |           |      | to the development of |
|    |         |          |           |      | a dose-related        |
|    |         |          |           |      | biomarker of Pu       |
|    |         |          |           |      | exposure.             |
+----+---------+----------+-----------+------+-----------------------+
| 2  | Mayak   | Chr      | Klara     | 8    | The Mayak Worker      |
| .8 | Worker  | istopher | Muksinova |      | Tissue Repository now |
|    | Tissue  | Loffredo |           |      | holds tissues from    |
|    | Rep     |          | *Southern |      | 1,000 deceased        |
|    | ository | #        | Urals     |      | workers,              |
|    |         | ## Georg | B         |      | surgical/biopsy       |
|    | 19      | etown Un | iophysics |      | tissue samples from   |
|    | 98-2002 | iversity | I         |      | 500 donors, and blood |
|    |         |          | nstitute* |      | DNA, cells, serum     |
|    | 20      |          |           |      | samples from 4,800    |
|    | 03-2007 |          |           |      | professionals and     |
|    |         |          |           |      | residents of Ozersk.  |
|    | 20      |          |           |      | In conjunction with   |
|    | 08-2012 |          |           |      | medical,              |
|    |         |          |           |      | occupational, and     |
|    |         |          |           |      | dosimetry             |
|    |         |          |           |      | information, data     |
|    |         |          |           |      | collected in the      |
|    |         |          |           |      | repository will make  |
|    |         |          |           |      | possible the conduct  |
|    |         |          |           |      | of molecular          |
|    |         |          |           |      | epidemiology studies. |
|    |         |          |           |      | Such studies combine  |
|    |         |          |           |      | epidemiologic with    |
|    |         |          |           |      | genetic/molecular     |
|    |         |          |           |      | methods to establish  |
|    |         |          |           |      | an association        |
|    |         |          |           |      | between disease and   |
|    |         |          |           |      | radiation exposure in |
|    |         |          |           |      | individuals.          |
+----+---------+----------+-----------+------+-----------------------+
| 2  | D       | Dale     | Sergey    | 0    | This project is meant |
| .9 | atabase | Preston  | Romanov   |      | to combine databases  |
|    | Inte    |          |           |      | located in two        |
|    | gration | *        | *Southern |      | Russian organizations |
|    |         | Hirosoft | Urals     |      | so as to facilitate   |
|    | 20      | Intern   | B         |      | researcher access to  |
|    | 01-2005 | ational* | iophysics |      | data. As such, it is  |
|    |         |          | In        |      | not intended to       |
|    |         | Eric     | stitute*; |      | result in             |
|    |         | Grant    |           |      | publications or       |
|    |         |          | Evgeny    |      | influence radiation   |
|    |         | *R       | Vasilenko |      | protection standards. |
|    |         | adiation |           |      |                       |
|    |         | Effects  | *Mayak    |      |                       |
|    |         | Research | P         |      |                       |
|    |         | Fou      | roduction |      |                       |
|    |         | ndation* | Ass       |      |                       |
|    |         |          | ociation* |      |                       |
+----+---------+----------+-----------+------+-----------------------+

As of December 31, 2007, U.S. and Russian investigators working on
projects funded by the Russian Health Studies Program have generated 171
peer-reviewed publications.

Russian Health Studies Program

171 Peer Reviewed Publications

December 31, 2007

**Project 1.1: Techa River Population Dosimetry (69)**

1.  Anspaugh, L.R.; Degteva, M.O.; Vasilenko, E.K. Mayak Production
    Association: Introduction. *Radiat. Environ. Biophys.* 41:19--22;
    2002.

2.  Anspaugh, L.R.; Shishkina, E.A.; Shved, V.A.; Degteva, M.O.;
    Tolstykh, E.I.; Napier, B.A. Comment on paper by Hayes, Haskell, and
    Kenner. *Health Phys.* 85:622--624; 2003.

3.  Anspaugh, L.R.; Degteva, M.O.; Vorobiova, M.I.; Mokrov, Y. G;
    Napier, B.A. Dosimetry for members of the Extended Techa River
    Cohort. *Health Phys.* 91:393-394; 2006.

4.  Bauchinger, M.; Salassidis, K.; Braselmann, H.; Vozilova, A.;
    Pressl, S.; Stephan, G.; Snigiryova, G.; Kozheurov, V.P.;
    Akleyev, A. FISH-based analysis of stable translocations in a Techa
    River population. *Intl. J. Radiat. Biol.* 73:605--612; 1998.

5.  Bougrov, N.G.; Göksu, H.Y.; Haskell, E.; Degteva, M.O.; Meckbach,
    R.; Jacob, P. Issues in the reconstruction of environmental doses on
    the basis of thermoluminescence measurements in the Techa Riverside.
    *Health Phys.* 75:574--583; 1998.

6.  Bougrov, N.G.; Degteva, M.O.; Göksu, H.Y.; Meckbach, R.; Jacob, P.
    Retrospective thermoluminescence dosimetry in the riverside
    territories of the upper-Techa River. *Radiat Safety Problems*
    (Mayak Production Association Scientific Journal) № 3:5162; 2001 (in
    Russian).

7.  Bougrov, N.G.; Baturin, V.A.; Göksu, H.Y.; Degteva, M.O.; Jacob, P.
    Investigation of thermoluminescence dosimetry in the Techa River
    flood plain: Analysis of the new results. *Radiat. Prot. Dosim.*
    101:225--228; 2002.

8.  Degteva, M.O.; Kozheurov, V.P.; Burmistrov, D.S.; Vorobiova, M.I.;
    Valchuk, V.V.; Bougrov, N.G.; Shishkina, H.A. An approach to dose
    reconstruction for the Urals population. *Health Phys.* 71:71--76;
    1996.

9.  Degteva, M.O.; Kozheurov, V.P.; Tolstykh, E.I. Retrospective
    dosimetry related to chronic environmental exposure. *Radiat. Prot.
    Dosim.* 79:155--160; 1998.

10. Degteva, M.O.; Vorobiova, M.I.; Kozheurov, V.P.; Tolstykh, E.I.;
    Anspaugh, L.R.; Napier, B.A. Dose reconstruction system for the
    exposed population living along the Techa River. *Health Phys.*
    78:542--554; 2000.

11. Degteva, M.O.; Kozheurov, V.P.; Tolstykh, E.I.; Vorobiova, M.I.;
    Anspaugh, L.R.; Napier, B.A.; Kovtun, A.N. The Techa River Dosimetry
    System: Methods for the reconstruction of internal dose. *Health
    Phys.* 79:24--35; 2000.

12. Degteva, M.O.; Vorobiova, M.I.; Tolstykh, E.I.; Shagina, N.B.;
    Anspaugh, L.R.; Napier, B.A. Dosimetry of the Techa River System:
    Dose reconstruction for radiation consequences risk assessment.
    *Radiat. Safety Problems* (Mayak Production Association Scientific
    Journal) № 4:3646; 2000 (in Russian).

13. Degteva, M.O.; Tolstykh, E.I.; Vorobiova, M.I.; Shagina, N.B.;
    Kozheurov, V.P.; Anspaugh, L.R.; Napier, B.A. Improving the dose
    reconstruction system for estimating the risk of late effects in the
    Techa River population. *Med. Radiol. Radiat. Saf.* 46:9--21; 2001
    (in Russian).

14. Degteva, M.O.; Shagina, N.B.; Tolstykh, E.I.; Vorobiova, M.I.;
    Napier, B.A.; Anspaugh, L.R. Studies on the Techa River populations:
    Dosimetry. *Radiat. Environ. Biophys.* 41:41--44; 2002.

15. Degteva, M.O.; Tolstykh, E.I.; Vorobiova, M.I. Assessment of doses
    to the offspring of the Techa River Cohort due to intakes of
    radionuclides by the mother. *Radiat. Prot. Dosim.* 105:609--614;
    2003.

16. Degteva, M.O.; Anspaugh, L.R.; Akleyev, A.V.; Jacob, P.; Ivanov,
    D.V.; Wieser, A.; Vorobiova, M.I.; Shishkina, E.A.; Shved, V.A.;
    Vozilova, A.; Bayankin, S.N.; Napier, B.A. Electron paramagnetic
    resonance and fluorescence in situ hybridization-based
    investigations of individual doses for persons living at Metlino in
    the upper reaches of the Techa River. *Health Phys.* 88:139--153;
    2005.

17. Degteva, M.O.; Tolstykh, E.I.; Vorobiova, M.I.; Shagina, N.B.;
    Shishkina, E.A.; Bougrov, N.G.; Anspaugh, L.R.; Napier, B.A. Techa
    River Dosimetry System: Current status and future. *Radiat. Safety
    Problems* (Mayak Production Association Scientific Journal) 1:8195;
    2006 (in Russian).

18. Degteva, M.O.; Vorobiova, M.I.; Tolstykh, E.I.; Shagina, N.B.,
    Shishkina, E.A.; Anspaugh, L.R.; Napier, B.A.; Bougrov, N.G.; Shved,
    V.A.; Tokareva, E.E. Development of an improved dose reconstruction
    system for the Techa River population affected by the operation of
    the Mayak Production Association. *Radiat. Res.* 166:255--270; 2006.

19. Degteva, M.O.; Shagina, N.B.; Tolstykh, E.I.; Bougrov, N.G.;
    Zalyapin, V.I.; Anspaugh, L.R.; Napier, B.A. An approach to
    reduction of uncertainties in internal doses reconstructed for the
    Techa River population. *Radiat. Prot. Dosim.* 2007:1--6
    doi:10.1093/rpd/ncm410.

20. Göksu, H.Y.; Heide, L.M.; Bougrov, N.G.; Dalheimer, A.R.; Meckbach,
    R.; Jacob, P. Depth-dose distribution in bricks determined by
    thermoluminescence and by Monte-Carlo calculation for external -dose
    reconstruction. *Appl. Radiat. Isot.* 47:433--440; 1996.

21. Göksu, H.Y.; Degteva, M.O.; Bougrov, N.G.; Meckbach, R.; Haskell,
    E.H.; Bailiff, I.K.; Bøtter-Jensen, L.; Jungner, H.; Jacob, P. First
    international intercomparison of luminescence techniques using
    samples from the Techa River Valley. *Health Phys.* 82:94--102;
    2002.

22. Göksu, H.Y.; Semiochkina, N.; Shishkina, E.A.; Wieser, A.;
    El-Faramawy, N.A.; Degteva, M.O.; Jacob, P.; Ivanov, D.V. Thin layer
    -Al2O3: C beta dosimeters for the assessment of current dose rate
    in teeth due to 90Sr intake and comparison with electron
    paramagnetic resonance dosimetry. *Radiat. Prot. Dosim.*
    101:507--513; 2002.

23. Haskell, E.H.; Hayes, R.B.; Romanyukha, A.A.; Kenner, G.H.
    Preliminary report on the development of a virtually non-destructive
    additive dose technique for EPR dosimetry. *Appl. Radiat. Isot.*
    52:1065--1070; 2000.

24. Jacob, P.; Göksu, Y.; Taranenko, V.; Meckbach, R.; Bougrov, N.G.;
    Degteva, M.O.; Vorobiova, M.I. On an evaluation of external dose
    values in the Techa River Dosimetry System (TRDS) 2000. *Radiat.
    Environ. Biophys.* 42:169--174; 2003.

25. Khokhryakov, V.V.; Drozhko, E.G.; Glagolenko, Y.V.; Rovny, S.I.;
    Vasilenko, E.K.; Suslov, A.; Anspaugh, L.R.; Napier, B.A; Bouville,
    A.; Khokhryakov, V.F.; Suslova, K.G.; Romanov, S.A. Studies on the
    Ozyorsk population: Dosimetry. *Radiat. Environ. Biophys*.
    41:33--35; 2002.

26. Koshta, A.A.; Wieser, A.; Ignatiev, E.A.; Bayankin, S.; Romanyukha,
    A.; Degteva, M.O. New computer procedure for routine EPR-dosimetry
    on tooth enamel: Description and verification. *Appl. Radiat. Isot.*
    52:1287--1290; 2000.

27. Kovtun, A.N.; Puzikov, A.G.; Sokolov, I.A.; Kozheurov, V.P.;
    Degteva, M.O. Anthropomorphic phantom with strontium-90 incorporated
    in the skeleton. *Radiat. Prot. Dosim.* 89:302--304; 2000.

28. Kozheurov, V.P.; Zalyapin, V.I.; Shagina, N.B.; Tokareva, E.E.;
    Degteva, M.O.; Tolstykh, E.I.; Anspaugh, L.R.; Napier, B.A.
    Evaluation of uncertainties in the 90Sr-body-burdens obtained by
    whole-body count: Application of Bayes' rule to derive detection
    limits by analysis of *a posteriori* data*. Appl. Radiat. Isot.*
    57:525--535; 2002.

29. Napier, B.A.; Shagina, N.B.; Degteva, M.O.; Tolstykh, E.I.;
    Vorobiova, M.I.; Anspaugh, L.R. Preliminary uncertainty analysis for
    the doses estimated using the Techa River Dosimetry System -- 2000.
    *Health Phys.* 81:395405; 2001.

30. Peremyslova, L.M.; Kostyuchenko, V.A.; Degteva, M.O.; Baturin, V.A.;
    Popova, I.Ya.; Akleyev, A.V. The usage of current population
    exposure dose for justification of EURT area rehabilitation.
    *Radiat. Safety Problems* (Mayak Production Association Scientific
    Journal) 2:5054; 2001 (in Russian).

31. Phipps, A.W.; Tolstykh, E.I.; Shagina, N.B.; Harrison, J.D.;
    Degteva, M.O. The application and adaptation of ICRP internal
    dosimetry models to the calculation of bone marrow tissue doses from
    ^90^Sr for epidemiological studies of Techa River population.
    *Radiat. Biol. Radioecol.* 46:647-656; 2006.

32. Romanyukha, A.A.; Degteva, M.O.; Kozheurov, V.P.; Wieser, A.; Jacob,
    P.; Ignatiev, E.A.; Vorobiova, M.I. Pilot study of the Urals
    population by tooth electron paramagnetic resonance dosimetry.
    *Radiat. Environ. Biophys.* 35:305--310; 1996.

33. Romanyukha, A.A.; Ignatiev, E.A.; Degteva, M.O.; Kozheurov, V.P.;
    Wieser, A.; Jacob, P. Radiation doses from Ural region. *Nature*
    381:199--200; 1996.

34. Romanyukha, A.A.; Hayes, R.B.; Haskell, E.H.; Kenner, G.H.
    Geographic variations in the structure of the EPR spectrum of
    irradiated tooth enamel. *Radiat. Prot. Dosim.* 84:445--450; 1999.

35. Romanyukha, A.A.; Seltzer, S.M.; Desrosiers, M.; Ignatiev, E.A.;
    Ivanov, D.V.; Bayankin, S.; Degteva, M.O.; Eichmiller, F.C.; Wieser,
    A.; Jacob, P. Correction factors in the EPR dose reconstruction for
    residents of the middle and lower Techa Riverside. *Health Phys.*
    81:554--566; 2001.

36. Romanyukha, A.A.; Mitch, M.G.; Lin, Z.; Nagy, V.; Coursey, M.
    Mapping the distribution of 90Sr in teeth with a photostimulable
    phosphor imaging detector. *Radiat. Res.* 157:341--349; 2002.

37. Shagina, N.B.; Tolstykh, E.I.; Zalyapin, V.I.; Degteva, M.O.;
    Kozheurov, V.P.; Tokareva, E.E.; Anspaugh, L.R.; Napier, B.A.
    Evaluation of age and gender dependences of the rate of strontium
    elimination 25--45 years after intake: Analysis of data from
    residents living along the Techa River. *Radiat. Res.* 159:239--246;
    2003.

38. Shagina, N.B.; Tolstykh, E.I.; Degteva, M.O. Improvements in the
    biokinetic model for strontium with allowance for age and gender
    differences in bone mineral metabolism. *Radiat. Prot. Dosim.*
    105:619--622; 2003.

39. Shagina, N.B.; Bougrov, N.G.; Degteva, M.O.; Kozheurov, V.P.;
    Tolstykh, E.I. An application of in vivo whole body counting
    technique for studying strontium metabolism and internal dose
    reconstruction for the Techa River population. *Journal of Physics:
    Conference Series* 41:433-440; 2006.

40. Shagina, N.B.; Degteva, M.O.; Tolstykh, E.I.; Zalyapin, V.I.;
    Anspaugh, L.R.; Napier, B.A. Reduction of the uncertainties of the
    internal doses due to Strontium-90 for the Extended Techa River
    Cohort. *Radiat Safety Problems* (Mayak Production Association
    Scientific Journal) Special issue 1:525; 2006 (in Russian).

41. Shagina, N.B.; Tolstykh, E.I.; Fell, T.P.; Harrison, J.D.; Phipps,
    A.W.; Degteva, M.O. *In utero* and postnatal haemopoietic tissue
    doses resulting from maternal ingestion of strontium isotopes from
    the Techa River. *Radiat. Prot. Dosim.* 2007:1--5
    doi:10.1093/rpd/ncm357.

42. [Shibkova, D.Z.; Efimova, N.V.; Tolstykh, E.I.; Andreeva,
    O.G.](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15906859&query_hl=1&itool=pubmed_docsum)
    Compensatory adjustment of hemopoietic stem cell pool of CBA mice
    after acute intake of 90Sr. *Radiat. Biol. Radioecol.* 45:180--190;
    2005 (in Russian).

43. Shishkina, E.A.; Lyubashevskii, N.M.; Tolstykh, E.I.; Ignatiev,
    E.A.; Betenekova, T.A.; Nikiforov, S.V. A mathematical model for
    calculation of 90Sr absorbed dose in dental tissues: Elaboration and
    comparison to EPR measurements. *Appl. Radiat. Isot.* 55:363--374;
    2001.

44. Shishkina, E.A.; Degteva, M.O.; Shved, V.A.; Ivanov, D.V.; Bayankin,
    S.N.; Knyazev, V.A.; Vasilenko, E.K.; Smetanin, M.Y.; Gorelov, M.V.
    Problems and prospects of EPR researches in the Southern Urals.
    *Radiat. Safety Problems* (Mayak Production Association Scientific
    Journal) 2:5970; 2003 (in Russian).

45. Shishkina, E.A.; Göksu, H.Y.; El-Faramawy, N.A.; Semiochkina, N.
    Assessment of 90Sr concentration in dental tissue using thin-layer
    beta-particle detectors and verification with numerical
    calculations. *Radiat. Res.* 163:462-467; 2005.

46. Shishkina, E.A.; Degteva, M.O.; Tolstykh, E.I.; Shved, V.A.;
    Tokareva, E.E.; Ivanov, D.V.; Bayankin, S.N.; Wieser, A; Göksu,
    H.Y.; Anspaugh, L.R. Results of tooth dosimetric investigations for
    residents of the Techa Riverside region. *Radiat. Safety Problems*
    (Mayak Production Association Scientific Journal) Special
    issue1:2644; 2006 (in Russian).

47. Straume, T.; Anspaugh, L.R.; Haskell, E.H.; Lucas, J.N.; Marchetti,
    A.A.; Likhtarev, I.A.; Chumak, V.V.; Romanyukha, A.A.; Khrouch,
    V.T.; Gavrilin, Yu.I.; Minenko, V.A. Emerging technological bases
    for retrospective dosimetry. *Stem Cells* 15(Suppl.):183--193; 1997.

48. Taranenko, V.; Meckbach, R.; Degteva, M.O.; Bougrov, N.G.; Göksu,
    Y.; Vorobiova, M.I.; Jacob, P. Verification of external exposure
    assessment for the Upper Techa Riverside by luminescence
    measurements and Monte Carlo photon transport modeling. *Radiat.
    Environ. Biophys.* 42:17--26; 2003.

49. Tikunov, D.D.; Ivannikov, A.I.; Shishkina, E.A.; Petin, D.V.;
    Borysheva, N.B.; Orlenko, S.; Nalapko, M.; Shved, V.A.; Skvortsov,
    V.G.; Stepanenko, V.F. Complex experimental research on internal
    tooth dosimetry for the Techa River region: A model for 90Sr
    accumulation in human teeth formed by time of intakes. *Radiat.
    Meas.* 41:565-576; 2006.

50. Tolstykh, E.I.; Kozheurov, V.P.; Vyushkova, O.V.; Degteva, M.O.
    Analysis of strontium metabolism in humans on the basis of the Techa
    River data. *Radiat. Environ. Biophys.* 36:25--29; 1997.

51. Tolstykh, E.I.; Degteva, M.O.; Kozheurov, V.P.; Burmistrov, D.S.
    Strontium transfer from maternal skeleton to the fetus estimated on
    the basis of the Techa River data. *Radiat. Prot. Dosim.*
    79:307--310; 1998.

52. Tolstykh, E.I.; Degteva, M.O.; Kozheurov, V.P.; Shishkina, E.A.;
    Romanyukha, A.A.; Wieser, A.; Jacob, P. Strontium metabolism in
    teeth and enamel dose assessment: Analysis of the Techa River data.
    *Radiat. Environ. Biophys.* 39:161--171; 2000.

53. Tolstykh, E.I.; Degteva, M.O.; Shagina, N.B.; Kozheurov, V.P.;
    Repin, V.S.; Novak, N.Yu.; Berkovski, V.; Noßke, D. Biokinetic
    models for strontium: Estimation of reliability for the late period
    after intake. *Intl. J. Radiat. Med*. 3:133 (in English) and 301 (in
    Russian); 2001.

54. Tolstykh, E.I.; Degteva, M.O.; Peremislova, L.M.; Vorobiova, M.I.;
    Kozheurov, V.P. Dietary intake and 90Sr contents in the residents of
    the East Urals Radioactive Trace. Forty-year study experience.
    *Intl. J. Radiat. Med.* 3:134 (in English) and 300 (in Russian);
    2001.

55. Tolstykh, E.I.; Degteva, M.O.; Vorobiova, M.I.; Kozheurov, V.P.
    Fetal dose assessment for the offspring of the Techa Riverside
    residents. *Radiat. Environ. Biophys.* 40:279--286; 2001.

56. Tolstykh, E.I.; Degteva, M.O.; Vorobiova, M.I.; Kozheurov, V.P.;
    Peremislova, L.M. Dietary intake and 90Sr body contents in the
    residents of the Eastern Urals Radioactive Trace. Experience in the
    forty-year monitoring. *Intl. J. Radiat. Med.* 4:127‑133; 2002 (in
    English and Russian).

57. Tolstykh, E.I.; Degteva, M.O.; Shagina, N.B.; Kozheurov, V.P.;
    Repin, V.S.; Berkovski, V.; Noßke, D. Biokinetic models for
    strontium: Estimation of reliability for late period after intake*.
    Intl. J. Radiat. Med.* 4:134‑143; 2002 (in English and Russian).

58. Tolstykh, E.I.; Shishkina, E.A.; Degteva, M.O.; Ivanov, D.V.;
    Bayankin, S.N.; Anspaugh, L.R.; Napier, B.A.; Wieser, A.; Jacob, P.
    Age dependencies of 90Sr incorporation in dental tissues:
    Comparative analysis and interpretation of different kinds of
    measurements obtained for residents on the Techa River. *Health
    Phys.* 85:409--419; 2003.

59. Tolstykh, E.I.; Tokareva, E.E.; Peremyslova, L.M.; Degteva, M.O.
    Mineral content in different bones of the skeleton of Urals
    residents as a function of gender and age. *Morphol.* 125:72--75;
    2004 (in Russian).

60. Tolstykh, E.I.; Peremyslova, L.M.; Shagina, N.B.; Degteva, M.O.;
    Vorobiova, M.I.; Tokareva, E.E.; Safronova, N.G. Characteristics of
    90Sr accumulation and elimination for residents of the Urals region
    in 1957-1988. *Radiat. Biol. Radioecol.* 45:495-504; 2005 (in
    Russian).

61. Tolstykh, E.I.; Degteva, M.O.; Peremyslova, L.M.; Shagina, N.B.;
    Zalyapin, V.I.; Krivoschapov, V.A.; Anspaugh, L.R.; Napier, B.A.
    Reconstruction of long-lived radionuclide intakes for Techa
    Riverside residents. Part 1. Strontium-90. *Radiat. Safety Problems*
    (Mayak Production Association Scientific Journal) Special issue
    1:4567; 2006 (in Russian).

62. Tolstykh, E.I.; Degteva, M.O.; Vorobiova, M.I.; Peremyslova, L.M.;
    Shagina, N.B.; Anspaugh, L.R.; Napier, B.A. Reconstruction of
    long-lived radionuclide intakes for Techa Riverside residents.
    Part 2. Cesium-137. *Radiat. Safety Problems* (Mayak Production
    Association Scientific Journal) Special issue 1:6879; 2006 (in
    Russian).

63. Tolstykh, E.I.; Degteva, M.O.; Shishkina, E.A.; Zalyapin, V.I.;
    Krivoshchapov, V.A. Possibilities of using human teeth for
    retrospective dosimetry: Analysis of the Techa River data. *Radiat.
    Prot. Dosim.* 2007:1--5 doi:10.1093/rpd/ncm358.

64. Veronese, I.; Shved, V.; Shishkina, E.A.; Giussani, A.; Göksu, H.Y.
    Study of dose rate profile at sample disks in a Risø OSL
    single-grain attachment system. *Radiat. Meas.* 42:138--143; 2007.

65. Vorobiova, M.I.; Degteva, M.O.; Burmistrov, D.S.; Safronova, N.G.;
    Kozheurov, V.P.; Anspaugh, L.R.; Napier, BA. Review of historical
    monitoring data on Techa River contamination. *Health Phys.*
    76:605--618; 1999.

66. Vorobiova, M.I.; Degteva, M.O. Simple model for the reconstruction
    of radionuclide concentrations and radiation exposures along the
    Techa River. *Health Phys*. 77:142--149; 1999.

67. Wieser, A.; Romanyukha, A.A.; Degteva, M.O.; Kozheurov, V.P.;
    Petzold, G. Tooth enamel as a natural beta dosimeter for bone
    seeking radionuclides. *Radiat. Prot. Dosim.* 65:413--416; 1996.

68. Zalyapin, V.I.; Krivoshchapov, V.A. Numerical analysis of one
    inverse problem of applied biophysics. *Bull. Southern Urals State
    University*, Series 2 on Mathematics, Physics, and Chemistry №
    3:3--11; 2002 (in Russian).

69. Zalyapin, V.I.; Krivohchapov, V.A.; Degteva, M.O. Numerical analysis
    of an applied biophysics inverse problem. *Inverse Prob. Science
    Engin.* 12:379--392; 2004.

# Project 1.2a: Data Preservation at URCRM (1)

1.  Startsev, N.V.; Shalonin, D.G.; Cragle, D.; Klein, A.; Akleyev, A.V.
    Approach to physical preservation of archival records accumulated at
    the Urals Research Center for Radiation Medicine. *Med. Radiology
    and Radiation Safety* 6:107-112; 2001 (in Russian).

# Project 1.2b: Techa River Population Morbidity (22)

1.  Akleyev, A.V.; Kossenko, M.M.; Silkina, L.A.; Degteva, M.O.
    Clinical-epidemiological basis for identification of exposed
    population groups at high risk of cancer development. *Radiation and
    Risk* 5:163-182; 1995 (in Russian).

2.  Akleyev, A.V.; Kossenko, M.M.; Silkina, L.A.; Degteva, M.O.;
    Yachmenyov, V.A.; Awa, A.; Akiyama, M.; Veremeyeva, G.A.; Voziliva,
    A.V.; Kyazumi, S.; Kozheurov, V.P.; Vyushkova, O.V. Health effects
    of radiation incidents in the Southern Urals. *Stem Cells* 13:58-68;
    1995.

3.  Akleyev, A.V.; Kossenko, M.M.; Startsev, N.V. Techa River
    population: long-term medical follow-up. *British Journal of
    Radiology*, Supplement 26: 32-40; 2002.

4.  Akleyev, A.V.; Krestinina, L.Yu.; Preston, D. Carcinogenic effects
    of protracted radiation exposure among residents of the Techa river
    villages. *International Journal of Cancer* Suppl. 13:127-128; 2002.

5.  Akleyev, A.V.; Preston, D.; Krestinina, L.Yu. Medical-biological
    effects of chronic radiation exposure in man. *Occupational medicine
    and Industrial Ecology* 3:30-36; 2004 (in Russian).

6.  Akleyev, A.V.; Zhidkova, C. The Chelyabinsk data base: current
    Russian legislation on database and intellectual property and its
    implications for international scientific collaboration. *Health
    Physics* 71:58-60; 1996.

7.  Burmistrov, D.; Kossenko, M.; Wilson, R. Radioactive contamination
    of the Techa River and its effects. *Technology* 7:553*--*575; 2000.

8.  Ilyin, L.A.; Akleyev, A.V.; Romanov, S.A. Progress in radiobiology
    research and radiation medicine achieved by institutes within the
    system of Federal Medical and Biological Agency of Russia.
    *Emergency Medicine* 21:68-82; 2007 (in Russian).

9.  Kossenko, M.M. Cancer mortality in the exposed population of the
    Techa River area. *World Health Stat. Q*. 49(1):17*--*21; 1996.

10. Kossenko, M.M. Cancer mortality among Techa river residents and
    their offspring. *Health Phys*. 71(1):77*--*82; 1996.

11. Kossenko, M.M.; Degteva, M.O.; Vyushkova, O.V.; Preston, D.L.;
    Mabuchi, K.; Kozheurov, V.P. Issues in the comparison of risk
    estimates for the population in the Techa River Region and Atomic
    Bomb Survivors. *Radiat. Res*. 148:54*--*63; 1997.

12. Kossenko, M.M.; Degtyaryova, R.G.; Petrushova, N.A. Clinical and
    epidemiological characteristics of leukemia cases among population
    exposed to chronic irradiation. *Hematology and Transfusiology*
    42(2):27*--*31; 1997 (in Russian).

13. Kossenko, M.M.; Akleyev, A.V.; Startsev, N.A.; Degteva, M.O.
    Epidemiological analysis of remote carcinogenic effects on
    populations with chronic exposure to radiation in the Urals region.
    *Int. J. Radiat. Med.* 2(2):34*--*41; 1999.

14. Kossenko, M.M.; Hoffman, D.A.; Thomas, T.L. Stochastic effects of
    environmental radiation exposure in populations living near the
    Mayak Industrial Association: preliminary report on study of cancer
    morbidity. *Health Phys*. 79:55*--*62; 2000.

15. Kossenko, M.M.; Ostroumova, E.V.; Krestinina, L.Yu.; Vyushkova,
    O.V.; Epifanova, O.V.; Gudkova, N.V.; Thomas, T.L.; Hoffman, D.A.;
    Preston, D.L.; Akleyev, A.V. Analysis of Cancer morbidity among the
    exposed residents of the Techa riverside villages. *Meditsinskaia
    Radiologiya i Radiatsionnaya Bezopasnost* (Medical Radiology and
    Radiation Safety), V. 46, *№*6 Moscow, Radekon, 2001 (in Russian).

16. Kossenko, M.M.; Preston, D.L.; Krestinina, L.Y.; Degteva, M.O.;
    Startsev, N.V.; Thomas, T.L.; Vyushkova, O.V.; Anspaugh, L.R.;
    Napier, B.A.; Kozheurov, V.P.; Ron, E.; Akleyev, A.V. Studies on the
    extended Techa River cohort: cancer risk estimation. *Radiat.
    Environ. Biophys.* 41:45--48; 2002.

17. Kossenko, M.M.; Akleyev, A.V.; Krestinina, L.Yu.; Startsev, N.V.;
    Zhidkova, C.; Hoffman, D.A.; Thomas, T.L.; Preston, D. Methods for
    following-up a cohort of people exposed on the Techa River.
    *Siberian Medical Journal* 18:40-49; 2003 (in Russian).

18. Kossenko, M.M.; Thomas, T.L.; Akleyev, A.V.; Krestinina, L.Y.;
    Startsev, N.V.; Vyushkova, O.V.; Zhidkova, C.M.; Hoffman, D.A.;
    Preston, D.L.; Davis, F.; Ron, E. The Techa River Cohort: Study
    Design and Follow-up Methods.
    [http://www.bioone.org/bioone/?request=get-abstract&doi=10.1043/0033-7587(2005)164\[0591:TTRCSD\]2.0.CO;2](http://www.bioone.org/bioone/?request=get-abstract&doi=10.1043/0033-7587(2005)164[0591:TTRCSD]2.0.CO;2).
    *Radiat. Res.* 164:591-601; 2005.

19. Krestinina, L.Yu.; Preston, D.; Ostroumova, E.V.; Ron, E.;
    Vyushokova, O.V.; Akleyev, A.V. Cancer mortality in a cohort of
    people exposed on the Techa River: preliminary risk estimation.
    *Siberian Medical Journal* 2:52-62; 2005 (in Russian).

20. Krestinina, L.Y.; Preston, D.L.; Ostroumova, E.V.; Degteva, M.O.;
    Ron, E.; Vyushokova, O.V.; Startsev, N.V.; Kossenko, M.M., Akleyev,
    A.V. Protracted Radiation Exposure and Cancer Mortality in the Techa
    River Cohort.
    [http://www.bioone.org/bioone/?request=get-abstract&doi=10.1043/0033-7587(2005)164\[0602:PREACM\]2.0.CO;2](http://www.bioone.org/bioone/?request=get-abstract&doi=10.1043/0033-7587(2005)164[0602:PREACM]2.0.CO;2).
    *Radiat. Res.* 164:602-611; 2005.

21. Krestinina, L.Y.; Davis F.; Ostroumova, E.V.; Epifanova, S.B.;
    Degteva, M.O.; Preston, D.L.; Akleyev, A.V. Solid cancer incidence
    and low-dose-rate radiation exposures in the Techa River cohort:
    1956--2002. *International Journal of Epidemiology*
    36:1038--1046; 2007.
    PDF:<http://ije.oxfordjournals.org/cgi/reprint/dym121?ijkey=SfOmBABjefzUDBW&keytype=ref>

22. Segerstahl, B.; Akleyev, A.V.; Novikov, V. The long shadow of Soviet
    plutonium production. *Environment* 39:12-20; 1997.

# Project 1.4: Reconstruction of Dose to Residents of Ozersk from Mayak Operations (2)

1.  Glagolenko, Y.V.; Drozhko, E.G.; Mokrov, Y.G.; Rovny, S.I.;
    Stukalov, P.M.; Lyzhkov, A.V.; Alexandrova, O.N. Assessment of
    effective cooling period for irradiated uranium in reactor "A"
    storage pool in 1948--1954. *Radiat. Safety Problems* (Mayak
    Production Association Scientific Journal) 3:75-79; 2006 (in
    Russian).

2.  Report of the First Central Directorate Committee Under the Guidance
    of Alexandrov, A.P. Concerning Contamination of the Territory
    Adjacent to Mendeleev Plant (1951). *Radiat. Safety Problems* (Mayak
    Production Association Scientific Journal) 3: 60-74; 2006 (in
    Russian).

**Project 2.2: Mayak Worker Epidemiology (6)**

1.  Gilbert, E.S.; Koshurnikova, N.A.; Sokolnikov, M.; Khokhryakov,
    V.F.; Miller, S.; Preston, D.L.; et al: Liver Cancers in Mayak
    Workers. *Radiat. Res.* 154:246*--*252; 2000.

2.  Gilbert, E.S.; Koshurnikova, N.A.; Sokolnikov, M.E.; Shilnikova,
    N.S.; Preston, D.L.; Ron, E.; Khokhryakov, V.F.; Vasilenko, E.K.;
    Miller, S.; Eckerman, K.; Romanov, S.A. Lung cancers in Mayak
    workers. *Radiat. Res.*, 162:505*--*516; 2004.

3.  Koshurnikova, N.A.; Gilbert, E.S.; Sokolnikov. M.; Khokhryakov,
    V.F.; Miller, S.; Preston, D.L.; et al: Bone Cancers in Mayak
    Workers. *Radiat. Res.* 154:237*--*245; 2000.

4.  Koshurnikova, N.A.; Gilbert, E.S.; Shilnikova, N.S.; Sokolnikov, M.;
    Preston, D.L.; Kreisheimer, M.; Ron, E.; Kellerer, A.M.; Okatenko,
    P.; Romanov, S.A. Studies on the Mayak nuclear workers: health
    effects. *Radiation and Environmental Biophysics* 41:29*--*31; 2002.

5.  Shilnikova, N.A.; Preston, D.L.; Ron, E.; Gilbert, E.S.; Vasilenko,
    E.K.; Romanov, S.A.; Kuznetsova, I.S.; Sokolnikov, M.E.; Okatenko,
    P.V.; Kreslov, V.V.; Koshurnikova, N.A. Cancer mortality risk among
    workers at the Mayak nuclear complex.  *Radiat. Res.*
    159:787*--*798; 2003.

6.  Koshurnikova, N.A.; Shilnikova, N.S.; Sokolnikov, M.E.; Bolotnikova,
    M.G.; Okatenko, P.V.; Kuznetsova, I.S. Medical-Dosimetry registry of
    workers at the \"Mayak\" production association. *International
    Journal of Low Radiation* 2:236-242; 2006.

# Project 2.4: Mayak Worker Dosimetry (46)

1.  Bailey, B.R.; Eckerman, K.F.; Townsend, L.W. An analysis of a
    puncture wound case with medical intervention. *Radiat. Prot.
    Dosim.* 105:509-512; 2003.

2.  Bess, J.D., Krahenbuhl, M.P., Miller, S.C., Khokhryakov, V.V.,
    Khokhryakov, V.F., Suslova, K.G., Vostrotin, V.V. Uncertainties
    analysis for the plutonium dosimetry model, doses 2005, using Mayak
    bioassay data. *Health Physics* 93:207-219; 2007.

3.  Choe, D.O.; Shelkey, B.N.; Wilde, J.L.; Walk, H.A.; Slaughter D.A.
    Calculated organ doses for Mayak production association central hall
    using ICRP and MCNP. *Health Physics* 84:317-321; 2003.

4.  Ilyin, L.A.; Kiselev, M.F.; Panfilov, A.P.; Kochetkov, O.A.; Ivanov,
    A.A.; Grinev, M.P.; Soloviev, V.Yu.; Semenov, V.G.; Tukov, A.R.;
    Romanov, S.A.; Koshurnikova, N.A.; Khokhryakov, V.F.; Kuznetsova,
    I.S. Medical dosimetric registry of Russian atomic industry
    employees: current status and perspectives. *Int. J. of Low
    Radiation* 2:207-218; 2006.

5.  Jacob, P.; Meckbach, R.; Sokolnikov, M.; Khokhryakov, V.V.;
    Vasilenko, E. Lung cancer risk of Mayak workers: modeling of
    carcinogenesis and bystander effect. *Radiat. Environ Biophys.*
    46:383-394, 2007.

6.  Khokhryakov, V.F.; Kellerer, A.M.; Kreisheimer, M.; Romanov, S.A\...
    Lung Cancer in Nuclear Workers of Mayak. A Comparison of Numerical
    Procedures. *Radiat. Environ. Biophys.* 37:11--17; 1998.

7.  Khokhryakov, V.; Suslova, K.; Aladova, E.; Vasilenko, E.; Miller,
    S.C.; Slaughter, D.M.; Krahenbuhl, M.P. Development of an improved
    dosimetry system for the workers at the Mayak Production
    Association. *Health Phys*. 79:72--76; 2000.

8.  Khokhryakov, V.; Suslova, K.; Romanov, S.; Vostrotin, V. Pulmonary
    Clearance of Industrial Plutonium Compounds in remote Period after
    the Beginning of Inhalation. *Medical Radiology and Radiation
    Protection* 2:28--34; 2000.

9.  Khokhryakov, V.F.; Suslova, K.G.; Vostrotin, V.V.; Romanov, S.A.;
    Menshikh, Z.S.; Kudryavtseva, T.I.; Miller, S.C.; Krahenbuhl, M.P.;
    Filipy, R.E. The development of the plutonium lung clearance model
    for exposure estimation of the Mayak PA, nuclear plant workers.
    *Health Physics* 82:425--431; 2002.

10. Khokhryakov, V.F.; Chernikov, V.I.; Efimov, A.E. The use of
    scintillation body counter for monitoring of actinide accumulation
    among Mayak PA personnel. *Radiation Safety* (Special issue) 64-70;
    2003 (article in Russian).

11. Khokhryakov, V.F.; Kudryavtseva ,T.I.; Schadilov, A.E.; Shalaginov,
    A.I. Successful DTPA therapy in the case of 239Pu penetration via
    injured skin exposed to nitric acid. *Radiat. Prot. Dosim.*
    105:499-502; 2003.

12. Khokhryakov, V.F.; Vasilenko, E.K. Dosimetry register of Mayak PA
    personnel -- one of the major world information sources for solution
    of fundamental radiation safety problems. *Radiation Safety
    Problems* (Special Issue) 36-40; 2003 (article in Russian).

13. Khokhryakov, V.F. "Doses-1999, 2000" are serial improvements of
    plutonium dosimetry for Mayak PA workers. *Radiation Safety
    Problems* 1: 71- 82; 2004 (article in Russian).

14. Khokhryakov, V.F.; Suslova, K.G.; Kudravtseva, T.I.; Schadilov,
    A.E.; Vostrotin, V.V.; Lagounova, N.Y.; Barabanshchikova, A.Y.
    Precision of equations for systemic Pu excretion based on new data
    on nuclide removing with urine and feces at late times after
    inhalation. *Medical Radiology and Radiation Safety* 4:12-20; 2004
    (article in Russian).

15. Khokhryakov, V.F.; Suslova, K.G.; Kudryavtseva, T.I.; Schadilov,
    A.E.; Vostrotin, V.V.; Lagounova, N.Yu.; Barabanshchikova, A.Yu.
    Relative role of plutonium excretion with urine and feces from the
    human body. *Health Physics* 86:523--527; 2004.

16. Khokhryakov, V.F.; Suslova, K.G.; Vostrotin, V.V.; Romanov, S.A.;
    Eckerman, K.F.; Krahenbuhl, M.P.; Miller, S.C. Adaptation of the
    ICRP Publication 66 respiratory tract model to data on plutonium
    biokinetics for Mayak workers. *Health Phys*. 88:125-132; 2005.

17. Khokhryakov, V.F. Graphical method for assessment of doses and level
    accumulation based on urine excretion data. *Medical Radiology and
    Radiation Safety* 5:5-14; 2005 (in Russian).

18. Khokhryakov, V.V.; Efimov, A.V. Americium-241 as the factor of
    internal exposure to Mayak PA workers. *Radiation Safety Problems*,
    1: 94-104; 2006 (article in Russian).

19. Khokhryakov, V.F.; Khokhryakov, V.F.; Suslova, K.G.; Efimov, A.V.;
    Vostrotin, V.V., Schadilov, A.E. Status and prospects of internal
    dosimetry for the Mayak nuclear workers. *Int. J. of Low Radiation*
    2:219-235; 2006.

20. Khokhryakov, V.F, ; Khokhryakov, V.V. ; Suslova, K.G.; Vostrotin,
    V.V. ; Schadilov, A.E.; Sokolova, A.B.; Efimov, A.V. ; Krahenbuhl,
    M.P.; Miller, S.C.; Eckerman, K.F.; Leggett, R.W.. Progress in
    plutonium dosimetry development at Mayak PA. *Radiation Safety
    Problems* 1:58-79; 2006 (article in Russian).

21. Khokhryakov, V.V.; Efimov, A.V. Experience in application of whole
    body counting technique to control 241Am body burden in the Mayak PA
    workers. *Radiation Safety Issue.* 1:57-70; 2004 (article in
    Russian).

22. Khokhryakov, V.V.; Lagunova, N.Yu.; Sypko, S.A.; Rumyantseva, E.Yu.
    Investigation on effects of the dispersed composition of industrial
    aerosols on plutonium dialysis kinetics. *Siberian Medical Journal*
    2:99-104; 2005 (in Russian).

23. Khokhryakov, V.V, ; Khokhryakov, V.F. ; Suslova, K.G.; Sokolova,
    A.B. Time history analysis for isotopic composition of actinides
    inhaled by Mayak PA workers during 1949-2000. *Radiation Safety
    Journal* 3:58-65; 2007 (article in Russian)

24. Krahenbuhl, M.P.; Slaughter, D.M.; Wilde, J.L.; Bess, J.D.; Miller,
    S.C.; Khokhryakov, V.K.; Suslova, K.G.; Vostrotin, V.V.; Romanov,
    S.A.; Menshikh, Z.S.; Kudryavtseva, T.I. The historical and current
    application of the FIB-1 model to assess organ dose from plutonium
    intakes in Mayak workers. *Health Physics* 82:445--45; 2002.

25. Krahenbuhl, M.P.; Bess, J.D.; Wilde, J.L.; Vostrotin, V.V.; Suslova,
    K.G.; Khokhryakov, V.F.; Slaughter, D.M.; Miller, S.C. Uncertainties
    analysis of doses resulting from chronic inhalation of plutonium at
    the Mayak Production Association. *Health Phys.* 89:33-45; 2005.

26. Kreisheimer, M.E.; Sokolnikov, M.E.; Koshurnikova, N.A.;
    Khokhryakov, V.F.; Romanov, S.A.; Shilnikova, N.S.; Okatenko, P.V.;
    Nekolla, E.A.; Kellerer, A.M. Lung cancer mortality among nuclear
    workers of the Mayak facilities in the former Soviet Union. *Radiat.
    Environ. Biophys*. 42: 120-135; 2003.

27. Kudryavtseva, T.I.; Sokolova, A.B. Macrodistribution of Pu
    industrial compounds in human lung. Radiation Safety Problems
    3:41-48; 2005 (in Russian).

28. Leggett, R.W. Reliability of the ICRP's dose coefficients for
    members of the public. III. Plutonium as a case study of
    uncertainties in the systemic biokinetics of radionuclides.
    *Radiation Protection Dosimetry* 106:103-120; 2003.

29. Leggett, R.W.; Eckerman, K.F.; Khokhryakov, V.F.; Suslova, K.G.;
    Krahenbuhl, M.P.; Miller, S.C. Mayak worker study: An improved
    biokinetic model for reconstructing doses from internally deposited
    plutonium. *Radiat. Res.* 164:111-122; 2005.

30. Miller, S.C. Radionuclide-induced skeletal cancers. *J. Musculoskel.
    Neuron. Interact.* 2:552-553; 2002.

31. Miller, S.C.; Lloyd, R.D.; Bruenger, F.W.; Krahenbuhl, M.P.; Polig,
    E.; Romanov, S.A. Comparisons of the skeletal locations of putative
    plutonium-induced osteosarcomas in humans with those in Beagle dogs
    and with naturally-occurring tumors in both species. *Radiation
    Research* 160:517--523; 2003.

32. Okladnikova, N.D.; Khokhryakov, V.V.; Shevkunov, V.A.; Pesternikova,
    V.C. 239Pu: clinico-cytogenetic description of high-incorporation
    case. (24 years of observations). *Radiation Biology and
    Radioecology* 44: 415-419; 2004 (article in Russian).

33. Okladnikova, N.D.; Scott, B.R.; Tokarskaya, Z.B.; Zhuntova, G.V.;
    Khokhryakov, V.F.; Syrchicov, V.A.; Grigoryeva, E.S. Chromosomal
    aberrations in lymphocytes of peripheral blood among Mayak facility
    workers who inhaled insoluble forms of 239Pu. *Radiat. Prot.
    Dosimetry* 113 (1):3-13, 2005.

34. Romanov, S.A.; Vasilenko, E.K.; Khokhryakov, V.F.; Jacob, P. Studies
    on the Mayak nuclear workers: dosimetry. *Radiat. Environ. Biophys.*
    41:23-28, 2002.

35. Schadilov, A.E.; Khokhryakov, V.F.; Kudravtseva, T.I.; Vostrotin,
    V.V. "DTPA effects on plutonium excretion from human body".
    *Siberian Medical Journal* 2:128-132; 2005 (in Russian).

36. [Smetanin,
    M](http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Smetanin M"%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus);
    [Vasilenko,
    E.K](http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Vasilenko EK"%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus).,
    [Lyubarskaya,
    I](http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Lyubarskaya I"%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus).;
    [Knyazev,
    V](http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Knyazev V"%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus).;
    [Gorelov,
    M](http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Gorelov M"%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus).;
    [Scherpelz,
    R.I](http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Scherpelz RI"%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus).,;
    [Fix,
    J.J](http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Fix JJ"%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus).
    Mayak film dosimeter response studies, part II: response models.
    [*Health Phys.*](javascript:AL_get(this, 'jour', 'Health Phys.');)
    93: 231-238, 2007.

37. [Smetanin
    M](http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Smetanin M"%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus),
    [Vasilenko
    EK](http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Vasilenko EK"%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus),
    [Scherpelz
    RI](http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Scherpelz RI"%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus).
    Mayak film dosimeter response studies, part iii: application to
    worker dose assessment. [*Health
    Phys.*](javascript:AL_get(this, 'jour', 'Health Phys.');) 93:
    239-244, 2007.

38. Sokolnikov, M.E.; Khokhryakov, V.F.; Vasilenko, E.K.; Koshurnikova,
    N.A. Risk of lung cancer development in the personnel exposed to
    internal radiation as a result of incorporated Pu. *Siberian Medical
    Journal* 5:31-36; 2003 (in Russian).

39. Suslova, K.; Khokhryakov, V.; Tokarskaya, Z.; Kudryavtseva, T.;
    Nifatov, A. Distribution of Plutonium in Organs of Extrapulmonary
    Pool in Remote Periods after the Beginning of Inhalation in Workers
    of Radiochemical Plant. *Medical Radiology and Radiation Protection*
    1:17--25; 2000.

40. Suslova, K.G.; Khokhryakov, V.F.; Tokarskaya, Z.B.; Nifatov, A.P.;
    Krahenbuhl, M.P.; Miller, S.C. Extrapulmonary organ distribution of
    plutonium in healthy workers exposed by chronic inhalation at the
    Mayak Production Association. *Health Physics* 82:432--444; 2002.

41. Suslova, K.G.; Khokhryakov, V.F.; Tokarskaya, Z.B.; Nifatov, A. P.;
    Sokolova, A.B; Miller, S.C.; Krahenbuhl, M.P. The effect of state of
    health on organ distribution and excretion of systemic plutonium in
    the Mayak workers. *Radiation Protection Dosimetry* 105:229--233;
    2003.

42. Suslova, K.G.; Khokhryakov, V.F.; Nifatov, A.P.; Sokolova, A.B.
    Smoking and Lung Diseases as the Modifying Factors of Plutonium
    Distribution in the Respiratory Tract at the Late Times of Clearance
    in Workers of the Radiochemical Plant. *Medical Radiology and
    Nuclear Safety* 3:10-21; 2006 (in Russian).

43. Suslova, K.G.; Khokhryakov, V.F.; Tokarskaya, Z.B.; Nifatov, A. P.;
    Sokolova, A.B; Miller, S.C. and Krahenbuhl, M.P. Modifying effects
    of health status, physiological, and dosimetric factors on
    extrapulmonary organ distribution and excretion of inhaled plutonium
    in workers at the Mayak Production Association. *Health Physics*
    90:299-311; 2006.

44. [Vasilenko
    EK](http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Vasilenko EK"%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus),
    [Knyazev
    V](http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Knyazev V"%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus),
    [Gorelov
    M](http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Gorelov M"%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus),
    [Smetanin
    M](http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Smetanin M"%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus),
    [Scherpelz
    RI](http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Scherpelz RI"%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus),
    [Fix
    JJ](http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Fix JJ"%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus).
    Mayak film dosimeter response studies, part I: measurements.
    [*Health Phys.*](javascript:AL_get(this, 'jour', 'Health Phys.');)
    93: 220-230; 2007.

45. Vasilenko, E.K., Khokhryakov, V.F, Miller, S.C., Fix, J.J.,
    Eckerman, K., Choe, D.O., Gorelov, M., Khokhryakov, V., Knyazev, V.,
    Krahenbuhl, M.P., Scherpelz, R.I., Smetanin, M., Suslova, K.,
    Vostrotin. Mayak worker dosimetry study: An overview. *Health
    Physics* 93:190-206; 2007.

46. Vasilenko, E.K. Smetanin, M.Y., Miller, S.C. Slaughter, M., Jacob,
    P., Feherbaher, G. Approach to retrospective reconstruction of the
    photon exposure spectra distribution at technological sites of the
    Mayak Production Association. *Radiation Safety Problems* (Russian
    Federal Ministry of Atomic Energy) 3:42--50; 2000 (in Russian).

# Project 2.5: Improved Plutonium Dose Assessment Methods for Mayak Workers (8)

1.  Guilmette, R.A.; Romanov, S.A.; Hahn, F.F.; Nifatov, A.P.;
    Muksinova, K.N.; Zaytseva, Y.V. Assessing the Uniformity of
    Plutonium Alpha Radiation Dose in Human Lung: The Mayak Experience.
    *Radiation Protection Dosimetry* 99:457*--*461; 2002.

2.  Hahn, F.F.; Romanov, S.A.; Guilmette, R.A.; Nifatov, A.P.; Zaytseva,
    Y.; Diel, J.H.; Allen, S.W.; Lyovkina, Y.V. Distribution of
    Plutonium in Particles in the Lungs of Mayak Workers. *Radiat.
    Protect. Dosim.* 105:81*--*84; 2003.

3.  Hahn, F.F.; Romanov, S.A.; Guilmette, R.A.; Nifatov, A.P.; Diel,
    J.A.; Zaytseva, Y.V.  Plutonium Microdistribution in the Lung of
    Mayak Workers. *Radiat. Res.* 161, 568*--*581; 2004.

4.  Romanov, S.A.; Hahn, F.F.; Guilmette, R.A.; Nifatov, A.P.;
    Muksinova, K. N.; Zaytseva, Y.V. Using a Microdosimetric Approach to
    Improve Dosimetry of Lung Exposure to Internally Deposited
    Plutonium. *Medical Radiology and Radiation Safety.* 6:58*--*65;
    2001(article in Russian).

5.  Romanov, S.A.; Guilmette, R.A.; Hahn, F.F.; Nifatov, A.P.; Zaytseva,
    Y.V.; Lyovkina, Y.V. Improved Lung Dosimetry Using Plutonium
    Microdistribution Studies. *Radiat. Protect. Dosim*. 105: 85*--*90;
    2003.

6.  Romanov, S.A.; Vasilenko, E.K.; Khokhryakov, V.F.; Jacob, P. Studies
    on the Mayak Nuclear Workers: Dosimetry. *Radiat. Environ. Biophys.*
    41: 23-28; 2002..

7.  Romanov, S.A.; Zaytseva, Y.V. Dosimetry of Internal Exposure of
    Respiratory Tract to Incorporated Plutonium. *Int. J. Low Radiation*
    2 (3/4): 257 -- 262; 2006.

8.  Romanov, S.A.; Zaytseva, Y.V.; Nifatov, A.P.; Lyovkina, Y.V.; Hahn,
    F.F.; Guilmette, R.A. Microdistribution of Plutonium-239 in the
    Lungs. *Siberian Medical Journal* 18 (5): 112-118; 2003 (article in
    Russian).

# Project 2.6: Molecular Markers of Lung Cancer in Mayak Workers (4)

1.  Belinsky, S.A.; Klinge, D.M.; Liechty, K.C.; March, T.H.; Kang, T.;
    Gilliland, F.D.; Sotnic, N.; Adamova, G.; Rusinova, G.; Telnov, V.
    Plutonium targets the p16 gene for inactivation by promoter
    hypermethylation in human lung adenocarcinoma. *Carcinogenesis* 25:
    1063--1067; 2004.

2.  Lyon, C. M.; Klinge, D.M.; Liechty, K.C.; Gentry, F.D.; March, T.H.;
    Kang, T.; Gilliland, F.D.; Adamova, G.; Rusinova, G.; Telnov, V.;
    Belinsky, S.A. Radiation induced lung adenocarcinoma is associated
    with increased frequency of genes inactivated by promoter
    hypermethylation. *Radiation Res.* 168: 409-414; 2007.

3.  Telnov, V.I.; Rusinova, G.G.; Adamova, G.V.; Belinsky, S.A.;
    Crowell, R.E.; Nikula, K.J. Molecular-epidemiological study of lung
    cancer in workers of atomic industry. *Medical radiology and
    Radiation safety* 46:94*--*97; 2001 (in Russian).

4.  Telnov, V.I.; Belinsky, S.A.; Rusinova, G.G.; Crowell, R.E.; Sotnic,
    N.V.; Adamova, G.V. Molecular markers of lung cancer in atomic
    industry workers. *Radiation Safety problems* 4:36*--*41; 2002 (in
    Russian).

# Project 2.7: Radiation Biomarkers (5)

1.  Brenner, D.J.; Okladnikova, N.; Hande, P.; Burak, L.; Geard, C.R.;
    Azizova, T. Biomarkers Specific to Densely Ionizing (High-LET)
    Radiations. *Radiat. Protec. Dosim.* 97, 69*--*73; 2001.

2.  Brenner, D.J. Comments on "Chromosome intrachanges and interchanges
    detected by multicolor banding in lymphocytes: Searching for
    clastogen signatures in the human genome."   *Radiat Res.* 162:600;
    2004.

3.  Hande, M.P.; Azizova, T.V.; Geard, C.R.; Burak, L.E.; Mitchell,
    C.R.; Khokhryakov, V.F.; Vasilenko, E.K.; Brenner, D.J. Past
    exposure to densely ionizing radiation leaves a unique permanent
    signature in the genome. *Am. J. Hum. Genet.* 72:1162*--*70; 2003.

4.  Hande, M.P.; Azizova, T.V.; Burak, L.E.; Khokhryakov, V.F.; Geard,
    C.R.; Brenner, D.J. Complex Chromosome Aberrations Persist in
    Individuals Many Years after Occupational Exposure to
    Densely-Ionizing Radiation: An mFISH Study. *Genes, Chromosomes,
    Cancer* 44:1-9 (2005).

5.  Mitchell, C.R.; Azizova, T.V.; Hande, P., Burak, L.E.; Tsakok, J.M.;
    Khokhryakov, V.F.; Geard, C.R.; Brenner, D.J. Stable
    intra-chromosomal biomarkers of past exposure to densely-ionizing
    radiation in several chromosomes of exposed individuals. *Radiat.
    Res.* 162:600; 2004.

# Project 2.8: Mayak Worker Tissue Repository (8)

1.  Akleyev, B.; Grosche, B.; Gusev, V.; Kiselev, M.; Kisselev, B.;
    Kolyado, S.; Romanov, S.; Shoikhet, Y.; Neta, R. Developing
    additional resources. *Radiation and Environmental Biophysics*
    41:13*--*18; 2002.

2.  Kirillova, E.N.; Muksinova, K.N.; Ezhova, A.V.; Sokolova, S.N.
    Establishment of human immortalized b-lymphocytes bank: Prospects of
    application. *Immunology* 25:196*--*197; 2004.

3.  Muksinova K.N.; Neta R.; Kirillova E.N.; Revina V.S.; Sokolova,
    S.N.; Kreslov, V.V.; Suslova, K.G.; Zacharova, M.L.; Nifatov, A.P.;
    Uryadnitskaya, T.I.; Drugova, E.D.; Rybkina, V.L. Establishment of
    Russian Human Radiobiology Tissue Repository. *Medical Radiology and
    Radiation Safety* 46:98-106; 2001.

4.  Muksinova, K.N.; Neta, R.; Kirillova, E.N..; Sokolova, S.N.;
    Zakharova, M.L.; Revina, V.S.; Drougova, E.D.; Rybkina, V.L.;
    Uryadnitskaya, T.I.; Yezhova, A.V. Biological material repositorium
    of personnel of the first atomic enterprise of Russia. *Siberian
    Medical Journal* 18:84*--*89; 2003 (in Russian).

5.  Muksinova, K.N.; Revina, V.S; Kirillova, E.N; Zakharova, M.L.;
    Drugova, E.D.; Neta, R. Radiobiological characteristics of the tumor
    tissue bank of first Russian nuclear weapon facility professionals.
    *Medical Radiology and Radiation Safety* 51:44-51; 2006.

6.  Muksinova K.; Kirillova, E.; Zakharova, M.; Revina, V.; Neta R.
    Bio-specimens Repository from Mayak workers exposed to protracted
    radiation. *Health Physics* 90:263-265; 2006.

7.  Neta, R. The promise of molecular epidemiology in defining the
    association between radiation and cancer. *Health Physics*
    79:77*--*84; 2000.

8.  Russell, J.J.; Muksinova, K.N.; Kathren, R.L.   Establishment of a
    Repository containing tissues of organs of deceased workers of Mayak
    Industrial association exposed to actinide elements.  *Health Phys*,
    76 (6). Suppl. 152-153; 1999.

 

# Project 2.9: Database Integration (0)

None.