September, 2007

> CURRICULUM VITAE

[NAME]{.underline}: Dolph Lee Hatfield

[Place of Birth]{.underline}: El Paso, Texas

[Citizenship]{.underline}: United States

[Marital Status]{.underline}: Married

[Education]{.underline}:

Jan, 1955 Graduated from High School

June, 1958 B.A. (Biology), University of Texas at Austin

June 1960 M.A. (Biology), University of Texas at Austin

Jan., 1962 Ph.D. Biology, University of Texas at Austin (Thesis: Part I:
Uric

acid riboside; Part II: New naturally occurring pteridines)

[Brief Chronology of Employement]{.underline}:

Jan. 1958-Sept. 1958 Research Assistant, University of Texas at Austin

Sept. 1958-Jan. 1962 Welch Foundation Scholarship

Feb. 1960-July 1960 Teaching Assistant, Department of Zoology,

University of Texas at Austin

Feb. 1961-July 1961 Teaching Assistant, Department of Zoology,

University of Texas at Austin

Jan. 1961-July 1962 Postdoctoral Fellow, Genetics Foundation,

University of Texas at Austin

(Above positions in the laboratory of Dr. H.

S. Forrest)

July 1962-July 1964 PHS Fellow, Department of Biochemistry,

Duke University Medical Center

(Laboratory of Dr. James B. Wyngarden)

July 1964-July 1966 American Cancer Society Postdoctoral

Fellow, National Heart Institute, NIH

(Laboratory of Dr. Marshall W. Nirenberg)

July 1966-Nov. 1966 Research Staff, National Heart Institute

Dec. 1966-Dec. 1967 PHS Postdoctoral Fellow, NCI, NIH, Institut

Pasteur, Paris, France

(Laboratory of Dr. Jacques Monod)

# Curriculum Vitae -- Dolph L. Hatfield -- Page 2

Dec. 1967-Feb. 1986 Research Biologist, Laboratory of Molecular

Carcinogenesis, DCE, National Cancer

Institute

Feb. 1986-July 1996 Research Biologist, Laboratory of

Experimental Carcinogenesis, DCE,

National Cancer Institute

July 1996-Dec. 2003 Chief, Section of the Molecular Biology of

Selenium, Basic Research Laboratory

Center for Cancer Research

Division of Basic Sciences

National Cancer Institute

(Laboratory of Dr. Douglas Lowy)

Dec. 2003-Present Chief, Section of the Molecular Biology of

Selenium, Laboratory of Cancer Prevention

Center for Cancer Research

Division of Basic Sciences

National Cancer Institute

(Laboratory of Dr. Nancy Colburn)

## 

## Research Interests:

### Role of selenium in health, specifically in the ability of this unique element to prevent cancer and heart disease and to delay the aging process; the mechanism whereby selenium becomes covalently bound in protein which involves selenocysteine tRNA and the biosynthesis of selenocysteine; and the development of mouse models to examine the molecular role of selenium and selenoproteins in health.

[Recent Awards]{.underline}

2006 National Institutes of Health Graduate School Student Community
Outstanding Mentor Award.

2006 National Cancer Institute Mentor of Merit Award for Excellence in
Mentoring and Guiding the Careers of Trainees in Cancer Research.

Klaus Schwartz Commemorative Medal, Awarded by the International
Association of Bioinorganic Scientists for the year of 2006. San Diego,
CA, February 23, 2007.

[Business Address]{.underline}: Chief, Section of the Molecular Biology
of Selenium

Laboratory of Cancer Prevention

Center for Cancer Research

Division of Basic Sciences

National Cancer Institute

National Institutes of Health

Building 37, Room 6032A

Bethesda, MD 20892

Tel: (301) 496-2797

####  Fax: (301) 435-4957

E-mail: [hatfield@dc37a.nci.nih.gov](mailto:hatfield@nig.gov)

**BIBLIOGRAPHY**

***Dolph L. Hatfield, Ph.D.***

1.  Forrest, H.S., Hatfield, D.L. and van Baalen, C.: Characterization
    of a second yellow compound from *Drosophila melanogaster*.
    ***Nature*** **183**: 1269-1270, 1959.

2.  Forrest, H.S., Hatfield, D.L. and Lagowski, J.M.: Uric acid
    riboside. Part I. Isolation and reinvestigation of the structure.
    ***J. Chem. Soc**.* 963-968, 1961.

3.  Hatfield, D.L., van Baalen, C. and Forrest, H.S.: Pteridines in blue
    green algae. ***Plant Physiol.*** **36**: 240-243, 1961.

4.  Hatfield, D.L. and Forrest, H.S.: Biosynthesis of 3-ribosyluric acid
    (uric acid riboside). ***Biochim. Biophys. Acta* 62**: 185-187,
    1962.

5.  Schmid, W. and Hatfield, D.L.: Normal karyotype/translocation
    mosaic. **Cytogenetics 1**: 210-216, 1962.

6.  Hatfield, D.L., Rinehart, R.R. and Forrest, H.S.: 3-Ribosyluric
    acid. Part II. Isolation of the corresponding nucleotide from beef
    blood. ***J. Chem. Soc.*** 899-902, 1963.

7.  Hatfield, D.L., Forrest, H.S. and Wyngaarden, J.B.: Biosynthesis of
    a new xanthine ribonucleotide by beef erythrocytes. ***Biochim.
    Biophys. Acta*** **68:** 322-324, 1963.

8.  Hatfield, D.L. and Wyngaarden, J.B.: 3-Ribosyl purines. Part I.
    Synthe­sis of (3-ribosylxanthine) 5\'-phosphate and (3-ribosyluric
    acid) 5\'-phosphate by a pyrimidine ribonucleotide pyrophosphorylase
    of beef eryth­rocytes. ***J. Biol. Chem.*** **239:** 2580-2586, 1964.

9.  Hatfield, D.L. and Wyngaarden, J.B.: 3-Ribosyl purines. Part II:
    Studies on (3-ribosylxanthine) 5\'-phosphate and on ribonucleotide
    derivatives of certain uracil analogues. ***J. Biol. Chem.***
    **239:** 2587-2592, 1964.

10. Hatfield, D.L., Greenland, R.A., Stewart, H.L. and Wyngaarden, J.B.:
    Biosynthesis of a new uric acid ribonucleotide. ***Biochim. Biophys.
    Acta*** **91:** 163-166, 1964.

11. Zimmerman, M. and Hatfield, D.L.: Biosynthesis of a
    3-N-deoxy-ribosylxan­thine using thymidine phosphorylase. ***Biochim.
    Biophys. Acta*** **91:** 326-328, 1964.

12. Hatfield, D.L.: Oligonucleotide-ribosome-AA-sRNA interactions.
    ***Cold Spring Harbor Symposium on Quant. Biol.*** **31:** 919-922,
    1966.

13. Nirenberg, M., Caskey, T., Marshall, R., Brimacombe, R., Kellogg,
    D., Doctor, B., Hatfield, D.L., Levin, J., Rottman, F., Pestka, S.,
    Wilcox, M. and Anderson, F.: The RNA code and protein synthesis.
    ***Cold Spring Harbor Symposium on Quant. Biol.*** **31:** 11-24,
    1966.

14. Hatfield, D.L., Hofnung, M. and Schwartz, M.: Nonsense mutations in
    the maltose A region in *E. coli*. ***J. Bacteriol.*** **98:**
    559-567, 1969.

15. Hatfield, D.L., Hofnung, M. and Schwartz, M.: Nonsense mutations in
    the maltose A region of the genetic map of *E. coli*. ***J.
    Bacteriol.*** **100:** 1311-1315, 1969.

16. Hatfield, D.L. and Portugal, F.: Seryl-tRNA in mammalian tissues.
    Chro­matographic differences in brain and liver and a specific
    response to the codon, UGA. ***Proc. Natl. Acad. Sci. USA*** **67:**
    1200-1206, 1970.

17. Hatfield, D.L., Portugal, F. and Caicuts, M.: Transfer RNA specif
    icity in mammalian tissues and codon responses of seryl transfer
    RNA. Symposium on Transfer RNA and Transfer RNA Modification in
    Differen­tiation and Neoplasia held at the National Cancer Institute,
    Bethesda, MD Oct. 5-7, 1970, and published in ***Cancer Res.***
    **31:** 697-700, 1971.

18. Hatfield, D.L. and Nirenberg, M.: Binding of radioactive
    oligonucleotides to ribosomes. ***Biochemistry*** **10:** 4318-4323,
    1971.

19. Hofnung, M., Schwartz, M. and Hatfield, D.L.: Complementation in the
    maltose-A region of the *E. coli* K12 genetic map. ***J. Mol.
    Biol.*** **61:** 681-694, 1971.

20. Hatfield, D.L.: Recognition of nonsense codons in mammalian cells.
    ***Proc. Natl. Acad. Sci. USA*** **69:** 3014-3018, 1972.

21. Hofnung, M., Hatfield, D.L. and Schwartz, M.: Mal B region in *E.
    coli* K12. Characterization of new mutations. ***J. Bacteriol.***
    **117:** 40-47, 1974.

22. Silva, R. and Hatfield, D.L.: Orotate phosphoribosyltranferase:
    Orotidy­late decarboxylase (Erythrocyte). ***Methods in Enzymology***
    **51:** 143-154, 1978.

23. Hatfield, D.L. and Rice, M.: Patterns of codon recognition by
    isoacceptor aminoacyl-tRNAs from wheat germ. ***Nuc. Acids Res.***
    **5:** 3491-3502, 1978.

24. Hatfield, D.L., Rice, M. and Hoffman, E.: Patterns of codon
    recognition by isoacceptor aminoacyl-tRNAs from hymenoptera.
    ***Biochem. Biophys. Res. Commun.*** **85:** 436-444, 1978.

25. Hatfield, D.L., Matthews, C. and Rice, M.: Aminoacyl-tRNA
    popula­tions in mammalian ***Cell***s: Chromatographic profiles and
    patterns of codon recognition. ***Biochim. Biophys. Acta*** **564:**
    414-423, 1979.

26. Hatfield, D.L., Richer, L., Lyon, J. and Rice, M.: Relative
    utiliza­tion of mammalian Lys-tRNA isoacceptors in protein synthesis.
    ***FEBS Letters*** **113:** 249-252, 1980.

27. Hatfield, D.L., Rice, M. and Mushinski, J.: Comparison of the codon
    recognition properties and of the utilization of normal and tumor
    specific Phe-tRNAs in protein synthesis. ***Cancer Lett.*** **12:**
    251-258, 1981.

28. Wilson, M., Hatfield, D.L. and Poirier, L.: Aminoacylation of
    ethionine to rat liver tRNAMet and its incorporation into protein.
    ***FEBS Letters*** **128:** 157-160, 1981.

29. Smith, D.W.E., McNamara, A., Rice, M. and Hatfield, D.L.: The
    effects of a post-transcriptional modification on the function of
    tRNALys isoaccepting species in translation. ***J. Biol. Chem.***
    **256:** 10033-10036, 1981.

30. Diamond, A., Dudock, B. and Hatfield, D.L.: Structure and properties
    of a bovine liver UGA suppressor serine tRNA with a tryptophan
    anticodon. ***Cell*** **25:** 497-506, 1981.

31. Hatfield, D.L., Varricchio, F., Rice, M. and Forget, B.: The
    amino-acyl-tRNA population of human reticulocytes. ***J. Biol.
    Chem.*** **257:** 3183-3188, 1982.

32. Hatfield, D.L., Rice, M., Hession, C. and Melera, P.:
    Aminoacyl-tRNAs from *Physarum polycephalum*: Patterns of codon
    recognition. ***J. Bacteriol.*** **151:** 1013-1021, 1982.

33. Hatfield, D.L., Diamond, A. and Dudock, B.: Opal suppressor serine
    tRNAs from bovine liver form phosphosery1-tRNA. ***Proc. Natl. Acad.
    Sci. USA*** **79:** 6215-6219, 1982.

34. Hatfield, D.L., Dudock, B. and Eden, F.: Characterization and
    nucleotide sequence of a chicken gene encoding an opal suppressor
    tRNA and its flanking DNA segments. ***Proc. Natl. Acad. Sci. USA*
    80:** 4940-4944, 1983.

35. Wilson, M.J. and Hatfield, D.L.: Incorporation of modified amino
    acids into protein *in vivo*. ***Biochim. Biophys. Acta*** **781:**
    205-215, 1984.

36. Smith, D.W.E., McNamara, A., Mushinski, J. and Hatfield, D.L.:
    Tumor-specific, hypomodified phenylalanyl-tRNA is utilized in
    translation in preference to the fully modified isoacceptor of
    normal cells. ***J. Biol. Chem.*** **260:** 147-151, 1985.

37. O\'Neill, V., Eden, F., Pratt, K. and Hatfield, D.L.: A human
    suppressor tRNA gene and pseudogene. ***J. Biol. Chem.*** **260:**
    2501-2508, 1985.

38. Green, M.R., Hatfield, D.L., Miller, M.J. and Peacock, A.C.:
    Prolactin homogeneously induces the tRNA population of mouse mammary
    explants. ***Biochem. Biophys. Res. Commun.*** **129:** 233-239,
    1985.

39. Hatfield, D.L.: Suppression of termination codons in higher
    eukaryotes. ***Trends Biochem. Sci.*** **10:** 201-204, 1985.

40. Pratt, K., Eden, F.C., You, K., O\'Neill, V. and Hatfield, D.L.:
    Con­served sequences in both coding and 5\' flanking regions of
    mammalian opal suppressor tRNA genes. ***Nuc. Acids Res.*** **13:**
    4765-4775, 1985.

41. Smith, D.W.E. and Hatfield, D.L.: Effects of post-transcriptional
    base modifications on the site-specific function of transfer RNA in
    eukaryotic translation. ***J. Mol. Biol.*** **189:** 663-671, 1986.

42. Hatfield, D. and Rice, M.: Aminoacyl-tRNA (anticodon): codon
    adaptation in human and rabbit reticulocytes. ***Biochem.
    Internatl.* 13:** 835-842, 1986.

43. McBride, O.W., Rajagopalan, M., and Hatfield, D.L.: Opal suppressor
    phosphoserine tRNA gene and pseudogene are located on human
    chromosomes 19 and 22, respectively. ***J. Biol. Chem.*** **262:**
    11163-11166, 1987.

44. Lee, B.J., de la Pena, P., Tobian, J.A., Zasloff, M. and Hatfield,
    D.L.: Unique pathway of expression of an opal suppressor
    phospho­serine tRNA. ***Proc. Natl. Acad. Sci. USA*** **84:**
    6384-6388, 1987.

45. Hatfield, D., Thorgeirsson, S.S., Copeland, T.D., Oroszlan, S., and
    Bustin, M.: Immunopurification of the suppressor tRNA dependent
    rabbit -globin readthrough protein. ***Biochemistry*** **27:**
    1179-1183, 1988.

46. McBride, O.W., Mitchell, A., Lee, B.J., Mullenbach, G. and Hatfield,
    D.L.: Glutathione peroxidase gene maps to human chromosomes 3, 21,
    and X. ***BioFactors*** **1:** 285-292, 1988.

47. Feng, Y-X., Hatfield, D.L., Rein, A. and Levin, J.G.: Translational
    readthrough of the murine leukemia virus *gag* gene amber codon does
    not require virus-induced alteration of tRNA. ***J. Virol.***
    **63:** 2405-2410, 1989.

48. Feng, Y-X, Levin, J.G., Hatfield, D.L., Schaefer, T.S., Gorelick,
    R.J. and Rein, A.: Suppression of UAA and UGA termination codons in
    mutant murine leukemia viruses. ***J. Virol.*** **63:** 2870-2873,
    1989.

49. Lee, B.J., Kang, S.K. and Hatfield, D.: Transcription of Xenopus
    seleno­cysteine tRNA^Ser^ (formerly designated opal suppressor
    phosphoserine tRNA) is directed by multiple 5\' extragenic
    regulatory elements. ***J. Biol. Chem.*** **264:** 9696-9702, 1989.

50. Lee, B.J., Worland, P.J., Davis, J. N., Stadtman, T.C. and Hatfield,
    D.L.: Identification of a selenocysteyl-tRNASer in mammalian cells
    which recognizes the nonsense codon, UGA. ***J. Biol. Chem.***
    **264:** 9724-9727, 1989.

51. Hatfield, D.L., Lee, B.J., Feng, Y-X., Levin, J.G., Rein, A.,
    Oroszlan, S.: Mechanisms of ribosomal frameshifting for synthesis of
    the protease in HIV and other retroviruses and the possible use of
    hypomodified tRNAs in the frameshift event. In **Proteases of
    Retroviruses**. Ed. by Kostka, V., Walter De Gruyter & Co., New
    York, pp. 25-34, 1989.

52. Hatfield, D., Feng, Y-X., Lee, B.J., Rein, A., Levin, J. and
    Oroszlan, S.: Chromatographic analysis of aminoacyl-tRNAs which are
    required for translation of codons at and around the ribosomal
    frameshift sites of HTLV-1 and BLV. ***Virology*** **173:** 736-742,
    1989.

53. Hatfield, D., Smith, D.W.E., Lee, B.J., Worland, P.J. and Oroszlan,
    S.: Structure and function of suppressor tRNAs in higher eukaryotes.
    ***CRC Crit. Rev. Biochem.*** **25:** 71-96, 1990. **(Figure
    associated with this article appeared on the cover of the same
    journal.)**

54. Lee, B.J., Rajagopalan, M., Kim, Y.S., You, K.H., Jacobson, K.B. and
    Hatfield, D.: Selenocysteine tRNA\[^Ser\]Sec^ gene is ubiquitous
    within the animal kingdom. ***Mol. Cell. Biol.* 10:** 1940-1949,
    1990.

55. Hatfield, D. and Oroszlan, S.: The *where*, *what,* and *how* of
    ribosomal frame­shifting in retroviral protein synthesis. ***Trends
    Biochem. Sci.*** **15:** 186-190, 1990.

56. Hatfield, D.L., Lee, B.J., Smith, D.W.E. and Oroszlan, S.: Role of
    nonsense, frameshift and missense suppressor tRNAs in mammalian
    cells. In ***Prog. Mol. Subcell. Biol.*** Ed. by Muller, W. E. G.,
    Vol. 11, Berlin, Heidel­berg, New York, Tokyo, Springer-Verlag, pp.
    115-146, 1990.

57. Feng, Y-X., Levin, J.G., Hatfield, D., Schaefer, T.S., Gorelik, R.J.
    and Rein, A.: Studies on readthrough suppression in Moloney MuLV. In
    ***New Aspects of Positive Strand RNA Viruses.*** Ed. by M. Brinton
    and F. X. Heinz, Am. Soc. Microbiol., Washington, DC, pp. 188-191,
    1990.

58. Diamond, A.M., Montero-Puerner, Y., Lee, B.J. and Hatfield, D.:
    Selenocys­teine inserting tRNAs are likely generated by tRNA editing.
    ***Nucl. Acids Res.* 18:** 6727, 1990.

59. Lee, B.J., Choi, I.S., Kang, S.G., Kim, Y.S., Rajagopalan, M., You,
    K.H. and Hatfield, D.: Selenocysteine, the 21st naturally occurring
    amino acid within the universal genetic code. ***Recent Prog. Mol.
    Biol. Genet. Engin. in Korea*** **5:** 3-16, 1990.

60. Hatfield, D.L., Lee, B.J., Hampton, L. and Diamond, A.M.: Selenium
    induces changes in the selenocysteine tRNA^\[Ser\]Sec^ population in
    mammalian cells. ***Nucl. Acids Res.*** **19:** 939-943, 1991.

61. Hatfield, D.L., Lee, B.J., Price, N.M. and Stadtman, T.C.:
    Selenocysteyl tRNA occurs in the diatom*, Thalassiosira*, and in the
    ciliate, *Tetrahymena*. ***Mol. Microbiol**.* **5:** 1183-1186,
    1991.

62. Sobol, R.W., Suhadolnik, R.J., Kumar, A., Lee, B.J., Hatfield, D.L.
    and Wilson, S.H.: Localization of a polynucleotide binding region in
    the HIV-1 reverse transcriptase: Implications for primer binding.
    ***Biochemistry*** **30:** 10623-10631, 1991.

63. Lee, B.J., Choi, I.S., Kang, S.G., Kim, Y.S., You, K.Y. and
    Hatfield, D.: Structure, function and expression of selenocysteine
    tRNA^\[Ser\]Sec^ gene. ***Recent Prog. Mol. Biol. Genet. Engin.***
    **6:** 97-101, 1991.

64. Hatfield, D.L., Levin, J.G., Rein, A. and Oroszlan, S.:
    Translational suppression in retroviral gene expression. Ed. by K.
    Maramrosch, F. A. Murphy and A. J. Shatkin, Academic Press, Inc.,
    Orlando, FL, ***Adv. Virus Res.* 41:** 193-239, 1992.

65. Hatfield, D., Choi, I.S., Mischke, S. and Owens, L.D.:
    Selenocysteyl-tRNAs recognize UGA in *Beta vulgaris*, a higher
    plant, and in *Gliocladium virens*, a filamentous fungi. ***Biochem.
    Biophys. Res. Comm.*** **184:** 254-259, 1992.

66. Hatfield, D., Lee, B. and Pirtle, R. (Editors): ***Transfer RNA in
    Protein Synthesis***. CRC Press, Inc., Boca Raton, FL. 436 pp, 1992.

67. Hatfield, D., Jung, J-E., Lee, B.J. and Choi, I.S.: Aminoacyl-tRNA
    (anticodon):codon adaptation in higher eukaryotes. Chapter 4 in
    ***Transfer RNA in Protein Synthesis***, Ed. by D. Hatfield, B.J.
    Lee and R. M. Pirtle, CRC Press, Inc., Boca Raton, FL. pp 113-123,
    1992.

68. Hatfield, D., Choi, I.S., Lee, B.J. and Jung, J-E.: Selenocysteine,
    a new addition to the universal genetic code. Chapter 9 in
    ***Transfer RNA in Protein Synthesis***, Ed. by D. Hatfield, B.J.
    Lee and R.M. Pirtle, CRC Press, Inc., Boca Raton, FL. pp 269-278,
    1992.

69. Mitchell, A., Bale, A.E., Lee, B.J., Hatfield, D., Harley, H.,
    Rudle, S., Fan, Y.S., Fukushima, Y., Shows, T.B. and McBride, O.W.:
    Regional localization of the selenocysteine tRNA gene (TRSP) on
    human chromosome 19. ***Cytogenet. Cell Genet.*** **61:** 117-120,
    1992.

70. Diamond, A., Cruz, R., Bencsics, C. and Hatfield, D.: A pseudogene
    for human glutathione peroxidase. ***Gene*** **122:** 377-380, 1992.

71. Hatfield, D. and Diamond, A.: UGA: A split personality in the
    universal genetic code. ***Trends in Genetics*** **9:** 69-70, 1993.

72. Levin, J.G., Hatfield, D.L., Oroszlan, S. and Rein, A.: Biosynthesis
    of reverse transcriptase. In: ***Reverse Transcriptase***, Ed. by S.
    Goff and A.M. Skalka, Cold Spring Harbor Laboratory Press, Cold
    Spring Harbor, New York pp. 5-31, 1993.

73. Diamond, A.M., Choi, I.S., Crain, P.F., Hashizume, T., Pomerantz,
    S., Cruz, R., Steer, C., Hill, K., Burk, R., McCloskey, J.A. and
    Hatfield, D.: Dietary selenium affects methylation of the wobble
    nucleoside in the anticodon of selenocysteine tRNA^\[Ser\]Sec^.
    ***J. Biol. Chem.*** **268:** 14215-14223, 1993.

74. Kumar, A., Kim, H-R., Sobol, R.W., Becerra, P., Lee, B.J., Hatfield,
    D., Suhadolnik, J. and Wilson, S.H.: Mapping of nucleic acid binding
    in proteolytic domains of HIV-1 reverse transcriptase.
    ***Biochemistry*** **32:** 7466-7474, 1993.

75. Hatfield, D., Choi, I.S., Ohama, T., Jung, J-E., and Diamond, A.:
    Selenocysteine tRNA^\[Ser\]Sec^ isoacceptors as central components
    in selenoprotein biosynthesis in eukaryotes. Chapter 2 in
    ***Selenium in Biology and Human Health***. Ed. by R.F. Burk.
    Berlin, Heidelberg, New York, Tokyo, Springer-Verlag, pp 25-44,
    1994.

76. Choi, I.S., Diamond, A.M., Crain, P.F., Kolker, J., McCloskey, J.A.
    and Hatfield, D.: Reconstitution of the biosynthetic pathway of
    selenocyst­eine tRNAs in *Xenopus* oocytes. ***Biochemistry***
    **33:** 601-605, 1994.

77. Ohama, T., Choi, I.S., Hatfield, D. and Johnson, K.: Mouse
    selenocysteine tRNA^\[Ser\]Sec^ gene (TRSP) and its localization on
    chromosome 7. ***Genomics*** **19:** 595-596, 1994.

78. Berry, M.J., Harney, J.W., Ohama, T. and Hatfield, D.:
    Selenocysteine insertion or termination: factors affecting UGA codon
    fate and complementary anticodon:codon mutations. ***Nucleic Acids
    Res.*** **22:** 3753-3759, 1994.

79. Jung, J-E., Karoor, V., Sandbaken, M., Lee, B.J., Ohama, T.,
    Gesteland, R.F., Atkins, J.F., Mullenbach, G., Hill, K.E., Wahba, A.
    and Hatfield, D.: Utilization of selenocysteyl-tRNA^\[Ser\]Sec^ and
    seryl-tRNA^\[Ser\]Sec^ in protein synthesis. ***J. Biol. Chem.***
    **269:** 29739-29745, 1994.

80. Ohama, T., Yang, D. and Hatfield, D.: Selenocysteine tRNA and serine
    tRNA are aminoacylated by the same synthetase, but may manifest
    different identities with respect to the long extra arm. ***Arch.
    Biochem. Biophys.*** **315:** 293-301, 1994.

81. Ohama, T., Jung, J-E., Park, S.I., Clouse, K.A., Lee, B.J. and
    Hatfield, D.: Identification of new selenocyst­eine tRNA^\[Ser\]Sec^
    isoacceptors in human cell lines. ***Biochem. Mol. Biol.
    Internatl.*** **36:** 421-427, 1995.

82. Park, J.M., Choi, I.S., Kang, S.G., Lee, J.Y., Hatfield, D.L. and
    Lee, B.J.: Upstream promoter elements are sufficient for
    selenocysteine tRNA^\[Ser\]Sec^ gene transcription and determine the
    transcription start site. ***Gene*** **162:** 13-19, 1995.

83. Park, J.M., Yang, E.S., Hatfield, D.L. and Lee, B.J.: Analysis of
    the selenocysteine tRNA^\[Ser\]Sec^ gene transcription *in vitro*
    using *Xenopus* oocyte extracts. ***Biochem. Biophys. Res.
    Commun.*** **226:** 231-236, 1996.

84. Diamond, A.M., Jaffe, D., Murray, J., Safa, A., Samuels, B.L. and
    Hatfield, D.: Effects of lovastatin on human breast carcinoma cells.
    Differential toxicity on an adriamycin-resistant derivative and
    influence on selenocysteine tRNAs. ***Biochem. Mol. Biol.
    Internatl.*** **38:** 345-355, 1996.

85. Lee, B.J., Park, S.I., Park, J.M. Chittum, H.S. and Hatfield, D.L.:
    Molecular biology of selenium and its role in human health.
    ***Molecules and Cells*** **6:** 509-520, 1996.

86. Park, J.M., Hatfield, D.L. and Lee, B.J.: Cross-competition for
    TATA-binding protein between TATA boxes of the selenocysteine
    tRNA^\[Ser\]Sec^ promoter and RNA polymerase II promoters.
    ***Molecules and Cells*** **7:** 72-77, 1997.

87. Chittum, H.S., Baek, H.J., Diamond, A.M., Fernandez-Salguero, P.,
    Gonzalez, F., Ohama, T., Hatfield, D.L., Kuehn, M. and Lee, B.J.:
    Selenocysteine tRNA levels and selenium-dependent glutathione
    peroxidase activity in mouse embryonic stem cells heterozygous for a
    targeted mutation in the Sec tRNA^\[Ser\]Sec^ gene.
    ***Biochemistry*** **36:** 8634-8639, 1997.

88. Hori, K., Hatfield, D., Maldarlee, F., Lee, B.J. and Clouse, K.A.:
    Selenium supplementation suppresses TNF--induced human
    immunodeficiency virus type 1 replication *in vitro*. ***Aids Res.
    Human Retroviruses*** **13:** 1325-1332, 1997.

89. Park, S.I., Park, J.M., Chittum, H.S., Yang, E.S., Carlson, B.A.,
    Lee, B.J. and Hatfield, D.L.: Selenocysteine tRNAs as central
    components of selenoprotein biosynthesis in eukaryotes. ***Biomed.
    Environ. Sci.*** **10:** 116-124, 1997.

90. Baek, H.J., Chittum, H.S., Yang, E.S., Park, S.I., Park, J.M.,
    Gladyshev, V.N., Moustafa, M.E., Carlson, B.A., Diamond, A.M., Lee,
    B.J. and Hatfield, D.L.: Response of the selenocysteine tRNA
    population to selenium in mammals and *Xenopus* oocytes. ***Nuc.
    Acids Res. Symp. Ser.* 36:** 157-158, 1997.

91. Park, J.M., Lee, J.Y., Hatfield, D.L. and Lee, B.J.: Differential
    mode of TBP utilization in transcription of the tRNA^\[Ser\]Sec^
    gene and TATA-less class III genes. ***Gene*** **196:** 99-103,
    1997.

92. Chittum, H.S., Carlson, B.A., Hill, K.E., Burk, R.F., Lee, B.J. and
    Hatfield, D.L.: Replenishment of selenium deficient rats with
    selenium results in redistribution of the selenocysteine tRNA
    population in a tissue specific manner. ***Biochim. Biophys. Acta***
    **1359:** 25-34, 1997.

93. Gladyshev, V.N., Jeang, K-T., Wootton, J.C. and Hatfield, D.: A new
    human selenium-containing protein: purification, characterization
    and cDNA sequence. ***J. Biol. Chem.*** **273:** 8910-8915, 1998.

94. Chittum, H.S., Lane, W.S., Carlson, B.A., Roller, P.P., Lung, F-D.,
    Lee, B.J. and Hatfield, D.L.: Rabbit -globin is extended beyond its
    UGA stop codon by multiple suppressions and translational reading
    gaps. ***Biochemistry*** **37:** 10866-10870, 1998.

95. Gladyshev, V.N., Factor, V.M., Housseau, F. and Hatfield, D.L.:
    Contrasting patterns of regulation of the antioxidant
    selenoproteins, thioredoxin reductase and glutathione peroxidase, in
    cancer cells. ***Biochem. Biophys. Res. Comm.*** **251:** 488-493,
    1998.

96. Moustafa, M.E., El-Saadani, M.A., Kandeel, K.M., Mansur, D.B., Lee,
    B.J., Hatfield, D.L. and Diamond, A.M.: Over-production of
    selenocysteine tRNA^\[Ser\]Sec^ in Chinese hamster ovary cells
    following transfection of the mouse tRNA^\[Ser\]Sec^ gene. ***RNA***
    **4:** 1436-1443, 1998.

97. Hatfield, D., Gladyshev, V., Park, J.M., Park, S.I., Chittum, H.S.,
    Huh, J.R., Carlson, B.A., Kim, M., Moustafa, M.E. and Lee, B.J.:
    Biosynthesis of selenocysteine and its incorporation into protein as
    the 21st amino acid. Chapter 14 in ***Comprehensive Natural Products
    Chemistry*** Ed. J.F. Kelly, Elsevier Sc. Ltd. 4**:** 353-380, 1999.

98. Carlson, B.A., Kwon, S., Chamorro, M., Oroszlan, S., Hatfield, D.L.
    and Lee, B.J.: Transfer RNA modification status influences
    retroviral ribosomal frameshifting. ***Virology*** **255:** 2-8,
    1999.

99. Huh, J.R., Park, J.M., Kim. M., Carlson, B.A., Hatfield, D.L. and
    Lee, B.J.: Recruitment of TBP or TFIIB to a promoter proximal
    position leads to stimulation of RNA polymerase II transcription
    without activator proteins both *in vivo* and *in vitro*.
    ***Biochem. Biophys. Res. Comm.*** **256:** 45-51, 1999.

100. Gladyshev, V.N., Stadtman, T., Hatfield, D.L. and Jeang, K-T.:
     Levels of major selenoproteins in T cells decrease during HIV
     infection and low molecular mass selenium compounds increase.
     ***Proc. Natl. Acad. Sci. USA*** **96:** 835-839, 1999.

101. Gladyshev, V.N. and Hatfield, D.L.: Selenocysteine-Containing
     Proteins in Mammals. ***J. Biomed. Science*** **6:** 151-160, 1999.

102. Zhou, X., Park, S., Moustafa, M.E., Carlson, B.A., Crain, P.F.,
     Diamond, A., Hatfield, D.L. and Lee, B.J.: Selenium metabolism in
     *Drosophila*: Characterization of the selenocysteine tRNA
     population. ***J. Biol. Chem.*** **274:** 18729-18734, 1999.

103. Gladyshev, V.N., Krause, M., Xu, X-M., Korotkov, K., Kryukov, G.V.,
     Sun, Q-A., Lee, B.J., Wootton, J.C. and Hatfield, D.L.:
     Selenocysteine-containing thioredoxin reductase in *C. elegans*.
     ***Biochem.*** ***Biophys. Res. Comm.*** **259:** 244-249, 1999.

104. Xu, S-M., Zhou, X., Carlson, B.A., Kim, L.K., Huh, T-L., Lee, B.J.
     and Hatfield, D.L.: Zebrafish genome contains two distinct
     selenocysteine (Sec) tRNA^\[Ser\]Sec^ genes. ***FEBS Lett.* 454:**
     16-20, 1999.

105. Harris, L.F., Sullivan, M.R. and Hatfield, D.L.: Directed Molecular
     Evolution. ***Origins of Life and Evolution of the Biosphere***
     **29:** 425-435, 1999. Also published on the internet in the
     ***University of Minnesota Supercomputing Institute Research
     Report*** UMSI 98/201 November, 1998.

106. Sun, Q-A., Wu, Y., Zappacosta, F., Jeang, K.T., Lee, B.J.,
     Hatfield, D. and Gladyshev, V.: Redox regulation of cell signaling
     by selenocysteine in mammalian thioredoxin reductases. ***J. Biol.
     Chem.*** **274:** 24522-24530, 1999.

107. Xu, X-M., Carlson, B.A., Kim, L.K., Lee, B.J., Hatfield, D.L., and
     Diamond, A.M.: Analysis of selenocysteine (Sec) tRNA^\[Ser\]Sec^ in
     Chinese hamsters. ***Gene*** **239:** 49-53, 1999.

108. Kumaraswamy, E., Xu, X-M., Martin-Romero, F.J., Carlson, B.A. and
     Hatfield, D.L.: Roles of UGA in mammalian protein synthesis:
     Selenocysteine, stop, suppression and reading gaps. ***Current
     Topics in Biochem. Res.*** **1:** 113-123, 1999.

109. Gladyshev, V.N., Martin-Romero, F.J., Xu, X-M., Kumaraswamy, E.,
     Carlson, B.A., Hatfield, D. and Lee, B.J.: Molecular biology of
     selenium and its role in cancer, AIDS and other human diseases.
     ***Recent Res. Dev. in Biochem.*** **1:** 145-167, 1999.

110. Copeland, P.R., Fletcher, J.E., Carlson, B.A., Hatfield, D.L. and
     Driscoll, D.M.: Identification of a novel, mammalian RNA binding
     protein required for the cotranslational incorporation of
     selenocysteine. ***EMBO J.*** **19:** 306-314, 2000.

111. Carlson, B.A., Kwon, S.Y., Lee, B.J. and Hatfield, D.L.: Yeast
     asparagine (Asn) tRNA without Q base promotes eukaryotic
     frameshifting more efficiently than mammalian Asn tRNA with or
     without Q base. ***Mol. Cells*** **10:** 113-118, 2000.

112. Gladyshev, V.N. and Hatfield, D.L.: Analysis of
     selenocysteine-containing proteins. In ***Current Protocols in
     Protein Science***, John Wiley and Sons, Inc. New York, New York,
     USA, **1:** 3.8.1-3.8.18 2000.

113. Mansur, D.B., Hao, H., Gladyshev, V.N., Korotkov, K., Hu, Y.,
     Moustafa, M.E., El-Saadani, M.A., Carlson, B.A., Hatfield, D.L. and
     Diamond, A.M.: Multiple levels of regulation of selenoprotein
     biosynthesis revealed from the analysis of human glioma cell lines.
     ***Biochem. Pharmacol.*** **60:** 489-497, 2000.

114. Tujebajeva, R.M., Copeland, P.R., Xu, X-M., Carlson, B.A., Harney,
     J.W., Driscoll, D.M., Hatfield, D.L. and Berry, M.J.: Decoding
     apparatus for eukaryotic selenocysteine insertion. ***EMBO
     Reports*** **1:** 158-163, 2000.

115. Warner, G.J., Berry. M.J., Moustafa, M.E., Carlson, B.A., Hatfield,
     D.L. and Faust, J.R.: Inhibition of selenoprotein synthesis by
     selenocysteine tRNA^\[Ser\]Sec^ lacking isopentenyladenosine. ***J.
     Biol. Chem.*** **275:** 28110-28119, 2000.

116. Kim, L.K., Matsufuji, T., Matsufuji, S., Carlson, B.A., Kim, S.S.,
     Hatfield, D.L. and Lee, B.J.: Methylation of the ribosyl moiety at
     position 34 of selenocysteine tRNA^\[Ser\]Sec^ is governed by both
     primary and tertiary structure. ***RNA*** **6:** 1306-1315, 2000.

117. Kumaraswany, E., Malykh, A., Korotkov, K., Kozyavkin, S., Hu, Y.,
     Kwon, S.Y., Moustafa, M.E., Carlson, B.A., Berry, M.J., Lee, B.J.,
     Hatfield, D.L., Diamond, and Gladyshev, V.: Structure-expression
     relationship of the 15 kDa selenoprotein gene: Possible role of the
     protein in cancer etiology. ***J. Biol. Chem.*** **275:**
     35540-35547, 2000.

118. Sun, Q-A., Zappacosta, F., Factor, V., Wirth, P. Hatfield, D.L. and
     Gladyshev, V.N.: Heterogeneity within animal thioredoxin
     reductases: Evidence for alternative first exon splicing. ***J.
     Biol. Chem.*** **276:** 3106-3114, 2001.

119. Carlson, B.A., Mushinski, J.F., Henderson, D.W., Kwon, S.Y., Crain,
     P.F., Lee, B.J. and Hatfield, D.L.: 1-Methylguanosine in place of Y
     base at position 37 in phenylalanine tRNA is responsible for its
     shiftiness in retroviral ribosomal frameshifting. ***Virology***
     **279:** 130-135, 2001.

120. Hatfield, D.L. (Editor): ***Selenium*: *Its molecular biology and
     role in human health.*** Kluwer Academic Publishers, Norwell, MA,
     pp. 326, 2001.

121. Hatfield, D.L.: Preface. In Selenium**: *Its molecular biology and
     role in human health.*** D.L. Hatfield, Editor, p. xvii-xviii,
     Kluwer Academic Publishers, Norwell, MA, pp. 326, 2001.

122. Hatfield, D.L.: ***Introduction. In Selenium*: *Its molecular
     biology and role in human health.*** D.L. Hatfield, Editor. Chapter
     1, p. 1-4, Kluwer Academic Publishers, Norwell, MA, pp. 326, 2001.

123. Carlson, B.A., Martin-Romero, F.J., Kumaraswamy, E., Moustafa,
     M.E., Zhi, H., Hatfield, D.L and Lee, B.J.: Mammalian
     selenocysteine tRNA. In ***Selenium*: *Its molecular biology and
     role in human health.*** D.L. Hatfield, Editor. Chapter 3, p.
     23-32, Kluwer Academic Publishers, Norwell, MA, pp. 326, 2001.

124. Gladyshev, V.N., Diamond, A.M. and Hatfield, D.L.: The 15 kDa
     selenoprotein (Sep15): Functional studies and a role in cancer
     etiology. In ***Selenium*: *Its molecular biology and role in human
     health.*** D.L. Hatfield, Editor. Chapter 13, p. 147-155, Kluwer
     Academic Publishers, Norwell, MA, pp. 326, 2001.

125. Hu, Y.J., Konstantin, V., Korotkov, K.V., Mehta, R., Hatfield,
     D.L., Rotimi, C., Luke, A., Prewitt T.E., Cooper, R.S., Stock, W.,
     Vokes, E.E., Dolan, M.E., Gladyshev, V.N. and Diamond, A.M.: Ethnic
     distribution and functional consequences of nucleotide polymorphism
     in the 3'-untranslated region of the human 15 kDa selenoprotein
     gene. ***Cancer Res.*** **61:** 2307-2310, 2001.

126. Moustafa, M.E., Carlson, B.A., El-Saadani, M.A., Kryukov, G.V.,
     Sun, Q-A., Harney, J.W., Hill, K.E., Combs, G.F., Feigenbaum, L.,
     Mansur, D.B., Burk, R.F., Berry, M. J., Diamond, A.M., Lee, B.J.,
     Gladyshev, V.N. and Hatfield, D.L.: Selective inhibition of
     selenocysteine tRNA maturation and selenoprotein synthesis in
     transgenic mice expressing isopentenyladenosine-deficient
     selenocysteine tRNA^\[Ser\]Sec^. ***Mol. Cell. Biol.*** **21:**
     3840-3852, 2001. **(Cover figure associated with this article
     appeared on the July, 2001 Cover \[Issue 13\])**

127. Korotkov, D.V., Kumaraswamy, E., Zhou, Y., Hatfield, D.L. and
     Gladyshev, V.N.: Association between the 15 kDa selenoprotein and
     UDP-glucose: glycoprotein glucosyltransferease in the endoplasmic
     reticulum of mammalian cells. ***J. Biol. Chem.*** **276:**
     15330-15336, 2001.

128. Martin-Romero, F.J., Kryukov, G.V., Lobanov, A.V., Lee, B.J.,
     Gladyshev, V.N. and Hatfield, D.L.: Selenium metabolism in
     *Drosophila*: Selenoproteins, seleno-protein mRNA expression and
     mortality. ***J. Biol. Chem.*** **276:** 29798-29804, 2001.

129. Berry, M.J., Tujebajeva, R.M., Copeland, P.R., Xu, X-M., Carlson,
     B.A., Martin, III, G.W., Low, S.C., Mansell, J.B.,
     Grundner-Culmann, E., Harney, J.W., Driscoll, D.M. and Hatfield,
     D.L.: Selenocysteine incorporation directed from the 3'-UTR:
     Characterization of eukaryotic EFsec and mechanistic implications.
     ***BioFactors*** **14:** 17-24, 2001.

130. Korotkov, K.V., Novoselov, S.V., Hatfield, D.L. and Gladyshev,
     V.N.: Mammalian selenoprotein in which selenocysteine (Sec)
     incorporation is supported by a new form of Sec insertion sequence
     element. ***Mol. Cell. Biol.*** **22:** 1402-1411, 2002.

131. Carlson, B.A. and Hatfield, D.L.: Transfer RNAs that insert
     selenocysteine. ***Methods Enzymol.*** **347:** 29-34, 2002.

132. Kumaraswamy, E., Korotkov, K.V., Diamond, A.M., Gladyshev, V.N. and
     Hatfield, D.L.: Genetic and functional analysis of the mammalian
     sep15 selenoprotein. ***Methods Enzymol.* 347:** 188-198, 2002.

133. Hatfield, D.L. and Gladyshev, V.N.: How selenium has altered our
     understanding of the genetic code. ***Mol. Cell. Biol.* 22:**
     3565-3576, 2002.

134. Novoselov, S.V., Rao, M., Onoshko, N.V., Zhi, H., Kryukov, G.V.,
     Xiang, Y., Weeks, D.P., Hatfield, D.L. and Gladyshev, V.N.:
     Selenoproteins and selenocysteine insertion system in the model
     plant cell system, *chlamydomonas reinhardtii*. ***EMBO J.***
     **21:** 3681-3693, 2002.

135. Jameson, R.R., Carlson, B.A., Butz, M., Esser, K., Hatfield, D.L.
     and Diamond, A.M.: Selenium influences the turnover of
     selenocysteine tRNA^\[Ser\]Sec^ in Chinese Hamster ovary cells.
     ***J Nutri.* 132:** 1830-1835, 2002. **(Featured on the journal's
     cover for selected reading.)**

136. Xu, X-M., Carlson, B.A., Grimm, T., Kutza, J., Berry, M.J.,
     Arreola, R., Fields, K., Shanmugam, I., Jeang, K.T., Oroszlan, S.,
     Combs, G., Marx, P.A., Gladyshev, V.N., Clouse, K.A. and Hatfield,
     D.: *Rhesus* monkey simian immunodeficiency virus as a model for
     assessing the role of selenium in AIDS. ***JAIDS*** **31:**
     453-463, 2002.

137. Kumaraswamy, E., Carlson, B.A., Morgan, F., Miyoshi, K., Robinson,
     G., Su, D., Wang, S., Southon, E., Tessarollo, L., Lee, B.J.,
     Gladyshev, V.N., Hennighausen, L. and Hatfield, D.L.: Selective
     removal of the selenocysteine tRNA^\[Ser\]Sec^ gene *(Trsp)* in
     mouse mammary epithelium. ***Mol. Cell. Biol.*** **23:** 1477-1488,
     2003.

138. Hatfield, D.: Selenium and health: Is selenium a magic bullet?
     ***CCR Frontiers in Science*** **2:** 3-4, 2003.

139. Kim, M., Park, C.H., Lee, M.S., Carlson, B.A., Hatfield, D.L. and
     Lee, B.J.: A novel TBP interacting zinc finger protein represses
     transcription by inhibiting the recruitment of TFIIA and TFIIB.
     ***Biochem. Biophys. Res. Comm.*** **306:** 231-238, 2003.

140. Kim, M., Choi, J., Carlson, B.A., Han, J-K., Rhee, K., Sargent, T.,
     Hatfield, D.L. and Lee, B.J.: A novel TBP-Interacting zinc finger
     protein functions in neural development of *Xenopus laevis*.
     ***Biochem. Biophys. Res. Comm.*** **306:** 1106-1111, 2003.

141. Moustafa, M.E., Kumaraswamy, E., Zhong, N., Rao, M., Carlson, B.A.
     and Hatfield, D.L.: Models for assessing the role of selenoproteins
     in health. ***J. Nutrition* 133:** 2494S-2496S, 2003.

142. Rao, M., Carlson, B.A., Novoselov, S.V., Weeks, D.P., Gladyshev,
     V.N. and Hatfield, D.L.: *Chlamydomonas reinhardtii* selenocysteine
     tRNA^\[Ser\]Sec^. ***RNA*** **9:** 923-930, 2003.

143. Hornberger, T.A., McLoughlin, T.J., Leszczynske, J.K., Armstrong,
     D.D., Jameson, R.R., Bowen, P.E., Hwang, E.S., Hou, H., Moustafa,
     M.E., Carlson, B.A., Hatfield, D.L., Diamond, A.M. and Esser, K.A.:
     Selenoprotein-deficient transgenic mice exhibit enhanced
     exercise-induced muscle growth. ***J. Nutrition*** **133:**
     3091-3097, 2003.

144. Kwon, S.Y. Badenhorst, P., Martin-Romero, F.J., Carlson, B.A.,
     Paterson, B.M., Gladyshev, V.N., Lee, B.J. and Hatfield, D.L.: The
     *Drosophila* selenoprotein BthD is required for survival and has a
     role in salivary gland development. ***Mol. Cell. Biol.*** **23:**
     8495-8504, 2003.

145. Carlson, B.A., Novoselov, S.V., Kumaraswamy, E., Lee, B.J., Anver,
     M.R., Gladyshev, V.N. and Hatfield, D.L.: Specific excision of the
     selenocysteine tRNA^\[Ser\]Sec^ gene in mouse liver demonstrates an
     essential role of selenoproteins in liver function. ***J. Biol.
     Chem.* 279:** 8011-8017, 2004.

146. Gladyshev, V.N., Kryukov, G.V., Fomenko, D.E. and Hatfield, D.L.:
     Identification of micronutrient-associated proteins in genomic
     databases. ***Annu. Rev. Nutri.*** **24:** 579-596, 2004.

147. Jin, J.S., Baek, S., Lee, H., Oh. M.Y., Koo, Y.E., Shim, M.S.,
     Kwon, S.Y., Jeon, I., Park, S.Y., Baek, K., Yoo, M.A., Hatfield,
     D.L. and Lee, B.J.: DNA replication-related element downstream from
     the initiation site of *Drosophila* selenophosphate synthetase 2
     gene is essential for its transcription. ***Nucl. Acids Res.***
     **32:** 2482-2493, 2004.

148. Carlson, B.A., Xu, X-M., Kryukov, G.V., Rao, M., Berry, M.J.,
     Gladyshev, V.N. and Hatfield, D.L.: Identification and
     characterization of phosphoseryl-tRNA^\[Ser\]Sec^ kinase. ***Proc.
     Natl. Acad. Sci. USA*** **101:** 12848-12853, 2004. **(Featured on
     the cover and commentary written by A. Diamond entitled "On the
     road to selenocysteine", PNAS 101: 13395-13396, 2004).**

149. Carlson, B.A., Xu, X-M., Gladyshev, V.N. and Hatfield, D.L.:
     Selective rescue of selenoprotein expression in mice lacking a
     highly specialized methyl group in Sec tRNA^\[Ser\]Sec^. ***J.
     Biol. Chem.*** **280:** 5542-5548, 2005.

150. Carlson, B.A., Xu, X-M., Gladyshev, V.N. and Hatfield, D.L.: Um34
     in selenocysteine tRNA is required for the expression of
     stress-related selenoproteins in mammals. In ***Topics in Current
     Genetics***. H. Grosjean, Editor. Vol. 12, Chapter 16, p. 431-438,
     Springer-Verlag, Berlin-Heidelberg, pp. 442, 2005.

151. Shrimali, R.K., Lobanov, A.V., Xu, X-M., Mahadev, R., Carlson,
     B.A., Mahadeo, D.C., Parent, C.A., Vadim, V.N. and Hatfield, D.L.:
     Selenocysteine tRNA identification in the model organisms
     *Dictyostelium discoideum* and *Tetrahymena thermophila*.
     ***Biochem. Biophys. Res. Comm.*** **329:** 147-151, 2005.

152. Schweizer, U., Streckfus, F., Pelt, P., Carlson, B.A., Hatfield,
     D.L., Kohrle, J., Schomberg, L.: Hepatically-derived selenoprotein
     P is a key factor for kidney but not for brain selenium supply.
     ***Biochem. J.*** **386:** 221-226, 2005. **(Commentary written
     by D. Richardson entitled "More roles of selenoprotein P: local
     selenium storage and recycling protein in the brain. *Biochem. J.*
     386: e5-e7, 2005.**

153. Su, D., Novoselov, S.V., Sun, Q-A., Moustafa, M.E., Zhou, Y., Oko,
     R., Hatfield, D.L. and Gladyshev, V.N.: Mammalian selenoprotein
     thioredoxin/glutathione reductase: roles in disulfide bond
     formation and sperm maturation. ***J. Biol. Chem.*** **280:**
     26491-26498, 2005.

154. Labunsky, V.M., Ferguson, A.D., Fomenko, D.E., Chelliah, Y.,
     Hatfield, D.L. and Gladyshev, V.N.: A novel cysteine-rich domain of
     the 15-kDas selenoprotein mediates the interaction with
     UDP-glucose:glycoprotein glycosyltransferase. ***J. Biol. Chem.***
     **280:** 37839-37845, 2005.

155. Sun, Q-A., Su, D., Novoselov, S.V., Carlson, B.A., Hatfield, D.L.
     and Gladyshev, V.N.: Reaction mechanism and regulation of mammalian
     thioredoxin/glutathione reductase. ***Biochem.*** **44:**
     14528-14537, 2005.

156. Novoselov, S.V., Calvisi, D., Labunskyy, V.M., Factor, V.M.,
     Carlson, B.A., Fomenko, D.E., Moustafa, M.E., Hatfield, D.L. and
     Gladyshev, V.N.: Selenoprotein deficiency and high levels of
     selenium compounds can effectively inhibit hepatocarcinogenesis in
     transgenic mice. ***Oncogene*** **24:** 8003-8011, 2005.

157. Xu, X-M., Mix, H., Carlson, B.A., Grabowski, P.J., Gladyshev, V.N.,
     Berry, M.J., and Hatfield, D.L.: Evidence for direct roles of two
     additional factors, SECp43 and SLA, in the selenoprotein synthesis
     machinery. ***J. Biol. Chem.*** **280:** 41568-41575, 2005.

158. Hatfield, D.L.: How selenium makes its way into protein as
     selenocysteine, the 21^st^ amino acid in the genetic code. ***CCR
     Frontiers in Science***, **5:** 2006.

159. Small-Howard, A., Morozova, N., Stoytcheva, Z., Forry, E.P.,
     Mansell, J.B., Harney, J.W., Carlson, B.A., Xu, X-M., Hatfield,
     D.L. and Berry, M.J.: A supra-molecular complex mediates
     selenocysteine incorporation *in vivo*. ***Mol. Cell. Biol.***,
     **26:** 2337-2346, 2006.

160. Lobanov, A.V., Delgard, C., Rahfs, S., Novoselov, S.V., Kryudov,
     G.V., Gromer, S., Hatfield, D.L., Becker, K. and Gladyshev, V.N.
     The Plasmodium selenoproteome. ***Nucl. Acids Res.*** **34:**
     496-505, 2006.

161. Irons, R., Carlson, B.A., Hatfield, D.L. and Davis, C.D.: Both
     selenoproteins and low molecular weight selenocompounds reduce
     colon cancer risk in mice with genetically impaired selenoprotein
     expression. ***J. Nutri.*** **136:** 1311-1317, 2006.

162. Yoo, M.-H., Xu, X.-M., Carlson, B.A., Gladyshev, V.N. and Hatfield,
     D.L. Selenoprotein thioredoxin reductase 1 deficiency reverses
     tumor phenotype and tumorigenicity of lung carcinoma cells. ***J.
     Biol. Chem.*** **281:** 13005-13008, 2006 (**Accelerated
     Publication**).

163. Hatfield, D.L., Xu, X-M., Carlson, B.A., Zhong, N. and Gladyshev,
     V.N.: Selenocysteine incorporation machinery and the role of
     selenoproteins in health. ***Prog. Nucl. Acid. Res. Mol. Biol.***
     **81:** 97-142, 2006.

164. Lobanov, A.V., Kryukov, G.V., Hatfield, D.L. and Gladyshev, V.N. Is
     there a 23^rd^ amino acid in the genetic code? ***Trends in
     Genetics*** **22:** 357-360, 2006.

165. Hatfield, D.L., Berry, M.J. and Gladyshev, V.N. (Editors):
     ***Selenium*: *Its molecular biology and role in human health.***
     2^nd^ Edition. Springer Science+Business Media, LLC, New York, NY,
     2006.

166. Hatfield, D.L., Berry, M.J. and Gladyshev, V.N.: Preface. In
     ***Selenium: Its molecular biology and role in human health.***
     (2^nd^ Edition) Hatfield, D.L., Berry, M.J. and Gladyshev, V.N.
     (Editors), 2^nd^ Edition. Springer Science+Business Media, LLC, New
     York, NY, 2006.

167. Carlson, B.A., Xu, S.-M., Shrimali, R., Sengupta, A., Yoo, M.-H.,
     Irons, R., Zhong, N., Hatfield, D.L., Lee, B.J., Lobanov, A.V. and
     V.N. Gladyshev: Mammalian and other eukaryotic selenocysteine
     tRNAs. In ***Selenium: Its molecular biology and role in human
     health.*** (2^nd^ Edition) Hatfield, D.L., Berry, M.J. and
     Gladyshev, V.N., Editors. Chapter 3. 2^nd^ Edition. Springer
     Science+Business Media, LLC, New York, NY, 2006.

168. Salinas, G., Romero, H., Xu, X.-M., Carlson, B.A., Hatfield, D.L.
     and Gladyshev: Evolution of Sec decoding and the key role of
     selenophosphate synthetase in the pathway of selenium utilization.
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170. Carlson, B.A., Xu, X.-M., Shrimali, R., Sengupta, A., Yoo, M.-H.,
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171. Chen, C.L., Shim, M.S., Chung, J., Yoo, H.-S., Ha, M.J., Kim, J.Y.,
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172. Xu, X.-M., Carlson, B.A., Mix, H., Zhang, Y., Saira, K., Glass,
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173. Shrimali, R.K., Weaver, J.A., Miller, G.F., Carlson, B.A.,
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174. Carlson, B.A., Xu, X.-M, Shrimali, R.K., Sengupta, A., Yoo, M.-H.,
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175. Labunskyy, V.M., Hatfield, D.L. and Gladyshev, V.N.: The Sep15
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176. Novoselov, S.V., Lobanov, A.V., Hua, D., Kasaikina, M.V., Hatfield,
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177. Xu, X.-M., Carlson, B.A., Irons. R.A., Mix, H., Zhong, N.,
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178. Xu, X.-M., Carlson, B.A., Zhang, Y., Mix, H., Kryukov, G.V., Glass,
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179. Novoselov, S.V., Kryukov, G.V., Xu, X.-M., Carlson, B.A., Hatfield,
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180. Sheridan, P.A., Zhong, N., Carlson, B.A., Perella, C.M., Hatfield,
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181. Hatfield, D.L. Thioredoxin reductase 1: A double-edged sword in
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182. Yoo, M.-H., Xu, X.-M., Turanov, A.A., Carlson, B.A., Gladyshev,
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183. Dikiy, A., Novoselov, S.V., Fomenko, D.E., Sengupta, A., Carlson,
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184. Glass, R.S., Berry, M.J., Block, E., Boakye, H.T., Carlson, B.A.,
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     Yamdagni, R., and Zhang, Y.: Insights into the chemical biology of
     selenium. ***Phosphorus Sulfur Silicon Relat. Elem.*** (In press).