**CURRICULUM VITAE**

# 

[Name:]{.underline} Terry Van Dyke, Ph.D.

[Citizenship:]{.underline} U.S.A.

[Education:]{.underline}

> > 1977 B.S. (Interdisciplinary Studies), University of Florida,
> > Gainesville, Florida.
>
> > 1981 Ph.D. (Medical Sciences), University of Florida, Gainesville,
> > Florida

[Brief Chronology of Employment:]{.underline}

> 1981-1982 Postdoctoral Research Fellow, Department of Biochemistry,
> University of Florida
>
> 1982-1984 Postdoctoral Research Fellow, Microbiology Department, SUNY,
> Stony Brook
>
> 1984-1986 Research Associate, Department of Molecular Biology,
> Princeton University
>
> 1986-1992 Assistant Professor, Department of Biological Sciences,
> University of Pittsburgh
>
> 1992-1993 Director: Transgenic Facility, Department of Biological
> Sciences and Pediatrics, University of Pittsburgh and Children's
> Hospital of Pittsburgh
>
> Associate Professor, Department of Biological Sciences, University of
> Pittsburgh
>
> 1993-1997 Associate Professor, Department of Biochemistry and
> Biophysics, University of North Carolina at Chapel Hill
>
> 1997-2002 Professor, Department of Biochemistry and Biophysics,
> University of North Carolina at Chapel Hill
>
> 1998-present Facility Director, UNC Animal Models Core, University of
> North Carolina at Chapel Hill
>
> 1999-2001 Director UNC, Mutant Mouse Regional Resource Center,
> University of North Carolina at Chapel Hill
>
> 2002-present Sarah Graham Kenan Distinguished Professor, Department of
> Genetics, University of North Carolina at Chapel Hill -- Primary
> appointment
>
> Joint Appointment, Department of Biochemistry and Biophysics,
> University of North Carolina at Chapel Hill -- Secondary (adjunct)
> appointment
>
> Present Director, Mouse Cancer Genetics Program, National Cancer
> Institute, Frederick, Maryland
>
> Director, Center for Advanced Preclinical Research, National Cancer
> Institute, Frederick, Maryland
>
> Head, Cancer Pathways and Mechanisms Section, Mouse Cancer Genetics
> Program, National Cancer Institute, Frederick, Maryland

[Honors and Other Special Scientific Recognition:]{.underline}

1981. NIH Pre-doctoral Trainee

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1981. Medical Guild Graduate Student Research Award

1982. Damon Runio Fellowship (declined)

      1982-1984 ACS Postdoctoral Fellow

> 1992-1997 Research Career Development Award, NCI
>
> 1996 Gordon Cancer Conference Vice-Chair
>
> 1996 AACR Annual Meeting Workshop, Chair

1997 Gordon Conference (Cancer), Chair

1997 AACR Annual Meeting Symposium Chair

1999-2002 Mouse Models of Human Cancer Consortium Co-Chair

1999-present Editorial Board, MCB

2001-present Editorial Board, Cancer Cell

2001-present Editorial Board, Carcinogenesis

2002 ASCB Annual Meeting Symposium Chair

2002-present Editorial Board, Molecular Cancer Research

2002-present Editorial Board, International Journal of Oncology

2003-present Editorial Board, Cancer Research

2003 Organizer, AACR Special Meeting; Mouse Models of Cancer

2004 Organizer, Mouse Models of Cancer Symposium, AACR Annual Meeting

2006 Organizer, 30^th^ Annual Lineberger Symposium. Models of Human
Cancer at the Edge of Discovery

> 2007-present Editorial Board, The Cancer Journal: The Journal of
> Principles & Practice of Oncology

2007 Organizer, UNC-CH Lineberger Comprehensive Cancer Center, Mouse
Models Mini Symposia

2007 Organizer, Keystone Conference, Mouse Models at the Frontiers of
Cancer Discovery

2007 Chair, Salk Institute Meeting on Mechanisms and Models of Cancer
Meeting, Stanford, CA

2007 Award, sarah Graham Kenan Distinguished Professor, UNC-CH School of
Medicine

> 2008 Chair, Mouse Models Session, NCI Frontiers in Cancer Prevention
> Symposium
>
> 2008 Chair, Animal Models and Other Models Organisms Subcommittee of
> the Tumor Biology Section of the 2008 AACR Program Committee

2008 Co-Author, Chapter: "Mouse Models for Cancer Research"

Co-Author, Chapter: "Biology of the Cancer Cell: An Overview" 8^th^
Edition "Cancer: Principles and Practice of Oncology"

[Scientific Memberships:]{.underline}

Pittsburgh Cancer Institute (1986-1993)

Pittsburgh Committee on Virology (1988-1993)

UNC Program in Molecular Biology and Biotechnology (1993-present)

UNC Lineberger Comprehensive Cancer Center (1993-present)

UNC Curriculum in Neurobiology (1994-present)

UNC Curriculum in Genetics and Molecular Biology (1994-present)

American Society for Microbiology

American Association for the Advancement of Science

American Association for Cancer Research

New York Academy of Sciences

# [Committees and Boards:]{.underline}

National Committees:

Ad hoc MBY Study Section (1991 -- 1993)

Member, NIH Molecular Biology Study Section (1993 -- 1997)

Army Breast Cancer Program Review (1996, 2003)

> Preclinical Models Working group, co-chair sub group 2; Advisory to
> NCI (1997 -- 1999)
>
> AACR Special Meeting Committee (1998 -- 2001)
>
> Co-Chair, Preclinical Models of Human Cancer Consortium (NCI
> supported) (1999 -- 2002)
>
> Steering Committee, Mutant Mouse Resource Centers (NCRR supported)
> (1999 -2002)

External Advisory Board, Dana Farber Brain Tumor P01 (2002 -- present)

> External Advisory Board, National Functional Genomics Center (2003 --
> present)

External Advisory Board, Univ. Tenn. Cancer Center (2003 -- present)

> AACR Search Committee for the Cancer Research Editor-in-Chief
> (2005-Present)

External Advisory Board, Mouse Genome Database, Jackson Labs, Bar
Harbor, ME (2006-present)

Association of Women Faculty and Professionals (Present)

Jackson Laboratories Board of Scientific Overseers (2007-present)

University of Pittsburgh:

> Animal Facilities Committee, 1/87 - 8/93

Graduate Admissions Committee, 1988-90

ACS Institutional Research Grant Review Committee, Pittsburgh Cancer
Institute, 1988-90

> Steering Committee, Internal Chair Search, 1989

Pymatuning Organization Committee (Off-Campus Symposium), 1989

> Chair Search Committee, 1989-90
>
> Graduate Testing and Evaluation Committee, 1990-1992
>
> Pittsburgh Committee on Virology, 1990-1993
>
> Pittsburgh Cancer Institute, Postdoctoral Award Review Committee,
> 1991-1993

Child Health Research Center Grant, Department of Pediatrics, University
of Pittsburgh, 1991

Medical Scientist Training Program, Training Faculty, Joint Project:
University of Pittsburgh and Carnegie Mellon University, 1991-1993

University of North Carolina at Chapel Hill:

Department of Biochemistry and Biophysics, First Year Graduate Advisory,
1993-1996

Department of Biochemistry and Biophysics, Graduate Program Advisory,
1993-1996

Transgenic Facility Advisory Committee, 1993-present

Lineberger Comprehensive Cancer Center Faculty Search Committee,
1994-1996 and 1998-2000

> Lineberger Comprehensive Cancer Center Seminar Series, 1994-1995
>
> Cellular and Molecular Biology Executive Training, 1994-present
>
> Curriculum in Genetics and Molecular Biology Exam, 1994-1997
>
> Human Disease Models Core Facility, 1995-present
>
> LCCC Postdoctoral Screening Committee, 1996-present
>
> PMBB Faculty Search Committee, 1998
>
> Genetics Advisory Committee, 1998-present
>
> Faculty Animal Committee, 1999-present
>
> Genetics Director Search Committee, 1999-2000

Physiology Cancer Search Committee, 2000-2001

Task force on Imaging at UNC, 2002-present

Genetics faculty search committee, 2002-2003

> Genetics faculty mentoring committees, 2002-present
>
> Research Advisory Committee, 2004-present
>
> Salary Equity Committee, 2004-present
>
> Genetics Advisory Committee, 2005-present
>
> Mammalian Genotyping Core Oversight Committee, 2005-present
>
> The Association of Women Faculty and Professionals, 2006
>
> Advisory Committee, School of Medicine, 2006

Additional peer review:

NIH, Various Program Project and Ad Hoc Review Committees, 1987-present

Goldhirsch Foundation Advisory Committee, 2002-2005

Samuel Waxman Cancer Research Foundation's Scientific Review, Present

[Committee Chair:]{.underline}

University of Pittsburgh:

> Animal Facilities Committee, 1989 - 91
>
> Departmental Symposium Organization Committee (Co-chair), 1989

Graduate Program Oversight Committee (Program Director), 9/90-9/92

> Graduate Curriculum Committee, 9/90-9/92
>
> Director: Transgenic Facility University of Pittsburgh Depts. of
> Biological Sciences and Pediatrics, and Children\'s Hospital of
> Pittsburgh, 4/92-7/93

University of North Carolina at Chapel Hill:

> Genetics Program Seminar Director, 1997-98
>
> Program in Molecular Biology & Biotechnology, Faculty Search
>
> Director, UNC-CH Animal Models Core
>
> PMBB Faculty Search 1999 - 2000

National:

> Co-Chair, Preclinical Models for Cancer, Working Group 2 (Advisory to
> NCI),
>
> March 1997 -- present
>
> AACR Special Meeting Committee, 1998-present
>
> Co-Chair, Consortium on Preclinical Mouse Models of Cancer, October
> 1999-January 2002

# 

# [Ad Hoc Reviewer:]{.underline} 

> Cancer Research

#  Carcinogenesis

Cancer Cell

Cell

EMBO J.

Genes and Development

In Vitro

Journal of Cell Biology

Journal of Virology

Molecular Cell

Molecular and Cellular Biology

Nature

Nature Genetics

Nature Medicine

Oncogene

Proc. Natl. Acad. Sci., USA

Science

The Journal of Clinical Investigation

Virology

[Teaching Activity:]{.underline}

University of Florida:

Microbiology Laboratory, Spring 1978 and Fall 1979

Microbiology Laboratory for Medical Students, Spring 1979

Medical Virology for Physicians\' Assistants, lecturer, Winter 1981

Princeton University:

Genetics Colloquium, lecturer, Fall 1984 and 1985

University of Pittsburgh:

Developmental Mechanisms (graduate) B.S. 2770, Spring 1987, 1988, and
1989

Advanced Molecular Genetics (undergraduate), B.S. 1950, Spring 1988,
1990 - Designed Course

Developmental Biology (graduate), B.S. 2010, Spring 1989, 1990, 1991

Graduate Seminar, B.S. 2450, Fall 1990

> Current Topics in Molecular, Cell and Developmental Biology (a modular
> year-long core course for first year graduate students); Coordinator,
> 1991-1992 - Designed Course

Molecular Biology (undergraduate), BS1940, Fall 1992

Cell Proliferation Module, MCDB Graduate Core Course, Spring 1992 and
1993

University of North Carolina at Chapel Hill:

Graduate Molecular Biology, Biochemistry 105, Fall 1994 -- 2000

Invited Lectures (since 1995):

\"DNA Tumor Virus Transforming Proteins\", Micro 130, Fall 1995

\"p53 and Other Tumor Suppressors\", Phco 221, Spring 1995

\"p53: Cell Cycle and Apoptosis\", Micro 156, Spring 1995

> \"In vivo Analysis of CDK Inhibitor Function and Tumor Suppressor
> Pathways\", Carolina Workshop, Summer 1995

Visiting Undergraduate Program, Biochemistry 408, Summer 1997

> \"The Use of Transgenic Mice in Carcinogenesis Research,\" Seminar in
> Carcinogenesis, Toxicology 292, Fall 1997

Case Study Directed, Med School Biochemistry Course, Fall 1997

> \"How the p53 Protein Controls the Cell Cycle and Cancer,\" Special
> Undergraduate Course, James M. Johnson Scholarship Program - Genetics
> Research: Design, Interpretation and Impact, Spring 1998

Genetics 320, Spring 1999

Cancer Pathobiology, Pathology 225, Spring 1999, 2000

Pharmacology 221, Fall 1998, 2002, 2002

\"Animal Models and Cancer\" Super Cell Course, Spring 2000, 2003

Other:

> Washington University: Instructor and organizer for mini-symposium on
> transgenic mouse methodology, 1987
>
> North Carolina Association for Biomedical Research Workshop for K-12
> Teachers, 1995

**[INVITED TALKS]{.underline}** (Since 1996)

1996. AACR Meeting on Cancer Susceptibility Genes and Molecular
      Carcinogenesis,

Keystone, CO

AACR Annual Meeting, Workshop Organizer and Chair, Washington, DC

Lineberger Comprehensive Cancer Center Symposium

Columbia College of Physicians & Surgeons Symposium, \"The Cell Cycle\"

Vice-Chair, Gordon Conference on Cancer, Newport, RI

> AASLD Research Workshop on Transgenic Mouse Models in the Study of
> Liver Disease, Chicago, IL

1997 AACR Symposia on Molecular and Cellular Biology, Keystone, CO

> AACR Annual Meeting on Animal Models for Functional Analysis of Tumor
> Suppressor Genes, San Diego, CA
>
> Chair, Gordon Conference on Cancer, Newport, RI
>
> Aspen Cancer Conference on mechanisms of Toxicity and Carcinogenesis
>
> AACR/EACR Second Joint Conference - Molecular Genetics of Cancer,
> Oxford, England

1998 Experimental Biology \'98, San Francisco, CA

14th Annual Meeting on Oncogenes, San Diego, CA

The Pezcoller Symposia, Trento, Italy

Gordon Conference on Cancer, Salve Regina, RI

1999 AACR Special Meeting: The Mutant Mouse in Cancer, Keystone CO

UNC Lineberger Symposium

Keystone Conference: The Molecular Basis of Cancer, Taos, NM

AACR 90^th^ Annual Meeting, Philadelphia, PA

UICC Study Group Meeting: Animal Models for the Natural History of
Cancer,

Woods Hole, MA

14^th^ Aspen Cancer Conference, Aspen,CO

Gordon Research Conference on Cancer, Newport, RI

2000 Session Chair Mouse Models of Cancer, San Francisco, CA

Annual p53 Workshop, Monterey, CA

Gordon Research Conference on Cancer, Newport, RI

> Nervous System Cancers, NCI-sponsored international workshop, NYC, NY
>
> American Association for Cancer Research, Mouse Models of Human
> Cancers

2001 Keystone Symposium on Molecular & Cellular Biology, Taos, NM
(session chair)

> Symposium on Angiogenesis, NCI sponsored, UCSF
>
> Gordon Research Conference on Cancer, Newport, RI (session chair)

2002 NCI US/Japan Workshop -- Mouse Models of Cancer, Hawaii

AACR Annual Meeting, San Francisco, CA, Symposium Speaker

11^th^ International p53 Workshop, Barcelona, Spain

Cancer Intervention 2002, Grand Rapid, MI

Society for Neuroscience, Orlando, FL, Symposium Speaker

ASCB, San Francisco, FL, Symposium organizer and speaker

Society for Neuroncology, San Diego, CA

2003. Organizer: AACR Mouse Models of Cancer, Orlando FL

> UICC Study Group Meeting, Woodshole, MA.
>
> Joint SPORE-MMHCC Meeting on Astrocytoma, Baltimore, MD.
>
> Oncogenes and Growth Control, Salk Institute, LaJolla, CA.
>
> Signal Transduction Determining the Fate of Stem Cells -- ASCB Special
> Meeting
>
> Bozeman, MT.
>
> Harvard/MIT Retreat; Colrain, MA

2004. Mouse Models of Human Cancer Consortium Meeting, Los Angeles, CA.

Mouse Models of Cancer, Keystone, CO.; session chair and speaker

> Mouse Models of Cancer Symposium, AACR Annual Meeting, organizer and
> speaker
>
> NCI Mouse Cancer Genetics Retreat, keynote speaker; Western Maryland
>
> 20^th^ Anniversary Meeting on Oncogenes, Frederick, MD
>
> Cancer Genetics and Tumor Suppressor Genes, Session Chair, Cold Spring
> Harbor, NY
>
> 11th Annual Prostate Cancer Foundation Scientific Retreat
>
> International Conference on Tumor Progression and Therapeutic
> Resistance,
>
> Philadelphia, PA

2005. Keystone Symposium: The Role of Microenvironment in Tumor
      Induction and

Progression, Banff Canada

> AACR Annual Meeting, Anaheim, CA. Program Committee;
>
> AACR Annual Meeting, Symposium Organizer and speaker; Anaheim, CA.
>
> 70th Cold Spring Harbor Symposium: Molecular Approaches to Controlling
> Cancer
>
> Keynote Speaker, Mouse Models of Human Cancer Consortium: Nervous
> System
>
> Tumor Working Group
>
> Mouse Models of Human Cancer Consortium: Steering Committee Meeting

Gordon Research Conference, Bryant College, Smithfield, RI; session
chair and

speaker

2006 Keynote Speaker, Timberline Symposium -- Epithelial Cancers, Mt.
Hood, Oregon;

AACR Annual Meeting, Washington, DC; Symposium speaker

> 30th Annual Lineberger Symposium. Models of Human Cancer at the Edge
> of
>
> Discovery; Organizer and Speaker

International Conference on Brain Tumor Research and Therapy, Napa, CA

NFGC 4^th^ Annual External Advisory Board Meeting, Clearwater Beach, FL

UNC Department of Genetics Scientific Retreat, Organizer, Wrightsville,
NC

Keynote Speaker, AACR Mouse Models of Cancer Conference, Cambridge, MA

Joint NCI Mouse Models of Human Cancers Consortium and Integrative
Cancer

Biology Program Meeting, Bethesda, MD, Speaker

2007 Organizer, Keystone Symposia Mouse Models at the Frontiers of
Cancer Discovery, Whistler, British Columbia

NCI Mouse Cancer Genetics Program Meeting, Frederick, MD

AACR Annual Meeting Symposium, Los Angeles, CA

NFGC 5^th^ Annual External Advisory Board Meeting, Clearwater Beach, FL

NCI Mouse Models of Human Cancers Consortium Steering Committee Meeting,
Boston, MA

NCI Mouse Cancer Models and Early Interventions Think Tank Meeting,
Rockville, MD

NCI Animal Models Workshop, Rockville, MD

Early Detection Research Network Proteomic Interest Group Investigators
Meeting, Rockville, MD

PCF Prostate Cancer Models Scientific Working Group Meeting, Santa
Monica, CA

Board of Scientific Overseers Meeting, Bar Harbor, ME

NCI Nanotechnology Alliance Investigators Meeting, Chapel Hill, NC

Salk Institute Meeting on Mechanisms and Models of Cancer, Stanford, CA

Damon Runyon Cancer Research Foundations Scientific Advisory Committee
Meeting, New York, NY

NCI Nanotechnology Alliance Investigators Meeting; Chapel Hill, NC

SAIC Advanced Technology Program Retreat; Sheppardstown, WV

NCI Board of Scientific Counselors Meeting; Bethesda, MD

MMS SNO Meeting and Education Day; Grapevine, TX

2008. National Institute of Neurological Disorders and Stroke mTOR
      Workshop, Bethesda, MD (declined)

      SAIC-Frederick, Inc. Scientific Gathering (Seminar), Fort Detrick,
      MD

      ASM Conference on Manipulation of Nuclear Processes by DNA Viruses
      Meeting, Charleston, SC

      MMHCC Steering Committee Meeting, Colorado Springs, CO

      14^th^ International p53 Workshop, Institute of Biosciences, Fudan
      University, Shanghai City, China

**[BIBLIOGRAPHY]{.underline}**

1.  Flanegan, J.B., and **Van Dyke, T.A.** (1980)" Isolation of a
    soluble and template dependent poliovirus RNA polymerase that copies
    virion RNA in vitro" [J. Virol.,]{.underline} 35:155-161, 1980

2.  **Van Dyke, T.A.** and Flanegan, J.B. (1980) "Identification of
    poliovirus polypeptide p63 as a soluble RNA dependent RNA
    polymerase". [J. Virol.,]{.underline} 35:732-740, 1980

3.  Flanegan, J.B., **Van Dyke, T.A.** and Rickles, R.J. (1981) "
    Characterization of the poliovirus RNA dependent RNA polymerase and
    its in vitro RNA product". In: D. Schlessinger (ed) Microbiology,
    1984 p. 30-34, 1981

4.  **Van Dyke, T.A.**, Flanegan, J.B. and Rickles, R. (1982)
    "Genome-length copies of poliovirus are synthesized in vitro by
    poliovirus RNA dependent RNA polymerase". [J. Biol.
    Chem]{.underline}., 257: 4610-4617, 1982

5.  Sierra, F., Lichtler, A., Marashi, F., Rickles, R., **Van Dyke,
    T.A.**, Clark, S., Wells, J., Stein, G. and Stein, J. (1982)
    "Organization of human histone genes". [Proc. Natl. Acad. Sci.
    USA]{.underline}, 9:972-1977, 1982

6.  Sierra, F., Leza, A., Marashi, F., Plumb, M., Rickles, R., **Van
    Dyke, T.A.**, Clark, S., Wells, J., Stein, G.S. and Stein,
    J.L.(1982) "Human histone genes are interspersed with members of the
    alu family and with other transcribed sequences". [Biochem. Biophys.
    Res. Commun.,]{.underline} 104:785-792, 1982

7.  Brinster, R., Chen, H.Y., Messing, A., **Van Dyke, T.A.,** Levine,
    A.J. and Palmiter, R.(1984) "Transgenic mice harboring SV40 T
    antigen genes develop characteristic brain tumors".
    [Cell,]{.underline} 37:367-379, 1984

8.  **Van Dyke, T**., Finlay, C. and Levine, A.J. (1985)
    "Characterization of several lines of mice transmitting the SV40
    early-region genes in the germ lines". [Cold Spring Harb Symp.
    Quant. Biol]{.underline}*.*, 50:671-8, 1985

9.  Yagaloff, K.A., Lozano, G., **Van Dyke, T.** (1986) "Levine, A.J.
    and Hartig, P.R. Serotonin 5-HT~1C~ receptors are expressed at high
    density on choroid plexus tumors from transgenic mice". [Brain
    Res.,]{.underline}385:389-94, 1986

10. **Van Dyke, T.A.**, Finlay, C., Miller, D., Marks, J., Lozano, G.
    and Levine, A.J.(1987) "The relationship between Simian Virus 40
    large tumor antigen expression and tumor formation in transgenic
    mice". [J. Virol.,]{.underline} 61:2029-2032, 1987

11. Lubbert, H., B.J. Hoffman, T.P. Snutch, T. **Van Dyke, A.** J.
    Levine, P.R. Hartig, H.A. Lester, and N. Davidson. (1987) "cDNA
    cloning of a serotonin 5-HT1C receptor by electrophysiological
    assays of mRNA-injected Xenopus oocytes". [PNAS,]{.underline}
    84:4332-4336, 1987

12. Chen, J., K. Nielson, and **T. Van Dyke.** (1989) "The Lymphotropic
    Papovavirus Early Region Induces Neoplasia of the Choroid Plexus and
    Lymphoid Cells in Transgenic Mice". [J. Virol]{.underline}.,
    63:2204-2214, 1989

13. Yan, C., Costa, R., Darnell, J.E., Chen, J., and **Van Dyke,
    T.A.**, (1990) "Distinct Positive and Negative Elements Control the
    Limited Hepatocyte and Choroid Plexus Expression of Transthyretin in
    Transgenic Mice". [EMBO J.,]{.underline} 9:869-878, 1990

14. Dyson, N., Bernards, R., Friend, S., Gooding, L., Hassel, J., Major,
    E., Pipas, J., Prives, C., **Van Dyke, T.,** and Harlow, E. (1990)
    "The large T antigens of many polyoma viruses are able to form
    complexes with the retinoblastoma protein". [J. Virol.,]{.underline}
    64:1353-1356, 1990

15. Koretsky, A., Brosnan, J., Chen, L.H., Chen, J., and **Van Dyke,
    T.A.** (1990) "NMR detection of creatine kinase expressed in liver
    of transgenic mice: Determination of free ADP levels". [Proc. Natl.
    Acad. Sci. USA]{.underline},87:3112-3116, 1990

16. Costa, R.H., **Van Dyke, T.A.** Yan, C., Kuo, F., and Darnell,
    J.E.(1990) "Similarities in transthyretin gene expression and
    differences in transcription factors: hepatocytes and the yolk sac
    compared to the choroid plexus". [Proc. Natl. Acad. Sci.,
    USA]{.underline}*.,*87:6589-6593, 1990

17. Brosnan, J., Chen, L., **Van Dyke, T.,** and Koretsky, A.P.(1990)
    "Free ADP levels in transgenic mouse liver expressing creatine
    kinase: effects of enzyme activity, phosphagen type and substrate
    concentration". [J. Biol. Chem]{.underline}., 265:20849-20855, 1990

18. Brosnan, J., Chen, L., Wheeler, C.E., **Van Dyke, T.** and
    Koretsky, A. (1991) "Phosphocreatine protects hepatic ATP from a
    fructose load in transgenic mouse liver expressing creatine kinase".
    [Am. J.Physiology.]{.underline} 260:1191-1200, 1991

19. Symonds, H., Chen, J., and **Van Dyke, T.** (1991) "Complex
    Formation Between the Lymphotropic Papovavirus Large Tumor Antigen
    and the Tumor Suppressor Protein, p53". [J. Virol.]{.underline}
    65:5417-5424, 1991

20. Chen, J. and **Van Dyke, T.A.** (1991) "Uniform Cell-Autonomous
    Tumorigenesis of the Choroid Plexus by Papovaviral Large T
    Antigens". [Mol. Cell. Biology]{.underline}. 11:5968-5976, 1991

21. Chen, J., Tobin, G., Pipas, J., and **Van Dyke, T.A.** (1992) "T
    Antigen Mutant Activities In Vivo: Roles of p53 and pRB Binding in
    Tumorigenesis of the [Choroid Plexus Oncology]{.underline}.
    7:1167-1175, 1992

22. **Van Dyke T.A.** (1993) "Tumors of Choroid Plexus, in Molecular
    Genetics of Nervous System Tumors", Levine and Schmidek editors,
    publisher *Wiley & Sons*, p287-301, 1993

23. Symonds, H., McCarthy, S., Chen, J., Pipas, J.M., and **T. Van
    Dyke.** (1993) "Use of Transgenic Mice Reveals Cell-Specific
    Transformation by an SV40 T Antigen Amino-Terminal Mutant". [Mol
    Cell. Biol]{.underline}*.*, 13:3255-3265, 1993

24. **Van Dyke, T. (1994) "**Analysis of viral-host protein interactions
    and tumorigenesis in transgenic mice". [Semin. in Cancer
    Biol]{.underline}*.*, 5:47-60, 1994

25. McCarthy, S. A., Symonds, H. S. and **T. Van Dyke.** (1994) "
    Regulation of apoptosis in transgenic mice by SV40 T
    antigen-mediated inactivation of p53", [Proc. Natl. Acad. Sci.
    USA]{.underline}, 91:3979-3983, 1994

26. Saenz Robles, M.T., Symonds, H. S., Chen, J., and **T. Van
    Dyke.** (1994) "Induction versus progression of brain tumor
    development: Differential functions for the pRB- and p53-targeting
    domains of SV40 T antigen", [Mol. Cell. Biol]{.underline}.,
    14:2686-2698, 1994

27. Symonds, H., Krall, L., Remington, L., Saénz Robles, M., Lowe S.,
    Jacks, T., and **T. Van Dyke. (**1994) "p53 Dependent apoptosis
    suppresses tumor growth and progression in vivo",
    [Cell,]{.underline} 78:703-711, 1994

28. Symonds, H., Krall, L., Remington, L, Saénz Robles, M., Lowe, S.,
    Jacks, T., and **T. Van Dyke.** (1994) "p53-Dependent apoptosis in
    vivo: Impact of p53 inactivation in tumorigenesis", [Cold Spring
    Harb Symp on Quant Biol]{.underline}*.*, 49:247-257, 1994

29. Wu, H., Wade, M., Krall, L., Grisham, J., Xiong, Y., and **T. Van
    Dyke.** (1996) "Targeted in vivo expression of the cyclin-dependent
    kinase inhibitor p21, halts hepatocyte cell-cycle progression,
    postnatal liver development, and regeneration", [Gen. and
    Dev]{.underline}*.*, 10:245-260, 1996

30. Bowman, T., Symonds, H., Gu, L., Oren, M., and **T. Van
    Dyke.** (1996) " Tissue-specific inactivation of p53 tumor
    suppression in the mouse", [Genes. and Dev]{.underline}*.*,
    10:826-835, 1996

31. Yin, C., Knudson, M., Korsmeyer, S., and **Van Dyke, T.** (1997)
    "Bax suppresses tumorogenesis and stimulates apoptosis in vivo",
    [Nature,]{.underline} 385:637-640, 1997

32. Li, J., Witte, D.P., **Van Dyke, T,** Askew, D.S. (1997) "Expression
    of the putative protooncogene His-1 in normal and neoplastic
    tissues", [Amer. J. of Pathology]{.underline}*.*, 150:1297-1305,
    1997

33. Patrick, T., Dranz, D., **Van Dyke, T.** and Edward Roy. (1997)
    "Folate receptors as potential therapeutic targets in choroid plexus
    tumors of SV11 transgenic mice". [J. of
    Neuro-Oncology]{.underline}*.* 32:111-123, 1997

34. Pan, H., Yin, C., and **Van Dyke, T.** (1997) "Apoptosis and cancer
    mechanisms", [Cancer Surveys,]{.underline} 29:305-327, 1997

35. Liao, M-J., Zhang, X-X., Hill, R., Gao, J.,. Qumsiyeh, MB, Nichols,
    W., and **Van Dyke, T.** (1998) "No requirement for V(D)J
    recombination in p53-Deficient thymic lymphoma". [Mol. Cell.
    Biol.,]{.underline} 18:3495-3501, 1998

36. Pan, H., Yin, C., Yamaskai, L., Dyson N., Harlow, E., and **Van
    Dyke, T.** (1998) "Key roles for E2F1 in p53-Dependent apoptosis and
    cell cycle regulation within developing tumors". [Mol.
    Cell.]{.underline} 2:283-292, 1998

37. Liao, M-J, Yin, C, Barlow, C., Wynshaw-Boris, A, and **Van Dyke,
    T.** (1999) "Atm is dispensable for p53 apoptosis and tumor
    suppression when signaled by cell cycle dysfunction". [Mol. Cell.
    Biol.]{.underline} 19:3095-3102, 1999

38. Liao, M-J and **Van Dyke, TA.** (1999) "Critical role for Atm in
    suppressing VDJ recombination-driven thymic lymphoma", [Genes and
    Dev.]{.underline} 13:1246-1250, 1999

39. de La Coste A, Mignon A, Fabre M, Gilbert E, Porteau A, **Van Dyke
    T.** Kahn A, and Perret C. (1999) "Paradoxical inhibition of
    c-myc-induced carcinogenesis by Bcl-2 in transgenic mice". [Cancer
    Res.]{.underline} 59:5017-5022, 1999

40. Salganik RI, Albright CD, Rodgers J, Kim J, Zeisel SH, Sivanshenskiy
    MS, and **Van Dyke TA.** (2000) "Antioxidant depletion: Enhancement
    of apoptotic tumor cell death and inhibition of brain tumor growth
    in transgenic mice". *[Carcinogenesis,]{.underline}* 21:909-914,
    2000

41. Lu, X., G. Magrane, D.N.Louis, J. Gray, and **T. Van Dyke.** (2001)
    "Selective inactivation of p53 facilitates mouse epithelial tumor
    Progression without Chromosomal Instability". [Mol. and Cell.
    Biol]{.underline}*.*, 21:6017-6030, 2001

42. Tolbert D, Lu X, Yin C, Tantama, M and **VanDyke TA.** (2002)
    "p19^ARF^ is Dispensible for oncogenic stress-Induced p53-dependent
    Apoptosis and Tumor Suppression in vivo". [Mol. and Cell.
    Biol]{.underline}*.*, 22:370-377, 2002

43. Perkins EJ, Nair A, Cowley DO, **Van Dyke T.** Chang Y., Ramsden
    DA. (2002) "Sensing of Intermediates in V(D)J recombination by ATM".
    [Genes and Dev.]{.underline} 16:159-64, 2002

44. **Van Dyke, T.** and T. Jacks. (2002) "Cancer Modeling in the Modern
    Era: Progress and Challenges". [Cell,]{.underline} 108:135-44, 2002

45. Xiao A, Wu H, Louis DN, Pandolfi PP, **Van Dyke TA**. (2002)
    "Astrocyte inactivation of the pRb pathway predisposes mice to
    malignant astrocytoma development that is accelerated by PTEN
    Mutation". [Cancer Cell*.*]{.underline} 1:157-68, 2002

46. Weiss, W A, Israel M., Cobbs C., Holland E., James C D, Louis D N,
    Marks Cheryl, McClatchey A., Roberts T., **Van Dyke T**. Wetmore C.,
    Chiu I., Giovannini M., Guha A., Higgins R., Marino S., Radovanovic
    I., Reilly K., Aldape K. (2002) "Neuropathology of genetically
    engineered mice". [Oncogene.]{.underline} 21;44, 2002

47. Trotman, L., Niki, M., Dotan,Z., Koutcher, J., Di Cristofano, A,
    Xiao, A, Khoo, A., Roy-Burman, Greenberg, N. , **Van Dyke, T.**,
    Cordon-Cardo, C. P.P Pandolfi.(2003) "Pten Dose Dictates Cancer
    Progression in the Prostate". [PloS Biology, PloS
    Biology]{.underline}, 1: 385-396, 2003

48. Simin, K. H. Wu, L. Lu, D. Pinkel, D. Albertson, R. Cardiff, and
    **Van Dyke TA** (2004) "pRb Inactivation in Mammary Cells
    Predisposes to Adenocarcinoma and Reveals Common Mechanisms for
    Tumor Initiation and Progression in Divergent Epithelia". [PloS
    Biology]{.underline}, 2:194-205, 2004

# Albright, C.D., Salganik, R.I., and Van Dyke TA (2004) "Dietary Depletion of Vitamin E and Vitamin A Inhibits Mammary Tumor Growth and Metastasis in Transgenic Mice". [Journal of Nutrition]{.underline}, 134(5):1139-44, 2004

49. Nistér, M., Beeche, M., Zhang, X-Q., Yin, C., Hu, X., Tang, M.,
    Enblad, G., **Van Dyke, T.**, and Wahl, G. M. (2005) "p53 must be
    competent for transcriptional regulation to suppress tumor
    formation". [Oncogene]{.underline} 24, 3563−3573, 2005

50. **Van Dyke, T** (2005) "Cancer biology: sense out of missense".
    [Nature]{.underline} 17;434(7031):287-8, 2005 (invited review)

51. Li, Chengwen, Bowles, D., R. Jude Samulski, and **Terry Van
    Dyke** (2005) "Adeno-associated virus vectors: potential
    applications for cancer gene therapy". [Cancer Gene
    Therapy]{.underline}, 2005 Dec; 12. 913-25

52. Xiao, A, C. Yin, C. Yang, A. Di Cristofano, P. Pandolfi and **T. Van
    Dyke** (2005) "Somatic Induction of Pten Loss in a Preclinical
    Astrocytoma Model Reveals Major Roles in Disease Progression and
    Avenues for Target Discovery and Validation", [Cancer
    Research.]{.underline} 2005 Jun 15; 65(12):5172-80, 2005. (Cover
    story)

53. Brubaker, L. M., E. Bullitt, C. Yin, **T. Van Dyke**, W. Lin. (2005)
    "Magnetic resonance angiography visualization of abnormal tumor
    vasculature in genetically engineered mice". [Cancer
    Research.]{.underline} Sep 15;65(18):8218-23. 2005.

54. Cowley, D., G. Muse and **Van Dyke, T.** (2005) "A Dominant
    Interfering Bub1 Mutant is Insufficient to Induce or Alter
    Tumorigenesis In Vivo, Even in a Sensitized Genetic Background".
    [Mol. Cell. Bio.]{.underline} Sept; 25(17):7796-7802, 2005

55. Hill, R., Y. Song, R. D. Cardiff, and **T. Van Dyke** (2005)
    "Heterogeneous Tumor Evolution Initiated by Loss of pRb Function in
    a preclinical Prostate Cancer Model". [Cancer Research]{.underline}.
    Nov 15;65(22):10243-54, 2005

56. Hill, R., Y. Song, R.D. Cardiff, and **T. Van Dyke**. (2005)
    "Selective evolution of stromal mesenchyme with p53 loss in response
    to epithelial tumorigenesis". [Cell]{.underline}. Dec 16;
    123(6):1001-11, 2005. (Cover story)

# 

57. Elizabeth Bullitt, P. Anne Wolthousen , Lauren Brubaker, Weili Lin,
    Donglin Zeng and **Terry Van Dyke**. (2006) "Malignancy-Associated
    Vessel Tortuosity: A Computer-Assisted, MRA Study of Choroid Plexus
    Carcinoma in Genetically Engineered Mice". [American Journal of
    Neuroradiology]{.underline} 27(3):612-9, 2006

# 

58. Gutmann DH, Maher EA, **Van Dyke T.** (2006) "Mouse Models of Human
    Cancers Consortium Workshop on Nervous System Tumors". [Cancer
    Res]{.underline}. 66(1):10-3, 2006

# 

# K. Simin, R. Hill, Y. Song, Q. Zhang, R. Bash, R.D. Cardiff, C. Yin, A. Xiao, K. McCarthy, T. Van Dyke (2006) "Deciphering Cancer Complexities in Genetically Engineered Mice" *In* Cold Spring Harbor Symposia on Quantitative Biology LXX , 2008;70:283-90, 2006

59. Bullitt E, Wolthusen PA, Brubaker L, Lin W, Zeng D, **Van Dyke
    T.** (2006) "Malignancy-associated vessel tortuosity: a
    computer-assisted, MR angiographic study of choroid plexus carcinoma
    in genetically engineered mice". [American Journal of
    Neuroradiology]{.underline} 2006 Mar; 27.612-9

60. McLear, Julie A., German Garcia-Fresco, Manzoor A. Bhat and
    **Terry A. Van Dyke** (2006) "In Vivo Inactivation of pRb, p107 and
    p130 in Murine Neuroprogenitor Cells Leads to Major CNS
    Developmental Defects Culminating in High Seizure Rates". [Mol.
    Cell. Neurosciences]{.underline}, 33:260-273, 2006 (cover article)

61. **Terry A. Van Dyke** (2007) " p53 and Tumor Suppression". [N Engl J
    Med]{.underline} 356;1, 2007

62. Bullitt, E., Stephen R Aylward, **Terry Van Dyke**, and Weili
    Lin (2007) "Computer-Assisted Measurement of Vessel Shape from 3T
    Magnetic Resonance Angiography of Mouse Brain".
    [Methods]{.underline}, 2007 Sep;43(1):29-34.

63. Johnson CE, Huang YY, Parrish AB, Smith MI, Vaughn AE, Zhang Q,
    Wright KM, **Van Dyke T,** Wechsler-Reya RJ, Kornbluth S, Deshmukh
    M (2007) "Differential Apaf-1 levels allow cytochrome c to induce
    apoptosis in brain tumors but not in normal neural tissues". [Proc
    Natl Acad Sci U S A]{.underline}. 2007 Dec 26;104(52):20820-5. Epub
    2007 Dec 18.

64. Herschkowitz JI, Simin K, Weigman VJ, Mikaelian I, Usary J, Hu Z,
    Rasmussen KE, Jones LP, Assefnia S, Chandrasekharan S, Backlund MG,
    Yin Y, Khramtsov AI, Bastein R, Quackenbush J, Glazer RI, Brown PH,
    Green JE, Kopelovich L, Furth PA, Palazzo JP, Olopade OI, Bernard
    PS, Churchill GA, **Van Dyke T,** Perou CM. (2007) "Identification
    of conserved gene expression features between murine mammary
    carcinoma models and human breast tumors". [Genome
    Biol]{.underline}. 2007;8(5):R76.

67\. [Wu Z, Sun J, Zhang T, Yin C, Yin F, **Van Dyke T**, Samulski RJ,
Monahan
PE](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18059373&dopt=Abstract).
(2008) "Optimization of Self-complementary AAV Vectors for
Liver-directed Expression Results in Sustained Correction of Hemophilia
B at Low Vector Dose". [Mol. Ther]{.underline}*.* 16: 280-9, 2008.