**The 4^th^**

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**MicroArray Quality Control**

**Project Meeting**

**FINAL AGENDA**

February 3-4, 2006

Boston, Massachusetts

<http://edkb.fda.gov/MAQC/>

> *Co-sponsored by:*

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![](media/image4.png){width="3.0902777777777777in"
height="0.29097222222222224in"}

**The MAQC-4 Project Meeting Agenda,** February 3-4, 2006

Room S3-127, Science Building, UMASS Boston Campus, Boston, MA

+-------+-------------------------------------+-----------------------+
| *     |                                     |                       |
| *[Day |                                     |                       |
| One:  |                                     |                       |
| Fr    |                                     |                       |
| iday, |                                     |                       |
| Feb   |                                     |                       |
| ruary |                                     |                       |
| 3,    |                                     |                       |
| 2006  |                                     |                       |
| ]{.ma |                                     |                       |
| rk}** |                                     |                       |
|       |                                     |                       |
| C     |                                     |                       |
| hair: |                                     |                       |
| *     |                                     |                       |
| *Rick |                                     |                       |
| Jen   |                                     |                       |
| sen** |                                     |                       |
| (     |                                     |                       |
| UMass |                                     |                       |
| Bo    |                                     |                       |
| ston) |                                     |                       |
+-------+-------------------------------------+-----------------------+
| 8:00  | Breakfast                           |                       |
| am    |                                     |                       |
+-------+-------------------------------------+-----------------------+
| 9:00  | Chair's remarks                     | Rick Jensen           |
| am    |                                     |                       |
+-------+-------------------------------------+-----------------------+
| 9:15  | The Mysterious ***P***roblem in     | Leming Shi (FDA/NCTR) |
| am    | Microarray Technology: The Origin   |                       |
|       | of Chaos in Data Analysis           |                       |
+-------+-------------------------------------+-----------------------+
| 9:40  | Standard Requirements in the        | Federico Goodsaid     |
| am    | Validation of Genomic Biomarkers    | (FDA/CDER)            |
+-------+-------------------------------------+-----------------------+
| **[   |                                     |                       |
| Issue |                                     |                       |
| 1]{.u |                                     |                       |
| nderl |                                     |                       |
| ine}: |                                     |                       |
| QC    |                                     |                       |
| Me    |                                     |                       |
| trics |                                     |                       |
| and   |                                     |                       |
| Thr   |                                     |                       |
| eshol |                                     |                       |
| ds:** |                                     |                       |
| End   |                                     |                       |
| U     |                                     |                       |
| ser's |                                     |                       |
| Pe    |                                     |                       |
| rspec |                                     |                       |
| tives |                                     |                       |
+-------+-------------------------------------+-----------------------+
| 10:10 | ***Types of metrics:***             | Discussion Team:      |
| am    |                                     |                       |
|       | 1.  Repeatability (Precision);      | **Federico Goodsaid** |
|       |                                     | (Leader)              |
|       | 2.  Reproducibility;                |                       |
|       |                                     | Cecilie Boysen        |
|       | 3.  "Accuracy".                     |                       |
|       |                                     | David Duewer          |
|       | ***Types of data comparison:***     |                       |
|       |                                     | Wendell Jones         |
|       | 1.  Intra-site;                     |                       |
|       |                                     | Yuling Luo            |
|       | 2.  Inter-site;                     |                       |
|       |                                     | Weida Tong            |
|       | 3.  Cross-platform.                 |                       |
|       |                                     | Mike Wilson           |
|       | ***Two measurement spaces:***       |                       |
|       |                                     | Russ Wolfinger        |
|       | 1.  Expressed genes: P/A;           |                       |
|       |                                     | Sheng Zhong           |
|       | 2.  Differential expressed genes:   |                       |
|       |     intensity, fold change, gene    | ***"MAQC Guidance to  |
|       |     list, *etc*.                    | Data Analysis", Draft |
|       |                                     | V3, Nov-14-2005       |
|       | ***Surrogates of "accuracy":***     | (contact Leming Shi   |
|       |                                     | for more              |
|       | 1.  Use of titration mixtures;      | information)***       |
|       |                                     |                       |
|       | 2.  False positives from self-self  |                       |
|       |     comparisons;                    |                       |
|       |                                     |                       |
|       | 3.  Concordance between platforms;  |                       |
|       |                                     |                       |
|       | 4.  Concordance with alternative    |                       |
|       |     technologies.                   |                       |
|       |                                     |                       |
|       | ***Platform-specific, single array  |                       |
|       | QC metrics:***                      |                       |
|       |                                     |                       |
|       | 1.  many ...                        |                       |
|       |                                     |                       |
|       | ***Determination of thresholds:***  |                       |
|       |                                     |                       |
|       | 1.  How good is good (normal)       |                       |
|       |     enough?                         |                       |
|       |                                     |                       |
|       | 2.  *A metric without corresponding |                       |
|       |     acceptable thresholds does not  |                       |
|       |     help much.*                     |                       |
+-------+-------------------------------------+-----------------------+
| 10:40 | **Coffee break**                    |                       |
| am    |                                     |                       |
+-------+-------------------------------------+-----------------------+
| **[   |                                     |                       |
| Issue |                                     |                       |
| 2]    |                                     |                       |
| {.und |                                     |                       |
| erlin |                                     |                       |
| e}:** |                                     |                       |
| Defin |                                     |                       |
| ition |                                     |                       |
| of    |                                     |                       |
| Orig  |                                     |                       |
| inal, |                                     |                       |
| Non-  |                                     |                       |
| norma |                                     |                       |
| lized |                                     |                       |
| Data  |                                     |                       |
| ("    |                                     |                       |
| **Ori |                                     |                       |
| ginal |                                     |                       |
| Da    |                                     |                       |
| taset |                                     |                       |
| s**") |                                     |                       |
+-------+-------------------------------------+-----------------------+
| 11:00 | ***Background correction***         | Discussion Team:      |
| am    |                                     |                       |
|       | 1.  Negative (missing) values;      | **Shawn Baker**       |
|       |                                     | (Leader)              |
|       | 2.  Offset values;                  |                       |
|       |                                     | Jim Collins           |
|       | ***Transformation***                |                       |
|       |                                     | Francoise de          |
|       | 1.  log2                            | Longueville           |
|       |                                     |                       |
|       | 2.  None?                           | Xu Guo                |
|       |                                     |                       |
|       | ***Replicating spots***             | Ernie Kawasaki        |
|       |                                     |                       |
|       | 1.  Averaging?                      | Rich Shippy           |
|       |                                     |                       |
|       | 2.  As is?                          | Yongming Sun          |
|       |                                     |                       |
|       | ***Outliers***                      | Weida Tong            |
|       |                                     |                       |
|       | 1.  Outlier arrays;                 |                       |
|       |                                     |                       |
|       | 2.  Outlier test sites;             |                       |
|       |                                     |                       |
|       | 3.  Outlier platforms.              |                       |
|       |                                     |                       |
|       | ***AFX's "original" probe set       |                       |
|       | data***                             |                       |
|       |                                     |                       |
|       | -   Non-scaled MAS5 output?         |                       |
+-------+-------------------------------------+-----------------------+
| **[   |                                     |                       |
| Issue |                                     |                       |
| 3]    |                                     |                       |
| {.und |                                     |                       |
| erlin |                                     |                       |
| e}:** |                                     |                       |
| Expr  |                                     |                       |
| essed |                                     |                       |
| Genes |                                     |                       |
| ("**P |                                     |                       |
| /A**" |                                     |                       |
| calls |                                     |                       |
| /     |                                     |                       |
| **Fla |                                     |                       |
| gs**) |                                     |                       |
+-------+-------------------------------------+-----------------------+
| 11:30 | 1.  Summary of "P/A" detection      | Discussion Team:      |
| am    |     calls;                          |                       |
|       |                                     | **Yongming Sun**      |
|       | 2.  Criteria for excluding flagged  | (Leader)              |
|       |     genes in analysis;              |                       |
|       |                                     | Shawn Baker; Jim      |
|       | 3.  Impact of flagged genes on      | Collins;              |
|       |     analysis results;               |                       |
|       |                                     | Francoise de          |
|       | 4.  Call for unified flagging       | Longueville;          |
|       |     notation/definition: P, M, and  |                       |
|       |     A?                              | Xu Guo; Ernie         |
|       |                                     | Kawasaki;             |
|       | ***Q**: What % of the genome is     |                       |
|       | expressed in a single sample (or    | Rich Shippy; Weida    |
|       | detectable by a platform)?*         | Tong                  |
+-------+-------------------------------------+-----------------------+
| 12:00 | **Lunch**                           |                       |
| pm    |                                     |                       |
+-------+-------------------------------------+-----------------------+
| C     |                                     |                       |
| hair: |                                     |                       |
| **Uwe |                                     |                       |
| Sch   |                                     |                       |
| erf** |                                     |                       |
| (FDA/ |                                     |                       |
| CDRH) |                                     |                       |
+-------+-------------------------------------+-----------------------+
| **[   |                                     |                       |
| Issue |                                     |                       |
| 4]    |                                     |                       |
| {.und |                                     |                       |
| erlin |                                     |                       |
| e}:** |                                     |                       |
| Diff  |                                     |                       |
| erent |                                     |                       |
| ially |                                     |                       |
| Expr  |                                     |                       |
| essed |                                     |                       |
| Genes |                                     |                       |
| (*    |                                     |                       |
| *D.E. |                                     |                       |
| G.**) |                                     |                       |
+-------+-------------------------------------+-----------------------+
| 1:30  | ***Normalization methods***         | Discussion Team:      |
| pm    |                                     |                       |
|       | 1.  Original;                       | **Leming Shi**        |
|       |                                     | (Leader)              |
|       | 2.  Mean- (total-) scaling;         |                       |
|       |                                     | Cecilie Boysen        |
|       | 3.  Median-scaling;                 |                       |
|       |                                     | Jim Chen              |
|       | 4.  Quantile.                       |                       |
|       |                                     | Eugene Chudin         |
|       | *(AFX: MAS5, dCHIP, RMA, PLIER16 or |                       |
|       | apply norm. to non-scaled MAS5      | Lisa Croner           |
|       | output?)*                           |                       |
|       |                                     | Lei Guo               |
|       | ***Gene ranking (selection)         |                       |
|       | methods***                          | Xu Guo                |
|       |                                     |                       |
|       | 1.  Fold change (FC);               | Rick Jensen           |
|       |                                     |                       |
|       | 2.  *P*-value;                      | Wendell Jones         |
|       |                                     |                       |
|       | 3.  FC+*P*;                         | Walter Liggett (5     |
|       |                                     | min. pres.)           |
|       | 4.  *P*+FC;                         |                       |
|       |                                     | Weida Tong            |
|       | 5.  SAM;                            |                       |
|       |                                     | Sue-Jane Wang         |
|       | 6.  FDR.                            |                       |
|       |                                     | Russ Wolfinger        |
|       | -   ***"What are we detecting with  |                       |
|       |     microarrays?"***                |                       |
|       |                                     |                       |
|       | -   ***Multi-array based            |                       |
|       |     normalization: Why? Practical   |                       |
|       |     implications?***                |                       |
+-------+-------------------------------------+-----------------------+
| **[   |                                     |                       |
| Issue |                                     |                       |
| 5]{.u |                                     |                       |
| nderl |                                     |                       |
| ine}: |                                     |                       |
| Cr    |                                     |                       |
| oss-p |                                     |                       |
| latfo |                                     |                       |
| rm**: |                                     |                       |
| Probe |                                     |                       |
| Seq   |                                     |                       |
| uence |                                     |                       |
| Ma    |                                     |                       |
| pping |                                     |                       |
| and   |                                     |                       |
| Data  |                                     |                       |
| Compa |                                     |                       |
| rison |                                     |                       |
+-------+-------------------------------------+-----------------------+
| 2:00  | ***Mapping to RefSeq transcripts*** | Discussion Team:      |
| pm    |                                     |                       |
|       | 1.  Database version                | **Damir Herman**      |
|       |                                     | (Leader)              |
|       | 2.  Mapping results                 |                       |
|       |                                     | Shawn Baker           |
|       | ***Mapping to AceView genes***      |                       |
|       |                                     | Rick Jensen           |
|       | 1.  Database version                |                       |
|       |                                     | Scott Pine            |
|       | 2.  Mapping results                 |                       |
|       |                                     | Zoltan Szallasi       |
|       | ***Handling different mapping       |                       |
|       | relations***                        | Jean Thierry-Mieg     |
|       |                                     |                       |
|       | -   1-1; 1-n; n-1; n-n.             | Chunlin Xiao          |
|       |                                     |                       |
|       | ***Master mapping index***          |                       |
|       |                                     |                       |
|       | ***Cross-platform data comparison   |                       |
|       | under different mapping scenarios   |                       |
|       | (3'-bias, probe proximity, etc.)*** |                       |
|       |                                     |                       |
|       | -   How much does it really matter? |                       |
|       |                                     |                       |
|       | ***Call for public release of       |                       |
|       | probe/primer sequences***           |                       |
+-------+-------------------------------------+-----------------------+
| **[   |                                     |                       |
| Issue |                                     |                       |
| 6]{.u |                                     |                       |
| nderl |                                     |                       |
| ine}: |                                     |                       |
| Appl  |                                     |                       |
| icati |                                     |                       |
| ons** |                                     |                       |
| of    |                                     |                       |
| MAQC  |                                     |                       |
| Out   |                                     |                       |
| comes |                                     |                       |
+-------+-------------------------------------+-----------------------+
| 2:30  | Applications of MAQC reference RNA  | Mike Wilson           |
| pm    | samples and reference datasets for  |                       |
|       | performance validation              |                       |
+-------+-------------------------------------+-----------------------+
| 2:50  | Assessing the performance of H25K   | Mark Schena           |
| pm    | platform                            |                       |
+-------+-------------------------------------+-----------------------+
| 3:10  | "Baseline practices document" for   | Federico Goodsaid     |
| pm    | the submission and analysis of VGDS |                       |
|       | data sets                           |                       |
+-------+-------------------------------------+-----------------------+
| 3:30  | **Coffee break**                    |                       |
| pm    |                                     |                       |
+-------+-------------------------------------+-----------------------+
| *     |                                     |                       |
| *Open |                                     |                       |
| Di    |                                     |                       |
| scuss |                                     |                       |
| ions/ |                                     |                       |
| Prese |                                     |                       |
| ntati |                                     |                       |
| ons** |                                     |                       |
| C     |                                     |                       |
| hair: |                                     |                       |
| **Fed |                                     |                       |
| erico |                                     |                       |
| Goods |                                     |                       |
| aid** |                                     |                       |
| (FDA/ |                                     |                       |
| CDER) |                                     |                       |
+-------+-------------------------------------+-----------------------+
| 3:50  | 1.  Surrounding the topics          | Federico Goodsaid     |
| pm    |     discussed so far                |                       |
|       |                                     | Leming Shi            |
| (1.5  | 2.  Terms for "Early Access" to     |                       |
| hrs)  |     MAQC data sets                  | Gaspar Taroncher      |
|       |                                     |                       |
|       | 3.  Conf. presentations (IBC Chips  |                       |
|       |     to Hits, *etc*.)                |                       |
|       |                                     |                       |
|       | 4.  Publication cost of             |                       |
|       |     supplemental issue              |                       |
|       |                                     |                       |
|       | 5.  Additional discussion items     |                       |
+-------+-------------------------------------+-----------------------+
| 5:20  | Overview of updated manuscript      | Leming Shi            |
| pm    | proposals                           |                       |
+-------+-------------------------------------+-----------------------+
| 5:30  | MS-3: "Main" manuscript             | Uwe Scherf            |
| pm    |                                     |                       |
+-------+-------------------------------------+-----------------------+
| 6:00  | Adjourn                             |                       |
| pm    |                                     |                       |
+-------+-------------------------------------+-----------------------+

+-------+-------------------------------------+-----------------------+
| *     |                                     |                       |
| *[Day |                                     |                       |
| Two:  |                                     |                       |
| Satu  |                                     |                       |
| rday, |                                     |                       |
| Feb   |                                     |                       |
| ruary |                                     |                       |
| 4,    |                                     |                       |
| 2006  |                                     |                       |
| ]{.ma |                                     |                       |
| rk}** |                                     |                       |
|       |                                     |                       |
| C     |                                     |                       |
| hair: |                                     |                       |
| Weida |                                     |                       |
| Tong  |                                     |                       |
| (FDA/ |                                     |                       |
| NCTR) |                                     |                       |
+-------+-------------------------------------+-----------------------+
| 8:00  | Breakfast                           |                       |
| am    |                                     |                       |
+-------+-------------------------------------+-----------------------+
| 9:00  | Chair's remarks                     | Weida Tong            |
| am    |                                     |                       |
+-------+-------------------------------------+-----------------------+
| 9:05  | *Nature Biotechnology*'s plan for   | Gaspar Taroncher      |
| am    | supplemental issue                  |                       |
+-------+-------------------------------------+-----------------------+
| **Edi |                                     |                       |
| toria |                                     |                       |
| l/Com |                                     |                       |
| menta |                                     |                       |
| ry/Pe |                                     |                       |
| rspec |                                     |                       |
| tive: |                                     |                       |
| MS-0, |                                     |                       |
| MS-1, |                                     |                       |
| M     |                                     |                       |
| S-1A, |                                     |                       |
| MS-2, |                                     |                       |
| MS    |                                     |                       |
| -2A** |                                     |                       |
+-------+-------------------------------------+-----------------------+
| > No  | MS-0: Editorial                     | *Nature               |
| > Pre |                                     | Biotechnology*        |
| senta |                                     |                       |
| tions |                                     |                       |
+-------+-------------------------------------+-----------------------+
|       | MS-1: Pharmacogenomics and the U.S. | Janet Woodcock and    |
|       | FDA's Critical Path Initiative      | Dan Casciano          |
+-------+-------------------------------------+-----------------------+
|       | *MS-1A: Data quality in genomics    | *Ron Davis and Hanlee |
|       | (invited)*                          | Ji*                   |
+-------+-------------------------------------+-----------------------+
|       | MS-2: U.S. FDA's VGDS and IPRG      | Felix Frueh and       |
|       |                                     | Federico Goodsaid     |
+-------+-------------------------------------+-----------------------+
| 9:15  | *MS-2A: U.S. EPA efforts to develop | *David Dix*           |
| am    | a framework for the use of genomics |                       |
|       | data in regulatory and risk         |                       |
|       | assessment applications (proposed)* |                       |
+-------+-------------------------------------+-----------------------+
| **Res |                                     |                       |
| earch |                                     |                       |
| Arti  |                                     |                       |
| cles: |                                     |                       |
| MS-3  |                                     |                       |
| to    |                                     |                       |
| MS    |                                     |                       |
| -14** |                                     |                       |
+-------+-------------------------------------+-----------------------+
| 9:25  | MS-5: Sequence mapping              | Damir Herman          |
| am    |                                     |                       |
+-------+-------------------------------------+-----------------------+
| 9:40  | MS-6: Impact of normalization and   | Leming Shi            |
| am    | gene selection                      |                       |
+-------+-------------------------------------+-----------------------+
| 9:55  | MS-7: Alternative technologies      | Federico Goodsaid     |
| am    |                                     |                       |
+-------+-------------------------------------+-----------------------+
| 10:10 | MS-8: Titration mixtures            | Rich Shippy           |
| am    |                                     |                       |
+-------+-------------------------------------+-----------------------+
| 10:25 | MS-9: Modeling technical variation  | Walter Liggett        |
| am    |                                     |                       |
+-------+-------------------------------------+-----------------------+
| 10:40 | **Coffee break**                    |                       |
| am    |                                     |                       |
+-------+-------------------------------------+-----------------------+
| 11:00 | MS-10: Cross-hybridization          | Zoltan Szallasi and   |
| am    |                                     | Rick Jensen           |
+-------+-------------------------------------+-----------------------+
| 11:15 | MS-11: One-color versus two-color   | Tucker Patterson      |
| am    |                                     |                       |
+-------+-------------------------------------+-----------------------+
| 11:30 | MS-12: Spike-ins for array quality  | Weida Tong            |
| am    | assessment                          |                       |
+-------+-------------------------------------+-----------------------+
| 11:45 | MS-4: Applications of MAQC RNA      | TBD                   |
| am    | samples                             |                       |
+-------+-------------------------------------+-----------------------+
| 12:00 | *MS-13: Validation of               | *Lei Guo*             |
| pm    | MAQC-recommended microarray data    |                       |
|       | analysis methods using real-world   | *David Dix*           |
|       | toxicogenomics data sets            |                       |
|       | (proposed)*                         | *Leming Shi*          |
+-------+-------------------------------------+-----------------------+
| 12:15 | *MS-14: Reproducibility analysis    | *Sheng Zhong*         |
| pm    | for microarray experiments          |                       |
|       | (proposed)*                         |                       |
+-------+-------------------------------------+-----------------------+
| 12:30 | **Lunch**                           |                       |
| pm    |                                     |                       |
+-------+-------------------------------------+-----------------------+
| 1:30  | 1.  Resolving overlaps              | Leming Shi            |
| pm    |                                     |                       |
|       | 2.  Filling gaps                    | Gaspar Taroncher      |
| (2    |                                     |                       |
| hrs   | 3.  Task assignments                | []{.mark}             |
| 20    |                                     |                       |
| min.) | 4.  Co-authorship                   | ***[Ma                |
|       |                                     | r-15-2006]{.mark}***: |
|       | 5.  Publication cost                | 1^st^ draft of full   |
|       |                                     | manuscripts due.      |
+-------+-------------------------------------+-----------------------+
| 3:50  | Concluding remarks                  | Leming Shi            |
| pm    |                                     |                       |
+-------+-------------------------------------+-----------------------+
| 4:00  | Adjourn                             |                       |
| pm    |                                     |                       |
+-------+-------------------------------------+-----------------------+

[Many thanks to Dr. Rick Jensen and his staff for organizing the MAQC-4
project meeting.]{.mark}

**Location**:

The meeting will be held on February 3-4, 2006 at the UMASS Boston
Campus (Room S3-127 in the Science Building).

Dear colleague,

You are invited to participate in the MAQC-4 "Data Analysis Jamboree"
that will be held on Friday and Saturday, February 3-4, 2006 on the
University of Massachusetts Boston Campus
([www.umb.edu](http://www.umb.edu/)).  Attendance is by invitation only
and will be restricted to members of the MAQC data analysis groups and
representatives of the participating platforms. In this 2 day workshop
we should have ample time to present our (near) final analysis results
of the MAQC data; sort out differences in methods, assumptions, and
results; and work on the manuscripts for publication.

The workshop will run from 9:00-6:00 on Friday February 3 and 9:00-4:00
on Saturday February 4 in a new, large Computer Laboratory with 22
hardwired workstations and ample room for 20 more laptops with wireless
internet access and full audio visual capabilities for presentations.
(Room S3-127 in the Science building on the UMASS Boston Campus.)
Breakfast, Coffee, Lunch and Afternoon Snacks will be provided both
days.

The UMASS Boston campus is easily accessed by public transportation via
the Red Line subway ("T").  It has its own stop on the Red Line, three
stops south of South Station (the main train station) and is about 30
minutes by public transportation from the main Boston Logan Airport. 
From the UMASS/JFK "T" stop the free #1 campus shuttle bus runs
continuously for the 5 minute ride to the main campus where the Science
building is located.

Blocks of rooms have been reserved at the nearby Doubletree Bayside
Hotel (15 minute walk, 5 minutes by the continuously running #1 campus
shuttle bus) as well as the more upscale Seaport Hotel (25 minutes from
UMB by subway). Please call the Hotels directly for reservations for the
UMASS Boston MAQC conference.

**Doubletree Club Hotel Boston Bayside**

240 Mt. Vernon Street

617-822-3600

Rooms on hold for February 2^nd^, 3^rd^, 4^th^

20 rooms each night on hold until January 25^th^

Rate: \$109/night

**Seaport Hotel**

1 Seaport Lane

617-385-5000

Rooms on hold for February 2^nd^, 3^rd^, 4^th^

10 rooms each night on hold until January 18^th^

Rate: \$159/night

(The Seaport Hotel rooms are at a substantial discount.)

UMASS Boston is also about 20 minutes from the downtown Boston Hotels
and 25 and 30 minutes from the Cambridge Hotels near MIT and Harvard on
the Red Line subway.

Please confirm your plans to participate by return e-mail (so I can be
sure there is plenty of coffee and food).

Also let me know if you have any questions or difficulties getting room
reservations.

\-\-- Rick

\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--

Roderick V. Jensen\
Alton Brann Distinguished Professor of Physics, Biology, and
Mathematics\
and\
Director of the Center for Environmental Health, Science, and
Technology\
University of Massachusetts Boston\
\
Department of Physics\
University of Massachusetts Boston\
100 Morrissey Blvd\
Boston, MA 02125\
\
Office: 617-287-6032\
Dept:   617-287-6050\
FAX:    617-287-6053

www.biotech.umb.edu