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**UNITED STATES ENVIRONMENTAL PROTECTION AGENCY**

**WASHINGTON, D.C. 20460**

**OFFICE OF PREVENTION, PESTICIDES AND TOXIC SUBSTANCES**

April 18, 2007

**MEMORANDUM**

**SUBJECT:** Review of Fumigants Group Incident Reports

DP Barcode D314383, D306860, D337561, D337561, D337778, D337567,
Chemical #053201, 053203, 029001, 029004, 039003, 039002, 035602, 035607

**FROM:** Monica Hawkins, M.P.H., Environmental Health Scientist

Chemistry and Exposure Branch

Health Effects Division (7509P)

Hans Allender, Ph.D., Statistician

Chemistry and Exposure Branch

Health Effects Division (7509P)

**THRU:** David J. Miller, Chief

Chemistry and Exposure Branch

Health Effects Division (7509P)

**TO:** Steven Weiss

Andrea Carone

Cathryn O'Connell

Veronique LaCapra

Nathan Mottl

Chemical Review Manages

Special Review and Re-registration Division (7508 P)

**BACKGROUND**

The scope of this report encompasses a group of six Fumigants. Their
names and PC Codes are:

> A\) Methyl Bromide; PC Codes 053201 and 053203
>
> B\) 1,3-Dichloropropene (Telone); PC Codes 029001 and 029004

C)  Metam-Sodium; PC Code 039003

D)  Metam-Potassium; PC Code 039002

E)  Dazomet; PC Codes 035602 and 035607

F)  Chloropicrin; PC Codes 081501 and 081502.

The reader will find a lettered section of this report dedicated to each
compound. For each chemical, the following databases have been consulted
to find the poisoning incident data on each active ingredient.

**1)** **[Poison Control Centers]{.underline}** - as the result of a
data purchase by EPA, OPP received Poison Control Center data covering
the years 1993 through 2005 for all pesticides. Most of the national
Poison Control Centers (PCCs) participate in a national data collection
system, the Toxic Exposure Surveillance System (TESS) which obtains data
from about 65-70 centers at hospital and universities. PCCs provide
telephone consultation for individuals and health care providers on
suspected poisonings, involving drugs, household products, pesticides,
etc.

**2)** **[OPP Incident Data System (IDS]{.underline})** - reports of
incidents from various sources, including registrants, other federal and
state health and environmental agencies and individual consumers,
submitted to OPP since 1992. Reports submitted to the Incident Data
System represent anecdotal reports or allegations only, unless otherwise
stated. Typically, no conclusions can be drawn implicating the pesticide
as a cause of any of the reported health effects. Nevertheless,
sometimes with enough cases and/or documentation risk mitigation
measures may be suggested

**3)** **[California Department of Pesticide Regulation]{.underline}** -
California has collected uniform data on suspected pesticide poisonings
since 1982. Physicians are required, by statute, to report to their
local health officer all occurrences of illness suspected of being
related to exposure to pesticides. The majority of the incidents involve
workers. Information on exposure (worker activity), type of illness
(systemic, eye, skin, eye/skin and respiratory), likelihood of a causal
relationship, and number of days off work and in the hospital are
provided.

**4)** **[National Institute of Occupational Safety and Health's
Sentinel Event Notification System for Occupational Risks (NIOSH
SENSOR)]{.underline}** performs standardized surveillance in nine states
from 1998 through 2003. States included in this reporting system are
Arizona, California, Florida, Louisiana, Michigan, New York, Oregon,
Texas, and Washington. Reporting is very uneven from state to state
because of the varying cooperation from different sources of reporting
(e.g., workers compensation, Poison Control Centers, emergency
departments and hospitals, enforcement investigations, private
physicians, etc.). Therefore, these reports should not be characterized
as estimating the total magnitude of poisoning. The focus is on
occupationally-related cases not residential or other non-occupational
exposures. However, the information collected on each case is
standardized and categorized according to the certainty of the
information collected and the severity of the case.

This review offers a collection of incidents for each fumigant; for each
particular fumigant the report is divided in 4 sections:

1- Cases reported in the Poison Control Center Database from 1993 to
2005.

> 2 - Cases reported in the Incident Data System (Attachment 1) from
> 2001 to the present;

3 - Cases reported in the California Department of Pesticide Regulation
from 1982 to 2004 or by specified period.

> 4 - Cases reported in the NIOSH system from 1998 to 2003.

**A) [Methyl Bromide PC Codes 053201 and 053203]{.underline}**

**1.A Number range CHAPTER[Poison Control Center Data - 1993 through
2005 for Methyl Bromide, PC Code 053201 and 053203]{.underline}**

This section discusses results from the Poison Control Center's Toxic
Exposure Surveillance System (TESS) from the years 1993 through 2005 and
reflects data collected for occupational, non-occupational, and children
class. The children class is five years of age or less (this definition
includes children about to become six years old, or up to 72 month old).
Cases involving exposures to multiple products and cases with unrelated
medical outcome are excluded. Also excluded are intentional exposures.
The tables included in this section transmit acute pesticide poisoning
incidence resulting from exposure to Methyl Bromide.

The following tables evaluate the frequency of poisoning incidents for
Methyl Bromide with the composite of [all]{.underline} pesticides for
which the PCC received a non-excluded incident report. The frequency of
events is reported by health effect severity category (all symptoms,
moderate, and major) and by level of health care received. A comparative
ratio provides a simple measure of the relative frequency of reported
health effects by severity category. Knowledge of the ratios of symptoms
for a single chemical (or a group of chemicals) provides a relative
measure of the public health impact of the acute pesticide events. In
addition, a Likelihood Ratio test shows whether the compound under study
is significantly different from the average of all other pesticides. An
(**s**) indicates the proportions are significantly different.

For a detailed explanation of the tables, see Attachment 2.

**Table 1-A**. **Relative Frequency of Acute Poisoning Incidents by
Symptom Severity: [Occupational Cases]{.underline}**

+-------------------+-------+-------+-------+-------+-------+-------+
|                   | **Sev |       |       | **To  | **H   |       |
|                   | erity |       |       | tal** | ealth |       |
|                   | of    |       |       |       | c     |       |
|                   | outc  |       |       | *     | are** |       |
|                   | ome** |       |       | *expo |       |       |
|                   |       |       |       | sed** | **    |       |
|                   | **(ou |       |       |       | provi |       |
|                   | tcome |       |       |       | ded** |       |
|                   | det   |       |       |       |       |       |
|                   | ermin |       |       |       |       |       |
|                   | ed)** |       |       |       |       |       |
+===================+=======+=======+=======+=======+=======+=======+
| **Denominator     | *     |       |       | *     | *     |       |
| numbers**         | *60** |       |       | *77** | *54** |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Measures**      | **SYM | **MOD | **MAJ | **HCF | *     | **ICU |
|                   | ^1^** | ^2^** | ^3^** | ^4^** | *HOSP | ^6^** |
|                   |       |       |       |       | ^5^** |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Numerator       | *     | *     | **1** | *     | **5** | **2** |
| numbers**         | *56** | *21** |       | *54** |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Methyl Bromide  | **93. | **35. | **1.  | **70. | **9.  | **3.  |
| percents**        | 33%** | 00%** | 67%** | 13%** | 26%** | 70%** |
+-------------------+-------+-------+-------+-------+-------+-------+
| **All Pesticides  | **86. | **20. | **0.  | **42. | **7.  | **2.  |
| percents**        | 25%** | 89%** | 81%** | 94%** | 00%** | 83%** |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Ratio of Methyl | **1   | *     | **2   | *     | **1   | **1   |
| Bromide/All       | .08** | *1.68 | .06** | *1.63 | .32** | .31** |
| pesticides**      |       | (S)** |       | (S)** |       |       |
|                   | **P   |       | **P = |       | **P = | **P   |
|                   | =0    | **P = | 0     | **P = | 0     | =0    |
|                   | .11** | 0     | .45** | 0.0** | .51** | .70** |
|                   |       | .00** |       |       |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+

1\) percent with ANY symptom in relation to the total of cases followed;
2) percent with moderate symptoms in relation to the total of cases
followed; 3) percent with major or fatal outcome in relation to the
total of cases followed; 4) percent of case seen in a Health Care
Facility (HCF) in relation to total exposures; 5) percent of cases seen
in a Hospital in relation to cases seen in a HCF; 6) percent of cases
taken to an Intensive Care Unit (ICU) in relation to cases seen in a
HCF.

**Table 2-A**. **Relative Frequency of Acute Poisoning Incidents by
Symptom Severity: [Non-Occupational Cases]{.underline}**

+-------------------+-------+-------+-------+-------+-------+-------+
|                   | **Sev |       |       | **To  | **H   |       |
|                   | erity |       |       | tal** | ealth |       |
|                   | of    |       |       |       | c     |       |
|                   | outc  |       |       | *     | are** |       |
|                   | ome** |       |       | *expo |       |       |
|                   |       |       |       | sed** | **    |       |
|                   | **(ou |       |       |       | provi |       |
|                   | tcome |       |       |       | ded** |       |
|                   | det   |       |       |       |       |       |
|                   | ermin |       |       |       |       |       |
|                   | ed)** |       |       |       |       |       |
+===================+=======+=======+=======+=======+=======+=======+
| **Denominator     | *     |       |       | *     | *     |       |
| numbers**         | *47** |       |       | *77** | *21** |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Measures**      | **SYM | **MOD | **MAJ | **HCF | *     | **ICU |
|                   | ^1^** | ^2^** | ^3^** | ^4^** | *HOSP | ^6^** |
|                   |       |       |       |       | ^5^** |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Numerator       | *     | **4** | **0** | *     | **3** | **0** |
| numbers**         | *34** |       |       | *21** |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Methyl Bromide  | **72. | **8.  | **0.  | **27. | **14. | **0.  |
| percents**        | 34%** | 51%** | 00%** | 27%** | 28%** | 00%** |
+-------------------+-------+-------+-------+-------+-------+-------+
| **All Pesticides  | **64. | **10. | **0.  | **15. | **7.  | **3.  |
| percents**        | 72%** | 61%** | 45%** | 45%** | 94%** | 02%** |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Ratio of Methyl | **1   | **0   | **0   | *     | **1   | **0   |
| Bromide/All       | .12** | .80** | .00** | *1.77 | .80** | .00** |
| pesticides**      |       |       |       | (S)** |       |       |
|                   | **P   | **P = | **P = |       | **P = | **P   |
|                   | =0    | 0     | 0     | **P = | 0     | =0    |
|                   | .27** | .64** | .53** | 0     | .28** | .42** |
|                   |       |       |       | .00** |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+

1\) percent with ANY symptom in relation to the total of cases followed;
2) percent with moderate symptoms in relation to the total of cases
followed; 3) percent with major or fatal outcome in relation to the
total of cases followed; 4) percent of case seen in a Health Care
Facility (HCF) in relation to total exposures; 5) percent of cases seen
in a Hospital in relation to cases seen in a HCF; 6) percent of cases
taken to an Intensive Care Unit (ICU) in relation to cases seen in a
HCF.

**Table 3-A**. **Relative Frequency of Acute Poisoning Incidents by
Symptom Severity: [Children Cases]{.underline}**

+-------------------+-------+-------+-------+-------+-------+-------+
|                   | **Sev |       |       | **To  | **H   |       |
|                   | erity |       |       | tal** | ealth |       |
|                   | of    |       |       |       | c     |       |
|                   | outc  |       |       | *     | are** |       |
|                   | ome** |       |       | *expo |       |       |
|                   |       |       |       | sed** | **    |       |
|                   | **(ou |       |       |       | provi |       |
|                   | tcome |       |       |       | ded** |       |
|                   | det   |       |       |       |       |       |
|                   | ermin |       |       |       |       |       |
|                   | ed)** |       |       |       |       |       |
+===================+=======+=======+=======+=======+=======+=======+
| **Denominator     | *     |       |       | *     | **4** |       |
| numbers**         | *10** |       |       | *14** |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Measures**      | **SYM | **MOD | **MAJ | **HCF | *     | **ICU |
|                   | ^1^** | ^2^** | ^3^** | ^4^** | *HOSP | ^6^** |
|                   |       |       |       |       | ^5^** |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Numerator       | **4** | **1** | **0** | **4** | **0** | **0** |
| numbers**         |       |       |       |       |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Methyl Bromide  | **40. | **10. | **0.  | **28. | **0.  | **0.  |
| percents**        | 00%** | 00%** | 00%** | 57%** | 00%** | 00%** |
+-------------------+-------+-------+-------+-------+-------+-------+
| **All Pesticides  | **23. | **1.  | **0.  | **14. | **4.  | **1.  |
| percents**        | 16%** | 48%** | 13%** | 80%** | 48%** | 41%** |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Ratio of Methyl | **1   | *     | **0   | **1   | **0   | **0   |
| Bromide /All      | .73** | *6.76 | .00** | .93** | .00** | .00** |
| pesticides**      |       | (S)** |       |       |       |       |
|                   | **P   |       | **P = | **P = | **P = | **P   |
|                   | =0    | **P = | 0     | 0     | 0     | =0    |
|                   | .20** | 0     | .90** | .14** | .65** | .81** |
|                   |       | .03** |       |       |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+

1\) percent with ANY symptom in relation to the total of cases followed;
2) percent with moderate symptoms in relation to the total of cases
followed; 3) percent with major or fatal outcome in relation to the
total of cases followed; 4) percent of case seen in a Health Care
Facility (HCF) in relation to total exposures; 5) percent of cases seen
in a Hospital in relation to cases seen in a HCF; 6) percent of cases
taken to an Intensive Care Unit (ICU) in relation to cases seen in a
HCF.

**Table 4-A**. **Relative Frequency of Acute Poisoning Incidents by
Symptom Severity: [Combination of All Cases Regardless
Class]{.underline}**

+-------------------+-------+-------+-------+-------+-------+-------+
|                   | **Sev |       |       | **To  | **H   |       |
|                   | erity |       |       | tal** | ealth |       |
|                   | of    |       |       |       | c     |       |
|                   | outc  |       |       | *     | are** |       |
|                   | ome** |       |       | *expo |       |       |
|                   |       |       |       | sed** | **    |       |
|                   | **(ou |       |       |       | provi |       |
|                   | tcome |       |       |       | ded** |       |
|                   | det   |       |       |       |       |       |
|                   | ermin |       |       |       |       |       |
|                   | ed)** |       |       |       |       |       |
+===================+=======+=======+=======+=======+=======+=======+
| **Denominator     | **    |       |       | **    | *     |       |
| numbers**         | 117** |       |       | 168** | *79** |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Measures**      | **SYM | **MOD | **MAJ | **HCF | *     | **ICU |
|                   | ^1^** | ^2^** | ^3^** | ^4^** | *HOSP | ^6^** |
|                   |       |       |       |       | ^5^** |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Numerator       | *     | *     | **1** | *     | **8** | **2** |
| numbers**         | *94** | *26** |       | *79** |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Methyl Bromide  | **80. | **22. | **0.  | **47. | **10. | **2.  |
| percents**        | 34%** | 22%** | 85%** | 02%** | 13%** | 53%** |
+-------------------+-------+-------+-------+-------+-------+-------+
| **All Pesticides  | **42. | **6.  | **0.  | **16. | **6.  | **2.  |
| percents**        | 69%** | 02%** | 29%** | 01%** | 05%** | 16%** |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Ratio of Methyl | *     | *     | **2   | *     | **1   | **1   |
| Bromide/All       | *1.88 | *3.69 | .95** | *2.94 | .67** | .17** |
| pesticides**      | (S)** | (S)** |       | (S)** |       |       |
|                   |       |       | **P = |       | **P = | **P   |
|                   | **P   | **P = | 0     | **P = | 0     | =0    |
|                   | =0    | 0     | .26** | 0     | .13** | .82** |
|                   | .00** | .00** |       | .00** |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+

1\) percent with ANY symptom in relation to the total of cases followed;
2) percent with moderate symptoms in relation to the total of cases
followed; 3) percent with major or fatal outcome in relation to the
total of cases followed; 4) percent of case seen in a Health Care
Facility (HCF) in relation to total exposures; 5) percent of cases seen
in a Hospital in relation to cases seen in a HCF; 6) percent of cases
taken to an Intensive Care Unit (ICU) in relation to cases seen in a
HCF.

Table 5-A provides a summary by year, and Figure 1-A shows a graphic
summary for yearly exposures cases, symptomatic cases, and cases seen in
a health care facility.

**Table 5-A Methyl Bromide Summary of Cases by Year**

  ----------- ------------- -------------- ----------- -------------- -------------- ----------- -------------- -----------
  **Year**    **Symptom**   **Moderate**   **Major**   **Cases**      **Total**      **HCF**     **Hospital**   **ICU**

  ** **       **Cases**     **Cases**      **Cases**   **Followed**   **Exposure**   **Cases**   **Cases**      **Cases**

  **1993**    **15**        **4**          **0**       **16**         **22**         **11**      **2**          **0**

  **1994**    **6**         **1**          **0**       **7**          **10**         **5**       **1**          **0**

  **1995**    **16**        **5**          **0**       **18**         **20**         **12**      **1**          **0**

  **1996**    **16**        **1**          **0**       **21**         **28**         **6**       **0**          **0**

  **1997**    **4**         **2**          **0**       **11**         **15**         **8**       **0**          **0**

  **1998**    **7**         **5**          **0**       **11**         **20**         **5**       **0**          **0**

  **1999**    **3**         **0**          **0**       **3**          **8**          **5**       **0**          **0**

  **2000**    **5**         **1**          **0**       **5**          **6**          **4**       **1**          **0**

  **2001**    **3**         **1**          **0**       **4**          **11**         **2**       **0**          **0**

  **2002**    **3**         **1**          **0**       **4**          **4**          **4**       **1**          **1**

  **2003**    **1**         **1**          **0**       **2**          **5**          **2**       **1**          **0**

  **2004**    **11**        **1**          **0**       **11**         **13**         **10**      **0**          **0**

  **2005**    **4**         **3**          **1**       **4**          **6**          **5**       **1**          **1**

  **Total**   **94**        **26**         **1**       **117**        **168**        **79**      **8**          **2**
  ----------- ------------- -------------- ----------- -------------- -------------- ----------- -------------- -----------

**Figure 1-A** Total exposure, symptomatic cases, and cases sent to HCF
by year.

![](media/image2.wmf){width="6.49375in" height="4.829861111111111in"}

**[Analysis of Results]{.underline}**

For the occupational class, all percentages of Methyl Bromide are higher
than the percentages for the composite. Methyl Bromide produces a
significant higher number of moderate cases and sends a significant
higher number of cases to a Health Care Facility (HCF). These results
may indicate the need to stress measurements for worker protection or
more training of workers on how to handle Methyl Bromide safely. For the
non-occupational class, Methyl Bromide sends a significant higher number
of cases to the HCF. For the children class there is not much exposure,
only 14 cases in 13 years of data collected. Effects of Methyl Bromide
on the entire population are well above the composite average in all
measurements and significantly higher in: symptoms produced moderated
symptoms, and cases seen in a HCF.

An irregular downward trend in total exposure, symptomatic cases, and
cases seen in a HCF is apparent for the 13 year-span of data collected
on Methyl Bromide. Calculations generate an average of 13 exposures per
year, 7 symptomatic cases per year, and 7 cases per year seen in a heath
care facility. The cluster of years 93, 95, 96, 97, and 98 has exposures
rates well above the average and then after 1998 the graphic shows lower
percentage of exposures.

**2. A** [**Methyl Bromide Incidents OPP Incident Data System (IDS)**
**(2001- present)**]{.underline}

A total of 25 cases were reported from 2001 to present dayon Methyl
Bromide. For a detailed description of each case see **Attachment 1. A**

**3. A [Methyl Bromide California Pesticide Illness Surveillance Program
Data 2000-2004]{.underline}**

Detailed descriptions of 72 cases submitted to the California Pesticide
Illness Surveillance Program (2002-2004) were reviewed. In 8 of these
cases, methyl bromide was used alone or was judged to be responsible for
the health effects. Only cases with a definite, probable or possible
relationship were reviewed.

In the first case, an import company employee unloaded a container of
straw handbags that was fumigated with the product in the Philippines
prior to shipment. The employee reported dizziness, headache, chest pain
and tightness, skin irritation, blurred vision, and itchy eyes and was
treated by a physician. The employee was off for 2 days from work due to
these symptoms. Another container was tested and its contamination
levels were high.

In the second case, an applicator reported itchy feet and painful
blisters on the top of both of his feet on the second day that tree
holes were treated with product. The man was exposed to the product
while tamping down the soil around the probe hole. He was off from work
for 2 days due to his symptoms.

In the third case, a worker fumigated a sea van. Later, he pulled on the
rubber hose to remove the attached metal tubing from the sea van. The
metal tube snapped backward and broke his safety glasses left lens. The
man reported an irritated left eye and blurred vision.

In the fourth case, a field worker went to the edge of the winery
property and noticed an odor. He tested the grapes and later reported
dizziness, lightheadedness, headache, nausea, vomiting, fatigue, burning
eyes, blurred vision, and lung irritation.

In the fifth case, an applicator reported red skin on his left foot on
the first day after performing tree-hole fumigations. Eight days later,
the man reported itchy skin and on the tenth day a red, burning, and
swollen left foot. His symptoms continued to get worse until he was
treated by a physician ten days later.

In the sixth case, an applicator failed to confirm that the valve was
closed while replacing an empty cylinder on a fumigation chamber. As he
loosened the cap, gas escaped from the valve that touched his arms and
went under his face shield and into his face. The man reported a
headache and nausea and was treated by a physician. The physician noted
a light chemical injury on the arm and face during the examination. The
man was off for 2 days from work.

In the seventh case, a shipping lines employee opened a methyl bromide
placarded container. He entered the container to replace 2 boxes that
had fallen. The man smelled an odor and felt faint.

In the eighth case, an applicator performed tree-hole fumigations with
poorly maintained equipment. The hose broke twice in 2 days and the
product got into his face and eyes. The man reported skin and eye
irritation, nausea, vomiting, severe abdominal cramps, severe dizziness,
headache, body aches, and loss of balance that were still present 3
months after he was exposed. He was hospitalized for 11 days.

**4. A [Methyl Bromide NIOSH SENSOR]{.underline}**

Out of 5,899 reported cases from 1998 to 2003, there are thirty-three
cases reported in the SENSOR database involving Methyl Bromide.
Individuals exposed included thirty males and three females. Twenty-five
cases were reported in California, two in Florida, four in Texas and 2
in Washington State. The cases reported produced a variety of symptoms
that are classified as

1.  [Respiratory symptoms]{.underline}, eighteen cases including,
    cyanosis, hyperventilation/ tachypnea, pleuritic chest pain,
    wheezing, etc.

2.  [Dermal symptoms]{.underline}, sixteen cases reported including
    bullae (blisters), burns, edema, swelling, erythema flushing, rash,
    skin irritation and pain

3.  [Gastro intestinal]{.underline}, fifteen cases reported, with
    symptoms described as abdominal pain, cramping and vomiting.

4.  [Ocular symptoms]{.underline}, twelve cases, including pain eye
    irritation, inflammation, and conjunctivitis

5.  [Cardio vascular symptoms,]{.underline} ten cases counting cardiac
    arrest, tachycardia, hypotension, and hypertension.

6.  [Renal symptoms,]{.underline} two cases of polyuria (frequent
    passing of urine) and proteinuria (protein in the urine)

7.  [Nervous-sensory symptoms,]{.underline} two cases including comma,
    confusion, seizure, fasciculation (localized contraction of
    muscles), and

8.  [Miscellaneous symptoms,]{.underline} seven cases accounting for
    acidosis, alkalosis, hyperthermia/fever.

Symptoms are not mutually exclusive; a patient may have many symptoms.

**B) [1, 3-Dichloropropene (Telone) PC Codes 029001 and
029004]{.underline}**

**1.B Number range CHAPTER[Poison Control Center Data - 1993 through
2005 for 1,3-Dichloropropene (Telone); PC Codes 029001 and
029004]{.underline}**

This section discusses results from the Poison Control Center's Toxic
Exposure Surveillance System (TESS) from the years 1993 through 2005 and
reflects data collected for occupational, non-occupational, and children
class. The tables included in this section transmit acute pesticide
poisoning incidence resulting from exposure to 1, 3-Dichloropropene.

The following tables evaluate the frequency of poisoning incidents for
1, 3-Dichloropropene with the composite of [all]{.underline} pesticides
for which the PCC received a non-excluded incident report.

For a detailed explanation of the tables, see Attachment 2.

**Table 1-B**. **Relative Frequency of Acute Poisoning Incidents by
Symptom Severity: [Occupational Cases]{.underline}**

+-------------------+------+-------+-------+-------+-------+-------+
|                   | **   |       |       | **To  | **H   |       |
|                   | Seve |       |       | tal** | ealth |       |
|                   | rity |       |       |       | c     |       |
|                   | of   |       |       | *     | are** |       |
|                   | o    |       |       | *expo |       |       |
|                   | utco |       |       | sed** | **    |       |
|                   | me** |       |       |       | Provi |       |
|                   |      |       |       |       | ded** |       |
|                   | **   |       |       |       |       |       |
|                   | (out |       |       |       |       |       |
|                   | come |       |       |       |       |       |
|                   | d    |       |       |       |       |       |
|                   | eter |       |       |       |       |       |
|                   | mine |       |       |       |       |       |
|                   | d)** |       |       |       |       |       |
+===================+======+=======+=======+=======+=======+=======+
| **Denominator     | **   |       |       | *     | *     |       |
| numbers**         | 14** |       |       | *24** | *16** |       |
+-------------------+------+-------+-------+-------+-------+-------+
| **Measures**      | **   | **MOD | **MAJ | **HCF | *     | **ICU |
|                   | SYM^ | ^2^** | ^3^** | ^4^** | *HOSP | ^6^** |
|                   | 1^** |       |       |       | ^5^** |       |
+-------------------+------+-------+-------+-------+-------+-------+
| **Numerator       | **   | **3** | **0** | *     | **1** | **0** |
| numbers**         | 11** |       |       | *16** |       |       |
+-------------------+------+-------+-------+-------+-------+-------+
| **1,              | **   | **21. | **0.  | **66. | **6.  | **0.  |
| 3-Dichloropropene | 78.5 | 43%** | 00%** | 67%** | 25%** | 00%** |
| percents**        | 7%** |       |       |       |       |       |
+-------------------+------+-------+-------+-------+-------+-------+
| **All Pesticides  | **   | **20. | **0.  | **42. | **7.  | **2.  |
| percents**        | 86.2 | 89%** | 81%** | 94%** | 00%** | 83%** |
|                   | 5%** |       |       |       |       |       |
+-------------------+------+-------+-------+-------+-------+-------+
| **Ratio of 1,     | **0. | **1   | **0   | *     | **0   | **0   |
| 3                 | 91** | .03** | .00** | *1.55 | .89** | .00** |
| -Dichloro-propene |      |       |       | (S)** |       |       |
| /All pesticides** | **P  | **P = | **P = |       | **P = | **P   |
|                   | =0.  | 0     | 0     | **P = | 0     | =0    |
|                   | 45** | .96** | .73** | 0     | .90** | .49** |
|                   |      |       |       | .02** |       |       |
+-------------------+------+-------+-------+-------+-------+-------+

1\) percent with ANY symptom in relation to the total of cases followed;
2) percent with moderate symptoms in relation to the total of cases
followed; 3) percent with major or fatal outcome in relation to the
total of cases followed; 4) percent of case seen in a Health Care
Facility (HCF) in relation to total exposures; 5) percent of cases seen
in a Hospital in relation to cases seen in a HCF; 6) percent of cases
taken to an Intensive Care Unit (ICU) in relation to cases seen in a
HCF.

**Table 2-B**. **Relative Frequency of Acute Poisoning Incidents by
Symptom Severity: [Non-Occupational Cases]{.underline}**

+-------------------+-------+-------+-------+-------+-------+-------+
|                   | **Sev |       |       | **To  | **H   |       |
|                   | erity |       |       | tal** | ealth |       |
|                   | of    |       |       |       | c     |       |
|                   | outc  |       |       | *     | are** |       |
|                   | ome** |       |       | *expo |       |       |
|                   |       |       |       | sed** | **    |       |
|                   | **(ou |       |       |       | provi |       |
|                   | tcome |       |       |       | ded** |       |
|                   | det   |       |       |       |       |       |
|                   | ermin |       |       |       |       |       |
|                   | ed)** |       |       |       |       |       |
+===================+=======+=======+=======+=======+=======+=======+
| **Denominator     | *     |       |       | *     | *     |       |
| numbers**         | *24** |       |       | *40** | *16** |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Measures**      | **SYM | **MOD | **MAJ | **HCF | *     | **ICU |
|                   | ^1^** | ^2^** | ^3^** | ^4^** | *HOSP | ^6^** |
|                   |       |       |       |       | ^5^** |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Numerator       | *     | *     | **1** | *     | **0** | **0** |
| numbers**         | *23** | *11** |       | *16** |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **1,              | **95. | **45. | **4.  | **40. | **0.  | **0.  |
| 3-Dichloropropene | 83%** | 83%** | 17%** | 00%** | 00%** | 00%** |
| percents**        |       |       |       |       |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **All Pesticides  | **64. | **10. | **0.  | **15. | **7.  | **3.  |
| percents**        | 72%** | 61%** | 45%** | 45%** | 94%** | 02%** |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Ratio of** **1, | *     | *     | *     | *     | **0   | **0   |
| 3                 | *1.48 | *4.32 | *9.26 | *2.59 | .00** | .00** |
| -Dichloro-propene | (S)** | (S)** | (S)** | (S)** |       |       |
| /All pesticides** |       |       |       |       | **P = | **P   |
|                   | **P   | **P = | **P = | **P = | 0     | =0    |
|                   | =0    | 0     | 0     | 0     | .23** | .48** |
|                   | .00** | .00** | .00** | .00** |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+

1\) percent with ANY symptom in relation to the total of cases followed;
2) percent with moderate symptoms in relation to the total of cases
followed; 3) percent with major or fatal outcome in relation to the
total of cases followed; 4) percent of case seen in a Health Care
Facility (HCF) in relation to total exposures; 5) percent of cases seen
in a Hospital in relation to cases seen in a HCF; 6) percent of cases
taken to an Intensive Care Unit (ICU) in relation to cases seen in a
HCF.

**Table 3-B**. **Relative Frequency of Acute Poisoning Incidents by
Symptom Severity: [Children Cases]{.underline}**

+-------------------+-------+-------+-------+-------+-------+-------+
|                   | **Sev |       |       | **To  | **H   |       |
|                   | erity |       |       | tal** | ealth |       |
|                   | of    |       |       |       | c     |       |
|                   | outc  |       |       | *     | are** |       |
|                   | ome** |       |       | *expo |       |       |
|                   |       |       |       | sed** | **    |       |
|                   | **(ou |       |       |       | provi |       |
|                   | tcome |       |       |       | ded** |       |
|                   | det   |       |       |       |       |       |
|                   | ermin |       |       |       |       |       |
|                   | ed)** |       |       |       |       |       |
+===================+=======+=======+=======+=======+=======+=======+
| **Denominator     | **2** |       |       | **2** | **1** |       |
| numbers**         |       |       |       |       |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Measures**      | **SYM | **MOD | **MAJ | **HCF | *     | **ICU |
|                   | ^1^** | ^2^** | ^3^** | ^4^** | *HOSP | ^6^** |
|                   |       |       |       |       | ^5^** |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Numerator       | **2** | **1** | **0** | **1** | **0** | **0** |
| numbers**         |       |       |       |       |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **1,              | *     | **50. | **0.  | **50. | **0.  | **0.  |
| 3-Dichloropropene | *100. | 00%** | 00%** | 00%** | 00%** | 00%** |
| percents**        | 00%** |       |       |       |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **All Pesticides  | **23. | **1.  | **0.  | **14. | **4.  | **1.  |
| percents**        | 16%** | 48%** | 13%** | 80%** | 48%** | 41%** |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Ratio of 1,     | **4   | **33  | **0.0 | **3.3 | **0.0 | **0.0 |
| 3                 | .32\* | .78\* | 0\*** | 8\*** | 0\*** | 0\*** |
| -Dichloro-propene | (S)** | (S)** |       |       |       |       |
| /All pesticides** |       |       | **P = | **P = | **P = | **P   |
|                   | **P   | **P = | 0     | 0     | 0     | =0    |
|                   | =0    | 0     | .95** | .16** | .74** | .86** |
|                   | .01** | .00** |       |       |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+

**\* Population too small for a reliable statistical test**

1\) percent with ANY symptom in relation to the total of cases followed;
2) percent with moderate symptoms in relation to the total of cases
followed; 3) percent with major or fatal outcome in relation to the
total of cases followed; 4) percent of case seen in a Health Care
Facility (HCF) in relation to total exposures; 5) percent of cases seen
in a Hospital in relation to cases seen in a HCF; 6) percent of cases
taken to an Intensive Care Unit (ICU) in relation to cases seen in a
HCF.

**Table 4-B**. **Relative Frequency of Acute Poisoning Incidents by
Symptom Severity: [Combination of All Cases Regardless
Class]{.underline}**

+-------------------+-------+-------+-------+-------+-------+-------+
|                   | **Sev |       |       | **To  | **H   |       |
|                   | erity |       |       | tal** | ealth |       |
|                   | of    |       |       |       | c     |       |
|                   | outc  |       |       | *     | are** |       |
|                   | ome** |       |       | *expo |       |       |
|                   |       |       |       | sed** | **    |       |
|                   | **(ou |       |       |       | provi |       |
|                   | tcome |       |       |       | ded** |       |
|                   | det   |       |       |       |       |       |
|                   | ermin |       |       |       |       |       |
|                   | ed)** |       |       |       |       |       |
+===================+=======+=======+=======+=======+=======+=======+
| **Denominator     | *     |       |       | *     | *     |       |
| numbers**         | *40** |       |       | *66** | *33** |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Measures**      | **SYM | **MOD | **MAJ | **HCF | *     | **ICU |
|                   | ^1^** | ^2^** | ^3^** | ^4^** | *HOSP | ^6^** |
|                   |       |       |       |       | ^5^** |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Numerator       | *     | *     | **1** | *     | **1** | **0** |
| numbers**         | *36** | *15** |       | *33** |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **1,              | **90. | **37. | **2.  | **50. | **3.  | **0.  |
| 3-Dichloropropene | 00%** | 50%** | 50%** | 00%** | 03%** | 00%** |
| percents**        |       |       |       |       |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **All Pesticides  | **42. | **6.  | **0.  | **16. | **6.  | **2.  |
| percents**        | 69%** | 02%** | 29%** | 01%** | 05%** | 16%** |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Ratio of 1,     | *     | *     | *     | *     | **0   | **0   |
| 3                 | *2.11 | *6.23 | *8.62 | *3.12 | .50** | .00** |
| -Dichloro-propene | (S)** | (S)** | (S)** | (S)** |       |       |
| /All pesticides** |       |       |       |       | **P = | **P   |
|                   | **P   | **P = | **P = | **P = | 0     | =0    |
|                   | =0    | 0     | 0     | 0     | .47** | .39** |
|                   | .00** | .00** | .01** | .00** |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+

1\) percent with ANY symptom in relation to the total of cases followed;
2) percent with moderate symptoms in relation to the total of cases
followed; 3) percent with major or fatal outcome in relation to the
total of cases followed; 4) percent of case seen in a Health Care
Facility (HCF) in relation to total exposures; 5) percent of cases seen
in a Hospital in relation to cases seen in a HCF; 6) percent of cases
taken to an Intensive Care Unit (ICU) in relation to cases seen in a
HCF.

Table 5-B provides a summary by year, and Figure1-B shows a graphic
summary for yearly exposures cases, symptomatic cases, and cases seen in
a health care facility.

**Table 5-B [1, 3-Dichloropropene Summary of Cases by
Year]{.underline}**

  ----------- ------------- -------------- ----------- -------------- -------------- ----------- -------------- -----------
  **Year**    **Symptom**   **Moderate**   **Major**   **Cases**      **Total**      **HCF**     **Hospital**   **ICU**

  ** **       **Cases**     **Cases**      **Cases**   **Followed**   **Exposure**   **Cases**   **Cases**      **Cases**

  **1993**    **1**         **0**          **0**       **1**          **1**          **1**       **0**          **0**

  **1994**    **1**         **0**          **0**       **1**          **1**          **1**       **0**          **0**

  **1995**    **0**         **0**          **0**       **0**          **0**          **0**       **0**          **0**

  **1996**    **0**         **0**          **0**       **0**          **1**          **0**       **0**          **0**

  **1997**    **4**         **2**          **0**       **4**          **7**          **5**       **0**          **0**

  **1998**    **6**         **4**          **0**       **6**          **13**         **5**       **0**          **0**

  **1999**    **0**         **0**          **0**       **0**          **1**          **1**       **0**          **0**

  **2000**    **4**         **2**          **0**       **5**          **7**          **4**       **0**          **0**

  **2001**    **3**         **1**          **0**       **4**          **5**          **3**       **0**          **0**

  **2002**    **10**        **2**          **0**       **12**         **16**         **5**       **0**          **0**

  **2003**    **5**         **3**          **0**       **5**          **6**          **5**       **1**          **0**

  **2004**    **1**         **1**          **1**       **1**          **5**          **3**       **0**          **0**

  **2005**    **1**         **0**          **0**       **1**          **3**          **0**       **0**          **0**

  **Total**   **36**        **15**         **1**       **40**         **66**         **33**      **1**          **0**
  ----------- ------------- -------------- ----------- -------------- -------------- ----------- -------------- -----------

**Figure 1-B** Total exposure, symptomatic cases, and cases sent to HCF
by year

![](media/image3.wmf){width="6.123611111111111in"
height="4.221527777777778in"}

**[Analysis of Results]{.underline}**

For the occupational class, percentages of 1, 3-Dichloropropene are
roughly the same as the composite average; the exception is on total
exposed cases where for 1, 3-Dichloropropene the exposure is
significantly higher than the percentages for the composite. For the
non-occupational class 1, 3-Dichloropropene produces a significantly
higher number of symptomatic, moderate, major, and total exposure cases;
however the clinical side of the non-occupational table shows that
exposures to 1, 3-Dichloropropene do not produce health effects
requiring hospitalization or ICU admission. For children, there is not
much exposure, only 2 cases in 13 years of data collected. For the
combination of all classes, this is the entire population, all
measurements of symptoms and exposure are significantly higher than the
composite average while the clinical portion is well below the composite
average. This likely reflect lower usage of the chemical.

There is not a clear trend in total exposure, symptomatic cases, or
cases seen in a HCF for the 13 year-span of data collected on 1,
3-Dichloropropene; however, in the last three years the number of cases
is diminishing. The graph shows little exposure on the years 93, 94, 95,
and 96; and after a peak in 2002 a decline in exposures is noticeable.
Calculations generate a somewhat steady average of about 5 exposures per
year, 2.7 symptomatic cases per year, and 2.5 cases per year seen in a
heath care facility.

**2. B [1,3-Dichloropropene (Telone) OPP Incident Data System
(IDS)]{.underline}** **[(2001- present)]{.underline}**

A total of 12 cases were reported from 2001 to present days for 1,3-D.
For a detailed description of each case see **Attachment 1. B**

**3. B [1,3-Dichloropropene (Telone) California Pesticide Illness
Surveillance Program Data 2000-2004]{.underline}**

No activity was reported in the California Illness Surveillance Program
for Telone.

**4. B [1,3-Dichloropropene (Telone) NIOSH SENSOR]{.underline}**

Out of 5,899 reported cases from 1998 to 2003, there are only three
cases reported in the SENSOR database involving 1,3-dichloropropene. The
database shows exposure to males, one case in California, one in
Louisiana, and one in Michigan. The cases reported did not produce
symptoms.

**C) [Metam-sodium PC Code 039003]{.underline}**

**1.C Number range CHAPTER[Poison Control Center Data - 1993 through
2005 for Metam-sodium; PC Code 039003.]{.underline}**

This section discusses results from the Poison Control Center's Toxic
Exposure Surveillance System (TESS) from the years 1993 through 2005 and
reflects data collected for occupational, non-occupational, and children
class. The children class is five years of age or less (this definition
includes children about to become six years old, or up to 72 month old).
Cases involving exposures to multiple products and cases with unrelated
medical outcome are excluded. Also excluded are intentional exposures.
The tables included in this section transmit acute pesticide poisoning
incidence resulting from exposure to Metam-sodium. Pesticide poisoning
incidents reflected in these tables are likely the result of exposure to
MITC, the environmental break-down product of metam sodium.

The following tables evaluate the frequency of poisoning incidents for
Metam-sodium with the composite of [all]{.underline} pesticides for
which the PCC received a non-excluded incident report.

For a detailed explanation of the tables, see Attachment 2.

**Table 1-C**. **Relative Frequency of Acute Poisoning Incidents by
Symptom Severity: [Occupational Cases]{.underline}**

+-------------------+------+-------+-------+-------+-------+-------+
|                   | **   |       |       | **To  | **H   |       |
|                   | Seve |       |       | tal** | ealth |       |
|                   | rity |       |       |       | c     |       |
|                   | of   |       |       | *     | are** |       |
|                   | o    |       |       | *expo |       |       |
|                   | utco |       |       | sed** | **    |       |
|                   | me** |       |       |       | provi |       |
|                   |      |       |       |       | ded** |       |
|                   | **   |       |       |       |       |       |
|                   | (out |       |       |       |       |       |
|                   | come |       |       |       |       |       |
|                   | d    |       |       |       |       |       |
|                   | eter |       |       |       |       |       |
|                   | mine |       |       |       |       |       |
|                   | d)** |       |       |       |       |       |
+===================+======+=======+=======+=======+=======+=======+
| **Denominator     | **   |       |       | **    | *     |       |
| numbers**         | 90** |       |       | 167** | *76** |       |
+-------------------+------+-------+-------+-------+-------+-------+
| **Measures**      | **   | **MOD | **MAJ | **HCF | *     | **ICU |
|                   | SYM^ | ^2^** | ^3^** | ^4^** | *HOSP | ^6^** |
|                   | 1^** |       |       |       | ^5^** |       |
+-------------------+------+-------+-------+-------+-------+-------+
| **Numerator       | **   | *     | **2** | *     | **2** | **1** |
| numbers**         | 78** | *29** |       | *76** |       |       |
+-------------------+------+-------+-------+-------+-------+-------+
| **Metam-sodium    | **   | **32. | **2.  | **45. | **2.  | **1.  |
| percents**        | 86.6 | 22%** | 22%** | 51%** | 63%** | 32%** |
|                   | 7%** |       |       |       |       |       |
+-------------------+------+-------+-------+-------+-------+-------+
| **All Pesticides  | **   | **20. | **0.  | **42. | **7.  | **2.  |
| percents**        | 86.2 | 89%** | 81%** | 94%** | 00%** | 83%** |
|                   | 5%** |       |       |       |       |       |
+-------------------+------+-------+-------+-------+-------+-------+
| **Ratio of        | **1. | *     | **2   | **1   | **0   | **0   |
| Metam-sodium /All | 00** | *1.54 | .74** | .06** | .38** | .46** |
| pesticides**      |      | (S)** |       |       |       |       |
|                   | **P  |       | **P = | **P = | **P = | **P   |
|                   | =0.  | **P = | 0     | 0     | 0     | =0    |
|                   | 90** | 0     | .14** | .50** | .13** | .42** |
|                   |      | .00** |       |       |       |       |
+-------------------+------+-------+-------+-------+-------+-------+

1\) percent with ANY symptom in relation to the total of cases followed;
2) percent with moderate symptoms in relation to the total of cases
followed; 3) percent with major or fatal outcome in relation to the
total of cases followed; 4) percent of case seen in a Health Care
Facility (HCF) in relation to total exposures; 5) percent of cases seen
in a Hospital in relation to cases seen in a HCF; 6) percent of cases
taken to an Intensive Care Unit (ICU) in relation to cases seen in a
HCF.

**Table 2-C**. **Relative Frequency of Acute Poisoning Incidents by
Symptom Severity: [Non-Occupational Cases]{.underline}**

+-------------------+-------+-------+-------+-------+-------+-------+
|                   | **Sev |       |       | **To  | **H   |       |
|                   | erity |       |       | tal** | ealth |       |
|                   | of    |       |       |       | c     |       |
|                   | outc  |       |       | *     | are** |       |
|                   | ome** |       |       | *expo |       |       |
|                   |       |       |       | sed** | **    |       |
|                   | **(ou |       |       |       | provi |       |
|                   | tcome |       |       |       | ded** |       |
|                   | det   |       |       |       |       |       |
|                   | ermin |       |       |       |       |       |
|                   | ed)** |       |       |       |       |       |
+===================+=======+=======+=======+=======+=======+=======+
| **Denominator     | **    |       |       | **    | **    |       |
| numbers**         | 151** |       |       | 234** | 106** |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Measures**      | **SYM | **MOD | **MAJ | **HCF | *     | **ICU |
|                   | ^1^** | ^2^** | ^3^** | ^4^** | *HOSP | ^6^** |
|                   |       |       |       |       | ^5^** |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Numerator       | *     | *     | **0** | **    | **0** | **0** |
| numbers**         | *87** | *15** |       | 106** |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Metam-sodium    | **57. | **9.  | **0.  | **45. | **0.  | **0.  |
| percents**        | 62%** | 93%** | 00%** | 30%** | 00%** | 00%** |
+-------------------+-------+-------+-------+-------+-------+-------+
| **All Pesticides  | **64. | **10. | **0.  | **15. | **7.  | **3.  |
| percents**        | 72%** | 61%** | 45%** | 45%** | 94%** | 02%** |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Ratio of        | **0   | **0   | **0   | *     | *     | **0   |
| Metam-sodium /All | .89** | .94** | .00** | *2.93 | *0.00 | .00** |
| pesticides**      |       |       |       | (S)** | (S)** |       |
|                   | **P   | **P = | **P = |       |       | **P   |
|                   | =0    | 0     | 0     | **P = | **P = | =0    |
|                   | .07** | .78** | .41** | 0     | 0     | .07** |
|                   |       |       |       | .00** | .00** |       |
+-------------------+-------+-------+-------+-------+-------+-------+

1\) percent with ANY symptom in relation to the total of cases followed;
2) percent with moderate symptoms in relation to the total of cases
followed; 3) percent with major or fatal outcome in relation to the
total of cases followed; 4) percent of case seen in a Health Care
Facility (HCF) in relation to total exposures; 5) percent of cases seen
in a Hospital in relation to cases seen in a HCF; 6) percent of cases
taken to an Intensive Care Unit (ICU) in relation to cases seen in a
HCF.

**Table 3-C**. **Relative Frequency of Acute Poisoning Incidents by
Symptom Severity: [Children Cases]{.underline}**

+-------------------+-------+-------+-------+-------+-------+-------+
|                   | **Sev |       |       | **To  | **H   |       |
|                   | erity |       |       | tal** | ealth |       |
|                   | of    |       |       |       | c     |       |
|                   | outc  |       |       | *     | are** |       |
|                   | ome** |       |       | *expo |       |       |
|                   |       |       |       | sed** | **    |       |
|                   | **(ou |       |       |       | provi |       |
|                   | tcome |       |       |       | ded** |       |
|                   | det   |       |       |       |       |       |
|                   | ermin |       |       |       |       |       |
|                   | ed)** |       |       |       |       |       |
+===================+=======+=======+=======+=======+=======+=======+
| **Denominator     | *     |       |       | *     | **6** |       |
| numbers**         | *16** |       |       | *27** |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Measures**      | **SYM | **MOD | **MAJ | **HCF | *     | **ICU |
|                   | ^1^** | ^2^** | ^3^** | ^4^** | *HOSP | ^6^** |
|                   |       |       |       |       | ^5^** |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Numerator       | **6** | **0** | **0** | **6** | **0** | **0** |
| numbers**         |       |       |       |       |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Metam-sodium    | **37. | **0.  | **0.  | **22. | **0.  | **0.  |
| percents**        | 50%** | 00%** | 00%** | 22%** | 00%** | 00%** |
+-------------------+-------+-------+-------+-------+-------+-------+
| **All Pesticides  | **23. | **1.  | **0.  | **14. | **4.  | **1.  |
| percents**        | 16%** | 48%** | 13%** | 80%** | 48%** | 41%** |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Ratio of        | **1   | **0   | **0   | **1   | **0   | **0   |
| Metam-sodium /All | .62** | .00** | .00** | .50** | .00** | .00** |
| pesticides**      |       |       |       |       |       |       |
|                   | **P   | **P = | **P = | **P = | **P = | **P   |
|                   | =0    | 0     | 0     | 0     | 0     | =0    |
|                   | .13** | .62** | .88** | .27** | .47** | .77** |
+-------------------+-------+-------+-------+-------+-------+-------+

1\) percent with ANY symptom in relation to the total of cases followed;
2) percent with moderate symptoms in relation to the total of cases
followed; 3) percent with major or fatal outcome in relation to the
total of cases followed; 4) percent of case seen in a Health Care
Facility (HCF) in relation to total exposures; 5) percent of cases seen
in a Hospital in relation to cases seen in a HCF; 6) percent of cases
taken to an Intensive Care Unit (ICU) in relation to cases seen in a
HCF.

**Table 4-C**. **Relative Frequency of Acute Poisoning Incidents by
Symptom Severity: [Combination of All Cases Regardless
Class]{.underline}**

+-------------------+-------+-------+-------+-------+-------+-------+
|                   | **Sev |       |       | **To  | **H   |       |
|                   | erity |       |       | tal** | ealth |       |
|                   | of    |       |       |       | c     |       |
|                   | outc  |       |       | *     | are** |       |
|                   | ome** |       |       | *expo |       |       |
|                   |       |       |       | sed** | **    |       |
|                   | **(ou |       |       |       | provi |       |
|                   | tcome |       |       |       | ded** |       |
|                   | det   |       |       |       |       |       |
|                   | ermin |       |       |       |       |       |
|                   | ed)** |       |       |       |       |       |
+===================+=======+=======+=======+=======+=======+=======+
| **Denominator     | **    |       |       | **    | **    |       |
| numbers**         | 257** |       |       | 428** | 188** |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Measures**      | **SYM | **MOD | **MAJ | **HCF | *     | **ICU |
|                   | ^1^** | ^2^** | ^3^** | ^4^** | *HOSP | ^6^** |
|                   |       |       |       |       | ^5^** |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Numerator       | **    | *     | **2** | **    | **2** | **1** |
| numbers**         | 171** | *44** |       | 188** |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Metam-sodium    | **66. | **17. | **0.  | **43. | **1.  | **0.  |
| percents**        | 54%** | 12%** | 78%** | 93%** | 06%** | 53%** |
+-------------------+-------+-------+-------+-------+-------+-------+
| **All Pesticides  | **42. | **6.  | **0.  | **16. | **6.  | **2.  |
| percents**        | 69%** | 02%** | 29%** | 01%** | 05%** | 16%** |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Ratio of        | *     | *     | **2   | *     | *     | **0   |
| Metam-sodium /All | *1.56 | *2.84 | .68** | *2.74 | *0.18 | .25** |
| pesticides**      | (S)** | (S)** |       | (S)** | (S)** |       |
|                   |       |       | **P = |       |       | **P   |
|                   | **P   | **P = | 0     | **P = | **P = | =0    |
|                   | =0    | 0     | .15** | 0     | 0     | .12** |
|                   | .00** | .00** |       | .00** | .00** |       |
+-------------------+-------+-------+-------+-------+-------+-------+

1\) percent with ANY symptom in relation to the total of cases followed;
2) percent with moderate symptoms in relation to the total of cases
followed; 3) percent with major or fatal outcome in relation to the
total of cases followed; 4) percent of case seen in a Health Care
Facility (HCF) in relation to total exposures; 5) percent of cases seen
in a Hospital in relation to cases seen in a HCF; 6) percent of cases
taken to an Intensive Care Unit (ICU) in relation to cases seen in a
HCF.

Table 5-C provides a summary by year, and Figure 1-C shows a graphic
summary for yearly exposures cases, symptomatic cases, and cases seen in
a health care facility.

**Table 5-C [Metam-sodium Summary of Cases by Year]{.underline}**

  ----------- ------------- -------------- ----------- -------------- -------------- ----------- -------------- -----------
  **Year**    **Symptom**   **Moderate**   **Major**   **Cases**      **Total**      **HCF**     **Hospital**   **ICU**

  ** **       **Cases**     **Cases**      **Cases**   **Followed**   **Exposure**   **Cases**   **Cases**      **Cases**

  **1993**    **18**        **5**          **2**       **23**         **40**         **14**      **0**          **0**

  **1994**    **15**        **5**          **0**       **19**         **37**         **16**      **1**          **0**

  **1995**    **9**         **2**          **0**       **12**         **24**         **5**       **0**          **0**

  **1996**    **18**        **4**          **0**       **52**         **93**         **42**      **1**          **1**

  **1997**    **10**        **5**          **0**       **15**         **26**         **13**      **0**          **0**

  **1998**    **12**        **6**          **0**       **16**         **21**         **3**       **0**          **0**

  **1999**    **19**        **2**          **0**       **43**         **51**         **35**      **0**          **0**

  **2000**    **11**        **4**          **0**       **12**         **22**         **12**      **0**          **0**

  **2001**    **33**        **2**          **0**       **34**         **50**         **13**      **0**          **0**

  **2002**    **8**         **3**          **0**       **10**         **16**         **10**      **0**          **0**

  **2003**    **11**        **3**          **0**       **11**         **21**         **13**      **0**          **0**

  **2004**    **2**         **1**          **0**       **5**          **14**         **6**       **0**          **0**

  **2005**    **5**         **2**          **0**       **5**          **13**         **6**       **0**          **0**

  **Total**   **171**       **44**         **2**       **257**        **428**        **188**     **2**          **1**
  ----------- ------------- -------------- ----------- -------------- -------------- ----------- -------------- -----------

**Figure 1-C** Total exposure, symptomatic cases, and cases sent to HCF
by year

![](media/image4.wmf){width="6.495833333333334in"
height="4.483333333333333in"}

**[Analysis of Results]{.underline}**

For the occupational class, percentages of Metam-sodium are mixed for
different measurements; it produces average as compared to the composite
measure of symptomatic cases, significantly higher cases with moderate
symptoms and a higher proportion of cases with major symptoms. Exposure
is about average and cases where health care was provided are less than
the average. For the non-occupational class, Metam-sodium produces a
significant higher number of exposures than the composite average; but,
all other measurements are under the composite average. For the children
class there is not much exposure, only 27 suspected cases in 13 years of
data collected. The entire population table shows higher proportions in
symptoms, moderate symptoms, major symptoms, and total exposed;
nevertheless, cases that went to a Hospital or ICU are under the
composite measure.

An irregular diminishing trend in total exposure, symptomatic cases, and
cases seen in a HCF is perceptible for the 13 year-span of data
collected on Metam-sodium. Calculations generate an average of about 33
exposures per year, 13 symptomatic cases per year, and 14.5 cases per
year seen in a heath care facility. Although irregular, the yearly trend
indicates a reduction on the three measurements (HCF, symptomatic, and
total exposure) with 2005 results (6, 5, and 13) well below the yearly
average.

**2. C [Metam Sodium OPP Incident Data System (IDS)]{.underline}**
**[(2001- present)]{.underline}**

A total of 9 cases were reported from 2001 to present days on Metam
Sodium. For a detailed description of each case, see **Attachment 1. C**

**3. C [Metam-sodium California Pesticide Illness Surveillance Program
Data 2000-2004]{.underline}**

Detailed descriptions of 408 cases submitted to the California Pesticide
Illness Surveillance Program (2002-2004) were reviewed. In all 408 of
these cases, Metam sodium was used alone or was judged to be responsible
for the health effects. Only cases with a definite, probable or possible
relationship were reviewed. Table 1 presents the types of illnesses
reported by year. Table 2 gives the total number of workers that took
time off work as a result of their illness and how many were
hospitalized and for how long.

**Table 6-C**. Cases Due to Metam Sodium in California Reported by Type
of Illness and Year, 2002-2004.

  -----------------------------------------------------------------------------------------
  **Year**    **Illness                                                         
              Type**                                                            
  ----------- ------------ --------- ---------- --------------- --------------- -----------
              **Systemic   **Eye**   **Skin**   **Respiratory   **Combination   **Total**
              ^a^**                             ^b^**           ^c^**           

  **2002**    **104**      **231**   **2**      **1**           **46**          **384**

  **2003**    **15**       **1**     **1**      **2**           **-**           **19**

  **2004**    **1**        **-**     **4**      **-**           **-**           **5**

  **Total**   **120**      **232**   **7**      **3**           **46**          **408**
  -----------------------------------------------------------------------------------------

^a^ Category includes cases where skin, eye, or respiratory effects were
also reported.

^b^ Category not used until 1990. Prior respiratory cases classified as
systemic.

^c^ Category includes combined irritating effects to eye, skin, and
respiratory system.

The majority of the cases resulted in field workers who reported eye
irritation such burning and teary eyes.

**Table 7-C**. Number of Persons Disabled (taking time off work) or
Hospitalized by Indicated Number of Days after Metam Sodium Exposure in
California, 2002-2004.

  ----------------- ------------------------- ---------------------------
  **Time period**   **Number of Persons       **Number of Persons
                    Disabled**                Hospitalized**

  One day           \-                        \-

  Two days          3                         \-

  3-5 days          1                         \-

  6-10 days         \-                        1

  more than 10 days \-                        \-

  Unknown           195                       \-

  Indefinite        \-                        \-
  ----------------- ------------------------- ---------------------------

A variety of worker activities were associated with exposure to Metam
sodium as illustrated in Table 3 below.

**Table 8-C.** Illnesses by Activity Categories for Metam Sodium
Exposure in California, 2002-2004

+------------------+---------+----+-----+----------+-----------+-----+
| **Activity       | **      |    |     |          |           |     |
| Category**       | Illness |    |     |          |           |     |
|                  | Cat     |    |     |          |           |     |
|                  | egory** |    |     |          |           |     |
+==================+=========+====+=====+==========+===========+=====+
|                  | **S     | *  | **  | **Res    | **Co      | **T |
|                  | ystemic | *E | Ski | piratory | mbination | ota |
|                  | ^a^**   | ye | n** | ^b^**    | ^C^**     | l** |
|                  |         | ** |     |          |           |     |
+------------------+---------+----+-----+----------+-----------+-----+
| **Applicator**   | **5**   | *  | **  | **-**    | **-**     | **  |
|                  |         | *- | 2** |          |           | 7** |
|                  |         | ** |     |          |           |     |
+------------------+---------+----+-----+----------+-----------+-----+
| **Field Worker** | **28**  | ** | **  | **-**    | **6**     | *   |
|                  |         | 91 | -** |          |           | *12 |
|                  |         | ** |     |          |           | 5** |
+------------------+---------+----+-----+----------+-----------+-----+
| **Manufactu      | **-**   | *  | **  | **-**    | **-**     | **  |
| re/Formulation** |         | *- | 2** |          |           | 2** |
|                  |         | ** |     |          |           |     |
+------------------+---------+----+-----+----------+-----------+-----+
| **Mechanical     | **-**   | *  | **  | **-**    | **-**     | **  |
| Work on          |         | *- | 1** |          |           | 1** |
| Contaminated     |         | ** |     |          |           |     |
| Equipment**      |         |    |     |          |           |     |
+------------------+---------+----+-----+----------+-----------+-----+
| **Other          | **-**   | *  | **  | **-**    | **-**     | **  |
| Occupational     |         | *- | 1** |          |           | 1** |
| Activity**       |         | ** |     |          |           |     |
+------------------+---------+----+-----+----------+-----------+-----+
| **Other          | **-**   | *  | **  | **-**    | **-**     | **  |
| Non-Occupational |         | *1 | -** |          |           | 1** |
| Activity**       |         | ** |     |          |           |     |
+------------------+---------+----+-----+----------+-----------+-----+
| **Pack/Process** | **-**   | ** | **  | **-**    | **1**     | **7 |
|                  |         | 71 | -** |          |           | 2** |
|                  |         | ** |     |          |           |     |
+------------------+---------+----+-----+----------+-----------+-----+
| **Routine Indoor | **25**  | ** | **  | **-**    | **21**    | *   |
| Activity**       |         | 57 | -** |          |           | *10 |
|                  |         | ** |     |          |           | 3** |
+------------------+---------+----+-----+----------+-----------+-----+
| **Routine        | **62**  | ** | **  | **3**    | **18**    | **9 |
| Outdoor**        |         | 12 | -** |          |           | 5** |
|                  |         | ** |     |          |           |     |
| **Activity**     |         |    |     |          |           |     |
+------------------+---------+----+-----+----------+-----------+-----+
| **Tran           | **-**   | *  | **  | **-**    | **-**     | **  |
| sport/Storage/** |         | *- | 1** |          |           | 1** |
|                  |         | ** |     |          |           |     |
| **Disposal**     |         |    |     |          |           |     |
+------------------+---------+----+-----+----------+-----------+-----+
| **Total**        | **120** | *  | **  | **3**    | **46**    | *   |
|                  |         | *2 | 7** |          |           | *40 |
|                  |         | 32 |     |          |           | 8** |
|                  |         | ** |     |          |           |     |
+------------------+---------+----+-----+----------+-----------+-----+

**^a^** Category includes cases where skin, eye, or respiratory effects
were also reported.

**^b^** Category not used until 1990. Prior respiratory cases classified
as systemic.

**^c^** Category includes combined irritating effects to eye, skin, and
respiratory system.

According to the above activity categories, field worker was associated
with more exposures than any other category. These illnesses included
symptoms of burning and tearing eyes, irritated nasal passages,
difficulty breathing, nausea, vomiting, leg weakness, headache, and
scratchy throat.

**4. C [Metam-sodium NIOSH SENSOR]{.underline}**

Out of 5,899 reported cases from 1998 to 2003, there are sixty-two cases
reported in the SENSOR database involving Metam Sodium. Individuals
exposed were forty-two males and twenty females. Twenty-seven cases were
in California, ten in Washington State, six in Oregon, and nineteen in
Arizona. The cases reported produced a variety of symptoms that are
classified as

1.  [Respiratory symptoms]{.underline}, thirty-four cases, including
    upper respiratory pain/irritation, hyperventilation/ dyspnea,
    wheezing, etc.

2.  [Dermal symptoms]{.underline}, seventeen cases, with cases of bullae
    (blisters), burns, edema, swelling, rash, skin irritation and pain

3.  [Ocular symptoms]{.underline}, thirty-three cases, mainly with
    diagnosis of conjunctivitis

4.  [Cardio vascular symptoms,]{.underline} eleven cases counting
    tachycardia, hypotension, and hypertension.

Symptoms are not mutually exclusive; a patient may have many symptoms.

**D) [Metam-Potassium PC Code 039002]{.underline}**

**1.D Number range CHAPTER[Poison Control Center Data - 1993 through
2005 for Metam-Potassium; PC Code 039003.]{.underline}**

No activity was reported in TESS for Metam-potassium from 1993 to 2005.

**2. D [Metam-Potassium OPP Incident Data System (IDS) (2001-
present)]{.underline}**

Four cases were reported in the Incident Data System from 2001 to
present days on Metam-Potassium. For a detailed description of the case
see **Attachment 1. D**

**3. D [Metam-Potassium California Pesticide Illness Surveillance
Program Data 2000-2004]{.underline}**

Detailed descriptions of 18 cases submitted to the California Pesticide
Illness Surveillance Program (2003-2005) were reviewed. In 18 of these
cases, Metam-potassium was used alone or was judged to be responsible
for the health effects. Only cases with a definite, probable or possible
relationship were reviewed. Table 1 presents the types of illnesses
reported by year. Table 2 gives the total number of workers that took
time off work as a result of their illness and how many were
hospitalized and for how long.

**Table 1-D.** Cases Due to Metam-Potassium in California Reported by
Type of Illness and Year, 2002-2004.

  -----------------------------------------------------------------------------------------
  **Year**    **Illness                                                         
              Type**                                                            
  ----------- ------------ --------- ---------- --------------- --------------- -----------
              **Systemic   **Eye**   **Skin**   **Respiratory   **Combination   **Total**
              ^a^**                             ^b^**           ^c^**           

  **2003**    **3**        **4**     **-**      **-**           **11**          **18**

  **2004**    **-**        **-**     **-**      **-**           **-**           **-**

  **2005**    **-**        **-**     **-**      **-**           **-**           **-**

  **Total**   **3**        **4**     **-**      **-**           **11**          **18**
  -----------------------------------------------------------------------------------------

^a^ Category includes cases where skin, eye, or respiratory effects were
also reported.

^b^ Category not used until 1990. Prior respiratory cases classified as
systemic.

^c^ Category includes combined irritative effects to eye, skin, and
respiratory system.

**Table 2-D.** Number of Persons Disabled (taking time off work) or
Hospitalized for Indicated Number of Days after Metam-Potassium Exposure
in California, 2003-2005.

  ----------------- ------------------------- ---------------------------
  **Time period**   **Number of Persons       **Number of Persons
                    Disabled**                Hospitalized**

  **One day**       **-**                     **-**

  **Two days**      **-**                     **-**

  **3-5 days**      **-**                     **-**

  **6-10 days**     **-**                     **-**

  **more than 10    **-**                     **-**
  days**                                      

  **Unknown**       **18**                    **-**

  **Indefinite**    **-**                     **-**
  ----------------- ------------------------- ---------------------------

A variety of worker activities were associated with exposure to
Metam-potassium as illustrated in Table 3 below.

**Table 3-D**. Illnesses by Activity Categories for Metam Potassium;
exposure in California, 2003-2005

+-------------+----------+------+-----+----------+-----------+-------+
| **Activity  | *        |      |     |          |           |       |
| Category**  | *Illness |      |     |          |           |       |
|             | Ca       |      |     |          |           |       |
|             | tegory** |      |     |          |           |       |
+=============+==========+======+=====+==========+===========+=======+
|             | **       | **E  | **  | **Res    | **Co      | **To  |
|             | Systemic | ye** | Ski | piratory | mbination | tal** |
|             | ^a^**    |      | n** | ^b^**    | ^c^**     |       |
+-------------+----------+------+-----+----------+-----------+-------+
| **Emergency | **-**    | *    | **  | **-**    | **-**     | **1** |
| Response**  |          | *1** | -** |          |           |       |
+-------------+----------+------+-----+----------+-----------+-------+
| **Other     | **-**    | *    | **  | **-**    | **1**     | **1** |
| Non-Occ     |          | *-** | -** |          |           |       |
| upational** |          |      |     |          |           |       |
|             |          |      |     |          |           |       |
| *           |          |      |     |          |           |       |
| *Activity** |          |      |     |          |           |       |
+-------------+----------+------+-----+----------+-----------+-------+
| **Routine   | **-**    | *    | **  | **-**    | **8**     | **8** |
| Indoor**    |          | *-** | -** |          |           |       |
|             |          |      |     |          |           |       |
| *           |          |      |     |          |           |       |
| *Activity** |          |      |     |          |           |       |
+-------------+----------+------+-----+----------+-----------+-------+
| **Routine   | **3**    | *    | **  | **-**    | **2**     | **7** |
| Outdoor**   |          | *2** | -** |          |           |       |
|             |          |      |     |          |           |       |
| *           |          |      |     |          |           |       |
| *Activity** |          |      |     |          |           |       |
+-------------+----------+------+-----+----------+-----------+-------+
| **Unknown** | **-**    | *    | **  | **-**    | **-**     | **1** |
|             |          | *1** | -** |          |           |       |
| **Non-O     |          |      |     |          |           |       |
| ccupational |          |      |     |          |           |       |
| Activity**  |          |      |     |          |           |       |
+-------------+----------+------+-----+----------+-----------+-------+
| **Total**   | **3**    | *    | **  | **-**    | **11**    | *     |
|             |          | *4** | -** |          |           | *18** |
+-------------+----------+------+-----+----------+-----------+-------+

According to the above activity categories, routine indoor activity was
associated with more exposures than any other category. These illnesses
included symptoms of irritated eyes, nose, throat, and difficulty
breathing.

**4. D [Metam-Potassium NIOSH SENSOR]{.underline}**

Out of 5,899 reported cases from 1998 to 2003, there are no cases
reported in the SENSOR database involving Metam-Potassium.

**E) [Dazomet PC Codes 035602 and 035607]{.underline}**

**1.E Number range CHAPTER[Poison Control Center Data - 1993 through
2005 for Dazomet; PC Code 035602 and 035607.]{.underline}**

This section discusses results from the Poison Control Center's Toxic
Exposure Surveillance System (TESS) from the years 1993 through 2005 and
reflects data collected for occupational, non-occupational, and children
class.

For a detailed explanation of the tables, see Attachment 2.

**Table 1-E**. **Relative Frequency of Acute Poisoning Incidents by
Symptom Severity: [Occupational Cases]{.underline}**

+-------------------+------+-------+-------+-------+-------+-------+
|                   | **   |       |       | **To  | **H   |       |
|                   | Seve |       |       | tal** | ealth |       |
|                   | rity |       |       |       | c     |       |
|                   | of   |       |       | *     | are** |       |
|                   | o    |       |       | *expo |       |       |
|                   | utco |       |       | sed** | **    |       |
|                   | me** |       |       |       | provi |       |
|                   |      |       |       |       | ded** |       |
|                   | **   |       |       |       |       |       |
|                   | (out |       |       |       |       |       |
|                   | come |       |       |       |       |       |
|                   | d    |       |       |       |       |       |
|                   | eter |       |       |       |       |       |
|                   | mine |       |       |       |       |       |
|                   | d)** |       |       |       |       |       |
+===================+======+=======+=======+=======+=======+=======+
| **Denominator     | *    |       |       | *     | **4** |       |
| numbers**         | *8** |       |       | *13** |       |       |
+-------------------+------+-------+-------+-------+-------+-------+
| **Measures**      | **   | **MOD | **MAJ | **HCF | *     | **ICU |
|                   | SYM^ | ^2^** | ^3^** | ^4^** | *HOSP | ^6^** |
|                   | 1^** |       |       |       | ^5^** |       |
+-------------------+------+-------+-------+-------+-------+-------+
| **Numerator       | *    | **1** | **0** | **4** | **0** | **0** |
| numbers**         | *8** |       |       |       |       |       |
+-------------------+------+-------+-------+-------+-------+-------+
| **Dazomet         | **1  | **12. | **0.  | **30. | **0.  | **0.  |
| percents**        | 00.0 | 50%** | 00%** | 77%** | 00%** | 00%** |
|                   | 0%** |       |       |       |       |       |
+-------------------+------+-------+-------+-------+-------+-------+
| **All Pesticides  | **   | **20. | **0.  | **42. | **7.  | **2.  |
| percents**        | 86.2 | 89%** | 81%** | 94%** | 00%** | 83%** |
|                   | 5%** |       |       |       |       |       |
+-------------------+------+-------+-------+-------+-------+-------+
| **Ratio of        | **1. | **0   | **0   | **0   | **0   | **0   |
| Dazomet /All      | 16** | .60** | .00** | .72** | .00** | .00** |
| pesticides**      |      |       |       |       |       |       |
|                   | **P  | **P = | **P = | **P = | **P = | **P   |
|                   | =0.  | 0     | 0     | 0     | 0     | =0    |
|                   | 25** | .56** | .79** | .37** | .57** | .73** |
+-------------------+------+-------+-------+-------+-------+-------+

1\) percent with ANY symptom in relation to the total of cases followed;
2) percent with moderate symptoms in relation to the total of cases
followed; 3) percent with major or fatal outcome in relation to the
total of cases followed; 4) percent of case seen in a Health Care
Facility (HCF) in relation to total exposures; 5) percent of cases seen
in a Hospital in relation to cases seen in a HCF; 6) percent of cases
taken to an Intensive Care Unit (ICU) in relation to cases seen in a
HCF.

**Table 2-E**. **Relative Frequency of Acute Poisoning Incidents by
Symptom Severity: [Non-Occupational Cases]{.underline}**

+-------------------+-------+-------+-------+-------+-------+-------+
|                   | **Sev |       |       | **To  | **H   |       |
|                   | erity |       |       | tal** | ealth |       |
|                   | of    |       |       |       | c     |       |
|                   | outc  |       |       | *     | are** |       |
|                   | ome** |       |       | *expo |       |       |
|                   |       |       |       | sed** | **    |       |
|                   | **(ou |       |       |       | provi |       |
|                   | tcome |       |       |       | ded** |       |
|                   | det   |       |       |       |       |       |
|                   | ermin |       |       |       |       |       |
|                   | ed)** |       |       |       |       |       |
+===================+=======+=======+=======+=======+=======+=======+
| **Denominator     | **3** |       |       | **5** | **1** |       |
| numbers**         |       |       |       |       |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Measures**      | **SYM | **MOD | **MAJ | **HCF | *     | **ICU |
|                   | ^1^** | ^2^** | ^3^** | ^4^** | *HOSP | ^6^** |
|                   |       |       |       |       | ^5^** |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Numerator       | **2** | **1** | **0** | **1** | **0** | **0** |
| numbers**         |       |       |       |       |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Dazomet         | **66. | **33. | **0.  | **20. | **0.  | **0.  |
| percents**        | 67%** | 33%** | 00%** | 00%** | 00%** | 00%** |
+-------------------+-------+-------+-------+-------+-------+-------+
| **All Pesticides  | **64. | **10. | **0.  | **15. | **7.  | **3.  |
| percents**        | 72%** | 61%** | 45%** | 45%** | 94%** | 02%** |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Ratio of        | **1   | **3   | **0   | **1   | **0   | **0   |
| Dazomet /All      | .03** | .14** | .00** | .29** | .00** | .00** |
| pesticides**      |       |       |       |       |       |       |
|                   | **P   | **P = | **P = | **P = | **P = | **P   |
|                   | =0    | 0     | 0     | 0     | 0     | =0    |
|                   | .94** | .20** | .90** | .77** | .51** | .70** |
+-------------------+-------+-------+-------+-------+-------+-------+

1\) percent with ANY symptom in relation to the total of cases followed;
2) percent with moderate symptoms in relation to the total of cases
followed; 3) percent with major or fatal outcome in relation to the
total of cases followed; 4) percent of case seen in a Health Care
Facility (HCF) in relation to total exposures; 5) percent of cases seen
in a Hospital in relation to cases seen in a HCF; 6) percent of cases
taken to an Intensive Care Unit (ICU) in relation to cases seen in a
HCF.

**Table 3-E**. **Relative Frequency of Acute Poisoning Incidents by
Symptom Severity: [Children Cases]{.underline}**

+-------------------+-------+-------+-------+-------+-------+-------+
|                   | **Sev |       |       | **To  | **H   |       |
|                   | erity |       |       | tal** | ealth |       |
|                   | of    |       |       |       | c     |       |
|                   | outc  |       |       | *     | are** |       |
|                   | ome** |       |       | *expo |       |       |
|                   |       |       |       | sed** | **    |       |
|                   | **(ou |       |       |       | provi |       |
|                   | tcome |       |       |       | ded** |       |
|                   | det   |       |       |       |       |       |
|                   | ermin |       |       |       |       |       |
|                   | ed)** |       |       |       |       |       |
+===================+=======+=======+=======+=======+=======+=======+
| **Denominator     | **3** |       |       | **3** | **0** |       |
| numbers**         |       |       |       |       |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Measures**      | **SYM | **MOD | **MAJ | **HCF | *     | **ICU |
|                   | ^1^** | ^2^** | ^3^** | ^4^** | *HOSP | ^6^** |
|                   |       |       |       |       | ^5^** |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Numerator       | **0** | **0** | **0** | **0** | **0** | **0** |
| numbers**         |       |       |       |       |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Dazomet         | **0.  | **0.  | **0.  | **0.  | **0.  | **0.  |
| percents**        | 00%** | 00%** | 00%** | 00%** | 00%** | 00%** |
+-------------------+-------+-------+-------+-------+-------+-------+
| **All Pesticides  | **23. | **1.  | **0.  | **14. | **4.  | **1.  |
| percents**        | 16%** | 48%** | 13%** | 80%** | 48%** | 41%** |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Ratio of        | **0   | **0   | **0   | **0   | **0   | **0   |
| Dazomet /All      | .00** | .00** | .00** | .00** | .00** | .00** |
| pesticides**      |       |       |       |       |       |       |
|                   | **P   | **P = | **P = | **P = | **P = | **P = |
|                   | =0    | 0     | 0     | 0     | \--   | \--   |
|                   | .34** | .83** | .94** | .47** | \***  | \***  |
+-------------------+-------+-------+-------+-------+-------+-------+

**\* Population too small for a reliable statistical test**

1\) percent with ANY symptom in relation to the total of cases followed;
2) percent with moderate symptoms in relation to the total of cases
followed; 3) percent with major or fatal outcome in relation to the
total of cases followed; 4) percent of case seen in a Health Care
Facility (HCF) in relation to total exposures; 5) percent of cases seen
in a Hospital in relation to cases seen in a HCF; 6) percent of cases
taken to an Intensive Care Unit (ICU) in relation to cases seen in a
HCF.

**Table 4-E**. **Relative Frequency of Acute Poisoning Incidents by
Symptom Severity: [Combination of All Cases Regardless
Class]{.underline}**

+-------------------+-------+-------+-------+-------+-------+-------+
|                   | **Sev |       |       | **To  | **H   |       |
|                   | erity |       |       | tal** | ealth |       |
|                   | of    |       |       |       | c     |       |
|                   | outc  |       |       | *     | are** |       |
|                   | ome** |       |       | *expo |       |       |
|                   |       |       |       | sed** | **    |       |
|                   | **(ou |       |       |       | provi |       |
|                   | tcome |       |       |       | ded** |       |
|                   | det   |       |       |       |       |       |
|                   | ermin |       |       |       |       |       |
|                   | ed)** |       |       |       |       |       |
+===================+=======+=======+=======+=======+=======+=======+
| **Denominator     | *     |       |       | *     | **5** |       |
| numbers**         | *14** |       |       | *21** |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Measures**      | **SYM | **MOD | **MAJ | **HCF | *     | **ICU |
|                   | ^1^** | ^2^** | ^3^** | ^4^** | *HOSP | ^6^** |
|                   |       |       |       |       | ^5^** |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Numerator       | *     | **2** | **0** | **5** | **0** | **0** |
| numbers**         | *10** |       |       |       |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Dazomet         | **71. | **14. | **0.  | **23. | **0.  | **0.  |
| percents**        | 43%** | 29%** | 00%** | 81%** | 00%** | 00%** |
+-------------------+-------+-------+-------+-------+-------+-------+
| **All Pesticides  | **42. | **6.  | **0.  | **16. | **6.  | **2.  |
| percents**        | 69%** | 02%** | 29%** | 01%** | 05%** | 16%** |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Ratio of        | *     | **2   | **0   | **1   | **0   | **0   |
| Dazomet /All      | *1.67 | .37** | .00** | .49** | .00** | .00** |
| pesticides**      | (S)** |       |       |       |       |       |
|                   |       | **P = | **P = | **P = | **P = | **P   |
|                   | **P   | 0     | 0     | 0     | 0     | =0    |
|                   | =0    | .19** | .84** | .33** | .57** | .74** |
|                   | .03** |       |       |       |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+

1\) percent with ANY symptom in relation to the total of cases followed;
2) percent with moderate symptoms in relation to the total of cases
followed; 3) percent with major or fatal outcome in relation to the
total of cases followed; 4) percent of case seen in a Health Care
Facility (HCF) in relation to total exposures; 5) percent of cases seen
in a Hospital in relation to cases seen in a HCF; 6) percent of cases
taken to an Intensive Care Unit (ICU) in relation to cases seen in a
HCF.

Table 5-E provides a summary by year, and Figure 1-E shows a graphic
summary for yearly exposures cases, symptomatic cases, and cases seen in
a health care facility.

**Table 5-E [Dazomet Summary of Cases by Year]{.underline}**

  ----------- ------------- -------------- ----------- -------------- -------------- ----------- -------------- -----------
  **Year**    **Symptom**   **Moderate**   **Major**   **Cases**      **Total**      **HCF**     **Hospital**   **ICU**

  ** **       **Cases**     **Cases**      **Cases**   **Followed**   **Exposure**   **Cases**   **Cases**      **Cases**

  **1993**    **1**         **0**          **0**       **1**          **1**          **0**       **0**          **0**

  **1994**    **1**         **0**          **0**       **1**          **3**          **1**       **0**          **0**

  **1995**    **0**         **0**          **0**       **0**          **0**          **0**       **0**          **0**

  **1996**    **1**         **1**          **0**       **1**          **1**          **1**       **0**          **0**

  **1997**    **0**         **0**          **0**       **0**          **0**          **0**       **0**          **0**

  **1998**    **1**         **0**          **0**       **1**          **2**          **1**       **0**          **0**

  **1999**    **0**         **0**          **0**       **3**          **3**          **0**       **0**          **0**

  **2000**    **1**         **0**          **0**       **1**          **1**          **1**       **0**          **0**

  **2001**    **2**         **0**          **0**       **3**          **4**          **1**       **0**          **0**

  **2002**    **0**         **0**          **0**       **0**          **2**          **0**       **0**          **0**

  **2003**    **2**         **1**          **0**       **2**          **2**          **0**       **0**          **0**

  **2004**    **0**         **0**          **0**       **0**          **1**          **0**       **0**          **0**

  **2005**    **1**         **0**          **0**       **1**          **1**          **0**       **0**          **0**

  **Total**   **10**        **2**          **0**       **14**         **21**         **5**       **0**          **0**
  ----------- ------------- -------------- ----------- -------------- -------------- ----------- -------------- -----------

**\
**

**Figure 1-E** **Total exposure, symptomatic cases, and cases sent to
HCF by year**

![](media/image5.wmf){width="6.65625in" height="4.8125in"}

**[Analysis of Results]{.underline}**

Dazomet is characterized by a low rate of exposure across the different
classes. On the occupational class, percentages of Dazomet are below the
average, except for symptoms which are not significant. For the
non-occupational class, Dazomet does not produce any significant result.
For the children class there is not much exposure, only 3 suspected
cases in 13 years of data collected. The entire population table shows
higher proportions in symptoms, moderate symptoms, and total exposed
with "symptoms" as the only measurement that is significant;
nevertheless, there are no cases that went to a Hospital or ICU.

There is not an appreciable trend in total exposure, symptomatic cases,
and cases seen in a HCF for the 13 year-span of data collected on
Dazomet. Calculations generate an average of about 1.6 exposures per
year, 0.76 symptomatic cases per year, and 0.38 cases per year seen in a
health care facility.

**2. E [Dazomet OPP Incident Data System (IDS) (2003-
present)]{.underline}**

Only one case was reported from 2001 to present days on Dazomet. For a
detailed description of the case see **Attachment 1. E**

**3. E [Dazomet California Pesticide Illness Surveillance Program Data
2000-2004]{.underline}**

No activity was reported in the California Illness Surveillance Program

**4. E [Dazomet NIOSH SENSOR]{.underline}**

Out of 5,899 reported cases from 1998 to 2003, there is only one cases
reported in the SENSOR database involving Dazonet. As a result from
exposure to Dazomet, a female in California contracted dermatitis.

**F) [Chloropicrin PC Code 081501 and 081502]{.underline}**

**1.F Number range CHAPTER[Poison Control Center Data - 1993 through
2005 for Chloropicrin; PC Code 081501 and 081502.]{.underline}**

This section discusses results from the Poison Control Center's Toxic
Exposure Surveillance System (TESS) from the years 1993 through 2005 and
reflects data collected for occupational, non-occupational, and children
class. The tables included in this section transmit acute pesticide
poisoning incidence resulting from exposure to Chloropicrin.

The following tables evaluate the frequency of poisoning incidents for
Chloropicrin with the composite of [all]{.underline} pesticides for
which the PCC received a non-excluded incident report.

For a detailed explanation of the tables, see Attachment 2.

**Table 1-F**. **Relative Frequency of Acute Poisoning Incidents by
Symptom Severity: [Occupational Cases]{.underline}**

+-------------------+------+-------+-------+-------+-------+-------+
|                   | **   |       |       | **To  | **H   |       |
|                   | Seve |       |       | tal** | ealth |       |
|                   | rity |       |       |       | c     |       |
|                   | of   |       |       | *     | are** |       |
|                   | o    |       |       | *expo |       |       |
|                   | utco |       |       | sed** | **    |       |
|                   | me** |       |       |       | provi |       |
|                   |      |       |       |       | ded** |       |
|                   | **   |       |       |       |       |       |
|                   | (out |       |       |       |       |       |
|                   | come |       |       |       |       |       |
|                   | d    |       |       |       |       |       |
|                   | eter |       |       |       |       |       |
|                   | mine |       |       |       |       |       |
|                   | d)** |       |       |       |       |       |
+===================+======+=======+=======+=======+=======+=======+
| **Denominator     | *    |       |       | **4** | **4** |       |
| numbers**         | *4** |       |       |       |       |       |
+-------------------+------+-------+-------+-------+-------+-------+
| **Measures**      | **   | **MOD | **MAJ | **HCF | *     | **ICU |
|                   | SYM^ | ^2^** | ^3^** | ^4^** | *HOSP | ^6^** |
|                   | 1^** |       |       |       | ^5^** |       |
+-------------------+------+-------+-------+-------+-------+-------+
| **Numerator       | *    | **0** | **0** | **4** | **1** | **0** |
| numbers**         | *4** |       |       |       |       |       |
+-------------------+------+-------+-------+-------+-------+-------+
| **Chloropicrin    | **1  | **0.  | **0.  | *     | **25. | **0.  |
| percents**        | 00.0 | 00%** | 00%** | *100. | 00%** | 00%** |
|                   | 0%** |       |       | 00%** |       |       |
+-------------------+------+-------+-------+-------+-------+-------+
| **All Pesticides  | **   | **20. | **0.  | **42. | **7.  | **2.  |
| percents**        | 86.2 | 89%** | 81%** | 94%** | 00%** | 83%** |
|                   | 5%** |       |       |       |       |       |
+-------------------+------+-------+-------+-------+-------+-------+
| **Ratio of        | **1. | **0   | **0   | *     | **3   | **0   |
| Chloropicrin /All | 16** | .00** | .00** | *2.33 | .57** | .00** |
| pesticides**      |      |       |       | (S)** |       |       |
|                   | **P  | **P = | **P = |       | **P = | **P   |
|                   | =0.4 | 0     | 0     | **P = | 0     | =0    |
|                   | 2**  | .30** | .85** | 0     | .15** | .73** |
|                   |      |       |       | .02** |       |       |
+-------------------+------+-------+-------+-------+-------+-------+

1\) percent with ANY symptom in relation to the total of cases followed;
2) percent with moderate symptoms in relation to the total of cases
followed; 3) percent with major or fatal outcome in relation to the
total of cases followed; 4) percent of case seen in a Health Care
Facility (HCF) in relation to total exposures; 5) percent of cases seen
in a Hospital in relation to cases seen in a HCF; 6) percent of cases
taken to an Intensive Care Unit (ICU) in relation to cases seen in a
HCF.

**Table 2-F**. **Relative Frequency of Acute Poisoning Incidents by
Symptom Severity: [Non-Occupational Cases]{.underline}**

+-------------------+-------+-------+-------+-------+-------+-------+
|                   | **Sev |       |       | **To  | **H   |       |
|                   | erity |       |       | tal** | ealth |       |
|                   | of    |       |       |       | c     |       |
|                   | outc  |       |       | *     | are** |       |
|                   | ome** |       |       | *expo |       |       |
|                   |       |       |       | sed** | **    |       |
|                   | **(ou |       |       |       | provi |       |
|                   | tcome |       |       |       | ded** |       |
|                   | det   |       |       |       |       |       |
|                   | ermin |       |       |       |       |       |
|                   | ed)** |       |       |       |       |       |
+===================+=======+=======+=======+=======+=======+=======+
| **Denominator     | **8** |       |       | *     | **0** |       |
| numbers**         |       |       |       | *18** |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Measures**      | **SYM | **MOD | **MAJ | **HCF | *     | **ICU |
|                   | ^1^** | ^2^** | ^3^** | ^4^** | *HOSP | ^6^** |
|                   |       |       |       |       | ^5^** |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Numerator       | **8** | **0** | **0** | **0** | **0** | **0** |
| numbers**         |       |       |       |       |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Chloropicrin    | *     | **0.  | **0.  | **0.  | **0.  | **0.  |
| percents**        | *100. | 00%** | 00%** | 00%** | 00%** | 00%** |
|                   | 00%** |       |       |       |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **All Pesticides  | **64. | **10. | **0.  | **15. | **7.  | **3.  |
| percents**        | 72%** | 61%** | 45%** | 45%** | 94%** | 02%** |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Ratio of        | *     | **0   | **0   | **0   | **0   | **0   |
| Chloropicrin /All | *1.55 | .00** | .00** | .00** | .00** | .00** |
| pesticides**      | (S)** |       |       |       |       |       |
|                   |       | **P = | **P = | **P = | **P = | **P = |
|                   | **P   | 0     | 0     | 0     | \--   | \--   |
|                   | =0    | .33** | .85** | .07** | \***  | \***  |
|                   | .03** |       |       |       |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+

**\* Population too small for a reliable statistical test**

1\) percent with ANY symptom in relation to the total of cases followed;
2) percent with moderate symptoms in relation to the total of cases
followed; 3) percent with major or fatal outcome in relation to the
total of cases followed; 4) percent of case seen in a Health Care
Facility (HCF) in relation to total exposures; 5) percent of cases seen
in a Hospital in relation to cases seen in a HCF; 6) percent of cases
taken to an Intensive Care Unit (ICU) in relation to cases seen in a
HCF.

**Table 3-F**. **Relative Frequency of Acute Poisoning Incidents by
Symptom Severity: [Children Cases]{.underline}**

+-------------------+-------+-------+-------+-------+-------+-------+
|                   | **Sev |       |       | **To  | **H   |       |
|                   | erity |       |       | tal** | ealth |       |
|                   | of    |       |       |       | c     |       |
|                   | outc  |       |       | *     | are** |       |
|                   | ome** |       |       | *expo |       |       |
|                   |       |       |       | sed** | **    |       |
|                   | **(ou |       |       |       | provi |       |
|                   | tcome |       |       |       | ded** |       |
|                   | det   |       |       |       |       |       |
|                   | ermin |       |       |       |       |       |
|                   | ed)** |       |       |       |       |       |
+===================+=======+=======+=======+=======+=======+=======+
| **Denominator     | **0** |       |       | **0** | **0** |       |
| numbers**         |       |       |       |       |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Measures**      | **SYM | **MOD | **MAJ | **HCF | *     | **ICU |
|                   | ^1^** | ^2^** | ^3^** | ^4^** | *HOSP | ^6^** |
|                   |       |       |       |       | ^5^** |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Numerator       | **0** | **0** | **0** | **0** | **0** | **0** |
| numbers**         |       |       |       |       |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Chloropicrin    | **0.  | **0.  | **0.  | **0.  | **0.  | **0.  |
| percents**        | 00%** | 00%** | 00%** | 00%** | 00%** | 00%** |
+-------------------+-------+-------+-------+-------+-------+-------+
| **All Pesticides  | **23. | **1.  | **0.  | **14. | **4.  | **1.  |
| percents**        | 16%** | 48%** | 13%** | 80%** | 48%** | 41%** |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Ratio of        | **0   | **0   | **0   | **0   | **0   | **0   |
| Chloropicrin /All | .00** | .00** | .00** | .00** | .00** | .00** |
| pesticides**      |       |       |       |       |       |       |
|                   | **P   | **P = | **P = | **P = | **P   | **P   |
|                   | =\--  | \--   | \--   | \--   | =\--  | =\--  |
|                   | \***  | \***  | \***  | \***  | \***  | \***  |
+-------------------+-------+-------+-------+-------+-------+-------+

**\* Population too small for a reliable statistical test**

1\) percent with ANY symptom in relation to the total of cases followed;
2) percent with moderate symptoms in relation to the total of cases
followed; 3) percent with major or fatal outcome in relation to the
total of cases followed; 4) percent of case seen in a Health Care
Facility (HCF) in relation to total exposures; 5) percent of cases seen
in a Hospital in relation to cases seen in a HCF; 6) percent of cases
taken to an Intensive Care Unit (ICU) in relation to cases seen in a
HCF.

**Table 4-F**. **Relative Frequency of Acute Poisoning Incidents by
Symptom Severity: [Combination of All Cases Regardless
Class]{.underline}**

+-------------------+-------+-------+-------+-------+-------+-------+
|                   | **Sev |       |       | **To  | **H   |       |
|                   | erity |       |       | tal** | ealth |       |
|                   | of    |       |       |       | c     |       |
|                   | outc  |       |       | *     | are** |       |
|                   | ome** |       |       | *expo |       |       |
|                   |       |       |       | sed** | **    |       |
|                   | **(ou |       |       |       | provi |       |
|                   | tcome |       |       |       | ded** |       |
|                   | det   |       |       |       |       |       |
|                   | ermin |       |       |       |       |       |
|                   | ed)** |       |       |       |       |       |
+===================+=======+=======+=======+=======+=======+=======+
| **Denominator     | *     |       |       | *     | **4** |       |
| numbers**         | *12** |       |       | *22** |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Measures**      | **SYM | **MOD | **MAJ | **HCF | *     | **ICU |
|                   | ^1^** | ^2^** | ^3^** | ^4^** | *HOSP | ^6^** |
|                   |       |       |       |       | ^5^** |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Numerator       | *     | **0** | **0** | **4** | **1** | **0** |
| numbers**         | *12** |       |       |       |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Chloropicrin    | *     | **0.  | **0.  | **18. | **25. | **0.  |
| percents**        | *100. | 00%** | 00%** | 18%** | 00%** | 00%** |
|                   | 00%** |       |       |       |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **All Pesticides  | **42. | **6.  | **0.  | **16. | **6.  | **2.  |
| percents**        | 69%** | 02%** | 29%** | 01%** | 05%** | 16%** |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Ratio of        | *     | **0   | **0   | **1   | **4   | **0   |
| Chloropicrin /All | *2.34 | .00** | .00** | .14** | .13** | .00** |
| pesticides**      | (S)** |       |       |       |       |       |
|                   |       | **P = | **P = | **P = | **P = | **P   |
|                   | **P   | 0     | 0     | 0     | 0     | =0    |
|                   | =0    | .38** | .85** | .78** | .11** | .76** |
|                   | .00** |       |       |       |       |       |
+-------------------+-------+-------+-------+-------+-------+-------+

1\) percent with ANY symptom in relation to the total of cases followed;
2) percent with moderate symptoms in relation to the total of cases
followed; 3) percent with major or fatal outcome in relation to the
total of cases followed; 4) percent of case seen in a Health Care
Facility (HCF) in relation to total exposures; 5) percent of cases seen
in a Hospital in relation to cases seen in a HCF; 6) percent of cases
taken to an Intensive Care Unit (ICU) in relation to cases seen in a
HCF.

Table 5-F provides a summary by year, and Figure 1-F shows a graphic
summary for yearly exposures cases, symptomatic cases, and cases seen in
a health care facility.

**Table 5-F [Chloropicrin Summary of Cases by Year]{.underline}**

  ----------- ------------- ------------- ----------- -------------- -------------- ----------- -------------- -----------
  **Year**    **Symptom**   **Moerate**   **Major**   **Cases**      **Total**      **HCF**     **Hospital**   **ICU**

  ** **       **Cases**     **Cases**     **Cases**   **Followed**   **Exposure**   **Cases**   **Cases**      **Cases**

  **1993**    0             0             0           0              0              0           0              0

  **1994**    0             0             0           0              0              0           0              0

  **1995**    0             0             0           0              0              0           0              0

  **1996**    0             0             0           0              0              0           0              0

  **1997**    0             0             0           0              0              0           0              0

  **1998**    0             0             0           0              0              0           0              0

  **1999**    0             0             0           0              0              0           0              0

  **2000**    0             0             0           0              0              0           0              0

  **2001**    5             0             0           5              5              1           1              0

  **2002**    7             0             0           7              8              3           0              0

  **2003**    0             0             0           0              1              0           0              0

  **2004**    0             0             0           0              4              0           0              0

  **2005**    0             0             0           0              4              0           0              0

  **Total**   **12**        **0**         **0**       **12**         **22**         **4**       **1**          **0**
  ----------- ------------- ------------- ----------- -------------- -------------- ----------- -------------- -----------

**Figure 1-F** Total exposure, symptomatic cases, and cases sent to HCF
by year

![](media/image6.wmf){width="6.495833333333334in"
height="4.696527777777778in"}

**[Analysis of Results]{.underline}**

With 22 cases in 13 years, Chloropicrin presents a low rate of exposure
across the different classes. In the occupational class, only four cases
were reported and followed, and only one case was treated in the
hospital. For the non-occupational class, Chloropicrin produced symptoms
in all followed cases. For the children class no cases were reported in
13 years of data collected. The entire population table shows higher
significant proportions only in symptoms produced. It seems that once an
individual is exposed to Chloropicrin he or she will present symptoms
(100% of cases followed).

Despite that Chloropicrin has been used for more than 75 years, there
are no cases reported from 1993 to 2000. There is a cluster of cases in
2001-2002. No appreciable trend in total exposure, symptomatic cases,
and cases seen in a HCF occurred from 2001 to 2005. From 2001 to 2005,
there is an average of 4.4 exposures per year, 2.4 symptomatic cases per
year, and 0.80 cases per year seen in a health care facility.

**2. F [Chloropicrin OPP Incident Data System (IDS) (2003-
present)]{.underline}**

Only four cases were reported from 2001 to present days on Chloropicrin.
For a detailed description of the case see **Attachment 1. F**

**3. F [Chloropicrin California Pesticide Illness Surveillance Program
Data 2003-2004]{.underline}**

Detailed descriptions of 193 cases submitted to the California Pesticide
Illness Surveillance Program (2003-2004) were reviewed. In 180 of these
cases, chloropicrin was used alone or was judged to be responsible for
the health effects. Only cases with a definite, probable or possible
relationship were reviewed. Table 1 presents the types of illnesses
reported by year.

**Table 6-F.** Cases Due to Chloropicrin in California Reported by Type
of Illness and Year, 2003-2004.

  -----------------------------------------------------------------------------------------
  **Year**    **Illness                                                         
              Type**                                                            
  ----------- ------------ --------- ---------- --------------- --------------- -----------
              **Systemic   **Eye**   **Skin**   **Respiratory   **Combination   **Total**
              ^a^**                             ^b^**           ^c^**           

  **2003**    **85**       **67**    **-**      **-**           **28**          **180**

  **2004**    **-**        **-**     **-**      **-**           **-**           **-**

  **Total**   **85**       **67**    **-**      **-**           **28**          **180**
  -----------------------------------------------------------------------------------------

^a^ Category includes cases where skin, eye, or respiratory effects were
also reported.

^b^ Category not used until 1990. Prior respiratory cases classified as
systemic.

^c^ Category includes combined irritative effects to eye, skin, and
respiratory system.

A variety of worker activities were associated with exposure to
chloropicrin as illustrated in Table 7_F below.

**Table 7-F**. Illnesses by Activity Categories for Chloropicrin
Exposure in California, 2003-2004

+-------------+--------+------+-----+------------+------------+------+
| **Activity  | **I    |      |     |            |            |      |
| Category**  | llness |      |     |            |            |      |
|             | Cate   |      |     |            |            |      |
|             | gory** |      |     |            |            |      |
+=============+========+======+=====+============+============+======+
|             | **Sy   | **E  | **  | **R        | **C        | *    |
|             | stemic | ye** | Ski | espiratory | ombination | *Tot |
|             | ^a^**  |      | n** | ^b^**      | ^c^**      | al** |
+-------------+--------+------+-----+------------+------------+------+
| **A         | **-**  | *    | **  | **-**      | **1**      | *    |
| pplicator** |        | *1** | -** |            |            | *2** |
+-------------+--------+------+-----+------------+------------+------+
| **Emergency | **-**  | *    | **  | **-**      | **-**      | *    |
| Response**  |        | *8** | -** |            |            | *8** |
+-------------+--------+------+-----+------------+------------+------+
| **Field     | **-**  | *    | **  | **-**      | **-**      | *    |
| Worker**    |        | *1** | -** |            |            | *1** |
+-------------+--------+------+-----+------------+------------+------+
| **Other     | **1**  | *    | **  | **-**      | **-**      | *    |
| O           |        | *4** | -** |            |            | *5** |
| ccupational |        |      |     |            |            |      |
| Activity**  |        |      |     |            |            |      |
+-------------+--------+------+-----+------------+------------+------+
| **Routine   | **40** | **   | **  | **-**      | **13**     | **   |
| Indoor      |        | 29** | -** |            |            | 82** |
| Activity**  |        |      |     |            |            |      |
+-------------+--------+------+-----+------------+------------+------+
| **Routine   | **44** | **   | **  | **-**      | **14**     | **   |
| Outdoor**   |        | 14** | -** |            |            | 72** |
|             |        |      |     |            |            |      |
| *           |        |      |     |            |            |      |
| *Activity** |        |      |     |            |            |      |
+-------------+--------+------+-----+------------+------------+------+
| **Unknown   | **-**  | **   | **  | **-**      | **-**      | **   |
| O           |        | 10** | -** |            |            | 10** |
| ccupational |        |      |     |            |            |      |
| Activity**  |        |      |     |            |            |      |
+-------------+--------+------+-----+------------+------------+------+
| **Total**   | **85** | **   | **  | **-**      | **28**     | **1  |
|             |        | 67** | -** |            |            | 80** |
+-------------+--------+------+-----+------------+------------+------+

^a^ Category includes cases where skin, eye, or respiratory effects were
also reported.

^b^ Category not used until 1990. Prior respiratory cases classified as
systemic.

^c^ Category includes combined irritating effects to eye, skin, and
respiratory system.

According to the above activity categories, routine indoor activity was
associated with more exposures than any other category. These illnesses
included symptoms of watery and burning eyes, headache, nausea,
difficulty breathing, scratchy throat, coughing, vomiting, stomach ache,
diarrhea, chest pain, and dizziness.

**4. F [Chloropicrin NIOSH SENSOR]{.underline}**

Out of 5,899 reported cases from 1998 to 2003, there are only five cases
reported in the SENSOR database involving Chloropicrin. Four cases were
in California and one in Oregon, and all cases reported produced mild
respiratory symptoms including, upper respiratory pain/irritation and
shortness f breath.

**Summary**

The table 1-G compiles results from PCC data affecting the entire
population from all Fumigants in relation to total exposed, cases
symptomatic, and visits to a health care facility. It also provides the
percentages within each column.

**Table 1-G** Individual fumigants, by numbers / percentages of cases by
total exposure, symptomatic, and seen in a HCF

  ---------------------- ----------------- ----------------- -----------------
  **Fumigants**          **Total Exposed / **Symptomatic     **Cases seen at
                         Percentages**     Cases**           Health Care
                                                             Facility**

  **A) Methyl Bromide**  **168 / 23.8%**   **94 / 28.7%**    **79 / 25.6%**

  **B)                   **66/9.4%**       **36 / 11.0%**    **33 / 10.7%**
  1,3-Dichloropropen**                                       

  **C) Metam Sodium**    **428 / 60.7%**   **171 / 52.3%**   **188 / 60.8%**

  **D) Dazomet**         **21 / 3.0%**     **14 / 4.3%**     **5 / 1.6%**

  **F) Chloropicrin**    **22 / 3.1%**     **12 / 3.7%**     **4 / 1.3%**

  **Total Fumigants**    **705 / 100%**    **327 / 100%**    **309 / 100%**
  ---------------------- ----------------- ----------------- -----------------

According to PCC data, table 1-G indicates that Metam Sodium is the most
problematic of the fumigants of this group. Metam Sodium produces more
than 60% of all exposures, more than half of the symptomatic cases and
more than 60% of the visits to a HCF. Metam sodium is also the most
frequently used of the agricultural fumigants. Methyl Bromide is the
second most frequently cited for pesticide poisonings with about 25 % of
total exposures, symptomatic cases, and seen in a HCF.

**Graph 1-G** Cases by individual fumigants

![](media/image7.wmf){width="6.498611111111111in"
height="4.538194444444445in"}

**Recommendations**

Given that Metam Sodium presents the most exposure cases of the group,
there should be specific worker training to improve the way it is
handled. The training should include language addressing buffer zone and
time to reentry after application.

**Attachment 1. A**

**Cases from the Incident Data System**

**[Methyl Bromide Incidents -- 6(a)(2) data, (2001-
present)]{.underline}**

Incident#11790-1

A pesticide incident occurred in 2001, when methyl bromide was broadcast
injected near a home. The responsible party changed the application plan
from the approved plan and the home ended up inside the outer buffer
zones. Residents reported burning eyes, burning nose, headache, and
nausea. At least six of the individuals were treated by a physician. No
further information on the disposition of the case was reported.

Incident#12486-1

A pesticide incident occurred in 2001, when the product leaked from a
loose valve of a container. Four individuals were exposed to the
product. One of the individuals was the driver of the truck that was
transporting the container. The individual was treated at a hospital for
respiratory distress and was later released. The other three individuals
reported burning eyes, headache, dry mouth, and respiratory distress. No
further information on the disposition of the case was reported.

Incident#12672-1

A pesticide incident occurred in 2002, when a licensed methyl bromide
fumigator and another individual were found ill at one of their homes.
Two empty methyl bromide containers were outside the house on the lawn.
Both men were taken to the hospital and one of them died. The other man
was in a coma. The County Sheriff Department was investigating the
incident with the possibility of foul play being involved. No further
information on the disposition of the case was reported.

Incident#12800-1

A pesticide incident occurred in 2002, when a sixty-six year old man,
who was a chili pepper farmer and was licensed to use farm chemicals,
was killed when a pressurized cylinder exploded that he was filling with
methyl bromide. The man's son stated that this type of work was routine
for him. A farmer who was also at the site and reported chemical burns
to his skin and lungs. No further information on the disposition of the
case was reported.

Incident#13417-17

A pesticide incident occurred in 2001, when an employee, who is a
forty-two year old man, hit a valve with a wrench that was
malfunctioning in an attempt to open it. He missed the valve and hit the
tubing between the measuring tank and the valve which broke. The 1.5
pounds of the product that was in the tank blew out of the hose and a
small amount got on his skin. The man went into the shop where he washed
his face and arms. He was taken to the hospital where he was
decontaminated and admitted for observation. The man was hospitalized
for two days with a scratchy throat that lasted four days. No further
information on the disposition of the case was reported.

Incident#13364-1

A pesticide incident occurred in 2001, when a total of 30.5 acres of a
field was treated with the product for seven days. Eight residents that
live nearby reported headache, migraines, nausea, dry nose, sore throat,
chest pressure, joint pain, asthma, dizziness, sweating, coughing, and
runny noses. No further information on the disposition of the case was
reported.

Incident#13364-4

A pesticide incident occurred in 2002, when a total of 28 acres of a
field was treated with the product. Five residents that live nearby
reported headache, chest pressure, asthma, fever, coughing,
disorientation, and malaise. No further information on the disposition
of the case was reported.

Incident#13410-4

A pesticide incident occurred in 2002, when the product was applied to a
grape vineyard. The product drifted toward an adjacent uphill winery.
Four individuals from the winery were treated at the hospital. They
reported dizziness, headache, burning eyes, blurred vision, nausea,
vomiting, drowsiness, shortness of breath, mild wheezing, and heaviness
in lungs. One person was administered medication for her nausea. The
individuals were later released from the hospital. A fifth individual
reported a headache but was not treated by a physician. No further
information on the disposition of the case was reported.

Incident#13429-1

A pesticide incident occurred in 2002, when a man, who did not wear
safety glasses or goggles, was exposed to a methyl bromide and
chloropicrin product. The man depressurized one side of the glass
assembly but failed to depressurize the other side before attempting to
disconnect it. The product was still under pressure and the liquid form
of the material splashed in his face. The man immediately flushed his
face and eyes with water. He reported chemical burns on his face and
swollen eyes. The man was treated by a physician and returned to work
three days later. No further information on the disposition of the case
was reported.

Incident#13565-1

A pesticide incident occurred in 2001, when a grower applied the product
to three sites. Ten individuals reported burning eyes and nose,
headache, and nausea. Three residents that live nearby evacuated their
home for eight days. The County Agricultural Commissioner's Office
investigated the incident and determined that the grower did not follow
the approved worksite plan. Instead, the grower applied the product to a
larger area than what was allowed in the worksite plan that increased
the buffer zone distances and resulted in the buffer zones extending to
adjoining properties and residences. The grower was issued a notice of
violation for the code violations. No further information on the
disposition of the case was reported.

Incident#13590-10

A pesticide incident occurred in 2001, when a total of 30.5 acres was
treated with the product on a strawberry field. Eight out of nine
residents that live nearby reported headache, migraine, nausea, dry
nose, sore throat, chest pressure, joint pain, asthma, dizziness,
sweating, coughing and runny nose. A public meeting was held with the
concerned residents and the County Agricultural Commissioner and County
Health Commission. Nine additional individuals filed written complaints.
Five out of the additional nine individuals reported that their symptoms
started at least one week after the last block was treated. The incident
was investigated by the County Agricultural Commissioner's Office. No
violations were found during the investigation. No further information
on the disposition of the case was reported.

Incident#13913-1

A pesticide incident occurred in 2003, when pest control company
employees, who perform port container fumigation on commodities imported
into the United States, were exposed to the product. The workers do not
like wearing a self-contained breathing apparatus that is required when
methyl bromide concentrations exceed 5 ppm. Exposure to high
concentrations occurred for a few seconds each time the edge of the tarp
was raised to place the exhaust fan inside the container when the
workers began aeration. One of the workers was hospitalized for one week
and recuperated for three weeks before returning to work. The worker was
treated by a physician and was diagnosed with methyl bromide poisoning.
The worker reported slurred speech and a loss of balance. About a week
after being hospitalized the worker's methyl bromide blood level was 50
ppm and after three weeks of recovery 16 ppm. No further information on
the disposition of the case was reported.

Incident#14095-1

A pesticide incident occurred in 2003, when an imported cargo of glass
was fumigated (98% methyl bromide, 2% chloropicrin) before leaving
China. The cargo containers were opened in the United States and several
workers were overcome by the odor and transported to the hospital. The
workers reported teary eyes and respiratory problems. No further
information on the disposition of the case was reported.

Incident#14264-1

A pesticide incident occurred in 2003, when a certified methyl bromide
applicator, who works in a nursery, opened a 1.5 pound can of the
product (98% methyl bromide, 2% chloropicrin) and it splashed on his
shirt (shoulder area) and a small amount in his eyes. He immediately
removed his shirt and flushed his eyes with water for approximately 15
minutes. The applicator did not experience any symptoms. No further
information on the disposition of the case was reported.

Incident#14318-11

A pesticide incident occurred in 2002, when household goods were
fumigated in Hong Kong and then shipped to the United States. The goods
were sealed for one and ½ months. While unloading and unpacking at home
the household goods still had a very strong odor. One adult went to the
hospital and received a breathing treatment, another adult reported
chronic numbness, tingling hands, shaking, headache, memory problems,
and a sore throat. Six children were treated by a physician and reported
shaking, severe headaches, dizziness, stomachache, and nausea. The
residents feel better when they are not at home for an extended period
of time. No further information on the disposition of the case was
reported.

Incident#14330-1

A pesticide incident occurred in 2003, when a worker received a package
that was treated with the product. When she opened the crate, the woman
reported throat discomfort. No further information on the disposition of
the case was reported.

Incident#14575-1

A pesticide incident occurred in 2003, when a container of several small
cardboard cartons that contained ornaments was treated with the product
in a trailor. During the fumigation, aeration, and unloading process
three workers reported teary eyes, shortness of breath, hives, and a
rash after coming in contact with one of the fumigated cartons. The
three workers were treated by a physician. No further information on the
disposition of the case was reported.

Incident#14774-1

A pesticide incident occurred in 2003, when a man reported teary eyes
and a scratchy throat after being exposed to the product (98% methyl
bromide, 2% chloropicrin). He was using the product to eliminate pests
during a refinishing process in his workshop. The cans were stored on a
shelf and one of them rusted through and leaked its contents so he moved
them inside his home. He aired out his workshop with a fan and was going
to move the cans to a local hazardous waste repository. No further
information on the disposition of the case was reported.

Incident#15015-1

A pesticide incident occurred in 2002, when a worker, who did not wear
personal protective equipment, was exposed to the product on two
separate occasions. The worker reported central nervous system damage,
impairment of the spinal cord, permanent vertigo, diplopia, numbness and
paresthesia of lower extremities and hands, unsteady gait, loss of
periphal vision, and loss of cognition. No further information on the
disposition of the case was reported.

Incident#15161-1

A pesticide incident occurred in 2004, when several individuals removed
a tarp from cocoa beans that were treated with over 1000 pounds of the
product. One of the individuals was admitted to the intensive care unit
and placed on a respirator. The individual's father reported vomiting
and burning throat and eyes. No further information on the disposition
of the case was reported.

Incident#15369-24

A pesticide incident occurred in 2004, when a worker applied the product
(98% methyl bromide, 2% chloropicrin) to tree holes as a preplant
fumigant for almond trees. A broken application hose caused the product
to splash in his face and on his body. The worker reported severe
dizziness, nausea, vomiting, and weakness. The worker was hospitalized
for eight days. No further information on the disposition of the case
was reported.

Incident#16186-1

A pesticide incident occurred in 2005, when thirteen workers were
exposed to methyl bromide before they started their work shift. One of
the individuals, who is a fifty-three year old man, reported nausea,
vomiting, lethargy, lack of urine output, and convulsions and later
died. The details of the incident were still under investigation. No
further information on the disposition of the case was reported.

Incident#16940-7

A pesticide incident occurred in 2004, when an individual shoveled dirt
at the end of the rows to seal the plastic tarps being rolled out by the
application tractor to seal the product (57% methyl bromide and 42.6%
chloropicrin) in the field. The man reported chest pains and shortness
of breath and was hospitalized for 3 days. No further information on the
disposition of the case was reported.

Incident#17715-1

A pesticide incident occurred in 2006, when an eighteen year old man,
who has a history of acute sensitivity to chlorine, was exposed to the
product (98% methyl bromide 2% chloropicrin). The poly tubing popped off
of the shank fitting during the application process and released the
product into the air. The man reported chest pain, difficulty breathing,
heavy sweating, constricted pupils, and seemingly incoherent. No further
information on the disposition of the case was reported.

Incident#17715-2

A pesticide incident occurred in 2006, when a forty-five year old man
was exposed to the product (98% methyl bromide 2%chloropicrin) while he
replaced a leak in the tubing. He knelt in the product that he had just
finished applying on top of the ground. The man reported blisters,
swollen skin, and burns to the skin and was treated by a physician. No
further information on the disposition of the case was reported.

**Attachment 1. B**

**Cases from the Incident Data System**

**[1,3-Dichloropropen (Telone); PC Codes 029001 and 029004 -- 6(a)(2)
data, (2001- present)]{.underline}**

Incident#13846-1

A pesticide incident occurred in 2003, when an individual, who did not
wear personal protective equipment, used the product (chloropicrin and
telone) with a tractor sprayer for five hours. The individual also
changed a tank filter without personal protective equipment and the
product got on both of the hands. The product was not washed off. The
individual, who has a history of smoking and gastric esophageal reflux
disease, reported chest pain and in coordination and was treated by a
physician. The individual was administered oxygen and was placed on a
proton pump inhibitor. The individual was hospitalized for a few days
and lab results revealed cocaine use in the previous 5 days. No further
information on the disposition of the case was reported.

Incident#13856-10

A pesticide incident occurred in 2003, when the product was applied to a
field by a shallow soil injection. Twelve residents (including an eight
year old girl, a three year old boy, a six year old child, a ten year
old boy, an eleven year old child, a fourteen year old boy, a sixteen
year old child, a seventeen year old girl, a thirty-three year old
woman, and a thirty-five year old man, a thirty-nine year old woman, a
fifty-five year old man) in two adjacent homes noticed an odor and
reported burning or irritated eyes. Six residents of one of the homes
also reported sore throats. One of the children in the other house also
reported a sore throat and coughing. The fire department was contacted
and they were unable to detect an odor. No further information on the
disposition of the case was reported.

Incident#14959-9

A pesticide incident occurred in 2003, when a farm manager, who did not
wear personal protective equipment, spilled the product on his leather
boots and pants while calibrating or transferring the product from the
pig to the tank on his bedder. The manager changed his pants but
continued wearing his boots. At the end of the day, he had a burn on his
foot that was quite painful and was swollen. He also reported irritated
splotches on his skin. The man was treated by a dermatologist and did
not work for four or five days. He returned to work when his foot felt
better. About a month later, the man, who did wear personal protective
equipment (except a respirator) used the product and again (the product
did not spill on him) his feet were swollen and he was did not work for
an unspecified amount of time. No further information on the disposition
of the case was reported.

Incident#15212-2

A pesticide incident occurred in 2004, when a fifty-nine year old man,
who has a history of asthma, reported congestion and bronchospasm. The
product was injected into the soil of a golf course near his home. There
was a 108 feet buffer zone from product placement to the adjacent
property. The man used his inhaler and took Claritin D tablet and his
symptoms subsided about 8 hours later. His wife reported congestion. No
further information on the disposition of the case was reported.

Incident#15212-7

A pesticide incident occurred in 2004, when a thirty year old man
reported diarrhea for the previous 8 days. The product was applied to
the golf course where he works. No further information on the
disposition of the case was reported.

Incident#15453-6

A pesticide incident occurred in 2004, when a man reported nausea,
tremor, joint pain, and a change in blood sugar levels. The product was
applied more than 900 yards ahead (3 or 4 holes) while he mowed the
grass on a golf course. When the applicators reached hole 11, the man
was mowing the grass on hole 12. He was told to stop mowing and return
to the shop. The man was treated by a physician about 16 days later. No
further information on the disposition of the case was reported.

Incident#15669-10

A pesticide incident occurred in 2004, when the product was injected
into the soil on a farm. Later in the evening, fifteen individuals
reported teary eyes and difficulty breathing. The individuals were
treated by emergency medical technicians. No further information on the
disposition of the case was reported.

Incident#16167-3

A pesticide incident occurred in 2005, when an individual helped his
father apply the product that got on his skin. He immediately washed his
skin and reported a rash, swollen hands and feet, and difficulty
breathing. About a week later, the man was exposed to the product for a
second time and reported a rapid heart rate, difficulty breathing, and
swollen hands and feet. The man was treated by a physician. No further
information on the disposition of the case was reported.

Incident#16167-7

A pesticide incident occurred in 2005, when a California public drinking
water system was contaminated with the product. Specific symptoms were
not mentioned. No further information on the disposition of the case was
reported.

Incident#16709-1

A pesticide incident occurred in 2003, when a field was treated with the
product. The field was located about 100-150 feet away from an office
building. The fire department responded to the incident. Several workers
in the office building reported burning eyes and about 200 workers were
evacuated from the building. All office staff returned to work the
following day. No further information on the disposition of the case was
reported.

Incident#17300-1

A pesticide incident occurred in 2006, when a thirty-three year old
tobacco farmer mixed the product and spilled some of it on his shoes,
pants, arms, and hands. He washed off his arms and hands with soap and
water but did not take off his shoes until about 3 or 4 hours later. The
man reported red, irritated, and swollen feet and legs and edema. He was
treated by a physician. No further information on the disposition of the
case was reported.

Incident#17298-26

A pesticide incident occurred in 2005, when the product was applied by
chemigation. A house was located about 108 feet from the application
site but the detached garage was 72 feet from the application site. A
family, who was living in the garage, reported watery eyes, dizziness,
and sore throat. No further information on the disposition of the case
was reported.

**Attachment 1. C**

**Cases from the Incident Data System**

**[Metam-sodium -- 6(a)(2) data, (2001- present)]{.underline}**

Incident#12418-1

A pesticide incident occurred in 2001, when a man was exposed when a
hose leaked while he loaded operation at a bulk facility. He reported
breathing problems and other health effects that were not mentioned. The
man was treated by a physician at an emergency department. No further
information on the disposition of the case was reported.

Incident#13158-7

A pesticide incident occurred in 2002, when a field (per plant for
potatoes) that is located about 500 feet from houses was treated with
the product by a shank method. Several residents reported teary eyes and
difficulty breathing. Two individuals were examined by paramedics. A
seventy year old woman, who has emphysema, reported difficulty breathing
and was admitted to the hospital. The second individual, who worked at a
nearby carrot packing shed, did not seek medical care. No further
information on the disposition of the case was reported.

Incident#13175-1

A pesticide incident occurred in 2002, when the product was applied
approximately 100 feet east of a vineyard. The product was injected into
the irrigation set. When the vineyard workers arrived at the vineyard,
the applicator had just started applying a water seal. One hundred and
thirty-eight workers reported tearing and burning eyes. Some of the
workers reported a scratchy throat while they waited for their
supervisor to arrive in the field. After the supervisor arrived, he
drove to the northeast end of the vineyard to give instructions to a
girdling crew when he reported burning eyes. He quickly moved the
workers to the southern end of the field. An additional 100 workers
reported burning eyes and they were moved about one mile to the west.
The worker's symptoms then subsided. Another worker reported nausea and
was treated by a physician. No further information on the disposition of
the case was reported.

Incident#13309-6

A pesticide incident occurred in 2002, when five workers reported
burning and tearing eyes, runny nose, nausea, vomiting, and tingling
skin. Four of the workers were treated by a physician. The product was
applied with a sprinkler to a 183 acre site at a ranch. No further
information on the disposition of the case was reported.

Incident#13792-13

A pesticide incident occurred in 2003, when several fields were treated
with the product at a rate of 50 gallons per acre. A woman (one of
several families that live across the street) reported that her
children, who have a history of asthma, developed difficulty breathing.
One of the fields was treated with the shank method. Fourteen
individuals reported sore throats, headaches, stinging and watery eyes,
runny nose, flu-like symptoms, and sore neck muscles and joints. Three
individuals were treated by a physician. No further information on the
disposition of the case was reported.

Incident#14885-8

A pesticide incident occurred in 2003, when a maintenance worker
observed a pumping station at a 66 acre field during the chemigation
process when a valve broke and the worker was exposed to the product. A
pest control company performed the application to a preplant cantaloupe
field at a 15 gallon/acre rate. The pest control company was in
violation of permit conditions for leaving the application site during
the application. The worker went to the hospital and was treated for
skin irritation. He returned later and was hospitalized for a day for
difficulty breathing. No further information on the disposition of the
case was reported.

Incident#14885-41

A pesticide incident occurred in 2003, when a twenty-seven year old man
drove a pick-up truck into a 4500 gallon bulk tank that contained 3100
gallons of the product. The product spilled onto the side of the site
(approximately 300 feet long and 6 feet wide). Some of the product
splashed into his eye so he was decontaminated at the site and was
transported to the hospital. Fifty individuals were evacuated from a one
mile radius. No further information on the disposition of the case was
reported.

Incident#16107-1

A pesticide incident occurred in 2002, when a tobacco field was treated
with the product. Residents who live nearby (about 100 feet away)
reported eye irritation. A woman's husband reported burning eyes,
wheezing, and coughing. A woman reported a headache. A pesticide program
inspection was conducted by the Connecticut Department of Environmental
Protection. Fumigant warning signs were not posted within the required
time frame which is a violation. No further information on the
disposition of the case was reported.

Incident#16452-1

A pesticide incident occurred in 2005, when about one thousand workers
were harvesting grapes in the vineyard north of a carrot field that was
treated with the product. The product was applied through a sprinkler
system. About two days later, one field worker that harvested grapes
approximately ¼ mile north of the treated site and reported burning and
tearing eyes, headache, and vomiting. The worker was treated by a
physician. All of the grape harvest crews were moved to the west side of
the block and continued harvesting grapes the rest of the day. The next
day, the workers arrived to work and began harvesting grapes. Several
hours later several workers vomited. Five field workers reported
headaches, burning and tearing eyes, sore throats, numbness of the
tongue, and vomiting. The field workers were decontaminated and they
were transported to the hospital. The grape harvesting was stopped and
the crews were moved out of the area. One worker was treated at a clinic
and reported coughing, chest pain, and a sore throat. The woman returned
home and still felt ill and returned to the hospital. She continued to
report difficulty breathing and was admitted to the hospital. The woman
was diagnosed with Adult Respiratory Distress Syndrome. The worker was
in the hospital in critical condition. No further information on the
disposition of the case was reported.

**Attachment 1. D**

**Cases from the Incident Data System**

**[Metam Potassium -- 6(a)(2) data, (2003- present)]{.underline}**

Incident#5091-1

A pesticide incident occurred in 1997, when 2 workers were exposed to
the product while they walked through a field that was treated with it.
The two individuals reported nausea. No further information on the
disposition of the case was reported.

Incident#9561-1

A pesticide incident occurred in 1999, when a young girl, between 10 and
12 years old who has a history of asthma, reported lung congestion and
eye irritation. The girl was treated by a physician. The product was
applied near several homes. The closest house was about 50 feet away.
Four firemen responded to a call that they received regarding a severe
odor and eye irritation among local residents. Four firemen sprayed
water on the field and only one of them wore a respirator. They reported
respiratory irritation. No further information on the disposition of the
case was reported.

Incident14885-12

A pesticide incident occurred in 2003, when nine residents reported eye
irritation and coughing after the product was applied near their homes.
No further information on the disposition of the case was reported.

Incident#14885-48

A pesticide incident occurred in 2003, when 3 Hazardous Materials
workers reported eye irritation and coughing after the product was
applied near homes. No further information on the disposition of the
case was reported.

**Attachment 1. E**

**Cases from the Incident Data System**

**[Dazomet -- 6(a)(2) data, (2003- present)]{.underline}**

Incident#13887-2

A pesticide incident occurred in 2003, when a man, who wore shorts and
boots, applied the product. The product got on his legs and when he
washed his legs some of it got into his boots. He continued to wear the
boots for the rest of the day. The next day, the man reported
irritation. He continued to wear the boots for several more days and his
symptoms worsened and he was treated by a physician. No further
information on the disposition of the case was reported.

**Attachment 1. F**

**Cases from the Incident Data System**

**[Chloropicrin OPP Incident Data System (IDS) (2003-
present)]{.underline}**

Incident#14651-1

A pesticide incident occurred in 2003, when an applicator applied the
product to a 40 acre pre-plant onion field and the fumes from the field
drifted toward a housing area. The housing area is located about a ¼
mile from the field. One hundred and twenty-four individuals evacuated
their homes. Several individuals reported eye irritation, breathing
problems, nausea, and vomiting. Four individuals were treated by a
physician at a hospital. Other individuals were treated by paramedics
who responded to the incident. No further information on the disposition
of the case was reported.

Incident#16884-2

A pesticide incident occurred in 2005, when a grower applied it through
a drip irrigation system. Some of the product was inadvertently trapped
in lateral lines during the application. The residual product then
entered the sprinkler system and was deposited with irrigation water
onto the field surface. The product drifted toward neighborhood
residents who reported minor symptoms that were not mentioned. No
further information on the disposition of the case was reported.

Incident#16940-40

A pesticide incident occurred in 2005, when 200 office workers from a
medical equipment manufacturing facility were evacuated from their
building. Several workers reported burning eyes after a nearby field was
treated with the product. The field was located about 100-150 feet from
the office building. No further information on the disposition of the
case was reported.

Incident#16940-42

A pesticide incident occurred in 2005, when a grower began a chemigation
of the product through the drip system to tarped beds on a 12 acre and a
13 acre pre-plant strawberry block. The grower failed to close a valve
in the irrigation system line connecting the booster pump to the main
line prior to the chemigation. About 15 individuals called 911 and
reported eye irritation, shortness of breath, and nausea. Two of the
individuals were treated by a physician and paramedics treated some of
the other residents in their homes. No further information on the
disposition of the case was reported.

**Attachment 2.**

**Table Description**

The following is a general brief description of the table components
that compares pesticide **X** with the composite average of all
pesticides

**Table 1 General Explanation of Comparison of Pesticide X with the
Composite**

+-------------------+-------+-------+-------+-------+-------+-------+
|                   | **Sev |       |       | **To  | **H   |       |
|                   | erity |       |       | tal** | ealth |       |
|                   | of    |       |       |       | C     |       |
|                   | Outc  |       |       | *     | are** |       |
|                   | ome** |       |       | *Expo |       |       |
|                   |       |       |       | sed** | **    |       |
|                   | **(Ou |       |       |       | Provi |       |
|                   | tcome |       |       |       | ded** |       |
|                   | det   |       |       |       |       |       |
|                   | ermin |       |       |       |       |       |
|                   | ed)** |       |       |       |       |       |
+===================+=======+=======+=======+=======+=======+=======+
| **Denominator     | **25, |       |       | **68, | **18, |       |
| numbers**         | 549** |       |       | 005** | 084** |       |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Measures**      | **    | **    | **    | **    | **H   | **    |
|                   | SYM** | MOD** | MAJ** | HCF** | OSP** | ICU** |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Numerator       | **    | *     | **9** | **18, | **    | **    |
| numbers**         | 578** | *83** |       | 084** | 302** | 219** |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Pesticide "X"   | **2.  | **0.  | **0.  | **26. | **1.  | **1.  |
| percents**        | 26%** | 32%** | 03%** | 59%** | 67%** | 21%** |
+-------------------+-------+-------+-------+-------+-------+-------+
| **All Pesticides  | **21. | **1.  | **0.  | **15. | **4.  | **1.  |
| percents**        | 72%** | 42%** | 12%** | 68%** | 34%** | 75%** |
+-------------------+-------+-------+-------+-------+-------+-------+
| **Ratio of        | *     | *     | *     | *     | *     | **0   |
| Pesticide "X"**   | *0.10 | *0.23 | *0.25 | *1.69 | *0.38 | .69** |
|                   | (S)** | (S)** | (S)** | (S)** | (S)** |       |
| **/All            |       |       |       |       |       | **P   |
| pesticides**      | **P   | **P = | **P = | **P = | **P = | =0    |
|                   | =0    | 0     | 0     | 0     | 0     | .51** |
|                   | .00** | .00** | .01** | .00** | .00** |       |
+-------------------+-------+-------+-------+-------+-------+-------+

A)  The first row "Denominator numbers" presents all the numbers for
    pesticide "X" that will serve as denominators in the calculation of
    the percents, and they are:

    a.  In the center column, total amount of individuals exposed to
        pesticide "X" (n = 68,005) or "Total Exposed". These are cases
        collected by the Poison Control Center regardless of outcome

    b.  In the left, amount of cases followed, (n = 25,546) these cases
        have an outcome determined "Outcome determined" and these cases
        may have symptoms or may be determined as no symptomatic.

    c.  At the right of the table, cases that visited a Health Care
        Facility (n = 18084) "Health care Provided"

> B\) The row "Measures" describes the outcome of the cases: "SYM" are
> those cases that were symptomatic; "MOD" cases are those that were
> classified as moderate; "MAJ" cases were cases classified as major or
> fatal; "HCF" are cases that went to a Health Care Facility; "HOSP" are
> cases that went to a hospital; and "ICU" cases that went to an
> Intensive Care Unit.
>
> C\) The row "Numerator numbers" is actually the number of cases for
> pesticide "X" that presented the outcome describe in the "Measures"
> row.
>
> D\) The row "Pesticide "X" percents" gives the percentages on each
> measure. These percentages are calculated by dividing the numerator
> number by the denominator number (from each major section of the
> Table 1) and multiplying by 100. For example 578, 83, and 9 are
> divided by 25,549 producing the respective percents 2.26, 0.32, and
> 0.03, for SYM, MOD, and MAJ. In a similar fashion 18,084 is divided by
> 68,005 for the percentage of cases seen in a HCF of 26.59; and for the
> last section of the Table 1, 302 and 219 are divided by 18,084 to find
> the percentages of cases that went to a hospital and ICU.
>
> E\) The row "All Pesticides Percents" are percentages that were
> calculated using all cases available in the PCC database with the
> exception of cases involving exposures to multiple products, cases
> with unrelated medical outcome, and cases where the exposure was
> intentional. These exclusions make the comparison meaningful. The
> percentages serve as the baseline for the comparison with a single
> pesticide or a group.
>
> F\) The "Ratio of Pesticide "X"/All pesticides" row is obtained by
> dividing the percentages of the "X" compound by the "all pesticides"
> percentages, to obtain a dimensionless number or ratio. This ratio
> provides an idea of the relative frequency of the compound "X". For
> example, a ratio of 1 (one) indicates that the percentages are the
> same for the compound "X" and the composite of all pesticides; a
> ratio, say of 2 (two) indicates that the chemical under study produces
> twice the effect; and a ratio of 0.5 indicates that the compound has
> half of the activity of the "composite." These ratios provide a quick
> overview of the relative toxicity of the chemical.
>
> G\) Also, the "p" value that results from a Likelihood ratio test is
> entered in the ratio cell and when significant (p \< 0.05) then an
> **(S)** is entered next to the ratio to mark statistical significance.
> A cell marked with **(S)** means that the percentages that produce the
> ratios are "statistically" significant and not due to chance. The
> percentage of pesticide "X" could be higher or lower than the
> percentage produce by the composite as indicated by the ratio.
> However, when mark by an (S) the difference is significant. For
> example, a ratio = 1.6 **(S)** means the effect produced by the
> compound is higher that the effect produced by the composite and
> statistically different; a ratio = 0.7 **(S)** signifies that
> pesticide "X" has a lower effect than the composite and is
> statistically different. On the other hand, a ratio = 1.2, with no
> **(S)**, means that the percentage, although higher, is not
> statistically different from the composite.