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| **Name/Title of Meeting: Cancer Redox Biology Steering Committee      |
| Meeting**                                                             |
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| **Date of Meeting: 10/4/07 Location:** 10/2S235 conference room       |
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| **Head Organizer: David Wink**                                        |
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| **Summary Prepared By: Terry Moody**                                  |
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| Dr. Wink announced that the Redox Biology class will be offered in    |
| the Fall of 2007. Dr. Moody announced that the class has over 100     |
| registrants. The lectures will be in Bldg. 50/Rms. 1227/1233 and they |
| will be videoconferenced to NCI-Frederick (Bldg. 549, Rm. A). The     |
| lectures will be archived at                                          |
| [http://videocast.nih.gov](http://videocast.nih.gov/) and the course  |
| schedule is shown below.                                              |
|                                                                       |
| RB 2007                                                               |
|                                                                       |
| [Bldg. 50/Rms.1227/1233 at 4-6 p.m. on Tuesday afternoon]{.underline} |
|                                                                       |
| [DATE TOPIC SPEAKERS]{.underline}                                     |
|                                                                       |
| Oct. 16 Introduction, Redox Chemistry Moody, Wink                     |
|                                                                       |
| Oct. 23 Redox Biology, Physiology Wink, Gladwin                       |
|                                                                       |
| Oct. 30 Signal Transduction, CNS Moody, Pluta                         |
|                                                                       |
| Nov. 6 Epidemiology, Inflammation Ambs, Hussain                       |
|                                                                       |
| Nov. 13 Angiogenesis, Carcinogenesis Roberts, Yeh                     |
|                                                                       |
| Nov. 20 Immunology, Genomics Young, Gardner                           |
|                                                                       |
| Nov. 27 Imaging, Cancer Therapy Krishna, Mitchell                     |
|                                                                       |
| Dr. Howard Young presented on interferon gamma (IFN) 3' ARE knockout  |
| mice. The mouse survival is limited due to cardiac toxicity.          |
| Additional studies indicated that IFNγ is an immunity induced danger  |
| signal. IFNγ post-translational mechanisms of regulation include mRNA |
| stability, splicing and translation. Negative feedback controls       |
| regulate IFNγ biosynthesis and response.                              |
|                                                                       |
| Dr. Grace Yeh presented on how the aryl hydrocarbon receptor mediates |
| the expression of phase I metabolic enzymes. Aryl hydrocarbons,       |
| benzopyrene, DMBA and dioxon TCDD induced cytochromes P450 1A1, 1A2   |
| and 1B1 mRNA. The increased expression of cytochromes P450 1A1, 1A2   |
| and 1B1 caused by DMBA was reversed by the addition of sulfur-NSAIDs. |
| Mechanisms by which the aryl hydrocarbon receptors regulate the       |
| expression of phase I metabolic enzymes were discussed.               |
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