![](media/image1.wmf){width="1.125in"
height="1.0534722222222221in"}**UNITED STATES ENVIRONMENTAL PROTECTION
AGENCY**

WASHINGTON, D.C. 20460

OFFICE OF

PREVENTION, PESTICIDES AND

TOXIC SUBSTANCES

**[MEMORANDUM]{.underline}**

DATE: 07 June 2007

SUBJECT: **Chlormequat Chloride.** Screening-level Acute and Chronic
Dietary (Drinking Water Only) Exposure and Risk Assessment for the
Reregistration Eligibility Decision.

> PC Code: 018101 DP Number: D336716

REVIEWER: Donald Wilbur, Chemist

Reregistration Branch II

> Health Effects Division (7509P)

THROUGH: Sheila Piper, Chemist (CEB)

> Dietary Exposure Science Advisory Council (DESAC)
>
> Health Effects Division (7509P)
>
> And
>
> William J. Hazel, PhD, Branch Chief
>
> Reregistration Branch II
>
> Health Effects Division (7509P)

TO: Tracy Perry, Chemical Review Manager

> Special Review Branch
>
> Special Review and Reregistration Division (7508P)

**Executive Summary**

A screening-level acute and chronic dietary (drinking water only)
exposure and risk assessment was conducted for chlormequat chloride
using the Dietary Exposure Evaluation Model DEEM-FCID™, Version 2.03
which uses food consumption data from the U.S. Department of
Agriculture's Continuing Surveys of Food Intakes by Individuals (CSFII)
from 1994-1996 and 1998. The analysis was performed to support the
reregistration eligibility decision. The assessment included only the
potential for exposure through drinking water, and was conducted to
ensure that there are no serious risk concerns associated with all
registered outdoor uses including bedding plants and containerized
ornamentals in shadehouses and nurseries. This assessment is an update
to a previous screening-level chronic dietary assessment for chlormequat
chloride (C. Swartz, D332277, 11/20/2006) and incorporates a reduction
in the maximum outdoor use rate from 49.5 to 33.3 lbs a.i./A/year.

A Tier I drinking water assessment for acute and chronic dietary
exposure was provided by the Environmental Fate and Effects Division
(EFED) (M. Echeverria, D336717, 03/19/2007). The highest estimated
drinking water concentrations (EDWC) were found in surface water and
these conservative values were used for the dietary analysis.

Acute drinking water exposure estimates were generated based on the
deterministic upper bound estimates from EFED's Tier I (F)IFRA (I)ndex
(R)eservoir (S)creening (T)ool (FIRST) EDWC surface water model.
Therefore, because of the conservative nature of this model, it is
inappropriate to assess risks based upon exposures at the 99.9^th^
percentile. It is more appropriate to consider exposure at the 95^th^
percentile. The acute dietary exposure estimates from drinking water are
[below HED's level of concern (\< 100% aRfD)]{.underline} for the U.S.
population and all population subgroups at the 95^th^ percentile. The
highest exposed population subgroup was all infants (\< 1 year) at 56%
of the acute RfD of 0.9 mg/kg/day. Based on the screening-level EFED
assessment used to generate the drinking water estimates, HED concludes
that there is no concern for potential acute dietary exposure to
chlormequat chloride from drinking water.

The chronic dietary exposure estimates from drinking water are [below
HED's level of concern (\< 100% cPAD)]{.underline} for the U.S.
population and all population subgroups. The highest exposed population
subgroup was all infants (\< 1 year) at 13% of the chronic RfD of 0.05
mg/kg/day. Based on the screening-level EFED assessment used to generate
the drinking water estimates, HED concludes that there is no concern for
potential chronic dietary exposure to chlormequat chloride from drinking
water.

**I. Introduction**

Dietary risk assessment incorporates both exposure and toxicity of a
given pesticide. For acute and chronic assessments, the risk is
expressed as a percentage of a maximum acceptable dose (i.e., the dose
which HED has concluded will result in no unreasonable adverse health
effects). For non-food pesticides, this dose is referred to as the
reference dose (RfD). The RfD is equivalent to point of departure (POD),
NOAEL, LOAEL, e.g. divided by the required uncertainty or safety factors
(typically interspecies 10x and intraspecies 10x).

For acute and non-cancer chronic exposures, HED is concerned when
estimated dietary risk exceeds 100% of the aRfD or cRfD. References
which discuss acute and chronic risk assessments in more detail are
available on the EPA/pesticides web site: "Available Information on
Assessing Exposure from Pesticides, A User's Guide," 21-JUN-2000, web
link: <http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf> ;
or see SOP 99.6 (08/20/1999).

The most recent chronic dietary risk (drinking water only) assessment
for chlormequat chloride was conducted by C. Swartz (D332277,
11/20/2006).

**II. Residue Information**

Chlormequat chloride \[(2-chloroethyl)trimethylammonium chloride\] is a
non-food use plant growth regulator that belongs to the quaternary
ammonium class of chemicals. It is used on ornamental plants grown in
greenhouses, nurseries, and shadehouses. Chlormequat chloride works
through inhibition of gibberellin biosynthesis in the early stages of
the pathway. This early blockage prevents the synthesis of numerous
gibberellins needed for normal plant growth and development.

Chlormequat chloride is a non-food use chemical, it has no existing or
proposed uses (and no tolerances) that could result in exposure through
food. Therefore, the requirements of FQPA do not strictly apply to this
chemical. Because of this, the standard 10x FQPA uncertainty factor will
not be applied to this assessment.

III. **Drinking Water Data**

The estimated drinking water concentration (EDWC) estimates used in the
dietary risk assessment were provided by the Environmental Fate and
Effects Division (EFED) in the following memorandum: "*[Tier I Drinking
Water Assessment for Chlormequat Chloride in Support of Reregistration
Eligibility Decision]{.underline}*" (M. Echeverria, D336717,
03/19/2007). EDWCs were incorporated into DEEM-FCID as the food forms
"water, direct, all sources" and "water, indirect, all sources." A
summary of the EDWCs is provided in Table 1.

-   The highest EDWC was calculated in surface water using the FIRST
    model and these upper bound conservative values were used for the
    drinking water analysis.

-   Tier 1 EDWCs for surface water were generated by EFED from their
    Tier I (F)IFRA (I)ndex (R)eservoir (S)creening (T)ool (FIRST) EDWC
    surface water model

-   FIRST is a screening model designed by the Environmental Fate and
    Effects Division (EFED, 2001a) of the Office of Pesticide Programs
    to estimate pesticide concentrations found in drinking water from
    surface water sources for use in human health risk assessment. As
    such, it provides upper bound values on the concentrations that
    might be found in drinking water due to the use of a pesticide.
    FIRST is a single-event model (one runoff event), but can account
    for spray drift from multiple applications. FIRST is hardwired to
    represent the Index Reservoir, a standard water body used by the
    Office of Pesticide Programs to assess drinking water exposure
    (Office of Pesticide Programs, 2002). It is based on a real
    reservoir, Shipman City Lake in Illinois, which is known to be
    vulnerable to pesticide contamination.

-   These EDWCs were obtained from modeling using the highest use rate
    of all labeled uses with an annual application rate of 33.3 lbs
    a.i./A/year.

-   Since there were unidentified residues in the aquatic and soil
    metabolism studies that may be of risk concern, a total toxic
    residue approach that assumes all uncharacterized extractable
    residues are of equal toxicity to the parent was used to estimate
    exposure.

-   The model and its description are available at the EPA internet
    site: <http://www.epa.gov/oppefed1/models/water/>.

+--------------------------+---------------------+---------------------+
| **Table 1 Tier I EDWC    |                     |                     |
| for chlormequat chloride |                     |                     |
| for ground boom spray    |                     |                     |
| applications**           |                     |                     |
+--------------------------+---------------------+---------------------+
| **Drinking Water Source  | **Use rate (lbs     | **EDWC (ppb)**      |
| (Model)**                | a.i./A/year)**      |                     |
+--------------------------+---------------------+---------------------+
| **Surface water          | 33.3                | **2574**            |
| (FIRST)**                |                     |                     |
|                          |                     | **91**              |
| \- **Acute (peak)**      |                     |                     |
|                          |                     |                     |
| **- Chronic (annual      |                     |                     |
| mean)**                  |                     |                     |
+--------------------------+---------------------+---------------------+
| **Groundwater            | 33.3                | 24                  |
| (SCI-GROW)**             |                     |                     |
+--------------------------+---------------------+---------------------+

Numerous conservative assumptions were used by EFED to generate the
EDWCs. Based on the following, the resulting EDWCs are deterministic
upper-bound estimates.

-   Modeled values were used since no monitoring data are available

-   Assumes 100% of watershed is treated (no percent crop area data is
    available, but there is a relatively low amount of chlormequat
    chloride applied per year on a nationwide basis, including all
    indoor uses)

-   Assumes 100% of the product is absorbed into the ground and/or runs
    off (i.e.- no plants on the surface treated, all product makes
    ground contact)

-   Ground boom applications drive the risk even though limited usage is
    expected

**IV. DEEM-FCID™ Program and Consumption Information**

Chlormequat chloride acute and chronic dietary exposure assessments were
conducted using the Dietary Exposure Evaluation Model software with the
Food Commodity Intake Database DEEM-FCID™, Version 2.03 which
incorporates consumption data from USDA's Continuing Surveys of Food
Intakes by Individuals (CSFII), 1994-1996 and 1998. The 1994-96, 98 data
are based on the reported consumption of more than 20,000 individuals
over two nonconsecutive survey days. Foods "as consumed" (e.g., apple
pie) are linked to EPA-defined food commodities (e.g. apples, peeled
fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or
N/S, baked) using publicly available recipe translation files developed
jointly by USDA/ARS and EPA. For chronic exposure assessment,
consumption data are averaged for the entire U.S. population and within
population subgroups, but for acute exposure assessment are retained as
individual consumption events. Based on analysis of the 1994-96, 98
CSFII consumption data, which took into account dietary patterns and
survey respondents, HED concluded that it is most appropriate to report
risk for the following population subgroups: the general U.S.
population, all infants (\<1 year old), children 1-2, children 3-5,
children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50+
years old.

For acute exposure assessments, individual one-day food consumption data
are used on an individual-by-individual basis. The reported consumption
amounts of each food item can be multiplied by a residue point estimate
and summed to obtain a total daily pesticide exposure for a
deterministic exposure assessment, or "matched" in multiple random
pairings with residue values and then summed in a probabilistic
assessment. The resulting distribution of exposures is expressed as a
percentage of the acute hazard value (aRfD or aPAD) on both a user
(i.e., only those who reported eating relevant commodities/food forms)
and a per-capita (i.e., those who reported eating the relevant
commodities as well as those who did not) basis. In accordance with HED
policy, per capita exposure and risk are reported for all tiers of
analysis. However, for tiers 1 and 2, any significant differences in
user vs. per capita exposure and risk are specifically identified and
noted in the risk assessment.

For chronic dietary exposure assessments, an estimate of the residue
level in each food or food-form (e.g., orange or orange juice) on the
food commodity residue list is multiplied by the average daily
consumption estimate for that food/food form to produce a residue intake
estimate. The resulting residue intake estimate for each food/food form
is summed with the residue intake estimates for all other food/food
forms on the commodity residue list to arrive at the total average
estimated exposure. Exposure is expressed in mg/kg body weight/day and
as a percent of the cRfD or cPAD. This procedure is performed for each
population subgroup.

# V. Toxicological Information

The toxicology database for chlormequat chloride is adequate sufficient
for hazard assessment to support the proposed non-food, non-residential
use. A summary of the toxicological endpoints for dietary risk
assessment is shown in Table 2.

+---------+-------+-------------+-------------+---------------------+
| **Table |       |             |             |                     |
| 2.      |       |             |             |                     |
| Summary |       |             |             |                     |
| of      |       |             |             |                     |
| Toxico  |       |             |             |                     |
| logical |       |             |             |                     |
| Doses   |       |             |             |                     |
| and     |       |             |             |                     |
| En      |       |             |             |                     |
| dpoints |       |             |             |                     |
| for     |       |             |             |                     |
| Chlo    |       |             |             |                     |
| rmequat |       |             |             |                     |
| C       |       |             |             |                     |
| hloride |       |             |             |                     |
| for Use |       |             |             |                     |
| in      |       |             |             |                     |
| Dietary |       |             |             |                     |
| E       |       |             |             |                     |
| xposure |       |             |             |                     |
| Risk    |       |             |             |                     |
| Assess  |       |             |             |                     |
| ments** |       |             |             |                     |
+---------+-------+-------------+-------------+---------------------+
| **Expo  | **    | **          | **RfD**     | **Study and         |
| sure/** | Point | Uncertainty |             | Toxicological       |
|         | of    | Factors**   |             | Effects**           |
| **Sce   | D     |             |             |                     |
| nario** | epart |             |             |                     |
|         | ure** |             |             |                     |
+---------+-------+-------------+-------------+---------------------+
| **Acute | N     | UF~A~ = 10X | aRfD=0.9    | Prenatal            |
| Di      | OAEL= |             |             | Developmental-Rat   |
| etary** |       | UF~H~ = 10X | mg/kg/day   | (MRID 42246604)     |
| (all    | 90    |             |             |                     |
| popul   | mg/k  |             |             | Single oral LOAEL   |
| ations) | g/day |             |             | 180 mg/kg/day,      |
|         |       |             |             | based on overt      |
|         |       |             |             | toxicity signs      |
|         |       |             |             | (tremors, ataxia)   |
|         |       |             |             | within an hour      |
|         |       |             |             | after a single oral |
|         |       |             |             | dose in dams(GD6).  |
+---------+-------+-------------+-------------+---------------------+
| **Acute | N/A   | N/A         | N/A         | The risk assessment |
| Di      |       |             |             | is not appropriate. |
| etary** |       |             |             | Also, an acute      |
|         |       |             |             | endpoint was not    |
| (       |       |             |             | selected based on   |
| Females |       |             |             | the absence of an   |
| 13-49   |       |             |             | appropriate         |
| years   |       |             |             | endpoint            |
| of age) |       |             |             | attributable to a   |
|         |       |             |             | single dose.        |
+---------+-------+-------------+-------------+---------------------+
| **      | NOAEL | UF~A~ = 10X | cRfD = 0.05 | Chronic             |
| Chronic | =     |             | mg/kg/day   | Toxicity-Dog (MRID  |
| Di      |       | UF~H~ = 10X |             | 46715201)           |
| etary** | 5     |             |             |                     |
|         | mg/k  |             |             | LOAEL (mg/kg/day):  |
| (all    | g/day |             |             | 10 mg/kg/day, based |
| popul   |       |             |             | on salivation (both |
| ations) |       |             |             | sexes), vomiting    |
|         |       |             |             | (females), diarrhea |
|         |       |             |             | (males), and        |
|         |       |             |             | decreased body      |
|         |       |             |             | weight gain         |
|         |       |             |             | (males).            |
+---------+-------+-------------+-------------+---------------------+
| Cancer  |       | Clas        |             |                     |
| (oral,  |       | sification: |             |                     |
| dermal, |       | "Not likely |             |                     |
| inha    |       | to be       |             |                     |
| lation) |       | C           |             |                     |
|         |       | arcinogenic |             |                     |
|         |       | to Humans"  |             |                     |
|         |       | based on    |             |                     |
|         |       | the no      |             |                     |
|         |       | c           |             |                     |
|         |       | arcinogenic |             |                     |
|         |       | potential   |             |                     |
|         |       | was noted   |             |                     |
|         |       | in the      |             |                     |
|         |       | available   |             |                     |
|         |       | studies.    |             |                     |
+---------+-------+-------------+-------------+---------------------+

Point of Departure (POD) = A data point or an estimated point that is
derived from observed dose-response data and used to mark the beginning
of extrapolation to determine risk associated with lower environmentally
relevant human exposures.

NOAEL = no observed adverse effect level.

LOAEL = lowest observed adverse effect level.

UF = uncertainty factor.

UF~A~ = extrapolation from animal to human (intraspecies).

UF~H~ = potential variation in sensitivity among members of the human
population (interspecies).

RfD = reference dose.

N/A = not applicable

[FQPA and Uncertainty Factors]{.underline}

As the pesticidal uses of chlormequat chloride do not involve use on
food, no residues in food are expected and tolerances are not required.
Therefore, chlormequat chloride uses **are not subject to the Food
Quality Protection Act (1996).**

HED notes there is no evidence chlormequat causes increased
susceptibility in infants and children in the submitted data. The
standard UF of 100X (10X interspecies extrapolation, 10X intraspecies
variability) has been applied to the hazard component of risk.

**VI. Results/Discussion**

As stated above, for dietary assessments HED is concerned when dietary
risk exceeds 100% of the hazard value (aRfD, aPAD, cRfD, or cPAD). The
DEEM-FCID™ analyses estimate the dietary exposure of the U.S. population
and various population subgroups. The results reported in Table 3 are
for the general U.S. Population, all infants (\<1 year old), children
1-2, children 3-5, children 6-12, youth 13-19, females 13-49, adults
20-49, and adults 50+ years.

*[Acute Drinking Water Exposure Results]{.underline}*

Acute drinking water exposure estimates were generated based on the
deterministic upper bound estimates from EFED's Tier I (F)IFRA (I)ndex
(R)eservoir (S)creening (T)ool (FIRST) EDWC surface water model.
Therefore, because of the conservative nature of this model, it is
inappropriate to assess risks based upon exposures at the 99.9^th^
percentile. It is more appropriate to consider exposure at the 95^th^
percentile. The acute dietary exposure estimates from drinking water are
[below HED's level of concern (\< 100% aRfD)]{.underline} for the U.S.
population and all population subgroups at the 95^th^ percentile. A
summary of the results from the acute dietary exposure analysis is shown
in Table 3. The highest exposed population subgroup was all infants (\<
1 year) at 56% of the acute RfD of 0.9 mg/kg/day. Based on the
screening-level EFED assessment used to generate the drinking water
estimates, HED concludes that there is no concern for potential acute
dietary exposure to chlormequat chloride from drinking water.

*[Chronic Drinking Water Exposure Results]{.underline}*

The chronic dietary exposure estimates from drinking water are [below
HED's level of concern (\< 100% cPAD)]{.underline} for the U.S.
population and all population subgroups. The highest exposed population
subgroup was all infants (\< 1 year) at 13% of the chronic RfD of 0.05
mg/kg/day. Based on the screening-level EFED assessment used to generate
the drinking water estimates, HED concludes that there is no concern for
potential chronic dietary exposure to chlormequat chloride from drinking
water.

+-----------------+--------+--------+-------+--------+--------+--------+
| **Table 3.      |        |        |       |        |        |        |
| Summary of      |        |        |       |        |        |        |
| Acute and       |        |        |       |        |        |        |
| Chronic Dietary |        |        |       |        |        |        |
| (Drinking Water |        |        |       |        |        |        |
| Only) Exposure  |        |        |       |        |        |        |
| and Risk for    |        |        |       |        |        |        |
| Chlormequat     |        |        |       |        |        |        |
| Chloride**      |        |        |       |        |        |        |
+=================+========+========+=======+========+========+========+
| Population      | Acute  |        |       | C      |        |        |
| Subgroup        | Dr     |        |       | hronic |        |        |
|                 | inking |        |       | Dr     |        |        |
|                 | Water  |        |       | inking |        |        |
|                 |        |        |       | Water  |        |        |
|                 | 95^th^ |        |       |        |        |        |
|                 | Perc   |        |       |        |        |        |
|                 | entile |        |       |        |        |        |
+-----------------+--------+--------+-------+--------+--------+--------+
|                 | aRfD   | D      | \%    | cRFD   | D      | \%     |
|                 | (mg/k  | ietary | aRfD  | (mg/k  | ietary | cRfD   |
|                 | g/day) | Ex     |       | g/day) | Ex     |        |
|                 |        | posure |       |        | posure |        |
|                 |        | (mg/k  |       |        |        |        |
|                 |        | g/day) |       |        | (mg/k  |        |
|                 |        |        |       |        | g/day) |        |
+-----------------+--------+--------+-------+--------+--------+--------+
| General U.S.    | 0.9    | 0.     | 15    | 0.05   | 0.     | 3.8    |
| Population      |        | 134463 |       |        | 001918 |        |
+-----------------+--------+--------+-------+--------+--------+--------+
| **All Infants   |        | **0.50 | *     |        | **0.00 | **13** |
| (\< 1 year      |        | 6963** | *56** |        | 6288** |        |
| old)**          |        |        |       |        |        |        |
+-----------------+--------+--------+-------+--------+--------+--------+
| Children 1-2    |        | 0.     | 23    |        | 0.     | 5.7    |
| years old       |        | 210983 |       |        | 002848 |        |
+-----------------+--------+--------+-------+--------+--------+--------+
| Children 3-5    |        | 0.     | 21    |        | 0.     | 5.3    |
| years old       |        | 192735 |       |        | 002666 |        |
+-----------------+--------+--------+-------+--------+--------+--------+
| Children 6-12   |        | 0.     | 15    |        | 0.     | 3.7    |
| years old       |        | 134174 |       |        | 001839 |        |
+-----------------+--------+--------+-------+--------+--------+--------+
| Youth 13-19     |        | 0.     | 12    |        | 0.     | 2.8    |
| years old       |        | 109085 |       |        | 001386 |        |
+-----------------+--------+--------+-------+--------+--------+--------+
| Adults 20-49    |        | 0.     | 14    |        | 0.     | 3.6    |
| years old       |        | 124579 |       |        | 001791 |        |
+-----------------+--------+--------+-------+--------+--------+--------+
| Adults 50+      |        | 0.     | 13    |        | 0.     | 3.8    |
| years old       |        | 112502 |       |        | 001884 |        |
+-----------------+--------+--------+-------+--------+--------+--------+
| Females 13-49   |        | 0.     | 14    |        | 0.     | 3.6    |
| years old       |        | 125285 |       |        | 001783 |        |
+-----------------+--------+--------+-------+--------+--------+--------+

**VII. Conclusion**

The acute and chronic dietary exposure analyses of conservative surface
water concentrations of chlormequat chloride indicate that all
population subgroups have risk estimates [below HED's level of concern
(\< 100% of the hazard value)]{.underline}.

**VIII. List of Attachments**

-   Attachment 1 Acute Inputs

-   Attachment 2 Acute Results

-   Attachment 3 Chronic Inputs

-   Attachment 4 Chronic Results

**Attachment 1: Acute Inputs**

U.S. Environmental Protection Agency Ver. 2.02

DEEM-FCID Acute analysis for CHLORMEQUAT CHLORIDE

Residue file name: C:\\Documents and Settings\\dwilbur\\My
Documents\\DEEM\\Chlormequat Chloride\\CC acute.R98

Analysis Date 06-04-2007 Residue file dated: 05-17-2007/08:40:38/8

Reference dose (aRfD) = 0.9 mg/kg bw/day

Comment: Chlormequat chloride acute NOAEL=90 mg/kg/day

\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--

EPA Crop Def Res Adj.Factors Comment

Code Grp Food Name (ppm) #1 #2

\-\-\-\-\-\-\-- \-\-\--
\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--
\-\-\-\-\-\-\-\-\-- \-\-\-\-\-- \-\-\-\-\-- \-\-\-\-\-\--

86010000 O Water, direct, all sources 2.574000 1.000 1.000

86020000 O Water, indirect, all sources 2.574000 1.000 1.000

**Attachment 2: Acute Results**

U.S. Environmental Protection Agency Ver. 2.02

DEEM-FCID ACUTE Analysis for CHLORMEQUAT CHLORIDE (1994-98 data)

Residue file: CC acute.R98 Adjustment factor #2 NOT used.

Analysis Date: 06-04-2007/11:57:32 Residue file dated:
05-17-2007/08:40:38/8

Daily totals for food and foodform consumption used.

Run Comment: \"Chlormequat chloride acute NOAEL=90 mg/kg/day\"

===============================================================================

Summary calculations (per capita):

95th Percentile 99th Percentile 99.9th Percentile

Exposure % aRfD Exposure % aRfD Exposure % aRfD

\-\-\-\-\-\-\-\-\-- \-\-\-\-\-\-\-- \-\-\-\-\-\-\-\-\-- \-\-\-\-\-\-\--
\-\-\-\-\-\-\-\-\-- \-\-\-\-\-\-\--

U.S. Population:

0.134463 14.94 0.252560 28.06 0.505316 56.15

All infants:

0.506963 56.33 0.726768 80.75 1.301874 144.65

Children 1-2 yrs:

0.210983 23.44 0.352343 39.15 0.512433 56.94

Children 3-5 yrs:

0.192735 21.42 0.302097 33.57 0.493062 54.78

Children 6-12 yrs:

0.134174 14.91 0.223095 24.79 0.304673 33.85

Youth 13-19 yrs:

0.109085 12.12 0.183531 20.39 0.330092 36.68

Adults 20-49 yrs:

0.124579 13.84 0.208625 23.18 0.377378 41.93

Adults 50+ yrs:

0.112502 12.50 0.160887 17.88 0.260907 28.99

Females 13-49 yrs:

0.125285 13.92 0.201640 22.40 0.357586 39.73

**Attachment 3: Chronic Inputs**

U.S. Environmental Protection Agency Ver. 2.00

DEEM-FCID Chronic analysis for CHLORMEQUAT CHLORIDE 1994-98 data

Residue file: C:\\Documents and Settings\\dwilbur\\My
Documents\\DEEM\\Chlormequat Chloride\\Chlormequat Chloride.R98

Adjust. #2 used

Analysis Date 04-17-2007 Residue file dated: 04-17-2007/10:05:37/8

Reference dose (RfD) = 0.05 mg/kg bw/day

\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--

Food Crop Residue Adj.Factors Comment

EPA Code Grp Food Name (ppm)

#1 #2

\-\-\-\-\-\-\-- \-\-\--
\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--
\-\-\-\-\-\-\-\-\-- \-\-\-\-\-- \-\-\-\-\--

86010000 O Water, direct, all sources 0.091000 1.000 1.000

86020000 O Water, indirect, all sources 0.091000 1.000 1.000

**Attachment 4: Chronic Results**

U.S. Environmental Protection Agency Ver. 2.00

DEEM-FCID Chronic analysis for CHLORMEQUAT CHLORIDE (1994-98 data)

Residue file name: C:\\Documents and Settings\\dwilbur\\My
Documents\\DEEM\\Chlormequat Chloride\\Chlormequat Chloride.R98

Adjustment factor #2 used.

Analysis Date 04-17-2007/10:06:36 Residue file dated:
04-17-2007/10:05:37/8

Reference dose (RfD, Chronic) = .05 mg/kg bw/day

=============================================================================

Total exposure by population subgroup

\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--

Total Exposure

\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--

Population mg/kg Percent of

Subgroup body wt/day Rfd

\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--
\-\-\-\-\-\-\-\-\-\-\-\-- \-\-\-\-\-\-\-\-\-\-\-\-\-\--

U.S. Population (total) 0.001918 3.8%

U.S. Population (spring season) 0.001901 3.8%

U.S. Population (summer season) 0.002060 4.1%

U.S. Population (autumn season) 0.001854 3.7%

U.S. Population (winter season) 0.001854 3.7%

Northeast region 0.001750 3.5%

Midwest region 0.001939 3.9%

Southern region 0.001823 3.6%

Western region 0.002198 4.4%

Hispanics 0.002177 4.4%

Non-hispanic whites 0.001871 3.7%

Non-hispanic blacks 0.001821 3.6%

Non-hisp/non-white/non-black 0.002351 4.7%

All infants (\< 1 year) 0.006288 12.6%

Nursing infants 0.002332 4.7%

Non-nursing infants 0.007790 15.6%

Children 1-6 yrs 0.002680 5.4%

Children 7-12 yrs 0.001742 3.5%

Females 13-19 (not preg or nursing) 0.001350 2.7%

Females 20+ (not preg or nursing) 0.001915 3.8%

Females 13-50 yrs 0.001856 3.7%

Females 13+ (preg/not nursing) 0.001865 3.7%

Females 13+ (nursing) 0.002657 5.3%

Males 13-19 yrs 0.001411 2.8%

Males 20+ yrs 0.001719 3.4%

Seniors 55+ 0.001883 3.8%

Children 1-2 yrs 0.002848 5.7%

Children 3-5 yrs 0.002666 5.3%

Children 6-12 yrs 0.001839 3.7%

Youth 13-19 yrs 0.001386 2.8%

Adults 20-49 yrs 0.001791 3.6%

Adults 50+ yrs 0.001884 3.8%

Females 13-49 yrs 0.001783 3.6%

\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--