![](media/image1.jpeg){width="2.8in" height="1.0777777777777777in"}

**BNL-7 RUN**

**FINAL REPORT**

# Marcelo E. Vazquez

####### Medical Department

**NASA-BNL Liaison Scientist**

**February 2001**

**TABLE OF CONTENTS**

Executive Summary 3

BNL-7 Proposals 4

Participants 5

Participants Statistics 7

Participants Institutions 8

Run Dates/Beam Time Description 9

Statistics 10

Beam Characteristics 11

Run Statistics and Incidents 12

Experimenters and Run Statistics 13

Participants, Experimental Samples and Endpoints 14

List of Personnel 16

**EXECUTIVE SUMMARY**

During the Winter of 2001, a series of radiobiological and physics
experiments were performed using the BNL's Alternating Gradient
Synchrotron to accelerate iron ion beams (Experiment 957, BNL-7). These
experiments were part of the seventh consecutive run sponsored by NASA's
Space Radiation Health Program (SRHP) heavy ion radiobiology research
program at BNL.

A total of 24 proposals (from 25 proposals submitted) were approved to
participate in the BNL-7 run, 7 of which were renewals, fourth were
continuing projects and fourteen, which were new proposals. From the
total number 23 were full proposals and 2 were piggyback experiments.
Six proposals declined to participate. Nineteen institutions from the
United States (10 states), and 5 from foreign countries (Italy, Japan
and England) were represented, totaling 81 users. More than 1600
biological samples were irradiated at the AGS A-3 beam line, employing
89.5 hours of beam time. In addition, 37 hours were used for physics
experiments, and a total of 21 hours were necessary for beam
characterization, tuning, dosimetry, and calibration. A total of 35.5
hours of beam time were lost (19%) due to accelerator or power supply
related problems.

During BNL-7, AGS provided iron beams with an energy of: 1 GeV/nucleon
(1.046 GeV/nucleon\*, LET: 148 keV/µm), for biology and physics
experiments. The dose/rates used were as low as 10 cGy/min and as high
as 15 Gy/min. The spill rate employed was 30 spills/min with a duration
of 500-600 msec/spill. The spill fluence was (particles/spill) 1 x 10^8^
(max) and 1.5 x 10^5^ (min). The intensities (particles/cm^2^/sec on
target) used during the run were 1 x 10^8^ (max) and 400 (min). A 7.5-cm
diameter beam spot was employed as a nominal spot for the majority of
the exposures. For larger samples (animals), an elliptical spot was used
(up to 9 cm).

Tandem-Booster set-up started on Jan. 4 with the transport and
circulation of Fe beams at the AGS complex. Beam was tuned into cave on
Jan. 6 and 1.08 GeV/u ^56^Fe beam was available for tuning on Jan. 8.
The next several shifts were spent on tuning into the target area, beam
diagnostics and establishing several different combinations of beam
intensities and spot shapes and sizes for biology running. Biology
studies started early on Jan. 9 (biology, NYU Medical Center, F. Burns)
and proceeded with several interruptions through early Jan. 11, after
which the machine operations was more stable. After all biology
experiments were completed, LBNL (C. Zeitlin) ran 37 hours of
fragmentation physics studies with 1.2 GeV/u ^56^Fe. BNL-7 finished at
2300 PM on Jan. 15

Radiobiological experiments employed cells, tissues, and intact
specimens, which required a complex coordination and planning of their
respective logistic support. Biological studies used human, mouse, rat
and hamster cell lines, human-hamster hybrid cell lines, tumor cell
lines and intact specimens (rodents and fish). Physics experiments
involved the exposure of solid state detectors and spacecraft materials.
The full program was completed in 8 days.

> \*Actual beam energy on target

**BNL-7 Projects Reviewed by the BNL's Scientific Advisory Committee in
Radiobiology**

  ------------- --------------------- --------- ------------- ---------------- -------------- -------------------
  **Project**   **P.I.**                                      **Status**       **SACR         **BNL-7**
                                                                               Review**       

  ** **         ** **                                                                         **Participation**

  **B-1**       **Miller**                                    **Renewal**      **Approved**   **Yes**

  **B-7**       **Rabin**                                     **Renewal**      **Approved**   **Yes**

  **B-10**      **P. Chang**                                  **New**          **Approved**   **No**

  **B-12**      **Hei**                                       **Continuing**   **Approved**   **Yes**

  **B-18**      **Cooper**                                    **New**          **Approved**   **Yes**

  **B-19/20**   **Kronenberg**                                **Renewal**      **Approved**   **Yes**

  **B-25**      **Evans**                                     **Renewal**      **Approved**   **Yes**

  **B-29**      **Natarajan\***                 **Renewal**                    **Approved**   **Yes**

  **B-30**      **Kale**                                      **Continuing**   **Approved**   **No**

  **B-32**      **Dicello**                                   **Renewal**      **Approved**   **Yes**

  **B-39**      **Burns**                                     **Renewal**      **Approved**   **Yes**

  **B-42**      **Barcellos-Hoff**                            **Continuing**   **Approved**   **Yes**

  **B-43**      **Nelson**                                    **Continuing**   **Approved**   **Yes**

  **B-44**      **Durante/Belli**                             **New**          **Approved**   **Yes**

  **B-45**      **Setlow**                                    **New**          **Approved**   **Yes**

  **B-46**      **Barbanel**                                  **New**          **Not          **No**
                                                                               Approved**     

  **B-47**      **Nelson**                                    **New**          **Approved**   **Yes**

  **B-48**      **Green**                                     **New**          **Approved**   **Yes**

  **B-49**      **Cucinota-Kawata**                           **New**          **Approved**   **No**

  **B-50**      **Cucinota-Wu**                               **New**          **Approved**   **No**

  **B-51**      **Murnane**                                   **New**          **Approved**   **Yes**

  **B-52**      **Gerwitz**           **New**                                  **Approved**   **Yes**

  **B-53**      **Lupton**                                    **New**          **Approved**   **Yes**

  **B-54**      **Kennedy**                                   **New**          **Approved**   **No**

  **B-55**      **Vazquez**                                   **New**          **Approved**   **Yes**
  ------------- --------------------- --------- ------------- ---------------- -------------- -------------------

**\*Piggyback experiment with B-47 project (Nelson)**

**BNL-7 PARTICIPANTS**

+----+--------------+-----------------------------+-------------------+
| ** | **Pa         | **Affiliation**             | **Title**         |
| Ex | rticipants** |                             |                   |
| p. |              |                             |                   |
| ** |              |                             |                   |
+----+--------------+-----------------------------+-------------------+
| B  | C. Zeitlin.  | Lawrence Berkeley National  | Ph.D., Principal  |
| -1 |              | Laboratory, CA              | Investigator      |
|    | J. Miller    |                             |                   |
|    |              | \"                          | Ph.D.,            |
|    | L. Heilbronn |                             | Co-Principal      |
|    |              | \"                          | Investigator      |
|    | R.P. Sigh    |                             | Ph.D., Co-Worker  |
|    |              | \"                          |                   |
|    | W. Holley    |                             | Ph.D., Co-Worker  |
|    |              | \"                          |                   |
|    | M. Nyman     |                             | Ph.D., Co-Worker  |
|    |              | "                           |                   |
|    | W.           |                             | Ph.D., Co-Worker  |
|    | Schimmerling | NASA, HDQ, DC               |                   |
|    |              |                             | Ph.D., Co-Worker  |
|    | F. Cuccinota | NASA, JSC, TX               |                   |
|    |              |                             | Ph.D., Co-Worker  |
|    | M. Cosolino  | University of Rome, Thor    |                   |
|    |              | Vergara, Italy              | Ph.D., Co-Worker  |
|    | V. Bidoli    |                             |                   |
|    |              | "                           | Ph.D., Co-Worker  |
|    | W. Sanita    |                             |                   |
|    |              | "                           | Ph.D., Co-Worker  |
|    | L. Narici    |                             |                   |
|    |              | "                           | Ph.D., Co-Worker  |
|    | R. Wilkins   |                             |                   |
|    |              | Prairie View A&M University | Ph.D., Co-Worker  |
|    | H. Huff      |                             |                   |
|    |              | "                           | Ph.D., Co-Worker  |
|    | R. Maurer    |                             |                   |
|    |              | APL, John Hopkins           | Ph.D., Co-Worker  |
|    | D. Roth      | University, MD              |                   |
|    |              |                             | Ph.D., Co-Worker  |
|    | D. Stephens  | "                           |                   |
|    |              |                             | Ph.D. Student     |
|    | J. Kinnison  | Colorado State University,  |                   |
|    |              | CO                          | Ph.D. Student     |
|    |              |                             |                   |
|    |              | "                           |                   |
+----+--------------+-----------------------------+-------------------+
| B  | B. Rabin     | University of Maryland,     | Ph.D., Principal  |
| -7 |              | Baltimore County, MD        | Investigator      |
|    | J. Joseph    |                             |                   |
|    |              | Human Nutrition Research    | Ph.D.,            |
|    | B.           | Center on Aging, MA         | Co-Principal      |
|    | Sukit-Hale   |                             | Investigator      |
|    |              | "                           |                   |
|    | J. McEwen    |                             | Co-Worker         |
|    |              | "                           |                   |
|    | S.           |                             | Co-Worker         |
|    | Szprengiel   |                             |                   |
|    |              |                             | Co-Worker         |
+----+--------------+-----------------------------+-------------------+
| B- | T. Hei       | Columbia University, NY     | Ph.D. Principal   |
| 12 |              |                             | Investigator      |
|    | L. Smilenov  | "                           |                   |
|    |              |                             | Ph.D., Co-Worker  |
|    | C. Piao      | "                           |                   |
|    |              |                             | Ph.D., Co-Worker  |
|    | M. Suzuki    | "                           |                   |
|    |              |                             | Ph.D., Co-Worker  |
+----+--------------+-----------------------------+-------------------+
| B- | P. Cooper\*  | Lawrence Berkeley National  | Ph.D., Principal  |
| 18 |              | Laboratory, CA              | Investigator      |
|    | B. Rydberg   |                             |                   |
|    |              | "                           | Ph.D.,            |
|    | B. Cooper    |                             | Co-Principal      |
|    |              | "                           | Investigator      |
|    |              |                             |                   |
|    |              |                             | Student           |
+----+--------------+-----------------------------+-------------------+
| B- | A.           | Lawrence Berkeley National  | Ph.D., Principal  |
| 19 | Kronenberg   | Laboratory, CA              | Investigator      |
|    |              |                             |                   |
| B- | C. Wiese     | \"                          | Post-Doctoral     |
| 20 |              |                             | Student           |
|    | S. Gauny     | \"                          |                   |
|    |              |                             | Senior Research   |
|    | J. Hain      | "                           | Associate         |
|    |              |                             |                   |
|    |              |                             | Ph.D., Co-Worker  |
+----+--------------+-----------------------------+-------------------+
| B- | H. Evans     | Case Western Reserve        | Ph.D., Principal  |
| 25 |              | University, OH              | Investigator      |
|    | T. Evans     |                             |                   |
|    |              | \"                          | Co-Worker         |
|    | J. Schwartz  |                             |                   |
|    |              | "                           | Ph.D., Co-Worker  |
+----+--------------+-----------------------------+-------------------+
| B- | M. Natarajan | The University of Texas     | Ph.D., Principal  |
| 29 |              | Health Sci., TX             | Investigator      |
+----+--------------+-----------------------------+-------------------+
| B- | J. Dicello   | NSBRI, John Hopkins         | Ph.D., Principal  |
| 32 |              | University, MD              | Investigator      |
|    | D. Huso      |                             |                   |
|    |              | "                           | DVM, Ph.D.,       |
|    | Y. Zhang     |                             | Co-Worker         |
|    |              | "                           |                   |
|    | J. Man       |                             | MD\. Co-Worker    |
|    |              | "                           |                   |
|    | D. Simonson  |                             | DVM Co-Worker     |
|    |              | "                           |                   |
|    | R. Arbona    |                             | MS. Co-Worker     |
|    |              | "                           |                   |
|    | A. Chesnut   |                             | MD\. Co-Worker    |
|    |              | "                           |                   |
|    |              |                             | MS. Co-Worker     |
+----+--------------+-----------------------------+-------------------+
| B- | F. Burns     | New York University Medical | Ph.D., Principal  |
| 39 |              | Center, NY                  | Investigator      |
|    | J. Xu        |                             |                   |
|    |              | "                           | Co-Worker         |
+----+--------------+-----------------------------+-------------------+
|    |              |                             |                   |
+----+--------------+-----------------------------+-------------------+
|    |              |                             |                   |
+----+--------------+-----------------------------+-------------------+
| B- | M.           | Lawrence Berkeley National  | Ph.D., Principal  |
| 42 | Barc         | Laboratory, CA              | Investigator      |
|    | ellos-Hoff\* |                             |                   |
|    |              | "                           | Co-Worker         |
|    | R. Henshall  |                             |                   |
|    |              | Colorado State University,  | Co-Worker         |
|    | S. Pearson   | CO                          |                   |
+----+--------------+-----------------------------+-------------------+
| B- | G. Nelson    | Loma Linda University, CA   | Ph.D., Principal  |
| 43 |              |                             | Investigator      |
|    | T. Jones     | "                           |                   |
|    |              |                             | BS., Co-Worker    |
|    | M. Pecaut    | "                           |                   |
|    |              |                             | BS, Co-Worker     |
|    | A. Smith     | "                           |                   |
|    |              |                             | BS, Co-Worker     |
|    | G. Peterson  | "                           |                   |
|    |              |                             | BS, Co-Worker     |
+----+--------------+-----------------------------+-------------------+
| B- | M. Durante\* | University "Federico II",   | Ph.D., Principal  |
| 44 |              | Napoli, Italy               | Investigator      |
|    | M. Belli     |                             |                   |
|    |              | National Institute of       | Ph.D., Co-Worker  |
|    | F. Antonelli | Health, Rome, Italy         |                   |
|    |              |                             | Ph.D., Co-Worker  |
|    | G. Simone    | "                           |                   |
|    |              |                             | Ph.D., Co-Worker  |
|    |              | "                           |                   |
+----+--------------+-----------------------------+-------------------+
| B- | R. Setlow    | Brookhaven National         | Ph.D., Principal  |
| 45 |              | Laboratory, NY              | Investigator      |
|    | J. Jardine   |                             |                   |
|    |              | "                           | BS, Co-Worker     |
|    | A. Shima     |                             |                   |
|    |              | University of Tokyo, Japan  | Ph.D., Co-Worker  |
+----+--------------+-----------------------------+-------------------+
| B- | G. Nelson    | Loma Linda University, CA   | Ph.D., Principal  |
| 47 |              |                             | Investigator      |
|    | > A. Smith   | "                           |                   |
|    |              |                             | Ph.D., Co-Worker  |
|    | G. Peterson  | "                           |                   |
|    |              |                             | BS, Co-Worker     |
|    | R. Dutta-Roy | "                           |                   |
|    |              |                             | BS, Co-Worker     |
|    | D. Murray    | "                           |                   |
|    |              |                             | BS, Co-Worker     |
|    | M. Kadhim    | MRC, England                |                   |
|    |              |                             | Ph.D., Co-Worker  |
+----+--------------+-----------------------------+-------------------+
| B- | L. Green\*   | Loma Linda University, CA   | Ph.D., Principal  |
| 48 |              |                             | Investigator      |
|    | G. Nelson    | "                           |                   |
|    |              |                             | Ph.D., Co-Worker  |
|    | D. Murray    | "                           |                   |
|    |              |                             | BS, Co-Worker     |
|    | T. Jones     | "                           |                   |
|    |              |                             | BS, Co-Worker     |
+----+--------------+-----------------------------+-------------------+
| B- | J. Murnane\* | University of California,   | Ph.D., Principal  |
| 51 |              | San Francisco, CA           | Investigator      |
|    | B. Fouladi   |                             |                   |
|    |              | "                           | Ph.D., Co-Worker  |
+----+--------------+-----------------------------+-------------------+
| B- | J. Gerwitz\* | NSBRI, University of        | Ph.D., Principal  |
| 52 |              | Pennsylvania                | Investigator      |
|    | B.           |                             |                   |
|    | Sutherland   | Brookhaven National         | Ph.D.,            |
|    |              | Laboratory, NY              | Co-Investigator   |
|    | P. Bennett   |                             |                   |
|    |              | "                           | MS., Biology      |
|    | J.           |                             | Associate.        |
|    | Sutherland   | "                           |                   |
|    |              |                             | Ph.D., Co-Worker  |
|    | P. Guida     | "                           |                   |
|    |              |                             | Ph.D., Co-Worker  |
|    | J. Trunk     | "                           |                   |
|    |              |                             | Co-Worker         |
|    | D.           | "                           |                   |
|    | Monteleone   |                             | Co-Worker         |
+----+--------------+-----------------------------+-------------------+
| B- | J. Lupton\*  | NSBRI, Texas A&M            | Ph.D., Principal  |
| 53 |              | University, TX              | Investigator      |
|    | L. Braby     |                             |                   |
|    |              | "                           | Ph.D.,            |
|    | N. Turner    |                             | Co-Investigator   |
|    |              | "                           |                   |
|    | S. Taddeo    |                             | Ph.D.,            |
|    |              | "                           | Co-Investigator   |
|    | N. Popovic   |                             |                   |
|    |              | "                           | Co-Worker         |
|    | M. Young     |                             |                   |
|    | Hong         | "                           | Co-Worker         |
|    |              |                             |                   |
|    | C. Henderson | "                           | Co-Worker         |
|    |              |                             |                   |
|    |              |                             | Co-Worker         |
+----+--------------+-----------------------------+-------------------+
| B- | M. Vazquez   | NSBRI, Brookhaven National  | MD, Ph.D.,        |
| 55 |              | Laboratory, NY              | Principal Invest. |
|    | Gaofeng Fan  |                             |                   |
|    |              | "                           | MD, Ph.D.,        |
|    | Luis Estevez |                             | Co-Worker         |
|    |              | "                           |                   |
|    | Stefanie     |                             | BS, Co-Worker     |
|    | Otto         | "                           |                   |
|    |              |                             | BS, Co-Worker.    |
|    | Kay Conkling | "                           |                   |
|    |              |                             | BS, Co-Worker     |
|    | Divine Adika | "                           |                   |
|    |              |                             | BS, Co-Worker     |
+----+--------------+-----------------------------+-------------------+

**\*Not present during the actual run**

**BNL-7** **PARTICIPANTS STATISTICS**

**BNL-7 Participant Institutions**

**[NASA related centers/institutes]{.underline} (4)**

-   **NASA, Headquarters, DC**

-   **NASA, Johnson Space Center, TX**

-   **NSCORT, LBNL-CSU**

-   **National Space Biomedical Research Institute, TX**

**[National Laboratories/Institutes]{.underline} (3)**

-   **Brookhaven National Laboratory, NY**

-   **Lawrence Berkeley National Laboratory, CA**

-   **Human Nutrition Research Center on Aging, MA**

**[Universities]{.underline} (12)**

-   **Prairie View A&M University**

-   **Colorado State University, CO**

-   **APL, John Hopkins University, MD**

-   **University of Maryland, Baltimore County, MD**

-   **Columbia University, NY**

-   **Case Western Reserve University, OH**

-   **The University of Texas Health Sciences., TX**

-   **New York University Medical Center, NY**

-   **Loma Linda University, CA**

-   **Texas A&M University, TX**

-   **University of California, San Francisco, CA**

-   **University of Pennsylvania, PA**

**[Foreign Institutions]{.underline} (5)**

-   **University of Rome, Thor Vergara, Italy**

-   **University "Federico II", Napoli, Italy**

-   **National Institute of Health, Rome, Italy**

-   **University of Tokyo, Japan**

-   **MRC, England**

# 

# BNL-7 RUN DATES

  ----------------------------------- --------------- ---------- ------------ ----------
  **Run dates**                       **Scheduled**              **Actual**   

                                      **Date**        **Time**   **Date**     **Time**

  **Run start**                       **01/08**       **0800**   **01/08**    **0800**

  **Run end**                         **01/14**       **1400**   **01/15**    **2300**

                                                                              

  **Tuned into cave**                 **01/9**        **0100**   **01/9**     **0100**

                                                                              

  **Beam delivered for Biology**                                              

  **Fe 1 GeV/n**                      **01/09**       **0100**   **01/09**    **0100**

  **End run**                         **01/13**       **0600**   **01/14**    **1000**

                                                                              
  ----------------------------------- --------------- ---------- ------------ ----------

**Beam Time Description (hours)**

+-------------------------+------------------+---------+--------------+
| **Total Clock Time**    | **(from 01/08    |         | **183**      |
|                         | 0800 to 01/15    |         |              |
|                         | 2300)**          |         |              |
+-------------------------+------------------+---------+--------------+
|                         |                  |         |              |
+-------------------------+------------------+---------+--------------+
| **Total Beam-on Time**  |                  |         | **147.5      |
|                         |                  |         | (81%)**      |
+-------------------------+------------------+---------+--------------+
|                         |                  |         |              |
+-------------------------+------------------+---------+--------------+
| **Total Beam-off time** |                  |         | **35.5       |
|                         |                  |         | (19%)**      |
+-------------------------+------------------+---------+--------------+
|                         |                  | **T     | **183.0      |
|                         |                  | otal:** | (100%)**     |
+-------------------------+------------------+---------+--------------+
| **Beam Time for         | **89.5 (61%)**   |         |              |
| Biology**               |                  |         |              |
+-------------------------+------------------+---------+--------------+
|                         |                  |         |              |
+-------------------------+------------------+---------+--------------+
| **Beam Time for         | **37 (25%)**     |         |              |
| Physics**               |                  |         |              |
+-------------------------+------------------+---------+--------------+
|                         |                  |         |              |
+-------------------------+------------------+---------+--------------+
| > **Beam time for       | **21 (14%)**     |         |              |
| > dosimetry,            |                  |         |              |
| > calibration, tuning,  |                  |         |              |
| > etc.**                |                  |         |              |
+-------------------------+------------------+---------+--------------+
|                         |                  |         |              |
+-------------------------+------------------+---------+--------------+
| **Totals**              | **165**          |         |              |
+-------------------------+------------------+---------+--------------+

**Descriptive statistics**

![](media/image2.wmf)

-   **AGS fe 1 GeV/n Beam Availability**

![](media/image3.wmf)

-   **Distribution of Beam Time Usage:**

![](media/image4.wmf)

# 

# Distribution of Beam Time for Biology:

# 

# 

#  

# IRON BEAM CHARACTERISTICS

+--------------------------------+-------------------------------------+
|                                | **^56^Fe^26^**                      |
+--------------------------------+-------------------------------------+
|                                | **1000 MeV/n**                      |
+--------------------------------+-------------------------------------+
| **Fluence                      | **1 x 10^8^**                       |
| (particles/cm^2^/sec)**        |                                     |
|                                | **400**                             |
| **Maximum on target**          |                                     |
|                                |                                     |
| **Minimum on target**          |                                     |
+--------------------------------+-------------------------------------+
| **Spill rate (spills/min)**    | **18**                              |
+--------------------------------+-------------------------------------+
| **Spill length (msec)**        | **500-600**                         |
+--------------------------------+-------------------------------------+
| **Particles/spill**            | **1 x 10^8^**                       |
|                                |                                     |
| > **Maximum**                  | **1.5 x 10^5^**                     |
|                                |                                     |
| #### Minimum                   |                                     |
+--------------------------------+-------------------------------------+
| **Beam spot diameter (cm)**    | **5\* - 7.5 - 9**                   |
+--------------------------------+-------------------------------------+
| **Beam cut off length.**       | **\<1%**                            |
+--------------------------------+-------------------------------------+
| **Actual Energy (MeV/n)**      | **1078**                            |
|                                |                                     |
| ##### Extracted                | **1046**                            |
|                                |                                     |
| > **On Target**                |                                     |
+--------------------------------+-------------------------------------+
| **Actual LET on Target         | **148**                             |
| (keV/µm)**                     |                                     |
+--------------------------------+-------------------------------------+
| **Dose/rate recorded           | **1000**                            |
| (cGy/min)**                    |                                     |
|                                | **30**                              |
| **Maximum**                    |                                     |
|                                |                                     |
| **Minimum**                    |                                     |
+--------------------------------+-------------------------------------+
| **Minimum dose exposure        | **1**                               |
| (cGy)**                        |                                     |
+--------------------------------+-------------------------------------+
| **No of hours for beam         | **21**                              |
| characterization, tuning**     |                                     |
|                                |                                     |
| **and dosimetry**              |                                     |
+--------------------------------+-------------------------------------+

######## BNL-7 Run Statistics and Incidents

+----------+-----+--------+--------+----------------------------------+
| **Date** | **S | **Beam | **Beam | **Remarks**                      |
|          | hif | On**   | Off**  |                                  |
|          | t** |        |        |                                  |
+----------+-----+--------+--------+----------------------------------+
| **01     | **  | **8**  | **0**  | **1 GeV Iron run start, beam     |
| /08/01** | 2** |        |        | tuned into the cave**            |
+----------+-----+--------+--------+----------------------------------+
|          | **  | **8**  | **0**  | **Beam tuning for biology.**     |
|          | 3** |        |        |                                  |
+----------+-----+--------+--------+----------------------------------+
| **01     | **  | **4**  | **4**  | **Biology run start. Power       |
| /09/01** | 1** |        |        | supply trip off.**               |
+----------+-----+--------+--------+----------------------------------+
|          | **  | **1**  | **7**  | **Power supply off. Magnet       |
|          | 2** |        |        | problems.**                      |
+----------+-----+--------+--------+----------------------------------+
|          | **  | *      | *      | **RF problems**                  |
|          | 3** | *7.5** | *0.5** |                                  |
+----------+-----+--------+--------+----------------------------------+
| **01     | **  | **3**  | **5**  | ## Cont                          |
| /10/01** | 1** |        |        | roller for the Booster RF failed |
+----------+-----+--------+--------+----------------------------------+
|          | **  | **8**  | **0**  | **No incidents**                 |
|          | 2** |        |        |                                  |
+----------+-----+--------+--------+----------------------------------+
|          | **  | *      | *      | **RF problems**                  |
|          | 3** | *5.5** | *2.5** |                                  |
+----------+-----+--------+--------+----------------------------------+
| **01     | **  | *      | *      | **RF problems**                  |
| /11/01** | 1** | *5.5** | *2.5** |                                  |
+----------+-----+--------+--------+----------------------------------+
|          | **  | *      | *      | **TTB beamstop failure**         |
|          | 2** | *6.5** | *1.5** |                                  |
+----------+-----+--------+--------+----------------------------------+
|          | **  | **5**  | **3**  | **Magnets problems**             |
|          | 3** |        |        |                                  |
+----------+-----+--------+--------+----------------------------------+
| **01     | **  | **8**  | **0**  | **No incidents.**                |
| /12/01** | 1** |        |        |                                  |
+----------+-----+--------+--------+----------------------------------+
|          | **  | **2**  | **6**  | **TTB beamstop failure**         |
|          | 2** |        |        |                                  |
+----------+-----+--------+--------+----------------------------------+
|          | **  | **8**  | **0**  | **No incidents.**                |
|          | 3** |        |        |                                  |
+----------+-----+--------+--------+----------------------------------+
| **01     | **  | *      | *      | **Beam drift, magnets problems   |
| /13/01** | 1** | *7.5** | *0.5** | (AQ7&8)**                        |
+----------+-----+--------+--------+----------------------------------+
|          | **  | **7**  | **1**  | **Beam drift, magnets problems   |
|          | 2** |        |        | (AD4-9)**                        |
+----------+-----+--------+--------+----------------------------------+
|          | **  | **8**  | **0**  | ######### No incidents.          |
|          | 3** |        |        |                                  |
+----------+-----+--------+--------+----------------------------------+
| **01     | **  | **6**  | **2**  | **Magnets problems.**            |
| /14/01** | 1** |        |        |                                  |
+----------+-----+--------+--------+----------------------------------+
|          | **  | **8**  | **0**  | **Biology run end. Physics run   |
|          | 2** |        |        | starts.**                        |
+----------+-----+--------+--------+----------------------------------+
|          | **  | **8**  | **0**  | **No incidents.**                |
|          | 3** |        |        |                                  |
+----------+-----+--------+--------+----------------------------------+
| **01     | **  | **8**  | **0**  | ## No incidents.                 |
| /15/01** | 1** |        |        |                                  |
+----------+-----+--------+--------+----------------------------------+
|          | **  | **8**  | **0**  | ## No incidents.                 |
|          | 2** |        |        |                                  |
+----------+-----+--------+--------+----------------------------------+
|          | **  | **8**  | **0**  | **No incidents. BNL-7 end.**     |
|          | 3** |        |        |                                  |
+----------+-----+--------+--------+----------------------------------+

![](media/image5.wmf)

**BNL-7 EXPERIMENTERS AND RUN STATISTICS**

+------+----------+--------+--------+-------+--------+-------+-------+
| **   | **P      | **Ion  | **Beam | *     | **Dose | *     | **N   |
| Exp. | rincipal | &      | Time   | *Beam | Range  | *Dose | umber |
| ID** | Invest   | En     | Appr   | Time  | (      | /Rate | of    |
|      | igator** | ergy** | oved** | U     | cGy)** | (     | Samp  |
|      |          |        |        | sed** |        | cGy/m | les** |
|      |          |        |        |       |        | in)** |       |
+------+----------+--------+--------+-------+--------+-------+-------+
| B-1  | Zeitlin  | Fe, 1  | 32     | 37    | NA     | NA    | NA    |
|      |          | GeV/n  |        |       |        |       |       |
+------+----------+--------+--------+-------+--------+-------+-------+
| B-7  | Rabin    | Fe, 1  | 9.5    | 10    | 1      | 5     | 100   |
|      |          | GeV/n  |        |       | 00-150 | 0-150 |       |
+------+----------+--------+--------+-------+--------+-------+-------+
| B-12 | Hei      | Fe, 1  | 4      | 2     | 20-400 | 100   | 75    |
|      |          | GeV/n  |        |       |        |       |       |
+------+----------+--------+--------+-------+--------+-------+-------+
| ##   | Cooper   | Fe, 1  | 6      | 6     | 60-600 | 200   | 50    |
| B-18 |          | GeV/n  |        |       |        |       |       |
+------+----------+--------+--------+-------+--------+-------+-------+
| B-1  | Kr       | Fe, 1  | 12     | 10    | 31 -   | 5     | NA    |
| 9-20 | onenberg | GeV/n  |        |       | 189    | 0-100 |       |
+------+----------+--------+--------+-------+--------+-------+-------+
| B-25 | Evans    | Fe, 1  | 6      | 3     | 10-400 | 2     | 32    |
|      |          | GeV/n  |        |       |        | 0-100 |       |
+------+----------+--------+--------+-------+--------+-------+-------+
| B-29 | N        | Fe, 1  | 0      | 1     | NA     | NA    | NA    |
|      | atarajan | GeV/n  |        |       |        |       |       |
+------+----------+--------+--------+-------+--------+-------+-------+
| B-32 | Dicello  | Fe, 1  | 10     | 10    | 1 -    | 1-100 | 200   |
|      |          | GeV/n  |        |       | 100    |       |       |
+------+----------+--------+--------+-------+--------+-------+-------+
| B-39 | Burns    | Fe, 1  | 9      | 14    | 300    | 150   | 72    |
|      |          | GeV/n  |        |       |        |       |       |
+------+----------+--------+--------+-------+--------+-------+-------+
| B-42 | Barcel   | Fe, 1  | 5      | 4     | 50-200 | 100   | 50    |
|      | los-Hoff | GeV/n  |        |       |        |       |       |
+------+----------+--------+--------+-------+--------+-------+-------+
| B-43 | Nelson   | Fe, 1  | 2.5    | 4.5   | 10 -   | 100 - | 120   |
|      |          | GeV/n  |        |       | 200    | 200   |       |
+------+----------+--------+--------+-------+--------+-------+-------+
| B-44 | Durante  | Fe, 1  | 6      | 5     | 1000   | 1500  | 200   |
|      |          | GeV/n  |        |       | -40000 |       |       |
+------+----------+--------+--------+-------+--------+-------+-------+
| ##   | Setlow   | Fe, 1  | 2      | 2     | 30-100 | 5     | 200   |
| B-45 |          | GeV/n  |        |       |        | 0-100 |       |
+------+----------+--------+--------+-------+--------+-------+-------+
| ##   | Nelson   | Fe, 1  | 4      | 4.5   | 50-300 | 5     | 255   |
| B-47 |          | GeV/n  |        |       |        | 0-200 |       |
+------+----------+--------+--------+-------+--------+-------+-------+
| ##   | Green    | Fe, 1  | 0.7    | 1     | 10-300 | 5     | 30    |
| B-48 |          | GeV/n  |        |       |        | 0-200 |       |
+------+----------+--------+--------+-------+--------+-------+-------+
| B-51 | Murnane  | Fe, 1  | 3      | 2     | 400    | 200   | 50    |
|      |          | GeV/n  |        |       |        |       |       |
+------+----------+--------+--------+-------+--------+-------+-------+
| B-52 | Gerwitz  | Fe, 1  | 2      | 2.5   | NA     | NA    | NA    |
|      |          | GeV/n  |        |       |        |       |       |
+------+----------+--------+--------+-------+--------+-------+-------+
| B-53 | Lupton   | Fe, 1  | 1.5    | 2     | 100    | 100   | 20    |
|      |          | GeV/n  |        |       |        |       |       |
+------+----------+--------+--------+-------+--------+-------+-------+
| B-55 | Vazquez  | Fe, 1  | 6      | 6     | 10-200 | 3     | 200   |
|      |          | GeV/n  |        |       |        | 0-150 |       |
+------+----------+--------+--------+-------+--------+-------+-------+
| **   |          |        | *      | **    | **10-4 | **5   | **16  |
| Tota |          |        | *122.7 | 126.5 | 0000** | to    | 54+** |
| ls** |          |        | hr**   | hr**  |        | 200** |       |
+------+----------+--------+--------+-------+--------+-------+-------+

# BNL-7 PARTICIPANTS, EXPERIMENTAL SAMPLES AND ENDPOINTS

+----+--------------------+------------------+-------------------------+
| ** | **Participants**   | **Samples**      | **Endpoints**           |
| Ex |                    |                  |                         |
| p. |                    |                  |                         |
| ** |                    |                  |                         |
+----+--------------------+------------------+-------------------------+
| B  | Heavy Ion          | Solid state      | Heavy ion fragmentation |
| -1 | Fragmentation and  | detectors        |                         |
|    | Transport in       |                  | CR39 calibration        |
|    | Matter             |                  |                         |
|    |                    |                  |                         |
|    | **C. Zeitlin       |                  |                         |
|    | (PI)**             |                  |                         |
+----+--------------------+------------------+-------------------------+
| B  | Effects of         | Sprague-Dawley   | Neurological and        |
| -7 | Exposure to Heavy  | Rats             | neurochemical changes   |
|    | Ions.              |                  |                         |
|    |                    |                  |                         |
|    | **B. Rabin (PI)**  |                  |                         |
+----+--------------------+------------------+-------------------------+
| B- | Cytogenetic and    | Human bronquial  | Neoplastic              |
| 12 | Neoplastic         | epithelial cells | transformation,         |
|    | Transforming       | (BEP2D) and      | Differential gene       |
|    | Effects of Heavy   | breast cells     | expression, mutation    |
|    | Ions in Mammalian  | (MCF-10F)        | spectra by PCR          |
|    | Cells.             |                  |                         |
|    |                    |                  |                         |
|    | **T. Hei (PI)**    |                  |                         |
+----+--------------------+------------------+-------------------------+
| B- | DNA Repair and     | HeLa cells,      | Frequency of            |
| 18 | Early Dev. of      | human            | n                       |
|    | Chromosomal        | fibroblast,      | on-rejoined/misrejoined |
|    | Changes. Cytog.    |                  | PCC                     |
|    | Studies.           | XP-G cell line   |                         |
|    |                    |                  |                         |
|    | **P. Cooper (PI**) |                  |                         |
+----+--------------------+------------------+-------------------------+
| B- | Mutagenesis and    | Human lymphoid   | Apoptosis induction,    |
| 19 | Genomic            | cells (TK6) and  | mutat collection, cell  |
| B- | Inestability in    | WTK-bclX~L~      | killing and mutation,   |
| 20 | Human Lymphoid     |                  | DSB rejoining/fidelity  |
|    | cells              |                  |                         |
|    |                    |                  |                         |
|    | **A. Kronenberg    |                  |                         |
|    | (PI)**             |                  |                         |
+----+--------------------+------------------+-------------------------+
| B- | Induction of       | LY-S1 and LY-SR1 | Protective effects of   |
| 25 | Genomic            | murine           | WR1065 against          |
|    | Instability in     | lymphoblast,     | cytotoxicity and        |
|    | Human Lymphoblast  | human colon      | mutagenic effect.       |
|    |                    | cancer cells     | Detection by GFP        |
|    | **H. Evans (PI)**  |                  |                         |
+----+--------------------+------------------+-------------------------+
| B- | NF-KB Mediated     | Human macrophage | Gene expression         |
| 29 | Radio-Responsive   | cells (Mono Mac  |                         |
|    | Gene Transcription | 6)               |                         |
|    | after Heavy Ion    |                  |                         |
|    | Radiation          |                  |                         |
|    | Exposure.          |                  |                         |
|    |                    |                  |                         |
|    | **M. Natarajan     |                  |                         |
|    | (PI**)             |                  |                         |
+----+--------------------+------------------+-------------------------+
| B- | Tumor Formation in | Sprague-Dawley   | Tumor induction and     |
| 32 | Rat Mammary Glands | Rats, Rat and    | Tamoxifen protective    |
|    |                    | limphocytes, Min | effects and chromosomal |
|    | **J. Dicello       | Mouse            | aberrations             |
|    | (PI)**             |                  |                         |
+----+--------------------+------------------+-------------------------+
| B- | Tumor Induction by | Sprague-Dawley   | Skin tumor induction    |
| 39 | High-LET           | Rats             | and modulation by       |
|    | Radiation.         |                  | dietary retinyl         |
|    |                    |                  | actetate.               |
|    | **F. Burns (PI)**  |                  |                         |
+----+--------------------+------------------+-------------------------+
| B- | Particle           | Human mammary    | Microenvironment        |
| 42 | Irradiation of     | ephithelial      | changes, TGF-β and bFGF |
|    | Human Mammary      | cells (HMT 3522) | levels,                 |
|    | Epithelial Cells   |                  | immunocitochem.,        |
|    |                    |                  | apoptosis and           |
|    | **M.               |                  | neoplastic potential    |
|    | Barcellos-Hoff     |                  |                         |
|    | (PI)**             |                  |                         |
+----+--------------------+------------------+-------------------------+
| B- | Preliminary        | Mouse (C57B1/6)  | Neurological and        |
| 43 | Assessment of      |                  | immunological           |
|    | Immune System and  |                  | alterations             |
|    | behavioral         |                  |                         |
|    | Responses to       |                  |                         |
|    | Accelerated Iron   |                  |                         |
|    | Ion Exposure in    |                  |                         |
|    | the C57B1/6 Mouse. |                  |                         |
|    | **G. Nelson (PI)** |                  |                         |
+----+--------------------+------------------+-------------------------+
| B- | Influence of the   | AG1522 human     | DNA damage and repair.  |
| 44 | Shielding on the   | diploid foreskin | Shielding effects.      |
|    | Space rad.         | fibroblasts      |                         |
|    | Biological         |                  |                         |
|    | Effectiveness**.** |                  |                         |
|    |                    |                  |                         |
|    | **M. Durante       |                  |                         |
|    | (PI)**             |                  |                         |
+----+--------------------+------------------+-------------------------+
| B- | Germ Cell          | Male Medaka fish | Mutation induction      |
| 45 | Mutagenesis in     |                  |                         |
|    | Medaka Fish        |                  |                         |
|    | Following Exposure |                  |                         |
|    | to HZE particle    |                  |                         |
|    | radiation          |                  |                         |
|    |                    |                  |                         |
|    | **R. Setlow (PI)** |                  |                         |
+----+--------------------+------------------+-------------------------+
| B- | Genomic            | C57Bl/6 and      | Transmissible delayed   |
| 47 | Instability in     | CBA/Ca mice      | expression chrom        |
|    | Mouse              |                  | damage. Genomic         |
|    | Hematopoietic      |                  | instability, apoptosis  |
|    | Cells in Resp. to  |                  | and oxidative stress.   |
|    | Accelerated Iron   |                  |                         |
|    | Ion Exposure.      |                  |                         |
|    |                    |                  |                         |
|    | **G. Nelson (PI)** |                  |                         |
+----+--------------------+------------------+-------------------------+
| B- | Radiobiology of    | Thyroid cells    | Gene expression         |
| 48 | thyroid follicular |                  | alterations             |
|    | cells.             |                  |                         |
|    |                    |                  |                         |
|    | **L. Green (PI)**  |                  |                         |
+----+--------------------+------------------+-------------------------+
| B- | Particle-Ind.      | SC308H cells     | Survival, mutation      |
| 51 | Telomere Loss in   |                  | frequency, chromosomal  |
|    | Human cells.       |                  | changes and telomere    |
|    |                    |                  | status.                 |
|    | **J. Murnane       |                  |                         |
|    | (PI)**             |                  |                         |
+----+--------------------+------------------+-------------------------+
| B- | Effect of Deep     | TF-1 cells       | DNA damage (DSB and     |
| 52 | Space Radiation on |                  | clustered damages)      |
|    | Human              |                  |                         |
|    | Hematopoietic Stem |                  |                         |
|    | Cells.             |                  |                         |
|    |                    |                  |                         |
|    | **A. Gerwitz       |                  |                         |
|    | (PI)**             |                  |                         |
+----+--------------------+------------------+-------------------------+
| B- | Nutritional        | Sprague-Dawley   | Gene expression, tumor  |
| 53 | Countermeasures to | rats             | incidence.              |
|    | Radiation          |                  |                         |
|    | Exposure.          |                  |                         |
|    |                    |                  |                         |
|    | **J. Lupton (PI)** |                  |                         |
+----+--------------------+------------------+-------------------------+
| B- | Risk Assessment    | NT2 human neural | Survival, apoptosis and |
| 55 | and                | stem cells       | gene expression.        |
|    | Chemoprevention of |                  |                         |
|    | HZE-Induced CNS    |                  |                         |
|    | Damage             |                  |                         |
|    |                    |                  |                         |
|    | **M. Vazquez       |                  |                         |
|    | (PI)**             |                  |                         |
+----+--------------------+------------------+-------------------------+

**List of personnel that participated in the planning, organization and
execution of BNL-7 run**

**[BNL Management:]{.underline}**

-   Laboratory Director: **John Marburger**

-   Deputy Director for Science & Technology: **Peter Paul**

-   Associate Director for High Energy and Nuclear Physics**: Tom Kirk**

-   Associate Laboratory Director for Life Sciences: **Nora Volkow**

**[NASA Management:]{.underline}**

-   Headquarters: **Walter Schimmerling**

-   JSC: **Frank Cucinotta**

**[Scientific Advisory Committee:]{.underline}**

-   **Betsy Sutherland** (Chair), BNL

-   **Louis Pena,** BNL

-   **Richard Setlow,** BNL

-   **Joel Bedford,** CSU

-   **Les Braby,** PNL

-   **Charles Geard,** Columbia University

**[Collider Accelerator Department-AGS]{.underline}**

-   Chairman: **Derek Lowenstein**

-   Deputy Chairman: [**W.T.
    Weng**](http://www.ccd.bnl.gov/cgi-bin/ph/ns.bnl.gov?alias%3Dweng)

-   Associate Chair of Operations: [**A.J.
    McNerney**](http://www.ccd.bnl.gov/cgi-bin/ph/ns.bnl.gov?mcnerney)

-   Experimental Planning and Support Head: **Philip Pile**

-   Associate Chair for ES&H/Q.A: [E.
    Lessard](http://www.ccd.bnl.gov/cgi-bin/ph/ns.bnl.gov?alias%3Dlessard)

-   ES&H/Q.A : **Peter Cirnigliaro,**

-   Accelerator Division Head: **Thomas Roser**

-   Chief Electrical Engineer: [**J.
    Sandberg**](http://www.ccd.bnl.gov/cgi-bin/ph/ns.bnl.gov?alias%3Djsandberg)

-   Chief Mechanical Engineer: [**J.
    Tuozzolo**](http://www.ccd.bnl.gov/cgi-bin/ph/ns.bnl.gov?tuozzolo)

-   Accelerator Physicist lead by: **Leif Aherns**

-   Tanden Group leader: **Peter Thieberger**

-   Physics Support: **Yusef Makadisi**

-   CAD Components and instrumentation support: **David Gassner**

-   AGS Radiation Safety Committee: **Ken Reece**

-   C-A Dept Training Manager: **John Maraviglia**

-   AGS Control Section lead by: **Don Barton**

-   Liaison Engineering Group lead by: **Al Pendzick, David Williams**

-   Liaison physicist: **Don Lazarus**

-   RHIC&AGS Users Center: **Susan White-DePace, Angela Melocoton**

-   Mechanical Service Technicians led by: **Fred Kobasiuk**

-   Survey Group led by: **Frank Karl**

-   Beam Service Technicians led by**: Paul Valli**

-   Electronic Service Technicians led by: **Bill Anderson**

-   AGS Instrumentation Group led by: **Pete Stillman**

-   AGS Main Control Room and Operations led by: **Pete Ingrassia**

-   Health Physics Group led by: **Chuck Schaefer**

-   AGS Electricians led by **Bill Softye**

-   AGS Riggers led by: **Nick Cipolla**

-   Carpenter and Welder Support Service and Technical Support led by:
    **Roger Hubbard**

**[Medical Department:]{.underline}**

-   Dept. Chair: **L. Chang**

-   Medical Liaison: **Marcelo E. Vazquez**

-   Building manager: **W. Gunther**

-   Administration: **B. Coughlin-Byrne, and Donna Russo**

-   Animal Care Facilities: **Maryann Kershaw, Kerry Bonti, Chris
    Risland.**

-   Tissue Culture Facility manager**: Michael Makar**

-   Technical support**: Divine Adika, Katherine Conkling, Bae Pyatt**

-   Training Coordinator: **Ann Emrick**

```{=html}
<!-- -->
```
-   **[RCD]{.underline}**

-   **Kay Conkling**

-   **Dennis Ryan**

-   **Deana Buckallew**

-   **Jim Williams**

-   **Bob Colichio**

**[Safeguards & Security]{.underline}**

-   Sam Velazquez,

-   Ted Heuer

**[Plant Engineering:]{.underline}**

-   BLAF Custodian, **P. Abrams**

-   Plumbers: **B. McCafferty**

-   Painters/Carpenters: **B. Laakmann**

-   Electricians: **T. Baldwin**

[**Biology Department**:]{.underline}

-   Chairman: **Carl Anderson**

-   **Betsy Sutherland**

-   Administration: **Bonnie** **McGahern**

-   Cesiun Source Manager: **Richard Satkoulis**

**[Safety & Environmental Protection Division:]{.underline}**

-   Manager: **William Fortunato**

-   **Dean Atchison**

    **[Lawrence Berkeley National Laboratory:]{.underline}**

-   **Jack Miller**

-   **Lawrence Heilbronn**

-   **M. Nyman**

-   **R. P. Singh**

-   **W. Holley**