**January, 2006**

[CURRICULUM VITAE]{.underline}

[Name]{.underline}: Theresa M. Geiman, Ph.D.

[Citizenship]{.underline}: United States

[Education]{.underline}:

1993 B.A., Biochemistry and Biology, Western Maryland College,
Westminster, MD

1995 M.S., Biomedical Sciences, Hood College, Frederick, MD

2000 Ph.D., Molecular and Cellular Oncology, George Washington
University, Washington, DC

[Brief Chronology of Employment]{.underline}:

1993-1999 Graduate Student/Research Technician, Laboratory of Molecular
Immunoregulation, Intramural Research Support Program, NCI-Frederick
Cancer Research and Development Program, Frederick, MD

1999-2000 IRTA Postdoctoral Fellow, Laboratory of Molecular Embryology,
NICHD, NIH, Bethesda, MD

2000-2002 PRAT Fellow, Laboratory of Receptor Biology and Gene
Expression, Epigenetic Gene Regulation and Cancer Group, NCI, NIH,
Bethesda, MD

2002-2004 Research Fellow, Laboratory of Receptor Biology and Gene
Expression, Epigenetic Gene Regulation and Cancer Group, NCI, NIH,
Bethesda, MD

2004-Present Scientist I, Laboratory of Cancer Prevention,
NCI-Frederick, SAIC-Frederick

[Societies]{.underline}:

1992-1993 Beta Beta Beta, Honor Society in Biology

2001-2004 DNA Methylation Society

2001-present Women in Cancer Research (American Association for Cancer
Research) (Also, 1996-1998)

2001-present American Association for Cancer Research (Associate Member)

[Honors and Other Special Scientific Recognition]{.underline}:

1994 Certificate of Outstanding Performance, Biological Response
Modifiers Program BRMP) Award.

1998 Fort Detrick-NCI-FCRDC Spring Research Festival Poster Presentation
Award

2000 Pharmacology Research Associate (PRAT) Fellowship Award
(Competitive 2 year NIH fellowship)

2001 American Association for Cancer Research-AFLAC Scholar-in-Training
Award, travel award to \"Epigenetics of Cancer/Cancer and Chromosomal
Organization\" conferences

2002 The Fellows Award for Research Excellence (FARE Travel Award, NIH)

[Other Professional Activities]{.underline}:

2003 Chief Judge, Chromatin and Chromosomes Section, Fellows Award for
Research Excellence (FARE), NIH

2003-present NIH Women in Science Task Force (Advisory member), NIH
Office of the Director committee to investigate how to keep female
scientists in research science (helped in designing, administering, and
evaluating surveys for postdoctoral scientists)

[Invited Presentations]{.underline}:

> Purification and characterization of novel mammalian DNA
> methyltransferase 3B (DNMT3B) protein complexes linking multiple types
> of epigenetic modifiers. NCI Center for Cancer Research-Fellows and
> Young Investigator Retreat, Ocean City, MD; February 13, 2003.

# [Publications]{.underline}:

1.  Jarvis, C.D., Geiman, T., Vila-Storm, M.P., Osipovich, O., Akella,
    U., Candeias, S., Nathan, I., Durum, S.K., and Muegge, K.: A novel
    putative helicase produced in early murine lymphocytes. Gene 169:
    203-207, 1996.

2.  Durum, S.K., Lee, C.K., Geiman, T.M., Murphy, W.J., and Muegge, K.:
    CD16 cross-linking blocks rearrangement of the TCR beta locus and
    development of alpha beta T cells and induces development of NK
    cells from thymic progenitors. *J. Immunol.* 161: 3325-3329, 1998.

3.  Geiman, T.M., Durum, S.K., and Muegge, K.: Characterization of gene
    expression, genomic structure, and chromosomal localization of Hells
    (Lsh). *Genomics* 54: 477-483, 1998.

4.  Lee, C.K., Kim, K., Geiman, T.M., Murphy, W.J., Muegge, K., and
    Durum, S.K.: Cloning thymic precursor cells: Demonstration that
    individual pro-T1 cells have dual T-NK potential and individual
    pro-T2 cells have dual alpha/beta-gamma/delta T cell potential.
    *Cell Immunol.* 191: 139-144, 1999.

5.  Geiman, T.M., and Muegge, K.: Lsh, an SNF2/helicase family member,
    is required for proliferation of mature T lymphocytes. *Proc. Natl.
    Acad. Sci., U.S.A.* 97: 4772-4777, 2000.

6.  Guschin, D., Geiman, T.M., Kikyo, N., Tremethick, D.J., Wolffe,
    A.P., and Wade, P.A.: Multiple ISWI ATPase complexes from xenopus
    laevis. Functional conservation of an ACF/CHRAC homolog. *J. Biol.
    Chem.* 275: 35248-35255, 2000.

7.  Geiman, T.M., Tessarollo, L., Anver, M., Kopp, J.B., Ward, J.M., and
    Muegge, K.: Lsh, a SNF2 family member, is required for normal murine
    development. *Biochem. et Biophys. Acta.* 1526: 211-220, 2001.

8.  Dennis, K., Fan, T., Geiman, T., Yan, Q., and Muegge, K.: Lsh, a
    member of the SNF2 family, is required for genome-wide methylation.
    *Genes & Dev.* 15: 2940-2944, 2001.

9.  Tao, Q., Huang, H., Geiman, T.M., Lim, C.Y., Fu, L., Qiu, G-H., and
    Robertson, K.D.: Defective de novo methylation of viral and cellular
    DNA sequences in ICF syndrome cells. *Hum. Mol. Genet.* 11:
    2091-2102, 2002.

10. Geiman, T.M., and Robertson, K.D.: Methylation. *Genetics*,
    Robinson, R., Ed. New York: McMillan Reference USA, 2002.

11. Geiman, T.M., Sankpal, U.T., Robertson, A.K., Zhao, Y., Zhao, Y.,
    and Robertson, K.D.: DNMT3B interacts with hSNF2H chromatin
    remodeling enzyme, HDACs 1 and 2, and components of the histone
    methylation system. *Biochem. Biophys. Res. Commun.* 318: 544-555,
    2004.

12. Geiman, T.M., Sankpal, U.T., Robertson, A.K, Chen, Y., Mazumdar, M.,
    Kim, W., Yokomori, K., Zhao, Y., and Robertson, K.D.: Isolation and
    characterization of a novel DNA methyltransferase complex linking
    DNMT3B with components of the mitotic chromosome condensation
    machinery. *Nucleic Acids Res.* 32: 2716-2729, 2004.

13. Robertson, A.K, Geiman, T.M., Sankpal, U.T., Hager, G.L., Robertson,
    K.D.: Effects of chromatin structure on the enzymatic and DNA
    binding functions of DNA methyltransferases DNMT1 and Dnmt3a in
    vitro. *Biochem. Biophys. Res. Comm.* 322: 110-118, 2004.

14. Heming, Z., Geiman, T.M., Xi, S., Schmidtmann, A., Jiang, Q., Chen,
    T., Li, E., and Muegge, K. Lsh is involved in de novo methylation of
    DNA. *[Embo J.]{.underline}* 2006 Jan 5; \[Epub ahead of print\].

[Manuscripts Submitted]{.underline}:

[Reviews]{.underline}:

1.  Geiman, T.M. and Robertson, K.D.: Chromatin Remodeling, histone
    modifications, and DNA methylation - How does it all fit together?
    *J. Cell. Biochem.* 87: 117-125, 2002.

[Abstracts]{.underline}:

1.  Geiman, T.M., Durum, S.K., and Muegge, K.: LSH, a novel helicase
    family member, preferentially expressed in lymphoid tissue.
    *Experimental Biology '99 (FASEB)*, 1999.

2.  Geiman, T.M., Ryan, R.F., Ling, Y., and Robertson, K.D.:
    Identification of novel de novo DNA methyltransferase complexes
    linking DNA methylation, histone deacetylation, and ATP-dependent
    chromatin remodeling. *Epigenetics of Cancer/Cancer and Chromosomal
    Organization AACR Conferences*, 2001.