**UNITED STATES ENVIRONMENTAL PROTECTION AGENCY**

**WASHINGTON, D.C. 20460**

**OFFICE OF**

**PREVENTION, PESTICIDES**

**AND TOXIC SUBSTANCES**

**[MEMORANDUM]{.underline}**

DATE: June 14, 2006

SUBJECT: Dimethenamid-p Acute and Chronic Dietary Exposure Assessments
for the Section 3 Registration Action.

> PC Code: 129051
>
> DP Num: 318282

REVIEWER: Shaja R. Brothers, Environmental Protection Specialist

> Risk Integration Minor Use and Emergency Response Branch/Registration
> Division (7505P)

THROUGH: William Cutchin, Chemist

ARIA

Technical Review Branch/Registration Division (7505P)

> Jose Morales, Chemist
>
> Leung Cheng, Chemist

Health Effects Division (7509P)

TO: Christina Swartz, Branch Chief

Registration Action Branch 2

Health Effects Division (7509P)

**Executive Summary**

Acute and chronic dietary risk assessments were conducted using the
Dietary Exposure Evaluation Model (DEEM-FCID, Version 2.03), which uses
food consumption data from the USDA's Continuing Surveys of Food Intakes
by Individuals (CSFII) from 1994-1996 and 1998. The analyses were
performed to support Section 3 requests for the use of dimethenamid-p on
bulb vegetable commodities (PP# Number range CHAPTER4E6844).

[Acute Dietary Exposure Results and Characterization]{.underline}

An acute Tier 1 dietary analysis (assuming tolerance level residues)
default processing factors, and 100 percent crop treated (%CT)
information was conducted for dimethenamid-p. The highest drinking water
estimate for acute exposure, 49 ppb, was used in the analysis. This
analysis incorporates all current, and proposed tolerances for
dimethenamid-p as of October 28, 2005. Risk estimates due to acute
dietary exposure from food using the Tier 1 analysis for the

subgroup Females 13-50 are less than 1% of the aPAD, which is below the
Agency\'s level of concern.

[Chronic Dietary Exposure Results and Characterization]{.underline}

A chronic Tier 1 dietary analysis (assuming tolerance level residues)
default processing factors, and 100 percent crop treated (%CT)
information was conducted for dimethenamid-p. The highest drinking water
estimate for chronic exposure, 7.9 ppb, was used in the analysis. This
analysis incorporates all current, and proposed tolerances for
dimethenamid-p as of October 28, 2005. Risk estimates due to chronic
dietary exposure from food using the Tier 1 analysis for the subgroup,
all infants (\< 1 year old), utilized 1% or less of the aPAD, which is
below the Agency\'s level of concern.

[Cancer Dietary Exposure Results and Characterization]{.underline}

Dimethenamid-p is a category C possible human carcinogen not requiring
any type of quantitative cancer risk assessment.

**I. Introduction**

Dietary risk assessment incorporates both exposure and toxicity of a
given pesticide. For acute and chronic assessments, the risk is
expressed as a percentage of a maximum acceptable dose (i.e., the dose
which HED has concluded will result in no unreasonable adverse health
effects). This dose is referred to as the population adjusted dose
(PAD). The PAD is equivalent to the Reference Dose (RfD) divided by the
special FQPA Safety Factor.

For acute and non-cancer chronic exposures, HED is concerned when
estimated dietary risk exceeds 100% of the PAD. HED is generally
concerned when estimated cancer risk exceeds one in one million (i.e.,
the risk exceeds 1 x 10^-6^). References which discuss the acute and
chronic risk assessments in more detail are available on the
EPA/pesticides web site: "Available Information on Assessing Exposure
from Pesticides, A User's Guide," 6/21/2000, web link:
[http://www.epa.gov/fedrgstr/EPA‑PEST/2000/July/Day‑12/6061.pdf]{.underline}
; or see SOP 99.6 (8/20/99).

The most recent dietary risk assessment for dimethenamid-p was conducted
by C. Swartz

*et. al.* (1/24/2006, D314487).

**II. Residue Information**

Dimethenamid-p:
2-chloro-N-\[(1-methyl-2-methoxy)ethyl\]-N-(2,4-dimethyl-thien-3-yl)-acetamide
is a synthetic herbicide for which tolerances have been established (40
CFR 180.464) at 0.01 ppm in bean, dry, seed; beet, garden, roots; beet,
garden, tops; beet, sugar, dried pulp; beet, sugar, molasses; beet,
sugar, roots; beet, sugar, tops; corn, field, forage; corn, field,
grain; corn, field, stover; corn, pop, forage; corn, pop, grain; corn,
pop, stover; corn sweet, forage; corn, sweet, kernel plus cobs with husk
removed; corn, sweet, stover; garlic; horseradish; onion, dry bulb;
peanut, hay; peanut, nutmeat; shallot, bulb; sorghum, grain; sorghum,
grain, forage; sorghum, grain, stover; soybean, seed; and tuberous and
corm vegetables. The residue of concern for enforcement and risk
assessment purposes is dimethenamid-p *per se*. As part of the current
petition, ARIA recommended establishing the permanent tolerances below 1
for residues of dimethenamid-p:

  -------------------------------------- --------------------------------
  Commodity                              Recommended Tolerance (ppm)

  Onion, green                           0.01

  Leek                                   0.01

  Onion, Welsh                           0.01

  Shallot, fresh leaves                  0.01
  -------------------------------------- --------------------------------

The following conservative assumptions were made for the chronic dietary
analysis: HED recommended tolerance level residues (associated with the
current petition and previously registered uses), DEEM default
processing factors for all RACs, and assumed all RACs were 100% treated
with dimethenamid-p.

Drinking water concentrations have been predicted using a standard
Georgia onion scenario as a surrogate for use on all crops, using
acceptable environmental fate and transport data submitted to the
Agency. Tier II surface water concentrations are predicted by the
PRZM/EXAMS model at 49 ug/L for acute exposure, 7.9 ug/L for non-cancer
chronic exposure, and 5.1 ug/L for overall chronic exposure. Ground
water concentrations of 0.42 ug/L were predicted by the Tier I model,
SCIGROW. This assessment is for the parent compound *only*.

**III** **Program and Consumption Information**

**IIIa. DEEM-FCID™ Program and Consumption Information**

Dimethenamid-p acute and chronic dietary exposure assessments were
conducted using the Dietary Exposure Evaluation Model software with the
Food Commodity Intake Database (DEEM-FCID™, Version 2.03), which
incorporates consumption data from USDA's Continuing Surveys of Food
Intakes by Individuals (CSFII), 1994-1996 and 1998. The 1994-96, 98 data
are based on the reported consumption of more than 20,000 individuals
over two non-consecutive survey days. Foods "as consumed" (e.g., apple
pie) are linked to EPA-defined food commodities (e.g. apples, peeled
fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or
N/S, baked) using publicly available recipe translation files developed
jointly by USDA/ARS and EPA. For chronic exposure assessment,
consumption data are averaged for the entire U.S. population and within
population subgroups, but for acute exposure assessment are retained as
individual consumption events. Based on analysis of the 1994-96, 98
CSFII consumption data, which took into account dietary patterns and
survey respondents, HED concluded that it is most appropriate to report
risk for the following population subgroups: the general U.S.
population, all infants (\<1 year old), children 1-2, children 3-5,
children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50+
years old.

For chronic dietary exposure assessment, an estimate of the residue
level in each food or food-form (e.g., orange or orange juice) on the
food commodity residue list is multiplied by the average daily
consumption estimate for that food/food form to produce a residue intake
estimate. The resulting residue intake estimate for each food/food form
is summed with the residue intake estimates for all other food/food
forms on the commodity residue list to arrive at the total average
estimated exposure. Exposure is expressed in mg/kg body weight/day and
as a percent of the cPAD. This procedure is performed for each
population subgroup.

For acute exposure assessments, individual one-day food consumption data
are used on an individual-by-individual basis. The reported consumption
amounts of each food item can be multiplied by a residue point estimate
and summed to obtain a total daily pesticide exposure for a
deterministic exposure assessment, or "matched" in multiple random
pairings with residue values and then summed in a probabilistic
assessment. The resulting distribution of exposures is expressed as a
percentage of the aPAD on both a user (i.e., only those who reported
eating relevant commodities/food forms) and a per-capita (i.e., those
who reported eating the relevant commodities as well as those who did
not) basis. In accordance with HED policy, per capita exposure and risk
are reported for all tiers of analysis. However, for tiers 1 and 2, any
significant differences in user vs. per capita exposure and risk are
specifically identified and noted in the risk assessment.

**IV. Toxicological Information**

[FQPA safety factor]{.underline}. Based on the hazard data, HED
recommended the special FQPA SF be reduced to 1X because there are low
concerns, and no residual uncertainties with regard to pre- and/or
postnatal toxicity. Also, based on the quality of the exposure data, the
dimethenamid-p risk assessment team recommended that the special FQPA SF
be reduced to 1X. The recommendation is based on the following: 1) the
dietary food exposure assessment utilizes proposed tolerance level
residues and 100% CT information for all commodities. By using these
screening-level assessments, acute and chronic exposure will not be
underestimated, and 2) the dietary drinking water assessment (Tier 2
estimates) utilizes values generated by model and associated modeling
parameters which are designed to provide health protective, high-end
estimates of water concentrations.

[Acute Dietary Exposure]{.underline}. NOAEL is 75 mg/kg/day. LOAEL is
150 mg/kg/day based on developmental effects of increased resorptions,
implantation loss and angulated hyoid alae. The resorptions and post
implantation loss is presumed to be a single dose effect. The
developmental endpoint is appropriate for females 13-49 and is of the
appropriate duration. The endpoint is supported by a range-finding study
in rats with \[S\]-dimethenamid-P, which showed increased resorptions at
400 mg/kg/day.

An appropriate acute endpoint attributable to a single dose was not
available for the general population in the toxicity data base including
the developmental toxicity studies.

[Chronic Dietary Exposure]{.underline}. NOAEL is 5.1/6.8 mg/kg/day for
male/female. The LOAEL is 36/49 mg/kg/day for male/female based on
decreased body weight and body weight gain from week 1-10 and week
10-104 in both sexes, and at termination increased microscopic hepatic
lesions in both sexes.

+------------+-------------+---------------+-------------------------+
| **Table 1. |             |               |                         |
| Summary of |             |               |                         |
| Tox        |             |               |                         |
| icological |             |               |                         |
| Dose and   |             |               |                         |
| Endpoints  |             |               |                         |
| for**      |             |               |                         |
|            |             |               |                         |
| **Dime     |             |               |                         |
| thenamid-p |             |               |                         |
| for Use in |             |               |                         |
| Dietary    |             |               |                         |
| Exposure   |             |               |                         |
| As         |             |               |                         |
| sessment** |             |               |                         |
+============+=============+===============+=========================+
| **         | **Dose Used | **Special     | **Study and             |
| Exposure** | in Risk     | FQPA SF and   | Toxicological Effects** |
|            | Assessment, | Level of      |                         |
| **         | UF**        | Concern for   |                         |
| Scenario** |             | Risk          |                         |
|            |             | Assessment**  |                         |
+------------+-------------+---------------+-------------------------+
| Acute      | NOAEL = 75  | FQPA SF = 1X  | Developmental Toxicity  |
| Dietary    | mg/kg/day   |               | in rabbits              |
|            |             | aPAD = [acute |                         |
| (Females   | UF = 100    | RfD           | Maternal LOAEL = 150    |
| 13-49      |             | ]{.underline} | mg/kg/day based on      |
| years of   | Acute RfD = |               | abortions and decreased |
| age)       | 0.75        | FQPA SF       | body weight gain and    |
|            | mg/kg/day   |               | food consumption.       |
| Based on   |             | = 0.75        |                         |
| \[RS\]     |             | mg/kg/day     | Developmental; LOAEL =  |
| data       |             |               | 150 mg/kg/day based on  |
|            |             |               | post-implantation loss  |
+------------+-------------+---------------+-------------------------+
| Acute      | Not         |               |                         |
| Dietary    | Applicable  |               |                         |
|            |             |               |                         |
| (General   | No studies  |               |                         |
| population | identify an |               |                         |
| including  | acute       |               |                         |
| infants    | hazard      |               |                         |
| and        | (dose and   |               |                         |
| children)  | endpoint)   |               |                         |
|            | based on a  |               |                         |
|            | single oral |               |                         |
|            | exposure    |               |                         |
|            | (dose)      |               |                         |
+------------+-------------+---------------+-------------------------+
| Chronic    | NOAEL= 5    | FQPA SF = 1X  | Chronic/carcinogenicity |
| Dietary    | mg/kg/day   |               | rats                    |
|            |             | cPAD =        |                         |
| (All       | UF = 100    |               | LOAEL = M/F; 36/49      |
| po         |             | [chronic      | mg/kg/day based on      |
| pulations) | Chronic RfD | RfD           | decreased body weight   |
|            | =           | ]{.underline} | and body weight gain in |
| Based on   |             |               | both sexes, increased   |
| \[RS\]     | 0.05        | FQPA SF       | food conversion ratios  |
| data       | mg/kg/day   |               | in females, and         |
|            |             | = 0.05        | increased microscopic   |
|            |             | mg/kg/day     | hepatic lesions in both |
|            |             |               | sexes.                  |
+------------+-------------+---------------+-------------------------+
| Carci      | "C"         |               |                         |
| nogenicity | Possible    |               |                         |
|            | human       |               |                         |
| Based on   | carcinogen. |               |                         |
| \[RS\]     | (No Q~1~\*) |               |                         |
| data       |             |               |                         |
+------------+-------------+---------------+-------------------------+

**V. Results/Discussion**

As stated above, for acute and chronic assessments, HED is concerned
when dietary risk exceeds 100% of the PAD. The DEEM-FCID analyses
estimate the dietary exposure of the U.S. population and various
population subgroups. The results reported are for the general U.S.
Population, all infants (\<1 year old), children 1-2, children 3-5,
children 6-12, youth 13-19, females 13-49, adults 20-49, and adults 50+
years. Cancer risk is determined for the general U.S. population only.

[Results of Acute Dietary Exposure Analysis]{.underline}

Results are reported at the 95th percentile of exposure because the
assessment incorporated tolerance level residues and 100% CT
assumptions. The estimated acute (one day) aggregate food and water
exposure of females 13-49 years old is less than 1% of the
dimethenamid-p aPAD.

+--------------------------+------------+------------+---------------+
| **Table 2. Results of    |            |            |               |
| Acute Dietary Exposure   |            |            |               |
| Analysis at the 95^th^   |            |            |               |
| Percentile of Exposure** |            |            |               |
+==========================+============+============+===============+
| Population Subgroup      | aPAD       | Exposure   | \% aPAD       |
|                          |            | (          |               |
|                          | (          | mg/kg/day) |               |
|                          | mg/kg/day) |            |               |
+--------------------------+------------+------------+---------------+
| Females 13-50            | 0.75       | 0.002417   | \< 1          |
+--------------------------+------------+------------+---------------+

[Results of Chronic Dietary Exposure Analysis]{.underline}

The estimated chronic aggregate food and water dietary risk estimates
for all population subgroups utilized 1% or less of the dimethenamid-p
cPAD (0.05 mg/kg/day).

+---------------------------+------------+------------+---------------+
| **Table 3. Results of     |            |            |               |
| Chronic Dietary Exposure  |            |            |               |
| Analysis**                |            |            |               |
+===========================+============+============+===============+
| **Population Subgroup**   | **cPAD**   | **Exposure | **% cPAD**    |
|                           |            | (mg        |               |
|                           | **(mg      | /kg/day)** |               |
|                           | /kg/day)** |            |               |
+---------------------------+------------+------------+---------------+
| General U.S. Population   | 0.05       | 0.000205   | \<1           |
+---------------------------+------------+------------+---------------+
| All Infants (\< 1 year    | 0.05       | 0.000605   | 1             |
| old)                      |            |            |               |
+---------------------------+------------+------------+---------------+
| Children 1-2 years old    | 0.05       | 0.000329   | \<1           |
+---------------------------+------------+------------+---------------+
| Children 3-5 years old    | 0.05       | 0.000316   | \<1           |
+---------------------------+------------+------------+---------------+
| Children 6-12 years old   | 0.05       | 0.000221   | \<1           |
+---------------------------+------------+------------+---------------+
| Youth 13-19 years old     | 0.05       | 0.000163   | \<1           |
+---------------------------+------------+------------+---------------+
| Adults 20-49 years old    | 0.05       | 0.000187   | \<1           |
+---------------------------+------------+------------+---------------+
| Females 13-49 years old   | 0.05       | 0.000185   | \<1           |
+---------------------------+------------+------------+---------------+
| Adults 50+ years old      | 0.05       | 0.000187   | \<1           |
+---------------------------+------------+------------+---------------+

[Results of Cancer Dietary Exposure Analysis]{.underline}

Dimethenamid is a category C possible human carcinogen not requiring any
type of quantitative cancer risk assessment.

**VII. Conclusions**

The acute dietary exposure and risk assessment indicates that for all
included commodities, the acute dietary risk estimates are below HED's
level of concern (\<100% aPAD) for females 13-50 at less than 1% of the
aPAD. Additional refinement using % CT data and additional processing
factors would result in even lower exposure estimates.

The chronic dietary exposure and risk assessment also indicates that for
all included commodities, the chronic dietary risk estimates are below
HED's level of concern (\<100% cPAD) for the general U.S. population
(\<1% of the cPAD) and all population subgroups. The chronic dietary
exposure estimate for the highest exposed population subgroup (all
infants \< 1 year old) is 1% or less of the cPAD. Refinement using ARs,
processing factors, and % CT data would result in even lower chronic
exposure estimates.

**VIII. List of Attachments**

Attachment 1: Acute Input File

Attachment 2: Acute Output File

Attachment 3: Chronic Input File

Attachment 4: Chronic Output File

Attachment 1: Acute Input File

Filename: E:\\working\\Dimetheneamid\\120051a.R98 Chemical:
Dimethenamide

RfD(Chronic): .05 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .75 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 02-17-2006/19:50:30/8 Program ver. 2.03

\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--

EPA Crop Def Res Adj.Factors Comment

Code Grp Commodity Name (ppm) #1 #2

\-\-\-\-\-\-\-- \-\-\--
\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--
\-\-\-\-\-\-\-\-\-- \-\-\-\-\-- \-\-\-\-\-- \-\-\-\-\-\--

95002630 O Peanut 0.010000 1.000 1.000

95002640 O Peanut, butter 0.010000 1.000 1.000

95002650 O Peanut, oil 0.010000 1.000 1.000

86010000 O Water, direct, all sources 0.049000 1.000 1.000

86020000 O Water, indirect, all sources 0.049000 1.000 1.000

01030150 1CD Arrowroot, flour 0.010000 1.000 1.000

01030151 1CD Arrowroot, flour-babyfood 0.010000 1.000 1.000

01030170 1CD Artichoke, Jerusalem 0.010000 1.000 1.000

01010500 1AB Beet, garden, roots 0.010000 1.000 1.000

01010501 1AB Beet, garden, roots-babyfood 0.010000 1.000 1.000

01010520 1A Beet, sugar 0.010000 1.000 1.000

01010521 1A Beet, sugar-babyfood 0.010000 1.000 1.000

01010530 1A Beet, sugar, molasses 0.010000 1.000 1.000

01010531 1A Beet, sugar, molasses-babyfood 0.010000 1.000 1.000

01030820 1CD Cassava 0.010000 1.000 1.000

01030821 1CD Cassava-babyfood 0.010000 1.000 1.000

01031390 1CD Dasheen, corm 0.010000 1.000 1.000

01031660 1CD Ginger 0.010000 1.000 1.000

01031661 1CD Ginger-babyfood 0.010000 1.000 1.000

01031670 1CD Ginger, dried 0.010000 1.000 1.000

01011900 1AB Horseradish 0.010000 1.000 1.000

01032960 1C Potato, chips 0.010000 1.000 1.000

01032970 1C Potato, dry (granules/ flakes) 0.010000 1.000 1.000

01032971 1C Potato, dry (granules/ flakes)-b 0.010000 1.000 1.000

01032980 1C Potato, flour 0.010000 1.000 1.000

01032981 1C Potato, flour-babyfood 0.010000 1.000 1.000

01032990 1C Potato, tuber, w/peel 0.010000 1.000 1.000

01032991 1C Potato, tuber, w/peel-babyfood 0.010000 1.000 1.000

01033000 1C Potato, tuber, w/o peel 0.010000 1.000 1.000

01033001 1C Potato, tuber, w/o peel-babyfood 0.010000 1.000 1.000

01033660 1CD Sweet potato 0.010000 1.000 1.000

01033661 1CD Sweet potato-babyfood 0.010000 1.000 1.000

01033710 1CD Tanier, corm 0.010000 1.000 1.000

01033870 1CD Turmeric 0.010000 1.000 1.000

01034060 1CD Yam, true 0.010000 1.000 1.000

01034070 1CD Yam bean 0.010000 1.000 1.000

02000510 2 Beet, garden, tops 0.010000 1.000 1.000

02001400 2 Dasheen, leaves 0.010000 1.000 1.000

03001640 3 Garlic 0.010000 1.000 1.000

03001650 3 Garlic, dried 0.010000 1.000 1.000

03001651 3 Garlic, dried-babyfood 0.010000 1.000 1.000

03001980 3 Leek 0.010000 1.000 1.000

03002370 3 Onion, dry bulb 0.010000 1.000 1.000

03002371 3 Onion, dry bulb-babyfood 0.010000 1.000 1.000

03002380 3 Onion, dry bulb, dried 0.010000 1.000 1.000

03002381 3 Onion, dry bulb, dried-babyfood 0.010000 1.000 1.000

03002390 3 Onion, green 0.010000 1.000 1.000

03003380 3 Shallot 0.010000 1.000 1.000

06030300 6C Bean, black, seed 0.010000 1.000 1.000

06030320 6C Bean, broad, seed 0.010000 1.000 1.000

06030340 6C Bean, cowpea, seed 0.010000 1.000 1.000

06030350 6C Bean, great northern, seed 0.010000 1.000 1.000

06030360 6C Bean, kidney, seed 0.010000 1.000 1.000

06030380 6C Bean, lima, seed 0.010000 1.000 1.000

06030390 6C Bean, mung, seed 0.010000 1.000 1.000

06030400 6C Bean, navy, seed 0.010000 1.000 1.000

06030410 6C Bean, pink, seed 0.010000 1.000 1.000

06030420 6C Bean, pinto, seed 0.010000 1.000 1.000

06030980 6C Chickpea, seed 0.010000 1.000 1.000

06030981 6C Chickpea, seed-babyfood 0.010000 1.000 1.000

06030990 6C Chickpea, flour 0.010000 1.000 1.000

06003470 6 Soybean, seed 0.010000 1.000 1.000

06003480 6 Soybean, flour 0.010000 1.000 1.000

06003481 6 Soybean, flour-babyfood 0.010000 1.000 1.000

06003490 6 Soybean, soy milk 0.010000 1.000 1.000

06003491 6 Soybean, soy milk-babyfood or in 0.010000 1.000 1.000

06003500 6 Soybean, oil 0.010000 1.000 1.000

06003501 6 Soybean, oil-babyfood 0.010000 1.000 1.000

09023570 9B Squash, winter 0.010000 1.000 1.000

09023571 9B Squash, winter-babyfood 0.010000 1.000 1.000

15001200 15 Corn, field, flour 0.010000 1.000 1.000

15001201 15 Corn, field, flour-babyfood 0.010000 1.000 1.000

15001210 15 Corn, field, meal 0.010000 1.000 1.000

15001211 15 Corn, field, meal-babyfood 0.010000 1.000 1.000

15001220 15 Corn, field, bran 0.010000 1.000 1.000

15001230 15 Corn, field, starch 0.010000 1.000 1.000

15001231 15 Corn, field, starch-babyfood 0.010000 1.000 1.000

15001240 15 Corn, field, syrup 0.010000 1.000 1.000

15001241 15 Corn, field, syrup-babyfood 0.010000 1.000 1.000

15001250 15 Corn, field, oil 0.010000 1.000 1.000

15001251 15 Corn, field, oil-babyfood 0.010000 1.000 1.000

15001260 15 Corn, pop 0.010000 1.000 1.000

15001270 15 Corn, sweet 0.010000 1.000 1.000

15001271 15 Corn, sweet-babyfood 0.010000 1.000 1.000

15003440 15 Sorghum, grain 0.010000 1.000 1.000

Attachment 2: Acute Output File

U.S. Environmental Protection Agency Ver. 2.02

DEEM-FCID ACUTE Analysis for DIMETHENAMIDE (1994-98 data)

Residue file: 120051a.R98 Adjustment factor #2 NOT used.

Analysis Date: 06-14-2006/15:20:33 Residue file dated:
06-14-2006/15:18:10/8

Daily totals for food and foodform consumption used.

Run Comment: \"\"

===============================================================================

Summary calculations (per capita):

95th Percentile 99th Percentile 99.9th Percentile

Exposure % aRfD Exposure % aRfD Exposure % aRfD

\-\-\-\-\-\-\-\-\-- \-\-\-\-\-\-\-- \-\-\-\-\-\-\-\-\-- \-\-\-\-\-\-\--
\-\-\-\-\-\-\-\-\-- \-\-\-\-\-\-\--

Females 13-49 yrs:

0.002417 0.32 0.003843 0.51 0.006859 0.91

Attachment 3: Chronic Input File

Filename: E:\\working\\Dimetheneamid\\120051c.R98 Chemical:
Dimethenamide

RfD(Chronic): .05 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .75 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 06-14-2006/15:15:23/8 Program ver. 2.03

\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--

EPA Crop Def Res Adj.Factors Comment

Code Grp Commodity Name (ppm) #1 #2

\-\-\-\-\-\-\-- \-\-\--
\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--
\-\-\-\-\-\-\-\-\-- \-\-\-\-\-- \-\-\-\-\-- \-\-\-\-\-\--

95002630 O Peanut 0.010000 1.000 1.000

95002640 O Peanut, butter 0.010000 1.000 1.000

95002650 O Peanut, oil 0.010000 1.000 1.000

86010000 O Water, direct, all sources 0.008000 1.000 1.000

86020000 O Water, indirect, all sources 0.008000 1.000 1.000

01030150 1CD Arrowroot, flour 0.010000 1.000 1.000

01030151 1CD Arrowroot, flour-babyfood 0.010000 1.000 1.000

01030170 1CD Artichoke, Jerusalem 0.010000 1.000 1.000

01010500 1AB Beet, garden, roots 0.010000 1.000 1.000

01010501 1AB Beet, garden, roots-babyfood 0.010000 1.000 1.000

01010520 1A Beet, sugar 0.010000 1.000 1.000

01010521 1A Beet, sugar-babyfood 0.010000 1.000 1.000

01010530 1A Beet, sugar, molasses 0.010000 1.000 1.000

01010531 1A Beet, sugar, molasses-babyfood 0.010000 1.000 1.000

01030820 1CD Cassava 0.010000 1.000 1.000

01030821 1CD Cassava-babyfood 0.010000 1.000 1.000

01031390 1CD Dasheen, corm 0.010000 1.000 1.000

01031660 1CD Ginger 0.010000 1.000 1.000

01031661 1CD Ginger-babyfood 0.010000 1.000 1.000

01031670 1CD Ginger, dried 0.010000 1.000 1.000

01011900 1AB Horseradish 0.010000 1.000 1.000

01032960 1C Potato, chips 0.010000 1.000 1.000

01032970 1C Potato, dry (granules/ flakes) 0.010000 1.000 1.000

01032971 1C Potato, dry (granules/ flakes)-b 0.010000 1.000 1.000

01032980 1C Potato, flour 0.010000 1.000 1.000

01032981 1C Potato, flour-babyfood 0.010000 1.000 1.000

01032990 1C Potato, tuber, w/peel 0.010000 1.000 1.000

01032991 1C Potato, tuber, w/peel-babyfood 0.010000 1.000 1.000

01033000 1C Potato, tuber, w/o peel 0.010000 1.000 1.000

01033001 1C Potato, tuber, w/o peel-babyfood 0.010000 1.000 1.000

01033660 1CD Sweet potato 0.010000 1.000 1.000

01033661 1CD Sweet potato-babyfood 0.010000 1.000 1.000

01033710 1CD Tanier, corm 0.010000 1.000 1.000

01033870 1CD Turmeric 0.010000 1.000 1.000

01034060 1CD Yam, true 0.010000 1.000 1.000

01034070 1CD Yam bean 0.010000 1.000 1.000

02000510 2 Beet, garden, tops 0.010000 1.000 1.000

02001400 2 Dasheen, leaves 0.010000 1.000 1.000

03001640 3 Garlic 0.010000 1.000 1.000

03001650 3 Garlic, dried 0.010000 1.000 1.000

03001651 3 Garlic, dried-babyfood 0.010000 1.000 1.000

03001980 3 Leek 0.010000 1.000 1.000

03002370 3 Onion, dry bulb 0.010000 1.000 1.000

03002371 3 Onion, dry bulb-babyfood 0.010000 1.000 1.000

03002380 3 Onion, dry bulb, dried 0.010000 1.000 1.000

03002381 3 Onion, dry bulb, dried-babyfood 0.010000 1.000 1.000

03002390 3 Onion, green 0.010000 1.000 1.000

03003380 3 Shallot 0.010000 1.000 1.000

06030300 6C Bean, black, seed 0.010000 1.000 1.000

06030320 6C Bean, broad, seed 0.010000 1.000 1.000

06030340 6C Bean, cowpea, seed 0.010000 1.000 1.000

06030350 6C Bean, great northern, seed 0.010000 1.000 1.000

06030360 6C Bean, kidney, seed 0.010000 1.000 1.000

06030380 6C Bean, lima, seed 0.010000 1.000 1.000

06030390 6C Bean, mung, seed 0.010000 1.000 1.000

06030400 6C Bean, navy, seed 0.010000 1.000 1.000

06030410 6C Bean, pink, seed 0.010000 1.000 1.000

06030420 6C Bean, pinto, seed 0.010000 1.000 1.000

06030980 6C Chickpea, seed 0.010000 1.000 1.000

06030981 6C Chickpea, seed-babyfood 0.010000 1.000 1.000

06030990 6C Chickpea, flour 0.010000 1.000 1.000

06003470 6 Soybean, seed 0.010000 1.000 1.000

06003480 6 Soybean, flour 0.010000 1.000 1.000

06003481 6 Soybean, flour-babyfood 0.010000 1.000 1.000

06003490 6 Soybean, soy milk 0.010000 1.000 1.000

06003491 6 Soybean, soy milk-babyfood or in 0.010000 1.000 1.000

06003500 6 Soybean, oil 0.010000 1.000 1.000

06003501 6 Soybean, oil-babyfood 0.010000 1.000 1.000

09023570 9B Squash, winter 0.010000 1.000 1.000

09023571 9B Squash, winter-babyfood 0.010000 1.000 1.000

15001200 15 Corn, field, flour 0.010000 1.000 1.000

15001201 15 Corn, field, flour-babyfood 0.010000 1.000 1.000

15001210 15 Corn, field, meal 0.010000 1.000 1.000

15001211 15 Corn, field, meal-babyfood 0.010000 1.000 1.000

15001220 15 Corn, field, bran 0.010000 1.000 1.000

15001230 15 Corn, field, starch 0.010000 1.000 1.000

15001231 15 Corn, field, starch-babyfood 0.010000 1.000 1.000

15001240 15 Corn, field, syrup 0.010000 1.000 1.000

15001241 15 Corn, field, syrup-babyfood 0.010000 1.000 1.000

15001250 15 Corn, field, oil 0.010000 1.000 1.000

15001251 15 Corn, field, oil-babyfood 0.010000 1.000 1.000

15001260 15 Corn, pop 0.010000 1.000 1.000

15001270 15 Corn, sweet 0.010000 1.000 1.000

15001271 15 Corn, sweet-babyfood 0.010000 1.000 1.000

15003440 15 Sorghum, grain 0.010000 1.000 1.000

Attachment 4: Chronic Output File

U.S. Environmental Protection Agency Ver. 2.00

DEEM-FCID Chronic analysis for DIMETHENAMIDE (1994-98 data)

Residue file name: E:\\working\\Dimetheneamid\\120051c.R98

Adjustment factor #2 NOT used.

Analysis Date 06-14-2006/15:19:20 Residue file dated:
06-14-2006/15:16:58/8

Reference dose (RfD, Chronic) = .05 mg/kg bw/day

===============================================================================

Total exposure by population subgroup

\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--

Total Exposure

\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--

Population mg/kg Percent of

Subgroup body wt/day Rfd

\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--
\-\-\-\-\-\-\-\-\-\-\-\-- \-\-\-\-\-\-\-\-\-\-\-\-\-\--

U.S. Population (total) 0.000205 0.4%

U.S. Population (spring season) 0.000204 0.4%

U.S. Population (summer season) 0.000218 0.4%

U.S. Population (autumn season) 0.000199 0.4%

U.S. Population (winter season) 0.000199 0.4%

Northeast region 0.000187 0.4%

Midwest region 0.000210 0.4%

Southern region 0.000197 0.4%

Western region 0.000230 0.5%

Hispanics 0.000233 0.5%

Non-hispanic whites 0.000200 0.4%

Non-hispanic blacks 0.000198 0.4%

Non-hisp/non-white/non-black 0.000242 0.5%

All infants (\< 1 year) 0.000605 1.2%

Nursing infants 0.000227 0.5%

Non-nursing infants 0.000749 1.5%

Children 1-6 yrs 0.000314 0.6%

Children 7-12 yrs 0.000210 0.4%

Females 13-19 (not preg or nursing) 0.000155 0.3%

Females 20+ (not preg or nursing) 0.000193 0.4%

Females 13-50 yrs 0.000194 0.4%

Females 13+ (preg/not nursing) 0.000194 0.4%

Females 13+ (nursing) 0.000265 0.5%

Males 13-19 yrs 0.000170 0.3%

Males 20+ yrs 0.000181 0.4%

Seniors 55+ 0.000188 0.4%

Children 1-2 yrs 0.000329 0.7%

Children 3-5 yrs 0.000316 0.6%

Children 6-12 yrs 0.000221 0.4%

Youth 13-19 yrs 0.000163 0.3%

Adults 20-49 yrs 0.000187 0.4%

Adults 50+ yrs 0.000189 0.4%

Females 13-49 yrs 0.000185 0.4%

\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--