Number range CHAPTER**[CURRICULUM VITAE]{.underline}**

[Name]{.underline}: Xin Wei Wang, Ph.D.

[Education]{.underline}:

> 1982 B.S., Shanghai Medical University, Shanghai, China
>
> 1984 M.S., Chinese Academy of Sciences, Shanghai, China

1991 Ph.D., New York University, New York, NY

[Brief Chronology of Employment and Training]{.underline}:

> 1982-1985 Graduate Research Assistant in Department of Pharmacology,
> Shanghai Institute of Materia Medica, Chinese Academy of Sciences,
> Shanghai, China
>
> 1985-1986 Research Fellow in Department of Pharmacology, The
> University of Texas, Health Science Center at Houston, Houston, TX
>
> 1986-1987 Research Scientist, Institute of Environmental Medicine, New
> York University Medical Center, New York, NY
>
> 1987-1991 Graduate Research Assistant in the Institute of
> Environmental Medicine, NYU Medical Center, New York, NY
>
> 1991 Postdoctoral Fellowship in Roche Institute of Molecular Biology,
> Nutley, NJ
>
> 1992-1995 CRTA Fellowship, Laboratory of Human Carcinogenesis,
> National Cancer Institute, National Institute of Health, Bethesda, MD
>
> 1995-1998 Senior Staff Fellow, Laboratory of Human Carcinogenesis,
> National Cancer Institute, National Institute of Health, Bethesda, MD
>
> 1998-2005 Investigator and Head, Liver Carcinogenesis Section,
> Laboratory of Human Carcinogenesis, National Cancer Institute,
> National Institute of Health, Bethesda, MD
>
> 2002-2005 Adjunct Associate Professor, Department of Pathology,
> University of Maryland Cancer Center, Baltimore, MD
>
> 2005-Pres. Adjunct Professor, Department of Pathology, University of
> Maryland Cancer Center, Baltimore, MD
>
> 2005-Pres. Senior Investigator and Head, Liver Carcinogenesis Section,
> Laboratory of Human Carcinogenesis, National Cancer Institute,
> National Institute of Health, Bethesda, MD

[Societies:]{.underline}

American Association for Cancer Research (member)

American Association for the Advancement of Science (member)

CAST-Biomedical/Pharmaceutical Society (board of director)

CCR-NCI HIV and Cancer Virology Faculty (members)

The International Society of Gastroenterological Carcinogenesis (Board
of Directors)

International Liver Cancer Association (Founding member)

[Faculty Membership]{.underline}:

CCR-NCI Cellular, Molecular and Developmental Biology Faculty

CCR-NCI Genetics, Genomics, and Proteomics Faculty

CCR-NCI Gene Expression Faculty

CCR-NCI Bioinformatics, Biostatistics and Computational Biology Faculty

CCR-NCI Molecular Targets Faculty

Gastrointestinal Malignancies Working Group

Metastasis Working Group

[Honors, Distinguished Lectures and Other Special Scientific
Recognition:]{.underline}

> Recipient of Best student awards from Shanghai First Medical College,
> 1980-1981
>
> Graduate fellowship award from Chinese Academy of Sciences, 1982-1985
>
> Recipient of Best thesis (MS) award from Committee of Pharmaceutics
> Sinica, Shanghai Branch, 1984
>
> Member of Graduate Student Council in Shanghai Institute of Materia
> Medica, Chinese Academy of Sciences, 1983-1984
>
> Graduate research assistantship from New York University Medical
> Center, 1987-1991
>
> Recipient of a student travel award from American Society of
> Toxicology for attending annual meeting in 1988
>
> Recipient of Graduate student award for meritorious research presented
> by the Carcinogenicity Specialty Section, Society of Toxicology, 1991
>
> Invited lecture, NCI, NIH, Bethesda, MD, 1992
>
> Invited speaker to the Life Sciences Symposium on Human Genetics,
> Association for Chinese Scientists in America, the Great Washington
> Chapter, 1993
>
> Invited lecture, INSERM Unit, University of Strasbourg, Strasbourg,
> France, 1994
>
> Invited lecture, Department of Cell Biology and Genetics, Medical
> Genetics Center, Erasmus University, Rotterdam, Netherlands, 1994
>
> Invited speaker, Symposium on DNA Repair and Human Syndrome, NIH
> Research Festivals, 1994
>
> Invited speaker, DNA repair interest group, NIH, Bethesda, MD, 1995
>
> Invited speaker, Genetic Susceptibility and Molecular Carcinogenesis,
> AACR, Keystone, 1996
>
> Invited speaker, 1996 Shanghai International Symposium on Liver Cancer
> & Hepatitis, Shanghai, China, 1996
>
> Invited lecture, Department of Pathology & Oncology, University of
> Maryland Cancer Center, Baltimore, MD, 1996
>
> Invited speaker, IASLC Workshop, Nancy, France, 1996
>
> Invited speaker, symposium on apoptosis, Scanning Microscopy
> International, Chicago, IL, 1997
>
> Invited speaker, Cancer genetics and tumor suppressor genes
> conference, Frederick, MD, 1997
>
> Invited lecture, National Cancer Institute, Bethesda, MD, 1997
>
> Invited speaker, XVIII International Congress of Genetics, Beijing,
> China, 1998
>
> Invited speaker, the 5^th^ International Symposium on Dendritic Cells
> in Fundamental Clinical Immunology, Pittsburgh, PA, 1998
>
> Invited lecture, The National Capital Area Branch of the Society for
> In Vitro Biology, Beltsville, MD, 1998
>
> Recipient of NIH Technology Transfer Awards, 1998, 2000, 2002-2007
>
> Invited speaker, the 14^th^ Aspen Cancer Conference, Aspen, CO, 1999
>
> Invited speaker, Symposium on DNA Repair and Apoptosis, NIH Research
> Festivals, 1999
>
> Invited lecture, Department of Biochemistry and Molecular Biology,
> University of Maryland, Baltimore, MD, 2000
>
> Invited lecture, Department of Pathology, Virginia Commonwealth
> University, Richmond, VA, 2000
>
> Invited speaker, the 9^th^ International Congress of Toxicology,
> Brisbane, Australia, 2001
>
> Invited speaker, the 16^th^ Aspen Cancer Conference, Aspen, CO, 2001
>
> Invited lecture, Multicenter Hemophilia Cohort Study-II, Washington,
> DC, 2002
>
> Invited speaker, Molecular Genomics 2002: profiling of gene
> expression, Galveston, TX, 2002
>
> Lecture, Graduate Class for Topics in Molecular Epidemiology, Lombardi
> Cancer Center, Georgetown University Medical Center, Washington, DC,
> 2002
>
> Lecture, Clinical Center, NIH, Bethesda, MD, 2002
>
> Invited speaker, FASEB Summer Research Conference on "Mechanisms of
> Liver Growth, Differentiation and Molecular Pathogenesis of Hepatic
> Diseases, Snow Mass, CO, 2002
>
> Organizer, International Workshop on Human Hepatocellular Carcinoma,
> Bethesda, MD, 2002
>
> Invited lecture, Liver Cancer Institute and Zhongshan Hospital, Fudan
> University, Shanghai, China, 2002
>
> Invited lecture, Cancer Institute/Hospital, Chinese Academy of Medical
> Sciences, Beijing, China 2002
>
> Invited lecture, Thomas Jefferson University, Jefferson Center for
> Biomedical Research, Doylestown, PA, 2002
>
> Invited lecture, Bernie Carter Center for Immunology Research,
> University of Virginia Health Sciences Center, Charlottesville, VA,
> March 2003
>
> Invited lecture, Graduate Class for Topics in Molecular Epidemiology,
> Lombardi Cancer Center, Georgetown University Medical Center,
> Washington, DC, May 2003
>
> Invited lecture, The Thirteenth International Symposium of Hiroshima
> Cancer Seminar, Hiroshima, Japan, October 2003
>
> Invited lecture, Symposium on Molecular Diagnosis of Human Cancer,
> Sponsored by Shanghai Medical Association, Shanghai, China, November
> 2003
>
> Invited lecture, The GW Cancer Institute, The George Washington
> University Medical Center, Washington, DC, January 2004
>
> Invited lecture, Hong Kong Shanghai International Liver Congress 2004,
> Hong Kong, China, February 2004
>
> Invited lecture, The 19th Aspen Cancer Conference, Aspen, Colorado,
> August 2004
>
> Invited lecture, The 3rd International Conference on
> Gastroenterological Carcinogenesis, Sapporo, Japan, August 2004
>
> Invited lecture, The 35th Environmental Mutagen Society Annual
> Meeting, Pittsburgh, Pennsylvania, October 2004
>
> Guest speaker, Division of Gastroenterology and Liver Diseases, Mount
> Sinai School of Medicine; New York, New York, October 2004
>
> Keystone Symposia Program Committee Meeting (as an ad hoc member),
> Keystone, Colorado, January 2005
>
> Distinguished lecturer, Frontiers in Oncology Seminar Series:
> "Progress on molecular diagnosis and molecular targets for human
> hepatocellular carcinoma". University of Maryland Greenebaum Cancer
> Center, Baltimore, MD, March 2005
>
> Invited speaker, The National Cancer Institute Liver Cancer Symposium,
> Bethesda, MD, April 2005
>
> Invited speaker, The 96th Annual Meeting of the American Association
> for Cancer Research, Anaheim, CA, April 2005
>
> Invited speaker and co-organizer, NCI Symposium, Shanghai-Hong Kong
> International Liver Congress 2006, Shanghai, China, March 2006
>
> Invited speaker, CNIO Cancer Conference, Madrid, Spain, May 2006
>
> Invited speaker, 4th International Society of Gastroenterological
> Carcinogenesis Conference, Hawaii, August 2006
>
> Invited speaker, GTCbio 5th annual conference on Cytokines and
> Inflammation, Breckenridge, CO, January 2007
>
> Invited speaker, The 96th Annual Meeting of the American Association
> for Cancer Research, Los Angeles, CA, April 2007
>
> Invited speaker, Center for Human Genomics Seminar Series, Wake Forest
> University School of Medicine, May, 2007
>
> Invited speaker, Cancer Genetics and Epidemiology Program Monthly
> Seminar Series, the Lombardi Cancer Center at Georgetown University,
> Washington, DC, June 2007

[Administrative Service]{.underline}:

[Institutional Service]{.underline}

NCI-UMD Tissue Resource Technical Review Panel, 2000, 2005

> NIH FARE Committee, 2001-2002, 2004-2005

LHC Microarray Interest Group, 2002-2004

NIH-NCI HCC Clinical Steering Committee, 2005-Pres.

CCR-NCI Inflammation and Cancer Initiative Discussion, 2005

[National Service]{.underline}

> Organizer, International Workshop on Human Hepatocellular Carcinoma,
> Bethesda, Maryland, 2002
>
> The International Society of Gastroenterological Carcinogenesis (Board
> of Directors), 2003-2005
>
> NRC Research Advisor, 2005-Pres.
>
> Co-organizer, NCI- cosponsored Symposium on liver cancer at the
> Shanghai-Hong Kong Liver Congress, March 2006
>
> Co-organizer, Keystone Symposia, Beijing, China, 2007
>
> Peer Review Committee Member, American Cancer Society, 2007-Pres.

[Reviewer for the following Scientific Journals]{.underline}:
(1995-Present)

American Journal of Pathology

Biochimica et Biophysica Acta

> Cancer

Cancer Detection and Prevention

> Cancer Epidemiology, Biomarkers & Prevention

Cancer Genetics and Cytogenetics

Cancer Letters

> Cancer Research

Carcinogenesis (**Editorial Board**), 2002-2005

Clinical Cancer Research

> Gastroenterology
>
> Genes and Development
>
> Experimental Cell Research

FEBS Letters

Hepatology

Immunity

Journal of Biological Chemistry

Journal of Clinical Investigation

Journal of Hepatology

Journal of National Cancer Institute

Molecular and Cellular Biology

Molecular Cancer Research

> Molecular Carcinogenesis

Neoplasia

New England Journal of Medicine

Oncogene

Proc. Natl. Acad. Sci. USA

Photochemistry & Photobiology

[Teaching Service]{.underline}:

Preceptor, HHMI-NIH Research Scholars Program (6 students)

> 1994-1995 Heidi Yeh, M.D., University of Pennsylvania
>
> 1995-1996 Michael Gibson, M.D., University of Maryland
>
> 1996-1997 Nissim Khabie, M.D., Mayo clinics
>
> 1997-1998 Anne Manicone, M.D., University of Washington
>
> 2003-2004 Brian Zipser, M.D., Brown University
>
> 2006- Giang Nguyen, Albany Medical College

2000 Preceptor, BESIP of Whitaker Foundation of NIH

2000 Preceptor, UC Irvine Washington DC Center Program

1998-Pres. Preceptor, NCI pre-CRTA program

1999-Pres. Preceptor, NCI Summer Research Internship (7 students)

> 2000-2004 Guest Lecturer, the Topics in Molecular Epidemiology course
> Georgetown University Medical School

[Thesis Advisor]{.underline}:

1996 Jill D. Coursen, M.S., Hood College

2002 Qinghai Ye, M.D./Ph.D., Shanghai Medical University

2006 Huliang Jia, M.D./Ph.D., Fudan University

2007 Quiling Lin, M.D./Ph.D., Fudan University

[Thesis Committee]{.underline}:

> 1999 Joo-Yeon Yoo, Ph.D., University of Maryland

[Grant Support]{.underline}:

1998-2000 Principal Investigator, Mechanism of Human liver
carcinogenesis, DBS Budget Allocation, NCI, NIH

2000-Pres. Principal Investigator, Mechanism of Human liver
carcinogenesis, CCR Budget Allocation, NCI, NIH

[Additional Competitive Funds]{.underline}:

> 2001 Principal Investigator
>
> SAGE transcript profiles. DBS, NCI, NIH;
>
> Total direct costs awarded: \$40,000
>
> 2001 Principal Investigator
>
> Molecular profiling of metastatic hepatocellular carcinoma. DBS, NCI
>
> Total direct costs awarded: \$19,500
>
> 2001 Principal Investigator Program travel. DBS, NCI, NIH
>
> Total direct costs awarded: \$15,000
>
> 2002 Principal Investigator
>
> International Workshop. CCR, NCI, NIH,
>
> Total direct costs awarded: \$25,000
>
> 2002 Principal Investigator
>
> International Workshop. NIH Office of Rare Diseases
>
> Total direct costs awarded: \$20,000
>
> 2003 Principal Investigator
>
> Program travel. CCR, NCI, NIH
>
> Total direct costs awarded: \$15,000
>
> 2004 Principal Investigator
>
> Program travel. CCR, NCI, NIH
>
> Total direct costs awarded: \$15,000
>
> 2005 Principal Investigator
>
> Gene expression profiling of HCC by microarray
>
> Total direct costs awarded: \$60,000
>
> 2005 Principal Investigator MicroRNA expression profiling of HCC
>
> Total director costs awarded: \$90,000
>
> 2006 Principal Investigator
>
> Program travel. CCR, NCI, NIH
>
> Total direct costs awarded: \$15,000
>
> 2005 Principal Investigator
>
> Affymetrix HTA analysis of HCC
>
> Total director costs awarded: \$50,000 (ODRS support)
>
> 2007 Principal Investigator
>
> Program travel. CCR, NCI, NIH
>
> Total direct costs awarded: \$15,000
>
> 2007 Principal Investigator
>
> Acquisition of ABI 7900HT Fast Real-Time PCR System
>
> Total direct costs awarded: \$90,000

[Grant Reviewer:]{.underline}

> 1998-2000 Cancer Research Campaign
>
> 2003-Pres. Cancer Research UK
>
> 2001 Jeffress Memorial Trust
>
> 2003-Pres. Italian Association for Cancer Research
>
> 2004-Pres. Research Grants Council of Hong Kong
>
> 2006 NIAID, NIH, PO1 grant review
>
> 2007-Pres. ACS Study Section on Cancer Genetics

[Graduate Student Thesis Committee:]{.underline}

1996 Jill D. Coursen, M.S., Biomedical Science, Hood College

1999 Joo-Yeon Yoo, Ph.D., Biomedical Science, UMBC

2002 Qinghai Ye, M.D./Ph.D., Clinical Oncology, Shanghai Medical
University

2006 Huliang Jia, M.D./Ph.D., Fudan University

> Libin Xu, M.D./Ph.D. candidate, Molecular Immunology Branch, National
> Laboratory of Molecular Oncology, Cancer Institute/Hospital, Chinese
> Academy of Medical Sciences

[Current Lab members]{.underline}:

> 1998-Pres. Marshonna Forgues, B.A., Lab technician
>
> 2002-Pres. Anuradha Budhu, Ph.D., Staff Scientist
>
> 2005-Pres. Taro Yamashita, M.D., Ph.D., Postdoctoral fellow
>
> 2006-Pres. Zhipeng Yu, B.A., Lab technician
>
> 2006-Pres. Junfang Ji, M.D., Ph.D., Postdoctoral fellow
>
> 2006-Pres. Stephanie Roessler, Ph.D., Postdoctoral fellow
>
> 2007-Pres. Lei Zhao, M.D., Ph.D., Visiting fellow
>
> 2007-Pres. Guoling Lin, M.D., Visiting fellow

[Former Lab members]{.underline}:

> 1992-1994 Hieu Le, NCI staying school student program
>
> 1994-1996 Lorraine Le, NCI staying school student program
>
> 1994-1995 Shawn Tang, NCI staying school student program
>
> 1997-1998 Jill D. Coursen, M.S., Lab technician
>
> 1998-1999 Ann Tseng, M.D., NIH pre-IRTA program; currently: Oregon
> Health & Science University
>
> 1998-2001 Chuan-Ging Wu, M.D., Ph.D., NCI CRTA program; currently:
> Food and Drug Administration
>
> 1999 Haress Rahim, D.D.S., NCI summer student scholar program
>
> 1999, 2000 Lily Wong, NCI summer student scholar program
>
> 2000 Michele Abbasi, NCI summer student scholar program
>
> 2000-2001 Teh-Ia Huo, M.D., Postdoc; currently: Yang Ming University
>
> 2000 David M. Salvay, M.S., BESIP of Whitaker Foundation of NIH;
> currently: Northwestern University
>
> 2000 Michele Abbasi, UC Irvine Washington DC center program
>
> 2001-2004 Jin Woo Kim, Ph.D., NCI CRTA program; currently: Wake Forest
> University School of Medicine
>
> 2001-2002 Jessica Simes, Ph.D., NCI pre-CRTA program; currently:
> Northwestern University Medical School
>
> 2000, 20001 Alice Uy, NCI summer student scholar program
>
> 2000, 2001 Shabina Siddique, M.D., NCI summer student scholar program;
> currently: Johns Hopkins University
>
> 2002 Qinghai Ye, M.D., Ph.D., Graduate student; currently: Liver
> Cancer Institute, Shanghai, China
>
> 2002 Lavanya Viswanathan, NCI summer student scholar program
>
> 2003-2005 Wei Wang, Ph.D., NCI Visiting Fellow; currently: Food and
> Drug Administration
>
> 2004-2006 Vivian Takafuji, Ph.D., NCI CRTA program
>
> 2005-2006 Mi Jung Lim, Ph.D., NCI Visiting Fellow; currently: Biology
> Laboratory, South Korea
>
> 2005 Nicholas Younes, NCI summer student scholar program
>
> 2005-2006 Huliang Jia, M.D., Ph.D., Graduate student; currently: Liver
> Cancer Institute, Shanghai, China
>
> 2006 Mindy Wei, NCI summer student scholar program
>
> 2006 Andy Chen, NCI summer student scholar program
>
> 2006, 2007 Bhumi Patel, NCI summer student scholar program
>
> 2007 Louie Zhou, NCI summer student scholar program

[Research Interests]{.underline}:

> 1\. Roles of oncogenes and tumor suppressor genes in regulation of
> genomic stability, including multiple cell cycle checkpoint controls,
> DNA repair and programmed cell death (apoptosis).

2\. Mechanisms of liver cancer genetics.

[Inventions and Patents Assigned to U.S. Government:]{.underline}

> 1\. U.S. Patent No. 5,985,829. Patent Serial No. 08/675,631, filed
> 6/30/1996 entitled "Screening assays for compounds that cause
> apoptosis and related compounds" by Xin Wei Wang, Curtis Harris and
> Jan Hoeijmakers.
>
> 2\. U.S. Patent No. 6,613,318. Patent Serial No. 60/126,069,
> E-232-98/0, filed 3/25/1999 entitled "Methods for identifying
> modulators of Gadd45 polypeptide activity, and inhibitors of such
> activity" by Xin Wei Wang, Curtis Harris, Jill Coursen, Albert
> Fornace, Qimin Zhan.
>
> 3\. U.S. PHS Employee Invention. The Establishment of
> telomerase-immortalized human liver epithelial cell lines.

4.  U.S. PHS Employee Invention (2002). Methods of diagnosing potential
    for developing hepatocellular carcinoma or metastasis and of
    identifying therapeutic targets.

5.  U.S. Patent application (2005). Compositions and Methods for
    Diagnosis and Treatment of Metastatic Disease.

6.  U.S. Patent application (2005). Method of Screening for
    hepatocellular carcinoma.

7.  U.S. PHS Employee Invention (2006). A novel diagnostic and
    therapeutic strategy for metastatic hepatocellular carcinoma by
    targeting a unique region of osteopontin.

8.  U.S. Patent application (2006). Methods of determining the prognosis
    of an adenocarcinoma.

9.  U.S. PHS Employee Invention (2006). A unique microRNA expression
    signature predicts survival, metastases and recurrence in
    hepatocellular carcinoma.

10. U.S. Patent No. 7,125,850B2. Patent Serial No. 11/297,160, filed
    12/7/2005 entitled "Methods for Identifying Inhibitors of GADD45
    Polypeptide Activity and Inhibitors of Such Activity".

11. International Patent Application No. PCT/US06/42591 (2006). Claims
    Priority U.S. Provisional Patent Application No. 60/732,332 filed
    11/1/2005 entitled "Method of Screening for Hepatocellular
    Carcinoma".

12. Provisional Patent application, 60/942,833 (2007). Methods for
    determining hepatocellular carcinoma subtype and detecting hepatic
    cancer stem cells.

[Laboratory Address:]{.underline} Laboratory of Human Carcinogenesis

NIH, NCI, CCR

Building 37, Room 3044A

Bethesda, MD 20892-4258

Tel: (301) 496-2099

Fax: (301) 496-0497

Email: xw3u@nih.gov

**BIBLIOGRAPHY**

[Articles in Journals]{.underline}

1.  Huang, C. C., Han, J. X., Yue, X. F., Shen, Z. M., Wang, X. W.,
    Wu, F. G. and Xu, B.: Cytotoxicity and sister chromatid exchanges
    induced *in vitro* by six anticancer drugs developed in the
    People\'s Republic of China. [Journal of National Cancer
    Institute]{.underline} 71: 841-847, 1983.

2.  Wang, X. W., Yue, X. F., Han, J. X., Wu, F. G., Shen, Z. M., Xu, B.
    and Huang, C. C.: Studies on cytotoxicity and induction of sister
    chromatid exchanges in V79 cells with three antitumor agents. [KEXUE
    TONGBAO]{.underline} 29: 1268-1271, 1984.

3.  Wang, X. W., Shen, Z. M., Yang, J. L. and Xu, B.: Inhibitory effect
    of hydroxy-camptothecin on colony formation of KB cells and DNA
    damage. [Acta of Pharmaceutics Sinica]{.underline} 21: 492-497,
    1986.

    4\. Sugiyama, M., Wang, X. W. and Costa, M.: Comparison of DNA
    lesions and cytotoxicity induced by calcium chromate in human, mouse
    and hamster cell lines. [Cancer Res.]{.underline} 46: 4547-4551,
    1986.

    5\. Wang, X. W., Yu, W. J., Shen, Z. M., Yang, J. L. and Xu, B.:
    Cytotoxicity of hydroxycamptothecin and four other antineoplastic
    agents on KB cells. [Acta of Pharmacology Sinica]{.underline} 8:
    86-90, 1987.

    6\. Conway, K., Wang, X. W., Xu, L. and Costa, M.: Effect of
    magnesium on nickel-induced genotoxicity and cell transformation.
    [Carcinogenesis]{.underline} 8: 1115-1121, 1987

    7\. Zelikoff, J. T., Li, J. H., Hartwig, A., Wang, X. W., Costa, M.
    and Rossman, T. G.: Genetic toxicology of lead compounds.
    [Carcinogenesis]{.underline} 9: 1727-1732, 1988.

    8 Wang, X. W., Imbra, R. J. and Costa, M.: Characterization of mouse
    cell lines resistant to nickel (II) ions. [Cancer Res.]{.underline}
    48: 6850-6854, 1988.

    9\. Imbra, R. J., Wang, X. W. and Costa, M.: Characterization of a
    nickel resistant mouse cell line. [Biological Trace Element
    Research]{.underline} 21: 97-103, 1989.

    10\. Wang, X. W. and Costa, M.: Alteration of nickel binding
    proteins in nickel resistant cell. [Cancer Comm.]{.underline} 1:
    351-358, 1989.

    11\. Klein, C. B., Conway, K., Wang, X. W., Bhamra, R. F., Lin, X.
    H., Cohen, M. D., Lois, A., Barrett, J. C. and Costa, M.: Senescence
    of nickel-transformed cells by a mammalian X chromosome: possible
    epigenetic control. [Science]{.underline} 251: 796-799, 1991.

    12\. Wang, X. W. and Costa, M.: Changes in protein phosphorylation
    in wild type and nickel-resistant cells and their involvement in
    morphological elongation. [Biol. Metal]{.underline} 4: 201-206,
    1991.

    13\. Wang, X. W., Lin, X. H., Klein, C. B., Bhamra, R. F.,
    Lee, Y. W. and Costa, M.: A conserved region in human and Chinese
    hamster X chromosomes can induce cellular senescence of
    nickel-transformed Chinese hamster cell lines.
    [Carcinogenesis]{.underline} 13: 555-561, 1992.

    14\. Wang, X. W., Forrester, K., Yeh, H., Feitelson, M. A., Gu, J-R.
    and Harris, C. C.: Hepatitis B virus X protein inhibits p53
    sequence-specific DNA binding, transcriptional activity, and
    association with transcription factor ERCC3. [Proc. Natl. Acad. Sci.
    USA]{.underline} 91: 2230-2234, 1994.

    15\. Wang, X. W., Yeh, H., Schaeffer, L., Roy, R., Moncollin, V.,
    Egly, J.-M., Wang, Z., Friedberg, E. C., Evans, M. K., Taffe, B. G.,
    Bohr, V. A., Weeda, G., Hoeijmakers, J. H. J., Forrester, K. and
    Harris, C. C.: p53 modulation of TFIIH associated nucleotide
    excision repair activity. [Nature Genetics]{.underline} 10: 188-195,
    1995.

    16\. Forrester, K., Lupold, S. E., Ott, V. L., Chay, C. H.,
    Wang, X. W. and Harris, C. C.: Effects of p53 mutants on wild-type
    p53-mediated transactivation are cell type dependent.
    [Oncogene]{.underline} 10: 2103-2111, 1995.

    17\. Wang, X. W., Gibson, M., Vermulen, W., Yeh, H., Forrester, K.,
    Sturzbacher, H.-W., Hoeijmakers, J. H. J. and Harris, C. C.:
    Abrogation of p53-induced apoptosis by the hepatitis B viral X gene.
    [Cancer Res.]{.underline} 55: 6012-6016, 1995.

    18\. Forrester, K., Ambs, S., Lupold, S. E., Kapust, R. B.,
    Spillare, E. A., Weinberg, W.C., Felley-Bosco, E., Wang, X. W.,
    Geller, D. A., Billiar, T. R. and Harris, C. C.: Nitric
    oxide-induced p53 accumulation and regulation of inducible nitric
    oxide synthase (NOS2) expression by wild-type p53. [Proc. Natl.
    Acad. Sci. USA]{.underline} 93: 2442-2447, 1996.

    19\. Wang, X. W., Vermulen, W., Coursen, J. D., Gibson, M. J.,
    Lupold, S. E., Forrester, K., Xu, G., Elmore, L., Yeh, H.,
    Hoeijmakers, J. H. J. and Harris, C. C.: The XPB and XPD DNA
    helicases are components of the p53-mediated apoptosis pathway.
    [Genes & Development]{.underline} 10: 1219-1232, 1996.

    20\. Xu, G. W., Sun, Z. T., Forrester, K., Wang, X. W.,
    Coursen, J. D. and Harris, C.C.: Tissue-specific growth suppression
    and chemosensitivity promotion in human hepatocellular carcinoma
    cells by retroviral-mediated transfer of the wild-type p53 gene.
    [Hepatology]{.underline} 24: 1264-1268, 1996.

    21\. Wang, X. W. and Harris, C. C.: TP53 tumor suppressor gene:
    clues to molecular carcinogenesis and cancer therapy. [Cancer
    Surveys]{.underline} 28: 169-196, 1996.

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22. Adler, V., Pincus, M. R., Minamoto, T., Fuchs, S. Y., Bluth, M. J.,
    Brandt-Rauf, R.W., Friedman, F. K., Robinson, R. C., Chen, J. M.,
    Wang, X. W. Harris, C. C. and Ronai, Z.: Conformation-dependent
    phosphorylation of p53. [Proc. Natl. Acad. Sci. USA]{.underline} 94:
    1686-1691, 1997.

23. Buchhop, S., Gibson, M. K., Wang, X. W., Wagner, P., Sturzbecher,
    H.-W. and Harris, C. C.: Interaction of p53 with the human Rad51
    protein. [Nucleic Acid Res]{.underline}. 25: 3868-3874, 1997.

24. Wang, X. W. and Harris, C. C.: p53 mofulation of cell cycle and
    apoptosis. [Scanning Microscopy]{.underline} 11: 953-965, 1997.

25. Wang, X. W. and Harris, C. C.: p53 tumor-suppressor gene: clues to
    molecular carcinogenesis. [J. Cell. Physiol.]{.underline} 173:
    247-255, 1997.

26. Elmore, L. W., Hancock, A. R., Chang, S.-F., Wang, X. W., Chang, S.,
    Callahan, C. P., Geller, D. A., Will, H. and Harris, C. C.:
    Hepatitis B virus X protein and p53 tumor suppressor interactions in
    the modulation of apoptosis. [Proc. Natl. Acad. Sci.
    USA]{.underline} 94: 14707-14712, 1997.

27. Parekh, T. V., Wang, X. W., Makri-Werzen, D. M., Greenspan, D. S.
    and Newman, M. J.: Type V collagen is an epithelial cell cycle
    inhibitor that is induced by and mimics the inhibitory effects of
    TGF-β1. [Cell Growth & Differ.]{.underline} 9: 423-433, 1998.

28. Jia, L., Wang, X. W. and Harris, C. C.: Hepatitis B virus X protein
    inhibits nucleotide excision repair. [Int. J. Cancer.]{.underline}
    80: 875-879, 1999.

29. Zhan, Q., Antinore, M. J., Wang, X. W., Carrier, F., Smith, M. L.,
    Harris, C. C. and Fornace, A. J. Jr: Association with Cdc2 and
    inhibition of Cdc2/cyclin B1 kinase activity by the p53-regulated
    protein Gadd45. [Oncogene]{.underline}. 18: 2892-2900, 1999.

30. Zhou, X., Wang, X. W., Xu, L., Hagiwara, K., Nagashima, M. and
    Harris, C. C.: C-terminal domain (CTD) of p53 is involved in
    p53-mediated apoptosis and transcriptional transactivation. [Cancer
    Res]{.underline}. 59: 843-848, 1999.

31. Xu, X., Weaver, Z., Linke, S. P., Li, C., Gotay, J., Wang, X. W.,
    Harris, C. C., Ried, T. and Deng, C. X.: Centrosome amplification
    and a defective G2/M checkpoint induce genetic instability in BRCA1
    exon 11 isoform-deficient mice. [Mol. Cell]{.underline} 3: 389-395,
    1999.

32. Wang, X. W., Coursen, J. D., Zhan, Q., Fornace, A. J., Jr and
    Harris, C. C.: GADD45 induction of a G2-M cell cycle checkpoint.
    [Proc. Natl. Acad. Sci. USA]{.underline} 96: 3706-3711, 1999.

33. Robles, A. I., Wang, X. W. and Harris, C. C.: Drug-induced apoptosis
    is delayed and reduced in XPD lymphoblastoid cell lines: possible
    role of p53 interaction with TFIIH in the induction of apoptosis.
    [Oncogene]{.underline} 18: 4681-4688, 1999.

34. Spillare, E. A., Robles, A. I., Wang, X. W., Shen, J-C., Yu, C-E.,
    Schellenberg, G. D. and Harris, C.C.: p53-mediated apoptosis is
    attenuated in Werner Syndrome Cells. [Genes &
    Development]{.underline} 13: 1355-1360, 1999.

35. Mazur, S. J., Sakaguchi, K., Appella, E., Wang, X. W., Harris, C. C.
    and Bohr, V. A.: Preferential binding of tumor suppressor p53 to
    positively or negatively supercoiled DNA involves the C-terminal
    domain. [J. Mol. Biol.]{.underline} 292: 241-249, 1999.

36. Wang, X. W.: Role of p53 and apoptosis in carcinogenesis.
    [Anticancer Res]{.underline}. 19: 4759-4771, 1999.

37. Yoo, J. Y., Wang, X. W., Rishi, A. K., Lessor, T., Xia, X. M.,
    Gustafson, T. A. and Hamburger, A. W.: Interaction of the PA2G4
    (EBP1) protein with ErbB-3 and regulation of this binding by
    heregulin. [Br. J. Cancer]{.underline} 82: 683-690, 2000.

38. Yang, Q., Manicone, A., Coursen, J. D., Linke, S. P., Nagashima, M.,
    Forgues, M., and Wang, X. W.: Involvement of a unique acidic motif
    (DEDDDR) in a GADD45-medicated G2/M Checkpoint. [J. Biol.
    Chem]{.underline}. 275: 36892-36898, 2000.

39. Liu, J., Akoulitchev, S., Weber, A., Ge, H., Chuikov, S., Libutti,
    D., Wang, X. W., Conaway, J. W., Harris, C. C., Conaway, R. C.,
    Reinberg, D. and Levens, D.: Defective interplay of activators and
    repressors with TFIIH in Xeroderma Pigmentosum. [Cell]{.underline}
    104: 353-363, 2001.

40. Huo, T-I, Wang, X. W., Forgues, M., Wu, C-G, Spillare, E. A.,
    Giannini, C., Brechot, C. and Harris, C. C.: Hepatitis B virus X
    mutants derived from human hepatocellular carcinoma retain the
    ability to abrogate p53-induced apoptosis. [Oncogene]{.underline}
    20: 3620-3628, 2001.

41. Brosh, R. M., Jr., Karmakar, P., Sommers, J. A., Yang, Q., Wang, X.
    W., Spillare, E. A., Harris, C. C. and Bohr, V. A.: p53 modulates
    the exonuclease activity of Werner syndrome protein. [J. Biol
    Chem]{.underline}. 276: 35093-35102, 2001.

42. Wang, X. W., Tseng, A., Ellis, N. A., Spillare, E. A., Linke, S. P.,
    Robles, A.I., Seker, H., Yang, Q., Hu, P., Beresten, S., Bemmels,
    N.A., Garfield, S. and Harris, C. C.: Functional interaction of p53
    and BLM DNA helicase in apoptosis. [J. Biol Chem]{.underline}. 276:
    32948-32955, 2001.

43. Nagashima, M., Shiseki, M., Miura, K., Hagiwara, K., Linke, S. P.,
    Pedeux, R., Wang, X. W., Yokota, J., Riabowol, K. and Harris, C. C.:
    DNA damage-inducible gene p33ING2 negatively regulates cell
    proliferation through acetylation of p53. [Proc. Natl. Acad. Sci.
    USA]{.underline}, 98: 9671-9676, 2001.

44. Wu, C. G., Salvay, D. M., Forgues, M., Valerie, K., Farnsworth, J.,
    Markin, R. S. and Wang, X. W.: Distinctive gene expression profiles
    associated with hepatitis B virus X protein. [Oncogene]{.underline}
    20: 3674-3682, 2001.

45. Forgues, M., Marrogi, A. J., Wu, C., Spillare, E., Yang, Q.,
    Yoshida, M., Wang, X. W.:

    Involvement of Crm1-mediated nuclear export in hepatitis B virus
    Hbx-mediated

transactivation. [J. of Biol. Chem.]{.underline} 276: 22797-22803, 2001.

46\. Wang, X.W. Microinjection technique used to study functional
interaction between p53 and hepatitis B virus X gene in apoptosis. [Mol.
Biotechnol]{.underline}. 18: 169-177, 2001.

47\. Wang, X. W., Hussain, S. P., Huo, T. I, Wu, C. G., Forgues, M.,
Hofseth, L. J., Brechot, C., Harris, C. C.: Molecular pathogenesis of
human hepatocellular carcinoma. [Toxicology]{.underline} 181-182: 43-47,
2002.

48\. Yang, Q., Zhang, R., Wang, X. W., Spillare, E. A., Linke, S. P.,
Subramanian, D., Griffith, J. D., Li, J. L., Hickson, I. D., Shen, J.
C., Loeb, L. A., Mazur, S. J., Appella, E., Brosh Jr., R. M., Karmakar,
P., Bohr, V. A. and Harris, C.C.: The Proceeding of Holliday Junctions
by BLM and WRN Helicases is Regulated by p53. [J. of Biological
Chemistry]{.underline} 277: 31980-31987, 2002.

49\. Wu, C. G., Forgues, M., Siddique, S., Farnsworth, J., Kristoffer,
V. Wang, X. W.: SAGE transcript profiles of normal primary human
hepatocytes expressing oncogenic hepatitis B virus X protein. [FASEB
Journal]{.underline} 12: 1665-1667, 2002.

50\. Staib, F., Hussain, S. P., Hofseth, L. J., Wang, X. W. and Harris
C. C.: TP53 and Liver Carcinogenesis. [Human Mutation]{.underline} 21:
201-216, 2003.

51\. Kim, J. W. and Wang, X. W.: Gene expression profiling of
preneoplastic liver disease and liver cancer: a new era for improved
early detection and treatment of these deadly diseases?
[Carcinogenesis]{.underline} 24: 363-369, 2003.Number range CHAPTER

52\. Forgues, M., Difilippantonio, M. J., Linke, S. P., Ried, T.,
Nagashima, K., Feden, J., Valerie, K., Fukasawa, K. and Wang, X. W.: 
Involvement of Crm1 in HBx-induced unscheduled centriole splitting and
abnormal mitotic spindles. [Mol. Cell Biol]{.underline}. 23: 5282-5292,
2003.

53\. Linke, S. P., Sengupta, S., Khabie, N., Jeffries, B. A., Buchhop,
S., Miska, S., Henning, W.,

Pedeux, R., Wang, X. W., Hofseth, L. J., Yang, Q., Garfield, S. H.,
Sturzbecher, H. W. and

Harris, C. C.: p53 interacts with hRAD51 and hRAD54, and directly
modulates homologous recombination. [Cancer Research]{.underline} 63:
2596-2605, 2003.

54\. Ye, Q. H., Qin, L. X., Forgues, M., He, P, Kim, J. W., Peng, A. C.,
Simon, R., Li, Y., Robles, A. I., Chen, Y., Ma, Z. C, Wu, Z. Q, Ye, S.
L., Liu, Y. K., Tang, Z. Y. and Wang,

X. W.: Predicting Hepatitis B Virus-Positive Metastatic Hepatocellular
Carcinomas Using Gene

Expression Profiling and Supervised Machine Learning. [Nature
Medicine]{.underline} 9: 416-423, 2003.

55\. Ashktorab, H., Ahmed, A., Littleton, G., Wang, X. W., Allen, C. R.,
Tackey, R., Walters, C. and Smoot, D. T.: p53 and p14 increase
sensitivity of gastric cells to H. pylori-induced apoptosis. [Dig Dis
Sci.]{.underline} 48: 1284-1291, 2003.

56\. Kim, J. W., Ye, Q. H., Forgues, M., Chen, Y., Budhu, A., Sime, J.,
Hofseth, L. J., Kaul, R. and Wang, X. W.: Cancer-associated molecular
signatures in the cirrhotic tissue samples of patients with chronic
liver disease. [Hepatology]{.underline} 39: 1-10, 2004.

57\. Hofseth, L. J., Robles, A. I., Yang, Q., Wang, X. W., Hussain, S.
P. and Harris, C. C.: p53: At the crossroads of molecular carcinogenesis
and molecular epidemiology. [Chest]{.underline} 125: 83S-85S, 2004.

58\. Yang, Q., Zhang, R., Wang, X.W., Linke, S. P., Sengupta, S.,
Hickson, I. D., Pedrazzi, G., Perrera, C., Stagljar, I., Littman, S. J.,
Modrich, P. and Harris, C. C.: The mismatch DNA repair heterodimer,
hMSH2/6, regulates BLM helicase in homologous DNA recombination.
[Oncogene]{.underline} 23: 3749-3756, 2004.

59\. Kim, J.W., Ye, Q.H., Forgues, M., Chen, Y., Budhu, A., Sime, J.,
Hofseth, L.J., Kaul, R. and Wang, X.W.: Cancer-associated molecular
signatures in the cirrhotic tissue samples of patients with chronic
liver disease. [Hepatology]{.underline} 39: 518-27, 2004.

60\. Budhu, A.S., Zipser, B., Forgues, M., Ye, Q.H., Sun, Z., Wang, X.
W.: The Molecular signature of metastases of human hepatocellular
carcinoma. [Oncology]{.underline} 69(S2): 2005.

61\. Zhang, Y., Wang, X.W., Yu, M.H., Nakanishi, T., Kainate, D.,
Jelovic, D., Goulbeva, O., Ross, D.D., Brodie, A. and Hamburger, A.W.
The ErbB3 binding protein Ebp1 suppresses androgen receptor-mediated
gene transcription and tumorigenesis of prostate cancer cells. [Proc
Natl Acad Sci USA]{.underline} 102, 9890-9895, 2005.

62\. Wang, W., Budhu, A., Forgues, M., and Wang, X.W. Temporal and
spatial control of nucleophosmin by the Ran/Crm1 complex in centrosome
duplication. [Nat Cell Biol]{.underline} 7: 823-830, 2005.

63\. Budhu, A.S. and Wang, X.W. Loading and Unloading: Orchestrating
Centrosome Duplication and Spindle Assembly by Ran/Crm1. [Cell
Cycle]{.underline} 4(11): 1510-1514, 2005.

64\. Spillare, E.A., Wang, X.W. and Harris, C.C. Role of DNA helicases
in p53-mediated apoptosis. [Oncogene]{.underline} 25(14): 2119-2123,
2006.

65\. Staib, F., Robles, A. I., Varticovski, L., Wang, X. W., Sirotin,
N., Zhurkin, V. B., Hofseth, L. J., Hussain, S. P., Galle, P. R. and
Harris, C. C.: The p53 tumor suppressor network is a key responder to
microenvironment components of chronic inflammation stress. [Cancer
Res.]{.underline} 65: 10255-10264, 2005.

66\. Wu, C. G., Budhu, A., Chen, S., Zhou X., Ionescu, N. C., Valerie,
K. and Wang, X. W.: Effect of Hepatitis C virus Core Protein on the
Molecular Profiling of Human B lymphocyte. [Mol Med]{.underline} 12:
47-53, 2006.

67\. Lambaa, J. K., Chen, X., Lan, L. B., Kim, J. W., Wang, X. W.,
Relling, M. V. Kazuto, Y., Watkins, P. B, Strom, S., Sun, D., Schuetz,
J. D. and Schuetz, E. G.: Increased CYP3A4 copy number in TONG/HCC cells
but not in DNA from other humans. [Pharmacogenetics and
Genomics]{.underline} 16: 415-427, 2006.

68\. Budhu, A., Forgues, M., Ye, Q. H., Jia, H. L., He, P., Zanetti, K.
A., Kammula, U. S., Chen, Y., Qin, L. X., Tang, Z. Y. and Wang, X. W.:
Prediction of metastatic potential and prognosis in hepatocellular
carcinoma based on a unique immune response signature of the liver
microenvironment. [Cancer Cell]{.underline} 10: 99-111, 2006.

69\. Budhu, A and Wang, X.W.: Role of cytokines in hepatocellular
carcinoma. [J. Leukocyte Biology]{.underline} 80: 1197-1213. 2006.

70\. Lim, M. J. and Wang, X. W.: Nucleophosmin and human cancer. [Cancer
Detection and Prevention]{.underline} 30: 481-490, 2006.

71\. Budhu, A. and Wang, X. W.: The role of nucleophosmin in
Ran/Crm1-mediated centrosome duplication. [Center for Cancer Research
Frontiers in Science]{.underline}, 5, 2006.

72\. Jia, H. L., Ye, Q. H., Qin, L. X., Budhu, A., Forgues, M., Chen,
Y., Liu, Y. K., Sun, H. C., Wang, L., Lu, H. Z., Shen, F., Tang, Z. Y.
and Wang, X. W.: Gene expression profiling reveals potential biomarkers
of human hepatocellular carcinoma. [Clin. Cancer Res]{.underline}. 13:
1133-1139, 2007.

73\. Takafuji, V., Forgues, M., Unsworth, E., Goldsmith, P. and Wang, X.
W.: An osteopontin fragment is essential for tumor cell invasion in
hepatocellular carcinoma. [Oncogene]{.underline}: April 23, 2007, \[Epub
ahead of print\].

74\. Hussain, S. P., Schwank, J., Staib, F., Wang, X. W. and Harris, C.
C.: TP53 mutations and hepatocellular carcinoma: insights into the
etiology and pathogenesis of liver cancer. [Oncogene]{.underline} 26:
2166-2176, 2007.

75\. Chen, X. C., Yu, B., Dong, J. C., Gu, Y. X., Chen, L., Wu, Q. Z.,
Hou, N. P., Liu, J. X., Xu, J. T., Jin, R. X., Jin, G. Q., Yang, X. D.,
Cao, Y. W., Tan, J. J., Zhu, B., Shen, J. C., Xu, Z., Varticovski, L.
and Wang, X. W.: A Phase II Clinical Trial with Cytotropic Heterogeneous
Molecular Lipids (CHML®) for Patients with Hepatic Malignancies.
[Anticancer Res]{.underline}, 27: 1593-1600, 2007.

76\. Budhu, A., Chen, Y., Kim, J. W., Forgues, M., Valerie, K., Harris,
C. C. and Wang, X. W.: Induction of a unique gene expression profile in
primary human hepatocytes by hepatitis C virus core, NS3 and NS5A
proteins. [Carcinogenesis]{.underline} 28: 1552-1560, 2007.

77\. Seike, M., Yanaihara, N., Bowman, E. D., Zanetti, K. A., Budhu, A.,
Kumamoto, K., Mechanic, L. E., Matsumoto, S., Yokota, J., Shibata, T.,
Sugimura, H., Gemma, A., Wang, X. W. and Harris, C. C.: Use of a
cytokine gene expression signature in lung adenocarcinoma and the
surrounding tissue as a prognostic classifier. [J. Nat. Cancer
Institute]{.underline} 99: 1257-1269, 2007.

78\. Roessler, S., Budhu, A., Wang, X. W.: Future of molecular profiling
of human hepatocellular carcinoma. [Future Oncol]{.underline}., 3:
429-439, 2007.

79\. Yoshikawa, H., Matsubara, K., Zhou, X., Okamura, S., Kubo, T.,
Murase, Y., Shikauchi, Y., Esteller, M., Herman, J. G., Wang, X. W.,
Harris, C. C.: WNT10B functional dualism: ß-catenin/Tcf-dependent growth
promotion or independent suppression with deregulated expression in
cancer. [Mol Biol Cell]{.underline}, in press.

[Chapters in Books]{.underline}

1.  Xu, B., Wang, X. W., Han, J. X. and Huang, C. C.: Cytotoxicity and
    induction of sister chromatid exchanges (SCE) in vitro by several
    antitumor drugs. In Chu, E. H. Y. and Generoso, W. M. (Eds.):
    [Mutation, Cancer and Malformation]{.underline}, Plenum, NY, 1984,
    pp. 819.

2.  Costa, M., Conway, K., Imbra, R. and Wang, X. W.: The involvement of
    heterochromatin damage in nickel-induced transformation and
    resistance. In Nieboer, E. and Antio, A. (Eds.): [Nickel and Human
    Health: Current Perspectives, Advances in Environmental Science and
    Technology]{.underline}. John Wiley and Sons, Inc., NY, 1990.

3.  Costa, M., Christie, N. T., Cantoni, O., Zelikoff, J. T.,
    Wang, X. W. and Rossman, T. G.: DNA damage by mercury compounds, a
    overview. In Suzuk (Ed): [Advances in Mercury
    Toxicology]{.underline}. Plenum, NY, 1991, pp. 255-273.

4.  Jia, L., Wang, X. W., Sun, Z. and Harris, C. C.: Interactive effects
    of p53 tumor suppressor gene and hepatitis B virus in hepatocellular
    carcinogenesis. In Tahara, E. (Ed): [Molecular Pathology of
    Gastroenterological Cancer: application to clinical
    practice]{.underline}. Springer-Verlag, Tokyo, 1997, pp. 209-218.

5.  Wang, X. W., Greenblatt, M. S. and Harris, C. C.: Molecular genetics
    of lung cancer. In Martinet, Y., Hirsch, F.R., Martinet, N.,
    Vignaud, J.-M. and Mulshine, J.L. (Eds.): [Clinical and Biological
    Basis of Lung Cancer Prevention]{.underline}. Birkhauser Verlag,
    Basel, Switzerland, 1998, pp. 117-127.

6.  Hussain, S. P., Wang, X. W., Shields, P. G. and Harris, C. C.:
    Gene-environment interactions in human cancer risk. In: [Chemicals
    in the 21^st^ century, chemicals for sustainable
    development.]{.underline} Proceedings of the Fourth Princess
    Chulabhorn International Science Congress. Bangkok, Trinity Publ.
    Co., 1999, pp. 39-49.

7.  Wang, X. W.: Abrogation of p53-induced apoptosis by the hepatitis B
    virus X gene. In Habib, N. (Ed): [Methods in Molecular Medicine,
    Hepatocellular Carcinoma Methods and Protocols]{.underline}. Humana
    Press Inc. Totowa, NJ, Vol. 45, 2000, pp. 57-70.

8.  Hofseth, L. J., Hussain, S. P., Wang, X. W. and Harris, C. C.
    Hepatocellular Cancers: Molecular biology and genetics. In
    Kelsen, D. P., Daly, J., Levin, B., Tepper, J. and Kern, S. (Eds.):
    [Principles and Practices of Gastrointestinal Oncology]{.underline}.
    Lippincott Williams & Wilkins. Philadelphia, PA, 2002, pp. 539-558.

9.  Elmore, L. W., Wang, X. W. and Harris, C. C.: Hepatocellular
    Carcinoma. In Vogelstein, B. and Kinzler, K. W. (Eds.): [The Genetic
    Basis of Human Cancer.]{.underline} 2nd Ed. New York, NY,
    McGraw-Hill, Inc., 2002, pp. 741-750.

10. Elmore, L. W., Wang, X. W. and Harris, C. C.: Hepatocellular
    Carcinoma. In Cooper, D. N. (Ed.): [Nature Encyclopedia of the Human
    Genome]{.underline}, Volume 3. London, Nature Publishing Group,
    2003, pp. 216-220.

11. Budhu, A. and Wang, X. W.: The Role of Hepatitis Viruses in Liver
    Oncogenesis. In Pandalai, S. G. (Ed.): [Recent Research Developments
    in Molecular Biology]{.underline}. Research Signpost. Research
    Singpost, Vol. 1, 2003, pp. 97-118.

12. Budhu, A. and Wang, X.W. Human hepatocellular carcinoma: New
    insights from gene expression profiling. In: F. Columbus, (Ed.):
    [Progress in Liver Cancer Research]{.underline}. Nova Science
    Publishers, Inc. In press.

13. Budhu, A. and Wang, X. W.: The functional relevance of HBx
    subcellular localization and nuclear shuttling. In: J. Kobarg,
    (Ed.): [The pleiotropic functions of the viral protein HBx in
    Hepatitis B virus infection and the development of liver
    cancer]{.underline}.Research Signpost, 2007.