**NIAID/ORD INTERNATIONAL CONFERENCE ON BURKHOLDERIA PATHOGENESIS:
Approaches and Opportunities for Research on Glanders and Melioidosis**

**Lister Hill Auditorium**

**August 2-3, 2004**

**Conference Agenda**

**Monday, August 2**

7:30 am Registration

8:15 am Welcoming Remarks

NIAID Staff

8:30 am "Clinical Overview of *B. pseudomallei* Infection"

Sharon J. Peacock

Wellcome Unit, Faculty of Tropical Medicine, Mahaidol University,
Bangkok, Thailand

9:10 am "Studies on the Pathogenesis of Melioidosis and Glanders"

Donald E. Woods

Department of Microbiology and Infectious Diseases, University of
Calgary Health Sciences Centre, Calgary, Canada

9:50 am "Phylogeny and Epidemiology of Human-Pathogenic *Burkholderia*"

John LiPuma

Department of Epidemiology, University of Michigan, Ann Arbor, Michigan,
USA

10:30 am Break

10:50 am "Structural Flexibility in the *Burkholderia mallei* Genome"

William Nierman

The Institute for Genomic Research, Rockville, Maryland, USA

11:30 am "Epidemiological and Pathogenetic Findings from the Darwin
Prospective Melioidosis Study"

Bart Currie

Menzies School of Health Research and Royal Darwin Hospital, Casuarina,
Northern Territory, Australia

12:10 pm Lunch

1:30 pm "Quorum Sensing in *Pseudomonas aeruginosa* and a Possible
Endogenous Defense against Quorum Sensing"

Everett Peter Greenberg

Department of Microbiology, University of Iowa College of Medicine, Iowa
City, Iowa, USA

2:10 pm "Quorum sensing in *Burkholderia cenocepacia*"

Pam Sokol

Department of Microbiology and Infectious Diseases, University of
Calgary Health Sciences Centre, Calgary, Canada

2:50 pm "Virulence Determinants of *Bukholderia mallei*"

David DeShazer

USAMRIID, Frederick, Maryland, USA

3:30 pm Break

3:50 pm "Bacterial persistence vs. researcher\'s perseverance: Molecular
pathogenesis of *Burkholderia cepacia*"

Miguel Valvano

Department of Microbiology and Immunology, University of Western
Ontario, London, Ontario, Canada

4:30 pm "Gone swimming\....flagella as a factor in *Burkholderia
cenocepacia* pathogenesis"

Joanna Goldberg

Department of Microbiology, University of Virginia Health System,
Charlottesville, Virginia, USA

5:10 pm Poster Session

6:00 pm Adjourn for the day

**Tuesday, August 3**

8:30 am "Microbiology of *Burkholderia mallei*"

David Waag

USAMRIID, Frederick, Maryland, USA

9:10 am "Interactions between *B. cepacia* and Phagocytic Cells"

David Speert

Division of Infectious and Immunological Diseases, University of British
Columbia, Vancouver, British Columbia

9:50 am "*Burkholderia pseudomallei* Modulates Proinflammatory Cytokine
and Antimicrobial Responses of Macrophages"

Stitaya Sirisinha

Department of Microbiology, Faculty of Science, Mahaidol University,
Bangkok, Thailand

10:30 am Break

10:50 am "Bacterial Virulence Factors and Induction of Mammalian Cell
Death: New Insights

Ananda M. Chackrabarty"

Department of Microbiology and Immunology, University of Illinois
College of Medicine, Chicago, Illinois, USA

11:30 am "The Cellular Pathogenesis of Melioidosis"

Timothy J. J. Inglis

Division of Microbiology and Infectious Diseases, PathCentre, Western
Australia

12:10 pm Lunch

1:30 pm "Genomewide Analysis of Evolution of Virulence Traits and
Regulatory Networks in *Pseudomonas aeruginosa*"

Stephan Lory

Department of Microbiology and Molecular Genetics, Harvard Medical
School, Boston, Massachusetts, USA

2:10 pm "Patterns of Large-Scale Genomic Variation in Virulent and
Avirulent *Burkholderia* Species"

May Ann Lee

Defence Medical and Environmental Research Institute, Singapore,
Republic of Singapore

2:50 pm "Glanders/Melioidosis Vaccine Development at Dstl"

Timothy Atkins

Defence Science and Technology Laboratory, Salisbury, Wiltshire, United
Kingdom

3:10 pm Breakout Sessions?

4:00 pm Conference Adjourns