# **NCI Summer Curriculum in**

# **Cancer Prevention**

**\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\***

Molecular Prevention Course

### August 2 through 6, 2004

**6001 Executive Boulevard**

**Conference Room C and D**

### Rockville, Maryland 20852

**301-435-1465**

#### 

#### *U.S. Department of Health and Human Services National Cancer Institute*

##### Agenda

#### *Public Health Service Division of Cancer Prevention*

#####  Revised, June 23, 2004

*National Institutes of Health Office of Preventive Oncology*

![](media/image1.png){width="1.075in" height="0.55in"}

# **NCI Summer Curriculum in Cancer Prevention**

## **Molecular Prevention Course**

Date: August 2 through 6, 2004

Time:![](media/image2.pct) 8:30 to 10:00 a.m.

10:30 to 12:00 p.m.

1:00 to 2:30 p.m.

Each session is a different topic and speaker

Location: Conference Room C and D

6001 Executive Boulevard

Rockville, Maryland 20852

301-435-1465

Course Presented by:

Office of Preventive Oncology Douglas L. Weed, MD, MPH, PhD, Director

Division of Cancer Prevention Stephen Hursting, PhD, MPH, Deputy
Director

National Cancer Institute Shine Chang, PhD Associate Director

NIH/DHHS Graça Dores, MD, MPH. Associate Director

6130 Executive Boulevard Susan Perkins, PhD, Associate Director

EPN, Suite 3109 Barbara Redding Program Coordinator

Bethesda, Maryland 20892-7361 Susan Winer, Program Specialist

Telephone: 301-496-8640 Lisa Poe, Program Assistant

Fax: 301-402-4863 Karen Mayer, Summer Intern

<http://cancer.gov/prevention/pob> Maya Vadiveloo, Summer Intern

**Educational Objective**

The overall objective of the course is to provide specialized
instruction in principles of molecular biology as applied in the field
of cancer prevention. The course focuses on the concepts and methods,
issues, and applications of molecular biology in cancer prevention
efforts and genetics of cancer. Participants have an opportunity to gain
a broad-based perspective of these subject areas, including basic
laboratory methodology and theory of how molecular techniques are
applied to molecular epidemiology, bionutrition, chemoprevention,
biomarkers, and translational research. Life-long learning skills
include critical appraisal of molecular approaches, methodologies, and
theory used in the field of cancer prevention.

The National Institutes of Health/Foundation for Advanced Education in
the Sciences (NIH/FAES) is accredited by the Accreditation Council for
Continuing Medical Education to provide continuing medical education for
physicians.

The target audiences are MDs and PhDs with an MPH degree, who were
selected into the Cancer Prevention Fellowship Program; MDs and PhDs
with an interest in cancer prevention and control from the NIH and the
NCI, national organizations, and foreign institutions.

If you have a disability and require any assistive device, services or
other reasonable accommodation to participate in this activity, please
contact the Office of Preventive Oncology at 301-496-8640 at least one
week in advance of the lecture date to discuss your needs.

NCI Summer Curriculum in Cancer Prevention and Control

Molecular Prevention Course

**Monday, August 2, 2004**

(8:30-10:00 am) Introduction/ Course Overview and Stephen Hursting, PhD,
MPH

> Molecular Biology Primer

Break

(10:30-12:00 pm) Cancer from a Biosystem Perspective J. Carl Barrett,
PhD

Lunch

(1:00-2:30 pm) Oncogenes, Tumor Suppressor Genes, and Michael Birrer, MD

> Other Cancer Related Genes

### **Tuesday, August 3, 2004**

(8:30-10:00 am) Cell Cycle Regulation and Apoptosis: Henry Thompson PhD

Avenues for Prevention

Break

(10:30-12:00 pm) Xenobiotic Metabolism and Cancer Susceptibility Thomas
Kensler, PhD

Lunch

(1:00-2:30 pm) Inflammation and Cancer Susan Fischer, PhD

### **Wednesday, August 4, 2004**

(8:30-10:00 am) Hormonal Carcinogenesis Robin Fuchs-Young, PhD

Break

(10:30-12:00 pm) The Immune System as a Target for Vaccine Jack Greiner,
PhD

> and Prevention Approaches

Lunch

(1:00-2:30 pm) Emerging Targets for Chemoprevention Asad Umar, DVM, PhD

### **Thursday, August 5, 2004**

(8:30-10:00) Animal Models for Cancer Prevention Studies Jeffrey Green,
MD

Break

(10:30-12:00 pm) Molecular Target Identification: Patricia Steeg, PhD

> Implication for Prevention Research

Lunch

(1:00-2:30 pm) Application of Genomics and Proteomics to Elise Kohn, MD

> Cancer Research

### **Friday, August 6, 2004**

(9:30-10:30 am) Molecular Epidemiology: The Integration of Molecular
Nathaniel Rothman, MD

> Markers into Population Studies I

Break

(10:45-12:00 pm) Molecular Epidemiology: The Integration of Molecular
Nathaniel Rothman, MD

Markers into Population Studies II

(1:00-2:30 pm) Optional: NIH Tour

Faculty

J. Carl Barrett, Ph.D.

Director

Center for Cancer Research

National Cancer Institute

Building 31, Suite 3A11

Bethesda, MD 20892

Telephone: 301-496-4345

E-mail: <barrett@mail.nih.gov>

Michael Birrer, M.D., Ph.D.

Principal Investigator

Cell and Cancer Biology Branch

Center for Cancer Research

National Cancer Institute

Key West Center, Room 300

9610 Medical Center Drive

Rockville, MD 20850

Telephone: 301-402-3128, ext. 311

E-mail: <birrerm@bprb.nci.nih.gov>

Susan Fischer, Ph.D.

Biochemist and Professor

Department of Carcinogenesis

The University of Texas

MD Anderson Cancer Center

Science Park Research Division

1808 Park Road 1C

Smithville, TX 78957

Telephone: 512-237-9482

E-mail: <smfischer@mdanderson.org>

Robin Fuchs-Young, Ph.D., B.S.

Assistant Professor of Carcinogenesis

Director, Community Outreach and

Education Program (COEP)

University of Texas

M.D. Anderson Cancer Center

Science Park Research Division

P.O. Box 389, Park Road 1C

Smithville, TX 78957

Telephone: 512-237-9547

E-mail: <rofy@sprd1.mdacc.tmc.edu>

Jeffrey E. Green. M.D.

Senior Investigator

Center for Cancer Research

National Cancer Institute

Building 41, Room C619

Bethesda, MD 20892

Telephone: 301-435-5193

E-mail: <jg155c@nih.gov>

John W. Greiner, Ph.D.

Section Chief

Laboratory of Tumor Immunology and Biology

Center for Cancer Research

National Cancer Institute

Building 10, Room 8B04

Bethesda, MD 20892-1750

Telephone: 301-496-9813

E-mail: <greinerj@mail,nih.gov>

Stephen D. Hursting. Ph.D. M.P.H.

Deputy Director

Office of Preventive Oncology

Division of Cancer Prevention

National Cancer Institute

6130 Executive Boulevard, Suite 3109

Bethesda, MD 20892-7361

Telephone: 301-402-7001

E-mail <sh63v@nih.gov>

Thomas W. Kensler, Ph.D.

Department of Environmental Health Sciences

Johns Hopkins University

Bloomberg School of Public Health

615 N. Wolfe Street

Baltimore, MD 21205

Telephone: 410-955-4712

E-mail: <tkensler@jhsph.edu>

Elise Kohn, Ph.D.

Chief

Molecular Signaling Unit

Laboratory of Pathology

Center for Cancer Research

National Cancer Institute

Building 10, Room B1B41

Bethesda, MD 20892

Telephone: 301-402-2726

E-mail: <kohne@mail.nih.gov>

Nathaniel Rothman, M.D.

Senior Investigator

Occupational Epidemiology Branch

Division of Cancer Epidemiology and Genetics

National Cancer Institute

6120 Executive Boulevard, Room 8116

Bethesda, MD 20892

Telephone: 301-496-9093

E-mail: <rothmann@mail.nih.gov>

Patricia S. Steeg, Ph.D.

Chief, Women's Cancer Section

Laboratory of Pathology

Center for Cancer Research

Co-chairperson, Molecular Targets Faculty

National Cancer Institute

Building 10, Room 2A33

Bethesda, MD 20892

Telephone: 301-402-2732

E-mail: <steegp@mail.nih.gov>

Henry Thompson, Ph.D.

Director

Cancer Prevention Laboratory

Colorado State University

111 Shepardson

Ft. Collins, CO 80523-1173

Telephone: 970-491-7748

E-mail: <henry.thompson@colostate.edu>

Asad Umar, D.V.M., Ph.D.

Program Director/Expert

Gastrointestional and Other Cancer Research Group

National Cancer Institute

6130 Executive Boulevard, Room 2143

Bethesda, MD 20892-7317

Telephone: 301-594-7671

E-mail: <umara@mail.nih.gov>