**ABSTRACT**

The developmental toxicity of gasoline with ETBE (ethyl tert butyl
ether) vapor condensate was evaluated in 25 confirmed-mated female
Crl:CD^®^(SD)IGSBR rats/exposure group at target concentrations of 0,
2000, 10,000, and 20,000 mg/m^3^ in air. The animals were exposed daily
for six hours from Gestation Day (GD) 5 through GD 20. There were signs
of slight maternal toxicity early in the exposure period as indicated by
statistically significant decreases in body weight change in the 20,000
mg/m^3^ group for the GD 8--11 interval. Statistically significant
decreases in food consumption also were evident at the GD 8-11 interval
for the 10,000 and 20,000 mg/m^3^ target concentration groups and at the
GD 11-14, and GD 5-20 intervals for the 20,000 mg/m^3^ target
concentration group. However, no statistically significant decreases in
body weights were noted at any interval in any treatment group. There
were no statistically significant differences for uterine implantation
data, external, visceral, and skeletal observations. Thus, exposure to
gasoline with ETBE vapor condensate at a target concentration of 20,000
mg/m^3^ caused slight maternal toxicity but not developmental toxicity.
Therefore the No Observable Adverse Effect Level for this study was
10,000 mg/m^3^ for maternal toxicity and 20,000 mg/m^3^ for
developmental toxicity.

i

**TABLE OF CONTENTS**

ABSTRACT i

TABLE OF CONTENTS ii

TITLE PAGE vi

APPROVAL SIGNATURES vii

PERSONNEL viii

QUALITY ASSURANCE STATEMENT ix

[Section]{.underline} [Page]{.underline}

1\. SUMMARY 1-1

2\. INTRODUCTION 2-1

STUDY INITIATION 2-1

EXPERIMENTAL START DATE 2-1

EXPERIMENTAL TERMINATION DATE 2-1

INLIFE TEST PERIOD 2-1

JUSTIFICATION FOR SELECTION OF TEST SYSTEM 2-1

JUSTIFICATION OF DOSING ROUTE 2-2

JUSTIFICATION OF DOSE SELECTION 2-2

COMPLIANCE 2-2

3\. MATERIALS AND METHODS 3-1

TEST SUBSTANCE 3-1

Substance Identification 3-1

Characterization of the Test Substance 3-1

Analysis of Mixtures 3-2

Sample Retention 3-2

Carrier 3-2

TEST SYSTEM 3-3

Test Animal 3-3

Animal Receipt Information 3-3

Quarantine and Acclimation Period 3-3

Number and Sex 3-3

Age at Initiation of Gestation 3-3

Weight at Initiation of Gestation 3-3

Animal Identification 3-4

Selection 3-4

Feed 3-4

Water 3-4

Housing 3-5

Environmental Conditions 3-5

ii

EXPERIMENTAL DESIGN 3-7

Mating 3-7

Experimental Groups 3-7

Administration of Test Substance and Exposure Schedule 3-7

The Chamber 3-7

The Test Atmosphere 3-8

Experimental Evaluation 3-8

Euthanasia and Cesarean Section 3-8

Examination of fetuses 3-9

Tissue Preservation 3-9

Records 3-9

Statistical Analysis 3-9

4\. RESULTS and CONCLUSION/DISCUSSION 4-1

CLINICAL INLIFE OBSERVATIONS AND SURVIVAL 4-1

GESTATION BODY WEIGHT 4-1

GESTATION FOOD CONSUMPTION 4-1

GROSS POSTMORTEM OBSERVATIONS 4-2

UTERINE IMPLANTATION DATA 4-2

FETAL BODY WEIGHT 4-2

FETAL OBSERVATIONS 4-2

External Observations 4-2

Visceral Observations 4-3

Skeletal Observations 4-3

EXPOSURE DATA AND CHAMBER CONDITIONS 4-4

DISCUSSION 4-5

PROTOCOL EXCEPTIONS 4-6

5\. LIST OF ABBREVIATIONS 5-1

STATISTICAL SYMBOLS AND ABBREVIATIONS 5-1

UTERINE IMPLANTATION DATA ABBREVIATIONS 5-2

FETAL EXTERNAL AND VISCERAL EXAMINATION

ABBREVIATIONS 5-2

6\. REFERENCES 6-1

**LIST OF TABLES**

[Table]{.underline} [Page]{.underline}

4-1. Mean exposure concentrations 4-4

4-2. Summary of chamber uniformity 4-4

iii

APPENDIX A

SURVIVAL BAR GRAPH A-1

APPENDIX B

GESTATION OBSERVATIONS B-1

APPENDIX C

GESTATION BODY WEIGHT C-1

APPENDIX D

GESTATION FOOD CONSUMPTION D-1

APPENDIX E

GROSS POSTMORTEM OBSERVATIONS E-1

APPENDIX F

UTERINE IMPLANTATION DATA F-1

APPENDIX G

FETAL BODY WEIGHT G-1

APPENDIX H

FETAL OBSERVATIONS H-1

APPENDIX I

INHALATION EXPOSURE DATA I-1

APPENDIX J

ANALYTICAL CHEMISTRY REPORT J-1

iv

**TABLE OF CONTENTS (CONT'D)**

APPENDIX K

STATISTICIAN'S REPORT K-1

APPENDIX L

HISTORICAL CONTROL DATA L-1

APPENDIX M

FEED AND WATER ANALYSES M-1

v

FINAL REPORT

PROJECT NUMBER: 171634

Test Substance: Gasoline WITH ETBE Vapor Condensate

(MRD-00-716)

Whole-Body Inhalation Developmental Toxicity Study in Rats

with Gasoline WITH ETBE Vapor Condensate (MRD-00-716)

PERFORMED FOR:

AMERICAN PETROLEUM INSTITUTE

1220 L Street Northwest

Washington, D.C. 20005-4070

PERFORMED AT:

EXXONMOBIL BIOMEDICAL SCIENCES, INC.

Laboratory Operations, Mammalian Toxicology Laboratory

1545 Route 22 East, P.O. Box 971

Annandale, New Jersey 08801-0971

STUDY COMPLETION DATE: TBD

vi

**APPROVAL SIGNATURES**

D. J. Devlin, Ph.D. Date

Director, Toxicology and Environmental Sciences

I hereby accept responsibility for the validity of these data and
declare that to the best of my knowledge, the study contained herein was
performed under my supervision in compliance with the EPA, United States
Environmental Protection Agency, Good Laboratory Practices (GLP)
Standards for Inhalation Exposure Health Effects Testing, 40 CFR, Part
79.60, 1994 with the following exception.

The storage of the sorbent tubes collected for the detailed capillary/GC
analysis was not documented. The tubes were stored in the necropsy
freezer after sample collection until they were transferred to the
Analytical Chemistry Group for analysis.

Water and feed analyses were not performed in a GLP compliant
laboratory.

These minor deviations from the EPA Good Laboratory Practice Standards
had no adverse effect on the integrity or results of the study.

G. W. Trimmer, B.A. Date

Study Director

T.M. Gray, M.S. D.A.B.T. Date

Sponsor

vii

**PERSONNEL**

Study Director: G. W. Trimmer, B.A.

Sponsor: American Petroleum Institute

1220 L Street Northwest

Washington, D.C. 20005-4070

Sponsor Representative: T. M. Gray, M.S., D.A.B.T.

Director, Laboratory Operations

(Study Initiation through October 31, 2004) J. J. Freeman, Ph.D.,
D.A.B.T.

Laboratory Coordinator (effective November 1, 2004): G. W. Trimmer, B.
A.

Toxicology and Animal Care Supervisor: R. C. Forgash, B.S.

Compound Preparation Supervisor: E. J. Febbo, M.S.

Analytical Chemistry Supervisor: D. J. Letinski, M.S.

Quality Assurance/Archives Section Head

(Study Initiation through February 28, 2005) W. J. Bover, Ph.D.

Quality Assurance/Archives Supervisor

(effective March 1, 2005) : R. Pristas, M.S.

Veterinarian: R. L. Harris, D.V.M.

Reproductive Toxicology Consultant: S. B. Harris, Ph.D.

Statistician: M. J. Nicolich, Ph.D

Statistician Consultant: G. Bukhbinder, Ph.D.

viii

**[DRAFT]{.underline}**

QUALITY ASSURANCE STATEMENT §

STUDY NUMBER: 171634

TEST SUBSTANCE: MRD-00-716

STUDY SPONSOR: American Petroleum Institute

Listed below are the inspections performed by the Quality Assurance Unit
of ExxonMobil Biomedical Sciences, Inc., the date(s) of inspection, and
the date(s) findings were reported to the Study Director and Management.

Study Phase Date(s) of Reported to Reported to

[Inspected]{.underline} [Inspection]{.underline} [Study
Director]{.underline} [Management]{.underline}

Protocol 05 Nov 01 05 Nov 01 06 Nov 01,

05,09 Apr 02

Allocation/"Weight" Sort 26 Apr 02 29 Apr 02 09,22 May 02

Daily/Monthly Watchdog 06 May 02 07 Aug 02 08,09 Aug 02

Procedures

In-chamber Clinical 14 May 02 14 May 02 02,04 Oct 02

Observations

Uterus Staining 16 May 02 16 May 02 21 May 02

Skeletal Examination 28 Jun 02 08 Jul 02 09,11 Jul 02

Final Report 28 Aug- 01 Oct 02 01 Oct 02 10,16 Jan 07

Historical Control 31-Oct-04 Nov 02 07 Nov 02 10,16 Jan 07

Data

Second Review of 27 Nov 06, 09 Jan 07 20,25 Jan 07

Final Report 07,08,12,28 Dec 06,

09 Jan 07

Third Review of 18,21 Apr 08 21 Apr 08 24 Apr 08

Final Report

The final report accurately reflects the methods, procedures and
observations documented in the raw data.

Robert Pristas, M.S. Date

Quality Assurance Unit Coordinator

ix

# 

**SUMMARY**

This study was conducted to evaluate the potential developmental
toxicity of the test substance, Gasoline with ETBE Vapor Condensate
(GEVC). GEVC was administered via whole-body inhalation exposure to
pregnant rats during the period of major organogenesis and fetal growth.
GEVC was administered by whole-body inhalation exposure to 25
confirmed-mated Crl:CD^®^(SD)IGSBR female rats at target concentrations
of 0 (air control), 2000, 10,000, and 20,000 mg/m^3^ for six hours (plus
the theoretical equilibration time) daily from Gestation Day (GD) 5
through GD 20. The Sponsor selected the exposure levels based upon
safety considerations and previously conducted mammalian toxicity
studies

Clinical observations were made daily during gestation. Body weight and
food consumption measurements were made on GD 0, 5, 8, 11, 14, 17, 20,
and 21. On GD 21 animals were sacrificed by CO~2~ asphyxiation followed
by exsanguination. The reproductive organs and the abdominal and
thoracic cavities were examined grossly. Uterine weights with ovaries
attached were recorded. Uterine contents were examined, and the numbers
of live, dead and resorbed fetuses were recorded. All fetuses were
weighed, sexed externally, and examined externally for gross
malformations. Apparent non-gravid uteri were placed in 10% ammonium
sulfide solution for confirmation of non-pregnancy status.

The viscera of approximately one-half of the fetuses of each litter were
examined by fresh dissection. After these fetuses were examined, they
were decapitated. The heads were preserved in Bouin\'s solution for at
least two weeks, rinsed, and subsequently stored in 70% ethanol. The
fetal heads were sectioned and examined with a dissecting microscope for
the presence of abnormalities. The remaining fetuses judged to be alive
at the C-section were eviscerated, processed for skeletal staining,
stained for bone and cartilage, and examined for the presence of
skeletal malformations and variations.

There was evidence of slight maternal toxicity in this study at the
target concentration of 20,000 mg/m^3^. A statistically significant
decrease in body weight change was evident in the 20,000 mg/m^3^ target
concentration group for the GD 8--11 interval. Statistically significant
decreases in food consumption also were evident at the GD 8-11, GD
11-14, and GD 5-20 intervals for the 20,000 mg/m^3^ target concentration
group. No statistically significant decreases in body weights were noted
at any interval in any treatment group. The only evidence of maternal
toxicity at the 10,000 mg/m^3^ target concentration was a statistically
significant decrease in food consumption on GD 8-11; this was not
considered clear evidence of maternal toxicity, since no other time
intervals were significantly affected and since there was no significant
effect on maternal body weight or body weight gain at any time interval.
All dams survived to scheduled terminal sacrifice on GD 21. At the GD 21
cesarean section, two 2000 mg/m^3^ target concentration animals, one
animal in the 10,000 mg/m^3^ target concentration group, and one animal
in the 20,000 mg/m^3^ target concentration group were found to be not
pregnant (*i.e*. no evidence of implantation sites).

All animals were free of clinical or postmortem observations
attributable to treatment with GEVC.

1-1

**SUMMARY (CONT\'D)**

There were no treatment-related statistically significant differences
between the control and the GEVC treated groups for uterine implantation
data, external observations, visceral and skeletal observations.

In conclusion, administration of GEVC to rats by whole-body inhalation
exposure during the period of organogenesis and fetal growth produced
signs of slight maternal toxicity during the early period of dosing at
the target concentration of 20,000 mg/m^3^ as indicated by decreased
body weight change and decreased food consumption. There were no
treatment related signs of toxicity in the fetuses.

Therefore, the No Observable Adverse Effect Level for maternal toxicity
was the target concentration of 10,000 mg/m^3^ and the No Observable
Adverse Effect Level for developmental toxicity in this study was
established at the target concentration of 20,000 mg/m^3^.

1-2

# 

**INTRODUCTION**

This study was conducted to evaluate the developmental toxicity of
Gasoline with ETBE Vapor Condensate (MRD-00-716) administered whole-body
inhalation exposure to pregnant rats during the period of major
organogenesis and fetal growth.

This study was conducted for the American Petroleum Institute, 1220 L
Street Northwest, Washington, D.C. 20005-4070 (subsequently referred to
as the Sponsor).

The study was conducted by ExxonMobil Biomedical Sciences, Inc. (EMBSI)
Laboratory Operations, Mammalian Toxicology Laboratory, 1545 Route 22
East, P.O. Box 971, Annandale, New Jersey 08801-0971. The EMBSI
Mammalian Toxicology Laboratory is accredited by the Association for
Assessment and Accreditation of Laboratory Animal Care (AAALAC
International).

**STUDY INITIATION (PROTOCOL SIGNATURE DATE)**

April 12, 2002

**Experimental start date**

April 27, 2002

**Experimental termination date**

July 19, 2002

**Inlife Test Period**

April 22, 2002 to May 22, 2002

**Justification for Selection of Test System**

The rat is one of the species required by the EPA for the developmental
toxicity testing requirement of Section 211b of the Clean Air Act.

2-1

**INTRODUCTION (CONT\'D)**

**Justification of Dosing Route**

Exposure by inhalation is a likely route of human exposure.

**Justification of Dose Selection**

The high dose of 20,000 mg/m^3^ was selected based on safety concerns as
one-half of the Lower Explosive Limit. The low dose (2000 mg/m^3^) was
expected to produce a No Adverse Effect Level based on the results of
previous subchronic and developmental studies conducted on this
material, related materials, or some combination thereof. The mid dose
(10,000 mg/m^3^) was selected as the approximate mid point between the
low and high doses to produce a dose response relationship, if one
existed in this treatment range.

**Compliance**

This study was conducted to meet/exceed compliance with the following
standards and requirements:

EPA, United States Environmental Protection Agency, Good Laboratory
Practices (GLP) Standards for Inhalation Exposure Health Effects
Testing. 40 CFR, Part 79.60, 1994.

EPA, United States Environmental Protection Agency, Vehicle Emissions
Inhalation Exposure Guideline. 40 CFR, Part 79.61, 1994.

Animal Welfare Act of 1966 (P.L. 89-544), as amended in 1970, 1976, and
1985. Code of Federal Regulations, Title 9 \[Animals and Animal
Products\], Subchapter A - Animal Welfare Parts 1, 2, and 3.

This study was conducted in accord with the following guidelines and
standards:

EPA, United States Environmental Protection Agency, Health Effects Test
Guidelines OPPTS 870.3600 Inhalation Developmental Toxicity Study,
Public Draft, June 1996.

EPA, United States Environmental Protection Agency, Health Effects Test
Guidelines, OPPTS 870.3700, August 1998.

OECD, Organization for Economic Cooperation and Development, Guidelines
for the Testing Chemicals, Proposal for Updating Guideline 414, Jan
2001.

Guide for the Care and Use of Laboratory Animals, Institute of
Laboratory Animal Resources, Commission on Life Sciences, National
Research Council, National Academy Press, Washington, D.C., 1996.

2-2

# 

**MATERIALS AND METHODS**

**TEST SUBSTANCE**

[Substance Identification]{.underline}

EMBSI Identification: MRD-00-716

Sponsor Identification: Gasoline with ETBE Vapor Condensate

Supplier: Chevron Research and Technology Company

Lot #: API 01-05

Description: Colorless liquid

Storage Condition: Ambient outdoor conditions under nitrogen

Date Received: Container numbers^a^: Expiration Date:

September 17, 2001 1A (2 ^b^), 2A (2 ^b^), 3A (2 ^b^),

4A (2 ^b^) September 30, 2006

^a^ - Numbers in () are the Supplier\'s tank identification numbers

^b^ - Large cylinder number

[Characterization of the Test Substance]{.underline}

The stability, identity, strength, purity, and composition or other
characteristics that appropriately identified the test substance was
performed by the testing laboratory (EMBSI). Documentation is maintained
at ExxonMobil Biomedical Sciences, Inc., Annandale, New Jersey.
Characterization will be reported as part of EMBSI Study 167490.
Additionally, Appendix J shows the stability of the test substance over
the course of the exposure interval.

The documentation of methods of synthesis, fabrication, and/or
derivation of the test fuel were the responsibility of the Sponsor. This
was not completed when the study initiated, but is currently with the
Sponsor.

[3-1]{.underline}

**TEST SUBSTANCE (CONT\'D)**

[Analysis of Mixtures]{.underline}

[Nominal Concentration.]{.underline} A nominal exposure concentration
was calculated on a daily basis. The net weight of test substance used
was determined and was divided by the total volume of air passing
through the chamber to give the nominal concentration.

[Analytical Concentration.]{.underline} The concentration of the test
atmosphere in each chamber and the chamber room was determined
approximately hourly during each exposure by on-line gas chromatography.
The chamber concentrations were measured in the breathing zone of the
rats. A backup analytical device (calibrated infrared vapor monitor) was
also available. The hourly chromatographic analyses showed five major
components of the test atmosphere and were used to assess the stability
of the test substance over the duration of the study.

Additionally, a sorbent tube sample of the test atmosphere was collected
by drawing a known volume of the test atmosphere from each chamber
through a calibrated critical orifice once during each week of the
study. These samples were stored in a freezer until after the end of the
exposure phase of the study and then transferred to the analytical
chemistry laboratory. The samples were desorbed and analyzed by the
detailed capillary/GC method used for the initial characterization
analysis of the liquid test substance. This analysis was done to
determine component proportions of the test material atmosphere compared
to the liquid test material.

[Chamber Homogeneity.]{.underline} Distribution samples were drawn from
twelve different points within the chamber at each exposure level during
the validation of the exposure system for this study.

[Particle Size Analysis.]{.underline} A particle size determination of
the aerosol portion of the test atmosphere was conducted from the
control and 20,000 mg/m^3^ target concentration during the chamber
trials. The sample was taken using a multistage cascade impactor.
Preweighed glass fiber filters were used to collect aerosol on each
stage, which are associated with specific cutoff diameters for
aerodynamic particle size in microns. Since minimal aerosol was present,
no further calculations were performed for the aerodynamic diameter,
geometric standard deviation, or the estimated percents of the aerosol
less than or equal to 1, 10, and 15 microns in size.

[Sample Retention]{.underline}

No retention samples were taken due to the practical and safety
considerations of storing a mixed gas/liquid phase substance under
pressure.

[Carrier]{.underline}

Air

3-2

**TEST SYSTEM**

[Test Animal]{.underline}

Species: Rat

Strain/stock: Crl:CD^®^(SD)IGSBR VAF/Plus

Supplier: Charles River Laboratories, Inc.

Raleigh, North Carolina

[Animal Receipt Information (Females)]{.underline}

Receipt Date: April 2, 2002

Shipping Reference Number: 70223589

[Quarantine and Acclimation Period]{.underline}

25 days; animals were checked for viability at least once daily.

[Number and Sex]{.underline}

150 sexually mature virgin females

100 females were allocated to study groups after confirmation of mating;
the additional 50 females were ordered to assure there would be 100
mated females and to make the mating as efficient as possible without
exceeding the necropsy capacity of the laboratory.

50 sexually mature males (12-13 weeks old at the initiation of mating)
received for mating purposes from a different colony than the females to
assure they were not siblings. These rats were also used for mating with
at least one other study. The males also were received on April 2, 2002.

[Age at Initiation of Gestation (Designated GD 0)]{.underline}

Females: 14 -- 15 weeks

[Weight at Initiation of Gestation (Designated GD 0)]{.underline}

Females: 240 to 299 grams

3-3

**TEST SYSTEM (CONT\'D)**

[Animal Identification]{.underline}

Individual ear tags and corresponding cage identification.

[Selection]{.underline}

More animals than required for the conduct of the study were purchased
and acclimated. Animals determined to be unsuitable for inclusion on
this study because of poor health, outlying body weights, or other
abnormalities were excluded from selection by the Study Director, and/or
technical staff.

[Feed]{.underline}

Certified Rodent Diet Meal 5002, *ad libitum*

Manufacturer: PMI Nutrition International, LLC (formerly PMI Feeds,
Inc.)

Richmond, Indiana

Analysis: Performed by PMI Nutrition International, LLC. Copies of the
feed analyses are maintained in the EMBSI Toxicology Laboratory. The
feed analyses were not conducted by a GLP-compliant laboratory.

Contaminants: There were no known contaminants in the feed believed to
have been present at levels that may have interfered with this study.

The availability of feed was checked daily for all animals. Animals were
without food while in the exposure chambers.

[Water]{.underline}

Automatic watering system, *ad libitum*

Supplier: ExxonMobil Research and Engineering Clinton Facility
De-ionized Water System.

Analysis: Periodic analysis is the responsibility of the testing
laboratory. A copy of the results is maintained at the testing
laboratory. The analysis was not performed in a GLP-compliant
laboratory.

Contaminants: There were no known contaminants in the water believed to
have been present at levels that may have interfered with this study.

The availability of water was checked daily for all animals. Animals
were without water while in the exposure chambers.

3-4

**TEST SYSTEM (CONT\'D)**

[Housing]{.underline}

Room Number: PE103

Chamber rooms: PE102, PE110

Housing: Single housed during the study period, except during mating.

Caging: Suspended stainless steel and wire mesh with absorbent paper
below cages.

[Environmental Conditions]{.underline}

Animal Room

Temperature: 66.5 to 71.9 degrees Fahrenheit

Humidity: 34.7 to 97.6 percent relative humidity (see Protocol
Exceptions)

Lighting: Approximately 12 hours light (0600 to 1800 hours) and 12 hours
dark (1800 to 0600 hours) by automatic timer.

A computerized system monitored the temperature, humidity, and lighting
continuously.

Chambers

Temperature: 64 to 78 degrees Fahrenheit (see Protocol Exceptions and
Appendix I)

Humidity: 42 to 100 percent relative humidity (see Protocol Exceptions
and Appendix I)

Temperature and humidity were monitored continuously and recorded
approximately every 30 minutes during the exposure.

Light Intensity

Animal Room Light Intensity: 3.8 to 8.9 foot-candles

Chamber Room Light Intensity: 28.9 to 62.0 foot-candles

Light intensity was measured three times during the study (the first day
of exposures, during the second week of exposures and the last day of
exposures) in both the animal room and the chamber room. Light intensity
was measured in the animal room in a cage approximately three feet above
the floor level. In the chamber room the light intensity was measured
three feet above floor level in the approximate center of each
generation room.

3-5

**TEST SYSTEM (CONT\'D)**

[Environmental Conditions (cont'd)]{.underline}

Chamber Noise Levels and Oxygen Levels

Noise Level: 72.2 to 80.2 db

Oxygen Level: 19.7 to 20.7%

The oxygen level and the noise level were measured in each exposure
chamber on the first day of exposures, during the second week of
exposures and on the last day of exposures.

3-6

**EXPERIMENTAL DESIGN**

[Mating]{.underline}

On the initial scheduled mating day, females were placed in males\'
cages in a 1:1 (male:female) ratio. Males and females were paired based
on sequential Physical Identification Numbers. A sufficient number of
animals were co-housed in an attempt to produce an acceptable number of
mated animals to accommodate lab scheduling. Mating was confirmed on the
following morning by observation of a copulatory plug (vaginal). The day
on which mating was confirmed was considered Day 0 of gestation (GD 0).
After confirmation of mating, each mated female was returned to its own
cage. New females then were placed in the males\' cages until the
required number of mated females was obtained by continuous cohabitation
in consideration of lab scheduling. Mated females subsequently were
assigned to dose groups by a computer generated body weight sorting
program (WEIGHT) using the GD 0 body weights to ensure mean body weight
was similar between all groups on GD 0.

[Experimental Groups]{.underline}

+------------------------------+---------------------+----------------+
| Group                        | Number of Females   | Target Dose    |
|                              | per Group           |                |
| Number                       |                     | (mg/m^3^)      |
+------------------------------+---------------------+----------------+
| 1\. (Carrier Control)        | 25                  | 0              |
+------------------------------+---------------------+----------------+
| 2\. Low                      | 25                  | 2000           |
+------------------------------+---------------------+----------------+
| 3 . Intermediate             | 25                  | 10,000         |
+------------------------------+---------------------+----------------+
| 4 . High                     | 25                  | 20,000         |
+------------------------------+---------------------+----------------+

[Administration of Test Substance and Exposure Schedule]{.underline}

The experimental and control animals were placed (whole body) into 1.0
M^3^-inhalation chambers that were operated under dynamic conditions.
The exposure period was six hours per day. The test substance atmosphere
generation system was started after the last animal was placed in the
exposure chambers and the generation system was stopped six hours later.
The animals remained in the chambers for at least an additional 23
minutes (theoretical equilibration time) while the test atmosphere
cleared. The animals were exposed from GD 5 through GD 20.

[The Chamber]{.underline}

The chambers used for exposure are stainless steel and glass and have a
total volume of approximately 1.0 M^3^. They operated at a flow rate
(approximately 12 air changes/hour) sufficient to ensure timely
equilibration. The flow of air through each chamber was monitored
continuously using a calibrated flow measuring device and recorded
approximately every 30 minutes. All chambers were maintained at a slight
negative pressure. The pressure was monitored continuously and recorded
approximately every 30 minutes.

3-7

**EXPERIMENTAL DESIGN (CONT\'D)**

[The Test Atmosphere]{.underline}

The control group was exposed to clean filtered air under conditions
identical to those used for groups exposed to the test substance. The
test substance was administered fully vaporized in the breathing air of
the animals. The test atmosphere composition and concentration remained
constant at each exposure level over the daily six-hour period. The
daily mean exposure concentrations generally were within [±]{.underline}
10% of the target exposure levels with the exceptions listed in the
Protocol Exceptions section.

[Experimental Evaluation]{.underline}

Animals were examined for viability at least twice daily during the
study. Body weights were taken prior to selection, and on GD 0, 5, 8,
11, 14, 17, 20, and 21. Food consumption was measured for mated females
on GD 5, 8, 11, 14, 17, 20, and 21. A clinical examination was given to
each female prior to selection, and daily during gestation.
Additionally, group observations of the animals for mortality and
obvious toxic signs while in the chambers were recorded at 15, 30, 45,
and 60 minutes after initiation of the exposure and then hourly during
each exposure.

[Euthanasia and Cesarean Section]{.underline}

Euthanasia of the dams was by CO~2~ asphyxiation followed by
exsanguination. A gross necropsy was performed on all confirmed-mated
females.

The fetuses were placed in a refrigerator to slow down and eventually
terminate vital signs after the external examination and weighing.

Mated females were euthanized on GD 21. Body weights were recorded on
the day of necropsy. Uterine weights with ovaries attached were recorded
at the time of necropsy. Uterine contents were examined and the numbers
and locations of implantation sites, early and late resorptions, live
and dead (alive or dead *in utero*) fetuses were counted. Corpora lutea
also were counted. The uteri of all apparently non-pregnant females were
stained with 10% ammonium sulfide to confirm pregnancy status.

Evaluations of dams during cesarean section and subsequent fetal
evaluations were conducted without knowledge of treatment group in order
to minimize bias.

3-8

**EXPERIMENTAL DESIGN (CONT\'D)**

[Examination of Fetuses]{.underline}

Each live fetus (alive *in utero*) was weighed and examined externally
for gross malformations. Fetal sex was determined by external
examination and confirmed internally only on those fetuses receiving
visceral examinations.

Prior to visceral examinations any live fetuses were euthanized by a
subcutaneous injection with sodium pentobarbital. The viscera of
approximately one-half of the live fetuses (alive *in utero*) of each
litter were examined by fresh dissection (Staples, 1974; Stuckhardt and
Poppe, 1984). After these fetuses were examined, they were decapitated.
The heads were preserved in Bouin\'s solution for at least two weeks,
then rinsed and subsequently stored in 70% ethanol. Free-hand razor
blade sections of the Bouin\'s-fixed fetal heads were examined for the
presence of abnormalities. The remaining live fetuses (alive *in utero*)
were eviscerated, processed by double staining with Alizarin red and
Alcian blue, and examined for the presence of bone and cartilage
malformations and ossification variations.

Fetus #2 of Dam IGL353 in the 2000 mg/m3 target concentration group was
a conjoined twin that was examined for both visceral and skeletal
anomalies.

Fetal evaluations were conducted without knowledge of treatment group in
order to minimize bias.

[Tissue Preservation]{.underline}

Fetal heads were fixed in Bouin\'s solution and then preserved in 70%
ethanol. The fetal skeletons were preserved in glycerine with thymol
after they were processed and stained.

[Records]{.underline}

A copy of the protocol, final report, raw data, computer generated
listings of raw data, supporting documentation, and tissue specimens
were maintained in the EMBSI Toxicology Laboratory Archives until they
were returned to the Sponsor.

[Statistical Analysis]{.underline}

Statistical evaluation of equality of means was done by an appropriate
one way analysis of variance and a test for ordered response in the dose
groups. First, Bartlett\'s Test was performed to determine if the dose
groups had equal variance (Snedecor and Cochran, 1989). If the variances
were equivalent, the hypothesis that there was no difference in response
between the groups was tested using a standard one-way analysis of
variance (Snedecor and Cochran, 1989). If the variances were equal, the
testing was done using parametric methods, otherwise nonparametric
techniques were used.

3-9

**EXPERIMENTAL DESIGN (CONT\'D)**

[Statistical Analysis (Cont\'d)]{.underline}

Continuous data were tested for statistical significance as follows:
Where applicable, percentages were calculated and transformed by
Cochran\'s transformation, followed by the arc sine transformation
(Snedecor and Cochran, 1989). The raw percentages and the transformed
percentages both were tested for statistical significance.

For the parametric procedures, a standard one way ANOVA using the F
distribution to assess significance was used (Snedecor and Cochran,
1989). If significant differences among the means were indicated,
Dunnett\'s Test was used to determine which treatment groups differed
significantly from control (Dunnett, 1964). In addition to the ANOVA, a
standard regression analysis for linear response in the dose groups was
performed. The regression also tested for linear lack of fit in the
model.

For the nonparametric procedures, the test of equality of means was
performed using the Kruskal-Wallis Test (Hollander and Wolfe, 1973). If
significant differences among the means were indicated, Dunn\'s Summed
Rank Test was used to determine which treatment groups differed
significantly from the control (Hollander and Wolfe, 1973). In addition
to the Kruskal-Wallis Test, Jonckheere\'s Test for monotonic trend in
the dose response was performed.

Bartlett\'s Test for equal variance was conducted at the 1% level of
significance. All other tests were conducted at the 5% and 1% level of
significance. However, the 5% level of significance was considered
statistically significant for these analyses. The 1% level of
significance was reported as additional information.

The following data were not included in the statistical analyses:

-   Gestation body weight and body weight change data for females that
    were not pregnant

-   Gestation food consumption for females that were not pregnant

Means and standard deviations were calculated for animal, exposure and
chamber environmental data. The coefficient of variation also was
calculated when considered relevant for the exposure data.

3-10

**EXPERIMENTAL DESIGN (CONT\'D)**

[Statistical Analysis (Cont\'d)]{.underline}

Fetal body weight was analyzed by a mixed model analysis of variance
that provided an accurate statistical model of the biology. The analysis
used the litter as the basis for analysis and effectively used the
litter size as a covariate. The model considered dose group, litter
size, and fetal sex as explanatory variables. If the overall effect of
dose, or the dose by sex effect, was statistically significant the dose
groups means were tested pairwise vs. the control group using least
squares means. The least squares means allowed comparisons that
accounted for differences in litter size and sex. The mathematical model
was based on a paper by Chen, et al (1996). The analysis was run using
SAS with code suggested in Little, et al (1997).

The analysis of anomalies (malformations or variations) was based on a
Generalized Estimating Equation (GEE) application of the linearized
model, Ryan (1992). The model used the litter as the basis for analysis
and considered correlation among littermates by incorporating an
estimated constant correlation and the litter size as a covariate. If
the overall effect of dose, or the dose by sex effect, was statistically
significant the dose groups were tested pairwise vs. the control group
using least squares means. The least squares means allowed comparisons
that accounted for differences in litter size. Three categories of
anomalies were tested, and within each category specific anomalies also
were tested. In addition to the category specific anomalies a series of
combined analyses were performed within each category as applicable:

Combined Malformations and Variations for All Fetuses

Combined Malformations and Variations for Alive Fetuses

Combined Malformations and Variations for Dead Fetuses

Malformations for All Fetuses

Malformations for Alive Fetuses

Malformations for Dead Fetuses

Variations for All Fetuses

Variations for Alive Fetuses

Variations for Dead Fetuses

Combined -- All Fetuses with Supernumerary Ribs

Combined -- All Fetuses with Hypoplastic Sternabrae

Combined -- All Fetuses with Hypoplastic Vertebral Centra

[3-11]{.underline}

# 

**RESULTS AND CONCLUSIONS/DISCUSSION**

**CLINICAL INLIFE OBSERVATIONS AND SURVIVAL**

Survival Bar Graph: Appendix A

Incidence of Gestation Observations: Appendix B

Individual Gestation Observations: Appendix B

All dams survived to scheduled terminal sacrifice on GD 21. At the GD 21
cesarean section two 2000 mg/m^3^ target concentration animals, one
animal in the 10,000 mg/m^3^ target concentration group and one animal
in the 20,000 mg/m^3^ target concentration group were found to be not
pregnant (*i.e*. no evidence of implantation sites).

There were no clinical signs indicative of maternal toxicity
attributable to the test material. The majority of dams in all dose
groups were free of observable abnormalities during the entire gestation
period. Clinical signs were limited to alopecia of the trunk for three
control dams and one dam from the 20,000 mg/m^3^ target concentration
group, and alopecia of the extremities was evident in one dam for the
10,000 mg/m^3^ target concentration group. Clinical signs were not
evident in the 2000 mg/m^3^ target concentration dams.

**GESTATION BODY WEIGHT**

Mean Gestation Body Weight and Body Weight Change: Appendix C

Individual Gestation Body Weight and Body Weight Change: Appendix C

A statistically significant decrease in body weight change was evident
in the 20,000 mg/m^3^ target concentration group for the GD 8-11
interval. However, no statistically significant decreases in body
weights were noted at any interval in any treatment group compared to
controls. Additionally, statistically significant linear trends
(decreases) were detected in body weight change for the GD 5-8, GD 8-11,
GD 11-14, and GD 0-21C intervals and in the body weight for GD 14. No
other differences in body weight change were evident.

**GESTATION FOOD CONSUMPTION**

Mean Gestation Food Consumption: Appendix D

Individual Gestation Food Consumption: Appendix D

Statistically significant decreases in food consumption were evident at
the GD 8-11 interval for the 10,000 and 20,000 mg/m^3^ target
concentration groups and at the GD 11-14, and GD 5-20 intervals for the
20,000 mg/m^3^ target concentration group. Additionally, statistically
significant linear trends (decreases) were detected in food consumption
for the GD5-8, GD 8-11, GD 11-14, GD 17-20, GD 5-20, and GD 0-21
intervals. No other differences in food consumption were evident.

4-1

**GROSS POSTMORTEM OBSERVATIONS**

Incidence of Gross Postmortem Observations: Appendix E

Individual Gross Postmortem Observations: Appendix E

The gross postmortem examination of the dams revealed a diverticulum of
the right horn of the uterus that was filled with liquid for one control
dam. Alopecia of the trunk was evident for three control dams and one
20,000 mg/m^3^ target concentration dam. All other dams were free of
grossly observable abnormalities.

**UTERINE IMPLANTATION DATA**

Mean Uterine Implantation Data: Appendix F

Individual Uterine Implantation Data: Appendix F

There were no statistically significant differences in the uterine
implantation parameters between the control and the treated groups.

**FETAL BODY WEIGHT**

Mean Fetal Body Weight: Appendix G

Individual Fetal Body Weight: Appendix G

Statisticians Report: Appendix K

There were no statistically significant decreases in mean fetal body
weight between the control and the treated groups.

**FETAL OBSERVATIONS**

Incidence of Fetal Observations: Appendix H

Individual Fetal Observations: Appendix H

Statistician's Report: Appendix K

There were no statistically significant or treatment-related differences
between the control and the treated groups for visceral and skeletal
variations and/or malformations. There was a statistically significant
decrease in the incidence of external variations and malformations in
the 10,000 and 20,000 mg/m^3^ target exposure groups. These decreases
were not considered indicative of developmental toxicity produced by
exposure to GEVC.

4-2

**FETAL OBSERVATIONS (CONT\'D)**

[External Observations]{.underline}

The incidences of external observations are presented in Appendices H
and K. No malformations or variations were observed during the external
examination in the 10,000 and 20,000 mg/m^3^ target exposure groups.
There was a statistically significant decrease in the incidence of
external variations and malformations in the 10,000 and 20,000 mg/m^3^
target exposure groups compared to controls; these decreases were not
considered indicative of developmental toxicity produced by exposure to
GEVC. At the 2000 mg/m^3^ target concentration, the only external
malformation was a conjoined twin in one litter (Dam IGL353, Fetus #2).
Among the controls, there were two fetuses with malrotated hindpaw, one
fetus with domed head, and one dead fetus with multiple external
malformations; four control litters were affected.

[Visceral Observations]{.underline}

The incidences of visceral observations are presented in Appendices H
and K. The incidences of visceral malformations and variations did not
differ significantly from the control incidences. Fetus #2 of Dam IGL353
in the 2000 mg/m3 target concentration group was a conjoined twin that
had shared organs, small spleen, cecum not evident, small left
ventricle, a duplicate tongue, two aortas, elongated innominate,
supernumerary lobe of the lung, malpositioned carotid artery,
malpositioned subclavian artery, and malpositioned pulmonary artery.
Visceral observations in the other fetuses in the study were minimal and
were limited to low incidences of umbilical artery arises from left,
hydroureter, hydronephrosis, and retinal fold. Single incidences of
misshapen spleen, large atrial chamber, absent innominate artery, open
eye, and umbilical artery aneurysm, malpositioned carotid artery, and
malpositioned subclavian artery.

[Skeletal Observations]{.underline}

The incidences of skeletal observations are presented in Appendices H
and K. The incidences of skeletal malformations and variations did not
differ significantly from the control incidences. The most frequently
noted skeletal ossification variants were rudimentary lumbar ribs, bifid
centra of the thoracic vertebrae, dumbbell-shaped thoracic centra
anlage, and advanced ossification of the sternebrae.

4-3

**EXPOSURE DATA AND CHAMBER CONDITIONS**

Summary of Exposure Data: Appendix I

Analytical Chemistry Report -- Appendix J

The range of chamber concentrations for the exposure period as
represented by the daily mean analytical data and nominal data of each
day are listed in Table 4-1:

Table 4-1 - Mean Exposure Concentrations (Analytical and Nominal)

  --------------- ------------ --------- ------------ ---------- ------------ ---------
  Target          2000 mg/m^3^           10,000                  20,000       
  concentration                          mg/m^3^                 mg/m^3^      

                  Analytical   Nominal   Analytical   Nominal    Analytical   Nominal

  Mean            1988         1999      10327        10379      20541        19469

  S.D.            87.7         124.2     280.2        293.4      518.3        314.5

  Minimum         1733         1736      9762         9388       19785        18799

  Maximum         2179         2375      10736        10789      21646        20071
  --------------- ------------ --------- ------------ ---------- ------------ ---------

S.D. - Standard deviation

Satisfactory chamber uniformity was observed for the 12 points in the
chamber that were analyzed. The range of concentrations for each chamber
are listed in Table 4-2.

Table 4-2 - Summary of Chamber Uniformity

  ----------------- ----------------- ----------------- -----------------
  Target            2000 mg/m^3^      10,000 mg/m^3^    20,000 mg/m^3^
  concentration                                         

  Mean              2058              10611             21233

  S.D.              126.86            206.70            248.71

  CV (%)            6.16              1.95              1.17

  Minimum           1886              10373             20832

  Maximum           2270              10997             21550
  ----------------- ----------------- ----------------- -----------------

S.D. - Standard deviation

CV - Coefficient of variation

The particle size determination for the control chamber and 20,000
mg/m^3^ target concentration chamber detected particles at a level of 0
and 20 mg/m^3^ for each chamber, respectively. These particles were
judged to be ambient background particles (*e.g*. animal dander) and not
from the generation of the test substance.

The oxygen levels in the chambers ranged from 19.7 to 20.7% at the
intervals when they were monitored. The noise level in the chambers
ranged from 72.2 to 80.2 db. The light intensity in the chamber room
ranged from 28.9 foot-candles to 62 foot candles.

The analyses of the chamber atmospheres by the analytical chemistry
group revealed that the concentrations of the components of GEVC were
stable over the course of the study. The components present in the
highest concentrations in GEVC were isopentane (\~32%), ETBE (\~17%),
n-pentane (\~10%), n-butane (\~9.5%), and 2-methylpentane (\~5%). Each
of the remaining components comprised less than 5% of the mixture (See
Appendix J for the results of the analyses).

4-4

**DISCUSSION**

There were signs of slight maternal toxicity early in the exposure
period as indicated by a statistically significant decrease in body
weight change in the 20,000 mg/m^3^ target concentration group for the
GD 8--11 interval. Statistically significant decreases in food
consumption also were evident at the GD 8-11, GD 11-14, and GD 5-20
intervals for the 20,000 mg/m^3^ target concentration group. However, no
statistically significant decreases in body weights were noted at any
interval in any treatment group. The only evidence of maternal toxicity
at the 10,000 mg/m^3^ target concentration was a statistically
significant decrease in food consumption on GD 8-11. Based on the lack
of statistically significant decreases in mean body weight and mean body
weight change for any interval in the 10,000 mg/m^3^ target
concentration group, it would appear that the decrease in food
consumption during a single interval in the 10,000 mg/m^3^ target
concentration group was not biologically significant. Conversely, the
statistically significant decreased food consumption in the 20,000
mg/m^3^ target concentration group was associated with a decrease in the
body weight change in the GD 8-11 interval and was considered
biologically significant.

There were no statistically significant differences attributable to
exposure for uterine implantation data, and external, visceral, and
skeletal observations.

In conclusion, administration of GEVC to rats by whole-body inhalation
exposure during the period of organogenesis and fetal growth at a target
concentration of 20,000 mg/m^3^ target concentration caused slight
maternal toxicity as indicated by decreased food consumption and
decreased body weight change. No developmental toxicity attributable to
the test material was observed at any level of exposure to GEVC.

Therefore, the No Observable Adverse Effect Level for maternal toxicity
was 10,000 mg/m^3^ target concentration and the No Observable Adverse
Effect Level for developmental toxicity in this study was established at
the target concentration of 20,000 mg/m^3^.

4-5

**PROTOCOL EXCEPTIONS**

ANIMAL ROOM HUMIDITY; The animal room humidity was outside the
protocol-defined ranged at the following times:

Date Humidity (%RH) Alarm Time Time resolved

May 7, 2002 71.3 16:01 Immediately

May 13, 2002 71.9 15:09 15:28

May 14, 2002 97.6 12:47 13:00

The causes of the excursions on May 7 and May 13, 2002 were unknown. The
excursion on May 14, 2002 was caused by the equilibration of a new
humidity transmitter that was placed in the system to replace the
existing transmitter.

These short excursions had no effect on the study results or integrity.

MEAN CHAMBER CONCENTRATION: The mean chamber concentration for the 2000
mg/m^3^ target concentration treatment group chamber was 1733 on April
27, 2002. This deviation was due to problems with the rotameter.

CHAMBER TEMPERATURE AND HUMIDITY: Due to the method used to generate the
test substance atmospheres, the chamber-room air was kept as cool as
possible to keep the temperature in the 10,000 mg/m^3^ and the 20,000
mg/m^3^ target concentration chambers from exceeding the
protocol-defined range. The cooler room air resulted in three instances
of the temperature in the control chamber being below the
protocol-defined range and numerous instances of the temperature in the
treated group chambers exceeding the protocol-defined ranges early in
the daily exposures. The decreased temperature also caused the humidity
in the control chamber to be above the protocol-defined range on
numerous occasions and also caused the humidity in the treated group
chambers to be above the protocol-defined range early in the daily
exposure periods on numerous occasions. The very high humidities noted
early in the daily exposures were due to the chambers not being
completely dry from the previous days cleaning. The individual
temperature and humidity deviations are noted in Appendix I as bold
italicized values.

These deviations had no adverse effect on the study results or
integrity.

No other circumstances occurred that would have affected the quality or
integrity of the data.

4-6

#  

**LIST OF ABBREVIATIONS**

**STATISTICAL SYMBOLS AND ABBREVIATIONS**

[No difference]{.underline} [p0.05]{.underline} [p0.01]{.underline}
[Statistical Statement]{.underline}

(PARAMETRIC)

A- No statistical difference among the means

A A+ Significant difference among the means

L- No linear response to the dose levels

L L+ Response is linearly related to dose

Q Q+ Linear response shows lack of fit

\* \*\* Mean significantly different from control

mean

(NONPARAMETRIC)

K- No statistical difference among the means

K K+ Means differ significantly

J- No ordered response to the dose levels

J J+ An ordered response to the dose levels

\* \*\* Mean significantly different from control

mean

NT Data not tested

5-1

**LIST OF ABBREVIATIONS**

**UTERINE IMPLANTATION DATA ABBREVIATIONS**

[ABBREVIATION]{.underline} [PARAMETER]{.underline}

Resorp Resorptions (early and late)

Implants Implantation sites

CL Corpora Lutea

Preimplant Pre implantation loss = (corpora lutea - implantation
sites)/corpora lutea x 100

Postimplant Post implantation loss = (implantation sites - total
live)/implantation sites x 100

Mal Fetuses with malformations

Var Fetuses with variations

Affected Resorptions + dead + malformations

F/I Tran Fetuses/implantation sites transformed

R/I Tran Resorptions/implantation sites transformed

D/I Tran Dead/implantation sites transformed

**FETAL EXTERNAL AND VISCERAL EXAMINATIONS**

\+ = No observable abnormalities

Stunted = Any fetus weighing less than 4.00 grams

[Organs and tissues examined]{.underline}

External: General body size, contour, and integrity (e.g.
head,spine,abdomen); limbs;

> digits; pinnae; eye bulges; palate/lip; tongue; snout/jaw; anogenital
> region; tail

Visceral: Urogenital system; adrenals; stomach; spleen; pancreas;
thymus; large/small

Intestines; liver; lungs; heart and associated major vessels; thyroid;
trachea;

Esophagus; brain ventricles (single free-hand razor section)

Malformations are anomalies that will not allow the fetus to survive
beyond parturition. Malformations are indicated by a capitalized
footnote (e.g. \"A\").

Developmental variations are anomalies that will not affect the
postnatal survival of the fetus. Developmental variations are indicated
by a lower case footnote (e.g. \"a\").

Observations are anomalies that generally are non-specific anomalies
such as stunted, pale coloration or discoloration of tissues, etc. They
are indicated by an asterisk (e.g. \"\*\").

5-2

# 

**REFERENCES**

Animal Welfare Act of 1966 (P.L. 89-544), as amended in 1970, 1976, and
1985. Code of Federal Regulations, Title 9 \[Animals and Animal
Products\], Subchapter A -Animal Welfare Parts 1, 2, and 3.

Chen, J.J., Gaylor, J.B. and Laborde, D.W. "Dose-response modeling of
growth for developmental toxicity", Environmetrics, vol 7, pg 135-144,
1996.

Dunnett, C., New Tables for Multiple Comparisons with a Control,
[Biometrics]{.underline} 20, 1964, pp. 482-491.

EPA, United States Environmental Protection Agency, Good Laboratory
Practices (GLP) Standards for Inhalation Exposure Health Effects
Testing. 40 CFR, Part 79.60, 1994.

EPA, United States Environmental Protection Agency, Vehicle Emissions
Inhalation Exposure Guideline. 40 CFR Part 79.61, 1994.

EPA, United States Environmental Protection Agency, Health Effects Test
Guidelines OPPTS 870.3600 Inhalation Developmental Toxicity Study,
Public Draft, June 1996.

EPA, United States Environmental Protection Agency, Health Effects Test
Guidelines, OPPTS 870.3700, August 1998.

Guide for the Care and Use of Laboratory Animals, Institute of
Laboratory Animal Resources, Commission on Life Sciences, National
Research Council, National Academy Press, Washington, D.C., 1996.

Hollander, M. and Wolfe, D.A. [Nonparametric Statistical
Methods]{.underline}, John Wiley and Sons, New York, 1973.

Little, Milliken, Stroup, and Wolfinger, "SAS System for Mixed Models",
SAS Institute, Cary, NC, 1997, section 5.6.2, pg 203.

OECD, Organization for Economic Cooperation and Development, Guidelines
for the Testing of Chemicals, Proposal for Updating Guideline 414,
January 2001.

6-1

**REFERENCES (CONT\'D)**

Ryan, L., "The use of generalized estimating equations for risk
assessment in developmental toxicity", Risk Analysis, 12(3), pg 439-447,
1992.

SAS/STAT, V8.02, copyright © 1999-2001, SAS Institute, Inc., Cary, NC.

Snedecor, G.W., and Cochran, W.G., [Statistical Methods]{.underline},
8th ed., Iowa State University Press, Ames, Iowa, 1989.

Staples, R.E., Detection of Visceral Alterations in Mammalian Fetus,
[Teratology]{.underline}, 9:A-37, 1974.

Stuckhardt, J.L. and Poppe, S.M., Fresh Visceral Examination of Rat and
Rabbit Fetuses Used in Teratogenicity Testing, [Terato. Carcino.
Mutagen.,]{.underline} 4, 1984, pp. 181-188.

6-2

  ---------------------- -------- ------------------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ----
  **APPENDIX A -                                                                                                                                                                                                      
  SURVIVAL BAR GRAPH**                                                                                                                                                                                                

  **TARGET DOSE: 0                                                                                                                                                                                                    
  MG/M^3^**                                                                                                                                                                                                           

  ANIMAL                          [GD:]{.underline}                                                                                                                                                                   

  [NUMBER]{.underline}            0                   1       2       3       4       5       6       7       8       9       10      11      12      13      14      15      16      17      18      19      20      21

  IGL359F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL360F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL370F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL374F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL395F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL383F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL386F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL394F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL402F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL411F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL422F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL347F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL427F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL400F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL408F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL393F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL419F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL434F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL445F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL446F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL465F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL490F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL406F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL418F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL474F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P
  ---------------------- -------- ------------------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ----

A-1

  ---------------------- -------- ------------------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ----
  **APPENDIX A -                                                                                                                                                                                                      
  SURVIVAL BAR GRAPH**                                                                                                                                                                                                

  **TARGET DOSE: 2000                                                                                                                                                                                                 
  MG/M^3^**                                                                                                                                                                                                           

  ANIMAL                          [GD:]{.underline}                                                                                                                                                                   

  [NUMBER]{.underline}            0                   1       2       3       4       5       6       7       8       9       10      11      12      13      14      15      16      17      18      19      20      21

  IGL346F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL361F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL376F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL381F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL405F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL382F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL390F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL358F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL398F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL350F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL353F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL420F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL435F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =N

  IGL388F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL413F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL455F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =N

  IGL414F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL433F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL441F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL457F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL466F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL475F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL488F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL432F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL477F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P
  ---------------------- -------- ------------------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ----

A-2

  ---------------------- -------- ------------------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ----
  **APPENDIX A -                                                                                                                                                                                                      
  SURVIVAL BAR GRAPH**                                                                                                                                                                                                

  **TARGET DOSE: 10,000                                                                                                                                                                                               
  MG/M^3^**                                                                                                                                                                                                           

  ANIMAL                          [GD:]{.underline}                                                                                                                                                                   

  [NUMBER]{.underline}            0                   1       2       3       4       5       6       7       8       9       10      11      12      13      14      15      16      17      18      19      20      21

  IGL379F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL389F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL391F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL352F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL355F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL417F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL378F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL380F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL348F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL430F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL409F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL421F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL385F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =N

  IGL423F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL440F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL399F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL452F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL436F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL454F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL461F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL469F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL470F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL473F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL407F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P

  IGL442F                \(21\)   **=**               **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   **=**   =P
  ---------------------- -------- ------------------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ----

A-3

  ---------------------- ----------- ------------------- ------- ------- ------- ------- ---------- ------- ------- ------- ------- ------- ------- -- ------- ---------- ------- ------- ------- ------- ------- -- ------- ------- ------- ------- ------- ----
  **APPENDIX A -                                                                                                                                                                                                                                             
  SURVIVAL BAR GRAPH**                                                                                                                                                                                                                                       

  **TARGET DOSE: 20,000                                                                                                                                                                                                                                      
  MG/M^3^**                                                                                                                                                                                                                                                  

  ANIMAL                             [GD:]{.underline}                                                                                                                                                                                                       

  [NUMBER]{.underline}               0                   1       2       3       4                  5       6       7       8       9       10         11                 12      13      14      15      16         17              18      19      20      21

  IGL364F                \(21\)      **=**               **=**   **=**   **=**   **=**              **=**   **=**   **=**   **=**   **=**   **=**      **=**              **=**   **=**   **=**   **=**   **=**      **=**           **=**   **=**   **=**   =P

  IGL367F                \(21\)      **=**               **=**   **=**   **=**   **=**              **=**   **=**   **=**   **=**   **=**   **=**      **=**              **=**   **=**   **=**   **=**   **=**      **=**           **=**   **=**   **=**   =P

  IGL368F                \(21\)      **=**               **=**   **=**   **=**   **=**              **=**   **=**   **=**   **=**   **=**   **=**      **=**              **=**   **=**   **=**   **=**   **=**      **=**           **=**   **=**   **=**   =P

  IGL375F                \(21\)      **=**               **=**   **=**   **=**   **=**              **=**   **=**   **=**   **=**   **=**   **=**      **=**              **=**   **=**   **=**   **=**   **=**      **=**           **=**   **=**   **=**   =P

  IGL363F                \(21\)      **=**               **=**   **=**   **=**   **=**              **=**   **=**   **=**   **=**   **=**   **=**      **=**              **=**   **=**   **=**   **=**   **=**      **=**           **=**   **=**   **=**   =P

  IGL373F                \(21\)      **=**               **=**   **=**   **=**   **=**              **=**   **=**   **=**   **=**   **=**   **=**      **=**              **=**   **=**   **=**   **=**   **=**      **=**           **=**   **=**   **=**   =P

  IGL397F                \(21\)      **=**               **=**   **=**   **=**   **=**              **=**   **=**   **=**   **=**   **=**   **=**      **=**              **=**   **=**   **=**   **=**   **=**      **=**           **=**   **=**   **=**   =P

  IGL357F                \(21\)      **=**               **=**   **=**   **=**   **=**              **=**   **=**   **=**   **=**   **=**   **=**      **=**              **=**   **=**   **=**   **=**   **=**      **=**           **=**   **=**   **=**   =P

  IGL369F                \(21\)      **=**               **=**   **=**   **=**   **=**              **=**   **=**   **=**   **=**   **=**   **=**      **=**              **=**   **=**   **=**   **=**   **=**      **=**           **=**   **=**   **=**   =P

  IGL404F                \(21\)      **=**               **=**   **=**   **=**   **=**              **=**   **=**   **=**   **=**   **=**   **=**      **=**              **=**   **=**   **=**   **=**   **=**      **=**           **=**   **=**   **=**   =P

  IGL365F                \(21\)      **=**               **=**   **=**   **=**   **=**              **=**   **=**   **=**   **=**   **=**   **=**      **=**              **=**   **=**   **=**   **=**   **=**      **=**           **=**   **=**   **=**   =P

  IGL366F                \(21\)      **=**               **=**   **=**   **=**   **=**              **=**   **=**   **=**   **=**   **=**   **=**      **=**              **=**   **=**   **=**   **=**   **=**      **=**           **=**   **=**   **=**   =P

  IGL372F                \(21\)      **=**               **=**   **=**   **=**   **=**              **=**   **=**   **=**   **=**   **=**   **=**      **=**              **=**   **=**   **=**   **=**   **=**      **=**           **=**   **=**   **=**   =P

  IGL396F                \(21\)      **=**               **=**   **=**   **=**   **=**              **=**   **=**   **=**   **=**   **=**   **=**      **=**              **=**   **=**   **=**   **=**   **=**      **=**           **=**   **=**   **=**   =P

  IGL371F                \(21\)      **=**               **=**   **=**   **=**   **=**              **=**   **=**   **=**   **=**   **=**   **=**      **=**              **=**   **=**   **=**   **=**   **=**      **=**           **=**   **=**   **=**   =P

  IGL410F                \(21\)      **=**               **=**   **=**   **=**   **=**              **=**   **=**   **=**   **=**   **=**   **=**      **=**              **=**   **=**   **=**   **=**   **=**      **=**           **=**   **=**   **=**   =P

  IGL415F                \(21\)      **=**               **=**   **=**   **=**   **=**              **=**   **=**   **=**   **=**   **=**   **=**      **=**              **=**   **=**   **=**   **=**   **=**      **=**           **=**   **=**   **=**   =P

  IGL444F                \(21\)      **=**               **=**   **=**   **=**   **=**              **=**   **=**   **=**   **=**   **=**   **=**      **=**              **=**   **=**   **=**   **=**   **=**      **=**           **=**   **=**   **=**   =P

  IGL449F                \(21\)      **=**               **=**   **=**   **=**   **=**              **=**   **=**   **=**   **=**   **=**   **=**      **=**              **=**   **=**   **=**   **=**   **=**      **=**           **=**   **=**   **=**   =P

  IGL451F                \(21\)      **=**               **=**   **=**   **=**   **=**              **=**   **=**   **=**   **=**   **=**   **=**      **=**              **=**   **=**   **=**   **=**   **=**      **=**           **=**   **=**   **=**   =N

  IGL458F                \(21\)      **=**               **=**   **=**   **=**   **=**              **=**   **=**   **=**   **=**   **=**   **=**      **=**              **=**   **=**   **=**   **=**   **=**      **=**           **=**   **=**   **=**   =P

  IGL471F                \(21\)      **=**               **=**   **=**   **=**   **=**              **=**   **=**   **=**   **=**   **=**   **=**      **=**              **=**   **=**   **=**   **=**   **=**      **=**           **=**   **=**   **=**   =P

  IGL424F                \(21\)      **=**               **=**   **=**   **=**   **=**              **=**   **=**   **=**   **=**   **=**   **=**      **=**              **=**   **=**   **=**   **=**   **=**      **=**           **=**   **=**   **=**   =P

  IGL428F                \(21\)      **=**               **=**   **=**   **=**   **=**              **=**   **=**   **=**   **=**   **=**   **=**      **=**              **=**   **=**   **=**   **=**   **=**      **=**           **=**   **=**   **=**   =P

  IGL439F                \(21\)      **=**               **=**   **=**   **=**   **=**              **=**   **=**   **=**   **=**   **=**   **=**      **=**              **=**   **=**   **=**   **=**   **=**      **=**           **=**   **=**   **=**   =P

  NOTE:                  GD -                                                            N - NOT                                                               P -                                                           = - 24                          
                         GESTATION                                                       PREGNANT                                                              PREGNANT                                                      HOURS                           
                         DAY                                                                                                                                                                                                                                 
  ---------------------- ----------- ------------------- ------- ------- ------- ------- ---------- ------- ------- ------- ------- ------- ------- -- ------- ---------- ------- ------- ------- ------- ------- -- ------- ------- ------- ------- ------- ----

A-4

  ---------------- ---- ---- ---- ---- ---- ---- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ----
  **APPENDIX B -                                                                                                                                                         
  GESTATION                                                                                                                                                              
  OBSERVATIONS**                                                                                                                                                         

  **(INCIDENCE OF                                                                                                                                                        
  GESTATION                                                                                                                                                              
  OBSERVATIONS BY                                                                                                                                                        
  TARGET DOSE)**                                                                                                                                                         

                                                                                                                                                                         

  GESTATION                                                                                                                                                              

  DAY              0    1    2    3    4    5    6       7       8       9       10      11      12      13      14      15      16      17      18      19      20      21

                                                                                                                                                                         

  SURVIVORS (A)                                                                                                                                                          

  0 MG/M^3^        25   25   25   25   25   25   25      25      25      25      25      25      25      25      25      25      25      25      25      25      25      25

  2000 MG/M^3^     23   23   23   23   23   23   23      23      23      23      23      23      23      23      23      23      23      23      23      23      23      23

  10,000 MG/M^3^   24   24   24   24   24   24   24      24      24      24      24      24      24      24      24      24      24      24      24      24      24      24

  20,000 MG/M^3^   24   24   24   24   24   24   24      24      24      24      24      24      24      24      24      24      24      24      24      24      24      24

                                                                                                                                                                         

  NO OBSERVABLE                                                                                                                                                          
  ABNORMALITIES                                                                                                                                                          

  0 MG/M^3^        25   25   25   25   25   25   24      24      23      23      23      22      22      22      22      24      23      22      22      22      22      22

  2000 MG/M^3^     23   23   23   23   23   23   23      23      23      23      23      23      23      23      23      23      23      23      23      23      23      23

  10,000 MG/M^3^   24   24   24   24   24   24   24      24      24      24      24      24      24      24      24      24      24      24      24      23      23      23

  20,000 MG/M^3^   24   24   24   24   24   24   24      24      24      24      24      24      24      24      24      24      23      23      23      23      23      23

                                                                                                                                                                         

  ALOPECIA                                                                                                                                                               

  0 MG/M^3^        0    0    0    0    0    0    1       1       2       2       2       3       3       3       3       1       2       3       3       3       3       3

  2000 MG/M^3^     0    0    0    0    0    0    0       0       0       0       0       0       0       0       0       0       0       0       0       0       0       0

  10,000 MG/M^3^   0    0    0    0    0    0    0       0       0       0       0       0       0       0       0       0       0       0       0       1       1       1

  20,000 MG/M^3^   0    0    0    0    0    0    0       0       0       0       0       0       0       0       0       0       1       1       1       1       1       1

                                                                                                                                                                         

  NOTE: (A) -                                                                                                                                                            
  TOTALS DO NOT                                                                                                                                                          
  INCLUDE                                                                                                                                                                
  NON-PREGNANT                                                                                                                                                           
  ANIMALS                                                                                                                                                                
  ---------------- ---- ---- ---- ---- ---- ---- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ----

B-1

  ---------------------- --------------------------- ----- ----- -------------------- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ----
  **APPENDIX B -                                                                                                                                                                               
  GESTATION                                                                                                                                                                                    
  OBSERVATIONS**                                                                                                                                                                               

  **(INDIVIDUAL                                                                                                                                                                                
  GESTATION OBSERVATIONS                                                                                                                                                                       
  BY TARGET DOSE)**                                                                                                                                                                            

  **DOSE: 0 MG/M^3^**                                                                                                                                                                          

  ANIMAL                                                                                                                                                                                       

  [NUMBER]{.underline}   [OBSERVATION]{.underline}               [DAY:]{.underline}   0    1    2    3    4    5    6    7    8    9    10   11   12   13   14   15   16   17   18   19   20   21

  IGL359F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL360F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL370F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL374F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL395F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \-   \-   \-   \-   \-   \-   \-   \+   \-   \-   \-   \-   \-   \-

                         ALOPECIA TRUNK                                               \-   \-   \-   \-   \-   \-   \-   \-   \+   \+   \+   \+   \+   \+   \+   \-   \+   \+   \+   \+   \+   \+

  IGL383F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL386F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL394F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \-   \-   \-   \-   \-   \-   \-   \-   \-   \-   \-   \-   \-   \-   \-   \-

                         ALOPECIA TRUNK                                               \-   \-   \-   \-   \-   \-   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL402F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL411F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL422F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL347F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL427F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

                                                                                                                                                                                               
  ---------------------- --------------------------- ----- ----- -------------------- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ----

B-2

  ---------------------- --------------------------- ----- ----- -------------------- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ----
  **APPENDIX B -                                                                                                                                                                               
  GESTATION                                                                                                                                                                                    
  OBSERVATIONS**                                                                                                                                                                               

  **(INDIVIDUAL                                                                                                                                                                                
  GESTATION OBSERVATIONS                                                                                                                                                                       
  BY TARGET DOSE)**                                                                                                                                                                            

  **DOSE: 0 MG/M^3^                                                                                                                                                                            
  (CONT\'D)**                                                                                                                                                                                  

  ANIMAL                                                                                                                                                                                       

  [NUMBER]{.underline}   [OBSERVATION]{.underline}               [DAY:]{.underline}   0    1    2    3    4    5    6    7    8    9    10   11   12   13   14   15   16   17   18   19   20   21

  IGL400F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL408F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL393F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL419F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL434F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL445F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL446F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL465F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL490F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL406F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL418F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL474F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \-   \-   \-   \-   \+   \+   \-   \-   \-   \-   \-

                         ALOPECIA TRUNK                                               \-   \-   \-   \-   \-   \-   \-   \-   \-   \-   \-   \+   \+   \+   \+   \-   \-   \+   \+   \+   \+   \+
  ---------------------- --------------------------- ----- ----- -------------------- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ----

B-3

  ---------------------- --------------------------- ----- ----- -------------------- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ----
  **APPENDIX B -                                                                                                                                                                               
  GESTATION                                                                                                                                                                                    
  OBSERVATIONS**                                                                                                                                                                               

  **(INDIVIDUAL                                                                                                                                                                                
  GESTATION OBSERVATIONS                                                                                                                                                                       
  BY TARGETE DOSE)**                                                                                                                                                                           

  **DOSE: 2000 MG/M^3^**                                                                                                                                                                       

  ANIMAL                                                                                                                                                                                       

  [NUMBER]{.underline}   [OBSERVATION]{.underline}               [DAY:]{.underline}   0    1    2    3    4    5    6    7    8    9    10   11   12   13   14   15   16   17   18   19   20   21

  IGL346F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL361F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL376F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL381F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL405F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL382F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL390F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL358F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL398F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL350F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL353F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL420F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL435F                                                                                                                                                                                      

                         ANIMAL NOT PREGNANT                                                                                                                                                   
  ---------------------- --------------------------- ----- ----- -------------------- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ----

B-4

  ---------------------- --------------------------- ----- ----- -------------------- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ----
  **APPENDIX B -                                                                                                                                                                                                                                              
  GESTATION                                                                                                                                                                                                                                                   
  OBSERVATIONS**                                                                                                                                                                                                                                              

  **(INDIVIDUAL                                                                                                                                                                                                                                               
  GESTATION OBSERVATIONS                                                                                                                                                                                                                                      
  BY TARGET DOSE)**                                                                                                                                                                                                                                           

  **DOSE: 2000 MG/M^3^                                                                                                                                                                                                                                        
  (CONT\'D)**                                                                                                                                                                                                                                                 

  ANIMAL                                                                                                                                                                                                                                                      

  [NUMBER]{.underline}   [OBSERVATION]{.underline}               [DAY:]{.underline}   0       1       2       3       4       5       6       7       8       9       10      11      12      13      14      15      16      17      18      19      20      21

  IGL388F                                                                                                                                                                                                                                                     

                         NO OBSERVABLE ABNORMALITIES                                  \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+

  IGL413F                                                                                                                                                                                                                                                     

                         NO OBSERVABLE ABNORMALITIES                                  \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+

  IGL455F                                                                                                                                                                                                                                                     

                         ANIMAL NOT PREGNANT                                                                                                                                                                                                                  

  IGL414F                                                                                                                                                                                                                                                     

                         NO OBSERVABLE ABNORMALITIES                                  \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+

  IGL433F                                                                                                                                                                                                                                                     

                         NO OBSERVABLE ABNORMALITIES                                  \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+

  IGL441F                                                                                                                                                                                                                                                     

                         NO OBSERVABLE ABNORMALITIES                                  \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+

  IGL457F                                                                                                                                                                                                                                                     

                         NO OBSERVABLE ABNORMALITIES                                  \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+

  IGL466F                                                                                                                                                                                                                                                     

                         NO OBSERVABLE ABNORMALITIES                                  \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+

  IGL475F                                                                                                                                                                                                                                                     

                         NO OBSERVABLE ABNORMALITIES                                  \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+

  IGL488F                                                                                                                                                                                                                                                     

                         NO OBSERVABLE ABNORMALITIES                                  \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+

  IGL432F                                                                                                                                                                                                                                                     

                         NO OBSERVABLE ABNORMALITIES                                  \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+

  IGL477F                                                                                                                                                                                                                                                     

                         NO OBSERVABLE ABNORMALITIES                                  \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+
  ---------------------- --------------------------- ----- ----- -------------------- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ----

B-5

  ---------------------- --------------------------- ----- ----- -------------------- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ----
  **APPENDIX B -                                                                                                                                                                                                                                              
  GESTATION                                                                                                                                                                                                                                                   
  OBSERVATIONS**                                                                                                                                                                                                                                              

  **(INDIVIDUAL                                                                                                                                                                                                                                               
  GESTATION OBSERVATIONS                                                                                                                                                                                                                                      
  BY TARGET DOSE)**                                                                                                                                                                                                                                           

  **DOSE: 10,000                                                                                                                                                                                                                                              
  MG/M^3^**                                                                                                                                                                                                                                                   

  ANIMAL                                                                                                                                                                                                                                                      

  [NUMBER]{.underline}   [OBSERVATION]{.underline}               [DAY:]{.underline}   0       1       2       3       4       5       6       7       8       9       10      11      12      13      14      15      16      17      18      19      20      21

  IGL379F                                                                                                                                                                                                                                                     

                         NO OBSERVABLE ABNORMALITIES                                  \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+

  IGL389F                                                                                                                                                                                                                                                     

                         NO OBSERVABLE ABNORMALITIES                                  \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+

  IGL391F                                                                                                                                                                                                                                                     

                         NO OBSERVABLE ABNORMALITIES                                  \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+

  IGL352F                                                                                                                                                                                                                                                     

                         NO OBSERVABLE ABNORMALITIES                                  \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+

  IGL355F                                                                                                                                                                                                                                                     

                         NO OBSERVABLE ABNORMALITIES                                  \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+

  IGL417F                                                                                                                                                                                                                                                     

                         NO OBSERVABLE ABNORMALITIES                                  \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+

  IGL378F                                                                                                                                                                                                                                                     

                         NO OBSERVABLE ABNORMALITIES                                  \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+

  IGL380F                                                                                                                                                                                                                                                     

                         NO OBSERVABLE ABNORMALITIES                                  \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+

  IGL348F                                                                                                                                                                                                                                                     

                         NO OBSERVABLE ABNORMALITIES                                  \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+

  IGL430F                                                                                                                                                                                                                                                     

                         NO OBSERVABLE ABNORMALITIES                                  \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+

  IGL409F                                                                                                                                                                                                                                                     

                         NO OBSERVABLE ABNORMALITIES                                  \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+

  IGL421F                                                                                                                                                                                                                                                     

                         NO OBSERVABLE ABNORMALITIES                                  \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+

  IGL385F                                                                                                                                                                                                                                                     

                         ANIMAL NOT PREGNANT                                                                                                                                                                                                                  
  ---------------------- --------------------------- ----- ----- -------------------- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ----

B-6

  ---------------------- --------------------------- ----- ----- -------------------- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ----
  **APPENDIX B -                                                                                                                                                                                                                                              
  GESTATION                                                                                                                                                                                                                                                   
  OBSERVATIONS**                                                                                                                                                                                                                                              

  **(INDIVIDUAL                                                                                                                                                                                                                                               
  GESTATION OBSERVATIONS                                                                                                                                                                                                                                      
  BY TARGET DOSE)**                                                                                                                                                                                                                                           

  **DOSE: 10,000 MG/M^3^                                                                                                                                                                                                                                      
  (CONT\'D)**                                                                                                                                                                                                                                                 

                                                                                                                                                                                                                                                              

  ANIMAL                                                                                                                                                                                                                                                      

  [NUMBER]{.underline}   [OBSERVATION]{.underline}               [DAY:]{.underline}   0       1       2       3       4       5       6       7       8       9       10      11      12      13      14      15      16      17      18      19      20      21

  IGL423F                                                                                                                                                                                                                                                     

                         NO OBSERVABLE ABNORMALITIES                                  \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+

  IGL440F                                                                                                                                                                                                                                                     

                         NO OBSERVABLE ABNORMALITIES                                  \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+

  IGL399F                                                                                                                                                                                                                                                     

                         NO OBSERVABLE ABNORMALITIES                                  \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+

  IGL452F                                                                                                                                                                                                                                                     

                         NO OBSERVABLE ABNORMALITIES                                  \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+

  IGL436F                                                                                                                                                                                                                                                     

                         NO OBSERVABLE ABNORMALITIES                                  \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+

  IGL454F                                                                                                                                                                                                                                                     

                         NO OBSERVABLE ABNORMALITIES                                  \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+

  IGL461F                                                                                                                                                                                                                                                     

                         NO OBSERVABLE ABNORMALITIES                                  \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+

  IGL469F                                                                                                                                                                                                                                                     

                         NO OBSERVABLE ABNORMALITIES                                  \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+

  IGL470F                                                                                                                                                                                                                                                     

                         NO OBSERVABLE ABNORMALITIES                                  \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+

  IGL473F                                                                                                                                                                                                                                                     

                         NO OBSERVABLE ABNORMALITIES                                  \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+

  IGL407F                                                                                                                                                                                                                                                     

                         NO OBSERVABLE ABNORMALITIES                                  \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \-      \-      \-

                         ALOPECIA EXTREMITIES                                         \-      \-      \-      \-      \-      \-      \-      \-      \-      \-      \-      \-      \-      \-      \-      \-      \-      \-      \-      \+      \+      \+

  IGL442F                                                                                                                                                                                                                                                     

                         NO OBSERVABLE ABNORMALITIES                                  \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+      \+
  ---------------------- --------------------------- ----- ----- -------------------- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ---- -- ----

B-7

  ---------------------- --------------------------- ----- ----- -------------------- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ----
  **APPENDIX B -                                                                                                                                                                               
  GESTATION                                                                                                                                                                                    
  OBSERVATIONS**                                                                                                                                                                               

  **(INDIVIDUAL                                                                                                                                                                                
  GESTATION OBSERVATIONS                                                                                                                                                                       
  BY TARGET DOSE)**                                                                                                                                                                            

  **DOSE: 20,000                                                                                                                                                                               
  MG/M^3^**                                                                                                                                                                                    

  ANIMAL                                                                                                                                                                                       

  [NUMBER]{.underline}   [OBSERVATION]{.underline}               [DAY:]{.underline}   0    1    2    3    4    5    6    7    8    9    10   11   12   13   14   15   16   17   18   19   20   21

  IGL364F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL367F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL368F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL375F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL363F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL373F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL397F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL357F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL369F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL404F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL365F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL366F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL372F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+
  ---------------------- --------------------------- ----- ----- -------------------- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ----

B-8

  ---------------------- --------------------------- ----- ----- -------------------- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ----
  **APPENDIX B -                                                                                                                                                                               
  GESTATION                                                                                                                                                                                    
  OBSERVATIONS**                                                                                                                                                                               

  **(INDIVIDUAL                                                                                                                                                                                
  GESTATION OBSERVATIONS                                                                                                                                                                       
  BY TARGET DOSE)**                                                                                                                                                                            

  **DOSE: 20,000 MG/M^3^                                                                                                                                                                       
  (CONT\'D)**                                                                                                                                                                                  

  ANIMAL                                                                                                                                                                                       

  [NUMBER]{.underline}   [OBSERVATION]{.underline}               [DAY:]{.underline}   0    1    2    3    4    5    6    7    8    9    10   11   12   13   14   15   16   17   18   19   20   21

  IGL396F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL371F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL410F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL415F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL444F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL449F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL451F                                                                                                                                                                                      

                         ANIMAL NOT PREGNANT                                                                                                                                                   

  IGL458F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL471F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL424F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL428F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+

  IGL439F                                                                                                                                                                                      

                         NO OBSERVABLE ABNORMALITIES                                  \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \+   \-   \-   \-   \-   \-   \-

                         ALOPECIA TRUNK                                               \-   \-   \-   \-   \-   \-   \-   \-   \-   \-   \-   \-   \-   \-   \-   \-   \+   \+   \+   \+   \+   \+
  ---------------------- --------------------------- ----- ----- -------------------- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ----

B-9

  --------------- ---------------- ---------------- ---------------- ----------------- ----------------- ----------------- ----------------- ----------------- ---------------------- ------------------
  **APPENDIX C -                                                                                                                                                                      
  GESTATION BODY                                                                                                                                                                      
  WEIGHT AND BODY                                                                                                                                                                     
  WEIGHT CHANGE**                                                                                                                                                                     

  **(MEAN                                                                                                                                                                             
  GESTATION BODY                                                                                                                                                                      
  WEIGHT AND BODY                                                                                                                                                                     
  WEIGHT CHANGE                                                                                                                                                                       
  BY TARGET                                                                                                                                                                           
  DOSE)**                                                                                                                                                                             

  **(SEE LIST OF                                                                                                                                                                      
  ABBREVIATIONS                                                                                                                                                                       
  FOR STATISTICAL                                                                                                                                                                     
  SYMBOLS ON                                                                                                                                                                          
  PAGES 5-1 AND                                                                                                                                                                       
  5-2)**                                                                                                                                                                              

  **(GRAMS)**                                                                                                                                                                         

                                                                                                                                                                                      

                  [GD              [GD              [GD              [GD               [GD               [GD               [GD               [GD               [UTERUS]{.underline}   [GD
                  0]{.underline}   5]{.underline}   8]{.underline}   11]{.underline}   14]{.underline}   17]{.underline}   20]{.underline}   21]{.underline}                          21C]{.underline}

  FEMALE          A-L-             A-L-             A-L-             A-L-              A-L               A-L-              A-L-              A-L-              A-L-                   A-L-

  0 MG/M^3^                                                                                                                                                                           

  MEAN            270              299.2            305.4            317.2             330.6             358.8             404.2             420.9             104.8                  315.5

  STD.DEV.        14.6             16.7             18.1             19.3              21.4              27.1              33.1              35.7              21.9                   20.8

  \(N\)           25               25               25               25                25                25                25                2                 25                     24

                                                                                                                                                                                      

  2000 MG/M^3^                                                                                                                                                                        

  MEAN            267              292.3            300              311.8             324.5             354.6             403.8             421.7             106.4                  315.2

  STD.DEV.        13.7             19.6             19.1             19.3              21.5              23.7              28.1              30                22.1                   22.9

  \(N\)           23               23               23               23                23                23                23                23                23                     23

                                                                                                                                                                                      

  10,000 MG/M^3^                                                                                                                                                                      

  MEAN            270.2            299.1            302.8            312.7             325               352               398.8             418.7             100                    318.7

  STD.DEV.        13.1             14.8             14.5             16.2              17.6              23.4              32.5              32.8              26.8                   16.7

  \(N\)           24               24               24               24                24                24                24                24                24                     24

                                                                                                                                                                                      

  20,000 MG/M^3^                                                                                                                                                                      

  MEAN            269.9            295.5            298.9            307.3             317.6             347.5             394.8             413.5             104.8                  308.8

  STD.DEV.        13.7             19.1             18.5             19.1              19.3              20.8              22.9              26.9              14.9                   20.7

  \(N\)           24               24               24               24                24                24                24                24                24                     24

                                                                                                                                                                                      

                                                                                                                                                                                      
  --------------- ---------------- ---------------- ---------------- ----------------- ----------------- ----------------- ----------------- ----------------- ---------------------- ------------------

C-1

  --------------- ------------------ ------------------ ------------------- -------------------- -------------------- -------------------- -------------------- ------------------- ------------------- --------------------
  **APPENDIX C -                                                                                                                                                                                        
  GESTATION BODY                                                                                                                                                                                        
  WEIGHT AND BODY                                                                                                                                                                                       
  WEIGHT CHANGE**                                                                                                                                                                                       

  **(MEAN                                                                                                                                                                                               
  GESTATION BODY                                                                                                                                                                                        
  WEIGHT AND BODY                                                                                                                                                                                       
  WEIGHT CHANGE                                                                                                                                                                                         
  BY TARGET                                                                                                                                                                                             
  DOSE)**                                                                                                                                                                                               

  **(SEE LIST OF                                                                                                                                                                                        
  ABBREVIATIONS                                                                                                                                                                                         
  FOR STATISTICAL                                                                                                                                                                                       
  SYMBOLS ON                                                                                                                                                                                            
  PAGES 5-1 AND                                                                                                                                                                                         
  5-2)**                                                                                                                                                                                                

  **(GRAMS)**                                                                                                                                                                                           

                                                                                                                                                                                                        

                  [GD                [GD                [GD                 [GD                  [GD                  [GD                  [GD                  [GD                 [GD                 [GD
                  0-5]{.underline}   5-8]{.underline}   8-11]{.underline}   11-14]{.underline}   14-17]{.underline}   17-20]{.underline}   20-21]{.underline}   5-21]{.underline}   0-21]{.underline}   0-21C]{.underline}

  FEMALE          A-L-               A-L                AL+                 A-L                  A-L-                 K-J-                 K-J-                 A-L-                A-L-                A-L

  0 MG/M^3^                                                                                                                                                                                             

  MEAN            29.2               6.2                11.8                13.4                 28.2                 45.4                 17.4                 104.5               151.3               46.0

  STD.DEV.        6.5                5.2                4.6                 4.7                  9                    10                   9.5                  91.0                24.9                11.7

  \(N\)           25                 25                 25                  25                   25                   25                   24                   25                  24                  24

                                                                                                                                                                                                        

  2000 MG/M^3^                                                                                                                                                                                          

  MEAN            25.3               7.7                11.8                12.7                 30.1                 49.2                 17.9                 129.3               154.7               48.2

  STD.DEV.        9.9                5.9                4.4                 4.5                  8.2                  8.6                  6.4                  23.6                23.3                15.2

  \(N\)           23                 23                 23                  23                   23                   23                   23                   23                  23                  23

                                                                                                                                                                                                        

  10,000 MG/M^3^                                                                                                                                                                                        

  MEAN            28.9               3.7                10                  12.3                 27.1                 46.8                 19.9                 119.6               148.5               48.5

  STD.DEV.        7.3                6.2                5.8                 4                    8.1                  13.1                 5.3                  25                  28.5                13.3

  \(N\)           24                 24                 24                  24                   24                   24                   24                   24                  24                  24

                                                                                                                                                                                                        

  20,000 MG/M^3^                                        \*                                                                                                                                              

  MEAN            25.6               3.4                8.4                 10.4                 29.9                 47.3                 18.8                 118                 143.6               38.9

  STD.DEV.        9.9                7.7                3.4                 3.8                  6.4                  6.2                  5.8                  17.1                18.8                13.9

  \(N\)           24                 24                 24                  24                   24                   24                   24                   24                  24                  24

  NOTE: GD -                                                                                                                                                                                            
  GESTATION DAY                                                                                                                                                                                         

  21C (DAY 21                                                                                                                                                                                           
  CORRECTED) =                                                                                                                                                                                          
  DAY 21 BODY                                                                                                                                                                                           
  WEIGHT -                                                                                                                                                                                              
  UTERINE WEIGHT                                                                                                                                                                                        
  --------------- ------------------ ------------------ ------------------- -------------------- -------------------- -------------------- -------------------- ------------------- ------------------- --------------------

C-2

  ---------------------- ----------------- ----------------- ----------------- ------------------ ------------------ ------------------ ------------------ ------------------ ------------------- ----------------------
  **APPENDIX C -                                                                                                                                                                                  
  GESTATION BODY WEIGHT                                                                                                                                                                           
  AND BODY WEIGHT                                                                                                                                                                                 
  CHANGE**                                                                                                                                                                                        

  **(INDIVIDUAL                                                                                                                                                                                   
  GESTATION BODY WEIGHT                                                                                                                                                                           
  BY TARGET DOSE)**                                                                                                                                                                               

  **(GRAMS)**                                                                                                                                                                                     

  **DOSE: 0 MG/M^3^**                                                                                                                                                                             

  ANIMAL                 GD                GD                GD                GD                 GD                 GD                 GD                 GD                 GD                  UTERINE

  [NUMBER]{.underline}   [0]{.underline}   [5]{.underline}   [8]{.underline}   [11]{.underline}   [14]{.underline}   [17]{.underline}   [20]{.underline}   [21]{.underline}   [21C]{.underline}   [WEIGHT]{.underline}

  IGL359F                257               280               283               282                294                328                372                406                307                 99

  IGL360F                270               297               297               308                323                351                401                417                309                 108

  IGL370F                268               308               312               327                343                373                396                403                289                 114

  IGL374F                258               282               280               293                303                320                364                380                281                 99

  IGL395F                277               303               306               318                337                370                422                445                320                 125

  IGL383F                271               293               301               315                333                371                415                444                325                 119

  IGL386F                249               274               285               298                312                337                391                403                297                 106

  IGL394F                267               296               299               317                334                369                409                431                311                 120

  IGL402F                274               308               309               323                336                374                431                460                331                 129

  IGL411F                269               300               307               322                337                373                408                427                327                 100

  IGL422F                269               295               306               314                331                366                421                425                312                 113

  IGL347F                290               321               332               343                359                384                434                448                343                 105

  IGL427F                241               276               283               292                296                295                316                309                294                 15

  IGL400F                275               303               313               329                350                392                450                460                330                 130

  IGL408F                291               313               335               346                360                400                450                474                364                 110

  IGL393F                250               281               288               294                305                325                367                393                301                 92

  IGL419F                258               280               290               295                310                331                380                398                291                 107

  IGL434F                299               326               338               344                366                395                457                476                349                 127

  IGL445F                253               285               284               300                311                335                381                402                298                 104

  IGL446F                271               294               298               309                313                340                379                405                304                 101

  IGL465F                291               341               344               355                366                397                452                454                343                 111

  IGL490F                280               314               316               337                352                377                421                B                  398                 92

  IGL406F                288               316               321               335                341                363                411                422                325                 97

  IGL418F                263               298               307               320                332                355                389                409                316                 93

  IGL474F                271               295               301               315                322                350                389                411                306                 105
  ---------------------- ----------------- ----------------- ----------------- ------------------ ------------------ ------------------ ------------------ ------------------ ------------------- ----------------------

C-3

  ---------------------- ----------------- ----------------- ----------------- ------------------ ------------------ ------------------ ------------------ ------------------ ------------------- ----------------------
  **APPENDIX C -                                                                                                                                                                                  
  GESTATION BODY WEIGHT                                                                                                                                                                           
  AND BODY WEIGHT                                                                                                                                                                                 
  CHANGE**                                                                                                                                                                                        

  **(INDIVIDUAL                                                                                                                                                                                   
  GESTATION BODY WEIGHT                                                                                                                                                                           
  BY TARGET DOSE)**                                                                                                                                                                               

  **(GRAMS)**                                                                                                                                                                                     

  **DOSE: 2000 MG/M^3^**                                                                                                                                                                          

  ANIMAL                 GD                GD                GD                GD                 GD                 GD                 GD                 GD                 GD                  UTERINE

  [NUMBER]{.underline}   [0]{.underline}   [5]{.underline}   [8]{.underline}   [11]{.underline}   [14]{.underline}   [17]{.underline}   [20]{.underline}   [21]{.underline}   [21C]{.underline}   [WEIGHT]{.underline}

  IGL346F                276               300               313               326                338                359                406                427                323                 104

  IGL361F                265               296               300               308                325                351                407                421                309                 112

  IGL376F                258               266               269               281                296                331                375                390                290                 100

  IGL381F                261               287               284               295                304                321                366                380                294                 86

  IGL405F                255               288               289               298                317                352                403                430                307                 123

  IGL382F                267               293               304               318                333                367                423                444                324                 120

  IGL390F                253               282               293               301                307                337                378                397                297                 100

  IGL358F                273               296               300               314                328                366                423                432                300                 132

  IGL398F                243               259               283               292                304                344                398                410                289                 121

  IGL350F                270               279               288               309                320                352                403                426                308                 118

  IGL353F                292               331               333               347                369                413                472                494                365                 129

  IGL420F                261               296               308               323                342                366                419                431                333                 98

  IGL435F NP                                                                                                                                                                                      

  IGL388F                283               318               322               334                347                373                421                438                334                 104

  IGL413F                261               278               290               294                303                337                382                396                292                 104

  IGL455F NP                                                                                                                                                                                      

  IGL414F                270               282               298               305                316                348                393                409                301                 108

  IGL433F                261               288               291               314                321                353                412                437                320                 117

  IGL441F                287               312               320               325                343                372                411                428                317                 111

  IGL457F                264               279               281               293                298                316                360                388                305                 83

  IGL466F                272               298               307               320                330                367                426                447                327                 120

  IGL475F                291               341               349               358                370                385                415                419                376                 43

  IGL488F                240               271               274               288                295                316                348                358                298                 60

  IGL432F                280               304               315               329                344                388                449                477                339                 138

  IGL477F                258               279               290               300                313                341                397                419                302                 117
  ---------------------- ----------------- ----------------- ----------------- ------------------ ------------------ ------------------ ------------------ ------------------ ------------------- ----------------------

C-4

  ---------------------- ----------------- ----------------- ----------------- ------------------ ------------------ ------------------ ------------------ ------------------ ------------------- ----------------------
  **APPENDIX C -                                                                                                                                                                                  
  GESTATION BODY WEIGHT                                                                                                                                                                           
  AND BODY WEIGHT                                                                                                                                                                                 
  CHANGE**                                                                                                                                                                                        

  **(INDIVIDUAL                                                                                                                                                                                   
  GESTATION BODY WEIGHT                                                                                                                                                                           
  BY TARGET DOSE)**                                                                                                                                                                               

  **(GRAMS)**                                                                                                                                                                                     

  **DOSE: 10,000                                                                                                                                                                                  
  MG/M^3^**                                                                                                                                                                                       

  ANIMAL                 GD                GD                GD                GD                 GD                 GD                 GD                 GD                 GD                  UTERINE

  [NUMBER]{.underline}   [0]{.underline}   [5]{.underline}   [8]{.underline}   [11]{.underline}   [14]{.underline}   [17]{.underline}   [20]{.underline}   [21]{.underline}   [21C]{.underline}   [WEIGHT]{.underline}

  IGL379F                275               300               299               311                331                365                421                443                320                 123

  IGL389F                277               306               301               332                346                382                439                461                330                 131

  IGL391F                279               312               308               321                328                364                416                438                337                 101

  IGL352F                249               284               288               294                302                324                370                390                282                 108

  IGL355F                255               299               299               307                314                345                400                421                304                 117

  IGL417F                275               316               319               325                347                374                431                457                336                 121

  IGL378F                278               303               315               319                332                360                400                415                321                 94

  IGL380F                250               275               286               296                308                336                390                409                304                 105

  IGL348F                275               299               297               308                318                341                391                407                307                 100

  IGL430F                260               282               289               292                302                314                333                344                309                 35

  IGL409F                291               327               331               340                350                380                418                437                335                 102

  IGL421F                255               277               286               295                307                330                374                392                298                 94

  IGL385F NP                                                                                                                                                                                      

  IGL423F                266               308               318               327                344                380                435                452                327                 125

  IGL440F                262               287               296               307                322                349                381                402                332                 70

  IGL399F                254               276               286               292                306                332                395                414                293                 121

  IGL452F                274               306               312               318                329                348                395                420                319                 101

  IGL436F                298               320               325               339                351                373                426                447                340                 107

  IGL454F                258               293               302               311                326                352                393                428                347                 81

  IGL461F                276               304               301               320                328                349                384                402                315                 87

  IGL469F                266               285               281               284                291                296                308                332                311                 21

  IGL470F                287               323               332               342                356                398                454                463                342                 121

  IGL473F                284               306               294               303                320                355                412                425                308                 117

  IGL407F                275               297               303               312                322                352                417                442                322                 120

  IGL442F                266               293               298               310                319                350                388                408                310                 98
  ---------------------- ----------------- ----------------- ----------------- ------------------ ------------------ ------------------ ------------------ ------------------ ------------------- ----------------------

C-5

  ---------------------- ----------------- ----------------- ----------------- ------------------ ------------------ ------------------ ------------------ ------------------ ------------------- ----------------------
  **APPENDIX C -                                                                                                                                                                                  
  GESTATION BODY WEIGHT                                                                                                                                                                           
  AND BODY WEIGHT                                                                                                                                                                                 
  CHANGE**                                                                                                                                                                                        

  **(INDIVIDUAL                                                                                                                                                                                   
  GESTATION BODY WEIGHT                                                                                                                                                                           
  BY TARGET DOSE)**                                                                                                                                                                               

  **(GRAMS)**                                                                                                                                                                                     

  **DOSE: 20,000                                                                                                                                                                                  
  MG/M^3^**                                                                                                                                                                                       

  ANIMAL                 GD                GD                GD                GD                 GD                 GD                 GD                 GD                 GD                  UTERINE

  [NUMBER]{.underline}   [0]{.underline}   [5]{.underline}   [8]{.underline}   [11]{.underline}   [14]{.underline}   [17]{.underline}   [20]{.underline}   [21]{.underline}   [21C]{.underline}   [WEIGHT]{.underline}

  IGL364F                271               291               291               298                311                337                394                410                287                 123

  IGL367F                257               303               298               309                323                356                406                420                314                 106

  IGL368F                287               314               317               330                341                373                415                435                325                 110

  IGL375F                269               300               293               303                312                337                384                405                320                 85

  IGL363F                257               274               283               292                299                319                348                357                305                 52

  IGL373F                260               280               273               280                287                316                359                375                282                 93

  IGL397F                280               302               298               306                315                345                396                417                299                 118

  IGL357F                267               302               296               308                321                344                386                402                305                 97

  IGL369F                254               284               285               298                309                336                382                399                298                 101

  IGL404F                251               279               283               292                302                331                382                398                294                 104

  IGL365F                255               269               275               277                290                320                373                388                278                 110

  IGL366F                271               289               296               300                311                345                389                410                298                 112

  IGL372F                287               312               315               318                332                370                419                435                325                 110

  IGL396F                274               278               290               301                319                360                406                423                316                 107

  IGL371F                277               303               301               309                318                346                395                422                315                 107

  IGL410F                256               285               292               294                307                335                391                405                300                 105

  IGL415F                264               281               307               312                325                360                408                431                307                 124

  IGL444F                293               331               329               339                354                375                421                444                339                 105

  IGL449F                283               306               320               326                339                371                426                445                332                 113

  IGL451F NP                                                                                                                                                                                      

  IGL458F                256               278               279               290                297                335                388                402                293                 109

  IGL471F                267               282               283               295                301                322                360                378                293                 85

  IGL424F                284               320               329               341                348                391                438                477                364                 113

  IGL428F                299               345               345               354                357                378                428                451                336                 115

  IGL439F                259               284               295               302                305                339                381                396                286                 110
  ---------------------- ----------------- ----------------- ----------------- ------------------ ------------------ ------------------ ------------------ ------------------ ------------------- ----------------------

C-6

  ---------------------- ------------------- ------------------- -------------------- --------------------- --------------------- --------------------- --------------------- -------------------- -------------------- ---------------------
  **APPENDIX C -                                                                                                                                                                                                        
  GESTATION BODY WEIGHT                                                                                                                                                                                                 
  AND BODY WEIGHT                                                                                                                                                                                                       
  CHANGE**                                                                                                                                                                                                              

  **(INDIVIDUAL                                                                                                                                                                                                         
  GESTATION BODY WEIGHT                                                                                                                                                                                                 
  CHANGE BY TARGET                                                                                                                                                                                                      
  DOSE)**                                                                                                                                                                                                               

  **(GRAMS)**                                                                                                                                                                                                           

  **DOSE: 0 MG/M^3^**                                                                                                                                                                                                   

  ANIMAL                 GD                  GD                  GD                   GD                    GD                    GD                    GD                    GD                   GD                   GD

  [NUMBER]{.underline}   [0-5]{.underline}   [5-8]{.underline}   [8-11]{.underline}   [11-14]{.underline}   [14-17]{.underline}   [17-20]{.underline}   [20-21]{.underline}   [5-21]{.underline}   [0-21]{.underline}   [0-21C]{.underline}

  IGL359F                23                  3                   -1                   12                    34                    44                    34                    126                  149                  50

  IGL360F                27                  0                   11                   15                    28                    50                    16                    120                  147                  39

  IGL370F                40                  4                   15                   16                    30                    23                    7                     95                   135                  21

  IGL374F                24                  -2                  13                   10                    17                    44                    16                    98                   122                  23

  IGL395F                26                  3                   12                   19                    33                    52                    23                    142                  168                  43

  IGL383F                22                  8                   14                   18                    38                    44                    29                    151                  173                  54

  IGL386F                25                  11                  13                   14                    25                    54                    12                    129                  154                  48

  IGL394F                29                  3                   18                   17                    35                    40                    22                    135                  164                  44

  IGL402F                34                  1                   14                   13                    38                    57                    29                    152                  186                  57

  IGL411F                31                  7                   15                   15                    36                    35                    19                    127                  158                  58

  IGL422F                26                  11                  8                    17                    35                    55                    4                     130                  156                  43

  IGL347F                31                  11                  11                   16                    25                    50                    14                    127                  158                  53

  IGL427F                35                  7                   9                    4                     -1                    21                    -7                    33                   68                   53

  IGL400F                28                  10                  16                   21                    42                    58                    10                    157                  185                  55

  IGL408F                22                  22                  11                   14                    40                    50                    24                    161                  183                  73

  IGL393F                31                  7                   6                    11                    20                    42                    26                    112                  143                  51

  IGL419F                22                  10                  5                    15                    21                    49                    18                    118                  140                  33

  IGL434F                27                  12                  6                    22                    29                    62                    19                    150                  177                  50

  IGL445F                32                  -1                  16                   11                    24                    46                    21                    117                  149                  45

  IGL446F                23                  4                   11                   4                     27                    39                    26                    111                  134                  33

  IGL465F                50                  3                   11                   11                    31                    55                    2                     113                  163                  52

  IGL490F                34                  2                   21                   15                    25                    44                    C                     C                    C                    C

  IGL406F                28                  5                   14                   6                     22                    48                    11                    106                  134                  37

  IGL418F                35                  9                   13                   12                    23                    34                    20                    111                  146                  53

  IGL474F                24                  6                   14                   7                     28                    39                    22                    116                  140                  35
  ---------------------- ------------------- ------------------- -------------------- --------------------- --------------------- --------------------- --------------------- -------------------- -------------------- ---------------------

C-7

  ---------------------- ------------------- ------------------- -------------------- --------------------- --------------------- --------------------- --------------------- -------------------- -------------------- ---------------------
  **APPENDIX C -                                                                                                                                                                                                        
  GESTATION BODY WEIGHT                                                                                                                                                                                                 
  AND BODY WEIGHT                                                                                                                                                                                                       
  CHANGE**                                                                                                                                                                                                              

  **(INDIVIDUAL                                                                                                                                                                                                         
  GESTATION BODY WEIGHT                                                                                                                                                                                                 
  CHANGE BY TARGET                                                                                                                                                                                                      
  DOSE)**                                                                                                                                                                                                               

  **(GRAMS)**                                                                                                                                                                                                           

  **DOSE: 2000 MG/M^3^**                                                                                                                                                                                                

  ANIMAL                 GD                  GD                  GD                   GD                    GD                    GD                    GD                    GD                   GD                   GD

  [NUMBER]{.underline}   [0-5]{.underline}   [5-8]{.underline}   [8-11]{.underline}   [11-14]{.underline}   [14-17]{.underline}   [17-20]{.underline}   [20-21]{.underline}   [5-21]{.underline}   [0-21]{.underline}   [0-21C]{.underline}

  IGL346F                24                  13                  13                   12                    21                    47                    21                    127                  151                  47

  IGL361F                31                  4                   8                    17                    26                    56                    14                    125                  156                  44

  IGL376F                8                   3                   12                   15                    35                    44                    15                    124                  132                  32

  IGL381F                26                  -3                  11                   9                     17                    45                    14                    93                   119                  33

  IGL405F                33                  1                   9                    19                    35                    51                    27                    142                  175                  52

  IGL382F                26                  11                  14                   15                    34                    56                    21                    151                  177                  57

  IGL390F                29                  11                  8                    6                     30                    41                    19                    115                  144                  44

  IGL358F                23                  4                   14                   14                    38                    57                    9                     136                  159                  27

  IGL398F                16                  24                  9                    12                    40                    54                    12                    151                  167                  46

  IGL350F                9                   9                   21                   11                    32                    51                    23                    147                  156                  38

  IGL353F                39                  2                   14                   22                    44                    59                    22                    163                  202                  73

  IGL420F                35                  12                  15                   19                    24                    53                    12                    135                  170                  72

  IGL435F NP                                                                                                                                                                                                            

  IGL388F                35                  4                   12                   13                    26                    48                    17                    120                  155                  51

  IGL413F                17                  12                  4                    9                     34                    45                    14                    118                  135                  31

  IGL455F NP                                                                                                                                                                                                            

  IGL414F                12                  16                  7                    11                    32                    45                    16                    127                  139                  31

  IGL433F                27                  3                   23                   7                     32                    59                    25                    149                  176                  59

  IGL441F                25                  8                   5                    18                    29                    39                    17                    116                  141                  30

  IGL457F                15                  2                   12                   5                     18                    44                    28                    109                  124                  41

  IGL466F                26                  9                   13                   10                    37                    59                    21                    149                  175                  55

  IGL475F                50                  8                   9                    12                    15                    30                    4                     78                   128                  85

  IGL488F                31                  3                   14                   7                     21                    32                    10                    87                   118                  58

  IGL432F                24                  11                  14                   15                    44                    61                    28                    173                  197                  59

  IGL477F                21                  11                  10                   13                    28                    56                    22                    140                  161                  44
  ---------------------- ------------------- ------------------- -------------------- --------------------- --------------------- --------------------- --------------------- -------------------- -------------------- ---------------------

C-8

  ---------------------- ------------------- ------------------- -------------------- --------------------- --------------------- --------------------- --------------------- -------------------- -------------------- ---------------------
  **APPENDIX C -                                                                                                                                                                                                        
  GESTATION BODY WEIGHT                                                                                                                                                                                                 
  AND BODY WEIGHT                                                                                                                                                                                                       
  CHANGE**                                                                                                                                                                                                              

  **(INDIVIDUAL                                                                                                                                                                                                         
  GESTATION BODY WEIGHT                                                                                                                                                                                                 
  CHANGE BY TARGET                                                                                                                                                                                                      
  DOSE)**                                                                                                                                                                                                               

  **(GRAMS)**                                                                                                                                                                                                           

  **DOSE: 10,000                                                                                                                                                                                                        
  MG/M^3^**                                                                                                                                                                                                             

  ANIMAL                 GD                  GD                  GD                   GD                    GD                    GD                    GD                    GD                   GD                   GD

  [NUMBER]{.underline}   [0-5]{.underline}   [5-8]{.underline}   [8-11]{.underline}   [11-14]{.underline}   [14-17]{.underline}   [17-20]{.underline}   [20-21]{.underline}   [5-21]{.underline}   [0-21]{.underline}   [0-21C]{.underline}

  IGL379F                25                  -1                  12                   20                    34                    56                    22                    143                  168                  45

  IGL389F                29                  -5                  31                   14                    36                    57                    22                    155                  184                  53

  IGL391F                33                  -4                  13                   7                     36                    52                    22                    126                  159                  58

  IGL352F                35                  4                   6                    8                     22                    46                    20                    106                  141                  33

  IGL355F                44                  0                   8                    7                     31                    55                    21                    122                  166                  49

  IGL417F                41                  3                   6                    22                    27                    57                    26                    141                  182                  61

  IGL378F                25                  12                  4                    13                    28                    40                    15                    112                  137                  43

  IGL380F                25                  11                  10                   12                    28                    54                    19                    134                  159                  54

  IGL348F                24                  -2                  11                   10                    23                    50                    16                    108                  132                  32

  IGL430F                22                  7                   3                    10                    12                    19                    11                    62                   84                   49

  IGL409F                36                  4                   9                    10                    30                    38                    19                    110                  146                  44

  IGL421F                22                  9                   9                    12                    23                    44                    18                    115                  137                  43

  IGL385F NP                                                                                                                                                                                                            

  IGL423F                42                  10                  9                    17                    36                    55                    17                    144                  186                  61

  IGL440F                25                  9                   11                   15                    27                    32                    21                    115                  140                  70

  IGL399F                22                  10                  6                    14                    26                    63                    19                    138                  160                  39

  IGL452F                32                  6                   6                    11                    19                    47                    25                    114                  146                  45

  IGL436F                22                  5                   14                   12                    22                    53                    21                    127                  149                  42

  IGL454F                35                  9                   9                    15                    26                    41                    35                    135                  170                  89

  IGL461F                28                  -3                  19                   8                     21                    35                    18                    98                   126                  39

  IGL469F                19                  -4                  3                    7                     5                     12                    24                    47                   66                   45

  IGL470F                36                  9                   10                   14                    42                    56                    9                     140                  176                  55

  IGL473F                22                  -12                 9                    17                    35                    57                    13                    119                  141                  24

  IGL407F                22                  6                   9                    10                    30                    65                    25                    145                  167                  47

  IGL442F                27                  5                   12                   9                     31                    38                    20                    115                  142                  44
  ---------------------- ------------------- ------------------- -------------------- --------------------- --------------------- --------------------- --------------------- -------------------- -------------------- ---------------------

C-9

  ---------------------- ------------------- ------------------- -------------------- --------------------- --------------------- --------------------- --------------------- -------------------- -------------------- ---------------------
  **APPENDIX C -                                                                                                                                                                                                        
  GESTATION BODY WEIGHT                                                                                                                                                                                                 
  AND BODY WEIGHT                                                                                                                                                                                                       
  CHANGE**                                                                                                                                                                                                              

  **(INDIVIDUAL                                                                                                                                                                                                         
  GESTATION BODY WEIGHT                                                                                                                                                                                                 
  CHANGE BY TARGET                                                                                                                                                                                                      
  DOSE)**                                                                                                                                                                                                               

  **(GRAMS)**                                                                                                                                                                                                           

  **DOSE: 20,000                                                                                                                                                                                                        
  MG/M^3^**                                                                                                                                                                                                             

  ANIMAL                 GD                  GD                  GD                   GD                    GD                    GD                    GD                    GD                   GD                   GD

  [NUMBER]{.underline}   [0-5]{.underline}   [5-8]{.underline}   [8-11]{.underline}   [11-14]{.underline}   [14-17]{.underline}   [17-20]{.underline}   [20-21]{.underline}   [5-21]{.underline}   [0-21]{.underline}   [0-21C]{.underline}

  IGL364F                20                  0                   7                    13                    26                    57                    16                    119                  139                  16

  IGL367F                46                  -5                  11                   14                    33                    50                    14                    117                  163                  57

  IGL368F                27                  3                   13                   11                    32                    42                    20                    121                  148                  38

  IGL375F                31                  -7                  10                   9                     25                    47                    21                    105                  136                  51

  IGL363F                17                  9                   9                    7                     20                    29                    9                     83                   100                  48

  IGL373F                20                  -7                  7                    7                     29                    43                    16                    95                   115                  22

  IGL397F                22                  -4                  8                    9                     30                    51                    21                    115                  137                  19

  IGL357F                35                  -6                  12                   13                    23                    42                    16                    100                  135                  38

  IGL369F                30                  1                   13                   11                    27                    46                    17                    115                  145                  44

  IGL404F                28                  4                   9                    10                    29                    51                    16                    119                  147                  43

  IGL365F                14                  6                   2                    13                    30                    53                    15                    119                  133                  23

  IGL366F                18                  7                   4                    11                    34                    44                    21                    121                  139                  27

  IGL372F                25                  3                   3                    14                    38                    49                    16                    123                  148                  38

  IGL396F                4                   12                  11                   18                    41                    46                    17                    145                  149                  42

  IGL371F                26                  -2                  8                    9                     28                    49                    27                    119                  145                  38

  IGL410F                29                  7                   2                    13                    28                    56                    14                    120                  149                  44

  IGL415F                17                  26                  5                    13                    35                    48                    23                    150                  167                  43

  IGL444F                38                  -2                  10                   15                    21                    46                    23                    113                  151                  46

  IGL449F                23                  14                  6                    13                    32                    55                    19                    139                  162                  49

  IGL451F NP                                                                                                                                                                                                            

  IGL458F                22                  1                   11                   7                     38                    53                    14                    124                  146                  37

  IGL471F                15                  1                   12                   6                     21                    38                    18                    96                   111                  26

  IGL424F                36                  9                   12                   7                     43                    47                    39                    157                  193                  80

  IGL428F                46                  0                   9                    3                     21                    50                    23                    106                  152                  37

  IGL439F                25                  11                  7                    3                     34                    42                    15                    112                  137                  27

                                                                                                                                                                                                                        

  NOTE:                  NP - ANIMAL NOT                                                                    GD - GESTATION DAY                                                B - APPARENT BAD                          
                         PREGNANT                                                                                                                                             VALUE                                     

                         C - CALCULATION                                                                                                                                                                                
                         COULD NOT BE                                                                                                                                                                                   
                         PERFORMED DUE TO A                                                                                                                                                                             
                         BAD VALUE IN THE                                                                                                                                                                               
                         GD21 WEIGHT                                                                                                                                                                                    

                         21C (DAY 21                                                                                                                                                                                    
                         CORRECTED) = DAY 21                                                                                                                                                                            
                         BODY WEIGHT -                                                                                                                                                                                  
                         UTERINE WEIGHT                                                                                                                                                                                 
  ---------------------- ------------------- ------------------- -------------------- --------------------- --------------------- --------------------- --------------------- -------------------- -------------------- ---------------------

C-10

  --------------- ------------------ ------------------ ------ -- ------------------- -------------------- -- -------------------- -------------------- -------------------- ------------------- -------------------
  **APPENDIX D -                                                                                                                                                                                 
  GESTATION FOOD                                                                                                                                                                                 
  CONSUMPTION**                                                                                                                                                                                  

  **(MEAN                                                                                                                                                                                        
  GESTATION FOOD                                                                                                                                                                                 
  CONSUMPTION BY                                                                                                                                                                                 
  TARGET DOSE)**                                                                                                                                                                                 

  **(SEE LIST OF                                                                                                                                                                                 
  ABBREVIATIONS                                                                                                                                                                                  
  FOR STATISTICAL                                                                                                                                                                                
  SYMBOLS ON                                                                                                                                                                                     
  PAGES 5-1 AND                                                                                                                                                                                  
  5-2)**                                                                                                                                                                                         

  **(GRAMS)**                                                                                                                                                                                    

                                                                                                                                                                                                 

                  [GD                [GD                          [GD                 [GD                     [GD                  [GD                  [GD                  [GD                 [GD
                  0-5]{.underline}   5-8]{.underline}             8-11]{.underline}   11-14]{.underline}      14-17]{.underline}   17-20]{.underline}   20-21]{.underline}   5-20]{.underline}   0-21]{.underline}

  FEMALE          A-L-               A-L+                         A+L+                A+L+                    A-L-                 A-L                  A-L-                 AL+                 A-L+

  0 MG/M^3^                                                                                                                                                                                      

  MEAN            119.6              70.6                         69.6                72.4                    71.7                 77.3                 24.5                 361.5               505.6

  STD.DEV.        13.1               8.4                          7.8                 7.4                     10.7                 9.2                  4.4                  36.6                49.6

  \(N\)           25                 25                           25                  25                      25                   25                   25                   25                  25

                                                                                                                                                                                                 

  2000 MG/M^3^                                                                                                                                                                                   

  MEAN            115.8              69.8                         67.8                68.8                    71.4                 78.2                 24.2                 356                 496

  STD.DEV.        12.8               7.2                          7.1                 9.7                     9.4                  6.9                  3.3                  33.9                46.5

  \(N\)           23                 23                           23                  23                      23                   23                   23                   23                  23

                                                                                                                                                                                                 

  10,000 MG/M^3^                                                  \*                                                                                                                             

  MEAN            118.4              67.3                         63.8                67.5                    68.7                 75                   23.2                 342.3               483.8

  STD.DEV.        13.4               8.1                          7.5                 5.8                     6.4                  7.4                  5.4                  30.8                42.6

  \(N\)           24                 24                           24                  24                      24                   24                   24                   24                  24

                                                                                                                                                                                                 

                                                                                                                                                                                                 

  20,000 MG/M^3^                                                  \*\*                \*\*                                                                                   \*                  

  MEAN            117.3              64.9                         61.0                64.1                    68.3                 74                   22.9                 332.4               472.5

  STD.DEV.        14.5               8.5                          5.8                 6.5                     6.7                  6.3                  3.7                  29.5                43.1

  \(N\)           24                 24                           24                  24                      24                   24                   24                   24                  24

                                                                                                                                                                                                 

  NOTE: GD -                                                                                                                                                                                     
  GESTATION DAY                                                                                                                                                                                  

                                                                                                                                                                                                 

                                                                                                                                                                                                 
  --------------- ------------------ ------------------ ------ -- ------------------- -------------------- -- -------------------- -------------------- -------------------- ------------------- -------------------

D-1

  ---------------------- ------------------- ------------------- -------------------- --------------------- --------------------- --------------------- ---------------------
  **APPENDIX D -                                                                                                                                        
  GESTATION FOOD                                                                                                                                        
  CONSUMPTION**                                                                                                                                         

  **(INDIVIDUAL                                                                                                                                         
  GESTATION FOOD                                                                                                                                        
  CONSUMPTION)**                                                                                                                                        

  **(GRAMS)**                                                                                                                                           

  **TARGET DOSE: 0                                                                                                                                      
  MG/M^3^**                                                                                                                                             

  ANIMAL                 GD                  GD                  GD                   GD                    GD                    GD                    GD

  [NUMBER]{.underline}   [0-5]{.underline}   [5-8]{.underline}   [8-11]{.underline}   [11-14]{.underline}   [14-17]{.underline}   [17-20]{.underline}   [20-21]{.underline}

  IGL359F                100                 60                  55                   57                    64                    66                    27

  IGL360F                107                 63                  63                   65                    68                    72                    21

  IGL370F                123                 68                  73                   75                    77                    62                    12

  IGL374F                113                 58                  63                   65                    62                    67                    22

  IGL395F                119                 67                  67                   73                    81                    83                    25

  IGL383F                110                 69                  66                   75                    77                    78                    29

  IGL386F                110                 60                  62                   69                    68                    72                    19

  IGL394F                114                 64                  65                   73                    71                    76                    22

  IGL402F                132                 75                  71                   76                    78                    85                    33

  IGL411F                115                 70                  69                   77                    76                    73                    23

  IGL422F                114                 66                  70                   78                    77                    81                    23

  IGL347F                133                 84                  77                   79                    75                    84                    25

  IGL427F                120                 69                  72                   71                    58                    75                    21

  IGL400F                110                 70                  78                   85                    89                    92                    27

  IGL408F                130                 84                  80                   79                    81                    87                    31

  IGL393F                110                 68                  64                   63                    60                    66                    25

  IGL419F                106                 70                  59                   63                    63                    67                    24

  IGL434F                139                 86                  82                   83                    83                    94                    27

  IGL445F                113                 68                  67                   69                    65                    70                    24

  IGL446F                114                 69                  64                   63                    67                    66                    25

  IGL465F                162                 92                  88                   77                    83                    85                    31

  IGL490F                131                 71                  77                   81                    85                    88                    29

  IGL406F                124                 70                  70                   68                    69                    80                    22

  IGL418F                125                 77                  75                   80                    75                    74                    22

  IGL474F                115                 66                  64                   65                    40                    89                    24
  ---------------------- ------------------- ------------------- -------------------- --------------------- --------------------- --------------------- ---------------------

D-2

  ---------------------- ------------------- ------------------- -------------------- --------------------- --------------------- --------------------- ---------------------
  **APPENDIX D -                                                                                                                                        
  GESTATION FOOD                                                                                                                                        
  CONSUMPTION**                                                                                                                                         

  **(INDIVIDUAL                                                                                                                                         
  GESTATION FOOD                                                                                                                                        
  CONSUMPTION)**                                                                                                                                        

  **(GRAMS)**                                                                                                                                           

  **TARGET DOSE: 2000                                                                                                                                   
  MG/M^3^**                                                                                                                                             

  ANIMAL                 GD                  GD                  GD                   GD                    GD                    GD                    GD

  [NUMBER]{.underline}   [0-5]{.underline}   [5-8]{.underline}   [8-11]{.underline}   [11-14]{.underline}   [14-17]{.underline}   [17-20]{.underline}   [20-21]{.underline}

  IGL346F                117                 74                  72                   71                    71                    75                    26

  IGL361F                113                 69                  62                   73                    70                    80                    19

  IGL376F                97                  60                  59                   65                    69                    72                    20

  IGL381F                112                 62                  62                   62                    61                    71                    20

  IGL405F                112                 67                  62                   73                    72                    77                    25

  IGL382F                116                 74                  71                   75                    77                    82                    25

  IGL390F                118                 69                  59                   61                    65                    69                    20

  IGL358F                113                 65                  64                   68                    75                    77                    22

  IGL398F                103                 66                  61                   66                    72                    76                    21

  IGL350F                103                 65                  67                   66                    73                    76                    28

  IGL353F                142                 80                  78                   83                    90                    93                    27

  IGL420F                126                 74                  76                   83                    79                    89                    24

  IGL435F NP                                                                                                                                            

  IGL388F                132                 75                  73                   72                    72                    76                    25

  IGL413F                111                 72                  64                   63                    76                    81                    22

  IGL455F NP                                                                                                                                            

  IGL414F                103                 76                  63                   69                    71                    71                    24

  IGL433F                111                 68                  76                   40                    42                    79                    31

  IGL441F                110                 72                  66                   73                    73                    72                    21

  IGL457F                105                 62                  62                   61                    61                    71                    22

  IGL466F                115                 74                  70                   64                    69                    79                    27

  IGL475F                153                 89                  87                   88                    88                    94                    29

  IGL488F                117                 57                  66                   63                    69                    72                    24

  IGL432F                124                 73                  74                   76                    78                    85                    28

  IGL477F                110                 63                  65                   67                    69                    82                    26
  ---------------------- ------------------- ------------------- -------------------- --------------------- --------------------- --------------------- ---------------------

D-3

  ---------------------- ------------------- ------------------- -------------------- --------------------- --------------------- --------------------- ---------------------
  **APPENDIX D -                                                                                                                                        
  GESTATION FOOD                                                                                                                                        
  CONSUMPTION**                                                                                                                                         

  **(INDIVIDUAL                                                                                                                                         
  GESTATION FOOD                                                                                                                                        
  CONSUMPTION)**                                                                                                                                        

  **(GRAMS)**                                                                                                                                           

  **TARGET DOSE: 10,000                                                                                                                                 
  MG/M^3^**                                                                                                                                             

  ANIMAL                 GD                  GD                  GD                   GD                    GD                    GD                    GD

  [NUMBER]{.underline}   [0-5]{.underline}   [5-8]{.underline}   [8-11]{.underline}   [11-14]{.underline}   [14-17]{.underline}   [17-20]{.underline}   [20-21]{.underline}

  IGL379F                116                 66                  65                   71                    72                    76                    23

  IGL389F                121                 77                  73                   74                    79                    84                    26

  IGL391F                127                 68                  67                   68                    72                    83                    29

  IGL352F                114                 68                  52                   63                    61                    67                    22

  IGL355F                126                 65                  62                   61                    67                    69                    23

  IGL417F                129                 73                  68                   75                    70                    81                    27

  IGL378F                81                  65                  56                   63                    64                    71                    21

  IGL380F                102                 63                  62                   66                    67                    75                    25

  IGL348F                123                 64                  64                   62                    64                    73                    26

  IGL430F                108                 65                  59                   63                    62                    67                    22

  IGL409F                143                 81                  74                   70                    77                    73                    24

  IGL421F                115                 63                  64                   65                    68                    71                    22

  IGL385F NP                                                                                                                                            

  IGL423F                141                 83                  78                   79                    79                    85                    24

  IGL440F                118                 67                  64                   72                    71                    73                    26

  IGL399F                102                 60                  56                   60                    63                    73                    22

  IGL452F                116                 68                  59                   64                    62                    69                    26

  IGL436F                128                 76                  67                   70                    65                    76                    27

  IGL454F                122                 73                  70                   77                    72                    87                    27

  IGL461F                107                 57                  62                   68                    67                    72                    25

  IGL469F                106                 55                  52                   56                    54                    55                    20

  IGL470F                132                 76                  73                   74                    80                    84                    24

  IGL473F                121                 48                  50                   64                    72                    80                    23

  IGL407F                117                 65                  61                   65                    71                    83                    0

  IGL442F                126                 69                  73                   69                    69                    74                    23
  ---------------------- ------------------- ------------------- -------------------- --------------------- --------------------- --------------------- ---------------------

D-4

  ---------------------- ------------------- ------------------- -------------------- --------------------- --------------------- --------------------- ---------------------
  **APPENDIX D -                                                                                                                                        
  GESTATION FOOD                                                                                                                                        
  CONSUMPTION**                                                                                                                                         

  **(INDIVIDUAL                                                                                                                                         
  GESTATION FOOD                                                                                                                                        
  CONSUMPTION)**                                                                                                                                        

  **(GRAMS)**                                                                                                                                           

  **TARGET DOSE: 20,000                                                                                                                                 
  MG/M^3^**                                                                                                                                             

  ANIMAL                 GD                  GD                  GD                   GD                    GD                    GD                    GD

  [NUMBER]{.underline}   [0-5]{.underline}   [5-8]{.underline}   [8-11]{.underline}   [11-14]{.underline}   [14-17]{.underline}   [17-20]{.underline}   [20-21]{.underline}

  IGL364F                111                 62                  56                   60                    59                    68                    19

  IGL367F                117                 61                  60                   68                    73                    80                    22

  IGL368F                125                 71                  69                   73                    75                    75                    24

  IGL375F                121                 52                  58                   62                    70                    76                    24

  IGL363F                98                  61                  54                   58                    63                    68                    18

  IGL373F                109                 51                  51                   57                    64                    69                    21

  IGL397F                108                 63                  56                   56                    62                    71                    21

  IGL357F                119                 58                  61                   63                    65                    70                    19

  IGL369F                108                 59                  62                   67                    65                    69                    22

  IGL404F                111                 64                  60                   60                    65                    75                    22

  IGL365F                98                  58                  53                   54                    59                    65                    20

  IGL366F                111                 63                  60                   64                    67                    71                    22

  IGL372F                124                 66                  61                   66                    73                    82                    23

  IGL396F                93                  65                  67                   76                    82                    80                    22

  IGL371F                127                 63                  64                   63                    68                    73                    26

  IGL410F                131                 71                  61                   67                    75                    86                    26

  IGL415F                116                 76                  64                   67                    75                    74                    23

  IGL444F                134                 79                  65                   68                    68                    71                    26

  IGL449F                122                 75                  66                   68                    71                    78                    26

  IGL451F NP                                                                                                                                            

  IGL458F                101                 57                  57                   55                    62                    68                    21

  IGL471F                108                 54                  53                   56                    64                    67                    23

  IGL424F                140                 79                  71                   77                    85                    90                    36

  IGL428F                156                 80                  74                   72                    63                    79                    24

  IGL439F                127                 70                  62                   62                    66                    71                    19

                                                                                                                                                        

  NOTE:                  GD - GESTATION DAY                                           NP - NOT PREGNANT                                                 
  ---------------------- ------------------- ------------------- -------------------- --------------------- --------------------- --------------------- ---------------------

D-5

**APPENDIX E - GROSS POSTMORTEM OBSERVATIONS**

**(INCIDENCE OF GROSS POSTMORTEM OBSERVATIONS)**

+----------------+-------+----+-------+--------+----------+----------+
| TARGET         |       |    | FE    |        |          |          |
|                |       |    | MALES |        |          |          |
+----------------+-------+----+-------+--------+----------+----------+
|                |       |    | 0     | 2000   | 10,000   | 20,000   |
|                |       |    | MG    | M      | MG/M^3^  | MG/M^3^  |
|                |       |    | /M^3^ | G/M^3^ |          |          |
+----------------+-------+----+-------+--------+----------+----------+
| TOTAL AT       |       |    | 25    | 25     | 25       | 25       |
| TERMINAL       |       |    |       |        |          |          |
| SACRIFICE (A)  |       |    |       |        |          |          |
+----------------+-------+----+-------+--------+----------+----------+
| NO OBSERVABLE  |       |    | 21    | 25     | 25       | 24       |
| ABNORMALITIES  |       |    |       |        |          |          |
+----------------+-------+----+-------+--------+----------+----------+
| UTERUS:        |       |    | 1     | 0      | 0        | 0        |
| Diverticulum   |       |    |       |        |          |          |
+----------------+-------+----+-------+--------+----------+----------+
| Alopecia Trunk |       |    | 3     | 0      | 0        | 1        |
+----------------+-------+----+-------+--------+----------+----------+
| NO EVIDENCE OF |       |    | 0     | 2      | 1        | 1        |
| UTERINE        |       |    |       |        |          |          |
|                |       |    |       |        |          |          |
| IMPLANTATION   |       |    |       |        |          |          |
| SITES          |       |    |       |        |          |          |
+----------------+-------+----+-------+--------+----------+----------+
| NOTE: (A) -    |       |    |       |        |          |          |
| INCLUDES       |       |    |       |        |          |          |
| NON-PREGNANT   |       |    |       |        |          |          |
| ANIMALS        |       |    |       |        |          |          |
+----------------+-------+----+-------+--------+----------+----------+

E-1

**APPENDIX E - GROSS POSTMORTEM OBSERVATIONS**

**(INDIVIDUAL GROSS POSTMORTEM OBSERVATIONS)**

**TARGET DOSE: 0 MG/M^3^**

IGL359F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL360F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL370F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL374F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL395F - GENERAL CONDITION: Alopecia trunk.

IGL383F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL386F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL394F - GENERAL CONDITION: Alopecia trunk.

IGL402F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL411F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL422F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL347F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL427F - UTERUS (Right horn): Diverticulum, contains extreme amount of
liquid.

IGL400F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL408F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL393F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL419F - ALL TISSUES AND ORGANS: No observable abnormalities.

E-2

**APPENDIX E - GROSS POSTMORTEM OBSERVATIONS**

**(INDIVIDUAL GROSS POSTMORTEM OBSERVATIONS)**

**TARGET DOSE: 0 MG/M^3^ (CONT\'D)**

IGL434F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL445F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL446F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL465F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL490F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL406F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL418F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL474F - GENERAL CONDITION: Alopecia trunk.

E-3

**APPENDIX E - GROSS POSTMORTEM OBSERVATIONS**

**(INDIVIDUAL GROSS POSTMORTEM OBSERVATIONS)**

**TARGET DOSE: 2000 MG/M^3^**

IGL346F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL361F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL376F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL381F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL405F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL382F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL390F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL358F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL398F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL350F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL353F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL420F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL435F - ALL TISSUES AND ORGANS: No observable abnormalities.

NOTE: No evidence of uterine implantation sites.

IGL388F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL413F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL455F - ALL TISSUES AND ORGANS: No observable abnormalities.

NOTE: No evidence of uterine implantation sites.

IGL414F - ALL TISSUES AND ORGANS: No observable abnormalities.

E-4

**APPENDIX E - GROSS POSTMORTEM OBSERVATIONS**

**(INDIVIDUAL GROSS POSTMORTEM OBSERVATIONS)**

**TARGET DOSE: 2000 MG/M^3^ (CONT\'D)**

IGL433F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL441F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL457F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL466F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL475F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL488F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL432F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL477F - ALL TISSUES AND ORGANS: No observable abnormalities.

E-5

**APPENDIX E - GROSS POSTMORTEM OBSERVATIONS**

**(INDIVIDUAL GROSS POSTMORTEM OBSERVATIONS)**

**TARGET DOSE: 10,000 MG/M^3^**

IGL379F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL389F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL391F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL352F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL355F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL417F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL378F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL380F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL348F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL430F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL409F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL421F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL385F - ALL TISSUES AND ORGANS: No observable abnormalities.

NOTE: No evidence of uterine implantation sites.

IGL423F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL440F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL399F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL452F - ALL TISSUES AND ORGANS: No observable abnormalities.

E-6

**APPENDIX E - GROSS POSTMORTEM OBSERVATIONS**

**(INDIVIDUAL GROSS POSTMORTEM OBSERVATIONS)**

**TARGET DOSE: 10,000 MG/M^3^ (CONT\'D)**

IGL436F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL454F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL461F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL469F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL470F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL473F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL407F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL442F - ALL TISSUES AND ORGANS: No observable abnormalities.

E-7

**APPENDIX E - GROSS POSTMORTEM OBSERVATIONS**

**(INDIVIDUAL GROSS POSTMORTEM OBSERVATIONS)**

**TARGET DOSE: 20,000 MG/M^3^**

IGL364F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL367F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL368F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL375F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL363F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL373F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL397F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL357F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL369F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL404F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL365F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL366F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL372F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL396F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL371F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL410F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL415F - ALL TISSUES AND ORGANS: No observable abnormalities.

E-8

**APPENDIX E - GROSS POSTMORTEM OBSERVATIONS**

**(INDIVIDUAL GROSS POSTMORTEM OBSERVATIONS)**

**TARGET DOSE: 20,000 MG/M^3^ (CONT\'D)**

IGL444F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL449F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL451F - ALL TISSUES AND ORGANS: No observable abnormalities.

NOTE: No evidence of uterine implantation sites.

IGL458F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL471F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL424F - ALL TISSUES AND ORGANS: No observable abnormalities.

IGL428F - ALL TISSUES AND ORGANS: No observable abnormalities

IGL439F - GENERAL CONDITION: Alopecia trunk.

E-9

  --------------- -------------------- ----------------------- ----------------------- --------------------------- --------------------- --------------------- -------------------- ---------------------------- ----------------------------
  **APPENDIX F -                                                                                                                                                                                                 
  UTERINE                                                                                                                                                                                                        
  IMPLANTATION                                                                                                                                                                                                   
  DATA**                                                                                                                                                                                                         

  **(MEAN UTERINE                                                                                                                                                                                                
  IMPLANTATION                                                                                                                                                                                                   
  DATA BY TARGET                                                                                                                                                                                                 
  DOSE)**                                                                                                                                                                                                        

  **(SEE LIST OF                                                                                                                                                                                                 
  ABBREVIATIONS                                                                                                                                                                                                  
  FOR STATISTICAL                                                                                                                                                                                                
  SYMBOLS ON                                                                                                                                                                                                     
  PAGES 5-1 AND                                                                                                                                                                                                  
  5-2)**                                                                                                                                                                                                         

                                                                                                                                                                                                                 

                  Total                Male                    Female                                              Implantation          Corpora               Total                Fetuses/                     Resorptions/

                  [Live]{.underline}   [Fetuses]{.underline}   [Fetuses]{.underline}   [Resorptions]{.underline}   [Sites]{.underline}   [Lutea]{.underline}   [Dead]{.underline}   [Implantation]{.underline}   [Implantation]{.underline}

  FEMALE          A-L-                 A-L-                    A-L-                    K-J-                        A-L-                  A-L-                  K-J-                 K-J-                         K-J-

                                                                                                                                                                                                                 

  0 MG/M^3^                                                                                                                                                                                                      

  MEAN            14.12                6.88                    7.24                    0.4                         14.56                 15.88                 0.04                 0.95                         0.04

  STD.DEV.        3.11                 2.44                    2.15                    0.58                        3                     1.54                  0.2                  0.1                          0.1

  \(N\)           25                   25                      25                      25                          25                    25                    25                   25                           25

                                                                                                                                                                                                                 

  2000 MG/M^3^                                                                                                                                                                                                   

  MEAN            14.3                 6.61                    7.7                     0.61                        14.91                 15.96                 0                    0.96                         0.04

  STD.DEV.        3.4                  2.54                    2.46                    1.31                        3.36                  2.57                  0                    0.08                         0.08

  \(N\)           23                   23                      23                      23                          23                    23                    23                   23                           23

                                                                                                                                                                                                                 

  10,000 MG/M^3^                                                                                                                                                                                                 

  MEAN            13.54                7.13                    6.42                    0.58                        14.13                 15                    0                    0.96                         0.04

  STD.DEV.        3.95                 2.86                    2.75                    0.78                        4.07                  2.9                   0                    0.05                         0.05

  \(N\)           24                   24                      24                      24                          24                    24                    24                   24                           24

                                                                                                                                                                                                                 

  20,000 MG/M^3^                                                                                                                                                                                                 

  MEAN            14.25                7.13                    7.13                    0.33                        14.63                 15.08                 0.04                 0.98                         0.02

  STD.DEV.        2.27                 2.07                    2.13                    0.48                        2.32                  2.24                  0.2                  0.03                         0.03

  \(N\)           24                   24                      24                      24                          24                    24                    24                   24                           24

                                                                                                                                                                                                                 
  --------------- -------------------- ----------------------- ----------------------- --------------------------- --------------------- --------------------- -------------------- ---------------------------- ----------------------------

F-1

  --------------- -------------------- -------------------- -------------------- ---------------------------- -------------------- -------------------- ----------------------------- -------------------------- ------------------------
  **APPENDIX F -                                                                                                                                                                                                 
  UTERINE                                                                                                                                                                                                        
  IMPLANTATION                                                                                                                                                                                                   
  DATA**                                                                                                                                                                                                         

  **(MEAN UTERINE                                                                                                                                                                                                
  IMPLANTATION                                                                                                                                                                                                   
  DATA BY TARGET                                                                                                                                                                                                 
  DOSE)**                                                                                                                                                                                                        

  **(SEE LIST OF                                                                                                                                                                                                 
  ABBREVIATIONS                                                                                                                                                                                                  
  FOR STATISTICAL                                                                                                                                                                                                
  SYMBOLS ON                                                                                                                                                                                                     
  PAGES 5-1 AND                                                                                                                                                                                                  
  5-2)**                                                                                                                                                                                                         

                                                                                                                                                                                                                 

                  F/I                  R/I                  D/I                  Dead/                        \% Preimplant        \% Postimplant       Total                         Total                      Total

                  [Tran]{.underline}   [Tran]{.underline}   [Tran]{.underline}   [Implantation]{.underline}   [Loss]{.underline}   [Loss]{.underline}   [Malformations]{.underline}   [Variations]{.underline}   [Affected]{.underline}

  FEMALE          K-J-                 K-J-                 K-J-                 K-J-                         K-J-                 K-J-                 A-L-                          A-L-                       K-J-

                                                                                                                                                                                                                 

  0 MG/M^3^                                                                                                                                                                                                      

  MEAN            78.1                 11.6                 8.24                 0                            7.9                  4.6                  0.24                          1.7                        0.7

  STD.DEV.        8.03                 8.07                 2.93                 0                            17.7                 10.2                 0.44                          1.2                        0.8

  \(N\)           25                   25                   25                   25                           25                   25                   25                            25                         25

                                                                                                                                                                                                                 

  2000 MG/M^3^                                                                                                                                                                                                   

  MEAN            78.4                 11.6                 7.71                 0                            7.5                  3.8                  0.17                          1.3                        0.8

  STD.DEV.        6.85                 6.85                 1.64                 0                            14.2                 7.8                  0.39                          1.4                        1.3

  \(N\)           23                   23                   23                   23                           23                   23                   23                            23                         23

                                                                                                                                                                                                                 

  10,000 MG/M^3^                                                                                                                                                                                                 

  MEAN            77.5                 12.5                 8.30                 0                            7.8                  3.8                  0.08                          1.9                        0.7

  STD.DEV.        5.60                 5.60                 3.07                 0                            19                   5.2                  0.28                          1.8                        0.8

  \(N\)           24                   24                   24                   24                           24                   24                   24                            24                         24

                                                                                                                                                                                                                 

  20,000 MG/M^3^                                                                                                                                                                                                 

  MEAN            79.6                 10.1                 7.93                 0                            3.2                  2.5                  0.08                          1.8                        0.5

  STD.DEV.        3.68                 3.63                 1.70                 0                            4.4                  3.3                  0.28                          1.5                        0.5

  \(N\)           24                   24                   24                   24                           24                   24                   24                            24                         24

                                                                                                                                                                                                                 
  --------------- -------------------- -------------------- -------------------- ---------------------------- -------------------- -------------------- ----------------------------- -------------------------- ------------------------

F-2

  ---------------------- -------------------- -------------------- ---------------------- ---------------------- ------------------------ ------------------ -------------------- ------------------- -------------------
  **APPENDIX F - UTERINE                                                                                                                                                                              
  IMPLANTATION DATA**                                                                                                                                                                                 

  **(INDIVIDUAL UTERINE                                                                                                                                                                               
  IMPLANTATION DATA)**                                                                                                                                                                                

  **(SEE LIST OF                                                                                                                                                                                      
  ABBREVIATIONS ON PAGE                                                                                                                                                                               
  G-2 FOR                                                                                                                                                                                             
  ABBREVIATIONS)**                                                                                                                                                                                    

  **TARGET DOSE: 0                                                                                                                                                                                    
  MG/M^3^**                                                                                                                                                                                           

  ANIMAL                                                                                                                                                                                              

  [NUMBER]{.underline}   [Live]{.underline}   [Male]{.underline}   [Female]{.underline}   [Resorp]{.underline}   [Implants]{.underline}   [CL]{.underline}   [Dead]{.underline}   [Mal]{.underline}   [Var]{.underline}

  IGL359F                14                   7                    7                      0                      14                       17                 0                    0                   2

  IGL360F                15                   5                    10                     1                      16                       17                 0                    0                   3

  IGL370F                16                   9                    7                      0                      17                       17                 1                    0                   2

  IGL374F                14                   7                    7                      1                      15                       15                 0                    1                   2

  IGL395F                16                   12                   4                      0                      16                       16                 0                    0                   2

  IGL383F                15                   9                    6                      0                      15                       15                 0                    0                   1

  IGL386F                14                   10                   4                      0                      14                       14                 0                    0                   2

  IGL394F                15                   6                    9                      0                      15                       15                 0                    1                   2

  IGL402F                17                   7                    10                     0                      17                       18                 0                    1                   4

  IGL411F                13                   4                    9                      1                      14                       15                 0                    0                   2

  IGL422F                16                   9                    7                      0                      16                       17                 0                    0                   2

  IGL347F                15                   6                    9                      0                      15                       16                 0                    0                   2

  IGL427F                1                    0                    1                      1                      2                        17                 0                    0                   0

  IGL400F                18                   9                    9                      0                      18                       18                 0                    0                   3

  IGL408F                15                   6                    9                      0                      15                       15                 0                    0                   1

  IGL393F                13                   6                    7                      0                      13                       16                 0                    0                   0

  IGL419F                15                   5                    10                     0                      15                       15                 0                    0                   1

  IGL434F                17                   11                   6                      1                      18                       20                 0                    1                   0

  IGL445F                15                   7                    8                      0                      15                       16                 0                    0                   0

  IGL446F                14                   7                    7                      2                      16                       16                 0                    1                   3

  IGL465F                14                   6                    8                      0                      14                       15                 0                    0                   0

  IGL490F                12                   6                    6                      0                      12                       14                 0                    1                   3

  IGL406F                13                   7                    6                      1                      14                       14                 0                    0                   0

  IGL418F                12                   6                    6                      1                      13                       13                 0                    0                   4

  IGL474F                14                   5                    9                      1                      15                       16                 0                    0                   1
  ---------------------- -------------------- -------------------- ---------------------- ---------------------- ------------------------ ------------------ -------------------- ------------------- -------------------

F-3

  ---------------------- -------------------- -------------------- -------------------- ------ -------- -------- -------- ------ -------
  **APPENDIX F - UTERINE                                                                                                         
  IMPLANTATION DATA**                                                                                                            

  **(INDIVIDUAL UTERINE                                                                                                          
  IMPLANTATION DATA)**                                                                                                           

  **(SEE LIST OF                                                                                                                 
  ABBREVIATIONS ON PAGE                                                                                                          
  G-2 FOR                                                                                                                        
  ABBREVIATIONS)**                                                                                                               

  **TARGET DOSE: 0                                                                                                               
  MG/M^3^**                                                                                                                      

  ANIMAL                 F/I                  R/I                  D/I                                                           

  [NUMBER]{.underline}   [Tran]{.underline}   [Tran]{.underline}   [Tran]{.underline}                                            

  IGL359F                82.321               7.679                7.6795                                                        

  IGL360F                75.523               14.478               7.1808                                                        

  IGL370F                75.964               6.965                14.0363                                                       

  IGL374F                75.037               14.963               7.4176                                                        

  IGL395F                82.82                7.181                7.1808                                                        

  IGL383F                82.583               7.418                7.4176                                                        

  IGL386F                82.321               7.679                7.6795                                                        

  IGL394F                82.583               7.418                7.4176                                                        

  IGL402F                83.035               6.965                6.9653                                                        

  IGL411F                74.499               15.501               7.6795                                                        

  IGL422F                82.82                7.181                7.1808                                                        

  IGL347F                82.583               7.418                7.4176                                                        

  IGL427F                45.000               45.000               20.7049                                                       

  IGL400F                83.232               6.768                6.7681                                                        

  IGL408F                82.583               7.418                7.4176                                                        

  IGL393F                82.029               7.971                7.9712                                                        

  IGL419F                82.583               7.418                7.4176                                                        

  IGL434F                76.367               13.633               6.7681                                                        

  IGL445F                82.583               7.418                7.4176                                                        

  IGL446F                69.296               20.705               7.1808                                                        

  IGL465F                82.321               7.679                7.6795                                                        

  IGL490F                81.702               8.299                8.299                                                         

  IGL406F                74.499               15.501               7.6795                                                        

  IGL418F                73.898               16.102               7.9712                                                        

  IGL474F                75.037               14.963               7.4176                                                        
  ---------------------- -------------------- -------------------- -------------------- ------ -------- -------- -------- ------ -------

F-4

  ---------------------- -------------------- -------------------- ---------------------- ---------------------- ------------------------ ------------------ -------------------- ------------------- -------------------
  **APPENDIX F - UTERINE                                                                                                                                                                              
  IMPLANTATION DATA**                                                                                                                                                                                 

  **(INDIVIDUAL UTERINE                                                                                                                                                                               
  IMPLANTATION DATA)**                                                                                                                                                                                

  **(SEE LIST OF                                                                                                                                                                                      
  ABBREVIATIONS ON PAGE                                                                                                                                                                               
  G-2 FOR                                                                                                                                                                                             
  ABBREVIATIONS)**                                                                                                                                                                                    

  **TARGET DOSE: 2000                                                                                                                                                                                 
  MG/M^3^**                                                                                                                                                                                           

  ANIMAL                                                                                                                                                                                              

  [NUMBER]{.underline}   [Live]{.underline}   [Male]{.underline}   [Female]{.underline}   [Resorp]{.underline}   [Implants]{.underline}   [CL]{.underline}   [Dead]{.underline}   [Mal]{.underline}   [Var]{.underline}

  IGL346F                15                   7                    8                      0                      15                       15                 0                    0                   0

  IGL361F                15                   7                    8                      0                      15                       16                 0                    0                   1

  IGL376F                13                   7                    6                      1                      14                       15                 0                    0                   1

  IGL381F                11                   4                    7                      6                      17                       18                 0                    0                   1

  IGL405F                18                   9                    9                      0                      18                       19                 0                    0                   0

  IGL382F                15                   6                    9                      0                      15                       15                 0                    0                   1

  IGL390F                13                   3                    10                     1                      14                       14                 0                    0                   1

  IGL358F                18                   11                   7                      0                      18                       21                 0                    0                   0

  IGL398F                16                   10                   6                      0                      16                       16                 0                    0                   1

  IGL350F                16                   7                    9                      0                      16                       16                 0                    0                   0

  IGL353F                19                   7                    12                     0                      19                       20                 0                    1                   5

  IGL420F                13                   7                    6                      1                      14                       14                 0                    0                   0

  IGL435F NP                                                                                                                                                                                          

  IGL388F                14                   3                    11                     0                      14                       14                 0                    0                   1

  IGL413F                13                   7                    6                      0                      13                       15                 0                    0                   2

  IGL455F NP                                                                                                                                                                                          

  IGL414F                15                   8                    7                      2                      17                       17                 0                    0                   1

  IGL433F                16                   3                    13                     0                      16                       17                 0                    1                   5

  IGL441F                15                   8                    7                      1                      16                       17                 0                    0                   2

  IGL457F                12                   6                    6                      1                      13                       13                 0                    0                   3

  IGL466F                16                   9                    7                      1                      17                       17                 0                    0                   1

  IGL475F                4                    2                    2                      0                      4                        10                 0                    0                   1

  IGL488F                8                    4                    4                      0                      8                        13                 0                    0                   0

  IGL432F                19                   11                   8                      0                      19                       20                 0                    1                   2

  IGL477F                15                   6                    9                      0                      15                       15                 0                    1                   2
  ---------------------- -------------------- -------------------- ---------------------- ---------------------- ------------------------ ------------------ -------------------- ------------------- -------------------

F-5

  ---------------------- -------------------- -------------------- -------------------- ------ -------- -------- -------- ------ -------
  **APPENDIX F - UTERINE                                                                                                         
  IMPLANTATION DATA**                                                                                                            

  **(INDIVIDUAL UTERINE                                                                                                          
  IMPLANTATION DATA)**                                                                                                           

  **(SEE LIST OF                                                                                                                 
  ABBREVIATIONS ON PAGE                                                                                                          
  G-2 FOR                                                                                                                        
  ABBREVIATIONS)**                                                                                                               

  **TARGET DOSE: 2000                                                                                                            
  MG/M^3^**                                                                                                                      

  ANIMAL                 F/I                  R/I                  D/I                                                           

  [NUMBER]{.underline}   [Tran]{.underline}   [Tran]{.underline}   [Tran]{.underline}                                            

  IGL346F                82.583               7.418                7.4176                                                        

  IGL361F                82.583               7.418                7.4176                                                        

  IGL376F                74.499               15.501               7.6795                                                        

  IGL381F                53.553               36.448               6.9653                                                        

  IGL405F                83.232               6.768                6.7681                                                        

  IGL382F                82.583               7.418                7.4176                                                        

  IGL390F                74.499               15.501               7.6795                                                        

  IGL358F                83.232               6.768                6.7681                                                        

  IGL398F                82.82                7.181                7.1808                                                        

  IGL350F                82.82                7.181                7.1808                                                        

  IGL353F                83.414               6.587                6.5868                                                        

  IGL420F                74.499               15.501               7.6795                                                        

  IGL435F NP                                                                                                                     

  IGL388F                82.321               7.679                7.6795                                                        

  IGL413F                82.029               7.971                7.9712                                                        

  IGL455F NP                                                                                                                     

  IGL414F                69.941               20.06                6.9653                                                        

  IGL433F                82.82                7.181                7.1808                                                        

  IGL441F                75.523               14.478               7.1808                                                        

  IGL457F                73.898               16.102               7.9712                                                        

  IGL466F                75.964               14.036               6.9653                                                        

  IGL475F                75.523               14.478               14.4776                                                       

  IGL488F                79.818               10.182               10.1821                                                       

  IGL432F                83.414               6.587                6.5868                                                        

  IGL477F                82.583               7.418                7.4176                                                        
  ---------------------- -------------------- -------------------- -------------------- ------ -------- -------- -------- ------ -------

F-6

  ---------------------- -------------------- -------------------- ---------------------- ---------------------- ------------------------ ------------------ -------------------- ------------------- -------------------
  **APPENDIX F - UTERINE                                                                                                                                                                              
  IMPLANTATION DATA**                                                                                                                                                                                 

  **(INDIVIDUAL UTERINE                                                                                                                                                                               
  IMPLANTATION DATA)**                                                                                                                                                                                

  **(SEE LIST OF                                                                                                                                                                                      
  ABBREVIATIONS ON PAGE                                                                                                                                                                               
  G-2 FOR                                                                                                                                                                                             
  ABBREVIATIONS)**                                                                                                                                                                                    

  **TARGET DOSE: 10,000                                                                                                                                                                               
  MG/M^3^**                                                                                                                                                                                           

  ANIMAL                                                                                                                                                                                              

  [NUMBER]{.underline}   [Live]{.underline}   [Male]{.underline}   [Female]{.underline}   [Resorp]{.underline}   [Implants]{.underline}   [CL]{.underline}   [Dead]{.underline}   [Mal]{.underline}   [Var]{.underline}

  IGL379F                16                   8                    8                      0                      16                       16                 0                    0                   3

  IGL389F                16                   10                   6                      0                      16                       16                 0                    0                   0

  IGL391F                15                   8                    7                      2                      17                       17                 0                    0                   1

  IGL352F                14                   7                    7                      2                      16                       17                 0                    0                   2

  IGL355F                17                   8                    9                      0                      17                       17                 0                    0                   7

  IGL417F                16                   11                   5                      0                      16                       16                 0                    0                   2

  IGL378F                13                   8                    5                      2                      15                       15                 0                    0                   1

  IGL380F                15                   9                    6                      0                      15                       16                 0                    0                   2

  IGL348F                14                   10                   4                      1                      15                       15                 0                    1                   1

  IGL430F                4                    3                    1                      0                      4                        13                 0                    0                   0

  IGL409F                14                   3                    11                     0                      14                       15                 0                    0                   0

  IGL421F                12                   4                    8                      1                      13                       13                 0                    0                   0

  IGL385F NP                                                                                                                                                                                          

  IGL423F                18                   7                    11                     1                      19                       19                 0                    0                   0

  IGL440F                9                    7                    2                      0                      9                        9                  0                    0                   1

  IGL399F                17                   10                   7                      0                      17                       17                 0                    0                   3

  IGL452F                14                   7                    7                      1                      15                       16                 0                    0                   2

  IGL436F                15                   11                   4                      1                      16                       18                 0                    0                   1

  IGL454F                11                   4                    7                      2                      13                       13                 0                    0                   4

  IGL461F                11                   6                    5                      0                      11                       13                 0                    0                   3

  IGL469F                2                    1                    1                      0                      2                        6                  0                    0                   0

  IGL470F                18                   12                   6                      0                      18                       18                 0                    0                   4

  IGL473F                15                   7                    8                      1                      16                       16                 0                    0                   2

  IGL407F                16                   6                    10                     0                      16                       16                 0                    0                   5

  IGL442F                13                   4                    9                      0                      13                       13                 0                    1                   1
  ---------------------- -------------------- -------------------- ---------------------- ---------------------- ------------------------ ------------------ -------------------- ------------------- -------------------

F-7

  ---------------------- -------------------- -------------------- -------------------- ------ -------- -------- -------- ------ -------
  **APPENDIX F - UTERINE                                                                                                         
  IMPLANTATION DATA**                                                                                                            

  **(INDIVIDUAL UTERINE                                                                                                          
  IMPLANTATION DATA)**                                                                                                           

  **(SEE LIST OF                                                                                                                 
  ABBREVIATIONS ON PAGE                                                                                                          
  G-2 FOR                                                                                                                        
  ABBREVIATIONS)**                                                                                                               

  **TARGET DOSE: 10,000                                                                                                          
  MG/M^3^**                                                                                                                      

  ANIMAL                 F/I                  R/I                  D/I                                                           

  [NUMBER]{.underline}   [Tran]{.underline}   [Tran]{.underline}   [Tran]{.underline}                                            

  IGL379F                82.82                7.181                7.1808                                                        

  IGL389F                82.82                7.181                7.1808                                                        

  IGL391F                69.941               20.06                6.9653                                                        

  IGL352F                69.296               20.705               7.1808                                                        

  IGL355F                83.035               6.965                6.9653                                                        

  IGL417F                82.82                7.181                7.1808                                                        

  IGL378F                68.584               21.417               7.4176                                                        

  IGL380F                82.583               7.418                7.4176                                                        

  IGL348F                75.037               14.963               7.4176                                                        

  IGL430F                75.523               14.478               14.4776                                                       

  IGL409F                82.321               7.679                7.6795                                                        

  IGL421F                73.898               16.102               7.9712                                                        

  IGL385F NP                                                                                                                     

  IGL423F                76.738               13.263               6.5868                                                        

  IGL440F                80.406               9.594                9.5941                                                        

  IGL399F                83.035               6.965                6.9653                                                        

  IGL452F                75.037               14.963               7.4176                                                        

  IGL436F                75.523               14.478               7.1808                                                        

  IGL454F                66.907               23.094               7.9712                                                        

  IGL461F                81.33                8.671                8.6708                                                        

  IGL469F                69.296               20.705               20.7049                                                       

  IGL470F                83.232               6.768                6.7681                                                        

  IGL473F                75.523               14.478               7.1808                                                        

  IGL407F                82.82                7.181                7.1808                                                        

  IGL442F                82.029               7.971                7.9712                                                        
  ---------------------- -------------------- -------------------- -------------------- ------ -------- -------- -------- ------ -------

F-8

  ---------------------- -------------------- -------------------- ---------------------- ---------------------- ------------------------ ------------------ -------------------- ------------------- -------------------
  **APPENDIX F - UTERINE                                                                                                                                                                              
  IMPLANTATION DATA**                                                                                                                                                                                 

  **(INDIVIDUAL UTERINE                                                                                                                                                                               
  IMPLANTATION DATA)**                                                                                                                                                                                

  **(SEE LIST OF                                                                                                                                                                                      
  ABBREVIATIONS ON PAGE                                                                                                                                                                               
  G-2 FOR                                                                                                                                                                                             
  ABBREVIATIONS)**                                                                                                                                                                                    

  **TARGET DOSE: 20,000                                                                                                                                                                               
  MG/M^3^**                                                                                                                                                                                           

  ANIMAL                                                                                                                                                                                              

  [NUMBER]{.underline}   [Live]{.underline}   [Male]{.underline}   [Female]{.underline}   [Resorp]{.underline}   [Implants]{.underline}   [CL]{.underline}   [Dead]{.underline}   [Mal]{.underline}   [Var]{.underline}

  IGL364F                17                   10                   7                      0                      17                       17                 0                    0                   3

  IGL367F                15                   11                   4                      0                      15                       15                 0                    0                   2

  IGL368F                16                   10                   6                      0                      16                       16                 0                    0                   1

  IGL375F                11                   8                    3                      1                      12                       13                 0                    0                   2

  IGL363F                6                    5                    1                      0                      6                        7                  0                    0                   1

  IGL373F                13                   4                    9                      1                      14                       14                 0                    0                   1

  IGL397F                16                   8                    8                      0                      16                       17                 0                    0                   1

  IGL357F                15                   6                    9                      0                      16                       17                 1                    0                   5

  IGL369F                14                   5                    9                      1                      15                       16                 0                    0                   3

  IGL404F                14                   5                    9                      0                      14                       15                 0                    0                   0

  IGL365F                15                   9                    6                      1                      16                       16                 0                    0                   0

  IGL366F                15                   8                    7                      0                      15                       15                 0                    1                   1

  IGL372F                15                   10                   5                      1                      16                       16                 0                    0                   4

  IGL396F                14                   6                    8                      0                      14                       15                 0                    0                   0

  IGL371F                14                   6                    8                      1                      15                       16                 0                    0                   2

  IGL410F                15                   6                    9                      0                      15                       15                 0                    0                   4

  IGL415F                16                   9                    7                      0                      16                       17                 0                    1                   0

  IGL444F                14                   5                    9                      0                      14                       15                 0                    0                   3

  IGL449F                15                   7                    8                      0                      15                       15                 0                    0                   2

  IGL451F NP                                                                                                                                                                                          

  IGL458F                14                   6                    8                      0                      14                       14                 0                    0                   0

  IGL471F                11                   4                    7                      0                      11                       11                 0                    0                   0

  IGL424F                15                   8                    7                      1                      16                       17                 0                    0                   4

  IGL428F                16                   6                    10                     1                      17                       16                 0                    0                   2

  IGL439F                16                   9                    7                      0                      16                       17                 0                    0                   1

  NOTE:                  NP - ANIMAL NOT                                                                                                                                                              
                         PREGNANT                                                                                                                                                                     
  ---------------------- -------------------- -------------------- ---------------------- ---------------------- ------------------------ ------------------ -------------------- ------------------- -------------------

F-9

  ---------------------- -------------------- -------------------- -------------------- ------ -------- -------- -------- ------ -------
  **APPENDIX F - UTERINE                                                                                                         
  IMPLANTATION DATA**                                                                                                            

  **(INDIVIDUAL UTERINE                                                                                                          
  IMPLANTATION DATA)**                                                                                                           

  **(SEE LIST OF                                                                                                                 
  ABBREVIATIONS ON PAGE                                                                                                          
  G-2 FOR                                                                                                                        
  ABBREVIATIONS)**                                                                                                               

  **TARGET DOSE: 20,000                                                                                                          
  MG/M^3^**                                                                                                                      

  ANIMAL                 F/I                  R/I                  D/I                                                           

  [NUMBER]{.underline}   [Tran]{.underline}   [Tran]{.underline}   [Tran]{.underline}                                            

  IGL364F                83.035               6.965                6.9653                                                        

  IGL367F                82.583               7.418                7.4176                                                        

  IGL368F                82.82                7.181                7.1808                                                        

  IGL375F                73.222               16.779               8.299                                                         

  IGL363F                78.222               11.778               11.7783                                                       

  IGL373F                74.499               15.501               7.6795                                                        

  IGL397F                82.82                7.181                7.1808                                                        

  IGL357F                75.523               7.181                14.4776                                                       

  IGL369F                75.037               14.963               7.4176                                                        

  IGL404F                82.321               7.679                7.6795                                                        

  IGL365F                75.523               14.478               7.1808                                                        

  IGL366F                82.583               7.418                7.4176                                                        

  IGL372F                75.523               14.478               7.1808                                                        

  IGL396F                82.321               7.679                7.6795                                                        

  IGL371F                75.037               14.963               7.4176                                                        

  IGL410F                82.583               7.418                7.4176                                                        

  IGL415F                82.82                7.181                7.1808                                                        

  IGL444F                82.321               7.679                7.6795                                                        

  IGL449F                82.583               7.418                7.4176                                                        

  IGL451F NP                                                                                                                     

  IGL458F                82.321               7.679                7.6795                                                        

  IGL471F                81.33                8.671                8.6708                                                        

  IGL424F                75.523               14.478               7.1808                                                        

  IGL428F                75.964               14.036               6.9653                                                        

  IGL439F                82.82                7.181                7.1808                                                        

  NOTE:                  NP - ANIMAL NOT                                                                                         
                         PREGNANT                                                                                                
  ---------------------- -------------------- -------------------- -------------------- ------ -------- -------- -------- ------ -------

F-10

APPENDIX G -- FETAL BODY WEIGHT

  --------------- ----- --------------------- -------- ----------------------- ------- -------- --------
  **(MEAN FETAL                                                                                 
  BODY WEIGHTS BY                                                                               
  SEX)**                                                                                        

  Target                                                                                        
  Concentration                                                                                 

                        [MALES]{.underline}            [FEMALES]{.underline}                    

  0 mg/m^3^                                                                                     

  Mean                  5.46                           5.18                                     

  SD                    0.41                           0.39                                     

  \(N\)                 24                             25                                       

                                                                                                

  2000 mg/m^3^                                                                                  

  Mean                  5.45                           5.19                                     

  SD.                   0.38                           0.44                                     

  \(N\)                 23                             23                                       

                                                                                                

  10,000 mg/m^3^                                                                                

  Mean                  5.41                           5.19                                     

  SD                    0.44                           0.39                                     

  \(N\)                 24                             24                                       

                                                                                                

  20,000 mg/m^3^                                                                                

  Mean                  5.43                           5.11                                     

  SD                    0.47                           0.44                                     

  \(N\)                 24                             24                                       
  --------------- ----- --------------------- -------- ----------------------- ------- -------- --------

G-1

**APPENDIX G -- FETAL BODY WEIGHT**

**Mean fetal weight, the least squares mean fetal weight**

+-----------------+---------+---------+--------------+-----------------+
| Exposure Group  | n       | n       | observed     | Least squares   |
|                 | litters | fetuses | fetus mean   | fetus mean (gm) |
| (mg/m^3^)       |         |         | (gm)         |                 |
+-----------------+---------+---------+--------------+-----------------+
| 0               | 25      | 353     | 5.32         | 5.33            |
+-----------------+---------+---------+--------------+-----------------+
| 2,000           | 23      | 329     | 5.31         | 5.34            |
+-----------------+---------+---------+--------------+-----------------+
| 10,000          | 24      | 325     | 5.30         | 5.29            |
+-----------------+---------+---------+--------------+-----------------+
| 20,000          | 24      | 342     | 5.27         | 5.25            |
+-----------------+---------+---------+--------------+-----------------+

G-2

  --------------- ----- ------ ------ ------ ------ ------ ------ ------ ------ ------ ------ ------ ------ -- -- --------- ------- ------ --------- ---------
  **APPENDIX G -                                                                                                                                     
  FETAL BODY                                                                                                                                         
  WEIGHT**                                                                                                                                           

  **(INDIVIDUAL                                                                                                                                      
  AND MEAN FETAL                                                                                                                                     
  BODY WEIGHT AND                                                                                                                                    
  LITTER                                                                                                                                             
  WEIGHTS)**                                                                                                                                         

  **(GRAMS)**                                                                                                                                        

  **TARGET DOSE:                                                                                                                                     
  0 MG/M^3^**                                                                                                                                        

  ANIMAL                                                                                                          Litter                   Fetus     
                                                                                                                  Weights                  Weights   

  NUMBER          SEX                                                                                                                      Males     Females

  IGL359F         M     5.08   5.50   5.17   5.66   4.88   5.56   5.12                                                      72.12   Mean   5.28      5.02

  IGL359F         F     5.01   4.82   5.27   5.45   4.81   4.34   5.45                                                              S.D.   0.29      0.40

  IGL360F         M     5.18   5.58   5.65   5.43   5.83                                                                    78.15   Mean   5.53      5.05

  IGL360F         F     5.08   5.06   5.19   5.19   4.74   5.17   4.75   5.12   5.12   5.06                                         S.D.   0.24      0.17

  IGL370F         M     5.25   4.84   4.82   5.01   5.08   4.90   5.21   5.34   4.62                                        80.03   Mean   5.01      4.99

  IGL370F         F     4.66   5.07   5.14   5.40   5.42   4.50   4.77                                                              S.D.   0.23      0.36

  IGL374F         M     5.44   5.50   5.62   5.92   4.89   5.00   5.72                                                      73.78   Mean   5.44      5.10

  IGL374F         F     5.24   5.28   5.16   4.59   5.15   5.15   5.12                                                              S.D.   0.37      0.23

  IGL395F         M     5.44   5.88   5.76   5.76   5.64   5.73   5.48   5.94   5.78   5.68   6.02   5.65                   90.97   Mean   5.73      5.55

  IGL395F         F     5.43   5.83   5.56   5.39                                                                                   S.D.   0.17      0.20

  IGL383F         M     5.71   5.71   6.05   5.61   5.58   5.74   5.35   5.99   5.98                                        85.26   Mean   5.75      5.59

  IGL383F         F     5.56   5.41   6.12   5.60   5.55   5.30                                                                     S.D.   0.23      0.28

  IGL386F         M     5.07   5.39   5.59   5.48   5.40   5.98   5.43   5.74   5.61   5.16                                 74.89   Mean   5.49      5.01

  IGL386F         F     5.05   5.09   4.72   5.18                                                                                   S.D.   0.27      0.20

  IGL394F         M     6.26   5.90   5.62   5.95   5.98   5.84                                                             85.57   Mean   5.93      5.56

  IGL394F         F     5.87   5.72   5.76   5.65   5.14   5.69   5.44   5.64   5.11                                                S.D.   0.21      0.27

  IGL402F         M     5.98   5.77   6.00   5.71   5.49   5.83   3.19                                                      92.56   Mean   5.42      5.46

  IGL402F         F     5.77   5.37   5.88   5.56   5.10   5.06   5.31   5.59   5.50   5.45                                         S.D.   1.00      0.26

  IGL411F         M     5.80   6.53   5.99   5.96                                                                           73.10   Mean   6.07      5.42

  IGL411F         F     5.50   5.50   5.04   5.75   5.39   5.54   4.71   5.73   5.66                                                S.D.   0.32      0.34

  IGL422F         M     5.14   5.13   5.69   5.01   5.31   5.50   5.09   4.81   5.27                                        80.95   Mean   5.22      4.86

  IGL422F         F     4.70   5.05   4.89   5.01   5.19   4.30   4.86                                                              S.D.   0.26      0.29

  IGL347F         M     5.14   5.36   5.11   5.20   4.93   5.04                                                             74.35   Mean   5.13      4.84

  IGL347F         F     4.76   4.88   4.95   5.04   4.87   4.66   4.73   4.86   4.82                                                S.D.   0.15      0.12

  IGL427F         M                                                                                                         6.25    Mean   NA        6.25

  IGL427F         F     6.25                                                                                                        S.D.   NA        NA

  IGL400F         M     5.52   5.30   5.47   5.67   5.92   5.47   5.61   5.55   5.75                                        96.47   Mean   5.58      5.13

  IGL400F         F     5.37   4.85   5.18   5.32   5.15   4.49   4.96   5.24   5.65                                                S.D.   0.18      0.33

  IGL408F         M     5.24   5.53   5.16   5.14   5.72   5.56                                                             78.00   Mean   5.39      5.07

  IGL408F         F     5.14   4.96   5.07   4.99   5.33   5.10   5.13   4.99   4.94                                                S.D.   0.24      0.12
  --------------- ----- ------ ------ ------ ------ ------ ------ ------ ------ ------ ------ ------ ------ -- -- --------- ------- ------ --------- ---------

G-3

  --------------- ----- ------ -- ------ -- ------ -- ------ -- ------ -- ------ -- ------ -- ------ -- ------ -- ------ -- ------ -- -- -- -- -- ------ --------- ------- ------ --------- ---------
  **APPENDIX G -                                                                                                                                                                            
  FETAL BODY                                                                                                                                                                                
  WEIGHT**                                                                                                                                                                                  

  **(INDIVIDUAL                                                                                                                                                                             
  AND MEAN FETAL                                                                                                                                                                            
  BODY WEIGHT AND                                                                                                                                                                           
  LITTER                                                                                                                                                                                    
  WEIGHTS)**                                                                                                                                                                                

  **(GRAMS)**                                                                                                                                                                               

  **TARGET DOSE:                                                                                                                                                                            
  0 MG/M^3^**                                                                                                                                                                               

  ANIMAL                                                                                                                                                 Litter                   Fetus     
                                                                                                                                                         Weights                  Weights   

  NUMBER          SEX                                                                                                                                                             Males     Females

  IGL393F         M     5.33      5.28      5.21      5.15      5.25      4.78                                                                                     65.81   Mean   5.17      4.97

  IGL393F         F     5.31      5.40      5.03      4.51      4.97      4.80      4.79                                                                                   S.D.   0.20      0.31

  IGL419F         M     5.19      5.39      5.26      5.69      5.26                                                                                               77.59   Mean   5.36      5.08

  IGL419F         F     5.17      5.11      5.50      4.86      4.82      5.07      4.99      5.27      4.91      5.10                                                     S.D.   0.20      0.20

  IGL434F         M     5.31      4.19      5.42      5.12      5.22      5.08      5.34      5.33      5.58      5.08      5.48                                   86.63   Mean   5.20      4.91

  IGL434F         F     4.76      4.85      5.30      5.10      4.61      4.86                                                                                             S.D.   0.37      0.25

  IGL445F         M     5.64      5.28      5.39      3.64      5.57      5.41      5.05                                                                           76.27   Mean   5.14      5.04

  IGL445F         F     4.96      4.84      4.92      5.24      5.05      5.23      5.00      5.05                                                                         S.D.   0.69      0.14

  IGL446F         M     5.50      5.16      5.69      5.29      5.00      5.68      5.61                                                                           71.77   Mean   5.42      4.83

  IGL446F         F     4.53      4.94      4.82      5.16      4.46      4.98      4.95                                                                                   S.D.   0.27      0.25

  IGL465F         M     5.76      5.73      5.88      5.73      5.40      5.34                                                                                     76.86   Mean   5.64      5.38

  IGL465F         F     5.26      5.46      5.20      5.30      5.38      5.74      5.24      5.44                                                                         S.D.   0.22      0.17

  IGL490F         M     5.58      5.73      5.76      5.57      5.54      5.45                                                                                     63.46   Mean   5.61      4.97

  IGL490F         F     5.40      4.97      5.51      2.90      5.50      5.55                                                                                             S.D.   0.12      1.04

  IGL406F         M     5.33      5.89      6.17      5.70      5.40      5.66      5.45                                                                           71.38   Mean   5.66      5.30

  IGL406F         F     5.45      5.35      5.53      5.23      5.09      5.13                                                                                             S.D.   0.30      0.18

  IGL418F         M     5.95      5.88      5.37      5.78      5.93      5.46                                                                                     67.12   Mean   5.73      5.46

  IGL418F         F     5.15      5.22      5.53      5.47      5.69      5.69                                                                                             S.D.   0.25      0.23

  IGL474F         M     5.72      5.47      5.80      5.64      5.72                                                                                               77.95   Mean   5.67      5.51

  IGL474F         F     5.26      5.59      4.80      5.77      5.22      5.89      5.74      5.70      5.63                                                               S.D.   0.13      0.35

                                                                                                                                                  Mean             75.09                    

                                                                                                                                                         S.D.      16.48                    
  --------------- ----- ------ -- ------ -- ------ -- ------ -- ------ -- ------ -- ------ -- ------ -- ------ -- ------ -- ------ -- -- -- -- -- ------ --------- ------- ------ --------- ---------

G-4

  --------------- ----- ------ -- ------ -- ------ -- ------ -- ------ -- ------ -- ------ -- ------ -- ------ -- ------ -- ------ -- ------ -- -- -- -- --------- ------- ------ --------- ---------
  **APPENDIX G -                                                                                                                                                                            
  FETAL BODY                                                                                                                                                                                
  WEIGHT**                                                                                                                                                                                  

  **(INDIVIDUAL                                                                                                                                                                             
  AND MEAN FETAL                                                                                                                                                                            
  BODY WEIGHT AND                                                                                                                                                                           
  LITTER                                                                                                                                                                                    
  WEIGHTS)**                                                                                                                                                                                

  **(GRAMS)**                                                                                                                                                                               

  **TARGET DOSE:                                                                                                                                                                            
  2000 MG/M^3^**                                                                                                                                                                            

  ANIMAL                                                                                                                                                 Litter                   Fetus     
                                                                                                                                                         Weights                  Weights   

  NUMBER          SEX                                                                                                                                                             Males     Females

  IGL346F         M     5.06      4.97      5.21      5.35      4.84      5.04      5.21                                                                           75.51   Mean   5.10      4.98

  IGL346F         F     5.01      4.90      4.85      4.90      4.82      4.94      5.19      5.22                                                                         S.D.   0.17      0.15

  IGL361F         M     5.40      5.37      5.40      5.83      5.82      5.67      5.77                                                                           82.74   Mean   5.61      5.44

  IGL361F         F     5.11      5.54      5.24      5.83      5.72      5.51      5.32      5.21                                                                         S.D.   0.21      0.26

  IGL376F         M     5.62      5.54      5.20      5.66      5.74      5.61      5.62                                                                           71.56   Mean   5.57      5.43

  IGL376F         F     5.25      5.63      5.33      5.33      5.37      5.66                                                                                             S.D.   0.17      0.17

  IGL381F         M     5.28      4.26      5.84      4.97                                                                                                         56.12   Mean   5.09      5.11

  IGL381F         F     5.09      5.22      4.94      4.60      5.23      5.50      5.19                                                                                   S.D.   0.66      0.28

  IGL405F         M     5.10      5.38      5.29      5.34      5.40      5.62      5.36      5.26      5.14                                                       91.67   Mean   5.32      4.86

  IGL405F         F     4.81      4.82      4.94      4.80      4.97      4.91      4.87      4.65      5.01                                                               S.D.   0.15      0.11

  IGL382F         M     5.96      5.87      6.06      6.12      5.33      5.92                                                                                     85.40   Mean   5.88      5.57

  IGL382F         F     5.40      5.67      5.55      5.65      5.50      5.88      5.46      5.59      5.44                                                               S.D.   0.28      0.15

  IGL390F         M     5.52      5.46      5.63                                                                                                                   69.84   Mean   5.54      5.32

  IGL390F         F     4.86      5.24      5.42      5.42      5.19      5.76      5.47      5.03      5.59      5.25                                                     S.D.   0.09      0.27

  IGL358F         M     5.68      5.58      5.50      5.48      5.53      5.46      5.34      5.36      5.39      5.91      5.86                                   98.21   Mean   5.55      5.30

  IGL358F         F     5.17      5.45      5.50      5.35      5.24      5.27      5.14                                                                                   S.D.   0.19      0.14

  IGL398F         M     4.90      5.19      5.17      5.16      5.48      5.31      5.48      5.38      5.47      5.50                                             83.19   Mean   5.30      5.03

  IGL398F         F     5.27      4.80      5.09      5.28      4.86      4.85                                                                                             S.D.   0.20      0.22

  IGL350F         M     5.93      5.22      5.33      5.48      5.63      5.65      6.02                                                                           85.54   Mean   5.61      5.14

  IGL350F         F     4.97      5.09      5.34      5.45      5.03      4.91      5.20      5.12      5.17                                                               S.D.   0.29      0.17

  IGL353F         M     5.12      4.37      4.75      4.99      5.12      5.00      4.68                                                                           88.78   Mean   4.86      4.56

  IGL353F         F     4.30      4.53      4.44      4.37      4.73      4.69      4.71      4.37      4.88      4.63      4.46      4.64                                 S.D.   0.28      0.18

  IGL420F         M     5.22      5.58      5.64      4.70      5.07      4.89      5.00                                                                           65.33   Mean   5.16      4.87

  IGL420F         F     5.34      4.69      5.03      4.07      5.10      5.00                                                                                             S.D.   0.35      0.44

  IGL435F NP                                                                                                                                                                                

  IGL388F         M     5.45      6.03      5.69                                                                                                                   75.08   Mean   5.72      5.26

  IGL388F         F     5.43      5.48      5.07      4.91      5.35      5.93      5.36      5.51      4.86      5.21      4.80                                           S.D.   0.29      0.34

  IGL413F         M     5.81      5.75      5.36      5.43      5.50      5.58      5.48                                                                           71.36   Mean   5.56      5.41

  IGL413F         F     5.06      5.31      5.57      5.72      5.39      5.40                                                                                             S.D.   0.17      0.23
  --------------- ----- ------ -- ------ -- ------ -- ------ -- ------ -- ------ -- ------ -- ------ -- ------ -- ------ -- ------ -- ------ -- -- -- -- --------- ------- ------ --------- ---------

G-5

  --------------- ----- ------ ------ ------ ------ ------ ------ ------ ------ ------ ------ ------ ------ ------ ------ --------- -------- ------ --------- ---------
  **APPENDIX G -                                                                                                                                              
  FETAL BODY                                                                                                                                                  
  WEIGHT**                                                                                                                                                    

  **(INDIVIDUAL                                                                                                                                               
  AND MEAN FETAL                                                                                                                                              
  BODY WEIGHT AND                                                                                                                                             
  LITTER                                                                                                                                                      
  WEIGHTS)**                                                                                                                                                  

  **(GRAMS)**                                                                                                                                                 

  **TARGET DOSE:                                                                                                                                              
  2000 MG/M^3^**                                                                                                                                              

  ANIMAL                                                                                                                  Litter                    Fetus     
                                                                                                                          Weights                   Weights   

  NUMBER          SEX                                                                                                                               Males     Females

  IGL455F NP                                                                                                                                                  

  IGL414F         M     5.10   5.23   5.18   5.41   5.18   5.26   5.59   5.49                                                       78.53    Mean   5.31      5.16

  IGL414F         F     5.14   5.15   4.98   5.23   4.99   5.30   5.30                                                                       S.D.   0.17      0.13

  IGL433F         M     5.82   6.17   5.49                                                                                          83.29    Mean   5.83      5.06

  IGL433F         F     2.27   5.34   5.34   5.39   5.46   4.42   5.01   5.74   5.55   5.69   4.89   5.16   5.55                             S.D.   0.34      0.91

  IGL441F         M     4.86   5.11   5.48   5.18   5.34   5.32   4.38   5.10                                                       75.04    Mean   5.10      4.90

  IGL441F         F     4.70   4.72   4.51   5.09   5.07   5.25   4.93                                                                       S.D.   0.34      0.26

  IGL457F         M     5.30   5.67   5.32   5.30   5.06   5.60                                                                     63.48    Mean   5.38      5.21

  IGL457F         F     5.23   5.11   5.04   5.32   5.62   4.91                                                                              S.D.   0.22      0.25

  IGL466F         M     5.40   5.51   5.56   5.69   5.75   5.54   5.46   5.48   5.72                                                87.31    Mean   5.57      5.31

  IGL466F         F     5.64   5.34   5.30   5.45   5.06   5.03   5.38                                                                       S.D.   0.12      0.21

  IGL475F         M     6.76   6.68                                                                                                 26.18    Mean   6.72      6.37

  IGL475F         F     6.62   6.12                                                                                                          S.D.   0.06      0.35

  IGL488F         M     5.11   5.59   5.24   5.34                                                                                   41.39    Mean   5.32      5.03

  IGL488F         F     4.99   5.11   4.97   5.04                                                                                            S.D.   0.20      0.06

  IGL432F         M     5.46   5.81   5.46   5.96   5.62   5.46   5.08   5.71   5.30   5.50   5.83                                  103.53   Mean   5.56      5.29

  IGL432F         F     5.37   5.15   5.47   5.40   5.28   5.37   4.98   5.32                                                                S.D.   0.26      0.16

  IGL477F         M     5.85   6.18   6.07   6.26   6.05   5.76                                                                     88.35    Mean   6.03      5.80

  IGL477F         F     5.36   6.02   6.07   5.71   6.11   5.78   5.77   5.75   5.61                                                         S.D.   0.19      0.24

                                                                                                                   Mean             75.98                     

                                                                                                                          S.D.      17.46                     
  --------------- ----- ------ ------ ------ ------ ------ ------ ------ ------ ------ ------ ------ ------ ------ ------ --------- -------- ------ --------- ---------

G-6

  --------------- ----- ------ ------ ------ ------ ------ ------ ------ ------ ------ ------ ------ -- -- -- --------- ------- ------ --------- ---------
  **APPENDIX G -                                                                                                                                 
  FETAL BODY                                                                                                                                     
  WEIGHT**                                                                                                                                       

  **(INDIVIDUAL                                                                                                                                  
  AND MEAN FETAL                                                                                                                                 
  BODY WEIGHT AND                                                                                                                                
  LITTER                                                                                                                                         
  WEIGHTS)**                                                                                                                                     

  **(GRAMS)**                                                                                                                                    

  **TARGET DOSE:                                                                                                                                 
  10,000                                                                                                                                         
  MG/M^3^**                                                                                                                                      

  ANIMAL                                                                                                      Litter                   Fetus     
                                                                                                              Weights                  Weights   

  NUMBER          SEX                                                                                                                  Males     Females

  IGL379F         M     5.53   5.73   5.76   5.92   5.83   5.76   5.64   5.62                                           88.12   Mean   5.72      5.29

  IGL379F         F     5.84   5.33   5.04   5.43   5.24   5.42   5.07   4.96                                                   S.D.   0.12      0.28

  IGL389F         M     6.36   6.13   5.74   6.07   6.17   6.20   6.11   6.07   6.11   6.38                             96.35   Mean   6.13      5.84

  IGL389F         F     5.79   5.79   6.24   5.58   5.69   5.92                                                                 S.D.   0.18      0.23

  IGL391F         M     4.51   5.12   5.34   5.25   4.84   5.11   4.65   5.15                                           72.60   Mean   5.00      4.66

  IGL391F         F     4.66   4.95   4.63   4.84   4.69   4.41   4.45                                                          S.D.   0.30      0.19

  IGL352F         M     5.66   6.09   5.27   6.33   5.57   6.11   6.07                                                  79.89   Mean   5.87      5.54

  IGL352F         F     5.63   5.35   5.47   5.55   5.53   5.75   5.51                                                          S.D.   0.38      0.13

  IGL355F         M     5.41   5.17   4.58   5.24   3.81   4.73   4.93   5.22                                           82.58   Mean   4.89      4.83

  IGL355F         F     4.25   5.13   5.13   4.46   5.25   4.78   4.66   4.67   5.16                                            S.D.   0.52      0.35

  IGL417F         M     5.49   5.15   5.39   5.39   5.61   5.82   5.18   5.26   5.53   5.55   5.58                      86.15   Mean   5.45      5.24

  IGL417F         F     5.29   5.23   5.12   5.29   5.27                                                                        S.D.   0.20      0.07

  IGL378F         M     5.50   5.26   5.21   5.30   5.34   5.51   5.60   5.45                                           68.45   Mean   5.40      5.06

  IGL378F         F     5.19   5.21   4.78   5.19   4.91                                                                        S.D.   0.14      0.20

  IGL380F         M     5.36   5.25   5.23   4.93   5.28   4.93   5.21   4.97   4.74                                    75.68   Mean   5.10      4.96

  IGL380F         F     4.99   4.84   4.95   5.18   4.76   5.06                                                                 S.D.   0.21      0.15

  IGL348F         M     5.13   5.04   5.01   5.44   5.49   5.13   5.59   5.52   5.27   5.18                             72.73   Mean   5.28      4.98

  IGL348F         F     4.94   5.03   5.07   4.89                                                                               S.D.   0.21      0.08

  IGL430F         M     5.75   5.98   5.99                                                                              23.37   Mean   5.91      5.65

  IGL430F         F     5.65                                                                                                    S.D.   0.14      NA

  IGL409F         M     5.28   5.73   5.51                                                                              72.27   Mean   5.51      5.07

  IGL409F         F     4.76   4.86   4.81   5.19   4.91   5.09   5.35   5.36   5.12   5.13   5.17                              S.D.   0.23      0.21

  IGL421F         M     5.93   5.81   5.57   5.48                                                                       66.72   Mean   5.70      5.49

  IGL421F         F     5.22   5.65   5.51   5.66   5.67   5.25   5.76   5.21                                                   S.D.   0.21      0.23

  IGL385F NP                                                                                                                                     

  IGL423F         M     4.74   5.02   5.22   4.99   5.41   4.98   5.13                                                  89.87   Mean   5.07      4.94

  IGL423F         F     4.88   4.89   4.93   5.02   4.74   5.13   5.23   4.97   4.96   4.88   4.75                              S.D.   0.21      0.15

  IGL440F         M     4.48   5.60   5.38   5.73   5.41   5.58   5.68                                                  48.10   Mean   5.41      5.12

  IGL440F         F     4.80   5.44                                                                                             S.D.   0.43      0.45
  --------------- ----- ------ ------ ------ ------ ------ ------ ------ ------ ------ ------ ------ -- -- -- --------- ------- ------ --------- ---------

G-7

  --------------- ----- ------ ------ ------ ------ ------ ------ ------ ------ ------ ------ ------ ------ -- ------ --------- ------- ------ --------- ---------
  **APPENDIX G -                                                                                                                                         
  FETAL BODY                                                                                                                                             
  WEIGHT**                                                                                                                                               

  **(INDIVIDUAL                                                                                                                                          
  AND MEAN FETAL                                                                                                                                         
  BODY WEIGHT AND                                                                                                                                        
  LITTER                                                                                                                                                 
  WEIGHTS)**                                                                                                                                             

  **(GRAMS)**                                                                                                                                            

  **TARGET DOSE:                                                                                                                                         
  10,000                                                                                                                                                 
  MG/M^3^**                                                                                                                                              

  ANIMAL                                                                                                              Litter                   Fetus     
                                                                                                                      Weights                  Weights   

  NUMBER          SEX                                                                                                                          Males     Females

  IGL399F         M     5.72   4.52   5.35   5.28   5.62   5.13   5.48   5.15   5.12   5.53                                     88.98   Mean   5.29      5.15

  IGL399F         F     4.79   5.31   5.07   4.97   5.40   5.53   5.01                                                                  S.D.   0.34      0.26

  IGL452F         M     5.26   5.36   5.38   5.33   5.86   5.48   5.46                                                          73.33   Mean   5.45      5.03

  IGL452F         F     5.25   4.85   5.61   4.95   4.75   5.11   4.68                                                                  S.D.   0.20      0.32

  IGL436F         M     4.72   5.50   5.19   5.64   5.42   5.05   4.09   5.21   4.98   5.10   5.11                              75.86   Mean   5.09      4.96

  IGL436F         F     5.21   5.22   4.70   4.72                                                                                       S.D.   0.42      0.29

  IGL454F         M     4.89   4.86   5.64   5.12                                                                               55.99   Mean   5.13      5.07

  IGL454F         F     5.02   5.56   5.41   4.39   5.02   5.04   5.04                                                                  S.D.   0.36      0.37

  IGL461F         M     6.03   5.80   6.24   5.75   6.38   5.64                                                                 63.51   Mean   5.97      5.53

  IGL461F         F     5.70   5.43   5.67   5.49   5.38                                                                                S.D.   0.29      0.14

  IGL469F         M     6.21                                                                                                    12.51   Mean   6.21      6.30

  IGL469F         F     6.30                                                                                                            S.D.   NA        NA

  IGL470F         M     4.98   5.45   4.86   5.07   5.29   4.76   4.53   4.88   4.79   5.09   5.26   5.15                       88.36   Mean   5.01      4.71

  IGL470F         F     4.36   5.06   4.36   4.85   4.64   4.98                                                                         S.D.   0.26      0.30

  IGL473F         M     5.78   5.62   6.04   5.59   5.35   5.34   5.44                                                          84.09   Mean   5.59      5.62

  IGL473F         F     5.38   5.39   5.60   5.60   6.22   5.94   5.30   5.50                                                           S.D.   0.25      0.31

  IGL407F         M     5.28   5.56   5.07   6.08   5.75   5.83                                                                 86.49   Mean   5.60      5.29

  IGL407F         F     5.48   5.41   5.71   5.10   4.69   4.89   5.00   5.91   5.19   5.54                                             S.D.   0.37      0.38

  IGL442F         M     6.01   5.58   5.55   5.41                                                                               71.11   Mean   5.64      5.40

  IGL442F         F     5.46   5.50   5.39   5.20   5.53   5.57   5.55   5.10   5.26                                                    S.D.   0.26      0.17

                                                                                                               Mean             71.80                    

                                                                                                                      S.D.      20.14                    
  --------------- ----- ------ ------ ------ ------ ------ ------ ------ ------ ------ ------ ------ ------ -- ------ --------- ------- ------ --------- ---------

G-8

  --------------- ----- ------ ------ ------ ------ ------ ------ ------ ------ ------ ------ ------ -- -- -- --------- ------- ------ --------- ---------
  **APPENDIX G -                                                                                                                                 
  FETAL BODY                                                                                                                                     
  WEIGHT**                                                                                                                                       

  **(INDIVIDUAL                                                                                                                                  
  AND MEAN FETAL                                                                                                                                 
  BODY WEIGHT AND                                                                                                                                
  LITTER                                                                                                                                         
  WEIGHTS)**                                                                                                                                     

  **(GRAMS)**                                                                                                                                    

  **TARGET DOSE:                                                                                                                                 
  20,000                                                                                                                                         
  MG/M^3^**                                                                                                                                      

  ANIMAL                                                                                                      Litter                   Fetus     
                                                                                                              Weights                  Weights   

  NUMBER          SEX                                                                                                                  Males     Females

  IGL364F         M     4.95   5.93   5.49   6.05   5.35   5.61   5.60   5.43   5.29   5.51                             90.53   Mean   5.52      5.05

  IGL364F         F     4.97   5.52   5.02   5.41   5.09   5.07   4.24                                                          S.D.   0.31      0.41

  IGL367F         M     5.06   5.19   5.63   5.37   5.46   4.95   5.09   5.18   5.25   5.35   5.30                      77.68   Mean   5.26      4.96

  IGL367F         F     4.79   5.28   4.91   4.87                                                                               S.D.   0.19      0.22

  IGL368F         M     5.33   5.06   5.19   3.18   4.81   5.22   5.25   5.57   5.61   5.94                             81.64   Mean   5.12      5.08

  IGL368F         F     4.85   4.95   5.27   4.94   5.36   5.11                                                                 S.D.   0.75      0.20

  IGL375F         M     5.68   5.62   5.48   5.75   3.44   5.51   5.60   5.48                                           57.78   Mean   5.32      5.07

  IGL375F         F     5.39   5.04   4.79                                                                                      S.D.   0.77      0.30

  IGL363F         M     4.42   6.12   4.93   6.33   5.90                                                                33.30   Mean   5.54      5.60

  IGL363F         F     5.60                                                                                                    S.D.   0.82      NA

  IGL373F         M     5.83   5.34   5.32   5.33                                                                       67.49   Mean   5.46      5.07

  IGL373F         F     5.09   5.07   5.15   4.94   4.64   5.19   4.99   5.31   5.29                                            S.D.   0.25      0.20

  IGL397F         M     5.55   5.51   5.45   5.48   5.48   5.28   6.01   5.76                                           87.30   Mean   5.57      5.35

  IGL397F         F     5.04   5.40   5.53   5.31   5.08   5.51   5.61   5.30                                                   S.D.   0.22      0.21

  IGL357F         M     3.99   4.35   4.41   4.65   4.24   4.57                                                         63.00   Mean   4.37      4.09

  IGL357F         F     1.68   4.23   3.16   4.24   4.71   4.42   4.09   4.54   3.58   3.82                                     S.D.   0.24      0.49

  IGL369F         M     4.17   4.99   5.11   5.41   5.50                                                                70.26   Mean   5.04      5.01

  IGL369F         F     5.31   4.87   5.15   4.81   4.92   4.96   5.29   4.99   4.78                                            S.D.   0.53      0.20

  IGL404F         M     5.76   5.39   5.56   5.33   5.66                                                                75.28   Mean   5.54      5.29

  IGL404F         F     5.42   5.10   5.17   5.60   5.19   5.36   5.19   5.44   5.11                                            S.D.   0.18      0.17

  IGL365F         M     5.40   5.41   5.13   5.98   4.98   5.14   5.62   5.43   5.43                                    78.45   Mean   5.39      4.99

  IGL365F         F     5.09   5.30   4.68   4.81   5.14   4.91                                                                 S.D.   0.30      0.23

  IGL366F         M     5.83   5.46   5.69   6.17   6.04   5.88   5.73   5.45                                           82.10   Mean   5.78      5.12

  IGL366F         F     3.46   5.24   5.16   5.65   5.33   5.37   5.64                                                          S.D.   0.25      0.76

  IGL372F         M     5.09   5.44   5.22   4.95   5.24   5.04   4.93   5.28   5.28   5.51                             76.51   Mean   5.20      4.91

  IGL372F         F     4.49   5.00   5.27   4.75   5.02                                                                        S.D.   0.19      0.30

  IGL396F         M     5.55   5.89   5.39   5.61   5.46   5.52                                                         76.34   Mean   5.57      5.37

  IGL396F         F     5.18   5.48   5.25   5.41   5.18   5.49   5.37   5.56                                                   S.D.   0.17      0.15

  IGL371F         M     5.82   5.96   5.56   5.60   5.95   5.69                                                         79.74   Mean   5.76      5.65

  IGL371F         F     5.08   5.45   5.94   5.88   5.99   5.68   5.49   5.65                                                   S.D.   0.17      0.30
  --------------- ----- ------ ------ ------ ------ ------ ------ ------ ------ ------ ------ ------ -- -- -- --------- ------- ------ --------- ---------

The weight of the first female fetus in litter IGL357 was an outlier and
was not used in the statistical analyses

G-9

  --------------- ----- ------ ------ ------ ------ ------ ------ ------ -- ------ -- ------ -- ------ -- -- -- -- -- -- -- ------ --------- ------- ------ --------- ---------
  **APPENDIX G -                                                                                                                                                      
  FETAL BODY                                                                                                                                                          
  WEIGHT**                                                                                                                                                            

  **(INDIVIDUAL                                                                                                                                                       
  AND MEAN FETAL                                                                                                                                                      
  BODY WEIGHT AND                                                                                                                                                     
  LITTER                                                                                                                                                              
  WEIGHTS)**                                                                                                                                                          

  **(GRAMS)**                                                                                                                                                         

  **TARGET DOSE:                                                                                                                                                      
  20,000                                                                                                                                                              
  MG/M^3^**                                                                                                                                                           

  ANIMAL                                                                                                                           Litter                   Fetus     
                                                                                                                                   Weights                  Weights   

  NUMBER          SEX                                                                                                                                       Males     Females

  IGL410F         M     5.46   5.69   5.48   5.51   5.39   5.28                                                                              77.95   Mean   5.47      5.02

  IGL410F         F     5.30   5.09   4.96   4.78   5.01   4.79   5.21      5.07      4.93                                                           S.D.   0.14      0.17

  IGL415F         M     6.13   6.08   5.99   5.67   6.07   5.82   6.26      5.75      5.88                                                   92.33   Mean   5.96      5.53

  IGL415F         F     5.66   5.49   5.57   5.46   5.50   5.52   5.48                                                                               S.D.   0.19      0.07

  IGL444F         M     5.50   5.49   5.56   6.04   5.64                                                                                     76.36   Mean   5.65      5.35

  IGL444F         F     5.17   5.73   5.25   5.74   5.31   5.05   5.25      5.29      5.34                                                           S.D.   0.23      0.24

  IGL449F         M     6.00   5.58   4.75   6.00   6.08   6.10   5.84                                                                       83.54   Mean   5.76      5.40

  IGL449F         F     4.45   5.39   5.77   5.47   5.69   5.56   5.55      5.31                                                                     S.D.   0.48      0.41

  IGL451F NP                                                                                                                                                          

  IGL458F         M     5.41   5.25   6.14   5.59   5.48   5.76                                                                              74.53   Mean   5.61      5.11

  IGL458F         F     5.37   5.41   5.16   5.23   5.14   5.08   4.91      4.60                                                                     S.D.   0.31      0.26

  IGL471F         M     5.73   5.59   5.96   5.92                                                                                            59.69   Mean   5.80      5.21

  IGL471F         F     5.30   5.41   5.67   5.27   5.39   5.54   3.91                                                                               S.D.   0.17      0.59

  IGL424F         M     5.48   5.68   5.74   5.31   5.36   5.39   5.68      5.53                                                             79.28   Mean   5.52      5.02

  IGL424F         F     4.57   4.93   5.20   5.21   4.80   5.32   5.08                                                                               S.D.   0.16      0.26

  IGL428F         M     5.53   5.31   5.67   4.86   5.90   5.14                                                                              82.42   Mean   5.40      5.00

  IGL428F         F     4.83   5.12   4.64   5.02   5.46   5.22   4.55      5.17      5.08      4.92                                                 S.D.   0.38      0.27

  IGL439F         M     4.91   5.52   4.96   4.95   5.34   4.78   4.74      5.02      5.34                                                   79.19   Mean   5.06      4.80

  IGL439F         F     4.16   4.90   4.61   5.26   4.70   4.86   5.14                                                                               S.D.   0.27      0.36

                                                                                                                            Mean             75.11                    

  NOTE: NP- NOT                                                                                                                    S.D.      12.34                    
  PREGNANT                                                                                                                                                            
  --------------- ----- ------ ------ ------ ------ ------ ------ ------ -- ------ -- ------ -- ------ -- -- -- -- -- -- -- ------ --------- ------- ------ --------- ---------

G-10

  ------------------------------ ----------- ------- -- ----------- -- ----------- -- -----------
  **APPENDIX H - FETAL                                                                
  OBSERVATIONS**                                                                      

  **(INCIDENCE OF FETAL                                                               
  OBSERVATIONS)**                                                                     

                                                                                      

  TARGET DOSE:                   0 MG/M^3^              2000           10,000         20,000
                                                        MG/M^3^        MG/M^3^        MG/M^3^

  TOTAL FETUSES WITH EXTERNAL    0/354                  0/329          0/325          0/343
  VARIATIONS                                                                          

  TOTAL LITTERS WIT\`H EXTERNAL  \[0/25\]               \[0/23\]       \[0/24\]       \[0/24\]
  VARIATIONS                                                                          

                                                                                      

  TOTAL FETUSES WITH EXTERNAL    4/354                  1/329          0/325          0/343
  MALFORMATIONS                                                                       

  TOTAL LITTERS WITH EXTERNAL    \[4/25\]               \[1/23\]       \[0/24\]       \[0/24\]
  MALFORMATIONS                                                                       

                                                                                      

  TOTAL FETUSES WITH VISCERAL    5/178                  2/165          3/162          0/172
  VARIATIONS^a^                                                                       

  TOTAL LITTERS WITH VISCERAL    \[3/25\]               2/23\]         \[2/24\]       \[0/24\]
  VARIATIONS^a^                                                                       

                                                                                      

  TOTAL FETUSES WITH VISCERAL    5/178                  4/165          1/162          2/172
  MALFORMATIONS^a^                                                                    

  TOTAL LITTERS WITH VISCERAL    \[5/25\]               \[4/23\]       \[1/24\]       \[2/24\]
  MALFORMATIONS^a^                                                                    

                                                                                      

  TOTAL FETUSES WITH SKELETAL    39/176                 29/165         42/163         42/171
  VARIATIONS^b^                                                                       

  TOTAL LITTERS WITH SKELETAL    \[17/24\]              \[16/23\]      \[18/24\]      \[18/24\]
  VARIATIONS^b^                                                                       

                                                                                      

  TOTAL FETUSES WITH SKELETAL    1/176                  1/165          1/163          0/171
  MALFORMATIONS                                                                       

  TOTAL LITTERS WITH SKELETAL    \[1/24\]               \[1/23\]       \[1/24\]       \[0/24\]
  MALFORMATIONS                                                                       

                                                                                      

  EXTERNAL EXAMINATIONS                                                               

  \- TOTAL FETUSES EXAMINED:     354                    329            325            343

  \- TOTAL LITTERS EXAMINED:     \[25\]                 \[23\]         \[24\]         \[24\]

                                                                                      

  INDIVIDUAL EXTERNAL                                                                 
  OBSERVATIONS                                                                        

  STUNTED (\<4.0 grams)          4                      1              1              9

                                 \[4\]                  \[1\]          \[1\]          \[5\]

  INDIVIDUAL EXTERNAL                                                                 
  MALFORMATIONS                                                                       

  CONJOINED TWIN                 0                      1              0              0

                                 \[0\]                  \[1\]          \[0\]          \[0\]

                                                                                      

  a -- Includes head                                                                  
  observations                                                                        

  b -- Includes calcaneus                                                             

                                                                                      

                                                                                      

                                                                                      

                                                                                      

                                                                                      

                                                                                      
  ------------------------------ ----------- ------- -- ----------- -- ----------- -- -----------

H-1

  ------------------------------- --------- -- --------- -- --------- -- ---------
  **APPENDIX H - FETAL                                                   
  OBSERVATIONS**                                                         

  **(INCIDENCE OF FETAL                                                  
  OBSERVATIONS)**                                                        

                                                                         

  TARGET DOSE:                    0 MG/M^3^    2000         10,000       20,000
                                               MG/M^3^      MG/M^3^      MG/M^3^

  INDIVIDUAL EXTERNAL                                                    
  MALFORMATIONS (CONT\'D)                                                

  DOMED HEAD                      1            0            0            0

                                  \[1\]        \[0\]        \[0\]        \[0\]

                                                                         

  MALROTATED HIND PAW             2            0            0            0

                                  \[2\]        \[0\]        \[0\]        \[0\]

  VISCERAL EXAMINATIONS                                                  

  \- TOTAL FETUSES EXAMINED:      177          165          162          172

  \- TOTAL LITTERS EXAMINED:      \[25\]       \[23\]       \[24\]       \[24\]

                                                                         

  INDIVIDUAL VISCERAL VARIATIONS                                         

  MISSHAPEN SPLEEN                0            1            0            0

                                  \[0\]        \[1\]        \[0\]        \[0\]

                                                                         

  UMBILICAL ARTERY ARISES FROM    4            1            3            0
  LEFT SIDE OF                                                           

  URINARY BLADDER                 \[3\]        \[1\]        \[2\]        \[0\]

                                                                         

  INDIVIDUAL VISCERAL                                                    
  MALFORMATIONS                                                          

  ATRIAL CHAMBER LARGE            0            1            0            0

                                  \[0\]        \[1\]        \[0\]        \[0\]

                                                                         

  CECUM NOT EVIDENT               0            1            0            0

                                  \[0\]        \[1\]        \[0\]        \[0\]

                                                                         

  DOUBLE AORTA                    0            1            0            0

                                  \[0\]        \[1\]        \[0\]        \[0\]

                                                                         

                                                                         

                                                                         

                                                                         

                                                                         

                                                                         

                                                                         

                                                                         
  ------------------------------- --------- -- --------- -- --------- -- ---------

H-2

  ------------------------------- --------- -- --------- -- --------- -- ---------
  **APPENDIX H - FETAL                                                   
  OBSERVATIONS**                                                         

  **(INCIDENCE OF FETAL                                                  
  OBSERVATIONS)**                                                        

                                                                         

  TARGET DOSE:                    0 MG/M^3^    2000         10,000       20,000
                                               MG/M^3^      MG/M^3^      MG/M^3^

  INDIVIDUAL VISCERAL                                                    
  MALFORMATIONS (CONT\'D)                                                

  DUPLICATE TONGUE                0            1            0            0

                                  \[0\]        \[1\]        \[0\]        \[0\]

                                                                         

  INNOMINATE ELONGATED            0            1            0            0

                                  \[0\]        \[1\]        \[0\]        \[0\]

                                                                         

  INNOMINATE ABSENT               1            0            0            0

                                  \[1\]        \[0\]        \[0\]        \[0\]

                                                                         

  HYDRONEPHROSIS                  2            1            0            0

                                  \[2\]        \[1\]        \[0\]        \[0\]

                                                                         

  HYDROURETER                     2            1            0            0

                                  \[2\]        \[1\]        \[0\]        \[0\]

                                                                         

  LUNG SUPERNUMERARY LOBE         0            1            0            0

                                  \[0\]        \[1\]        \[0\]        \[0\]

                                                                         

  MALPOSITIONED CAROTID ARTERY    1            1            0            0

                                  \[1\]        \[1\]        \[0\]        \[0\]

                                                                         

  MALPOSITIONED SUBCLAVIAN ARTERY 1            1            0            0

                                  \[1\]        \[1\]        \[0\]        \[0\]

                                                                         

  MALPOSITIONED PULMONARY ARTERY  0            1            0            0

                                  \[0\]        \[1\]        \[0\]        \[0\]

                                                                         

                                                                         

                                                                         

                                                                         

                                                                         

                                                                         

                                                                         

                                                                         

                                                                         
  ------------------------------- --------- -- --------- -- --------- -- ---------

H-3

  ------------------------------- --------- -- --------- -- --------- -- ---------
  **APPENDIX H - FETAL                                                   
  OBSERVATIONS**                                                         

  **(INCIDENCE OF FETAL                                                  
  OBSERVATIONS)**                                                        

                                                                         

  TARGET DOSE:                    0 MG/M^3^    2000         10,000       20,000
                                               MG/M^3^      MG/M^3^      MG/M^3^

  INDIVIDUAL VISCERAL                                                    
  MALFORMATIONS (CONT\'D)                                                

  OPEN EYE                        0            0            0            1

                                  \[0\]        \[0\]        \[0\]        \[1\]

                                                                         

  RETINA FOLD                     1            0            1            0

                                  \[1\]        \[0\]        \[1\]        \[0\]

                                                                         

  SHARED ORGANS                   0            1            0            0

                                  \[0\]        \[1\]        \[0\]        \[0\]

                                                                         

  SPLEEN SMALL                    0            1            0            0

                                  \[0\]        \[1\]        \[0\]        \[0\]

                                                                         

  UMBILICAL ARTERY ANEURYSM       0            0            0            1

                                  \[0\]        \[0\]        \[0\]        \[1\]

                                                                         

  VENTRICLE SMALL                 0            1            0            0

                                  \[0\]        \[1\]        \[0\]        \[0\]

  SKELETAL EXAMINATIONS                                                  

  \- TOTAL FETUSES EXAMINED:      176          165          163          171

  \- TOTAL LITTERS EXAMINED:      \[24\]       \[23\]       \[24\]       \[24\]

                                                                         

  INDIVIDUAL OSSIFICATION                                                
  OBSERVATIONS                                                           

  CALCANEUS ADVANCED              1            0            0            0

                                  \[1\]        \[0\]        \[0\]        \[0\]

                                                                         

                                                                         

                                                                         

                                                                         

                                                                         

                                                                         

                                                                         

                                                                         

                                                                         
  ------------------------------- --------- -- --------- -- --------- -- ---------

H-4

  ------------------------------- --------- -- --------- -- --------- -- ---------
  **APPENDIX H - FETAL                                                   
  OBSERVATIONS**                                                         

  **(INCIDENCE OF FETAL                                                  
  OBSERVATIONS)**                                                        

                                                                         

  TARGET DOSE:                    0 MG/M^3^    2000         10,000       20,000
                                               MG/M^3^      MG/M^3^      MG/M^3^

  INDIVIDUAL OSSIFICATION                                                
  VARIATIONS                                                             

  SKULL                                                                  

  HYPOPLASTIC                     0            1            1            0

                                  \[0\]        \[1\]        \[1\]        \[0\]

                                                                         

  MISSHAPEN                       0            1            0            0

                                  \[0\]        \[1\]        \[0\]        \[0\]

  STERNEBRAE                                                             

  ADVANCED                        1            2            2            0

                                  \[1\]        \[2\]        \[1\]        \[0\]

                                                                         

  ASYMMETRIC                      0            2            1            2

                                  \[0\]        \[2\]        \[1\]        \[1\]

                                                                         

  BIFID                           0            1            0            1

                                  \[0\]        \[1\]        \[0\]        \[1\]

                                                                         

  DUMBBELL SHAPED                 0            0            0            3

                                  \[0\]        \[0\]        \[0\]        \[1\]

                                                                         

  HYPOPLASTIC                     0            0            1            1

                                  \[0\]        \[0\]        \[1\]        \[1\]

                                                                         

  MISSHAPEN                       4            6            2            5

                                  \[3\]        \[4\]        \[2\]        \[5\]

                                                                         

  UNOSSIFIED                      3            0            5            10

                                  \[3\]        \[0\]        \[3\]        \[6\]

                                                                         
  ------------------------------- --------- -- --------- -- --------- -- ---------

H-5

  ------------------------------- --------- -- --------- -- --------- -- ---------
  **APPENDIX H - FETAL                                                   
  OBSERVATIONS**                                                         

  **(INCIDENCE OF FETAL                                                  
  OBSERVATIONS)**                                                        

                                                                         

  TARGET DOSE:                    0 MG/M^3^    2000         10,000       20,000
                                               MG/M^3^      MG/M^3^      MG/M^3^

  INDIVIDUAL OSSIFICATION                                                
  VARIATIONS (CONT\'D)                                                   

  FOREPAW                                                                

  UNOSSIFIED                      1            0            0            0

                                  \[1\]        \[0\]        \[0\]        \[0\]

  RIBS                                                                   

  CERVICAL                        1            0            0            0

                                  \[1\]        \[0\]        \[0\]        \[0\]

                                                                         

  SHORT LAST THORACIC             2            0            1            0

                                  \[2\]        \[0\]        \[1\]        \[0\]

                                                                         

  RUDIMENTARY LUMBAR              17           15           23           24

                                  \[9\]        \[10\]       \[13\]       \[13\]

                                                                         

  WELL-FORMED LUMBAR              0            0            0            1

                                  \[0\]        \[0\]        \[0\]        \[1\]

  VERTEBRAE                                                              

  CENTRA BIFID                    7            6            6            5

                                  \[6\]        \[6\]        \[3\]        \[5\]

                                                                         

  DUMBBELL-SHAPED CENTRA          3            1            3            2

                                  \[3\]        \[1\]        \[2\]        \[2\]

                                                                         

  CENTRA MISSHAPEN                0            0            1            0

                                  \[0\]        \[0\]        \[1\]        \[0\]

                                                                         

  CENTRA UNOSSIFIED               0            1            0            0

                                  \[0\]        \[1\]        \[0\]        \[0\]

                                                                         
  ------------------------------- --------- -- --------- -- --------- -- ---------

H-6

  ------------------------------- -- --------- -- -- -- --------- -- --------- -- ---------
  **APPENDIX H - FETAL                                                            
  OBSERVATIONS**                                                                  

  **(INCIDENCE OF FETAL                                                           
  OBSERVATIONS)**                                                                 

                                                                                  

  TARGET DOSE:                       0 MG/M^3^          2000         10,000       20,000
                                                        MG/M^3^      MG/M^3^      MG/M^3^

  INDIVIDUAL OSSIFICATION                                                         
  VARIATIONS (CONT\'D)                                                            

  VERTEBRAE (CONT\'D)                                                             

  LUMBAR CENTRA DUMBBELL SHAPED      1                  1            1            0

                                     \[1\]              \[1\]        \[1\]        \[0\]

  INDIVIDUAL CARTILAGINOUS                                                        
  STRUCTURAL VARIATIONS                                                           

  FOREPAW ANLAGE                                                                  

  MISSHAPEN                          0                  0            1            0

                                     \[0\]              \[0\]        \[1\]        \[0\]

  RIB ANLAGE                                                                      

  SUPERNUMERARY CERVICAL RIB         1                  0            0            0

                                     \[1\]              \[0\]        \[0\]        \[0\]

  VERTEBRAE ANLAGE                                                                

  CERVICAL CENTRA BIFID              0                  0            0            1

                                     \[0\]              \[0\]        \[0\]        \[1\]

                                                                                  

  THORACIC CENTRA DUMBBELL SHAPED    12                 4            9            3

                                     \[8\]              \[4\]        \[5\]        \[3\]

  INDIVIDUAL OSSIFICATION                                                         
  MALFORMATIONS                                                                   

  SKULL                                                                           

  DUPLICATE BONES                    0                  1            0            0

                                     \[0\]              \[1\]        \[0\]        \[0\]

  PECTORAL GIRDLE                                                                 

  CLAVICLE FUSED BETWEEN TWINS       0                  1            0            0

                                     \[0\]              \[1\]        \[0\]        \[0\]

                                                                                  

  DUPLICATE BONES                    0                  1            0            0

                                     \[0\]              \[1\]        \[0\]        \[0\]

                                                                                  

                                                                                  

                                                                                  

                                                                                  

                                                                                  

                                                                                  

                                                                                  

                                                                                  
  ------------------------------- -- --------- -- -- -- --------- -- --------- -- ---------

H-7

  ------------------------------- -- --------- -- -- -- --------- -- --------- -- ---------
  **APPENDIX H - FETAL                                                            
  OBSERVATIONS**                                                                  

  **(INCIDENCE OF FETAL                                                           
  OBSERVATIONS)**                                                                 

                                                                                  

  TARGET DOSE:                       0 MG/M^3^          2000         10,000       20,000
                                                        MG/M^3^      MG/M^3^      MG/M^3^

  INDIVIDUAL OSSIFICATION                                                         
  MALFORMATIONS (CONT\'D)                                                         

  STERNEBRAE                                                                      

  DUPLICATE BONES                    0                  1            0            0

                                     \[0\]              \[1\]        \[0\]        \[0\]

  FORELIMB                                                                        

  DUPLICATE BONES                    0                  1            0            0

                                     \[0\]              \[1\]        \[0\]        \[0\]

                                                                                  

  FOREPAW                                                                         

  DUPLICATE BONES                    0                  1            0            0

                                     \[0\]              \[1\]        \[0\]        \[0\]

                                                                                  

  RIBS                                                                            

  FUSED BETWEEN TWINS                0                  1            0            0

                                     \[0\]              \[1\]        \[0\]        \[0\]

                                                                                  

  DUPLICATE BONES                    0                  1            0            0

                                     \[0\]              \[1\]        \[0\]        \[0\]

  VERTEBRAE                                                                       

  DUPLICATE BONES                    0                  1            0            0

                                     \[0\]              \[1\]        \[0\]        \[0\]

                                                                                  

  CERVICAL CENTRA FUSED              0                  1            0            0

                                     \[0\]              \[1\]        \[0\]        \[0\]

                                                                                  

  THORACIC CENTRA HEMICENTRA         0                  1            0            0

                                     \[0\]              \[1\]        \[0\]        \[0\]

                                                                                  
  ------------------------------- -- --------- -- -- -- --------- -- --------- -- ---------

H-8

  ------------------------------- --------- -- --------- -- --------- -- ---------
  **APPENDIX H - FETAL                                                   
  OBSERVATIONS**                                                         

  **(INCIDENCE OF FETAL                                                  
  OBSERVATIONS)**                                                        

                                                                         

  TARGET DOSE:                    0 MG/M^3^    2000         10,000       20,000
                                               MG/M^3^      MG/M^3^      MG/M^3^

  INDIVIDUAL OSSIFICATION                                                
  MALFORMATIONS (CONT\'D)                                                

  VERTEBRAE (CONT\'D)                                                    

  THORACIC ONE LESS PRESACRAL     0            0            1            0

                                  \[0\]        \[0\]        \[1\]        \[0\]

  PELVIC GIRDLE                                                          

  DUPLICATE BONES                 0            1            0            0

                                  \[0\]        \[1\]        \[0\]        \[0\]

  HINDLIMB                                                               

  DUPLICATE BONES                 0            1            0            0

                                  \[0\]        \[1\]        \[0\]        \[0\]

  HINDPAW                                                                

  DUPLICATE BONES                 0            1            0            0

                                  \[0\]        \[1\]        \[0\]        \[0\]

  INDIVIDUAL CARTILAGINOUS                                               
  MALFORMATIONS                                                          

  RIB ANLAGE                                                             

  FUSED                           1            0            0            0

                                  \[1\]        \[0\]        \[0\]        \[0\]

                                                                         

                                                                         
  ------------------------------- --------- -- --------- -- --------- -- ---------

H-9

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 0 MG/M3

> ANIMAL NUMBER: IGL359F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 2 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A M + + +
>
> 2 A M + +
>
> 3 A M + + +
>
> 4 A M + (c,d)
>
> 5 A F + + +
>
> 6 A F + +
>
> 7 A F + + +
>
> 8C A M + (a,b,e)
>
> 9 A F + + +
>
> 10 A F + +
>
> 11 A F + + +
>
> 12 A M + +
>
> 13 A F + + +
>
> 14 A M + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/STERNEBRAE (V): Unossified
>
> \(b\) - SKELETAL/RIBS (T13): Short last rib; Right
>
> \(c\) - SKELETAL/VERTEBRAE (T11-12): Bifid centra
>
> \(d\) - SKELETAL/VERTEBRAE (T11-12 Anlage): Dumbbell shaped centra
>
> \(e\) - SKELETAL/VERTEBRAE (T9): Dumbbell shaped centra

H-10

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 0 MG/M3

> ANIMAL NUMBER: IGL360F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 3 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A M + (b,c)
>
> 2 A F + + +
>
> 3 A F + (b,c)
>
> 4 A F + + +
>
> 5 A F + +
>
> 6 A F + + +
>
> 7 A F + +
>
> 8C A F + + +
>
> 9 A M + +
>
> 10 A M + + +
>
> 11 A M + +
>
> 12 A F + + +
>
> 13 A M + +
>
> E
>
> 14 A F + + +
>
> 15 A F + (a)
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/RIBS (L1): Rudimentary; Left
>
> \(b\) - SKELETAL/VERTEBRAE (T10-11): Bifid centra
>
> \(c\) - SKELETAL/VERTEBRAE (T10-11 Anlage): Dumbbell shaped centra

H-11

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 0 MG/M3

> ANIMAL NUMBER: IGL370F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 2 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + +
>
> 2 A M + + +
>
> 3 A M + +
>
> 4 A F + + +
>
> 5 A M + +
>
> 6 A M + + +
>
> 7 A M + +
>
> 8 A M + + +
>
> 9C A F + (n)
>
> 10 A F + + +
>
> 11 A F + +
>
> 12 A M + + +
>
> 13\* D M (A,B,C,D,E,F,G) (H,i) (J,K,L,M)
>
> 14 A F + + +
>
> 15 A M + (o)
>
> 16 A F + + +
>
> 17 A M + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \* - Stunted
>
> \(A\) - EXTERNAL: Kyphosis (L) - ABDOMEN/THORAX: Malpositioned ovaries
>
> \(B\) - EXTERNAL: Ectrodactyly; all paws (M) - ABDOMEN/THORAX: No
> cervical spinal column
>
> \(C\) - EXTERNAL: Brachydactyly; all paws (n) - SKELETAL/RIBS (L1):
> Rudimentary; Right
>
> \(D\) - EXTERNAL: Acaudate (o) - SKELETAL/RIBS (L1): Rudimentary; Left
>
> \(E\) - EXTERNAL: Anal atresia
>
> \(F\) - EXTERNAL: Anasarca
>
> \(G\) - EXTERNAL: Small eye bulge; Bilateral
>
> \(H\) - HEAD: Anophthalmia; Bilateral
>
> \(i\) - HEAD: Dilated lateral ventricles; Bilateral
>
> \(J\) - ABDOMEN/THORAX: Malpositioned uterus
>
> \(K\) - ABDOMEN/THORAX: Malpositioned kidneys

H-12

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 0 MG/M3

> ANIMAL NUMBER: IGL374F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 1
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 2 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + (b,c)
>
> 2 A M + (A) +
>
> 3 A F + +
>
> 4 A M + + +
>
> 5 A F + +
>
> 6C A M + + +
>
> 7 A F + (d)
>
> 8 A M + + +
>
> 9 A F + +
>
> E
>
> 10 A M + + +
>
> 11 A F + +
>
> 12 A M + + +
>
> 13 A F + +
>
> 14 A M + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(A\) - HEAD: Retinal fold; Left
>
> \(b\) - SKELETAL/VERTEBRAE (T11): Bifid centra
>
> \(c\) - SKELETAL/VERTEBRAE (T11 Anlage): Dumbbell shaped centra
>
> \(d\) - SKELETAL/VERTEBRAE (T9): Dumbbell shaped centra

H-13

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 0 MG/M3

> ANIMAL NUMBER: IGL395F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 2 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A M + + +
>
> 2 A M + +
>
> 3 A M + + +
>
> 4 A M + +
>
> 5 A M + + +
>
> 6 A F + +
>
> 7 A M + + +
>
> 8C A F + +
>
> 9 A F + + +
>
> 10 A M + (a)
>
> 11 A M + + +
>
> 12 A M + +
>
> 13 A M + + +
>
> 14 A M + +
>
> 15 A F + + +
>
> 16 A M + (b)
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE: Fetus numbers 4 and 6 assigned randomly.
>
> \(a\) - SKELETAL/VERTEBRAE (T11-12 Anlage): Dumbbell shaped centra
>
> \(b\) - SKELETAL/VERTEBRAE (T11 Anlage): Dumbbell shaped centra

H-14

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 0 MG/M3

> ANIMAL NUMBER: IGL383F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 1 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 0 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + + +
>
> 2 A F + +
>
> 3 A M + + (a)
>
> 4 A M + +
>
> 5C A M + + +
>
> 6 A F + +
>
> 7 A F + + +
>
> 8 A M + +
>
> 9 A F + + +
>
> 10 A M + +
>
> 11 A F + + +
>
> 12 A M + +
>
> 13 A M + + +
>
> 14 A M + +
>
> 15 A M + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - ABDOMEN/THORAX: Umbilical artery arises from left side of
> urinary bladder

H-15

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 0 MG/M3

> ANIMAL NUMBER: IGL386F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 2 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A M + +
>
> 2 A F + + +
>
> 3 A M + (b,c)
>
> 4 A M + + +
>
> 5 A M + +
>
> 6C A M + + +
>
> 7 A M + +
>
> 8 A F + + +
>
> 9 A M + +
>
> 10 A F + + +
>
> 11 A F + +
>
> 12 A M + + +
>
> 13 A M + (a)
>
> 14 A M + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/STERNEBRAE (VI): Advanced
>
> \(b\) - SKELETAL/VERTEBRAE (T12): Bifid centra
>
> \(c\) - SKELETAL/VERTEBRAE (T12 Anlage): Dumbbell shaped centra

H-16

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 0 MG/M3

> ANIMAL NUMBER: IGL394
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 1
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 2 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + +(\*)
>
> 2 A F + + +
>
> 3 A M + +
>
> 4 A M + + +
>
> 5 A M + +
>
> 6C A M (A) + +
>
> 7 A M + +
>
> 8 A F + + +
>
> 9 A M + +
>
> 10 A F + + +
>
> 11 A F + (b)
>
> 12 A F + + +
>
> 13 A F + +
>
> 14 A F + + +
>
> 15 A F + (b)
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(A\) - EXTERNAL: Malrotated hindpaw; Left
>
> \(b\) - SKELETAL/STERNEBRAE (VI): Misshapen
>
> (\*) - SKELETAL/HINDPAW (Calcaneus): Advanced; Bilateral

H-17

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 0 MG/M3

> ANIMAL NUMBER: IGL402F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 1
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 4 MALFORMATIONS: 1
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + +
>
> 2 A M + + +
>
> 3 A F + +
>
> 4 A M + + +
>
> 5 A F + +
>
> 6 A F + + +
>
> 7C A M + (h)
>
> 8 A F + + +
>
> 9 A M + (e)
>
> 10 A M + + +
>
> 11 A F + +
>
> 12 A M + + +
>
> 13\* A M (A) (b,c,f,G,i)
>
> 14 A F + + +
>
> 15 A F + +
>
> 16 A F + + +
>
> 17 A F + (d,h)
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \* - Stunted
>
> \(A\) - EXTERNAL: Domed head
>
> \(b\) - SKELETAL/FOREPAW (Proximal phalanges 2-4): Unossified;
> Bilateral
>
> \(c\) - SKELETAL/STERNEBRAE (IV-V): Unossified
>
> \(d\) - SKELETAL/STERNEBRAE (VI): Misshapen
>
> \(e\) - SKELETAL/RIBS (L1): Rudimentary; Bilateral
>
> \(f\) - SKELETAL/RIBS (C7, C7 Anlage): Cervical rib; Bilateral
>
> \(G\) - SKELETAL/RIBS (C7 and T1 Anlage): Fused; Anlage on C7 and T1
> rib fused before it meets sternebrae
>
> \(h\) - SKELETAL/VERTEBRAE (T12 Anlage): Dumbbell shaped centra
>
> \(i\) - SKELETAL/VERTEBRAE (T10 Anlage): Dumbbell shaped centra

H-18

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 0 MG/M3

> ANIMAL NUMBER: IGL411F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 2 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + + +
>
> 2 A F + +
>
> 3 A F + + +
>
> 4 A F + +
>
> 5 A F + + +
>
> 6 A F + (b)
>
> 7 A F + + +
>
> E
>
> 8 A M + +
>
> 9C A F + + +
>
> 10 A F + (a)
>
> 11 A M + + +
>
> 12 A M + +
>
> 13 A M + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/STERNEBRAE (VI): Misshapen
>
> \(b\) - SKELETAL/RIBS (L1): Rudimentary; Right

H-19

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 0 MG/M3

> ANIMAL NUMBER: IGL422F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 2 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A M + +
>
> 2 A F + + +
>
> 3 A M + +
>
> 4 A F + + +
>
> 5 A F + (b)
>
> 6 A F + + +
>
> 7 A F + (a)
>
> 8 A M + + +
>
> 9C A F + +
>
> 10 A M + + +
>
> 11 A M + +
>
> 12 A F + + +
>
> 13 A M + +
>
> 14 A M + + +
>
> 15 A M + +
>
> 16 A M + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/RIBS (T13): Short last rib; Right
>
> \(b\) - SKELETAL/VERTEBRAE (T12 Anlage): Dumbbell shaped centra

H-20

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 0 MG/M3

> ANIMAL NUMBER: IGL347F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 2 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + + +
>
> 2 A F + +
>
> 3 A M + + +
>
> 4 A F + +
>
> 5 A M + + +
>
> 6 A F + (a)
>
> 7 A M + + +
>
> 8 A F + (a)
>
> 9C A F + + +
>
> 10 A M + +
>
> 11 A F + + +
>
> 12 A M + +
>
> 13 A F + + +
>
> 14 A M + +
>
> 15 A F + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:

(a) \- SKELETAL/RIBS (L1): Rudimentary; Left

H-21

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 0 MG/M3

> ANIMAL NUMBER: IGL427F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 0 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> E
>
> 1C A F + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES

H-22

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 0 MG/M3

> ANIMAL NUMBER: IGL400F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 3 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + +
>
> 2 A F + + +
>
> 3 A F + +
>
> 4 A M + + +
>
> 5 A F + (a)
>
> 6 A F + + +
>
> 7 A F + (a)
>
> 8 A M + + +
>
> 9 A F + (b)
>
> 10 A M + + +
>
> 11C A M + +
>
> 12 A M + + +
>
> 13 A M + +
>
> 14 A M + + +
>
> 15 A F + +
>
> 16 A M + + +
>
> 17 A F + +
>
> 18 A M + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/RIBS (L1): Rudimentary; Bilateral
>
> \(b\) - SKELETAL/VERTEBRAE (T10): Bifid centra

H-23

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 0 MG/M3

> ANIMAL NUMBER: IGL408F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 1 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 0 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + +
>
> 2 A F + + +
>
> 3 A M + +
>
> 4 A M + + +
>
> 5 A M + +
>
> 6 A M + + +
>
> 7 A M + +
>
> 8 A F + + +
>
> 9 A M + +
>
> 10C A F + + +
>
> 11 A F + +
>
> 12 A F + + +
>
> 13 A F + +
>
> 14 A F + + (a)
>
> 15 A F + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:

(a) \- ABDOMEN/THORAX: Umbilical artery arises from left side of urinary
    bladder

H-24

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 0 MG/M3

> ANIMAL NUMBER: IGL393F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 0 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + + +
>
> 2 A F + +
>
> 3 A M + + +
>
> 4C A M + +
>
> 5 A F + + +
>
> 6 A M + +
>
> 7 A M + + +
>
> 8 A F + +
>
> 9 A F + + +
>
> 10 A M + +
>
> 11 A M + + +
>
> 12 A F + +
>
> 13 A F + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES

H-25

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 0 MG/M3

> ANIMAL NUMBER: IGL419F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 1 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + + +
>
> 2 A M + +
>
> 3 A F + + +
>
> 4 A M + +
>
> 5 A F + + +
>
> 6C A F + +
>
> 7 A F + + +
>
> 8 A F + +
>
> 9 A F + + +
>
> 10 A F + +
>
> 11 A M + + +
>
> 12 A F + (a,b)
>
> 13 A M + + +
>
> 14 A F + +
>
> 15 A M + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/VERTEBRAE (T11): Bifid centra
>
> \(b\) - SKELETAL/VERTEBRAE (T11 Anlage): Dumbbell shaped centra

H-26

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 0 MG/M3

> ANIMAL NUMBER: IGL434F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 1
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 0 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + +
>
> 2 A M + + +
>
> 3 A M + +
>
> 4 A M + + +
>
> 5 A M + +
>
> 6 A M + + +
>
> 7 A M + +
>
> 8 A M + + +
>
> 9 A F + +
>
> 10C A M + + +
>
> 11 A M + +
>
> 12 A M + + (A,B)
>
> 13 A F + +
>
> L
>
> 14 A F + + +
>
> 15 A F + +
>
> 16 A F + + +
>
> 17 A M + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(A\) - ABDOMEN/THORAX: Hydroureter; Bilateral
>
> \(B\) - ABDOMEN/THORAX: Hydronephrosis; Bilateral

H-27

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 0 MG/M3

> ANIMAL NUMBER: IGL445F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 0 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + + +
>
> 2 A M + +
>
> 3 A M + + +
>
> 4 A M + +
>
> 5\* A M + + +
>
> 6C A M + +
>
> 7 A M + + +
>
> 8 A M + +
>
> 9 A F + + +
>
> 10 A F + +
>
> 11 A F + + +
>
> 12 A F + +
>
> 13 A F + + +
>
> 14 A F + +
>
> 15 A F + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \* - Stunted

H-28

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 0 MG/M3

> ANIMAL NUMBER: IGL446F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 2 MALFORMATIONS: 1
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 1 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A M + +
>
> 2 A F + + +
>
> 3 A M + +
>
> 4 A F + + (a,B,C)
>
> 5 A M + +
>
> 6 A M + + +
>
> E
>
> 7 A F + +
>
> 8C A M + + (a)
>
> 9 A F + +
>
> 10 A M + + +
>
> 11 A F + (d)
>
> 12 A F + + +
>
> E
>
> 13 A M + +
>
> 14 A F + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - ABDOMEN/THORAX: Umbilical artery arises from left side of
> urinary bladder
>
> \(B\) - ABDOMEN/THORAX: Hydroureter; Left
>
> \(C\) - ABDOMEN/THORAX: Hydronephrosis; Left
>
> \(d\) - SKELETAL/STERNEBRAE (V): Unossified

H-29

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 0 MG/M3

> ANIMAL NUMBER: IGL465F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 1
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 0 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + + +
>
> 2 A F + +
>
> 3 A F + + +
>
> 4 A F + +
>
> 5 A M + + +
>
> 6 A M + +
>
> 7 A F + + +
>
> 8C A F (A) +
>
> 9 A M + + +
>
> 10 A F + +
>
> 11 A F + + +
>
> 12 A M + +
>
> 13 A M + + +
>
> 14 A M + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:

(A) \- EXTERNAL: Malrotated hind paw; Left

H-30

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 0 MG/M3

> ANIMAL NUMBER: IGL490F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 1
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 3 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + +
>
> 2 A M + + +
>
> 3 A M + (e)
>
> 4 A F + + +
>
> 5 A M + (e)
>
> 6 A F + + +
>
> 7 A M + +
>
> 8\* A F + + (A,B,C,D)
>
> 9C A F + +
>
> 10 A F + + +
>
> 11 A M + (e)
>
> 12 A M + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \* - Stunted
>
> \(A\) - ABDOMEN/THORAX: Innominate artery absent
>
> \(B\) - ABDOMEN/THORAX: Malpositioned carotid branch; Left
>
> \(C\) - ABDOMEN/THORAX: Malpositioned carotid branch; Right
>
> \(D\) - ABDOMEN/THORAX: Malpositioned subclavian branch; Right
>
> \(e\) - SKELETAL/RIBS (L1): Rudimentary; Left

H-31

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 0 MG/M3

> ANIMAL NUMBER: IGL406F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 0 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A M + +
>
> 2 A F + + +
>
> 3 A F + +
>
> 4 A F + + +
>
> 5C A M + +
>
> 6 A M + + +
>
> 7 A M + +
>
> 8 A M + + +
>
> 9 A M + +
>
> E
>
> 10 A F + + +
>
> 11 A F + +
>
> 12 A F + + +
>
> 13 A M + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES

H-32

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 0 MG/M3

> ANIMAL NUMBER: IGL418F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 4 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + (a)
>
> 2 A F + + +
>
> 3 A F + (b,d)
>
> E
>
> 4 A F + + +
>
> 5 A M + (c)
>
> 6C A M + + +
>
> 7 A F + +
>
> 8 A M + + +
>
> 9 A M + (a)
>
> 10 A M + + +
>
> 11 A F + +
>
> 12 A M + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/RIBS (L1): Rudimentary; Bilateral
>
> \(b\) - SKELETAL/RIBS (L1): Rudimentary; Left
>
> \(c\) - SKELETAL/RIBS (L1): Rudimentary; Right
>
> \(d\) - SKELETAL/VERTEBRAE (L1): Dumbbell shaped centra; Left

H-33

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 0 MG/M3

> ANIMAL NUMBER: IGL474F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 1 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + +
>
> 2 A F + + +
>
> 3 A F + (a)
>
> 4 A F + + +
>
> 5 A F + +
>
> E
>
> 6C A F + + +
>
> 7 A M + +
>
> 8 A M + + +
>
> 9 A M + +
>
> 10 A F + + +
>
> 11 A F + +
>
> 12 A M + + +
>
> 13 A M + +
>
> 14 A F + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:

(a) \- SKELETAL/RIBS (L1): Rudimentary; Left

H-34

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 2000 MG/M3

> ANIMAL NUMBER: IGL346F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 0 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A M + +
>
> 2 A M + + +
>
> 3 A M + +
>
> 4 A F + + +
>
> 5 A F + +
>
> 6 A F + + +
>
> 7C A M + +
>
> 8 A F + + +
>
> 9 A F + +
>
> 10 A M + + +
>
> 11 A F + +
>
> 12 A M + + +
>
> 13 A M + +
>
> 14 A F + + +
>
> 15 A F + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES

H-35

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 2000 MG/M3

> ANIMAL NUMBER: IGL361F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 1 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A M + + +
>
> 2 A F + +
>
> 3 A F + + +
>
> 4 A F + +
>
> 5 A M + + +
>
> 6C A F + +
>
> 7 A F + + +
>
> 8 A M + (a,b)
>
> 9 A F + + +
>
> 10 A M + +
>
> 11 A M + + +
>
> 12 A F + +
>
> 13 A M + + +
>
> 14 A M + +
>
> 15 A F + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/STERNEBRAE (VI): Advanced
>
> \(b\) - SKELETAL/RIBS (L1): Rudimentary; Left

H-36

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 2000 MG/M3

> ANIMAL NUMBER: IGL376F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 1 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 0 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A M + +
>
> 2 A F + + (a)
>
> 3 A M + +
>
> 4 A F + + +
>
> 5 A F + +
>
> 6 A F + + +
>
> 7 A M + +
>
> 8C A M + + +
>
> 9 A F + +
>
> 10 A M + + +
>
> 11 A F + +
>
> 12 A M + + +
>
> 13 A M + +
>
> E
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - ABDOMEN/THORAX: Umbilical artery arises from left side of
> urinary bladder

H-37

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 2000 MG/M3

> ANIMAL NUMBER: IGL381F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 1 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> E
>
> 1 A F + +
>
> 2 A M + + +
>
> 3 A M + + +
>
> 4 A F + +
>
> 5 A F + + +
>
> E
>
> 6 A M + (a,b)
>
> E
>
> 7 A F + + +
>
> 8 A F + +
>
> 9C A M + + +
>
> E
>
> 10 A F + +
>
> E
>
> 11 A F + + +
>
> E
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE: Fetus \# 1 inadvertently eviscerated, therefore fetus \# 1
> received a skeletal exam and fetus \# 2 received a visceral and head
> exam.
>
> \(a\) - SKELETAL/VERTEBRAE (T10): Bifid centra
>
> \(b\) - SKELETAL/VERTEBRAE (T10 Anlage): Dumbbell shaped centra

H-38

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 2000 MG/M3

> ANIMAL NUMBER: IGL405F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 0 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + + +
>
> 2 A F + +
>
> 3 A F + + +
>
> 4 A M + +
>
> 5 A M + + +
>
> 6 A F + +
>
> 7 A F + + +
>
> 8 A F + +
>
> 9 A M + + +
>
> 10C A F + +
>
> 11 A M + + +
>
> 12 A M + +
>
> 13 A M + + +
>
> 14 A M + +
>
> 15 A F + + +
>
> 16 A M + +
>
> 17 A F + + +
>
> 18 A M + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES

H-39

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 2000 MG/M3

> ANIMAL NUMBER: IGL382F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 1 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + +
>
> 2 A F + + +
>
> 3 A F + +
>
> 4 A F + + +
>
> 5 A M + (a)
>
> 6 A M + + +
>
> 7C A F + +
>
> 8 A F + + +
>
> 9 A F + +
>
> 10 A M + + +
>
> 11 A M + +
>
> 12 A F + + +
>
> 13 A F + +
>
> 14 A M + + +
>
> 15 A M + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/STERNEBRAE (VI): Misshapen

H-40

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 2000 MG/M3

> ANIMAL NUMBER: IGL390F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 1 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + +
>
> 2 A F + + +
>
> 3 A F + (a)
>
> 4 A M + + +
>
> 5 A M + +
>
> 6C A F + + +
>
> 7 A F + +
>
> 8 A M + + +
>
> 9 A F + +
>
> 10 A F + + +
>
> E
>
> 11 A F + +
>
> 12 A F + + +
>
> 13 A F + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/VERTEBRAE (T11): Bifid centra

H-41

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 2000 MG/M3

> ANIMAL NUMBER: IGL358F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 0 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A M + +
>
> 2 A M + + +
>
> 3 A M + +
>
> 4 A F + + +
>
> 5 A M + +
>
> 6 A F + + +
>
> 7 A M + +
>
> 8 A M + + +
>
> 9C A M + +
>
> 10 A M + + +
>
> 11 A F + +
>
> 12 A M + + +
>
> 13 A M + +
>
> 14 A F + + +
>
> 15 A M + +
>
> 16 A F + + +
>
> 17 A F + +
>
> 18 A F + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES

H-42

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 2000 MG/M3

> ANIMAL NUMBER: IGL398F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 1 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A M + +
>
> 2 A M + + +
>
> 3 A M + +
>
> 4 A F + + +
>
> 5 A M + +
>
> 6 A F + + +
>
> 7 A F + +
>
> 8C A M + + +
>
> 9 A F + +
>
> 10 A M + + +
>
> 11 A M + (a)
>
> 12 A M + + +
>
> 13 A M + +
>
> 14 A M + + +
>
> 15 A F + +
>
> 16 A F + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/RIBS (L1): Rudimentary; Left

H-43

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 2000 MG/M3

> ANIMAL NUMBER: IGL350F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 0 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + +
>
> 2 A F + + +
>
> 3 A F + +
>
> 4 A F + + +
>
> 5 A M + +
>
> 6 A M + + +
>
> 7 A M + +
>
> 8C A M + + +
>
> 9 A F + +
>
> 10 A F + + +
>
> 11 A M + +
>
> 12 A F + + +
>
> 13 A F + +
>
> 14 A M + + +
>
> 15 A M + +
>
> 16 A F + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES

H-44

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 2000 MG/M3

> ANIMAL NUMBER: IGL353F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 1
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 1
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 5 MALFORMATIONS: 1
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + + +
>
> 2 A M (A) (B-K,\*) (L,N,O,P,Q,R,s,t,u,W,X,z)
>
> (AA,BB,cc,DD,ee,FF,GG,HH)
>
> 3 A F + + +
>
> 4 A F + (m,y)
>
> 5 A M + + +
>
> 6 A M + (v)
>
> 7 A F + + +
>
> 8 A F + +
>
> 9 A F + + +
>
> 10C A M + (v)
>
> 11 A F + + +
>
> 12 A M + (v)
>
> 13 A M + + +
>
> 14 A F + +
>
> 15 A F + + +
>
> 16 A F + +
>
> 17 A F + + +
>
> 18 A M + +
>
> 19 A F + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES

NOTE:

\(A\) - EXTERNAL: Conjoined twin; Joined at thoracic region; 1 head, 8
limbs, 2 tails, 1 umbilicus

> \(B\) - ABDOMEN/THORAX: Liver, stomach, spleen, entire small intestine
> shared
>
> \(C\) - ABDOMEN/THORAX: Spleen small
>
> \(D\) - ABDOMEN/THORAX: Cecum not evident; bifurcation appears in area
> where cecum would normally reside
>
> \(E\) - ABDOMEN/THORAX: All thoracic and cranial organs shared
>
> \(F\) - ABDOMEN/THORAX: Supernumerary lung lobe; Left
>
> \(G\) - ABDOMEN/THORAX: Double aorta
>
> \(H\) - ABDOMEN/THORAX: Malpositioned carotid and subclavian branches;
> Bilateral
>
> \(I\) - ABDOMEN/THORAX: Malpositioned pulmonary artery branch
>
> \(J\) - ABDOMEN/THORAX: Ventricle small; Left
>
> \(K\) - ABDOMEN/THORAX: Duplicate tongue
>
> (\*) - ABDOMEN/THORAX: All other abdominal organs appear on each side

H-45

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 2000 MG/M3

> ANIMAL NUMBER: IGL353F (cont\'d)
>
> \(L\) - SKELETAL/SKULL
> (Supraoccipital,Interparietal,Parietals,Frontals,Nasals): Duplication
> or extra bones
>
> \(m\) - SKELETAL/SKULL (Interparietal): Misshapen
>
> \(N\) - SKELETAL/PECTORAL GIRDLE (Clavicle): Right side of left twin
> fused to left side of right twin
>
> \(O\) - SKELETAL/PECTORAL GIRDLE (All bones): Duplication or extra
> bones; Bilateral
>
> \(P\) - SKELETAL/FORELIMB (All bones ): Duplication or extra bones
>
> \(Q\) - SKELETAL/FOREPAW (All bones): Duplication or extra bones
>
> \(R\) - SKELETAL/STERNEBRAE (All bones): Duplication or extra bones
>
> \(s\) - SKELETAL/STERNEBRAE (Left twin III): Misshapen
>
> \(t\) - SKELETAL/STERNEBRAE (Left twin IV): Bifid
>
> \(u\) - SKELETAL/STERNEBRAE (Right twin I,IV): Asymmetric form
>
> \(v\) - SKELETAL/STERNEBRAE (VI): Misshapen
>
> \(W\) - SKELETAL/RIBS (All bones): Duplication or extra bones
>
> \(X\) - SKELETAL/RIBS (Right twin T8 left, Left twin T8 right): Fused;
> Left
>
> \(y\) - SKELETAL/RIBS (L1): Rudimentary; Right
>
> \(z\) - SKELETAL/RIBS (Left twin L1): Rudimentary; Right
>
> (AA) - SKELETAL/VERTEBRAE (All bones): Duplication or extra bones
>
> (BB) - SKELETAL/VERTEBRAE (Left twin CE 1-7): Fused
>
> \(cc\) - SKELETAL/VERTEBRAE (Left twin T2): Unossified centra
>
> (DD) - SKELETAL/VERTEBRAE (Left twin T3): Hemicentra
>
> (ee) - SKELETAL/VERTEBRAE (Left twin T11): Bifid centra
>
> (FF) - SKELETAL/PELVIC GIRDLE (All bones): Duplication or extra bones;
> Bilateral
>
> (GG) - SKELETAL/HINDLIMB (All bones): Duplication or extra bones;
> Bilateral
>
> (HH) - SKELETAL/HINDPAW (All bones): Duplication or extra bones;
> Bilateral

H-46

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 2000 MG/M3

> ANIMAL NUMBER: IGL420F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 0 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A M + +
>
> 2 A M + + +
>
> 3 A F + +
>
> 4 A F + + +
>
> E
>
> 5 A M + +
>
> 6 A M + + +
>
> 7 A M + +
>
> 8C A M + + +
>
> 9 A F + +
>
> 10 A F + + +
>
> 11 A F + +
>
> 12 A F + + +
>
> 13 A M + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES

H-47

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 2000 MG/M3

> ANIMAL NUMBER: IGL388F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 1 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A M + +
>
> 2 A F + + +
>
> 3 A M + (a)
>
> 4 A F + + +
>
> 5 A F + +
>
> 6 A F + + +
>
> 7 A F + +
>
> 8C A F + + +
>
> 9 A F + +
>
> 10 A F + + +
>
> 11 A F + +
>
> 12 A F + + +
>
> 13 A M + +
>
> 14 A F + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/RIBS (L1): Rudimentary; Right

H-48

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 2000 MG/M3

> ANIMAL NUMBER: IGL413F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 2 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + + +
>
> 2 A F + (b)
>
> 3 A M + + +
>
> 4 A M + (a)
>
> 5 A M + + +
>
> 6 A M + +
>
> 7 A M + + +
>
> 8 A M + +
>
> 9C A F + + +
>
> 10 A F + +
>
> 11 A M + + +
>
> 12 A F + +
>
> 13 A F + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/RIBS (L1): Rudimentary; Bilateral
>
> \(b\) - SKELETAL/VERTEBRAE (T11): Bifid centra

H-49

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 2000 MG/M3

> ANIMAL NUMBER: IGL414F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 1 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A M + +
>
> 2 A M + + +
>
> 3 A M + +
>
> 4 A F + + +
>
> 5 A M + (a,b)
>
> 6 A M + + +
>
> 7 A M + +
>
> 8 A F + + +
>
> 9C A F + +
>
> 10 A F + + +
>
> 11 A M + +
>
> 12 A F + + +
>
> E
>
> E
>
> 13 A M + +
>
> 14 A F + + +
>
> 15 A F + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/RIBS (L1): Rudimentary; Left
>
> \(b\) - SKELETAL/VERTEBRAE (L1): Dumbbell shaped centra

H-50

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 2000 MG/M3

> ANIMAL NUMBER: IGL433F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 1
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 5 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1\* A F + + (A)
>
> 2 A F + (b)
>
> 3 A M + + +
>
> 4 A F + (e)
>
> 5 A F + + +
>
> 6 A M + +
>
> 7 A F + + +
>
> 8 A F + +
>
> 9 A F + + +
>
> 10 A F + +
>
> 11C A F + + +
>
> 12 A F + (c)
>
> 13 A M + + +
>
> 14 A F + (c)
>
> 15 A F + + +
>
> 16 A F + (d)
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \* - Stunted
>
> \(A\) - ABDOMEN/THORAX: Enlarged atrial chamber; Right
>
> \(b\) - SKELETAL/STERNEBRAE (VI): Misshapen
>
> \(c\) - SKELETAL/RIBS (L1): Rudimentary; Left
>
> \(d\) - SKELETAL/RIBS (L1): Rudimentary; Bilateral
>
> \(e\) - SKELETAL/VERTEBRAE (T11 Anlage): Dumbbell shaped centra

H-51

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 2000 MG/M3

> ANIMAL NUMBER: IGL441F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 2 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + + +
>
> 2 A M + (a)
>
> 3 A M + + +
>
> E
>
> 4 A F + +
>
> 5 A M + + +
>
> 6 A F + +
>
> 7 A M + + +
>
> 8 A M + +
>
> 9C A M + + +
>
> 10 A M + (b)
>
> 11 A F + + +
>
> 12 A F + +
>
> 13 A F + + +
>
> 14 A M + +
>
> 15 A F + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/STERNEBRAE (VI): Advanced
>
> \(b\) - SKELETAL/STERNEBRAE (IV): Asymmetric form

H-52

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 2000 MG/M3

> ANIMAL NUMBER: IGL457F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 3 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + + +
>
> 2 A F + (a)
>
> 3 A M + + +
>
> 4 A M + (b)
>
> 5 A F + + +
>
> 6 A M + +
>
> 7 A M + + +
>
> 8C A M + +
>
> 9 A M + + +
>
> 10 A F + (a)
>
> E
>
> 11 A F + + +
>
> 12 A F + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/RIBS (L1): Rudimentary; Left
>
> \(b\) - SKELETAL/RIBS (L1): Rudimentary; Right

H-53

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 2000 MG/M3

> ANIMAL NUMBER: IGL466F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 1 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A M + +
>
> 2 A M + + +
>
> 3 A M + +
>
> 4 A M + + +
>
> 5 A F + +
>
> 6 A M + + +
>
> 7C A F + +
>
> 8 A F + + +
>
> 9 A F + +
>
> 10 A F + + +
>
> 11 A M + (a)
>
> E
>
> 12 A M + + +
>
> 13 A M + +
>
> 14 A F + + +
>
> 15 A M + +
>
> 16 A F + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/RIBS (L1): Rudimentary; Right

H-54

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 2000 MG/M3

> ANIMAL NUMBER: IGL475F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 1 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1C A F + + +
>
> 2 A F + (a,b)
>
> 3 A M + + +
>
> 4 A M + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/VERTEBRAE (T11): Bifid centra
>
> \(b\) - SKELETAL/VERTEBRAE (T11 Anlage): Dumbbell shaped centra

H-55

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 2000 MG/M3

> ANIMAL NUMBER: IGL488F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 0 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A M + +
>
> 2 A F + + +
>
> 3C A F + +
>
> 4 A M + + +
>
> 5 A M + +
>
> 6 A F + + +
>
> 7 A M + +
>
> 8 A F + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES

H-56

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 2000 MG/M3

> ANIMAL NUMBER: IGL432F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 1
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 2 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + +
>
> 2 A M + + +
>
> 3 A F + +
>
> 4 A M + + +
>
> 5 A F + (b)
>
> 6 A F + + +
>
> 7 A M + +
>
> 8 A M + + +
>
> 9C A M + +
>
> 10 A M + + +
>
> 11 A M + +
>
> 12 A F + + +
>
> 13 A M + +
>
> 14 A F + + (A)
>
> 15 A F + +
>
> 16 A M + + +
>
> 17 A F + (c)
>
> 18 A M + + +
>
> 19 A M + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(A\) - ABDOMEN/THORAX: Elongated innominate artery
>
> \(b\) - SKELETAL/SKULL (Squamosal Process): Hypoplastic; Left
>
> \(c\) - SKELETAL/RIBS (L1): Rudimentary; Right

H-57

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 2000 MG/M3

> ANIMAL NUMBER: IGL477F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 1 MALFORMATIONS: 1
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 1 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + + (a)
>
> 2 A F + +
>
> 3 A F + + +
>
> 4 A M + +
>
> 5C A F + + +
>
> 6 A F + (d,e)
>
> 7 A M + + +
>
> 8 A F + +
>
> 9 A M + + (B,C)
>
> 10 A M + +
>
> 11 A F + + +
>
> 12 A F + +
>
> 13 A F + + +
>
> 14 A M + +
>
> 15 A M + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - ABDOMEN/THORAX: Misshapen spleen
>
> \(B\) - ABDOMEN/THORAX: Hydroureter; Left
>
> \(C\) - ABDOMEN/THORAX: Hydronephrosis; Left
>
> \(d\) - SKELETAL/VERTEBRAE (T11): Bifid centra
>
> \(e\) - SKELETAL/VERTEBRAE (T11 Anlage): Dumbbell shaped centra

H-58

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 10000 MG/M3

> ANIMAL NUMBER: IGL379F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 3 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A M + + +
>
> 2 A F + (a)
>
> 3 A M + + +
>
> 4C A F + +
>
> 5 A M + + +
>
> 6 A F + (a)
>
> 7 A M + + +
>
> 8 A F + (b)
>
> 9 A M + + +
>
> 10 A M + +
>
> 11 A M + + +
>
> 12 A F + +
>
> 13 A F + + +
>
> 14 A M + +
>
> 15 A F + + +
>
> 16 A F + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/RIBS (L1): Rudimentary; Left
>
> \(b\) - SKELETAL/RIBS (L1): Rudimentary; Bilateral

H-59

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 10000 MG/M3

> ANIMAL NUMBER: IGL389F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 0 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A M + + +
>
> 2 A F + +
>
> 3 A F + + +
>
> 4 A F + +
>
> 5 A M + + +
>
> 6 A F + +
>
> 7 A M + + +
>
> 8 A M + +
>
> 9C A M + + +
>
> 10 A M + +
>
> 11 A M + + +
>
> 12 A M + +
>
> 13 A M + + +
>
> 14 A F + +
>
> 15 A F + + +
>
> 16 A M + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES

H-60

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 10000 MG/M3

> ANIMAL NUMBER: IGL391F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 1 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A M + + +
>
> 2 A M + +
>
> 3 A F + + +
>
> E
>
> 4 A M + +
>
> 5 A F + + +
>
> E
>
> 6 A M + +
>
> 7C A F + + +
>
> 8 A M + +
>
> 9 A M + + +
>
> 10 A M + +
>
> 11 A M + + +
>
> 12 A F + +
>
> 13 A F + + +
>
> 14 A F + (a)
>
> 15 A F + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/STERNEBRAE (V): Unossified

H-61

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 10000 MG/M3

> ANIMAL NUMBER: IGL352F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 2 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A M + +
>
> 2 A F + + +
>
> 3 A M + (b)
>
> 4 A F + + +
>
> 5 A F + +
>
> 6 A F + + +
>
> 7C A M + +
>
> 8 A F + + +
>
> 9 A M + (a)
>
> E
>
> 10 A F + + +
>
> 11 A M + +
>
> 12 A M + + +
>
> 13 A F + +
>
> 14 A M + + +
>
> E
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/SKULL (Tympanics): Hypoplastic
>
> \(b\) - SKELETAL/RIBS (L1): Rudimentary; Left

H-62

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 10000 MG/M3

> ANIMAL NUMBER: IGL355F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 7 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + + +
>
> 2 A M + (c,e,f)
>
> 3 A M + + +
>
> 4 A F + (c)
>
> 5 A F + + +
>
> 6 A M + (a,d,g,h,i)
>
> 7 A M + + +
>
> 8 A F + (c)
>
> 9C A F + + +
>
> 10\* A M + (a)
>
> 11 A F + + +
>
> 12 A F + (a)
>
> 13 A M + + +
>
> 14 A M + +
>
> 15 A F + + +
>
> 16 A F + (b)
>
> 17 A M + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \* - Stunted
>
> \(a\) - SKELETAL/STERNEBRAE (V): Unossified
>
> \(b\) - SKELETAL/STERNEBRAE (III-IV): Asymmetric form
>
> \(c\) - SKELETAL/RIBS (L1): Rudimentary; Left
>
> \(d\) - SKELETAL/RIBS (L1): Rudimentary; Bilateral
>
> \(e\) - SKELETAL/VERTEBRAE (T13): Bifid centra
>
> \(f\) - SKELETAL/VERTEBRAE (T13 Anlage): Dumbbell shaped centra
>
> \(g\) - SKELETAL/VERTEBRAE (T11): Bifid centra
>
> \(h\) - SKELETAL/VERTEBRAE (T11 Anlage): Dumbbell shaped centra
>
> \(i\) - SKELETAL/VERTEBRAE (L1): Misshapen centra

H-63

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 10000 MG/M3

> ANIMAL NUMBER: IGL417F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 2 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A M + + +
>
> 2 A M + (a)
>
> 3 A M + + +
>
> 4 A F + (b)
>
> 5 A F + + +
>
> 6 A M + +
>
> 7C A M + + +
>
> 8 A M + +
>
> 9 A M + + +
>
> 10 A M + +
>
> 11 A M + + +
>
> 12 A F + +
>
> 13 A M + + +
>
> 14 A F + +
>
> 15 A F + + +
>
> 16 A M + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/RIBS (L1): Rudimentary; Bilateral
>
> \(b\) - SKELETAL/RIBS (L1): Rudimentary; Left

H-64

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 10000 MG/M3

> ANIMAL NUMBER: IGL378F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 1 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> L
>
> 1 A M + (a)
>
> 2 A M + + +
>
> 3 A F + +
>
> 4 A F + + +
>
> 5 A M + +
>
> 6 A F + + +
>
> 7C A F + +
>
> 8 A M + + +
>
> 9 A M + +
>
> 10 A M + + +
>
> 11 A M + +
>
> 12 A M + + +
>
> E
>
> 13 A F + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/RIBS (L1): Rudimentary; Right

H-65

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 10000 MG/M3

> ANIMAL NUMBER: IGL380F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 2 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + +
>
> 2 A M + + +
>
> 3 A F + +
>
> 4 A M + + +
>
> 5 A M + (a)
>
> 6 A M + + +
>
> 7C A F + +
>
> 8 A M + + +
>
> 9 A F + +
>
> 10 A M + + +
>
> 11 A M + +
>
> 12 A F + + +
>
> 13 A M + +
>
> 14 A M + + +
>
> 15 A F + (a)
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:

(a) \- SKELETAL/STERNEBRAE (VI): Advanced

H-66

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 10000 MG/M3

> ANIMAL NUMBER: IGL348F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 1
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 1 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A M + +
>
> 2 A M + + +
>
> E
>
> 3 A F + +
>
> 4 A M + + +
>
> 5 A M + +
>
> 6 A M + + +
>
> 7 A M + +
>
> 8 A F + + +
>
> 9C A M + +
>
> 10 A M + (A) +
>
> 11 A M + (b)
>
> 12 A M + + +
>
> 13 A F + +
>
> 14 A F + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE: Fetus numbers 3 and 5 found with identification tags detached,
> numbers
>
> arbitrarily assigned for skeletal exams
>
> \(A\) - HEAD: Retinal fold; Right
>
> \(b\) - SKELETAL/RIBS (L1): Rudimentary; Bilateral

H-67

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 10000 MG/M3

> ANIMAL NUMBER: IGL430F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 0 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A M + +
>
> 2 A M + + +
>
> 3 A F + +
>
> 4C A M + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES

H-68

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 10000 MG/M3

> ANIMAL NUMBER: IGL409F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 0 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + + +
>
> 2 A F + +
>
> 3 A F + + +
>
> 4 A F + +
>
> 5 A F + + +
>
> 6 A M + +
>
> 7 A F + + +
>
> 8C A F + +
>
> 9 A F + + +
>
> 10 A F + +
>
> 11 A M + + +
>
> 12 A F + +
>
> 13 A F + + +
>
> 14 A M + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES

H-69

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 10000 MG/M3

> ANIMAL NUMBER: IGL421F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 0 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A M + + +
>
> 2 A F + +
>
> 3 A M + + +
>
> 4C A F + +
>
> 5 A F + + +
>
> 6 A F + +
>
> 7 A F + + +
>
> E
>
> 8 A F + +
>
> 9 A M + + +
>
> 10 A F + +
>
> 11 A M + + +
>
> 12 A F + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES

H-70

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 10000 MG/M3

> ANIMAL NUMBER: IGL423F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 0 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A M + + +
>
> 2 A M + +
>
> 3 A F + + +
>
> 4 A F + +
>
> 5 A M + + +
>
> 6 A M + +
>
> 7 A F + + +
>
> 8 A F + +
>
> 9 A F + + +
>
> 10 A F + +
>
> EC
>
> 11 A M + + +
>
> 12 A F + +
>
> 13 A F + + +
>
> 14 A F + +
>
> 15 A M + + +
>
> 16 A F + +
>
> 17 A M + + +
>
> 18 A F + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES

H-71

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 10000 MG/M3

> ANIMAL NUMBER: IGL440F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 1 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A M + +
>
> 2 A M + + +
>
> 3C A M + +
>
> 4 A M + + +
>
> 5 A F + (a)
>
> 6 A M + + +
>
> 7 A M + +
>
> 8 A F + + +
>
> 9 A M + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/RIBS (L1): Rudimentary; Left

H-72

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 10000 MG/M3

> ANIMAL NUMBER: IGL399F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 3 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + + +
>
> 2 A M + +
>
> 3 A M + + +
>
> 4 A F + (b,c)
>
> 5 A M + + +
>
> 6 A F + (d,e)
>
> 7C A F + + +
>
> 8 A M + +
>
> 9 A M + + +
>
> 10 A M + +
>
> 11 A F + + +
>
> 12 A F + (a)
>
> 13 A M + + +
>
> 14 A M + +
>
> 15 A M + + +
>
> 16 A F + +
>
> 17 A M + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/STERNEBRAE (VI): Misshapen
>
> \(b\) - SKELETAL/VERTEBRAE (T12): Bifid centra
>
> \(c\) - SKELETAL/VERTEBRAE (T12 Anlage): Dumbbell shaped centra
>
> \(d\) - SKELETAL/VERTEBRAE (T11-12): Bifid centra
>
> \(e\) - SKELETAL/VERTEBRAE (T11-12 Anlage): Dumbbell shaped centra

H-73

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 10000 MG/M3

> ANIMAL NUMBER: IGL452F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 2 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A M + +
>
> 2 A M + + +
>
> 3 A F + +
>
> 4 A M + + +
>
> 5 A M + (a)
>
> 6C A F + + +
>
> 7 A M + (b)
>
> 8 A M + + +
>
> 9 A M + +
>
> E
>
> 10 A F + + +
>
> 11 A F + +
>
> 12 A F + + +
>
> 13 A F + +
>
> 14 A F + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/STERNEBRAE (VI): Misshapen
>
> \(b\) - SKELETAL/RIBS (L1): Rudimentary; Left

H-74

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 10000 MG/M3

> ANIMAL NUMBER: IGL436F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 1 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A M + +
>
> 2 A M + + +
>
> 3 A M + +
>
> 4 A M + + +
>
> 5 A M + +
>
> 6 A F + + +
>
> EC
>
> 7 A F + +
>
> 8 A M + + +
>
> 9 A M + (a,b,c)
>
> 10 A M + + +
>
> 11 A M + +
>
> 12 A F + + +
>
> 13 A M + +
>
> 14 A M + + +
>
> 15 A F + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/STERNEBRAE (V): Unossified
>
> \(b\) - SKELETAL/VERTEBRAE (T8): Dumbell centra
>
> \(c\) - SKELETAL/VERTEBRAE (T8 Anlage): Dumbbell shaped centra

H-75

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 10000 MG/M3

> ANIMAL NUMBER: IGL454F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 4 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A M + (a)
>
> 2 A M + + +
>
> 3 A M + (b)
>
> E
>
> 4 A F + + +
>
> 5 A F + +
>
> 6 A F + + +
>
> 7 A F + (a)
>
> 8C A F + + +
>
> 9 A F + (c)
>
> E
>
> 10 A F + + +
>
> 11 A M + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/RIBS: (L1): Rudimentary; Left
>
> \(b\) - SKELETAL/RIBS: (L1): Rudimentary; Bilateral
>
> \(c\) - SKELETAL/VERTEBRAE (T12 Anlage): Dumbbell shaped centra

H-76

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 10000 MG/M3

> ANIMAL NUMBER: IGL461F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 1 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 2 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + + +
>
> 2 A F + +
>
> 3 A M + + +
>
> 4 A M + +
>
> 5 A M + + +
>
> 6C A F + (b)
>
> 7 A F + + +
>
> 8 A M + (c)
>
> 9 A F + + (a)
>
> 10 A M + +
>
> 11 A M + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - ABDOMEN/THORAX: Umbilical artery arises from left side of
> urinary bladder
>
> \(b\) - SKELETAL/FOREPAW (Metacarpal 1 anlage): Misshapen; Left
>
> \(c\) - SKELETAL/RIBS (L1): Rudimentary; Left

H-77

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 10000 MG/M3

> ANIMAL NUMBER: IGL469F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 0 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> C1 A F + + +
>
> 2 A M + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES

H-78

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 10000 MG/M3

> ANIMAL NUMBER: IGL470F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 4 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + (b,c)
>
> 2 A M + + +
>
> 3 A F + +
>
> 4 A M + + +
>
> 5 A M + +
>
> 6 A M + + +
>
> 7 A M + (d,e,f)
>
> 8 A M + + +
>
> 9 A M + +
>
> 10 A M + + +
>
> 11 A F + +
>
> 12C A M + + +
>
> 13 A F + (g)
>
> 14 A M + + +
>
> 15 A F + +
>
> 16 A M + + +
>
> 17 A M + (a,h)
>
> 18 A F + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/RIBS (L1): Rudimentary; Left
>
> \(b\) - SKELETAL/VERTEBRAE (T10): Bifid centra
>
> \(c\) - SKELETAL/VERTEBRAE (T10 Anlage): Dumbbell shaped centra
>
> \(d\) - SKELETAL/VERTEBRAE (T8): Dumbbell shaped centra
>
> \(e\) - SKELETAL/VERTEBRAE (T11): Bifid centra
>
> \(f\) - SKELETAL/VERTEBRAE (T11 Anlage): Dumbbell shaped centra
>
> \(g\) - SKELETAL/VERTEBRAE (T10-11 Anlage): Dumbbell shaped centra

\(h\) - SKELETAL/VERTEBRAE (L1): Dumbbell shaped centra

H-79

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 10000 MG/M3

> ANIMAL NUMBER: IGL473F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 2 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + + +
>
> 2 A M + +
>
> 3 A M + + +
>
> E
>
> 4 A F + (a)
>
> 5 A F + + +
>
> 6 A F + +
>
> 7C A M + + +
>
> 8 A F + +
>
> 9 A F + + +
>
> 10 A F + +
>
> 11 A M + + +
>
> 12 A M + (b)
>
> 13 A M + + +
>
> 14 A F + +
>
> 15 A M + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/RIBS (L1): Rudimentary; Left
>
> \(b\) - SKELETAL/RIBS (L1): Rudimentary; Bilateral

H-80

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 10000 MG/M3

> ANIMAL NUMBER: IGL407F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 2 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 3 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + + +
>
> 2 A F + +
>
> 3 A F + + +
>
> 4 A M + (c)
>
> 5 A M + + (a)
>
> 6 A M + +
>
> 7 A M + + +
>
> 8 A F + +
>
> 9 A F + + +
>
> 10 A F + (b)
>
> 11C A F + + (a)
>
> 12 A F + +
>
> 13 A F + + +
>
> 14 A F + +
>
> 15 A M + + +
>
> 16 A M + (c)
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - ABDOMEN/THORAX: Umbilical artery arises from left side of
> urinary bladder
>
> \(b\) - SKELETAL/STERNEBRAE (VI): Hypoplastic
>
> \(c\) - SKELETAL/RIBS (L1): Rudimentary; Bilateral

H-81

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 10000 MG/M3

> ANIMAL NUMBER: IGL442F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 1 MALFORMATIONS: 1
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + +
>
> 2 A F + + +
>
> 3 A F + +
>
> 4 A F + + +
>
> 5C A M + +
>
> 6 A M + + +
>
> 7 A F + +
>
> 8 A F + + +
>
> 9 A F + +
>
> 10 A M + + +
>
> 11 A F + (a,B)
>
> 12 A M + + +
>
> 13 A F + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/RIBS (T13): Short last rib; Right
>
> \(B\) - SKELETAL/VERTEBRAE (L): One less presacral vertebrae

H-82

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 20000 MG/M3

> ANIMAL NUMBER: IGL364F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 3 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + +
>
> 2 A M + + +
>
> 3 A M + +
>
> 4 A F + + +
>
> 5 A F + +
>
> 6C A M + + +
>
> 7 A M + (a)
>
> 8 A M + + +
>
> 9 A M + +
>
> 10 A M + + +
>
> 11 A F + +
>
> 12 A M + + +
>
> 13 A F + +
>
> 14 A M + + +
>
> 15 A F + (a)
>
> 16 A M + + +
>
> 17 A F + (b)
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/RIBS (L1): Rudimentary; Left
>
> \(b\) - SKELETAL/RIBS (L1): Rudimentary; Bilateral

H-83

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 20000 MG/M3

> ANIMAL NUMBER: IGL367F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 2 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A M + + +
>
> 2 A M + +
>
> 3 A M + + +
>
> 4 A M + +
>
> 5 A M + + +
>
> 6 A M + +
>
> 7 A F + + +
>
> 8C A M + (a)
>
> 9 A F + + +
>
> 10 A M + +
>
> 11 A F + + +
>
> 12 A M + (b)
>
> 13 A F + + +
>
> 14 A M + +
>
> 15 A M + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/STERNEBRAE (V): Unossified
>
> \(b\) - SKELETAL/RIBS (L1): Rudimentary; Left

H-84

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 20000 MG/M3

> ANIMAL NUMBER: IGL368F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 1 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + +
>
> 2 A M + + +
>
> 3 A M + +
>
> 4 A F + + +
>
> 5 A M + +
>
> 6\* A M + + +
>
> 7 A M + +
>
> 8C A F + + +
>
> 9 A M + +
>
> 10 A M + + +
>
> 11 A M + +
>
> 12 A M + + +
>
> 13 A F + (a)
>
> 14 A F + + +
>
> 15 A M + +
>
> 16 A F + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \* - Stunted
>
> \(a\) - SKELETAL/VERTEBRAE (T9): Dumbbell shaped centra

H-85

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 20000 MG/M3

> ANIMAL NUMBER: IGL375F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 2 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> L
>
> 1 A F + + +
>
> 2 A M + +
>
> 3 A M + + +
>
> 4 A F + (c)
>
> 5 A F + + +
>
> 6 A M + +
>
> 7 A M + + +
>
> 8C\* A M + (a,b)
>
> 9 A M + + +
>
> 10 A M + +
>
> 11 A M + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \* - Stunted
>
> \(a\) - SKELETAL/STERNEBRAE (V): Unossified
>
> \(b\) - SKELETAL/STERNEBRAE (VI): Misshapen
>
> \(c\) - SKELETAL/RIBS (L1): Rudimentary; Right

H-86

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 20000 MG/M3

> ANIMAL NUMBER: IGL363F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 1 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A M + + +
>
> 2 A M + +
>
> 3 A M + + +
>
> 4C A M + (a)
>
> 5 A M + + +
>
> 6 A F + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/RIBS (L1): Rudimentary; Right

H-87

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 20000 MG/M3

> ANIMAL NUMBER: IGL373F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 1 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + + +
>
> 2 A F + (a,b)
>
> 3 A M + + +
>
> E
>
> 4 A F + +
>
> 5 A F + + +
>
> 6 A F + +
>
> 7 A F + + +
>
> 8C A M + +
>
> 9 A F + + +
>
> 10 A M + +
>
> 11 A F + + +
>
> 12 A F + +
>
> 13 A M + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/VERTEBRAE (T11): Bifid centra
>
> \(b\) - SKELETAL/VERTEBRAE (T6): Dumbbell shaped centra

H-88

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 20000 MG/M3

> ANIMAL NUMBER: IGL397F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 1 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + + +
>
> 2 A M + +
>
> 3 A M + + +
>
> 4 A M + +
>
> 5 A F + + +
>
> 6 A F + +
>
> 7 A M + + +
>
> 8 A M + +
>
> 9 A F + + +
>
> 10 A M + +
>
> 11C A F + + +
>
> 12 A M + +
>
> 13 A F + + +
>
> 14 A F + (a)
>
> 15 A M + + +
>
> 16 A F + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:

(a) \- SKELETAL/RIBS (L1): Rudimentary; Left

H-89

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 20000 MG/M3

> ANIMAL NUMBER: IGL357F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 5 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1\* D F + + +
>
> 2 A F + +
>
> 3\* A M + + +
>
> 4\* A F + (a,b)
>
> 5 A F + + +
>
> 6 A F + (c)
>
> 7 A M + + +
>
> 8 A F + +
>
> 9 A F + + +
>
> 10 A M + (c,d)
>
> 11 A M + + +
>
> 12C A M + (d,e)
>
> 13 A F + + +
>
> 14 A M + +
>
> 15\* A F + + +
>
> 16\* A F + (c,e)
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \* - Stunted
>
> \(a\) - SKELETAL/STERNEBRAE (II-IV): Dumbbell-shaped
>
> \(b\) - SKELETAL/STERNEBRAE (V-VI): Unossified
>
> \(c\) - SKELETAL/STERNEBRAE (V): Unossified
>
> \(d\) - SKELETAL/STERNEBRAE (VI): Asymmetric form
>
> \(e\) - SKELETAL/STERNEBRAE (IV): Dumbbell-shaped

H-90

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 20000 MG/M3

> ANIMAL NUMBER: IGL369F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 3 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + + +
>
> 2 A M + (a)
>
> 3 A F + + +
>
> 4 A M + +
>
> E
>
> 5C A F + + +
>
> 6 A M + +
>
> 7 A M + + +
>
> 8 A F + (c)
>
> 9 A F + + +
>
> 10 A F + +
>
> 11 A F + + +
>
> 12 A F + (b)
>
> 13 A M + + +
>
> 14 A F + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/STERNEBRAE (V): Unossified
>
> \(b\) - SKELETAL/STERNEBRAE (VI): Misshapen
>
> \(c\) - SKELETAL/RIBS (L1): Rudimentary; Right

H-91

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 20000 MG/M3

> ANIMAL NUMBER: IGL404F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 0 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A M + +
>
> 2 A F + + +
>
> 3 A F + +
>
> 4 A M + + +
>
> 5 A M + +
>
> 6C A F + + +
>
> 7 A F + +
>
> 8 A F + + +
>
> 9 A M + +
>
> 10 A M + + +
>
> 11 A F + +
>
> 12 A F + + +
>
> 13 A F + +
>
> 14 A F + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES

H-92

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 20000 MG/M3

> ANIMAL NUMBER: IGL365F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 0 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A M + + +
>
> 2 A M + +
>
> 3 A M + + +
>
> 4 A M + +
>
> 5 A F + + +
>
> 6 A F + +
>
> E
>
> 7C A M + + +
>
> 8 A F + +
>
> 9 A M + + +
>
> 10 A F + +
>
> 11 A M + + +
>
> 12 A M + +
>
> 13 A F + + +
>
> 14 A M + +
>
> 15 A F + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES

H-93

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 20000 MG/M3

> ANIMAL NUMBER: IGL366F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 1
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 1 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1\* A F + (b,c,d,e)
>
> 2 A M + + +
>
> 3 A F + +
>
> 4 A F + (A) +
>
> 5 A M + +
>
> 6 A M + + +
>
> 7C A M + +
>
> 8 A F + + +
>
> 9 A F + +
>
> 10 A M + + +
>
> 11 A M + +
>
> 12 A F + + +
>
> 13 A F + +
>
> 14 A M + + +
>
> 15 A M + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \* - Stunted
>
> \(A\) - HEAD: Open eye; Right
>
> \(b\) - SKELETAL/STERNEBRAE (II,III,VI): Hypoplastic
>
> \(c\) - SKELETAL/STERNEBRAE (V): Unossified
>
> \(d\) - SKELETAL/STERNEBRAE (IV): Bifid
>
> \(e\) - SKELETAL/RIBS (L1): Rudimentary; Left

H-94

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 20000 MG/M3

> ANIMAL NUMBER: IGL372F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 4 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + +
>
> 2 A F + + +
>
> 3 A M + (a)
>
> 4 A M + + +
>
> 5 A M + (b)
>
> 6 A M + + +
>
> 7 A M + +
>
> 8C A M + + +
>
> 9 A F + +
>
> 10 A F + + +
>
> 11 A M + (a)
>
> E
>
> 12 A F + + +
>
> 13 A M + (a)
>
> 14 A M + + +
>
> 15 A M + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/RIBS (L1): Rudimentary; Right
>
> \(b\) - SKELETAL/RIBS (L1): Rudimentary; Left

H-95

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 20000 MG/M3

> ANIMAL NUMBER: IGL396F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 0 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A M + +
>
> 2 A M + + +
>
> 3 A F + +
>
> 4 A F + + +
>
> 5 A F + +
>
> 6C A M + + +
>
> 7 A F + +
>
> 8 A F + + +
>
> 9 A F + +
>
> 10 A F + + +
>
> 11 A M + +
>
> 12 A F + + +
>
> 13 A M + +
>
> 14 A M + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES

H-96

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 20000 MG/M3

> ANIMAL NUMBER: IGL371F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 2 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + + +
>
> 2 A F + +
>
> 3 A M + + +
>
> 4 A M + (a)
>
> 5 A F + + +
>
> 6 A M + +
>
> 7 A F + + +
>
> 8 A M + (b)
>
> EC
>
> 9 A F + + +
>
> 10 A M + +
>
> 11 A F + + +
>
> 12 A F + +
>
> 13 A M + + +
>
> 14 A F + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/RIBS (L1): Rudimentary; Left
>
> \(b\) - SKELETAL/RIBS (L1): Rudimentary; Right

H-97

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 20000 MG/M3

> ANIMAL NUMBER: IGL410F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 4 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A M + (b)
>
> 2 A M + + +
>
> 3 A F + (c)
>
> 4 A F + + +
>
> 5 A F + (a,d)
>
> 6 A F + + +
>
> 7 A F + +
>
> 8C A M + + +
>
> 9 A F + +
>
> 10 A M + + +
>
> 11 A M + (c,e,f,g)
>
> 12 A F + + +
>
> 13 A F + +
>
> 14 A F + + +
>
> 15 A M + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/STERNEBRAE (VI): Misshapen
>
> \(b\) - SKELETAL/RIBS (L1): Rudimentary; Bilateral
>
> \(c\) - SKELETAL/RIBS (L1): Rudimentary; Right
>
> \(d\) - SKELETAL/RIBS (L1): Rudimentary; Left
>
> \(e\) - SKELETAL/RIBS (L1): Well-formed; Left
>
> \(f\) - SKELETAL/VERTEBRAE (T12): Bifid centra
>
> \(g\) - SKELETAL/VERTEBRAE (T12 Anlage): Dumbbell shaped centra

H-98

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 20000 MG/M3

> ANIMAL NUMBER: IGL415F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 1
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 0 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + + +
>
> 2 A M + +
>
> 3 A M + + +
>
> 4 A F + +
>
> 5 A F + + +
>
> 6 A F + +
>
> 7 A M + + +
>
> 8C A F + +
>
> 9 A M + + +
>
> 10 A M + +
>
> 11 A M + + (A)
>
> 12 A F + +
>
> 13 A M + + +
>
> 14 A M + +
>
> 15 A M + + +
>
> 16 A F + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:

\(A\) - ABDOMEN/THORAX: Umbilical artery aneurysm

H-99

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 20000 MG/M3

> ANIMAL NUMBER: IGL444F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 3 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + +
>
> 2 A M + + +
>
> 3 A F + +
>
> 4 A M + + +
>
> 5 A M + +
>
> 6 A F + + +
>
> 7C A M + (a,c,d)
>
> 8 A F + + +
>
> 9 A M + +
>
> 10 A F + + +
>
> 11 A F + (b)
>
> 12 A F + + +
>
> 13 A F + (b)
>
> 14 A F + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/STERNEBRAE (V): Misshapen
>
> \(b\) - SKELETAL/RIBS (L1): Rudimentary; Left
>
> \(c\) - SKELETAL/VERTEBRAE (T11): Bifid centra
>
> \(d\) - SKELETAL/VERTEBRAE (T11 Anlage): Dumbbell shaped centra

H-100

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 20000 MG/M3

> ANIMAL NUMBER: IGL449F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 2 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + + +
>
> 2 A M + +
>
> 3 A F + + +
>
> 4 A F + +
>
> 5 A F + + +
>
> 6 A F + +
>
> 7 A M + + +
>
> 8 A M + (a)
>
> 9 A F + + +
>
> 10C A F + +
>
> 11 A F + + +
>
> 12 A M + (b)
>
> 13 A M + + +
>
> 14 A M + +
>
> 15 A M + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/RIBS (L1): Rudimentary; Left
>
> \(b\) - SKELETAL/VERTEBRAE (CE3 Anlage): Bifid centra

H-101

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 20000 MG/M3

> ANIMAL NUMBER: IGL458F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 0 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + +
>
> 2 A M + + +
>
> 3 A M + +
>
> 4 A F + + +
>
> 5C A F + +
>
> 6 A M + + +
>
> 7 A M + +
>
> 8 A F + + +
>
> 9 A F + +
>
> 10 A M + + +
>
> 11 A M + +
>
> 12 A F + + +
>
> 13 A F + +
>
> 14 A F + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES

H-102

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 20000 MG/M3

> ANIMAL NUMBER: IGL471F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 0 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + + +
>
> 2 A F + +
>
> 3 A M + + +
>
> 4 A F + +
>
> 5 A F + + +
>
> 6C A M + +
>
> 7 A F + + +
>
> 8 A M + +
>
> 9 A F + + +
>
> 10\* A F + +
>
> 11 A M + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \* - Stunted

H-103

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 20000 MG/M3

> ANIMAL NUMBER: IGL424F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 4 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + (a)
>
> 2 A F + + +
>
> 3 A M + (b)
>
> E
>
> 4 A M + + +
>
> 5 A M + (c,d)
>
> 6 A F + + +
>
> 7C A M + +
>
> 8 A M + + +
>
> 9 A M + +
>
> 10 A M + + +
>
> 11 A F + +
>
> 12 A M + + +
>
> 13 A F + +
>
> 14 A F + + +
>
> 15 A F + (a)
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/STERNEBRAE (V): Unossified
>
> \(b\) - SKELETAL/STERNEBRAE (VI): Misshapen
>
> \(c\) - SKELETAL/VERTEBRAE (T10): Bifid centra
>
> \(d\) - SKELETAL/VERTEBRAE (T10 Anlage): Dumbbell shaped centra

H-104

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 20000 MG/M3

> ANIMAL NUMBER: IGL428F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 2 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + (a)
>
> 2 A M + + +
>
> 3 A M + +
>
> 4 A F + + +
>
> 5 A M + +
>
> 6 A M + + +
>
> 7 A F + (a)
>
> 8 A F + + +
>
> EC
>
> 9 A F + +
>
> 10 A F + + +
>
> 11 A F + +
>
> 12 A F + + +
>
> 13 A M + +
>
> 14 A M + + +
>
> 15 A F + +
>
> 16 A F + + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/RIBS (L1): Rudimentary; Left

H-105

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE: 20000 MG/M3

> ANIMAL NUMBER: IGL439F
>
> NUMBER OF FETUSES WITH EXTERNAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH VISCERAL VARIATIONS: 0 MALFORMATIONS: 0
>
> NUMBER OF FETUSES WITH SKELETAL VARIATIONS: 1 MALFORMATIONS: 0
>
> FETUS \| STATUS \| SEX \| EXTERNAL \| VISCERAL \| SKELETAL \|
>
> NO. \| \| \| \| HEAD \| ABDOMEN/THORAX \| \|
>
> \-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\-\--\|\-\-\-\-\-\-\-\-\-\-\--\|
>
> 1 A F + + +
>
> 2 A F + +
>
> 3 A M + + +
>
> 4 A F + +
>
> 5 A M + + +
>
> 6 A F + (a)
>
> 7 A M + + +
>
> 8 A M + +
>
> 9C A F + + +
>
> 10 A M + +
>
> 11 A F + + +
>
> 12 A M + +
>
> 13 A M + + +
>
> 14 A M + +
>
> 15 A M + + +
>
> 16 A F + +
>
> A = ALIVE M = MALE E = EARLY RESORPTION C = CERVIX
>
> D = DEAD F = FEMALE L = LATE RESORPTION + = NO OBSERVABLE
> ABNORMALITIES
>
> NOTE:
>
> \(a\) - SKELETAL/VERTEBRAE (T11): Bifid centra

H-106

**APPENDIX I - INHALATION EXPOSURE DATA**

TABLE OF CONTENTS

EXPOSURE CHAMBERS I-2

TEST ATMOSPHERE GENERATION I-2

CHAMBER ENVIRONMENTAL CONDITIONS I-2

ANALYTICAL PROCEDURES I-3

CHAMBER HOMOGENEITY I-4

LIGHTING, NOISE, AND OXYGEN LEVELS I-4

PARTICLE SIZE ANALYSIS I-4

**LIST OF FIGURES**

[Figure]{.underline} [Page]{.underline}

FIGURE I-1. Schematic of generation and exposure system I-5

FIGURE I-2. Schematic of analytical calibration system I-6

FIGURE I-3. Analytical calibration response curves I-9

**LIST OF TABLES**

[Table]{.underline} [Page]{.underline}

TABLE I-1. Mean exposure data I-7

TABLE I-2. Gas chromatograph operating conditions I-8

TABLE I-3. Summary of exposure data I-10

TABLE I-4. Summary of chamber distribution sampling I-19

TABLE I-5. Lighting, noise, and oxygen levels I-20

TABLE I-6. Particle size data I-21

TABLE I-7. Chamber temperatures and humidities I-23

I-1

**APPENDIX I - INHALATION EXPOSURE DATA**

**Exposure Chambers**

The chambers used in this study were constructed of stainless steel and
glass and had a total volume of approximately 1.0 m^3^. They were
operated at an airflow rate of 200 liters per minute ensuring 12 air
changes per hour and a theoretical equilibration time (T~99~) of 23
minutes. The chamber volume and airflow were considered adequate to
ensure an oxygen level greater than 19% and an animal loading below 5%.
The chamber airflow rate was monitored continuously with a calibrated
flow-limiting orifice and differential pressure gauge and recorded
approximately every 30 minutes. All of the chambers were maintained at a
slight negative pressure to the room.

**Test Atmosphere Generation**

Figure I-1 presents a schematic of the test atmosphere generation and
exposure system.

Aliquots of the test substance for use in the daily conduct of the study
were received in gas cylinders (\~20 L nominal volume) via a specially
constructed distribution manifold. A manifold system maintained the test
substance under nitrogen pressure, ensuring that the transferred
substance remained in liquid phase and retained the same composition as
the original container.

The test substance was delivered via a diptube from the outlet valve of
the cylinder to a variable area rotameter which regulated the rate of
liquid flow into a heated glass round-bottom flask. The test substance
volatilized within the flask and the resulting vapors mixed with the
supply air as they were drawn into the exposure chamber.

**Chamber Environmental Conditions**

Chamber temperature and humidity were monitored by wet/dry bulb
hygrometers and recorded at approximately thirty minute intervals
throughout each exposure***.***

I-2

**APPENDIX I - INHALATION EXPOSURE DATA**

**Analytical Procedures**

Schematic of the analytical calibration system: Figure I-2.

Analytical calibration response curve: Figure I-3

Mean exposure data: Table I-1

Gas chromatograph operating conditions: Table I-2

Summary of exposure data: Table I-3

Exposure concentrations were determined on both a nominal and analytical
basis. Nominal concentrations for each exposure level were calculated by
weighing the tank containing the test substance before and after
exposure and dividing the net loss in weight by the total volume of air
passing through the chamber during the exposure.

Analytical exposure concentrations were determined hourly during each
exposure by on-line gas chromatography (Hewlett Packard 6890). Samples
of the chamber atmosphere were continuously delivered to the GC via 1/8"
teflon tubing connected to an automated 12-port multiposition gas
sampling valve. The multiposition valve was programmed to sequentially
direct each stream to a sample loop which injected a fixed sample volume
(2 cc) directly onto the column for analysis. A complete sampling cycle
was performed during each hour of exposure.

The analytical system was calibrated against a series of known
concentrations of the test substance in air. The air concentrations were
determined by injecting a weighed amount of the test substance from a
gas-tight syringe into a closed loop system of a known air volume (see
schematical drawing). The closed loop system consisted of an infrared
vapor analyzer (MIRAN 1A-CVF, Foxboro Analytical) connected to the gas
sampling valve of the GC. A metal bellows pump was used to circulate the
injected test substance vapors through the sample cell of the infrared
monitor and the gas sampling valve of the GC. The response of the
infrared analyzer was monitored until the air concentration appeared
equilibrated and stable, then three replicate samples were taken using
the gas sample loop of the GC. The entire closed loop system was cleared
with clean air between each calibration injection. The average response
of the GC (total peak area) for the four main constituents of the
atmosphere, at each air concentration was used to construct a linear
calibration for the test substance.

This method permitted the GC and the infrared analyzer (a backup
analytical method) to be calibrated simultaneously and under conditions
similar to actual chamber sampling. Once established, the calibration
was checked daily during the study by sampling a certified standard of
n-butane, the major component of the test substance mixture.

I-3

**APPENDIX I - INHALATION EXPOSURE DATA**

**Chamber Homogeneity**

Table I-4 presents a summary of the chamber distribution data.

During the method development trials for this study, samples were drawn
from twelve different points within the chamber at each target
concentration to demonstrate the homogeneity of test atmosphere
distribution.

**Lighting, Noise and Oxygen Levels**

Table I-5 presents a summary of the lighting, noise, and oxygen level
data.

Light intensity was measured three times during the study (the first day
of exposures, during the second week of exposures, and the last day of
exposures) in both the animal room and the chamber room. Light intensity
was measured in the animal room in a cage approximately three feet above
the floor level. In the chamber room the light intensity was measured
three feet above floor level in the approximate center of each
generation room.

Additionally, the oxygen level and the noise level were measured in each
exposure chamber on the first day of exposures, during the second week
of exposures, and on the last day of exposures.

**Particle Size Analysis.**

Table I-6 presents a summary of the particle size data.

A particle size determination of the aerosol portion of the test
atmosphere was conducted during the chamber trials from the control and
20,000 mg/m^3^ target concentration chambers. The particle size sampling
indicated aerosol concentrations of 0 and 20 mg/m^3^ for the control and
20,000 mg.m^3^ target concentration chambers. These small concentrations
of aerosol were likely due to animal hair or dander.

The sample was taken using a multistage cascade impactor. Preweighed
glass fiber filters were used to collect aerosol on each stage. Each
stage was associated with specific cutoff diameters for aerodynamic
particle size in microns.

The flow of air and the duration of the flow were recorded in the data.
This provided the information needed to convert the amount of aerosol
captured in the cascade impactor to a chamber concentration.

I-4

**APPENDIX I - INHALATION EXPOSURE DATA**

**FIGURE I-1 - SCHEMATIC OF GENERATION AND EXPOSURE SYSTEM**

I-5

**APPENDIX I - INHALATION EXPOSURE DATA**

**FIGURE I-2 - SCHEMATIC OF ANALYTICAL CALIBRATION SYSTEM**

![](media/image1.wmf)

I-6

**APPENDIX I - INHALATION EXPOSURE DATA**

**TABLE I-1 - MEAN EXPOSURE DATA**

+-----------------------+-----------+-----------+-----------+-----------+
| **GROUP:**            | **1**     | **2**     | **3**     | **4**     |
+-----------------------+-----------+-----------+-----------+-----------+
| Target Exposure       | 0         | 2000      | 10000     | 20000     |
| Concentration         |           |           |           |           |
|                       |           |           |           |           |
| (mg/m^3^)             |           |           |           |           |
+-----------------------+-----------+-----------+-----------+-----------+
| Mean Analytical       | 0         | 1988      | 10327     | 20541     |
| Exposure              |           |           |           |           |
| Concentration         |           |           |           |           |
|                       |           |           |           |           |
| (mg/m^3^)             |           |           |           |           |
+-----------------------+-----------+-----------+-----------+-----------+
| Average Chamber       | 69        | 72        | 75        | 72        |
| Temperature           |           |           |           |           |
|                       |           |           |           |           |
| (^O^F)                |           |           |           |           |
+-----------------------+-----------+-----------+-----------+-----------+
| Average Chamber       | 62        | 58        | 54        | 58        |
| Relative Humidity     |           |           |           |           |
|                       |           |           |           |           |
| (% RH)                |           |           |           |           |
+-----------------------+-----------+-----------+-----------+-----------+

I-7

**APPENDIX I - INHALATION EXPOSURE DATA**

**TABLE I-2 - GAS CHROMATOGRAPH OPERATING CONDITIONS**

> GAS CHROMATOGRAPH: Hewlett Packard 6890GC
>
> DETECTOR: Flame Ionization
>
> COLUMN: Supelco Part \# 13867, MTO-SS, 2M 1/8",
>
> Carbopack C 80/100 0.19% Picric Acid 15g
>
> GAS FLOWS (cc/min): H~2~ - 45.0
>
> Air - 450.0
>
> Makeup Gas (Helium) - 30.0
>
> INLET TEMPERATURE: 100^o^C
>
> INLET FLOW (cc/min) Helium - 19.8
>
> OVEN TEMPERATURE: 110^o^C
>
> DETECTOR TEMPERATURE: 250^o^C
>
> SAMPLE LOOP SIZE: 2 cc
>
> ATTENUATION: 0
>
> RUN TIME: 8.5 Minutes

I-8

**APPENDIX I - INHALATION EXPOSURE DATA**

**FIGURE I-3 - ANALYTICAL CALIBRATION RESONSE CURVES**

![](media/image2.wmf)

![](media/image3.wmf)

I-9

**APPENDIX I - INHALATION EXPOSURE DATA**

**TABLE I-3 - SUMMARY OF EXPOSURE DATA**

  ------------- ----------- ----------- --------- ----- ----------- ----------- --------- ----- ----------- ----------- --------- ----- ----------- ----------- --------- -----
                Group 1                                 Group 2                                 Group 3                                 Group 4                           

  Date          Mean        Nominal     Chamber         Mean        Nominal     Chamber         Mean        Nominal     Chamber         Mean        Nominal     Chamber   

                (mg/m^3^)   (mg/m^3^)   ^o^F      \% Rh (mg/m^3^)   (mg/m^3^)   ^o^F      \% Rh (mg/m^3^)   (mg/m^3^)   ^o^F      \% Rh (mg/m^3^)   (mg/m^3^)   ^o^F      \% Rh

  27-Apr-02     0           0           67        64    1733        2088        69        59    10392       10360       71        58    21400       19922       69        59

  28-Apr-02     0           0           68        64    1991        2089        70        58    10622       9388        74        51    21646       19743       70        57

  29-Apr-02     0           0           68        55    2179        1933        70        50    10699       10363       74        47    21121       19524       70        57

  30-Apr-02     0           0           68        65    2050        1950        70        58    10443       10272       73        58    21167       19432       70        59

  1-May-02      0           0           70        59    1979        2375        71        58    10736       10581       75        49    20984       19547       72        55

  2-May-02      0           0           69        64    2076        2069        71        64    10293       10335       75        54    20177       18992       72        61

  3-May-02      0           0           70        58    1929        1924        72        61    10304       10297       76        50    21320       19390       72        58

  4-May-02      0           0           68        64    2016        1736        71        61    9793        9913        74        59    20473       19208       72        56

  5-May-02      0           0           68        64    1967        1924        74        52    10652       10435       75        53    20603       19501       72        58

  6-May-02      0           0           69        70    1913        1896        71        69    9762        10168       75        61    20594       19035       72        65

  7-May-02      0           0           70        65    1965        1981        73        62    10297       10306       76        57    20438       19501       73        61

  8-May-02      0           0           70        62    1910        1914        72        59    9816        10056       75        58    19934       18799       73        61

  9-May-02      0           0           70        58    1965        1856        73        59    10389       10632       75        57    20077       19921       71        62

  10-May-02     0           0           70        65    2022        1976        73        60    10224       10246       76        55    19785       18965       73        62

  11-May-02     0           0           71        65    1941        1953        75        59    10367       10443       76        55    20145       19547       74        59

  12-May-02     0           0           70        69    2134        2032        74        59    10270       10435       75        61    20100       19274       74        66

  13-May-02     0           0           70        72    1943        1956        74        59    10232       10364       76        59    20057       19578       74        61

  14-May-02     0           0           70        55    2076        2018        72        50    10441       10611       76        47    20251       19531       73        49

  15-May-02     0           0           69        61    2034        2032        72        57    10422       10646       75        54    20642       19526       73        54

  16-May-02     0           0           68        58    1982        1969        70        58    10565       10789       75        52    20162       19350       71        54

  17-May-02     0           0           68        64    2008        2093        70        58    10431       10606       74        54    20615       19790       71        58

  18-May-02     0           0           68        59    1909        2244        71        51    9805        10442       74        50    20649       19551       71        54

  19-May-02     0           0           68        65    1906        1936        72        58    10598       10763       73        59    20386       19767       71        58

  20-May-02     0           0           66        63    2032        1988        70        58    10173       10385       73        53    21014       20071       70        58

  21-May-02     0           0           67        54    2033        2035        69        56    10449       10628       74        47    19793       19257       70        54

  **MEAN**      0           0           69        62    1988        1999        72        58    10327       10379       75        54    20541       19469       72        58

  **S.D.**      0           0           1.3       4.6   87.7        124.2       1.6       4.2   280.2       293.4       1.2       4.4   518.3       314.5       1.4       3.8

  **Minimum**   0           0           66        54    1733        1736        69        50    9762        9388        71        47    19785       18799       69        49

  **Maximum**   0           0           71        72    2179        2375        75        69    10736       10789       76        61    21646       20071       74        66
  ------------- ----------- ----------- --------- ----- ----------- ----------- --------- ----- ----------- ----------- --------- ----- ----------- ----------- --------- -----

I-10

**APPENDIX I - INHALATION EXPOSURE DATA**

**TABLE I-3 - SUMMARY OF EXPOSURE DATA (CONT'D)**

**GROUP 1 - 0 MG/M^3^ TARGET CONCENTRATION**

  ----------- ---------- --------------- --------------- ------------- --------------
                         Nominal         Mean Analytical Mean          Mean

              Exposure   Concentration   Concentration   Temperature   Relative
                                                                       Humidity

  Date        Number     (mg/m^3^)       (mg/m^3^)       (^o^F)        (%)

  27-Apr-02   1          0               0               67            64

  28-Apr-02   2          0               0               68            64

  29-Apr-02   3          0               0               68            55

  30-Apr-02   4          0               0               68            65

  1-May-02    5          0               0               70            59

  2-May-02    6          0               0               69            64

  3-May-02    7          0               0               70            58

  4-May-02    8          0               0               68            64

  5-May-02    9          0               0               68            64

  6-May-02    10         0               0               69            70

  7-May-02    11         0               0               70            65

  8-May-02    12         0               0               70            62

  9-May-02    13         0               0               70            58

  10-May-02   14         0               0               70            65

  11-May-02   15         0               0               71            65
  ----------- ---------- --------------- --------------- ------------- --------------

I-11

**APPENDIX I - INHALATION EXPOSURE DATA**

**TABLE I-3 - SUMMARY OF EXPOSURE DATA (CONT'D)**

**GROUP 1 - 0 MG/M^3^ TARGET CONCENTRATION**

  ----------- ---------- --------------- --------------- ------------- --------------
                         Nominal         Mean Analytical Mean          Mean

              Exposure   Concentration   Concentration   Temperature   Relative
                                                                       Humidity

  Date        Number     (mg/m^3^)       (mg/m^3^)       (^o^F)        (%)

  12-May-02   16         0               0               70            69

  13-May-02   17         0               0               70            72

  14-May-02   18         0               0               70            55

  15-May-02   19         0               0               69            61

  16-May-02   20         0               0               68            58

  17-May-02   21         0               0               68            64

  18-May-02   22         0               0               68            59

  19-May-02   23         0               0               68            65

  20-May-02   24         0               0               66            63

  21-May-02   25         0               0               67            54

  **Mean**               0               0               69            62

  **S.D.**               0               0               1.3           4.6
  ----------- ---------- --------------- --------------- ------------- --------------

I-12

**APPENDIX I - INHALATION EXPOSURE DATA**

**TABLE I-3 - SUMMARY OF EXPOSURE DATA (CONT\'D)**

**GROUP 2 - 2000 MG/M^3^ TARGET CONCENTRATION**

  ----------- ---------- ----------- ---------------- --- ------ --- ------ -- ------ -- ------ -- ------ --------------- ------------- ----------
                         Nominal                                                                          Mean            Mean          Mean

              Exposure   Conc.       Hourly                                                               Concentration   Temperature   Relative
                                     Analytical                                                                                         
                                     Concentrations                                                                                     
                                     (mg/m^3^)                                                                                          

  Date        Number     (mg/m^3^)   1                    2          3         4         5         6      (mg/m^3^)       (^o^F)        Humidity
                                                                                                                                        (%)

  27-Apr-02   1          2088        2103                 2128       1891      1498      1733      1042   1733^a^         69            59

  28-Apr-02   2          2089        2159                 1916       2035      2017      1785      2032   1991            70            58

  29-Apr-02   3          1933        2135                 2215       2274      2203      2149      2099   2179            70            58

  30-Apr-02   4          1950        1923                 2066       2074      2090      2178      1970   2050            70            58

  1-May-02    5          2375        2020                 2049       1874      2263      2051      1615   1979            71            58

  2-May-02    6          2069        2101                 2269       1978      2092      1898      2120   2076            71            64

  3-May-02    7          1924        591                  2222       2393      2076      2064      2225   1929            72            61

  4-May-02    8          1736        1941                 2028       1968      1979      1969      2212   2016            71            61

  5-May-02    9          1924        2052                 1795       2064      1987      1913      1989   1967            74            52

  6-May-02    10         1896        1805                 2052       1937      1902      1819      1965   1913            71            69

  7-May-02    11         1981        2002\*               1972       2029      1964      1879      1946   1965            73            62

  8-May-02    12         1914        2022                 2058       1953      1867      1746      1812   1910            72            59

  9-May-02    13         1856        1875                 2117       2034      1943      1918      1905   1965            73            59

  10-May-02   14         1976        1992                 1963       1927      2113      2051      2085   2022            73            60

  11-May-02   15         1953        1915                 1777       1986      2037      1914      2019   1941            75            59
  ----------- ---------- ----------- ---------------- --- ------ --- ------ -- ------ -- ------ -- ------ --------------- ------------- ----------

a -- Low value due to problems with the rotameter

\* - Backup analytical system used

I-13

**APPENDIX I - INHALATION EXPOSURE DATA**

**TABLE I-3 - SUMMARY OF EXPOSURE DATA (CONT\'D)**

**GROUP 2 - 2000 MG/M^3^ TARGET CONCENTRATION**

  ----------- ---------- ----------- ---------------- -- ------ -- ------ -- ------ -- ------ -- ------ --------------- ------------- ----------
                         Nominal                                                                        Mean            Mean          Mean

              Exposure   Conc.       Hourly                                                             Concentration   Temperature   Relative
                                     Analytical                                                                                       
                                     Concentrations                                                                                   
                                     (mg/m^3^)                                                                                        

  Date        Number     (mg/m^3^)   1                   2         3         4         5         6      (mg/m^3^)       (^o^F)        Humidity
                                                                                                                                      (%)

  12-May-02   16         2032        2099                2099      2238      2110      2201      2058   2134            74            59

  13-May-02   17         1956        1797                2044      2035      2112      2004      1663   1943            74            59

  14-May-02   18         2018        2294                1988      2065      2048      1825      2238   2076            72            50

  15-May-02   19         2032        1964                2078      2081      2142      2082      1859   2034            72            57

  16-May-02   20         1969        2204                2131      2050      1623      1797      2089   1982            70            58

  17-May-02   21         2093        2016                1977      2051      2041      2104      1858   2008            70            58

  18-May-02   22         2244        1492                2346      1787      1858      2003      1966   1909            71            51

  19-May-02   23         1936        1893                1861      1759      1784      2054      2085   1906            72            58

  20-May-02   24         1988        2041                2177      2045      2073      1946      1912   2032            70            58

  21-May-02   25         2035        1939                2112      2119      2020      2094      1913   2033            69            56

  **MEAN**               1999                                                                           1988            72            58

  **S.D.**               124.2                                                                          87.7            1.7           3.8
  ----------- ---------- ----------- ---------------- -- ------ -- ------ -- ------ -- ------ -- ------ --------------- ------------- ----------

\* - Backup analytical system used

I-14

**APPENDIX I - INHALATION EXPOSURE DATA**

**TABLE I-3 - SUMMARY OF EXPOSURE DATA (CONT'D)**

**GROUP 3 - 10,000 MG/M^3^ TARGET CONCENTRATION**

  ----------- ---------- ----------- --------------- --- ------- --- ------- -- ------- -- ------- -- ------- --------------- ------------- ---------- ---
                         Nominal                                                                              Mean            Mean          Mean       

              Exposure   Conc.       Hourly                                                                   Concentration   Temperature   Relative   
                                     Analytical                                                                                                        
                                     Concentration                                                                                                     
                                     (mg/m^3^)                                                                                                         

  Date        Number     (mg/m^3^)   1                   2           3          4          5          6       (mg/m^3^)       (^o^F)        Humidity   
                                                                                                                                            (%)        

  27-Apr-02   1          10360       10533               10729       8758       10228      11168      10937   10392           71            58         

  28-Apr-02   2          9388        10829               9642        9711       11446      10142      11960   10622           74            51         

  29-Apr-02   3          10363       10510               11120       11077      10638      10446      10405   10699           74            47         

  30-Apr-02   4          10272       9950                9289        11872      10315      10541      10691   10443           73            58         

  1-May-02    5          10581       9829                10506       11152      10795      11065      11068   10736           75            49         

  2-May-02    6          10335       10172               10378       10258      10357      10393      10202   10293           75            54         

  3-May-02    7          10297       10000               10292       10727      10374      10522      9906    10304           76            50         

  4-May-02    8          9913        9753                10292       11027      7441       9886       10357   9793            74            59         

  5-May-02    9          10435       10748               10508       10788      10802      10290      10777   10652           75            53         

  6-May-02    10         10168       9746                9073        10210      9397       10114      10029   9762            75            61         

  7-May-02    11         10306       11503\*             10241       10112      10047      10012      9867    10297           76            57         

  8-May-02    12         10056       9346                9589        10209      9670       10041      10042   9816            75            58         

  9-May-02    13         10632       10227               10262       10671      10553      10346      10276   10389           75            57         

  10-May-02   14         10246       10185               9932        10648      10116      10135      10329   10224           76            55         

  11-May-02   15         10443       10078               10575       10666      10333      10090      10463   10367           76            55         
  ----------- ---------- ----------- --------------- --- ------- --- ------- -- ------- -- ------- -- ------- --------------- ------------- ---------- ---

\* - Backup analytical system used

I-15

**APPENDIX I - INHALATION EXPOSURE DATA**

**TABLE I-3 - SUMMARY OF EXPOSURE DATA (CONT\'D)**

**GROUP 3 - 10,000 MG/M^3^ TARGET CONCENTRATION**

  ----------- ---------- ----------- --------------- -- ------- -- ------- -- ------- -- ------- -- ------- --------------- ------------- ----------
                         Nominal                                                                            Mean            Mean          Mean

              Exposure   Conc.       Hourly                                                                 Concentration   Temperature   Relative
                                     Analytical                                                                                           
                                     Concentration                                                                                        
                                     (mg/m^3^)                                                                                            

  Date        Number     (mg/m^3^)   1                  2          3          4          5          6       (mg/m^3^)       (^o^F)        Humidity
                                                                                                                                          (%)

  12-May-02   16         10435       9945               9988       10161      10471      10579      10474   10270           75            61

  13-May-02   17         10364       9900               10068      10249      10655      10209      10309   10232           76            59

  14-May-02   18         10611       10147              10293      10392      10403      10649      10763   10441           76            47

  15-May-02   19         10646       9513               10424      10249      10989      10762      10595   10422           75            54

  16-May-02   20         10789       10412              10416      10719      10693      10660      10493   10565           75            52

  17-May-02   21         10606       10172              10584      10214      10408      10617      10591   10431           74            54

  18-May-02   22         10442       9100               9745       9832       9864       10150      10137   9805            74            50

  19-May-02   23         10763       9761               10432      11103      10674      10626      10993   10598           73            59

  20-May-02   24         10385       9866               10368      10566      10192      10133      9916    10173           73            53

  21-May-02   25         10628       10033              10466      10250      10716      10584      10647   10449           74            47

  **MEAN**               10379                                                                              10327           75            54

  **S.D.**               293.4                                                                              280.2           1.2           4.4
  ----------- ---------- ----------- --------------- -- ------- -- ------- -- ------- -- ------- -- ------- --------------- ------------- ----------

\* - Backup analytical system used

I-16

**APPENDIX I - INHALATION EXPOSURE DATA**

**TABLE I-3 - SUMMARY OF EXPOSURE DATA (CONT\'D)**

**GROUP 4 - 20,000 MG/M^3^ TARGET CONCENTRATION**

  ----------- ---------- ----------- --------------- -- ------- -- ------- -- ------- -- ------- -- ------- --------------- ------------- ---------- ---
                         Nominal                                                                            Mean            Mean          Mean       

              Exposure   Conc.       Hourly                                                                 Concentration   Temperature   Relative   
                                     Analytical                                                                                                      
                                     Concentration                                                                                                   
                                     (mg/m^3^)                                                                                                       

  Date        Number     (mg/m^3^)   1                  2          3          4          5          6       (mg/m^3^)       (^o^F)        Humidity   
                                                                                                                                          (%)        

  27-Apr-02   1          19922       21229              21107      20717      21913      22589      20845   21400           69            59         

  28-Apr-02   2          19743       20894              21824      21540      22071      21998      21550   21646           70            57         

  29-Apr-02   3          19524       21334              21752      21230      20981      20733      20689   21121           70            57         

  30-Apr-02   4          19432       19740              20830      21230      21195      22460      21550   21167           70            59         

  1-May-02    5          19547       20214              20531      21389      21281      21086      21404   20984           72            55         

  2-May-02    6          18992       18611              19921      19585      21056      21148      20743   20177           72            61         

  3-May-02    7          19390       20737              21288      21456      21500      21580      21358   21320           72            57         

  4-May-02    8          19208       20495              21303      20488      19770      20119      20664   20473           72            56         

  5-May-02    9          19501       20313              21205      20829      20625      20536      20107   20603           72            58         

  6-May-02    10         19035       19444              20189      20716      17551      20521      25144   20594           72            65         

  7-May-02    11         19501       19382\*            20626      20747      21406      19892      20576   20438           73            61         

  8-May-02    12         18799       18743              19573      20462      20183      20005      20638   19934           73            61         

  9-May-02    13         19921       20342              19990      20308      19972      18632      21216   20077           71            62         

  10-May-02   14         18965       19491              20230      20272      18387      20199      20133   19785           73            62         

  11-May-02   15         19547       15234              21088      20859      21692      20900      21095   20145           74            59         
  ----------- ---------- ----------- --------------- -- ------- -- ------- -- ------- -- ------- -- ------- --------------- ------------- ---------- ---

\* - Backup analytical system used

I-17

**APPENDIX I - INHALATION EXPOSURE DATA**

**TABLE I-3 - SUMMARY OF EXPOSURE DATA (CONT\'D)**

**GROUP 4 - 20,000 MG/M^3^ TARGET CONCENTRATION**

  ----------- ---------- ----------- --------------- -- ------- -- ------- -- ------- -- ------- -- ------- --------------- ------------- ----------
                         Nominal                                                                            Mean            Mean          Mean

              Exposure   Conc.       Hourly                                                                 Concentration   Temperature   Relative
                                     Analytical                                                                                           
                                     Concentration                                                                                        
                                     (mg/m^3^)                                                                                            

  Date        Number     (mg/m^3^)   1                  2          3          4          5          6       (mg/m^3^)       (^o^F)        Humidity
                                                                                                                                          (%)

  12-May-02   16         19274       18154              19894      20787      20241      22009      19513   20100           74            66

  13-May-02   17         19578       20298              19879      20010      19612      20170      20370   20057           74            61

  14-May-02   18         19531       19506              20204      20905      19819      20526      20542   20251           73            49

  15-May-02   19         19526       20123              20852      20415      20941      20783      20737   20642           73            54

  16-May-02   20         19350       18785              19978      20442      20500      20312      20954   20162           71            54

  17-May-02   21         19790       19989              20182      20241      20200      22775      20303   20615           71            58

  18-May-02   22         19551       20381              20949      20809      20550      20767      20439   20649           71            54

  19-May-02   23         19767       20283              18377      21781      21244      18671      21963   20386           71            58

  20-May-02   24         20071       19828              20809      21286      20966      21738      21454   21014           70            58

  21-May-02   25         19257       19289              20130      21021      16493      20883      20942   19793           70            54

  **MEAN**               19469                                                                              20541           72            58

  **S.D.**               314.5                                                                              518.3           1.4           3.8
  ----------- ---------- ----------- --------------- -- ------- -- ------- -- ------- -- ------- -- ------- --------------- ------------- ----------

I-18

**APPENDIX I - INHALATION EXPOSURE DATA**

**TABLE I-4 - SUMMARY OF DISTRIBUTION SAMPLES**

+---------------+-----------------+-----------------+----------------+
| **SAMPLE**    | **TARGET        |                 |                |
|               | EXPOSURE        |                 |                |
| **LOCATION**  | LEVELS**        |                 |                |
+---------------+-----------------+-----------------+----------------+
|               | **2000          | **10,000        | **20,000       |
|               | MG/M^3^**       | MG/M^3^**       | MG/M^3^**      |
+---------------+-----------------+-----------------+----------------+
| Left Top Back | 2073            | 10462           | 21155          |
+---------------+-----------------+-----------------+----------------+
| Left Top      | 1965            | 10636           | 21532          |
| Front         |                 |                 |                |
+---------------+-----------------+-----------------+----------------+
| Left Middle   | 2270            | 10385           | 20995          |
| Back          |                 |                 |                |
+---------------+-----------------+-----------------+----------------+
| Left Middle   | 2183            | 10507           | 21408          |
| Front         |                 |                 |                |
+---------------+-----------------+-----------------+----------------+
| Left Bottom   | 2184            | 10659           | 21124          |
| Back          |                 |                 |                |
+---------------+-----------------+-----------------+----------------+
| Left Bottom   | 1926            | 10373           | 21294          |
| Front         |                 |                 |                |
+---------------+-----------------+-----------------+----------------+
| Right Top     | 2135            | 10676           | 20832          |
| Back          |                 |                 |                |
+---------------+-----------------+-----------------+----------------+
| Right Top     | 2031            | 10526           | 21550          |
| Front         |                 |                 |                |
+---------------+-----------------+-----------------+----------------+
| Right Middle  | 1926            | 10997           | 21517          |
| Back          |                 |                 |                |
+---------------+-----------------+-----------------+----------------+
| Right Middle  | 1886            | 10903           | 21399          |
| Front         |                 |                 |                |
+---------------+-----------------+-----------------+----------------+
| Right Bottom  | 2162            | 10802           | 21026          |
| Back          |                 |                 |                |
+---------------+-----------------+-----------------+----------------+
| Right Bottom  | 1960            | 10401           | 20969          |
| Front         |                 |                 |                |
+---------------+-----------------+-----------------+----------------+
| MEAN          | 2058            | 10611           | 21233          |
+---------------+-----------------+-----------------+----------------+
| S.D.          | 126.79          | 206.70          | 248.71         |
+---------------+-----------------+-----------------+----------------+
| %CV           | 6.16            | 1.95            | 1.17           |
+---------------+-----------------+-----------------+----------------+
| Minimum       | 1886            | 10373           | 20832          |
+---------------+-----------------+-----------------+----------------+
| Maximum       | 2270            | 10997           | 21550          |
+---------------+-----------------+-----------------+----------------+

NOTE: Top, middle, bottom sample locations represent horizontal planes
within exposure chamber.

Left, right, front, back represent corners of each horizontal plane.
Samples taken in series approximately

8 minute intervals.

I-19

**APPENDIX I - INHALATION EXPOSURE DATA**

**TABLE I-5 LIGHTING, NOISE, AND OXYGEN LEVELS**

  ---------------------- ---------------- ---------------- ----------------
  **Environmental                                          
  Conditions**                                             

                         **April 27,      **May 8, 2002**  **May 21, 2002**
                         2002**                            

  **Light Intensity:                                       
  (fc)**                                                   

  Room PE103 in a cage 3 8.9              3.8              5.3
  feet above the floor.                                    

  Center of room PE 102  32.5             36.1             62
  3 feet above the                                         
  floor.                                                   

  Center of room PE 110  34.1             28.9             45.3
  3 feet above the                                         
  floor.                                                   

  **Noise level: (db)**                                    

  1m - 1: Door open      78.9             75.5             73.2

  1m - 1: Through port   79.7             76.9             77.1

  1m - 2: Door open      79.3             73.6             73.1

  1m - 2: Through port   80.2             77.1             76.5

  1m - 3: Door open      79.1             74.0             74.9

  1m - 3: Through port   80.1             76.8             77.2

  1m - 4: Door open      78.8             72.5             72.2

  1m - 4: Through port   79.9             75.2             75.1

  **O~2~ Level: (%)**                                      

  **(Reading upon        No Alarm         No Alarm         No Alarms
  removal)**                                               

  1m - 1                 20.7             20.3             19.9

  1m - 2                 20.7             20.4             20.2

  1m - 3                 20.7             20.3             19.7

  1m - 4                 20.7             20.2             19.9
  ---------------------- ---------------- ---------------- ----------------

> 1m-1, 1m-2, 1m-3, 1m-4 are exposure chamber designations.
>
> fc = foot candles (measured with an Omega HHLM-2 Light Meter)
>
> db = decibels (measured using an Omega HHSL-1 Sound Meter)
>
> \% = % oxygen (measured using a Biosystems Oxy Plus Single Sensor Gas
> Detector with an alarm at 19.5% O~2~)

I-20

**APPENDIX I - INHALATION EXPOSURE DATA**

**TABLE I-6 - PARTICLE SIZE DATA**

**^0\ MG/M^**3

+-----------------+-----------------+-----------------+-----------------+
| IMPACTOR        | STAGE CONSTANT  | FILTER WEIGHT   | PERCENT IN      |
|                 |                 |                 |                 |
| STAGE           | (μm)            | DIFFERENCE (μg) | SIZE RANGE      |
+-----------------+-----------------+-----------------+-----------------+
| FILTER          | 0.30            | 0               | 0               |
+-----------------+-----------------+-----------------+-----------------+
| 8               | 0.54            | 0               | 0               |
+-----------------+-----------------+-----------------+-----------------+
| 7               | 0.84            | 0               | 0               |
+-----------------+-----------------+-----------------+-----------------+
| 6               | 1.50            | 0               | 0               |
+-----------------+-----------------+-----------------+-----------------+
| 5               | 2.60            | 0               | 0               |
+-----------------+-----------------+-----------------+-----------------+
| 4               | 4.10            | 0               | 0               |
+-----------------+-----------------+-----------------+-----------------+
| 3               | 6.80            | 0               | 0               |
+-----------------+-----------------+-----------------+-----------------+
| 2               | 17.0            | 0               | 0               |
+-----------------+-----------------+-----------------+-----------------+
| 1               | 28.0            | 0               | 0               |
+-----------------+-----------------+-----------------+-----------------+
|                 |                 | TOTAL =0        |                 |
+-----------------+-----------------+-----------------+-----------------+
| PARTICLE        |                 |                 |                 |
| CONCENTRATION = |                 |                 |                 |
| 0 MG/M^3^       |                 |                 |                 |
+-----------------+-----------------+-----------------+-----------------+

PARTICLE SIZE DETERMINED WITH A SIERRA SERIES 210 CASCADE IMPACTOR

**CONDITIONS:**

SAMPLE FLOWRATE (Liters/Minute): 3 SAMPLE DURATION (Minutes): 3

**CALCULATION OF PARTICLE CONCENTRATION:**

SAMPLE VOLUME (Liters)= SAMPLE FLOW RATE\*SAMPLE DURATION

PARTICLE CONCENTRATION =

((TOTAL FILTER WEIGHT DIFFERENCE /1000 μg/mg)/(SAMPLE VOLUME))\*1000
L/M^3^

I-21

**APPENDIX I - INHALATION EXPOSURE DATA (CONT\'D)**

**TABLE I-6 - PARTICLE SIZE DATA (CONT\'D)**

**20,000 MG/M^3^ TARGET CONCENTRATION**

+-----------------+-----------------+-----------------+-----------------+
| IMPACTOR        | STAGE CONSTANT  | FILTER WEIGHT   | PERCENT IN      |
|                 |                 |                 |                 |
| STAGE           | (μm)            | DIFFERENCE (μG) | SIZE RANGE      |
+-----------------+-----------------+-----------------+-----------------+
| FILTER          | 0.30            | 0               | 0               |
+-----------------+-----------------+-----------------+-----------------+
| 8               | 0.54            | 10              | 5.6             |
+-----------------+-----------------+-----------------+-----------------+
| 7               | 0.84            | 70              | 38.9            |
+-----------------+-----------------+-----------------+-----------------+
| 6               | 1.50            | 0               | 0               |
+-----------------+-----------------+-----------------+-----------------+
| 5               | 2.60            | 50              | 27.8            |
+-----------------+-----------------+-----------------+-----------------+
| 4               | 4.10            | 40              | 22.2            |
+-----------------+-----------------+-----------------+-----------------+
| 3               | 6.80            | 0               | 0               |
+-----------------+-----------------+-----------------+-----------------+
| 2               | 17.0            | 0               | 0               |
+-----------------+-----------------+-----------------+-----------------+
| 1               | 28.0            | 10              | 5.6             |
+-----------------+-----------------+-----------------+-----------------+
|                 |                 | TOTAL =180      |                 |
+-----------------+-----------------+-----------------+-----------------+
| CONCENTRATION   |                 |                 |                 |
| OF PARTICLES =  |                 |                 |                 |
| 20 MG/M^3^      |                 |                 |                 |
|                 |                 |                 |                 |
| MEAN MEDIAN     |                 |                 |                 |
| AERODYNAMIC     |                 |                 |                 |
| DIAMETER =      |                 |                 |                 |
| 2.368 μm        |                 |                 |                 |
+-----------------+-----------------+-----------------+-----------------+

PARTICLE SIZE DETERMINED WITH A SIERRA SERIES 210 CASCADE IMPACTOR

**CONDITIONS:**

SAMPLE FLOWRATE (Liters/Minute): 3 SAMPLE DURATION (Minutes): 3

**CALCULATION OF PARTICLE CONCENTRATION:**

SAMPLE VOLUME (Liters) = SAMPLE FLOW RATE\*SAMPLE DURATION

PARTICLE CONCENTRATION =

((TOTAL FILTER WEIGHT DIFFERENCE /1000 μg/mg)/(SAMPLE VOLUME))\*1000
L/M^3^

I-22

**TABLE I-7 -- CHAMBER TEMPERATURES AND HUMIDITIES**

**CHAMBER TEMPERATURES (ºF) - 0 mg/m^3^ Target Concentration**

  ----------- ----------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----------
              **Time from                                                                                                                          
              Start of                                                                                                                             
              Exposure                                                                                                                             
              (Hours)**                                                                                                                            

              **0**       **0.5**    **1**      **1.5**    **2**      **2.5**    **3**      **3.5**    **4**      **4.5**    **5**      **5.5**    **6**

  27-Apr-02   ***64***    ***66***   ***66***   ***66***   68         68         68         68         68         68         68         68         68

  28-Apr-02   ***66***    68         68         68         68         68         68         68         68         68         68         68         68

  29-Apr-02   68          68         68         68         68         68         68         68         68         68         68         68         68

  30-Apr-02   ***66***    ***66***   68         68         68         68         68         68         68         68         68         68         68

  1-May-02    68          68         68         70         70         70         70         70         70         70         70         70         70

  2-May-02    68          68         68         68         68         68         68         68         70         70         70         70         70

  3-May-02    68          70         70         70         70         70         70         70         70         70         70         70         70

  4-May-02    68          68         68         68         68         68         68         68         68         68         68         68         68

  5-May-02    68          68         68         68         68         68         68         68         68         68         68         68         68

  6-May-02    ***64***    ***64***   68         68         70         70         70         70         70         70         70         70         70

  7-May-02    68          70         70         70         70         70         70         70         70         70         70         70         70

  8-May-02    ***66***    68         70         70         70         70         70         70         70         70         70         70         70

  9-May-02    68          70         70         70         70         70         70         70         70         70         70         70         70

  10-May-02   ***67***    69         69         70         70         70         70         70         70         70         70         70         70

  11-May-02   68          70         70         72         72         72         72         72         72         72         72         72         72

  12-May-02   68          68         70         70         70         70         70         70         70         70         70         70         70

  13-May-02   68          70         70         70         70         70         70         70         70         70         70         70         70

  14-May-02   68          70         70         70         70         70         70         70         70         70         70         70         70

  15-May-02   ***66***    68         68         68         70         70         70         70         70         68         68         68         68

  16-May-02   68          68         68         68         68         68         68         68         68         68         68         68         68

  17-May-02   68          68         68         68         68         68         68         68         68         68         68         68         68

  18-May-02   ***66***    ***66***   ***66***   68         68         68         68         68         68         68         68         68         68

  19-May-02   ***66***    68         68         68         68         68         68         68         68         68         68         68         68

  20-May-02   ***66***    ***66***   ***66***   ***66***   ***66***   ***66***   ***66***   ***66***   ***66***   ***66***   ***66***   ***66***   ***66***

  21-May-02   ***66***    ***66***   ***66***   ***66***   ***66***   ***66***   ***66***   ***66***   68         68         68         68         68

                                                                                                                                                   
  ----------- ----------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----------

I-23

**TABLE I-7 -- CHAMBER TEMPERATURES AND HUMIDITIES**

**CHAMBER TEMPERATURES (ºF) - 2000 mg/m^3^ Target Concentration**

  ----------- ----------- --------- ------- --------- ------- --------- -------- --------- -------- --------- -------- --------- --------
              **Time from                                                                                                        
              Start of                                                                                                           
              Exposure                                                                                                           
              (Hours)**                                                                                                          

              **0**       **0.5**   **1**   **1.5**   **2**   **2.5**   **3**    **3.5**   **4**    **4.5**   **5**    **5.5**   **6**

  27-Apr-02   ***66***    68        68      68        70      70        70       70        70       70        70       70        70

  28-Apr-02   68          70        70      70        70      70        70       70        70       70        70       70        70

  29-Apr-02   68          70        72      72        72      70        70       70        70       70        70       70        70

  30-Apr-02   68          70        70      70        70      70        70       70        70       70        70       70        70

  1-May-02    70          70        70      70        70      70        70       70        70       72        72       72        72

  2-May-02    70          70        70      70        70      70        70       70        72       72        72       72        72

  3-May-02    68          70        70      70        70      70        74       74        74       74        74       74        74

  4-May-02    70          70        71      71        71      71        71       71        71       71        71       71        71

  5-May-02    70          72        74      74        74      74        74       74        74       74        74       74        74

  6-May-02    ***66***    70        70      70        70      70        72       72        72       74        74       74        74

  7-May-02    70          70        72      72        72      72        74       74        74       74        74       74        74

  8-May-02    68          70        71      71        73      73        73       73        73       73        73       73        73

  9-May-02    68          72        72      72        72      72        72       74        74       74        74       74        74

  10-May-02   68          70        70      70        74      74        74       74        74       74        74       74        74

  11-May-02   70          72        74      74        74      **76**    **76**   **76**    **76**   **76**    **76**   **76**    **76**

  12-May-02   70          74        74      74        74      74        74       74        74       74        74       74        74

  13-May-02   70          70        72      74        74      74        **76**   **76**    **76**   **76**    74       **76**    **76**

  14-May-02   68          70        70      72        72      72        74       74        74       74        74       72        72

  15-May-02   68          70        72      72        74      74        72       74        74       70        72       72        72

  16-May-02   68          70        70      70        70      70        70       70        70       70        70       70        70

  17-May-02   68          70        70      70        70      70        70       70        70       72        72       72        72

  18-May-02   ***66***    70        70      71        72      72        72       72        72       72        72       72        72

  19-May-02   68          72        72      72        72      72        72       72        72       72        72       72        72

  20-May-02   ***66***    68        70      70        70      70        70       70        70       70        70       70        70

  21-May-02   ***66***    68        68      70        70      70        70       70        70       70        70       70        70

                                                                                                                                 
  ----------- ----------- --------- ------- --------- ------- --------- -------- --------- -------- --------- -------- --------- --------

I-24

**TABLE I-7 -- CHAMBER TEMPERATURES AND HUMIDITIES**

**CHAMBER TEMPERATURES (ºF) -- 10,000 mg/m^3^ Target Concentration**

  ----------- ----------- --------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----------
              **Time from                                                                                                                         
              Start of                                                                                                                            
              Exposure                                                                                                                            
              (Hours)**                                                                                                                           

              **0**       **0.5**   **1**      **1.5**    **2**      **2.5**    **3**      **3.5**    **4**      **4.5**    **5**      **5.5**    **6**

  27-Apr-02   ***66***    70        70         70         70         72         72         72         72         72         72         72         72

  28-Apr-02   70          72        74         74         74         74         74         74         74         74         74         74         74

  29-Apr-02   68          72        74         74         74         75         75         75         75         75         75         75         75

  30-Apr-02   68          70        72         72         74         74         74         74         74         74         74         74         74

  1-May-02    70          73        74         74         ***76***   ***76***   ***76***   ***76***   ***78***   ***76***   ***76***   ***76***   ***76***

  2-May-02    70          72        74         74         74         74         74         74         **78**     **78**     **78**     **78**     **78**

  3-May-02    68          72        74         ***76***   ***76***   ***76***   ***78***   ***78***   ***78***   ***78***   ***78***   ***78***   ***78***

  4-May-02    72          72        74         74         74         74         74         74         74         74         74         74         74

  5-May-02    70          72        74         ***76***   ***76***   ***76***   ***76***   ***76***   ***76***   ***76***   ***76***   ***76***   ***76***

  6-May-02    68          70        74         74         ***76***   ***76***   ***76***   ***76***   ***76***   ***78***   ***78***   ***78***   ***78***

  7-May-02    68          72        ***76***   ***76***   ***76***   ***76***   ***76***   ***78***   ***78***   ***78***   ***78***   ***78***   ***78***

  8-May-02    68          72        74         ***76***   ***76***   ***76***   ***76***   ***76***   ***76***   ***76***   ***76***   ***76***   ***76***

  9-May-02    68          72        74         74         74         74         74         ***78***   ***78***   ***78***   ***78***   ***78***   ***78***

  10-May-02   68          72        74         ***76***   ***76***   ***76***   ***78***   ***78***   ***78***   ***78***   ***78***   ***78***   ***78***

  11-May-02   68          72        ***76***   ***76***   ***78***   ***78***   ***78***   ***78***   ***78***   ***78***   ***78***   ***78***   ***78***

  12-May-02   70          74        ***76***   ***76***   ***76***   ***76***   ***76***   ***76***   ***76***   ***76***   ***76***   ***76***   ***76***

  13-May-02   68          72        ***76***   ***76***   ***78***   ***78***   ***78***   ***78***   ***78***   ***78***   ***78***   ***78***   ***78***

  14-May-02   68          72        74         ***76***   ***76***   ***76***   ***78***   ***78***   ***78***   ***78***   ***78***   ***78***   ***78***

  15-May-02   ***66***    72        74         ***76***   ***76***   ***76***   ***76***   ***78***   ***78***   ***76***   ***76***   ***76***   ***76***

  16-May-02   68          72        74         74         74         ***76***   ***76***   ***76***   ***76***   ***76***   ***76***   ***76***   ***76***

  17-May-02   68          70        74         74         74         74         ***76***   ***76***   ***76***   ***76***   ***76***   ***76***   ***76***

  18-May-02   ***66***    70        72         74         ***76***   ***76***   ***76***   ***76***   ***76***   ***76***   ***76***   ***76***   ***76***

  19-May-02   ***66***    70        74         74         74         74         74         74         74         74         74         74         74

  20-May-02   ***66***    70        72         72         74         74         74         74         74         74         74         74         74

  21-May-02   ***66***    70        72         74         74         74         74         74         ***76***   ***76***   ***76***   ***76***   ***76***

                                                                                                                                                  
  ----------- ----------- --------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----------

I-25

**TABLE I-7 -- CHAMBER TEMPERATURES AND HUMIDITIES**

**CHAMBER TEMPERATURES (ºF) -- 20,000 mg/m^3^ Target Concentration**

  ----------- ----------- ---------- ------- --------- ------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----------
              **Time from                                                                                                                   
              Start of                                                                                                                      
              Exposure                                                                                                                      
              (Hours)**                                                                                                                     

              **0**       **0.5**    **1**   **1.5**   **2**   **2.5**    **3**      **3.5**    **4**      **4.5**    **5**      **5.5**    **6**

  27-Apr-02   ***66***    68         68      68        70      70         70         70         70         70         70         70         70

  28-Apr-02   70          70         70      70        70      70         70         70         70         70         70         70         70

  29-Apr-02   68          70         70      70        70      70         70         70         70         70         70         70         70

  30-Apr-02   ***66***    68         70      70        70      70         70         70         70         70         70         70         70

  1-May-02    70          70         70      72        72      72         72         72         74         74         74         74         74

  2-May-02    68          70         70      70        70      72         72         72         74         74         74         74         74

  3-May-02    68          70         70      72        72      72         74         74         74         74         74         74         74

  4-May-02    ***66***    70         72      72        72      72         72         74         74         74         74         74         74

  5-May-02    70          70         72      72        72      72         72         72         72         72         72         72         72

  6-May-02    ***66***    ***66***   70      72        74      74         74         74         74         74         74         74         74

  7-May-02    68          70         72      72        72      74         74         74         74         74         74         74         74

  8-May-02    68          70         72      72        74      74         74         74         74         74         74         74         74

  9-May-02    ***66***    70         72      72        72      72         72         72         72         72         72         72         72

  10-May-02   ***66***    69         70      72        74      74         74         74         74         74         74         74         74

  11-May-02   ***66***    70         72      74        74      ***76***   ***76***   ***76***   ***76***   ***76***   ***76***   ***76***   ***76***

  12-May-02   69          73         74      74        74      74         74         74         74         74         74         74         74

  13-May-02   68          70         72      74        74      74         74         74         74         74         ***76***   ***76***   ***76***

  14-May-02   68          70         72      72        72      74         74         74         74         74         74         74         74

  15-May-02   ***66***    70         72      72        74      74         74         74         74         74         74         74         74

  16-May-02   68          70         70      70        70      72         72         72         72         72         72         72         72

  17-May-02   68          70         70      70        72      72         72         72         72         72         72         72         72

  18-May-02   ***66***    68         70      70        70      72         72         72         72         72         72         72         72

  19-May-02   ***66***    68         72      72        72      72         72         72         72         72         72         72         72

  20-May-02   ***66***    68         70      70        70      70         70         70         70         70         70         70         70

  21-May-02   ***66***    68         68      70        70      70         70         70         72         72         72         72         72

                                                                                                                                            
  ----------- ----------- ---------- ------- --------- ------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----------

I-26

**TABLE I-7 -- CHAMBER TEMPERATURES AND HUMIDITIES (CONT'D)**

**CHAMBER HUMIDITIES (%RH) - 0 mg/m^3^ Target Concentration**

  ----------- ----------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----------
              **Time from                                                                                                                          
              Start of                                                                                                                             
              Exposure                                                                                                                             
              (Hours)**                                                                                                                            

              **0**       **0.5**    **1**      **1.5**    **2**      **2.5**    **3**      **3.5**    **4**      **4.5**    **5**      **5.5**    **6**

  27-Apr-02   ***70***    ***62***   ***62***   ***62***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***

  28-Apr-02   ***62***    ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***

  29-Apr-02   55          55         55         55         55         55         55         55         55         55         55         55         55

  30-Apr-02   ***71***    ***71***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***

  1-May-02    ***64***    ***64***   ***64***   57         57         57         57         57         57         57         57         57         57

  2-May-02    ***64***    ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***

  3-May-02    ***64***    57         57         57         57         57         57         57         57         57         57         57         57

  4-May-02    ***64***    ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***

  5-May-02    ***64***    ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***

  6-May-02    ***100***   ***90***   ***76***   ***72***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***

  7-May-02    ***72***    ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***

  8-May-02    ***71***    ***72***   ***60***   ***60***   ***60***   ***60***   ***60***   ***60***   ***60***   ***60***   ***60***   ***60***   ***60***

  9-May-02    ***64***    57         57         57         57         57         57         57         57         57         57         57         57

  10-May-02   ***71***    ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***

  11-May-02   ***72***    ***64***   ***64***   ***57***   ***65***   ***65***   ***65***   ***65***   ***65***   ***65***   ***65***   ***65***   ***65***

  12-May-02   ***72***    ***72***   ***68***   ***68***   ***68***   ***68***   ***68***   ***68***   ***68***   ***68***   ***68***   ***68***   ***68***

  13-May-02   ***72***    ***72***   ***72***   ***72***   ***72***   ***72***   ***72***   ***72***   ***72***   ***72***   ***72***   ***72***   ***72***

  14-May-02   55          57         48         48         48         48         48         57         ***64***   ***64***   ***64***   57         57

  15-May-02   ***62***    ***64***   ***64***   ***64***   57         57         57         57         57         64         64         64         64

  16-May-02   ***64***    ***64***   ***64***   ***64***   55         55         55         55         55         55         55         55         55

  17-May-02   ***64***    ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***

  18-May-02   ***62***    ***62***   ***62***   ***55***   55         55         55         55         55         55         ***64***   ***64***   ***64***

  19-May-02   ***71***    ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***

  20-May-02   ***62***    ***62***   ***62***   ***62***   ***71***   ***71***   ***62***   ***62***   ***62***   ***62***   ***62***   ***62***   ***62***

  21-May-02   53          53         53         53         53         53         53         53         55         55         55         55         55

                                                                                                                                                   
  ----------- ----------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----------

I-27

**TABLE I-7 -- CHAMBER TEMPERATURES AND HUMIDITIES (CONT'D)**

**CHAMBER HUMIDITIES (%RH) - 2000 mg/m^3^ Target Concentration**

  ----------- ----------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----------
              **Time from                                                                                                                          
              Start of                                                                                                                             
              Exposure                                                                                                                             
              (Hours)**                                                                                                                            

              **0**       **0.5**    **1**      **1.5**    **2**      **2.5**    **3**      **3.5**    **4**      **4.5**    **5**      **5.5**    **6**

  27-Apr-02   ***62***    ***64***   ***64***   ***64***   57         57         57         57         57         57         57         57         57

  28-Apr-02   ***64***    57         57         57         57         57         57         57         57         57         57         57         57

  29-Apr-02   **64**      57         50         50         50         48         48         48         48         48         48         48         48

  30-Apr-02   ***64***    57         57         57         57         57         57         57         57         57         57         57         57

  1-May-02    ***64***    57         57         57         57         57         57         57         57         57         57         57         57

  2-May-02    ***64***    ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***64***   ***65***   ***65***   ***65***   ***65***   ***65***

  3-May-02    ***64***    ***64***   ***64***   ***64***   ***64***   ***64***   58         58         58         58         58         58         58

  4-May-02    ***64***    ***64***   60         60         60         60         60         60         60         60         60         60         60

  5-May-02    ***64***    57         51         51         51         51         51         51         51         51         51         51         51

  6-May-02    ***90***    ***76***   ***76***   ***76***   ***76***   ***76***   ***65***   ***65***   ***65***   58         58         58         58

  7-May-02    ***64***    ***72***   ***65***   ***65***   ***65***   ***65***   58         58         58         58         58         58         58

  8-May-02    ***72***    57         57         57         58         58         58         58         58         58         58         58         58

  9-May-02    ***72***    57         57         57         57         57         57         58         58         58         58         58         58

  10-May-02   ***72***    ***64***   ***64***   ***64***   58         58         58         58         58         58         58         58         58

  11-May-02   ***64***    ***65***   58         58         58         52         59         59         59         59         59         59         59

  12-May-02   ***68***    58         58         58         58         58         58         58         58         58         58         58         58

  13-May-02   ***72***    ***72***   ***65***   58         58         58         52         52         52         52         ***66***   52         52

  14-May-02   55          48         57         50         50         50         44         44         44         51         51         50         50

  15-May-02   55          57         57         57         51         51         57         58         58         ***64***   57         57         57

  16-May-02   ***64***    57         57         57         57         57         57         57         57         57         57         57         57

  17-May-02   ***64***    57         57         57         57         57         57         57         ***64***   57         57         57         57

  18-May-02   ***62***    52         52         53         50         50         50         50         50         50         50         50         50

  19-May-02   ***64***    57         57         57         57         57         57         57         57         57         57         57         57

  20-May-02   ***62***    ***64***   57         57         57         57         57         57         57         57         57         57         57

  21-May-02   53          55         55         57         57         57         57         57         57         57         57         57         57

                                                                                                                                                   
  ----------- ----------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----------

I-28

**TABLE I-7 -- CHAMBER TEMPERATURES AND HUMIDITIES (CONT'D)**

**CHAMBER HUMIDITIES (%RH) -- 10,000 mg/m^3^ Target Concentration**

  ----------- ----------- ---------- ------- --------- ------- --------- ------- --------- ------- --------- ------- --------- -------
              **Time from                                                                                                      
              Start of                                                                                                         
              Exposure                                                                                                         
              (Hours)**                                                                                                        

              **0**       **0.5**    **1**   **1.5**   **2**   **2.5**   **3**   **3.5**   **4**   **4.5**   **5**   **5.5**   **6**

  27-Apr-02   ***71***    57         57      57        57      57        57      57        57      57        57      57        57

  28-Apr-02   57          50         51      51        51      51        51      51        51      51        51      51        51

  29-Apr-02   ***64***    57         51      51        51      42        42      42        42      42        42      42        42

  30-Apr-02   ***64***    ***64***   57      57        57      57        57      57        57      57        57      57        57

  1-May-02    ***64***    54         51      51        45      45        45      45        46      49        49      49        49

  2-May-02    ***64***    ***61***   58      58        58      58        58      58        46      46        46      46        46

  3-May-02    ***64***    57         51      52        52      52        46      46        46      46        46      46        46

  4-May-02    ***61***    ***65***   58      58        58      58        58      58        58      58        58      58        58

  5-May-02    ***64***    57         51      52        52      52        52      52        52      52        52      52        52

  6-May-02    ***90***    ***77***   58      58        59      59        59      59        59      53        53      53        53

  7-May-02    ***64***    ***65***   59      59        59      59        59      53        53      53        53      53        53

  8-May-02    ***72***    ***65***   58      56        56      56        56      56        56      56        56      56        56

  9-May-02    ***64***    ***65***   58      58        58      58        58      53        53      53        53      53        53

  10-May-02   ***64***    53         54      56        56      56        53      53        53      53        53      53        53

  11-May-02   ***64***    ***65***   52      52        53      53        53      53        53      53        53      53        53

  12-May-02   ***72***    ***66***   59      59        59      59        59      59        59      59        59      59        59

  13-May-02   ***72***    ***73***   59      59        53      53        53      53        53      60        60      60        60

  14-May-02   ***64***    50         44      45        45      45        45      45        45      46        46      45        45

  15-May-02   ***71***    57         58      52        52      52        52      53        53      52        52      52        52

  16-May-02   ***64***    57         51      51        51      45        45      52        52      52        52      52        52

  17-May-02   ***64***    57         51      51        58      58        52      52        52      52        52      52        52

  18-May-02   ***62***    57         53      47        45      45        45      45        45      45        52      52        52

  19-May-02   ***71***    ***64***   58      58        58      58        58      58        58      58        58      58        58

  20-May-02   ***62***    57         57      57        51      51        51      51        51      51        51      51        51

  21-May-02   53          57         50      44        44      44        44      44        45      45        45      45        45

                                                                                                                               
  ----------- ----------- ---------- ------- --------- ------- --------- ------- --------- ------- --------- ------- --------- -------

I-29

**TABLE I-7 -- CHAMBER TEMPERATURES AND HUMIDITIES (CONT'D)**

**CHAMBER HUMIDITIES (%RH) -- 20,000 mg/m^3^ Target Concentration**

  ----------- ----------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----------
              **Time from                                                                                                                          
              Start of                                                                                                                             
              Exposure                                                                                                                             
              (Hours)**                                                                                                                            

              **0**       **0.5**    **1**      **1.5**    **2**      **2.5**    **3**      **3.5**    **4**      **4.5**    **5**      **5.5**    **6**

  27-Apr-02   ***62***    ***64***   ***64***   ***64***   57         57         57         57         57         57         57         57         57

  28-Apr-02   57          57         57         57         57         57         57         57         57         57         57         57         57

  29-Apr-02   55          57         57         57         57         57         57         57         57         57         57         57         57

  30-Apr-02   ***71***    ***64***   57         57         57         57         57         57         57         57         57         57         57

  1-May-02    57          57         57         57         57         57         57         57         51         51         51         51         51

  2-May-02    ***72***    ***64***   ***64***   ***64***   ***64***   57         57         57         58         58         58         58         58

  3-May-02    ***64***    57         ***64***   57         57         57         51         51         51         58         58         58         58

  4-May-02    ***71***    ***64***   57         57         57         57         57         51         51         51         51         51         51

  5-May-02    57          ***64***   57         57         57         57         57         57         57         57         57         57         57

  6-May-02    ***90***    ***90***   ***77***   ***69***   58         58         58         58         58         58         58         58         58

  7-May-02    ***64***    ***72***   57         ***65***   ***65***   58         58         58         58         58         58         58         58

  8-May-02    ***72***    ***72***   ***65***   ***65***   58         58         58         58         58         58         58         58         58

  9-May-02    ***62***    ***64***   57         57         57         57         57         ***65***   ***65***   ***65***   ***65***   ***65***   ***65***

  10-May-02   ***71***    ***72***   ***72***   ***65***   58         58         58         58         58         58         58         58         58

  11-May-02   ***71***    ***72***   ***65***   58         58         56         59         52         52         52         52         59         59

  12-May-02   ***64***    ***69***   ***66***   ***66***   ***66***   ***66***   ***66***   ***66***   ***66***   ***66***   ***66***   ***66***   ***66***

  13-May-02   ***72***    ***72***   ***65***   58         58         58         58         58         58         58         59         59         59

  14-May-02   55          57         50         50         50         44         44         44         44         51         51         51         51

  15-May-02   ***62***    **64**     57         57         51         51         51         51         51         51         51         51         51

  16-May-02   ***64***    **57**     57         57         57         50         50         50         50         50         50         57         57

  17-May-02   ***64***    **57**     57         57         57         57         57         57         57         57         57         57         57

  18-May-02   ***62***    **55**     57         57         57         50         50         50         50         50         50         57         57

  19-May-02   ***62***    **64**     57         57         57         57         57         57         57         57         57         57         57

  20-May-02   ***62***    **64**     57         57         57         57         57         57         57         57         57         57         57

  21-May-02   53          55         55         57         57         57         57         57         50         50         50         50         50
  ----------- ----------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----------

I-30

**APPENDIX J - ANALYTICAL CHEMISTRY REPORT**

**SUMMARY**

Charcoal tube sorbent tube samples were received by the Analytical
Chemistry Laboratory from inhalation chamber exposures and were
characterized for hydrocarbon distribution using capillary gas
chromatography with flame ionization detection (GC/FID). Sorbent tube
samples were stored in a freezer pending analysis.

**SAMPLE PREPARATION**

The front and back sections of each charcoal sample tube were desorbed
and analyzed separately to

assess potential sampling breakthrough. The charcoal tube sections were
desorbed with 3.0 mL carbon disulfide (CS~2~) for at least 30 minutes.
Aliquots were then analyzed by GC-FID.

**STANDARDIZATION**

A standard mixture was prepared in CS~2~ containing each of the 18
target hydrocarbons plus ETBE oxygenate. Analysis of the standard
mixture was used to confirm the relative retention times of each target
hydrocarbon and was not used for quantitative purposes.

**CHARACTERIZATION**

Characterization of the neat MRD-00-716 (gasoline vapor condensate with
ETBE) was performed separately and will be reported as part of EMBSI
Study 167490. Neat test substance characterization included a similar
analysis of the relative distribution of target hydrocarbons and
oxygenate as was performed for the chamber sorbent tube samples.

J-1

**APPENDIX J - ANALYTICAL CHEMISTRY REPORT**

**INSTRUMENT CONDITIONS FOR MRD-00-716**

**ON CHARCOAL SORBENT TUBE**

The following GC conditions and equipment were used to determine the
hydrocarbon distribution of test substance on chamber characterization
sorbent tubes:

  ------------------------------ ----------------------------------------
  GC                             Perkin Elmer XL Autosystem

  FID Range                      FID (2\^5)

  Detector Temperature; (gas     225°C (H~2~ 45 mL/min; Air 450 mL/min)
  flows)                         

  Injector Temperature (Split    225°C (split injection 20:1)
  ratio)                         

  Injection Volume               0.2µL or 0.5µL\*

  Analytical Column              Supleco Petrocol DH 150 fused silica
                                 capillary column (150m x 0.25mm; 1.0µm
                                 film thickness)

  Oven Temperature Program       35°C (hold 130 minutes); ramp @
                                 2°C/minute to 200°C

  Data Collection                Perkin Elmer Nelson Turbochrom (TC4)
                                 version 4.1.2

  Carrier Gas Program            65 psi (He)
  ------------------------------ ----------------------------------------

\*0.2µL injected of 10,000mg/m^3^ and 20,000mg/m^3^ samples, 0.5µL
injected of 2000mg/m^3^ samples.

**RESULTS**

Hydrocarbon characterization was performed on an area percent basis for
each of the 18

target hydrocarbons and ETBE oxygenate. Results are listed in Table J-1.

The relative distribution of hydrocarbons and oxygenate measured on the
chamber characterization charcoal tubes was in good agreement with that
measured in the characterization of neat MRD-00-716 test substance.

D. J. Letinski Date

Analytical Chemist

J-2

**APPENDIX J - ANALYTICAL CHEMISTRY REPORT**

  --------------------- -------------------- ---------------------- ---------------------- -------------------- ---------------------- ---------------------- -------------------- ----------- ---------------------- ---- ---------------------- ----- -------------------- ----------- ---------------------- ---- ---------------------- ----
  **TABLE J - 1**                                                                                                                                                                                                                                                                                                                           

                                                                                                                                                                                                                                                                                                                                            

  **MRD-00-716 CHAMBER                                                                                                                                                                                                                                                                                                                      
  CHARACTERIZATION -                                                                                                                                                                                                                                                                                                                        
  SORBENT TUBES                                                                                                                                                                                                                                                                                                                             
  HYDROCARBON                                                                                                                                                                                                                                                                                                                               
  DISTRIBUTION**                                                                                                                                                                                                                                                                                                                            

                                                                                                                                                                                                                                                                                                                                            

  Sample Date           30-Apr-02                                                          8-May-02                                                                                14-May-02                                                                                 21-May-02                                                      

  Inhalation ID         1                    2                      3                      4                    5                      6                                           7                                  8                           *9*                        10                                 11                          12

                        mg/m^3^                                                            mg/m^3^                                                                                 mg/m^3^                                                                                   mg/m^3^                                                        

                        [2000]{.underline}   [10,000]{.underline}   [20,000]{.underline}   [2000]{.underline}   [10,000]{.underline}   [20,000]{.underline}   [2000]{.underline}               [10,000]{.underline}        [20,000]{.underline}         [2000]{.underline}               [10,000]{.underline}        [20,000]{.underline}   

  Compound              *RESULTS ARE in                                                                                                                                                                                                                                                                                                     
                        \"AREA %\" of TARGET                                                                                                                                                                                                                                                                                                
                        HYDROCARBONS*                                                                                                                                                                                                                                                                                                       

  isobutane             1.7                  1.5                    1.7                    1.8                  1.7                    1.6                    1.7                              1.7                         1.7                          1.7                              1.6                         1.7                    

  n-butane              9.6                  8.7                    9.7                    10.0                 9.6                    9.4                    9.5                              9.7                         9.5                          9.7                              9.3                         9.6                    

  isopentane            31.8                 32.1                   32.6                   32.5                 32.7                   32.6                   32.2                             32.3                        32.6                         32.4                             32.1                        33.1                   

  n-pentane             9.8                  10.0                   9.9                    9.9                  10.0                   10.0                   9.8                              9.9                         10.0                         9.9                              9.9                         10.1                   

  trans-2-pentene       2.2                  2.2                    2.2                    2.2                  2.2                    2.2                    2.1                              2.2                         2.2                          2.2                              2.2                         2.2                    

  2-methyl-2-butene     3.2                  3.3                    3.2                    3.2                  3.2                    3.2                    3.2                              3.2                         3.2                          3.2                              3.2                         3.3                    

  2,3-dimethylbutane    1.7                  1.5                    1.7                    1.5                  1.5                    1.5                    1.7                              1.7                         1.5                          1.5                              1.7                         1.5                    

  2-methylpentane       4.9                  5.0                    4.9                    4.8                  4.9                    4.9                    4.9                              4.9                         4.9                          4.9                              4.9                         4.9                    

  3-methylpentane       3.1                  3.2                    3.1                    3.1                  3.1                    3.1                    3.1                              3.1                         3.1                          3.1                              3.1                         3.1                    

  n-hexane              2.6                  2.7                    2.6                    2.6                  2.6                    2.6                    2.6                              2.6                         2.6                          2.6                              2.6                         2.6                    

  ETBE                  17.1                 17.6                   16.9                   16.6                 17.0                   17.2                   17.1                             17.1                        17.1                         16.9                             17.4                        16.9                   

  methylcyclopentane    1.4                  1.4                    1.3                    1.3                  1.4                    1.4                    1.4                              1.4                         1.4                          1.3                              1.4                         1.3                    

  2,4-dimethylpentane   1.1                  1.2                    1.1                    1.1                  1.1                    1.1                    1.1                              1.1                         1.1                          1.1                              1.1                         1.1                    

  benzene               2.2                  2.0                    1.9                    2.2                  1.9                    1.9                    2.2                              1.9                         1.9                          2.2                              1.9                         1.9                    

  2-methylhexane        1.2                  1.3                    1.2                    1.2                  1.2                    1.2                    1.2                              1.2                         1.2                          1.2                              1.2                         1.1                    

  2,3-dimethylpentane   1.3                  1.3                    1.2                    1.2                  1.2                    1.2                    1.2                              1.2                         1.3                          1.2                              1.3                         1.2                    

  3-methylhexane        1.4                  1.4                    1.4                    1.4                  1.3                    1.4                    1.4                              1.3                         1.4                          1.4                              1.4                         1.3                    

  isooctane             1.5                  1.6                    1.4                    1.4                  1.4                    1.5                    1.4                              1.3                         1.5                          1.5                              1.5                         1.3                    

  toluene               [2.3]{.underline}    [2.3]{.underline}      [2.1]{.underline}      [2.2]{.underline}    [2.1]{.underline}      [2.1]{.underline}      [2.3]{.underline}                [2.1]{.underline}           [2.1]{.underline}            [2.2]{.underline}                [2.3]{.underline}           [1.9]{.underline}      

  Sum                   100                  100                    100                    100                  100                    100                    100                              100                         100                          100                              100                         100                    

  No hydrocarbon target                                                                                                                                                                                                                                                                                                                     
  compounds were                                                                                                                                                                                                                                                                                                                            
  detected on the back                                                                                                                                                                                                                                                                                                                      
  section of the                                                                                                                                                                                                                                                                                                                            
  sorbent tubes                                                                                                                                                                                                                                                                                                                             
  analyzed.                                                                                                                                                                                                                                                                                                                                 
  --------------------- -------------------- ---------------------- ---------------------- -------------------- ---------------------- ---------------------- -------------------- ----------- ---------------------- ---- ---------------------- ----- -------------------- ----------- ---------------------- ---- ---------------------- ----

J-3

**APPENDIX K -- STATISTICIAN'S REPORT**

Analysis Of Fetal Data From A Whole-Body Inhalation Developmental
Toxicity

Study In Rats With Baseline Gasoline with ETBE Vapor Condensate
(MRD-00-713)

This report details the statistical analysis of fetal body weight and
anomaly data from ExxonMobil Study 171634. The study was conducted to
evaluate the potential developmental toxicity of Baseline Gasoline with
ETBE Vapor Condensate (GEVC). GEVC was administered via whole-body
inhalation exposure to pregnant rats during the period of major
organogenesis and fetal growth. GEVC was administered by whole-body
inhalation exposure to 25 confirmed-mated Crl: CD^®^(SD) IGSBR female
rats at target doses of 0 (air control) 2000, 10,000, and 20,000 mg/m^3^
for six hours (plus the theoretical equilibration time) daily from
Gestation Day (GD) 5 through GD 20.

The fetal body weight was analyzed by a mixed model analysis of variance
that provided an accurate statistical model of the biology. The analysis
used the litter as the basis for analysis and effectively used the
litter size as a covariate. The model considered dose group, litter
size, and fetal sex as explanatory variables. When the overall effect of
dose, or the dose by sex effect, was statistically significant the dose
groups means were tested pairwise vs. the control group using least
squares means. The least squares means allowed comparisons that
accounted for differences in litter size and sex. The mathematical model
is based on a paper by Chen, et al (1996). The analysis was run using
SAS with code suggested in Little, et al (1997).

The analysis of anomalies (malformations, variations, or observations)
was based on a Generalized Estimating Equation (GEE) application of the
linearized model, Ryan (1992). The model used the litter as the basis
for analysis and considered correlation among littermates by
incorporating an estimated constant correlation and the litter size as a
covariate. When the overall effect of dose, or the dose by sex effect,
was statistically significant the dose groups were tested pairwise vs.
the control group using least squares means. The least squares means
allows comparisons that account for differences in litter size. There
were three categories of anomalies tested, and within each category
specific anomalies were also tested. In addition to the category
specific anomalies a series of combined analyses were performed within
each category:

Combined Malformations and Variations for All Fetuses

Combined Malformations and Variations for Alive Fetuses

Combined Malformations and Variations for Dead Fetuses

Malformations for All Fetuses

Malformations for Alive Fetuses

Malformations for Dead Fetuses

Variations for All Fetuses

Variations for Alive Fetuses

Variations for Dead Fetuses

In some cases there were no dead fetuses in a category.

K-1

**APPENDIX K -- STATISTICIAN'S REPORT (CONT'D)**

Table I lists the four categories and corresponding sub-categories.
Within each category several subcategories were combined into a group of
similar anomalies. For example in the Category Skeletal the separate
sub-categories of "SKELETAL/RIBS (C7): Cervical rib; Bilateral",
"SKELETAL/RIBS: Rudimentary supernumerary ribs", and "SKELETAL/RIBS
(L1): Well-formed; Left" were combined into a sub-category
"SKELETAL/RIBS: supernumerary Ribs(combined)". In this combined category
an animal is counted once when he, or she, exhibits more than one
characteristic. The sub-categories that were combined are listed in the
Sub-categories Combined column of Table 1 by the sub-category number.
The analyses were run using SAS.

Table I

Anomaly Categories and Corresponding Sub-categories

  -------------- ------------------------------------------- ------------------
  **Category**   **Sub-Category**                            **Sub-categories
                                                             combined**

  Head           1- HEAD: Anolphthalmia; Bilateral           

                 2- HEAD: Dilated lateral ventricles;        
                 Bilateral                                   

                 3- HEAD: Open eye; Right                    

                 4- HEAD: Retina fold                        

  External       1- EXTERNAL: Acaudate                       

                 2- EXTERNAL: Anal atresia                   

                 3- EXTERNAL: Anasarca                       

                 4- EXTERNAL: Brachydactyly; all paws        

                 5- EXTERNAL: Conjoined twin; Joined at      
                 thoracic region; **1** head, **8** limbs,   
                 **2** tails, **1** umbilicus                

                 6- EXTERNAL: Domed head                     

                 7- EXTERNAL: Ectrodactyly; all paws         

                 8- EXTERNAL: Kyphosis                       

                 9- EXTERNAL: Malrotated hindpaw; Left       

                 10- EXTERNAL: Small eye bulge; Bilateral    
  -------------- ------------------------------------------- ------------------

K-2

**APPENDIX K -- STATISTICIAN'S REPORT (CONT'D)**

Table I

Malformation Categories and Corresponding Sub-categories

  ---------------- ------------------------------------------- ------------------
  Abdomen/Thorax   1- ABDOMEN/THORAX: All other abdominal      
                   organs appear on each side                  

                   2- ABDOMEN/THORAX: All thoracic and cranial 
                   organs shared                               

                   3- ABDOMEN/THORAX: Cecum not evident;       
                   bifurcation appears in area where cecum     
                   would normally reside                       

                   4- ABDOMEN/THORAX: Double aorta             

                   5- ABDOMEN/THORAX: Duplicate tongue         

                   6- ABDOMEN/THORAX: Elongated innominate     
                   artery                                      

                   7- ABDOMEN/THORAX: Enlarged atrial chamber; 
                   Right                                       

                   8- ABDOMEN/THORAX: Hydronephrosis           

                   9- ABDOMEN/THORAX: Hydroureter              

                   10- ABDOMEN/THORAX: Innominate artery       
                   absent                                      

                   11- ABDOMEN/THORAX: Liver, stomach, spleen, 
                   entire small intestine shared               

                   12- ABDOMEN/THORAX: Malpositioned carotid   

                   13- ABDOMEN/THORAX: Malpositioned carotid   
                   and subclavian branches; Bilateral          

                   14- ABDOMEN/THORAX: Malpositioned kidneys   

                   15- ABDOMEN/THORAX: Malpositioned ovaries   

                   16- ABDOMEN/THORAX: Malpositioned pulmonary 
                   artery branch                               

                   17- ABDOMEN/THORAX: Malpositioned           
                   subclavian branch; Right                    

                   18- ABDOMEN/THORAX: Malpositioned uterus    

                   19- ABDOMEN/THORAX: Misshapen spleen        

                   20- ABDOMEN/THORAX: No cervical spinal      
                   column                                      

                   21- ABDOMEN/THORAX: Spleen small            

                   22- ABDOMEN/THORAX: Supernumerary lung      
                   lobe; Left                                  

                   23- ABDOMEN/THORAX: Umbilical artery        
                   aneurysm                                    

                   24- ABDOMEN/THORAX: Umbilical artery arises 
                   from left side of urinary bladder           

                   25- ABDOMEN/THORAX: Ventricle small; Left   

                   26- ABDOMEN/THORAX: Abnormal spleen         19,21

                   27- ABDOMEN/THORAX: Abnormal                6,10,13,12,16,17
                   thoracic/cervical blood vessels             

                   28- ABDOMEN/THORAX: Malpositioned           14,15,18
                   urogenital organs                           
  ---------------- ------------------------------------------- ------------------

K-3

**APPENDIX K -- STATISTICIAN'S REPORT (CONT'D)**

Table I

Malformation Categories and Corresponding Sub-categories

  ---------- ----------------------------------------------------------- -------------
  Skeletal   1- SKELETAL/FORELIMB (All bones ): Duplication or extra     
             bones                                                       

             2- SKELETAL/FOREPAW (All bones): Duplication or extra bones 

             3- SKELETAL/FOREPAW (Metacarpal **1** anlage): Misshapen;   
             Left                                                        

             4- SKELETAL/FOREPAW (Proximal phalanges **2**-**4**):       
             Unossified; Bilateral                                       

             5- SKELETAL/HINDLIMB (All bones): Duplication or extra      
             bones; Bilateral                                            

             6- SKELETAL/HINDPAW (All bones): Duplication or extra       
             bones; Bilateral                                            

             7- SKELETAL/HINDPAW (Calcaneus): Advanced; Bilateral        

             8- SKELETAL/PECTORAL GIRDLE (All bones): Duplication or     
             extra bones; Bilateral                                      

             9- SKELETAL/PELVIC GIRDLE (All bones): Duplication or extra 
             bones; Bilateral                                            

             10- SKELETAL/RIBS (All bones): Duplication or extra bones   

             11- SKELETAL/RIBS (C7 and T1 Anlage): Fused; Anlage on C7   
             and T1 rib fused before it meets sternebrae                 

             12- SKELETAL/RIBS (C7, C7 Anlage): Cervical rib; Bilateral  

             13- SKELETAL/RIBS (L1): Well-formed; Left                   

             14- SKELETAL/RIBS (Right twin T8 left, Left twin T8 right): 
             Fused; Left                                                 

             15- SKELETAL/RIBS (T13): Short last rib; Right              

             16- SKELETAL/RIBS: Rudimentary supernumerary ribs           

             17- SKELETAL/SKULL (Interparietal): Misshapen               

             18- SKELETAL/SKULL (Squamosal Process): Hypoplastic; Left   

             19- SKELETAL/SKULL                                          
             (Supraoccipital,Interparietal,Parietals,Frontals,Nasals):   
             Duplication or extra bone                                   

             20- SKELETAL/SKULL (Tympanics): Hypoplastic                 

             21- SKELETAL/STERNEBRAE (All bones): Duplication or extra   
             bones                                                       

             22- SKELETAL/STERNEBRAE (VI): Advanced                      

             23- SKELETAL/STERNEBRAE: Asymmetric sternebrae              

             24- SKELETAL/STERNEBRAE: Bifid sternebrae                   

             25- SKELETAL/STERNEBRAE: Dumbbell-shaped sternebrae         

             26- SKELETAL/STERNEBRAE: Hypoplastic sternebrae             

             27- SKELETAL/STERNEBRAE: Misshapen sternebrae               

             28- SKELETAL/STERNEBRAE: Unossified sternebrae              

             29- SKELETAL/VERTEBRAE (All bones): Duplication or extra    
             bones                                                       

             30- SKELETAL/VERTEBRAE (CE3 Anlage): Bifid centra           

             31- SKELETAL/VERTEBRAE (L): One less presacral vertebrae    

             32- SKELETAL/VERTEBRAE (L1): Misshapen centra               

             33- SKELETAL/VERTEBRAE (Left twin CE **1**-**7**): Fused    

             34- SKELETAL/VERTEBRAE (Left twin T2): Unossified centra    

             35- SKELETAL/VERTEBRAE (Left twin T3): Hemicentra           

             36- SKELETAL/VERTEBRAE: Bifid vertebral centra              

             37- SKELETAL/VERTEBRAE: Dumbbell-shaped vertebral centra    

             38- SKELETAL/VERTEBRAE: Dumbbell-shaped vertebral centra    
             anlage                                                      

             39- SKELETAL/RIBS: Supernumerary ribs                       13,17,14

             40- SKELETAL/STERNEBRAE: Hypoplastic sternebrae             24,25,26,28

             41- SKELETAL/VERTEBRAE: Hypoplastic vertebral centra        35,36,37,38
  ---------- ----------------------------------------------------------- -------------

K-4

**APPENDIX K -- STATISTICIAN'S REPORT (CONT'D)**

RESULTS:

BODY WEIGHT ANALYSIS

There was no statistically significant difference in the mean fetal
litter weights among the dose groups. Table II shows the mean fetal
weight and the least squares mean fetal weight. The weight difference
between the male and female pups was not consistent across the dose
groups; therefore only the mean pup weight respective of sex is
presented.

Table II

Mean fetal weight, the least squares mean fetal weight

+-----------------+---------+---------+--------------+-----------------+
| Exposure Group  | n       | n       | observed     | Least squares   |
|                 | litters | fetuses | fetus mean   | fetus mean (gm) |
| (mg/m^3^)       |         |         | (gm)         |                 |
+-----------------+---------+---------+--------------+-----------------+
| 0               | 25      | 353     | 5.32         | 5.33            |
+-----------------+---------+---------+--------------+-----------------+
| 2,000           | 23      | 329     | 5.31         | 5.34            |
+-----------------+---------+---------+--------------+-----------------+
| 10,000          | 24      | 325     | 5.30         | 5.29            |
+-----------------+---------+---------+--------------+-----------------+
| 20,000          | 24      | 342     | 5.27         | 5.25            |
+-----------------+---------+---------+--------------+-----------------+

ANOMALY ANALYSES

The analyses of the incidence of combined external variations and
malformations (all fetuses) and of combined external malformations (all
fetuses) indicated a statistically significant increased incidence in
the control group relative to the dosed groups. This finding is
considered a statistical anomaly.

None of the malformation or variation analyses indicated statistically
significant differences among the dose groups. Incidence tables are
provided in the appendix.

CONCLUSION:

Based on these findings, administration of the test substance at the
exposures tested is not associated with a change in mean litter fetal
body weight or any change in head, external, abdomen/thorax and skeletal
malformations/variations.

Mark J. Nicolich, Ph.D. Date

Statistician

ExxonMobil Biomedical Sciences, Inc

1545 Route 22 East

PO Box 971

Annandale, NJ 08801-0971

George Bukhbinder, Ph.D. Date

Consultant

K-5

**APPENDIX K -- STATISTICIAN'S REPORT (CONT'D)**

References:

Chen, Gaylor, and Laborde, "Dose-response modeling of growth for
developmental toxicity", Environmetrics, vol 7, pg 135-144, 1996.

Little, Milliken, Stroup, and Wolfinger, "SAS System for Mixed Models",
SAS Institute, Cary, NC, 1997, section 5.6.2, pg 203.

Ryan, L., "The use of generalized estimating equations for risk
assessment in developmental toxicity", Risk Analysis, 12(3), pg 439-447,
1992.

SAS/STAT, V8.02, copyright © 1999-2001, SAS Institute, Inc., Cary, NC.

K-6

**APPENDIX K -- STATISTICIAN'S REPORT (CONT'D)**

APPENDIX

Anomaly Counts

Study \# 171634

Head Variations and Malformations - combined

All Fetuses

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 178 2 2

2000 MG/M3 23 164 0 0

10000 MG/M3 24 162 1 1

20000 MG/M3 24 172 1 1

Head Variations and Malformations - combined

Alive Fetuses

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 177 1 1

2000 MG/M3 23 164 0 0

10000 MG/M3 24 162 1 1

20000 MG/M3 24 171 1 1

Head Variations and Malformations - combined

Dead Fetuses

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 1 1 1 1

20000 MG/M3 1 1 0 0

Head Variations - combined

All Fetuses

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 178 1 1

2000 MG/M3 23 164 0 0

10000 MG/M3 24 162 0 0

20000 MG/M3 24 172 0 0

K-7

**APPENDIX K -- STATISTICIAN'S REPORT (CONT'D)**

Head Variations - combined

Alive Fetuses

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 177 0 0

2000 MG/M3 23 164 0 0

10000 MG/M3 24 162 0 0

20000 MG/M3 24 171 0 0

Head Variations - combined

Dead Fetuses

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 1 1 1 1

20000 MG/M3 1 1 0 0

Head Malformations - combined

All Fetuses

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 178 2 2

2000 MG/M3 23 164 0 0

10000 MG/M3 24 162 1 1

20000 MG/M3 24 172 1 1

Head Malformations - combined

Alive Fetuses

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 177 1 1

2000 MG/M3 23 164 0 0

10000 MG/M3 24 162 1 1

20000 MG/M3 24 171 1 1

K-8

**APPENDIX K -- STATISTICIAN'S REPORT (CONT'D)**

Head Malformations - combined

Dead Fetuses

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 1 1 1 1

20000 MG/M3 1 1 0 0

head - individual

HEAD: Anolphthalmia; Bilateral

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 178 1 1

2000 MG/M3 23 164 0 0

10000 MG/M3 24 162 0 0

20000 MG/M3 24 172 0 0

head - individual

HEAD: Dilated lateral ventricles; Bilateral

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 178 1 1

2000 MG/M3 23 164 0 0

10000 MG/M3 24 162 0 0

20000 MG/M3 24 172 0 0

head - individual

HEAD: Open eye; Right

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 178 0 0

2000 MG/M3 23 164 0 0

10000 MG/M3 24 162 0 0

20000 MG/M3 24 172 1 1

K-9

**APPENDIX K -- STATISTICIAN'S REPORT (CONT'D)**

head - individual

HEAD: Retina fold

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 178 1 1

2000 MG/M3 23 164 0 0

10000 MG/M3 24 162 1 1

20000 MG/M3 24 172 0 0

External Variations and Malformations - combined

All Fetuses

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 354 4 4

2000 MG/M3 23 329 1 1

10000 MG/M3 24 325 0 0

20000 MG/M3 24 343 0 0

External Variations and Malformations - combined

Alive Fetuses

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 353 3 3

2000 MG/M3 23 329 1 1

10000 MG/M3 24 325 0 0

20000 MG/M3 24 342 0 0

External Variations and Malformations - combined

Dead Fetuses

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 1 1 1 1

20000 MG/M3 1 1 0 0

K-10

**APPENDIX K -- STATISTICIAN'S REPORT (CONT'D)**

External Malformations - combined

All Fetuses

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 354 4 4

2000 MG/M3 23 329 1 1

10000 MG/M3 24 325 0 0

20000 MG/M3 24 343 0 0

External Malformations - combined

Alive Fetuses

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 353 3 3

2000 MG/M3 23 329 1 1

10000 MG/M3 24 325 0 0

20000 MG/M3 24 342 0 0

External Malformations - combined

Dead Fetuses

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 1 1 1 1

20000 MG/M3 1 1 0 0

external - individual

EXTERNAL: Acaudate

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 354 1 1

2000 MG/M3 23 329 0 0

10000 MG/M3 24 325 0 0

20000 MG/M3 24 343 0 0

K-11

**APPENDIX K -- STATISTICIAN'S REPORT (CONT'D)**

external - individual

EXTERNAL: Anal atresia

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 354 1 1

2000 MG/M3 23 329 0 0

10000 MG/M3 24 325 0 0

20000 MG/M3 24 343 0 0

external - individual

EXTERNAL: Anasarca

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 354 1 1

2000 MG/M3 23 329 0 0

10000 MG/M3 24 325 0 0

20000 MG/M3 24 343 0 0

external - individual

EXTERNAL: Brachydactyly; all paws

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 354 1 1

2000 MG/M3 23 329 0 0

10000 MG/M3 24 325 0 0

20000 MG/M3 24 343 0 0

external - individual

EXTERNAL: Conjoined twin; Joined at thoracic region;

1 head, 8 limbs, 2 tails, 1 umbilicus

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 354 0 0

2000 MG/M3 23 329 1 1

10000 MG/M3 24 325 0 0

20000 MG/M3 24 343 0 0

K-12

**APPENDIX K -- STATISTICIAN'S REPORT (CONT'D)**

external - individual

EXTERNAL: Domed head

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 354 1 1

2000 MG/M3 23 329 0 0

10000 MG/M3 24 325 0 0

20000 MG/M3 24 343 0 0

external - individual

EXTERNAL: Ectrodactyly; all paws

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 354 1 1

2000 MG/M3 23 329 0 0

10000 MG/M3 24 325 0 0

20000 MG/M3 24 343 0 0

external - individual

EXTERNAL: Kyphosis

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 354 1 1

2000 MG/M3 23 329 0 0

10000 MG/M3 24 325 0 0

20000 MG/M3 24 343 0 0

external - individual

EXTERNAL: Malrotated hindpaw; Left

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 354 2 2

2000 MG/M3 23 329 0 0

10000 MG/M3 24 325 0 0

20000 MG/M3 24 343 0 0

K-13

**APPENDIX K -- STATISTICIAN'S REPORT (CONT'D)**

external - individual

EXTERNAL: Small eye bulge; Bilateral

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 354 1 1

2000 MG/M3 23 329 0 0

10000 MG/M3 24 325 0 0

20000 MG/M3 24 343 0 0

Visceral Variations and Malformations - combined

All Fetuses

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 178 6 7

2000 MG/M3 23 165 5 6

10000 MG/M3 24 162 2 3

20000 MG/M3 24 172 1 1

Visceral Variations and Malformations - combined

Alive Fetuses

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 177 5 6

2000 MG/M3 23 165 5 6

10000 MG/M3 24 162 2 3

20000 MG/M3 24 171 1 1

Visceral Variations and Malformations - combined

Dead Fetuses

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 1 1 1 1

20000 MG/M3 1 1 0 0

K-14

**APPENDIX K -- STATISTICIAN'S REPORT (CONT'D)**

Visceral Variations - combined

All Fetuses

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 178 3 4

2000 MG/M3 23 165 2 2

10000 MG/M3 24 162 2 3

20000 MG/M3 24 172 0 0

Visceral Variations - combined

Alive Fetuses

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 177 3 4

2000 MG/M3 23 165 2 2

10000 MG/M3 24 162 2 3

20000 MG/M3 24 171 0 0

Visceral Variations - combined

Dead Fetuses

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 1 1 0 0

20000 MG/M3 1 1 0 0

Visceral Malformations - combined

All Fetuses

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 178 4 4

2000 MG/M3 23 165 4 4

10000 MG/M3 24 162 0 0

20000 MG/M3 24 172 1 1

K-15

**APPENDIX K -- STATISTICIAN'S REPORT (CONT'D)**

Visceral Malformations - combined

Alive Fetuses

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 177 3 3

2000 MG/M3 23 165 4 4

10000 MG/M3 24 162 0 0

20000 MG/M3 24 171 1 1

Visceral Malformations - combined

Dead Fetuses

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 1 1 1 1

20000 MG/M3 1 1 0 0

visceral - individual

ABDOMEN/THORAX: Cecum not evident;

bifurcation appears in area where cecum would normally reside

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 178 0 0

2000 MG/M3 23 165 1 1

10000 MG/M3 24 162 0 0

20000 MG/M3 24 172 0 0

visceral - individual

ABDOMEN/THORAX: Double aorta

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 178 0 0

2000 MG/M3 23 165 1 1

10000 MG/M3 24 162 0 0

20000 MG/M3 24 172 0 0

K-16

**APPENDIX K -- STATISTICIAN'S REPORT (CONT'D)**

visceral - individual

ABDOMEN/THORAX: Duplicate tongue

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 178 0 0

2000 MG/M3 23 165 1 1

10000 MG/M3 24 162 0 0

20000 MG/M3 24 172 0 0

visceral - individual

ABDOMEN/THORAX: Elongated innominate artery

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 178 0 0

2000 MG/M3 23 165 1 1

10000 MG/M3 24 162 0 0

20000 MG/M3 24 172 0 0

visceral - individual

ABDOMEN/THORAX: Enlarged atrial chamber; Right

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 178 0 0

2000 MG/M3 23 165 1 1

10000 MG/M3 24 162 0 0

20000 MG/M3 24 172 0 0

visceral - individual

ABDOMEN/THORAX: Hydronephrosis

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 178 2 2

2000 MG/M3 23 165 1 1

10000 MG/M3 24 162 0 0

20000 MG/M3 24 172 0 0

K-17

**APPENDIX K -- STATISTICIAN'S REPORT (CONT'D)**

visceral - individual

ABDOMEN/THORAX: Hydroureter

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 178 2 2

2000 MG/M3 23 165 1 1

10000 MG/M3 24 162 0 0

20000 MG/M3 24 172 0 0

visceral - individual

ABDOMEN/THORAX: Innominate artery absent

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 178 1 1

2000 MG/M3 23 165 0 0

10000 MG/M3 24 162 0 0

20000 MG/M3 24 172 0 0

visceral - individual

ABDOMEN/THORAX: Malpositioned carotid

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 178 1 1

2000 MG/M3 23 165 0 0

10000 MG/M3 24 162 0 0

20000 MG/M3 24 172 0 0

visceral - individual

ABDOMEN/THORAX: Malpositioned carotid and subclavian branches; Bilateral

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 178 0 0

2000 MG/M3 23 165 1 1

10000 MG/M3 24 162 0 0

20000 MG/M3 24 172 0 0

K-18

**APPENDIX K -- STATISTICIAN'S REPORT (CONT'D)**

visceral - individual

ABDOMEN/THORAX: Malpositioned kidneys

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 178 1 1

2000 MG/M3 23 165 0 0

10000 MG/M3 24 162 0 0

20000 MG/M3 24 172 0 0

visceral - individual

ABDOMEN/THORAX: Malpositioned ovaries

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 178 1 1

2000 MG/M3 23 165 0 0

10000 MG/M3 24 162 0 0

20000 MG/M3 24 172 0 0

visceral - individual

ABDOMEN/THORAX: Malpositioned pulmonary artery branch

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 178 0 0

2000 MG/M3 23 165 1 1

10000 MG/M3 24 162 0 0

20000 MG/M3 24 172 0 0

visceral - individual

ABDOMEN/THORAX: Malpositioned subclavian branch; Right

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 178 1 1

2000 MG/M3 23 165 0 0

10000 MG/M3 24 162 0 0

20000 MG/M3 24 172 0 0

K-19

**APPENDIX K -- STATISTICIAN'S REPORT (CONT'D)**

visceral - individual

ABDOMEN/THORAX: Malpositioned uterus

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 178 1 1

2000 MG/M3 23 165 0 0

10000 MG/M3 24 162 0 0

20000 MG/M3 24 172 0 0

visceral - individual

ABDOMEN/THORAX: Misshapen spleen

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 178 0 0

2000 MG/M3 23 165 1 1

10000 MG/M3 24 162 0 0

20000 MG/M3 24 172 0 0

visceral - individual

ABDOMEN/THORAX: No cervical spinal column

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 178 1 1

2000 MG/M3 23 165 0 0

10000 MG/M3 24 162 0 0

20000 MG/M3 24 172 0 0

visceral - individual

ABDOMEN/THORAX: Spleen small

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 178 0 0

2000 MG/M3 23 165 1 1

10000 MG/M3 24 162 0 0

20000 MG/M3 24 172 0 0

K-20

**APPENDIX K -- STATISTICIAN'S REPORT (CONT'D)**

visceral - individual

ABDOMEN/THORAX: Supernumerary lung lobe; Left

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 178 0 0

2000 MG/M3 23 165 1 1

10000 MG/M3 24 162 0 0

20000 MG/M3 24 172 0 0

visceral - individual

ABDOMEN/THORAX: Umbilical artery aneurysm

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 178 0 0

2000 MG/M3 23 165 0 0

10000 MG/M3 24 162 0 0

20000 MG/M3 24 172 1 1

visceral - individual

ABDOMEN/THORAX: Umbilical artery arises from left side of urinary
bladder

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 178 3 4

2000 MG/M3 23 165 1 1

10000 MG/M3 24 162 2 3

20000 MG/M3 24 172 0 0

visceral - individual

ABDOMEN/THORAX: Ventricle small; Left

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 178 0 0

2000 MG/M3 23 165 1 1

10000 MG/M3 24 162 0 0

20000 MG/M3 24 172 0 0

K-21

**APPENDIX K -- STATISTICIAN'S REPORT (CONT'D)**

visceral - combined

ABDOMEN/THORAX: Abnormal spleen

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 178 0 0

2000 MG/M3 23 165 2 2

10000 MG/M3 24 162 0 0

20000 MG/M3 24 172 0 0

visceral - combined

ABDOMEN/THORAX: Abnormal thoracic/cervical blood vessels

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 178 1 1

2000 MG/M3 23 165 2 2

10000 MG/M3 24 162 0 0

20000 MG/M3 24 172 0 0

visceral - combined

ABDOMEN/THORAX: Malpositioned urogenital organs

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 25 178 1 1

2000 MG/M3 23 165 0 0

10000 MG/M3 24 162 0 0

20000 MG/M3 24 172 0 0

Skeletal Variations and Malformations - combined

All Fetuses

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 17 39

2000 MG/M3 23 165 16 29

10000 MG/M3 24 163 18 42

20000 MG/M3 24 171 18 42

K-22

**APPENDIX K -- STATISTICIAN'S REPORT (CONT'D)**

Skeletal Variations and Malformations - combined

Alive Fetuses

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 17 39

2000 MG/M3 23 165 16 29

10000 MG/M3 24 163 18 42

20000 MG/M3 24 171 18 42

Skeletal Variations - combined

All Fetuses

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 17 39

2000 MG/M3 23 165 16 29

10000 MG/M3 24 163 18 42

20000 MG/M3 24 171 18 42

Skeletal Variations - combined

Alive Fetuses

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 17 39

2000 MG/M3 23 165 16 29

10000 MG/M3 24 163 18 42

20000 MG/M3 24 171 18 42

Skeletal Malformations - combined

All Fetuses

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 1 1

2000 MG/M3 23 165 1 1

10000 MG/M3 24 163 1 1

20000 MG/M3 24 171 0 0

K-23

**APPENDIX K -- STATISTICIAN'S REPORT (CONT'D)**

Skeletal Malformations - combined

Alive Fetuses

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 1 1

2000 MG/M3 23 165 1 1

10000 MG/M3 24 163 1 1

20000 MG/M3 24 171 0 0

skeletal - individual

SKELETAL/FORELIMB (All bones ): Duplication or extra bones

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 0 0

2000 MG/M3 23 165 1 1

10000 MG/M3 24 163 0 0

20000 MG/M3 24 171 0 0

skeletal - individual

SKELETAL/FOREPAW (All bones): Duplication or extra bones

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 0 0

2000 MG/M3 23 165 1 1

10000 MG/M3 24 163 0 0

20000 MG/M3 24 171 0 0

skeletal - individual

SKELETAL/FOREPAW (Metacarpal 1 anlage): Misshapen; Left

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 0 0

2000 MG/M3 23 165 0 0

10000 MG/M3 24 163 1 1

20000 MG/M3 24 171 0 0

K-24

**APPENDIX K -- STATISTICIAN'S REPORT (CONT'D)**

skeletal - individual

SKELETAL/FOREPAW (Proximal phalanges 2-4): Unossified; Bilateral

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 1 1

2000 MG/M3 23 165 0 0

10000 MG/M3 24 163 0 0

20000 MG/M3 24 171 0 0

skeletal - individual

SKELETAL/HINDLIMB (All bones): Duplication or extra bones; Bilateral

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 0 0

2000 MG/M3 23 165 1 1

10000 MG/M3 24 163 0 0

20000 MG/M3 24 171 0 0

skeletal - individual

SKELETAL/HINDPAW (All bones): Duplication or extra bones; Bilateral

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 0 0

2000 MG/M3 23 165 1 1

10000 MG/M3 24 163 0 0

20000 MG/M3 24 171 0 0

skeletal - individual

SKELETAL/HINDPAW (Calcaneus): Advanced; Bilateral

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 1 1

2000 MG/M3 23 165 0 0

10000 MG/M3 24 163 0 0

20000 MG/M3 24 171 0 0

K-25

**APPENDIX K -- STATISTICIAN'S REPORT (CONT'D)**

skeletal - individual

SKELETAL/PECTORAL GIRDLE (All bones):

Duplication or extra bones; Bilateral

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 0 0

2000 MG/M3 23 165 1 1

10000 MG/M3 24 163 0 0

20000 MG/M3 24 171 0 0

skeletal - individual

SKELETAL/PELVIC GIRDLE (All bones):

Duplication or extra bones; Bilateral

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 0 0

2000 MG/M3 23 165 1 1

10000 MG/M3 24 163 0 0

20000 MG/M3 24 171 0 0

skeletal - individual

SKELETAL/RIBS (All bones): Duplication or extra bones

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 0 0

2000 MG/M3 23 165 1 1

10000 MG/M3 24 163 0 0

20000 MG/M3 24 171 0 0

skeletal - individual

SKELETAL/RIBS (C7 and T1 Anlage):

Fused; Anlage on C7 and T1 rib fused before it meets sternebrae

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 1 1

2000 MG/M3 23 165 0 0

10000 MG/M3 24 163 0 0

20000 MG/M3 24 171 0 0

K-26

**APPENDIX K -- STATISTICIAN'S REPORT (CONT'D)**

skeletal - individual

SKELETAL/RIBS (C7, C7 Anlage): Cervical rib; Bilateral

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 1 1

2000 MG/M3 23 165 0 0

10000 MG/M3 24 163 0 0

20000 MG/M3 24 171 0 0

skeletal - individual

SKELETAL/RIBS (L1): Well-formed; Left

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 0 0

2000 MG/M3 23 165 0 0

10000 MG/M3 24 163 0 0

20000 MG/M3 24 171 1 1

skeletal - individual

SKELETAL/RIBS (Right twin T8 left, Left twin T8 right): Fused; Left

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 0 0

2000 MG/M3 23 165 1 1

10000 MG/M3 24 163 0 0

20000 MG/M3 24 171 0 0

skeletal - individual

SKELETAL/RIBS (T13): Short last rib; Right

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 2 2

2000 MG/M3 23 165 0 0

10000 MG/M3 24 163 1 1

20000 MG/M3 24 171 0 0

K-27

**APPENDIX K -- STATISTICIAN'S REPORT (CONT'D)**

skeletal - individual

SKELETAL/RIBS: Rudimentary supernumary ribs

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 9 17

2000 MG/M3 23 165 10 15

10000 MG/M3 24 163 13 23

20000 MG/M3 24 171 13 24

skeletal - individual

SKELETAL/SKULL (Interparietal): Misshapen

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 0 0

2000 MG/M3 23 165 1 1

10000 MG/M3 24 163 0 0

20000 MG/M3 24 171 0 0

skeletal - individual

SKELETAL/SKULL (Squamosal Process): Hypoplastic; Left

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 0 0

2000 MG/M3 23 165 1 1

10000 MG/M3 24 163 0 0

20000 MG/M3 24 171 0 0

skeletal - individual

SKELETAL/SKULL (Supraoccipital,Interparietal,Parietals,Frontals,Nasals):

Duplication or extra bones

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 0 0

2000 MG/M3 23 165 1 1

10000 MG/M3 24 163 0 0

20000 MG/M3 24 171 0 0

K-28

**APPENDIX K -- STATISTICIAN'S REPORT (CONT'D)**

skeletal - individual

SKELETAL/SKULL (Tympanics): Hypoplastic

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 0 0

2000 MG/M3 23 165 0 0

10000 MG/M3 24 163 1 1

20000 MG/M3 24 171 0 0

skeletal - individual

SKELETAL/STERNEBRAE (All bones): Duplication or extra bones

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 0 0

2000 MG/M3 23 165 1 1

10000 MG/M3 24 163 0 0

20000 MG/M3 24 171 0 0

skeletal - individual

SKELETAL/STERNEBRAE (VI): Advanced

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 1 1

2000 MG/M3 23 165 2 2

10000 MG/M3 24 163 1 2

20000 MG/M3 24 171 0 0

skeletal - individual

SKELETAL/STERNEBRAE: Asymmetric sternebrae

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 0 0

2000 MG/M3 23 165 2 2

10000 MG/M3 24 163 1 1

20000 MG/M3 24 171 1 2

K-29

**APPENDIX K -- STATISTICIAN'S REPORT (CONT'D)**

skeletal - individual

SKELETAL/STERNEBRAE: Bifid sternebrae

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 0 0

2000 MG/M3 23 165 1 1

10000 MG/M3 24 163 0 0

20000 MG/M3 24 171 1 1

skeletal - individual

SKELETAL/STERNEBRAE: Dumbbell-shaped sternebrae

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 0 0

2000 MG/M3 23 165 0 0

10000 MG/M3 24 163 0 0

20000 MG/M3 24 171 1 3

skeletal - individual

SKELETAL/STERNEBRAE: Hypoplastic sternebrae

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 0 0

2000 MG/M3 23 165 0 0

10000 MG/M3 24 163 1 1

20000 MG/M3 24 171 1 1

skeletal - individual

SKELETAL/STERNEBRAE: Misshapen sternebrae

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 3 4

2000 MG/M3 23 165 3 6

10000 MG/M3 24 163 2 2

20000 MG/M3 24 171 5 5

K-30

**APPENDIX K -- STATISTICIAN'S REPORT (CONT'D)**

skeletal - individual

SKELETAL/STERNEBRAE: Unossified sternebrae

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 3 3

2000 MG/M3 23 165 0 0

10000 MG/M3 24 163 3 5

20000 MG/M3 24 171 6 10

skeletal - individual

SKELETAL/VERTEBRAE (All bones): Duplication or extra bones

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 0 0

2000 MG/M3 23 165 1 1

10000 MG/M3 24 163 0 0

20000 MG/M3 24 171 0 0

skeletal - individual

SKELETAL/VERTEBRAE (CE3 Anlage): Bifid centra

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 0 0

2000 MG/M3 23 165 0 0

10000 MG/M3 24 163 0 0

20000 MG/M3 24 171 1 1

skeletal - individual

SKELETAL/VERTEBRAE (L): One less presacral vertebrae

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 0 0

2000 MG/M3 23 165 0 0

10000 MG/M3 24 163 1 1

20000 MG/M3 24 171 0 0

K-31

**APPENDIX K -- STATISTICIAN'S REPORT (CONT'D)**

skeletal - individual

SKELETAL/VERTEBRAE (L1): Misshapen centra

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 0 0

2000 MG/M3 23 165 0 0

10000 MG/M3 24 163 1 1

20000 MG/M3 24 171 0 0

skeletal - individual

SKELETAL/VERTEBRAE (Left twin CE 1-7): Fused

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 0 0

2000 MG/M3 23 165 1 1

10000 MG/M3 24 163 0 0

20000 MG/M3 24 171 0 0

skeletal - individual

SKELETAL/VERTEBRAE (Left twin T2): Unossified centra

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 0 0

2000 MG/M3 23 165 1 1

10000 MG/M3 24 163 0 0

20000 MG/M3 24 171 0 0

skeletal - individual

SKELETAL/VERTEBRAE (Left twin T3): Hemicentra

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 0 0

2000 MG/M3 23 165 1 1

10000 MG/M3 24 163 0 0

20000 MG/M3 24 171 0 0

K-32

**APPENDIX K -- STATISTICIAN'S REPORT (CONT'D)**

skeletal - individual

SKELETAL/VERTEBRAE: Bifid vertebral centra

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 6 7

2000 MG/M3 23 165 6 6

10000 MG/M3 24 163 3 6

20000 MG/M3 24 171 5 5

skeletal - individual

SKELETAL/VERTEBRAE: Dumbbell-shaped vertebral centra

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 3 3

2000 MG/M3 23 165 1 1

10000 MG/M3 24 163 2 3

20000 MG/M3 24 171 2 2

skeletal - individual

SKELETAL/VERTEBRAE: Dumbbell-shaped vertebral centra anlage

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 8 12

2000 MG/M3 23 165 4 4

10000 MG/M3 24 163 5 9

20000 MG/M3 24 171 3 3

skeletal - combined

SKELETAL/RIBS: Supernumerary ribs

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 9 18

2000 MG/M3 23 165 10 15

10000 MG/M3 24 163 13 23

20000 MG/M3 24 171 13 24

K-33

**APPENDIX K -- STATISTICIAN'S REPORT (CONT'D)**

skeletal - combined

SKELETAL/STERNEBRAE: Hypoplastic sternebrae

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 3 3

2000 MG/M3 23 165 1 1

10000 MG/M3 24 163 4 6

20000 MG/M3 24 171 7 12

skeletal - combined

SKELETAL/VERTEBRAE: Hypoplastic vertebral centra

dams fetuses dams fetuses

DOSE examined examined affected affected

0 MG/M3 24 176 7 10

2000 MG/M3 23 165 7 8

10000 MG/M3 24 163 4 8

20000 MG/M3 24 171 6 6

K-34

**APPENDIX L - HISTORICAL CONTROL DATA FOR ANNANDALE, NJ FACILITY**

**TESTING FACILITY -- ANNANDALE, NJ**

SUPPLIER: Charles River Laboratories, Inc.

FEED: PMI Certified Rodent Chow (5002 Meal)

+-----+---------+---------+----------+---------+--------+-------------+
| ST  | STUDY   | S       | SPECIE   | NUMBER  | \%     | DOSING      |
| UDY | DATES   | UPPLIER | S/STRAIN | OF      | PR     | RO          |
| NUM |         | LOCATI  |          | L       | EGNANT | UTE/CARRIER |
| BER |         | ON/AREA |          | ITTERS/ |        |             |
|     |         |         |          | FETUSES |        |             |
+-----+---------+---------+----------+---------+--------+-------------+
| 9A  | May 9,  | R       | Cr       | 25/398  | 100    | Oral/Corn   |
|     | 2000 -- | aleigh, | l:CD^®^( |         |        | Oil         |
|     |         | NC/R04  | SD)IGSBR |         |        |             |
|     | June 2, |         | VAF/Plus |         |        |             |
|     | 2000    |         |          |         |        |             |
+-----+---------+---------+----------+---------+--------+-------------+
| 9B  | May 9,  | R       | Cr       | 25/401  | 100    | Oral/Corn   |
|     | 2000 -- | aleigh, | l:CD^®^( |         |        | Oil         |
|     |         | NC/R04  | SD)IGSBR |         |        |             |
|     | June 2, |         | VAF/Plus |         |        |             |
|     | 2000    |         |          |         |        |             |
+-----+---------+---------+----------+---------+--------+-------------+
| 10  | May 19, | R       | Cr       | 24/359  | 96     | Inh         |
|     | 2001 -- | aleigh, | l:CD^®^( |         |        | alation/Air |
|     |         | NC/R04  | SD)IGSBR |         |        |             |
|     | June    |         | VAF/Plus |         |        |             |
|     | 15,     |         |          |         |        |             |
|     | 2001    |         |          |         |        |             |
+-----+---------+---------+----------+---------+--------+-------------+
| 11  | August  | R       | Cr       | 24/358  | 96     | Inh         |
|     | 19,     | aleigh, | l:CD^®^( |         |        | alation/Air |
|     | 2001 -- | NC/R04  | SD)IGSBR |         |        |             |
|     |         |         | VAF/Plus |         |        |             |
|     | Se      |         |          |         |        |             |
|     | ptember |         |          |         |        |             |
|     | 18,     |         |          |         |        |             |
|     | 2001    |         |          |         |        |             |
+-----+---------+---------+----------+---------+--------+-------------+
| 12  | N       | R       | Cr       | 25/389  | 100    | Inh         |
|     | ovember | aleigh, | l:CD^®^( |         |        | alation/Air |
|     | 18,     | NC/R04  | SD)IGSBR |         |        |             |
|     | 2001    |         | VAF/Plus |         |        |             |
|     | -D      |         |          |         |        |             |
|     | ecember |         |          |         |        |             |
|     | 20,     |         |          |         |        |             |
|     | 2001    |         |          |         |        |             |
+-----+---------+---------+----------+---------+--------+-------------+
| 13  | F       | R       | Cr       | 25/374  | 100    | Inh         |
|     | ebruary | aleigh, | l:CD^®^( |         |        | alation/Air |
|     | 3, 2002 | NC/R04  | SD)IGSBR |         |        |             |
|     | --      |         | VAF/Plus |         |        |             |
|     |         |         |          |         |        |             |
|     | March   |         |          |         |        |             |
|     | 8, 2001 |         |          |         |        |             |
+-----+---------+---------+----------+---------+--------+-------------+

L-1

**APPENDIX L - HISTORICAL CONTROL DATA FOR ANNANDALE, NJ FACILITY
(CONT'D)**

**(UTERINE IMPLANTATION DATA)**

<table>
<colgroup>
<col style="width: 6%" />
<col style="width: 7%" />
<col style="width: 3%" />
<col style="width: 4%" />
<col style="width: 6%" />
<col style="width: 10%" />
<col style="width: 8%" />
<col style="width: 9%" />
<col style="width: 4%" />
<col style="width: 10%" />
<col style="width: 14%" />
<col style="width: 12%" />
</colgroup>
<tbody>
<tr class="odd">
<td></td>
<td><p>NUMBER</p>
<p>OF</p>
<p>LITTERS</p></td>
<td>LIVE</td>
<td>MALE</td>
<td>FEMALE</td>
<td>RESORPTIONS</td>
<td>IMPLANTS</td>
<td>CORPORA LUTEA</td>
<td>DEAD</td>
<td>FETUS/ IMPLANTS</td>
<td>RESORPTIONS/ IMPLANTS</td>
<td>F/I TRANSFORMED</td>
</tr>
<tr class="even">
<td>HIGH</td>
<td></td>
<td>16.04</td>
<td>7.92</td>
<td>8.36</td>
<td>0.72</td>
<td>16.48</td>
<td>17.16</td>
<td>0</td>
<td>0.98</td>
<td>0.05</td>
<td>80.376320</td>
</tr>
<tr class="odd">
<td>LOW</td>
<td></td>
<td>14.92</td>
<td>7.17</td>
<td>7.42</td>
<td>0.32</td>
<td>15.50</td>
<td>15.96</td>
<td>0</td>
<td>0.95</td>
<td>0.02</td>
<td>77.306160</td>
</tr>
<tr class="even">
<td>STUDY #</td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr class="odd">
<td>13</td>
<td>25</td>
<td>14.96</td>
<td>7.36</td>
<td>7.60</td>
<td>0.72</td>
<td>15.68</td>
<td>15.96</td>
<td>0</td>
<td>0.95</td>
<td>0.05</td>
<td>77.306160</td>
</tr>
<tr class="even">
<td>STD</td>
<td></td>
<td>3.12</td>
<td>2.45</td>
<td>2.42</td>
<td>0.84</td>
<td>3.09</td>
<td>3.18</td>
<td>0</td>
<td>0.07</td>
<td>0.07</td>
<td>6.507916</td>
</tr>
<tr class="odd">
<td>(N)</td>
<td></td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
</tr>
<tr class="even">
<td>12</td>
<td>25</td>
<td>15.56</td>
<td>7.92</td>
<td>7.64</td>
<td>0.32</td>
<td>15.88</td>
<td>16.40</td>
<td>0</td>
<td>0.98</td>
<td>0.02</td>
<td>80.376320</td>
</tr>
<tr class="odd">
<td>STD</td>
<td></td>
<td>2.92</td>
<td>2.64</td>
<td>2.38</td>
<td>0.56</td>
<td>2.88</td>
<td>2.99</td>
<td>0</td>
<td>0.04</td>
<td>0.03</td>
<td>3.947106</td>
</tr>
<tr class="even">
<td>(N)</td>
<td></td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
</tr>
<tr class="odd">
<td>11</td>
<td>24</td>
<td>14.92</td>
<td>7.17</td>
<td>7.75</td>
<td>0.63</td>
<td>15.54</td>
<td>16.04</td>
<td>0</td>
<td>0.96</td>
<td>0.04</td>
<td>78.114083</td>
</tr>
<tr class="even">
<td>STD</td>
<td></td>
<td>2.19</td>
<td>2.57</td>
<td>2.27</td>
<td>0.77</td>
<td>1.82</td>
<td>1.94</td>
<td>0</td>
<td>0.05</td>
<td>0.05</td>
<td>5.545914</td>
</tr>
<tr class="odd">
<td>(N)</td>
<td></td>
<td>24</td>
<td>24</td>
<td>24</td>
<td>24</td>
<td>24</td>
<td>24</td>
<td>24</td>
<td>24</td>
<td>24</td>
<td>24</td>
</tr>
<tr class="even">
<td>10</td>
<td>24</td>
<td>14.96</td>
<td>7.54</td>
<td>7.42</td>
<td>0.58</td>
<td>15.50</td>
<td>16.42</td>
<td>0</td>
<td>0.97</td>
<td>0.04</td>
<td>78.883958</td>
</tr>
<tr class="odd">
<td>STD</td>
<td></td>
<td>3.07</td>
<td>2.90</td>
<td>2.55</td>
<td>0.83</td>
<td>3.18</td>
<td>3.41</td>
<td>0</td>
<td>0.05</td>
<td>0.05</td>
<td>5.408551</td>
</tr>
<tr class="even">
<td>(N)</td>
<td></td>
<td>24</td>
<td>24</td>
<td>24</td>
<td>24</td>
<td>24</td>
<td>24</td>
<td>24</td>
<td>24</td>
<td>24</td>
<td>24</td>
</tr>
<tr class="odd">
<td>9(B)</td>
<td>25</td>
<td>16.04</td>
<td>7.84</td>
<td>8.20</td>
<td>0.44</td>
<td>16.48</td>
<td>17.16</td>
<td>0</td>
<td>0.97</td>
<td>0.03</td>
<td>79.840760</td>
</tr>
<tr class="even">
<td>STD</td>
<td></td>
<td>2.24</td>
<td>1.57</td>
<td>1.91</td>
<td>0.77</td>
<td>2.02</td>
<td>1.93</td>
<td>0</td>
<td>0.05</td>
<td>0.05</td>
<td>5.232909</td>
</tr>
<tr class="odd">
<td>(N)</td>
<td></td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
</tr>
<tr class="even">
<td>9(A)</td>
<td>25</td>
<td>15.92</td>
<td>7.56</td>
<td>8.36</td>
<td>0.52</td>
<td>16.44</td>
<td>16.88</td>
<td>0</td>
<td>0.97</td>
<td>0.03</td>
<td>79.294360</td>
</tr>
<tr class="odd">
<td>STD</td>
<td></td>
<td>1.53</td>
<td>1.69</td>
<td>1.60</td>
<td>0.71</td>
<td>1.42</td>
<td>1.48</td>
<td>0</td>
<td>0.04</td>
<td>0.04</td>
<td>4.836482</td>
</tr>
<tr class="even">
<td>(N)</td>
<td></td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
</tr>
</tbody>
</table>

L-2

**APPENDIX L - HISTORICAL CONTROL DATA FOR ANNANDALE, NJ FACILITY
(CONT'D)**

**(UTERINE IMPLANTATION DATA)**

<table>
<colgroup>
<col style="width: 5%" />
<col style="width: 7%" />
<col style="width: 12%" />
<col style="width: 12%" />
<col style="width: 9%" />
<col style="width: 9%" />
<col style="width: 10%" />
<col style="width: 13%" />
<col style="width: 9%" />
<col style="width: 8%" />
</colgroup>
<tbody>
<tr class="odd">
<td></td>
<td><p>NUMBER</p>
<p>OF</p>
<p>LITTERS</p></td>
<td>R/I TRANSFORMED</td>
<td>D/I TRANSFORMED</td>
<td>DEAD/ IMPLANTS</td>
<td>PRE IMPLANT LOSS</td>
<td>POST IMPLANT LOSS</td>
<td>MALFORMATIONS</td>
<td>VARIATIONS</td>
<td>AFFECTED</td>
</tr>
<tr class="even">
<td>HIGH</td>
<td></td>
<td>12.694280</td>
<td>7.473</td>
<td>0</td>
<td>5.1</td>
<td>5.1</td>
<td>0.25</td>
<td>1.4</td>
<td>1.00</td>
</tr>
<tr class="odd">
<td>LOW</td>
<td></td>
<td>9.624000</td>
<td>7.103</td>
<td>0</td>
<td>1.60</td>
<td>2.0</td>
<td>0.08</td>
<td>0</td>
<td>0.40</td>
</tr>
<tr class="even">
<td>STUDY #</td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr class="odd">
<td>13</td>
<td>25</td>
<td>12.694280</td>
<td>7.473</td>
<td>0</td>
<td>1.6</td>
<td>5.1</td>
<td>0.24</td>
<td>1.40</td>
<td>1.00</td>
</tr>
<tr class="even">
<td>STD</td>
<td></td>
<td>6.507867</td>
<td>1.521</td>
<td>0</td>
<td>2.7</td>
<td>6.7</td>
<td>0.52</td>
<td>1.60</td>
<td>1.00</td>
</tr>
<tr class="odd">
<td>(N)</td>
<td></td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
</tr>
<tr class="even">
<td>12</td>
<td>25</td>
<td>9.624000</td>
<td>7.326</td>
<td>0</td>
<td>3.0</td>
<td>2.0</td>
<td>0.10</td>
<td>1.40</td>
<td>0.40</td>
</tr>
<tr class="odd">
<td>STD</td>
<td></td>
<td>3.947128</td>
<td>0.905</td>
<td>0</td>
<td>3.9</td>
<td>3.4</td>
<td>0.30</td>
<td>1.20</td>
<td>0.60</td>
</tr>
<tr class="even">
<td>(N)</td>
<td></td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
</tr>
<tr class="odd">
<td>11</td>
<td>24</td>
<td>11.886500</td>
<td>7.324</td>
<td>0</td>
<td>3.0</td>
<td>4.2</td>
<td>0.25</td>
<td>1.10</td>
<td>0.90</td>
</tr>
<tr class="even">
<td>STD</td>
<td></td>
<td>5.545880</td>
<td>0.446</td>
<td>0</td>
<td>3.9</td>
<td>5.4</td>
<td>0.53</td>
<td>1.10</td>
<td>1.10</td>
</tr>
<tr class="odd">
<td>(N)</td>
<td></td>
<td>24</td>
<td>24</td>
<td>24</td>
<td>24</td>
<td>24</td>
<td>24</td>
<td>24</td>
<td>24</td>
</tr>
<tr class="even">
<td>10</td>
<td>24</td>
<td>11.402500</td>
<td>7.455</td>
<td>0</td>
<td>5.1</td>
<td>3.3</td>
<td>0.17</td>
<td>0.70</td>
<td>0.80</td>
</tr>
<tr class="odd">
<td>STD</td>
<td></td>
<td>5.349722</td>
<td>1.087</td>
<td>0</td>
<td>12.6</td>
<td>5.4</td>
<td>0.38</td>
<td>0.80</td>
<td>0.80</td>
</tr>
<tr class="even">
<td>(N)</td>
<td></td>
<td>24</td>
<td>24</td>
<td>24</td>
<td>24</td>
<td>24</td>
<td>24</td>
<td>24</td>
<td>24</td>
</tr>
<tr class="odd">
<td>9(B)</td>
<td>25</td>
<td>10.159600</td>
<td>7.117</td>
<td>0</td>
<td>3.9</td>
<td>2.8</td>
<td>0.08</td>
<td>0.00</td>
<td>0.50</td>
</tr>
<tr class="even">
<td>STD</td>
<td></td>
<td>5.232766</td>
<td>0.478</td>
<td>0</td>
<td>7.0</td>
<td>5.0</td>
<td>0.40</td>
<td>0.00</td>
<td>0.80</td>
</tr>
<tr class="odd">
<td>(N)</td>
<td></td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
</tr>
<tr class="even">
<td>9(A)</td>
<td>25</td>
<td>10.706120</td>
<td>7.103</td>
<td>0</td>
<td>2.5</td>
<td>3.1</td>
<td>0.12</td>
<td>0.10</td>
<td>0.60</td>
</tr>
<tr class="odd">
<td>STD</td>
<td></td>
<td>4.836645</td>
<td>0.318</td>
<td>0</td>
<td>4.3</td>
<td>4.3</td>
<td>0.33</td>
<td>0.40</td>
<td>0.70</td>
</tr>
<tr class="even">
<td>(N)</td>
<td></td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
<td>25</td>
</tr>
</tbody>
</table>

L-3

**APPENDIX L - HISTORICAL CONTROL DATA FOR ANNANDALE, NJ FACILITY
(CONT'D)**

**(FETAL BODY WEIGHTS)**

+------------------+-------------------+------------+-----------------+
|                  | NUMBER            | MALE       | FEMALE          |
|                  |                   |            |                 |
|                  | OF                |            |                 |
|                  |                   |            |                 |
|                  | LITTERS           |            |                 |
+------------------+-------------------+------------+-----------------+
| HIGH             |                   | 5.75       | 5.50            |
+------------------+-------------------+------------+-----------------+
| LOW              |                   | 5.41       | 5.16            |
+------------------+-------------------+------------+-----------------+
| STUDY \#         |                   |            |                 |
+------------------+-------------------+------------+-----------------+
| 13               | 25                | 5.49       | 5.17            |
+------------------+-------------------+------------+-----------------+
| STD              |                   | 0.33       | 0.37            |
+------------------+-------------------+------------+-----------------+
| \(N\)            |                   | 184        | 190             |
+------------------+-------------------+------------+-----------------+
| 12               | 25                | 5.59       | 5.36            |
+------------------+-------------------+------------+-----------------+
| STD              |                   | 0.36       | 0.32            |
+------------------+-------------------+------------+-----------------+
| \(N\)            |                   | 198        | 191             |
+------------------+-------------------+------------+-----------------+
| 11               | 24                | 5.52       | 5.25            |
+------------------+-------------------+------------+-----------------+
| STD              |                   | 0.38       | 0.45            |
+------------------+-------------------+------------+-----------------+
| \(N\)            |                   | 172        | 186             |
+------------------+-------------------+------------+-----------------+
| 10               | 24                | 5.75       | 5.50            |
+------------------+-------------------+------------+-----------------+
| STD              |                   | 0.35       | 0.34            |
+------------------+-------------------+------------+-----------------+
| \(N\)            |                   | 181        | 178             |
+------------------+-------------------+------------+-----------------+
| 9(B)             | 25                | 5.41       | 5.16            |
+------------------+-------------------+------------+-----------------+
| STD              |                   | 0.45       | 0.39            |
+------------------+-------------------+------------+-----------------+
| \(N\)            |                   | 196        | 205             |
+------------------+-------------------+------------+-----------------+
| 9(A)             | 25                | 5.61       | 5.31            |
+------------------+-------------------+------------+-----------------+
| STD              |                   | 0.38       | 0.37            |
+------------------+-------------------+------------+-----------------+
| \(N\)            |                   | 189        | 209             |
+------------------+-------------------+------------+-----------------+

L-4

**APPENDIX L - HISTORICAL CONTROL DATA FOR ANNANDALE, NJ FACILITY
(CONT'D)**

**(EXTERNAL DATA)**

  -------------------------- ------- ------- ------- ------- ------- -------
  STUDY \#                   13      12      11      10      9(B)    9(A)

  NUMBER OF LITTER           25      25      24      24      25      25

  NUMBER OF FETUSES          374     389     358     359     401     398

  \% STUNTED - F             0.27    0.26    0.84    0       1.25    0

  \% STUNTED - L             4.00    4.00    8.33    0       16.00   0

                                                                     

  \% EXT. VAR. - F           0       0       0       0       0       0

  \% EXT. VAR. - L           0       0       0       0       0       0

                                                                     

  \% EXT. MAL - F            0.53    0.26    0.56    0.28    0       0.50

  \% EXT. MAL. - L           8.00    4.00    8.33    4.17    0       8.00

                                                                     

  Malrotated hindpaw - F     0.53    0.26    0.28    0.28            0.50

  Malrotated hindpaw - L     8.00    4.00    4.17    4.17            8.00

  Filamentous tail - F                       0.28                    

  Filamentous tail - L                       4.17                    

                                                                     

                                                                     

                                                                     

                                                                     

                                                                     

  NOTE: F - Fetus                                                    

  L - Litter                                                         
  -------------------------- ------- ------- ------- ------- ------- -------

Blank entries for an observation indicate that the observation was not
present in that study

L-5

**APPENDIX L - HISTORICAL CONTROL DATA FOR ANNANDALE, NJ FACILITY
(CONT'D)**

**(INTERNAL DATA)**

  ----------------------------------- ------- ------ ------- ------- ------ ------
  STUDY \#                            13      12     11      10      9(B)   9(A)

  NUMBER OF LITTER                    25      25     24      24      25     25

  NUMBER OF FETUSES                   182     195    181     178     197    201

  \% VIS. VAR. - F                    0.55    0      0       0       0      1.00

  \% VIS. VAR. - L                    4.00    0      0       0       0      4.00

                                                                            

  \% VIS. MAL. - F                    2.19    0.51   2.21    1.69    1.02   0.50

  \% VIS. MAL. - L                    12.00   4.0    16.67   12.50   4.00   4.00

                                                                            

  Olfactory bulb: Misshapen - F               0.51                          

  Olfactory bulb: Misshapen - L               4.00                          

  Microphthalmia - F                                                 0.51   

  Microphthalmia - L                                                 4.00   

  Retinal fold - F                    1.64                   1.12           

  Retinal fold - L                    8.00                   8.33           

                                                                            

  NOTE: F - Fetus                                                           

  L - Litter                                                                

                                                                            
  ----------------------------------- ------- ------ ------- ------- ------ ------

Blank entries for an observation indicate that the observation was not
present in that study

L-6

**APPENDIX L - HISTORICAL CONTROL DATA FOR ANNANDALE, NJ FACILITY
(CONT'D)**

**(INTERNAL DATA)**

  -------------------------------------- ------ ----- ------- ------ ------ ------
  STUDY \#                               13     12    11      10     9(B)   9(A)

  NUMBER OF LITTER                       25     25    24      24     25     25

  NUMBER OF FETUSES                      182    195   181     178    197    201

  Hydronephrosis - F                                  1.66                  

  Hydronephrosis - L                                  12.50                 

  Ureter(s): Convoluted - F                                                 1.00

  Ureter(s): Convoluted - L                                                 4.00

  Hydroureter - F                                     0.55    0.56   0.51   0.50

  Hydroureter - L                                     4.17    4.17   4.00   4.00

  Umbilical artery: Left of urinary      0.55                               
  bladder - F                                                               

  Umbilical artery: Left of urinary      4.00                               
  bladder - L                                                               

  Testis(es): Malpositioned - L          0.55                               

  Testis(es): Malpositioned - F          4.00                               

                                                                            

  NOTE: F - Fetus                                                           

  L - Litter                                                                

                                                                            
  -------------------------------------- ------ ----- ------- ------ ------ ------

L-7

**APPENDIX L - HISTORICAL CONTROL DATA FOR ANNANDALE, NJ FACILITY
(CONT'D)**

**(SKELETAL DATA)**

  ---------------------------------- ------- ------- ------- ------- ------ ------
  STUDY \#                           13      12      11      10      9(B)   9(A)

  NUMBER OF LITTER                   25      25      24      24      \$     \$

  NUMBER OF FETUSES                  192     194     177     181     \$     \$

  \% SKEL. VAR. - F                  17.80   15.46   15.25   8.84    \$     \$

  \% SKEL. VAR. - L                  76.00   60.00   54.17   50.00   \$     \$

                                                                            

  \% SKEL. MAL. - F                  0       0       1.13    0       \$     \$

  \% SKEL. MAL. - L                  0       0       8.33    0       \$     \$

                                                                            

  Sternebrae: Advanced - F           1.05                                   

  Sternebrae: Advanced - L           8.00                                   

  Sternebrae: Bifid - F              0.52                                   

  Sternebrae: Bifid - L              4.00                                   

  Sternebrae: Hypoplastic - F                1.03                           

  Sternebrae: Hypoplastic - L                4.00                           

  Sternebrae: Unossified - F         1.05            1.7     1.10           

  Sternebrae: Unossified - L         8.00            8.33    8.33           

  Sternebral anlage: Hypoplastic - F                 2.82                   

  Sternebral anlage: Hypoplastic - L                 12.50                  

  Vertebrae: Absent multiple - F                     0.56                   

  Vertebrae: Absent multiple - L                     4.17                   

  Vertebral centra: Bifid- F         5.76    10.82   6.78    1.10           

  Vertebral centra: Bifid- L         36.00   48.00   29.17   8.33           
  ---------------------------------- ------- ------- ------- ------- ------ ------

L-8

**APPENDIX L - HISTORICAL CONTROL DATA FOR ANNANDALE, NJ FACILITY
(CONT'D)**

**(SKELETAL DATA)**

  -------------------------------------- ------- ------- ------- ------- ------ ------
  STUDY \#                               13      12      11      10      9(B)   9(A)

  NUMBER OF LITTER                       25      25      24      24      \$     \$

  NUMBER OF FETUSES                      192     194     177     181     \$     \$

  Vertebral centra: Dumbbell/8-shaped -  0.52    0.52            1.10           
  F                                                                             

  Vertebral centra: Dumbbell/8-shaped -  4.00    4.00            8.33           
  L                                                                             

  Vertebral centra: Misshapen - F                        0.56                   

  Vertebral centra: Misshapen- L                         4.17                   

  Vertebral centra: Unossified - F                       0.56                   

  Vertebral centra: Unossified - L                       4.17                   

  Vertebrae: Supernumerary presacral     0.52            0.56                   
  Lumbar - F                                                                    

  Vertebrae: Supernumerary presacral     4.00            4.17                   
  Lumbar - L                                                                    

  Vertebral centra anlage: Bifid - F     0.52                                   

  Vertebral centra anlage: Bifid - L     4.00                                   

  Vertebral centra anlage: Dumbbell/8    5.24    1.55                           
  shaped - F                                                                    

  Vertebral centra anlage: Dumbbell/8    28.00   12.00                          
  shaped - L                                                                    

  Vertebral centra anlage: Hypoplastic -                 1.69                   
  F                                                                             

  Vertebral centra anlage: Hypoplastic -                 12.50                  
  L                                                                             

  Vertebral centra anlage: Misshapen - F                 0.56                   

  Vertebral centra anlage: Misshapen - L                 4.17                   

  Rib(s): Rudimentary lumbar - F         8.90    4.12    1.70    5.52           

  Rib(s): Rudimentary lumbar - L         40.00   24.00   12.50   25.00          

  Rib(s): Rudimentary thoracic - F       0.52                                   

  Rib(s): Rudimentary thoracic - L       4.00                                   

  Rib(s): Well formed lumbar - F         0.52                                   

  Rib(s): Well formed lumbar - L         4.00                                   
  -------------------------------------- ------- ------- ------- ------- ------ ------

L-9

**APPENDIX L - HISTORICAL CONTROL DATA FOR ANNANDALE, NJ FACILITY
(CONT'D)**

**(SKELETAL DATA)**

  ---------------------------------- ------ ------ ------- ------ ------ ------
  STUDY \#                           13     12     11      10     9(B)   9(A)

  NUMBER OF LITTER                   25     25     24      24     \$     \$

  NUMBER OF FETUSES                  192    194    177     181    \$     \$

  Rib(s) anlage: Hypoplastic - F                   2.82                  

  Rib(s) anlage: Hypoplastic - L                   12.50                 

  Rib(s) anlage: Site of                           1.13                  
  ossification - F                                                       

  Rib(s) anlage: Site of                           4.17                  
  ossification - L                                                       

                                                                         

  NOTE: F - Fetus                                                        

  L - Litter                                                             

  \$ - Not examined                                                      

                                                                         

                                                                         
  ---------------------------------- ------ ------ ------- ------ ------ ------

L-10

**APPENDIX M -- FEED AND WATER ANALYSES**

**FEED ANALYSES**

![](media/image4.jpeg){width="6.375in" height="8.25in"}

M-1

**APPENDIX M -- FEED AND WATER ANALYSES (CONT'D)**

**FEED ANALYSES**

![](media/image5.jpeg){width="6.375in" height="8.25in"}

M-2

**APPENDIX M -- FEED AND WATER ANALYSES (CONT'D)**

**WATER ANALYSES**

![](media/image6.jpeg){width="6.375in" height="8.25in"}

M-3

**APPENDIX M -- FEED AND WATER ANALYSES (CONT'D)**

**WATER ANALYSES**

![](media/image7.jpeg){width="5.615277777777778in"
height="7.6402777777777775in"}

M-4

**APPENDIX M -- FEED AND WATER ANALYSES (CONT'D)**

**WATER ANALYSES**

![](media/image8.jpeg){width="5.495138888888889in"
height="7.729861111111111in"}

M-5

**APPENDIX M -- FEED AND WATER ANALYSES (CONT'D)**

**WATER ANALYSES**

![](media/image9.jpeg){width="5.029861111111111in"
height="6.736805555555556in"}

M-6

**APPENDIX M -- FEED AND WATER ANALYSES (CONT'D)**

**WATER ANALYSES**

![](media/image10.jpeg){width="5.584722222222222in"
height="7.745138888888889in"}

M-7

**APPENDIX M -- FEED AND WATER ANALYSES (CONT'D)**

**WATER ANALYSES**

![](media/image11.jpeg){width="5.554861111111111in"
height="7.520138888888889in"}

M-8

**APPENDIX M -- FEED AND WATER ANALYSES (CONT'D)**

**WATER ANALYSES**

![](media/image12.jpeg){width="5.495138888888889in"
height="7.520138888888889in"}

M-9

**APPENDIX M -- FEED AND WATER ANALYSES (CONT'D)**

**WATER ANALYSES**

![](media/image13.jpeg){width="5.509722222222222in"
height="7.295138888888889in"}

M-10