Number range CHAPTER **CURRICULUM VITAE**

Richard A. Sams

**A.** **CURRENT TITLE/AFFILIATION**

> Professor and Director
>
> OSU Analytical Toxicology Laboratory
>
> College of Veterinary Medicine
>
> The Ohio State University

**B.** **ADDRESS**

> OSU Analytical Toxicology Laboratory
>
> OSU Veterinary Hospital
>
> 601 Tharp Street
>
> Columbus, Ohio 43210
>
> .......................................
>
> ......................

**C.** **EDUCATION**

> Doctor of Philosophy Degree awarded March 1975 by the Graduate School
> of The Ohio State University; major professor: Louis Malspeis; area of
> specialization: pharmaceutics and pharmacokinetics; dissertation
> title: \"Pharmacokinetics of naloxone in the dog\".
>
> Bachelor of Science Degree awarded June 1969 by the College of
> Pharmacy at The Ohio State University

**D.** **WORK HISTORY**

> **DATE POSITION OR TITLE INSTITUTION**
>
> 1990-present Professor Department of Veterinary Clinical Sciences,
> College of Veterinary Medicine, OSU

1990-present Professor Division of Pharmaceutics, College of Pharmacy,
OSU

> 1982-1990 Associate Professor Department of Veterinary Clinical
> Sciences, College of Veterinary Medicine, OSU
>
> 1976-1982 Assistant Professor Department of Veterinary Clinical
> Sciences, College of Veterinary Medicine, OSU
>
> 1979-present Director Analytical Toxicology Laboratory, OSU
>
> 1974 -1975 Senior Scientist Ciba-Geigy Corp., Suffern, NY

E.  **MEMBERSHIP IN PROFESSIONAL SOCIETIES**

> American Academy of Forensic Sciences
>
> American Academy of Veterinary Pharmacology and Therapeutics
>
> American Association of Pharmaceutical Scientists
>
> American Chemical Society
>
> American Pharmaceutical Association
>
> Association of Official Racing Chemists -- associate member
>
> Columbus Society for the Scientific Detection of Crime

F.  **COURSES TAUGHT**

> VPHYS 746 Bioanalytical Chemistry (graduate program)
>
> VMED 662 Respiratory System (professional veterinary curriculum)
>
> VMED 693 Clinical Pharmacology of Cardiovascular Drugs (graduate
> program)
>
> VMED 693 Research Methods (graduate program)
>
> PHARM 881 Bioanalytical Chemistry (graduate program)
>
> VMED 696 Biostatistics (graduate program)

G.  **DISSERTATIONS/THESES DIRECTED:**

> Major Professor/Dissertation Advisor for Dr. Timothy Dyke (1995)
>
> Major Professor/Dissertation Advisor for Meir Tzou (1994)
>
> Major Professor/Thesis Advisor for Dr. James M. Donecker (1984)
>
> Major Professor/Thesis Advisor for Ellen L. Harrington (1984)
>
> Major Professor/Thesis Advisor for Dr. Walter W. Ruoff, Jr. (1981)

H.  **SCHOLARLY ACTIVITIES:**

> Chairman, Testing Integrity Program, Inc., 2001-present
>
> Member, Testing Integrity Program, Inc., 1994-present
>
> Member, Editorial Board, *Journal of Veterinary Pharmacology and
> Therapeutics*, 1986 - present
>
> Member, Editorial Board, *American Journal of Veterinary Research*,
> 1987 - 1989
>
> Grant Reviewer, US Food and Drug Administration, 1989, 1993, 1994
>
> Grant Reviewer, US Department of Agriculture, 1993
>
> Grant Reviewer, Texas Equine Research Fund, 1993
>
> Grant Reviewer, National Institutes on Drug Abuse, 1989
>
> Program Committee Member, ARCI Quality Assurance Program, 1988 - 1992

I.  **UNIVERSITY ACTIVITIES:**

> Chairman, Graduate Studies Committee, Department of Veterinary
> Clinical Sciences, 1983 - 1993; 1997-present
>
> Elected Member, University Research and Graduate Council, 1992 - 1996
>
> Member, Research Committee, University Research and Graduate Council,
> 1994 - 1996
>
> Member, Curriculum Committee, University Research and Graduate
> Council, 1992 - 1994
>
> Member, Finley Center Management Committee, 1990 - 2002
>
> Director, OSU Analytical Toxicology Laboratory, 1979 - present

Member, College Promotion and Tenure Committee, 1995-1998

Member, Department Promotion and Tenure Committee, 1998-present.

# J. REFEREED PUBLICATIONS

1.  R.H. Reuning, R.A. Sams, and R.E. Notari (1973) Role of
    pharmacokinetics in drug dosage adjustment I. Pharmacologic effect
    kinetics and apparent volume of distribution of digoxin. *Journal of
    Clinical Pharmacology* **12**, 127-141.

> 2\. R.A. Sams and L. Malspeis (1976) Determination of naloxone and
> naltrexone as perfluoroalkyl ester derivatives by electron-capture
> GLC. *Journal of Chromatography* **125**, 409-420.

3.  R.A. Sams and J.D. Baggot (1977) Bioavailability, disposition
    kinetics and dosage of sulfadimethoxime in dogs - a correction.
    *Canadian Journal of Comparative Medicine* **41**, 479-480.

4.  Y.K. Fung, R.G. Rahwan, and R.A. Sams (1977) Separation of vitamin A
    compounds by thin-layer chromatography. *Journal of Chromatography*
    **147**: 528-531.

5.  H.D. Mercer, J.D. Baggot, and R.A. Sams (1977) Application of
    pharmacokinetics to the drug residue profile. *Journal of Toxicology
    and Environmental Health* **2**, 787-801.

6.  R.A. Sams and R.H. Huffman (1978) A thin-layer chromatographic test
    for reserpine in plasma. *Journal of Chromatography* **161**,
    410-419.

7.  R.A. Sams (1978) Determination of reserpine in plasma, using high
    performance liquid chromatography with fluorescence detection.
    *Analytical Letters* **B11**, 697-707.

8.  C.W. Kohn, W.W. Muir, and R.A. Sams (1978) Plasma volume and
    extracellular fluid volume in horses at rest and following exercise.
    *American Journal of Veterinary Research* **39**, 871-874.

9.  W.W. Muir, C.W. Kohn, and R.A. Sams (1978) Effects of furosemide on
    plasma volume and extracellular fluid volume in horses. *American
    Journal of Veterinary Research* **39**, 1688-1691.

10. R.H. Reuning, V.K. Batra, T.M. Ludden, M.Y. Jao, B.E. Morrison, D.A.
    McArthy, S.E. Harrigan, S.B. Ashcraft, R.A. Sams, M.S. Bathala, A.E.
    Staubus, and L. Malspeis (1979) Plasma naltrexone kinetics after
    intravenous bolus administration in dogs and monkeys. *Journal of
    Pharmaceutical Sciences* **68**, 411-416.

11. W.W. Muir, R.A. Sams, and R.H. Huffman (1980) Cardiopulmonary,
    behavioral and pharmacokinetic effects of propoxyphene in horses.
    *American Journal of Veterinary Research* **41**, 575-580.

12. J.A.E. Hubbell, W.W. Muir, and R.A. Sams (1980) Guaifenesin:
    cardiopulmonary effects and plasma concentrations in horses.
    *American Journal Veterinary Research* **41**, 1751-1756.

13. J.T. Robertson, W.W. Muir, and R.A. Sams (1981) Cardiopulmonary
    effects of butorphanol tartrate in horses. *American Journal of
    Veterinary Research* **42**, 41-44.

14. S.M. McGuirk, W.W. Muir, and R.A. Sams (1981) Pharmacokinetic
    analysis of intravenously and orally administered quinidine in
    horses. *American Journal of Veterinary Research* **42**, 938-942.

15. S.M. McGuirk, W.W. Muir, and R.A. Sams (1981) Pharmacokinetic
    analysis of intravenously and orally administered quinidine in cows.
    *American Journal of Veterinary Research* **42**, 1482-1487.

16. W.W. Muir, R.A. Sams, R.H. Huffman, and J.S. Noonan (1982)
    Pharmacodynamic and pharmacokinetic properties of diazepam in
    horses. *American Journal of Veterinary Research* **43**, 1756-1762.

17. S.M. McGuirk, W.W. Muir, R.A. Sams, and D.M. Rings (1983) Atrial
    fibrillation in cows: clinical findings and therapeutic
    considerations. *Journal of the American Veterinary Medical
    Association* **182**, 1380-1386.

18. W.W. Muir, R.A. Sams, and S.M. Ashcraft (1984) Pharmacologic and
    pharmacokinetic properties of methocarbamol in horses. *American
    Journal of Veterinary Research* **45**, 2256-2260.

19. R.A. Sams (1984) Principles of clinical pharmacokinetics of
    antimicrobial drugs. *Journal of the American Veterinary Medical
    Association* **185**, 1068-1971.

20. R.A. Sams and W.W. Ruoff (1985) Pharmacokinetics and bioavailability
    of cefazolin in horses. *American Journal of Veterinary Research*
    **46**, 348-352.

21. L.R. Soma, R. Sams, W. Duer, T. Tobin, C. Woodward, and J.
    McDonald (1985) Plasma and serum concentrations of phenylbutazone
    and oxyphenbutazone in racing Thoroughbreds 24 hours after treatment
    with various dosage regimens. *American Journal Veterinary Research*
    **46**, 932-938.

22. R.A. Sams, W.W. Muir, R. Detra, and E. Robinson (1985) Comparative
    pharmacokinetics and anesthetic effects of methohexital,
    pentobarbital, thiamylal, and thiopental in Greyhound and
    non-Greyhound dogs. *American Journal of Veterinary Research*
    **46**, 1677-1683.

23. W.W. Ruoff and R.A. Sams (1985) Pharmacokinetics and bioavailability
    of cephalothin in horses. *American Journal of Veterinary Research*
    **46**, 2085-2090.

24. D.F. Gerken and R.A. Sams (1985) Inhibitory effects of intravenous
    chloramphenicol sodium succinate on the disposition of
    phenylbutazone in horses. *Journal of Pharmacokinetics and
    Biopharmaceutics* **13**, 467-476.

25. S.P. Di Bartola, D.J. Chew, M.J. Tarr, and R.A. Sams (1985)
    Hemodialysis of a dog with acute renal failure. *Journal American
    Veterinary Medical Association* **186**, 1323-1326.

26. G.H. Spurlock, S.L. Landry, R. Sams, S. McGuirk, and W.W.
    Muir (1985) Effect of endotoxin administration on body fluid
    compartments in the horse. *American Journal of Veterinary Research*
    **46**, 1117-1120.

27. K.M. Wernette, J.A. Hubbell, W.W. Muir, and R.A. Sams (1986)
    Doxapram: cardiopulmonary effects in the horse. *American Journal of
    Veterinary Research* **47**, 1360-1362.

28. T.A. Shepard, J. Hui, A. Chandrasekaran, R.A. Sams, R. H. Reuning,
    L.W. Robertson, J.H. Caldwell, and R.L. Donnerberg (1986) Digoxin
    and metabolites in urine and feces: a fluorescence
    derivatization-high performance liquid chromatographic technique.
    *Journal of Chromatography* **380**, 89-98.

29. J.M. Donecker, R.A. Sams, and S.M. Ashcraft (1986) Pharmacokinetics
    of probenecid and the effect of oral probenecid on the
    pharmacokinetics of cefazolin in mares. *American Journal of
    Veterinary Research* **47**, 89-95.

30. E.P. Robinson, R.A. Sams, and W.W. Muir (1986) Barbiturate
    anesthesia in Greyhound and mixed-breed dogs: comparative
    cardiopulmonary effects, anesthetic effects, and recovery rates.
    *American Journal of Veterinary Research* **47**, 2105-2112.

31. R.A. Sams and P. Pizzo (1987) Detection and identification of
    ketamine and its metabolites in horse urine. *Journal of Analytical
    Toxicology* **11**, 58-62.

32. J.A.E. Hubbell, W.W. Muir, J.T. Robertson, and R.A. Sams (1987)
    Cardiovascular effects of intravenous sodium penicillin, sodium
    cefazolin, and sodium citrate in awake and anesthetized horses.
    *Veterinary Surgery* **16**, 245-250.

33. L.E. Mathes, G. Muschik, L. Demby, P. Polas, D.W. Mellini, H.J.
    Issaq, and R. Sams (1988) High performance liquid chromatographic
    determination of 2\',3\'-dideoxycitidine and
    3\'-azido-3\'-deoxythymidine in plasma using a column switching
    technique. *Journal of Chromatography* **432**, 346-351.

34. R.A. Sams and W.W. Muir (1988) Effects of phenobarbital on
    thiopental pharmacokinetics in greyhounds. *American Journal of
    Veterinary Research* **49**, 245-249.

35. Y. Rikihisa, S.M. Reed, R.A. Sams, J.C. Gordon, and C.I. Pretzman
    (1990). Serosurvey of horses with evidence of equine monocytic
    ehrlichiosis. *Journal of the American Veterinary Medical
    Association* **197**, 1327-1332.

36. C.L. Swenson, R.A. Sams, P.J. Polas, D.F. Michael, and L.E. Mathes
    (1990). Age-related differences in pharmacokinetics of
    phosphoformate in cats. *Antimicrobial Agents & Chemotherapy*
    **34**, 871-874.

37. C.E. Uboh, J.A. Rudy, L.R. Soma, M. Fennell, L. May, R.A. Sams, F.A.
    Railing, J. Shellenberger, and M. Kahler (1991). Characterization of
    bromhexine and ambroxol in equine urine: effect of furosemide on
    identification and confirmation. *Journal of Pharmaceutical &
    Biomedical Analysis* **9**, 33-39.

38. P.J. Polas, C.L. Swenson, R. Sams, C.M. Cheney, K.A Hayes, M.J.
    Tarr, G.J. Kociba, and L.E. Mathes (1990). In vitro and in vivo
    evidence that the antiviral activity of 2\',3\'-dideoxycytidine is
    target cell dependent in a feline retrovirus animal model.
    *Antimicrobial Agents & Chemotherapy* **34**, 1414-1421.

39. D.D. Gerken and R.A. Sams (1988) Pharmacokinetics of oxyphenbutazone
    in horses. *Journal of Veterinary Pharmacology and Therapeutics*
    **11**, 283-287.

40. R.M. Bednarski, R.A. Sams, L.J. Majors, and S. Ashcraft (1988)
    Reduction of the ventricular arrhythmogenic dose of epinephrine by
    ketamine administration in halothane-anesthetized cats. *American
    Journal of Veterinary Research* **49**, 350-355.

41. K.J. Varma, R.A. Sams, R.D. Lobell, and P.W. Lockwood (1991)
    Pharmacokinetics and efficacy of a new broad spectrum antibiotic,
    florfenicol in cattle. *Acta Veterinaria Scandanavica* - Supplement
    **87**, 102-104.

42. A.D. Jernigan, G.D. St. Jean, D.M. Rings, and R.A. Sams (1991)
    Pharmacokinetics of rifampin in adult sheep. *American Journal of
    Veterinary Research* **52**, 1626-1629.

43. M.V. Crisman, J.R. Wilke, R.A. Sams, and D.F. Gerken (1991)
    Concentrations of phenylbutazone and oxyphenbutazone in
    post-parturient mares and their neo-natal foals. *Journal of
    Veterinary Pharmacology and Therapeutics* **14**, 330-334.

44. R.A. Sams, R.L. Detra, and W.W. Muir (1992) Pharmacokinetics and
    metabolism of intravenous doxapram in horses. *Equine Veterinary
    Journal* **11**, 45-51.

45. W.W. Muir and R.A. Sams (1992) Effects of ketamine infusion on
    halothane minimal alveolar concentration in horses. *American
    Journal of Veterinary Research* **53**, 1802-1806.

46. W.W. Muir, R.A. Sams, and S.M. Ashcraft (1992) The pharmacology and
    pharmacokinetics of high-dose methocarbamol in horses. *Equine
    Veterinary Journal. Supplement* **11**, 41-44.

47. C.E. Uboh, L.R. Soma, J.A. Rudy, E. Morgan, K. Menringhausen, and R.
    Sams (1992) Plasma concentrations of furosemide versus specific
    gravity of urine in predicting dose of administration in race
    horses. *Research Communications in Chemical Pathology and
    Pharmacology* **77**, 201-208.

48. C.W. Kohn, R. Sams, J.J. Kowalski, J. Powers, and S. Wallace (1993)
    Pharmacokinetics of single intravenous and single and multiple dose
    oral administration of rifampin in mares. *Journal of Veterinary
    Pharmacology and Therapeutics* **16**, 119-131.

49. K.W. Hinchcliff, K.H. McKeever, W.W. Muir, and R.A. Sams (1993)
    Effect of furosemide and weight carriage on energetic responses of
    horses to incremental exertion. *American Journal of Veterinary
    Research* **54**, 1500-1504.

50. C.W. Kohn, R.A. Sams, J.J. Kowalski, J. Powers, and S.
    Wallace (1993) Pharmacokinetics of single intravenous and single and
    multiple dose oral administration of rifampin in mares. *Journal of
    Veterinary Pharmacology and Therapeutics* **16**, 119-131.

51. S.D. Semrad, R.A. Sams, O.N. Harris, and S.M. Ashcraft (1993)
    Effects of concurrent administration of phenylbutazone and flunixin
    meglumine on pharmacokinetic variables and *in vitro* generation of
    thromboxane B~2~ in mares. *American Journal of Veterinary Research*
    **54**, 1901-1905.

52. S.D. Semrad, J.T. McClure, R.A. Sams, and L.M. Kaminski (1993)
    Pharmacokinetics and effects of repeated administration of
    phenylbutazone in neonatal calves. *American Journal of Veterinary
    Research* **54**, 1906-1912.

53. J.R. Wilcke, M.V. Crisman, R.A. Sams, and D.F. Gerken (1993)
    Pharmacokinetics of phenylbutazone in neonatal foals. *American
    Journal of Veterinary Research* **54**, 2064-2067.

54. S.D. Semrad, R.A. Sams, and S.M. Ashcraft (1993) Pharmacokinetics of
    and serum thromboxane suppression by flunixin meglumine in healthy
    foals during the first month of life. *American Journal of
    Veterinary Research* **54**, 2083-2087.

55. R.A. Sams (1993) Chemical assay of avermectins by high performance
    liquid chromatography with fluorescence detection. *Veterinary
    Parasitology* **48**, 59-66.

56. B. Martinsen, T.E. Horsberg, K.J. Varma, and R.A. Sams (1993) Single
    dose pharmacokinetic study of florfenicol in Atlantic salmon (*Salmo
    salar*) in seawater at 11C. *Aquaculture* **112**, 1-11.

57. K.H. McKeever, K.W. Hinchcliff, D.F. Gerken, and R.A. Sams (1993)
    Effects of cocaine on incremental treadmill exercise in horses.
    *Journal of Applied Physiology* **75**, 2727-2733.

58. R.D. Lobell, K.J. Varma, J.C. Johnson, R.A. Sams, D.F. Gerken, and
    S.M. Ashcraft (1994) Pharmacokinetics of florfenicol following
    intravenous and intramuscular doses to cattle. *Journal of
    Veterinary Pharmacology and Therapeutics* **17**, 253-258.

59. R.A. Sams, D.F. Gerken, and S.M. Ashcraft (1995) Pharmacokinetics of
    ketoprofen after multiple intravenous doses in horses. *Journal of
    Veterinary Pharmacology and Therapeutics* **18**, 108-116.

60. L.A. Mitten, K.W. Hinchcliff, and R.A. Sams (1995) A portable blood
    gas analyzer for equine blood. *Journal of Veterinary Internal
    Medicine* **9**, 353-356.

61. S.D. Stanley, R.A. Sams, J.D. Harkins, G.D. Mundy, J. Boyles, W.E.
    Woods, and T. Tobin (1995) Frequency distribution of post race urine
    pH from standardbreds compared with thoroughbreds: research and
    regulatory significance. *Equine Veterinary Journal* **27**,
    471-473.

62. J.D. Harkins, S.D. Stanley, G.D. Mundy, R.A. Sams, W.E. Woods,
    and T. Tobin (1995) A review of the pharmacology, pharmacokinetics,
    and regulatory control in the US of local anesthetics in the horse.
    *Journal of Veterinary Pharmacology and Therapeutics* **18**,
    397-406.

63. K.W. Hinchcliff, K.H. McKeever, W.W. Muir, and R.A. Sams (1995)
    Pharmacologic interaction of furosemide and phenylbutazone in
    horses. *American Journal of Veterinary Research* **5**6, 1206-1212.

64. M.C. Tzou, R.A. Sams, and R.H. Reuning (1995) Specific and sensitive
    determination of digoxin and metabolites in human serum by high
    performance liquid chromatography with cyclodextrin solid-phase
    extraction and pre-column fluorescence derivatization. *Journal of
    Pharmaceutical and Biomedical Analysis* **13**, 1531-1540.

65. R.P. Herd, R.A. Sams, and S.M. Ashcraft (1996) Persistence of
    ivermectin in plasma and feces following treatment of cows with
    ivermectin sustained-release, pour-on or injectable formulations.
    *International Journal for Parasitology* **26**, 1087-1093.

66. T.M. Dyke, K.W. Hinchcliff, R.A. Sams, K.H. McKeever, and W.W.
    Muir (1996) The effects of submaximal exercise on the
    pharmacokinetics of furosemide in horses. *Journal of Veterinary
    Pharmacology and Therapeutics* **19**, 164-166.

67. R.A. Sams, D.F. Gerken, R.A. Detra, S.D. Stanley, W.E. Wood, T.
    Tobin, J.-M. Yang, H.-H. Tai, A. Jegananthan, and D.S. Watt (1996)
    Identification of metabolites of azaperone in horse urine, *Journal
    of Pharmaceutical Sciences* **85**, 79-84.

68. J.D. Lillich, A.L. Bertone, L.M. Schmall, A.J. Ruggles, and R.A.
    Sams (1996) Plasma, urine, and synovial fluid disposition of
    methylprednisolone acetate and isoflupredone acetate after
    intra-articular administration. *American Journal of Veterinary
    Research* **57**, 187-192.

69. W.W. Muir, R.A. Sams, and S.F. Schall (1996) Haemodynamic,
    electrocardiographic, electrophysiologic and pharmacokinetic
    activity of 4\'-hydroxypropranolol in dogs. *Journal of Veterinary
    Pharmacology and Therapeutics* **19**, 259-267.

70. J.D. Harkins, G.D. Mundy, S. Stanley, W.E. Woods, R.A. Sams, D.R.
    Richardson and T. Tobin (1996) Character and duration of
    pharmacological effects of intravenous isoxsuprine. *Equine
    Veterinary Journal* **28**, 320-326.

71. K.W. Hinchcliff, K.H. McKeever, W.W. Muir, and R.A. Sams (1996)
    Furosemide reduces accumulated oxygen deficit in horses during brief
    intense exertion. *Journal of Applied Physiology* **81**, 1550-1554.

72. J.D. Harkins, G.D. Mundy, S. Stanley, W.E. Woods, J. Boyles, R.A.
    Arthur, R.A. Sams, and T. Tobin (1996) Regulatory significance of
    procaine residues in plasma and urine samples: preliminary
    communication. *Equine Veterinary Journal* **28**, 121-125.

73. M.V. Crisman, J.R. Wilcke, and R.A. Sams (1996) Pharmacokinetics of
    flunixin meglumine in healthy foals less than twenty-four hours old.
    *American Journal of Veterinary Research* **57**: 1759-1761.

74. R.A. Sams, D.F. Gerken, and S.M. Ashcraft (1997) Pharmacokinetics of
    intravenous and oral prethcamide in horses. *Journal of
    Pharmaceutical and Biomedical Analysis* **15**: 639-651.

75. G. Jacobs, T. Whittem, R.A. Sams, C. Calvert, and D. Ferguson (1997)
    Pharmacokinetics of propranolol in healthy cats during euthyroid and
    hyperthyroid states. *American Journal of Veterinary Research*
    **58**: 398-403.

76. L.J. Rivas, K.W. Hinchcliff, C.W. Kohn, R.A. Sams, and D.J.
    Chew (1997) Effect of sodium bicarbonate administration on renal
    function of horses. *American Journal of Veterinary Research*
    **58**: 664-671.

77. J.A. Hubbell, K.W. Hinchcliff, W.W. Muir, J.T. Robertson, and R.A.
    Sams (1997) Cardiorespiratory and metabolic effects of walking,
    standing, and standing with a splint during the recuperative period
    from maximal exercise in horses. *American Journal of Veterinary
    Research* **58**: 1003-1009.

78. M.C. Tzou, R.H. Reuning, and R.A. Sams (1997) Quantitation of
    interference in digoxin immunoassay in renal, hepatic, and diabetic
    disease. *Clinical Pharmacology and Therapeutics* **61**: 429-441.

79. T.M. Dyke, R.A. Sams, S.B. Cosgrove (1997) Disposition of flunixin
    after intramuscular administration to horses. *Journal of Veterinary
    Pharmacology and Therapeutics* **20**: 330-332.

80. R.A. Sams, D.F. Gerken, T.M. Dyke, S.M. Reed, and S.M.
    Ashcraft (1997) Pharmacokinetics of intravenous and intragastric
    cimetidine in horses. *Journal of Veterinary Pharmacology and
    Therapeutics* **20**: 355-361.

81. J.D. Harkins, G.D. Mundy, S.D. Stanley, R.A. Sams, and T.
    Tobin (1997) Lack of local anaesthetic efficacy of Sarapin in the
    abaxial sesamoid block model. *Journal of Veterinary Pharmacology
    and Therapeutics* **20**, 229 - 232.

82. L.J. Rivas, K.W. Hinchcliff, C.W. Kohn, R.A. Sams, and D.J.
    Chew (1997) Effect of sodium bicarbonate administration on blood
    constituents of horses. *American Journal of Veterinary Research*
    **58**: 658-663.

83. S.O. Wagner, R.A. Sams, and M. Podell (1998) Chronic phenobarbital
    therapy reduces plasma benzodiazepine concentrations after
    intravenous and rectal administration the dog. *Journal of
    Veterinary Pharmacology and Therapeutics* **21**, 335 - 341.

84. C.R. Short, R.A. Sams, L.R. Soma, T. Tobin (1998) The regulation of
    drugs and medicines in horse racing in the United States. The
    Association of Racing Commissioners International Uniform
    Classification of Foreign Substances Guidelines. *Journal of
    Veterinary Pharmacology and Therapeutics* **21**,145-153.

85. J.D. Harkins, G.D. Mundy, S. Stanley, W.E. Woods, R.A. Sams, D.R.
    Richardson, S.C. Grambow, and T. Tobin (1998). Absence of detectable
    pharmacological effects after oral administration of isoxsuprine.
    *Equine Veterinary Journal* **30**, 294-299.

86. T.M. Dyke and R.A. Sams (1998). Detection and determination of
    theobromine and caffeine in urine after administration of
    chocolate-coated peanuts to horses. *Journal of Analytical
    Toxicology* **22**, 112-116.

87. J.R. Wilcke, M.V. Crisman, W.K. Scarratt, and R.A. Sams (1998).
    Pharmacokinetics of ketoprofen in healthy foals less than
    twenty-four hours old. *American Journal of Veterinary Research*
    **59**, 290-292.

88. T.M. Dyke, R.A. Sams, and K.W. Hinchcliff (1998). Antipyrine
    pharmacokinetics and urinary excretion in female horses. *American
    Journal of Veterinary Research* **59**, 280-285.

89. T.M. Dyke, R.A. Sams, and K.W. Hinchcliff (1998).
    Intensity-dependent effects of acute submaximal exercise of the
    pharmacokinetics of bromsulphalein in horses. *American Journal of
    Veterinary Research* **59**, 1481-1487.

90. T.M. Dyke, R.A. Sams, K.G. Thompson, and S.M. Ashcraft (1998).
    Pharmacokinetics of multiple-dose administration of eltenac in
    horses. *American Journal of Veterinary Research* **59**, 1447-1450.

91. T.M. Dyke, J.A.E. Hubbell, R.A. Sams, and K.W. Hinchcliff (1998).
    Hepatic blood flow in horses during the recuperative period from
    maximal exercise. *American Journal of Veterinary Research* **59**,
    1476-1480.

92. T.M. Dyke, R.A. Sams, and K.W. Hinchcliff (1998). Exercise-training
    induced alterations in hepatic function in mares. *Journal of
    Applied Physiology* **85**, 1442-1447.

93. T.M. Dyke, J.A.E. Hubbell, D.A. Grosenbaugh, W. Beard, L. Mitten,
    R.A. Sams, K.W. Hinchcliff (1998) The pharmacokinetics of furosemide
    in anesthetized horses after bilateral ureteral ligation. *Journal
    of Veterinary Pharmacology and Therapeutics* **21**, 298-303.

94. M. Podell, S.O. Wagner, and R.A. Sams (1998) Lorazepam
    concentrations in plasma following its intravenous and rectal
    administration in dogs. *Journal of Veterinary Pharmacology and
    Therapeutics* **21**, 158-160.

95. T.M. Dyke, K.W. Hinchcliff, and R.A. Sams (1999). Attenuation by
    phenylbutazone of the renal effects and excretion of frusemide in
    horses. *Equine Veterinary Journal* **31**:289-295.

96. J.A.E. Hubbell, K.W. Hinchcliff, M. Schmall, W.W. Muir, J.T.
    Robertson, and R.A. Sams (1999) Cardiorespiratory and metabolic
    effects of xylazine, detomidine, and a combination of xylazine and
    acepromazine administered after exercise in horses. *American
    Journal of Veterinary Research* **60**: 1271-1279.

97. R.A. Sams, D.F. Gerken, and S.M. Ashcraft (1999) Detection and
    identification of flunixin after multiple intravenous and
    intramuscular administration doses to horses. *Journal of Analytical
    Toxicology* **23**: 372-379.

98. Number range CHAPTERT. Tobin, J.D. Harkins, and R.A. Sams (1999)
    Testing for therapeutic medications: analytical/pharmacological
    relationships and "limitations" on the sensitivity of testing for
    certain agents. *Journal of Veterinary Pharmacology and
    Therapeutics* **22**, 220-233.

99. M.D. Barnhart, J.A.E. Hubbell, W.W. Muir, R.A. Sams, and R.M.
    Bednarski (2000) Pharmacokinetics, pharmacodynamics, and analgesic
    effects of morphine after rectal, intramuscular, and intravenous
    administration in dogs. *American Journal of Veterinary Research*
    **61**: 24-28.

100. R.J. Geor, K.W. Hinchcliff, and R.A. Sams (2000) β-Adrenergic
     blockade augments glucose utilization in horses during graded
     exercise. *Journal of Applied Physiology* **89**: 1086-1098.

101. R.J. Geor, K.W. Hinchcliff, L. J. McCutcheon and R.A. Sams (2000)
     Epinephrine inhibits exogenous glucose utilization in exercising
     horses. *Journal of Applied Physiology* **88**: 1777-1790.

102. R.J. Geor, K.W. Hinchcliff, and R.A. Sams (2000) Glucose infusion
     attenuates endogenous glucose production and enhances glucose use
     of horses during exercise. *Journal of Applied Physiology* **88**:
     1765-1776.

103. J.A.E. Hubbell, K.W. Hinchcliff, L.M. Schmall, W.W. Muir, J.T.
     Robertson, R.A. Sams (2000) Anesthetic, cardiorespiratory, and
     metabolic effects of four anesthetic regimens administered
     intravenously after maximal exercise in horses. *American Journal
     of Veterinary Research* **61**: 1-8.

104. L.M. Dickow, D.F. Gerken, R.A. Sams, and S.M. Ashcraft (2001)
     Simultaneous determination of 2,4-D and MCPA in canine plasma and
     urine by HPLC with fluorescence using 9-anthryldiazomethane (ADAM).
     *Journal of Analytical Toxicology* **25**, 35-39.

105. W.W. Muir, R.A. Sams, J.A.E. Hubbell, K.W. Hinchcliff, and J.
     Gadawski (2001) Effects of enalaprilat on cardiorespiratory,
     hemodynamic, and hematologic variables in exercising horses.
     *American Journal of Veterinary Research* **62**: 1008-1013.

106. R.E. Toribio, C.W. Kohn, D.J. Chew, R.A. Sams, and T.J.
     Rosol (2001) Comparison of serum parathyroid hormone and ionized
     calcium and magnesium concentrations and fractional urinary
     clearance of calcium and phosphorus in healthy horses and horses
     with enterocolitis. *American Journal of Veterinary Research*
     **62**: 938-947.

107. E. Jose-Cunilleras, K.W. Hinchcliff, R.A. Sams, S.T. Devor,
     and J. K. Linderman (2002) Glycemic index of a meal fed before
     exercise alters substrate use and glucose flux in exercising
     horses. *Journal of Applied Physiology* **92**: 117-128.

108. P.A. March, M. Podell, and R.A. Sams (2002) Pharmacokinetics and
     toxicity of high-dose oral potassium bromide administration in
     Beagles. *Journal of Veterinary Pharmacology and Therapeutics*
     **25**, 425-432.

109. R.E. Toribio, C. W. Kohn, R.A. Sams, C.C Capen, and T.J.
     Rosol (2003) Hysteresis and calcium set-point for the calcium
     parathyroid hormone relationship in healthy horses. *General and
     Comparative Endocrinology* **130**: 279-288.

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K.  **RESEARCH SUPPORT:**

Title of Project: Specific assay for cardiac glycosides by ECD-GLC and
HPLC

Source of Funding: American Heart Association, Central Ohio Chapter

Amount of Funding: .......

Grant Period: 1980-1981

Principal Investigator: Richard Sams

Title of Project: Determination of dipyridamole in plasma samples

Source of Funding: Boehringer-Ingelheim Pharmaceuticals

Amount of Funding: ........

Grant Period: 1981-1985

Principal Investigator: Richard Sams

Title of Project: Chloramphenicol effects on phenylbutazone metabolism
and disposition in the horse

Source of Funding: College of Vet. Med., Equine Research Grant

Amount of Funding: ......

Grant Period: 1983

Co-investigators: Diane Gerken and Richard Sams

Title of Project: Pharmacokinetics of cefazolin and cephalothin in the
horse

Source of Funding: College of Vet. Med., Equine Research Grant

Amount of Funding: .......

Grant Period: 1980-1981

Principal Investigator: Richard Sams

Title of Project: Pharmacokinetics of probenecid and its effects on the
pharmacokinetics of cefazolin in horses

Source of Funding: College of Vet. Med., Equine Research Grant

Amount of Funding: .......

Grant Period 1982-1983

Principal Investigator: Richard Sams

Title of Project: Cefadroxil and cephalexin comparative pharmacokinetic
study in the horse

Source of Funding: Bristol Laboratories

Amount of Funding: ......

Grant Period: 1983-1984

Principal Investigator: Richard Sams

Title of Project: Effects of oxyphenbutazone on the pharmacokinetics of
phenylbutazone in horses

Source of Funding: College of Vet. Med., Equine Research Grant

Amount of Funding: ......

Grant Period: 1985-1986

Co-investigators: Diane Gerken and Richard Sams

Title of Project: Determination of We-941 in human plasma samples

Source of Funding: Boehringer-Ingelheim Pharmaceuticals

Amount of Funding: .......

Grant Period: 1985-1986

Principal Investigator: Richard Sams

Title of Project: Determination of mazindol metabolites in horses

Source of Funding: American Horse Shows Assoc.

Amount of Funding: .......

Grant Period: 1985-1986

Principal Investigator: Richard Sams

Title of Project: Determination of prethcamide in horses

Source of Funding: American Horse Shows Assoc.

Amount of Funding: .......

Grant Period: 1985-1986

Principal Investigator: Richard Sams

Title of Project: ^14^C-Phenylbutazone elimination in horses

Source of Funding: College of Vet. Med., Equine Research Grant

Amount of Funding: .......

Grant Period: 1986-1989

Co-investigators: Diane Gerken and Richard Sams

Title of Project: Vitamin K Bioavailability and Vitamin K therapy in
brodifacoum toxicosis

Source of Funding: College of Vet. Med., Canine Research Grant

Amount of Funding: .......

Grant Period: 1986-1987

Co-investigators: Diane Gerken and Richard Sams

Title of Project: Vitamin K Bioavailability during brodifacoum toxicosis

Source of Funding: American. Animal Hosp. Assoc. and Ohio Animal Health
Foundation

Amount of Funding: ......

Grant Period: 1987-1988

Co-investigators: Diane Gerken and Richard Sams

Title of Project: Xenobiotic metabolism in isolated horse hepatocytes

Source of Funding: College of Vet. Med., Equine Research Grant

Amount of Funding: ......

Grant Period: 1988-1989

Co-investigators: Joyce Griffiths, Diane Gerken, and Richard Sams

Title of Project: Immunoaffinity extraction of dexamethasone from horse
urine

Source of Funding: College of Vet. Med., Equine Research Grant

Amount of Funding: .......

Grant Period: 1988-1989

Co-investigators: Diane Gerken and Richard Sams

> Title of Project: Detection of flunixin after multiple dose
> administration
>
> Source of Funding: Schering-Plough Animal Health
>
> Amount of Funding: ......
>
> Grant Period: 1993-1994
>
> Investigator: Richard Sams
>
> Title of Project: Determination of eltenac in test samples collected
> from horses
>
> Source of Funding: Schering Plough Animal Health
>
> Amount of Funding: ......
>
> Grant Period: 1993-1994
>
> Investigator: Richard Sams
>
> Title of Project: Effects of acute and chronic exercise on hepatic
> function in horses
>
> Source of Funding: College of Vet. Med. Equine Research Grant
>
> Amount of Funding: .......
>
> Grant Period: 1994-1995
>
> Co-investigators: Timothy Dyke and Richard Sams
>
> Title of Project: Development of confirmation methods for detomidine
> administration to the horse
>
> Source of Funding: Racing Commissioners International, Inc.
>
> Amount of Funding: .......
>
> Grant Period: 1994-1995
>
> Co-investigators: Richard Sams
>
> Title of Project: Development of confirmation methods for medetomidine
> administration to the horse
>
> Source of Funding: Racing Commissioners International, Inc.
>
> Amount of Funding: .......
>
> Grant Period: 1995-1996
>
> Co-investigators: Diane Gerken and Richard Sams

**L. CONTINUING EDUCATION**

> Pharmacokinetics for Pharmaceutical Scientists, University of
> California at San Francisco, San Francisco, California, February,
> 1989.
>
> Forensic Urine Drug Testing, University of Utah, Salt Lake City, Utah,
> February 1990.
>
> Achieving Accreditation for Your Laboratory, A2LA, Washington, D.C.,
> October 1991.

M.  **CONSULTATION**

> Consultant or expert witness for racing commissions in Washington,
> California, Louisiana, Oklahoma, Kentucky, Texas, Minnesota,
> Pennsylvania, West Virginia, Nebraska, and Ohio
>
> Expert witness for Drug Enforcement Administration in Miami, Florida
> and Columbus, Ohio and for the American Horse Shows Association
>
> Consultant for Industrial Laboratories Inc., Merck, Schering-Plough
> Animal Health, Heska, Ciba-Geigy Corporation, and Hoechst-Roussel
> Animal Health
>
> Consultant to the Medication Research and Testing Consortium -- 2001
> -- present.

N.  **OTHER SUPPORT**

> The Ohio State University Analytical Toxicology Laboratory is the
> official testing laboratory of the Ohio State Racing Commission and
> has served in that capacity since 1965. The laboratory annually tests
> approximately 37,000 blood and urine samples collected from horses
> racing at seven commercial racetracks and at approximately sixty
> county fairs in Ohio. The samples are tested for the presence of drugs
> prohibited by the Ohio State Racing Commission. Laboratory staff
> members work closely with commission veterinarians, racing
> commissioners and staff persons, and with the Ohio Attorney General\'s
> office to carry out its role as the official laboratory of the
> Commission. As a result of this effort the OSU College of Veterinary
> Medicine is awarded research funds (........ in 2001) for research on
> the horse.

Title of Project: Analysis of Blood and Urine Samples from Racehorses

Source of Funding: Ohio State Racing Commission

Amount of Funding: approximately ........... (annual budget in excess of
...........in 2002-2003)

Contract Period: 1979-2003

Project Director: Richard Sams

> The Ohio State University Analytical Toxicology Laboratory is the
> official testing laboratory of the Ohio Department of Agriculture and
> has served in that capacity since 1995. The laboratory annually tests
> approximately 1,000 hair and urine samples collected from livestock
> entered in livestock shows at county fairs and the Ohio State Fair.
> The samples are tested for the presence of drugs prohibited by state
> law. Laboratory staff members work closely with Department of
> Agriculture veterinarians and staff persons, fair officials and fair
> veterinarians, and with the Ohio Attorney General\'s office to carry
> out its role as the official laboratory.

Title of Project: Analysis of Hair and Urine Samples from Livestock

Source of Funding: Ohio Department of Agriculture

Amount of Funding: approximately .......... (annual budget of about
........)

Contract Period: 1995-2003

Project Director: Richard Sams

> The Ohio State University Analytical Toxicology Laboratory was
> designated one of two Research and Reference Centers for the national
> Uniform Drug Testing and Quality Assurance Program of the National
> Association of State Racing Commissioners (NASRC) in 1981. OSU
> Analytical Toxicology Laboratory developed new methods for detecting
> drugs in horse samples, prepared proficiency and blind test samples
> for other laboratories participating in the program, conducted
> research on the pharmacokinetics and metabolism of drugs in horses,
> and evaluated test procedures and data submitted by other
> laboratories. From 1988-1992, the Ohio laboratory was the only
> Research and Reference Center of a new Quality Assurance Program
> organized by the Association of Racing Commissioners International
> (ARCI). The activities of the laboratory under this new program were
> similar to those under the older program but were broader in scope.

Title of Project: NASRC/ARCI Quality Assurance Program

Source of Funding: National Association of State Racing
Commissioners/Association of Racing Commissioners International, Inc.

Amount of Funding: ..........

Contract Period: 1981-1992

Project Director: Richard Sams