**October, 2005**

[CURRICULUM VITAE]{.underline}

[Name]{.underline}: Chou-Chi H. Li, Ph.D.

[Citizenship]{.underline}: United States

[Education]{.underline}:

1973 B.S., Botany/Biology, National Taiwan University, Taipei, Taiwan

1975 M.S., Cell Biology, University of Pittsburgh, Pittsburgh, PA

1988 Ph.D., Molecular Virology, Johns Hopkins University, Baltimore, MD

[Brief Chronology of Employment]{.underline}:

1973-1975 Teaching Assistant, University of Pittsburgh, Pittsburgh, PA

1976-1977 Teaching Assistant, Upstate Medical Center, State University
of New York,

Syracuse, NY

1979-1981 Research Assistant, Molecular Biology of Retroviruses Section,

NCI - Frederick Cancer Research Center, Frederick, MD

1981-1982 Research Associate, Gene Expression Section, Genex
Corporation, Gaithersburg, D

1982-1988 Research Associate, Biological Carcinogenesis Program,
NCI-Frederick Cancer, Rsearch Center, Frederick, MD

1988-Date Scientist, Sr. Scientist, and Principal Scientist, NCI at
Frederick, Frederick, MD

[Societies]{.underline}:

Phi Beta Kappa

Sigma Xi

Delta Omega

American Association for the Advancement of Science

Society of Chinese Bioscientists in America

American Society of Cell Biology

American Association for Cancer Research

American Society for Biochemistry and Molecular Biology

[Honors and Other Scientific Recognition]{.underline}:

1\. SAIC Executive Science and Technology Award for Best Research Paper

2\. SAIC Outstanding Scientific Achievement Award

3\. Phi Beta Kappa Honorary Society Award

4\. Dr. Sun Yishen Honor Student Award

5\. National Taiwan University Top Honor Student Award

6\. Ad Hoc Reviewer: J. Biological Chemistry, Oncogene, Blood,
Biochemical J., etc.

7\. Co-Inventor of "The G-protein coupled receptor FPRL1 as a target for
developing therapeutic agents for Alzheimer's disease" with Ji Ming
Wang, et al. (Patent applied)

8\. Binational Science Foundation grant: "The AAA-ATPase p97/Cdc48p and
the endoplasmic reticulum-associated protein degradation"; PI: S.
Bar-Nun and C.-C.H. Li, 2003-2005.

[Publications]{.underline}:

1\. Number range CHAPTERGonda, M. A., Young, H. A., Elser, J. E.,
Rasheed, S., Talmadge, C. B., Nagashima, K., Li, C.-C. H., and Gilden,
R.V.: Molecular cloning, genomic analysis and biological properties of
rat leukemia virus and the onc sequences of Rasheed rat sarcoma virus.
*J. Virol*. 44: 520-529, 1982.

2\. Arthur, R. R., Beckman, A. M., Li, C.-C. H., Saral, R., and Shah, K.
V.: Direct detection of the human papovavirus BK in urine of bone marrow
transplant recipients: comparison of DNA hybridization with ELISA. *J.
Med. Virol*. 16: 29-36, 1985.

3\. Li, C-C. H., Shah, K. V., Seth, A., and Gilden, R. V.:
Identification of the human papillomavirus type 6b L1 open reading frame
protein in condylomas and corresponding antibodies in human sera. *J.
Virol.* 61: 2684-2690, 1987.

4\. Li, C-C. H., Gilden, R. V., Showalter, S. D. and Shah, K.V.:
Identification of the human papillomavirus E2 protein in genital tract
tissues. *J. Virol**. *** 62: 606-609, 1988.

5\. Li, C-C. H., Shah, K. V., and Gilden, R. V.: E2 open reading frame
proteins are detected in cervical carcinoma-derived cell lines. In
Howley, P. and Broker, T. (Eds.): *Papillomaviruses*, New York, Alan R.
Liss, Inc., 1989, pp 119-134.

6\. Ferris, D. K., White, G., Kelvin, D. J., Copeland, T. D., Li, C-C.
H., and Longo, D. L.: p34^cdc2^ is physically associated with and
phosphorylated by a cdc2-specific tyrosine kinase. *Cell Growth & Diff.*
2: 343-349, 1991.

7\. Li, C-C. H., Chen, E., O\'Connell, C. D., and Longo, D. L.:
Detection of c-mos proto-oncogene expression in human cells. *Oncogene*
8: 1685-1691, 1993.

8\. Li, C-C. H., Ruscetti, F. W., Rice, N. R., Chen, E., Yang, N-S.,
Mikovits, J., and Longo, D. L.: Differential expression of Rel family
members in human T-cell leukemia virus type I-infected cells:
transcriptional activation of c-rel by Tax protein. *J. Virol.* 67:
4205-4213, 1993.

9\. Li, C.-C. H., Ruscetti, F. W., Rice, N. R., Chen, E., Yang, N.-S.,
Mikovits, J. and Longo, D. L.: Differential expression of Rel family
members in HTLV-I infected cells: Evidence for transcriptional
activation of c-Rel by TAX protein. *J. Cell. Biochem*. suppl. 17A: 146,
1993.

10\. Li, C.-C. H., Dai, R.-M., and Longo, D. L.: p53 physically
associates with Cdk2 in a cell cycle-dependent manner. *J. Cell.
Biochem*., suppl. 18C: 196, 1994.

11\. Li, C-C. H., Korner, M., Ferris, D. K., Chen, E., Dai, R-M., and
Longo, D. L.: NF-κB/Rel family members are physically associated
phosphoproteins. *Biochem. J*. 303: 499-506, 1994.

12\. Li, C-C. H., Dai, R-M., Chen, E., and Longo, D. L. Phosphorylation
of NFKB1-p50 is involved in NF-κB activation and stable DNA binding. *J.
Biol. Chem*. 269: 30089-30092, 1994.

13\. Li, C-C. H., O\'Connell, C. D., Beckwith, M., and Longo, D. L.
Detection of p53 mutations in B-cell Non-Hodgkin\'s lymphoma cell lines.
*Leukemia* 9: 650-655, 1995.

14\. Li, C-C. H., Dai, R-M., and Longo, D. L. Inactivation of NF-kB
inhibitor IkBa: ubiquitin-dependent proteolysis and its degradation
product. *Biochem. Bioph. Res. Comm*. 215: 292-301, 1995.

15\. Zhu, T., Kang, L., Wen, L., Li, C-C. H., Yang, L., and Yang, Y-C.
Multiple transcription factors are required for activation of human
interleukin-9 gene in T-cells. *J. Biol. Chem*. 271: 15815-15822, 1996.

16\. Kim, I. K., Li, C-C. H., Young, H. A., Lee, J. H., Kim, H. S.,
Pardhasaradhi, K., Garcia, G. E., and Chiang, P. K. Apoptosis of L1210
leukemia cells induced by 3-deazaadenosine analogs: differential
expression of c-*myc*, NF-Kappa B and molecular events. *J. Biomed.
Sci*. 4: 83-90, 1997.

17\. Dai, R-M., Chen, E., Longo, D. L., Gorbea, C. M., and Li, C-C. H.
Involvement of Valosin-containing protein, an ATPase co-purified with
IκBα and 26S proteasome, in ubiquitin-proteasome-mediated degradation of
IκBα. *J. Biol. Chem*. 273: 3562-3573, 1998.

18\. Chen, E., and Li, C.-C. H. Association of Cdk2/Cyclin E and NF-kB
complexes at G1/S phase. *Biochem. Biophy. Res. Commun.* 249: 728-734,
1998.

19\. Chen, E., Hrdlickova, R., Jiri Nehyba, Longo, D. L., Bose, H. R.,
and Li, C-C. H.: Degradation of proto-oncoprotein c-Rel is regulated by
the ubiquitin-proteasome proteolytic pathway. *J. Biol. Chem.* 273:
35201-35207, 1998.

20\. Ferris, D. K., Maloid, S. C., and Li, C-C. H. Ubiquitin-dependent
proteasome mediated degradation of Polo-like-kinase at G2/M phase
transition. *Biochem. Biophy. Res. Commun.* 252: 340-344, 1998.

21\. Yen, C.-H., Ynag, Y.-C., Ruscetti, S. K., Kirken, R. A., and Li,
C.-C. H. Involvement of ubiquitin-proteasome pathway in the degradation
of non-tyrosine kinase type cytokine receptors of interleukin-9,
interleukin-2 and erythropoietin. *J. Immunol.* 165: 6372-6380, 2000.

22\. Yazawa, H., Yu, Z.-X., Takeda, K., Le, Y., Gong, W., Ferrans, V.,
Li, C.-C. H., and Wang, J. M. The G-protein coupled receptor FPRL1
mediates internalization of Aβ~42~. *FASEB J*. 15, 2454-2462, 2001.

23\. Dai, R. M., and Li, C.-C. H Valosin-containing-protein is a
multi-ubiquitin chain-targeting factor required in the
ubiquitin-proteasome degradation pathway. *Nature Cell Biol*. 3,
740-744, 2001.

24\. Maurizi, M., and Li, C.-C. H. AAA proteins: in search of a common
molecular Basis. *EMBO Rep*. 2, 980-985, 2001.

25\. Wang, Q., Song, C., and Li, C.-C. H. Hexamerization of p97-VCP is
promoted by ATP binding to the D1 domain and required for ATPase and
biological activities. *Biochem. Biophy. Res. Commun*.300, 253-260,
2003.

26\. Song, C., Wang, Q, and Li, C.-C. H. ATPase activity of
p97-Valosin-containing protein (VCP): D2 mediates the major enzyme
activity, and D1 contributes to the heat-induced activity. *J. Biol.
Chem***.** 278, 3648-3655, 2003.

27\. Wang, Q., Song, C., Yang, X., and Li, C.-C.H. D1 ring is stable and
nucleotide-independent while D2 ring undergoes major conformational
changes during the ATPase cycle of p97-VCP. *J. Biol. Chem*. 278,
32784-32793, 2003.

28\. Wang, Q., Song, C, and Li, C.-C.H. Molecular perspectives on
p97-VCP: progress in understanding its structure and diverse biological
functions. *J. Structural Biol.* 146, 44-57, 2004.

29\. Yang, Y., Li, C.-C.H., and Weissman, A.M. Regulating the p53 system
through ubiquitination. *Oncogene* 23, 2096-2106, 2004.

30\. Wang, C., Song, C., Irizary, L., Zhang, X. and Li, C.-C.H.:
Multifunctional roles of the conserved Arg residues in the second region
of homology of p97/valosin-containing protein. *J. Biol. Chem*., in
press, 2005.

[Manuscripts Submitted]{.underline}:

1.  Song, C., Wang, Q. and Li, C.-C.H.: The D1 domain of p97-VCP in a
    hexameric structure is necessary and sufficient for suppressing
    protein aggregation in an ATPase-independent manner. *J. Biol.
    Chem*.

2\. Yang, H-S., Matthews, C.P., Clair, T., Wang, Q., Baker, A.R., Li,
C-C., Tan, T-H., and Colburn, N.H. *Molec. Cell Biol.*

[Manuscripts in Preparation]{.underline}:

1\. Dai, R., Song, C., McCoy, E., Pickart, C., and Li, C.-C.H.
Polyubiquitin-binding activity of p97-VCP.

2\. Song, C., Dai, R., Wang, Q., Kimonis, V.E., Watts, G.D.J., and Li,
C.-C.H**.** VCP mutations cause the loss of binding to polyubiquitinated
proteins and the blockage of ubiquitin-proteasome-mediated degradation
in hereditary inclusion body myopathy.

3\. Song, C., Lockett, S. Cho, E., Wang, Q. Colburn, N. and Li, C.-C.H.:
VCP passively transports within the cell and its N- and C-terminal
regions regulate the nucleocytoplasmic shuttling.