**UNITED STATES ENVIRONMENTAL PROTECTION
AGENCY**![](media/image1.png){width="0.9361111111111111in"
height="0.9444444444444444in"}

WASHINGTON, D.C. 20460

OFFICE OF

PREVENTION, PESTICIDES, AND

TOXIC SUBSTANCES

March 1, 2006

**MEMORANDUM**

SUBJECT: Transmittal of Revised Meeting Minutes of the FIFRA Scientific
Advisory Panel Meeting Held December 6-8, 2005 on Plant-Incorporated
Protectants Based on Virus Coat Protein Genes: Science Issues Associated
with the Proposed Rule

TO: Clifford J. Gabriel, Ph.D.

Director

> Office of Science Coordination and Policy

FROM: Paul I. Lewis, Ph.D.

Designated Federal Official

FIFRA Scientific Advisory Panel

Office of Science Coordination and Policy

Joseph E. Bailey

Designated Federal Official

> FIFRA Scientific Advisory Panel
>
> Office of Science Coordination and Policy

Attached, please find revised meeting minutes of the FIFRA Scientific
Advisory Panel open meeting held in Arlington, Virginia on December 6-8,
2005. This report addresses a set of scientific issues being considered
by the Environmental Protection Agency pertaining to Plant-Incorporated
Protectants Based on Virus Coat Protein Genes: Science Issues Associated
with the Proposed Rule.

Subsequent to issuance of the final minutes, one of the Panelists from
this meeting, Dr. Shou-Wei Ding, noted an error and provided a
clarification. The minutes have been revised as follows:

Page 12, sentence reading:

If designed for post-translational gene silencing (PTGS), this
restriction need not apply.

has been changed to:

If designed for post-transcriptional gene silencing (PTGS), this
restriction need not apply.

Page 13, section title reading:

Post-Translational Gene Silencing

has been changed to:

Post-Transcriptional Gene Silencing

Sentence reading:

Post-translational gene silencing (PTGS) is a highly desirable
transgenic resistance strategy for virus resistance because 1) it is
based on a natural plant defense mechanism against viruses themselves,
2) transgenes can easily be designed to produce only RNA, not protein,
and 3) PTGS gives stronger resistance than protein methods.

has been changed to:

PTGS is a highly desirable transgenic resistance strategy for virus
resistance because 1) it is based on a natural plant defense mechanism
against viruses themselves, 2) transgenes can easily be designed to
produce only RNA, not protein, and 3) PTGS gives stronger resistance
than protein methods.

Sentence reading:

Two types of PTGS-inducing transgenes can be shown to express no
protein: 1) transgene insertions, and 2) insertions of transcribed
inverted repeat (IR) constructs.

has been changed to:

Two types of PTGS-inducing transgenes can be shown to express no
protein: 1) transgene insertions that cannot be translated into
proteins, and 2) insertions of transcribed inverted repeat (IR)
constructs.

Page 26, sentence reading:

If the sequence was designed for post-translational gene silencing
(PTGS), this restriction does not apply.

has been changed to:

If the sequence was designed for PTGS, this restriction does not apply.

Attachment

cc:

Susan Hazen

Margaret Schneider

Amy Farrell

Jim Jones

Anne Lindsay

Margie Fehrenbach

Janet Andersen

Debbie Edwards

Steven Bradbury

William Diamond

Arnold Layne

Tina Levine

Lois Rossi

Frank Sanders

Randolph Perfetti

William Jordan

Douglas Parsons

Enesta Jones

Vanessa Vu (SAB)

Tom McClintock

Elizabeth Milewski

Anne Fairbrother

Melissa Kramer

Rebecca Edlestein

Tessa Milofsky

OPP Docket

FIFRA Scientific Advisory Panel Members

Stephen M. Roberts, Ph.D. (Chair of the FIFRA SAP)

John Bucher, Ph.D.

Janice E. Chambers, Ph.D.

H. Christopher Frey, Ph.D.

Stuart Handwerger, M.D.

Steven G. Heeringa, Ph.D.

Gary Isom, Ph.D.

Kenneth M. Portier, Ph.D.

FQPA Science Review Board Members

Judith Bender, Ph.D.

Judith Brown, Ph.D.

George Cobb, Ph.D.

Shou Wei Ding, Ph.D.

Bryce W. Falk, Ph.D.

Steven Gendel, Ph.D.

Jonathan Gressel, Ph.D.

Simon P. Hogan, Ph.D.

Roger Hull, Ph.D., D.Sc.

Alexander Karasev, Ph.D.

Steven A. Lommel, Ph.D.

Diana Pilson, Ph.D.

Lars K. Poulsen, Ph.D., M.D.

Geoffrey I. Scott, Ph.D.