> Number range CHAPTERUnited States Prevention, Pesticides
> EPA739-R-05-002

Environmental Protection and Toxic Substances September 2005

Agency (7508C)![](media/image1.wmf){width="1.4194444444444445in"
height="0.4986111111111111in"}

> **Reregistration Eligibility Decision For Triethylene Glycol**

**UNITED STATES ENVIRONMENTAL PROTECTION AGENCY**

WASHINGTON, D.C. 20460

OFFICE OF

PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES

**[CERTIFIED MAIL]{.underline}**

Dear Registrant:

This is to inform you that the Environmental Protection Agency (EPA) has
completed its review of the available data on the antimicrobial
triethylene glycol. The Reregistration Eligibility Decision (RED) was
approved in the form of a decision memorandum which summarized the
regulatory decision for triethylene glycol on September 30, 2003.

Based on the Agency's review, the Reregistration Eligibility Decision
(RED) and risk management decision with its associated human health and
environmental risk assessments are now being published. A Notice of
Availability will be published in the *Federal Register* announcing the
publication of the RED.

The RED and supporting documents for triethylene glycol will be
available to the public in EPA's Pesticide Docket **OPP-2005-0250** at:
<http://www.epa.gov/edockets>.

Please note that the attached RED document pertains only to triethylene
glycol and presents the Agency's conclusions on the dietary, drinking
water, occupational and ecological risks posed by exposure to
triethylene glycol alone. This document also contains product-specific
data that the Agency intends to require in Data Call-Ins (DCIs). Note
that DCIs, with all pertinent instructions, will be sent to registrants
at a later date. Currently, there are no generic data requirements. For
product-specific DCIs, the first set of required responses will be due
90 days from the receipt of the DCI letter. The second set of required
responses will be due eight months from the receipt of the DCI letter.

As part of the RED, the Agency has determined that triethylene glycol is
eligible for reregistration. Sections IV and V of this RED document
describe product-specific data requirements.

If you have questions on this document or the label changes relevant to
this reregistration decision, please contact the Chemical Review
Manager, Heather Garvie, at (703) 308-0034. For questions about product
reregistration and/or the Product DCI that accompanies this document,
please contact Marshall Swindell at (703) 308-6341.

Sincerely,

> Frank T. Sanders

Director, Antimicrobials Division

**REREGISTRATION ELIGIBILITY**

**DECISION**

for

Triethylene Glycol

List C

CASE 3146

Approved By:

> Frank T. Sanders
>
> Director, Antimicrobials Division

September 26, 2005

Number range CHAPTER**TABLE OF CONTENTS**

Triethylene Glycol Reregistration
Team..................................................................\...i

Glossary of Terms and Abbreviations
.....................................................................ii

Executive
Summary...........................................................................................1

I.
Introduction..................................................................................................3

II\. Chemical
Overview........................................................................................5

A. Regulatory
History...............................................................................5

B. Chemical
Identification..........................................................................5

C. Use
Profile.........................................................................................6

III\. Summary of Triethylene Glycol
Assessment...........................................................8

> A. Human Health
> Assessment............................................................\...\...\...\....8
>
> 1\. Toxicity of
> TEG........................................................................\...8
>
> 2\. FQPA Safety
> Factor....................................................................\...9
>
> 3\. Population Adjusted Dose (PAD)
> ......................................................9
>
> 4\. Dietary and Residential
> Exposure......................................................9
>
> 5\. Aggregate
> Exposure.....................................................................10
>
> 6\. Occupational
> Exposure.................................................................10
>
> 7\. Human Incident
> Data...................................................................10
>
> B. Environmental
> Assessment.....................................................................10
>
> 1\. Environmental Fate and
> Transport.....................................................10
>
> 2\. Ecological
> Risk..........................................................................11
>
> a\. Toxicity (Hazard)
> Assessment.............................................\....11
>
> b\. Risk to Listed
> Species..........................................................12

IV\. Risk Management, Reregistration and Tolerance Reassessment
Decision.......................13 A. Determination of Reregistration
Eligibility..................................................13

B. Comments and
Responses......................................................................13

C. Regulatory
Position..............................................................................13

> 1\. Food Quality Protection Act
> Findings................................................13
>
> a\. \"Risk Cup\"
> Determination.....................................................13
>
> b\. Determination of Safety to U.S.
> Population.................................14
>
> c\. Determination of Safety to Infants and
> Children........................\....14
>
> d\. Endocrine Disruptor
> Effects...................................................14
>
> e\. Cumulative
> Risks............................................................\....15
>
> 2\. Tolerance
> Summary.....................................................................15
>
> a\. Codex
> Harmonization..........................................................16
>
> D. Regulatory
> Rationale...........................................................................16
>
> 1\. Listed Species
> Considerations...........................\...\...\...\...\...\...\...\...\...\...\...\...\...16
>
> a\. The Endangered Species
> Act..................................................16
>
> b\. General Risk
> Mitigation.......................................................17

V. What Registrants Need to
Do........................................................................\.....18

> A. Manufacturing-Use
> Products............................................................\........19
>
> 1\. Additional Generic Data
> Requirements....................................... ...\.....19
>
> B. End-Use
> Products...........................................................................\...\...19
>
> 1\. Additional Product-Specific and Efficacy Data
> Requirements...............\...\...19

VI\.
Appendices.............................................................................................\....20

A. Table of Use Patterns Eligible for
Reregistration............................................21

> B. Table of Generic Data Requirements and Studies Used to Make the
>
> Reregistration
> Decision...................................................
> .......................42
>
> C. Technical Support
> Documents..................................................................49
>
> D. Bibliography
> Citations...........................................................................50
>
> E. Generic Data
> Call-In..............................................................................54
>
> F. Product Specific Data
> Call-In...................................................................55
>
> G. Batching of End-Use
> Products..................................................................56
>
> H. List of All Registrants Sent the Data
> Call-In.................................................59
>
> I. List of Available
> Forms..........................................................................60

**Triethylene Glycol Reregistration Team**

[Health Effects Risk Assessment]{.underline}

Michelle Centra

Tim McMahon

Najm Shamim

Timothy Leighton

Jonathan Chen

[Environmental Fate and Ecological Risk Assessment]{.underline}

Kathryn Montague

Najm Shamim

[Use and Usage Analysis]{.underline}

Heather Garvie

[Registration Support]{.underline}

Marshall Swindell

[Risk Management]{.underline}

Heather Garvie

Ben Chambliss

**GLOSSARY OF TERMS AND ABBREVIATIONS**

AE Acid Equivalent

a.i. Active Ingredient

AGDCI Agricultural Data Call-In

ai Active Ingredient

aPAD Acute Population Adjusted Dose

AR Anticipated Residue

ARC Anticipated Residue Contribution

BCF Bioconcentration Factor

CAS Chemical Abstracts Service

CI Cation

CNS Central Nervous System

cPAD Chronic Population Adjusted Dose

CSF Confidential Statement of Formula

CFR Code of Federal Regulations

CSFII USDA Continuing Surveys for Food Intake by Individuals

DCI Data Call-In

DEEM Dietary Exposure Evaluation Model

DFR Dislodgeable Foliar Residue

DRES Dietary Risk Evaluation System

DWEL Drinking Water Equivalent Level (DWEL) The DWEL represents a medium
specific (i.e., drinking water) lifetime exposure at which adverse,
noncarcinogenic health effects are not anticipated to occur.

DWLOC Drinking Water Level of Comparison.

EC Emulsifiable Concentrate Formulation

EEC Estimated Environmental Concentration. The estimated pesticide
concentration in an environment, such as a terrestrial ecosystem.

EP End-Use Product

EPA U.S. Environmental Protection Agency

FAO Food and Agriculture Organization

FDA Food and Drug Administration

FIFRA Federal Insecticide, Fungicide, and Rodenticide Act

FFDCA Federal Food, Drug, and Cosmetic Act

FQPA Food Quality Protection Act

FOB Functional Observation Battery

G Granular Formulation

GENEEC Tier I Surface Water Computer Model

GLC Gas Liquid Chromatography

GLN Guideline Number

GM Geometric Mean

GRAS Generally Recognized as Safe as Designated by FDA

HA Health Advisory (HA). The HA values are used as informal guidance to
municipalities and other organizations when emergency spills or
contamination situations occur.

HAFT Highest Average Field Trial

HDT Highest Dose Tested

IR Index Reservoir

LC~50~ Median Lethal Concentration. A statistically derived
concentration of a substance that can be expected to cause death in 50%
of test animals. It is usually expressed as the weight of substance per
weight or volume of water, air or feed, e.g., mg/l, mg/kg or ppm.

LD~50~ Median Lethal Dose. A statistically derived single dose that can
be expected to cause death in 50% of the test animals when administered
by the route indicated (oral, dermal, inhalation). It is expressed as a
weight of substance per unit weight of animal, e.g., mg/kg.

LEL Lowest Effect Level

LOC Level of Concern

LOD Limit of Detection

LOAEL Lowest Observed Adverse Effect Level

MATC Maximum Acceptable Toxicant Concentration

MCLG Maximum Contaminant Level Goal (MCLG) The MCLG is used by the
Agency to regulate contaminants in drinking water under the Safe
Drinking Water Act.

mg/kg/day Milligram Per Kilogram Per Day

mg/L Milligrams Per Liter

MOE Margin of Exposure

MP Manufacturing-Use Product

MPI Maximum Permissible Intake

MRID Master Record Identification (number). EPA\'s system of recording
and tracking studies submitted.

NA Not Applicable

N/A Not Applicable

NAWQA USGS National Water Quality Assessment

NOEC No Observable Effect Concentration

NOEL No Observed Effect Level

NOAEL No Observed Adverse Effect Level

NPDES National Pollutant Discharge Elimination System

NR Not Required

OP Organophosphate

OPP EPA Office of Pesticide Programs

OPPTS EPA Office of Prevention, Pesticides and Toxic Substances

Pa pascal, the pressure exerted by a force of one newton acting on an
area of one square meter.

PAD Population Adjusted Dose

PADI Provisional Acceptable Daily Intake

PAG Pesticide Assessment Guideline

PAM Pesticide Analytical Method

PCA Percent Crop Area

PDP USDA Pesticide Data Program

PHED Pesticide Handler\'s Exposure Data

PHI Preharvest Interval

ppb Parts Per Billion

PPE Personal Protective Equipment

ppm Parts Per Million

PRN Pesticide Registration Notice

PRZM/

EXAMS Tier II Surface Water Computer Model

Q~1~\* The Carcinogenic Potential of a Compound, Quantified by the
EPA\'s Cancer Risk Model

RAC Raw Agriculture Commodity

RBC Red Blood Cell

RED Reregistration Eligibility Decision

REI Restricted Entry Interval

RfD Reference Dose

RQ Risk Quotient

RS Registration Standard

RUP Restricted Use Pesticide

SAP Science Advisory Panel

SCI-GROW Tier I Ground Water Computer Model

SF Safety Factor

SLC Single Layer Clothing

SLN Special Local Need (Registrations Under Section 24(c) of FIFRA)

TC Toxic Concentration. The concentration at which a substance produces
a toxic effect.

TD Toxic Dose. The dose at which a substance produces a toxic effect.

TEP Typical End‑Use Product

TGAI Technical Grade Active Ingredient

TLC Thin Layer Chromatography

TMRC Theoretical Maximum Residue Contribution

torr A unit of pressure needed to support a column of mercury 1 mm high
under standard conditions.

TRR Total Radioactive Residue

UF Uncertainty Factor

g/g Micrograms Per Gram

g/L Micrograms Per Liter

USDA United States Department of Agriculture

USGS United States Geological Survey

UV Ultraviolet

WHO World Health Organization

WP Wettable Powder

WPS Worker Protection Standard

**EXECUTIVE SUMMARY**

The Environmental Protection Agency (hereafter referred to as EPA or the
Agency) has completed its human health and environmental review for
triethylene glycol and is issuing its risk management decision. The
Agency has decided that triethylene glycol is eligible for
reregistration. This Reregistration Eligibility Decision (RED) addresses
the use of triethylene glycol as a bacteriostat (against odor-causing
bacteria) for air sanitization and deodorization. In combination with
other active ingredients, it is used as a fungicide, virucide and
miticide for disinfection of hard, non-porous surfaces and as an
insecticide (against lice) by direct application to caged birds and to
the cage. For these uses, triethylene glycol is formulated primarily as
a pressurized liquid. This document also addresses the exposures from
the use of this pesticide as an inert ingredient. As an inert
ingredient, triethylene glycol facilitates delivery of formulated
pesticide chemical products that are used as herbicides, fungicides,
insecticides, growth regulators and attractants on a wide variety of
agricultural commodities. This RED reassesses the exemption from the
requirement for a tolerance for these uses. This tolerance exemption is
listed in 40 CFR 180.920 (69 FR 23124, Apr. 28, 2004).

In addition to the above, triethylene glycol is approved by the Food and
Drug Administration (FDA) as a preservative for food packaging adhesives
as listed in 21 CFR 175.105. Currently, however, there are no EPA
registered products for this use. Triethylene glycol also has an
indirect food additive regulation \[21 CFR 177.1200 (4/1/04)\] for its
use as a plasticizer in cellophane. This use is regulated by the Food
and Drug Administration (FDA).

**[Overall Risk Summary]{.underline}**

**Hazard Profile/Human Health Risk**

Based on a review of the available toxicology data, the Agency has
concluded that triethylene glycol is of very low toxicity by the oral,
dermal, and inhalation routes of exposure. The toxicology database is
adequate to characterize the hazard of triethylene glycol, and no data
gaps have been identified. There are no indications of special
sensitivity of infants or children resulting from exposure to
triethylene glycol. Therefore, the FQPA Safety Factor has been removed
(i.e., reduced to 1X) for triethylene glycol. The Agency has not
identified toxicological endpoints of concern for the active and the
inert uses of triethylene glycol. Therefore, a quantitative human health
risk assessment was not conducted for this RED document. The Agency has
no risk concerns for triethylene glycol with respect to human exposure.

**Environmental Risk**

The Agency has relied on open literature data that characterizes the
fate properties of triethylene glycol. The results of these studies
indicate that triethylene glycol is miscible in water, mobile in soils
and stable to abiotic degradation hydrolysis and soil and aquatic
photolysis. Biodegradation is expected to proceed rapidly in surface
waters.

Ecological effects data were previously waived due to the use of
triethylene glycol as an indoor microbiocide, its high volatility, and
known low toxicity (it is a preferred solvent for aquatic organism
toxicity tests). Data obtained from published studies provide additional
confirmation of the low toxicity of the compound to fish and aquatic
invertebrates. The Agency has no risk concerns for triethylene glycol
with respect to non-target organisms. The Agency expects no effects to
listed species or critical habitat and therefore makes a \"No Effect\"
determination for TEG.

**Regulatory Decision**

The Agency has completed its review and has determined that the data are
sufficient to support reregistration of all supported products
containing triethylene glycol.

**Summary of Mitigation Measures**

The Agency has determined that triethylene glycol is eligible for
reregistration. Since no risks of concern were identified, no specific
mitigation measures are needed for triethylene glycol.

**Data Requirements**

No additional confirmatory data is required to complete the
reregistration of triethylene glycol. However, product specific data is
required for all products containing triethylene glycol as described in
Section V of this document.

**I. INTRODUCTION**

The Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) was
amended in 1988 to accelerate the reregistration of products with active
ingredients registered prior to November 1, 1984 and amended again by
the Pesticide Registration Improvement Act of 2003 to set time frames
for the issuance of Reregistration Eligibility Decisions. The amended
Act calls for the development and submission of data to support the
reregistration of an active ingredient, as well as a review of all
submitted data by the Agency. Reregistration involves a thorough review
of the scientific database underlying a pesticide=s registration. The
purpose of the Agency=s review is to reassess the potential hazards
arising from the currently registered uses of the pesticide; to
determine the need for additional data on health and environmental
effects; and to determine whether the pesticide meets the Ano
unreasonable adverse effects@ criteria of FIFRA.

On August 3, 1996, the Food Quality Protection Act of 1996 (FQPA) was
signed into law. This Act amends FIFRA to require a tolerance
reassessment. The Agency has decided that, for those chemicals that have
tolerances and are undergoing reregistration, the tolerance reassessment
will be initiated through this reregistration process. The Act also
requires that by 2006, EPA must review all tolerances in effect on the
day before the date of the enactment of the FQPA. FQPA also amends the
Federal Food, Drug, and Cosmetic Act (FFDCA) to require a safety finding
in the tolerance reassessment based on factors including consideration
of cumulative effects of chemicals with a common mechanism of toxicity.
This document presents the Agency=s human health and ecological review
and the Reregistration Eligibility Decision for triethylene glycol.

Triethylene glycol is used as a bacteriostat (against odor-causing
bacteria) for air sanitization and deodorization. In combination with
other active ingredients, it is used as a fungicide, virucide and
miticide for disinfection of hard, non-pourous surfaces and as an
insecticide (against lice) by direct application to caged birds and bird
cages. This document also addresses the exposures and risks from the use
of this pesticide as an inert ingredient. As an inert ingredient,
triethylene glycol facilitates delivery of formulated pesticide chemical
products that are used as herbicides, fungicides, insecticides, growth
regulators and attractants on a wide variety of agricultural
commodities.

The Agency has concluded that the FQPA Safety Factor for triethylene
glycol should be removed (equivalent to 1X) because there is no pre- or
post-natal evidence of increased susceptibility for infants and children
following exposure to triethylene glycol.

The review summarized in this document concern only potential exposures
from the use of the active ingredient triethylene glycol and its use as
an inert ingredient. The Food Quality Protection Act (FQPA) requires
that the Agency consider available information concerning the cumulative
effects of a particular pesticide's residues and other substances that
have a common mechanism of toxicity. The reason for consideration of
other substances is due to the possibility that low-level exposures to
multiple chemical substances that cause a common toxic effect by a
common toxic mechanism could lead to the same adverse health effect that
would occur at a higher level of exposure to any of the substances
individually. Unlike other pesticides for which EPA has followed a
cumulative risk approach based on a common mechanism of toxicity, EPA
has not made a common mechanism of toxicity finding for triethylene
glycol and any other substances. Triethylene glycol does not appear to
produce a toxic metabolite produced by other substances. For the
purposes of this action, therefore, EPA has not assumed that triethylene
glycol has a common mechanism of toxicity with other substances. For
information regarding EPA's efforts to determine which chemicals have a
common mechanism of toxicity and to evaluate the cumulative effects of
such chemicals, see the policy statements released by the EPA's Office
of Pesticide Programs concerning common mechanism determinations and
procedures for cumulating effects from substances found to have a common
mechanism on EPA's website at
<http://www.epa.gov/pesticides/cumulative.>

This document presents the Agency's decision regarding the
reregistration eligibility of the registered uses of triethylene glycol.
In an effort to simplify the RED, the information presented herein is
summarized from more detailed information which can be found in the
technical supporting documents for triethylene glycol referenced in this
RED. Related documents are available in the Public Docket at
<http://www.epa.gov/edocket>.

This document consists of six sections. Section I is the introduction.
Section II provides a chemical overview, a profile of the use and usage
of triethylene glycol, and its regulatory history. Section III gives an
overview of the revised human health and environmental assessments based
on the data available to the Agency. Section IV presents the
reregistration eligibility and risk management decisions. Section V
summarizes procedures for the product-specific data call-in (PDCI).
Finally, the Appendices contain all use patterns eligible for
reregistration, bibliographic information, generic data requirements and
studies used to make the reregistration decision, related documents and
how to access them, and Data Call-In (DCI) information.

**II. CHEMICAL OVEVIEW**

**A. Regulatory History**

Triethylene glycol was first registered in 1947 for use in hospitals as
an air disinfectant. At one point, there were approximately 105
pesticide chemical companies having active triethylene glycol
registrations. Many of these registrations were canceled over the years
and more recently, the majority of the remaining producers of
triethylene glycol formulated pesticide products are being represented
by a consortium called the CSPA (Consumer Specialty Products
Association) Glycols Joint Venture. The member companies currently
represented by this consortium are: Amrep, Inc., Chase Products Co.,
Medo Industries, Inc., S.C. Johnson & Son, Waterbury Companies, Inc.,
Speer Products, Inc. and Quest Chemical Corporation.

**B. Chemical Identification**

**Triethylene Glycol:**

> \$ Common Name: Triethylene Glycol
>
> \$ Chemical Name: Triethylene Glycol
>
> \$ Chemical family: None
>
> \$ Case number: 3146
>
> \$ CAS registry number: 112-27-6
>
> \$ OPP chemical code: 083501
>
> \$ Empirical formula: C~6~H~14~O~4~
>
> \$ Molecular weight: 150.20 g/mol
>
> \$ Trade and other names: TEG
>
> \$ Manufacturers: CSPA Glycols Joint Venture companies (S.C. Johnson &
> Son, Inc., Waterbury Companies, Inc, Amrep, Inc., Speer Products,
> Inc., Quest Chemical Corporation, Medo Industries, Inc.
>
> \$ Specific Gravity: 1.1274
>
> \$ Solubility: Highly miscible in water
>
> Soluble in alcohol, benzene, toluene, sparingly
>
> soluble in ether and insoluble in petroleum ether
>
> \$ Boiling Point: 285 ^o^ C, ( at 760 mm Hg) 165 ^o^ C at 14 mm Hg.
>
> \$ Melting Point: - 5 ^o^ C (- 7 ^o^ C)^1^
>
> \$ Vapor Pressure: \< 0.01 mm Hg at 20 ^o^ C ( 0.00132 mm Hg at 25 ^o^
> C)^1^
>
> \$ Structure: OH-CH~2~-CH~2~-O-CH~2~-CH~2~-O-CH~2~-CH~2~-OH

**C. Use Profile**

The following is information on the currently registered uses of
triethylene glycol products and an overview of use sites and application
methods. A detailed table of the uses of triethylene glycol eligible for
reregistration is contained in Appendix A.

**Type of Pesticide:** Bacteriostat

**Summary of Use Sites:**

**[Indoor Non-Food:]{.underline}** Triethylene glycol is used on the
following use sites: air treatment (eating establishments, hospital,
commercial, institutional, household, bathroom, transportational
facilities); medical premises and equipment, commercial, institutional
and industrial premises and equipment; laundry equipment; hard
non-porous surface treatments (bathroom facilities); automobiles; air
conditioning filters; bird (caged) animal treatment; pet bird cages;
environmental inanimate hard surfaces; garbage containers/storage

**Target Pests:** Odor-causing bacteria

**Inert Uses:** As an inert ingredient, triethylene glycol facilitates
delivery of formulated pesticide chemical products that are used as
herbicides, fungicides, insecticides, growth regulators and attractants
on various commodities.

**Formulation Types:** Pressurized liquid

**Method and Rates of Application**

**[Equipment:]{.underline}** A wall mounted dispensing unit may be
needed, depending on the type of application. Otherwise, the sanitizer
is sprayed manually.

**[Method and Rate:]{.underline}** For a wall mounted unit, the number
of times the product is dispensed depends on the size of the room and
should be used in accordance with the label directions.

> If the product is dispensed from a metered dose aerosol can or from a
> hand held unit, as the amount dispensed will depend on the valve size
> utilized.
>
> For an air sanitizer in a continuous action aerosol can, a one second
> spray is used for a 9 2 x 9 x 7 room.
>
> Typically, an air sanitizer that is used manually is pointed toward
> the center of the room (12 x 12 x 9) and sprayed for ten seconds.

**Use Classification:** General use.

**III. SUMMARY OF TRIETHYLENE GLYCOL ASSESSMENT**

**A. Human Health Assessment**

**1. Toxicity of TEG**

A brief overview of the toxicity of triethylene glycol is presented
below. Further details on the toxicity of triethylene glycol can be
found in the supporting documentation for this RED. The Antimicrobials
Division Toxicology Endpoint Selection Committee (ADTC) memorandum, the
toxicology chapter for the RED and other supporting documentation are
available on the Agency's website in the EPA Docket at
[http://www.epa.gov/edockets.](http://www/epa.gov/dockets.)

The toxicological database for triethylene glycol is currently comprised
of published and unpublished studies either submitted to the Agency or
obtained directly from the open literature. Although the available
studies do not meet the requirements of the Agency=s OPPTS harmonized
test guidelines published in 1998, it was determined that these studies
contain useful information that is adequate for hazard characterization
of triethylene glycol. These acceptable non-guideline studies include
acute, subchronic, chronic, developmental, and reproductive toxicity,
carcinogenicity, mutagenicity, metabolism/pharmacokinetics and dermal
absorption studies. Therefore, the Agency has determined that the
toxicological database is complete and sufficient for reregistration.

Major features of the toxicology profile are presented below.
Triethylene glycol is shown to be of low toxicity, with the exception of
a dermal irritation study which was Toxicity Category III due to slight
irritation.

**Table 1. Acute Toxicity of Triethylene Glycol** **Technical**

  ------------------------- ------------ ------------------------- ------------
  **Guideline No./ Study    **MRID**     **Results**               **Toxicity
  Type**                                                           Category**

  870.1100 Acute Oral       42814404 &   LD~50~ = 15,000 --22,000  IV
  Toxicity                  open         mg/kg                     
                            literature                             

  870.1200 Acute Dermal     \_\_         Waived                    \_\_
  Toxicity                                                         

  870.1300 Acute Inhalation OTS:         LC~50~ \> 5.2 mg/L        IV
  Toxicity                  527779-2                               

  870.2400 Acute Eye        42814404     Mild eye irritation       IV
  Irritation                                                       

  870.2500 Acute Dermal     42814404     Slight irritation         III
  Irritation                                                       

  870.2600 Skin             Open         Non-sensitizer            ---
  Sensitization             literature                             
  ------------------------- ------------ ------------------------- ------------

**[General Toxicity Observations]{.underline}**

Upon reviewing the available toxicity information, the Agency has
concluded that there are no endpoints of concern for oral, dermal, or
inhalation exposure to triethylene glycol. This conclusion is based on
the results of toxicity testing of triethylene glycol in which dose
levels near or above testing limits (as established in the OPPTS 870
series harmonized test guidelines) were employed in experimental animal
studies and no significant toxicity observed.

**[Carcinogenicity Classification]{.underline}**

A review of the available data has shown triethylene glycol to be
negative for carcinogenicity in studies conducted up to the testing
limit doses established by the Agency; therefore, no carcinogenic
analysis is required.

**[Mutagenicity Potential]{.underline}**

Triethylene glycol was tested for mutagenic or genotoxic potential and
found to be negative in a battery of studies: a bacterial gene mutation
assay using Salmonella typhimurium, and in vitro Chinese hamster ovary
(CHO) mutation assay, an in vitro Chinese hamster ovary (CHO)
chromosomal aberration assay and an in vitro sister chromatid exchange
assay.

**2. FQPA Safety Factor**

The FQPA Safety Factor (as required by the Food Quality Protection Act
of 1996) is intended to provide an additional 10-fold safety factor
(10X), to protect for special sensitivity in infants and children to
specific pesticide residues in food, drinking water, or residential
exposures, or to compensate for an incomplete database. The FQPA Safety
Factor has been removed (i.e., reduced to 1X) for triethylene glycol
because there is no pre- or post-natal evidence for increased
susceptibility following exposure. Further, the Agency has concluded
that there are no endpoints of concern for oral, dermal, or inhalation
exposure to triethylene glycol based on the low toxicity observed in
studies conducted near or above testing limit doses as established in
the OPPTS 870 series harmonized test guidelines. Therefore, a
quantitative risk assessment was not conducted for triethylene glycol.

**3. Population Adjusted Dose (PAD)**

Dietary risk is characterized in terms of the Population Adjusted Dose
(PAD), which reflects the reference dose (RfD), either acute or chronic,
that has been adjusted to account for the FQPA Safety Factor (SF). This
calculation is performed for each population subgroup. A risk estimate
that is less than 100% of the acute or chronic PAD is not of concern.
Since toxicological endpoints for risk assessment were not identified
based on the available data, RfD's and PAD's have not been calculated
for triethylene glycol.

**4. Dietary and Residential Exposure**

Dietary exposure (food and drinking water) could potentially occur from
the use of triethylene glycol as a preservative in food packaging
adhesives and from its use as an inert ingredient in agricultural
pesticide formulations. Residential exposure could also potentially
occur as a result of the use of triethylene glycol in and around the
home as a sanitizer, disinfectant and bird treatment. However, risk
estimates have not been calculated for potential exposures to
triethylene glycol on food, in drinking water, or as a result of use in
residential settings because there are no toxicological endpoints of
concern according to a review of the available toxicity data.

**5. Aggregate Exposure**

The Food Quality Protection Act amendments to the Federal Food, Drug,
and Cosmetic Act (FFDCA, Section 408(b)(2)(A)(ii)) require "that there
is a reasonable certainty that no harm will result from aggregate
exposure to pesticide chemical residue, including all anticipated
dietary exposures and other exposures for which there are reliable
information." Aggregate exposure will typically include exposures from
food, drinking water, residential uses of a pesticide and other
non-occupational sources of exposure.

Since toxicological endpoints for risk assessment were not identified
based on the available data, an aggregate risk assessment was not
conducted for triethylene glycol.

**6. Occupational Exposure**

The occupational exposure assessment for triethylene glycol addresses
potential exposures and risks to humans who may be exposed in
Aoccupational settings". An occupational and risk assessment is required
for an active ingredient if: 1) certain toxicological criteria are
triggered; and 2) there is potential exposure to handlers (mixers,
loaders, applicators, etc.) during use or to persons entering treated
sites after application is complete. For triethylene glycol, there is
potential for exposure, however, there are no toxicological endpoints of
concern, according to a review of the available toxicity.

**7. Human Incident Data**

In evaluating incidents to humans, the Agency reviewed reports from the
1993-1996 National Poison Control Centers (PCC), the Agency's Office of
Pesticide Program's Incident Data System (IDS), the California
Department of Pesticide Regulation, and the National Pesticide
Telecommunications Network (NPTN). Although there are incidences that
have been reported associated with TEG in the searched database, there
is no one reported incident involving TEG as a single chemical exposure.
Either no effects or minor effects are involved in these reported
incidences. The other ingredients in combination with TEG may be the
reasons for the symptoms that have been reported.

**B. Environmental Assessment**

A summary of the Agency's environmental review is presented below. For
detailed discussions of all aspects of the environmental review, see the
Product Chemistry, Environmental Fate and Toxicology chapters available
on the Agency's website in the EPA Docket at:
[http://www/epa.gov/edockets.](http://www/epa.gov/dockets.)

**1. Environmental Fate and Transport**

Triethylene glycol is an aliphatic trihydroxy chemical and does not
contain any hydrolyzable hydrogen. For this reason, the Agency granted a
waiver from the aquatic hydrolysis study. For the reregistration
process, however, the Agency has reviewed available open literature data
and conducted the environmental fate assessment of triethylene glycol.

Based on a review of the open literature, triethylene glycol is miscible
in water, mobile in soils and stable to abiotic hydrolytic degradation
as well as soil and aquatic photolysis. A number of River Dye-away tests
(complete mineralization between 7 and 11 days) have shown that
triethylene glycol degrades in soils in days (primary degradation) to
weeks (complete mineralization). In addition, sludge innoculum studies
indicate that triethylene glycol undergoes ready biodegradation. The use
of sludge innoculum data as a surrogate for terrestrial soil metabolism
is subject to considerable uncertainty because sludge innoculums tend to
be acclimated to the introduction of organic substances more so than
soils and the biomass on a per volume basis tends to be greater.

**2. Ecological Risk**

a.  **Toxicity (Hazard) Assessment**

As a result of the Phase IV review of triethylene glycol for
reregistration under FIFRA, ecological effects data requirements were
waived due to its intended use as an indoor microbiocide, its high
volatility, and known low toxicity (it is a preferred solvent for
aquatic organism toxicity tests). Data obtained from published studies
provide additional confirmation of the low toxicity of the compound to
fish and aquatic invertebrates (Table 2). As mentioned earlier in this
document, no toxicological endpoints were selected for risk assessment
based on the available mammalian database.

**Table 2. Ecotoxicity of Triethylene Glycol**

  --------------- -------------- -------------- -------------- ---------------
  **Species**     **Percent      **Test Type**  **Toxicity**   **Reference**
                  Active                                       
                  Ingredient**                                 

  Mysid           99.9           96-hour static LC50 = 11,000  MRID #40228401
  (*Mysidopsis                   acute          ppm            (Mayer, 1986)
  bahia)*                                                      

  Sheepshead      99.9           96-hour static LC50 = 48,000  MRID #40228401
  minnow                         acute          ppm            (Mayer, 1986)
  (*Cyprinodon                                                 
  variegatus*)                                                 

  Bluegill        unknown        96 hour static LC50 \> 10,000 Verschuren,
  sunfish                        acute          ppm            1983
  (*Lepomis                                                    
  macrochirus*)                                                

  *Menidia        unknown        96 hour static LC50 \> 10,000 Verschuren,
  beryllina*                                    ppm            1983

  Fathead minnow  unknown        96 hour        LC 50 59,900 - Geiger et al.,
  (*Pimephales                   flow-through   77,400 ppm     1988
  promelas*)                                                   
  --------------- -------------- -------------- -------------- ---------------

Adverse effects to nontarget organisms are not anticipated from the
indoor use of triethylene glycol due to the low likelihood of exposure.
The very low toxicity of the compound to aquatic organisms, as indicated
by the high LC50 values in the table above, further supports the
unlikelihood of adverse effects to fish and aquatic invertebrates.

b.  **Risk to Listed Species**

Due to the low likelihood of exposure and low toxicity of triethylene
glycol, the Agency expects no effects to listed species or critical
habitat and therefore makes a \"No Effect\" determination for this
chemical.

**IV. RISK MANAGEMENT, REREGISTRATION AND TOLERANCE REASSESSMENT
DECISION**

**A. Determination of Reregistration Eligibility**

Section 4(g)(2)(A) of FIFRA calls for the Agency to determine, after
submission of relevant data concerning an active ingredient, whether
products containing the active ingredient are eligible for
reregistration. The Agency has previously identified and required the
submission of the generic (*i.e.* active ingredient-specific) data to
support reregistration of products containing triethylene glycol. The
Agency has completed its review of these generic data, and has
determined that the data are sufficient to support reregistration of all
supported products containing triethylene glycol.

The Agency has completed its assessment of the dietary, drinking water,
residential, ecological and occupational risks associated with the use
of pesticide products containing the active ingredient triethylene
glycol. Based on a review of these data, the Agency has sufficient
information on the human health and ecological effects of triethylene
glycol to make a decision as part of the tolerance reassessment process
under FFDCA and reregistration under FIFRA, as amended by FQPA. The
Agency has determined that triethylene glycol containing products are
eligible for reregistration. Appendix A summarizes the uses of
triethylene glycol that are eligible for reregistration. Appendix B
identifies the generic data requirements that the Agency reviewed as
part of its determination of reregistration eligibility of triethylene
glycol, and lists the submitted studies that the Agency found
acceptable.

**B. Comments and Responses**

Supporting documents for triethylene glycol were not issued for public
comment per the Agency's public participation process because no
toxicological endpoints were identified and, as such, a quantitative
risk assessment was not conducted. To ensure that opportunity is
presented to the public to comment on the risk management decisions and
supporting documents for triethylene glycol, the Agency will implement a
public comment period on this RED document.

**C. Regulatory Position**

**1. Food Quality Protection Act Findings**

> **a.** **ARisk Cup@ Determination**

Upon reviewing the available toxicity information, the Agency has
concluded that there are no endpoints of concern for oral, dermal, or
inhalation exposure to triethylene glycol. This conclusion is based on
the results of toxicity testing of triethylene glycol in which dose
levels near or above testing limits (as established in the OPPTS 870
series harmonized test guidelines) were employed in experimental animal
studies and no significant toxicity observed. The Agency has concluded
that the exemption from the requirement for a tolerance is appropriate
and is considered reassessed as required by FQPA. An aggregate
assessment was not conducted for exposures through food, drinking water
and residential exposure since toxicological endpoints for risk
assessment were not identified based on the available data. In reaching
this determination, EPA has considered the available information on the
special sensitivity of infants and children, as well as aggregate
exposure.

**b. Determination of Safety to U.S. Population**

As part of the FQPA tolerance reassessment process, EPA has concluded
that there are no endpoints of concern for oral, dermal, or inhalation
exposure to triethylene glycol. This conclusion is based on the results
of toxicity testing of triethylene glycol in which dose levels near or
above testing limits (as established in the OPPTS 870 series harmonized
test guidelines) were employed in experimental animal studies and no
significant toxicity observed. The Agency has determined that the
established exemption from the requirement for a tolerance for
triethylene glycol meets the safety standards under the FQPA amendments
to section 408(b)(2)(D) of the FFDCA, and that there is a reasonable
certainty no harm will result to the general population or any subgroup
from the use of triethylene glycol. In reaching this conclusion, the
Agency has considered all available information on the toxicity, use
practices and exposure scenarios, and the environmental behavior of
triethylene glycol.

Because no toxicological endpoints were identified for triethylene
glycol, the Agency has determined that exposure to it does not result in
human health effects of concern. Therefore a quantitative risk
assessment was not necessary for this pesticide.

**c. Determination of Safety to Infants and Children**

EPA has determined that the established exemption from a requirement for
a tolerance for triethylene glycol, meet the safety standards under the
FQPA amendments to section 408(b)(2)(C) of the FFDCA, that there is a
reasonable certainty of no harm for infants and children. The safety
determination for infants and children considers factors of the
toxicity, use practices, and environmental behavior noted above for the
general population, but also takes into account the possibility of
increased dietary exposure due to the specific consumption patterns of
infants and children, as well as the possibility of increased
susceptibility to the toxic effects of triethylene glycol residues in
this population subgroup.

In determining whether or not infants and children are particularly
susceptible to toxic effects from triethylene glycol residues, the
Agency considered the completeness of the database for developmental and
reproductive effects, the nature of the effects observed, and other
information. The FQPA Safety Factor has been removed (i.e., reduced to
1X) for triethylene glycol because there is no pre- or post-natal
evidence for increased susceptibility following exposure.

**d. Endocrine Disruptor Effects**

EPA is required under the FFDCA, as amended by FQPA, to develop a
screening program to determine whether certain substances (including all
pesticide active and other ingredients) "may have an effect in humans
that is similar to an effect produced by a naturally occurring estrogen,
or other endocrine effects as the Administrator may designate."
Following recommendations of its Endocrine Disruptor Screening and
Testing Advisory Committee (EDSTAC), EPA determined that there was a
scientific basis for including, as part of the program, the androgen and
thyroid hormone systems, in addition to the estrogen hormone system. EPA
also adopted EDSTAC's recommendation that EPA include evaluations of
potential effects in wildlife. For pesticides, EPA will use FIFRA and,
to the extent that effects in wildlife may help determine whether a
substance may have an effect in humans, FFDCA authority to require the
wildlife evaluations. As the science develops and resources allow,
screening of additional hormone systems may be added to the Endocrine
Disruptor Screening Program (EDSP).

When the appropriate screening and/or testing protocols being considered
under the EDSP have been developed, triethylene glycol may be subject to
additional screening and/or testing to better characterize effects
related to endocrine disruption.

**e. Cumulative Risks**

Any risks summarized in this document are those that result only from
the use of triethylene glycol. The Food Quality Protection Act (FQPA)
requires that the Agency consider "available information" concerning the
cumulative effects of a particular pesticide's residues and "other
substances that have a common mechanism of toxicity." The reason for
consideration of other substances is due to the possibility that
low-level exposures to multiple chemical substances that cause a common
toxic effect by a common toxic mechanism could lead to the same adverse
health effect as would a higher level of exposure to any of the
substances individually. Unlike other pesticides for which EPA has
followed a cumulative risk approach based on a common mechanism of
toxicity, EPA has not made a common mechanism of toxicity finding for
triethylene glycol. For information regarding EPA's efforts to determine
which chemicals have a common mechanism of toxicity and to evaluate the
cumulative effects of such chemicals, see the policy statements released
by EPA's Office of Pesticide Programs concerning common mechanism
determinations and procedures for cumulating effects from substances
found to have a common mechanism on EPA's website at
<http://www.epa.gov/pesticides/cumulative/>.

**2. Tolerance Summary**

The tolerance exemption for residues of triethylene glycol *per se* is
established under 40 CFR 180.920 (69 FR 23124, Apr.28, 2004).

***Tolerance Exemptions***

The following tolerance exemption for triethylene glycol is listed in 40
CFR 180.920 (7/1/04):

Triethylene glycol is exempted from the requirement of a tolerance when
used as an inert (or occasionally active) ingredient in pesticide
formulations applied to growing crops only as a deactivator.

In addition to the above, triethylene glycol is approved by the Food and
Drug

Administration as a preservative for food packaging adhesives as listed
in 21 CFR 175.105.

Triethylene glycol also has an indirect food additive regulation (21 CFR
177.1200) for its use as a plasticizer in cellophane. However, this use
is regulated solely by the Food and Drug Administration (FDA).

**a. Codex Harmonization**

Currently there are no Codex MRLs established for triethylene glycol.

**D. Regulatory Rationale**

The Agency has determined triethylene glycol is eligible for
reregistration. Based on the available data, the Agency has concluded
that triethylene glycol exhibits low toxicity and exposures to
triethylene glycol used as both an active or inert ingredient do not
present risks of concern to the Agency. Therefore, no mitigation
measures are necessary at this time.

**1. Listed Species Considerations**

**a. The Endangered Species Act**

[]{.mark}

Section 7 of the Endangered Species Act, 16 U.S.C. Section 1536(a)(2),
requires all federal agencies to consult with the National Marine
Fisheries Service (NMFS) for marine and anadromous listed species, or
the United States Fish and Wildlife Services (FWS) for listed wildlife
and freshwater organisms, if they are proposing an \"action\" that may
affect listed species or their designated habitat. Each federal agency
is required under the Act to insure that any action they authorize,
fund, or carry out is not likely to jeopardize the continued existence
of a listed species or result in the destruction or adverse modification
of designated critical habitat. To jeopardize the continued existence of
a listed species means \"to engage in an action that reasonably would be
expected, directly or indirectly, to reduce appreciably the likelihood
of both the survival and recovery of a listed species in the wild by
reducing the reproduction, numbers, or distribution of the species.\" 50
C.F.R. § 402.02.

To facilitate compliance with the requirements of the Endangered Species
Act subsection (a)(2) the Environmental Protection Agency, Office of
Pesticide Programs has established procedures to evaluate whether a
proposed registration action may directly or indirectly reduce
appreciably the likelihood of both the survival and recovery of a listed
species in the wild by reducing the reproduction, numbers, or
distribution of any listed species (U.S. EPA 2004). After the Agency's
screening-level risk assessment is performed, if any of the Agency's
Listed Species LOC Criteria are exceeded for either direct or indirect
effects, a determination is made to identify if any listed or
[candidate]{.mark} species may co-occur in the area of the proposed
pesticide use. If determined that listed or candidate species may be
present in the proposed use areas, further biological assessment is
undertaken. The extent to which listed species may be at risk then
determines the need for the development of a more comprehensive
consultation package as required by the Endangered Species Act.

For certain use categories, the Agency assumes there will be minimal
environmental exposure, and only a minimal toxicity data set is required
(Overview of the Ecological Risk Assessment Process in the Office of
Pesticide Programs U.S. Environmental Protection Agency - Endangered and
Threatened Species Effects Determinations, 1/23/04, Appendix A, Section
IIB, pg.81). Chemicals in these categories therefore do not undergo a
full screening-level risk assessment, and are considered to fall under a
"no effect" determination. Due to the low likelihood of exposure and low
toxicity of triethylene glycol, the Agency expects no effects to listed
species or critical habitat and therefore makes a \"No Effect\"
determination for this chemical.

**b. General Risk Mitigation**

Triethylene glycol end-use products (EPs) may also contain other
registered pesticides. Although the Agency is not proposing any
mitigation measures for products containing triethylene glycol specific
to federally listed species, the Agency needs to address potential risks
from other end-use products. Therefore, the Agency requires that users
adopt all listed species risk mitigation measures for all active
ingredients in the product. If a product contains multiple active
ingredients with conflicting listed species risk mitigation measures,
the more stringent measure(s) should be adopted.

**V. WHAT REGISTRANTS NEED TO DO**

The Agency has determined that triethylene glycol is eligible for
reregistration. No additional generic data are required at this time to
support this decision.

[For end use products containing the active ingredient triethylene
glycol]{.underline}, the registrant needs to submit the following items
for each product.

**Within 90 days from the receipt of the product-specific data call-in
(PDCI)**:

1\. completed response forms to the PDCI (i.e., PDCI response form and
requirements status and registrant's response form); and

2\. submit any time extension or waiver requests with a full written
justification.

**Within eight months from the receipt of the PDCI:**

1\. two copies of the confidential statement of formula (EPA Form
8570-4);

2\. a completed original application for reregistration (EPA Form
8570-1). Indicate on the form that it is an "application for
reregistration";

3\. a completed form certifying compliance with data compensation
requirements (EPA Form 8570-34);

4\. if applicable, a completed form certifying compliance with cost
share offer requirements (EPA Form 8570-32); and

5\. the product-specific data responding to the PDCI.

Please contact Marshall Swindell at (703) 308-6341 with questions
regarding product reregistration and/or the PDCI. All materials
submitted in response to the PDCI should be addressed as follows:

By US mail: By express or courier service:

Document Processing Desk (PDCI/PRB) Document Processing Desk (PDCI/PRB)

Marshall Swindell Marshall Swindell

US EPA (7510C) Office of Pesticide Programs (7510C)

1200 Pennsylvania Ave., NW Room 266A, Crystal Mall 2

Washington, DC 20460 1801 South Bell Street

Arlington, VA 22202

**A. Manufacturing-Use Products**

There are no currently registered triethylene glycol manufacturing-use
products.

**1. Additional Generic Data Requirements**

The generic data base supporting the reregistration of triethylene
glycol for the above eligible uses has been reviewed and determined to
be substantially complete. Therefore at this time, there are no generic
data requirements.

**B. End-Use Products**

**1. Additional Product-Specific and Efficacy Data Requirements**

Section 4(g)(2)(B) of FIFRA calls for the Agency to obtain any needed
product-specific data regarding the pesticide after a determination of
eligibility has been made. Registrants must review previous data
submissions to ensure that they meet current EPA acceptance criteria and
if not, commit to conduct new studies. If a registrant believes that
previously submitted data meet current testing standards, then the study
MRID numbers should be cited according to the instructions in the
Requirement Status and Registrants Response Form provided for each
product.

The Agency considers the terms \"sanitizer\" and \"sanitization\" to be
public health claims, regardless of the use site or whether the specific
organisms for which the product is efficacious against are identified or
not. This policy was reiterated in the proposed Part 152/156
Antimicrobial Registration Requirements, 64 FR 50672-50730, September
17, 1999. Upon finalization of this proposed rulemaking, efficacy data
will be required to support the continued use of the term \"air
sanitizer\" on the product label.

Until the proposed Product Performance Guidelines for proposed Part
152/15 are finalized, testing requirements are being deferred for
products of this type. Currently, efficacy requirements are satisfied by
the chemical formula statement showing appropriate glycol content. For
products containing at least 5% glycols (triethylene, dipropylene,
and/or propylene glycols), quantitative chemical determinations must be
performed, using an air sampling device, to show the concentration of
glycol vapor achieved with the product in an enclosed experimental room
or chamber when used as directed.

A product-specific data call-in, outlining specific data requirements,
will be issued shortly. In the interim, no additional public health
claims can be made unless supported by the appropriate efficacy data.

**VI. APPENDICES**

Number range CHAPTER**Appendix A: Use Patterns Eligible for
Reregistration**

Use Categories:

\(1\) Agricultural premises and equipment

\(2\) Food handling/ storage establishments premises and equipment

\(3\) Commercial, institutional and industrial premises and equipment

\(4\) Residential and public access premises

\(5\) Medical premises and equipment

\(6\) Human water systems

\(7\) Materials preservatives

\(8\) Industrial processes and water systems

\(9\) Antifouling coatings

\(10\) Wood preservatives

\(11\) Swimming pools

\(12\) Aquatic areas

+------------------+--------+--------------+------------+-------------+
| **Number range   | **F    | *            | **No. of   | **Use       |
| CHAPTERUse       | ormula | *Application | Appl       | Li          |
| Site**           | tion** | Rate         | ications** | mitations** |
|                  |        | (Range)**    |            |             |
+------------------+--------+--------------+------------+-------------+
| **1.             |        |              |            |             |
| Agricultural     |        |              |            |             |
| Premises and     |        |              |            |             |
| Equipment [- no  |        |              |            |             |
| registered uses  |        |              |            |             |
| for this         |        |              |            |             |
| p                |        |              |            |             |
| attern]{.mark}** |        |              |            |             |
+------------------+--------+--------------+------------+-------------+
| **2. Food        |        |              |            |             |
| Handling/Storage |        |              |            |             |
| Establishments   |        |              |            |             |
| Premises and     |        |              |            |             |
| Equipment**      |        |              |            |             |
+------------------+--------+--------------+------------+-------------+
| Air Treatment    | 1\.    | 1\. 7 ounce  | 1\.        | [1. do not  |
| (Eating          | 1080   | product      | i          | use in      |
| Establishments)  | 7-43 - | contains     | nformation | nurseries   |
|                  | press  | 3400         | not given  | or rooms    |
|                  | urized | controlled   | on label   | where       |
|                  | li     | sprays that  |            | infants,    |
|                  | quid - | will last    |            | ill or aged |
|                  | aut    | for 30 days  |            | patients    |
|                  | omatic | when used on |            | are         |
|                  | dis    | a 24 hour    |            | confined;   |
|                  | penser | basis or 60  |            | food, food  |
|                  |        | days if used |            | contact     |
|                  |        | 12 hours per |            | surfaces    |
|                  |        | day when set |            | and         |
|                  |        | to dispense  |            | utensils    |
|                  |        | every 15     |            | should be   |
|                  |        | minutes      |            | protected   |
|                  |        | (room size   |            | from        |
|                  |        | not          |            | exposure to |
|                  |        | specified)   |            | the spray   |
|                  |        |              |            | or rinsed   |
|                  |        |              |            | with        |
|                  |        |              |            | potable     |
|                  |        |              |            | water       |
|                  |        |              |            | before      |
|                  |        |              |            | use]{.mark} |
+------------------+--------+--------------+------------+-------------+
|                  | 2\.    | 2\. spray    | 2\. spray  | 2\. food,   |
|                  | 10     | the room     | several    | food        |
|                  | 807-37 | until a      | times per  | contact     |
|                  | &      | light fog    | day        | surfaces    |
|                  | 1080   | forms -      |            | and         |
|                  | 7-24 - | spray 6 to 8 |            | utensils    |
|                  | press  | seconds in   |            | should be   |
|                  | urized | an average   |            | protected   |
|                  | li     | room (10 X   |            | from        |
|                  | quid - | 10)          |            | exposure to |
|                  | manual |              |            | the spray   |
|                  | spray  |              |            | or rinsed   |
|                  |        |              |            | with        |
|                  |        |              |            | potable     |
|                  |        |              |            | water       |
|                  |        |              |            | before use  |
+------------------+--------+--------------+------------+-------------+
| **3. Commercial, |        |              |            |             |
| Institutional    |        |              |            |             |
| and Industrial   |        |              |            |             |
| Premises and     |        |              |            |             |
| Equipment**      |        |              |            |             |
+------------------+--------+--------------+------------+-------------+
| Commercial       | [44    | [spray       | []{.mark}i | [wash hands |
| Premises &       | 446-20 | surface      | nformation | before      |
| equipment        | -]     | until        | not given  | eating,     |
|                  | {.mark | completely   | on label   | drinking,   |
|                  | }press | wet and      |            | chewing     |
|                  | urized | allow to     |            | gum, using  |
|                  | liquid | remain wet   |            | tobacco, or |
|                  | [-     | for 10       |            | using the   |
|                  | manual | minutes; for |            | toi         |
|                  | s      | air          |            | let]{.mark} |
|                  | pray]{ | sanitization |            |             |
|                  | .mark} | spray for    |            |             |
|                  |        | three        |            |             |
|                  |        | sec          |            |             |
|                  |        | onds]{.mark} |            |             |
+------------------+--------+--------------+------------+-------------+
| Shower Room      | [44    | [spray       | [i         | [wash hands |
| Premises         | 446-20 | surface      | nformation | before      |
|                  | -press | until        | not given  | eating,     |
|                  | urized | completely   | on         | drinking,   |
|                  | li     | wet and      | lab        | chewing     |
|                  | quid - | allow to     | el]{.mark} | gum, using  |
|                  | manual | remain wet   |            | tobacco, or |
|                  | s      | for 10       |            | using the   |
|                  | pray]{ | minutes; for |            | toi         |
|                  | .mark} | air          |            | let]{.mark} |
|                  |        | sanitization |            |             |
|                  |        | spray for    |            |             |
|                  |        | three        |            |             |
|                  |        | sec          |            |             |
|                  |        | onds]{.mark} |            |             |
+------------------+--------+--------------+------------+-------------+
| Air Treatment    | 1\.    | 1\. metered  | 1\.        | [1. do not  |
| (Unspecified)    | 944    | valve        | i          | contaminate |
|                  | 4-136- | actuates     | nformation | water, food |
|                  | press  | every        | not given  | or feed by  |
|                  | urized | fifteen      | on label   | storage or  |
|                  | li     | minutes - 7  |            | dispo       |
|                  | quid - | ounce        |            | sal]{.mark} |
|                  | aut    | product      |            |             |
|                  | omatic | treats a     |            |             |
|                  | dis    | room up to   |            |             |
|                  | penser | 30 X 20 X 10 |            |             |
+------------------+--------+--------------+------------+-------------+
|                  | [2.    | [2. spray    | [2.        | [2. avoid   |
|                  | 482    | upward in    | i          | contact     |
|                  | 2-293- | center of    | nformation | with        |
|                  | press  | room for 10  | not given  | f           |
|                  | urized | seconds in   | on         | ood]{.mark} |
|                  | li     | average room | lab        | and food    |
|                  | quid - | of 12 X 12 X | el]{.mark} | utensils    |
|                  | manual | 9)]{.mark}   |            |             |
|                  | s      |              |            |             |
|                  | pray]{ |              |            |             |
|                  | .mark} |              |            |             |
+------------------+--------+--------------+------------+-------------+
| Laundry          | [44    | [spray       | []{.mark}i | [wash hands |
| Equipment        | 446-20 | surface      | nformation | before      |
|                  | -press | until        | not given  | eating,     |
| []{.mark}        | urized | completely   | on label   | drinking,   |
|                  | li     | wet and      |            | chewing     |
| []{.mark}        | quid - | allow to     |            | gum, using  |
|                  | manual | remain wet   |            | tobacco, or |
| []{.mark}        | s      | for 10       |            | using the   |
|                  | pray]{ | min          |            | toi         |
| []{.mark}        | .mark} | utes]{.mark} |            | let]{.mark} |
+------------------+--------+--------------+------------+-------------+
| [Air Treatment   | [1.    | [1. 7 ounces | 1\.        | [1. do not  |
| (Locker          | 10     | of product   | i          | use in      |
| Room)]{.mark}    | 807-43 | contains     | nformation | nurseries   |
|                  | -press | 3400         | not given  | or rooms    |
| []{.mark}        | urized | controlled   | on label   | where       |
|                  | li     | sprays that  |            | infants,    |
| []{.mark}        | quid - | will last    |            | ill or aged |
|                  | aut    | for 30 days  |            | patients    |
| []{.mark}        | omatic | when used on |            | are         |
|                  | dispe  | a 24 hour    |            | confined;   |
| []{.mark}        | nser]{ | basis or 60  |            | food, food  |
|                  | .mark} | days if used |            | contact     |
| []{.mark}        |        | 12 hours per |            | surfaces    |
|                  |        | day when set |            | and         |
| []{.mark}        |        | to dispense  |            | utensils    |
|                  |        | every 15     |            | should be   |
| []{.mark}        |        | minutes      |            | protected   |
|                  |        | (room size   |            | from        |
| []{.mark}        |        | not          |            | exposure to |
|                  |        | specif       |            | the spray   |
| []{.mark}        |        | ied)]{.mark} |            | or rinsed   |
|                  |        |              |            | with        |
| []{.mark}        |        |              |            | potable     |
|                  |        |              |            | water       |
| []{.mark}        |        |              |            | before      |
|                  |        |              |            | use]{.mark} |
| []{.mark}        |        |              |            |             |
|                  |        |              |            |             |
| []{.mark}        |        |              |            |             |
+------------------+--------+--------------+------------+-------------+
|                  | [2.    | 2\. 6.2      | 2\.        | 2\. do not  |
|                  | 94     | ounces       | sprayed at | contaminate |
|                  | 44-19- | treats 6,000 | intervals  | water, food |
|                  | press  | cubic feet   |            | or feed     |
|                  | urized | of closed    |            |             |
|                  | li     | air space.   |            |             |
|                  | quid - |              |            |             |
|                  | aut    |              |            |             |
|                  | omatic |              |            |             |
|                  | interm |              |            |             |
|                  | ittent |              |            |             |
|                  | a      |              |            |             |
|                  | erosol |              |            |             |
|                  | dispe  |              |            |             |
|                  | nser]{ |              |            |             |
|                  | .mark} |              |            |             |
+------------------+--------+--------------+------------+-------------+
|                  | [3.    | 3\. spray    | 3\. spray  | 3\. food,   |
|                  | 10     | the room     | several    | food        |
|                  | 807-37 | until a      | times per  | contact     |
|                  | &      | light fog    | day        | surfaces    |
|                  | 10     | forms -      |            | and         |
|                  | 807-24 | spray 6 to 8 |            | utensils    |
|                  | -press | seconds in   |            | should be   |
|                  | urized | an average   |            | protected   |
|                  | li     | room (10 X   |            | from        |
|                  | quid - | 10)          |            | exposure to |
|                  | manual |              |            | the spray   |
|                  | s      |              |            | or rinsed   |
|                  | pray]{ |              |            | with        |
|                  | .mark} |              |            | potable     |
|                  |        |              |            | water       |
|                  | []{    |              |            | before use  |
|                  | .mark} |              |            |             |
+------------------+--------+--------------+------------+-------------+
| [Locker Room     | [44    | [spray       | i          | [wash hands |
| Premises]{.mark} | 446-20 | surface      | nformation | before      |
|                  | -press | until        | not given  | eating,     |
|                  | urized | completely   | on label   | drinking,   |
|                  | li     | wet and      |            | chewing     |
|                  | quid - | allow to     |            | gum, using  |
|                  | manual | remain wet   |            | tobacco, or |
|                  | s      | for 10       |            | using the   |
|                  | pray]{ | minutes or   |            | toi         |
|                  | .mark} | for air      |            | let]{.mark} |
|                  |        | sanitization |            |             |
|                  |        | spray for    |            |             |
|                  |        | three        |            |             |
|                  |        | sec          |            |             |
|                  |        | onds]{.mark} |            |             |
+------------------+--------+--------------+------------+-------------+
| [Air Treatment   | [1.    | 1\. 7 ounce  | 1\.        | [1. avoid   |
| (Instit          | 5      | product for  | product    | co          |
| utional)]{.mark} | 1838-1 | each 6,000   | sprayed at | ntamination |
|                  | -]{    | cubic feet   | intervals  | of          |
| []{.mark}        | .mark} | of closed    |            | f           |
|                  | ready  | air space    |            | ood]{.mark} |
| []{.mark}        | to use |              |            |             |
|                  | sol    |              |            |             |
| []{.mark}        | ution- |              |            |             |
|                  | aut    |              |            |             |
| []{.mark}        | omatic |              |            |             |
|                  | dis    |              |            |             |
| []{.mark}        | penser |              |            |             |
|                  | ope    |              |            |             |
| []{.mark}        | ration |              |            |             |
|                  |        |              |            |             |
| []{.mark}        |        |              |            |             |
|                  |        |              |            |             |
| []{.mark}        |        |              |            |             |
|                  |        |              |            |             |
| []{.mark}        |        |              |            |             |
+------------------+--------+--------------+------------+-------------+
|                  | [2.    | [2. fill     | [2. repeat | [2. avoid   |
|                  | 51     | average size | a          | co          |
|                  | 838-1- | room with    | pplication | ntamination |
|                  | press  | mist         | several    | of          |
|                  | urized | (a           | times      | f           |
|                  | li     | pproximately | dai        | ood]{.mark} |
|                  | quid - | 15           | ly]{.mark} |             |
|                  | for    | spr          |            |             |
|                  | manual | ays)]{.mark} |            |             |
|                  | opera  |              |            |             |
|                  | tion]{ |              |            |             |
|                  | .mark} |              |            |             |
+------------------+--------+--------------+------------+-------------+
|                  | [3.    | [3. spray    | [3. spray  | [3. food,   |
|                  | 10     | the room     | several    | food        |
|                  | 807-37 | until a      | times per  | contact     |
|                  | &      | light fog    | d          | surfaces    |
|                  | 108    | forms -      | ay]{.mark} | and         |
|                  | 07-24- | spray 6 to 8 |            | utensils    |
|                  | press  | seconds in   |            | should be   |
|                  | urized | an average   |            | protected   |
|                  | l      | room (10 X   |            | from        |
|                  | iquid- | 10)]{.mark}  |            | exposure to |
|                  | manual |              |            | the spray   |
|                  | s      |              |            | or rinsed   |
|                  | pray]{ |              |            | with        |
|                  | .mark} |              |            | potable     |
|                  |        |              |            | water       |
|                  |        |              |            | before      |
|                  |        |              |            | use]{.mark} |
+------------------+--------+--------------+------------+-------------+
|                  | [4.    | [4. spray    | [4.        | [4. avoid   |
|                  | 4822   | upward in    | i          | contact     |
|                  | -293-] | center       | nformation | with        |
|                  | {.mark | of]{.mark}   | not given  | f           |
|                  | }press | room for [10 | on         | ood]{.mark} |
|                  | urized | seconds in   | lab        | and food    |
|                  | liquid | average room | el]{.mark} | utensils    |
|                  | [-     | of 12 X 12 X |            |             |
|                  | manual | 9)]{.mark}   |            |             |
|                  | s      |              |            |             |
|                  | pray]{ |              |            |             |
|                  | .mark} |              |            |             |
+------------------+--------+--------------+------------+-------------+
|                  | [5.    | [5. one      | [          | [5. do not  |
|                  | 48     | second spray | 5.]{.mark} | position    |
|                  | 22-531 | for a 9.5 X  | i          | near heat   |
|                  | -press | 9 X 7        | nformation | or          |
|                  | urized | room]{.mark} | not given  | electrical  |
|                  | li     |              | on label   | sources; do |
|                  | quid - |              |            | not spray   |
|                  | wall   |              |            | directly    |
|                  | m      |              |            | onto        |
|                  | ounted |              |            | surfaces;   |
|                  | unit   |              |            | in case of  |
|                  | in     |              |            | contact     |
|                  | cont   |              |            | with        |
|                  | inuous |              |            | surfaces,   |
|                  | action |              |            | wipe        |
|                  | a      |              |            | immediately |
|                  | erosol |              |            | with damp   |
|                  | can]{  |              |            | clo         |
|                  | .mark} |              |            | th.]{.mark} |
+------------------+--------+--------------+------------+-------------+
| []{.mark}        | 6\.    | [6. spray    | 6\.        | 6\. [wash   |
|                  | 44     | for three    | i          | hands       |
|                  | 446-20 | sec          | nformation | before      |
|                  | -press | onds]{.mark} | not given  | eating,     |
|                  | urized |              | on label   | drinking,   |
|                  | li     |              |            | chew- ing   |
|                  | quid - |              |            | gum, using  |
|                  | manual |              |            | tobacco, or |
|                  | spray  |              |            | using the   |
|                  |        |              |            | toi         |
|                  |        |              |            | let]{.mark} |
+------------------+--------+--------------+------------+-------------+
|                  | [7.    | [7. using a  | [7.        | [7. do not  |
|                  | 4      | 120 μl valve | i          | position    |
|                  | 822-53 | with .22     | nformation | near heat   |
|                  | 1-wall | ounces of    | not given  | or          |
|                  | m      | prod         | on         | electrical  |
|                  | ounted | uct:]{.mark} | lab        | sources; do |
|                  | unit   |              | el]{.mark} | not spray   |
|                  | in     | [-1 time for |            | directly    |
|                  | m      | 2.5 X 2.5 X  |            | onto        |
|                  | etered | 7            |            | surfaces;   |
|                  | dose   | room]{.mark} |            | in case of  |
|                  | a      |              |            | contact     |
|                  | erosol | [-2 times    |            | with        |
|                  | can]{  | for 4 X 3 X  |            | surfaces,   |
|                  | .mark} | 7            |            | wipe        |
|                  | or     | room]{.mark} |            | immediately |
|                  | press  |              |            | with damp   |
|                  | urized | [-3 times    |            | clo         |
|                  | [li    | for 4.5 X 4  |            | th.]{.mark} |
|                  | quid - | X 7          |            |             |
|                  | hand   | room]{.mark} |            | []{.mark}   |
|                  | held   |              |            |             |
|                  | unit]{ | [-4 times    |            |             |
|                  | .mark} | for 5 X 5 X  |            |             |
|                  |        | 7            |            |             |
|                  |        | room]{.mark} |            |             |
|                  |        |              |            |             |
|                  |        | []{.mark}    |            |             |
|                  |        |              |            |             |
|                  |        | [using a 185 |            |             |
|                  |        | μl           |            |             |
|                  |        | va           |            |             |
|                  |        | lve-]{.mark} |            |             |
|                  |        |              |            |             |
|                  |        | [-1 time for |            |             |
|                  |        | 3 X 3 X 7    |            |             |
|                  |        | room]{.mark} |            |             |
|                  |        |              |            |             |
|                  |        | [-2 times    |            |             |
|                  |        | for 4.5 X 4  |            |             |
|                  |        | X 7          |            |             |
|                  |        | room]{.mark} |            |             |
|                  |        |              |            |             |
|                  |        | [-3 times    |            |             |
|                  |        | for a 5.5 X  |            |             |
|                  |        | 5 X 7        |            |             |
|                  |        | room]{.mark} |            |             |
|                  |        |              |            |             |
|                  |        | [4 times for |            |             |
|                  |        | a 6 X 6 X 7  |            |             |
|                  |        | room]{.mark} |            |             |
+------------------+--------+--------------+------------+-------------+
| []{.mark}        | [8.    | [8. 7 ounce  | [8.        | [8. do not  |
|                  | 10     | product      | i          | use in      |
| []{.mark}        | 807-43 | contains     | nformation | nurseries   |
|                  | -press | 3400         | not given  | or rooms    |
| []{.mark}        | urized | controlled   | on         | where       |
|                  | li     | sprays that  | lab        | infants,    |
| []{.mark}        | quid - | will last    | el]{.mark} | ill or aged |
|                  | aut    | for 30 days  |            | patients    |
| []{.mark}        | omatic | when used on |            | are         |
|                  | dispe  | a 24 hour    |            | confined;   |
| []{.mark}        | nser]{ | basis or 60  |            | food, food  |
|                  | .mark} | days if used |            | contact     |
| []{.mark}        |        | 12 hours per |            | surfaces    |
|                  |        | day when set |            | and         |
| []{.mark}        |        | to dispense  |            | utensils    |
|                  |        | every 15     |            | should be   |
| []{.mark}        |        | minutes      |            | protected   |
|                  |        | (room size   |            | from        |
|                  |        | not          |            | exposure to |
|                  |        | specif       |            | the spray   |
|                  |        | ied)]{.mark} |            | or rinsed   |
|                  |        |              |            | with        |
|                  |        |              |            | potable     |
|                  |        |              |            | water       |
|                  |        |              |            | before      |
|                  |        |              |            | use]{.mark} |
+------------------+--------+--------------+------------+-------------+
| [Air Treatment   | [1.    | [1. 7 ounce  | [1.        | [1. avoid   |
| (Com             | 51     | product for  | product    | co          |
| mercial)]{.mark} | 838-1- | each 6,000   | sprayed at | ntamination |
|                  | ready  | cubic feet   | interva    | of          |
| []{.mark}        | to use | of closed    | ls]{.mark} | f           |
|                  | solu   | air          |            | ood]{.mark} |
|                  | tion - | s            |            |             |
|                  | for    | pace]{.mark} |            |             |
|                  | aut    |              |            |             |
|                  | omatic |              |            |             |
|                  | dis    |              |            |             |
|                  | penser |              |            |             |
|                  | opera  |              |            |             |
|                  | tion]{ |              |            |             |
|                  | .mark} |              |            |             |
+------------------+--------+--------------+------------+-------------+
|                  | [2.    | [2. fill     | [2. repeat | [2. avoid   |
|                  | 5183   | average size | a          | co          |
|                  | 8-1-]{ | room with    | pplication | ntamination |
|                  | .mark} | mist         | several    | of          |
|                  | ready  | (a           | times      | f           |
|                  | to use | pproximately | dai        | ood]{.mark} |
|                  | so     | 15           | ly]{.mark} |             |
|                  | lution | spr          |            |             |
|                  | [- for | ays)]{.mark} |            |             |
|                  | manual |              |            |             |
|                  | opera  |              |            |             |
|                  | tion]{ |              |            |             |
|                  | .mark} |              |            |             |
+------------------+--------+--------------+------------+-------------+
|                  | [3.    | [3. 7 ounce  | [3.        | [3. do not  |
|                  | 10     | product      | i          | use in      |
|                  | 807-43 | contains     | nformation | nurseries   |
|                  | -]     | 3400         | not given  | or rooms    |
|                  | {.mark | controlled   | on         | where       |
|                  | }press | sprays that  | lab        | infants,    |
|                  | urized | will last    | el]{.mark} | ill or aged |
|                  | l      | for 30 days  |            | patients    |
|                  | iquid- | when used on |            | are         |
|                  | [aut   | a 24 hour    |            | confined;   |
|                  | omatic | basis or 60  |            | food, food  |
|                  | dispe  | days if used |            | contact     |
|                  | nser]{ | 12 hours per |            | surfaces    |
|                  | .mark} | day when set |            | and         |
|                  |        | to dispense  |            | utensils    |
|                  |        | every 15     |            | should be   |
|                  |        | minutes      |            | protected   |
|                  |        | (room size   |            | from        |
|                  |        | not          |            | exposure to |
|                  |        | specif       |            | the spray   |
|                  |        | ied)]{.mark} |            | or rinsed   |
|                  |        |              |            | with        |
|                  |        |              |            | potable     |
|                  |        |              |            | water       |
|                  |        |              |            | before      |
|                  |        |              |            | use]{.mark} |
+------------------+--------+--------------+------------+-------------+
|                  | [4.    | [4. spray    | [4. spray  | [4. food,   |
|                  | 10     | the room     | several    | food        |
|                  | 807-37 | until a      | times per  | contact     |
|                  | &      | light fog    | d          | surfaces    |
|                  | 10     | forms -      | ay]{.mark} | and         |
|                  | 807-24 | spray 6 to 8 |            | utensils    |
|                  | -press | seconds in   |            | should be   |
|                  | urized | an average   |            | protected   |
|                  | li     | room (10 X   |            | from        |
|                  | quid - | 10)]{.mark}  |            | exposure to |
|                  | manual |              |            | the spray   |
|                  | s      |              |            | or rinsed   |
|                  | pray]{ |              |            | with        |
|                  | .mark} |              |            | potable     |
|                  |        |              |            | water       |
|                  |        |              |            | before      |
|                  |        |              |            | use]{.mark} |
+------------------+--------+--------------+------------+-------------+
|                  | [5.    | [5. 6.2      | [5.        | [5. do not  |
|                  | 944    | ounces of    | sprayed at | contaminate |
|                  | 4-19 - | product      | interva    | water, food |
|                  | Press  | treats 6,000 | ls]{.mark} | or          |
|                  | urized | cubic feet   |            | f           |
|                  | li     | of closed    |            | eed]{.mark} |
|                  | quid - | air          |            |             |
|                  | aut    | sp           |            |             |
|                  | omatic | ace.]{.mark} |            |             |
|                  | interm |              |            |             |
|                  | ittent |              |            |             |
|                  | a      |              |            |             |
|                  | erosol |              |            |             |
|                  | dispe  |              |            |             |
|                  | nser]{ |              |            |             |
|                  | .mark} |              |            |             |
+------------------+--------+--------------+------------+-------------+
|                  | [6.    | [6. spray    | [6.        | [6. avoid   |
|                  | 4822   | upward in    | i          | contact     |
|                  | -293 - | center of    | nformation | with food   |
|                  | press  | room for 10  | not given  | and food    |
|                  | urized | seconds in   | on         | utens       |
|                  | li     | average room | lab        | ils]{.mark} |
|                  | quid - | of 12 X 12 X | el]{.mark} |             |
|                  | manual | 9)]{.mark}   |            |             |
|                  | s      |              |            |             |
|                  | pray]{ |              |            |             |
|                  | .mark} |              |            |             |
+------------------+--------+--------------+------------+-------------+
|                  | [7.    | [7. spray    | [7.        | [7. wash    |
|                  | 444    | for three    | i          | hands       |
|                  | 46-20- | sec          | nformation | before      |
|                  | press  | onds]{.mark} | not given  | eating,     |
|                  | urized |              | on         | drinking,   |
|                  | li     |              | lab        | chewing     |
|                  | quid - |              | el]{.mark} | gum, using  |
|                  | manual |              |            | tobacco, or |
|                  | s      |              |            | using the   |
|                  | pray]{ |              |            | toi         |
|                  | .mark} |              |            | let]{.mark} |
+------------------+--------+--------------+------------+-------------+
|                  | [8.    | 8\. spray    | 8\. repeat | 8\. spray   |
|                  | 5      | for one      | a          | away from   |
|                  | 1838-2 | second       | pplication | drapes,     |
|                  | -press | toward       | several    | walls,      |
|                  | urized | center of    | times      | plastic,    |
|                  | li     | average size | daily      | vinyl,      |
|                  | quid - | room (10 X   |            | painted or  |
|                  | aut    | 14 X 8)      |            | varnished   |
|                  | omatic |              |            | surfaces    |
|                  | dispe  |              |            |             |
|                  | nser]{ |              |            |             |
|                  | .mark} |              |            |             |
+------------------+--------+--------------+------------+-------------+
| [Air Treatment   | 1\.    | 1\. 7 ounces | 1\.        | [1. avoid   |
| (Transp          | 5      | of product   | product    | co          |
| Fac              | 1838-1 | for each     | sprayed at | ntamination |
| ilities)]{.mark} | -ready | 6,000 cubic  | intervals  | of          |
|                  | to use | feet of      |            | f           |
| []{.mark}        | solu   | closed air   |            | ood]{.mark} |
|                  | tion - | space        |            |             |
| []{.mark}        | for    |              |            |             |
|                  | aut    |              |            |             |
| []{.mark}        | omatic |              |            |             |
|                  | dis    |              |            |             |
| []{.mark}        | penser |              |            |             |
|                  |        |              |            |             |
| []{.mark}        |        |              |            |             |
|                  |        |              |            |             |
| []{.mark}        |        |              |            |             |
|                  |        |              |            |             |
| []{.mark}        |        |              |            |             |
|                  |        |              |            |             |
| []{.mark}        |        |              |            |             |
|                  |        |              |            |             |
| []{.mark}        |        |              |            |             |
|                  |        |              |            |             |
| []{.mark}        |        |              |            |             |
+------------------+--------+--------------+------------+-------------+
|                  | [2.    | [2. spray    | [2.        | [2. avoid   |
|                  | 48     | upward in    | i          | contact     |
|                  | 22-293 | center of    | nformation | with food   |
|                  | -press | room for 10  | not given  | and food    |
|                  | urized | seconds in   | on         | utens       |
|                  | li     | average room | lab        | ils]{.mark} |
|                  | quid - | of 12 X 12 X | el]{.mark} |             |
|                  | manual | 9]{.mark}    |            |             |
|                  | s      |              |            |             |
|                  | pray]{ |              |            |             |
|                  | .mark} |              |            |             |
+------------------+--------+--------------+------------+-------------+
|                  | [3.    | [3. spray    | [3. spray  | [3. food,   |
|                  | 10     | the room     | several    | food        |
|                  | 807-37 | until a      | times per  | contact     |
|                  | &      | light fog    | d          | surfaces    |
|                  | 10     | forms -      | ay]{.mark} | and         |
|                  | 807-24 | spray 6 to 8 |            | utensils    |
|                  | -press | seconds in   |            | should be   |
|                  | urized | an average   |            | protected   |
|                  | li     | room (10 X   |            | from        |
|                  | quid - | 10)]{.mark}  |            | exposure to |
|                  | manual |              |            | the spray   |
|                  | s      |              |            | or rinsed   |
|                  | pray]{ |              |            | with        |
|                  | .mark} |              |            | potable     |
|                  |        |              |            | water       |
|                  |        |              |            | before      |
|                  |        |              |            | use]{.mark} |
+------------------+--------+--------------+------------+-------------+
|                  | [4.    | [4. fill     | [4. repeat | [4. avoid   |
|                  | 51     | average size | a          | co          |
|                  | 838-1- | room with    | pplication | ntamination |
|                  | ready  | mist         | several    | of          |
|                  | to use | (a           | times      | f           |
|                  | solu   | pproximately | dai        | ood]{.mark} |
|                  | tion - | 15           | ly]{.mark} |             |
|                  | for    | spr          |            |             |
|                  | manual | ays)]{.mark} |            |             |
|                  | opera  |              |            |             |
|                  | tion]{ |              |            |             |
|                  | .mark} |              |            |             |
+------------------+--------+--------------+------------+-------------+
| [Air Treatment   | 1\.    | 1\. 7 ounces | [1.        | [1. avoid   |
| (Ind             | 51     | of product   | product    | co          |
| ustrial)]{.mark} | 838-1- | for each 6,  | sprayed at | ntamination |
|                  | ready  | 000 cubic    | interva    | of          |
| []{.mark}        | to use | feet of      | ls]{.mark} | f           |
|                  | solu   | closed air   |            | ood]{.mark} |
| []{.mark}        | tion - | space        |            |             |
|                  | aut    |              |            |             |
| []{.mark}        | omatic |              |            |             |
|                  | dis    |              |            |             |
| []{.mark}        | penser |              |            |             |
|                  |        |              |            |             |
| []{.mark}        |        |              |            |             |
|                  |        |              |            |             |
| []{.mark}        |        |              |            |             |
|                  |        |              |            |             |
| []{.mark}        |        |              |            |             |
|                  |        |              |            |             |
| []{.mark}        |        |              |            |             |
|                  |        |              |            |             |
| []{.mark}        |        |              |            |             |
|                  |        |              |            |             |
| []{.mark}        |        |              |            |             |
|                  |        |              |            |             |
| []{.mark}        |        |              |            |             |
|                  |        |              |            |             |
| []{.mark}        |        |              |            |             |
|                  |        |              |            |             |
| []{.mark}        |        |              |            |             |
|                  |        |              |            |             |
| []{.mark}        |        |              |            |             |
+------------------+--------+--------------+------------+-------------+
|                  | [2.    | [2. fill     | [2. repeat | [2. avoid   |
|                  | 5      | average size | a          | co          |
|                  | 1838-1 | room with    | pplication | ntamination |
|                  | -ready | mist         | several    | of          |
|                  | to use | (a           | times      | f           |
|                  | solu   | pproximately | dai        | ood]{.mark} |
|                  | tion - | 15           | ly]{.mark} |             |
|                  | for    | spr          |            |             |
|                  | manual | ays)]{.mark} |            |             |
|                  | opera  |              |            |             |
|                  | tion]{ |              |            |             |
|                  | .mark} |              |            |             |
+------------------+--------+--------------+------------+-------------+
|                  | 3\.    | [3. spray    | [3. spray  | [3. food,   |
|                  | 10     | the room     | several    | food        |
|                  | 807-37 | until a      | times per  | contact     |
|                  | &      | light fog    | d          | surfaces    |
|                  | 108    | forms -      | ay]{.mark} | and         |
|                  | 07-24- | spray 6 to 8 |            | utensils    |
|                  | press  | seconds in   |            | should be   |
|                  | urized | an average   |            | protected   |
|                  | li     | room (10 X   |            | from        |
|                  | quid - | 10)]{.mark}  |            | exposure to |
|                  | manual |              |            | the spray   |
|                  | spray  | []{.mark}    |            | or rinsed   |
|                  |        |              |            | with        |
|                  |        | []{.mark}    |            | potable     |
|                  |        |              |            | water       |
|                  |        |              |            | before      |
|                  |        |              |            | use]{.mark} |
+------------------+--------+--------------+------------+-------------+
|                  | [4.    | [4. 7 ounces | [4.        | [4. do not  |
|                  | 1080   | of product   | i          | use in      |
|                  | 7-43-] | contains     | nformation | nurseries   |
|                  | {.mark | 3400         | not given  | or rooms    |
|                  | }press | controlled   | on         | where       |
|                  | urized | sprays that  | lab        | infants,    |
|                  | li     | will last    | el]{.mark} | ill or aged |
|                  | quid - | for 30 days  |            | patients    |
|                  | aut    | when used on |            | are         |
|                  | omatic | a 24 hour    |            | confined;   |
|                  | dis    | basis or 60  |            | food, food  |
|                  | penser | days if used |            | contact     |
|                  |        | 12 hours per |            | surfaces    |
|                  |        | day when set |            | and         |
|                  |        | to dispense  |            | utensils    |
|                  |        | every 15     |            | should be   |
|                  |        | minutes      |            | protected   |
|                  |        | (room size   |            | from        |
|                  |        | not          |            | exposure to |
|                  |        | specif       |            | the spray   |
|                  |        | ied)]{.mark} |            | or rinsed   |
|                  |        |              |            | with        |
|                  |        |              |            | potable     |
|                  |        |              |            | water       |
|                  |        |              |            | before      |
|                  |        |              |            | use]{.mark} |
+------------------+--------+--------------+------------+-------------+
| **[4.            |        |              |            |             |
| Residential and  |        |              |            |             |
| Public Access    |        |              |            |             |
| Pr               |        |              |            |             |
| emises]{.mark}** |        |              |            |             |
+------------------+--------+--------------+------------+-------------+
| [Air Treatment   | [1.    | 1\. metered  | 1\.        | [1. do not  |
| (Unsp            | 9444-  | valve        | i          | contaminate |
| ecified)]{.mark} | 136-]{ | actuates     | nformation | water, food |
|                  | .mark} | every        | not given  | or feed by  |
|                  | press  | fifteen      | on label   | storage or  |
|                  | urized | minutes - 7  |            | dispo       |
|                  | li     | ounce        |            | sal]{.mark} |
|                  | quid - | product      |            |             |
|                  | aut    | treats a     |            |             |
|                  | omatic | room up to   |            |             |
|                  | dis    | 30 X 20 X 10 |            |             |
|                  | penser |              |            |             |
+------------------+--------+--------------+------------+-------------+
|                  | [2.    | [2. spray    | [2.        | [2. avoid   |
|                  | 482    | upward in    | i          | contact     |
|                  | 2-293- | center of    | nformation | with        |
|                  | press  | room for 10  | not given  | f           |
|                  | urized | seconds in   | on         | ood]{.mark} |
|                  | li     | average room | lab        | and food    |
|                  | quid - | of 12 X 12 X | el]{.mark} | utensils    |
|                  | manual | 9)]{.mark}   |            |             |
|                  | s      |              |            |             |
|                  | pray]{ |              |            |             |
|                  | .mark} |              |            |             |
+------------------+--------+--------------+------------+-------------+
| [Household       | [44446 | [spray       | [i         | [wash hands |
| (Premises &      | -20-]{ | surface      | nformation | before      |
| C                | .mark} | until        | not given  | eating,     |
| ontents)]{.mark} | press  | completely   | on         | drinking,   |
|                  | urized | wet and      | lab        | chewing     |
|                  | li     | allow to     | el]{.mark} | gum, using  |
|                  | quid - | remain wet   |            | tobacco, or |
|                  | manual | for 10       |            | using the   |
|                  | spray  | minutes or   |            | toi         |
|                  |        | for air      |            | let]{.mark} |
|                  |        | sanitization |            |             |
|                  |        | spray for    |            |             |
|                  |        | three        |            |             |
|                  |        | sec          |            |             |
|                  |        | onds]{.mark} |            |             |
+------------------+--------+--------------+------------+-------------+
| [Air treatments  | [48    | [using a 120 | [i         | [do not     |
| (commercial/ho   | 22-531 | μl valve     | nformation | position    |
| usehold)]{.mark} | -press | with .22     | not given  | near heat   |
|                  | urized | ounces of    | on         | or          |
| []{.mark}        | li     | prod         | lab        | electrical  |
|                  | quid - | uct:]{.mark} | el]{.mark} | sources; do |
| []{.mark}        | wall   |              |            | not spray   |
|                  | m      | [-1 time for |            | directly    |
|                  | ounted | 2.5 X 2.5 X  |            | onto        |
|                  | unit   | 7            |            | surfaces;   |
|                  | in     | room]{.mark} |            | in case of  |
|                  | m      |              |            | contact     |
|                  | etered | [-2 times    |            | with        |
|                  | dose   | for 4 X 3 X  |            | surfaces,   |
|                  | a      | 7            |            | wipe        |
|                  | erosol | room]{.mark} |            | immediately |
|                  | can or |              |            | with damp   |
|                  | hand   | [-3 times    |            | clo         |
|                  | held   | for 4.5 X 4  |            | th.]{.mark} |
|                  | unit]{ | X 7          |            |             |
|                  | .mark} | room]{.mark} |            |             |
|                  |        |              |            |             |
|                  | []{    | [-4 times    |            |             |
|                  | .mark} | for 5 X 5 X  |            |             |
|                  |        | 7            |            |             |
|                  | []{    | room]{.mark} |            |             |
|                  | .mark} |              |            |             |
|                  |        | []{.mark}    |            |             |
|                  |        |              |            |             |
|                  |        | [using a 185 |            |             |
|                  |        | μl           |            |             |
|                  |        | va           |            |             |
|                  |        | lve-]{.mark} |            |             |
|                  |        |              |            |             |
|                  |        | [-1 time for |            |             |
|                  |        | 3 X 3 X 7    |            |             |
|                  |        | room]{.mark} |            |             |
|                  |        |              |            |             |
|                  |        | [-2 times    |            |             |
|                  |        | for 4.5 X 4  |            |             |
|                  |        | X 7          |            |             |
|                  |        | room]{.mark} |            |             |
|                  |        |              |            |             |
|                  |        | [-3 times    |            |             |
|                  |        | for a 5.5 X  |            |             |
|                  |        | 5 X 7        |            |             |
|                  |        | room]{.mark} |            |             |
|                  |        |              |            |             |
|                  |        | [4 times for |            |             |
|                  |        | a 6 X 6 X 7  |            |             |
|                  |        | room]{.mark} |            |             |
+------------------+--------+--------------+------------+-------------+
| Laundry          | [44    | [spray       | i          | [wash hands |
| Equipment        | 446-20 | surface      | nformation | before      |
|                  | -press | until        | not given  | eating,     |
|                  | urized | completely   | on label   | drinking,   |
|                  | li     | wet and      |            | chewing     |
|                  | quid - | allow to     |            | gum, using  |
|                  | manual | remain wet   |            | tobacco, or |
|                  | s      | for 10       |            | using the   |
|                  | pray]{ | min          |            | to          |
|                  | .mark} | utes]{.mark} |            | ile]{.mark} |
+------------------+--------+--------------+------------+-------------+
| [Aut             | [44    | [spray into  | [i         | [shut off   |
| omobiles]{.mark} | 446-20 | air          | nformation | air         |
|                  | -press | conditioning | not given  | conditioner |
|                  | urized | system and   | on         | after       |
|                  | li     | spray for    | lab        | applying    |
|                  | quid - | four to six  | el]{.mark} | the         |
|                  | manual | sec          |            | product;    |
|                  | s      | onds]{.mark} |            | wash hands  |
|                  | pray]{ |              |            | before      |
|                  | .mark} |              |            | eating,     |
|                  |        |              |            | drinking,   |
|                  |        |              |            | chewing     |
|                  |        |              |            | gum, using  |
|                  |        |              |            | tobacco, or |
|                  |        |              |            | using the   |
|                  |        |              |            | toi         |
|                  |        |              |            | let]{.mark} |
+------------------+--------+--------------+------------+-------------+
| [Shower]{.mark}  | [44    | [spray       | [i         | [wash hands |
| Room Premises    | 446-20 | surface      | nformation | before      |
|                  | -press | until        | not given  | eating,     |
|                  | urized | completely   | on         | drinking,   |
|                  | li     | wet and      | lab        | chewing     |
|                  | quid - | allow to     | el]{.mark} | gum, using  |
|                  | manual | remain wet   |            | tobacco, or |
|                  | s      | for 10       |            | using the   |
|                  | pray]{ | minutes or   |            | toi         |
|                  | .mark} | for air      |            | let]{.mark} |
|                  |        | sanitization |            |             |
|                  |        | spray for    |            |             |
|                  |        | three        |            |             |
|                  |        | sec          |            |             |
|                  |        | onds]{.mark} |            |             |
+------------------+--------+--------------+------------+-------------+
| [Hard Nonporous  | [44    | [spray       | [i         | [wash hands |
| Surface]{.mark}  | 446-20 | surface      | nformation | before      |
|                  | -press | until        | not given  | eating,     |
|                  | urized | completely   | on         | drinking,   |
|                  | li     | wet and      | lab        | chewing     |
|                  | quid - | allow to     | el]{.mark} | gum, using  |
|                  | manual | remain wet   |            | tobacco, or |
|                  | s      | for 10       |            | using the   |
|                  | pray]{ | min          |            | toi         |
|                  | .mark} | utes]{.mark} |            | let]{.mark} |
+------------------+--------+--------------+------------+-------------+
| [Environmental   | [44    | spray        | i          | wash hands  |
| Inanimate Hard   | 446-20 | surface      | nformation | before      |
| Surfaces]{.mark} | -press | until        | not given  | eating,     |
|                  | urized | completely   | on label   | drinking,   |
|                  | li     | wet and      |            | chewing     |
|                  | quid - | allow to     |            | gum, using  |
|                  | manual | remain wet   |            | tobacco, or |
|                  | s      | for 10       |            | using the   |
|                  | pray]{ | minutes      |            | toilet      |
|                  | .mark} |              |            |             |
+------------------+--------+--------------+------------+-------------+
| Garbage Storage  | [44    | [spray       | [i         | [wash hands |
| Premises &       | 446-20 | surface      | nformation | before      |
| Containers       | -press | until        | not given  | eating,     |
|                  | urized | completely   | on         | drinking,   |
|                  | li     | wet and      | lab        | chewing     |
|                  | quid - | allow to     | el]{.mark} | gum, using  |
|                  | manual | remain wet   |            | tobacco, or |
|                  | s      | for 10       |            | using the   |
|                  | pray]{ | minutes or   |            | toi         |
|                  | .mark} | for air      |            | let]{.mark} |
|                  |        | sanitization |            |             |
|                  |        | spray for    |            |             |
|                  |        | three        |            |             |
|                  |        | sec          |            |             |
|                  |        | onds]{.mark} |            |             |
+------------------+--------+--------------+------------+-------------+
| Bathroom         | [44    | [spray       | [i         | [wash hands |
| Premises         | 446-20 | sur          | nformation | before      |
|                  | -press | face]{.mark} | not given  | eating,     |
|                  | urized | until        | on         | drinking,   |
|                  | li     | completely   | lab        | chewing     |
|                  | quid - | wet and      | el]{.mark} | gum, using  |
|                  | manual | allow to     |            | tobacco, or |
|                  | s      | remain wet   |            | using the   |
|                  | pray]{ | for 10       |            | toi         |
|                  | .mark} | minutes or   |            | let]{.mark} |
|                  |        | for air      |            |             |
|                  |        | sanitization |            | []{.mark}   |
|                  |        | spray for    |            |             |
|                  |        | [three       |            | []{.mark}   |
|                  |        | sec          |            |             |
|                  |        | onds]{.mark} |            | []{.mark}   |
|                  |        |              |            |             |
|                  |        |              |            | []{.mark}   |
+------------------+--------+--------------+------------+-------------+
| [Air Treatment   | [1.    | [1. 7 ounces | 1\.        | 1\. do not  |
| (B               | 10     | of product   | i          | use in      |
| athroom)]{.mark} | 807-43 | contains     | nformation | nurseries   |
|                  | -press | 3400         | not given  | or rooms    |
|                  | urized | controlled   | on label   | where       |
|                  | li     | sprays that  |            | infants,    |
|                  | quid - | will last    |            | ill or aged |
|                  | aut    | for 30 days  |            | patients    |
|                  | omatic | when used on |            | are         |
|                  | dispe  | a 24 hour    |            | confined;   |
|                  | nser]{ | basis or 60  |            | food, food  |
|                  | .mark} | days if used |            | contact     |
|                  |        | 12 hours per |            | surfaces    |
|                  |        | day when set |            | and         |
|                  |        | to dispense  |            | utensils    |
|                  |        | every 15     |            | should be   |
|                  |        | minutes      |            | protected   |
|                  |        | (room size   |            | from        |
|                  |        | not          |            | exposure to |
|                  |        | specif       |            | the spray   |
|                  |        | ied)]{.mark} |            | or rinsed   |
|                  |        |              |            | with        |
|                  |        |              |            | potable     |
|                  |        |              |            | water       |
|                  |        |              |            | before use  |
+------------------+--------+--------------+------------+-------------+
|                  | [2.    | [2. 6.2      | [2.        | [2. do not  |
|                  | 94     | ounce of     | sprayed at | contaminate |
|                  | 44-19- | product      | interva    | water, food |
|                  | press  | treats 6,000 | ls]{.mark} | or          |
|                  | urized | cubic feet   |            | f           |
|                  | li     | of closed    |            | eed]{.mark} |
|                  | quid - | air          |            |             |
|                  | aut    | sp           |            |             |
|                  | omatic | ace.]{.mark} |            |             |
|                  | interm |              |            |             |
|                  | ittent |              |            |             |
|                  | a      |              |            |             |
|                  | erosol |              |            |             |
|                  | dispe  |              |            |             |
|                  | nser]{ |              |            |             |
|                  | .mark} |              |            |             |
+------------------+--------+--------------+------------+-------------+
|                  | [3.    | [3. spray    | [3.        | [3. wash    |
|                  | 444    | for three    | i          | hands       |
|                  | 46-20- | sec          | nformation | before      |
|                  | p      | onds]{.mark} | not given  | eating,     |
|                  | ressur |              | on         | drinking,   |
|                  | ized]{ |              | lab        | chewing     |
|                  | .mark} |              | el]{.mark} | gum, using  |
|                  | li     |              |            | tobacco, or |
|                  | quid - |              |            | using the   |
|                  | [      |              |            | toi         |
|                  | manual |              |            | let]{.mark} |
|                  | s      |              |            |             |
|                  | pray]{ |              |            |             |
|                  | .mark} |              |            |             |
+------------------+--------+--------------+------------+-------------+
|                  | [4.    | [4. spray    | [4. spray  | [4. food,   |
|                  | 108    | the room     | several    | food        |
|                  | 07-37- | until a      | times per  | contact     |
|                  | press  | light fog    | d          | surfaces    |
|                  | urized | forms -      | ay]{.mark} | and         |
|                  | li     | spray 6 to 8 |            | utensils    |
|                  | quid - | seconds in   |            | should be   |
|                  | manual | an average   |            | protected   |
|                  | s      | room (10 X   |            | from        |
|                  | pray]{ | 10)]{.mark}  |            | exposure to |
|                  | .mark} |              |            | the spray   |
|                  |        |              |            | or rinsed   |
|                  |        |              |            | with        |
|                  |        |              |            | potable     |
|                  |        |              |            | water       |
|                  |        |              |            | before      |
|                  |        |              |            | use]{.mark} |
+------------------+--------+--------------+------------+-------------+
| []{.mark}        | [5.    | [5. fill     | [5. repeat | [5. avoid   |
|                  | 5      | average size | a          | contaminat  |
| []{.mark}        | 1838-1 | room with    | pplication | ion]{.mark} |
|                  | -press | mist         | several    | of food     |
| []{.mark}        | urized | (a           | times      |             |
|                  | li     | pproximately | dai        |             |
| []{.mark}        | quid - | 15           | ly]{.mark} |             |
|                  | manual | spr          |            |             |
|                  | opera  | ays)]{.mark} |            |             |
|                  | tion]{ |              |            |             |
|                  | .mark} |              |            |             |
+------------------+--------+--------------+------------+-------------+
|                  | [6.    | [6. spray    | [6.        | [6. avoid   |
|                  | 48     | upward in    | i          | contact     |
|                  | 22-293 | center       | nformation | with food   |
|                  | -press | of]{.mark}   | not given  | and food    |
|                  | urized | room for [10 | on         | utens       |
|                  | li     | seconds in   | lab        | ils]{.mark} |
|                  | quid - | average room | el]{.mark} |             |
|                  | manual | of 12 X 12 X |            |             |
|                  | s      | 9]{.mark}    |            |             |
|                  | pray]{ |              |            |             |
|                  | .mark} |              |            |             |
+------------------+--------+--------------+------------+-------------+
|                  | [7.    | [7. one      | [7.        | [7.         |
|                  | 482    | second spray | i          | information |
|                  | 2-531- | for a 9.5 X  | nformation | not given   |
|                  | press  | 9 X 7        | not given  | on          |
|                  | urized | room]{.mark} | on         | la          |
|                  | li     |              | lab        | bel]{.mark} |
|                  | quid - |              | el]{.mark} |             |
|                  | wall   |              |            |             |
|                  | m      |              |            |             |
|                  | ounted |              |            |             |
|                  | unit   |              |            |             |
|                  | in     |              |            |             |
|                  | cont   |              |            |             |
|                  | inuous |              |            |             |
|                  | action |              |            |             |
|                  | a      |              |            |             |
|                  | erosol |              |            |             |
|                  | can]{  |              |            |             |
|                  | .mark} |              |            |             |
+------------------+--------+--------------+------------+-------------+
|                  | 8\.    | [8. spray    | [8. spray  | [8. food,   |
|                  | [1080  | the room     | several    | food        |
|                  | 7-24 - | until a      | times per  | contact     |
|                  | press  | light fog    | d          | surfaces    |
|                  | urized | forms -      | ay]{.mark} | and         |
|                  | l      | spray 6 to 8 |            | utensils    |
|                  | iquid- | seconds in   |            | should be   |
|                  | manual | an average   |            | protected   |
|                  | s      | room (10 X   |            | from        |
|                  | pray]{ | 10)]{.mark}  |            | exposure to |
|                  | .mark} |              |            | the spray   |
|                  |        |              |            | or rinsed   |
|                  |        |              |            | with        |
|                  |        |              |            | potable     |
|                  |        |              |            | water       |
|                  |        |              |            | before      |
|                  |        |              |            | use]{.mark} |
+------------------+--------+--------------+------------+-------------+
| []{.mark}        | [9.    | [9. using a  | [9.        | [9.         |
|                  | 4      | 120 μl valve | i          | information |
|                  | 822-53 | with .22     | nformation | not given   |
|                  | 1-wall | ounces of    | not given  | on          |
|                  | m      | prod         | on         | la          |
|                  | ounted | uct:]{.mark} | lab        | bel]{.mark} |
|                  | unit   |              | el]{.mark} |             |
|                  | in     | [-1 time for |            |             |
|                  | m      | 2.5 X 2.5 X  |            |             |
|                  | etered | 7            |            |             |
|                  | dose   | room]{.mark} |            |             |
|                  | a      |              |            |             |
|                  | erosol | [-2 times    |            |             |
|                  | can    | for 4 X 3 X  |            |             |
|                  | o]{.   | 7            |            |             |
|                  | mark}r | room]{.mark} |            |             |
|                  | [press |              |            |             |
|                  | urized | [-3 times    |            |             |
|                  | li     | for 4.5 X 4  |            |             |
|                  | quid - | X 7          |            |             |
|                  | hand   | room]{.mark} |            |             |
|                  | held   |              |            |             |
|                  | unit]{ | [-4 times    |            |             |
|                  | .mark} | for 5 X 5 X  |            |             |
|                  |        | 7            |            |             |
|                  |        | room]{.mark} |            |             |
|                  |        |              |            |             |
|                  |        | []{.mark}    |            |             |
|                  |        |              |            |             |
|                  |        | [using a 185 |            |             |
|                  |        | μl           |            |             |
|                  |        | va           |            |             |
|                  |        | lve-]{.mark} |            |             |
|                  |        |              |            |             |
|                  |        | [-1 time for |            |             |
|                  |        | 3 X 3 X 7    |            |             |
|                  |        | room]{.mark} |            |             |
|                  |        |              |            |             |
|                  |        | [-2 times    |            |             |
|                  |        | for 4.5 X 4  |            |             |
|                  |        | X 7          |            |             |
|                  |        | room]{.mark} |            |             |
|                  |        |              |            |             |
|                  |        | [-3 times    |            |             |
|                  |        | for a 5.5 X  |            |             |
|                  |        | 5 X 7        |            |             |
|                  |        | room]{.mark} |            |             |
|                  |        |              |            |             |
|                  |        | [4 times for |            |             |
|                  |        | a 6 X 6 X 7  |            |             |
|                  |        | room]{.mark} |            |             |
+------------------+--------+--------------+------------+-------------+
| [Locker Room     | [44    | [spray       | i          | [wash hands |
| Premises]{.mark} | 446-20 | surface      | nformation | before      |
|                  | -press | until        | not given  | eating,     |
|                  | urized | completely   | on label   | drinking,   |
|                  | li     | wet and      |            | chewing     |
|                  | quid - | allow to     |            | gum, using  |
|                  | manual | remain wet   |            | tobacco, or |
|                  | s      | for 10       |            | using the   |
|                  | pray]{ | minutes or   |            | toi         |
|                  | .mark} | for air      |            | let]{.mark} |
|                  |        | sanitization |            |             |
|                  |        | spray for    |            |             |
|                  |        | three        |            |             |
|                  |        | sec          |            |             |
|                  |        | onds]{.mark} |            |             |
+------------------+--------+--------------+------------+-------------+
| [Air Treatment   | [1.    | [1. 7 ounces | [1.        | [1. do not  |
| (Locker          | 10     | of product   | i          | use in      |
| Room)]{.mark}    | 807-43 | contains     | nformation | nurseries   |
|                  | -press | 3400         | not given  | or rooms    |
| []{.mark}        | urized | controlled   | on         | where       |
|                  | li     | sprays that  | lab        | infants,    |
| []{.mark}        | quid - | will last    | el]{.mark} | ill or aged |
|                  | aut    | for 30 days  |            | patients    |
| []{.mark}        | omatic | when used on |            | are         |
|                  | dispe  | a 24 hour    |            | confined;   |
| []{.mark}        | nser]{ | basis or 60  |            | food, food  |
|                  | .mark} | days if used |            | contact     |
| []{.mark}        |        | 12 hours per |            | surfaces    |
|                  |        | day when set |            | and         |
| []{.mark}        |        | to dispense  |            | utensils    |
|                  |        | every 15     |            | should be   |
| []{.mark}        |        | minutes      |            | protected   |
|                  |        | (room size   |            | from        |
| []{.mark}        |        | not          |            | exposure to |
|                  |        | specif       |            | the spray   |
| []{.mark}        |        | ied)]{.mark} |            | or rinsed   |
|                  |        |              |            | with        |
| []{.mark}        |        |              |            | potable     |
|                  |        |              |            | water       |
| []{.mark}        |        |              |            | before      |
|                  |        |              |            | use]{.mark} |
| []{.mark}        |        |              |            |             |
|                  |        |              |            |             |
| []{.mark}        |        |              |            |             |
+------------------+--------+--------------+------------+-------------+
|                  | [2.    | [2. 6.2      | [2.        | [2. do not  |
|                  | 9      | ounces       | sprayed at | contaminate |
|                  | 444-19 | treats 6,000 | interva    | water, food |
|                  | -press | cubic feet   | ls]{.mark} | or          |
|                  | urized | of closed    |            | f           |
|                  | li     | air          |            | eed]{.mark} |
|                  | quid - | sp           |            |             |
|                  | aut    | ace.]{.mark} |            |             |
|                  | omatic |              |            |             |
|                  | interm |              |            |             |
|                  | ittent |              |            |             |
|                  | a      |              |            |             |
|                  | erosol |              |            |             |
|                  | dispe  |              |            |             |
|                  | nser]{ |              |            |             |
|                  | .mark} |              |            |             |
+------------------+--------+--------------+------------+-------------+
|                  | [3.    | [3. spray    | 3\. spray  | [3. food,   |
|                  | 10     | the room     | several    | food        |
|                  | 807-37 | until a      | times per  | contact     |
|                  | &      | light fog    | day        | surfaces    |
|                  | 10     | forms -      |            | and         |
|                  | 807-24 | spray 6 to 8 |            | utensils    |
|                  | -press | seconds in   |            | should be   |
|                  | urized | an average   |            | protected   |
|                  | li     | room (10 X   |            | from        |
|                  | quid - | 10)]{.mark}  |            | exposure to |
|                  | manual |              |            | the spray   |
|                  | s      |              |            | or rinsed   |
|                  | pray]{ |              |            | with        |
|                  | .mark} |              |            | potable     |
|                  |        |              |            | water       |
|                  | []{    |              |            | before      |
|                  | .mark} |              |            | use]{.mark} |
+------------------+--------+--------------+------------+-------------+
| [Birds (Caged)   | [11    | [spray       | [no more   | information |
| (Animal          | 715-20 | lightly with | than 2     | not given   |
| Tr               | -press | one burst of | times per  | on label    |
| eatment)]{.mark} | urized | 2 or 3       | we         |             |
|                  | l      | sec          | ek]{.mark} |             |
|                  | iquid- | onds]{.mark} |            |             |
|                  | manual |              |            |             |
|                  | s      |              |            |             |
|                  | pray]{ |              |            |             |
|                  | .mark} |              |            |             |
+------------------+--------+--------------+------------+-------------+
| [Pet Bird Cages  | [11    | [thoroughly  | [regular   | [           |
| (Enclosed        | 715-20 | spray        | interva    | information |
| Premise          | -press | perches and  | ls]{.mark} | not given   |
| Tr               | urized | cage]{.mark} |            | on          |
| eatment)]{.mark} | l      |              |            | la          |
|                  | iquid- |              |            | bel]{.mark} |
|                  | manual |              |            |             |
|                  | s      |              |            |             |
|                  | pray]{ |              |            |             |
|                  | .mark} |              |            |             |
+------------------+--------+--------------+------------+-------------+
| [Air Treatment   | [1.    | 1\. [using a | [1.        | [1. do not  |
| (Pet Kennels &   | 4822   | 120 μl valve | i          | position    |
| Enclosed Premise | -531-] | with .22     | nformation | near heat   |
| Tr               | {.mark | ounces of    | not given  | or          |
| eatment)]{.mark} | }press | prod         | on         | electrical  |
|                  | urized | uct:]{.mark} | lab        | sources; do |
|                  | li     |              | el]{.mark} | not spray   |
|                  | quid - | -1 time for  |            | directly    |
|                  | wall   | 2.5 X 2.5 X  |            | onto        |
|                  | m      | 7 room       |            | surfaces;   |
|                  | ounted |              |            | in case of  |
|                  | unit   | -2 times for |            | contact     |
|                  | in     | 4 X 3 X 7    |            | with        |
|                  | m      | room         |            | surfaces,   |
|                  | etered |              |            | wipe        |
|                  | dose   | -3 times for |            | immediately |
|                  | a      | 4.5 X 4 X 7  |            | with damp   |
|                  | erosol | room         |            | clo         |
|                  | can or |              |            | th.]{.mark} |
|                  | hand   | -4 times for |            |             |
|                  | held   | 5 X 5 X 7    |            |             |
|                  | unit   | room         |            |             |
|                  |        |              |            |             |
|                  |        | using a 185  |            |             |
|                  |        | [μl]{.mark}  |            |             |
|                  |        | valve-       |            |             |
|                  |        |              |            |             |
|                  |        | -1 time for  |            |             |
|                  |        | 3 X 3 X 7    |            |             |
|                  |        | room         |            |             |
|                  |        |              |            |             |
|                  |        | -2 times for |            |             |
|                  |        | 4.5 X 4 X 7  |            |             |
|                  |        | room         |            |             |
|                  |        |              |            |             |
|                  |        | -3 times for |            |             |
|                  |        | a 5.5 X 5 X  |            |             |
|                  |        | 7 room       |            |             |
|                  |        |              |            |             |
|                  |        | 4 times for  |            |             |
|                  |        | a 6 X 6 X 7  |            |             |
|                  |        | room         |            |             |
+------------------+--------+--------------+------------+-------------+
|                  | [2.    | 2\. one      | [2.        | [2.]{.mark} |
|                  | 4822-  | second spray | i          | information |
|                  | 531-]{ | for a 9.5 X  | nformation | not given   |
|                  | .mark} | 9 X 7 room   | not given  | on label    |
|                  | press  |              | on         |             |
|                  | urized |              | lab        |             |
|                  | li     |              | el]{.mark} |             |
|                  | quid - |              |            |             |
|                  | wall   |              |            |             |
|                  | m      |              |            |             |
|                  | ounted |              |            |             |
|                  | unit   |              |            |             |
|                  | in     |              |            |             |
|                  | cont   |              |            |             |
|                  | inuous |              |            |             |
|                  | action |              |            |             |
|                  | a      |              |            |             |
|                  | erosol |              |            |             |
|                  | can    |              |            |             |
+------------------+--------+--------------+------------+-------------+
|                  | [3.    | [3. spray    | [3.        | [3. avoid   |
|                  | 4822   | upward in    | i          | contact     |
|                  | -293-] | center       | nformation | with food   |
|                  | {.mark | of]{.mark}   | not given  | and food    |
|                  | }press | room for [10 | on         | utens       |
|                  | urized | seconds in   | lab        | ils]{.mark} |
|                  | liquid | average room | el]{.mark} |             |
|                  | [-     | of 12 X 12 X |            |             |
|                  | manual | 9]{.mark}    |            |             |
|                  | s      |              |            |             |
|                  | pray]{ |              |            |             |
|                  | .mark} |              |            |             |
+------------------+--------+--------------+------------+-------------+

+------------------+--------+--------------+------------+-------------+
| **[5. Medical    |        |              |            |             |
| premises and     |        |              |            |             |
| equ              |        |              |            |             |
| ipment]{.mark}** |        |              |            |             |
+------------------+--------+--------------+------------+-------------+
| Air treatments   | [1.    | [1. using a  | 1\.        | 1\. do not  |
| (sickroom)       | 482    | 120 μl valve | i          | position    |
|                  | 2-531- | with .22     | nformation | near heat   |
|                  | press  | ounces of    | not given  | or          |
|                  | urized | prod         | on label   | electrical  |
|                  | li     | uct:]{.mark} |            | sources; do |
|                  | quid - |              |            | not spray   |
|                  | wall   | []{.mark}    |            | directly    |
|                  | m      |              |            | onto        |
|                  | ounted | [-1 time for |            | surfaces;   |
|                  | unit   | 2.5 X 2.5 X  |            | in case of  |
|                  | in     | 7            |            | contact     |
|                  | m      | room]{.mark} |            | with        |
|                  | etered |              |            | surfaces,   |
|                  | dose   | [-2 times    |            | wipe        |
|                  | a      | for 4 X 3 X  |            | immediately |
|                  | erosol | 7            |            | with damp   |
|                  | can or | room]{.mark} |            | cloth.      |
|                  | hand   |              |            |             |
|                  | held   | [-3 times    |            |             |
|                  | unit]{ | for 4.5 X 4  |            |             |
|                  | .mark} | X 7          |            |             |
|                  |        | room]{.mark} |            |             |
|                  |        |              |            |             |
|                  |        | [-4 times    |            |             |
|                  |        | for 5 X 5 X  |            |             |
|                  |        | 7            |            |             |
|                  |        | room]{.mark} |            |             |
|                  |        |              |            |             |
|                  |        | []{.mark}    |            |             |
|                  |        |              |            |             |
|                  |        | [using a 185 |            |             |
|                  |        | μl           |            |             |
|                  |        | va           |            |             |
|                  |        | lve-]{.mark} |            |             |
|                  |        |              |            |             |
|                  |        | [-1 time for |            |             |
|                  |        | 3 X 3 X 7    |            |             |
|                  |        | room]{.mark} |            |             |
|                  |        |              |            |             |
|                  |        | [-2 times    |            |             |
|                  |        | for 4.5 X 4  |            |             |
|                  |        | X 7          |            |             |
|                  |        | room]{.mark} |            |             |
|                  |        |              |            |             |
|                  |        | [-3 times    |            |             |
|                  |        | for a 5.5 X  |            |             |
|                  |        | 5 X 7        |            |             |
|                  |        | room]{.mark} |            |             |
|                  |        |              |            |             |
|                  |        | [4 times for |            |             |
|                  |        | a 6 X 6 X 7  |            |             |
|                  |        | room]{.mark} |            |             |
+------------------+--------+--------------+------------+-------------+
|                  | [2.    | [2. one      | [2.        | [2.         |
|                  | 482    | second spray | i          | information |
|                  | 2-531- | for a 9.5 X  | nformation | not given   |
|                  | press  | 9 X 7        | not given  | on          |
|                  | urized | room]{.mark} | on         | la          |
|                  | li     |              | lab        | bel]{.mark} |
|                  | quid - |              | el]{.mark} |             |
|                  | wall   |              |            |             |
|                  | m      |              |            |             |
|                  | ounted |              |            |             |
|                  | unit   |              |            |             |
|                  | in     |              |            |             |
|                  | cont   |              |            |             |
|                  | inuous |              |            |             |
|                  | action |              |            |             |
|                  | a      |              |            |             |
|                  | erosol |              |            |             |
|                  | can]{  |              |            |             |
|                  | .mark} |              |            |             |
+------------------+--------+--------------+------------+-------------+
| [Air treatment   | [1.    | 1\. spray    | 1\. repeat | 1\. spray   |
| (h               | 518    | for one      | a          | away from   |
| ospital)]{.mark} | 38-2 - | second       | pplication | drapes,     |
|                  | press  | toward       | several    | walls,      |
| []{.mark}        | urized | center of    | times      | plastic,    |
|                  | l      | average size | daily      | vinyl,      |
|                  | iquid- | room (10 X   |            | painted or  |
|                  | manual | 14 X 8)      |            | varnished   |
|                  | s      |              |            | surfaces    |
|                  | pray]{ |              |            |             |
|                  | .mark} |              |            |             |
+------------------+--------+--------------+------------+-------------+
|                  | [2.    | [2. 7 ounces | 2\.        | 2\. avoid   |
|                  | 51     | of product   | product    | co          |
|                  | 838-1- | for each 6,  | sprayed at | ntamination |
|                  | ready  | 000 cubic    | intervals  | of food     |
|                  | to use | feet of      |            |             |
|                  | solu   | closed air   |            |             |
|                  | tion - | s            |            |             |
|                  | aut    | pace]{.mark} |            |             |
|                  | omatic |              |            |             |
|                  | dispe  |              |            |             |
|                  | nser]{ |              |            |             |
|                  | .mark} |              |            |             |
+------------------+--------+--------------+------------+-------------+
|                  | [3.    | [3. fill     | 3\. repeat | 3\. avoid   |
|                  | 51     | average size | a          | co          |
|                  | 838-1- | room with    | pplication | ntamination |
|                  | ready  | mist         | several    | of food     |
|                  | to use | (a           | times      |             |
|                  | solu   | pproximately | daily      |             |
|                  | tion - | 15           |            |             |
|                  | for    | spr          |            |             |
|                  | manual | ays)]{.mark} |            |             |
|                  | opera  |              |            |             |
|                  | tion]{ |              |            |             |
|                  | .mark} |              |            |             |
|                  |        |              |            |             |
|                  | []{    |              |            |             |
|                  | .mark} |              |            |             |
+------------------+--------+--------------+------------+-------------+
|                  | 4\.    | 4\. spray    | 4\. spray  | [4. food,   |
|                  | 10     | the room     | several    | food        |
|                  | 807-37 | until a      | times per  | contact     |
|                  | &      | light fog    | day        | surfaces    |
|                  | 1080   | forms -      |            | and         |
|                  | 7-24 - | spray 6 to 8 |            | utensils    |
|                  | press  | seconds in   |            | should be   |
|                  | urized | an average   |            | protected   |
|                  | li     | room (10 X   |            | from        |
|                  | quid - | 10)          |            | exposure to |
|                  | manual |              |            | the spray   |
|                  | spray  |              |            | or rinsed   |
|                  |        |              |            | with        |
|                  |        |              |            | potable     |
|                  |        |              |            | water       |
|                  |        |              |            | before      |
|                  |        |              |            | use]{.mark} |
+------------------+--------+--------------+------------+-------------+
|                  | 5\.    | 5\. [spray   | 5\.        | [5. avoid   |
|                  | [48    | upward in    | i          | contact     |
|                  | 22-293 | center       | nformation | with        |
|                  | -]{    | of]{.mark}   | not given  | f           |
|                  | .mark} | room for [10 | on label   | ood]{.mark} |
|                  | press  | seconds in   |            | and food    |
|                  | urized | average room |            | utensils    |
|                  | liquid | of 12 X 12 X |            |             |
|                  | [-     | 9]{.mark}    |            |             |
|                  | manual |              |            |             |
|                  | s      |              |            |             |
|                  | pray]{ |              |            |             |
|                  | .mark} |              |            |             |
+------------------+--------+--------------+------------+-------------+
|                  | 6\.    | 6\. [spray   | 6\.        | [6. wash    |
|                  | [44446 | for three    | i          | hands       |
|                  | -20-]{ | sec          | nformation | before      |
|                  | .mark} | onds]{.mark} | not given  | eating,     |
|                  | [press |              | on label   | drinking,   |
|                  | urized |              |            | chewing     |
|                  | li     |              |            | gum, using  |
|                  | quid]{ |              |            | tobacco, or |
|                  | .mark} |              |            | using the   |
|                  | [-     |              |            | toi         |
|                  | manual |              |            | let]{.mark} |
|                  | s      |              |            |             |
|                  | pray]{ |              |            |             |
|                  | .mark} |              |            |             |
+------------------+--------+--------------+------------+-------------+
|                  | [7.    | [7. 6.2      | [7.        | [7. do not  |
|                  | 9      | ounces of    | sprayed at | contaminate |
|                  | 444-19 | product      | interva    | water, food |
|                  | -]{    | treats 6,000 | ls]{.mark} | or          |
|                  | .mark} | cubic feet   |            | f           |
|                  | press  | of closed    |            | eed]{.mark} |
|                  | urized | air          |            |             |
|                  | liquid | s            |            |             |
|                  | [-     | pace]{.mark} |            |             |
|                  | aut    |              |            |             |
|                  | omatic |              |            |             |
|                  | interm |              |            |             |
|                  | ittent |              |            |             |
|                  | a      |              |            |             |
|                  | erosol |              |            |             |
|                  | dispe  |              |            |             |
|                  | nser]{ |              |            |             |
|                  | .mark} |              |            |             |
+------------------+--------+--------------+------------+-------------+
| [Hospital        | [44    | [dec         | [i         | [dispose of |
| (Premises and    | 446-20 | ontamination | nformation | infectious  |
| Ma               | -press | against      | not given  | materials   |
| terials)]{.mark} | urized | HIV-1 of     | on         | according   |
|                  | liquid | surf         | lab        | to federal, |
|                  | -      | aces/objects | el]{.mark} | state and   |
|                  | manual | soiled with  |            | local       |
|                  | s      | blood/body   |            | regulati    |
|                  | pray]{ | fluids -     |            | ons]{.mark} |
|                  | .mark} | 1800 ppm of  |            |             |
|                  |        | active       |            |             |
|                  |        | quaternary   |            |             |
|                  |        | water for a  |            |             |
|                  |        | contact time |            |             |
|                  |        | of 10        |            |             |
|                  |        | minutes at   |            |             |
|                  |        | room         |            |             |
|                  |        | t            |            |             |
|                  |        | emperature - |            |             |
|                  |        | use a 10     |            |             |
|                  |        | minute       |            |             |
|                  |        | contact time |            |             |
|                  |        | for          |            |             |
|                  |        | disinfection |            |             |
|                  |        | against all  |            |             |
|                  |        | other        |            |             |
|                  |        | bacteria and |            |             |
|                  |        | fungi        |            |             |
|                  |        | cla          |            |             |
|                  |        | imed]{.mark} |            |             |
+------------------+--------+--------------+------------+-------------+

> **Appendix B: Table of Generic Data Requirements and Studies Used to
> Make the Reregistration Decision**

Number range CHAPTER**[Guide To Appendix B]{.underline}**

> Appendix B lists the **generic** (not product specific) data
> requirements which support the re-registration of Triethylene Glycol
> (TEG). These requirements apply to TEG in all products, including data
> requirements for which a technical grade active ingredient is the test
> substance. The data table is organized in the following formats:
>
> 1\. **[Data Requirement]{.underline}** (Columns 1 and 2). The data
> requirements are listed by Guideline Number. The first column lists
> the new Part 158 Guideline numbers, and the second column lists the
> old Part 158 Guideline numbers. Each Guideline Number has an
> associated test protocol set forth in the Pesticide Assessment
> Guidance, which are available on the EPA website.

2.  **[Guideline Description]{.underline}** (Column 3). Identifies the
    guideline type.

    3\. **[Use Pattern]{.underline}** (Column 4). This column indicates
    the standard Antimicrobial Division use patterns categories for
    which the generic (not product specific) data requirements apply.
    The number designations are used in Appendix B.

    \(1\) Agricultural premises and equipment

    \(2\) Food handling/ storage establishments premises and equipment

    \(3\) Commercial, institutional and industrial premises and
    equipment

    \(4\) Residential and public access premises

    \(5\) Medical premises and equipment

    \(6\) Human water systems

    \(7\) Materials preservatives

    \(8\) Industrial processes and water systems

    \(9\) Antifouling coatings

    \(10\) Wood preservatives

    \(11\) Swimming pools

    \(12\) Aquatic areas

> 4\. **[Bibliographic Citation]{.underline}** (Column 5). If the Agency
> has data in its files to support a specific generic Guideline
> requirement, this column will identify each study by a "Master Record
> Identification (MRID) number. The listed studies are considered
> "valid" and acceptable for satisfying the Guideline requirement. Refer
> to the Bibliography appendix for a complete citation of each study.

+------+------+---------------------------------+-------+--------------+
| **   |      |                                 |       | **C          |
| DATA |      |                                 |       | ITATION(S)** |
| R    |      |                                 |       |              |
| EQUI |      |                                 |       |              |
| REME |      |                                 |       |              |
| NT** |      |                                 |       |              |
+======+======+=================================+=======+==============+
| *    | *    | **Study Title**                 | **Use | **MRID       |
| *New | *Old |                                 | Patt  | Number**     |
| G    | G    |                                 | ern** |              |
| uide | uide |                                 |       |              |
| line | line |                                 |       |              |
| Numb | Numb |                                 |       |              |
| er** | er** |                                 |       |              |
+------+------+---------------------------------+-------+--------------+
| **[T |      |                                 |       |              |
| ECHN |      |                                 |       |              |
| ICAL |      |                                 |       |              |
| G    |      |                                 |       |              |
| RADE |      |                                 |       |              |
| AC   |      |                                 |       |              |
| TIVE |      |                                 |       |              |
| IN   |      |                                 |       |              |
| GRED |      |                                 |       |              |
| IENT |      |                                 |       |              |
| (T   |      |                                 |       |              |
| GAI) |      |                                 |       |              |
| CHEM |      |                                 |       |              |
| ISTR |      |                                 |       |              |
| Y]{. |      |                                 |       |              |
| unde |      |                                 |       |              |
| rlin |      |                                 |       |              |
| e}** |      |                                 |       |              |
+------+------+---------------------------------+-------+--------------+
| 830. | 61-1 | Product Identity and            | 2,    | 42814401 and |
| 1550 |      | Composition                     | 3,4,5 | 42211801     |
+------+------+---------------------------------+-------+--------------+
| 830. | 6    | Starting Materials and          | 2,    | 42814401     |
| 1600 | 1-2A | Manufacturing Process           | 3,4,5 |              |
| 830. |      |                                 |       |              |
| 1620 |      |                                 |       |              |
|      |      |                                 |       |              |
| 830. |      |                                 |       |              |
| 1650 |      |                                 |       |              |
+------+------+---------------------------------+-------+--------------+
| 830. | 6    | Formation of Impurities         | 2,    | 42814401     |
| 1670 | 1-2B |                                 | 3,4,5 |              |
+------+------+---------------------------------+-------+--------------+
| 830. | 62-1 | Preliminary Analysis            | 2,    | 42814402     |
| 1700 |      |                                 | 3,4,5 |              |
+------+------+---------------------------------+-------+--------------+
| 830. | 62-2 | Certification of Limits         | 2,    | 42814402     |
| 1750 |      |                                 | 3,4,5 |              |
+------+------+---------------------------------+-------+--------------+
| 830. | 62-3 | Analytical Method               | 2,    | 42814402     |
| 1800 |      |                                 | 3,4,5 |              |
+------+------+---------------------------------+-------+--------------+
| 830. | 63-2 | Color                           | 2,    | 42814403 and |
| 6302 |      |                                 | 3,4,5 | 42211801     |
+------+------+---------------------------------+-------+--------------+
| 830. | 63-3 | Physical State                  | 2,    | 42814403 and |
| 6303 |      |                                 | 3,4,5 | 42211801     |
+------+------+---------------------------------+-------+--------------+
| 830. | 63-4 | Odor                            | 2,    | 42814403 and |
| 6304 |      |                                 | 3,4,5 | 42211801     |
+------+------+---------------------------------+-------+--------------+
| 830. | 63-5 | Melting Point                   | 2,    | not required |
| 7200 |      |                                 | 3,4,5 |              |
+------+------+---------------------------------+-------+--------------+
| 830. | 63-6 | Boiling Point                   | 2,    | 42814403     |
| 7220 |      |                                 | 3,4,5 |              |
+------+------+---------------------------------+-------+--------------+
| 830. | 63-7 | Density                         | 2,    | 42814403     |
| 7300 |      |                                 | 3,4,5 |              |
+------+------+---------------------------------+-------+--------------+
| 830. | 63-8 | Solubility                      | 2,    | 42814403     |
| 7840 |      |                                 | 3,4,5 |              |
|      |      |                                 |       |              |
| 830. |      |                                 |       |              |
| 7860 |      |                                 |       |              |
+------+------+---------------------------------+-------+--------------+
| 830. | 63-9 | Vapor Pressure                  | 2,    | 42814403     |
| 7950 |      |                                 | 3,4,5 |              |
+------+------+---------------------------------+-------+--------------+
| 830. | 6    | Dissociation Constant in Water  | [     | [wa          |
| 7370 | 3-10 |                                 | 2,3,4 | ived]{.mark} |
|      |      |                                 | ,5]{. |              |
|      |      |                                 | mark} |              |
+------+------+---------------------------------+-------+--------------+
| 830. | 6    | Partition Coefficient           | 2,    | [4281        |
| 7550 | 3-11 | (Octanol/Water)                 | 3,4,5 | 4403]{.mark} |
|      |      |                                 |       |              |
| 830. |      |                                 |       |              |
| 7560 |      |                                 |       |              |
|      |      |                                 |       |              |
| 830. |      |                                 |       |              |
| 7570 |      |                                 |       |              |
+------+------+---------------------------------+-------+--------------+
| 830. | 6    | pH                              | 2,    | 42814401;    |
| 7000 | 3-12 |                                 | 3,4,5 | 42211801;    |
|      |      |                                 |       | 42814403     |
+------+------+---------------------------------+-------+--------------+
| 830. | 6    | Stability                       | 2,    | 42814401;    |
| 6313 | 3-13 |                                 | 3,4,5 | 42211801;    |
|      |      |                                 |       | 42814403     |
+------+------+---------------------------------+-------+--------------+
| 830. | 6    | Oxidizing/Reducing Action       | 2,    | 42814403     |
| 6314 | 3-14 |                                 | 3,4,5 |              |
+------+------+---------------------------------+-------+--------------+
| 830. | 6    | Flammability                    | 2,    | 42814403     |
| 6315 | 3-15 |                                 | 3,4,5 |              |
+------+------+---------------------------------+-------+--------------+
| 830. | 6    | Explodability                   | 2,    | 42814403     |
| 6316 | 3-16 |                                 | 3,4,5 |              |
+------+------+---------------------------------+-------+--------------+
| 830. | 6    | Storage Stability               | 2,    | 42814403     |
| 6317 | 3-17 |                                 | 3,4,5 |              |
+------+------+---------------------------------+-------+--------------+
| 830. | 6    | Viscosity                       | 2,    | 42814403     |
| 7100 | 3-18 |                                 | 3,4,5 |              |
+------+------+---------------------------------+-------+--------------+
| 830. | 6    | Miscibility                     | 2,    | 42814403     |
| 6319 | 3-19 |                                 | 3,4,5 |              |
+------+------+---------------------------------+-------+--------------+
| 830. | 6    | Corrosion Characteristics       | 2,    | 42814403     |
| 6320 | 3-20 |                                 | 3,4,5 |              |
+------+------+---------------------------------+-------+--------------+
| 830. | 6    | Dielectric breakdown voltage    | 2,    | 42814403     |
| 6321 | 3-21 |                                 | 3,4,5 |              |
+------+------+---------------------------------+-------+--------------+
| *    |      |                                 |       |              |
| *[EC |      |                                 |       |              |
| OLOG |      |                                 |       |              |
| ICAL |      |                                 |       |              |
| EF   |      |                                 |       |              |
| FECT |      |                                 |       |              |
| S]{. |      |                                 |       |              |
| unde |      |                                 |       |              |
| rlin |      |                                 |       |              |
| e}** |      |                                 |       |              |
+------+------+---------------------------------+-------+--------------+
| 850. | 71-1 | Avian Acute Oral Toxicity       | All   | waived due   |
| 2100 |      | Test - Quail/duck               |       | to high      |
|      |      |                                 |       | volatility   |
|      |      |                                 |       | and low      |
|      |      |                                 |       | toxicity     |
+------+------+---------------------------------+-------+--------------+
| 850. | 72-1 | Fish Acute Toxicity - Rainbow   | All   | waived due   |
| 1075 | C    | Trout                           |       | to high      |
|      |      |                                 |       | volatility   |
|      |      |                                 |       | and low      |
|      |      |                                 |       | toxicity     |
+------+------+---------------------------------+-------+--------------+
| 850. | 72-1 | Fish Acute Toxicity - Fathead   | All   | waived due   |
| 1075 | C    | Minnow                          |       | to high      |
|      |      |                                 |       | volatility   |
|      |      |                                 |       | and low      |
|      |      |                                 |       | toxicity     |
+------+------+---------------------------------+-------+--------------+
| 850. | 7    | Acute Aquatic Invertebrate      | All   | waived due   |
| 1010 | 2-2A | Toxicity                        |       | to high      |
|      |      |                                 |       | volatility   |
|      |      |                                 |       | and low      |
|      |      |                                 |       | toxicity     |
+------+------+---------------------------------+-------+--------------+
| n    | n    | Other published                 | n/a   | The below    |
| on-g | on-g | literature/extraneous           |       | list not     |
| uide | uide | submissions:                    |       | required for |
| line | line |                                 |       | current      |
|      |      | 1\. Mysid (*Mysidopsis bahia)*- |       | uses;        |
|      |      | 96-hour static acute; toxicity  |       | available in |
|      |      | LC50 = 11,000 ppm               |       | open         |
|      |      |                                 |       | literature:  |
|      |      | 2\. Sheepshead minnow           |       |              |
|      |      | (*Cyprinodon variegatus*) -     |       | 1\. 40228401 |
|      |      | 96-hour static acute; toxicity  |       |              |
|      |      | LC50 = 48,000 ppm               |       | 2\. 40228401 |
|      |      |                                 |       |              |
|      |      | 3\. Bluegill sunfish (*Lepomis  |       | 3\. Open     |
|      |      | macrochirus*) - 96 hour static  |       | Literature   |
|      |      | acute; toxicity LC50 \> 10,000  |       |              |
|      |      | ppm                             |       | 4\. Open     |
|      |      |                                 |       | Literature   |
|      |      | *4. Menidia beryllina* - 96     |       |              |
|      |      | hour static; toxicity LC50 \>   |       | 5\. Open     |
|      |      | 10,000 ppm                      |       | Literature   |
|      |      |                                 |       |              |
|      |      | 5\. Fathead minnow (*Pimephales |       |              |
|      |      | promelas*) - 96 hour            |       |              |
|      |      | flow-through; toxicity - LC 50  |       |              |
|      |      | 59,900 - 77,400 ppm             |       |              |
+------+------+---------------------------------+-------+--------------+
| **[T |      |                                 |       |              |
| OXIC |      |                                 |       |              |
| OLOG |      |                                 |       |              |
| Y]{. |      |                                 |       |              |
| unde |      |                                 |       |              |
| rlin |      |                                 |       |              |
| e}** |      |                                 |       |              |
+------+------+---------------------------------+-------+--------------+
| 870. | 81-1 | Acute Oral - Rat                | 2,    | 42814404 &   |
| 1100 |      |                                 | 3,4,5 | Open         |
|      |      |                                 |       | Literature   |
+------+------+---------------------------------+-------+--------------+
| 870. | 81-2 | Acute Dermal - Rabbit           | 2,    | waived       |
| 1200 |      |                                 | 3,4,5 |              |
+------+------+---------------------------------+-------+--------------+
| 870. | 81-3 | Acute Inhalation -- Rat         | 2,    | OTS 527779-2 |
| 1300 |      |                                 | 3,4,5 | (Nachreiner, |
|      |      |                                 |       | D.J., 1991)  |
+------+------+---------------------------------+-------+--------------+
| 870. | 81-4 | Acute Eye Irritation - Rabbit   | 2,    | 42814404     |
| 2400 |      |                                 | 3,4,5 |              |
+------+------+---------------------------------+-------+--------------+
| 870. | 81-5 | Acute Skin Irritation - Rabbit  | 2,    | 42814404     |
| 2500 |      |                                 | 3,4,5 |              |
+------+------+---------------------------------+-------+--------------+
| 870. | 81-6 | Dermal Sensitization            | 2,    | 42814404 &   |
| 2600 |      |                                 | 3,4,5 | Open         |
|      |      |                                 |       | Literature   |
+------+------+---------------------------------+-------+--------------+
| 870. | 8    | 90-Day Oral Subchronic -Rat     | 2,    | Open         |
| 3100 | 2-1a |                                 | 3,4,5 | Literature & |
|      |      |                                 |       | OTS          |
|      |      |                                 |       | 0527779-1    |
|      |      |                                 |       | (Union       |
|      |      |                                 |       | Carbide,     |
|      |      |                                 |       | 1989 and     |
|      |      |                                 |       | Union        |
|      |      |                                 |       | Carbide,     |
|      |      |                                 |       | 1990)        |
+------+------+---------------------------------+-------+--------------+
| 870. | 82   | 21-Day Subchronic Dermal        | 2,    | 42814404 &   |
| 3250 | -3\* |                                 | 3,4,5 | Open         |
|      |      |                                 |       | Literature   |
+------+------+---------------------------------+-------+--------------+
| 870. | 82   | 90-Day Subchronic Inhalation    | 2,    | OTS          |
| 3465 | -4\* |                                 | 3,4,5 | 0537563-1    |
|      |      |                                 |       | (Norris, J.  |
|      |      |                                 |       | and W.       |
|      |      |                                 |       | Kintigh,     |
|      |      |                                 |       | 1994 & Sun,  |
|      |      |                                 |       | J. and W.    |
|      |      |                                 |       | Kintigh,     |
|      |      |                                 |       | 1993)        |
+------+------+---------------------------------+-------+--------------+
| 870. | 8    | Chronic Toxicity - rat          | 2,    | satisfied by |
| 4100 | 3-1a |                                 | 3,4,5 | guideline    |
|      |      |                                 |       | 870.4300     |
+------+------+---------------------------------+-------+--------------+
| 870. | [8   | Chronic Toxicity - non-rodent   | 2,    | 42814404 &   |
| 4100 | 3-1b |                                 | 3,4,5 | Open         |
|      | ]{.m |                                 |       | Literature   |
|      | ark} |                                 |       |              |
+------+------+---------------------------------+-------+--------------+
| 870. | 83-5 | Combined Chronic                | 2,    | 42814404 &   |
| 4300 |      | Toxicity/Carcinogenicity - rat  | 3,4,5 | Open         |
|      |      |                                 |       | Literature   |
+------+------+---------------------------------+-------+--------------+
| 870. | 8    | Prenatal Developmental          | 2,    | 42814404 &   |
| 3700 | 3-3a | Toxicity - Rat                  | 3,4,5 | OTS          |
|      |      |                                 |       | 7527779-4    |
|      |      |                                 |       | (Union       |
|      |      |                                 |       | Carbide,     |
|      |      |                                 |       | 1991)        |
+------+------+---------------------------------+-------+--------------+
| 870. | 8    | Prenatal Developmental          | 2,    | 42814404     |
| 3700 | 3-3b | Toxicity - Rabbit               | 3,4,5 |              |
+------+------+---------------------------------+-------+--------------+
| 870. | [    | Reproduction and fertility      | 2,    | 42814404 &   |
| 3800 | 83-4 | effects - Rat                   | 3,4,5 | Open         |
|      | \*\* |                                 |       | Literature   |
|      | ]{.m |                                 |       |              |
|      | ark} |                                 |       |              |
+------+------+---------------------------------+-------+--------------+
| 870. | 84-2 | Bacterial Reverse Mutation Test | 2,    | OTS          |
| 5100 |      |                                 | 3,4,5 | 50527779-1   |
+------+------+---------------------------------+-------+--------------+
| 870. | 84-2 | In Vitro Mammalian Cell Gene    | 2,    | OTS          |
| 5300 |      | Aberration Test                 | 3,4,5 | 50527779-1   |
+------+------+---------------------------------+-------+--------------+
| 870. | 84-2 | In Vitro Mammalian Chromosome   | 2,    | OTS          |
| 5375 |      | Aberration Test                 | 3,4,5 | 50527779-1   |
+------+------+---------------------------------+-------+--------------+
| 870. | 84-2 | In Vitro Sister Chromatid       | 2,    | OTS          |
| 5900 |      | Exchange                        | 3,4,5 | 50527779-1   |
+------+------+---------------------------------+-------+--------------+
| 870. | 85-1 | Metabolism and Pharmocokinetics | 2,    | 42814404     |
| 7485 |      |                                 | 3,4,5 |              |
+------+------+---------------------------------+-------+--------------+
| \    |      |                                 |       |              |
| *For |      |                                 |       |              |
| gu   |      |                                 |       |              |
| idel |      |                                 |       |              |
| ines |      |                                 |       |              |
| 82-3 |      |                                 |       |              |
| and  |      |                                 |       |              |
| 8    |      |                                 |       |              |
| 2-4, |      |                                 |       |              |
| at   |      |                                 |       |              |
| l    |      |                                 |       |              |
| east |      |                                 |       |              |
| one  |      |                                 |       |              |
| is   |      |                                 |       |              |
| requ |      |                                 |       |              |
| ired |      |                                 |       |              |
| to   |      |                                 |       |              |
| be   |      |                                 |       |              |
| fu   |      |                                 |       |              |
| lfil |      |                                 |       |              |
| led; |      |                                 |       |              |
| not  |      |                                 |       |              |
| both |      |                                 |       |              |
| (for |      |                                 |       |              |
| both |      |                                 |       |              |
| food |      |                                 |       |              |
| and  |      |                                 |       |              |
| non- |      |                                 |       |              |
| food |      |                                 |       |              |
| us   |      |                                 |       |              |
| es). |      |                                 |       |              |
|      |      |                                 |       |              |
| [    |      |                                 |       |              |
| \*\* |      |                                 |       |              |
| Only |      |                                 |       |              |
| requ |      |                                 |       |              |
| ired |      |                                 |       |              |
| for  |      |                                 |       |              |
| food |      |                                 |       |              |
| use. |      |                                 |       |              |
| ]{.m |      |                                 |       |              |
| ark} |      |                                 |       |              |
+------+------+---------------------------------+-------+--------------+
| **[E |      |                                 |       |              |
| NVIR |      |                                 |       |              |
| ONME |      |                                 |       |              |
| NTAL |      |                                 |       |              |
| FAT  |      |                                 |       |              |
| E]{. |      |                                 |       |              |
| unde |      |                                 |       |              |
| rlin |      |                                 |       |              |
| e}** |      |                                 |       |              |
+------+------+---------------------------------+-------+--------------+
| 835. | 1    | Hydrolysis of Parent and        | 2,    | waived       |
| 2120 | 61-1 | Degradates                      | 3,4,5 |              |
+------+------+---------------------------------+-------+--------------+

> **Please Note:** Although the Open Literature studies do not satisfy
> any of the Agency\'s testing guideline requirements, this information
> is considered adequate for characterizing the potential hazard from
> exposure to triethylene glycol. Therefore, no additional mammalian
> toxicity data will be required at this time.

Number range CHAPTER**Appendix C: Technical Support Documents**

Additional documentation in support of this RED is maintained in the OPP
docket, located in Room 119, Crystal Mall #2, 1801 South Bell Street,
Arlington, VA 22202. It is open Monday through Friday, excluding legal
holidays, from 8:30 am to 4:00 pm.

All documents, in hard copy form, may be viewed in the OPP docket room
or downloaded or viewed via the Internet at the following site:
<http://www.epa.gov/edocket>

These documents include:

-   Triethylene Glycol (TEG): Antimicrobials Division\'s Review of the
    Disciplinary Sciences for Issuance of the Reregistration Eligibility
    Decision (RED) Document. Reregistration Case No.: 3146, PC
    Code: 083501. CAS Registry No.: 112-27-6

-   Triethylene Glycol- Revised Report of the Antimicrobials Division
    Toxicology Endpoint Selection Committee. PC Code 083501, Case 3146,
    Antimicrobials Division, 11/21/05,

    Timothy F. McMahon, Ph.D., Chair, ADTC

-   Product Chemistry Science Chapter. PC Code 083501, Case 3146,
    Antimicrobials Division, 8/13/03, A. Najm Shamim, Ph.D., Chemist

-   Environmental Fate Studies and Environmental Fate Assessment. PC
    Code 083501, Case 3146, Antimicrobials Division, 8/13/03, A. Najm
    Shamim, Ph.D.

-   Revised Toxicology Disciplinary Chapter. PC Code 083501, Case 3146,
    Antimicrobials Division, 10/11/05, Michelle Centra

-   [Occupational and Residential Exposure. PC Code 083501, Case No.
    3146, Antimicrobials Division, 5/24/05, Timothy Leighton,
    Environmental Scientist]{.mark}

    []{.mark}

-   Ecological Hazard and Environmental Risk Characterization. PC Code
    083501, Case 3146, Antimicrobials Division, 8/4/04, Kathryn
    Montague, M.S.

-   Review of Phase IV Response Submissions in Support of FIFRA 88.
    Memorandum: G. Reddy, 12/22/93

-   Number range CHAPTERTriethylene Glycol: Incident Report Assessment
    for the Reregistration Eligibility Decision (RED) Document. PC
    Code: 083501. Case No. 3146 (Memorandum: J. Chen, 9/22/03).

-   Number range CHAPTERTriethylene Glycol Estimated Drinking Water
    Concentrations (Memorandum: S. Abel, 9/26/03).

**Appendix D: Number range CHAPTERBibliography Citations**

**[MRID Number]{.underline} [Citation]{.underline}**

> 40228401 Mayer, F.L. (1986) Acute Toxicity Handbook of Chemicals to
> Estuarine Organisms. Prepared by U. S. EPA Office of Research and
> Development, Environmental Research Laboratory, Gulf Breeze, FLA
> EPA/600/X-36/231.
>
> 42211801 Reed, G. (1992) Product Chemistry Data: Ozium Glycolized Air
> Sanitizer. Unpublished study prepared by Blue Coral, Inc. 10 p.
>
> 42814404 Davis, K.(1993) Compilation of Toxicology Data References for
> Triethylene Glycol: Lab Project Number: TEGTOX. Unpublished study
> prepared by RegWest Co. 131 p.

[42814401]{.mark} Number range CHAPTER[Davis, K. (1993) Product
Chemistry Data of Triethylene Glycol: Lab Project Number: TEG61.
Unpublished study prepared by RegWest Co. 6 p.]{.mark}

42814402 Davis, K. (1993) Product Chemistry Data of Triethylene Glycol:
Lab Project Number: TEG62. Unpublished study prepared by RegWest Co. 13
p.

42814403 Davis, K. (1993) Physical & Chemical Characteristics of
Triethylene Glycol: Lab Project Number: TEG63. Unpublished study
prepared by RegWest Co. 91 p.

**[EPA ID Document Number]{.underline}**

OTS0527779-1 Guzzie, P., Slesinski, F. Frank, et al. (1986a) Triethylene
Glycol Salmonella/Microsome (Ames) Bacterial Mutagenicity Assay. Bushy
Run Research Center, Export, PA. Project Report 49-58. April 29, 1986.
NTIS Report No. OTS0527779-1. Unpublished.

> OTS0527779-1 Guzzie, P., Slesinski, F. Frank, et al. (1986b)
> Triethylene Glycol: *In vitro* Chromosome Aberration Study. Bushy Run
> Research Center, Export, PA. Project Report 49-82. July 1, 1986. NTIS
> Report No. OTS0527779-1. Unpublished.

OTS0527779-1 Slensinski, R., F. Frank, and P. Guzzie (1986a) Triethylene
Glycol: *In vitro* Genotoxicity Studies: CHO/HGPRT Mutation Test; Sister
Chromatid Exchange Assay. Bushy Run Research Center, Export, PA. Project
Report 49-83. June 26, 1986. NTIS Report No. OTS0527779-1. Unpublished.

> OTS0527779-1 Slensinski, R., F. Frank, and P. Guzzie (1986b)
> Triethylene Glycol: *In vitro* Mammalian Cell Gene Mutation Assay in
> CHO Cells. Bushy Run Research Center, Export, PA. Project Report
> 49-82. June 26, 1986. NTIS Report No. OTS0527779-1. Unpublished.

OTS0527779-1 Union Carbide (1989) Triethylene Glycol: Fourteen-day
Dietary Toxicity Study in Fischer 344 Rats. NTIS Report No.
OTS0527779-1. Unpublished.

> OTS0527779-1 Union Carbide (1990a) Triethylene Glycol: Ninety-day
> Dietary Toxicity Study in Fischer 344 Rats. NTIS Report No.
> OTS0527779-1. Unpublished.
>
> OTS0527779-1 Union Carbide (1990b) Developmental Toxicity Study of
> Triethylene Glycol Administered by Gavage to CD-1 Mice. NTIS Report
> No. OTS0527779-1. Unpublished.
>
> OTS0527779-2 Nachreiner, D.J. (1991) Triethylene Glycol (TEG) Acute
> Aerosol Inhalation Toxicity Test in Rats. Bushy Run Research Center;
> Project Report 53-139 (BRCC No. 90-22-40272), March 4, 1991; NTIS
> Report No. OTS0527779-2. Unpublished.

OTS0527779-4 Union Carbide (1991) Developmental Toxicity Study of
Triethylene Glycol Administered by Gavage to CD (Sprague-Dawley) Rats.
NTIS Report No. OTS0527779-4. Unpublished.

OTS0537563-1 Norris, J. and W. Kintigh (1994) Triethylene Glycol:
Nine-day Aerosol Inhalation (Nose-only Exposure) toxicity study in Rats.
Bushy Run Research Center, Union Carbide Corporation, Inc., Export, PA.
Laboratory Project ID: 93U1293, October 26, 1994. NTIS Report No.
OTS0537563-1. Unpublished.

OTS0537563-1 Sun, J. and W. Kintigh (1992) Triethylene Glycol: Nine-day
Aerosol Inhalation study in Rats. Bushy Run Research Center, Union
Carbide Chemicals and Plastics Company, Inc., Export, PA. Laboratory
Project ID: 91U0027, December 14, 1992. NTIS Report No. OTS0537563-1
with cover letter dated 010693 (1992). Unpublished.

**[Open Literature Citations]{.underline}**

> Bossert, N.L., et al. (1992) Reproductive Toxicity of Triethylene
> Glycol and its Diacetate and Dimethyl ether Derivatives in a
> Continuous Breeding Protocol in Swiss CD-1 mice. Fund. Appl.
> Pharmacol. 18: 602-608.
>
> Budavari, S., M.J. O'Neill, A. Smith, and P.E. Heckelman (eds.)1989.
> The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals.
> Rahway (eleventh edition), NJ: Merck & Co., Inc.
>
> Clayton, G.D. and F.E. Clayton (eds.). [Patty's Industrial Hygiene and
> Toxicology]{.underline}: Volume 2A, 2B, 2C: Toxicology. 3^rd^ ed. New
> York: John Wiley Sons, 1981-1982. 3839.
>
> Fitzhugh, O.G. and Nelson, A.A. (1946) Comparison of the Chronic
> Toxicity of Triethylene Glycol with that of Diethylene Glycol. J. Ind.
> Hyg. Toxicol. 28(2): 40-43.
>
> Geiger, D.L., Call, D.J., and Brooke, L.T. (Eds). 1988. [Acute
> Toxicities of Organic Chemicals to Fathead]{.underline} [Minnows
> (Pimephales promelas). Vol. IV.]{.underline} Superior Wisconsin:
> University of Wisconsin-Superior. 131.
>
> Goldstein, I., et al. (1970) Toxicity of Glycol Derivatives. Igenia,
> 19: 209.
>
> Guillot, J.P., et al. (1982) Safety Evaluation of Some Humectants and
> Moisturizers Used in Cosmetic Formulations. International J. Cosmetic
> Sci., 4: 67.
>
> [Handbook of Environmental Fate]{.underline}; Fate and Exposure Data
> For Organic Chemicals, Volume IV, Solvents 2. Philip H. Howard, Lewis
> Publishers, 1989, pp 546.
>
> [Handbook of Physics and Chemistry,]{.underline} 64^th^ edition (CRC
> Press). Product Chemistry Data for Triethylene Glycol, 1983.
>
> Hazard Substances Databank (HSDB), A Database of the National Library
> of Medicine's TOXNET System; Product Chemistry Data for Triethylene
> Glycol, 2003.
>
> Lamb, I.V. et al. (1997) Triethylene Glycol. Environ. Health
> Perspectives, 105(Suppl 1): 235-236. Also available as an NTP Report
> No. PB85-137073.
>
> Number range CHAPTERLauter, W.M. and V.L. Vria (1940) Toxicity of
> Triethylene Glycol and the Effect of Para-amino-benzene Sulfonamide
> Upon the Toxicity of this Glycol. J. Am. Pharmaceutical Assoc. 29:
> 5-8.

Pharmaceutical Assoc. 29: 5-8.

> McKennis, Jr., et al. (1962) The Excretion and Metabolism of
> Triethylene Glycol. Toxic. Appl. Pharmacol., 91: 52.
>
> Robertson, O.H., et al. (1947) Tests for the Chronic Toxicity of
> Propylene Glycol and Triethylene Glycol on Monkeys and Rats by vapor
> inhalation and Oral Administration. J. Pharm. Exp. Ther., 91: 52.
>
> Smyth, H.F. et al (1941) The single dose toxicity of some glycol
> derivatives. J. Ind. Hyg. Toxicol. 23(6): 259-268.
>
> Stenger, E.G., er al. (1968) Zur Toxikologie des Triathylenglkol.
> Arzneimittel-Forsch, 18: 1536.
>
> Verschuren, K. 1983. [Handbook of Environmental Data of Organic
> Chemicals. 2^nd^ ed.]{.underline} New York, NY: Van Nostrand Reinhold
> Co. 1153.

**[Supporting Documentation]{.underline}**

> NIH. 2003. NIH's Hazard Substances Databank (HSDB), A Database of the
> National Library of Medicine's TOXNET System.
> <http://www.nih.gov/TOXNET>
>
> USEPA. 1997. Pesticide Handler Exposure Database (PHED, Version 1.1),
> Surrogate
>
> Exposure Guide; Estimates of Worker Exposure, May 1997.
>
> USEPA. 1999. Evaluation of Chemical Manufacturers Association
> Antimicrobial Exposure Assessment Study. Memorandum from Siroos
> Mostaghimi, Ph.D., to Julie Fairfax; dated November 4, 1999.
>
> USEPA. 2003. Estimation of Physical/Chemical Properties Program.
> <http://www.epa.gov/oppt/exposure/docs/episuitedl.htm>
>
> USEPA. 2004. Overview of the Ecological Risk Assessment Process in the
> Office of Pesticide Programs U.S. Environmental Protection Agency -
> Endangered and Threatened Species Effects Determinations, January 24,
> 04, Appendix A, Section IIB, pg.81.
> <http://www.epa.gov/oppfead1/endanger/consultation/ecorisk-overview.pdf>

Number range CHAPTER**Appendix E: Generic Data Call-In**

The Agency does not intend to issue a Generic Data Call-In at this time.

Number range CHAPTER**Appendix F: Product Specific Data Call-In**

The Agency intends to issue a Product Specific Data Call-In at a later
date.

**Number range CHAPTERAppendix G: Batching of End-Use Products**

**Antimicrobial Division\'s Batching of Products Containing Triethylene
Glycol as the Active Ingredient for Meeting Acute Toxicity Data
Requirements for Reregistration**

In an effort to reduce the time, resources and number of animals needed
to fulfill the acute toxicity data requirements for reregistration of
products containing the active ingredient triethylene glycol, the Agency
has batched products which can be considered similar in terms of acute
toxicity. (The PC Code of triethylene glycol is 083501; the CAS Number
is 112-27-6.) Factors considered in the sorting process include each
product\'s active and inert ingredients (identity, percent composition
and biological activity), product form (liquid, paste, solid, etc.),
labeling (e.g., signal word, precautionary labeling, etc.) and acute
toxicity data.

Using available information, batching has been accomplished by the
process described in the preceding paragraph. Notwith­standing the
batching process, the Agency reserves the right to require, at any time,
acute toxicity data for an individual product should the need arise.

Registrants of products within a batch may choose to cooperatively
generate, submit or cite a single set of six acute toxicity studies to
represent all the products within that batch. Registrants have the
option of participating with all or some other registrants of products
in their product's batch, to deal only their own products within a
batch, or to generate all the required acute toxicological studies for
each of their own products. [If a registrant chooses to generate the
data for a batch, he or she must use one of the products within the
batch as the test material.]{.underline} If a registrant chooses to rely
upon previously submitted acute toxicity data, he or she may do so
provided that the data base is complete and valid by today\'s standards
(see the attached acceptance criteria), the formulation tested is
considered by EPA to be similar in terms of acute toxicity, and the
formulation has not been significantly altered since submission and
acceptance of the acute toxicity data. [Registrants may not support
their product using data conducted on a product from a different batch,
unless this batching appendix specifically states so.]{.underline} [The
Antimicrobials Division must approve any new or canceled formulations
(that were presented to the Agency after the publication of the RED)
before data derived from them can be used to cover other products in a
batch.]{.underline} [Regardless of whether new data is generated or
existing data is referenced, registrants must clearly identify the test
material by EPA Registration Number.]{.underline} If more than one
confidential statement of formula (CSF) exists for a product, the
registrant must indicate the formulation actually tested by identifying
the corresponding CSF.

In deciding how to meet the product specific data requirements,
registrants must follow the directions given in the Data Call-In (DCI)
Notice and its attachments appended to the RED. The DCI Notice contains
two response forms which are to be completed and submitted to the Agency
within 90 days of receipt. The first form, \"Data Call-In Response,\"
asks whether the registrant will meet the data requirements for each
product. The second form, \"Requirements Status and Registrant\'s
Response,\" lists the product specific data required for each product,
including the standard six acute toxicity tests. A registrant who wishes
to participate in a batch must decide whether he or she will provide the
data or depend on someone else to do so. If a registrant supplies the
data to support a batch of products, he or she must select one of the
following options: Developing New Data (Option 1), Submitting an
Existing Study (Option 4), Upgrading an Existing Study (Option 5) or
Citing an Existing Study (Option 6). If a registrant depends on
another\'s data, he or she must choose among: Cost Sharing (Option 2),
Offers to Cost Share (Option 3) or Citing an Existing Study (Option 6).
If a registrant does not want to participate in a batch, the choices are
Options 1, 4, 5 or 6. However, a registrant should know that choosing
not to participate in a batch does not preclude other registrants in the
batch from citing his or her studies and offering to cost share (Option
3) those studies.

If a registrant would like to have the batching status of a product
reconsidered, they need to submit detailed information on their product,
including a detailed rationale for the inclusion of their product into a
batch. An MSDS for each "inert" ingredient should be included where
possible. However, registrants and manufacturers should realize that the
more unique their formulation is, the less likely it is to be able to
batch that product. AD/PSB notes that there were no registered Technical
Grade Active Ingredient (TGAI) products to be reviewed in this batching
chapter.

Table 1 displays the batch for the active ingredient Triethylene Glycol.

Table 1.

+-------+-------------+------------------------------------------------+
| Batch | R           | Percent Active Ingredient                      |
|       | egistration |                                                |
|       |             |                                                |
|       | Number      |                                                |
+-------+-------------+------------------------------------------------+
| 1     | 51838-1     | Triethylene Glycol \... 4.4%                   |
|       |             |                                                |
|       |             | Propylene Glycol \... 4.4%                     |
+-------+-------------+------------------------------------------------+
|       | 51838-2     | Triethylene Glycol \... 4.4%                   |
|       |             |                                                |
|       |             | Propylene Glycol \... 4.4%                     |
+-------+-------------+------------------------------------------------+
| 2     | 4822-293    | Triethylene Glycol \... 6.0%                   |
+-------+-------------+------------------------------------------------+
|       | 4822-531    | Triethylene Glycol \... 6.0%                   |
+-------+-------------+------------------------------------------------+

Table 2 lists the products in the "No Batch" group. These products can
not be batched because they were not considered to be similar to other
the products in terms of acute toxicity or because there was
insufficient information available to assist in making the decision.

Table 2. The "No Batch Group" of Products Containing Triethylene Glycol
as an Active Ingredient

+----------------+-----------------------------------------------------+
| Registration   | Percent Active Ingredient                           |
| Number         |                                                     |
+----------------+-----------------------------------------------------+
| 9444-19        | Triethylene Glycol \... 6.000%                      |
|                |                                                     |
|                | Dipropylene Glycol \... 4.000%                      |
|                |                                                     |
|                | n-Alkyl dimethyl benzyl ammonium chloride \...      |
|                | 0.20%                                               |
+----------------+-----------------------------------------------------+
| 9444-136       | Triethylene Glycol \... 9.15%                       |
|                |                                                     |
|                | Dipropylene Glycol \... 3.43%                       |
|                |                                                     |
|                | n-Alkyl dimethyl benzyl ammonium chloride \...      |
|                | 0.17%                                               |
+----------------+-----------------------------------------------------+
| 10807-24       | Triethylene Glycol \... 4.5%                        |
|                |                                                     |
|                | Propylene Glycol \... 3.0%                          |
|                |                                                     |
|                | n-Alkyl dimethyl benzyl ammonium chloride \...      |
|                | 0.10%                                               |
+----------------+-----------------------------------------------------+
| 10807-37       | Triethylene Glycol \... 3.00%                       |
|                |                                                     |
|                | Dipropylene Glycol \... 3.00%                       |
|                |                                                     |
|                | n-Alkyl dimethyl benzyl ammonium chloride \...      |
|                | 0.10%                                               |
|                |                                                     |
|                | n-Alkyl dimethyl ethylbenzyl ammonium chloride \... |
|                | 0.10%                                               |
+----------------+-----------------------------------------------------+
| 10807-43       | Triethylene Glycol \... 7.7%                        |
|                |                                                     |
|                | Propylene Glycol \... 5.13%                         |
|                |                                                     |
|                | n-Alkyl dimethyl benzyl ammonium chloride \...      |
|                | 0.17%                                               |
+----------------+-----------------------------------------------------+
| 11715-20       | Triethylene Glycol \... 0.10%                       |
|                |                                                     |
|                | Propylene Glycol \... 0.10%                         |
|                |                                                     |
|                | Pyrethrins \... 0.09%                               |
|                |                                                     |
|                | Piperonyl butoxide \... 0.18%                       |
|                |                                                     |
|                | n-Octyl bicycloheptene dicarboximide \... 0.30%     |
+----------------+-----------------------------------------------------+
| 44446-20       | Triethylene Glycol \... 6.00%                       |
|                |                                                     |
|                | n-Alkyl dimethyl ammonium chloride \... 0.10%       |
|                |                                                     |
|                | n-Alkyl dimethyl ethylbenzyl ammonium chloride \... |
|                | 0.10%                                               |
|                |                                                     |
|                | Isopropanol \... 50.20%                             |
+----------------+-----------------------------------------------------+

Number range CHAPTER**Appendix H: List of All Registrants Sent the Data
Call-In**

A list of registrants sent the data call-in will be posted at a later
date.

Number range CHAPTER**Appendix I: List of Available Forms**

Pesticide Registration Forms are available at the following EPA internet
site:

[[http://www.epa.gov/opprd001/forms/]{.underline}](http://www.epa.gov/opprd001/forms/)

Pesticide Registration Forms (These forms are in PDF format and require
the Acrobat reader)

**Instructions**

> 1\. Print out and complete the forms. (Note: Form numbers that are
> bolded can be filled out on your computer then printed.)
>
> 2\. The completed form(s) should be submitted in hardcopy in accord
> with the existing policy.
>
> 3\. Mail the forms, along with any additional documents necessary to
> comply with EPA regulations covering your request, to the address
> below for the Document Processing Desk.

DO NOT fax or e-mail any form containing \'Confidential Business
Information\' or \'Sensitive Information.\'

If you have any problems accessing these forms, please contact Nicole
Williams at (703) 308-5551 or by e-mail at
[[williams.nicole@epa.gov.]{.underline}](mailto:williams.nicole@epa.gov.)

The following Agency Pesticide Registration Forms are currently
available via the internet at the following locations:

+----------+--------------------------------+--------------------------+
| 8570-1   | Application for Pesticide      | [[http://w               |
|          |                                | ww.epa.gov/opprd001/form |
|          | Registration/Amendment         | s/8570-1.pdf]{.underline |
|          |                                | }](http://www.epa.gov/op |
|          |                                | prd001/forms/8570-1.pdf) |
+----------+--------------------------------+--------------------------+
| 8570-4   | Confidential Statement of      | [[http://w               |
|          | Formula                        | ww.epa.gov/opprd001/form |
|          |                                | s/8570-4.pdf]{.underline |
|          |                                | }](http://www.epa.gov/op |
|          |                                | prd001/forms/8570-4.pdf) |
+----------+--------------------------------+--------------------------+
| 8570-5   | Notice of Supplemental         | [[http://w               |
|          | Registration of                | ww.epa.gov/opprd001/form |
|          |                                | s/8570-5.pdf]{.underline |
|          | Distribution of a Registered   | }](http://www.epa.gov/op |
|          | Pesticide                      | prd001/forms/8570-5.pdf) |
|          |                                |                          |
|          | Product                        |                          |
+----------+--------------------------------+--------------------------+
| 8570-17  | Application for an             | [[http://www             |
|          | Experimental Use               | .epa.gov/opprd001/forms/ |
|          |                                | 8570-17.pdf]{.underline} |
|          | Permit                         | ](http://www.epa.gov/opp |
|          |                                | rd001/forms/8570-17.pdf) |
+----------+--------------------------------+--------------------------+
| 8570-25  | Application for/Notification   | [[http://www             |
|          | of State                       | .epa.gov/opprd001/forms/ |
|          |                                | 8570-25.pdf]{.underline} |
|          | Registration of a Pesticide To | ](http://www.epa.gov/opp |
|          | Meet a                         | rd001/forms/8570-25.pdf) |
|          |                                |                          |
|          | Special Local Need             |                          |
+----------+--------------------------------+--------------------------+
| 8570-27  | Formulator\'s Exemption        | [[http://www             |
|          | Statement                      | .epa.gov/opprd001/forms/ |
|          |                                | 8570-27.pdf]{.underline} |
|          |                                | ](http://www.epa.gov/opp |
|          |                                | rd001/forms/8570-27.pdf) |
+----------+--------------------------------+--------------------------+
| 8570-28  | Certification of Compliance    | [[http://www             |
|          | with Data Gap Procedures       | .epa.gov/opprd001/forms/ |
|          |                                | 8570-28.pdf]{.underline} |
|          |                                | ](http://www.epa.gov/opp |
|          |                                | rd001/forms/8570-28.pdf) |
+----------+--------------------------------+--------------------------+
| 8570-30  | Pesticide Registration         | [[http://www             |
|          | Maintenance Fee                | .epa.gov/opprd001/forms/ |
|          |                                | 8570-30.pdf]{.underline} |
|          | Filing                         | ](http://www.epa.gov/opp |
|          |                                | rd001/forms/8570-30.pdf) |
+----------+--------------------------------+--------------------------+
| 8570-32  | Certification of Attempt to    | [[http://www             |
|          | Enter into an                  | .epa.gov/opprd001/forms/ |
|          |                                | 8570-32.pdf]{.underline} |
|          | Agreement with other           | ](http://www.epa.gov/opp |
|          | Registrants for                | rd001/forms/8570-32.pdf) |
|          |                                |                          |
|          | Development of Data            |                          |
+----------+--------------------------------+--------------------------+
| 8570-34  | Certification with Respect to  | [[http://www.epa.gov     |
|          | Citations of Data (PR Notice   | /opppmsd1/PR_Notices/pr9 |
|          | 98-5)                          | 8-5.pdf]{.underline}](ht |
|          |                                | tp://www.epa.gov/opppmsd |
|          |                                | 1/PR_Notices/pr98-5.pdf) |
+----------+--------------------------------+--------------------------+
| 8570-35  | Data Matrix (PR Notice 98-5)   | [[http://www.epa.gov     |
|          |                                | /opppmsd1/PR_Notices/pr9 |
|          |                                | 8-5.pdf]{.underline}](ht |
|          |                                | tp://www.epa.gov/opppmsd |
|          |                                | 1/PR_Notices/pr98-5.pdf) |
+----------+--------------------------------+--------------------------+
| 8570-36  | Summary of the                 | [[http://www.epa.gov     |
|          | Physical/Chemical              | /opppmsd1/PR_Notices/pr9 |
|          |                                | 8-1.pdf]{.underline}](ht |
|          | Properties (PR Notice 98-1)    | tp://www.epa.gov/opppmsd |
|          |                                | 1/PR_Notices/pr98-1.pdf) |
+----------+--------------------------------+--------------------------+
| 8570-37  | Self-Certification Statement   | [[http://www.epa.gov     |
|          | for the                        | /opppmsd1/PR_Notices/pr9 |
|          |                                | 8-1.pdf]{.underline}](ht |
|          | Physical/Chemical Properties   | tp://www.epa.gov/opppmsd |
|          | (PR Notice 98-1)               | 1/PR_Notices/pr98-1.pdf) |
+----------+--------------------------------+--------------------------+

**Pesticide Registration Kit**
[[www.epa.gov/pesticides/registrationkit/]{.underline}](http://www.epa.gov/)

Dear Registrant:

For your convenience, we have assembled an online registration kit which
contains the following pertinent forms and information needed to
register a pesticide product with the U.S. Environmental Protection
Agency\'s Office of Pesticide Programs (OPP):

> 1\. The Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA)
> and the Federal Food, Drug and Cosmetic Act (FFDCA) as Amended by the
> Food Quality Protection Act (FQPA) of 1996.

2\. Pesticide Registration (PR) Notices

> a\. 83-3 Label Improvement Program\--Storage and Disposal Statements

b\. 84-1 Clarification of Label Improvement Program

c\. 86-5 Standard Format for Data Submitted under FIFRA

> d\. 87-1 Label Improvement Program for Pesticides Applied through
> Irrigation Systems (Chemigation)

e\. 87-6 Inert Ingredients in Pesticide Products Policy Statement

f\. 90-1 Inert Ingredients in Pesticide Products; Revised Policy
Statement

g\. 95-2 Notifications, Non-notifications, and Minor Formulation
Amendments

> h\. 98-1 Self Certification of Product Chemistry Data with Attachments
> (This document is in PDF format and requires the Acrobat reader.)

Other PR Notices can be found at
[[http://www.epa.gov/opppmsd1/PR_Notices]{.underline}](http://www.epa.gov/opppmsd1/PR_Notices)

> 3\. Pesticide Product Registration Application Forms (These forms are
> in PDF format and will require the Acrobat reader).

a\. EPA Form No. 8570-1, Application for Pesticide
Registration/Amendment

b\. EPA Form No. 8570-4, Confidential Statement of Formula

c\. EPA Form No. 8570-27, Formulator\'s Exemption Statement

d\. EPA Form No. 8570-34, Certification with Respect to Citations of
Data

e\. EPA Form No. 8570-35, Data Matrix

> 4\. General Pesticide Information (Some of these forms are in PDF
> format and will require the Acrobat reader).

a\. Registration Division Personnel Contact List

b\. Biopesticides and Pollution Prevention Division (BPPD) Contacts

c\. Antimicrobials Division Organizational Structure/Contact List

> d\. 53 F.R. 15952, Pesticide Registration Procedures; Pesticide Data
> Requirements (PDF format)
>
> e\. 40 CFR Part 156, Labeling Requirements for Pesticides and Devices
> (PDF format)

f\. 40 CFR Part 158, Data Requirements for Registration (PDF format)

g\. 50 F.R. 48833, Disclosure of Reviews of Pesticide Data (November 27,
1985)

Before submitting your application for registration, you may wish to
consult some additional sources of information. These include:

1\. The Office of Pesticide Programs\' website.

> 2\. The booklet \"General Information on Applying for Registration of
> Pesticides in the United States\", PB92-221811, available through the
> National Technical Information Service (NTIS) at the following
> address:

National Technical Information Service (NTIS)

5285 Port Royal Road

Springfield, VA 22161

The telephone number for NTIS is (703) 605-6000.

> 3\. The National Pesticide Information Retrieval System (NPIRS) of
> Purdue University\'s Center for Environmental and Regulatory
> Information Systems. This service does charge a fee for subscriptions
> and custom searches. You can contact NPIRS by telephone at (765)
> 494-6614 or through their website.
>
> 4\. The National Pesticide Telecommunications Network (NPTN) can
> provide information on active ingredients, uses, toxicology, and
> chemistry of pesticides. You can contact NPTN by telephone at (800)
> 858-7378 or through their website:
> [[http://npic.orst.edu/]{.underline}](http://npic.orst.edu/)

The Agency will return a notice of receipt of an application for
registration or amended registration, experimental use permit, or
amendment to a petition if the applicant or petitioner encloses with his
submission a stamped, self-addressed postcard. The postcard must contain
the following entries to be completed by OPP:

1\. Date of receipt;

2\. EPA identifying number; and

3\. Product Manager assignment.

Other identifying information may be included by the applicant to link
the acknowledgment of receipt to the specific application submitted. EPA
will stamp the date of receipt and provide the EPA identifying file
symbol or petition number for the new submission. The identifying number
should be used whenever you contact the Agency concerning an application
for registration, experimental use permit, or tolerance petition.

To assist us in ensuring that all data you have submitted for the
chemical are properly coded and assigned to your company, please include
a list of all synonyms, common and trade names, company experimental
codes, and other names which identify the chemical (including \"blind\"
codes used when a sample was submitted for testing by commercial or
academic facilities). Please provide a chemical abstract system (CAS)
number if one has been assigned.