# **NCI Summer Curriculum in**

# **Cancer Prevention**

**\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\***

**Molecular Prevention Course**

### **August 4 through 8, 2008**

**6001 Executive Boulevard**

**Conference Rooms C and D**

### **Rockville, Maryland 20852**

**301-435-1465**

#### PRELIMINARY 

#### Course Syllabus

**2008**

### *U.S. Department of Health and Human Services*

*National Institutes of Health*

### *National Cancer Institute*

####### Office of Preventive Oncology 

# NCI Summer Curriculum in Cancer Prevention

## Molecular Prevention Course

Date: August 4 through 8, 2008

Time: 8:30 a.m. to 10:00 a.m.

10:30 a.m. to 12:00 noon

1:00 p.m. to 2:30 p.m.

(occasionally, lecture times will vary)

Each session has a different topic and speaker

Location: 6001 Executive Boulevard

Conference Rooms C and D

Rockville, Maryland 20852

301-435-1465

Course presented by:

Office of Preventive Oncology Jonathan Wiest, PhD, Acting Director

National Cancer Institute Jackie Lavigne, PhD, MPH, Associate Director

National Institutes of Health Trishna Dey, Program Specialist

EPS, Suite T-41 Blanca Bonilla, Program Assistant

6120 Executive Boulevard Ellen Jaffe, Secretary

Bethesda, Maryland 20892 Jonelle C. Saunders, Summer InternTelephone:
301-496-8640

Fax: 301-480-2669

http://cancer.gov/prevention/pob

**Educational Objective For Molecular Prevention Course**

The overall objective of the course is to provide specialized
instruction in principles of molecular biology as applied in the field
of cancer prevention. The course focuses on the concepts, methods,
issues, and applications of molecular biology in cancer prevention
efforts and genetics of cancer. Participants will have an opportunity to
gain a broad-based perspective of these subject areas, including basic
laboratory methodology and theory of how molecular techniques are
applied to molecular epidemiology, bionutrition, chemoprevention,
biomarkers, and translational research. Life-long learning skills
include critical appraisal of molecular approaches, methodologies, and
theories used in the field of cancer prevention.

After attending this activity participants will be able to: outline and
apply the principles of molecular biology in cancer prevention; describe
the concepts and methods of molecular biology in the field of genetics
of cancer; demonstrate theoretical knowledge of basic laboratory
methodology and identify techniques in the areas of molecular
epidemiology, bionutrition, chemoprevention, biomarkers, and
translational research; discuss the process of translating laboratory
research in cancer prevention; and interpret methodologies and theories
used in the field of cancer prevention.

The target audiences are MD and PhD degree holders who also hold an MPH
degree, and were selected into the Cancer Prevention Fellowship Program,
and MD and PhD degree holders with an interest in cancer prevention and
control from the NIH and the NCI, national organizations, and foreign
institutions.

If you have a disability and require any assistive devices, services, or
other reasonable accommodations to participate in this activity, please
contact the Office of Preventive Oncology at 301-496-8640 at least 1
week in advance of the lecture date to discuss your needs.

NCI Summer Curriculum in Cancer Prevention and Control

Molecular Prevention Course

**Monday, August 4, 2008**

8:30 a.m. - 8:45 a.m. Introduction/Course Overview

8:45 a.m. - 10:30 a.m. Overview of Carcinogenesis Norman Hord, PhD, MPH,
RD

Break

11:00 a.m. - 12:30 p.m. Oncogenes, Tumor Suppressor Genes, and Goli
Samimi, PhD, MPH

Other Cancer-Related Genes

12:30 Group Photo

Lunch

1:30 p.m. - 3:00 p.m. Microarray Approaches in Cancer Prevention Jackie
Lavigne, PhD, MPH

### **Tuesday, August 5, 2008**

8:30 a.m. - 10:00 a.m. Cancer from a Biosystem Perspective J. Carl
Barrett, PhD

Break

10:30 a.m. - 12:00 noon The Immune System as a Target for Vaccine Connie
Rogers, PhD, MPH

> and Prevention Approaches

Lunch

1:00 p.m. - 2:30 p.m. Public Health Genomics: Closing the Gap Between
Muin J. Khoury, MD, PhD

Gene Discoveries and Cancer Control and Prevention

### **Wednesday, August 6, 2008**

8:30 a.m. - 10:00 a.m. Xenobiotic Metabolism and Cancer Susceptibility
Thomas Kensler, PhD

Break

10:30 a.m. - 12:00 noon Hormonal Carcinogenesis James D. Yager, PhD

Lunch

1:00 p.m. - 2:30 p.m. The Role of Inflammation in Cancer Curtis Harris,
MD

**[Thursday, August 7, 2008]{.underline}**

8:30 a.m. - 10:00 a.m. Understanding the Role of Barbara Dunn, MD, PhD

Epigenetics for Cancer Prevention

Break

10:30 a.m. - 12:00 noon Stem Cells and Cancer Barbara Vonderhaar, PhD

Lunch

1:00 p.m. - 2:30 p.m. Animal Models in Cancer Control Research Ron
Carsten, DVM, MS

### **Friday, August 8, 2008**

9:00 a.m. - 10:30 a.m. Biomedical Informatics for Molecular Kenneth
Buetow, PhD

Prevention Studies

Break

11:00 a.m. - 12:30 p.m. The Integration of Molecular Markers Into
Nathaniel Rothman, MD,

> Population Studies MPH, MHS

Faculty

Carl Barrett, PhD -- *Cancer From a Biosystem Perspective*

> Director, Novartis Institutes for Biomedical Research, 250
> Massachusetts Ave., Suite 3A-203, Cambridge, MA 02139; 617-871-3700;
> carl.barrett@novartis.com

**Kenneth H. Buetow, PhD** --- *Biomedical Informatics for Molecular
Prevention Studies*

Laboratory Chief, Laboratory of Population Genetics, NCI, NIH, Building
41, D702, 41 Center Dr, Bethesda, MD 20892-5060; 301-435-1520;
<buetowke@mail.nih.gov>

**Ron Carsten, DVM, MS** --- *Animal Models in Cancer Control Research*

> Animal Cancer Center, Colorado State University, 300 West Drake Road,
> Fort Collins CO 80523-1620; 970-491-0570; Ron.Carsten@ColoState.EDU

**Barbara Dunn, MD, PhD** --- *Understanding the Role of Genetics and
Epigenetics for Cancer Prevention*

Division of Cancer Prevention, NCI, NIH, Executive Plaza North, Room
321, MSC 7361, 6130 Executive Boulevard, Bethesda, MD 20892-7361;
301-496-8640; dunnb@mail.nih.gov

**Curtis Harris, MD** --- *The Role of Inflammation in Cancer*

> Laboratory Chief, Laboratory of Human Carcinogenesis, Head, Molecular
> Genetics and Carcinogenesis Section, Center for Cancer Research, NCI,
> NIH, Building 37, Room 3068A, Bethesda, MD 20892; 301-496-2048;
> curtis_harris@nih.gov

**Norman Hord, PhD, MPH, RD** --- *Overview of Carcinogenesis*

Assistant Professor, Department of Food Science and Human Nutrition,
Michigan State University,

208C Trout Food Science and Human Nutrition Building, East Lansing, MI
48824; 517-355-7713 x186; hord@msu.edu

Thomas Kensler, PhD -- *Xenobiotic Metabolism and Cancer Susceptibility*

> Professor, Department of Environmental Health Sciences, Division of
> Toxicology, The Johns Hopkins University Bloomberg School of Public
> Health, 615 N. Wolfe Street, Rm. E 7541, Baltimore, MD 21205;
> 410-955-4712; [**tkensler@jhsph.edu**](mailto:tkensler@jhsph.edu)

**Muin J. Khoury, MD, PhD** -- *Public Health Genomics: Closing the Gap
Between Gene Discoveries and Cancer Control and Prevention*

> Director, National Office of Public Health Genomics, Centers for
> Disease Control and Prevention, 4770 Buford Hwy, MS k89, Atlanta GA
> 30341; 770-488-8510; [**muk1@CDC.GOV**](mailto:tkensler@jhsph.edu)

**Jackie A. Lavigne, PhD, MPH** ---*Microarray Approaches in Cancer
Prevention*

Chief, Office of Education, Division of Cancer Epidemiology and
Genetics, NCI, NIH, Executive Plaza South, Room T-41, 6120 Executive
Boulevard, Bethesda, MD 20892-7361; 301-496-8640; lavignej@mail.nih.gov

**Connie Rogers, PhD, MPH** -- *The Immune System as a Target for
Vaccine* *and Prevention Approaches*

> Research Fellow, Laboratory of Tumor Immunology and Biology, Center
> for Cancer Research, NCI, NIH, Building 10, Room 8B04, 10 Center
> Drive, Bethesda, MD 20892-1750; 301-451-1417;
> [**rogersco@mail.nih.gov**](mailto:greinerj@mail.nih.gov)

**Nathaniel Rothman, MD, MPH, MHS** -- *The Integration of Molecular
Markers Into Population Studies*

> Senior Investigator, Occupational Epidemiology Branch, Division of
> Cancer Epidemiology and Genetics, National Cancer Institute, National
> Institutes of Health, Executive Plaza South, Room 8116, 6120 Executive
> Boulevard, Bethesda, MD 20892; 301-496-9093;
> [**rothmann@mail.nih.gov**](mailto:rothmann@mail.nih.gov)

**Goli Samimi, PhD, MPH** **--** *Oncogenes, Tumor Suppressor Genes, and
Other Cancer-Related Genes*

> Fellow, Cell and Cancer Biology Branch, Molecular Mechanisms Section,
> Center for Cancer Research, NCI, NIH, Building 37, Room 1130, 37
> Convent Drive, Bethesda, MD 20892; 301-443-2592;
> [samimig@mail.nih.gov](mailto:birrerm@bprb.nci.nih.gov)

**Barbara Vonderhaar, PhD, MPH** -- *Stem Cells and Cancer*

> Chief, Mammary Biology and Tumorigenesis Laboratory, Center for Cancer
> Research, NCI, NIH, 37 Convent Drive, Building 37, Room 1106A1,
> Bethesda, MD 20892-4254; 301-435-7587; <BV10w@nih.gov>

**James D. Yager, PhD**--- *Hormonal Carcinogenesis*

Professor, Division of Toxicology, Department of Environmental Health
Sciences; Senior Associate Dean of Academic Affairs, Johns Hopkins
Bloomberg School of Public Health, 615 N. Wolfe St., Room W1025,
Baltimore, MD 21205; 410-955-3348; jyager@jhsph.edu