The NCATS will total \$42,250.

Dates February 28, 2007 -- August 31, 2007

Firm will issue 12 checks on the following dates in the amount of
\$3520.83 each

March 15, 2007

March 30, 2007

April 15, 2007

April 30, 2007

May 15, 2007

May 30, 2007

June 15, 2007

June 30, 2007

July 15, 2007

July 30, 2007

August 15, 2007

August 29, 2007

Checks will be sent to Dr. Dr. Suk Keun Lee from Seoul, Korea payment to
Dr. Lee as Per Diem and Travel expenses during his stay at NIDCR,
CRC/HCGS.

The checks should be sent to the NIDCR for presentation to Dr. Lee on or
about the 15^th^ and 30^th^ of each month March, 2007 through August
2007.

Please send checks attention Elizabeth Powell to the following address:

Mrs. Tina Walton

30 Center Drive Room 1N103A

Building 10

Bethesda, MD 20892-1197

Telephone: 301-594-4215

Fax: 301-496-1005

Statement of Work for Suk Keun Lee

1.  [Objectives]{.underline}

> The contractor will work with Dr. Thomas Hart and other members of the
> Human and Craniofacial Genetics Section. The contractor will perform
> genetic, immunohistochemical and proteomic analysis of tissues from
> developing teeth and skin in the oral cavity in human and animal
> tissue samples. Dr. Lee's work will focus on identification of novel
> genes and proteins that determine normal development of these tissues.
> He will obtain appropriate tissue specimens from tissue repositories
> in Korea, and will isolate DNA, RNA and proteins from these tissues
> which he will evaluate in *in vitro* tissue culture assays in the
> Human and Craniofacial Genetics Section laboratory. These studies are
> aimed at characterization of key genes and proteins that may
> ultimately be used to develop novel treatments for oral, dental and
> craniofacial diseases.

2.  [Approach]{.underline}

> The contractor will be involved in ascertaining tissues of developing
> teeth and oral structures from existing tissue repositories. He will
> perform laser capture microdisection to isolate specific cell and
> tissue types that will be used to characterize gene and protein
> expression. The Contractor will be involved with tissue procurement
> will be responsible for preparation of samples and shipment to the
> Human and Craniofacial Genetics laboratory for analysis. The
> contractor will work with personnel from the Human and Craniofacial
> Genetics section in preparation of reports including scientific
> manuscript describing findings of molecular genetic studies.

3.  [Methods]{.underline}

> The services will be performed as follows:

a)  The contractor will participate in ongoing research related to
    characterization of genes and proteins in developing oral and dental
    structures, leading to the identification of specific genes and
    isoforms of genes expressed in developing craniofacial tissues.
    Specifically the contractor will ascertain tissue specimens and will
    be responsible for preparation of specimens for subsequent genomic
    and proteomic work.

b)  The contractor must have expertise in oral histology and oral
    pathology.

c)  The contractor will have expertise in molecular biology involving
    immunohistochemistry, genetic and proteomic analyses.

d)  The contractor will have expertise in expertise to perform standard
    biopsies of gingival tissues.

e)  The contractor will have expertise to guide in the performance of
    laser capture dissection of specimens.

f)  The contractor will maintain clear and accurate records relating to
    clinical information as well as tracking samples.

g)  The contractor should have excellent oral communication skills and
    be able to participate in writing scientific reports as well as
    clinical records.

[Personnel, evaluation and schedule]{.underline}

> [A. Personnel]{.underline}
>
> The contractor must have a working knowledge of general dentistry and
> expertise in development of the tissues and structures of the oral
> cavity. The contractor will have expertise in molecular biological
> approaches to characterize genes and proteins.The contractor will be
> skilled in sample preparation for DNA, RNA and protein isolation and
> for transport of tissue samples. Personnel provided under the contract
> will comply with the rules and policies of the NIDCR and its staff.
>
> [B. Evaluation]{.underline}
>
> The contractor is expected to work in an independent self-motivated
> fashion. The contractor is expected to work closely with the Section
> Chief and other members of the laboratory and will be evaluated at
> least once a week by discussing a weekly progress report with the
> section chief. If the contractor is considered to be substandard in
> the judgment of the section chief, the contractor will initially
> receive notice of the problem from the section chief and will be
> required to take corrective measures and to demonstrate improved
> performance.
>
> [C. Schedule]{.underline}
>
> The contractor will perform duties related to the study for a minimum
> of 40 hours a week.
>
> [D. Reporting Requirements]{.underline}
>
> The contractor shall provide professional services for the Human and
> Craniofacial Genetics Section, NIDCR during the period of February 28,
> 2007 to August 31, 2007. The contractor will be paid a total of
> \$42,000 for this 6 month period.
>
> **Justification**
>
> Attached is a request for \$42,000 to provide per Diem and travel for
> the services of Dr. **Suk Keun Lee**. Under this contract, Dr.Lee will
> provide clinical research services to the Human and Craniofacial
> Genetics Section, NIDCR. Her contract will run from Februrary 28, 2007
> to August 31, 2007. The work requires specialized clinical skills and
> basic research skills for sample preparation. Dr. Lee is a dentist
> with specialized training in the field of Oral Pathology. He is also
> experienced in understanding of human genetics related to development
> of oral and dental tissues. He is also an accomplished scientist with
> expertise in molecular biology.He has more than 50 scientifi articles
> in respected, peer reviewed journals. The procedures described need
> technical skill and expertise in the area of normal and abnormal oral
> tissue development..
>
> Additionally, Dr. Lee has the expertise and self motivation to
> successfully perform the project. He is familiar with all goals of the
> proposal, and understands when to support different aspects of the
> project to ensure successful completion. His specific expertise in the
> area of research of normal and abnormal oral tissues makes him an
> ideal candidate for this work.