**CURRICULUM VITAE**

**[Personal Information:]{.underline}**

Name: William G. Stetler-Stevenson, M.D., Ph.D.

Address:

Office/Mailing Address:

> Cell and Cancer Biology Branch, CCR, NCI

Vascular Biology Faculty, CCR, NCI

Advanced Technology Center

8717 Grovemont Circle, Room 115D

Bethesda, MD 20892-4605

Phone: (301) 402-1521

FAX: (301) 402-2628

Shipping Address:

> Cell and Cancer Biology Branch, CCR, NCI

Advanced Technology Center

8717 Grovemont Circle, Room 115D

Gaithersburg, MD 20877

Email: sstevenw@mail.nih.gov

Home: 9608 Byeforde Rd.

Kensington, MD 20895

Phone: (301) 929-0865

Date and Place of Birth: November 27, 1953; Trenton, New Jersey, USA

Citizenship: United States

**[Medical Licensure:]{.underline}**

> Physician and Surgeon, State of Maryland, Department of Health and
> Mental Hygiene, License, Registration, or Certification Renewal,
> Maryland State Board of Physician Quality Assurance, License Registry
> Certificate Number D35477; Drug Enforcement Administration Registered
> Practitioner

**[Medical Board Certification:]{.underline}**

> Diplomate, American Board of Pathology, Anatomic Pathology, August 28,
> 1990

**[Education]{.underline}:**

> 1975 -B.S.-Albright College, Reading, PA
>
> 1983 -Ph.D.-Northwestern University, Evanston, IL
>
> 1984 -M.D.-Northwestern University, Feinberg School of Medicine,
> Chicago, IL

**[Professional Experience:]{.underline}**

**Primary Appointments:**

> 1984-1987 Northwestern Memorial Hospital/McGaw Medical Center (House
> staff, Pathology Resident), Chicago, IL
>
> 1987-1991Senior Staff Fellow, Laboratory of Pathology, National Cancer
> Institute, National Institutes of Health, Bethesda, MD
>
> 1991-2003 Medical Officer (Research), Laboratory of Pathology,
> National Cancer Institute, National Institutes of Health, Bethesda, MD
>
> 1993-2003 Chief, Extracellular Matrix Pathology Section, Laboratory of
> Pathology, National Cancer Institute, National Institutes of Health,
> Bethesda, MD
>
> 2001-2004 Chair, Steering Committee, Vascular Biology Faculty, Center
> for Cancer Research, National Cancer Institute, National Institutes of
> Health, Bethesda, MD
>
> 2003-present Medical Officer (Research), Senior Investigator, Cell and
> Cancer Biology Branch, Center for Cancer Research, National Cancer
> Institute, National Institutes of Health, Bethesda, MD
>
> **Secondary Appointments:**
>
> 1993-present Adjunct Professor, Department of Cell Biology, Georgetown
> University Medical School
>
> 1994-present National Research Council, Research Advisor, Research
> Associateship Program

**[Honors and Scientific Recognition:]{.underline}**

> 1975 - Bachelor of Science Degree, cum laude, Albright College

1978 - Kemper Foundation Medical Scholar

1979 - Kemper Foundation Medical Scholar

> 1991 - Award of Merit, National Institutes of Health
>
> 1995- Northwestern University Pathology Association-
>
> Award for Outstanding Basic Research
>
> 1996- American Society for Investigative Pathology-
>
> Warner Lambert/Parke Davis Award
>
> 1998- Metastasis Research Society, President
>
> 2000- American Association of University Pathologists (Pluto Club)
>
> 2002- Watson Smith Lecturer, Royal College of Physicians (London)
>
> 2005- NCI Technology Transfer Award-Development and Commercial
> Licensing of the Directed In Vivo Angiogenesis Assay (DIVA assay)

**[Professional Society Memberships:]{.underline}**

American Society for Biochemistry and Molecular Biology

American Society for Investigative Pathology

American Association for Cancer Research

**[Public Service:]{.underline}**

**Editorial Boards:**

FASEB Journal, Editorial Board, 2002-present

> American Journal of Pathology, Associate Editor, 1997-2003

Editorial Board 1995-1997, 2003-present

Cancer Research, Associate Editor, 1999-present

Clinical Cancer Research, Editorial Board, 2002-present

Microvascular Research, Editorial Board 2001-present

Connective Tissue Research, Associate Editor, 1999-present

Gene Expression, Editorial Board, 2001-present

Cancer Gene Therapy, Editorial Board, 2001-present

Invasion and Metastasis, Associate Editor 1995-present

Diagnostic Molecular Pathology, Editorial Board, 1993-2000

**Journals ad hoc reviewer:**

The Journal of Biological Chemistry

The Journal of Cell Biology

Science

Nature

Nature Medicine

Journal of Clinical Investigation

Cell

**Study Sections:**

> National Cancer Institute of Canada, Site Visit Team Reviewer \[Dr. G.
> McFadden, Chair, 1991\]

Veterans Administration, Research Grants Administration, ad hoc Reviewer
\[1991\]

> NIH, Visual Sciences C Study Section, Reader \[Carole L. Jelsema,
> Ph.D.,
>
> Scientific Review Administrator, 1993\]
>
> NIH, Pathobiochemistry B Study Section (AHR-F1), Reviewer \[Philip
>
> Furmanski, Ph.D., Chairperson, Alec Liacouris, Ph.D., Scientific
> Review Administrator, 1994\]
>
> NIH, Pathology Group A Study Section, Reviewer \[Tucker Collins, M.D.,
> Ph.D., Chairperson, Larry Pinkus, Ph.D., Scientific Review
> Administrator, February, 1997\]
>
> NIH, Pathobiochemistry B Study Section, Reviewer \[Helene Sage, Ph.D.,
> Chairperson; Zakir Bengali, Ph.D., Scientific Review Administrator,
> February 1998\]
>
> NIH, Pathology Group A Study Section, Reviewer, \[Tucker Collins,
> M.D., Ph.D., Chairperson, Larry Pinkus, Ph.D., Scientific Review
> Administrator, February, 1999\]

# **Postgraduate Course Work:**

Senior Investigator Courses NIH Intramural Program

Introduction to leadership in scientific session

> Leadership Styles and Preferences (MBTI) completed Jan. 2005

Leadership Styles and Preferences (Skillscope) completed Jan. 2005

Teams: Working Through Motivating and Developing Others

Giving Developmental Feedback completed Feb. 2005

Managing Up completed Feb. 2005

Dealing with conflict completed March 2005

Negotiating/Hiring Skills completed March 2005

**[Administrative Experience:]{.underline}**

**Departmental:**

Resident Selection Committee, Laboratory of Pathology, DCBDC, NCI

Assistant Director, Anatomic Pathology Residency Training Program,

Laboratory of Pathology, NCI, 1995-2001

**Institutional:**

Extracellular Matrix Inter-institute Interest Group, Chairperson, 1996-9

Decision Network Committee, Division of Cancer Treatment, NCI, 1993-1996

Vascular Biology Faculty, CCR, NCI-Steering Committee, Chairperson,
2001-4

NCI-Japanese Cancer Institute Joint Symposium, U.S. Organizer, 2000

NIH Research Festival Plenary Session: Angiogenesis in Health and
Disease, Organizer and Chair, 2000

> NIH Promotion & Tenure Review Board, Ad hoc reviewer, 2001 & 2003

National Institute of Dental & Craniofacial Research- Search Committee
Chairperson, 2004

**National:**

American Society for Investigational Pathology Search Committee for
American Journal of Pathology Editor-In-Chief, 2002

American Society for Investigational Pathology Nominating Committee,
2001-2003

American Society for Investigational Pathology Five year Strategic
Planning Committee, 2003

NIH Trans-Institute Angiogenesis Research Program Workshop, Discussion
Leader, 2004

**International:**

President Elect, Metastasis Research Society, 1996

President, Metastasis Research Society, 1998

Chair of the Organizing Committee and Principal Organizer, International
Congress of the Metastasis Research Society, San Diego Hilton Hotel and
Beach Resort, 1998

**[Institutional/University Service:]{.underline}**

**Teaching Activities**:

> Pathology Resident Training, 1989-present, supervision of residents in
> Anatomic Pathology Training program at NCI.

**Research Advisor for Pathology Residents:**

David E. Kleiner, Jr., M.D., Ph.D. 1990-1992

Michael Emmert-Buck, MD., Ph.D. 1992-1995

Gary Oliver, M.D. 1994-1996

**Ph.D. Graduate Student Advisory Committees:**

> Quing-Xiang Sang, Georgetown University Medical School, Department of
> Cell Biology, 1988-1990.

Steve Seslar, Georgetown University Medical School, Department of

Cell Biology, 1991-1993.

Wayne Monsky, Georgetown University Medical School, Department of

Cell Biology, 1991-1993.

**Graduate Student Ph.D. Examining Committees:**

> Quing-Xiang Sang, Georgetown University Medical School, Department of
> Cell Biology, January 1990.

Steve Seslar, Georgetown University Medical School, Department of

Cell Biology, June 1993.

Wayne Monsky, Georgetown University Medical School, Department of

Cell Biology, June 1993.

**National Research Council Associateship Research Advisor:**

> Advisee: Bente Birkedal-Hansen, D.D.S.- Cellular Localization of
> Stromelysin-1/Stromelysin-2 and TIMP-1/TIMP-2 In Oral Premalignant
> Lesions.
>
> National Institutes of Health/National Council of Science and
> Technology of Mexico (CONACYT), Advisee: Georgina González-Avila,
> M.D., Ph.D.

**[Scholarship and Research:]{.underline}**

Research Interests:

> Molecular and genetic approaches to the study of the tissue
> microenvironment associated with tumor progression and angiogenesis,
> modeling and regulation of angiogenesis in human pathology, and
> protease inhibitor biology.

Patents:

> U. S. Patent No. 5, 270, 447 \"Metalloproteinase Peptides: Role in
> Diagnosis and Therapy\", Inventors: L. A. Liotta, W. G.
> Stetler-Stevenson and H. Krutzsch; Issued December 14, 1993.
>
> U. S. Patent No. 5, 280, 106 \"Matrix Metalloproteinase Peptides: Role
> in Diagnosis and Therapy\", Inventors: L.A. Liotta, W.G.
> Stetler-Stevenson and H.C. Krutzsch; Issued January 10, 1994.
>
> U. S. Patent No. 5, 372, 809 Inventors: W. G. Stetler-Stevenson and L.
> A. Liotta; Issued December 13, 1994
>
> U.S. Patent No. 5,595,885 Inventors: W. G. Stetler-Stevenson, L.A.
> Liotta and H.C. Krutzsch; Issued January 21, 1997
>
> U.S. Patent Application: "TIMP-2 Angio-Inhibitory Peptides";
> Inventors: W. G. Stetler-Stevenson and D.-W. Seo, Filed September
> 2005.

**[Publications:]{.underline}**

Overview of Publications during the last 10 years (**Scientific
Impact**):

**Scopus** Brought to you by National Institutes of Health Library

Citation Overview: Citations received since 1996

Note: Self Citations of above author are **excluded**.

Author: **Stetler-Stevenson, William G.**

Documents: 1996-2007 = 222 Cited Documents

Citations:

Year prior to 2005 2005 2006 2007 Total Citations

14996 1303 1243 259 17865

Summary: 17865 citations/222 publications Average: 80.5
citations/publication

**Original Publications:**

1\. **Stetler-Stevenson, W. G.** and Veis, A.: Bovine dentin
phosphophoryn: Composition and molecular weight. *Biochemistry*
22:4326-4335, 1983.

2\. **Stetler-Stevenson, W. G.** and Veis, A.: Type I collagen shows a
specific binding affinity for bovine dentin phosphophoryn. *Calcif.
Tiss. Int**.*** **38**:l35-l4l, 1986.

3\. **Stetler-Stevenson, W. G.** and Veis, A.: Bovine dentin
phosphophoryn: Calcium ion binding properties of a high molecular weight
preparation. *Calcif. Tiss. Int.* **40**:97-l02, 1987.

4\. Hoyhtya, M., Turpeenniemi-Hujanen, T., **Stetler-Stevenson, W.**,
Krutzsch, H., Tryggvason, K., and Liotta, L. A.: Monoclonal antibodies
to type IV collagenase recognize a protein with limited sequence
homology to interstitial collagenase and stromelysin. *FEBS Lett**.***
**233**:l09-ll3, 1988.

5\. **Stetler-Stevenson, W. G.**, Krutzsch, H. C., Wacher, M. P.,
Margulies, I. M. K., and Liotta, L. A.: The activation of human type IV
collagenase proenzyme. Sequence identification of the major conversion
product following organomercurial activation. *J. Biol. Chem.*
**264**:l353-l356, 1989.

6\. Liotta, L. A. and **Stetler-Stevenson, W. G.**: Metalloproteinases
and malignant conversion: Does correlation imply causality? *J. Natl.
Cancer Inst.* **8l**:556-557, 1989.

7\. **Stetler-Stevenson, W. G.**, Krutzsch, H. C., and Liotta, L. A.:
Tissue inhibitor of metalloproteinase (TIMP-2): A new member of the
metalloproteinase inhibitor family. *J. Biol. Chem.*
**264**:l7374-l7378, 1989.

8\. **Stetler-Stevenson, W. G.**, Lurain, J. R., and Murad, T.:
Placental site trophoblastic tumor associated with immature ovarian
teratoma. *Int. J. Gynecol. Obstet.* **32**:275-279, 1990.

9\. Monteagudo, C., Merino, M. J., San-Juan, J., Liotta, L. A., and
**Stetler-Stevenson, W. G.**: Immunohistochemical distribution of type
IV collagenase in normal, benign and malignant breast tissue. *Am. J.
Pathol.* **l36**:585-592, 1990.

l0. Wacher, M. P., Krutzsch, H. C., Liotta, L. A., and
**Stetler-Stevenson, W. G.**: Development of a novel substrate capture
immunoassay for the detection of a neutral metalloproteinase capable of
degrading basement membrane (type IV) collagen. *J. Immunol. Meth.*
**l26**:239-245, 1990.

l1. Zucker, S., Moll, U. M., Lysik, R. M., DiMassimo, E. I.,
**Stetler-Stevenson, W. G.**, Liotta, L. A., and Schwedes, J. W.:
Extraction of type IV collagenase/gelatinase from plasma membranes of
human cancer cells. *Int. J. Cancer* **45**:ll37-ll42, 1990.

l2. Hendrix, M. J. C., Wood, W. R., Seftor, E. A., Lotan, D., Nakajima,
M., Misiorowski, R. L., Seftor, R. E. B., **Stetler-Stevenson, W. G.**,
Bevacqua, S. J., Liotta, L. A., Sobel, M. E., and Lotan, R.: Retinoic
acid inhibition of human melanoma cell invasion through a reconstituted
basement membrane and its relation to decreases in the expression of
proteolytic enzymes and motility factor receptor. *Cancer Res.*
**50**:4l2l-4l30, 1990.

l3. Sang, Q.-X., **Stetler-Stevenson, W. G.**, Liotta, L. A., and Byers,
S. W.: Identification of type IV collagenase in rat testicular cell
culture: Influence of peritubular-Sertoli cell interactions. *Biol.
Reprod.* **43**:956-964, 1990.

l4. Liotta, L. A. and **Stetler-Stevenson, W. G.**: Metalloproteinases
and cancer invasion. *Semin. Cancer Biol*. **l**:99-l06, 1990.

15\. Brown, P. D., Levy, A. T., Margulies, I. M. K., Liotta, L. A., and
**Stetler-Stevenson, W. G.**: Independent expression and cellular
processing of Mr 72,000 type IV collagenase and interstitial collagenase
in human tumorigenic cell lines. *Cancer Res.* **50**:6l84-619l, 1990.

16\. **Stetler-Stevenson, W. G.**, Brown, P. D., Onisto, M., Levy, A.
T., and Liotta, L. A.: Tissue inhibitor of metalloproteinases-2 (TIMP-2)
mRNA expression in tumor cell lines and human tumor tissues. *J. Biol.
Chem.* **265**:l3933-l3938, 1990.

17\. Templeton, N. S., Brown, P. D., Levy, A. T., Margulies, I. M. K.,
Liotta, L. A., and **Stetler-Stevenson, W. G.**: Cloning and
characterization of human tumor cell interstitial collagenase. *Cancer
Res.* **50**:543l-5437, 1990.

18\. **Stetler-Stevenson, W. G.**: Type IV collagenases in tumor
invasion and metastasis. *Cancer Metast. Rev.* **9**:289-303, 1990.

19\. Weinberg, W. C., Brown, P. D., **Stetler-Stevenson, W. G.**, and
Yuspa, S. H.: Growth factors specifically alter hair follicle cell
proliferation and collagenolytic activity alone or in combination.
*Differentiation* **45**:168-178, 1990.

20\. Levy, A. T., Cioce, V., Sobel, M. E., Garbisa, S., Grigioni, W. F.,
Liotta, L. A., and **Stetler-Stevenson, W. G.**: Increased expression of
the Mr 72,000 type IV collagenase in human colonic adenocarcinoma.
*Cancer Res.* **5l**:439-444, 199l.

21\. Liotta, L. A., Steeg, P. S., and **Stetler-Stevenson, W. G.**:
Cancer metastasis and angiogenesis: An imbalance of positive and
negative regulation. *Cell* **64**:327-336, 199l.

22\. D\'Errico, A., Garbisa, S., Liotta, L. A., Castronovo, V.,
**Stetler-Stevenson, W. G.**, and Grigioni, W. F.: Augmentation of type
IV collagenase, laminin receptor, and Ki67 proliferation antigen
associated with human colon, gastric, and breast carcinoma progression.
*Mod. Pathol.* **4**:239-246, 1991.

23\. Grigioni, W. F., Garbisa, S., D\'Errico, A., Baccarini, P.,
**Stetler-Stevenson, W. G.**, Liotta, L. A., and Mancini, A. M.:
Evaluation of hepatocellular carcinoma aggressiveness by a panel of
extracellular matrix antigens. *Am. J. Pathol.* **138**:647-654, 199l.

24\. Sabsay, B., **Stetler-Stevenson, W. G.**, Lechner, J. H., and Veis,
A.: Domain structure and sequence distribution in dentin phosphophoryn.

*Biochem. J.* **276**:699-707, 1991.

25\. **Stetler-Stevenson, W. G.**, Talano, J., Gallagher, M. E.,
Krutzsch, H. C., and Liotta, L. A.: Inhibition of human type IV
collagenase by a highly conserved peptide sequence derived from its
prosegment. *Am. J. Med. Sci.* **302**:163-170, 1991.

26\. Albini, A., Melchiori, A., Santi, L., Liotta, L. A., Brown, P. D.,
and **Stetler-Stevenson, W. G.**: Tumor cell invasion inhibited by
TIMP-2. *J. Natl. Cancer Inst.* **83**:775-779, 1991.

27\. Seftor, R. E. B., Seftor, E. A., Grimes, W. J., Liotta, L. A.,
**Stetler-Stevenson, W. G.**, Welch, D. R., and Hendrix, M. J. C.: Human
melanoma cell invasion in vitro is inhibited by swainsonine and
deoxymannojirimycin with a concomitant decrease in collagenase IV
expression. *Melanoma Res.* **1**:43-54, 1991.

28\. Templeton, N. and **Stetler-Stevenson, W. G.**: Identification of a
basal promoter for the human Mr 72,000 type IV collagenase gene and
enhanced expression in a highly metastatic cell line. *Cancer Res.*
**51**:6190-6193, 1991.

29\. Sang, Q.-X., Thompson, E. W., Grant, D., **Stetler-Stevenson, W.
G.**, and Byers, S. W.: Soluble laminin and arginine-glycine-aspartic
acid containing peptides differentially regulate type IV collagenase
messenger RNA, activation and localization in testicular cell culture.
*Biol. Reproduct.* **45**:387-394, 1991.

30\. Liotta, L. A. and **Stetler-Stevenson, W. G.**: Tumor invasion and
metastasis: an imbalance of positive and negative regulation. *Cancer
Res.* **51**:5054s-5059s, 1991.

31\. Liotta, L. A., **Stetler-Stevenson, W. G.**, and Steeg, P. S.:
Cancer invasion and metastasis: positive and negative regulatory
elements. *Cancer Invest.* **9**:543-551, 1991.

32\. Ailenberg, M., **Stetler-Stevenson, W. G.**, and Fritz, I. B.:
Secretion of latent type IV procollagenase and active type IV
collagenase by testicular cells in culture. *Biochem. J.* **279**:75-80,
1991.

33\. Templeton, N. S., Rodgers, L. A., Levy, A. T., Ting, K.-L.,
Krutzsch, H. C., Liotta, L. A., and **Stetler-Stevenson, W. G.**:
Cloning and characterization of a novel human cDNA that has DNA
similarity to the conserved region of the collagenase gene family.
*Genomics* **12**:175-176, 1992.

34\. Corcoran, M. L., **Stetler-Stevenson, W. G.**, Brown, P. D., and
Wahl, L. M.: Interleukin 4 inhibition of prostaglandin E2 synthesis
blocks interstitial collagenase and 92-type IV collagenase/gelatinase
production by human monocytes. *J. Biol. Chem.* **267**:515-519, 1992.

35\. **Stetler-Stevenson, W. G.**, Bersch, N., and Golde, D. W.: Tissue
inhibitor of metalloproteinase-2 (TIMP-2) has erythroid-potentiating
activity. *FEBS Lett.* **296**:231-234, 1992.

36\. Hendrix, M. J. C., Seftor, E. A., Chu, Y.-W., Seftor, R. E. B.,
Nagle, R. B., McDaniel, K. M., Leong, S. P. L., Yohem, K. H., Leibovitz,
A. M., Meyskens, F. L., Jr., Conaway, D. H., Welch, D. R., Liotta, L.
A., and **Stetler-Stevenson, W. G.**: Coexpression of vimentin and
keratins by human melanoma tumor cells: Correlation with invasive and
metastatic potential. *J. Natl. Cancer Inst.* **84**:165-174, 1992.

37\. **Stetler-Stevenson, W. G.**, Krutzsch, H. C., and Liotta, L. A.:
TIMP-2: Identification and characterization of a new member of the
metalloproteinase inhibitor family. *Matrix* **(Supplement 1)**:
299-306, 1992.

38\. Seftor, R. E. B., Seftor, E. A., Gehlsen, K. R.,
**Stetler-Stevenson, W. G.**, Brown, P. D., Ruoslahti, E., and Hendrix,
M. J. C.: Role of the avﬂ3 integrin in human melanoma cell invasion.
*Proc. Natl. Acad. Sci. USA* **89**:1557-1561, 1992.

39\. Kleiner, D. E., Jr., Unsworth, E. J., Krutzsch, H. C., and
**Stetler-Stevenson, W. G.**: Higher-order complex formation between the
72-kilodalton type IV collagenase and tissue inhibitor of
metalloproteinases-2. *Biochemistry* **31**:1665-1672, 1992.

40\. Hendrix, M. J. C., Seftor, E. A., Grogan, T. M., Seftor, R. E. B.,
Hersh, E. M., Boyse, E. A., Liotta, L. A., **Stetler-Stevenson, W. G.**,
and Ray, C. G.: Expression of type IV collagenase correlates with the
invasion of human lymphoblastoid cell lines and pathogenesis in SCID
mice. *Mol. Cell. Probes* **6**:59-65, 1992.

41\. Rosenberg, G. A., Kornfeld, M., Estrada, E., Kelley, R. O., Liotta,
L. A., and **Stetler-Stevenson, W. G.**: TIMP-2 blocks proteolytic
opening of blood-brain barrier by type IV collagenase. *Brain Res.*
**576**:203-207, 1992.

42\. Zucker, S., Lysik, R. M., Gurfinkel, M., Zarrabi, M. H.,
**Stetler-Stevenson, W. G.**, Liotta, L. A., Birkedal-Hansen, H., and
Mann, W.: Immunoassay of type IV collagenase/gelatinase (MMP-2) in human
plasma. *J. Immunol. Meth.* **148**:189-198, 1992.

43\. Campo, E., Merino, M. J., Liotta, L. A., Neumann, R., and
**Stetler-Stevenson, W. G.**: Distribution of the 72 kDa type IV
collagenase in non-neoplastic and neoplastic thyroid tissue. *Hum.
Pathol.* **23**:1395-1401, 1992.

44\. Campo, E., Merino, M. J., Tavassoli, F. A., Charonis, A. S.,
**Stetler-Stevenson, W. G.**, and Liotta, L. A.: Evaluation of basement
membrane components and the 72 kDa type IV collagenase in serous tumors
of the ovary. *Am. J. Surg. Pathol.* **16**:500-507, 1992.

45\. Fernandez, P. L., Merino, M. J., Nogales, F. F., Charonis, A. S.,
**Stetler-Stevenson, W. G.**, and Liotta, L. A.: Immunohistochemical
profile of basement membrane proteins and 72 kilodalton type IV
collagenase in the implantation placental site: An integrated view.
*Lab. Invest.* **66**:572-579, 1992.

46\. Melchiori, A., Albini, A., Ray, J. M., and **Stetler-Stevenson, W.
G.**: Inhibition of tumor cell invasion by a highly conserved peptide
sequence from the matrix metalloproteinase enzyme prosegment. *Cancer
Res.* **52**:2353-2356, 1992.

47\. Poulsom, R., Pignatelli, M., **Stetler-Stevenson, W. G.**, Liotta,
L. A., Wright, P. A., Jeffery, R. E., Longcroft, J. A., Rogers, L., and
Stamp, G. W. H.: Stromal expression of 72 kda type IV collagenase and
(MMP-2) and TIMP-2 mRNAs in colorectal neoplasia. *Am. J. Pathol.*
**141**:389-396, 1992.

48\. Weinberg, W. C., Brown, P. D., **Stetler-Stevenson, W. G.**, and
Yuspa, S. H.: Modulation of hair follicle cell proliferation and
collagenolytic activity by specific growth factors. *Ann. N.Y. Acad.
Sci.* **642**:281-290, 1992.

49\. Garbisa, A., Scagliotti, G., Masiero, L., Di Francesco, C.,
Caenazzo, C., Onisto, M., Micela, M., **Stetler-Stevenson, W. G.**, and
Liotta, L. A.: Correlation of serum metalloproteinase levels with lung
cancer metastasis and response to therapy. *Cancer Res.*
**52**:4548-4549, 1992.

50\. Margulies, I. M. K., Hoyhtya, M., Evans, C., Stracke, M. L.,
Liotta, L. A., and **Stetler-Stevenson, W. G.**: Urinary type IV
collagenase: Elevated levels are associated with bladder transitional
cell carcinoma. *Cancer Epidemiol., Biomark. Prevent.* **1**:467-474,
1992.

51\. Moutsiakis, D., Mancuso, P., Krutzsch, H., **Stetler-Stevenson,
W.**, and Zucker, S.: Characterization of metalloproteinases and tissue
inhibitors of metalloproteinases in human plasma. *Connect. Tissue Res.*
**28**: 213-230, 1992.

52\. Sreenath, T., Matrisian, L. M., **Stetler-Stevenson, W. G.**,
Galtoni-Celli, S., and Pozzatti, R. O.: Expression of matrix
metalloproteinase genes in transformed rat cell lines of high and low
metastatic potential. *Cancer Res.* **52**:4942-4947, 1992.

53\. van den Brule, F. A., Engel, J., **Stetler-Stevenson, W. G.**, Liu,
F.-T., Sobel, M. E., and Castronovo, V.: Genes involved in tumor
invasion and metastasis are differentially modulated by estradiol and
progestin in human breast cancer cells. *Int. J. Cancer* **52**:653-657,
1992.

54\. Fridman, R., Fuerst, T. R., Bird, R. E., Hoyhtya, M., Oelkuct, M.,
Kraus, S., Komarek, D., Liotta, L. A., Berman, M. L., and
**Stetler-Stevenson, W. G.**: Domain structure of human 72 kDa
gelatinase/type IV collagenase: Characterization of proteolytic activity
and identification of the tissue inhibitor of metalloproteinase-2
(TIMP-2) binding regions. *J. Biol. Chem.* **267**:15398-15405, 1992.

55\. Emonard, H. P., Remacle, A. G., Noël, A. C., Grimaud, J.-A.,
**Stetler-Stevenson, W. G.**, and Foidart, J.-M.: Tumor cell
surface-associated binding site for the Mr 72,000 type IV collagenase.
*Cancer Res.* **52**:5845-5848, 1992.

56\. Ohori, N. P., Yousem, S. A., Griffin, J., Stanis, K.,
**Stetler-Stevenson, W. G.**, Colby, T. V., and Sonmez-Alpan, E.:
Comparison of extracellular matrix antigens in subtypes of
bronchioloalveolar carcinoma and conventional pulmonary adenocarcinoma.
An immunohistochemical study. *Am. J. Surg. Pathol.* **16**:675-686,
1992.

57\. Mullen, C. A., Coale, M., Levy, A., **Stetler-Stevenson, W. G.**,
Liotta, L. A., Brandt, S., and Blaese, R. M.: Fibrosarcoma cells
transduced with the IL-6 gene exhibit reduced tumorigenicity, increased
immunugenicity and decreased metastatic potential. *Cancer Res.*
**52**:6020-6024, 1992.

58\. Zucker, S., Lysik, R. M., Zarraki, M. H., **Stetler-Stevenson, W.
G.**, Liotta, L. A., Birkedal-Hansen, H., Mann, W., and Furie, M.: Type
IV collagenase/gelatinase (MMP-2) is not increased in plasma of patients
with cancer. *Biomark. Cancer Prevent.* **1**:475-479, 1992.

59\. **Stetler-Stevenson, W. G.**, Liotta, L. A., and Seldin, M. F.:
Linkage analysis demonstrates that the Timp-2 locus is on mouse
chromosome 11. *Genomics* **14**:828-829, 1992.

60\. Brown, P. D., Kleiner, D. E., Unsworth, E. J., and
**Stetler-Stevenson, W. G.**: Cellular activation of 72-kDa type IV
procollagenase/TIMP-2 complex. *Kidney Int.* **43**:163-170, 1993.

61\. Fridman, R., Bird, R. E., Hoyhtya, M., Oelkuck, M., Komarek, D.,
Liang, C.-M., Berman, M. L., Liotta, L. A., **Stetler-Stevenson, W.
G.**, and Fuerst, T. R.: Expression of human recombinant 72 kDa
gelatinase and TIMP-2: Characterization of complex and free enzyme.
*Biochem. J.* **289**:411-416, 1993.

62\. Aznavoorian, S., Murphy, A. N., **Stetler-Stevenson, W. G.**, and
Liotta, L. A.: Molecular aspects of tumor cell invasion and metastasis.
*Cancer* **71**:1368-1383, 1993.

63\. Kleiner, D. E., Jr., Tuuttila, A., Tryggvason, K., and
**Stetler-Stevenson, W. G.**: Stability analysis of latent and active
72-kDa type IV collagenase: The role of tissue inhibitor of
metalloproteinases-2 (TIMP-2). *Biochemistry* **32**:1583-1592, 1993.

64\. Carome, M. A., Striker, L. J., Peten, E. P., Moore, J., Yang,
C.-W., **Stetler-Stevenson, W. G.**, and Striker, G. E.: Human glomeruli
express tissue inhibitor of metalloproteinases-1 (TIMP-1) mRNA and
TIMP-2 protein and mRNA in vivo. *Am. J. Physiol.* **264**: F923-F929,
1993.

65\. Monsky, W. L., Kelly, T., Lin, C.-Y., Yeh, Y., **Stetler-Stevenson,
W. G.**, Mueller, S. C., and Chen, W.-T.: Binding and processing of 72
kDa matrix metalloproteinase at cell surface invadopodia. *Cancer Res.*
**53**:3159-3164, 1993.

66\. Rao, J. S., Steck, P. A., Mohanam, S., **Stetler-Stevenson, W.
G.**, Liotta, L. A., and Sawaya, R.: Elevated levels of 92-kDa type IV
collagenase in human brain tumors. *Cancer Res.* **53**: 2208-2211,
1993.

67\. Schnaper, H. W., Grant, D. S., **Stetler-Stevenson, W. G.**,
Fridman, R., D\'Orazi, G., Murphy, A. N., Bird, R. E., Hoythya, M.,
Fuerst, T., French, D. L., Quigley, J. P., and Kleinman, H. K.: Type IV
collagenase(s) and TIMPs modulate endothelial cell morphogenesis in
vitro. *J. Cell. Physiol.* **156**: 235-246, 1993.

68\. Onisto, M., Garbisa, S., Caenazzo, C., Freda, M. P., Di Francesco,
C., Nitti, D., Liotta, L. A., and **Stetler-Stevenson, W. G.**: RT-PCR
phenotyping of metalloproteinases and inhibitors involved in tumor
matrix invasion. *Diag. Molec. Pathol.* **2**: 74-80, 1993.

69\. **Stetler-Stevenson, W. G.**, Aznavoorian, S., and Liotta, L. A.:
Tumor cell interactions with the extracellular matrix during invasion
and metastasis. *Ann. Rev. Cell Biol.* **9**: 541-573, 1993.

70\. Kleiner, D. E., Jr. and **Stetler-Stevenson, W. G.**: Structural
biochemistry and activation of matrix metalloproteases. *Curr. Opin.
Cell Biol.* **5**: 891-897, 1993.

71\. Murphy, A. N., Unsworth, E. J., and **Stetler-Stevenson, W. G.**:
Tissue inhibitor of metalloproteinases-2 (TIMP-2) inhibits human
microvascular endothelial cell proliferation. *J. Cell. Physiol.*
**157**: 351-358, 1993.

72\. Seftor, R. E. B., Seftor, E. A., **Stetler-Stevenson, W. G.**, and
Hendrix, M. J. C.: The 72 kDa type IV collagenase is modulated via
differential expression of V3 and 51 integrins during human melanoma
cell invasion. *Cancer Res.* **53**: 3411-3415, 1993.

73\. Weeks, B. S., Klotman, M. E., Holloway, E., **Stetler-Stevenson, W.
G.**, Kleinman, H. K., and Klotman, P. E.: HIV-1 infection stimulates
T-cell invasiveness and synthesis of the 92 kDa type IV collagenase.
*AIDS Res. Hum. Retroviruses* **9**: 513-518, 1993.

74\. Mohtai, M., Smith, R. L., Schurman, D. J., Tsuji, Y., Torti, F. M.,
Hutchinson, N. I., **Stetler-Stevenson, W. G.**, and Goldberg, G. I.:
Expression of 92-kD type IV collagenase/gelatinase (gelatinase B) in
osteoarthritic cartilage and its induction in normal human articular
cartilage by interleukin 1. *J. Clin. Invest.* **92**: 179-185, 1993.

75\. **Stetler-Stevenson, W. G.**, Liotta, L. A., and Kleiner, D. E.,
Jr.: Extracellular matrix in tumor invasion and metastasis. *FASEB J.*
**7**: 1434-1441, 1993.

76\. Rao, J. S., Steck, P. A., Tofilon, P., Boyd, D., Ali-Osman, F.,
**Stetler-Stevenson, W. G.**, Liotta, L. A., and Sawaya, R.: Role of
plasminogen activator and of 92-kDa type IV collagenase in glioblastoma
invasion using an in vitro matrigel model. *J. Neurooncol.* **18**:
129-138, 1993.

77\. Leone, A., Correale, M., Dragone, C. D., Paradiso, A., De Lena, M.,
**Stetler-Stevenson, W. G.**, Liotta, L. A., Masiero, L., and Garbisa,
S.: Gelatinase A/MMP-2 serum levels and neoplastic progression in breast
cancer patients. *Int. J. Oncol.* **4**: 551-554, 1994.

78\. Hoyhtya, M., Fridman, R., Komarek, D., Porter-Jordan, K.,
**Stetler-Stevenson, W. G.**, Liotta, L. A., and Liang, C.-M.:
Immunohistochemical localization of matrix metalloproteinase 2 and its
specific inhibitor TIMP-2 in neoplastic tissues with monoclonal
antibodies. *Int. J. Cancer* **56**: 500-505, 1994.

79\. Kleiner, D. E. and **Stetler-Stevenson, W. G.**: Quantitative
zymography: detection of picogram quantities of gelatinases. *Anal.
Biochem.* **218**: 325-329, 1994.

80\. Sawaya, R., Tofilon, P. J., Mohanam, S., Ali-Osman, F., Liotta, L.
A., **Stetler-Stevenson, W. G.**, and Rao, J. S.: Induction of
tissue-type plasminogen activator and 72 kDa type IV collagenase by
ionizing radiation in rat astrocytes. *Int. J. Cancer* **56**: 214-218,
1994.

81\. Woodhouse, E., Hersperger, E., **Stetler-Stevenson, W. G.**,
Liotta, L. A., and Shearn, A.: Increased type IV collagenase in
lgl-induced invasive tumors of Drosophila. *Cell Growth Differ.* **5**:
151-159, 1994.

82\. Wucherpfennig, A. L., Li, Y.-P., **Stetler-Stevenson, W. G.**,
Rosenberg, A., and Stashenko, P.: Expression of 92 kDa-type IV
collagenase in human osteoclasts but not osteoblasts. *J. Bone Mineral
Res.* **9**: 549-556, 1994.

83\. Jares, P., Fernandez, P. L., Blay, M., Aiza, G.,
**Stetler-Stevenson, W. G.**, Cardesa, A., and Campo, E.: Taq 1
polymorphism of the human tissue inhibitor of metalloproteinases-2
(Timp-2) gene. *Hum. Molec. Genet.* **3**: 218, 1994.

84\. Ray, J. M. and **Stetler-Stevenson, W. G.**: TIMP-2 expression
modulates human melanoma cell adhesion and motility. *Ann. N.Y. Acad.
Sci.* **732**: 233-247, 1994.

85\. Grigioni, W. F., D\'Errico, A., Fiorentino, M., Baccarini, P.,
Onisto, M., Caenazzo, C., **Stetler-Stevenson, W. G.**, Garbisa, S., and
Mancini, A. M.: Gelatinase A (MMP-2) and its mRNA detected in both
neoplastic and stromal cells of tumors with different invasive and
metastatic properties. *Diag. Molec. Pathol.* **3**: 163-169, 1994.

86\. Zucker, S., Lysik, R. M., Zarrabi, H. M., Moll, U., Tickle, S. P.,
**Stetler-Stevenson, W. G.**, Baker, T. S., and Doherty, J. P.: Plasma
assay of matrix metalloproteinases (MMPs) and MMP-inhibitor complexes in
cancer: Potential use in predicting metastasis and monitoring treatment.
*Ann. N.Y. Acad. Sci.* **732**: 248-262, 1994.

87\. Grigioni, W. F., D\'Errico, A., Fortunato, C., Fiorentino, M.,
Mancini, A. M., **Stetler-Stevenson, W. G.**, Sobel, M. E., Liotta, L.
A., Onisto, M., and Garbisa, S.: Prognosis of gastric carcinoma revealed
by interactions between tumor cells and basement membrane. *Mod.
Pathol.* **7**: 220-225, 1994.

88\. Costello, P. C., Del Maestro, R. F., and **Stetler-Stevenson, W.
G.**: Gelatinase A expression in human malignant gliomas. *Ann. N.Y.
Acad. Sci.* **732**: 450-452, 1994.

89\. Rosenberg, G. A., Dencoff, J. E., McGuire, P. G., Liotta, L. A.,
and **Stetler-Stevenson, W. G.**: Injury induced 92-kilodalton
gelatinase and urokinase expression in rat brain. *Lab. Invest.* **71**:
417-422, 1994.

90\. Polette, M., Gilbert, N., Stas, I., Nawrocki, B., Noël, A.,
Remacle, A., **Stetler-Stevenson, W. G.**, Birembaut, P., and Foidart,
J. M.: Gelatinase A expression and localization in human breast cancers.
An in situ hybridization study and immunohistochemical detection using
confocal microscopy. *Virchows Arch.* **424**: 641-645, 1994.

91\. Corcoran, M. L., **Stetler-Stevenson, W. G.**, DeWitt, D. L., and
Wahl, L. M.: Effect of cholera toxin and pertussis toxin on
prostaglandin H synthetase-2, prostaglandin E-2, and matrix
metalloproteinase production by human monocytes. *Arch. Biochem.
Biophys.* **310**: 481-488, 1994.

92\. Mertz, P. M., DeWitt, D. L., **Stetler-Stevenson, W. G.**, and
Wahl, M. L.: Interleukin 10 suppression of monocyte prostaglandin H
synthetase-2. *J. Biol. Chem.* **269**: 21322-21329, 1994.

93\. Albini, A., Fontanini, G., Masiello, L., Tacchetti, C., Bigini, D.,
Luzzi, P., Noonan, D. M., and **Stetler-Stevenson, W. G.**: Angiogenic
potential in vivo by Kaposi\'s sarcoma cell-free supernatants and HIV-1
tat product: inhibition of KS-like lesions by tissue inhibitor of
metalloproteinase-2. *AIDS* **8**:1237-1244, 1994.

94\. Kohn, E. C., Jacobs, W., Kim, Y. S., Alessandro, R.,
**Stetler-Stevenson, W. G.**, and Liotta, L. A.: Calcium influx
modulates expression of matrix metalloproteinase-2 (72-kDa type IV
collagenase, gelatinase A). *J. Biol. Chem.* **269**: 21505-21511, 1994.

95\. Emmert-Buck, M. R., Roth, M. J., Zhuang, Z., Campo, E., Rozhin, J.,
Sloane, B., Liotta, L. A., and **Stetler-Stevenson, W. G.**: Increased
gelatinase A (MMP-2) and cathepsin B activity in invasive tumor regions
of human colon cancer samples. *Am. J. Pathol.* **145**: 1285-1290,
1994.

96\. Graham, C. H., Connelly, I., MacDougall, J. R., Kerbel, R. S.,
**Stetler-Stevenson, W. G.**, and Lala, P. K.: Resistance of malignant
trophoblast cells to both the anti-proliferative and anti-invasive
action of transforming growth factor-ß. *Exp. Cell Res.* **214**: 93-99,
1994.

97\. Ulisse, S., Farina, A. R., Piersanti, D., Tiberio, A., Cappabianca,
L., D\'Orazi, G., Jannini, E. A., Malykh, O., **Stetler-Stevenson, W.
G.**, D\'Armiento, M., Gulino, A., and MacKay, A. R.: Follicle
stimulating hormone increases the expression of tissue inhibitors of
metalloproteinases TIMP-1 and TIMP-2 and induces TIMP-1 AP-1 site
binding complex(es) in prepubertal rat Sertoli cells. *Endocrinology*
**135**: 2479-2487, 1994.

98\. Ochieng, J., Fridman, R., Nangia-Makker, P., Kleiner, D. E.,
Liotta, L. A., **Stetler-Stevenson, W. G.**, and Raz, A.: Galectin-3 is
a novel substrate for human matrix metalloproteinases-2 and -9.
*Biochemistry* **33**: 14109-14114, 1994.

99\. Liu, L., Shack, S., **Stetler-Stevenson, W. G.**, Hudgins, W. R.,
and Samid, D.: Differentiation of cultured human melanoma cells induced
by the aromatic fatty acid phenylacetate and phenylbutyrate. *J. Invest.
Dermatol.* **103**: 335-340, 1994.

100\. Benelli, R., Adatia, R., Ensoli, B., **Stetler-Stevenson, W. G.**,
Santi, L., and Albini, A.: Inhibition of AIDS-Kaposi\'s sarcoma cell
induced endothelial cell invasion by TIMP-2 and a synthetic peptide from
the metalloproteinase propeptide: Implications for an anti-angiogenic
therapy. *Oncol. Res.* **6**: 251-257, 1994.

101\. Ray, J. M. and **Stetler-Stevenson, W. G.**: The role of matrix
metalloproteinases and their inhibitors in tumor invasion, metastasis
and angiogenesis. *Eur. Respir. J.* **7**: 2062-2072, 1994.

102\. Carome, M. A., Striker, L. J., Peten, E. P., Elliot, S. J., Yang,
C.-W., **Stetler-Stevenson, W. G.**, Reponen, P., Tryggvason, K., and
Striker, G. E.: Assessment of 72-kilodalton gelatinase and TIMP-1 gene
expression in normal and sclerotic murine glomeruli. *J. Am. Soc.
Nephrol.* **5**: 1391-1399, 1994.

103\. Vadillo-Ortega, F., González-Avila, G., Furth, E. E., Lei, H.,
Muschel, R. J., **Stetler-Stevenson, W. G.**, and Strauss, J. F. III:
92-kD type IV collagenase (matrix metalloproteinase-9) activity in human
amniochorion increases with labor. *Am. J. Pathol.* **146**: 148-156,
1995.

104\. Ray, J. M. and **Stetler-Stevenson, W. G.**: Gelatinase A activity
directly modulates melanoma cell adhesion and spreading. *EMBO J.*
**14**: 908-917, 1995.

105\. Rutka, J. T., Matsuzawa, K., Hubbard, S. L., Fukuyama, K., Becker,
L. E., **Stetler-Stevenson, W. G.**, Edwards, D. R., and Dirks, P. B.:
Expression of TIMP-1, TIMP-2, 72- and 92-kDa type IV collagenase
transcripts in human astrocytoma cell lines: Correlation with
astrocytoma cell invasiveness. *Int. J. Oncol.* **6**: 877-884, 1995.

106\. Mohanam, S., Wang, S. W., Rayford, A., Yamamoto, M., Sawaya, R.,
Nakajima, M., Liotta, L. A., Nicolson, G. L., **Stetler-Stevenson, W.
G.**, and Rao, J. S.: Expression of tissue inhibitors of
metalloproteinases: negative regulators of human glioblastoma invasion
in vivo. *Clin. Exp. Metast.* **13**: 57-62, 1995.

107\. Dhawan, S., Weeks, B. S., Soderland, C., Schnaper, H. W., Toro, L.
A., Asthana, S. P., Hewlett, I. K., **Stetler-Stevenson, W. G.**,
Yamada, S. S., Yamada, K. M., and Meltzer, M. S.: HIV-1 infection alters
monocyte interactions with endothelial cells. *J. Immunol.* **154**:
422-432, 1995.

108\. Casasco, A., Casasco, M., Reguzzoni, M., Calligaro, A., Tateo, S.,
**Stetler-Stevenson, W. G.**, and Liotta, L. A.: Occurrence and
distribution of matrix metalloproteinase-2-immunoreactivity in human
embryonic tissues. *Eur. J. Histochem.* **39**: 31-38, 1995.

109\. Bergmann, U., Tuuttila, A., **Stetler-Stevenson, W. G.**, and
Tryggvason, K.: Autolytic activation of recombinant human 72 kilodalton
type IV collagenase. *Biochemistry* **34**: 2819-2825, 1995.

110\. Corcoran, M. L. and **Stetler-Stevenson, W. G.**: Tissue inhibitor
of metalloproteinase-2 stimulates fibroblast proliferation via a
cAMP-dependent mechanism. *J. Biol. Chem.* **270**: 13453-13459, 1995.

111\. Emmert-Buck, M. R., Emonard, H. P., Corcoran, M. L., Krutzsch, H.
C., Foidart, J.-M., and **Stetler-Stevenson, W. G.**: Cell surface
binding of TIMP-2 and pro-MMP-2/TIMP-2 complex. *FEBS Lett.* **364**:
28-32, 1995.

112\. **Stetler-Stevenson, W. G.**: Progelatinase A activation during
tumor cell invasion. *Invas. Metast.* **14**: 259-268, 1995.

113\. Kawamata, H., Kameyama, S., Kawai, K., Tanaka, Y., Nan, L., Barch,
D. H., **Stetler-Stevenson, W. G.**, and Oyasu, R.: Marked acceleration
of the metastatic phenotype of a rat bladder carcinoma cell line by the
expression of human gelatinase A. *Int. J. Cancer* **63**: 568-575,
1995.

114\. Saxena, A., Robertson, J. T., Kufta, C., **Stetler-Stevenson, W.
G.**, and Ali, I. U.: Increased expression of gelatinase A and TIMP-2 in
primary human glioblastomas. *Int. J. Oncol.* **7**: 469-473, 1995.

115\. Kawamata, H., Kawai, K., Kameyama, S., Johnson, M. D.,
**Stetler-Stevenson, W. G.**, and Oyasu, R.: Over-expression of tissue
inhibitor of matrix metalloproteinases (TIMP1 and TIMP2) suppresses
extravasation of pulmonary metastasis of a rat bladder carcinoma. *Int.
J. Cancer* **63**: 680-687, 1995.

116\. Rosenberg, G. A., Estrada, E. Y., Dencoff, J. E., and
**Stetler-Stevenson, W. G.**: TNF-a-induced gelatinase B causes delayed
opening of the blood-brain barrier: An expanded therapeutic window.
*Brain Res.* **703**: 151-155, 1995.

117\. Onisto, M., Riccio, M. P., Scannapieco, P., Caenazzo, C., Griggio,
L., Spina, M., **Stetler-Stevenson, W. G.**, and Garbisa, S.: Gelatinase
A/TIMP-2 imbalance in lymph-node-positive breast carcinomas, as measured
by RT-PCR. *Int. J. Cancer* **63**: 621-626, 1995.

118\. Zeng, Z.-S., Cohen, A. M., Zhang, Z.-F., **Stetler-Stevenson, W.
G.**, and Guillem, J. G.: Elevated tissue inhibitor of
metalloproteinase-1 (TIMP-1) RNA in colorectal cancer stroma correlates
with lymph node and distant metastases. *J. Clin. Cancer Res.* **1**:
899-906, 1995.

119\. Rao, V. II, Bridge, J. A., Neff, J. R., Schaefer, G. B., Buehler,
B. A., Viswanatha, J. K., Gokaslan, Z. L., Pollock, R. F., Nicolson, G.
L., Yamamoto, M., **Stetler-Stevenson, W. G.**, Sawaya, R., and Rao, J.
S.: Expression of 72-kDa and 92-kDa type IV collagenases from human
giant cell tumor of bone. *Clin. Exp. Metastasis* **13**: 420-426, 1995.

120\. Rao, J. S., Yamamoto, M., Mohanam, S., Gokaslan, Z. L., Fuller, G.
N., **Stetler-Stevenson, W. G.**, Rao, V. II, Liotta, L. A., Nicolson,
G. L., and Sawaya, R.: Expression and localization and 92-kDa type IV
collagenase in human astrocytomas in vivo. *Clin. Exp. Metastasis*
**14**: 12-18, 1996.

121\. Sun, Y., Kim, H., Parker, M., **Stetler-Stevenson, W. G.**, and
Colburn, N. H.: Lack of reversion of tumor cell phenotype by over
expression of TIMP-3 in mouse JB6 tumor cells: Identification of a
transfectant with increased tumorigenicity and invasiveness. *Anticancer
Res.* **16**: 1-8, 1996.

122\. Sawaya, R., Yamamoto, M., Gokaslan, Z. L., **Stetler-Stevenson, W.
G.**, Mohanam, S., Fuller, G. N., McCutcheon, I. E., Nicolson, G. L.,
and Rao, J. S.: Expression and localization of 72-kDa type IV
collagenase in human malignant gliomas in vivo. *Clin. Exp. Metastasis*
**14**: 35-42, 1996.

123\. Ray, J. M. and **Stetler-Stevenson, W. G.**: Matrix
metalloproteinases and malignant disease: recent developments. *Exp.
Opin. Invest. Drugs* **5**: 323-335, 1996.

124\. Hewitt, R. E., Corcoran, M. L., and **Stetler-Stevenson, W. G.**:
The activation, expression and function of gelatinase A (MMP-2). *Trends
Glycosci. Glycotech.* **8**: 23-36, 1996.

125\. Panchenko, M. V., **Stetler-Stevenson, W. G.**, Trubetskoy, O. V.,
Gacheru, S. N., and Kagan, H. M.: Metalloproteinase activity secreted by
fibrogenic cells in the processing of prolysyl oxidase potential role of
procollagen C-proteinase. *J. Biol. Chem.* **271**: 7113-7119, 1996.

126\. Li, Z., Li, L., Zielke, R., Cheng, L., Zia., R., Crow, M.T.,
**Stetler-Stevenson, W. G.**, Froelich, J., Lakatta, E. G.: Increased
Expression of 72-kd Type IV Collagenase (MMP-2) in Human Aortic
Atherosclerotic Lesions. *Amer. J. Pathol.* **148**: 121-128, 1996.

127\. **Stetler-Stevenson, W. G.**: The dynamics of matrix turnover
during pathologic remodeling of the extracellular matrix. *Am. J.
Pathol.* **148**: 1345-1350, 1996.

128\. Brooks, P. C., Strömblad, S., Sanders, L. C., von Schalscha, T.
L., Aimes, R. T., **Stetler-Stevenson, W. G.**, Quigley, J. P., and
Cheresh, D. A.: Localization of matrix metalloproteinase MMP-2 to the
surface of invasive cells by interaction with integrin v3. *Cell*
**85**: 683-693, 1996.

129\. Celerin, M., Ray, J.M., Schisler, N., Day, A.W.,
**Stetler-Stevenson, W. G.** and Laudenbach, D.E.: Fungal fimbriae are
composed of collagen. *EMBO J.* **15**: 4445-4453, 1996.

130\. Sato, H., Takino, T., Kinoshita, T., Imai, K., Okada, Y.,
**Stetler-Stevenson, W. G.** and Seiki, M.: Cell surface binding and
activation of gelatinase A induced by expression of
membrane-type-1-matrix metalloproteinase. *FEBS Lett.* **385**: 238-240,
1996

131\. Hayashi, T., **Stetler-Stevenson, W. G.**, Fleming, MV, Fishback,
N., Koss, M. N., Liotta, L. A., Ferrans, V. J., Travis, W. D.:
Immunohistochemical study of metalloproteinases and their tissue
inhibitors in lungs of patients with diffuse alveolar damage and
idiopathic pulmonary fibrosis. *Am. J. Pathol.* **149**: 1241-1256,
1996.

132\. Zafarullah, M., Su, S., Martel-Pelletier, J., DiBattista, J. A.,
Costello, B. G., **Stetler-Stevenson, W. G.**: Tissue Inhibitor of
metalloproteinase-2 (TIMP-2) mRNA is constitutively expressed in bovine,
human normal and osteoarthritic chondrocytes. *J. Cell. Biochem.*
**60**: 211-217, 1996

133\. **Stetler-Stevenson, W. G.**, Hewitt, R., and Corcoran, M.: Matrix
metalloproteinases and tumor invasion: From correlation and causality to
the clinic. *Semin. Cancer Biol.* **7**: 147-154, 1996.

134\. Anderson, S. S., Wu, K., Nagase, H., **Stetler-Stevenson, W. G.**,
Kim, Y. and Tsilibary, E. C.: Effect of matrix glycation on expression
of type IV collagen, MMP-2, MMP-9 and TIMP-1 by human mesangial cells.
*Cell Adhesion Commun.* **4**: 7-19, 1996.

135\. Schnapper, H.W., Kopp, J.B., Poncelet, A. C., Hubchak, S.C.,
**Stetler-Stevenson, W. G.**, Klotman, P.E. and Kleinman, H.K.:
Increased expression of extracellular matrix proteins and decreased
expression of matrix proteases after serial passage of glomerular
mesangial cells. *J. Cell Sci.* **109**: 2521-2528, 1996.

136\. Giannelli, G., Brassard, J., Foti, C., **Stetler-Stevenson, W.
G.**, Schiraldi, O., and Quaranta, V.: Altered expression of basement
membrane proteins and their integrin receptors in lichen planus:
Possible pathogenetic role of gelatinases A and B. *Lab. Invest.*
**74**: 1091-1104, 1996.

137\. Schoedel, K. E., Greco, M. A., **Stetler-Stevenson, W. G.**,
Ohori, N. P., Goswami, S., Present, D., and Steiner, G. C.: Expression
of metalloproteinases and tissue inhibitors of metalloproteinases in
giant cell tumor of bone: An immunohistochemical study with clinical
correlation. *Human Pathol.* **27**: 1144-1148, 1996.

138\. Guedez, L., Lim, M.S., & **Stetler-Stevenson, W. G.**: The role of
metalloproteinases and their inhibitors in hematological disorders.
*Crit. Rev. Oncog.* **7**: 205-225, 1996.

139\. Stetler-Stevenson, M., Mansoor, A., Lim, M., Fukushima, P., Kerhl,
J., Marti, J., Ptaszynski, K., Wang, J., and **Stetler-Stevenson, W.
G.**: Expression of matrix metalloproteinases (gelatinase A and
gelatinase B) and tissue inhibitors of metalloproteinases (TIMPs) in
reactive and neoplastic lymphoid cells. *Blood* **89**: 1708-1715, 1997.

140\. Oliver, G. W., Leferson, J. D., **Stetler-Stevenson, W .G.** and
Kleiner, D. E.: Quantitative Reverse Zymography: Analysis of Picogram
Amounts of Metalloproteinase Inhibitors Using Gelatinase A and B Reverse
Zymograms. *Anal. Biochem.* **244**: 161-166, 1997.

141\. Yu, A. E., Hewitt, R. E., Kleiner, D. E. and **Stetler-Stevenson,
W. G.**: Molecular regulation of cellular invasion - role of gelatinase
A and TIMP-2. *Biochem. Cell. Biol.* **74**: 823-831, 1997.

142\. Wu, A. J., Lafrenie, R. M., Park, Ch. Apinhasmit, W., Chen, Z. J.,
Birkedal-Hansen, H., Yamada, K. M., **Stetler-Stevenson, W. G.**, and
Baum, B.J.: Modulation of MMP-2 (Gelatinase A) and MMP-9 (Gelatinase B)
by Interferon-α in a Human Salivary Gland Cell Line. *J. Cell. Physiol.*
**171**: 117-124, 1997.

143\. Giannelli, G., Falk-Marzillier, J., Schiraldi, O.,
**Stetler-Stevenson, W. G.**, and Quaranta, V.: Induction of Cell
Migration by Matrix Metalloproteinase-2 Cleavage of Laminin-5. *Science*
**277**: 225-228, 1997.

144\. Hayashi, T., Rush, W. L., Travis. W. D., Liotta, L. A.,
**Stetler-Stevenson, W. G.**, Ferrans, V. J.: Immunohistochemical study
of matrix metalloproteinases and their tissue inhibitors in pulmonary
Langerhans' cell granulomatosis. *Arch. Pathol. Lab. Med.* **121**:
930-937, 1997.

145\. Walther, M. M., Kleiner, D. E., Lubensky, I. A., Pozzatti, R.,
Nyguen, T., Gnarra, J. R., Hurley, K., Venzon, D., Linehan, W. M.,
**Stetler-Stevenson, W. G.**: Progelatinase A mRNA expression in cell
lines derived from tumors in patients with metastatic renal cell
carcinoma correlates inversely with survival. *Urology* **50**: 295-301,
1997.

146\. Powe, D. G., Brough, J. L., Carter, G. I., Bailey, E. M.,
**Stetler-Stevenson, W. G.**, Turner, D. R., and Hewitt, R. E.: TIMP-3
mRNA expression is regionally increased in moderately and poorly
differentiated colorectal adenocarcinoma. *Br. J. Cancer* **75**:
1678-1683, 1997.

147\. Hayashi, T., Fleming, M.V., **Stetler-Stevenson, W. G.**, Liotta,
L.A., Moss, J., Ferrans, V.J., and Travis, W. D.: Immunohistochemical
Study of Matrix Metalloproteinases (MMPs) and Their Tissue Inhibitors of
(TIMPs) in Pulmonary Lymphangioleiomyomatosis (LAM). *Human Path.*
**28**: 1071-1078, 1997.

148\. Jenkins, G.M., Crow, M.T., Bilato, C., Gluzband, Y., Ryu, W.S.,
Li, Z.H., **Stetler-Stevenson, W. G.**, Nater, C., Froehlich, J.P.,
Lakatta, E.G., Cheng, L.: Increased expression of membrane-type matrix
metalloproteinase and preferential localization of matrix
metalloproteinase-2 to the neointima of balloon-injured rat carotid
arteries. *Circulation* **97**: 82-90, 1998.

149\. Seftor, R.E.B., Seftor, E.A., De Larco, J.E., Kleiner, D.E.,
Leferson J., **Stetler-Stevenson, W. G.,** McNamara, T.F., Golub, L.M.,
Hendrix, M.J.C.: Chemically modified tetracyclines inhibit human
melanoma cell invasion and metastasis. *Clin. Exp. Metastasis* **16**:
217-225, 1998.

150\. Valente, P., Fassina, G., Melchiori, A., Masiello, L., Cilli, M.,
Vacca, A., Onisto, M., Santi, L., **Stetler-Stevenson, W. G.**, Albini
A.: TIMP-2 over-expression reduces invasion and angiogenesis and
protects B16F10 melanoma cells from apoptosis. *Int. J. Cancer* **75**:
246-253, 1998.

151\. Zuo, J., Ferguson, T.A., Hernandez, Y.J. , **Stetler-Stevenson, W.
G.** and Muir, D.: Neuronal matrix metalloproteinase-2 degrades and
inactivates a neurite-inhibiting chondroitin sulfate proteoglycan. *J.
Neurosci*. **18**: 5203-5211, 1998.

152\. Ota, K., **Stetler-Stevenson, W. G.**, Yang, Q.W., Kumar, A.,
Wada, J., Kashihara, N., Wallner, E.I., and Kanwar, Y.S.: Cloning of
murine embrane-type-1-matrix metalloproteinase (MT-1-MMP) and its
metanephric developmental regulation with respect to MMP-2 and its
inhibitor. *Kidney Int.* **54**: 131-142, 1998.

153\. Cheng, L., Mantile, G., Pauly, R., Nater, C., Felici, A.,
Monticone, R., Bilato, C., Gluzband, Y., Crow, M.T.,
**Stetler-Stevenson, W. G.** and Capograzzi, M.: Adenovirus-Mediated
Gene Transfer of the Human Tissue Inhibitor Of Metalloproteinase-2
Blocks Vascular Smooth Muscle Cell Invasiveness In Vitro and Modulates
Neointimal Development In Vivo. *Circulation* **98**: 2195-2201, 1998.

154\. Guedez, L., **Stetler-Stevenson, W. G.**, Wolff, L., Wang, J.,
Fukushima, P., Mansoor, A., and Stetler-Stevenson, M.: In Vitro
suppression of Programmed Cell death of B Cells by Tissue Inhibitor of
Metalloproteinases-1. *J. Clin. Invest.* **102**: 2002-2010, 1998

155\. Segura, A.M., Luna, R.E., Horiba, K., **Stetler-Stevenson, W.
G.**, McAllister, H.A., Jr., Willerson, J.T., AND Ferrans, V.J.:
Immunohistochemistry of matrix metalloproteinases and their inhibitors
in thoracic aortic aneurysms and aortic valves of patients with
Marfan\'s syndrome. *Circulation* **10**: II331-7, 1998.

156\. Elliot, S.J., Striker, L.J., **Stetler-Stevenson, W. G.**, Jacot,
T.A. and Striker, G.E: Pentosan polysulfate decreases proliferation and
net extracellular matrix production in mouse mesangial cells. *J. Am.
Soc. Nephrol.* **10**: 62-68, 1999.

157\. **Stetler-Stevenson, W. G.**: Matrix metalloproteinases in
angiogenesis: a moving target for therapeutic intervention. *J. Clin.
Invest.* **103**:1237-1241, 1999

158\. Marchetti, C., Cornaglia, I., Casasco, A., Bernasconi, G.,
Baciliero, U. and **Stetler-Stevenson, W. G.**: Immunolocalization of
gelatinase-A (matrix metalloproteinase-2) in damaged human
temporomandibular joint discs. *Arch. Oral Biol.* **44**: 297-304, 1999.

159\. Kleiner, D. E. and **Stetler-Stevenson, W. G.**: Matrix
metalloproteinases and metastasis. *Cancer Chemother. Pharmacol.*
**43**: S42-S51, 1999.

160\. Wingfield, P. T., Sax, J. K., Stahl, S. J., Kaufman, J., Palmer,
I., Chung, V., Corcoran, M. L., Kleiner, D. E. and **Stetler-Stevenson,
W. G.**: Biophysical and Functional Characterization of Full-length,
Recombinant Human Tissue Inhibitor of Metalloproteinases-2 (TIMP-2)
Produced in Escherichia coli. *J. Biol. Chem.* **274**: 21362-21368,
1999.

161\. O'Reily, M. S., Wiederschain, D., **Stetler-Stevenson, W. G.**,
Folkman, J., and Moses, M.A.: Regulation of Angiostatin Production by
Matrix Metalloproteinase-2 in a Model of Concomitant Resistance. *J.
Biol. Chem.* **274**: 29568-29571, 1999.

162\. Lim, M.S., Guedez, L., **Stetler-Stevenson, W. G.**,
Stetler-Stevenson, M.: Tissue inhibitor of metalloproteinase-2 induces
apoptosis in human T

lymphocytes. *Ann. N. Y. Acad. Sci.* **878**: 522-523, 1999.

163\. Koochekpour, S., Jeffers, M., Wang, P.H., Gong, C., Taylor, G.A.,
Roessler, L.M., Stearman, R., Vasselli, J.R., **Stetler-Stevenson, W.
G.**, Kaelin, W.G. Jr., Linehan, W.M., Klausner, R.D., Gnarra, J.R., and
Vande Woude, G.F.: The von Hippel-Lindau tumor suppressor gene inhibits
hepatocyte growth factor/scatter factor-induced invasion and branching
morphogenesis in renal carcinoma cells. *Mol. Cell Biol.* **19**:
5902-12, 1999.

164\. Galateau-Salle, F. B., Luna, R. E., Horiba, K., Sheppard, M. N.,
Hayashi, T., Fleming, M. V., Colby, T. V., Bennett, W., Harris, C. C.,
**Stetler-Stevenson, W. G.**, Liotta, L., Ferrans, V. and J.Travis, W.
D.: Matrix metalloproteinases and tissue inhibitors of
metalloproteinases in bronchial squamous preinvasive lesions. *Human
Path.* **31**: 296-305, 2000.

165\. Elliot, S. J., Striker, L. J., Connor, E., **Stetler-Stevenson, W.
G.**, Blagg, C. R. and Striker, G. E.: Pentosan polysulfate decreases
proliferation and extracellular matrix deposition by vascular smooth
muscle cells isolated from failed hemodialysis access grafts. *Clin.
Nephrol.* **54**: 121-127, 2000.

166\. Lenz, O., Elliot, S. J. and **Stetler-Stevenson, W. G.**: Matrix
metalloproteinases in renal development and disease. *J. Amer. Soc.
Nephrol.* **11**: 574-581, 2000.

167\. Taraboletti, G., Sonzogni, L., Vergani, V., Hosseini, G., Ceruti,
R., Ghilardi, C., Bastone, A.,, Toschi, E., Borsotti, P., Scanziani, E.,
Giavazzi, R., Pepper, M. S., **Stetler-Stevenson, W. G.** and Bani, M.
R.: Posttranscriptional stimulation of endothelial cell matrix
metalloproteinases 2 and 1 by endothelioma cells. *Exp. Cell Res.*
**258**: 384-394, 2000.

168\. Hewitt, R.E., Brown, K.E., Corcoran, M. and **Stetler-Stevenson,
W. G.**: Increased expression of tissue inhibitor of metalloproteinases
type 1 (TIMP-1) in a more tumorigenic colon cancer cell line. *J.
Pathol.* **192**: 455-459, 2000.

169\. Hewitt, R.E., McMarlin, A., Kleiner, D., Wersto, R., Martin, P.,
Tsokos, M., Stamp, G.W., **Stetler-Stevenson, W. G.**: Validation of a
model of colon cancer progression. *J. Pathol.* **192**:446-454, 2000.

170\. Birkedal-Hansen, B., Pavelic, Z.P., Gluckman, J. L., Stambrook,
P., Li, Y.-Q. and **Stetler-Stevenson, W. G.**: MMP and TIMP Gene
Expression in Head and Neck Squamous Cell Carcinoma and Adjacent
Tissues*. Oral Dis.* **6**: 376-382, 2000.

171\. Holten-Andersen, M. N., Stephens, R. W., Nielsen, H. J., Murphy
G., Christensen, I. J., **Stetler-Stevenson, W**. and Brünner, N. : High
Preoperative Plasma Tissue Inhibitor of Metalloproteinase-1 Levels Are
Associated with Short Survival of Patients with Colorectal Cancer.
*Clin. Cancer Res.* **6**: 4292-4299, 2000.

172\. Hoegy, S.E., Oh, H.-R., Corcoran, M.L., and **Stetler-Stevenson,
W. G.**: Tissue Inhibitor of Metalloproteinases-2 (TIMP-2) Suppresses
TKR-Growth Factor Signaling Independent of Metalloproteinase Inhibition.
*J. Biol. Chem.* **276**: 3203-3214, 2001.

173\. Guedez, L., Mansoor, A., Birkedal-Hansen, B., Lim, M.S.,
Fukushima, P., Venzon, D., **Stetler-Stevenson, W. G.** and
Stetler-Stevenson, M.: TIMP-1 Regulation of IL-10 in B Cell
Differentiation and Lymphomagenesis. *Blood* **97**: 1796-1802, 2001.

174\. **Stetler-Stevenson, W. G.**: The Role of Matrix
Metalloproteinases in Tumor Invasion, Metastasis and Angiogenesis.
*Surg. Oncol. Clin. N. Amer.* **10**: 383-392, 2001.

175\. Guedez, L., McMarlin, A. J., Kingma, D. W., Bennett, T. A.,
Stetler-Stevenson, M. and **Stetler-Stevenson, W. G.**: Tissue Inhibitor
of Metalloproteinases (TIMP)-1 Alters The Tumorigenicity of Burkitt\'s
Lymphoma Via Both Growth Promoting and Dominant Anti-Angiogenic Effects.
*Amer. J. Pathol.* **158**: 1207-1215, 2001.

176\. Vergani, V., Garofalo, A., Bani, M.R., Borsotti, P., Parker, M.P.,
Drudis, T., Mazzarol, G., Viale, G., Giavazzi, R., **Stetler-Stevenson,
W. G.** and Taraboletti, G.: Inhibition of matrix metalloproteinases by
over-expression of tissue inhibitor of metalloproteinase-2 inhibits the
growth of experimental hemangiomas. *Int. J. Cancer* **91**: 241-247,
2001.

177\. Alpler, Ö., Bergmann-Leitner, S., Bennett, T. Hacker, N.F.,
Stromberg, K. and **Stetler-Stevenson, W. G.**: EGFR-Antisense In
Ovarian Carcinoma Cells Reduces Integrin and Metalloproteinase-Mediated
Attachment/Migration. *J. Natl. Cancer Inst.* **93**: 1375-1384, 2001.

178\. Seftor R.E.B., Seftor, E. A., Meltzer, P. S., Gardner, L.M.G.,
Biban, M., Koshikawa, N., Schateemen, G. C., **Stetler-Stevenson, W.
G.**, Quaranta, V. and Hendrix, M.J.C. Cooperative Interactions of
Laminin -5, MMP-2 and MT-1-MMP are Required for Mimicry of Embryonic
Vasculogenesis by Aggressive Melanoma. *Cancer Res.* **61**: 6322-6327,
2001.

179. Shankavaram, U. T., Lai, W.-C., Netzel-Arnett, S., Mangan, P. R.,
     Ardans, J.A., Caterina, N., **Stetler-Stevenson, W. G.**,
     Birkedal-Hansen, H. and Wahl, L.M: Monocyte Membrane Type I-Matrix
     Metalloproteinase: Prostaglandin-Dependent Regulation and Role in
     MMP-2 Activation. *J. Biol. Chem.* **276**: 19027-19032, 2001.

180. **Stetler-Stevenson, W. G.** and Yu, A.: Proteases in invasion:
     matrix metalloproteinases. *Sem. Cancer Biol.* **11**: 143-153,
     2001.

181. **M**atsui, K., Takano, Y., Yu, Z.X., **Stetler-Stevenson, W. G.**,
     Travis, W. D., and Ferrans, V. J.: Immunohistochemical study of
     endothelin-1 and matrix metalloproteinases in plexogenic pulmonary
     arteriopathy. *Pathol. Res. Pract.* **198**: 403-412, 2002.

182. Gonzalez, A. A., Segura, A. M., Horiba, K., Qian, S., Yu, Z. X.,
     **Stetler-Stevenson, W. G.**, McAllister, H. A., Jr., and
     Ferrans, V. J.: Matrix metalloproteinases and their tissue
     inhibitors in the lesions of cardiac and pulmonary sarcoidosis: an
     immunohistochemical study. *Hum. Pathol.* **33**: 1158-1164, 2002.

183. Karamessinis, P. M., Tzinia, A. K., Kitsiou, P. V.,
     **Stetler-Stevenson, W. G.**, Michael, A. F., Zhou, B.,
     Margaritis, L. H. and Tsilibary, E. C.: Proximal tubular epithelial
     cell integrins respond to high glucose by altered cell-matrix
     interactiona dn defferentially regulate matrixin expression. *Lab.
     Invest.* **82**: 1081-1093, 2002.

184. Martinez, A., Vos, M., Guedez, L., Kaur, G., Chen, Z., Garayoa, M.,
     Pio, R., Moody, T., **Stetler-Stevenson, W. G.**, Kelinman, H. K.
     and Cuttitta, F.: The effects of adrenomedullin overexpression in
     breast tumor cells. *J. Natl. Cancer Inst.* **94**: 1226-1237,
     2002.

185. Guedez, L., Rivera, A. M., Salloum, R., Miller, M. L.,
     Diegmueller, J. J., Bungay, P. M. and **Stetler-Stevenson, W. G.**:
     Quantitative Assessment of Angiogenic Responses by the Directed *in
     Vivo* Angiogenesis Assay. *Amer. J. Pathol.* **162**: 1431-1439,
     2003.

186. Seo, D.-W., Li, H., Guedez, L., Wingfield, P.T., Diaz, T., Salloum,
     R., Wei, B. and **Stetler-Stevenson, W. G.**: TIMP-2 Mediated
     Inhibition of Angiogenesis: An MMP-Independent Mechanism. *Cell*
     114: 171-180, 2003.

187. Tester, A. M., Waltham, M., Oh, S.-J., Bae, S.-N., Bills, M. M.,
     Walker, E. C., Kern, F. G., **Stetler-Stevenson, W. G.**,
     Lippman, M. E., and Thompson, E. W.: Pro-Matrix Metalloproteinase-2
     Transfection Increases Orthotopic Primary Growth and Experimental
     Metastasis of MDA-MB-231 Human Breast Cancer Cells in Nude Mice.
     *Cancer Research* 64: 652-658, 2004.

188. McDonald, D. M., Teicher, B. A., **Stetler-Stevenson, W.**,
     Ng, S. S. W., Figg, W. D., Folkman, J., Hanahan, D., Auerback, R.,
     O'Reilly, M., Herbst, R., Cheresh, D., Gordon, M., Eggermont, A.
     and Libutti, S. K.: Report from the Society for Biological Therapy
     and Vascular Biology Faculty of the NCI Workshp On Angiogenesis
     Monitoring. *J. Immunother.* 27: 161-175, 2004.

189\. Feldman, A.L., **Stetler-Stevenson, W. G.**, Costouros, N. G.,
Knezevic, V., Quian, M., Alexander, H. R., Lorang, D., Hewitt, S. M.,
Miller, M. S. and Libutti, S. K.: Identifying gene expression patterns
associated with the host response to tissue inhibitor of
metalloproteinase-2. *Cancer Res.*, 64: 4481-4486, 2004.

190\. Adair, J. C., Charlie, J., Dencoff, J. E., Kaye, J. A., Quinn, J.
F., Camicioloi, R. M., **Stetler-Stevenson, W. G.**, and Rosenberg, G.
A.: Measurement of Gelatinase B (MMP-9) in the Cerebrospinal Fluid of
Patients with Vascular Dementia and Alzheimer Disease. *Stroke* 35:
259-162, 2004.

191\. Haviernik, P., Lahoda, C., Bradley, H. L., Hawley, T. S.,
Ramezani, A., Hawley, R. G., Stetler-Stevenson, M., **Stetler-Stevenson,
W. G.** and Bunting, K. D.: Tissue inhibitor of matrix
metalloproteinase-1 overexpression in M1 myeloblasts impairs
IL-6-induced differentiation. *Oncogene* **23:** 9212-9, 2004.

192\. Martinez, A., Zudaire, E., Portal-Nunez, S., Guedez, L., Libutti,
S. K., Stetler-Stevenson, W. G. and Cuttitta, F.: Proadrenomedullin
NH2-terminal 20 peptide is a potent angiogenic factor, and its
inhibition results in reduction of tumor growth. *Cancer Research*
**64:** 6489-94, 2004.

193\. Oh, J., Seo, D. W., Diaz, T., Wei, B., Ward, Y., Ray, J. M.,
Morioka, Y., Shi, S., Kitayama, H., Takahashi, C., Noda, M. and
Stetler-Stevenson, W. G.: Tissue inhibitors of metalloproteinase 2
inhibits endothelial cell migration through increased expression of
RECK. *Cancer Research* **64:** 9062-9, 2004.

194\. Tester, A. M., Waltham, M., Oh, S. J., Bae, S. N., Bills, M. M.,
Walker, E. C., Kern, F. G., Stetler-Stevenson, W. G., Lippman, M. E. and
Thompson, E. W.: Pro-matrix metalloproteinase-2 transfection increases
orthotopic primary growth and experimental metastasis of MDA-MB-231
human breast cancer cells in nude mice. *Cancer Research* **64:** 652-8,
2004.

195\. Martinez, A., Oh, H.R., Unsworth, E.J., Bregonzio, C., Saavedra,
J.M., Stetler-Stevenson, W.G., Cuttitta, F.: Matrix metalloproteinase-2
cleavage of adrenomedullin produces a vasoconstrictor out of a
vasodilator. *Biochem J.* **383**(Pt. 3):413-8, 2004.

196\. Bianco, C., Strizzi, L., Ebert, A., Chang, C., Rehman, A.,
Normanno, N., Guedez, L., Salloum, R., Ginsburg, E., Sun, Y., Khan, N.,
Hirota, M., Wallace-Jones, B., Wechselberger, C., Vonderhaar, B. K.,
Tosato, G., **Stetler-Stevenson, W. G.**, Sanicola, M. and Salomon, D.
S.: Role of human cripto-1 in tumor angiogenesis. *Journal of the
National Cancer Institute* **97:** 132-41, 2005.

197\. Guedez, L., Martinez, A., Zhao, S., Vivero, A., Pittaluga, S.,
Stetler-Stevenson, M., Raffeld, M. and **Stetler-Stevenson, W. G.:**
Tissue inhibitor of metalloproteinase 1 (TIMP-1) promotes plasmablastic
differentiation of a Burkitt lymphoma cell line: implications in the
pathogenesis of plasmacytic/plasmablastic tumors. *Blood* **105:**
1660-8, 2005.

198\. Wang, T., Ward, Y., Tian, L., Lake, R., Guedez, L.,
**Stetler-Stevenson, W.G**., and Kelly, K.: CD97, an adhesion receptor
on inflammatory cells, stimulates angiogenesis through binding integrin
counterreceptors on endothelial cells. *Blood* **105**(7): 2836-44,
2005.

199. Larsen, M.B., Stephens, R.W., Brunner, N., Nielsen, H.J.,
     Engelholm, L.H., Christensen, I.J., **Stetler-Stevenson, W.G.**,
     Hoyer-Hansen, G.: Quantification of tissue inhibitor of
     metalloproteinases 2 in plasma from healthy donors and cancer
     patients. Scand J Immunol. **61**(5): 449-60, 2005.

200. **Stetler-Stevenson, W.G.**, and Seo, D.-W.: TIMP-2: an endogenous
     inhibitor of angiogenesis. *Trends Mol Med.* **11**(3):97-103,
     2005.

201. Stuelten, C.H., DaCosta, Byfield, S., Arany, P.R., Karpova, T.S.,
     **Stetler-Stevenson, W.G.**, Roberts, A.B.: Breast cancer cells
     induce stromal fibroblasts to express MMP-9 via secretion of
     TNF-alpha and TGF-beta. *J Cell Sci.* **118** (Pt 10): 2143-53,
     2005.

202. Seo, D.-W., Li, H., Qu, C.-K., Oh, J., Kim, Y.-S., Diaz, T., Wei,
     B., Han, J.-W., and **Stetler-Stevenson, W. G.**: Shp-1 Mediates
     the Antiproliferative Activity of Tissue Inhibitor of
     Metalloproteinase-2 in Human Microvascular Endothelial Cells. *J.
     Biol. Chem.* **281**: 3711-3721, 2006.

203. Oh, J., Diaz, T., Wei, B., Chang, H., Noda, M. and
     **Stetler-Stevenson, W. G.**: TIMP-2 upregulates RECK expression
     via dephosphorylation of paxillin tyrosine residues 31 and 118.
     *Oncogene*, 25:3230-4234, 2006.

204. Khakoo, A. Y., Pati, S., Anderson, S. A., Reid, W., Elshal, M. F.,
     Rovira, I., Nguyen, A., Malide, D., Combs, C. A., Hall, G., Zhang,
     J., Raffeld, M., Rogers, T. B., **Stetler-Stevenson, W. G.**,
     Frank, J. A., Reitz, M. and Finkel, T.: Human Mesenchymal Stem
     Cells Exert Potent Anti-Tumorigenic Effects in a Model of Kaposi's
     Sarcoma. *J. Experimental Medicine*, **203**: 1235-1247, 2006.

205. Chang, H., Lee, J., Poo, H., Noda, M., Diaz, T., Wei, B.,
     Stetler-Stevenson, W. G. and Oh, J. : TIMP-2 promotes cell
     spreading and adhesion via upregulation of Rap1 signaling.
     *Biochem. Biophys. Res. Comm.* **345**: 1201-1206, 2006.

**Book Chapters:**

l\. Veis, A., **Stetler-Stevenson, W. G.**, Takagi, Y., Sabsay, B., and
Fullerton, R.: In Veis, A. (Ed.): The Chemistry and Biology of
Mineralized Connective Tissues. New York, Elsevier/North Holland, 198l.

2\. Liotta, L. A. and **Stetler-Stevenson, W. G.**: Principles of
molecular cell biology of cancer: Cancer metastasis. In DeVita, V. T.,
Jr., Hellman, S., and Rosenberg, S. A. (Eds.): Cancer: Principles and
Practice of Oncology, Vol. l, 3rd Ed. Philadelphia, J. B. Lippincott
Co., 1989, pp. 98-ll5.

3\. Garbisa, S., D\'Errico, A., Grigioni, W. F., Biagini, G., Caenazzo,
C., Fastelli, G., **Stetler-Stevenson, W. G.**, and Liotta, L. A.: Type
IV collagenase augmentation associated with colorectal and gastric
cancer progression. In Harris, C. C. and Liotta, L. A. (Eds.): Genetic
Mechanisms in Carcinogenesis and Tumor Progression. UCLA Symposia on
Molecular and Cellular Biology, New Series, Vol. ll4. New York,
Wiley-Liss, 1990, pp. 203-2l2.

4\. **Stetler-Stevenson, W. G.**, Kreck, M. L., and Talano, J. A.:
Assaying type IV collagenase activity using \[3H\]-pepsinized human
placental type IV collagen, NET-93l. NEN/Dupont Biotechnology Update
5:54-55, 1990.

5\. **Stetler-Stevenson, W. G.**, Liotta, L. A., and Brown, P. D.: Role
of type IV collagenases in human breast cancer. In Dickson, R. B. and
Lippman, M. E. (Eds.): Genes, Oncogenes, and Hormones: Advances in
Cellular and Molecular Biology of Breast Cancer. Boston, Kluwer Academic
Publ., 1991, pp. 21-41.

6\. Liotta, L. A., Kohn, E. C., Steeg, P. S., and **Stetler-Stevenson,
W. G.**: Molecular biology of metastasis. In Broder, S. (Ed.): Molecular
Foundations in Oncology. Baltimore, Williams & Wilkins, 1991, pp. 57-81.

7\. Castronovo, V., **Stetler-Stevenson, W. G.**, Sobel, M. E., and
Liotta, L. A.: Molecular inhibition of cancer cell invasion and
metastasis. Princess Takamatsu Symposium Proceedings 22:319-337, 1991.

8\. Liotta, L. A., **Stetler-Stevenson, W. G.**, and Steeg, P. S.:
Metastasis suppressor genes. In DeVita, V. T., Jr., Hellman, S., and
Rosenberg, S. A. (Eds.): Important Advances in Oncology, 1992.

9\. Liotta, L. A., **Stetler-Stevenson, W. G.**, and Steeg, P. S.:
Invasion and metastasis. In Holland, J. F., Frei, E., III, Bast, R. C.,
Jr., Kufe, D. W., Morton, D. L., and Weichselbaum, R. R. (Eds.): Cancer
Medicine, 3rd Ed. Philadelphia, Lea & Febiger, 1993, pp. 138-153.

10\. Kleiner, D. E., Jr., Margulies, I. M. K., and **Stetler-Stevenson,
W. G.**: Proteinase assays/zymography. In Griffiths, J. B., Doyle, A.,
and Newell, D. G. (Eds.): Cell & Tissue Culture: Laboratory Procedures.
S. Wiley and Sons , 1992.

11\. Ray, J. M. and **Stetler-Stevenson, W. G.**: Gelatinase A and
TIMP-2 alter human melanoma cell adhesion. In Suzuki, M. and Hiwasa, T.
(Eds.): Proteases Involved in Cancer. Proceedings of the Chiba
International Symposium on Cancer. Monduzzi Editore, Bologna, Italy,
1995; pp. 89-95.

12\. Corcoran, M. L., Kleiner, D. E., Jr., and **Stetler-Stevenson, W.
G.**: Regulation of matrix metalloproteinases during extracellular
matrix turnover. In Zderic, S. (Ed.): Muscle, Matrix and Bladder
Function. New York, Plenum Press, 1995, pp151-159.

13\. Corcoran, M. L., Emmert-Buck, M. R., McClanahan, J. L.,
Pelina-Parker, M., and **Stetler-Stevenson, W. G.**: TIMP-2 mediates
cell surface binding of MMP-2. In Suzuki, K. and Bond, J. (Eds.):
Intracellular Protein Catabolism, Plenum Press, New York, 1996, pp.
295-304.

14\. **Stetler-Stevenson, W. G.**: Matrix metalloproteinase inhibitors.
In Teicher, B. (Ed.): Cancer Drug Discovery. Humana Press Inc., Totowa,
NJ, pp241-261, 1996

15\. Corcoran, M. L., Hewitt, R. E., Kleiner, D. E., Jr. and
**Stetler-Stevenson, W. G.**: MMP-2: Expression, activation and
inhibition. Enzyme and Protein 49 (1-3): 7-19, 1996.

16\. **Stetler-Stevenson, W. G.** and Corcoran, M. L.: Tumor
Angiogenesis: functional similarities with tumor invasion. In Goldberg,
I.D. and Rosen, E. M. (Eds.): Regulation of Angiogenesis. Birkhauser
Verlag, Basel, pp 413-418, 1997.

17\. Yu, A. E., Hewitt, R. E., Connor, E. W. and **Stetler-Stevenson, W.
G.**: Matrix Metalloproteinases: Novel Targets for Directed Cancer
Therapy. Drugs & Aging 11 (3): 229-244, 1997.

18\. Yu, A. E., Murphy, A. N., and **Stetler-Stevenson, W. G.**: 72-kDa
Gelatinase (Gelatinase A): Structure, Activation, Regulation, and
Substrate Specificity. In Parks, W.C. and Mecham, R. P. (Eds.): Matrix
Metalloproteinases. Academic Press, San Diego, pp. 85-113, 1998.

19\. **Stetler-Stevenson, W. G.** and Kleiner, D. E., Jr.: Molecular
Biology of Cancer: Molecular Mechanisms of Cancer Invasion and
Metastasis in Cancer Principles and Practice of Oncology, DeVita, V.,
Hellman, S. and Rosenberg, S., eds. Lippincot, William & Wilkins,
Philadelphia, 2001, pp. 123-136.

20. Bennett, T. A. and **Stetler-Stevenson, W. G.**: Matrix
    Metalloproteinases (Matrixins) and Their Inhibitors (TIMPS) in
    Angiogenesis. In Tumor Angiogenesis and Microcirculation,
    Voest, E. E. and DíAmore, P.A., eds. Marcel Dekker, Inc., New York,
    2001, pp. 29-57.

21. Birkedal-Hansen, H., Yamada, S., Windsor, J., Poulsen, A. H., Lyons,
    G., **Stetler-Stevenson, W. G.** and Birkedal-Hansen, B.: Matrix
    Metalloproteinases in *Current Protocols in Cell Biology*, John
    Wiley & Sons, 2002, pp. 10.8.1-10.8.23.

22. **Stetler-Stevenson, W. G.**: Molecular Biology of Cancer: Molecular
    Mechanisms of Cancer Metastasis in *Cancer Principles and Practice
    of Oncology*, DeVita, V., Hellman, S. and Rosenberg, S., eds.
    Lippincot, William & Wilkins, Philadelphia, 2005.

23. **Stetler-Stevenson, W. G.** and Seo, D.-W.: Matrix
    Metalloproteinases in Tumor Progression in Cell Motility in Cancer
    Invasion and Metastsis, Wells, A. ed. Springer, Dordrecht, The
    Netherlands, 2006.

24\. Guedez, L. and **Stetler-Stevenson, W. G.:** THE ROLE OF MATRIX
METALLOPROTEINASES AND THEIR ENDOGENOUS INHIBITORS IN REGULATION OF
TUMOR-ASSOCIATED ANGIOGENESIS in Angiogenesis: An integrative approach
from science to medicine, Figg, W. and Folkmanl, J. editors, Springer,
Norwell, MA, 2007, in the press.