September 25, 2007

[CURRICULUM VITAE]{.underline}

[Name]{.underline}: Peter Mitchell Blumberg, Ph.D.

[Date and Place of Birth]{.underline}: January 6, l949, Glen Ridge, NJ

[Citizenship]{.underline}: United States

[Marital Status]{.underline}: Married

[Education:]{.underline}

1970 - B.A. Summa Cum Laude, Harvard University, Cambridge, MA

1970 - M.A. (Biochemistry and Molecular Biology), Harvard University,

Cambridge, MA

1974 - Ph.D. (Biochemistry and Molecular Biology), Harvard University,

Cambridge, MA

[Brief Chronology of Employment]{.underline}:

1969-1973 - Graduate student, Department of Biochemistry and Molecular

> Biology, Harvard University, Laboratory of Dr. Jack L.
>
> Strominger, Cambridge, MA
>
> 1974-1975 - Postdoctoral fellow, Department of Biology, Massachusetts
> Institute of Technology, Laboratory of Dr. Phillip W. Robbins,

Cambridge, MA

1975-1981 - Assistant Professor and Associate Professor, Department of

Pharmacology, Harvard Medical School, Cambridge, MA

> 1981-Date - Chief, Molecular Mechanisms of Tumor Promotion Section,
>
> Laboratory of Cancer Biology and Genetics (formerly Laboratory of
> Cellular Carcinogenesis and Tumor Promotion), Center for Cancer
> Research, National Cancer Institute, National Institutes of Health,
> Bethesda, MD

[Societies]{.underline}:

American Association for Cancer Research

American Association for the Advancement of Science

American Chemical Society

American Society for Pharmacology and Experimental Therapeutics

Society for Neuroscience

[Honors and Special Scientific Recognition]{.underline}:

Detur Award given by Harvard for academic excellence, l967

Chemical Industries Council of New Jersey Scholarship, l966-l970

Honorary National Honor Society Scholarship, l966-l970

Honorary Harvard National Scholarship, l966-l970

National Merit Scholarship, l966-l970

Phi Beta Kappa Senior 24, l969

A.B. Summa Cum Laude, l970

Woodrow Wilson Fellow, l970-l97l

National Science Foundation Predoctoral Graduate Fellowship,

Harvard University Honorary Graduate National Scholarship, l970-l973.

Helen Hay Whitney Postdoctoral Fellowship, l973-l975

Medical Foundation Fellowship, Boston, l978-l979

Research Career Development Award, l979-l984

U.S.-Japan Cancer Research Exchange Scholar, University of Tokyo,
October, 1985 Rhoads Memorial Award, American Assoc. Cancer Res., 1987

1989 Ronald R. Fisher Lecturer, University of South Carolina

1989 NIH Merit Award

1991 NIH Directors Award

1995 Public Health Service Superior Service Award

1995, 1997, 1999, 2002, 2003, 2004, 2005, 2006, 2007 Federal Technology
Transfer Act Award

2002 NIH Director's Award for Mentoring

2002 Leading Diversity Award, National Cancer Institute

2005 NIH Director's Award for Mentoring, National Cancer Institute

> 2007 National Public Service Award by the American Society for Public
> Administration and the National Academy of Public Administration

[Research Interests]{.underline}:

> Understanding at the cellular and molecular level the mode of action
> of natural products. Compounds of particular interest are the phorbol
> esters and other structural classes of tumor promoters, as well as the
> resiniferatoxin class of neuromodulators.

[Research Experience]{.underline}:

1981 - Chief, Molecular Mechanisms of Tumor Promotion Section,
Laboratory of Cancer Biology and Genetics (formerly Laboratory of
Cellular Carcinogenesis and Tumor Promotion), Center for Cancer
Research, National Cancer Institute

1975-1981 - Assistant/Associate Professor, Department of Pharmacology,
Harvard Medical School

1974-1975 - Postdoctoral fellow, Department of Biology, Massachusetts
Institute of Technology, in the laboratory of Dr. Phillip W. Robbins;
Cell surfaces and transformation

1969-1975 - Graduate student, Department of Biochemistry and Molecular
Biology, Harvard University, in the laboratory of Dr. Jack L.
Strominger; Bacterial membranes and the mode of action of penicillin;
purification and characterization of the membrane-bound penicillin
binding proteins

[Professional Activities]{.underline}:

Associate Editor, [Cancer Research]{.underline} l98l-1992

Associate Editor, [Journal of the National Cancer
Institute]{.underline}, 1985-present

Regional Editor, [Phytotherapy Research]{.underline}, 1986-1991

Associate Editor, [Cancer Communications]{.underline}, 1988-992

Associate Editor, [Oncology Research]{.underline} (An International
Journal) 1992-present

Editorial Board, [Carcinogenesis]{.underline}, 1989-1991

Program Committee, American Association for Cancer Research, 1981 -1982,

1985-1986, 1990-1991, 1995-1996

Membership Committee, American Association for Cancer Research,
1981-1982

Nominating Committee, American Association for Cancer Research,
1991-1993

Clowes Award Committee, American Association for Cancer Research, 1993

Nominee, Board of Directors, American Association for Cancer Research,
1983

> Biochemistry and Chemical Carcinogenesis Study Section, American
> Cancer Society, 1986-1989; Co-chairman, 1988, Chairman, 1989
>
> Chemical Carcinogenesis and Nutrition Study Section, American Cancer
> Society, [Ad hoc]{.underline} member, 1991

Consultant, Sterling Drug Inc., 1988-1992

National Cancer Assessors Panel, Australia, 1992

Assessors Panel, Anti-Cancer Council of Victoria, Australia, 1995 - 2002

NIH committee on Scientific Conduct and Ethics, 1995 - 2000

PRAT advisory committee, 1997 - present

Advisory Board, Center for Cancer Research, NCI 2007 - present

Present Address: 4723C Reels Mill Road, Frederick, MD 21701

PATENTS

1\. Patent No. 4,939,149, Serial No. 7/261,627, filed 10/24/88 entitled:
\"Use of resiniferatoxin and analogs thereof to cause sensory
afferent-C-fiber and thermoregulatory desensitization\" by P. M.
Blumberg, issued July 3, 1990. Exclusive license for restricted fields
of use to Afferon Corporation.

2\. Patent No. 5,021,450, Serial No. 07/358,073, filed 5/30/89 entitled
\"New class of compounds having a variable spectrum of activities for
capsaicin-like responses, compositions, and uses thereof\" by P. M.
Blumberg, issued June 4, 1991. (European patent application No.
90907806.5, Patent No. 0 474 672, issued August 21,1996). Exclusive
license for restricted fields of use to Afferon Corporation.

3\. Patent No. 5,232,684, Serial No. 07/546,141, filed 5/29/90 entitled
\"Labeled resiniferatoxin, compositions thereof, and methods of using
the same\" by P. M. Blumberg, A. Szallasi, and Z. Szallasi, issued
August 3, 1993. License to Perkin Elmer.

4\. Patent No. 5,599,839, Serial No. 08/424,558 filed 5/30/90 entitled
\"An antiviral composition\" by M. R. Boyd, P. A. Cox, G. M. Cragg, P.
M. Blumberg, N. A. Sharkey, J. Ishitoya, J. B. McMahon, J. A. Beutler,
O. S. Weislow, J. H. Cardellina II, and K. R. Gustafson, issued February
4, 1997. Licensed to AIDS Research Alliance.

5\. Patent No. 5,290,816, Serial No. 07/515,721, filed 6/21/90 entitled
\"Composition of resiniferatoxin and analogues thereof to cause sensory
afferent C-Fiber and Thermoregulatory Desensitization\" by P. M.
Blumberg, issued March 1, 1994. Exclusive license for restricted fields
of use to Afferon Corporation.

6\. Patent No. 5,821,269, Serial No. 07/892,484, filed June 3, 1992
entitled "Treated bird seen preferentially palatable to birds but not
palatable to animals having capsaicin sensitive receptors, by P.M.
Blumberg, issued Oct. 13, 1998. Exclusive license to Snyder Seed
Corporation.

7\. Patent No. 5,672,354, Serial No. 08/596,807, filed Feb. 5, 1996
entitled \"Treated bird seed preferentially palatable to birds but not
palatable to animals having capsaicin sensitive receptors\" by P. M.
Blumberg, issued September 30, 1997. Exclusive license to Snyder Seed
Corporation.

8\. Patent 5,879,696, Serial no. 08/874,082, filed June 12, 1997,
entitled \"Treated bird seed preferentially palatable to birds but not
to animals\", by Peter M. Blumberg, issued March 9, 1999. Exclusive
license to Snyder Seed Corporation.

9\. Patent No. 5,420,162, Serial No. 07/924,439, filed 4/8/91 entitled
\"Phorbol ester pharmaceutical compositions and their use for treating
inflammation\" by P. M. Blumberg and Z. Szallasi, issued May 30, 1995.

10\. Patent No. 5,405,875, Serial No. 08/064,251, filed 5/21/93 entitled
\"Method of inhibiting neoplasia and tumor promotion\" by P. M. Blumberg
and Z. Szallasi, issued April 11, 1995.

11\. Patent No. 5,874,464, Serial No. 08/372,602, filed Jan 13, 1995,
entitled \"Conformationally restricted diacylglycerol analogues as
potent protein kinase C agonists\" by V.E. Marquez, J. Lee, R. Sharma,
S. Wang, G.W.A. Milne, M.C. Nicklaus, P.M. Blumberg, and N.E. Lewin,
issued Feb. 23, 1999.

12\. Patent 5,674,902, serial No. 08/452,392 (Divisional of U.S.S.N.
07/924,439) filed on May 26, 1995 entitled \"Method of inhibiting
hyperplasia to a mammal in need thereof\" by P.M. Blumberg and Z.
Szallasi, issued October 7, 1997.

13\. Patent 6,060,505, Serial 09/142,945, filed on March 20, 1996,
entitled \"Method of treating cancer using 26-epi-bryostatin and
analogues thereof\" by P. M. Blumberg, Z. Szallasi, and G.R. Pettit,
issued May 5, 2000.

14\. International Patent Application No. PCT/US97/21723 (corresponding
to U.S.S. N. 60/030,999, filed on November 15, 1996), entitled
"Vanilloid agonists for desensitization of C-fiber sensory afferent
neurons" by P. M. Blumberg, T. Biro, P. Acs, and G. Acs.

15. European Patent 0546078, application No. 91916656.1, filed on August
    23, 1991, entitled "Birdfood containing capsaicin or its derivatives
    or analogues", by Peter M. Blumberg, issued February 24, 1999.

16. Provisional patent 60/310,656 filed on August 6, 2001, entitled
    "Structurally novel constrained diacylglycerol (DAG) mimetics as
    potent protein kinase C alpha (PKC alpha) activators and potent
    inducers of apoptosis", by J. Lee, V.E. Marquez, P.M. Blumberg, M.G.
    Kazanietz. Commercial evaluation license issued to Peplin under
    license agreement L-218-02/0 May, 2002.

17. Provisional patent 60/395,914, filed July 15, 2002 (PCT/US03/22038,
    filed July 14, 2003) entitled "Protein kinase modulators and methods
    of use thereof", by P.M. Blumberg, H. Hennings, and A.P. Kozikowski.

18. Provisional patent 60/471,210 filed May 16, 2003 entitled "Vanilloid
    receptor antagonists, and methods of making and using them", by A.P.
    Kozikowski, P.M. Blumberg, and A. Toth.

19. Provisional patent 60/558,003, filed March 26, 2004 entitled
    "Vanilloid receptor agonists", by P.M. Blumberg and J. Lee

20\. Provisional patent 60/572,126, filed May 19, 2004, entitled
"Composition of matter and methods of use of fluorescent protein
kinases", by P.M. Blumberg and D. Braun

BIBLIOGRAPHY

1\. Blumberg, P. M.: A mercurial derivative of the Fc fragment of a
human myeloma protein. A.B. thesis, Harvard University, l969.

2\. Steiner, L. A. and Blumberg, P. M.: Mercury derivatives of the Fab
and Fc fragments of a human myeloma protein. [Biochemistry]{.underline}
10: 4727-4739, 1971.

3\. Blumberg, P. M. and Strominger, J. L.: Inactivation of D-alanine
carboxypeptidase by penicillins and cephalosporins is not lethal in
[Bacillus subtilis]{.underline}. [Proc. Natl. Acad. Sci.
USA]{.underline} 68: 28l4-28l7, l97l.

4\. Strominger, J. L., Blumberg, P. M., Suginaka, H., Umbreit, J. and
Wickus, G.: How penicillin kills bacteria - progress and problems.
[Proc. Roy. Soc. Lond]{.underline}. Ser. B l79: 369-383, l97l.

5\. Suginaka, H., Blumberg, P. M. and Strominger, J. L.: Multiple
penicillin binding components in [Bacillus subtilis]{.underline},
[Bacillus cereus]{.underline}, [Staphylococcus aureus]{.underline}, and
[Escherichia coli]{.underline}. [J. Biol. Chem]{.underline}. 247:
5279-5288, l972.

6\. Blumberg, P. M. and Strominger, J. L.: Five penicillin binding
components occur in membranes of [Bacillus subtilis]{.underline}. [J.
Biol. Chem]{.underline}. 247: 8l07-8ll3, l972.

7\. Blumberg, P. M. and Strominger, J. L.: Isolation by covalent
affinity chromatography of the penicillin-binding components from
membranes of [Bacillus subtilis]{.underline}. [Proc. Natl. Acad. Sci.
USA]{.underline} 69: 375l-3755, l972.

8\. Blumberg, P. M. and Strominger, J. L.: Covalent affinity
chromatography as a means of purifying the penicillin binding components
from bacterial membranes. [Methods in Enzymology]{.underline} 34:
40l-405, l974.

9\. Strominger, J. L., Willoughby, E., Kamiryo, T., Blumberg, P. M. and
Yocum, R. R.: Penicillin sensitive enzymes and penicillin binding
components in bacterial cells. [Ann. NY Acad. Sci]{.underline}. 235:
l0-224, l974.

l0. Blumberg, P. M.: Penicillin binding components of bacterial cells
and their relationship to the mechanism of penicillin action. [Ann. NY
Acad. Sci]{.underline}. 235: 3l0-325, l974.

ll. Matsuhashi, S., Kamiryo, T., Blumberg, P. M., Linnett, P.,
Willoughby, E. and Strominger, J. L.: Study of the mechanism of action
and development of resistance to a new amidino penicillin. [J.
Bact]{.underline}. 117: 578-587, l974.

l2. Storm, D. R., Blumberg, P. M. and Strominger, J. L.: Inhibition of
the [Bacillus]{.underline} [subtilis]{.underline} membrane-bound
D-alanine carboxypeptidase by 6-amino- penicillanic acid covalently
coupled to Sepharose. [J. Bact]{.underline}. ll7: 783-785, l974.

l3. Anwar, R., Blumberg, P. M. and Strominger, J. L.: Penicillin binding
components in [Bacillus subtilis]{.underline} during sporulation. [J.
Bact]{.underline}. ll7: 924-925, l974.

l4. Sharpe, A., Blumberg, P. M. and Strominger, J. L.: D-alanine
carboxy- peptidase and cell wall cross-linking in [Bacillus
subtilis]{.underline}. [J. Bact]{.underline}. ll7: 926-927, l974.

l5. Yocum, R. R., Blumberg, P. M. and Strominger, J. L.: Purification
and characterization of the thermophilic D-alanine carboxypeptidase from
membranes of [Bacillus stearothermophilus]{.underline}. [J. Biol.
Chem]{.underline}. 249: 4863-487l, l974.

l6. Blumberg, P. M., Yocum, R. R., Willoughby, E. and Strominger, J. L.:
Binding of ^14^C-penicillin G to the membrane-bound and the purified
D-alanine carboxypeptidases from [Bacillus subtilis]{.underline} and
[Bacillus stearothermophilus]{.underline} and its release. [J. Biol.
Chem]{.underline}. 249: 6829-6835, 1974.

l7. Blumberg, P. M. and Strominger, J. L.: The interaction of penicillin
with the bacterial cell: penicillin binding proteins and penicillin
sensitive enzymes. [Bacteriological Reviews]{.underline} 38: 29l-335,
l974.

l8. Blumberg, P. M.: Penicillin binding components of [Bacillus
subtilis]{.underline}, Ph.D. Thesis, Harvard University, l974.

l9. Robbins, P. W., Wickus, G. G., Branton, P. E., Gaffney, B. J.,
Hirschberg, C. B., Fuchs, P. and Blumberg, P. M.: The chick fibroblast
cell surface following transformation by Rous sarcoma virus. [Cold
Spring Harbor Symposium on Quantitative Biology]{.underline} 39:
ll73-ll80, l975.

20\. Blumberg, P. M. and Robbins, P. W.: Relation of protease action on
the cell surface to growth control and adhesion. In: [Proteases and
Biological Control]{.underline}, Reich, E., Rifkin, D. B., and Shaw, E.,
(Eds.). Cold Spring Harbor Laboratory, pp. 945-956, l975.

2l. Blumberg, P. M. and Robbins, P. W.: Effect of proteases on
activation of resting chick embryo fibroblasts and on cell surface
proteins. [Cell]{.underline} 6: l37-l47.

22\. Blumberg, P. M., Driedger, P. E. and Rossow, P. W.: Effect of a
phorbol ester on a transformation-sensitive surface protein of chick
fibroblasts. [Nature]{.underline} 264: 446-447, l976.

23\. Driedger, P. E. and Blumberg, P. M.: Effects of phorbol diesters on
chick embryo fibroblasts. [Cancer Res]{.underline}. 37: 3257-3265, l977.

24\. Driedger, P. E. and Blumberg, P. M.: Design and construction of a
simple and inexpensive slab gel electrophoresis apparatus. [Anal.
Biochem]{.underline}. 87: 177-l86, l978.

25\. McConnell, M. R. and Blumberg, P. M.: Subunit structure of surface
and shed LETS protein of chick embryo fibroblasts. [Ann. NY Acad.
Sci]{.underline}. 3l2: 4l8-4l9, l978.

26\. McConnell, M. R., Blumberg, P. M. and Rossow, P. W.: Dimeric and
high molecular weight forms of LETS protein on the surface of chick
embryo fibroblasts. [J. Biol. Chem]{.underline}. 253: 7522-7530, l978.

27\. Driedger, P. E. and Blumberg, P. M.: Non-phorbol mouse skin tumor
promoters do not mimic phorbol myristate acetate in its effects on chick
embryo Fibroblasts. [Int. J. Cancer]{.underline} 22: 63-69, l978.

28\. Driedger, P. E. and Blumberg, P. M.: Quantitative correlation
between in vitro and in vivo activities of phorbol esters. [Cancer
Res]{.underline}. 9: 7l4-7l9, l979.

29\. Delclos, K. B. and Blumberg, P. M.: Decrease in collagen production
in normal and Rous sarcoma virus transformed chick embryo fibroblasts
induced by phorbol myristate acetate. [Cancer Res]{.underline}. 39:
l667-l672, l979.

30\. Driedger, P. E. and Blumberg, P. M.: Structure-activity
relationships in chick embryo fibroblasts for phorbol related diterpene
esters showing anomalous activities in vivo. [Cancer Res]{.underline}.
40: 339-346, l980.

3l. Nagle, D. S. and Blumberg, P. M.: Activity of phorbol ester tumor
promoters on enucleated Swiss 3T3 Cells. [Cancer Res]{.underline}. 40:
1066-l072, 1980.

32\. Driedger, P. E. and Blumberg, P. M.: Different biological targets
for resiniferatoxin and phorbol l2-myristate l3-acetate. [Cancer
Res]{.underline}. 40: l400-l404, l980.

33\. Goldberg, A. R., Delclos, K. B. and Blumberg, P. M.: Phorbol ester
action is independent of viral and cellular src kinase levels.
[Science]{.underline} 208: 191-193, l980.

34\. Driedger, P. E. and Blumberg, P. M.: Specific binding of phorbol
ester tumor promoters. [Proc. Natl. Acad. Sci. USA]{.underline} 77:
567-57l, l980.

35\. Delclos, K. B., Nagle, D. S. and Blumberg, P. M.: Specific binding
of phorbol ester tumor promoters to mouse skin. [Cell]{.underline} l9:
l025-l032, l980.

36\. Dunphy, W. G., Lau, C. C. and Blumberg, P. M.: Phorbol related
diterpene esters have similar structure-activity relations in Swiss 3T3
cells and chicken embryo fibroblasts. [Carcinogenesis]{.underline} l:
347-35l, l980.

37\. Dunphy, W. G., Delclos, K. B. and Blumberg, P. M.: Characterization
of specific binding of ^3^H-phorbol l2,l3-dibutyrate and ^3^H-phorbol
l2-myristate l3-acetate to mouse brain. [Cancer Res]{.underline}. 40:
3635-364l, l980.

38\. Blumberg, P. M.: In vitro studies on the mode of action of the
phorbol esters, potent tumor promoters, Part l. [Crit. Rev.
Toxicol]{.underline}. 8: l53-l97, 1980.

39\. Blumberg, P. M.: In vitro studies on the mode of action of the
phorbol esters, potent tumor promoters, Part 2. [Crit. Rev.
Toxicol]{.underline}. 8: l99-234, l98l.

40\. Nagle, D. S., Jaken, S., Castagna, M. and Blumberg, P. M.:
Variation with embryonic development and regional localization of
specific ^3^H- phorbol l2,l3-dibutyrate binding to brain. [Cancer
Res]{.underline}. 4l: 89-93, l98l.

4l. Dunphy, W. G., Kochenburger, R. J., Castagna, M. and Blumberg, P.
M.: Kinetics and subcellular localization of specific ^3^H-phorbol
l2,l3- dibutyrate binding by mouse brain. [Cancer Res]{.underline}. 4l:
2640-2647, 198l.

42\. Jaken, S., Tashjian, Jr, A. H. and Blumberg P. M.: Characterization
of phorbol ester receptors and their down modulation in GH~4~C~1~ rat
pituitary cells. [Cancer Res]{.underline}. 4l: 2l75-2l8l, l98l.

43\. Jaken, S., Tashjian Jr., A. H. and Blumberg P. M.: Relationship
between biological responsiveness to phorbol esters and receptor levels
in GH~4~C~1~ rat pituitary cells. [Cancer Res]{.underline}. 4l:
4956-4960, l98l.

44\. Blumberg, P. M., Butler-Gralla, E. and Herschman, H. R.: Analysis
of phorbol ester receptors in phorbol ester unresponsiveness 3T3 cell
variants. [Biochem. Biophys. Res. Commun]{.underline}. l02: 8l8-823,
l98l.

45\. McConnell, M. R. and Blumberg, P. M.: Transformation of chick
embryo fibroblasts by Rous sarcoma virus does not inhibit the assembly
of fibronectin into reduction-sensitive dimer and high molecular weight
complex. [Cytobios]{.underline} 33: 89-l02, l982.

46\. Blumberg, P. M., Delclos, K. B., Dunphy, W. G. and Jaken, S.:
Specific binding of phorbol ester tumor promoters to mouse tissues and
cultured cells. In: [Cocarcinogenesis and Biological Effects of Tumor
Promoters,]{.underline} Hecker, E., Fusenig, N. E., Kunz, W., Marks, F.,
and Thielmann, H. W. (Eds.) New York, Raven Press, 1982, pp. 5l9-535.

47\. Lew, K. K., Chritton, S. and Blumberg, P. M.: Biological
responsiveness to the phorbol esters and specific binding of
^3^H-phorbol l2,l3-dibutyrate in the nematode Caenorhabditis elegans, a
manipulable genetic system. [Teratog. Carcinog. Mutagen]{.underline}. 2:
l9-30, 1982.

48\. Delclos, K. B. and Blumberg P. M.: Identification of ascorbic acid
as the heat stable factor from brain which inactivates the phorbol ester
receptor. [Cancer Res]{.underline}. 42: l227-l232, l982.

49\. Colburn, N. H., Gindhart, T. D., Hegamyer, G. A., Blumberg, P. M.,
Delclos, K. B., Magun, B. E. and Lockyer, J.: Phorbol diester and
epidermal growth factor receptors in l2-0-tetradecanoylphorbol-13-
acetate-resistant and sensitive mouse epidermal cells. [Cancer
Res]{.underline}. 42: 3093-3097, l982.

50\. Tauber, A. I., Brettler, D. B., Kennington, E. A. and Blumberg, P.
M.: Relation of human neutrophil phorbol ester receptor occupancy and
NADPH-oxidase activity. [Blood]{.underline} 60: 333-339, l982.

5l. Burstein, D. E., Blumberg, P. M. and Greene, L. A.: Nerve
growth-factor induced neuronal differentiation of PCl2 pheochromocytoma
cells: Lack of inhibition by a tumor promoter. [Brain Res]{.underline}.
247: ll5-ll9, l982.

52\. Blumberg, P. M., Delclos, K. B. and Jaken, S.: Tissue and species
specificity for phorbol ester receptors. In: [Organ and Species
Specificity in Chemical Carcinogenesis]{.underline}, Langenbach, R.,
Nesnow, S., and Rice, J. (Eds.), New York, Plenum Press, 1983, pp.
20l-229.

53\. Jaken, S., Shupnik, M. A., Blumberg, P. M. and Tashjian, A. H. Jr.:
Relationship between mezerein-mediated biological responses and phorbol
ester receptor occupancy. [Cancer Res]{.underline}. 43: ll-l4, l983.

54\. Nagle, D. S., and Blumberg, P. M.: Regional localization by light
micro- scopic autoradiography of receptors in mouse brain for phorbol
ester tumor promoters. [Cancer Lett]{.underline}. l8: 35-40, l983.

55\. Blumberg, P. M., Delclos, K. B., Dunn, J. A., Jaken, S., Leach, K.
L. and Yeh, E.: Phorbol ester receptors and the in vitro effects of
tumor promoters. [Proc. NY Acad. of Sci]{.underline}. 407: 303-3l5,
l983.

56\. Delclos, K. B., Yeh, E. and Blumberg, P. M.: Specific labeling of
mouse brain membrane phospholipids with \[20-^3^H\]phorbol
l2-p-azidobenzoate, a photolabile phorbol ester. [Proc. Natl. Acad. Sci.
USA]{.underline} 80: 3054-3058, l983.

57\. Leach, K. L., James, M. L. and Blumberg, P. M.: Characterization of
a specific phorbol ester apo-receptor in mouse brain cytosol. [Proc.
Natl.]{.underline} [Acad. Sci. USA]{.underline} 80: 4208-42l2, l983.

58\. Dunn, J. A. and Blumberg, P. M.: Specific binding of
\[20-^3^H\]l2-deoxy- phorbol l3-isobutyrate to phorbol ester receptor
subclasses in mouse skin particulate preparations. [Cancer
Res]{.underline}. 43: 4632-4637, l983.

59\. Jaken, S., Feldman, H. Blumberg, P. M., and Tashjian, A. H. Jr.:
Association of phorbol ester receptor down modulation with a cryptic
receptor state. [Cancer Res]{.underline}. 43: 5795-5800, l983.

60\. Sharkey, N. A., Leach, K. L. and Blumberg, P. M.: Competitive
inhibition by diacylglycerol of specific phorbol ester binding. [Proc.
Natl. Acad. Sci. USA]{.underline} 8l: 607-6l0, l984.

6l. Blumberg, P. M., Dunn, J. A., Jaken, S., Jeng, A. Y., Leach, K. L.,
Sharkey, N. A. and Yeh, E.: Specific receptors for the phorbol ester
tumor promoters and their involvement in biological responses. In:
[Mechanism of Tumor Promotion, Vol. 3. Tumor Promotion and
Cocarcinogenesis in Vitro]{.underline}, Slaga, T. J. (Ed.). Boca Raton,
CRC Press, 1984, pp. l43-l84.

62\. Blumberg, P. M., Jaken, S., Konig, B., Sharkey, N. A., Leach, K.
L., Jeng, A. Y. and Yeh, E.: Mechanism of action of the phorbol ester
tumor promoters: Specific receptors for lipophilic ligands. [Biochem.
Pharmacol]{.underline}. 33: 933-940, l984.

63\. Blumberg, P. M., Sharkey, N. A., Konig, B., Jaken, S., Leach, K. L.
and Jeng, A. Y.: Membrane and cytosolic receptors for the phorbol ester
tumor promoters. In: [Cancer Cells, Vol l. The Transformed
Phenotype]{.underline}, Levine, A. J., Vande Woude, G. F., Topp, W. C.,
and Watson, J. D. (Eds.). Cold Spring Harbor Laboratory, Cold Spring
Harbor, N.Y., 1984, pp. 245-25l.

64\. Blumberg, P. M., Konig, B., Sharkey, N. A., Leach, K. L., Jaken, S.
and Jeng, A. Y.: Analysis of membrane and cytosolic phorbol ester
receptors. In: [Models, Mechanisms, and Etiology of Tumor
Promotion]{.underline}, Borzsonyi, M., Day, N. E., Lapis, K., and
Yamasaki, H. (Eds.). International Agency for Research on Cancer, Lyon,
France, 1984, pp. l39-l56.

65\. Blumberg, P. M., Sharkey, N. A., Konig, B., Jaken, S., Leach K. L.
and Jeng, A. Y.: Phorbol ester receptors - insights into the initial
events in the mechanism of action of the phorbol esters. In: [Cellular
Interactions by Environmental Tumor Promoters]{.underline}, Fujiki, H.,
Hecker, E., Moore, R. E., Sugimura, T., and Weinstein, I. B. (Eds.).
Tokyo, Japan Sci. Soc. Press, Japan, 1984, pp. 75-87.

66\. Blumberg, P. M., Konig, B., Sharkey, N. A., Jaken, S., Leach, K. L.
and Jeng, A. Y.: Analysis of Phorbol Ester Receptors: A biochemical
approach to understanding the mechanism of action of tumor promoters.
In: [Molecular and Cellular Approaches to Understanding Mechanisms of
Toxicity]{.underline}, Tashjian, A. H. Jr. (Ed.). Harvard School of
Public Health, Boston, MA, pp. l08-l27, l984.

67\. Sharkey, N. A. and Blumberg, P. M.: Highly lipophilic phorbol
esters as inhibitors of specific \[^3^H\]phorbol l2,l3-dibutyrate
binding. [Cancer Res]{.underline}. 45: l9-24, l985.

68\. Konig, B., DiNitto, P. A. and Blumberg, P. M.: Phospholipid and
Ca^++^- dependency of phorbol ester receptors. [J. Cell.
Biochem]{.underline}. 7: 255-265, l985.

69\. Blumberg, P. M., Jeng, A. Y., Konig, B., Sharkey, N. A., Leach, K.
L. and Jaken, S.: Receptors and endogenous analogues for the phorbol
ester tumor promoters. In: [The Role of Chemicals and Radiation in the
Etiology of Cancer]{.underline}, Huberman, E. and Barr, S. H., (Eds.).
New York, Raven Press, 1985, pp. 249-262.

70\. Leach, K. L. and Blumberg, P. M.: Modulation of protein kinase C
activity and \[^3^H\]phorbol l2,l3-dibutyrate binding by various tumor
promoters. [Cancer Res]{.underline}. 45: l958-l963, l985.

71\. Blumberg, P. M., Leach, K. L., Konig, B., Jeng, A. Y. and Sharkey,
N. A.: Receptors for the phorbol ester tumor promoters. In: [Growth
Factors in Biology and Medicine]{.underline}, Evered, D., Nugent, J.,
and Whelan, J. (Eds.). London, Pitman Publishing Ltd., 1985, pp.
205-223.

72\. Konig, B., DiNitto, P. A. and Blumberg, P. M.: Stoichiometric
binding of diacylglycerol to the phorbol ester receptor. [J. Cell.
Biochem]{.underline}. 29: 37-44, l985.

73\. Little, J. B., Nagasawa, H., Weichselbaum, R. R., Lovett, D. R.,
Schmit, A., Kochenburger, R. J. and Blumberg, P. M.: Differing patterns
of cytotoxicity of the phorbol ester l2-0-tetradecanoyl-phorbol
l3-acetate in various human cell strains. [Carcinogenesis]{.underline}
6: 1703-1708, l985.

74\. Dunn, J. A., Jeng, A. Y., Yuspa, S. H. and Blumberg, P. M.:
Heterogeneity of \[^3^H\]phorbol l2,l3-dibutyrate binding in primary
mouse keratinocytes at different stages of maturation. [Cancer
Res]{.underline}. 45: 5540-5546, l985.

75\. Cox, J. A., Jeng, A. Y., Sharkey, N. A., Blumberg, P. M. and
Tauber, A. I.: Activation of the human neutrophil NADPH-oxidase by
protein kinase C. [J. Clin. Invest]{.underline}. 76: 1932-1938, l985.

76\. Jeng, A. Y., Lichti, U., Strickland, J. E. and Blumberg, P. M.:
Similar effects of phospholipase C and phorbol ester tumor promoters on
primary mouse epidermal cells. [Cancer Res]{.underline}. 45: 5714-5721,
1985.

77\. Sharkey, N. A. and Blumberg, P. M.: Kinetic evidence that
1,2-diolein inhibits phorbol ester binding to protein kinase C via a
competitive mechanism. [Biochem. Biophys. Res. Commun]{.underline}. 133:
1051-1056, 1985.

78\. Lichti, U., Strickland, J. E., Jeng, A. Y. and Blumberg, P. M.:
Phospho-lipase C mimics l2-0-tetradecanoylphorbol l3-acetate in the
induction of ornithine decarboxylase and other biochemical changes in
mouse epidermal keratinocytes. In: [Recent Progress in Polyamine
Research]{.underline}, Selmeci, L., Brosnan, M. E., and Seiler, N.
(Eds.). Pergammon Press, Oxford, 1985, pp. 413-422.

79\. Blumberg, P. M., Jeng, A. Y., Konig, B., Sharkey, N. A., Leach, K.
L. and Jaken, S.: Phorbol esters as probes of the regulatory site on
protein kinase C. In: [Natural Products and Biological
Activities]{.underline}, Imura, H., Goto, T., Murachi, T., and Nakajima,
T. (Eds.) New York, Elsevier, 1986, pp. 167-178.

80\. Jeng, A. Y., Sharkey, N. A. and Blumberg, P. M.: Purification of
stable protein kinase C from mouse brain cytosol by specific ligand
elution on fast protein liquid chromatography. [Cancer Res]{.underline}.
46: 1966-1971, 1986.

81\. Sharkey, N. A. and Blumberg, P. M.: Comparison of the activity of
phorbol 12-myristate 13-acetate and the diglyceride glycerol 1-myristate
2-acetate. [Carcinogenesis]{.underline} 7: 677-679, 1986.

82\. Jeng, A. Y., Sharkey, N. A. and Blumberg, P. M.: Purification of
stable protein kinase C from mouse brain cytosol by specific ligand
elution on fast protein liquid chromatography. [FPLC
Biocommunique]{.underline} 3: 6-7, 1986.

83\. Wender, P. A., Koehler, K. F., Sharkey, N. A., Dell\'Aquila, M. L.
and Blumberg, P. M.: Analysis of the phorbol ester pharmacophore on
protein kinase C as a guide to the rational design of new classes of
analogs. [Proc. Natl. Acad. Sci. USA]{.underline} 83: 4214-4218, 1986.

84\. Pasti, G., Lacal, J.-C., Warren, B. S., Aaronson, S. and Blumberg,
P. M.: Loss of Swiss 3T3 response to phorbol ester restored by
microinjected protein kinase C. [Nature]{.underline} 324: 375-377, 1986.

85\. Cox, J. A., Jeng, A. Y., Blumberg, P. M. and Tauber, A. I.:
Comparison of subcellular activation of the human neutrophil
NADPH-oxidase by arachidonic acid, sodium dodecyl sulfate (SDS), and
phorbol myristate acetate (PMA). [J. Immunol]{.underline}. 138:
1884-1888, 1987.

86\. Blumberg, P. M., Nakadate, T., Warren, B. S., Dell\'Aquila, M.,
Sako, T., Pasti, G. and Sharkey, N. A.: Phorbol esters as probes of the
modulatory site on protein kinase C. [Bot. J. Linn. Soc]{.underline}.
94: 283-292, 1987.

87\. Jeng, A. Y., Srivastava, S. K., Lacal, J.C. and Blumberg, P. M.:
Phosphorylation of ras oncogene product by protein kinase C. [Biochem.
Biophys. Res. Commun]{.underline}. 145: 782-788, 1987.

88\. Blumberg, P. M., de Vries, D. J., Dell\'Aquila, M. L., Nakadate,
T., Pasti, G., Sako, T., Sharkey, N. A. and Warren, B. S.: Phorbol ester
tumor promoters as probes of the role of protein kinase C in cellular
regulation. In: [Modern Cell Biology]{.underline}, Waymouth, C. (Ed.)
New York, A. R. Liss, 1987, pp. 79-84.

89\. Nakadate, T., Jeng, A. Y. and Blumberg, P. M.: Effect of
phospholipid on substrate phosphorylation by a catalytic fragment of
protein kinase C. [J. Biol. Chem]{.underline}. 262: 11507-11513, 1987.

90\. Leach, K. L., Frost, M. M., Blumberg, P. M. and Bressler, J. P.:

Second stage tumor promoters: Differences in biological potency and

phorbol ester receptor affinity. [Cancer Lett]{.underline}. 36: 139-147,
1987.

91\. Hennings, H., Blumberg, P. M., Pettit, G. R., Herald, C. L.,
Shores, R.

and Yuspa, S. H.: Bryostatin 1, an activator of protein kinase C,
inhibits tumor promotion by phorbol esters in SENCAR mouse skin.

[Carcinogenesis]{.underline} 8: 1343-1346, 1987.

92\. Sako, T., Yuspa, S. H., Herald, C. L., Pettit, G. R. and Blumberg,
P. M.: Partial parallelism and partial blockade by bryostatin 1 of
effects of phorbol ester tumor promoters on primary mouse epidermal
cells. [Cancer Res]{.underline}. 47: 5445-5450, 1987.

93\. Dell\'Aquila, M. L., Warren, B. S., DeVries, J. D. and Blumberg, P.
M.: Protein kinase C as the site of action of the phorbol ester tumor
promoters. In: [Development and Recognition of the Transformed
Cell]{.underline}, Hamaoka, T. and Greene, M. I. (Eds.). New York,
Plenum Press, 1987, pp. 157-185.

94\. Dell\'Aquila, M. L., Nguyen, H. T., Herald, C. L., Pettit, G. R.
and Blumberg, P. M.: Bryostatin 1 inhibits the phorbol ester-induced
blockage of differentiation in hexamethylene bisacetamide-treated Friend
erythroleukemia cells. [Cancer Res]{.underline}. 47: 6006-6009, 1987.

95\. Lacal, J. C., Fleming, T. P., Warren, B. S., Blumberg, P. M. and
Aaronson, S. A.: Involvement of functional protein kinase C in the
mitogenic response to the H-[ras]{.underline} oncogene product. [Mol.
Cell Biol]{.underline}. 7: 4146-4149, 1987.

96\. Yeh, E., Sharkey, N. A. and Blumberg, P. M.: Influence of side
chains on phorbol ester binding to protein kinase C. [Phytotherapy
Res]{.underline}. 1: 135-139, 1987.

97\. Nakadate, T. and Blumberg, P. M.: Modulation by palmitoylcarnitine
of protein kinase C activation. [Cancer Res]{.underline}. 47: 6537-6542,
1987.

98\. Yuspa, S. H., Hennings, H., Sako, T., Pettit, G. R. Hartley, J. and
Blumberg, P. M.: Tumor promotion: A problem of differential responses of
normal and neoplastic cells to trophic stimuli. In: [Second
International Conference on Anticarcinogenesis and Radiation
Protection]{.underline}, Cerutti, P. A., Nygaard, O. F. and Simic, M. G.
(Eds.), New York, Plenum Press, 1987, pp. 169-174.

99\. Blumberg, P. M.: Protein kinase C as the receptor for the phorbol
ester tumor promoters. Sixth Rhoads Memorial Award Lecture. [Cancer
Res]{.underline}. 48: 1-8, 1988.

100\. Pasti, G., Rivedal, E., Yuspa, S. H., Herald, C. L., Pettit, G. R.
and Blumberg, P. M.: Transient inhibition of cell-cell communication in
primary mouse epidermal cells by bryostatin 1. [Cancer Res]{.underline}.
48: 447-451 1988.

101\. Nakadate, T., Jeng, A. Y. and Blumberg, P. M.: Comparison of
protein kinase C functional assays to clarify mechanisms of inhibitor
action. [Biochem. Pharmacol]{.underline}. 37: 1541-1545, 1988.

102\. Dell\'Aquila, M. L., Herald, C. L., Kamano, Y., Pettit, G. R. and
Blumberg, P. M.: Differential effects of bryostatins and phorbol esters
on arachidonic acid metabolite release and epidermal growth factor
binding in C3H10T1/2 cells. [Cancer Res]{.underline}. 48: 3702-3708,
1988.

103\. Sako, T., Tauber, A. I., Jeng, A. Y., Yuspa, S. H. and Blumberg,
P. M.: Contrasting actions of staurosporine, a protein kinase C
inhibitor, on human neutrophils and primary mouse epidermal cells.
[Cancer Res]{.underline}. 48: 4646-4650, 1988.

104\. Wender, P. A., Cribbs, C. M., Koehler, K. F., Sharkey, N. A.,
Herald, C. L., Kamano, Y., Pettit, G. R. and Blumberg, P. M.: Modeling
of the bryostatins to the phorbol ester pharmacophore on protein kinase
C. [Proc. Nat. Acad. Sci. USA]{.underline}. 85: 7197-7201, 1988.

105\. Warren, B. S., Kamano, Y., Pettit, G. R. and Blumberg, P. M.:
Mimicry of bryostatin 1 induced phosphorylation patterns in HL-60 cells
by high phorbol ester concentrations. [Cancer Res]{.underline}. 48:
5984-5988, 1988.

106\. de Vries, D. J., Herald, C. L., Pettit, G. R. and Blumberg, P. M.:
Demonstration of subnanomolar affinity of bryostatin 1 for the phorbol
ester receptor in rat brain. [Biochem. Pharmacol]{.underline}. 37:
4069-4073, 1988.

107\. de Vries, D. J. and Blumberg, P. M.: Thermoregulatory effects of

resiniferatoxin in the mouse: Comparison with capsaicin. [Life
Sci]{.underline}. 44: 711- 715, 1989.

108\. Tauber, A. I., Cox, J. A., Curnutte, J. T., Carrol, P. M.,
Nakakuma, H., Warren, B., Gilbert, H. and Blumberg, P. M.: Activation of
human neutrophil NADPH-oxidase in vitro by the catalytic fragment of
protein kinase-C. Biochem.Biophys. Res. Commun. 158: 884-890, 1989.

109\. Blumberg, P. M., Pettit, G. R., Warren, B. S., Szallasi, A.,
Schuman, L. D., Sharkey, N. A., Nakakuma, H., Dell\'Aquila, M. L. and de
Vries, D. J.: The protein kinase C pathway in tumor promotion. In: [Skin
Carcinogenesis, Mechanisms and Human Relevance]{.underline}, Slaga,
T.J., Klein- Szanto, A.J.P., Boutwell, R.K., Stevenson, D.E., Spitzer,
H.L., and D\'Motto, B. (Eds.), New York, Alan R. Liss, Inc., 1989, pp.
201-212.

110\. Szallasi, A. and Blumberg, P. M.: Resiniferatoxin, a
phorbol-related diterpene, acts as an ultrapotent analog of capsaicin,
the irritant constituent in red pepper. [Neuroscience]{.underline} 30:
515-520, 1989.

111\. Jeng, A. Y. and Blumberg, P. M.: Biochemical mechanisms of action
of the phorbol ester class of tumor promoters. In: [The Pathobiology
of]{.underline} [Neoplasia,]{.underline} Sirica, A. (Ed.). Plenum Press,
New York, 1989, pp. 371- 383.

112\. Pettit, G. R., Kamano, Y., Schaufelberger, D., Herald, C. L.,
Blumberg, P. M. and May, S. W.: High performance liquid chromatographic
separation of bryostatins 1-12. [J. Liquid Chromatogr]{.underline}. 12:
553-561 (1989).

113\. Leach, K. L. and Blumberg, P. M.: Tumor promoters, their
receptors, and their actions. In: [Inositol Lipids in Cell
Signalling]{.underline}, Michell, R. H., Drummond, A. H., and Downes, C.
P. (Eds.). Academic Press, New York, 1989, pp. 179-205.

114\. Nakakuma, H., Willingham, M. C. and Blumberg, P. M.: Effect of
microinjected catalytic fragment of protein kinase C on morphological
change in Swiss 3T3 cells. [Cancer Comm]{.underline}. 1: 127-132, 1989.

115\. Sharkey, N. A., Hennings, H., Yuspa, S. H. and Blumberg, P. M.:
Comparison of octahydromezerein and mezerein as protein kinase C
activators and as mouse skin tumor promoters.
[Carcinogenesis]{.underline} 10: 1937-1941, 1989.

116\. Szallasi, A. and Blumberg, P. M.: Neurogenic component of phorbol
ester- induced mouse skin inflammation. [Cancer Res]{.underline}. 49:
6052-6057, 1989.

117\. Szallasi, A., Joo, F. and Blumberg, P. M.: Duration of
desensitization and ultrastructural changes in dorsal root ganglia of
rats treated with resiniferatoxin, an ultrapotent capsaicin analog.
[Brain Res]{.underline}. 503: 68- 72, 1989.

118\. Szallasi, A., Sharkey, N. A. and Blumberg, P. M.:
Structure-activity analysis of resiniferatoxin analogs. [Phytotherapy
Res]{.underline}. 6: 253-257, 1989.

119\. Szallasi, A. and Blumberg, P. M.: Effect of resiniferatoxin
pretreatment on the inflammatory response to phorbol 12-myristate
13-acetate in mouse strains with different susceptibilities to phorbol
ester tumor promotion. [Carcinogenesis]{.underline} 11: 583-587, 1990.

120\. Szallasi, A. and Blumberg, P. M.: Specific binding of
resiniferatoxin, an ultrapotent capsaicin analog, by dorsal root
ganglion membranes. [Brain Res]{.underline}. 524: 106-111, 1990.

121\. Szallasi, A. and Blumberg, P.M.: Resiniferatoxin and its analogs
provide novel insights into the pharmacology of the vanilloid
(capsaicin) receptor. [Life Sci]{.underline}. 47: 1399-1408, 1990.

122\. Szolcsanyi, J., Szallasi, A., Szallasi, Z., Joo, F. and Blumberg,
P.M.: Resiniferatoxin, an ultrapotent selective modular of
capsaicin-sensitive primary afferent neurons. [J. Pharmacol. Exp.
Ther]{.underline}. 255: 923-928, 1990.

123\. Szallasi, A., Szallasi, Z. and Blumberg, P.M.: Permanent effects
of neonatally administered resiniferatoxin in the rat. [Brain
Res]{.underline}. 537: 182-186, 1990.

124\. Szallasi, A. and Blumberg, P.M.: Molecular target size of the
vanilloid (capsaicin) receptor in pig dorsal root ganglia. [Life
Sci]{.underline}. 48: 1863-1869, 1991.

125\. Lewin, N. E., Pettit, G. R., Kamano, Y. and Blumberg, P.M.:
Binding of \[26-^3^H\]epi-bryostatin 4 to protein kinase C. [Cancer
Comm]{.underline}. 3: 67-70, 1991.

126\. Szallasi, A. and Blumberg, P.M.: Characterization of vanilloid
receptors in the dorsal horn of pig spinal cord. [Brain
Res]{.underline}. 547: 335-338, 1991.

127\. Pettit, G. R., Sengupta, D., Herald, C. L., Sharkey, N. A. and
Blumberg, P. M.: Synthetic conversion of bryostatin 2 to bryostatin 1
and related bryopyrans. [Can. J. Chem]{.underline}. 69: 856-860, 1991.

128\. Pettit, G. R., Gao, F., Herald, C. L., Blumberg, P. M., Lewin, N.
E. and Nieman, R. A.: Antineoplastic Agents. 224. Isolation and
Structure of Neristatin 1. [J. Am. Chem. Soc]{.underline}. 113:
6693-6695, 1991.

129\. Szallasi, Z. and Blumberg, P. M.: Prostratin, a non-promoting
phorbol ester, inhibits induction by phorbol 12-myristate 13-acetate of
ornithine decarboxylase, edema, and hyperplasia in CD-1 mouse skin.
[Cancer Res]{.underline}. 51: 5355-5360, 1991.

130\. Blumberg, P. M.: Complexities of the protein kinase C pathway.
[Mol.]{.underline} [Carcinog]{.underline}. 4: 339-344, 1991.

131\. Szolcsanyi, J., Szallasi, A., Szallasi, Z., Joo, F. and Blumberg,
P. M.: Resiniferatoxin - An ultrapotent neurotoxin of
capsaicin-sensitive primary afferent neurons. [Ann. N.Y. Acad.
Sci]{.underline}. 632: 473-475, 1991.

132\. Szallasi, A., Szolcsanyi, J., Szallasi, Z., and Blumberg, P. M.:
Inhibition of \[^3^H\]resiniferatoxin binding to rat dorsal root
ganglion membranes as a novel approach in evaluating compounds with
capsaicin-like activity. [Naunyn Schmiedeberg\'s Arch.
Pharmacol]{.underline}. 344: 551-556, 1991.

133\. Hasler, C. M., Acs, G., and Blumberg, P. M.: Specific binding to
protein kinase C by ingenol and its induction of biological responses.
[Cancer Res]{.underline}. 52: 202-208, 1992.

134\. Teng, K., Marquez, V. E., Milne, G. W. A., Barchi, J. J.,
Kazanietz, M. G., Lewin, N. E., Blumberg, P. M., and Abushanab, E.:
Conformationally constrained analogues of diacylglycerol. Interaction of
-lactones with the phorbol ester receptor of protein kinase C. [J. Am.
Chem. Soc]{.underline}. 114: 1059-1070, 1992.

135\. Szallasi, A. and Blumberg, P. M.: Resiniferatoxin. In: Conn, P. M.
(Ed.), [Methods in Neurosciences]{.underline}, Vol. 8, Neurotoxins
Academic Press, Orlando, FL., 1992, pp. 368-380.

136\. Lewin, N. E., Dell\'Aquila, M. L., Pettit, G. R., Blumberg, P. M.
and Warren, B. S.: Binding of \[^3^H\]-Bryostatin 4 to protein kinase C.
[Biochem. Pharmacol]{.underline}. 43: 2007-2014, 1992.

137\. Gustafson, K. R., Cardellina II, J. H., McMahon, J. B.,
Gulakowski, R. T., Ishitoya, J. I., Szallasi, Z., Lewin, N. E.,
Blumberg, P. M., Weislow, O. S., Beutler, J. A., Cox, P. A., Buckheit,
R. W., Cragg, G. M., Bader, J. P. and Boyd, M. R.: A nonpromoting
phorbol from the Samoan medicinal plant [Homalanthus nutans]{.underline}
inhibits cell killing by HIV-1. [J. Med. Chem]{.underline}. 35:
1978-1986, 1992.

138\. Pettit, G. R., Sengupta, D., Blumberg, P. M., Lewin, N. E.,
Schmidt, J. M., and Kraft, A. S.: Structural modifications of bryostatin
2. [Anticancer Drug]{.underline} [Design]{.underline}. 7: 101-113, 1992.

139\. Szallasi, A. and Blumberg, P. M.: Vanilloid receptor loss in rat
sensory ganglia associated with long term desensitization to
resiniferatoxin. [Neuroscience Letters]{.underline} 140: 51-54, 1992.

140\. Blumberg, P. M. and Pettit, G. R.: The bryostatins, a family of
protein kinase C activators with therapeutic potential. In: [New Leads
and Targets in Drug Research]{.underline}, Alfred Benzon Symposium 33,
Krogsgaard-Larsen, P., Christensen, S. B. and Kofod, H. (Eds.),
Copenhagen, Munksgaard International Publishers, pp. 273-285, 1992.

141\. Szallasi, A., Lewin, N. E. and Blumberg, P. M.: Identification of
alpha~1~-acid glycoprotein (orosomucoid) as a major vanilloid-binding
protein in serum. [J. Pharm. Exp. Therap]{.underline}. 262: 883-888,
1992.

142\. Kazanietz, M. G., Krausz, K. and Blumberg, P. M.: Differential
irreversible insertion of protein kinase C into phospholipid vesicles by
phorbol esters and related activators. [J. Biol. Chem.]{.underline} 267:
20878-20886, 1992.

143\. Meini, S., Evangelista, S., Geppetti, P., Szallasi, A., Blumberg,
P. M. and Manzini, S.: Pharmacological and neurochemical evidence for
the activation of capsaicin-sensitive sensory nerves by lipoxin A~4~ in
guinea pig bronchus. [Am. Rev. Respir. Dis]{.underline}. 146: 930-934,
1992.

144\. Szallasi, Z., Krausz, K. and Blumberg, P. M.: Non-promoting
12-deoxyphorbol 13-esters as potent inhibitors of phorbol 12-myristate
13-acetate induced acute and chronic biological responses in CD-1 mouse
skin. [Carcinogenesis]{.underline} 13: 2161-2167, 1992.

145\. Goodnight, J., Kazanietz, M. G., Blumberg, P. M., Mushinski, J. F.
and Mischak, H.: The cDNA sequence, expression pattern and protein
characteristics of mouse protein kinase C-. [Gene]{.underline} 122:
305-311, 1992.

146\. Ozawa, K., Szallasi, Z., Kazanietz, M. G., Blumberg, P. M.,
Mischak, H., Mushinski, J. F. and Beaven, M. A.: Ca^++^-dependent and
Ca^++^-independent isozymes of protein kinase C mediate exocytosis in
antigen-stimulated rat basophilic RBL-2H3 cells: reconstitution of
secretory responses with Ca^++^ and purified isozymes in washed
permeabilized cells. [J. Biol. Chem]{.underline}. 268: 1749-1756, 1993.

147\. Ozawa, K., Yamada, K., Kazanietz, M. G., Blumberg, P. M. and
Beaven, M. A.: Different isozymes of protein kinase C mediate feedback
inhibition of phospholipase C and stimulatory signals for exocytosis in
rat RBL-2H3 cells. [J. Biol. Chem]{.underline}. 268: 2280-2283, 1993.

148\. Szallasi, A. and Blumberg, P. M.: \[^3^H\]resiniferatoxin binding
by the vanilloid receptor: species related differences, effect of
temperature and sulfhydryl reagents. [Naunyn Schmiedeberg\'s Arch.
Pharmacol]{.underline}. 347: 84-91, 1993.

149\. Mischak, H., Goodnight, J., Kolch, W., Martiny-Baron, G.,
Schaechtele, C., Kazanietz, M. G., Blumberg, P. M., Pierce, J. H. and
Mushinski, J. F.: Overexpression of protein kinase C- and - in NIH 3T3
cells induces opposite effects of growth, morphology, anchorage
dependence, and tumorigenicity. [J. Biol. Chem]{.underline}. 268:
6090-6096, 1993.

150\. Szallasi, A. and Blumberg, P. M.: Mechanisms and therapeutic
potential of vanilloids (capsaicin-like molecules). [Adv.
Pharmacol]{.underline}. 24: 123-155, 1993.

151\. Martiny-Baron, G., Kazanietz, M. G., Mischak, H., Blumberg, P. M.,
Kochs, G., Hug, H., Marme, D. and Schaechtele, C.: Selective inhibition
of protein kinase C isozymes by the indolocarbazole Go 6976. [J. Biol.
Chem]{.underline}. 268: 9194-9197, 1993.

152\. Szallasi, Z., Krsmanovic, L. and Blumberg, P. M.: Non-promoting
12-deoxyphorbol 13-esters inhibit phorbol 12-myristate 13-acetate
induced tumor promotion in CD-1 mouse skin. [Cancer Res.]{.underline}
53: 2507-2512, 1993.

153\. Winkler, J. D., Hong, B.-C., Bahador, A., Kazanietz, M. G. and
Blumberg, P. M.: Synthesis of ingenol analogs with affinity for protein
kinase C. [Biorg. Med. Chem. Lett]{.underline}. 3: 577-580, 1993.

154\. Szallasi, A., Conte, B., Goso, C., Blumberg, P. M. and Manzini,
S.: Characterization of a peripheral vanilloid (capsaicin) receptor in
the urinary bladder of the rat. [Life Sci]{.underline}. 52: PL221-226,
1993.

155\. Lee, J., Marquez, V. E., Kazanietz, M. G., Lewin, N. E., Bahador,
A. and Blumberg, P. M.: Conformationally constrained analogs of
diacylglycerol (DAG). 3. Interaction of -alkyl\--lactones with protein
kinase C (PK-C). [Biorg. Med. Chem. Lett]{.underline}. 3: 1101-1106,
1993.

156\. Lee, J., Marquez, V. E., Lewin, N. E., Bahador, A., Kazanietz, M.
G. and Blumberg, P. M.: Conformationally constrained analogs of
diacylglycerol (DAG). 4. Interaction of -alkylidene\--lactones with
protein kinase C (PK-C). [Biorg. Med. Chem. Lett]{.underline}. 3:
1107-1110, 1993.

157\. Szallasi, A., Conte, B., Goso, C., Blumberg, P. M. and Manzini,
S.: Vanilliod receptors in the urinary bladder: regional distribution,
localization on sensory neurons, and species-related differences.
[Naunyn-Schmiedeberg\'s Arch. Pharmacol]{.underline}. 347: 624-629,
1993.

158\. Lee, J., Marquez, V. E., Lewin, N. E. and Blumberg, P. M.:
Synthesis of two rigid diacylglycerol analogs having a perhydro
Furo\[3,4-b\] Furan bis-butyrolactone skeleton. 2.
[Tetrahedron]{.underline} [Lett]{.underline}. 34: 4313-4316, 1993.

159\. Lee, J., Marquez, V. E., Bahador, A., Kazanietz, M. G. and
Blumberg, P. M.: Synthesis of two rigid diacylglycerol analogs having a
perhydro Furo\[3,2-b\] Furan bis-butyrolactone skeleton. 3. [Tetrahedron
Lett]{.underline}. 34: 4317-4320, 1993.

160\. Kazanietz, M. G., Areces, L. B., Bahador, A., Mischak, H.,
Goodnight, J., Mushinski, J. F. and Blumberg, P. M.: Characterization of
ligand and substrate specificity for the calcium-dependent and
calcium-independent PKC isozymes. [Mol. Pharmacol]{.underline}. 44:
298-307, 1993.

161\. Lee, J., Marquez, V. E., Blumberg, P. M., Krausz, K. W. and
Kazanietz, M. G.: Conformationally constrained analogues of
diacylglycerol (DAG). 2. Differential interaction of -lactones and
-lactones with protein kinase C (PK-C). [Biorg. Med. Chem.
Lett]{.underline}. 1: 119-123, 1993.

162\. Szallasi, A., Lewin, N. E. and Blumberg, P. M.: Vanilloid
(capsaicin) receptor in the rat: positive cooperativity of
resiniferatoxin binding and its modulation by reduction and oxidation.
[J. Pharmacol. Exp. Ther]{.underline}. 266: 678-683, 1993.

163\. Mischak, H., Pierce, J. H., Goodnight, J., Kazanietz, M. G.,
Blumberg, P. M. and Mushinski, J. F.: Phorbol ester-induced myeloid
differentiation is mediated by protein kinase C- and - and not by
protein kinase C-II, -, -, and .

> [J. Biol. Chem]{.underline}. 268: 20110-20115, 1993.

164\. Blumberg, P. M., Szallasi, A. and Acs, G.: Resiniferatoxin-an
ultrapotent capsaicin analog. In: [Capsaicin in the study of
pain]{.underline}, Wood, J. N. (Ed), Academic Press, New York, 1993, pp.
45-62.

165\. Sharma, R., Marquez, V.E., Milne, G.W.A., Lewin, N. E. and
Blumberg, P. M.:

> Conformationally constrained analogues of diacylglycerol. 5.
> 2,5-dideoxy-3-0-tetradecanoyl-D-galactonos-1, 4-lactone: a superior
> homologue of 3-0-tetradecanoyl-2-deoxy-L-ribonolactone with PK-C
> binding affinity. [Biorg. Med. Chem. Lett]{.underline}. 3: 1993-1998,
> 1993.

166\. Szallasi, A., Goso, C., Blumberg, P. M. and Manzini, S.:
Competitive inhibition by capsazepine of \[^3^H\]resiniferatoxin binding
to central (spinal cord, dorsal root ganglia) and peripheral (urinary
bladder, airways) vanilloid (capsaicin) receptors in the rat. [J.
Pharmacol. Exp. Ther.]{.underline} 267: 728-733, 1993.

167\. Goso, C., Evangelista, S., Tramontana, M., Manzini, S., Blumberg,
P. M. and Szallasi, A.: Topical capsaicin administration protects
against trinitrobenzene sulfuric acid (TNB)-induced colitis in the rat:
characterization of the vanilloid (capsaicin) receptor involved. [Eur.
J. Pharmacol]{.underline}. 249: 185-190, 1993.

168\. Szallasi, Z., Smith, C. B., Pettit, G. R. and Blumberg, P. M.:
Differential regulation of protein kinase C isozymes by bryostatin 1 and
phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts. [J. Biol.
Chem]{.underline}. 269: 2118-2124, 1994.

169\. Marquez, V. E., Lee, J., Sharma, R., Teng, K., Wang, S., Lewin, N.
E. and Blumberg, P. M.: Conformationally constrained analogues of
diacylglycerol. 6. Changes in PK-C binding affinity for
3-0-Acyl-2-Deoxy-L-ribonolactones bearing different acyl chains. [Biorg.
Med. Chem. Lett]{.underline}. 4: 355-360, 1994.

170\. Lee, J., Marquez, V. E., Lewin, N. E. and Blumberg, P. M.:
Conformationally constrained analogues of DAG. 7. Interaction of a
medium-size -lactone with protein kinase C (PKC). [Bioorg. Med. Chem.
Lett]{.underline}. 4: 543-548, 1994.

171\. Lee, J., Marquez, V. E., Lewin, N. E. and Blumberg, P. M.:
Synthesis of two rigid diacyglycerol analogues having a
1,7-dioxaspiro\[4.4\]nonane bis\--butyrolactone skeleton. 4.
[Synlett.]{.underline} 3:206-208, 1994.

172\. Kazanietz, M. G., Bustelo, X. R., Barbacid, M., Kolch, W.,
Mischak, H., Wong, G., Bruns, J. D. and Blumberg, P. M.: Zinc finger
domains and the phorbol ester pharmacophore: analysis of binding to a
mutated form of PKC zeta, and the vav and c-raf protooncogene products.
[J. Biol. Chem]{.underline}. 269:11590-11594, 1994.

173\. Acs, G., Palkovits, M. and Blumberg, P. M.:
\[^3^H\]resiniferatoxin binding by the human vanilloid (capsaicin)
receptor. [Mol. Brain Res]{.underline}. 23: 185-190, 1994.

174\. Kozikowski, A. P., Ma, D., Du, L., Lewin, N. E. and Blumberg, P.
M.: Synthesis of the benzofuran analogue of ILV, a new protein kinase C
(PKC) activator. [Bioorg. Med. Chem. Lett]{.underline}. 4:637-640, 1994.

175\. Acs, G. and Blumberg, P. M.: Comparison of \[^3^H\]resiniferatoxin
binding to spinal cord and dorsal root ganglia of newborn and adult
rats. [Life Sci]{.underline}. 54: 1875-1882, 1994.

176\. Wang, S., Milne, G. W. A., Nicklaus, M. C., Marquez, V. E., Lee,
J. and Blumberg, P. M.: Protein kinase C. Modeling of the binding site
and prediction of binding constants. [J. Med. Chem.]{.underline} 37:
1326-1338, 1994.

177\. Blumberg, P. M., Acs, G., Areces, L. B., Kazanietz, M. G., Lewin,
N. E. and Szallasi, Z.: Protein kinase C in signal transduction and
carcinogenesis. In: Spizer, H.L., Slaga, T. J., Greenlee, W.F. and
McClain, M. (Eds), Receptor-mediated Biological Processes: Implications
for Evaluating Carcinogens. [Wiley Liss]{.underline}, N.Y., pp. 3-19.

178\. Acs, G. and Blumberg, P. M.: \[^3^H\]resiniferatoxin binding to
pig dorsal horn membrane displays positive cooperativity. [Life
Sci]{.underline}. 55: 337-346, 1994.

179\. Seynaeve, C. M., Kazanietz, M. G., Blumberg, P. M., Sausville, E.
A. and Worland, P. J.: Differential inhibition of protein kinase C
isozymes by UCN-01, a staurosporine analogue. [Mol.
Pharmacol]{.underline}. 45: 1207-1214, 1994.

180\. Areces, L.B., Kazanietz, M.G. and Blumberg, P.M.: Close similarity
of baculovirus expressed n-chimaerin and protein kinase C as phorbol
ester receptors. [J. Biol. Chem.]{.underline} 269: 19553-19558, 1994.

181\. Razin, E., Szallasi, Z., Kazanietz, M. G., Blumberg, P. M. and
Rivera, J.: Protein Kinase C- and link the mast cell high affinity
receptor for IgE to the expression of C-fos and c-jun. [Proc. Natl.
Acad. Sci. USA]{.underline}. 91: 7722-7726, 1994.

182\. Acs, G., Palkovits, M. and Blumberg, P.M. Comparison of
\[^3^H\]resiniferatoxin binding by the vanilloid (capsaicin) receptor in
dorsal root ganglia, spinal cord, dorsal vagal complex, sciatic and
vagal nerve and urinary bladder of the rat. [Life Sci]{.underline} 55:
1017-1026, 1994.

183\. Kazanietz, M. G., Lewin, N. E., Gao, F., Pettit, G. R. and
Blumberg, P. M.: Binding of \[26-^3^H\]bryostatin 1 and analogs to
calcium-dependent and calcium-independent PKC isozymes. [Mol.
Pharmacol]{.underline}. 46: 374-379, 1994.

184\. Lee, J., Sharma, R., Teng, K., Lewin, N.E., Blumberg, P.M. and
Marquez, V.E.: Conformationally constrained analogues of DAG. 8. Changes
in PK-C binding affinity produced by isosteric groups of the 3-O-acyl
function in 2-deoxy-L-ribonolactones. [Bioorg. Med. Chem.
Lett.]{.underline} 4: 1369-1374, 1994.

185\. Germano, P., Gomez, J., Kazanietz, M.G., Blumberg, P.M. and
Rivera, J.: Phosphorylation of the chain of the high affinity receptor
for immunoglobulin E by receptor-associated protein kinase C-. [J. Biol.
Chem.]{.underline} 269: 23102-23107, 1994.

186\. Szallasi, Z., Smith, C.B. and Blumberg, P.M.: Dissociation of
phorbol esters leads to immediate redistribution to the cytosol of
protein kinase C and in mouse keratinocytes. [J. Biol.
Chem.]{.underline} 269: 27159-27162, 1994.

187\. Lee, J., Lewin, N.E., Blumberg, P.M. and Marquez, V.E.:
Conformationally constrained analogues of diacylglycerol. 9. The effect
of side-chain orientation on the protein kinase C (PK-C) binding
affinity of -lactones. [Bioorg. Med. Chem. Lett.]{.underline}
4:2405-2410, 1994.

188\. Szallasi, Z., Denning, M. F., Smith, C. B., Dlugosz, A. A., Yuspa,
S. H., Pettit, G. R. and Blumberg, P. M.: Bryostatin 1 protects PKC
delta from down-regulation in mouse keratinocytes in parallel with its
inhibition of phorbol ester induced differentiation. [Mol.
Pharmacol.]{.underline} 46:840-850, 1994.

189\. Szallasi, A., Blumberg, P.M., Nilsson, S., Hökfelt, T., and
Lundberg, J.M. Visualization by \[^3^H\]resiniferatoxin autoradiography
of capsaicin-sensitive neurons in the rat, pig, and man. [Eur. J.
Pharmacol.]{.underline} 264: 217-221, 1994.

190\. Wang, S., Zaharevitz, D.W., Sharma, R., Marquez, V.E., Lewin,
N.E., Du, L., Blumberg, P.M., and Milne, G.W.A. The discovery of novel,
structurally diverse PK-C agonists through 3D-database pharmacophore
search. Molecular modeling studies. [J. Med. Chem]{.underline}. 37:
4479-4489, 1994.

191\. Denning, M.F., Dlugosz, A.A., Williams, E.K., Szallasi, Z.,
Blumberg, P.M. and Yuspa, S.H. Specific protein kinase C isozymes
mediate the induction of keratinocyte differentiation markers by
calcium. [Cell Growth and Differentiation]{.underline} 6:149-157, 1995.

192\. Szallasi, Z., Kosa, K., Smith, C.B., Dlugosz, A.A., Williams,
E.K., Yuspa, S.H. and Blumberg, P.M. Differential regulation by the
anti-promoting 12-deoxyphorbol 13-phenylacetate reveals distinct roles
of the classical and novel protein kinase C isozymes in biological
responses of primary mouse keratinocytes. [Mol. Pharmacol.]{.underline}
47: 258-265, 1995.

193\. Winkler, J.D., Hong, B.-C., Bahador, A., Kazanietz, M.G. and
Blumberg, P.M. Methodology for the synthesis of 3-oxygenated ingenanes
\-- the first ingenol analogs with high affinity for protein kinase C.
[J. Org. Chem.]{.underline} 60:1381-1390, 1995.

194\. Szallasi, A., Blumberg, P.M. and Lundberg, J.M. Proton inhibition
of \[^3^H\]resiniferatoxin binding to vanilloid (capsaicin) receptors in
rat spinal cord. [Eur. J. Pharmacol.]{.underline} 289: 181-187, 1995.

195\. Kazanietz, M.G., Lewin, N.E., Bruns, J.D. and Blumberg, P.M.
Characterization of the cysteine-rich region of the Caenorhabditis
elegans protein unc-13 as a high affinity phorbol ester receptor:
analysis of ligand-binding interactions, lipid cofactor requirements,
and inhibitor-sensitivity. [J. Biol. Chem]{.underline}. 270:
10777-10783, 1995.

196\. Lee, J., Acs, G., Blumberg, P.M. and Marquez, V.E. Thiourea
analogues of resiniferatoxin as ligands for the vanilloid receptor.
[Bioorg. Med. Chem. Lett.]{.underline} 5: 1331-1334, 1995.

197\. Kazanietz, M.G., Barchi, J.J. Jr., Omichinski, J.G. and Blumberg,
P.M. Low affinity binding of phorbol esters to protein kinase C and its
recombinant cysteine-rich region in the absence of phospholipids. [J.
Biol. Chem.]{.underline} 270: 14679-14684, 1995.

198\. Zhang, G., Kazanietz, M.G., Blumberg, P.M. and Hurley, J.H.
Crystal structure of the cys2 activator-binding domain of protein kinase
C in complex with phorbol ester. [Cell]{.underline} 81:917-924, 1995.

199\. Blumberg, P.M., Acs, G., Acs, P., Areces, L.B., Kazanietz, M.G.,
Lewin, N.E. and Szallasi, Z. Protein kinase C in cell signaling:
strategies for the development of selective inhibitors. N. S. Doherty
(Ed.), [Inflammation: mechanisms and therapeutics]{.underline}.
Birkhauser Verlag, Basel, 1995, pp. 87-100.

200\. Acs, G., Lee, J., Marquez, V.E., Wang, S., Milne, G.W.A., Du, L.,
Lewin, N.E. and Blumberg, P.M. Resiniferatoxin-amide and analogs as
ligands for protein kinase C and vanilloid receptors and determination
of their biological activities as vanilloids. [J.
Neurochem.]{.underline} 65: 301-398, 1995.

201\. Kozikowski, A.P., Ma, D.W., Du, L., Lewin, N.E. and Blumberg, P.M.
Effect of alteration of the heterocyclic nucleus of ILV on its isoform
selectivity for PKC. Palladium catalyzed route to benzofuran analogs of
ILV. [J. Am. Chem. Soc.]{.underline} 117: 6666-6672, 1995.

202\. Lehel, C., Olah, Z., Jakab, G., Szallasi, Z., Petrovics, G.,
Blumberg, P.M. and Anderson, W.B. Protein kinase C subcellular
localization domains and proteolytic degradation sites. A model for
protein kinase C conformational changes. [J. Biol. Chem.]{.underline}
270: 19651-19658, 1995.

203\. Winkler, J.D., Hong, B.-C., Kim, S., Lewin, N.E. and Blumberg,
P.M. On the protein kinase C pharmacophore: synthesis and biological
activity of 4-hydroxylated analogs of ingenol. [Synlett]{.underline} ,
533-535, 1995.

204\. Kazanietz, M.G., Wang, S., Milne, G.W.A., Lewin, N.E., Liu, H.L.,
and Blumberg, P.M. Residues in the second cysteine-rich region of PKC
relevant to phorbol ester binding as revealed by site-directed
mutagenesis. [J. Biol. Chem.]{.underline} 270:21852-21859, 1995.

205\. Szallasi, Z., Denning, M.F., Chang, E.-Y., Rivera, J., Yuspa,
S.H., Lehel, C., Olah, Z., Anderson, W.B., and Blumberg, P.M.
Development of a rapid approach to identification of tyrosine
phosphorylation sites: application to PKC phosphorylated upon activation
of the high affinity receptor for IgE in rat basophilic leukemia cells.
[Biochem. Biophys. Res. Comm.]{.underline} 214: 888-894, 1995.

206\. Smith, H., Chang, E.-Y., Szallasi, Z., Blumberg, P.M., and Rivera,
J. Tyrosine phosphorylation of protein kinase C- in response to the
activation of the high affinity receptor for immunoglobulin E modifies
its substrate recognition. [Proc. Natl. Acad. Sci. U.S.A.]{.underline}
92: 9112-9116, 1995.

207\. Acs, G., Palkovits, M. and Blumberg, P.M. Trifluoperazine
modulates \[^3^H\]resiniferatoxin binding by human and rat vanilloid
(capsaicin) receptors and affects ^45^Ca uptake by adult rat dorsal root
ganglion neurones. [J. Pharmacol. Exp. Therap.]{.underline} 274:
1090-1098, 1995.

208\. Acs, P., Szallasi, Z., Kazanietz, M.G. and Blumberg, P.M.
Differential activation of PKC isozymes by 14-3-3 protein. [Biochem.
Biophys. Res. Commun.]{.underline} 216: 103-109, 1995.

209\. Scala, S., Dickstein, B., Szallasi, Z., Blumberg, P.M. and Bates,
S.E. Bryostatin 1 affects P-glycoprotein phosphorylation but not
function in multidrug resistant human breast cancer cells. [Clinical
Cancer Res,]{.underline} 1: 1581-1587, 1995.

210\. Kazanietz, M.G. and Blumberg, P.M. Protein kinase C and signal
transduction in normal and neoplastic cells. In [Cellular and Molecular
Pathogenesis]{.underline}, A.E. Sirica, ed., Raven Press, N.Y., 1996,
pp. 389-402.

211\. Szallasi, A., Nilsson, S., Farkas-Szallasi, T., Hökflet, T,
Blumberg, P.M., and Lundberg, J.M. Vanilloid (capsaicin) receptors in
the rat: distribution in the brain, regional differences in the spinal
cord, axonal transport to the periphery, and depletion by systemic
vanilloid treatment. [Brain Res.]{.underline} 703:175-183, 1995.

212\. Acs, G., Lee, J., Marquez, V.E. and Blumberg, P.M. Distinct
structure-activity relations for stimulation of ^45^Ca uptake and for
high affinity binding by cultured rat dorsal root ganglion neurons and
dorsal root ganglion membranes. [Mol. Brain Res.]{.underline} 35:
173-182, 1996.

213\. Sharma, R., Lee, J., Wang, S., Milne, G.W.A., Lewin, N.E.,
Blumberg, P.M. and Marquez, V.E. Conformationally constrained analogues
of diacylglycerol. 10. Ultrapotent protein kinase C (PK-C) ligands based
on a racemic 5-disubstituted tetrahydro-2-furanone template. [J. Med
Chem.]{.underline} 39: 19-28, 1996.

214\. Lee, J., Wang, S., Milne, G.W.A., Sharma, R., Lewin, N.E.,
Blumberg, P.M. and Marquez, V.E. Conformationally constrained analogues
of diacylglycerol. 11. Ultrapotent protein kinase C (PK-C) ligands based
on a chiral 5-disubstituted tetrahydro-2-furanone template. [J. Med.
Chem.]{.underline} 39: 29-35, 1996.

215\. Lee, J., Sharma, R., Wang, S., Milne, G.W.A., Lewin, N.E.,
Szallasi, Z., Blumberg, P.M., George, C. and Marquez, V.E.
Conformationally constrained analogues of diacylglycerol. 12.
Ultrapotent protein kinase C (PK-C) ligands based on a chiral
4-disubstituted heptono-1,4-lactone template. [J. Med.
Chem.]{.underline} 39: 36-45, 1996.

216\. Denning, M.F., Kazanietz, M.G., Blumberg, P.M. and Yuspa, S.H.
Cholesterol sulfate activates multiple protein kinase C isoenzymes and
induces granular cell differentiation in cultured murine keratinocytes.
[Cell Growth Diff.]{.underline} 6: 1619-1626, 1995.

217\. Szallasi, A., Nilsson, S., Blumberg, P.M., Hökfelt, T. and
Lundberg, J.M. Binding of neuroleptic drugs (trifluoperazine and
rimcazole) to vanilloid receptors in porcine dorsal horn. [Eur. J.
Pharmacol.]{.underline} 298: 321-327, 1996.

218\. Szallasi, A., Acs, G., Cravotto, G., Blumberg, P.M. and Appendino,
G. A novel agonist, phorbol 12-phenylacetate 13-acetate
20-homovanillate, abolishes positive cooperativity of binding by the
vanilloid (capsaicin) receptor. [Eur. J. Pharmacol.]{.underline} 299:
221-228, 1996.

219\. Kazanietz, M.G., and Blumberg, P.M. The phorbol ester binding site
in protein kinase C: a comprehensive biochemical and structural analysis
using the GST-expression system. [Science Tools]{.underline} 1: 3-5,
1996.

220\. Szallasi, Z., Du, L., Levine, R., Lewin, N.E., Nguyen, P.N.,
Williams, M.D., Pettit, G.R. and Blumberg, P.M. The bryostatins inhibit
growth of B16/F10 melanoma cells in vitro through a protein kinase
C-independent mechanism: dissociation of activities using
26-epi-bryostatin 1. [Cancer Res.]{.underline} 56: 2105-2111, 1996.

221\. Pettit, G.R., Gao, F., Blumberg, P.M., Herald, C.L., Coll, J.C.,
Kamano, Y., Lewin, N.E., Schmidt, J.M. and Chapuis, J.-C. Antineoplastic
agents 340. Isolation and structural elucidation of bryostatins 16-18.
[J. Nat. Prod.]{.underline} 59: 286-289, 1996.

222\. Wang, S., Kazanietz, M.G., Blumberg, P.M., Marquez, V.E. and
Milne, G.W.A. Molecular modeling and site-directed mutagenesis studies
of the phorbol ester binding site in protein kinase C. [J. Med.
Chem.]{.underline} 39: 2541-2553, 1996.

223\. Szallasi, Z., Bogi, K., Gohari, S., Biro, T., Acs, P. and
Blumberg, P.M. Non-equivalent roles for the first and second
zinc-fingers of protein kinase C: effect of their mutation on phorbol
ester induced translocation in NIH 3T3 cells. [J. Biol.
Chem.]{.underline} 271: 18299-18301, 1996

224\. Farkas-Szallasi, T., Bennett, G.J., Blumberg, P.M., Hökfelt, T.,
Lundberg, J.M. and Szallasi, A. Vanilloid receptor loss is independent
of the messenger plasticity that follows systemic resiniferatoxin
administration. [Brain Res.]{.underline} 719: 213-218, 1996.

225\. Jideama, N.M., Noland, T.A., Jr., Raynor, R.L., Blobe, G.C.,
Fabbro, D., Kazanietz, M.G., Blumberg, P.M., Hannun, Y.A. and Kuo,
J.F.Phosphorylation specificities of protein kinase C isozymes for
bovine cardiac troponin 1 and troponin T and sites within these proteins
and regulation of myofilament properties. [J. Biol. Chem.]{.underline}
271:23277-23283, 1996.

226\. Szallasi, A., Jonassohn, M., Acs, G., Biro, T., Acs, P., Blumberg,
P.M. and Sterner, O. The stimulation of capsaicin-sensitive neurons in a
vanilloid receptor mediated fashion by pungent terpenoids possessing an
unsaturated 1,4-dialdehyde moiety. [Br. J. Pharmacol]{.underline}. 119:
283-290, 1996.

227\. Acs, G., Palkovits, M. and Blumberg, P.M. Specific binding of
\[^3^H\]resiniferatoxin by human and rat preoptic area, locus ceruleus,
medial hypothalamus, reticular formation, and ventral thalamus membrane
preparations. [Life Sci.]{.underline} 59: 1899-1908, 1996.

228\. Lee, J., Lewin, N.E., Blumberg, P.M. and Marquez, V.E. Synthesis
of Bis\--butyrolactones containing conformationally constrained (S)- and
(R)-diacylglycerol structures. [Bioorg. Med, Chem.]{.underline} 4:
1299-1305, 1996.

229\. Lee, J., Lewin, N.E., Acs, P., Blumberg, P.M. and Marquez, V.E.
Conformationally constrained analogues of diacylglycerol. 13. Protein
kinase C ligands based on templates derived from
2,3-dideoxy-L-erthryo(threo)-hexono-1,4-lactone and 2-deoxyapiolactone.
[J. Med. Chem]{.underline}. 39: 4912-4919, 1996.

230\. Noland, T.A., Jr., Raynor, R.L., Jideama, N.M., Guo, Z.,
Kazanietz, M.G., Blumberg, P.M., Solaro, R.J. and Kuo, J.F. Differential
regulation of cardiac actomyosin S-1 MgATPase by protein kinase C
isozyme-specific phosphorylation of specfic sites in cardiac troponin 1
and its phosphorylation site mutants. [Biochemistry]{.underline} 35:
14923-14931, 1996.

231\. Wang, Q.J., Acs, P., Goodnight, J., Giese, T., Blumberg, P.M.,
Mischak, H. and Mushinski, J.F. The catalytic domains of protein kinase
C- in reciprocal and chimeras mediates phorbol ester-induced macrophage
differentiation of mouse promyelocytes. [J. Biol. Chem]{.underline}.
272: 76-82, 1997.

232\. Szallasi, A. and Blumberg, P.M. Vanilloid receptors: new insights
enhance potential as a therapeutic target, [Pain]{.underline} 68:
195-208, 1996.

233\. Hurley, J.H., Newton, A.C., Parker, P.J., Blumberg, P.M. and
Nishizuka, Y. Taxonomy and function of C1 protein kinase C homology
domains. [Protein Science]{.underline} 6: 477-480, 1997.

234\. Kozikowski, A.P., Wang, S., Ma, D., Yao, J., Ahmad, S., Glazer,
R.I., Bogi, K., Acs, P., Modarres, S., Lewin, N.E. and Blumberg, P.M.
Modeling, chemistry, and biology of the benzolactam analogues of ILV.2.
Identification of the binding site of the benzolactams in the CRD2
activator-binding domain of PKC and discovery of an ILV analogue of
improved isozyme selectivity. [J. Med. Chem.]{.underline} 40: 1316-1326,
1997.

235\. Rosson, D., O'Brien, T.G., Kampherstein, J.A., Szallasi, Z., Bogi,
K., Blumberg, P.M. and Mullin, J.A. PKC activity modulates
transepithelial permeability and cell junctions in the LLC-PK~1~
epithelial cell line. [J. Biol. Chem.]{.underline} 272: 14950-14953
(1997).

236\. Acs, G., Biro, T., Acs, P., Modarres, S. and Blumberg, P.M.
Differential activation and desensitization of sensory neurons by
resiniferatoxin. [J. Neuroscience]{.underline} 17: 5622-5628, 1997.

237\. Biro, T., Acs, G., Acs, P., Modarres, S. and Blumberg, P.M. Recent
advances in understanding of vanilloid receptors: a therapeutic target
for treatment of pain and inflammation in skin. [J. Invest. Dermatol.
Symp. Proc.]{.underline} 2: 56-60, 1997.

238\. Acs, P., Bogi, K., Lorenzo, P., Marquez, A., Biro, T., Szallasi,
Z. and Blumberg, P.M. The catalytic domain of protein kinase C chimeras
modulates the affinity and targeting of phorbol ester-induced
translocation. [J. Biol. Chem.]{.underline} 272: 22148-22153, 1997.

239\. Chang, E.-Y., Szallasi, Z., Acs, P., Raizada, V., Wolfe, P.C.,
Fewtrell, C., Blumberg, P.M. and Rivera, J. Functional effects of
overexpression of the protein kinase C isozymes , , , , and in the mast
cell line RBL-2H3. [J. Immunol.]{.underline} 159: 2624-2632, 1997.

240\. Caloca, M.J., Fernandez, M.N., Lewin, N.E., Ching, D., Modali, R.,
Blumberg, P.M. and Kazanietz, M.G. 2-chimaerin is a high affinity
receptor for the phorbol ester tumor promoters. Analysis of phorbol
ester binding and subcellular distribution after phorbol ester
treatment. [J. Biol. Chem.]{.underline} 272:26488-26496, 1997.

241\. Acs, P., Wang, Q.J., Bogi, K., Marquez, A.M., Lorenzo, P.S., Biro,
T., Szallasi, Z., Mushinski, J.F. and Blumberg, P.M. Both the catalytic
and the regulatory domains of protein kinase C chimeras modulate the
proliferation properties of NIH 3T3 cells [J. Biol. Chem.]{.underline}
272: 28793-28799, 1997.

242\. Lee, J., Kim, S.H., Chun, M.W., Blumberg, P.M., Lewin, N.E. and
Marquez, V.E. Conformationally constrained analogues of diacylglycerol:
protein kinase C (PK-C) ligands based on a 5-disubstituted
tetrahydro-2-furanone template having an (R)-hydroxyethyl group.
[Carbohydrate Letters]{.underline} 2: 307-312, 1997.

243\. Lorenzo, P.S., Bogi, K., Acs, P., Pettit, G.R. and Blumberg, P.M.
The catalytic domain of PKC confers protection from down regulation
induced by bryostatin 1. [J. Biol. Chem.]{.underline} 272: 33338-33343,
1997.

244\. Appel, E., Kolman, O., Kazimirsky, G., Blumberg, P.M. and Brodie,
C. Regulation of GDNF expression in cultured astrocytes by inflammatory
stimuli. [Neuroreport]{.underline} 8: 3309-3312, 1997.

245\. Wang, Q.J., Acs, P., Goodnight, J., Blumberg, P.M., Mischak, H.
and Mushinski, J.F. The catalytic domain of PKC-, in reciprocal PKC-
and - chimeras, is responsible for conferring tumorigenicity upon NIH
3T3 cells, while both regulatory and catalytic domains of PKC-
contribute to in vitro transformation. [Oncogene]{.underline} 16: 53-60,
1998.

246\. Biro, T., Maurer, M., Modarres, S., Lewin, N.E., Brodie, C., Acs,
G., Acs, P., Paus, R. and Blumberg, P.M. Characterization of functional
vanilloid receptors expressed by mast cells. [Blood]{.underline} 91:
1332-1340, 1998.

247\. Gubina, E., Rinaudo, M.S., Szallasi, Z., Blumberg, P.M. and
Mufson, R.A. Overexpression of protein kinase C isoform but not in human
interleukin-3- dependent cells suppresses apoptosis and induces Bcl-2
expression. [Blood]{.underline} 91: 823-829, 1998.

248\. Bogi, K., Lorenzo, P.S., Szallasi, Z., Acs, P., Wagner, G.S. and
Blumberg, P.M. Differential selectivity of ligands for the C1a and C1b
phorbol ester binding domains of protein kinase C delta: possible
correlation with tumor promoting activity. [Cancer Res]{.underline}. 58:
1423-1428, 1998.

249\. Lee, J., Lewin, N.E., Blumberg, P.M. and Marquez, V.E.
Conformationally constrained analogues of diacylglycerol having a
perhydrofuro\[3,4-c\]furan-1,4-dione bis\--butyrolactone skeleton.
[Arch. Pharm. Res.]{.underline} 21: 164-167, 1998.

250\. Brodie, C., Blumberg, P.M. and Jacobson, K.A. Activation of the
A~2A~ adenosine receptor inhibits nitric oxide production in glial
cells. [FEBS Letters]{.underline} 429: 139-142, 1998.

251\. Qiao, L., Wang, S., George, C., Lewin, N.E., Blumberg, P.M. and
Kozikowski, A.P. Structure-based design of a new class of protein kinase
C modulators. [J. Am. Chem. Soc.]{.underline} 120: 6629-6630, 1998.

252 Marquez, V.E., Sharma, R., Wang, S., Lewin, N.E., Blumberg, P.M.,
Kim, I.S. and Lee, J. Conformationally constrained analogues of
diacylglycerol (DAG). 14. Dissection of the roles of the sn-1 and sn-2
carbonyls in DAG mimetics by isopharmacophore replacement. [Bioorg. Med.
Chem. Letters]{.underline} 8: 1757-1762, 1998.

253\. Song, J.S., Swann, P.G., Szallasi, Z., Blank, U., Blumberg, P.M.
and Rivera, J. Tyrosine phosphorylation-dependent and -independent
associations of protein kinase C- with Src family kinases in the RBL-2H3
mast cell line: cross-talk in the regulation of Src family kinase
activity. [Oncogene]{.underline} 16: 3357-3368, 1998.

254\. Biro, T., Brodie, C., Modarres, S., Lewin, N.E., Acs, P. and
Blumberg, P.M. Specific vanilloid responses in C6 rat glioma cells.
[Mol. Brain Res.]{.underline} 56: 89-98, 1998.

255\. Brodie, C., Kuperstein, I., Acs, P. and Blumberg, P.M.
Differential role of specific PKC isoforms in the proliferation of glial
cells and the expression of the astrocytic markers GFAP and glutamine
synthetase. [Mol. Brain Res.]{.underline} 56: 108-117, 1998.

256\. Szallasi, A., Biro, T., Modarres, S., Garlaschelli, L., Petersen,
M., Klusch, A., Vidari, G., Jonassohn, M., De Rosa, S., Sterner, O.,
Blumberg, P.M. and Krause, J.E. Dialdehyde sesquiterpenes and other
terpenoids as vanilloids. [Europ. J. Pharmacol.]{.underline} 356: 81-89,
1998.

257\. Brodie, C., Bogi, K., Acs, P., Lorenzo, P.S., Baskin, L. and
Blumberg, P.M. The inhibitory effect of PKC on glutamine synthetase
expression in glial cells is mediated by the regulatory domain of PKC
and its tyrosine phosphorylation. [J. Biol. Chem.]{.underline} 273:
30713-30718, 1998.

258\. Benzaria, S., Bienfait, B., Nacro, K., Wang, S., Lewin, N.E.,
Beheshti, M., Blumberg, P.M. and Marquez, V.E. Conformationally
constrained analogues of diacylglycerol (DAG). 15. The indispensable
role of the *sn*-1 and *sn*-2 carbonyls in the binding of DAG-lactones
to protein kinase C (PK-C). [Bioorg. Med. Chem. Lett.]{.underline} 8:
3403-3408, 1998.

259\. Brodie, C., Bogi, K., Acs, P., Lazarovici, P., Petrovics, G.,
Anderson, W.B. and Blumberg, P.M. Protein kinase C- plays a role in
neurite outgrowth in response to epidermal growth factor and nerve
growth factor in PC12 cells. [Cell Growth Diff.]{.underline} 10:
183-191, 1999.

260\. Szallasi, A., Biro, T., Szabo, T., Modarres, S., Petersen, M.,
Klusch, A., Blumberg, P.M., Krause, J.E. and Sterner, O. A non-pungent
triprenyl phenol of fungal origin, scutigeral, stimulates rat dorsal
root ganglion neurons via interaction at vanilloid receptors. [Br. J.
Pharmacol.]{.underline} 126: 1351-1358, 1999.

261. Romanova, L.Y., Alexandrov, I.A., Blagosklonny, M.V., Nordan, R.P.,
     Garfield, S., Acs, P., Nguyen, P.M., Trepel, J., Blumberg, P.M. and
     Mushinski, J.F. Regulation of actin cytoskeleton in lymphocytes:
     PKC-delta disrupts IL-3-induced membrane ruffles downstream of
     Rac1. [J. Cell. Physiol.]{.underline} 179: 157-169, 1999.

262. Szallasi, A. and Blumberg, P.M. Vanilloid (capsaicin) receptors and
     mechanisms. [Pharmacol. Rev.]{.underline} 51: 159 -212, 1999.

263. Marquez, V.E., Nacro, K., Benzaria, S., Lee, J., Sharma, R., Teng,
     K., Milne, G.W.A., Bienfait, B., Wang, S., Lewin, N.E. and
     Blumberg, P.M. The transition from a pharmacophore-guided approach
     to a receptor-guided approach in the design of potent protein
     kinase C ligands. [Pharmac. Therap.]{.underline} 82: 251-261, 1999.

264. Ma, D.W., Wang, C.Q., Wang, S.M., Kozikowski, A.P., Lewin, N.E.,
     and Blumberg, P.M. Synthesis and protein kinase C binding activity
     of benzolactam-V7. [Bioorg. Med. Chem. Lett.]{.underline} 9:
     1371-1374, 1999.

265. Bögi, K., Lorenzo, P.S., Ács, P., Szállási, Z., Wagner, G.S., and
     Blumberg, P.M. Comparison of the roles of the C1a and C1b domains
     of protein kinase C alpha in ligand induced translocation in NIH
     3T3 cells. [FEBS Lett.]{.underline} 456, 27-30, 1999.

266. Szallasi, A., Blumberg, P.M., Annicelli, L.L., Krause, J.E., and
     Cortright, D.N. The cloned rat vanilloid receptor VR1 mediates both
     R-type binding and C-type calcium response in dorsal root ganglion
     neurons. [Mol. Pharmacol.]{.underline} 56: 581-587, 1999.

267. Swann, P.G., Odom, S., Zhou, Y.J., Szallasi, Z., Blumberg, P.M.,
     Draber, P. and Rivera, J. Requirement for a negative charge at
     threonine 60 of the FcR for complete activation of Syk. [J. Biol.
     Chem.]{.underline} 274: 23068-23077, 1999.

268. Wang, S., Liu, M., Lewin, N.E., Lorenzo, P.S., Bhattacharyya, D.,
     Qiao, L., Kozikowski, A.P., Milne, G.W.A. and Blumberg, P.M.
     Probing the binding of indolactam-V to protein kinase C through
     site-directed mutagenesis and computational docking simulations.
     [J. Med. Chem.]{.underline} 42: 3436-3446, 1999.

269. Szabo, T., Olah, Z., Iadarola, M.J. and Blumberg, P.M. Epidural
     resiniferatoxin induced prolonged regional analgesia to pain.
     [Brain Res.]{.underline} 840: 92-98, 1999.

270. Szallasi, A., Szabo, T., Biro, T., Modarres, S., Blumberg, P.M.,
     Krause, J.E., Cortright, D.N. and Appendino, G. Phorbol
     12,13-didecanoate 20-homovanillate, a resiniferatoxin-type
     vanilloid, shows capsaicin-like selectivity for calcium uptake over
     binding at native vanilloid receptors on rat dorsal root ganglion
     neurons and in CHO cells transfected with the cloned vanilloid
     receptor VR1. [Br. J. Pharmacol.]{.underline} 128: 428-434, 1999.

271. Lee, J., Kang, J.H., Lee, S.Y., Han, K.C., Torres, C.M.,
     Bhattacharyya, D.K., Blumberg, P.M. and Marquez, V.E. Protein
     kinase C ligands based on tetrahydrofuran templates containing a
     new set of phorbol ester pharmacophores. [J. Med.
     Chem.]{.underline} 42: 4129-4139, 1999.

272. Caloca, M.J., Garcia-Bermejo, M.L., Blumberg, P.M., Lewin, N.E.,
     Kremmer, E., Mishak, H., Wang, S., Nacro, K., Bienfait, B.,
     Marquez, V.E. and Kazanietz, M.G. 2-chimaerin is a novel target for
     diacylglycerol: binding properties and changes in subcellular
     localization mediated by ligand binding to its C1 domain. [Proc.
     Natl. Acad. Sci. USA]{.underline} 96: 11854-11859, 1999.

273. Winkler, J.D., Kim, S., Harrison, S., Lewin, N.E. and Blumberg,
     P.M. Synthesis and biological evaluation of highly functionalized
     analogs of ingenol. [J. Am. Chem. Soc.]{.underline} 121: 296-300,
     1999.

274. Lee, J., Park, S.W., Kim, J.Y., Kim, J.K., Lee, J., Oh,U., Marquez,
     V.E., Beheshti, M., Wang, Q.J., Modarres, S., and Blumberg, P.M.
     3-Acyloxy-2-phenalkylpropyl amides and esters of homovanillic acid
     as novel vanilloid receptor agonists. [Bioorg. Med. Chem.
     Letters.]{.underline} 9: 2909-2914, 1999.

275. Li, L., Lorenzo, P.S., Bogi, K., Blumberg, P.M., and Yuspa, S.H.
     PKC targets mitochondria, alters mitochondrial membrane potential
     and induces apoptosis in normal and neoplastic keratinocytes when
     overexpressed by an adenoviral vector. [Mol. Cell
     Biol.]{.underline} 19: 8547-8558, 1999.

276. Wang, Q.J., Bhattacharyya, D.K., Garfield, S., Marquez, V.E. and
     Blumberg, P.M. Differential localization of protein kinase C by
     phorbol esters and related compounds using a fusion protein with
     green fluorescent protein. [J. Biol. Chem.]{.underline} 274:
     37233-37239, 1999.

277. Lorenzo, P.S., Bogi, K., Hughes, K.M., Beheshti, M., Garfield,
     S.H., Pettit, G.R. and Blumberg, P.M. Differential roles of the
     tandem C1 domains of PKC in the biphasic down-regulation induced by
     bryostatin 1. [Cancer Res]{.underline}. 59: 6137-6144, 1999.

278. Nacro, K., Bienfait, B., Lee, J., Han, K.C., Kang, J.H., Benzaria,
     S., Lewin, N.E., Bhattacharyya, D.K., Blumberg, P.M. and Marquez,
     V.E. Conformationally constrained analogues of diacylglycerol
     (DAG). 16. How much structural complexity is necessary for
     recognition and high binding affinity to protein kinase C? [J. Med.
     Chem.]{.underline} 43: 921-944, 2000.

279. Blumberg, P.M., Acs, P., Bhattacharyya, D.K., and Lorenzo, P.S.
     Inhibitors of protein kinase C and related receptors for the
     lipophilic second messenger sn-1,2-diacylglycerol. In: [Signal
     Transduction and Cell Cycle Inhibitors]{.underline}, ed. J.S.
     Gutkind, Humana Press, Totowa, N.J., 2000, pp. 347-364.

280. Nacro, K., Bienfait, B., Lewin, N.E., Blumberg, P.M., and Marquez,
     V.E. Diacylglycerols with lipophilically equivalent branched acyl
     chains display high affinity for protein kinase C (PK-C). A direct
     measure of the effect of constraining the glycerol backbone in DAG
     lactones. [Bioorg. Med. Chem. Lett]{.underline}. 10: 653-655, 2000.

281. Mezey, E., Toth, Z.E., Cortright, D.N., Arzubi, M.K., Krause, J.E.,
     Elde, R., Guo, A., Blumberg, P.M., and Szallasi, A. Distribution of
     mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like
     immunoreactivity, in the central nervous system of the rat and man.
     [Proc. Natl. Acad. Sci. U.S.A.]{.underline} 97: 3655-3660, 2000.

282. Wang, Q.J., Fang, T.W., Fenick, D., Garfield, S., Bienfait, B.,
     Marquez, V.E., and Blumberg, P.M. The lipophilicity of phorbol
     esters as a critical factor in determining the pattern of
     translocation of protein kinase C fused to a green fluorescent
     protein. [J. Biol. Chem.]{.underline} 275: 12136-12146, 2000.

283. Lorenzo, P.S., Beheshti, M., Pettit, G.R., Stone, J.C., and
     Blumberg, P.M. The guanine nucleotide exchange factor RasGRP is a
     novel, high affinity target for diacylglycerol and phorbol esters.
     [Mol. Pharmacol.]{.underline} 57: 840-846, 2000.

284. Acs, P., Beheshti, M., Szallasi, Z., Li, L., Yuspa, S.H., and
     Blumberg, P.M. Effect of tyrosine 155 to phenylalanine mutation of
     protein kinase C on the proliferative and tumorigenic properties of
     NIH 3T3 cells. [Carcinogenesis]{.underline} 21: 887-891, 2000.

285. Ebinu, J.O., Stang, S.L., Teixeira, C., Bottorff, D.A., Blumberg,
     P.M., Barry, M., Bleakley, C., Ostergaard, H.L., and Stone, J.C.
     RasGRP links T cell receptor signaling to Ras. [Blood]{.underline}
     95: 3199-3203, 2000.

286. Tamamura, H., Bienfait, B., Nacro, K., Lewin, N.E., Blumberg, P.M.,
     and Marquez, V.E. Conformationally constrained analogues of
     diacylglycerol (DAG). 17. The contrast between *sn-*1 and *sn-*2
     DAG lactones in binding to protein kinase C (PK-C). [J. Med.
     Chem.]{.underline} 43: 3210-3217, 2000.

287. Kronfeld, I., Kazimirsky, G., Lorenzo, P.S., Garfield, S.H.,
     Blumberg, P.M., and Brodie, C. (1999) Phosphorylation of PKC on
     distinct tyrosine residues regulates different cellular responses.
     [J. Biol. Chem]{.underline}. 275 (45): 35491-35498, 2000.

288. Lee, J., Lee, J., Kim, J., Kim, S.Y., Chun, M.W., Cho, H., Hwang,
     S.W., Oh, U., Park, Y.H., Marquez, V.E., Beheshti, M., Szabo, T.,
     and Blumberg, P.M.
     N-(3-Acyloxy-2-benzylpropyl)-N'-(4-hydroxy-3-methoxybenzyl)thiourea
     derivatives as potent vanilloid receptor agonists and analgesics.
     [Bioorg. Med. Chem.]{.underline} 9 (1): 19-32, 2001.

289. Lorenzo, P.S., Kung, J.W, Bottorff, D.A., Garfield, S.H., Stone,
     J.C., and Blumberg, P.M. Phorbol esters modulate the Ras exchange
     factor RasGRP3. [Cancer Res.]{.underline} 61: 943-949, 2001.

290. Lee, J., Han, K.E., Lee, S.Y., Kim, S.Y., Kang, J.H., Lewin, N.E.,
     Best, L.S., Blumberg, P.M., and Marquez, V.E.
     5-acyloxy-5-hydroxymethyltetrahydro-2-furancarboxylate as a novel
     template for protein kinase C (PKC) binding. [Il
     Farmaco]{.underline} 56: 203-210, 2001.

291. Pak, Y., Enyedy, I., Varady, J., Kung, J.W., Lorenzo, P.S.,
     Blumberg, P.M., and Wang, S. Structural basis of binding of high
     affinity ligands to protein kinase C: prediction of the binding
     modes through a new molecular dynamics method and evaluation by
     site-directed mutagenesis. [J. Med. Chem.]{.underline} 44:
     1690-1701, 2001.

292. Nacro, K., Sigano, D.M., Yan, S., Nicklaus, M.C., Pearce, L.L.,
     Lewin, N.E., Blumberg, P.M., and Marquez, V.E. A small
     combinatorial library helps identify the ideal diacylglycerol
     ligand for protein kinase C that combines the highest binding
     affinity (Ki) and the lowest lipophilicity. [J. Med.
     Chem.]{.underline} 44: 1892-1904, 2001.

293. Mandil, R., Ashkenazi, E., Blass, M., Kronfeld, I., Kazimirsky, G.,
     Rosenthal,G., Umansky, F., Lorenzo, P.S., Blumberg, P.M., and
     Brodie, C. Protein kinase C and protein kinase C play opposite
     roles in the proliferation and apoptosis of glioma cells. [Cancer
     Res.]{.underline} 61: 4612-4619, 2001.

294. Wang, Q.J., Fang, T.-W., Nacro, K., Wang, S., Marquez, V.E., and
     Blumberg, P.M. Role of hydrophobic residues in the C1b domain of
     protein kinase C on ligand and phospholipid interactions. [J. Biol.
     Chem.]{.underline} 276: 19580-19587, 2001.

295. Olah, Z., Szabo, T., Karai, L., Hough, C., Fields, R.D., Caudle,
     R.M., Blumberg, P.M. and Iadarola, M.J. Ligand-induced dynamic
     membrane changes and cell deletion conferred by vanilloid receptor
     [J. Biol. Chem.]{.underline} 276: 11021-11030, 2001.

296. Lee, J., Lee, J., Szabo, T., Gonzalez, A.F., Welter, J.D., and
     Blumberg, P.M. N-(3-acyloxy-2-benzylpropyl)-N'-dihydroxy
     tetrahydrobenzazepine and tetrahydroisoquinoline thiourea analogues
     as vanilloid receptor ligands. [Bioorg. Med. Chem.]{.underline} 9:
     1713-1720, 2001.

297. Kedei, N., Szabo, T., Lile, J.D., Treanor, J.J., Olah, Z.,
     Iadarola, M.J., and Blumberg, P.M. Analysis of the native
     quaternary structure of vanilloid receptor 1. [J. Biol.
     Chem.]{.underline} 276: 28613-28619, 2001.

298. Shao, L., Lewin, N.E., Lorenzo, P.S., Hu, Z., Garfield, S.H.,
     Stone, J.C., Marner, F.-J., Blumberg, P.M., and Wang, S. Iridals
     are a novel class of ligands for phorbol ester receptors with with
     modest selectivity for the RasGRP receptor subfamily. [J.Med.
     Chem.]{.underline} 44: 3872-3880, 2001.

299. Kuzhikandathil, E.V., Wang, H., Morozova, N., Szabo, T., Blumberg,
     P.M., and Oxford, G.S. Conserved residues in the putative sixth
     transmembrane domain of the capsaicin receptor (VR1) are critical
     for function. [J. Neuroscience]{.underline} 21: 8697-8706, 2001.

300. Lee, J., Han, K.C., Kang, J.H., Pearce, L.L., Lewin, N.E., Yan, S.,
     Benzaria, S., Nicklaus, M.C., Blumberg, P.M., and Marquez, V.E.
     Conformationally constrained analogues of diacylglycerol. 18. The
     incorporation of a hydroxamate moiety into DAG-Lactones reduces
     lipophilicity and helps discriminate between *sn*-1 and *sn*-2
     binding modes to protein kinase C (PK-C). Implications for isozyme
     specificity. \[published erratum in [J. Med. Chem]{.underline}.
     46(13): 2794, 2003\] [J. Med. Chem.]{.underline} 44: 4309-4312,
     2001.

301. Ma, D., Zhang, T., Wang, G., Kozikowski, A.P., Lewin, N.E., and
     Blumberg, P.M. Synthesis of 7,8-disubstituted benzolactam-V8 and
     its binding to protein kinase C. Bioorg. Med. Chem. Lett 11(2):
     99-101, 2001.

302. Gracia-Bermejo, M.L., Leskow, F.C., Fujii, T., Wang, Q., Blumberg,
     P.M., Ohba, M., Kuroki, T., Lee, J., Marquez, V.E., and Kazanietz,
     M.G. DAG lactones, a new class of PKC agonists, induce apoptosis in
     LNCaP prostate cancer cells by selective activation of PKC.
     \[published erratum in [J. Biol. Chem]{.underline}. 279: 23846,
     2004\] [J. Biol. Chem.]{.underline} 277: 645-655, 2002.

303. Blass, M., Kronfeld, I., Kazimirsky, G., Blumberg, P.M., and
     Brodie, C. Phosphorylation of PKC is essential for its apoptotic
     effect in response to etoposide. [Mol. Cell. Biol.]{.underline} 22:
     182-195, 2002.

304. Lee, J., Lee, J., Kang, M.S., Kim, K.P., Chung, S., Blumberg, P.M.,
     Yi, J.B., and Park, Y.H. Phenolic modification as an approach to
     improve the pharmacology of 3-acyloxy-2-benzylpropyl homovanillic
     amides and thioureas, a promising class of vanilloid receptor
     agonists and analgesics, [Bioorg. Med. Chem]{.underline}. 10:
     1171-1179, 2002.

305. Szabo, T., Biro, T., Gonzalez, A.F., Palkovits, M., and Blumberg,
     P.M. Pharmacological characterization of vanilloid receptor located
     in the brain. [Mol. Brain Res.]{.underline} 98: 51-57, 2002.

306. Rong, S.-B., Enyedy, I.J., Qiao, L., Zhao, L., Ma, D., Pearce,
     L.L., Lorenzo, P.S., Stone, J.C., Blumberg, P.M., Wang, S., and
     Kozikowski, A.P. Structural basis of RasGRP binding to high
     affinity PKC ligands. [J. Med. Chem.]{.underline} 45: 853-869,
     2002.

307. Joseloff, E. Cataisson, C., Aamodt, H., Ocheni, H., Blumberg, P.M.,
     Kraker, A.J., and Yuspa, S.H. Src family kinases phosphorylate PKC
     on tyrosine residues and moddify the neoplastic phenotype of skin
     keratinocytes. [J. Biol. Chem.]{.underline} 277: 12318-12323, 2002.

308. Toth, A., Kedei, N., Szabo, T., Wang, Y., and Blumberg, P.M.
     Thapsigargin binds to and inhibits the cloned vanilloid receptor 1.
     [Biochem. Biophys. Res. Commun.]{.underline} 293: 777-782, 2002.

309. Nacro, K., Lee, J., Barchi, J.J. Jr., Lewin, N.E., Blumberg, P.M.,
     and Marquez, V.E. Conformationally constrained analogues of
     diacylglycerol (DAG). 19. Asymmetric syntheses of (3R)- and
     (3S)-3-hydroxy-4,4-disubstituted heptono-1,4-lactones as protein
     kinase C (PK-C) ligands with increased hydrophilicity.
     [Tetrahedron]{.underline} 58: 5335-5345, 2002.

310. Di Marzo, V., Blumberg, P.M., and Szallasi, A. Endovanilloid
     signaling in pain. [Curr. Opin. Neurobiol.]{.underline} 12:
     372-379, 2002.

311. Wei, Z.L., Sakamuri, S., Petukhov, P., Sakamuri, S., George, C.,
     Lewin, N.E., Blumberg, P.M., and Kozikowski, A.P. Synthesis and
     modeling study of (2S,5R,6R)- and
     (2S,5R,6S)-6-hydroxy-8-(1-decynyl)-benzolactam-V8 as protein kinase
     C modulators. [Org. Lett.]{.underline} 4: 2169-2172, 2002.

312. Zrachia, A., Dobroslav, M., Blass, M., Kazimirsky, G., Kronfeld,
     I., Blumberg, P.M., Kobiler, D., Lustig, S., and Brodie, C.
     Infection with Sindbis virus induces selective activation and
     tyrosine phosphorylation of PKC. Implications for Sindbis
     virus-induced apoptosis. [J. Biol. Chem.]{.underline} 277:
     23693-23701, 2002.

313. Wang, Y., Szabo, T., Welter, J.D., Toth, A., Tran, R., Lee, J.,
     Kang, S.U., Suh, Y.G., Blumberg, P.M., and Lee, J. High affinity
     antagonists of vanilloid receptor. [\[published erratum appears in
     Mol. Pharmacol 63: 958, 2003\] Mol. Pharmacol.]{.underline}
     62:947-956, 2002.

314. Pettit, G.R., Ducki, S., Tan, R., Gardella, R.S., McMahon, J.B.,
     Boyd, M.R., Pettit, G.R. III, Blumberg, P.M., Lewin, N.E., Doubek,
     D.L., Tackett, L.P., and Williams, M.D. Isolation and structure of
     pedilstatin from a Republic of Maldives *Pedilanthus sp.* [J. Nat.
     Prod.]{.underline} 65: 1262-1265, 2002.

315. Brodie, C., and Blumberg, P.M. Regulation of cell apoptosis by
     protein kinase C . [Apoptosis]{.underline} 8: 19-27, 2003.

316. Kozikowski, A..P., Nowak, I., Petukhov, P.A., Etcheberrigaray, R.,
     Mohamed, A., Tan, M., Lewin, N.E., Hennings, H., Pearce, L.V., and
     Blumberg, P.M. New amide-bearing benzolactam-based PKC modulators
     induce enhanced secretion of the amyloid precursor protein
     metabolite sAPP-. [J. Med. Chem.]{.underline}46: 364-373, 2003.

317. Clark, A.S., West, K., Blumberg, P.M., and Dennis, P.A. Altered PKC
     isoforms in NSCLC cells: PKC promotes cellular survival and
     chemotherapeutic resistance. [Cancer Res.]{.underline} 63 (4):
     780-786, 2003.

318. Sigano, D.M., Peach, M.L., Nacro, K., Choi, Y., Lewin, N.E.,
     Nicklaus, M.C., Blumberg, P.M., and Marquez, V.E., Differential
     binding modes of diacylglycerol (DAG) and DAG-lactones to protein
     kinase C (PK-C). [J. Med. Chem.]{.underline} 46: 1571-1579, 2003.

319. Kang, J.H., Chung, H.E., Kim, S.Y., Kim, Y., Lee, J., Lewin, N.E.,
     Pearce, L.V., Blumberg, P.M., and Marquez, V.E. Conformationally
     constrained analogues of diacylglycerol (DAG). Effect on protein
     kinase C (PK-C) binding by the isosteric replacement of sn-1 and
     sn-2 esters in DAG-lactones. [Bioorg. Med. Chem.]{.underline} 11:
     2529-2539, 2003.

320. Toth, A., Kedei, N., Wang, Y., and Blumberg, P.M. Arachidonyl
     dopamine as a ligand for the vanilloid receptor VR1 of the rat.
     [Life Sci.]{.underline} 73: 487-498, 2003.

321. Choi, Y., Kang, J.H., Lewin, N.E., Blumberg, P.M., Lee, J., and
     Marquez, V.E. Conformationally constrained analogues of
     diacylglycerol. 19. Synthesis and protein kinase C (PK-C) binding
     affinity of DAG-lactones bearing an N-hydroxylamide side chain. [J.
     Med. Chem.,]{.underline} 46(13): 2790-2793, 2003.

322. Lewin, N.E., and Blumberg, P.M. \[^3^H\]phorbol 12,13-dibutyrate
     binding assay for protein kinase C and related proteins. [Methods
     Mol. Biol.]{.underline} 233: 129-156, 2003 (Protein kinase C
     protocols, Vol 233, ed. Alexandra C. Newton, Humana Press, Totowa,
     N.J. pp. 129-156, 2003)

323. Marquez, V.E., and Blumberg, P.M. Diacylglycerol (DAG) and
     DAG-lactones as selective activators of protein kinase C (PK-C).
     [Accounts Chem. Res.]{.underline} 36(6): 434-443, 2003.

324. Lee, J., Lee, J., Kang, M., Shin, M.Y., Kim, J.M., Kang, S.U., Lim,
     J.O., Choi, H.K,, Suh, Y.G., Park, H.K., Oh, U., Kiim, H.D., Park,
     Y.H., Ha, H.J., Kim, Y.H.,, Toth, A., Tran, R., Wang, Y., Pearce,
     L.V., Lundberg, D.J., and Blumberg, P.M.
     N-(3-acyloxy-2-benzylpropyl)-N'-\[4-(methylsulfonylamino)benzyl\]thiourea
     analogues: novel potent and high affinity antagonists and partial
     agonists of the vanilloid receptor. [J. Med. Chem.]{.underline} 46:
     3116-3126, 2003.

325. Hyman, T., Huizing, M., Blumberg, P.M., Falik-Zaccai, T.C.,
     Anikster, Y, and Gahl, W.A. Use of a cDNA microarray to determine
     molecular mechanisms involved in gray platelet syndrome. [Br. J.
     Haematol.]{.underline} 122(1): 142-149, 2003.

326. Wang, Y., Toth, A., Tran, R., Szabo, T., Welter, J.D., Blumberg,
     P.M., Lee, J, Kang, S.U., Lim,J.O., and Lee, J. High affinity
     partial agonists of the vanilloid receptor. [Mol.
     Pharmacol.]{.underline} 64: 325-333, 2003.

327. Bocklandt, S., Blumberg, P.M., and Hamer, D.H., Activation of
     latent HIV-1 expression by the potent anti-tumor promoter
     12-deoxyphorbol 13-phenylacetate. [Antiviral Research]{.underline}
     59(2): 89-98, 2003.

328. Sridhar J., Wei, Z.L., Nowak, I., Lewin, N.E., Ayres, J., Pearce,
     L.V., Blumberg, P.M., and Kozikowski, A.P. New bivalent PKC ligands
     linked by a carbon spacer: enhancement in binding affinity. [J.
     Med. Chem.]{.underline} 46(19): 4196-4204, 2003.

329. Hamer, D.H., Bocklandt, S., McHugh, L., Chun, T.W., Blumberg, P.M.,
     Sigano, D.M., and Marquez, V.E. Rational design of drugs that
     induce human immunodeficiency virus replication. [J.
     Virol.]{.underline} 77(19): 10227-10236, 2003.

330. Lazar, J., Szabo, T., Kovacs, L., Blumberg, P.M., and Biro, T.
     Distinct features of recombinant rat vanilloid receptor 1 expressed
     in various expression systems. [Cell. Mol. Life Sci.]{.underline}
     60 (10):2228-2240, 2003.

331. Wang, Q.J., Fang, T.W., Yang, D., Lewin, N.E., van Lint, J.,
     Marquez, V.E., and Blumberg, P.M. Ligand structure activity
     requirements and phospholipid dependence for the binding of phorbol
     esters to protein kinase D. [Mol Pharmacol.]{.underline} 64:
     1342-1348, 2003.

332. Rambaratsingh, R.A., Stone, J.C., Blumberg, P.M., and Lorenzo, P.S.
     RasGRP1 represents a novel, non-PKC phorbol ester signaling pathway
     in mouse epidermal keratinocytes. [J. Biol. Chem.]{.underline}
     278:52792-52801, 2003.

333. Lee, J., Kang, S.U., Lim, J.O., Choi, H.K., Jin, M.K., Toth, A.,
     Pearce, L.V., Tran, R., Wang, Y., Szabo, T., and Blumberg, P.M.
     N-\[4-(methylsulfonylamino)benzyl\]thiourea analogues as vanilloid
     receptor antagonists: structure activity relationship studies for
     the "C-region". [Bioorg Med. Chem.]{.underline} 12: 371-385, 2004.

334. Toth, A., Blumberg, P.M., Chen, Z., and Kozikowski, A.P. Design of
     a high affinity, competitive antagonist of the vanilloid receptor
     selective for the calcium entry linked receptor population.
     [Molecular Pharmacology]{.underline} 65(2): 282-291, 2004.

335. Tamamura, H., Sigano, D.M., Lewin, N.E., Blumberg, P.M., and
     Marquez, V.E. Conformationally constrained analogues of
     diacylglycerol. 20. The search for an elusive binding site on
     protein kinase C (PK-C) through relocation of the carbonyl
     pharmacophore along the *sn*-1 side chain of
     1,2-diacylglycerol-lactones. [J. Med. Chem.]{.underline}47(3):
     644-655, 2004.

336. Lee, J., Kim, S.Y., Park, S., Lim, J.O., Kim, J.M., Kang, M., Lee,
     J., Kang, S.U., Choi, H.K., Jin, M.K., Welter, J.D., Szabo, T.,
     Tran, R., Pearce, L.V., Toth, A., and Blumberg, P.M. Structure
     activity relationship of simplified resiniferatoxin analogues with
     potent VR1 agonism elucidates an active conformation of RTX for VR1
     binding. [Bioorg. Med Chem.]{.underline} 12:1055-1069, 2004.

337. Lee, J., Kim, S.Y., Kang, J.H., Lewin, N.E., Acs, G., Acs, P.,
     Blumberg, P,M., and Marquez, V.E. Conformationally constrained
     diacylglycerol (DAG) analogues: synthesis of
     4-C-hydroxyethyl-5-O-acyl-2,3-dideoxy-D-glyceropentono-1,4-lactone
     analogues as protein kinase C (PKC) ligands. [Eur. J. Med.
     Chem.]{.underline} 39: 69-77, 2004.

338. Wang, Q.J., Lu, G., Schlapkohl, W., Goerke, A., Larsson, C.,
     Mischak, H., Blumberg, P.M., and Mushinski, J.F. The V5 domain of
     protein kinase C plays a critical role in determining the
     isoform-specific localization, translocation and biological
     functions of protein kinase C- and -. [Mol. Cell. Res.]{.underline}
     2: 129-140, 2004.

339. Pettit, G.R., Hoffmann, H., Herald, D.L., Blumberg, P.M., Hamel,
     E., Schmidt, J.M., Chang, Y., Pettit, R.K., Lewin, N.E., and
     Pearce, L.V. Antineoplastic agents 499. Synthesis of hystatin 2 and
     related 1H-benzo\[de\]\[1,6\]-naphthyridinium salts from aaptamine.
     [J. Med. Chem.]{.underline} 47:1775-1782, 2004.

340. Pettit, G.R., Hoffmann, H., Herald, D.L., McNulty, J., Murphy, A.,
     Higgs, K.C., Hamel, E., Lewin, N.E., Pearce, L.V., Blumberg, P.M.,
     Pettit, R.K., and Knight, J.C. Antineoplastic agents 491. Synthetic
     conversion of aaptamine to isoaaptamine and 9-emethylaaptamine. [J.
     Org. Chem.]{.underline} 69(7):2251-2256, 2004.

341. Lee, J., Kang, S.U., Choi, H.K., Lee, J., Lim, J.O., Kil, M.J.,
     Jin, M.K., Kim, K.P., Chung, S.J., Ha, H.J., Kim, Y.H., Pearce,
     L.V., Tran, R., Lundberg, D.J., Wang, Y., Toth, A., and Blumberg,
     P.M. Analysis of structure activity relationships for the
     "B-region" of
     N-(3-acyloxy-2-benzylpropyl)-N'-\[4-(methylsulfonylamino)benzyl\]thiourea
     analogues as vanilloid receptor antagonists: discovery of an
     N-hydroxythiourea analogue with potent analgesic activity. [Bioorg.
     Med. Chem. Lett.]{.underline} 14:2291-2297, 2004.

342. Lazar, J., Szabo, T., Marincsak, R., Kovacs, L., Blumberg, P.M.,
     and Biro, T. Sensitization of recombinant vanilloid receptor-1 by
     various neurotrophic factors. [Life Sci.]{.underline} 75(2):
     153-163, 2004.

343. Papp, H., Czifra, G. Bodo, E., Lazar, J., Kovacs, I., Aleksza, M.,
     Juhasz, I., Acs, P., Sipka, L., Blumberg, P.M., and Biro, T.
     Opposite roles of protein kinase C isoforms in proliferation,
     differentiation, apoptosis, and tumorigenicity of Human HaCaT
     keratinocytes. [Cell. Mol. Life Sci]{.underline} 61(9): 1095-1105,
     2004.

344. Kedei, N., Lundberg, D.J, Toth, A., Welburn, P., Garfield, S.H.,
     and Blumberg, P.M. Characterization of the interaction of ingenol
     3-angelate with protein kinase C. [Cancer Research]{.underline} 64
     (9): 3245-3255, 2004.

345. Duan, D., Lewin, N.E., Sigano, D.M., Blumberg, P.M., and Marquez,
     V.E. Conformationally constrained analogues of diacylglycerol. 21.
     A solid-phase method of synthesis of Diacylglycerol lactones
     (DAG-lactones) as a prelude to a combinatorial approach for the
     synthesis of protein kinase C (PK-C) isozyme -specific ligands. [J.
     Med. Chem.]{.underline} 47(12): 3248-3245, 2004

346. Gavva, R.R., Klionsky, L., Qu, Y., Shi, L., Tamir, R., Edenson, S.,
     Zhang, T.J., Viswanadhan, V.N., Toth, A., Pearce, L.V., Vanderah,
     T.W., Porreca, F., Blumberg, P.M., Lile, J., Sun, Y., Wild, K.,
     Louis, J.C., and Treanor, J.J.S. Molecular determinants of
     vanilloid sensitivity in TRPV1. [J. Biol. Chem.]{.underline} 279
     (19):20283-20295, 2004.

347. Lee, J., Kim, S.Y., Lee, J., Kang, M., Kil, M.J., Choi, H.K., Jin,
     M.K., Wang, Y., Toth, A., Pearce, L.V., Lundberg, D.J., Tran, R.,
     and Blumberg, P.M. Analysis of structure activity relationships
     with the
     N-(3-acyloxy-2-benzylpropyl)-N'-\[4-(methylsulfonylamino)benzyl\]thiourea
     template for vanilloid receptor 1 antagonism. [Bioorg. Med.
     Chem.]{.underline} **12**: 3411-3420.

348. Kang, J.H., Siddiqui, M.A., Sigano, D. M., Krajewski, K., Lewin,
     N.E., Pu, Y., Blumberg, P.M., Lee, J., and Marquez, V.E.
     Conformationally constrained analogues of diacylglycerol. 24.
     Asymmetric synthesis of a chiral (R)-DAG-Lactone template as a
     versatile precursor for highly functionalized DAG-lactones. [Org.
     Lett.]{.underline} 6(14): 2413-2416, 2004.

349. Brodie, C., Steinhart, R., Kazimirsky, G., Rubinfeld, H., Hyman,
     T., Ayres, J.A., Hur, G.M., Toth, A., Yang, D., Garfield, S.H.,
     Stone, J.C., and Blumberg, P.M. PKC delta associates with and
     phosphorylates RasGRP3 in response to phorbol esters. [Mol.
     Pharmacol.]{.underline} 66(1): 76-84, 2004.

350. Kang, J.H., Kim, S.Y., Lee, J., Marquez, V.E., Lewin, N.E., Pearce,
     L.V., and Blumberg, P.M. Macrocyclic diacylglyerol-bis-lactones as
     conformationally constrained analogues of diacylglycerol-lactones.
     Interactions with protein kinase C. [J. Med. Chem]{.underline}. 47:
     4000-4007, 2004.

351. Pearce, L.V., Petukhov, P.A., Szabo, T., Kedei, N., Bizik, F.,
     Kozikowski, A.P., and Blumberg, P.M. Evodiamine functions as an
     agonist for the vanilloid receptor TRPV1. [Org. Biomol.
     Chem.]{.underline} 2: 2281-2286, 2004.

352. Tamamura, H., Sigano, D.M., Lewin, N.E., Peach, M.L., Nicklaus,
     M.C., Blumberg, P.M., and Marquez, V.E. Conformationally
     constrained analogues of diacylglycerol (DAG). 23. Hydrophobic
     ligand-protein interactions versus ligand-lipid interactions of
     DAG-lactones with protein kinase C (PK-C). [J. Med.
     Chem.]{.underline} 47 (20): 4858-4864, 2004.

353. Wang, Y., Kedei, N., Wang, M., Wang, Q.J., Huppler, A., Toth, A.,
     Tran, R., and Blumberg, P.M. The interaction between PKC mu and the
     vanilloid receptor type 1. [J. Biol. Chem.]{.underline} 279(51):
     53674-53682, 2004.

354. Braun, D.C., Cao, Y., Wang, S., Garfield, S., Hur, G.M., and
     Blumberg, P.M. Role of phorbol ester localization in determining
     protein kinase C or RasGRP3 translocation: real-time analysis using
     fluorescent ligands and proteins. [Mol Cancer Ther.]{.underline}
     4(1): 141-150, 2005.

355. Braun, D.C., Garfield, S.H., and Blumberg, P.M. Analysis by
     fluorescence resonance energy transfer of the interaction between
     ligands and protein kinase C (delta) in the intact cell. [J. Biol.
     Chem.]{.underline} 280 (9): 8164-8171, 2005.

356. Toth, A., Wang, Y., Kedei, N., Tran, R., Pearce, L.V., Kang, S.U.,
     Jin, M.K., Choi, H.K., Lee, J., and Blumberg, P.M. Different
     vanilloid agonists cause different patterns of calcium response in
     CHO cells heterologously expressing rat TRPV1. [Life
     Sci.]{.underline} 76: 2921-2932, 2005.

357. Toth, A., Boczan, J., Kedei, N., Lizanecz, E., Bagi, Z., Papp, Z.,
     Edes, I., Csiba, L., and Blumberg, P.M. Expression and distribution
     of vanilloid receptor 1 (TRPV1) in the adult rat brain. [Mol. Brain
     Res.]{.underline} 135: 162-168, 2005.

358. Okhrimenko, H., Lu, W., Jiang, C., Ju, D., Blumberg, P.M., Gomel,
     R., Kazimirsky, G., and Brodie, C. Role of tyrosine phosphorylation
     and cleavage of PKC in its protective effect against TRAIL-induced
     apoptosis. [J. Biol. Chem.]{.underline}, 280(25): 23643-23652,
     2005.

359. Qiang, Y.W., Walsh, K., Yao, L., Kedei, N., Blumberg, P.M., Rubin,
     J.S., Shaughnessy, J. Jr., Rudikoff, S. Wnts induce
     migration/invasion of myeloma plasma cells. [Blood]{.underline}
     106(5): 1786-1793, 2005 (epub May 10, 2005).

360. Pu, Y., Perry, N.A., Yang, D., Lewin, N.E., Kedei, N., Braun, D.C.,
     Choi, S.H., Blumberg, P,M., Garfield, S.H.,Stone, J.C., Duan, D.,
     and Marquez, V.E. A novel diacylglycerol lactone shows marked
     selectivity in vitro among C1 domains of PKC isoforms and as well
     as selectivity for RasGRP compared to PKC. [J. Biol.
     Chem]{.underline}. 280 (29): 27329-27338, 2005.

361. Lee, J., Jin, M.K., Kang, S.U., Kim, S.Y., Lee, J., Shin, M.,
     Hwang, J., Cho, S., Choi, Y.S., Choi, H.K.,, Kim, S.E., , Suh,
     Y.G., Lee, Y.S., Kim, Y.H., Ha, H.J., Toth, A., Pearce, L.V., Tran,
     R., Szabo, T., Welter, J.D., Lundberg, D.J., Wang, Y., Lazar, J.,
     Pavlyukovets, V.A., Morgan, M.A., and Blumberg, P.M. Analysis of
     structure activity relationships for the "B-region" of
     N-(4-t-butylbenzyl)-4\'-\[4-(methylsulfonylamino)benzyl\]thiourea
     analogues as TRPV1 receptor antagonists. [Bioorg. Med. Chem.
     Lett.]{.underline} 15(18): 4143-4150, 2005 (Epub June 28, 2005).

362. Lee, J., Kang, S.U., Kil, M.J., Shin, M, Lim, J.O., Choi, H.K.,
     Jin, M.K., Kim, S.Y., Kim, S.E., Lee, Y.S., Min, K.H., Kim, Y.H.,
     Ha, H.J., Tran, R., Welter, J.D., Wang, Y., Szabo, T., Pearce,
     L.V., Lundberg, D.J., Toth, A., Pavlyukovets, V.A., Morgan, M.A.,
     and Blumberg, P.M. Analysis of structure activity relationships for
     the "A-region" of
     N-(4-t-butylbenzyl)-4\'-\[4-(methylsulfonylamino)benzyl\]thiourea
     analogues as TRPV1 receptor antagonists. [Bioorg. Med
     .Chem.Lett.]{.underline} 15(18): 4136-4142, 2005 (Epub July 5,
     2005).

363. Blumberg, P.M., Braun, D., Kedei, N., Lazar, J., Pavlyukovets, V.,
     and Pearce, L.V. Insights into TRPV1 pharmacology provided by
     non-capsaicin ligands. In: [Turning up the Heat on Pain: TRPV1
     Receptors in Pain and Inflammation]{.underline}, Progress in
     Inflammation Research, Malmberg, A. B., and Bley, K.R., (Eds.), New
     York, Birkhäuser Verlag, pp. 55-69, 2005.

364. Kang, J.H., Peach, M.L., Pu, Y., Lewin, N.E., Nicklaus, M.C.,
     Blumberg, P.M., and Marquez, V.E. Conformationally constrained
     analogues of diacylglycerol (DAG). 25. Exploration of the sn-1 and
     sn-2 carbonyl functionality reveals the essential role of the
     *sn*-1 carbonyl at the lipid interface in the binding of
     DAG-lactones to protein kinase C. [J. Med. Chem.]{.underline}
     48(18): 5738-5748, 2005.

365. Lee, J., Lee, J.H., Kim, S.Y., Perry, N.A., Lewin, N.E., Ayres,
     J.A., and Blumberg, P.M. 2-benzyl and 2-phenyl-3-hydroxypropyl
     pivalates as protein kinase C ligands. [Bioorg. Med.
     Chem.]{.underline} 14: 2022-2031, 2006 (Epub Nov 14, 2005).

366. Lizanecz, E., Bagi, Z., Paztor, E.T., Papp, Z., Edes, I., Kedei,
     N., Blumberg, P.M., and Toth, A. Phosphorylation dependent
     desensitization of vanilloid receptor-1 (TRPV1) function in rat
     skeletal muscle arterioles and in CHO-TRPV1 cells by anandamide.
     [Mol. Pharmacol.]{.underline} 69: 1015-1023, 2006 (Epub Dec 7,
     2005).

367. Czifra, G., Toth, I.B., Marincsak,R., Juhasz, I., Acs, P.,
     Kovacs,L., Blumberg, P.M., and Biro, T. Insulin-like growth
     factor-I-coupled mitogenic signaling in primary cultured human
     skeletal muscle cells and in C2C12 myoblasts. A central role of
     protein kinase C delta. [Cellular Signaling]{.underline} 18:
     1461-1472, 2006 (Epub Jan 2, 2006).

368. Lazar, J,, Braun, D.C., Toth, A., Wang, Y., Pearce, L.V.,
     Pavlyukovets, V.A., , Blumberg, P.M., Garfield, S.H., Wincovitch,
     S., Choi, H.K., and Lee, J. Kinetics of penetration influence the
     apparent potency of vanilloids on TRPV1. [Mol.
     Pharmacol.]{.underline} 69: 1166-1173, 2006 (Epub. Jan 17, 2006).

369. Lee, J., Kang, J.H., Han, K.C., Kim, Y., Kim, S.Y., Youn, H.S.,
     Mook-Jung, I., Kim, H., Han, J.H.L., Ha, H.J., Kim, Y.H., Marquez,
     V.E., Lewin, N.E., Pearce, L.V., Lundberg, D.J., and Blumberg, P.M.
     Branched DAG-lactones as potent PKC ligands and alpha-secretase
     activators. [J. Med. Chem.]{.underline} 49: 2028-2036, 2006.

370. Kang, J.H., Benzaria, S., Sigano, D.M., Lewin, N.E., Pu, Y.,
     Blumberg, P.M., and Marquez, V.E. Conformationally constrained
     analogues of diacylglycerol (DAG). 26. Aryl groups at *sn*-1 and
     *sn*-2 positions expand the chemical repertoire of diacylglycerol
     lactones and help explore the chemical space surrounding the
     protein kinase C binding site. [J. Med. Chem]{.underline}. 49:
     3185-3203, 2006.

371. Mach, U.R., Lewin, N.E., Blumberg, P.M., and Kozikowski, A.P.,
     Synthesis and pharmacological evaluation of new 8- and
     9-substituted benzolactam V8 derivatives as potential ligands for
     protein kinase C, a therapeutic target for Alzheimer's Disease.
     [Chem. Med. Chem.]{.underline} 1: 307-314, 2006.

372. Choi, C.H., Hyman, T., and Blumberg, P.M. The differential effects
     of bryostatin 1 and phorbol 12-myristate 13-acetate on HOP-92 cell
     proliferation is mediated by down regulation of PKC delta. [Cancer
     Res]{.underline}. 66: 7261-7269, 2006.

373. Pu, Y., Peach, M., Garfield, S.H., Wincovitch, S., Marquez, V.E.,
     and Blumberg, P.M., Effects on ligand interaction and membrane
     translocation of the positively charged arginine residues situated
     along the C1 domain binding cleft in the atypical protein kinase C
     isoforms. [J. Biol. Chem.]{.underline} 281: 33773-33788, 2006
     (Epub. Sept 1, 2006).

374. Szallasi, A., and Blumberg, P.M. Complex regulation of TRPV1 by
     vanilloids. In: [TRP ion channel function in sensory transduction
     and cellular signaling cascades]{.underline}, Liedtke, W., and
     Heller, S. (Ed.). , pp. 85 -104,CRC Press, Ltd, Boca Raton, FL.,
     2006.

375. Kang, D.W., Ryu, H.C., Lee, J., Lang, K.A., Pavlyukovets, V.A.,
     Pearce, L.V., Ikeda, T., Lazar, J., and Blumberg, P.M. Halogenation
     of 4-hydroxy-3-methoxybenzyl thiourea TRPV1 agonists showed
     enhanced antagonism to capsaicin. [Bioorg. Med.
     Chem.Lett.]{.underline} 17: 214-219, 2007 (Epub Oct 9, 2006)

376. Malolanarasimhan, K., Kedei, N., Sigano, D.M., Kelley, J.A., Lai,
     C.C., Lewin, N.E., Surawski, R.J., Pavlyukovets, V.A. Garfield,
     S.H., Wincovitch, S., Blumberg, P.M., and Marquez, V.E.
     Conformationally constrained analogues of diacylglycerol (DAG). 27.
     Modulation of membrane translocation of protein kinase C (PKC)
     isozymes and by diacylglycerol lactones (DAG-lactones) containing
     rigid-rod acyl groups. [J. Med. Chem.]{.underline} 50: 962-978,
     2007 (Epub Feb. 7, 2007).

377. Tang, L., Chen, Y., Chen, Z., Blumberg, P.M., Kozikowski, A.P., and
     Wang, Z.J. Antinociceptive pharmacology of
     N-(4-chlorobenzyl)-N\'-(4-hydroxy-3-iodo-5-methoxybenzyl) thiourea
     (IBTU), a high affinity competitive antagonist of transient
     receptor potential vanilloid 1 receptor. [J. Pharmacol. Exper.
     Ther.]{.underline} 321(2): 791-798, 2007 (Epub. Feb 20, 2007).

378. Choi, Y.\*, Pu, Y.\*, Peach, M.L.\*, Kang, J.H., Lewin, N.E.,,
     Sigano, D.M., Garfield, S.H., Blumberg, P.M., and Marquez, V.E.
     Conformationally constrained analogues of diacylglycerol (DAG). 28.
     DAG-dioxolanones reveal a new interaction site in the C1b domain of
     PKC delta. [J. Med. Chem.]{.underline} 50: 3465-3481, 2007 (Epub
     6/23/2007).

379. Chung, J.U., Kim, S.Y., Lim, J.O., Choi, H.K., Kang, S.U., Yoon,
     H.S., Ryu, H.C., Kang, D.W., Lee, J., Kang, B., Choi, S., Toth, A.,
     Pearce, L.V., Pavlyukovets, V.A., Lundberg, D.J., and Blumberg,
     P.M, -Substituted
     N-(4-t-Butylbenzyl)-N'-\[4-(methysulfonylamino)benzyl\]thiourea
     analogues as potent and stereospecific TRPV1 antagonists. [Bioorg.
     Med. Chem]{.underline}. 15: 6043-6053, 2007 (epub June 26, 2007).