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| **Name/Title of Meeting: Cancer Redox Biology Steering Committee      |
| Meeting**                                                             |
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| **Date of Meeting: 9/13/06 Location:** 10/B2.5B conference room       |
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| **Head Organizer: David Wink**                                        |
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| **Summary Prepared By: Terry Moody**                                  |
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| Attendance: Drs. D. Wink (chair), S. Ambs, M. Espey, P. Hussain, J.   |
| Mitchell, T. Moody, R. Pluta, D. Roberts, G. Yeh                      |
|                                                                       |
| Dr. Wink outlined the goals of the Cancer Redox Biology Faculty for   |
| the 2006-2007 fiscal year. Dr. Wink presented on Cancer Redox Biology |
| to the NCI NCAB on Sept. 6, 2006. The "Redox Biology" course will     |
| begin on Sept. 26, 2006 in Bldg. 50, Rms. 1227/1233. The course will  |
| occur Tuesday afternoon from 4-6 p.m. for 7 weeks and end Nov. 7,     |
| 2006. The class will be videoconferenced to NCI-Frederick, videocast  |
| live ([http://videocast.nih.gov](http://videocast.nih.gov/)) and      |
| archived. A certificate will be provided to registrants who pass the  |
| final examination. With the larger conference room, we will be able   |
| to accommodate 150 registrants.                                       |
|                                                                       |
| This Fall, Dr. Yeh will organize a seminar on PPARγ for December. Dr. |
| Espey announced that the Oxygen Club of Greater Washington DC will    |
| have a symposium on Oct. 12 and 13, 2006 at NIH Masur Auditorium. In  |
| the Winter, Dr. Wink will organize a seminar on peroxide and          |
| superoxide signaling. In the Spring, Dr. Wink will organize a         |
| workshop on Redox Biology and Inflammation.                           |
|                                                                       |
| Dr. Wink reviewed the research progress on the S-NSAIDs. Dr. Yeh has  |
| found that the S-NSAIDs reduce phase I enzymes and increase phase II  |
| enzymes, resulting in increased degradation of carinogens. Dr.        |
| Roberts has submitted a manuscript for publication showing that the   |
| S-NSAIDs decrease angiogenesis. Dr. Moody has found that the S-NSAIDs |
| decrease PGE2 levels in cancer cells and are cytotoxic for lung,      |
| breast and colon cancer cells. Two animal protocols will be started   |
| this year to see if the S-NSAIDs decrease tumor growth and            |
| carcinogenesis. A collaboration will be conducted with DCP to         |
| evaluate NO-NSAIDs.                                                   |
|                                                                       |
| The next CRBF meeting will be held on Oct. 11 at 4 p.m. in the B2.5   |
| conference room.                                                      |
|                                                                       |
| Action items: Dr. Moody will advertise the Redox Biology course using |
| the NIH ListServ. Dr. Yeh will contact Dr. Gonzales about the         |
| December seminar.                                                     |
|                                                                       |
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