**[Task Description]{.underline}**

The NCATS will total \$25,000

Dates August 29, 2007-August 28, 2008

Firm will issue 12 checks, check amounts:

September 15, 2007 - \$2,500

October 15, 2007 -- July 15, 2008 - \$2,000

August 15, 2008 - \$2,500

Checks will be sent to Kantima Leelahavanichkul from the Faculty of
Dentistry, Thammasat University, Thailand. Payment to Ms
Leelahavanichkul as Per Diem during her stay at OPCB.

The checks should be sent to the NIDCR for presentation to Kantima
Leelahavanichkul. on or about the 15^th^ of each month September, 2007
through August 2008.

Please send checks attention of Mrs. Lidia Caraballo at the following
address:

Mrs. Lidia Caraballo

30 Convent Drive Room 508

Building 30

Bethesda, MD 20892

Telephone: 301-402-1395

Fax: 301-402-0823

Preparer, Elizabeth Powell, OPCB, NIDCR

Contract expiration date - August 28, 2008

## **STATEMENT OF WORK**

> 1\. [Objectives]{.underline}
>
> The contractor will provide Dr. Silvio Gutkind with professional
> laboratory services. Dr. Kantima Leelahavanichkul's work will focus on
> studying the molecular mechanisms of signal transduction pathways that
> are deregulated in squamous cell carcinomas of the oral cavity. In
> particular, she will examine the contribution of the PI3K-Akt pathway
> to the neoplastic conversion of epithelial cells.
>
> 2\. [Approach]{.underline}
>
> > The contractor will work using transient and stable transfections
> > into murine and human epithelial cells, and engineer transgenic
> > animal lines to express genes under the control of an inducible
> > system to evaluate the contribution of signaling pathways to
> > oncogenesis.
>
> 3\. [Methods]{.underline}
>
> The services that will be performed are as follows.
>
> a\) The contractor will test the function of genes using cloning
> techniques, western blots, northern blots and basic molecular cell
> biology techniques relative to the projects.

b\) The advance techniques will be: Using engineered mice, laser-capture
microdissection, gene arrays, and antibody arrays.

> c\) Keeping careful records of all experiments that were performed.

# Personnel, evaluation and schedule

A.  [Personnel]{.underline}

> The contractor is an expert in primary cell preparations and has
> extensive experience in analytic methodologies with emphasis on those
> used to study carcinogenesis. Personnel provided under the contract
> will comply with the rules and policies of the NIDCR and its staff.

B.  [Evaluation]{.underline}

> The contractor will be evaluated daily and if the contractor is
> considered to be substandard in the judgment of the supervisor, the
> contractor will initially receive notice of the problem from the
> supervisor and will be required to take corrective measures and to
> demonstrate improved performance.

C.  [Schedule]{.underline}

> > The contractor will perform studies for a minimum of 40 hours per
> > week, Monday through Friday. Failure to arrive on time or to follow
> > the time schedules or instructions as indicated shall be considered
> > default of the contract.
>
> [Reporting Requirements]{.underline}
>
> The contractor shall provide professional services for the Oral and
> Pharyngeal Cancer Branch, NIDCR during the period of August 29, 2007
> -- through -- August 28, 2008.
>
> The contractor will be paid a total of \$25,000..