**Table S4:** Association of selected genes with tissue types.

+-------+-------------------------+-----------------------+-----------+
| **G   | **Sample 1 (size) vs.** | **Sample 1 mean (±    | **Pe      |
| ene** |                         | SD) vs.**             | rmutation |
|       | **sample 2 (size)**     |                       | T-test**  |
|       |                         | **sample 2 mean (±    |           |
|       |                         | SD)**                 | **P       |
|       |                         |                       | value**   |
+-------+-------------------------+-----------------------+-----------+
| ##    | ## L                    | ## 4.1 (± 0           | 0.0393    |
| ABCA3 | ung cancer: H522, A549, | .9) vs. -0.3 (± 3.7)  |           |
|       |  EKVX (3) vs. rest (56) |                       |           |
+-------+-------------------------+-----------------------+-----------+
| ##    | ###                     | ## 2.4 (± 3           | 0.0059    |
| ABCB1 | Renal (8) vs. else (51) | .6) vs. -0.6 (± 2.4)  |           |
+-------+-------------------------+-----------------------+-----------+
| ## AB | Renal (8) vs. else (51) | ## 0.5 (± 0.          | 0.3705    |
| CC4\* |                         | 6) vs. -0.04 (± 2.3)  |           |
+-------+-------------------------+-----------------------+-----------+
|       | Melanoma (10) vs. else  | ## 0.7 (± 1           | 0.2164    |
|       | (49)                    | .1) vs. -0.1 (± 2.3)  |           |
+-------+-------------------------+-----------------------+-----------+
|       | Breast (5) vs. else     | ## -2.9 (±            | 0.0161\*  |
|       | (54)                    | 6.2) vs. 0.3 (± 1.1)  |           |
+-------+-------------------------+-----------------------+-----------+
|       | Prostate (2) vs. else   | ## 0.4 (±             | 0.6586    |
|       | (57)                    | 0.7) vs. 0.03 (± 2.2) |           |
+-------+-------------------------+-----------------------+-----------+
|       | CNS (6) vs. else (53)   | ## -0.2 (±            | 0.6734    |
|       |                         | 1.0) vs. 0.1 (± 2.2)  |           |
+-------+-------------------------+-----------------------+-----------+
|       | Leukemia (6) vs. else   | ## 0.4 (± 1.1         | 0.4998    |
|       | (53)                    | ) vs. -0.004 (± 2.2)  |           |
+-------+-------------------------+-----------------------+-----------+
|       | Lung (9) vs. else (50)  | ## -0.3 (±            | 0.5603    |
|       |                         | 1.3) vs. 0.1 (± 2.3)  |           |
+-------+-------------------------+-----------------------+-----------+
|       | Colon (7) vs. else (52) | ## -0.1 (±            | 0.7918    |
|       |                         | 0.8) vs. 0.1 (± 2.2)  |           |
+-------+-------------------------+-----------------------+-----------+
|       | Ovarian (6) vs. else    | ## 1.0 (± 1           | 0.1444    |
|       | (53)                    | .2) vs. -0.1 (± 2.2)  |           |
+-------+-------------------------+-----------------------+-----------+
| ##    | Renal (8) vs. else (51) | ## 0.3 (± 0           | 0.2364    |
| ABCA2 |                         | .7) vs. -0.06 (± 0.9) |           |
+-------+-------------------------+-----------------------+-----------+
|       | Melanoma (10) vs. else  | ## -0.1 (±            | 0.6873    |
|       | (49)                    | 0.5) vs. 0.01 (± 0.9) |           |
+-------+-------------------------+-----------------------+-----------+
|       | Breast (5) vs. else     | ## 0.1 (± 0           | 0.7135    |
|       | (54)                    | .5) vs. -0.02 (± 0.9) |           |
+-------+-------------------------+-----------------------+-----------+
|       | Prostate (2) vs. else   | ## 1.1 (± 0           | 0.068     |
|       | (57)                    | .5) vs. -0.04 (± 0.9) |           |
+-------+-------------------------+-----------------------+-----------+
|       | CNS (6) vs. else (53)   | ## -0.4 (±            | 0.2448    |
|       |                         | 0.8) vs. 0.03 (± 0.9) |           |
+-------+-------------------------+-----------------------+-----------+
|       | Leukemia (6) vs. else   | ## -0.4 (±            | 0.2972    |
|       | (53)                    |  1.3) vs.0.03 (± 0.8) |           |
+-------+-------------------------+-----------------------+-----------+
|       | Lung (9) vs. else (50)  | ## 0.04 (±            | 0.8492    |
|       |                         | 1.1) vs.-0.01 (± 0.8) |           |
+-------+-------------------------+-----------------------+-----------+
|       | Colon (7) vs. else (52) | ## -0.4 (±            | 0.1879    |
|       |                         | 0.9) vs. 0.04 (± 0.9) |           |
+-------+-------------------------+-----------------------+-----------+
|       | Ovarian (6) vs. else    | ## 0.4 (± 0           | 0.2559    |
|       | (53)                    | .6) vs. -0.05 (± 0.9) |           |
+-------+-------------------------+-----------------------+-----------+

\* Based on the step-down Bonferroni-Holm multiple comparison procedure,
the adjusted p value is **0.1449**