-------------- ----------------- -------------- ---------------- ---------------
  **DNA**        **Inheritance**   **The Human    **Ethical,       **Potpourri**
                                   Genome**       Legal, and       
                                                  Social           
                                                  Implications**   

  **100**        **100**           **100**        **100**          **100**

  **200**        **200**           **200**        **200**          **200**

  **300**        **300**           **300**        **300**          **300**

  **400**        **400**           **400**        **400**          **400**

  **500**        **500**           **500**        **500**          **500**
  -------------- ----------------- -------------- ---------------- ---------------

**[Basic Concepts]{.underline}**

[100]{.underline}

Q: DNA is organized into segments called \_\_\_\_\_\_\_\_\_.

A: Genes

[200]{.underline}

Q: The nucleotides, or building blocks, of DNA are represented by these
4 letters

A: A, T, C, G (follow-up question: what do these letters stand for?)

[300]{.underline}

Q: The structure of DNA was discovered by these two men

A: James Watson & Francis Crick (follow-up question: what was that
structure? Ans: double helix) Side note: this discovery would have been
impossible without contributions from Maurice Wilkins and Rosalind
Franklin

[400]{.underline} **(Double Jeopardy question -- students can wager
points)**

Q: A single DNA molecule has these three components

A: Nucleotide base, sugar group, phosphate group

[500]{.underline}

Q: The process in which DNA is converted to RNA is called this

A: Transcription (follow-up question: and the process that converts RNA
into proteins? Ans: translation)

**[Inheritance]{.underline}**

[100]{.underline}

Q: This kind of diagram is often drawn to figure out the possible
combinations of genes if two particular individuals mate

A: Punnett square

[200]{.underline}

Q: This man is considered the father of modern genetics

A: Gregor Mendel (follow-up question: what organisms did he experiment
upon to come up with his principles of heredity? Ans: pea plants)

[300]{.underline}

Q: This type of phenotype can *only* be expressed if the genotype is
homozygous for an allele

A: Recessive

[400]{.underline}

Q: If one parent is heterozygous for brown eyes, and the other parent is
homozygous for blue eyes, what is the chance they will have a brown-eyed
child?

A: 50%

[500]{.underline}

Q: On a pedigree, what symbol represents a male who is deceased?

A: A square with a diagonal line through it (can give students option of
drawing it)

**[The Human Genome]{.underline}**

[100]{.underline}

Q: The human genome contains approximately this many nucleotides, or
base pairs

A: 3 billion

[200]{.underline}

Q: This percentage of the DNA sequence is estimated to be unique in
individuals

A: 0.1% (one-tenth of a percent)

[300]{.underline}

Q: It is estimated that human beings have this many genes

A: (Accept any answer between 20,000 to 30,000)

[400]{.underline} **(Double Jeopardy question -- students can wager
points)**

Q: The complete draft sequence of the human genome was finished in April
of this year

A: 2003

[500]{.underline}

Q: The field which studies how your genes affect your individual
response to a certain drug is called this

A: Pharmacogenetics (can accept pharmacogenomics, but explain the subtle
difference)

**[ELSI]{.underline}**

[100]{.underline}

Q: The name of the first mammal cloned using nuclear transfer

A: Dolly

[200]{.underline}

Q: True or false: there are currently laws in place which clearly define
who "owns" an individual's genetic information

A: False

[300]{.underline}

Q: The nature vs. nurture debate could also be called \_\_\_\_\_\_\_ vs.
\_\_\_\_\_\_\_

A: Genes vs. environment

[400]{.underline}

Q: True or false: a physician is legally required to always tell a
patient's family members the results of a genetic test

A: False

[500]{.underline}

Q: True or false: A person with a genetic mutation is always considered
to have a genetic disease

A: False

**[Potpourri]{.underline}**

[100]{.underline}

Q: Nearly every human cell has this many pairs of chromosomes

A: 23 (follow-up question: what are the first 22 pairs called? Ans:
autosomes)

[200]{.underline}

Q: A well-constructed pedigree should show at least this many
generations

A: Three

[300]{.underline}

Q: Name three *common* diseases which have a proven genetic component

A: Cancer, heart disease, stroke, diabetes, etc.

[400]{.underline}

Q: Genes code for individual phenotypes called this

A: Traits

[500]{.underline}

Q: The genes which are most important in determining whether an
individual will be male or female can be found on this chromosome

A: Y

**FINAL JEOPARDY**

Q: What does DNA stand for?

A: Deoxyribonucleic Acid

OR

Q: What is the name of a picture of chromosomes paired and lined up
according to number, with sex chromosomes placed last?

A: Karyotype

**[Suggested Instructions]{.underline}**

This game should only be played with audiences of 30 or fewer students.
Write the categories and point values on the board.

Divide students into groups. Each group should select a "spokesperson."
The spokesperson will be responsible for giving the group's answer and
raising their hand as fast as possible once the group tells them they
know the answer. The groups should also select names for themselves, or
you should assign them as Group 1, Group 2, and Group 3, etc.

Choose any method you want to determine which group gets to select a
category and point value first (first birthday in the class, thinking of
number between 1 & 10, etc.).

Group has 10 seconds to decide on a category and point value. Erase that
point value from the board. Presenter will read the question. Students
may discuss the question within their group. The first spokesperson to
confer with their group and raise their hand gets the chance to answer.
Give the groups a set number of seconds (15 or 30, maybe) to talk over
their answer before calling on the first hand up.

Once you call on the first hand up, have them say their answer out loud.
If it's wrong, the other two groups do not get a chance to discuss the
question with their group any more. If a group still wants to answer the
question after hearing the first guess, the spokesperson must raise his
or her hand and be called on. If the second guess is wrong, the third
spokesperson must raise his or her hand if they want to answer, and so
on. (If the question is true/false, the round ends after the first group
answers, regardless of if they were right or wrong).

Scoring is simple. If a group gets the question right, add the point
value to their total (write it down where everyone can see). If a group
gets the question wrong, subtract the point value from their total --
it's okay to go negative. If no one gets the question right, no one gets
the points. Whichever group got the points for the last round selects
the category and point value for the next round. If no one got the
question right the last round, the group who selected the previous
question and point value gets to select again.

Double Jeopardy: If a group selects a Double Jeopardy question, they are
the only group allowed to answer. Before the question is asked, they
must decide how many of their points they want to wager -- they can only
wager what they have, nothing more, though of course they can wager
less. Once they decide, the spokesperson will say the wager out loud.
The presenter will then ask the question. The group has 30 seconds to
come up with an answer, which the spokesperson should then say out loud.
If the answer is correct, they receive the number of points wagered. If
incorrect, they lose the number of points wagered. Either way, the group
then selects the next category and point value.

Final Jeopardy: Once all questions have been asked, it is time for the
final Jeopardy question. The presenter picks which final jeopardy
question to be used (only pick one). The students have 15 seconds to
write down how much they want to wager (again, they can only wager what
they have). Each group should write down their group name/number on a
slip of paper and hand that to the presenter. The presenter then asks
the question. The students have 30 seconds to write down an answer and
their group name/number on a different slip of paper. The presenter will
collect the answers and read them individually out loud, along with the
group's wager. If the group gets it right, they get the number of points
wagered added to their score, regardless of what the other groups
answer. If the group gets it wrong, they lose the number of points
wagered. The group with the highest point total at the end of the game
wins.

*Alternative method of play: have the teams write down all of their
answers rather than saying them out loud. The spokesperson raises their
hand only after the group is finished writing their answer. The team is
disqualified if he or she raises their hand before finished writing.*