**David H. Grosof, Ph.D.**

Human Information Processing Research

NASA Ames Reseach Center Mail Stop 262-2

Moffett Field, CA 94035

\(650\) 604-0035 Internet address: grosof@vision.arc.nasa.gov

Born December 8, 1961, in New York City. Citizenship: American

1997-present *National Research Council Senior Research Associate*, NASA
Ames Research Center

With Jeffrey B. Mulligan, projects are:

-   recording eye movements during perceptual and cognitive tasks and
    interpreting them to reveal what is seen and what is remembered,

-   applying advanced image processing to stabilize image sequences of
    retina for improved quantitation of angiographic and eye movement
    experiments.

*Founder and Executive Director* of the Foundation for Vision Science,
an IRS-recognized public charity for the advancement of science. Deploys
Rodenstock scanning laser ophthalmoscope for innovative basic vision and
retinal research.

1993-1997 *Research Assistant Professor of Ophthalmology & Visual
Sciences*, Washington University School of Medicine; Adjunct and
Visiting Research Scientist, Central Institute for the Deaf. Primary
Foci:

-   developing a primate model of retinitis pigmentosa, in which both
    the retinal and CNS effects of a pattern of induced photoreceptor
    damage are examined,

-   improving electroretinographic and perimetric assessment of severely
    impaired retinas,

-   developing a new method of non-invasive imaging of a portion of the
    human retinal nerve fiber layer serving central vision, using a
    scanning laser ophthalmoscope,

> Additional projects:

-   performing advanced retinal imaging and function testing of human
    photoreceptor transplant recipients, and

-   developing *in vivo* imaging of retinal leukocyte dynamics in
    animals.

1989-1993 *Post-doctoral fellow*, New York University, Robert Shapley,
adviser. Main project was a study of the responses of striate neurons to
illusory contours. I also carried out studies of the temporal, chromatic
and spatial properties of striate neurons.

**GRADUATE SCHOOL**

1982-1989 University of California, Berkeley. Received Ph.D.
(Neurobiology) in 1989.

In Russell De Valois\' lab. Performed visual neurophysiology and
psychophysics experiments. Thesis: \"Studies in motion capture\"
examined how motion signals about different spatial scales are combined
in cat striate cortex and by human observers. In collaborations examined
motion psychophysics with Frank Kooi and functional anatomy of macaque
striate cortex with Martin Silverman.

**COLLEGE**

1978-1982 Harvard College, A.B. *cum laude* in Social Studies.
Upper-level courses in vision and neuroscience.

summer 1981 Woods Hole Marine Biological Laboratory intensive summer
course in \"Neural Systems & Behavior\".

**RESEARCH INTERESTS**

Neural substrate for visual performance

Neural plasticity in retina and central visual pathway after peripheral
sensory impairment

Quantitative visual receptive field analysis and non-linear systems
analysis

Retinitis pigmentosa and other retinal degenerations

Color and motion neural modelling

Motion psychophysics

Illusory contour/"Higher order" form psychophysics

Parallel pathways

Scanning laser ophthalmoscopy for visual function testing, fundus
imaging (human and animal)

Functional neuroanatomy

Statistics of spike trains

**GrantS Awarded**

1997-1999 National Research Council Senior Research Associateship.
Project with Jeffrey B. Mulligan at NASA Ames Research Center: "Using
eye movement analysis to evaluate and improve visual performance with
displays"

1997 Created Foundation for Vision Science and obtained funds to
purchase fully equipped Rodenstock scanning laser ophthalmoscope

1996-1998 Juvenile Diabetes Foundation International research grant
"Scanning laser ophthalmoscope imaging of retinal microcirculation in
early diabetes"(\$ 91,700 total; \$ 84,712 TDC)

1996-1997 Jewish Hospital Research Fund "Vision testing in advanced
retinitis pigmentosa" Mitchel Wolf, P.I. (9/96-4/97) *63% T&E*

1993-1997 J. Epstein Foundation grant for vision research (\$100,000
total direct costs)

1992-1993 Special Grant for Exploratory Research, NSF (I wrote 95% of it
but was not P.I.)

1989-1992 National Research Service Award, National Eye Institute (one
of National Insitutes of Health)

1982-1988 NSF Graduate Fellow (3 years) and NIH Training Grant (3 years)

**Grants Pending and Planned**

**BIBLIOGRAPHY**

[PUBLICATIONS]{.underline}

Murphy, M.A., [Grosof]{.smallcaps}, D.H., Hart, W.M., Jr. (1997)
Congenital optic tract syndrome: magnetic resonance imaging and scanning
laser ophthalmoscopy findings. *J. Neuroophthalmology 17*(4): 226-30.

Tezel, T.H., Del Priore, L.V., Flowers, B.E., [Grosof]{.smallcaps},
D.H., Benenson, I.L., Kaplan, H.J. (1996) Correlation between scanning
laser ophthalmoscope microperimetry and anatomic abnormalities in
patients with subfoveal neovascularization. *Ophthalmology 103*(11):
1829-1836.

Hawken, M.J., Shapley, R.M., & [Grosof, D.H.]{.smallcaps} (1996)
Temporal frequency selectivity in monkey visual cortex. *Visual
Neuroscience* *13*(3): 477-492*.*

Ohlemiller, K.K., Hughes, R.M., Speck, J.D., Mosinger-Ogilvie, J.,
[Grosof]{.smallcaps}, D.H., and Silverman, M.S. (1995) Cochlear and
retinal degeneration in the *tubby* mouse. *NeuroReport 6*: 85-89.

[Grosof, D.H.]{.smallcaps} & Lakshminarayan, V. (1995) Scanning laser
ophthalmoscope imaging of the papillomacular bundle of the nerve fiber
layer, in *Vision Science and its Applications*, 1995 Technical Digest
Series, Vol. 3 (Optical Society of America, Washington, DC, 1995) ),
134-137.

Skottun, B.C., Zhang, J. & [Grosof, D.H.]{.smallcaps} (1994) On the
directional selectivity of cells in the visual cortex to drifting dot
patterns. *Visual Neuroscience 11:* 885-897.

[Grosof, D.H.]{.smallcaps}, Shapley, R.M., & Hawken, M.J. (1993) Macaque
V1 neurons signal \"illusory\" contours. *Nature 365:* 550-552.

Kooi, F.L., De Valois, K.K., [Grosof, D.H.]{.smallcaps} & De Valois,
R.L. (1992) Properties of the recombination of one-dimensional motion
signals into a pattern motion signal. *Perception & Psychophysics*
*52*(4): 415-424.

Kooi, F.L., De Valois, K.K., Switkes, E. & [Grosof, D.H.]{.smallcaps}
(1992) Higher order factors influencing the perception of sliding and
coherence of a plaid. *Perception* *21*(5): 583-598.

Skottun, B.C., De Valois, R.L., [Grosof, D.H.]{.smallcaps}, Movshon,
J.A., Albrecht, D.G. and Bonds, A.B. (1991) Classifying simple and
complex cells on the basis of response modulation. *Vision Research 31*:
1079-1086.

Silverman, M.S., [Grosof, D.H.]{.smallcaps}, De Valois, R.L. & Elfar,
S.E. (1989) Spatial frequency organization in primate striate cortex.
*Proc. Natl. Acad. Sci. USA 86*: 711-715.

Skottun, B.C., [Grosof, D.H.]{.smallcaps} and De Valois, R.L. (1988)
Responses of simple and complex cells to random dot patterns: A
quantitative comparison. *J. Neurophysiol. 59*(6): 1719-1735.

[Abstracts]{.underline}

Hart abstract to perimetric society; diabetes; arvo 97;neuroscience 1997

[Grosof]{.smallcaps}, D.H., Mulligan, J.B. & Gidday, J.M. (1998)
Improved estimates of CNS blood flow by image registration of
angiographic videos. *Soc. Neurosci. Abstr. 24: 429*.

Gidday, J.M., Schneider, A.N., Shah, A.R., Benenson, I.L., Gonzales,
E.R., Zhu, Y., Park, T.S., Grosof, D.H. (1998) Leukocytes in the early
diabetic rat retina resolved by scanning laser ophthalmscopy (SLO).
Presented at 58th Annual Meeting of the American Diabetes Association,
Chicago, IL, June 13-16, 1998.

[Grosof, D.H.,]{.smallcaps} Benenson, I.L, Mulligan, J.B., & Gidday,
J.M. (1998) Optimizing Scanning Laser Ophthalmoscope (SLO) imaging of
rodent eyes. *Suppl. Invest. Ophthalmol. Vis. Sci.* *39:* S589..

[Grosof]{.smallcaps}, D.H. & Wolf, M.L. (1997) A new approach for
reliable ERG measurement in advanced retinitis pigmentosa. *Suppl.
Invest. Ophthalmol. Vis. Sci.* *38:* S878.

Gidday, J.M., Maceren, R.G., Meier, J.A., Shah, A.R.,
[Grosof,]{.smallcaps} D.H., Zhu, Y. (1997) Adherent leukocytes mediate
postasphyxic hypoperfusion in piglets. *Suppl. Invest. Ophthalmol. Vis.
Sci.* *38:* S102.

Kaplan, H.J., Tezel, T., Wolf, M.L., [Grosof, D.H]{.smallcaps}., Berger,
A.S., Del Priore, L.V. (1996) Photoreceptor transplantation in retinitis
pigmentosa. 1996 Macula Society meeting.

Tezel, T.H., [Grosof, D.H.,]{.smallcaps} Del Priore, L.V., Kaplan, H.J.
(1996) Human photoreceptor transplantation in the non-human primate
(NHP). *Suppl. Invest. Ophthalmol. Vis. Sci.* *36:* S96.

[Grosof]{.smallcaps}, D.H, Ohlemiller, K.K., Falsini, B.,
Mosinger-Ogilvie, J., M.S. Silverman (1995) A non-human primate model of
retinitis pigmentosa. *Soc. Neurosci. Abstr. 21: 1647*.

Tezel, T.H., Flowers, B.E., Del Priore, L.V., [Grosof]{.smallcaps},
D.H., Benenson, I, Kaplan, H.J. (1995) Correlation between SLO
microperimetry and anatomic findings in patients with subfoveal
neovascular membranes (SFNVM). Presented at annual meeting of American
Academy of Ophthalmology, 1995.

Wolf, M.L. & [Grosof]{.smallcaps}, D.H. (1995) Modified \"Focal\"
Electroretinography: A new approach for reliably measuring cone function
in advanced retinitis pigmentosa. Presented at ISCEV 33rd Symposium,
June, 1995, Athens, Greece.

[Grosof]{.smallcaps}, D.H., Murphy, M.A., Hart, W.M., Jr., &
Lakshminarayanan, V. (1995) Scanning laser ophthalmoscope imaging of the
papillomacular bundle of the nerve fiber layer. *Suppl. Invest.
Ophthalmol. Vis. Sci.* *36:* S675

Soltau, J.B., [Grosof, D.H.]{.smallcaps}, Del Priore, L.V., Benenson, I.
& Kaplan, H.J. (1995) Delayed recovery of vision in age-related macular
degeneration (AMD) associated with RPE hyperplasia. *Suppl. Invest.
Ophthalmol. Vis. Sci.* *36:* . S234.

Ohlemiller, K.K., Hughes, R.M., Speck, J., Ogilvie, J.M.,
[Grosof]{.smallcaps}., D.H., and Silverman, M.S. (1995) Cochlear
Anomalies in a Candidate Mouse Model of Usher\'s Syndrome. *Abstr.
Midwinter Meeting Ass. Res. Otolaryngol.* *18*: 87.

[Grosof, D.H.]{.smallcaps}, Falsini, B., Rastelli, A.L., Heidbreder, A.,
Meyer, D.J., Ohlemiller, K.K. and Silverman, M.S. (1994) Focal ERG in
rabbit: dependence on stimulus eccentricity and area. *Suppl. Invest.
Ophthalmol. Vis. Sci.* *35*: 2044.

Falsini, B., [Grosof, D.H.]{.smallcaps}, Rastelli, A.L. and Silverman,
M.S. (1994) A non-human primate model for retinitis pigmentosa: ERG
evidence. *Suppl. Invest. Ophthalmol. Vis. Sci. 35*: 2047.

Hawken, M.J., Shapley, R., Gordon, J., [Grosof, D.H.]{.smallcaps}, and
Mechler, F. (1994) Comparison of temporal tuning in primate geniculate
and V1. *Suppl. Invest. Ophthalmol. Vis. Sci. 35*: 1662.

Hawken, M.J., Shapley, R.M. and [Grosof, D.H.]{.smallcaps} (1993)
Organization of chromatic inputs to direction selective neurons in
macaque V1. *Suppl. Invest.* *Ophthalmol. Vis. Sci. 34*: 793.

[Grosof, D.H.]{.smallcaps}, Shapley, R.M. and Hawken, M.J. (1992) Monkey
striate responses to anamalous contours? *Suppl. Invest. Ophthalmol.
Vis. Sci. 33*: 1257.

Hawken, M.J., Shapley, R.M. and [Grosof, D.H.]{.smallcaps} (1992)
Temporal frequency tuning of neurons on macaque V1: effects of luminance
contrast and chromaticity. *Suppl. Invest. Ophthalmol. Vis. Sci. 33*:
955.

Shapley, R.M., Hawken, M.J. and [Grosof, D.H.]{.smallcaps} (1992)
Macaque V1 and color: single cell responses to cone-isolating stimuli.
*Suppl. Invest. Ophthalmol. Vis. Sci. 33*: 1021.

[Grosof, D.H.]{.smallcaps}, Shapley, R.M. and Hawken, M.J. (1991)
Anomalous responses in V1 to anomalous contours? *Soc. Neurosci. Abstr.
17*: 177.

Hawken, M.J., Shapley, R.M. and [Grosof, D.H.]{.smallcaps} (1991)
Characteristics of temporal frequency tuning of neurons in macaque V1.
*Soc. Neurosci. Abstr. 17*: 177.

[Grosof, D.H.]{.smallcaps} and De Valois, R.L. (1990) The striate cortex
and multi-scale motion processing. *Suppl. Invest. Ophthalmol. Vis. Sci.
31*: 239.

[Grosof, D.H.]{.smallcaps} (1989) Isoluminanant motion and pattern
vision without zero-crossings. *Suppl. Invest.* *Ophthalmol. Vis. Sci.
30*: 110.

Kooi, F.L., De Valois, K.K., [Grosof, D.H.]{.smallcaps} and Switkes, E.
(1989) Coherence properties of colored moving plaids. *Suppl. Invest.
Ophthalmol. Vis. Sci. 30*(3): 389.

Kooi, F.L., [Grosof, D.H.]{.smallcaps}, De Valois, R.L. & De Valois,
K.K. (1988) Spatial frequency affects perceived direction of a moving
plaid, in *OSA Annual Meeting, Technical Digest Series, Vol. 11*
(Optical Society of America, Washington, D.C., 1988), 163.

[Grosof, D.H.]{.smallcaps}, Silverman, M.S., De Valois, R.L. and Elfar,
S.E. (1988) Spatial frequency organization of primate striate cortex.
*Soc. Neurosci. Abstr. 14*: 898.

[Grosof, D.H.]{.smallcaps} and De Valois, R.L. (1987) Do low frequencies
disproportionately determine the direction of movement of periodic
patterns? *Suppl. Invest. Ophthalmol. Vis. Sci. 28*(3): 298.

Skottun, B.C., [Grosof, D.H.]{.smallcaps} and De Valois, R.L. (1985)
Responses of simple and complex cells in the cat visual cortex to visual
dot stimuli. *Soc. Neurosci. Abstr. 11*: 265.

[Grosof, D.H.]{.smallcaps}, Skottun, B.C. and De Valois, R.L. (1985)
Linearity of cat cortical cells: responses to 2-D stimuli. *Suppl.
Invest. Ophthalmol. Vis. Sci. 26*(3):265.

[Manuscripts submitted or in preparation]{.underline}

[Grosof, D.H. &]{.smallcaps} Mulligan, J.B. (in preparation) Improved
estimates of retinal blood flow by image registration of angiographic
image sequences.

[Grosof, D.H.,]{.smallcaps} Falsini, B., Ohlemiller, K.K., & Silverman,
M.S. (in preparation) A non-human primate model of retinitis pigmentosa:
funduscopic and ERG evidence.

[Grosof, D.H.,]{.smallcaps} Mosinger Ogilvie, J., Ohlemilller, K.K. &
Silverman, M.S. (in preparation) A non-human primate model of retinitis
pigmentosa: histologic evidence.

[Grosof]{.smallcaps}, D.H., Murphy, M.A., Hart, W.M., Jr., &
Lakshminarayanan, V. (in preparation) Scanning laser ophthalmoscope
imaging of the papillomacular bundle of the nerve fiber layer.

Murphy, M.A., [Grosof]{.smallcaps}, D.H., Hart, W.M., Jr. (submitted)
Optic neuritis: photo essay.

Wolf, M.L. & [Grosof]{.smallcaps}, D.H. (in preparation) Modified
\"Focal\" Electroretinography: A new approach for reliably measuring
cone function in advanced retinitis pigmentosa.

[Grosof, D.H.]{.smallcaps}, Shapley, R.M., & Hawken, M.J. (in
preparation) Macaque V1 neurons signalling of \"illusory\" contours.

[Grosof, D.H.]{.smallcaps} & De Valois, R.L. (in preparation) Low
spatial frequencies are disproportionately important in perception of
direction. I. Psychophysics.

[Grosof, D.H.]{.smallcaps} & De Valois, R.L. (in preparation) Low
spatial frequencies are disproportionately important in perception of
direction. II. Physiology.

Grosof, D.H (in preparation) Isoluminant motion and pattern vision
without zero-crossings.

other manuscripts include son of checkerboard, a third motion paper, and
Miramonti perimetry paper

**Unusual Teaching Experience**

New York University, Center for Neural Science, 1990-1 (12 months)
Directed a high school student in visual psychophysics project that won
Semi-Finalist status in the Westinghouse National Science Talent Search.

Washington University, 1995-6. Directed a visually impaired
undergraduate's exploration of the potential of scanning laser
ophthalmoscopy for visual rehabilitation training and clinical testing.

**Teaching Interests**

Neuroscience: general, systems, sensory, behavioral

Clinical Vision: optics, clinical imaging and function testing methods

Perception & Psychophysics

Experimental method and statistics

Neural plasticity

Advanced visual neuroscience

Computational vision & Neural Networks

Linear systems analysis

**Awards and Societies**

Optical Society of America Eastman Foundation Lecturer to the Optical
Society of Chicago, 1997

ARVO Travel Fellowship, 1987

Member of ARVO, 1985-present

Member of Society for Neuroscience, 1989-present

Member of AAAS, 1983-present

Harvard Scholar, 1981-1982