![](media/image1.png){width="2.249212598425197in"
height="2.030708661417323in"}

![](media/image2.png){width="3.2604166666666665in"
height="1.2083333333333333in"}

**NSRL-0 RUN**

**FINAL REPORT**

# Marcelo E. Vazquez

####### Medical Department

**NASA-BNL Liaison Scientist**

**BNL/NASA webpage:**

**http://www.bnl.gov/medical/NASA/NASA-home%20frame.htm**

**August 2003**

**TABLE OF CONTENTS**

Executive Summary 3

NSRL-0 Proposals/SACR Review 4

Participants 5

Participants Statistics 6

Participants Institutions 7

Run Dates/Beam Time Description 8

Statistics 11

Beam Characteristics 15

Run Statistics and Incidents 16

Experimenters and Run Statistics 17

Participants, Experimental Samples and Endpoints 18

List of Personnel 19

####### EXECUTIVE SUMMARY

During the summer of 2003, a series of radiobiological and physics
experiments were performed using the NASA Space Radiation Laboratory to
accelerate iron, carbon and titanium beams (NSRL-0). These experiments
were part of the NSRL commissioning run sponsored by NASA's Space
Radiation Health Program (SRHP) heavy ion radiobiology research program
at BNL.

A total of 12 proposals were approved to participate in the NSRL-0 run.
Seven institutions from the United States and 2 from foreign countries
(Italy and Japan) were represented, totaling 33 users. More than 900
biological samples were exposed at the NSRL beam line, employing 158
hours of beam time (33.5 hours for in vivo studies and 48 hours for in
vitro studies). In addition, 36 hours were used for physics experiments,
and a total of 24.5 hours were necessary for beam characterization,
tuning, dosimetry, and calibration. A total of 16 hours of beam time
were lost (10%) due to accelerator or power supply related problems.

During NSRL-0, AGS provided iron (0.964 GeV/nucleon, LET: 151.5 keV/µm),
Carbon (0.292 GeV/n, LET: 12.9 keV/µm) and Titanium (0.976 GeV/n, LET:
108.2 keV/µm) beams for biology and physics experiments. The dose/rates
used were as low as 1 cGy/min and as high as 2.5 Gy/min. The spill rate
employed was 11 for Fe and Ti and 30 spills/min for C with duration of
400 msec/spill. The spill fluence was (particles/spill) 4 x 10^9^ (max)
and 5 x 10^5^ (min). A 20 x 20 cm square beam spot was employed as a
nominal spot for the majority of the exposures.

Tandem-Booster set-up started on July 5 with the transport and
circulation of Fe beams at the NSRL complex. Beam was tuned into cave on
July 7. 1000 MeV/n Fe beams were available for tuning on July 6. The
next several shifts were spent on beam development (A. Rusek: tuning
into the target area, beam diagnostics and establishing several
different combinations of beam intensities and spot shapes and sizes for
physics and biology studies) and some physics experiments (J. Miller:
beam characterization). Biology studies started on the afternoon of July
8 (M. Vazquez, BNL)) and proceeded through early July 11. On July 14,
AGS tuned 0.29 GeV/n carbon beams for physics studies for 13 hours.
Biology studies started on July 15 (B. Sutherland, BNL) and continued
until July 18. On July 21, AGS complex delivered titanium beams for beam
development and physics. Biology experiments started on July 22 (F.
Cucinotta, JSC) running until early afternoon on July 24. NSRL-0
officially ended at 1330 pm, July 24 2003.

Radiobiological experiments employed cells, tissues, and intact
specimens, which required a complex coordination and planning of their
respective logistic support. Biological studies used human, mouse, rat
and hamster cell lines, human-hamster hybrid cell lines, tumor cell
lines and intact specimens (rodents). The full program was completed in
17 days.

Projects Approved by NASA and BNL's management for the NSRL
Commissioning run (NSRL-0):

+----------+---------------------------+------------------------------+
| **P      | > **P.I.**                | **NSRL-0 Participation**     |
| roject** |                           |                              |
+----------+---------------------------+------------------------------+
| **N-9**  | > **Gewirtz/Sutherland**  | **Yes**                      |
+----------+---------------------------+------------------------------+
| **N-19** | > **Kronenberg**          | **Yes**                      |
+----------+---------------------------+------------------------------+
| **N-73** | > **Sutherland**          | **Yes**                      |
+----------+---------------------------+------------------------------+
| **N-76** | > **Green**               | **Yes**                      |
+----------+---------------------------+------------------------------+
| **N-77** | > **Nelson**              | **Yes**                      |
+----------+---------------------------+------------------------------+
| **N-78** | > **Nelson**              | **Yes**                      |
+----------+---------------------------+------------------------------+
| **N-79** | > **Pecaut**              | **Yes**                      |
+----------+---------------------------+------------------------------+
| **N-80** | > **Gonda**               | **Yes**                      |
+----------+---------------------------+------------------------------+
| **N-81** | > **Vazquez**             | **Yes**                      |
+----------+---------------------------+------------------------------+
| **N-82** | **Obenaus**               | **Yes**                      |
+----------+---------------------------+------------------------------+
| **N-83** | > **Obenaus**             | **Yes**                      |
+----------+---------------------------+------------------------------+
| **N-84** | > **Cucinotta**           | **Yes**                      |
+----------+---------------------------+------------------------------+

**[NSRL-0 PARTICIPANTS]{.underline}**

+----+--------------+-----------------------------+-------------------+
| ** | **Pa         | **Affiliation**             | **Title**         |
| Ex | rticipants** |                             |                   |
| p. |              |                             |                   |
| ** |              |                             |                   |
+----+--------------+-----------------------------+-------------------+
| N  | A.           | University of Pennsylvania, | Ph.D., Principal  |
| -9 | Gerwirtz\*   | Dept. of Medicine           | Investigator      |
|    |              |                             |                   |
|    | B.           | Brookhaven National         | Ph.D.,            |
|    | Sutherland   | Laboratory                  | Co-Principal      |
|    |              |                             | Invest.           |
|    | P. Bennett   | \"                          |                   |
|    |              |                             | MS., Biology      |
|    | A.           | \"                          | Associate         |
|    | Georgakilas  |                             |                   |
|    |              | \"                          | Ph.D., Co-Worker  |
|    | M. Hada      |                             |                   |
|    |              | "                           | Ph.D., Co-Worker  |
|    | S. Paul      |                             |                   |
|    |              | "                           | Ph.D., Co-Worker  |
|    | J.           |                             |                   |
|    | Sutherland   | "                           | Ph.D., Co-Worker  |
|    |              |                             |                   |
|    | D.           | "                           | Co-Worker         |
|    | Monteleone   |                             |                   |
|    |              |                             | Co-Worker         |
|    | J. Trunk     |                             |                   |
+----+--------------+-----------------------------+-------------------+
| N- | A.           | Lawrence Berkeley National  | Ph.D., Principal  |
| 19 | Kronenberg   | Lab                         | Investigator      |
+----+--------------+-----------------------------+-------------------+
| N- | B.           | Brookhaven National         | Ph.D., Principal  |
| 73 | Sutherland   | Laboratory                  | Investigator      |
|    |              |                             |                   |
|    | P. Bennett   | \"                          | MS., Biology      |
|    |              |                             | Associate         |
|    | A.           | \"                          |                   |
|    | Georgakilas  |                             | Ph.D., Co-Worker  |
|    |              | \"                          |                   |
|    | M. Hada      |                             | Ph.D., Co-Worker  |
|    |              | "                           |                   |
|    | S. Paul      |                             | Ph.D., Co-Worker  |
|    |              | "                           |                   |
|    | J.           |                             | Ph.D., Co-Worker  |
|    | Sutherland   | "                           |                   |
|    |              |                             | Co-Worker         |
|    | D.           | "                           |                   |
|    | Monteleone   |                             | Co-Worker         |
|    |              |                             |                   |
|    | J. Trunk     |                             |                   |
+----+--------------+-----------------------------+-------------------+
| N- | L. Green     | Loma Linda University, CA   | Ph.D., Principal  |
| 76 |              |                             | Investigator      |
|    | B. Bianski   | "                           |                   |
|    |              |                             | Co-Worker         |
+----+--------------+-----------------------------+-------------------+
| N- | G. Nelson    | Loma Linda University, CA   | Ph.D., Principal  |
| 77 |              |                             | Investigator      |
|    | A.  Smith    | \"                          |                   |
| N- |              |                             | BS, Co-Worker     |
| 78 | T. Jones     | "                           |                   |
|    |              |                             | BS, Co-Worker     |
+----+--------------+-----------------------------+-------------------+
| N- | M. Pecaut    | Loma Linda University, CA   | Ph.D., Principal  |
| 79 |              |                             | Investigator      |
|    | G. Nelson    | \"                          |                   |
|    |              |                             | Ph.D.,            |
|    | A.  Smith    | "                           | Co-Principal      |
|    |              |                             | Invest.           |
|    | S. Rightnar  | "                           |                   |
|    |              |                             | BS, Co-Worker     |
|    | T. Jones     | "                           |                   |
|    |              |                             | BS, Co-Worker     |
|    |              |                             |                   |
|    |              |                             | BS, Co-Worker     |
+----+--------------+-----------------------------+-------------------+
| N- | S. Gonda     | NASA, Johnson Space Center, | Ph.D., Principal  |
| 80 |              | TX                          | Investigator      |
|    | E. Behravesh |                             |                   |
|    |              | "                           | Ph.D., Co-Worker  |
+----+--------------+-----------------------------+-------------------+
| N- | M. Vazquez   | Brookhaven National         | MD, Ph.D.,        |
| 81 |              | Laboratory                  | Principal Invest. |
|    | P. Guida     |                             |                   |
|    |              | "                           | Ph.D., Co-Worker  |
|    | K. Nojima    |                             |                   |
|    |              | "                           | Ph.D., Co-Worker  |
|    | S. Otto      |                             |                   |
|    |              | "                           | BS, Co-Worker     |
|    | M. Bruneus   |                             |                   |
|    |              | "                           | MA, Co-Worker     |
|    | A. Billups   |                             |                   |
|    |              | "                           | BA, Co-Worker     |
|    | S. Russell   |                             |                   |
|    |              | "                           | BS, Co-Worker     |
+----+--------------+-----------------------------+-------------------+
| N- | A. Obenaus   | Loma Linda University, CA   | Ph.D., Principal  |
| 82 |              |                             | Investigator      |
|    |              |                             |                   |
| N- |              |                             |                   |
| 83 |              |                             |                   |
+----+--------------+-----------------------------+-------------------+
| N- | F. Cucinotta | NASA, Johnson Space Center, | Ph.D., Principal  |
| 84 |              | TX                          | Investigator      |
|    | K. George    |                             |                   |
|    |              | "                           | Senior Research   |
|    | P. O'Neill   |                             | Associate         |
|    |              | "                           |                   |
|    | E. Davis     |                             | Ph.D.,            |
|    |              | "                           | Co-Principal      |
|    | H. Wu        |                             | Invest.           |
|    |              | "                           |                   |
|    | N. Desai     |                             | Ph.D., Co-Worker  |
|    |              | "                           |                   |
|    | M. Durante   |                             | Ph.D., Co-Worker  |
|    |              | University "Federico II",   |                   |
|    |              | Napoli, Italy               | BS, Co-Worker     |
|    |              |                             |                   |
|    |              |                             | Ph.D., Co-Worker  |
+----+--------------+-----------------------------+-------------------+

**\*Not Present During Actual Run**

[**NSRL-0** **PARTICIPANTS STATISTICS**]{.underline}

![](media/image3.wmf)

**[RESEARCH PROJECT SPONSORS:]{.underline}**

**[Participant Institutions]{.underline}**

**[NASA related centers/institutes]{.underline} (3)**

-   **NASA, Headquarters, DC**

-   **NASA, Johnson Space Center, TX**

-   **National Space Biomedical Research Institute, TX**

**[National Laboratories/Institutes]{.underline} (2)**

-   **Brookhaven National Laboratory, NY**

-   **Lawrence Berkeley National Laboratory, CA**

**[Universities]{.underline} (2)**

-   **Loma Linda University, CA**

-   **University of Pennsylvania, PA**

**[Foreign Institutions]{.underline} (2)**

-   **University "Federico II", Napoli, Italy**

-   **International Space Radiation Laboratory, Chiba, Japan**

![](media/image4.wmf)**INSTITUTIONS STATISTICS:**

# 

**[NSRL-0 IRON RUN DESCRIPTION]{.underline}**

# RUN DATES

  ----------------------------------- --------------- ---------- ------------ ----------
  **Run dates**                       **Scheduled**              **Actual**   

                                      **Date**        **Time**   **Date**     **Time**

  **Run start**                       **07/07**       **0700**   **07/07**    **0700**

  **Run end**                         **07/11**       **1900**   **07/11**    **2000**

                                                                              

  **Tuned into cave**                 **07/07**       **0700**   **07/07**    **1200**

                                                                              

  **Beam delivered for Physics**                                              

  **Fe 1 GeV/n**                      **07/07**       **0900**   **07/07**    **1400**

  **End run**                         **07/08**       **1300**   **07/08**    **1230**

  **Beam delivered for Biology**                                              

  **Fe 1 GeV/n**                      **07/08**       **1300**   **07/08**    **1500**

  **End run**                         **07/11**       **1900**   **07/11**    **2000**
  ----------------------------------- --------------- ---------- ------------ ----------

**Beam Time Description (hours)**

+-------------------------+------------------+---------------+--------+
| **Total Clock Time**    | **(from 07/07    |               | **     |
|                         | 0700 to 07/11    |               | 62.5** |
|                         | 2000)**          |               |        |
+-------------------------+------------------+---------------+--------+
|                         |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Total Beam-on time**  |                  |               | **     |
|                         |                  |               | 56.5** |
+-------------------------+------------------+---------------+--------+
|                         |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Total Beam-off time** |                  |               | **6**  |
+-------------------------+------------------+---------------+--------+
|                         |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Beam Time for         |                  |               |        |
| Biology**               |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Fe 1 GeV/n In Vitro   | **20**           |               |        |
| Studies**               |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Fe 1 GeV/n In Vivo    | **12.5**         |               |        |
| Studies**               |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Sub-total**           |                  | **32.5**      |        |
+-------------------------+------------------+---------------+--------+
|                         |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Beam Time for         |                  |               |        |
| Physics**               |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Fe 1 GeV/n**          | **10**           |               |        |
+-------------------------+------------------+---------------+--------+
| **Sub-total**           |                  | **10**        |        |
+-------------------------+------------------+---------------+--------+
|                         |                  |               |        |
+-------------------------+------------------+---------------+--------+
| > **Beam time for       |                  |               |        |
| > dosimetry,            |                  |               |        |
| > calibration, tuning,  |                  |               |        |
| > etc.**                |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Fe 1 GeV/n**          | **4**            |               |        |
+-------------------------+------------------+---------------+--------+
| **Sub-total**           |                  | **4**         |        |
+-------------------------+------------------+---------------+--------+
| > **Set Up Time**       |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Fe 1 GeV/n**          | **10**           |               |        |
+-------------------------+------------------+---------------+--------+
| **Sub-total**           |                  | **10**        |        |
+-------------------------+------------------+---------------+--------+
| **Totals**              |                  | **56.5**      |        |
+-------------------------+------------------+---------------+--------+
|                         |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Contingency T.        | **12.5**         |               |        |
| Planned**               |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Contingency T. Used** | **8**            |               |        |
+-------------------------+------------------+---------------+--------+

# [NSRL-0 CARBON RUN DESCRIPTION]{.underline}

# RUN DATES

  ----------------------------------- --------------- ---------- ------------ ----------
  **Run dates**                       **Scheduled**              **Actual**   

                                      **Date**        **Time**   **Date**     **Time**

  **Run start**                       **07/14**       **0700**   **07/14**    **0700**

  **Run end**                         **07/18**       **1800**   **07/18**    **1330**

                                                                              

  **Tuned into cave**                 **07/14**       **0700**   **07/14**    **0815**

                                                                              

  **Beam delivered for Physics**                                              

  **C 0.29 GeV/n**                    **07/14**       **0900**   **07/14**    **1200**

  **End run**                         **07/15**       **1300**   **07/15**    **1400**

  **Beam delivered for Biology**                                              

  **C 0.29 GeV/n**                    **07/15**       **1300**   **07/15**    **1400**

  **End run**                         **07/18**       **1800**   **07/18**    **1330**
  ----------------------------------- --------------- ---------- ------------ ----------

**Beam Time Description (hours)**

+-------------------------+------------------+---------------+--------+
| **Total Clock Time**    | **(from 07/14    |               | **     |
|                         | 0700 to 07/18    |               | 52.5** |
|                         | 1330)**          |               |        |
+-------------------------+------------------+---------------+--------+
|                         |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Total Beam-on time**  |                  |               | **50** |
+-------------------------+------------------+---------------+--------+
|                         |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Total Beam-off time** |                  |               | *      |
|                         |                  |               | *2.5** |
+-------------------------+------------------+---------------+--------+
|                         |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Beam Time for         |                  |               |        |
| Biology**               |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **In Vitro Studies**    | **13**           |               |        |
+-------------------------+------------------+---------------+--------+
| **In Vivo Studies**     | **11**           |               |        |
+-------------------------+------------------+---------------+--------+
| **Sub-total**           |                  | **24**        |        |
+-------------------------+------------------+---------------+--------+
|                         |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Beam Time for         |                  |               |        |
| Physics**               |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **C 0.29 GeV/n**        | **13**           |               |        |
+-------------------------+------------------+---------------+--------+
| **Sub-total**           |                  | **13**        |        |
+-------------------------+------------------+---------------+--------+
|                         |                  |               |        |
+-------------------------+------------------+---------------+--------+
| > **Beam time for       |                  |               |        |
| > dosimetry,            |                  |               |        |
| > calibration, tuning,  |                  |               |        |
| > etc.**                |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **C 0.29 GeV/n**        | **0**            |               |        |
+-------------------------+------------------+---------------+--------+
| **Sub-total**           |                  | **0**         |        |
+-------------------------+------------------+---------------+--------+
| > **Set Up Time**       |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **C 0.29 GeV/n**        | **13**           |               |        |
+-------------------------+------------------+---------------+--------+
| **Sub-total**           |                  | **13**        |        |
+-------------------------+------------------+---------------+--------+
|                         |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Contingency T.        | **8**            |               |        |
| Planned**               |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Contingency T. Used** | **6**            |               |        |
+-------------------------+------------------+---------------+--------+
|                         |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Totals**              |                  | **56.5**      |        |
+-------------------------+------------------+---------------+--------+

# [NSRL-0 TITANIUM RUN DESCRIPTION]{.underline}

# RUN DATES

  ----------------------------------- --------------- ---------- ------------ ----------
  **Run dates**                       **Scheduled**              **Actual**   

                                      **Date**        **Time**   **Date**     **Time**

  **Run start**                       **07/21**       **0700**   **07/21**    **0700**

  **Run end**                         **07/24**       **1800**   **07/24**    **1330**

                                                                              

  **Tuned into cave**                 **07/21**       **0700**   **07/21**    **0815**

                                                                              

  **Beam delivered for Physics**                                              

  **Ti 1 GeV/n**                      **07/21**       **0900**   **07/21**    **0900**

  **End run**                         **07/22**       **1300**   **07/22**    **1100**

  **Beam delivered for Biology**                                              

  **Ti 1 GeV/n**                      **07/22**       **0900**   **07/22**    **1600**

  **End run**                         **07/24**       **1800**   **07/24**    **1330**
  ----------------------------------- --------------- ---------- ------------ ----------

**Beam Time Description (hours)**

+-------------------------+------------------+---------------+--------+
| **Total Clock Time**    | **(from 07/21    |               | **43** |
|                         | 0700 to 07/24    |               |        |
|                         | 1330)**          |               |        |
+-------------------------+------------------+---------------+--------+
|                         |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Total Beam-on time**  |                  |               | **     |
|                         |                  |               | 35.5** |
+-------------------------+------------------+---------------+--------+
|                         |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Total Beam-off time** |                  |               | *      |
|                         |                  |               | *7.5** |
+-------------------------+------------------+---------------+--------+
|                         |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Beam Time for         |                  |               |        |
| Biology**               |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **In Vitro Studies**    | **15**           |               |        |
+-------------------------+------------------+---------------+--------+
| **In Vivo Studies**     | **0**            |               |        |
+-------------------------+------------------+---------------+--------+
| **Sub-total**           |                  | **15**        |        |
+-------------------------+------------------+---------------+--------+
|                         |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Beam Time for         |                  |               |        |
| Physics**               |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Ti 1 GeV/n**          | **13**           |               |        |
+-------------------------+------------------+---------------+--------+
| **Sub-total**           |                  | **13**        |        |
+-------------------------+------------------+---------------+--------+
|                         |                  |               |        |
+-------------------------+------------------+---------------+--------+
| > **Beam time for       |                  |               |        |
| > dosimetry,            |                  |               |        |
| > calibration, tuning,  |                  |               |        |
| > etc.**                |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Ti 1 GeV/n**          | **0**            |               |        |
+-------------------------+------------------+---------------+--------+
| **Sub-total**           |                  | **0**         |        |
+-------------------------+------------------+---------------+--------+
| > **Set Up Time**       |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Ti 1 GeV/n**          | **7.5**          |               |        |
+-------------------------+------------------+---------------+--------+
| **Sub-total**           |                  | **7.5**       |        |
+-------------------------+------------------+---------------+--------+
|                         |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Contingency T.        | **6.5**          |               |        |
| Planned**               |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Contingency T. Used** | **4.5**          |               |        |
+-------------------------+------------------+---------------+--------+
|                         |                  |               |        |
+-------------------------+------------------+---------------+--------+
| **Totals**              |                  | **35.5**      |        |
+-------------------------+------------------+---------------+--------+

NSRL-0 FINAL RUN DATES

  ----------------------------------- --------------- ---------- ------------ ----------
  **Run dates**                       **Scheduled**              **Actual**   

                                      **Date**        **Time**   **Date**     **Time**

  **Run start**                       **07/07**       **0700**   **07/07**    **0700**

  **Run end**                         **07/24**       **1800**   **07/24**    **1330**

                                                                              

  **Tuned into cave**                 **07/07**       **0700**   **07/07**    **1200**

                                                                              
  ----------------------------------- --------------- ---------- ------------ ----------

**[total Beam Time Description (hours)]{.underline}**

+--------------------------+----------------+---------------+--------+
| **Total Clock Time**     | **(from07/07   |               | *      |
|                          | 0700 to 07/24  |               | *158** |
|                          | 1330)**        |               |        |
+--------------------------+----------------+---------------+--------+
|                          |                |               |        |
+--------------------------+----------------+---------------+--------+
| **Total Beam-on Time**   |                |               |        |
+--------------------------+----------------+---------------+--------+
| **Fe 1 GeV/n**           | **56.5**       |               |        |
+--------------------------+----------------+---------------+--------+
| **C 0.29 GeV/n**         | **50.0**       |               |        |
+--------------------------+----------------+---------------+--------+
| **Ti 1 GeV/n**           | **35.5**       |               |        |
+--------------------------+----------------+---------------+--------+
| **Total**                |                | **142**       |        |
+--------------------------+----------------+---------------+--------+
|                          |                |               |        |
+--------------------------+----------------+---------------+--------+
| **Total Beam-off time**  |                |               |        |
+--------------------------+----------------+---------------+--------+
| **Fe 1 GeV/n**           | **6**          |               |        |
+--------------------------+----------------+---------------+--------+
| **C 0.29 GeV/n**         | **2.5**        |               |        |
+--------------------------+----------------+---------------+--------+
| **Ti 1 GeV/n**           | **7.5**        |               |        |
+--------------------------+----------------+---------------+--------+
| **Total**                |                | **16**        |        |
+--------------------------+----------------+---------------+--------+
|                          |                |               |        |
+--------------------------+----------------+---------------+--------+
| **Total Beam Time for    |                |               |        |
| Biology**                |                |               |        |
+--------------------------+----------------+---------------+--------+
| **In Vivo Studies**      | **33.5**       |               |        |
+--------------------------+----------------+---------------+--------+
| **In Vitro Studies**     | **48**         |               |        |
+--------------------------+----------------+---------------+--------+
| **Total**                |                | **81.5**      |        |
+--------------------------+----------------+---------------+--------+
|                          |                |               |        |
+--------------------------+----------------+---------------+--------+
| **Beam Time for          | **36**         |               |        |
| Physics**                |                |               |        |
+--------------------------+----------------+---------------+--------+
| **Total**                |                | **36**        |        |
+--------------------------+----------------+---------------+--------+
|                          |                |               |        |
+--------------------------+----------------+---------------+--------+
| > **Beam time for        | **4**          |               |        |
| > dosimetry,             |                |               |        |
| > calibration, tuning,   |                |               |        |
| > etc.**                 |                |               |        |
+--------------------------+----------------+---------------+--------+
| **Total**                |                | **4**         |        |
+--------------------------+----------------+---------------+--------+
|                          |                |               |        |
+--------------------------+----------------+---------------+--------+
| > **Set Up Time**        | **20.5**       |               |        |
+--------------------------+----------------+---------------+--------+
| **Total**                |                | **20.5**      |        |
+--------------------------+----------------+---------------+--------+
|                          |                |               |        |
+--------------------------+----------------+---------------+--------+
| **Contingency T.         | **27**         |               |        |
| Planned**                |                |               |        |
+--------------------------+----------------+---------------+--------+
| **Contingency T. Used**  | **8.5**        |               |        |
+--------------------------+----------------+---------------+--------+
|                          |                |               |        |
+--------------------------+----------------+---------------+--------+
| **Totals**               |                | **142**       | *      |
|                          |                |               | *158** |
+--------------------------+----------------+---------------+--------+

![](media/image5.wmf)**[Descriptive statistics]{.underline}**

-   **fe 1 GeV/n Beam Availability**

![](media/image6.wmf)

-   **C 290 MeV/n Beam Availability**

> ![](media/image7.wmf)
>
> **Ti 1 GeV/n Beam Availability**
>
> ![](media/image8.wmf)
>
> **IRON ION RUN:**

-   **Fe 1 GeV/n Distribution of Beam Time Usage:**

![](media/image9.wmf)

-   **Fe 1 GeV/n Distribution of Beam Time for Biology:**

# 

# 

# ![](media/image10.wmf)

> **CARBON ION RUN**

# C 0.29 GeV/n Distribution of Beam Time Usage:

# 

# 

# 

# 

# 

# ![](media/image11.wmf)

# 

# 

# 

# C 0.29 GeV/n Distribution of Beam Time for Biology:

# 

# 

# 

# 

# 

# 

# ![](media/image10.wmf)

# 

# TITANIUM ION RUN

-   **Si 1 GeV/n Distribution of Beam Time Usage:**

-   **Ti 1 GeV/n Distribution of Beam Time for Biology:**

# ![](media/image12.wmf)

# 

# 

# 

# 

# 

# 

# 

# 

# [NSRL-0 TOTAL BEAM TIME SUMMARY]{.underline}

![](media/image13.wmf)

# DISTRIBUTION OF BEAM TEAM USAGE:

![](media/image14.wmf)

# DISTRIBUTION OF BEAM TEAM BY SPECIES AND ENERGIES:

![](media/image15.wmf)

# DISTRIBUTION OF BEAM TEAM FOR BIOLOGY EXPERIMENTS: 

# [BEAM CHARACTERISTICS]{.underline}

+---------------------------+-------------+-------------+-------------+
| **Ion**                   | **^         | **^         | *           |
|                           | 56^Fe^26^** | 48^Ti^22^** | *^12^C^6^** |
+---------------------------+-------------+-------------+-------------+
| **Fluence                 | **TBD**     | **TBD**     | **TBD**     |
| (particles/cm^2^/sec)**   |             |             |             |
|                           |             |             |             |
| **Maximum on target**     |             |             |             |
|                           |             |             |             |
| **Minimum on target**     |             |             |             |
+---------------------------+-------------+-------------+-------------+
| **Spill rate              | **11**      | **11**      | **30**      |
| (spills/min)**            |             |             |             |
+---------------------------+-------------+-------------+-------------+
| **Spill length (msec)**   | **400**     | **400**     | **400**     |
+---------------------------+-------------+-------------+-------------+
| **Particles/spill**       | **1 x       | **3.5 x     | **4.0 x     |
|                           | 10^9^**     | 10^8^**     | 10^9^**     |
| > **Maximum**             |             |             |             |
|                           | **5.0 x     | **5.0 x     | **5.0 x     |
| #### Minimum              | 10^2^**     | 10^2^**     | 10^2^**     |
+---------------------------+-------------+-------------+-------------+
| **Beam Size**             | **25 x 25** | **20 x 20,  | **25 x 25** |
|                           |             | 10 x 10**   |             |
+---------------------------+-------------+-------------+-------------+
| **Beam Cut Off Accuracy** | **\~ 0.5    | **\~ 0.5    | **\~ 0.5    |
|                           | %**         | %**         | %**         |
+---------------------------+-------------+-------------+-------------+
| **Actual Energy (MeV/n)** | ###### 1005 | **1007**    | **300**     |
|                           |             |             |             |
| ##### Extracted           | **964**     | **976**     | **292**     |
|                           |             |             |             |
| > **On Target**           |             |             |             |
+---------------------------+-------------+-------------+-------------+
| **Actual LET on Target    | **151.5**   | **108.2**   | **12.9**    |
| (keV/µm)**                |             |             |             |
+---------------------------+-------------+-------------+-------------+
| **Dose Rate (Gy/min)**    | **3.0**     | **0.5** (20 | **3.0**     |
|                           |             | x 20),      |             |
| **Maximum**               | **0.01**    | **2.5** (10 | **0.01**    |
|                           |             | x 10)       |             |
| **Minimum**               |             |             |             |
|                           |             | ###### 0.01 |             |
+---------------------------+-------------+-------------+-------------+
| **Total Dose (Gy)**       | **5**       | **5**       | **5**       |
|                           |             |             |             |
| **Maximum**               | **0.1**     | **0.1**     | **0.1**     |
|                           |             |             |             |
| **Minimum**               |             |             |             |
+---------------------------+-------------+-------------+-------------+

The "On Target" energies were obtained from Bragg Curve measurements.

The LET reported here is that for the primary ion at the "on target"
energy. Fragmentation was not taken into account. If significant,
fragmentation would result in a lower LET (fragmentation does not appear
to be significant at the target area).

The Dose Rate is measured at the center of the ion-chamber, and does not
necessarily scale with beam size.

> NSRL-0 Run Statistics and Incidents

+--------+----+--------+--------+-------------------------------------+
| **     | *  | **HIP  | *      | **Remarks (CAD 2 shift/day:         |
| Date** | *S | Av     | *Non-H | 7-14/14-21 hr)**                    |
|        | hi | ail.** | IP\*** |                                     |
|        | ft |        |        |                                     |
|        | ** | **(    |        |                                     |
|        |    | set-up |        |                                     |
|        |    | t.)**  |        |                                     |
+========+====+========+========+=====================================+
| **07/0 | *  | > **2  | **5**  | **1 GeV/n Fe run start. Booster     |
| 7/02** | *1 | >      |        | magnet trip.**                      |
|        | ** |  (2)** |        |                                     |
+--------+----+--------+--------+-------------------------------------+
|        | *  | > *    | **0**  | **No incidents.**                   |
|        | *2 | *6.5** |        |                                     |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
| **07/0 | *  | > **7  | **0**  | **No incidents. End Physics Beam    |
| 8/02** | *3 | >      |        | development run**                   |
|        | ** |  (2)** |        |                                     |
+--------+----+--------+--------+-------------------------------------+
|        | *  | > *    | **0**  | **No incidents. Biology run         |
|        | *4 | *6.5** |        | start.**                            |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
| **07/0 | *  | > **7  | **0**  | ## No incidents.                    |
| 9/02** | *5 | >      |        |                                     |
|        | ** |  (2)** |        |                                     |
+--------+----+--------+--------+-------------------------------------+
|        | *  | >      | **1**  | **Gate door security problems**     |
|        | *6 |  **5** |        |                                     |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
| **07/1 | *  | > **7  | **0**  | **No incidents.**                   |
| 0/02** | *7 | >      |        |                                     |
|        | ** |  (2)** |        |                                     |
+--------+----+--------+--------+-------------------------------------+
|        | *  | > *    | **0**  | **No incidents.**                   |
|        | *8 | *3.5** |        |                                     |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
| **07/1 | *  | > **7  | **0**  | **Tandem problems (valves closed),  |
| 1/02** | *9 | >      |        | Vacuum leak at**                    |
|        | ** |  (2)** |        |                                     |
+--------+----+--------+--------+-------------------------------------+
|        | ** | >      | **0**  | **Booster. Vacuum leak at TTB**     |
|        | 10 |  **6** |        |                                     |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
| **07/1 | ** | > **7  | **0**  | **Switch to C 0.29 GeV/n.**         |
| 4/02** | 11 | >      |        |                                     |
|        | ** |  (5)** |        |                                     |
+--------+----+--------+--------+-------------------------------------+
|        | ** | >      | **0**  | **Physics run Beam development**    |
|        | 12 |  **6** |        |                                     |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
| **07/1 | ** | > **7  | **0**  | **Physics run completed**           |
| 5/02** | 13 | >      |        |                                     |
|        | ** |  (2)** |        |                                     |
+--------+----+--------+--------+-------------------------------------+
|        | ** | >      | **0**  | **Biology run start**               |
|        | 14 |  **3** |        |                                     |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
| **07/1 | ** | > **7  | **0**  | **No incidents.**                   |
| 6/02** | 15 | >      |        |                                     |
|        | ** | (16)** |        |                                     |
+--------+----+--------+--------+-------------------------------------+
|        | ** | > *    | **0**  | **No incidents.**                   |
|        | 16 | *4.5** |        |                                     |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
| **07/1 | ** | >      | *      | **Sweep lost.**                     |
| 7/02** | 17 |  **6.5 | *0.5** |                                     |
|        | ** | >      |        |                                     |
|        |    |  (2)** |        |                                     |
+--------+----+--------+--------+-------------------------------------+
|        | ** | >      | **0**  | **No incidents.**                   |
|        | 18 |  **4** |        |                                     |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
| **07/1 | ** | >      | **2**  | **False fire alarm**                |
| 8/02** | 19 |  **4.5 |        |                                     |
|        | ** | >      |        |                                     |
|        |    |  (2)** |        |                                     |
+--------+----+--------+--------+-------------------------------------+
|        | ** |        |        | **CAD beam development (Adam        |
|        | 20 |        |        | Rusek)**                            |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
| **07/2 | ** | > **7  | **0**  | **Switch to Ti 1 GeV/n. Physics run |
| 1/02** | 21 | >      |        | start.**                            |
|        | ** |  (2)** |        |                                     |
+--------+----+--------+--------+-------------------------------------+
|        | ** | >      | **0**  | **No incidents.**                   |
|        | 22 |  **6** |        |                                     |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
| **07/2 | ** | > **4  | **3**  | **Physics run end. Magnet cooling   |
| 2/02** | 23 | >      |        | system problems.**                  |
|        | ** |  (2)** |        |                                     |
+--------+----+--------+--------+-------------------------------------+
|        | ** | > *    | **2**  | **Magnet problems. Biology run      |
|        | 24 | *2.5** |        | start.**                            |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
| **07/2 | ** | > **5  | **2**  | **RHIC fire alarm. Transport        |
| 3/02** | 25 | > (    |        | problems.**                         |
|        | ** | 1.5)** |        |                                     |
+--------+----+--------+--------+-------------------------------------+
|        | ** | >      | *      | **Sweep lost.**                     |
|        | 26 |  **3** | *0.5** |                                     |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
| **07/2 | ** | > **7  | **0**  | **No incidents.**                   |
| 4/02** | 27 | >      |        |                                     |
|        | ** |  (2)** |        |                                     |
+--------+----+--------+--------+-------------------------------------+
|        | ** | > *    | **0**  | **End NSRL-0**                      |
|        | 28 | *0.5** |        |                                     |
|        | ** |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
|        |    |        |        |                                     |
+--------+----+--------+--------+-------------------------------------+
| **Tot  | ** | **142  | **16   |                                     |
| als:** | 18 | hr.    | hr.    |                                     |
|        | ** | (      | (      |                                     |
|        |    | 89%)** | 11%)** |                                     |
+--------+----+--------+--------+-------------------------------------+

**\*Time loss due to machine or power supply problems, setting up
operations.**

![](media/image16.wmf){width="6.135416666666667in"
height="4.229166666666667in"}

**NSRL-0 operational schedule assumptions:**

-   **7 to 9 am: set-up, initial dosimetry (2 hr)**

-   **9 to 17 pm: experimental run (8 hr)**

-   **17 to 19 pm: contingency and wrap up operations (2 hr)**

> **Total daily operation: 12 hrs**
>
> **NSRL-0 EXPERIMENTERS AND RUN STATISTICS**

+----+--------+------------+------+-------+--------+-------+-------+
| ** | **Pri  | **Ion &    | **   | *     | **Dose | *     | **N   |
| Ex | ncipal | Energy**   | Beam | *Beam | Range  | *Dose | umber |
| p. | In     |            | T.   | Time  | (      | /Rate | of    |
| ID | vestig |            | A    | U     | cGy)** | (     | Samp  |
| ** | ator** |            | ppro | sed** |        | cGy/m | les** |
|    |        |            | v.** |       |        | in)** |       |
+----+--------+------------+------+-------+--------+-------+-------+
| N  | G      | > Fe, 1    | 0.5  | 0.5   | 10-30  | 100   | 50    |
| -9 | ewirtz | > GeV/n    |      |       |        |       |       |
|    |        | >          | 0.5  | 0.5   |        |       |       |
|    |        | > C, 290   |      |       |        |       |       |
|    |        | > MeV/n    | 0.5  | 0.5   |        |       |       |
|    |        | >          |      |       |        |       |       |
|    |        | > Ti, 1    |      |       |        |       |       |
|    |        | > GeV/n    |      |       |        |       |       |
+----+--------+------------+------+-------+--------+-------+-------+
| N- | Kron   | > Fe, 1    | 3    | 5.5   | 15.    | 40-80 | 21    |
| 19 | enberg | > GeV/n    |      |       | 75-189 |       |       |
|    |        | >          | 0    | 3.0   |        | 5     | 21    |
|    |        | > C, 290   |      |       | 14-168 | 0-100 |       |
|    |        | > MeV/n    | 3    | 2.5   |        |       | 21    |
|    |        | >          |      |       | 12.3   | 30-50 |       |
|    |        | > Ti, 1    |      |       | -147.6 |       |       |
|    |        | > GeV/n    |      |       |        |       |       |
+----+--------+------------+------+-------+--------+-------+-------+
| N- | Suth   | > Fe, 1    | 3    | 2.0   | 10 to  | 50    | 200   |
| 73 | erland | > GeV/n    |      |       | 25000  | t     |       |
|    |        | >          | 3    | 2.5   |        | o2000 |       |
|    |        | > C, 290   |      |       |        |       |       |
|    |        | > MeV/n    | 3    | 4.0   |        |       |       |
|    |        | >          |      |       |        |       |       |
|    |        | > Ti, 1    |      |       |        |       |       |
|    |        | > GeV/n    |      |       |        |       |       |
+----+--------+------------+------+-------+--------+-------+-------+
| #  | Green  | > Fe, 1    | 1.5  | 2.5   | 0-50   | 50    | 13    |
| #  |        | > GeV/n    |      |       |        |       |       |
| N- |        |            |      |       |        |       |       |
| 76 |        |            |      |       |        |       |       |
+----+--------+------------+------+-------+--------+-------+-------+
| N- | Nelson | > Fe, 1    | 4.2  | 3.5   | 100 to | 1000  | 100   |
| 77 |        | > GeV/n    |      |       | 1000   |       |       |
|    |        | >          | 4.8  | 3.0   |        |       |       |
|    |        | > C, 290   |      |       |        |       |       |
|    |        | > MeV/n    | 3.4  | 1.0   |        |       |       |
|    |        | >          |      |       |        |       |       |
|    |        | > Ti, 1    |      |       |        |       |       |
|    |        | > GeV/n    |      |       |        |       |       |
+----+--------+------------+------+-------+--------+-------+-------+
| N- | Nelson | > C, 290   | 2.5  | 3.0   | 100 to | 200   | 50    |
| 78 |        | > MeV/n    |      |       | 1000   |       |       |
+----+--------+------------+------+-------+--------+-------+-------+
| N- | Pecaut | > Fe, 1    | 0    | 0.0   | 0-200  | 70-90 | 9     |
| 79 |        | > GeV/n    |      |       |        |       |       |
|    |        | >          | 2.75 | 3.0   | 0-500  | 12    | 54    |
|    |        | > C, 290   |      |       |        | 0-210 |       |
|    |        | > MeV/n    |      |       |        |       |       |
+----+--------+------------+------+-------+--------+-------+-------+
| #  | Gonda  | > Fe, 1    | 2    | 1.5   | 10-200 | 100   | 30    |
| #  |        | > GeV/n    |      |       |        |       |       |
| N- |        | >          | 2    | 2.0   | 20-400 | 200   | 30    |
| 80 |        | > C, 290   |      |       |        |       |       |
|    |        | > MeV/n    |      |       |        |       |       |
+----+--------+------------+------+-------+--------+-------+-------+
| #  | V      | > Fe, 1    | 7    | 9.0   | 0-240  | 40-50 | 140   |
| #  | azquez | > GeV/n    |      |       |        |       |       |
| N- |        | >          | 2    | 1.5   | 0-200  | 40-50 | 50    |
| 81 |        | > C, 290   |      |       |        |       |       |
|    |        | > MeV/n    | 2    | 2.0   | 0-200  | 40-50 | 60    |
|    |        | >          |      |       |        |       |       |
|    |        | > Ti, 1    |      |       |        |       |       |
|    |        | > GeV/n    |      |       |        |       |       |
+----+--------+------------+------+-------+--------+-------+-------+
| N- | O      | > Fe, 1    | 1.3  | 1.0   | 10 to  | 200   | 8     |
| 82 | benaus | > GeV/n    |      |       | 200    |       |       |
|    |        | >          | 1.3  | 2.0   |        |       | 8     |
|    |        | > C, 290   |      |       | 10 to  |       |       |
|    |        | > MeV/n    | 2.3  | 1.0   | 200    |       | 8     |
|    |        | >          |      |       |        |       |       |
|    |        | > Ti, 1    |      |       | 10 to  |       |       |
|    |        | > GeV/n    |      |       | 200    |       |       |
+----+--------+------------+------+-------+--------+-------+-------+
| N- | O      | > Fe, 1    | 5.5  | 4     | 10 to  | 200   | 30    |
| 83 | benaus | > GeV/n    |      |       | 200    |       |       |
|    |        | >          | 5.5  | 1.0   |        |       | 30    |
|    |        | > C, 290   |      |       | 10 to  |       |       |
|    |        | > MeV/n    |      |       | 200    |       |       |
+----+--------+------------+------+-------+--------+-------+-------+
| N- | Cuc    | > Fe, 1    | 4    | 3.0   | 2-300  | 100   | 50    |
| 84 | inotta | > GeV/n    |      |       |        |       |       |
|    |        | >          | 1.5  | 3.5   |        |       |       |
|    |        | > C, 290   |      |       |        |       |       |
|    |        | > MeV/n    | 2.5  | 2.5   |        |       |       |
|    |        | >          |      |       |        |       |       |
|    |        | > Ti, 1    |      |       |        |       |       |
|    |        | > GeV/n    |      |       |        |       |       |
+----+--------+------------+------+-------+--------+-------+-------+
| ** |        |            | **73 | *     | **0-2  | *     | **    |
| To |        |            | .7** | *71** | 5000** | *30-2 | 983** |
| ta |        |            |      |       |        | 000** |       |
| ls |        |            |      |       |        |       |       |
| ** |        |            |      |       |        |       |       |
+----+--------+------------+------+-------+--------+-------+-------+

# 

# 

# 

# 

# NSRL-0 PARTICIPANTS, EXPERIMENTAL SAMPLES AND ENDPOINTS

+----+--------------------+------------------+-------------------------+
| ** | **Participants**   | **Samples**      | **Endpoints**           |
| Ex |                    |                  |                         |
| p. |                    |                  |                         |
| ** |                    |                  |                         |
+----+--------------------+------------------+-------------------------+
| N  | Effects of Deep    | Human bone       | Production of           |
| -9 | Space Radiation on | marrow           | differentiated,         |
|    | Human              | mononuclear      | lineage-specific cells  |
|    | Hematopoietic Stem | cells            | in CFU assays.          |
|    | Cells              |                  |                         |
|    |                    |                  | Alterations in gene     |
|    | **A. Gewirtz       |                  | expression patterns by  |
|    | (PI)**             |                  | microarray analysis.    |
+----+--------------------+------------------+-------------------------+
| N- | Mutagenesis and    | Human lymphoid   | Cell killing            |
| 19 | Genomic            | cells (TK6)      | comparisons to          |
|    | Inestability in    |                  | previously published    |
|    | Human cells        |                  | results, colony         |
|    |                    |                  | formation and survival  |
|    | **A. Kronenberg    |                  | curves.                 |
|    | (PI)**             |                  |                         |
+----+--------------------+------------------+-------------------------+
| N- | DNA damage         | T7 DNA           | DNA damage cluster      |
| 73 | clusters in low    |                  | induction and repair at |
|    | level radiation    | Human bone       | the molecular and       |
|    | responses of human | marrow cells     | cellular levels.        |
|    | cells.             |                  |                         |
|    |                    | Human monocytes  |                         |
|    | **B. Sutherland    |                  |                         |
|    | (PI)**             | Supercoiled DNA  |                         |
+----+--------------------+------------------+-------------------------+
| N- | Response of        | FRTL-5 cells     | Gene expression         |
| 76 | Thyroid Tissue     | (rat thyroid)    | alterations.            |
|    | Units to           |                  |                         |
|    | Space-Like         |                  |                         |
|    | Radiation Fields.  |                  |                         |
|    |                    |                  |                         |
|    | **L. Green (PI)**  |                  |                         |
+----+--------------------+------------------+-------------------------+
| N- | Carbon Radiation   | C57BL/6 Mice     | Gene expression using   |
| 78 | Induced Gene       |                  | microarray analysis.    |
|    | Expression in      |                  |                         |
|    | C57BL/6 Mice.      |                  |                         |
|    |                    |                  |                         |
|    | **G. Nelson (PI)** |                  |                         |
+----+--------------------+------------------+-------------------------+
| N- | The Effects of     | C45BL/6 Mice     | Interleukin-1           |
| 79 | Head-Only and      |                  | expression using        |
|    | Whole-Body         |                  | immunohistochemical     |
|    | Irradiation on     |                  | (IHC) and MRI analysis. |
|    | CNS-Immune         |                  |                         |
|    | Function.          |                  |                         |
|    |                    |                  |                         |
|    | **M. Pecaut (PI)** |                  |                         |
+----+--------------------+------------------+-------------------------+
| N- | Comparison of Cell | Normal &         | Mutation types and      |
| 80 | and Tissue 3D      | Transgenic       | frequency induced in    |
|    | Models for         | fibroblast cells | target genes at         |
|    | Assessment of      |                  | molecular level         |
|    | Genotoxic Damage   | Normal &         |                         |
|    | by High Energy     | Transgenic       | Dose relationships      |
|    | Charged Particles. | epithelial cells |                         |
|    |                    |                  |                         |
|    | **S. Gonda (PI)**  |                  |                         |
+----+--------------------+------------------+-------------------------+
| N- | In Vitro and In    | C57BL/6 Mice     | Behavioral Testing:     |
| 81 | Vivo CNS Damage    |                  | Locomotor activity      |
|    | Studies            | NT-2 neural stem |                         |
|    |                    | cells            | Survival, apoptosis,    |
|    | **M. Vazquez       |                  | gene expression         |
|    | (PI)**             | hNT post-mitotic |                         |
|    |                    | neurons          |                         |
+----+--------------------+------------------+-------------------------+
| N- | Dosimetry Gels     | Dosimetry Gels   | A more complete dose    |
| 82 | (Magic Gels) as    | (Magic Gels)     | response curve.         |
|    | Biological         |                  |                         |
|    | Reporters of       |                  |                         |
|    | Radiation Dose.    |                  |                         |
|    |                    |                  |                         |
|    | **A. Obenaus       |                  |                         |
|    | (PI)**             |                  |                         |
+----+--------------------+------------------+-------------------------+
| N- | Changes in         | Sprague-Dawley   | Neuroimaging using MRI  |
| 83 | Neuronal           | Rats             | and MRS.                |
|    | Excitability       |                  |                         |
|    | Following ^56^Fe   |                  |                         |
|    | and Carbon         |                  |                         |
|    | Irradiation:       |                  |                         |
|    | Correlation of     |                  |                         |
|    | El                 |                  |                         |
|    | ectrophysiological |                  |                         |
|    | Alterations with   |                  |                         |
|    | Magnetic Resonance |                  |                         |
|    | Imaging.           |                  |                         |
|    |                    |                  |                         |
|    | **A. Obenaus       |                  |                         |
|    | (PI)**             |                  |                         |
+----+--------------------+------------------+-------------------------+
| N- | Comparison of      | Normal human     | Cytogenetic damage      |
| 84 | Cytogenetic Damage | lymphocytes and  |                         |
|    | measured at the    | fibroblasts      | DNA double strand       |
|    | NASA Space         |                  | breaks and repair by    |
|    | Radiation          |                  | immuno staining.        |
|    | Laboratory (NSRL)  |                  |                         |
|    | to Results from    |                  |                         |
|    | AGS and HIMAC.     |                  |                         |
|    |                    |                  |                         |
|    | **F. Cucinotta     |                  |                         |
|    | (PI)**             |                  |                         |
+----+--------------------+------------------+-------------------------+
|    |                    |                  |                         |
+----+--------------------+------------------+-------------------------+

**List of personnel that participated in the planning, organization and
execution of NSRL-0 run**

**[BNL Management:]{.underline}**

-   Laboratory Director: **Peter Paul**

-   Associate Director for High Energy and Nuclear Physics**: Tom Kirk**

-   Associate Laboratory Director for Life Sciences: **Helene
    Benveniste**

**[NASA Management:]{.underline}**

-   Headquarters: **Walter Schimmerling, David Tomko**

-   JSC: **Frank Cucinotta[,]{.underline} Frank Sulzman, Barbara
    Corbin**

**[Scientific Advisory Committee:]{.underline}**

-   **Betsy Sutherland** (Chair), BNL

-   **Louis Pena,** BNL

-   **Richard Setlow,** BNL

-   **Joel Bedford,** CSU

-   **Les Braby,** PNL

-   **Charles Geard,** Columbia University

**[Collider Accelerator Department-AGS]{.underline}**

-   Chairman: **Derek Lowenstein**

-   Deputy Chairman: [**W.T.
    Weng**](http://www.ccd.bnl.gov/cgi-bin/ph/ns.bnl.gov?alias%3Dweng)

-   Associate Chair of Operations: [**A.J.
    McNerney**](http://www.ccd.bnl.gov/cgi-bin/ph/ns.bnl.gov?mcnerney)

-   Experimental Planning and Support Head: **Philip Pile**

```{=html}
<!-- -->
```
-   Associate Chair for ESHQ: ** Ed Lessard**

-   ESHQ Division Head: **Ray Karol** ** **

-   ESH Coordinator: ** Asher Etkin** ** **

-   Facility Support Representative: **Chuck Schaefer / Henry
    Kahnhauser **

-   Environmental Coordinator: **Joel Scott** ** **

-   Training and Procedures Manager : **John Maraviglia** ** **

-   Main Control Room: **Peter Ingrassia** ** **

-   Work Control Manager: **Peter Cirnigliaro** ** **

-   BNL Laser Safety Officer: **Chris Weilandics** ** **

-   Experimental Safety Review Committee: **Yousef Makdisi (Chair)**
    ** **

-   Radiation Safety Committee: **Dana Beavis (Chair)** ** **

-   **Acc**elerator Safety Review Committee: **Woody Glenn (Chair)**
    ** **

-   ALARA Committee: **Chuck Schaefer (Chair**

```{=html}
<!-- -->
```
-   Associate Chair for ES&H/Q.A: [**E.
    Lessard**](http://www.ccd.bnl.gov/cgi-bin/ph/ns.bnl.gov?alias%3Dlessard)

-   Accelerator Division Head: **Thomas Roser**

-   Chief Electrical Engineer: [**J.
    Sandberg**](http://www.ccd.bnl.gov/cgi-bin/ph/ns.bnl.gov?alias%3Djsandberg)

-   Chief Mechanical Engineer: [**J.
    Tuozzolo**](http://www.ccd.bnl.gov/cgi-bin/ph/ns.bnl.gov?tuozzolo)

-   Accelerator Physicist lead by: **Leif Aherns**

-   Tanden Group leader: **Peter Thieberger**

-   Physics Support: **Yusef Makadisi**

-   CAD Components and instrumentation support: **David Gassner**

-   AGS Radiation Safety Committee: **Ken Reece**

-   C-A Dept Training Manager: **John Maraviglia**

-   AGS Control Section lead by: **Don Barton**

-   Liaison Engineering Group lead by: **David Phillips**

-   Liaison physicist: **Adam Rusek**

-   RHIC&AGS Users Center: **Susan White-DePace, Angela Melocoton**

-   Mechanical Service Technicians led by: **Fred Kobasiuk**

-   Survey Group led by: **Frank Karl**

-   Beam Service Technicians led by**: Paul Valli**

-   Electronic Service Technicians led by: **Bill Anderson**

-   AGS Instrumentation Group led by: **Pete Stillman**

-   AGS Main Control Room and Operations led by: **Pete Ingrassia**

-   **AGS MCR Operation Coordinators:**

> **Jim Jamilkowski**
>
> **Greg Marr**
>
> **Sanjee Abeytunge**
>
> **Jennifer Kozak**
>
> **Brian van Kuik,**
>
> **Travis Shrey**

-   AGS Electricians led by **Bill Softye**

-   AGS Riggers led by: **Nick Cipolla**

-   Carpenter and Welder Support Service and Technical Support led by:
    **Roger Hubbard**

**[Dosimetry:]{.underline}**

-   **Don Lazarus**

-   **Adam Rusek**

-   **I-Hung Chiang**

-   **Kin Yip**

-   **Peter Oddo**

-   **Bart Frak**

**[Medical Department:]{.underline}**

> **NASA LTSF TEAM:**

-   **Medical Liaisons: Marcelo E. Vazquez, Peter Guida**

-   **Technical support: Bea Pyatt, Stacey Russell, Adele Billups**

-   Dept. Chair: **John Gatley**

-   Building Manager: **Chris Harris**

-   Administration: **Denise White and Donna Russo**

-   Animal Care Facilities: **Maryann Kershaw, Kerry Bonti, Patricia
    Leone**

-   Training Coordinator: **Ann Emrick**

```{=html}
<!-- -->
```
-   **[RCD]{.underline}**

-   Kay Conkling

-   Dennis Ryan

-   Deana Buckallew

-   Jim Williams

-   Bob Colichio

**[Plant Engineering:]{.underline}**

-   BLAF Custodian, **P. Abrams**

-   Plumbers: **B. McCafferty**

-   Painters/Carpenters: **B. Laakmann**

-   Electricians: **T. Baldwin**

[**Biology Department**:]{.underline}

-   Chairman: **Carl Anderson**

-   Biology Liason: **Betsy Sutherland**

-   Technical Support: **Mamta Naidu, Debasish Roy**

-   Cesiun Source Manager: **Richard Sautkulis**

    **[Lawrence Berkeley National Laboratory Dosimetry Technical
    Suppoer:]{.underline}**

-   **R. P. Singh**

**NSRL-0 PICTORIAL**

![](media/image17.jpeg){width="5.510416666666667in"
height="4.135416666666667in"}