***[CURRICULUM VITAE]{.underline}*** February, 2007

[Name]{.underline}: Ofelia Ana Olivero

[Date and Place of Birth]{.underline}: October 14, 1956; Argentina.

[Immigration Status]{.underline}: American Citizen, Naturalized, March
16, 2000

[Present Address]{.underline}:

Home: 1249 Derbyshire Road, Rockville, MD 20854-6161

Phone: 301-738-1187

Work: Laboratory of Cancer Biology and Genetics, National Cancer
Institute, National Institutes of Health

37 Convent Drive, MSC 4256, Bldg. 37, Rm. 4032

Bethesda, MD 20892-4255

Phone: 301-435-7843 Fax: 301-402-8230

Email: oliveroo@exchange.nih.gov

[Education]{.underline}:

1978 M.S. (Zoology) Faculty of Natural Sciences and Museum, National

University of La Plata, Argentina.

1985 Ph.D. (Natural Sciences) Faculty of Natural Sciences

National University of La Plata, Argentina.

[Brief Chronology of Employment]{.underline}:

1975-1978 - Instructor of Histology and Embryology, Faculty of Natural
Sciences and Museum of La Plata, La Plata, Argentina.

1980‑1981 ‑ Assistant Professor of Biology, Faculty of Natural Sciences

and Museum of La Plata, La Plata, Argentina.

1985-1986 - Assistant Professor of Evolution, Faculty of Natural
Sciences of La Plata, La Plata, Argentina.

1985-1989 - Scientific Researcher at Instituto Multidisciplinario de
Biologia Celular (IMBICE), Argentina.

1987-1990 - Visiting Fellow, Laboratory of Cellular Carcinogenesis and
Tumor Promotion, Division of Cancer Etiology, National Cancer Institute,
National Institutes of Health, Bethesda, MD.

1990 Guest Researcher, Laboratory of Cellular Carcinogenesis and Tumor
Promotion, Division of Cancer Etiology, National Cancer Institute,
National Institutes of Health, Bethesda, MD.

1990-1998 - Visiting Associate, Laboratory of Cellular Carcinogenesis
and Tumor Promotion, Division of Basic Sciences, National

Cancer Institute, National Institutes of Health, Bethesda, MD.

1998-Date - Staff Scientist. CCR. National Cancer Institute, National
Institutes of Health, Bethesda, MD

[Societies]{.underline}:

American Association for Cancer Research (Active member)

American Society for Cell Biology

American Association for the Advancement of Science

Genetic Toxicology Association

Society of Toxicology

[Grants]{.underline}:

Council of Research of the Province of Buenos Aires. Two year Salary
Grant to work in Toxicological Genetics, 1979.

Council of Research of the Province of Buenos Aires. Two year Salary
Grant to work in Toxicological Genetics, 1980.

[Honors and Awards]{.underline}:

Scholarship from The National Research Council of Argentina (2 years),
1981.

Scholarship from the National Research Council of Argentina (2 years),
1983.

Travel Award from the American Association for Cancer Research (AACR) to
attend the 85^th^ Annual AACR Meeting, 1984.

Travel Award from Bristol-Myers to Attend the 86^th^ Annual Meeting of
the American Association for Cancer Research 1995.

Travel Grant from the International Society for Preventive Oncology to
attend the 3rd International Symposium on Impact of Cancer Biotechnology
on Predictive Oncology & Therapy, 1996.

Recognition Award. National Cancer Institute. Laboratory of Cellular
Carcinogenesis and Tumor Promotion, 1996.

NCI On the Spot Award. Laboratory of Cellular Carcinogenesis and Tumor
Promotion (05/11/00).

NCI On the Spot Award. Laboratory of Cellular Carcinogenesis and Tumor
Promotion (10/03/00).

NCI Director\'s Leading Diversity Award, 2003.

Incentive Award, Laboratory of Cellular Carcinogenesis and Tumor
Promotion (05/10/05).

NCI On the Spot Award. Laboratory of Cellular Carcinogenesis and Tumor
Promotion (10/01/06).

Exceptional Performance Award, Laboratory of Cancer Biology and
genetics, 02/02/07)

[Honorable Poster Awards:]{.underline}

Cooch, C. Vazquez, I.L. Poirier, M.C. and Olivero O.A. Zidovudine
(AZT)-phosphorylation and resistance is mediated by thymidine kinase 1
inhibition. [Fellows and Young Investigators Retreat]{.underline},
National Cancer Institute, Williamsburg, 2005.

Sirajuddin, P, Castle, P. E.., Schiffman, M., Glass, A.G., Scott, D.R.,
Rush, B.B., Olivero, O.A., Poirier, M.C. and Pratt, M.M. [Fellows and
Young Investigators Retreat]{.underline}, National Cancer Institute,
Williamsburg, 2005

[Reviewer for:]{.underline}

Argentine Council for Scientific Research, 1998.

The Wellcome Trust. Cambridge. International Funding, 1999.

John Simon Guggenheim Memorial Foundation, 2001.

National Toxicology Program. Developmental Toxicity of AZT and 3TC
co-administered by gavage to CD1 mice on gestational days 6 through 16,
2003.

[Referee for:]{.underline}

-American Journal of Industrial Medicine

-Antiviral Research

-Cancer Research

-Cancer Chemotherapy and Pharmacology

-Cancer Letters

-Carcinogenesis

-Cell Growth and Differentiation

-Environmental Research

-Environmental Health Perspectives

-Journal of AIDS

-Journal of the National Cancer Institute

-Journal of Investigative Dermatology

-Journal of Infectious Diseases

-Molecular and Cellular Biochemistry

-Mutagenesis

-Toxicological Sciences

[Professional advisory activities inside NIH]{.underline}

-Voting Member. Technical Evaluation Panel for the Laboratory of Human
Carcinogenesis. National Cancer Institute.

-Member of the selection committee of the ICRC ( Introduction to Cancer
Research Careers), from NCI.

-Preceptor, Howard Hughes Research Scholars, years 1999 to 2001.

-Mentor for the Teachers program of the Howard Hughes Research, years
2001-2006

-Elected at-large Member of the NIH Hispanic Employee Organization,
2002-2003.

-President Elect, NIH Hispanic Employee Organization, year 2003-2004.

-President, NIH-Hispanic Employee Organization, year 2005-2006.

-Board member HHS-Hispanic Employee Organization, year 2005-2006.

-Member Steering Committee, Staff Scientists/Staff Clinicians
Organization, CCR, NCI.

-Member Steering Committee, Staff Scientists/Staff Clinicians
Organization, NIH.

-Co-chair Staff Scientists/Staff Clinicians organization CCR, NCI. 2007.

[Professional advisory activities outside NIH]{.underline}:

-Poster award judge. The Third International Conference on Environmental
Mutagens in Human Populations, Bangkok, Thailand.

-Judge, oral presentations in Biology at 32 Annual Meeting of SACNAS,
Albuquerque NM.

-Member of the Public Relations Committee, Environmental Mutagenesis
Society.

-Member of the Student Affair Committee, Environmental Mutagenesis
Society.

-Member Board of Directors of the Genetic Toxicology Association (2005,
2006).

**-**Member of the Abstract Review Committee SACNAS National Conference.
(2004, 2005, 2006).

**-**Member of the MICR Communications Committee, American Association
for Cancer Research, (2005-2006).

**-**Member of the Interim Steering Committee of the Hispanic
Organization for Toxicologists from the Society of Toxicology.

**-**Co-chair of the Membership and Professional Development committee
of the Environmental Mutagenesis Society.

\- Chair of the Genetic Toxicology Association (GTA), year 2006-07.

[Lecturer for:]{.underline}

-NIH Office of Science Education Bureau of Speakers.

-NCI Summer Curriculum in Cancer Prevention. Molecular Prevention
Course. Division of Cancer Prevention. NIH, Bethesda, MD. The DNA Damage
Response.

[Doctoral Thesis Advisor:]{.underline}

-Patricia Escobar. The Graduate School of Public Health Department of
Environmental and Occupational Health. University of Pittsburgh, June
2001.

[Organizer for]{.underline}:

-Co-organizer, NIH-Third Hispanic Scientist Day. NIH, Bethesda, MD.
October 2002.

-Co-organizer, NIH-Fourth Hispanic Scientist Day. NIH, Bethesda, MD.
October 2003.

-Co-organizer, CCR, NCI First Staff Scientists/Staff Clinicians Retreat
. Bethesda, MD. April 2005.

-Co-organizer of the 2005 Fall Meeting of the Genetic Toxicology
Association, Newark, DE.

-Co-organizer of the CCR, NCI Staff Scientist Staff Clinicians 2006
Annual Retreat.

-Organizer of the Seminar Series of the Laboratory of Cellular
Carcinogenesis and Tumor Promotion (LCCTP) for the season 2005-06.

Organizer of the Seminar Series of the Laboratory of Cancer Biology and
Genetics (LCBG) for the season 2006-07.

-Co-organizer of the Women in Toxicology Sponsored Symposium "Women's
Health Initiative: Lessons Learned and Future Directions", to be
presented at the Annual Society of Toxicology Meeting, Charlotte, NC,
March 2007.

-Co-Organizer 2006 Spring Meeting of the Genetic Toxicology Association:
Molecular Markers of Carcinogenesis. Newark, DE, April 2007.

[Session Chair and/or Panel Discussant for]{.underline}:

-Chairperson. Effects of Genotoxic Agents. The Third International
Conference on Environmental Mutagens in Human Populations, Khao Yai,
Thailand, 1998.

-Chairperson. DNA adducts, Mutagenesis, and Repair. Minisymposium.
American Association for Cancer Research, Philadelphia, PA, April, 1999.

-Chairperson Environmental Agents Session. Annual Meeting of the
Environmental Mutagen Society, Miami FL, September 2002.

-Chairperson 32 Annual Meeting of SACNAS, Albuquerque NM, October 2003.

-Chairperson, Anticancer Therapy Session. 7^th^ International Symposium
on Molecular Basis of Predictive Oncology Intervention & Strategies.
Nice, France, February 2004.

-Chairperson, Fifth NIH-Hispanic Scientist Day, NIH, Bethesda, MD.
October 2004.

-Co-Chair 2005 Fall Meeting of the Genetic Toxicology Association: Hot
topics in Genetic Toxicology. Newark, DE, October 2005.

-Co-Chair of the Women in Toxicology Sponsored Symposium "Women's Health
Initiative: Lessons Learned and Future Directions". Annual Society of
Toxicology Meeting, Charlotte, NC, 2007.

-Co-Chair 2007 Spring Meeting of the Genetic Toxicology Association.
Biomarkers of Carcinogenesis, Newark, DE, April 2007.

[Invited speaker]{.underline}:

-Immunolocalization of compounds bound to and incorporated into
chromosomal DNA. Division of Biochemical Toxicology, NCTR, Jefferson,
AK, 1991.

-AZT and chromosomes. Lawrence Livermore Lab., Livermore, CA, 1992.

-Immunolocalization. 11^th^ Latin American Conference on Genetics Puerto
Vallarta, Mexico, 1994.

-Fluorescent *in situ* hybridization (FISH).11^th^ Latin American
Conference on Genetics, Puerto Vallarta, Mexico, 1994.

-AZT, chromosomes and cancer. Laboratory of Comparative Carcinogenesis,
NCI, FCRDC, Frederick, MD, 1995.

-AZT, chromosomes and cancer, American Type Culture Collection,
Rockville, MD, 1996.

-Telomere shortening by long-term and transplacental AZT treatment.
IARC, Lyon, France, 1996.

-Telomere shortening by long‑term and transplacental AZT Gerontology
Research Center, Baltimore, MD, 1996.

-AZT, chromosomes and cancer. Microbiological Associates, Rockville, MD,
1997

-Fetal mouse and monkey genotoxic mechanisms and mouse transplacental
tumorigenicity of AZT administration during gestation. Pediatric
Oncology Branch, National Cancer Institute, Bethesda, MD, 1997.

-AZT is a transplacental carcinogen in mouse. University of Maryland,
Baltimore, MD, 1997.

-AZT, a genotoxic transplacental carcinogen in rodents, is incorporated
into human fetal and maternal DNA. National AIDS Malignancy Conference,
NIH, Bethesda, MD, 1998.

-3\'-azido-3\'-deoxythymidine (AZT) transplacental perfusion kinetics
and DNA incorporation in normal human placentas perfused with AZT. Khao
Yai, Thailand, 1998.

-AZT, chromosomes and cancer. Laboratory of Cellular Carcinogenesis and
Tumor Promotion, NCI, NIH. Bethesda. MD, 1999.

-Incorporation of 3\'-Azido-3\'-deoxythymidine (AZT) into peripheral
blood DNA of HIV-1 positive adults and cord blood DNA of infants.
American Association for Cancer Research, 89^th^ Annual Meeting,
Philadelphia, PA, 1999.

-Science at NCI .Speaker for the Comprehensive Minority Biomedical
Branch Intramural Laboratory Site Visits, NCI, 2000.

-HIV-1 Antiretroviral therapy and cancer. Laboratory of Cellular
Carcinogenesis and Tumor Promotion, NCI, NIH, Bethesda. MD. 2000.

-Minorities in Science at NIH. Host and Speaker Office of Special
Population Research. College CURE Interns. College of Physicians and
Surgeons NIH, Bethesda, MD. 2000.

-Genotoxic Risks of perinatal exposures to Antiviral Reverse
Transcriptase Inhibitors. 32nd EMS Meeting, San Diego CA. April, 2001.

-Genotoxicity of AZT in mother-infant pairs. Minisymposium.
Mitochondrial Dysfunction and Genotoxicity Induced by Transplacental
Antiretroviral Nucleoside Reverse Transcriptase (NRTI) Exposures. NCI,
NIH. Bethesda, MD, 2002.

-NCI scientific opportunities for minorities. Career Opportunities for
Scientists speaker series, sponsored by the Ernest E. Just Biomedical
Society at the University of Pennsylvania, 2002.

-AZT a nucleoside analog with carcinogenic activity. Cancer Research
Center of Hawaii. Honolulu, HI, 2003.

-Transplacental carcinogenesis of the anti-AIDS drug AZT. Genetic
Toxicology Association. Spring Meeting, Delaware, 2003.

-Carcinogenesis induced by anti AIDS drugs. School of Medicine,
University of Miami, Department of Cell Biology and Anatomy. Miami,
Florida 2003.

-The genotoxicity of antiretroviral nucleoside analog drug combinations
in human lymphoblastoid cells. 7^th^ International Symposium on
Molecular Basis of Predictive Oncology Intervention & Strategies. Nice,
France February 10, 2004.

-Genotoxicity and cell cycle expression changes induced by nucleoside
reverse transcriptase inhibitors (NRTIs). 35^th^ Annual Meeting of the
Environmental Mutagen Society, Pittsburgh, PA, October 3, 2004.

-HIV-1 Antiretroviral therapy and Carcinogenesis. Laboratory of Cellular
Carcinogenesis and Tumor Promotion, LCCTP. CCR NCI, NIH, Bethesda, MD.
December, 9, 2004.

-Genotoxicity of antiretrovirals. Department of Pharmaceutical Sciences,
School of Pharmacy, University of Southern California, Los Angeles, CA,
April 2005.

-Cyclin D-Rb Pathway is Altered during Continuous Exposure of MOLT-3
Human lymphoblastoid Cells to the Antiretroviral Drug Zidovudine (AZT).
9th International Conference on Environmental Mutagens (9^th^ ICEM) San
Francisco, CA September 2005.

-Antiretroviral therapy and Cancer. Sigma Delta Epsilon Graduate Women
in Science, Omicron Chapter, Bethesda, MD. September 12, 2005.

-AIDS vs Cancer. Are antiretrovirals safe? Keynote speaker, NIH Hispanic
Scientist Day, Bethesda, MD. October 2005.

-Understanding the genotoxicity of antiretroviral therapy: Postbacc-IRTA
contributions. Postbaccalaureate Lecture Series, National Institutes of
Health, Bethesda MD. October 2005.

-Understanding the genotoxicity of antiretroviral therapy: Student
contributions. Elizabeth Sommers Women's Leadership Program. The George
Washington University. March 2006.

-Transplacental genotoxicity of antiretroviral drugs: Are
antiretrovirals safe? Dept. of Environmental and Molecular Toxicology,
Oregon State University. March 2006

-Women's health, antiretrovirals and cancer. International Women's Day.
NIH, Bethesda, MD. March 2006.

-What can we learn from a mouse? National Library of Medicine NIH,
Bethesda, MD. March-May, September, December 2006.

-Host of the Intercultural Cancer Council, 10^th^ Biennial Symposium on
Minorities, the Medically undeserved and Cancer. National Cancer
Institute April 20, 2006

\- International Course Alexander Hollaender:"Genetic Toxicology:
Nutritional and Environmental Perspectives". Cell Cycle, Centrosomes and
Cancer. Genotoxicity of the antiretroviral drug AZT in hamster and human
cells *in vitro.* Concepcion, Chile, October 2006

-Postbaccalaureate Lecture Series, National Institutes of Health,
Bethesda MD. October 2006. Cell cycle centrosomes and cancer. NIH,
Bethesda, MD.

> -Antiretroviral Therapies and its consequences. Northwest High School,
> Germantown, MD. December 2006.
>
> -Keynote Speaker at the 7th Annual Scientific Symposium for the
> Houston Premedical Academy Baylor College of Medicine, Houston, TX,
> January 2007. 

-What can we learn from a mouse? National Library of Medicine NIH,
Bethesda, MD. January, March, 2007.

[Community outreach invited lectures:]{.underline}

-Why Science? Summer Series. Hispanic Center of Virginia. 2003.

-Science as a Career. Health Care Career Club Meeting, Bladensburg MD.
March 15, 2004.

-Science as a career. Thomas Edison High School of Technology,
Biotechnology camp. Silver Spring, MD. July 12, 2005.

-Introduction to Science Careers for minorities. Carnegie Institution of
Washington. McKinley Technology HS. Washington, DC. August 9, 2005.

-Why Science? Walter Johnson High School. Bethesda MD. October 2005.

-Career Fair Center for Child Protection and Family Support. Washington,
DC. June 2006.

BIBLIOGRAPHY

1\. Dulout, F. N., Larramendy, M. L. and Olivero, O. A.: Enhancement by
caffeine of the frequency of anaphase‑telophase chromatin bridges
induced by TEM. [Experientia]{.underline} 36: 346‑347, 1980.

2\. Larramendy, M. L., Dulout, F. N., Bianchi, N. O. and Olivero, O. A.:
*In vivo* dose‑response relationship in bone marrow cells of mice
treated with Adriamycin. [Mutation Res]{.underline}. 79: 133‑140, 1980.

3\. Dulout, F. N., Larramendy, M. L. and Olivero, O. A. Mecanismos
Robertsonianos: evidencias experimentales. Actas del IV Congreso
Latinoamericano X Argentino de Genetica, Vol. 2: 261-266, 1980.

4\. Dulout, F. N., Olivero, O. A. and Larramendy, M. L.: Effect of
caffeine on the frequency of chromosome aberrations induced by TEM and
ADR in mice. [Mutation Res]{.underline}. 82: 295‑304, 1981.

5\. Dulout, F. N., Olivero, O. A., von Guradze, H. N. and Pastori, M.
C.: Cytogenetic effect of Malathion assessed by the micronucleus test.
[Mutation Res]{.underline}. 105: 413‑416, 1982.

6\. Dulout, F. N., Pastori, M. C., Olivero, O. A., y von Guradze, H. N.:
Los ensayos citogeneticos in vivo en estudios de mutagenesis quimica.
Actas del V Congreso Latinoamericano de Genetica, 209-225, 1982.

7\. Dulout, F. N., Olivero, O. A. and Pastori, M. C.: The mutagenic
effect of Thiram analysed by the micronucleus test and the
anaphase‑telophase test. [Mutation Res]{.underline}. 103: 409‑412, 1982.

8\. Dulout, F. N., Pastori, M. C. and Olivero, O. A.: Malathion induced
chromosome aberrations in bone marrow cells of mice: dose-response
relationships. [Mutation Res]{.underline}. 122: 163‑167, 1983.

9\. Dulout, F. N. and Olivero, O. A.: Anaphase‑telophase analysis of
chromosomal damage induced by chemicals. [Environ. Mut.]{.underline} 6:
299‑310, 1984.

10\. Dulout, F. N., Pastori, M. C., Olivero, O. A., Gonzalez, Cid, M.,
Loria, D., Matos, E., Sobel, N., de Bujan, E. C. and Albiano, N. Sister
chromatid exchanges and chromosomal aberrations in a population exposed
to pesticides. [Mutation Res]{.underline}. 143: 237-244, 1985.

11\. Olivero, O. A., Lopez Camelo, J. S., Lopretto, E. C. and Bianchi,
N. O. CAC: A computer system to detect homologies through chromosome arm
comparisons. [Caryologia]{.underline} 40: (4) 275-286, 1987.

12\. Bianchi, N. O., Lopez Camelo, J. S., Olivero, O. A. and Lopretto,
E. C.: An equation to determine the index of karyological conservatism
among phylogenetically related species. [Caryologia]{.underline} 41: (1)
9-15, 1988.

13\. Olivero, O. A., Huitfeldt, H. S. and Poirier, M.C.: Chromosome
site-specific immunohistochemical detection of DNA adducts in
N-acetoxy-acetylaminofluorene exposed CHO cells. [Molecular
Carcinogenesis]{.underline}. 3: (1) 37-43, 1990.

14\. Olivero, O. A., Semino, M. C. and Poirier, M. C.: Localization of
DNA-adducts by N-acetoxy-N-2-acetyl-aminofluorene in chinese hamster
ovary cells using electron microscopy and colloidal gold, [Genes,
Chromosomes and Cancer]{.underline} 2: 130-136, 1990.

15\. Olivero, O. A. and Poirier, M. C.: Preferential incorporation of
3\'‑azido‑2\',3\'‑dideoxythymidine (AZT) into telomeric DNA and
Z‑DNA‑containing regions of Chinese hamster ovary cells. [Mol.
Carcinog]{.underline}., 8(2): 81-88, 1993.

16\. Olivero, O. A., Beland, F. A. and Poirier, M. C.: Immunofluorescent
localization and quantitation of 3\'-azido-2\',3\'-dideoxythymidine
(AZT) incorporation into chromosomal DNA of human, hamster, and mouse
cell lines. [Int. J. of Oncol]{.underline}. 4: 49-54, 1994.

17\. Olivero, O. A. and Ahmed Kassim.: Purification of mitochondrial DNA
using Qiagen columns. [Qiagen. Bull]{.underline}. November, 1994.

18\. Olivero, O. A., Beland, F. A., Fullerton, N. F. and Poirier, M. C.:
Vaginal epithelial DNA damage and expression of preneoplastic markers in
mice during chronic dosing with tumorigenic levels of
3\'-azido-2\',3\'-dideoxythymidine (AZT). [Cancer Res]{.underline}. 54:
6235-6242, 1994.

19\. Olivero, O. A., Semino, C., Kassim, A., Lopez-Larraza, D. M. and
Poirier, M. C.: Preferential binding of cisplatin to mitochondrial DNA
of Chinese hamster ovary cells. [Mutat. Res]{.underline}. 346: 221-230,
1995.

20.Gomez, D. E., Kassim, A. and Olivero, O. A.: Preferential
incorporation of 3\'-azido-2\',3\'-dideoxythymidine (AZT) in telomeric
sequences of CHO cells. [Int. J. Oncol]{.underline}. 7: 1057-1060, 1995.

21\. Giurgiovich, A.J., Diwan, B. A., Olivero, O.A., Anderson, L.M.,
Rice, T. J. and Poirier, M.C.: Elevated mitochondrial cisplatin-DNA
adduct levels in rat tissues after transplacental cisplatin exposure.
[Carcinogenesis]{.underline} 17: 1665-1669, 1996.

22\. Giurgiovich, A.J., Anderson, L.M., Jones A.B., Dove, L.F., Moskal,
T.J., Rice, J.M., Olivero, O.A., and Poirier, M.C.: Transplacental
cisplatin exposure induces mitochondrial and genomic DNA damage in Patas
monkeys. [Reproductive Toxicol]{.underline} 11(1):95-100,1997.

23\. Agarwal, R. P., and Olivero, O. A.: Genotoxicity and mitochondrial
damage in human lymphocytic cells chronically exposed to
3\'-azido-2\',3\'-dideoxythymidine (AZT) [Mutation Research]{.underline}
390(3):223-231,1997.

24\. Olivero, O.A., Chang, P., Lopez‑Larraza, D.M., Semino, M.C. and
Poirier, M.C.: Preferential formation and decreased removal of
cisplatin-DNA adducts in Chinese hamster ovary (CHO) cell mitochondrial
DNA as compared with genomic DNA. [Mutation Research]{.underline}
391(1,2):79-86, 1997.

25\. Olivero, O.A., Anderson, L.M., Diwan, B.A., Haines, D.C., Harbaugh,
S.W., Moskal, T.J., Jones, A.B., Rice, J.M., Riggs, C.W., Logdson, D.,
Yuspa, S.H. and Poirier, M.C. Transplacental effects of
3\'-azido-2\',3-dideoxythymidine (AZT): Tumorigenicity in mice and
genotoxicity in mice and monkeys. [JNCI]{.underline}: 89 (21):1602-1608,
1997.

26\. Gomez, D.E., Tejera, A.M. and Olivero, O.A. Irreversible telomere
shortening by 3\'-azido-2\',3-dideoxythymidine (AZT) treatment.
[Biochemical and Biophysical Research Communications]{.underline}, 246
(1):107-110, 1998.

27\. Zhang, Z. Anderson, L. M., Diwan, B.A., Olivero, O.A. Haines, D.C.,
Rice, J.M., Yuspa, S.H., and Poirier, M.C. Skin tumorigenesis and K-ras
gene mutations in tumors from adult mice exposed in utero to
3\'-azido-2\',3-dideoxythymidine (AZT).[Molecular
Carcinogenesis]{.underline}, 23:45-51, 1998.

28\. Olivero OA, Gomez DE. RE: S. M. Melana et al., Inhibition of cell
growth andtelomerase activity of breast cancer cells in vitro by 3
\'-azido-3 \'-deoxythymidine. Clin.Cancer Res., 4 : 693-696, 1998. [Clin
Cancer Res]{.underline} 4: 2569-2569 OCT 1998

29\. Olivero, O.A., Parikka, R., Poirier, M.C. and Vähäkangas, K.,
3\'-azido-3\'-deoxythymidine (AZT) transplacental perfusion kinetics and
DNA incorporation in normal human placentas perfused with AZT. [Mutation
Research-Fund. Mol. M.]{.underline} 428: 41-47, 1999

30\. Olivero, O.A, Shearer, M.S., Chougnet C.A., Kovacs, A.S., Landay,
A.L., Baker, R., Stek, A.M., Khoury, M.M., Proia, L.A., Kessler, H.A.,
Sha, B.E. Tarone, R.E. and Poirier, M.C. Incorporation of Zidovudine
into peripheral blood DNA of HIV-1 positive adults, cord blood DNA of
infants and peripheral blood DNA of their HIV-1 positive mothers.
[AIDS]{.underline}, 13: 919-925, 1999.

31\. Diwan B. A., Riggs, C.W., Logsdon, D., Haines, D.C., Olivero, O.A.,
Rice, J.M., Yuspa, S.H., Poirier, M.C and Anderson, L.M. Multiorgan
transplacental and neonatal carcinogenicity of
3\'-azido-3\'-deoxythymidine in mice. [Toxicology Applied
Pharmacology]{.underline} 15;161(1): 82-99, 1999.

32\. Sussman, H.E., Olivero, O.A., Pietras, S.M., Poirier, M.C.,
O'Neill, J. P., Finette, B.A. and Walker, V.E. Genotoxicity of
3\'-azido-3\'-deoxythymidine (AZT) in the human lymphoblastoid cell
line, TK6: relationship between DNA incorporation, mutant frequency, and
spectrum of deletions in HPRT. [Mutation Research]{.underline}.
429(2):249-259 1999.

33\. Poirier, M.C., Patterson, T. A., Slikker, W. Jr. and Olivero, O.
A.: Incorporation of 3\'-azido-3\'-deoxythymidine (AZT) into fetal DNA,
and fetal tissue distribution of drug, after infusion of pregnant
late-term rhesus macaques with a human-equivalent AZT dose. [J Acquired
Immune Def Synd and Hum Retrovirol]{.underline}. 22: 477-483, 1999.

34\. Meng, Q., Su, T., Olivero, O.A., Poirier, M.C., Shi, X., Ding, X.
and Walker, V.E.: Relationships between DNA incorporation, mutant
frequency, and loss of heterozygosity at the *TK* locus in human
lymphoblastoid cells exposed to 3\'-azido-3\'-deoxythymidine. [Tox
Sci]{.underline}. 54: 322-329, 2000.

35\. Bialkowska, A., Bialkowski, K.., Gerschenson, M., Diwan, B. A.,
Jones, A. B., Olivero, O. A., Poirier, M. C., Anderson, L. M., Kasprzak,
K. S. and Sipowicz, M. A.: Oxidative DNA damage in fetal tissues after
transplacental exposure to 3\'-azido-3\'-deoxythymidine (AZT).
[Carcinogenesis]{.underline} 21: 1059-1062, 2000.

36\. Slikker Jr., W., Olivero, O. A., Patterson, T. A. and Poirier, M.
C.: Potential toxicities of HIV therapeutics in the developing infant.
[Teratology]{.underline} 61: 397-398, 2000.

37\. Diwan, B. A., Olivero, O. A. and Poirier, M. C.: Absence of
structural or functional alterations in male and female reproductive
organs of F1 and F2 generations derived from female mice exposed to
3\'-azido-3\'-deoxythymidine during pregnancy. [Tox. Lett]{.underline}.
115: 9-15, 2000.

38\. Roth, M. J., Dawsey, S. M., Wang, G-Q., Tangrea, J. A., Zhou, B.,
Ratnasinghe, D., Woodson, K. G., Olivero, O. A., Poirier, M. C., Frye,
B. L., Taylor, P. R. and Weston, A.: Association between *GSTM1^\*^0*
and squamous dysplasia of the esophagus in the high risk region of
Linxian, China. [Cancer Lett]{.underline}. 156: 73-81, 2000.

39\. Olivero, O. A., Shearer, G. M., Chougnet, C. A., Kovacs, A. A. S.,
Baker, R., Stek, A. M., Khoury, M. M. and Poirier, M. C.: Incorporation
of zidovudine into cord blood DNA of infants and peripheral blood DNA of
their HIV-1-positive mothers. In: [Annals of the NewYork Academy of
Sciences]{.underline}, Ammann, A. (Ed.), 2000, Vol 918, page 262-269.

40\. Meng, Q., Walker, D. M., Olivero, O. A., Shi, X., Antiochos, B. B.,
Poirier, M.C. and Walker, V. E.: AZT-ddI coexposure potentiates DNA
incorporation of AZT and mutagenesis in human cells. [Proc. Natl. Acad.
Sci. USA]{.underline}, 97: (23) 12667-1267, 2000

41\. Tejera, A. M.., Alonso, D.F., Gomez, D.E. and Olivero, O.A.:
Chronic *in vitro* exposure to3'-azido-2', 3'-dideoxythymidine induces
senescence and apoptosis and reduces tumorigenicity of metastatic mouse
mammary tumor cells. [Breast Cancer Res Treat.]{.underline}, 65: (2)
93-9, 2001.

42\. Olivero, O.A., Reddy, M., Pietras, S.M. and Poirier, M.C. Plasma
drug levels compared to DNA incorporation of
3\'-azido-3\'-deoxythymidine (AZT) in adult Cynomolgus (*Macaca
fascicularis*) monkeys. [Experimental Biology and Medicine]{.underline},
226(5):446-449, 2001.

43\. Olivero, O.A., Fernandez, J.J., Antiochos, B.B., Wagner, J. L., St.
Claire, M.E. and Poirier, M.C.Transplacental genotoxicity of combined
antiretroviral therapy in *Erythrocebus patas* monkeys. [J Acquired
Immune Def Synd]{.underline}. 29:323‑329, 2002.

44\. van Gijssel, H.E., Divi, R.L, Olivero, O.A., Roth, M.J., Wang, G.Q,
Dawsey, S.M., Albert, P.S., Qiao, Y.L., Taylor, P.R., Dong, Z.W.,
Schrager,J.A., Kleiner, D.E. and Poirier, M.C.Semi-quantitation of
polycyclic aromatic hydrocarbon (PAH)-DNA adducts in human esophagus by
immunohistochemistry and the Automated Cellular Imaging System. [Cancer
Epidemiology Biomarkers and Prevention]{.underline},11:1622-1629, 2002.

45\. Poirier, M.C., Divi, R.L., Al-Harthi, L., Olivero, O.A., Nguyen,
V., Walker, B., Landay, A.L., Walker, V.E., Charurat, M., Blattner, W.A.
for the Women and Infants-Transmission Study (WITS) Group. Long-term
mitochondrial toxicity in HIV-uninfected infants born to HIV-infected
mothers. [J Acquired Immune Def . Synd]{.underline}. 33(2):175-183,
2003.

46\. Gerschenson, M., Nguyen, V., Ewings, E.L., Ceresa, A., Shaw, J.A.,
St. Claire, M..C., Nagashima, K., Harbaugh, S.W., Harbaugh, J.W.,
Olivero, O.A., and Poirier, M.C. Transplacental zidovudine and
lamivudine exposure induce fetal mitochondrial toxicity in an
*Erythrocebus patas* monkey model. [AIDS research and human
retroviruses]{.underline}, 20 (1): 91-100, 2004.

47\. Poirier, M.C., Olivero, O.A., Walker, D., and Walker, V.E.
Perinatal genotoxicity and carcinogenicity of the antiretroviral
nucleoside analog drugs. [Toxicology and Applied
Pharmacology]{.underline} 199 (2):151-161, 2004.

48\. Olivero, O.A., Tejera, A.M., Fernandez, J.J., Taylor B.J. Das, S.,
Divi, R.L. and Poirier, M.C. Genotoxicity and Cell Cycle Alterations in
Human Cells Exposed to Antiretroviral Nucleoside Analog Drugs.
[Mutagenesis]{.underline}, 20-139-146, 2005.

49\. Gwinn, M.R., Keshava, C., Olivero, O.A., Humsi, J.A., Poirier,
M.C., and Weston, A. Transcriptional Signatures of Normal Human Mammary
Epithelial Cells in Response to Benzo\[a\]pyrene Exposure: A Comparison
of Three Microarray Platforms. [BMC Omics]{.underline}. 9(4):334-350,
2005.

50\. Divi.R.L., Haverkos, K.J., Humsi, J.A., Nagashima, K., Olivero,
O.A., and Poirier, M.C.

> Chronic Zidovudine exposure in HeLa cells results in persistent
> mitochondrial alterations in morphology, DNA quantity, gene expression
> and function. \[E-publication ahead of print\], 2006.

51\. van Gijssel, H.E., Leil, T.A., Weinberg, W.C., Divi, R.L., Olivero,
O.A. and Poirier, M.C. Cisplatin-DNA damage in *p21^WAF1/Cip1^*
deficient mouse keratinocytes exposed to cisplatin.
[Mutagenesis]{.underline}. 22(1):49-54, 2007

52\. Olivero, O.A. Genotoxicity of Nucleoside Reverse Transcriptase
Inhibitors: An Overview. [Environmental and Molecular
Mutagenesis]{.underline} 48: 215-223, 2007.

53\. Torres, S.M., Walker, V.E., Carter, M.M., Cook, D.L., McCash, C.,
Olivero, O.A., Poirier, M.C. and Walker, D. M. Cytotoxicity and
Mutagenicity of Zidovudine, Lamivudine, and Abacavir Following Exposure
of Human Lymphoblastoid Cells to Single Agents or Drug Combinations.
[Environmental and Molecular Mutagenesis]{.underline} 48:224-238, 2007.

54\. Meng, Q., Olivero, O.A., Fasco, M.J., Bellisario, R., Kaminsky,
L.S., Pass, K.A., Abrams, E.J., Wade, N.A., Poirier, M.C., Walker, V.E.
and protocol team. Plasma and cellular markers of zidovudine metabolism
as indicators of DNA incorporation of zidovudine in cord blood
lymphocytes from infants exposed *in utero.* [Environmental and
Molecular Mutagenesis]{.underline} 48:307-321, 2007.

55. Escobar P.A., Olivero O. A., Poirier M.C., Bigbee W.L. and Walker
V.E., Correlation between DNA damage and AZT-DNA incorporation in an *in
vitro* model and in a cohort of new born exposed *in utero*.
[Environmental and Molecular Mutagenesis]{.underline} 48: 330-343, 2007.

> [Submitted]{.underline}

56\. Pratt, M.M., Sirajuddin, P., Poirier, M.C., Schiffman, M. Glass,
A.G., Scott, D.R., Rush, B.B., Olivero, O.A., and Castle, P.E. Number
range CHAPTERImmunohistochemical Semi-quantitation of Polycyclic
Aromatic Hydrocarbon (PAH)-DNA Adducts in Cervical Tissue from Women
Infected with Oncogenic Human Papillomaviruses (HPV).
[Carcinogenesis.]{.underline}

> 57\. Olivero, O.A. In vitro and in vivo genotoxicity of the nucleoside
> analog and antiviral agent AZT (azidothymidine). [(Mutation
> Research)]{.underline}

ABSTRACTS

1\. Olivero, O. A., Huitfeldt, H. S. and Poirier, M. C.: Chromosome
site-specific immunohistochemical detection of DNA adducts in
N-acetoxy-acetylaminofluorene-exposed CHO cells. [Proc. Am. Assoc.
Cancer Res]{.underline}., 1988.

2\. Olivero, O. A., Huitfeldt, H. S. and Poirier, M. C.: Chromosome-site
specific immunohistochemical detection of DNA-adducts in
N-acetoxy-acetylaminofluorene-exposed CHO cells. Gordon Conference on
Drug Metabolism, Plymouth, NH, 1988.

3\. Olivero, O. A., Huitfeldt, H. S. and Poirier, M. C.: Aplicacion de
tecnicas de inmunofluorescencia para la deteccion de aductos inducidos
por acetil aminofluoreno en celulas CHO. XIX Congreso Argentino de
Genetica, San Salvador de Jujuy, Argentina, 1988.

4\. Olivero, O. A., Huitfeldt, H. S. and Poirier, M. C.: Chromosome-site
specific immunohistochemical detection of DNA-adducts in
N-acetoxy-acetylaminofluorene-exposed CHO cells. NIH Research Day,
National Institutes of Health, Bethesda, MD, 1988.

5\. Olivero, O. A., Huitfeldt, H. S. and Poirier, M. C.: Chromosome
site-specific immunohistochemical detection of DNA adducts in
N-acetoxy-acetylaminofluorene-exposed cells. NIH Research Day, 1988.

6\. Olivero, O. A. and Poirier, M. C.: Consistent localization of DNA
adducts on metaphase chromosomal sites in CHO cells, and relationship of
adduct concentration to cell cycle phase at exposure. [Proc. Am. Assoc.
Cancer Res]{.underline}., 30: 131 (Abstract 516), 1989.

7\. Olivero, O. A. and Poirier, M. C.: Immunohistochemical localization
of DNA adducts formed during DNA replication. Fifth International
Conference on Environmental Mutagens, Cleveland, OH, July 10-15, 1989.

8\. Poirier, M. C. Olivero, O. A., Weston, A. and Beland, F. A.:
Multiple approaches to the investigation of aromatic amine-DNA
interactions utilizing adduct-specific antisera. Fifth International
Conference on Environmental Mutagens, Cleveland, OH, July 10-15, l989.

9\. Olivero, O. A., Semino, M.C. and Poirier, M. C.: Immunoelectron
microscopy of DNA-adducts induced by N-acetoxy-2-acetylaminofluorene
(N-AC-AAF) in Chinese hamster ovary (CHO) cells using colloidal gold.
[Proc. Am. Assoc. Cancer Res]{.underline}., 31: 88 (Abstract 520), 1990.

10.McGavran, L., Parker, N. B., Davila, C., Olivero, O. A. Poirier, M.
C. and Manchester, D. K.: Immunocytochemical detection of *in vitro*
induced chrysene-DNA adducts on human chromosomes. [Proc. Am. Assoc.
Cancer Res]{.underline}., 31: 98 (Abstract 580), 1990.

11.Olivero, O. A., Semino, C. and Poirier, M. C.: Immunoelectron
microscopy of DNA-adducts induced by N-acetoxy-2-acetylaminofluorene
(N-Ac-AAF) in Chinese Hamster Ovary cells using colloidal gold. [NIH
Research Day]{.underline}., 1990.

12.Olivero, O. A. and Poirier, M. C.: Cytotoxicity, DNA binding and
immunofluorescent localization of 3\'-azido-2\',3\'-dideoxythymidine
(AZT) in human, hamster and mouse cell lines. [Proc. Am. Assoc. Cancer
Res]{.underline}., 32: 96 (Abstract 574), 1991.

13.Olivero, O. A. and Poirier, M. C.: Cytotoxicity, DNA binding and
immunofluorescent localization of 3\'-azido-2\',3\'-dideoxythymidine
(AZT). [NIH Research Day]{.underline}, September 24, 1991.

14.Parker, N. B., McGavran, L., Poirier, M. C., Olivero, O. A.,
Cericevic, Z., Smith, L. C. and Manchester, D. K.: Computerized imaging
of carcinogen-DNA adducts on human metaphase chromosomes. Symposium on
Genomic Instability and Cancer, 20^th^ Annual Meeting of the Keystone
Symposia on Molecular and Cellular Biology, Tamarron, Colorado, February
4-10, 1991, [J. Cell. Biochem. Suppl]{.underline}., 15 (Part D), 1991.

15.McGavran, L., Parker, N. B., Olivero, O. A., Poirier, M. C. and
Manchester, D. K.: An immunocytogenetic *in vitro* model for the
detection of chrysene-DNA adducts on human-chromosomes. [Am. J. Hum.
Genetics]{.underline} 49: 245 (Suppl. S), 1991.

16.Olivero, O. A., Beland, F. A. and Poirier, M. C.: Incorporation of
3\'-azido-2\',3\'-dideoxythymidine (AZT) into the DNA of hamster and
mouse cell lines measured by radioimmunoassay. [Proc. Am. Assoc. Cancer
Res]{.underline}., 33: 171, 1992.

17.Olivero, O. A. and Poirier, M. C.: Z-DNA configuration in Chinese
Hamster Ovary cells as a preferential target for AZT incorporation.
[Proc. Am. Assoc. Cancer Res.]{.underline}, 33: 430 (Abstract 256),
1992.

18.Olivero, O. A., Beland, F. A. and Poirier, M. C.: Cytotoxicity,
DNA-binding and immunofluorescent localization of
3\'-azido-2\',3\'-dideoxythymidine (AZT) in human, hamster and mouse
cell lines. [In Vitro]{.underline}, 28: 137 (Abstract T-1022), 1992.

19.Olivero, O. A., Beland, F. A. and Poirier, M. C.: Cytotoxicity, DNA
binding and immunofluorescent localization of AZT in human, hamster and
mouse cell lines. [NIH Research Festival]{.underline}, Sept., 1992.

20.Olivero, O. A., Fullerton, N. F., Beland, F. A. and Poirier, M. C.:
DNA incorporation and the induction of chromosomal aberrations in mice
chronically administered 3\'-azido-2\',3\'-dideoxythymidine (AZT) in
drinking water. [Proc. Am. Assoc. Cancer Res]{.underline}., (Abstract
1564), 1993.

21.Olivero, O. A., Beland, F. A. and Poirier, M. C.: Incorporation of
AZT into DNA and chromosomal aberrations in mice chronically exposed to
AZT in the drinking water. [NIH Research Festival]{.underline}, Sept.,
1993.

22.Olivero, O. A., Fullerton, N. F., Beland, F. A. and Poirier, M. C.:
Incorporation of 3\'-azido-2\',3\'-dideoxythymidine (AZT) into vaginal
DNA of CD-1 mice correlates with epithelial proliferation and an
increase in á6 integrin. [Proc. Am. Assoc. Cancer Res]{.underline}.,
(Abstract 2025), 1994.

23.Olivero, O. A., Semino, M. C., Kassim, A., Lopez Larraza, D. M. and
Poirier, M. C.: Preferential binding of cisplatin to mitochondrial DNA
of Chinese Hamster Ovary (CHO) cells using dissociation enhanced
lanthanide fluoroimmunoassay (DELFIA). [Proc. Am. Assoc. Cancer
Res]{.underline}., (Abstract 641), 1994.

24.Olivero, O. A., Gomez, D. E., Kassim, A. and Windle, B. E.:
Preferential incorporation of 3\'-azido-2\',3\'-dideoxythymidine (AZT)
into telomeric DNA of chinese hamster ovary (CHO) cells. [Proc. Am.
Assoc. Cancer Res]{.underline}., (Abstract 2024), 1994.

25.Agarwal, R. P. and Olivero, O. A.: Chromosomal aberrations in *in
vitro* chronically exposed cells to 3\'azido-2\'-3\'-dideoxythymidine
(AZT). [Proc. Am. Assoc. Cancer Res]{.underline}, (Abstract 1847), 1994.

26.Olivero, O. A., Gomez, D. E., Kassim, A. and Windle, B. E.: Telomeric
DNA of CHO cells is a preferential target for AZT
(3\'-azido-2\',3\'-dideoxythymidine) incorporation. [NIH Research
Festival]{.underline}. Sept., 1994.

27.Olivero, O. A., Semino, M. C., Kassim, A., Lopez Larraza, D. M. and
Poirier, M. C.: Preferential binding of cisplatin to mitochondrial DNA
of chinese hamster ovary (CHO) cells using dissociation enhanced
lanthanide fluoroimmunoassay (DELFIA). [11th Congreso Latinoamericano de
Genetica]{.underline}, Puerto Vallarta, Mexico, Sept., 1994.

28.Olivero, O. A., Gomez, D. E., Kassim, A. and Windle, B. E.:
Preferential incorporation of AZT in telomeric DNA of Chinese hamster
ovary cells. [11th Congreso Latinoamericano de Genetica]{.underline},
Puerto Vallarta, Mexico, Sept., 1994.

29.Olivero, O. A.: Immunolocalization. [11th Congreso Latinoamericano de
Genetica]{.underline}, Puerto Vallarta, Mexico, Sept., 1994.

30.Olivero, O. A.: Fluorescent *in situ* hybridization (FISH). [11th
Congreso Latinoamericano de Genetica]{.underline}, Puerto Vallarta,
Mexico, Sept., 1994.

31.Olivero, O. A., Chang, P. K., Lopez Larraza, D. M. and Poirier, M.
C.: Binding and removal of cisplatin in mitochondrial and genomic DNA of
Chinese hamster ovary (CHO) cells using a cisplatin-DNA dissociation
enhanced lanthanide fluoroimmunoassay (DELFIA). [Proc. Am. Assoc. Cancer
Res]{.underline}., (Abstract 851), 1995.

32.Olivero, O. A., Fullerton, N. F., Beland, F. A. and Poirier, M. C.:
3\'-Azido-2\',3\'-dideoxythymidine (AZT) preferentially incorporates
into liver mitochondrial DNA of CD-1 mice dosed with AZT in drinking
water for 28 days. [Proc. Am. Assoc. Cancer Res]{.underline}., (Abstract
2113), 1995.

33.Olivero, O.A., Gomez, D.E., Kassim, A. and Windle, B.E.: Telomeric
DNA of CHO cells as a target for AZT
(3\'-azido-2\',3\'-dideoxythymidine) incorporation through telomerase.
[Proc. Am. Assoc. Cancer Res]{.underline}., (Abstract 3312), 1995.

34.Olivero, O. A., Gomez, D. E., Kassim, A., Maine, I. P., Chen, S. F.
and Windle, B. E.: Is AZT a possible anti-telomerase drug? [Mol. Biol.
Cancer]{.underline}., 1995.

35.Giurgiovich, A. J., Diwan, B. A., Olivero, O. A., Anderson, L. M. and
Poirier, M. C.: Tumorigenic levels of cisplatin induce rat fetal
mitochondrial and genomic DNA adducts after prenatal exposure. [NIH
Research Festival]{.underline}, September, 1995.

36.Olivero, O. A., Gomez, D., Kassim, A. and Windle, B.: Telomeric DNA
of CHO cells is a target for AZT (3\'-Azido-2\',3\'-dideoxythymidine)
incorporation, possibly through telomerase. [NIH Research
Festival]{.underline}, September, 1995.

37.Olivero, O. A. And Gomez, D. E.: Telomeres as a target for cancer
therapy. [Cancer: The Interface Between Basic and Applied
Research]{.underline}, Baltimore, MD, 1995.

38.Olivero, O.A., Chang, P., Lopez‑Larraza, D.M., Semino, M.C. and
Poirier, M.C.: Preferential binding and lack of removal of cisplatin in
mitochondrial DNA of Chinese hamster ovary cells measured by
dissociation enhanced lanthanide fluroimmunoassay (DELFIA) and electron
microscopy. [The American Society for]{.underline} [Cell
Biology]{.underline}, December, 1995.

39.Giurgiovich, A.J., Anderson, L.M., Jones A.B., Dove, L.F., Moskal,
T.J., Rice, J.M., Olivero, O.A. and Poirier, M.C.: Transplacental
cisplatin exposure induces fetal DNA damage in Patas monkey. [EMS
Meeting]{.underline}, 1996.

40.Olivero, O.A., Chang, P., Lopez‑Larraza, D.M., Semino, M.C. and
Poirier, M.C.: Mitochondrial DNA of Chinese hamster ovary cells is a
target for the chemotherapeutic agent cisplatin. [EMS
Meeting]{.underline}, 1996.

41.Giurgiovich, A.J., Diwan, B. A., Olivero, O.A., Anderson, L.M., Rice,
T. J. and Poirier, M.C.: Cisplatin genomic and mitochondrial DNA adduct
formation in pregnant rats and their transplacentally-exposed fetuses.
[Proc. Am. Assoc. Cancer Res]{.underline}., (Abstract 2485), 1996.

42.Gomez, D. E. And Olivero, O. A.: Long-term AZT
(3\'-Azido-2\',3\'-dideoxythymidine) treatment shortens the telomeric
sequences of HeLa cells in culture. [Proc. Am. Assoc. Cancer
Res]{.underline}., (Abstract 3848), 1996.

43.Olivero, O.A., Gomez, D.E., and Poirier, M.C. Telomere shortening by
long-term and transplacental AZT (3\'-Azido-2\',3\'-dideoxythymidine)
exposure. [NIH Research Festival. September, 1996.]{.underline}

44.Giurgiovich, A., Diwan, B., Olivero, O. A., Anderson, L. M., Rice, J.
M. and Poirier, M. C.: Transplacental cisplatin exposure and DNA adduct
formation in two animal species. [VI World Conference on Clinical
Pharmacology and Therapeutics, Argentina]{.underline}, 1996.

45.Olivero, O.A., Gomez, D.E., and Poirier, M.C. Telomere shortening by
long-term and transplacental AZT (3\'-Azido-2\',3\'-dideoxythymidine)
treatment. [Cancer Prevention and Detection 20(5) (Abstract 038),
1996.]{.underline}

46.Olivero.O.A. Diwan, B.A., Anderson, L. M., Rice, J. M., Beland, F.A.,
Yuspa, S.H. and Poirier, M. C. AZT is a genotoxic transplacental
carcinogen in mice. [NCI combined Intramural Principal Investigator
Retreat, November, 1996.]{.underline}

47.Olivero, O.A., Anderson, L. M., Diwan, B., Rice, J. M., Yuspa, S.H.,
Laing, C.P., Chang, P.K., Jones, A. B. and Poirier, M. C. Transplacental
incorporation of 3\'-Azido-2\',3\'-dideoxythymidine into DNA of fetal
CD-1 mice and *Erythrocebus patas* monkeys.[Proc. Am. Assoc. Cancer
Res]{.underline}.,(Abstract 3110, pg 465), 1997.

48.Sipowicz, M.A., Diwan, B., Olivero, O.A., Poirier, M. C., Anderson,
L. M., and Kasprzak, K.S. Oxidative DNA damage in mouse and monkey
fetuses after transplacental exposure to
3\'-Azido-2\',3\'-dideoxythymidine (AZT). [Proc. Am. Assoc. Cancer
Res]{.underline}., (Abstract 2372, pg 354), 1997.

49.Olivero, O.A., Anderson, L. M, Diwan, B., Haines, D.C., Riggs, C.V.,
Moskal, T.J., Jones, A.B., Rice, J.M., Yuspa, S.H. and Poirier, M.C. AZT
is a genotoxic transplacental carcinogen in animal models. [J. of
Acquired Immunodeficiency Syndromes and Human Retrovirology. 14(4): 29.
Abstract 52, 1997.]{.underline}

50.Zhang, Z., Olivero, O.A., Anderson, L. M, Diwan, B., Haines, D.C.,
Rice, J.M., Yuspa, S.H. and Poirier, M.C. Ras gene analysis in liver and
lung tumors from adult mice given transplacental exposure to
3\'-Azido-2\',3\'-dideoxythymidine (AZT). [Genetic Toxicology, Gordon
Conference 1997.]{.underline}

51.Walker, V.E., Olivero, O.A., Sussman, H.E, and Poirier, M.C.
Genotoxicity of transplacental AZT therapy in children and rodent
models. [Genetic Toxicology, Gordon Conference 1997.]{.underline}

52.Olivero, O.A., Anderson, L. M, Diwan, B., Haines, D.C., Moskal, T.J.,
Jones, A.B. Rice, J.M., Riggs, C.V., Shearer, G.M., Chougnet, C.A.,
Kovacs, A., Yuspa, S.H. and Poirier, M.C. Transplacental genotoxicity of
3\'-Azido-2\',3\'-dideoxythymidine (AZT) in mice, monkeys and humans,
and transplacental tumorigenicity in mice. [Institute of Human Virology
Annual Meeting, 1997.]{.underline}

53.Olivero, O.A., Anderson, L. M, Diwan, B., Haines, D.C., Rice, J.M.,
Shearer, G.M., Chougnet, C.A., Kovacs, A., Yuspa, S.H. and Poirier, M.C.
AZT is a potential transplacental carcinogen. [Conference on Global
Strategies for the Prevention of HIV Transmission from Mothers to
Infants, 1997.]{.underline}

54.Damo, L., Olivero, O.A., and Poirier, M.C. Relationship between AZT
induced genotoxicity and suppression of apoptosis in mouse skin.
[National Minority Research Symposium, 1997.]{.underline}

55.Olivero, O.A., Anderson, L.M., Diwan, B.A., Haines, D.C., Rice,
J.M.,Riggs, C.V.,Logsdon, D., Yuspa, S.H. and Poirier, M.C.
Tumorigenicity and Genotoxicity of 3\'-Azido-2\',3\'-dideoxythymidine
(AZT) in mice exposed in utero. [NIH Research Festival, Bethesda,
1997]{.underline}.

56.Olivero, O.A., Pirilä, R., Vähäkangas, K., and Poirier, M.C.
Placental transfer and incorporation of AZT (3\'-azido-2\',3\'-dideoxy-
thymidine) into placental DNA in a human AZT perfusion model. [Proc. Am.
Assoc. Cancer Res]{.underline}., (Abstract 4292, pg 631), 1998.

57.Olivero, O. A., Shearer, G.M., Chougnet, C., Kovacs, A., Patterson,
T. A., Binienda, Z. K., Slikker, W. and Poirier, M.C.
3\'-Azido-3\'-deoxythymidine (AZT) pharmacokinetics and AZT-DNA
incorporation in pregnant monkeys and humans. [Proc. Am. Assoc. Cancer
Res]{.underline}., (Abstract 4291, pg 631), 1998.

58.Zhang, Z., Olivero, O. A., Quan, H., Anderson, L.M., Diwan, B.A.,
Haines, D.C., Rice, J.M. Yuspa, S.H. and Poirier, M.C. Ras gene analysis
in liver, lung and skin tumors from adult mice given transplacental
exposure to 3\'-Azido-3\'-deoxythymidine (AZT). [Proc. Am. Assoc. Cancer
Res]{.underline}., (Abstract 4288, pg 631) 1998.

59.Diwan, B.A., Olivero, O.A., Haines, D.C., Rice, J.M., Yuspa, S.H.,
Poirier, M.C. and Anderson, L.M. Transplacental carcinogenicity of AZT
mice. [Proc. Am. Assoc. Cancer Res]{.underline}., (Abstract 143, pg 21),
1998.

60.Olivero, O. A., Anderson, L.M., Diwan, B.A., Haines, D.C., Rice,
J.M., Riggs, C.W., Yuspa, S.H. and Poirier, M.C. Transplacental effects
of AZT (3\'-azido-2\',3\'-dideoxy- thymidine). [Environmental and
Molecular Mutagenesis]{.underline} 31 supl. 29 (Abstract P 100, pg 52),
1998.

61.Olivero, O. A., Chougnet, C., Shearer, G.M., Kovacs, A., and Poirier,
M.C. AZT, a genotoxic transplacental carcinogen in rodents, is
incorporated into human fetal and maternal DNA. [J. of Acquired
Immunodeficiency Syndromes and Human Retrovirology.]{.underline} 17(4)
(Abstract 8, pg A13), 1998.

62.Poirier, M.C., Anderson, L.M., Shamkhani, H., Giurgiovich, A.J, Rice,
J.M., Shearer, G.M., Chougnet, C.A., Kovacs, A., and Olivero, O.A.
Transplacental Genotoxicity in animal models and humans. [Third world
Congress on Advances in Oncology]{.underline}, Crete, Greece October,
1998

63.Olivero, O.A., Pirilä, R., Vähäkangas, K., Shearer, G.M., Chougnet,
C.A., Kovacs, A., and Poirier, M.C. AZT-DNA incorporation in
human-mother infant pairs and in a human placental perfusion model.
[Annual Meeting Institute of Human Virology]{.underline}, Baltimore, MD
August, 1998.

64.Olivero, O. A., Pirilä, R., Vähäkangas, K., Shearer, G.M. Chougnet,
C., Kovacs, A.., and Poirier, M.C. AZT, a genotoxic transplacental
carcinogen in rodents is genotoxic in humans. [The third International
Conference on environmental mutagens in human populations]{.underline},
Thailand, Nov-Dec, 1998.

65.Olivero, O.A., Pirilä, R., Vähäkangas, K., Shearer, G.M., Chougnet,
C.A., Kovacs, A., and Poirier, M.C. AZT-DNA incorporation in
human-mother infant pairs and in a human placental perfusion model.
[Annual Meeting Institute of Human Virology]{.underline}, Baltimore, MD
August, 1998.

66.Slikker, W., Olivero, O. A., Patterson, T. A., and Poirier, M.C.
Potential toxicities of HIV therapeutics in the developing infant.
[Annual Meeting of Teratology]{.underline}. June 1999.

67.Olivero, O.A., Chougnet, C.A., Kovacs, A.S., Pirilä, R., Vähäkangas,
K., Shearer, G.M., and Poirier, M.C. Incorporation of AZT into blood
cell DNA of mothers and infants at delivery and normal placentas exposed
*ex vivo.* [Environmental and Molecular Mutagenesis]{.underline} 33
supl. 30 (Abstract 155, pg 48), 1999.

68.Sussman, H.E., Olivero, O.A., Pietras, S.M., Poirier, M.C., O\'Neill,
J.P., Finette, B.A., and Walker V.E. Genotoxicity of
3\'-Azido-3\'-deoxythymidine (AZT) in the Human Lymphoblastoid Cell
Line, TK6. [Environmental and Molecular Mutagenesis]{.underline} 33
supl. 30 (Abstract 213, pg 63), 1999.

69.Olivero, O.A., Chougnet, Kovacs, A.S., Landay, Shearer, G.M., and
Poirier, M.C. Incorporation of 3\'-Azido-3\'-deoxythymidine (AZT) into
peripheral blood DNA of HIV-1 positive adults and cord blood DNA of
infants. [Proc. Am. Assoc. Cancer Res]{.underline}., (Abstract 2720, pg
411) 1999.

70.Olivero, O.A., Shearer, G.M., Chougnet C.A., Landay, A.L., Proia,
L.A., Kessler, H.A., Sha, B.E., Tarone, R.E. and Poirier, M. AZT becomes
incorporated into peripheral blood mononuclear cell-DNA of HIV-1
positive adults. [J. of Acquired Immunodeficiency Syndromes and Human
Retrovirology,]{.underline} 7(1):Abstract 26, pg A16, 1999.

71.Olivero, O.A., Shearer, G.M., Chougnet, C.A., Kovacs, A.S., Baker,
R., Stek, A.M., Khoury, M.M., Tarone, R.E. and Poirier, M.C.
Genotoxicity of transplacental AZT exposure in infants of HIV-1-positive
women. [The Second Conference for the prevention of HIV transmission
from mothers to infants]{.underline}, Montréal, Canada, 1999.

72.Olivero, O.A.; Shearer, G.M.; Chougnet, C.A.; Landay, A.L.; Proia,
L.A.; Kessler, H.A.; Sha, B.E.; Tarone, R.E. and Poirier, M.C.
Incorporation of AZT into peripheral blood mononuclear cell-DNA of HIV-1
positive adults. [NIH Research Festival, Bethesda, 1999.]{.underline}

73.Olivero, O.A., Reddy, M., Pietras, S.M. and Poirier, M.C.
Pharmacokinetics and genotoxicity of 3\'-azido-3\'-deoxythymidine (AZT)
in Cynomolgus (*Macaca fascicularis*) monkeys. [Environmental and
Molecular Mutagenesis]{.underline}, 2000.

74.van Gijssel, H.E., Roth, M.J., Divi, R.L., Olivero, O.A., Dawsey,
S.,Taylor, P.R., and Poirier, M.C. Polycyclic aromatic hydrocarbon
(PAH)-DNA adducts in human esophageal tissue by automated cellular
imaging. [Molecular Epidemiology: A new tool for Cancer Prevention.
Keyston Conference. Taos, 2000]{.underline}.

75.Meng, Q., Su, T., Olivero, O.A., Poirier, M.C., Shi, X., Ding, X. and
Walker, V.E.: Relationships between DNA incorporation, mutant frequency,
and loss of heterozygosity at the *TK* locus in human lymphoblastoid
cells exposed to AZT. [Proceedings of the American Association for
Cancer Research]{.underline}, 41: 69 (Abstract 441), San Francisco, CA,
April, 2000.

76.Zhang, Z., Diwan, B., Olivero, O.A., Anderson, L.M., Yuspa, Y.H. and
Poirier, M.C.: Skin tumorigenesis and H-*ras* and K-*ras* mutations in
skin tumors from adult mice exposed *in utero* to
3\'-azido-2,3\'-dideoxythymine (AZT). [Life Science and Clinical
Medicine 2000]{.underline}, Beijing, China, April, 2000.

77.Meng, Q., Su, T., Olivero, O. A., Shi, X., Poirier, M. C., Ding, X.
and Walker, V.: Relationship between DNA incorporation of AZT and
synergistic effects of AZT and ddI in inducing *HRPT* and *TK* mutations
in human cells. [Environmental and Molecular Mutagenesis]{.underline},
2000.

78.Walker, V. E., Wade, N., Abrams, E., Meng, Q., Olivero, O., Poirier,
M.C., O'Neil, J., Bigbee, W. and Ness, R.: Biomarkers of exposure and
effect as indicators of genotoxicity and mutagenicity arising from
antiretroviral chemoprophylaxis in children of HIV-infected women.
[Pediatric Academy of Sciences, Joint Meeting: Advancing Children's
Health]{.underline}. Boston, MA. May, 2000.

79.van Gijssel, H.E., Roth, M.J., Divi, R.L.,Olivero, O.A., Dawsey,
S.M., Taylor, P.R., Schrager, J.A., Kleiner, D.E. and Poirier, M.C.: Is
the high rate of esophageal cancer in Linxian, China associated with the
formation of PAH-DNA adducts in human esophageal tissue? [NIH Research
Festival]{.underline}. Bethesda, MD. October 2000.

80.Olivero, O.A., Fernandez, J.J., Antiochos, B.B., Wagner, J. L. and
Poirier M.C.: Transplacental genotoxicity of the nucleoside analogs AZT
and 3TC in the *Erythrocebus patas* monkey model. [NIH Research
Festival]{.underline}. Bethesda, MD. October 2000.

81.Slikker, W. Jr., Churchwell, M.I., Fang, J-L, Olivero, O.A.,
Patterson, T.A., Beland, F.A., Poirier, M.C. and Doerge, D.R.:
Assessment for potential toxicities of HIV therapeutics in the
developing infant. [Rochester Trophoblast Conference
Symposium]{.underline}. Rochester, NY. October 2000.

82.Olivero, O.A., Fernandez, J.J., Antiochos, B.B., Wagner, J. L. and
Poirier, M.C.: Fetal DNA damage following transplacental nucleoside
analogs reverse transcriptase inhibitors (NRTI) exposures in humans and
experimental animal models. [Environmental and Molecular
Mutagenesis]{.underline}:37, Supplement 32 pg. 59. Abstract 162, 2001.

83.Escobar, P.A., Olivero, O.A., Day, B.W., Tice, R.R., Romkes, M., Day,
R.D. and Bigbee, W.L.: AZT-induced DNA damage detected by the comet
assay. [Environmental and Molecular Mutagenesis]{.underline}: 37,
Supplement 32 pg. 30. Abstract 51, 2001.

84.Poirier, MC., Gerschenson, M., Nguyen, V.T, Divi, R.L., Olivero,
O.A., Sable, C., St Claire, M.C., Tardieu, M., Rustin, P. and Blanche,
S.: Nucleoside analog-induced mitochondrial toxicity: Manifestations in
the clinic and in a transplacental *Erythrocebus patas* monkey model.
[Environmental and Molecular Mutagenesis]{.underline}: 37, Supplement 32
pg. 60. Abstract 167, 2001.

85.van Gijssel, H.E., Roth, M.J., Divi, R.L.,Olivero, O.A., Dawsey,
S.M., Taylor, P.R., Schrager, J.A., Kleiner, D.E. and Poirier, M.C.: Is
the high rate of esophageal cancer in Linxian, China associated with the
formation of PAH-DNA adducts in human esophageal tissue? [Environmental
and Molecular Mutagenesis]{.underline}: 37, Supplement 32 pg. 76.
Abstract 230, 2001.

86.Olivero, O.A., Fernandez, J.J., Antiochos, B.B., Wagner, J. L. and
Poirier, M.C. Nucleoside Analog Reverse Transcriptase Inhibitors (NRTIs)
Induce Fetal Genotoxicity in a Transplacental Primate Model. [5th
International AIDS Malignancy Conference]{.underline}, Bethesda, MD.
April, 23-25, 2001.

87.Escobar, P.A., Tice, R.R., Day, Romkes, M.., Day, B.W., Olivero,
O.A.Walker, V.E. and Bigbee, W.L.: Genotoxic impact in human newborns of
maternal exposures and lifestyles factors during pregnancy.
[International Comet Assay Workshop]{.underline}, Ulm Germany, July
2001.

88.Olivero, O.A., Tejera, A.M. , Fernandez J.J., Walker B.L and Poirier,
M..C. Genotoxicity of antiretroviral nucleoside analog drug
combinations. 8^th^ International Conference on Environmental Mutagens..
[Mutation Research]{.underline} 483: S130, O10-5. Shizuoka, Japan.
October 2001.

89.Poirier, M.C., Nguyen, V.T, Divi, R.L., Olivero, O.A., Sable, C., St.
Claire, M. C. and Gerschenson, M. Fetal mitochondrial toxicity induced
by human-equivalent doses of antiretroviral nucleoside analog drugs in a
transplacental *Erythrocebus patas* monkey model. 8 ^th^ International
Conference on Environmental Mutagens. [Mutation Research]{.underline}
483: S130, O10-6, Shizuoka, Japan. October 2001.

90.Poirier, M.C., Olivero, O.A., Bigbee, W., O'Neill, J.P. Meng, Q. and
Walker, V.E. [Transplacental Genotoxicity of Antiretroviral Nucleoside
Analog Drugs]{.underline}. Aspen CO, July 2001.

91.Olivero, O.A., Blattner, W.A., Landay, A.L., and Poirier, M.C.
Telomere shortening induced by transplacental nucleoside analog exposure
in primates. 2001 [International Meeting of the Institute of Human
Virology]{.underline}. Baltimore, MD, September 2001.

92.Olivero, O.A., Blattner, W.A., Landay, A.L., and Poirier, M.C.
Genotoxicity of antiretroviral nucleoside analogs in primates. [NIH-HEO
Second Annual Hispanic Scientist Day]{.underline}. NIH, Bethesda, MD,
October, 2001.

93.van Gijssel, H.E. Weinberg, W. C., Divi, R. L., Olivero, O. A., and
Poirier, M.C.The effect of p21*^waf/cip1^* on proliferation, apoptosis,
DNA adduct formation and DNA repair in mouse keratinocytes exposed to
*Cis*-diamminedichloroplatinum-II (CDDP).[Environmental and Molecular
Mutagenesis]{.underline}. 39: 64 (Abstract 208), 2002.

94\. Olivero, O.A., Tejera, A.M., Fernandez, J.J. and Poirier, M.C.
Genotoxicity of antiretroviral nucleoside analog drug combinations.
[Environmental and Molecular Mutagenesis]{.underline}. 39: 48 (Abstract
143), 2002.

95.Olivero, O.A., Kim, Y., Humsi, J. A. and Poirier, M.C. Quantitation
of telomeric DNA damage by long term nucleoside analog exposure.
[Environmental and Molecular Mutagenesis]{.underline}. 39: 48 (Abstract
142), 2002.

96.Escobar, P.A., Tice, R.R., Day, R.D., Romkes, M., Day, B.W., Olivero,
O.A., Walker, V.E. and Bigbee, W.L. Genotoxic Impact in Human Newborns
of Maternal Exposures and Lifestyle Factors During Pregnancy.
[Proceedings of the American Association for Cancer
Research]{.underline}, Abstract# 272, 54, 2002.

97.Olivero, O.A., Blattner, W.A., Landay, A.L. St. Claire, M., Poirier,
M.C.Genotoxicity of Transplacental Nucleoside Analogs (NA) in Primates.
[Proceedings of the American Association for Cancer
Research]{.underline}, Abstract \# 4267, 861, 2002

98.Olivero, O.A , Meng, Q, Humsi, J.A .Walker, V.E. and Poirier, M.C .
Incorporation of the nucleoside analogs (NA) AZT and 3TC into cord
blood-DNA from infants of HIV-1-infected mothers taking Combivir. [6 th
International AIDS Malignancy Conference]{.underline}. Bethesda, MD.
April, 22-24, 2002.

99.Olivero, O.A , Meng, Q, Humsi, J.A .Walker, V.E. and Poirier, M.C. We
know the benefits of the antiretroviral drugs, AZT and 3TC for HIV-1
infected patients, but do these drugs have genotoxic effects?
[Postbaccalaureate Poster Day 2002]{.underline}, National Institutes of
Health. Bethesda, MD.

100.Voris, J., Landay, A., Poirier, M.C. Olivero, O.A. and Al-Harthi L.
Maternal HIV status, and Not in utero AZT exposure, impacts thymic
function in HIV-seronegative infants of HIV infected mothers in the
first two years of life. [31st Annual Autumn Immunology
Conference]{.underline}, Chicago, November 2002.

101.Olivero, O.A., Tejera, A.M., Fernandez, J.J. and Poirier, M.C.
Consequences of AIDS antiretroviral therapy. [NIH Hispanic Scientist
Day]{.underline}. October, 2002. NIH, Bethesda, MD.

102.O.A. Olivero, J.A. Humsi, K.J. Haverkos., R. L. Divi and M.C.
Poirier. Microarray analysis of AZT-induced gene expression in cultured
human cells. [Molecular and Genetic Epidemiology of Cancer]{.underline},
Waikoloa, Hawaii, January, 2003.

103.Poirier, M.C., Divi, R.L., Olivero, O.A., Roth, M.J., Dawsey, S.M.
Albert, P.S., Taylor, P.R. Qiao, Y and van Gijssel, H.E. Validation of
Immunohistochemistry, by Immunoassay, for Determination of DNA Adducts
in Human Tissues. [Molecular and Genetic Epidemiology of
Cancer]{.underline}, Waikoloa, Hawaii, January, 2003.

104.Torres, S. Walker, V.E., Long, L., Olivero,O.A, Poirier, M.C. and
Walker, D.M. Mutagenicity of AZT, 3TC, and AZT‑3TC at the HPRT and TK
Loci of Human Lymphoblastoid Cells, TK6. [Molecular and Genetic
Epidemiology of Cancer]{.underline}, Waikoloa, Hawaii, January, 2003.

105.Walker, D, Olivero, O.A. Long, L, Poirier, M.C. and Walker, V.E. The
Aminothiol WR-1065 Protects Human Lymphoblastoid Cells from the
Synergistic Mutagenic Effects of Coexposure to Zidovudine and
Didanosine. [Molecular and Genetic Epidemiology of Cancer]{.underline},
Waikoloa, Hawaii, January, 2003.

106.Haverkos, K.J., Olivero, O.A. Humsi, J.A, Nagashima, K. Poirier, M.C
and Divi, R.L. Chronic exposure of HeLa cells to zidovudine
(3\'‑azido‑3\'‑dideoxythymidine, AZT) results in persistent
mitochondrial alterations in DNA quantity, gene expression, morphology
and function. [Environmental and Molecular Mutagenesis]{.underline}, 41:
178, 2003.

107.Olivero, O.A., Das, S., Whipkey, D.L., Weston, A. and Poirier, M.C.
Variability in interindividual genotoxic response in normal human
mammary epithelial (NHME) cells exposed to zidovudine. [Environmental
and Molecular Mutagenesis]{.underline}, 41: 196, 2003.

108.Olivero, O.A., Das, S., Weston, A. and Poirier, M.C. Genomic
instability and genotoxic response in human mammary epithelial cells
exposed to zidovudine .[Postbaccalaureate Poster Day 2003]{.underline},
National Institutes of Health. Bethesda, MD.

109\. Torres, S., Walker, V.E., Poirier, M.C., Olivero, O.A., Cook A.,
Ontiveros, J., Ming, J. and Carter, M.. Mutagenicity of AZT, 3TC and
AZT-3TC at the HPRT and TK genes of TK6 human lymphoblastoid cells.
[SACNAS National Conference]{.underline}. Albuquerque, NM, 2003.

110\. Olivero, O.A..,Humsi, J.A., Haverkos, K.J., Divi, R. L. and
Poirier, M.C. Microarray analysis of AZT-induced gene expression in
cultured human cells. [Fourth NIH Hispanic Scientist Day]{.underline},
NIH Bethesda, MD, 2003.

111\. Olivero, O.A., Tejera, A.M., Fernandez, J.J., Taylor B.J. Das, S.
and Poirier, M.C. Microarray and Biomarker Analysis of Cell Cycle
Changes in Human Cells Exposed to Antiretroviral Nucleoside Analogs.
[Keystone Meeting.]{.underline} Albuquerque, New Mexico. January 2004.

112\. Olivero, O.A., Tejera, A.M., Fernandez, J.J., Taylor B.J. Das, S.
and Poirier, M.C. The genotoxicity of antiretroviral nucleoside analog
drug combinations in human lymphoblastoid cells. [7 ^th^ International
Symposium on Molecular Basis of Predictive Oncology Intervention &
Strategies]{.underline}. Nice, France February, 2004.

113\. Walker, V.E., Walker, D.M., Campen, M.J., Divi, R.D. Olivero, O.A,
and Poirier, M.C. Mitochondrial and cardiovascular pathology in mice
exposed transplacentally to zidovudine (AZT) alone or with lamivudine
(3TC). [Annual Meeting Society of Toxicology]{.underline}, Baltimore MD,
2004

114.Olivero, O., Tejera, A.M., Fernandez, J.J., Taylor, B.J., Das, S.
and Poirier, M.C. Genetic profiling and induced genotoxicity of the
nucleoside analogs AZT and 3TC in human cells: cell cycle disturbances.
[American Association for Cancer Research]{.underline}. Orlando, FL,
2004.

115\. Torres S, Walker VE, Carter M, Cook D, Olivero OA, Poirier MC,
Walker DM. Relationship between Exposure Concentration, Duration, and
Mutagenicity Following Treatment of Human Lymphoblastoid TK6 Cells to
AZT, 3TC, and AZT-3TC. [2004 Conference Proceedings, University of New
Mexico Biomedical Sciences Graduate Program, Student Research
Day.]{.underline} (2004)

116\. Torres S, Olivero OA, Walker VE, Carter M, Cook D, Poirier MC,
Walker DM. Relationships Between Exposure Concentration, Duration and
Mutagenic Effect in Human Lymphoblastoid TK6 Cells Treated with AZT,
3TC, and AZT-3TC. [8^th^ International Conference on Malignancies in
AIDS and Other Immunodeficiencies . Bethesda, MD, 2004]{.underline}

117\. Olivero, O.A.; Vazquez, I.L; and Poirier, M.C. Metabolism of AZT
in human cells is altered during chronic exposure. [Annual Meeting of
the Society for Experimental Biology and Medicine. Washington DC,
2004.]{.underline}

118\. Divi, R.L. Haverkos, K.J. Olivero, O.A., Humsi, J.A., Nagashima,
K. and Poirier, M.C. Zidovudine exposure results in persistent
compensatory mitochondrial alterations in morphology, DNA quantity, gene
expression, and function in human tumor cells. [UMDF Meeting Pittsburgh,
PA, 2004.]{.underline}

119 Vazquez, I.L., Olivero, O.A., and Poirier, M.C. Altered AZT
metabolism may induce cellular drug resistance in human cells.
[Environmental and Molecular Mutagenesis]{.underline} 44(3):234. 2004.

120\. Olivero, O.A., Tejera, Das, S., Divi R.L., and Poirier, M.C.
Genotoxicity and cell cycle expression changes induced by nucleoside
reverse transcriptase inhibitors (NRTIs). [Environmental and Molecular
Mutagenesis]{.underline} 44(3):219. 2004.

121\. Torres, S., Walker, V.E., Olivero, O.A., Carter, M., Cook, D.,
Poirier MC, Walker, D.M. Relationships Between Exposure Concentration,
Duration and Mutagenic Effects in Human Lymphoblastoid TK6 Cells Treated
with AZT, 3TC, and AZT-3TC. [Environmental and Molecular
Mutagenesis]{.underline} 44(3):232. 2004.

122\. Pratt, M.M., Castle, P.E., Schiffman, M., Glass, A.G., Scott,
D.R., Rush, B.B., Olivero, O.A., and Poirier, M.C. Semi-quantitation of
polycyclic aromatic hydrocarbon (PAH-)-DNA adducts in human cervix by
immunohistochemistry and the automated cellular imaging system.
[Environmental and Molecular Mutagenesis]{.underline} 44(3):221. 2004.

123\. Vazquez, I.L., Olivero, O.A., and Poirier, M.C. Genotoxicity and
metabolism of the nucleoside reverse transcriptase inhibitor AZT. [Fifth
NIH Hispanic Scientist Day]{.underline}, NIH Bethesda, MD, 2004.

124\. Cooch, C. Vazquez, I.L. Poirier, M.C. and Olivero O.A. Zidovudine
(AZT)-phosphorylation and resistance is mediated by thymidine kinase 1
inhibition. [Fellows and Young Investigators Retreat]{.underline},
National Cancer Institute, Williamsburg, 2005.

125\. Sirajuddin, P, Castle, P. E.., Schiffman, M., Glass, A.G., Scott,
D.R., Rush, B.B., Olivero, O.A., Poirier, M.C. and Pratt, M.M. [Fellows
and Young Investigators Retreat]{.underline}, National Cancer Institute,
Williamsburg, 2005.

126\. Olivero, O.A., Vazquez, I.L., Cooch, C. Divi, R.L. and Poirier,
M.C. Nucleoside reverse transcriptase inhibitors alter the cell cycle
checkpoints of human cells in vitro. [American Association for Cancer
Research]{.underline}, Anaheim, CA, 2005.

127\. Olivero, O.A., Vazquez, I.L., Cooch, C. Divi, R.L., Weston, A. and
Poirier, M.C. Cyclin D- Rb pathway is altered during continuous exposure
of human cells to the antiretroviral drug Zidovudine (AZT). ). [9^th^
International Conference on Environmental Mutagens]{.underline}. San
Francisco, CA, 2005.

128\. Ming, J.M, Vazquez,I.L., Robinson, E.J., Poirier, M.C. and
Olivero, O.A.

> Long term effects of zidovudine in chronically exposed Molt-3 cells.
> [6^th^ NIH Hispanic Scientist Day]{.underline}, National Institutes of
> Health, Bethesda, MD. October 2005.

129. Torres, S.M., Cook, D.L. Jr., Walker, D.M., Olivero, O.A., Poirier,
     M.C., Walker, V.E. Analysis of Mutations in the p53 Tumor
     Suppressor Gene in CD-1 Mice Following Transplacental Exposure to
     AZT. National Conference Abstracts: [Society for Advancement of
     Chicanos and Native Americans in Science,]{.underline} October
     2005.

130\. Olivero, O.A, Ming, J.M, Vazquez,I.L., Robinson, E.J., Poirier,
M.C. Genotoxicity of the antiretroviral zidovudine in long term exposed
human lymphoblastoid cells *in vitro*. 45th

> [Annual meeting of the Society of Toxicology]{.underline}. San Diego,
> CA March, 2006.

131\. Torres, S.M., Cook, D.L., Walker, D.M., Olivero, O.A., Poirier,
M.C. and Walker, V.E.

> Refinement of PCR-based DGGE for analysis of mutations in the P53
> tumor suppressor gene following *in utero* exposures to NRTISs.
> [Annual meeting of the Society of Toxicology]{.underline}. San Diego,
> CA March, 2006.

132\. Olivero, O.A., Ming, J.M., Vazquez, I.L., Robinson, E. J. and
Poirier, M.C. The antiretroviral zidovudine alters the cell cycle and
induces metabolic resistance in human lymphoblastoid cells exposed
long-term *in vitro*. [Second Staff Scientists and Staff Clinicians
Annual Retreat, Gaithersburg, MD. March 2006]{.underline}.

 

133\. Pratt, M.M., Sirajuddin, P.P., Castle, P.E., Schiffman, M.,
Phillips, D.H., Senait A., Martin, F.L; Sram, R.J., Manchester, D.K.,
Olivero, O.A., and Poirier, M.C. Imaging and semiquantitation of
polycyclic aromatic hydrocarbon (PAH)-DNA adducts in human cervix,
vulva, placenta and prostate using Immunohistochemistry (IHC) and the
Automated Cellular Imaging System (ACIS). [American Association for
Cancer Research]{.underline} Washington, DC, April 2006.

134\. Olivero, O.A., Vazquez, I.L., Cooch, C. Ming, J., Weston, A. and
Poirier, M.C Human inter-individual variability in metabolic pathways
and genotoxic response to zidovudine. [American Association for Cancer
Research]{.underline}, Washington, DC, April 2006.

135\. Olivero, O.A.,Vazquez, I.L, Cooch, C, Ming, J.M., Weston, A., and
Poirier, M.C.

> Human inter-individual variability in metabolic pathways and genotoxic
> response to zidovudine. Genetic [Toxicology Association, Spring
> Meeting]{.underline}, Newark, DE, May 2006.

136\. Olivero, O.A., Ming, Jessica M., Ward Y., Semino-Mora, C.,
Robinson. E.J., Borojerdi, J.P., Cooch, C. Taylor, B.J. and Poirier,
M.C. The nucleoside analog Zidovudine induces centrosomal amplification
and abnormal chromosomal distribution in hamster and human cultured
cells. [50 years of 46 human chromosome research]{.underline}. Bethesda,
MD July 2006.

137\. Ming, J.M., Ward Y., Semino-Mora, C., Robinson.E. J., Taylor,
B.J., Poirier, M.C. and Olivero, O.A. The antiretroviral nucleoside
analog Zidovudine (AZT) induces centrosomal aberrations in cultured
human cells *in vitro*. Genetic and Environmentally Induced
Genotoxicity: Causes and Impact. [37^th^ Annual Meeting of the
Environmental Mutagen Society.]{.underline} Vancouver, British Columbia,
Canada, September 2006.

138\. Poirier MC, Shearer GM, Hardy AW, Olivero OA, Walker DM, Walker
VE. Antiretroviral activity of aminothiols, WR2721 and WR1065.
Retrovirology. 2006 Dec 21;3 Suppl 1:P78.

139\. Olivero OA, Borojerdi JP, Semino-Mora C, Ward Y, Poirier MC.
Genomic instability induced by AZT in cultured normal human mammary
epithelial cells (NHMECs) generates aneuploidy. Retrovirology. 2006 Dec
21;3 Suppl 1:P48.

140\. Olivero, O.A., Ming, J.M., Ward, Y., Semino-Mora, C., Robinson,
E.J.; Borojerdi, J.P., Cooch, C., Taylor, B.J., and Poirier, M.C. Cell
Cycle, Centrosomes and Cancer. Genotoxicity of the antiretroviral drug
AZT in hamster and human cells *in vitro*. International Course
Alexander Hollaender:"Genetic Toxicology: Nutritional and Environmental
Perspectives*.*

141\. Borojerdi, J.P., Ming, Jessica M., Ward Y., Semino-Mora, C.,
Robinson. E.J., Borojerdi, J.P., Cooch, C. Taylor, B.J. Poirier, M.C and
Olivero, O.A Genotoxicity of the Antiretroviral Drug AZT in Cultured
Cells. Annual Biomedical Research Conference for Minority Students.
November 8-11 2006. Anaheim CA.

.