Reaction SMILES: [F:1][C:2]([F:33])([F:32])[C:3]1[CH:4]=[C:5]([C@H:13]2[S:17][C:16](=[O:18])[N:15]([CH2:19][C:20]3[CH:25]=[C:24]([C:26]([F:29])([F:28])[F:27])[CH:23]=[CH:22][C:21]=3Br)[C@H:14]2[CH3:31])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.[O-]P([O-])([O-])=O.[K+].[K+].[K+].C([O:46][C:47]([C:49]1[CH:54]=[CH:53][C:52]([C:55]2[CH:60]=[CH:59][C:58]([O:61][CH3:62])=[C:57](B(O)O)[CH:56]=2)=[C:51]([CH3:66])[CH:50]=1)=[O:48])(C)(C)C>CN(C)C(=O)C.CCOC(C)=O.CCCCCC.CC(C1C=C(C(C)C)C(C2C=CC=C(P(C3CCCCC3)C3CCCCC3)C=2)=C(C(C)C)C=1)C.C1C=[C-]C(C2C(N)=CC=CC=2)=CC=1.Cl[Pd+]>[F:1][C:2]([F:33])([F:32])[C:3]1[CH:4]=[C:5]([C@H:13]2[S:17][C:16](=[O:18])[N:15]([CH2:19][C:20]3[CH:25]=[C:24]([C:26]([F:29])([F:28])[F:27])[CH:23]=[CH:22][C:21]=3[C:57]3[CH:56]=[C:55]([C:52]4[CH:53]=[CH:54][C:49]([C:47]([OH:48])=[O:46])=[CH:50][C:51]=4[CH3:66])[CH:60]=[CH:59][C:58]=3[O:61][CH3:62])[C@H:14]2[CH3:31])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1
Reactant: COc1ccc(-c2ccc(C(=O)OC(C)(C)C)cc2C)cc1B(O)O
Reactant: C[C@H]1[C@@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)SC(=O)N1Cc1cc(C(F)(F)F)ccc1Br
Agent: Cl[Pd+]
Agent: CC(C)c1cc(C(C)C)c(-c2cccc(P(C3CCCCC3)C3CCCCC3)c2)c(C(C)C)c1
Agent: Nc1ccccc1-c1[c-]cccc1
Solvent: CCOC(C)=O
Solvent: CC(=O)N(C)C
Solvent: CCCCCC
Product: COc1ccc(-c2ccc(C(=O)O)cc2C)cc1-c1ccc(C(F)(F)F)cc1CN1C(=O)S[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C
Temperature: 80 °C
Reaction time: 1 h

Procedure:
In a microwave vial was placed (4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-(2-bromo-5-(trifluoromethyl)benzyl)-4-methylthiazolidin-2-one (20 mg, 0.035 mmol) in N,N-Dimethylacetamide (0.5 ml). The mixture was degassed with N2, then chloro(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II) (2.78 mg, 3.53 μmol) was added, followed by potassium phosphate tribasic (0.035 ml, 0.071 mmol) and then (4′-(tert-butoxycarbonyl)-4-methoxy-2′-methyl-[1,1′-biphenyl]-3-yl)boronic acid (18.13 mg, 0.053 mmol) (synthesized according to the procedure reported in WO 2012/058187) under a N2 atmosphere. The resulting mixture was stirred at 80° C. for 1 hour. The reaction was diluted with 50% EtOAc in hexane, then was washed with satd. NH4Cl, then brine, and then the organic layer was dried over Na2SO4, filtered and concentrated. The residue was dissolved in 50% TFA in DCM and was stirred at r.t. for 45 min. The reagents were removed, the residue was dissolved in ACN:H2O (3:1) mixture, and was purified by a reverse phase purification system. 1H NMR (500 MHz, CDCl3, 1:1 mixture of atropisomers): δ 8.02 (d, J=12.5 Hz, 1H, contains protons of two atropisomers), 7.95 (d, J=8.5 Hz, 1H, contains protons of two atropisomers), 7.84 (d, J=10.5 Hz, 1H, contains protons of two atropisomers), 7.75 (s, 1H), 7.65 (m, 3H), 7.44 (m, 2H), 7.36 (d, J=7.5 Hz, 0.5H), 7.32 (d, J=7.5 Hz, 0.5H), 7.11 (d, J=3.5 Hz, 0.5H), 7.10 (d, J=3.5 Hz, 0.5H), 5.18 (d, J=15.5 Hz, 0.5H), 5.04 (d, J=15.5 Hz, 0.5H), 4.95 (d, J=7.0 Hz, 0.5H), 4.84 (d, J=7.5 Hz, 0.5H), 4.16 (d, J=15.5 Hz, 0.5H), 3.92 (d, 0.5H, one of the doublet peaks merged with a methoxy peak), 3.90 (s, 3H), 3.86 (s, 3H), 3.79 (m, 1H), 2.42 (s, 3H), 2.35 (s, 3H), 2.35 (s, 3H), 0.70 (d, J=6.5 Hz, 3H), 0.63 (d, J=6.5 Hz, 3H). MS ESI calc'd. for C35H26F9NO4 [M+H]+ 727.14. found 728.0. RTA (95% HS): 62 nM.