Reaction SMILES: [S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:11](=[O:142])[O:12][C:13]2[C:18]([CH:19]=1)=[CH:17][CH:16]=[C:15]([N:20]([CH2:24][C:25]1[N:26]=[N:27][N:28]([CH2:30][O:31][CH2:32][CH2:33][O:34][CH2:35][CH2:36][O:37][C:38]3[CH:39]=[C:40]([CH:63]=[C:64]([O:104][CH2:105][CH2:106][O:107][CH2:108][CH2:109][O:110][CH2:111][N:112]4[CH:116]=[C:115]([CH2:117][N:118]([C:122]5[CH:131]=[C:130]6[C:125]([CH:126]=[C:127]([C:133]7[S:134][C:135]8[CH:141]=[CH:140][CH:139]=[CH:138][C:136]=8[N:137]=7)[C:128](=[O:132])[O:129]6)=[CH:124][CH:123]=5)[CH:119]([CH3:121])[CH3:120])[N:114]=[N:113]4)[C:65]=3[O:66][CH2:67][CH2:68][O:69][CH2:70][CH2:71][O:72][CH2:73][N:74]3[CH:78]=[C:77]([CH2:79][N:80]([C:84]4[CH:93]=[C:92]5[C:87]([CH:88]=[C:89]([C:95]6[S:96][C:97]7[CH:103]=[CH:102][CH:101]=[CH:100][C:98]=7[N:99]=6)[C:90](=[O:94])[O:91]5)=[CH:86][CH:85]=4)[CH:81]([CH3:83])[CH3:82])[N:76]=[N:75]3)[C:41]([NH:43][CH2:44][C:45]3[CH:62]=[CH:61][C:48]([C:49]([O:51]CC4C=CC(OC)=CC=4)=[O:50])=[CH:47][CH:46]=3)=[O:42])[CH:29]=1)[CH:21]([CH3:23])[CH3:22])[CH:14]=2.FC(F)(F)C(O)=O.C(O)C>C(Cl)Cl>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:11](=[O:142])[O:12][C:13]2[C:18]([CH:19]=1)=[CH:17][CH:16]=[C:15]([N:20]([CH2:24][C:25]1[N:26]=[N:27][N:28]([CH2:30][O:31][CH2:32][CH2:33][O:34][CH2:35][CH2:36][O:37][C:38]3[CH:39]=[C:40]([CH:63]=[C:64]([O:104][CH2:105][CH2:106][O:107][CH2:108][CH2:109][O:110][CH2:111][N:112]4[CH:116]=[C:115]([CH2:117][N:118]([C:122]5[CH:131]=[C:130]6[C:125]([CH:126]=[C:127]([C:133]7[S:134][C:135]8[CH:141]=[CH:140][CH:139]=[CH:138][C:136]=8[N:137]=7)[C:128](=[O:132])[O:129]6)=[CH:124][CH:123]=5)[CH:119]([CH3:121])[CH3:120])[N:114]=[N:113]4)[C:65]=3[O:66][CH2:67][CH2:68][O:69][CH2:70][CH2:71][O:72][CH2:73][N:74]3[CH:78]=[C:77]([CH2:79][N:80]([C:84]4[CH:93]=[C:92]5[C:87]([CH:88]=[C:89]([C:95]6[S:96][C:97]7[CH:103]=[CH:102][CH:101]=[CH:100][C:98]=7[N:99]=6)[C:90](=[O:94])[O:91]5)=[CH:86][CH:85]=4)[CH:81]([CH3:83])[CH3:82])[N:76]=[N:75]3)[C:41]([NH:43][CH2:44][C:45]3[CH:46]=[CH:47][C:48]([C:49]([OH:51])=[O:50])=[CH:61][CH:62]=3)=[O:42])[CH:29]=1)[CH:21]([CH3:23])[CH3:22])[CH:14]=2
Reactant: COc1ccc(COC(=O)c2ccc(CNC(=O)c3cc(OCCOCCOCn4cc(CN(c5ccc6cc(-c7nc8ccccc8s7)c(=O)oc6c5)C(C)C)nn4)c(OCCOCCOCn4cc(CN(c5ccc6cc(-c7nc8ccccc8s7)c(=O)oc6c5)C(C)C)nn4)c(OCCOCCOCn4cc(CN(c5ccc6cc(-c7nc8ccccc8s7)c(=O)oc6c5)C(C)C)nn4)c3)cc2)cc1
Solvent: ClCCl
Solvent: O=C(O)C(F)(F)F
Solvent: CCO
Product: CC(C)N(Cc1cn(COCCOCCOc2cc(C(=O)NCc3ccc(C(=O)O)cc3)cc(OCCOCCOCn3cc(CN(c4ccc5cc(-c6nc7ccccc7s6)c(=O)oc5c4)C(C)C)nn3)c2OCCOCCOCn2cc(CN(c3ccc4cc(-c5nc6ccccc6s5)c(=O)oc4c3)C(C)C)nn2)nn1)c1ccc2cc(-c3nc4ccccc4s3)c(=O)oc2c1
Reaction time: 36 h
Yield: 94.9 %

Procedure:
To a solution in which the 4-methoxybenzyl 4-((3,4,5-tris(2-(2-((4-(((3-(benzo[d]thiazol-2-yl)-2-oxo-2H-chromen-7-yl)(isopropyl)amino)methyl)-1H-1,2,3-triazol-1-yl)methoxy)ethoxy) ethoxy)benzamido)methyl)benzoate (120 mg, 0.06 mmol) compound of Chemical Formula 16 was dissolved in methylene chloride (2 mL), trifluoroacetic acid (1 mL) was added at room temperature, and the mixture was stirred for 36 hours at the same temperature. Ethanol (10 mL) was added together when the post-reaction mixture was vacuum distilled to remove trifluoroacetic acid. This vacuum distillation was repeated 6 times to give 4-((3,4,5-tris(2-(2-((4-(((3-(benzo[d]thiazol-2-yl)-2-oxo-2H-chromen-7-yl)(isopropyl)amino)methyl)-1H-1,2,3-triazol-1-yl)methoxy)ethoxy) ethoxy)benzamido)methyl)benzoic acid (105.7 mg, 95%), and the product was immediately used for the next reaction without further purification.