Reaction SMILES: [BrH:1].Br.N(CC(C(N)CNC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1C=CC=CC=1)NC(=O)CNC(=O)[C@H](CCCCN)N(C(=O)CNC)C(=O)CCC(=O)NC1C=CC(C2C3NC(C(C4C=CC=CC=4)=C4N=C(C(C5C=CC=CC=5)=C5NC(=C(C6C=CC=CC=6)C6C=CC=2N=6)C=C5)C=C4)=CC=3)=CC=1)=O)C.C1(CO[C:116]([N:118]([CH2:120][C:121]([NH:123][CH2:124][CH2:125][NH:126][C:127](=[O:232])[CH2:128][NH:129][C:130](=[O:231])[C@H:131]([CH2:227][CH:228]([CH3:230])[CH3:229])[NH:132][C:133](=[O:226])[C@H:134]([CH2:219][C:220]2[CH:225]=[CH:224][CH:223]=[CH:222][CH:221]=2)[NH:135][C:136](=[O:218])[CH2:137][NH:138][C:139](=[O:217])[C@H:140]([CH2:212][CH2:213][CH2:214][CH2:215][NH2:216])[N:141]([C:197](=[O:211])[CH2:198][N:199](C(OCC2C=CC=CC=2)=O)[CH3:200])[C:142](=[O:196])[CH2:143][CH2:144][C:145](=[O:195])[NH:146][C:147]2[CH:152]=[CH:151][C:150]([C:153]3[C:154]4[NH:158][C:157]([C:159]([C:189]5[CH:194]=[CH:193][CH:192]=[CH:191][CH:190]=5)=[C:160]5[N:188]=[C:163]([C:164]([C:182]6[CH:187]=[CH:186][CH:185]=[CH:184][CH:183]=6)=[C:165]6[NH:181][C:168](=[C:169]([C:175]7[CH:180]=[CH:179][CH:178]=[CH:177][CH:176]=7)[C:170]7[CH:171]=[CH:172][C:173]=3[N:174]=7)[CH:167]=[CH:166]6)[CH:162]=[CH:161]5)=[CH:156][CH:155]=4)=[CH:149][CH:148]=2)=[O:122])C)=O)C=CC=CC=1.Br>C(O)(=O)C>[BrH:1].[BrH:1].[NH:118]([CH2:120][C:121]([NH:123][CH2:124][CH2:125][NH:126][C:127](=[O:232])[CH2:128][NH:129][C:130](=[O:231])[C@H:131]([CH2:227][CH:228]([CH3:229])[CH3:230])[NH:132][C:133](=[O:226])[C@H:134]([CH2:219][C:220]1[CH:225]=[CH:224][CH:223]=[CH:222][CH:221]=1)[NH:135][C:136](=[O:218])[CH2:137][NH:138][C:139](=[O:217])[C@H:140]([CH2:212][CH2:213][CH2:214][CH2:215][NH2:216])[N:141]([C:197](=[O:211])[CH2:198][NH:199][CH3:200])[C:142](=[O:196])[CH2:143][CH2:144][C:145](=[O:195])[NH:146][C:147]1[CH:148]=[CH:149][C:150]([C:153]2[C:154]3[NH:158][C:157]([C:159]([C:189]4[CH:194]=[CH:193][CH:192]=[CH:191][CH:190]=4)=[C:160]4[N:188]=[C:163]([C:164]([C:182]5[CH:183]=[CH:184][CH:185]=[CH:186][CH:187]=5)=[C:165]5[NH:181][C:168](=[C:169]([C:175]6[CH:176]=[CH:177][CH:178]=[CH:179][CH:180]=6)[C:170]6[CH:171]=[CH:172][C:173]=2[N:174]=6)[CH:167]=[CH:166]5)[CH:162]=[CH:161]4)=[CH:156][CH:155]=3)=[CH:151][CH:152]=1)=[O:122])[CH3:116]
Reactant: CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@H](CCCCN)N(C(=O)CCC(=O)Nc1ccc(-c2c3nc(c(-c4ccccc4)c4ccc([nH]4)c(-c4ccccc4)c4nc(c(-c5ccccc5)c5ccc2[nH]5)C=C4)C=C3)cc1)C(=O)CN(C)C(=O)OCc1ccccc1)C(=O)NCC(=O)NCCNC(=O)CN(C)C(=O)OCc1ccccc1
Agent: Br
Agent: CNCC(=O)C(N)CNC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@H](CCCCN)N(C(=O)CCC(=O)Nc1ccc(-c2c3nc(c(-c4ccccc4)c4ccc([nH]4)c(-c4ccccc4)c4nc(c(-c5ccccc5)c5ccc2[nH]5)C=C4)C=C3)cc1)C(=O)CNC
Solvent: CC(=O)O
Product: CNCC(=O)NCCNC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@H](CCCCN)N(C(=O)CCC(=O)Nc1ccc(-c2c3nc(c(-c4ccccc4)c4ccc([nH]4)c(-c4ccccc4)c4nc(c(-c5ccccc5)c5ccc2[nH]5)C=C4)C=C3)cc1)C(=O)CNC

Procedure:
N-(N-(N-(N-(N-Sarcosyl-N-(4-oxo-4-(4-(10,15,20-triphenyl-21H,23H-porphin-5-yl)phenylamino)butanoyl)lysyl)glycyl)phenylalanyl)leucyl)glycine N-(2-sarcosyl-aminoethyl)amide dihydrobromide. It is contemplated that N-(N-(N-(N-(N-(N-(Phenylmethoxycarbonyl)sarcosyl)-N-(4-oxo-4-(4-(10,15,20-triphenyl-21H,23H-porphin-5-yl)phenylamino)butanoyl)lysyl)glycyl)phenylalanyl)leucyl)glycine N-(2-(N-(phenylmethoxycarbonyl)sarcosylamino)ethyl)amide is stirred with 30% hydrogen bromide in acetic acid for 1 h. The solvent and excess reagent is evaporated under reduced pressure. Trituration of the residue with five portions of dry diethyl ether give N-(N-(N-(N-(N-sarcosyl-N-(4-oxo-4-(4-(10,15,20-triphenyl-21H,23H-porphin-5-yl)-phenylamino)butanoyl)lysyl)glycyl)phenylalanyl)leucyl)glycine N-(2-sarcosylamino-ethyl)amide dihydrobromide.