Reaction SMILES: [CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([Bi]([C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=2)C2C=CC(OC)=CC=2)=[CH:5][CH:4]=1.C(OO)(=O)C.[CH2:31]([CH:33]1[CH:59]=[C:58]([CH3:60])[CH2:57][CH:56]([CH3:61])[CH2:55][CH:54]([O:62][CH3:63])[CH:53]2[O:64][C:49]([OH:68])([CH:50]([CH3:67])[CH2:51][CH:52]2[O:65][CH3:66])[C:48](=[O:69])[C:47](=[O:70])[N:46]2[CH:41]([CH2:42][CH2:43][CH2:44][CH2:45]2)[C:40](=[O:71])[O:39][CH:38]([C:72]([CH3:82])=[CH:73][CH:74]2[CH2:79][CH2:78][CH:77]([OH:80])[CH:76]([OH:81])[CH2:75]2)[CH:37]([CH3:83])[CH:36]([OH:84])[CH2:35][C:34]1=[O:85])[CH3:32].C1COCC1>C(Cl)Cl.C([O-])(=O)C.[Cu+2].C([O-])(=O)C>[CH2:31]([CH:33]1[CH:59]=[C:58]([CH3:60])[CH2:57][CH:56]([CH3:61])[CH2:55][CH:54]([O:62][CH3:63])[CH:53]2[O:64][C:49]([OH:68])([CH:50]([CH3:67])[CH2:51][CH:52]2[O:65][CH3:66])[C:48](=[O:69])[C:47](=[O:70])[N:46]2[CH:41]([CH2:42][CH2:43][CH2:44][CH2:45]2)[C:40](=[O:71])[O:39][CH:38]([C:72]([CH3:82])=[CH:73][CH:74]2[CH2:79][CH2:78][CH:77]([O:80][C:18]3[CH:19]=[CH:20][C:21]([O:24][CH3:25])=[CH:22][CH:23]=3)[CH:76]([OH:81])[CH2:75]2)[CH:37]([CH3:83])[CH:36]([OH:84])[CH2:35][C:34]1=[O:85])[CH3:32].[CH2:31]([CH:33]1[CH:59]=[C:58]([CH3:60])[CH2:57][CH:56]([CH3:61])[CH2:55][CH:54]([O:62][CH3:63])[CH:53]2[O:64][C:49]([OH:68])([CH:50]([CH3:67])[CH2:51][CH:52]2[O:65][CH3:66])[C:48](=[O:69])[C:47](=[O:70])[N:46]2[CH:41]([CH2:42][CH2:43][CH2:44][CH2:45]2)[C:40](=[O:71])[O:39][CH:38]([C:72]([CH3:82])=[CH:73][CH:74]2[CH2:79][CH2:78][CH:77]([OH:80])[CH:76]([O:81][C:6]3[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=3)[CH2:75]2)[CH:37]([CH3:83])[CH:36]([OH:84])[CH2:35][C:34]1=[O:85])[CH3:32]
Reactant: COc1ccc([Bi](c2ccc(OC)cc2)c2ccc(OC)cc2)cc1
Reactant: CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(O)C(O)C3)C(C)C(O)CC1=O)C(C)CC2OC
Agent: [Cu+2]
Agent: CC(=O)OO
Agent: CC(=O)[O-]
Solvent: ClCCl
Solvent: C1CCOC1
Product: CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(O)C(Oc4ccc(OC)cc4)C3)C(C)C(O)CC1=O)C(C)CC2OC
Product: CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(Oc4ccc(OC)cc4)C(O)C3)C(C)C(O)CC1=O)C(C)CC2OC
Reaction time: 168 h

Procedure:
To a stirred solution of tri(4-methoxyphenyl)bismuthine (136 mg., 0.257 mmol., 2 eq.) in methylene chloride (4 mL.) was added peracetic acid (0.054 mL., 0.257 mmol., 2 eq., 32% solution in dilute acetic acid). To this stirred solution was added 17-ethyl-1,14-dihydroxy-12-[2'-(3",4"-dihydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9 ]octacos-18-ene-2,3,10,16-tetraone (100 mg., 0.126 mmol., 1 eq.), THF (0.5 mL.), and copper (II) acetate (7 mg., 0.038 mmol., 0.3 eq.). The mixture was allowed to stir for 7 days. The reaction was quenched with saturated aqueous NaCl plus 2 drops 2N HCl and extracted 4× with methylene chloride. The organic extracts were combined, dried over anhydrous Na2SO4, filtered, and concentrated in vacuo. The products were separated by preparative TLC on silica gel (2:1 hexanes/acetone). Each compound was repurified 2× by preparative TLC on silica gel (3:1 hexanes/acetone then 3.5% MeOH/CH2Cl2) affording 23.4 mg of 17-ethyl-1,14-dihydroxy-12-[2'-(4"-(4'"-methoxyphenyloxy)-3"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9 ]octacos-18-ene-2,3,10,16-tetraone and 28.4 mg of 17-ethyl-1,14-dihydroxy-12-[2'-(3"-(4'"-methoxyphenyloxy)-4"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9 ]octacos-18-ene-2,3,10,16-tetraone. (1H NMR and mass spectral analysis were consistent with the desired structures).