Reaction SMILES: Br[C:2]1[CH:7]=[CH:6][C:5]([C:8](=[C:16]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)[C:9]2[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=2)=[CH:4][C:3]=1[F:23].[C:24]([O:28][C:29](=[O:32])[CH:30]=[CH2:31])([CH3:27])([CH3:26])[CH3:25].CC1C=CC=CC=1P(C1C=CC=CC=1C)C1C=CC=CC=1C>C([O-])(=O)C.[Pd+2].C([O-])(=O)C.Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.CN(C=O)C.C(N(CC)CC)C.CC#N>[C:16]1(=[C:8]([C:9]2[CH:10]=[CH:11][C:12]([OH:15])=[CH:13][CH:14]=2)[C:5]2[CH:6]=[CH:7][C:2](/[CH:31]=[CH:30]/[C:29]([O:28][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:32])=[C:3]([F:23])[CH:4]=2)[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1
Reactant: Oc1ccc(C(=C2CCCCCC2)c2ccc(Br)c(F)c2)cc1
Reactant: C=CC(=O)OC(C)(C)C
Agent: Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1
Agent: [Pd+2]
Agent: CC(=O)[O-]
Solvent: CN(C)C=O
Solvent: CCN(CC)CC
Solvent: CC#N
Product: CC(C)(C)OC(=O)/C=C/c1ccc(C(=C2CCCCCC2)c2ccc(O)cc2)cc1F
Temperature: 75 °C

Procedure:
To a round-bottomed flask were added 4-[(4-bromo-3-fluorophenyl)(cycloheptylidene)methyl]phenol (187) (0.21 g, 0.56 mmoL), tert-butylacrylate (0.25 mL, 0.22 g, 1.7 mmoL), palladium(II) acetate (0.023 g, 0.10 mmoL), triethylamine (0.22 mL, 0.16 g, 1.6 mmoL), P(o-tolyl)3 (0.071 g, 0.23 mmol) and anhydrous CH3CN (10 mL). The stirred reaction mixture was heated at 75° C. under a nitrogen atmosphere for 15 h. The oil bath was removed and the reaction mixture was allowed to cool at RT. Thin layer chromatography (hexanes:EtOAc (9:1)) indicated that only starting material was present. The reaction mixture was concentrated in vacuo to give an orange oil. To the oil were added tert-butylacrylate (0.82 mL, 0.72 g, 5.6 mmoL), triethylamine (0.40 mL, 0.29 g, 2.87 mmoL), dichlorobis(triphenylphosphine)palladium(II) (0.091 g, 0.13 mmoL), and anhydrous DMF (5 mL). The stirred reaction mixture was heated overnight at 110° C. under a nitrogen atmosphere. The oil bath was removed and the dark brown reaction mixture was allowed to cool at RT. The reaction mixture was partitioned between EtOAc and H2O. The layers were separated and the organic phase was dried over MgSO4, filtered, and the filtrate was concentrated in vacuo to give the crude acrylate ester. The acrylate ester intermediate was partially purified by flash chromatography on silica gel with a hexanes:EtOAc gradient (100:0 to 50:50) to give 0.1719 of impure 1,1-dimethylethyl (2E)-3-{4-[cycloheptylidene(4-hydroxyphenyl)methyl]-2-fluorophenyl}-2-propenoate. To a stirred solution of the impure tert-butylacrylate ester (0.17 g) in CH2Cl2 (4 mL) was added trifluoroacetic acid (2 mL) at RT. The reaction mixture was stirred at RT under a nitrogen atmosphere for 2.75 h. The reaction mixture was concentrated in vacuo to give the crude acrylic acid. The crude product was purified by reverse phase preparative HPLC using a C-18 column and a CH3CN:H2O gradient (75:25 to 100:0) with 0.05% TFA as a modifier to give 0.080 g (39% over two steps) of compound 188 as a pale yellow solid. 1H NMR (400 MHz, DMSO-d6): δ 1.50 (m, 8H), 2.21 (m, 4H), 6.51 (d, J=16.1 Hz, 1H), 6.67 (d, J=8.4 Hz, 2H), 6.92 (d, J=8.2 Hz, 2H), 6.97 (m, 2H), 7.58 (d, J=16.1 Hz, 1H), 7.72 (t, J=8.2 Hz, 1H), 9.32 (s, 1H), 12.50 (br s, 1H). HRMS (ESI) Calcd for C23H22O3F: 365.1553 (M−H)−. Found: 365.1570.