Reaction SMILES: CN(C)C(=O)C[CH2:5][N:6]([CH3:35])[C:7]1[CH:12]=[CH:11][C:10]([NH:13]/[C:14](/[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[C:15]2\[C:16](=[O:28])[NH:17][C:18]3[C:23]\2=[CH:22][CH:21]=[C:20]([C:24]([O:26][CH3:27])=[O:25])[N:19]=3)=[CH:9][CH:8]=1.O=S1(=O)CCN(C[C:46]([N:48]([C:50]2C=CC(N/C(/C3C=CC=CC=3)=C3\C(=O)NC4C\3=CC=C(C(OC)=O)N=4)=C[CH:51]=2)[CH3:49])=[O:47])CC1.CN(C)CC(N(C1C=CC(N/C(/C2C=CC=CC=2)=C2\C(=O)NC3C\2=CC=C(C(OC)=O)N=3)=CC=1)C)=O.CN(CCN1CCN(C)CC1)C1C=CC(N/C(/C2C=CC=CC=2)=C2\C(=O)NC3C\2=CC=C(C(OC)=O)N=3)=CC=1.C(N(C)C(=O)CN(C)C1C=CC(N/C(/C2C=CC=CC=2)=C2\C(=O)NC3C=C(C(OC)=O)N=CC\2=3)=CC=1)C.CN(C)C(=O)CCN(C)C1C=CC(N/C(/C2C=CC=CC=2)=C2\C(=O)NC3C=C(C(OC)=O)N=CC\2=3)=CC=1.O=S1(=O)CCN(CC(N(C2C=CC(N/C(/C3C=CC=CC=3)=C3\C(=O)NC4C=C(C(OC)=O)N=CC\3=4)=CC=2)C)=O)CC1.CN(C)CC(N(C1C=CC(N/C(/C2C=CC=CC=2)=C2\C(=O)NC3C=C(C(OC)=O)N=CC\2=3)=CC=1)C)=O.CN(CCN1CCN(C)CC1)C1C=CC(N/C(/C2C=CC=CC=2)=C2\C(=O)NC3C=C(C(OC)=O)N=CC\2=3)=CC=1.C(N(C)C(=O)CN(C)C1C=CC(N/C(/C2C=CC=CC=2)=C2\C(=O)NC3C\2=NC=C(C(OC)=O)C=3)=CC=1)C.CN(C)C(=O)CCN(C)C1C=CC(N/C(/C2C=CC=CC=2)=C2\C(=O)NC3C\2=NC=C(C(OC)=O)C=3)=CC=1.O=S1(=O)CCN(CC(N(C2C=CC(N/C(/C3C=CC=CC=3)=C3\C(=O)NC4C\3=NC=C(C(OC)=O)C=4)=CC=2)C)=O)CC1.CN(C)CC(N(C1C=CC(N/C(/C2C=CC=CC=2)=C2\C(=O)NC3C\2=NC=C(C(OC)=O)C=3)=CC=1)C)=O.CN(CCN1CCN(C)CC1)C1C=CC(N/C(/C2C=CC=CC=2)=C2\C(=O)NC3C\2=NC=C(C(OC)=O)C=3)=CC=1>>[CH2:50]([N:48]([CH3:49])[C:46](=[O:47])[CH2:5][N:6]([CH3:35])[C:7]1[CH:12]=[CH:11][C:10]([NH:13]/[C:14](/[C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)=[C:15]2\[C:16](=[O:28])[NH:17][C:18]3[C:23]\2=[CH:22][CH:21]=[C:20]([C:24]([O:26][CH3:27])=[O:25])[N:19]=3)=[CH:9][CH:8]=1)[CH3:51]
Reactant: COC(=O)c1ccc2c(n1)NC(=O)/C2=C(\Nc1ccc(N(C)CCC(=O)N(C)C)cc1)c1ccccc1
Reactant: COC(=O)c1ccc2c(n1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCS(=O)(=O)CC2)cc1)c1ccccc1
Agent: CCN(C)C(=O)CN(C)c1ccc(N/C(=C2\C(=O)Nc3cc(C(=O)OC)cnc32)c2ccccc2)cc1
Agent: CCN(C)C(=O)CN(C)c1ccc(N/C(=C2\C(=O)Nc3cc(C(=O)OC)ncc32)c2ccccc2)cc1
Agent: COC(=O)c1cc2c(cn1)/C(=C(/Nc1ccc(N(C)C(=O)CN(C)C)cc1)c1ccccc1)C(=O)N2
Product: CCN(C)C(=O)CN(C)c1ccc(N/C(=C2\C(=O)Nc3nc(C(=O)OC)ccc32)c2ccccc2)cc1

Procedure:
(Z)-methyl 3-(((4-((3-(dimethylamino)-3-oxopropyl)(methyl)amino)phenyl)amino)(phenyl)methylene)-2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-6-carboxylate; (Z)-methyl 3-(((4-(2-(1,1-dioxidothiomorpholino)-N-methylacetamido)phenyl)amino)(phenyl)methylene)-2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-6-carboxylate; (Z)-methyl 3-(((4-(2-(dimethylamino)-N-methylacetamido)phenyl)amino)(phenyl)methylene)-2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-6-carboxylate; (Z)-methyl 3-(((4-(methyl(2-(4-methylpiperazin-1-yl)ethyl)amino)phenyl)amino)(phenyl)methylene)-2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-6-carboxylate; (Z)-methyl 3-(((4-((2-(ethyl(methyl)amino)-2-oxoethyl)(methyl)amino)phenyl)amino)(phenyl)methylene)-2-oxo-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine-6-carboxylate; (Z)-methyl 3-(((4-((3-(dimethylamino)-3-oxopropyl)(methyl)amino)phenyl)amino)(phenyl)methylene)-2-oxo-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine-6-carboxylate; (Z)-methyl 3-(((4-(2-(1,1-dioxidothiomorpholino)-N-methylacetamido)phenyl)amino)(phenyl)methylene)-2-oxo-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine-6-carboxylate; (Z)-methyl 3-(((4-(2-(dimethylamino)-N-methylacetamido)phenyl)amino)(phenyl)methylene)-2-oxo-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine-6-carboxylate; (Z)-methyl 3-(((4-(methyl(2-(4-methylpiperazin-1-yl)ethyl)amino)phenyl)amino)(phenyl)methylene)-2-oxo-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine-6-carboxylate; (Z)-methyl 3-(((4-((2-(ethyl(methyl)amino)-2-oxoethyl)(methyl)amino)phenyl)amino)(phenyl)methylene)-2-oxo-2,3-dihydro-1H-pyrrolo[3,2-b]pyridine-6-carboxylate; (Z)-methyl 3-(((4-((3-(dimethylamino)-3-oxopropyl)(methyl)amino)phenyl)amino)(phenyl)methylene)-2-oxo-2,3-dihydro-1H-pyrrolo[3,2-b]pyridine-6-carboxylate; (Z)-methyl 3-(((4-(2-(1,1-dioxidothiomorpholino)-N-methylacetamido)phenyl)amino)(phenyl)methylene)-2-oxo-2,3-dihydro-1H-pyrrolo[3,2-b]pyridine-6-carboxylate; (Z)-methyl 3-(((4-(2-(dimethylamino)-N-methylacetamido)phenyl)amino)(phenyl)methylene)-2-oxo-2,3-dihydro-1H-pyrrolo[3,2-b]pyridine-6-carboxylate; and (Z)-methyl 3-(((4-(methyl(2-(4-methylpiperazin-1-yl)ethyl)amino)phenyl)amino)(phenyl)methylene)-2-oxo-2,3-dihydro-1H-pyrrolo[3,2-b]pyridine-6-carboxylate.