Azzindani/Open_Reaction_Data huggingface dataset:
Reaction SMILES: [CH3:1][C:2]1[CH2:7][CH2:6][CH2:5][C:4]([CH3:9])([CH3:8])[C:3]=1/[CH:10]=[CH:11]/[C:12](/[CH3:22])=[CH:13]/[CH:14]=[CH:15]/[C:16](/[CH3:21])=[CH:17]/[C:18]([OH:20])=O.C(Cl)(=O)C(Cl)=O.[Cl-].[NH2:30][C:31]1[CH:36]=[CH:35][C:34]([OH:37])=[CH:33][CH:32]=1.C(N(CC)CC)C>CN(C=O)C.C(Cl)Cl>[CH3:1][C:2]1[CH2:7][CH2:6][CH2:5][C:4]([CH3:8])([CH3:9])[C:3]=1/[CH:10]=[CH:11]/[C:12](/[CH3:22])=[CH:13]/[CH:14]=[CH:15]/[C:16](/[CH3:21])=[CH:17]/[C:18]([NH:30][C:31]1[CH:32]=[CH:33][C:34]([OH:37])=[CH:35][CH:36]=1)=[O:20]
Reactant: CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1
Reactant: Nc1ccc(O)cc1
Agent: O=C(Cl)C(=O)Cl
Agent: [Cl-]
Solvent: CN(C)C=O
Solvent: ClCCl
Solvent: CCN(CC)CC
Product: CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)Nc2ccc(O)cc2)C(C)(C)CCC1
Reaction time: 1 h

Procedure:
A mixture of all-trans retinoic acid (ATRA) (200 mg, 0.66 mmol) in dry DMF (2 mL) and dry CH2Cl2 (2 mL) was stirred under nitrogen atmosphere for 1 h. Oxalyl chloride (2.5 mmol, 215 μL) was added drop by drop at 0° C. The deep red reaction mixture was stirred for another 1.5 h at room temperature under nitrogen atmosphere. Very carefully removed the solvent, then added dry DMF (2 mL) for immediate use. At 0° C. under nitrogen atmosphere, Retinoyl chloride solution was added dropwise to a solution of 4-aminophenol (1.331 mmol, 145.3 mg) and triethylamine (1.997 mmol, 280 μL) in dry DMF (2 mL). The dark-colored reaction mixture was stirred at room temperature until TLC analysis indicated none remaining (about 2˜3 h). The reaction was quenched with saturated NH4Cl and extracted with ethyl acetate. The extracts were washed with H2O and brine, then dried overage Na2SO4, and evaporated. The residue was purified by flash column chromatography using hexane/ethyl acetate (3/1) as the eluent to give 4-HPR as a yellow solid. 1H-NMR(300 MHz, CDCl3): δ7.42 (d, 2H), 7.11 (s, 1H), 6.99 (dd, 1H), 6.83 (d, 2H), 6.33˜6.18 (m, 4H), 5.80 (s, 1H), 2.44 (s, 3H), 2.04 (br s, 5H), 1.74 (s, 3H), 1.64˜1.62 (m, 2H), 1.33 (m, 2H), 1.05 (s, 6H).
Reaction SMILES: [Cl:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH3:9])=[CH:4][N:3]=1.Br[C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([CH3:17])[C:12]=1[CH3:18].CC1(C)C2C(=C(P(C3C=CC=CC=3)C3C=CC=CC=3)C=CC=2)OC2C(P(C3C=CC=CC=3)C3C=CC=CC=3)=CC=CC1=2.C(=O)([O-])[O-].[Cs+].[Cs+]>O1CCOCC1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>[Cl:1][C:2]1[N:7]=[C:6]([NH:8][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([CH3:17])[C:12]=2[CH3:18])[C:5]([CH3:9])=[CH:4][N:3]=1
Reactant: Cc1cccc(Br)c1C
Reactant: Cc1cnc(Cl)nc1N
Agent: [Pd]
Agent: CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21
Agent: O=C(/C=C/c1ccccc1)/C=C/c1ccccc1
Solvent: C1COCCO1
Product: Cc1cnc(Cl)nc1Nc1cccc(C)c1C

Procedure:
A mixture of 2-chloro-5-methylpyrimidin-4-amine (143.6 mg, 1 mmol), 1-bromo-2,3-dimethylbenzene (222 mg, 1.2 mmol), Pd2(dba)3 (92 mg, 0.1 mmol), Xantphos (174 mg, 0.3 mmol) and cesium carbonate (1.3 g, 4 mmol) were suspended in dioxane (150 mL) and heated at reflux under the argon atmosphere for 20 h. The mixture was filtered and the filtrate concentrated in vacuo. The residue was dissolved in EtOAc (10 mL) and added hexanes (100 mL). The solid was collected by filtration and washed with hexanes to afford the crude title compound as a yellow solid.
Reaction SMILES: [CH3:1][N:2]([CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6])[NH2:3].[CH2:10]([N:17]=[C:18]=[O:19])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[CH3:1][N:2]([CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6])[NH:3][C:18](=[O:19])[NH:17][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1
Reactant: O=C=NCc1ccccc1
Reactant: CCOC(=O)CN(C)N
Product: CCOC(=O)CN(C)NC(=O)NCc1ccccc1
Reaction time: 8 h
Yield: 75.4 %

Procedure:
According to the procedure described in the synthesis method of Compound V-1 with the modification that the reaction was carried out overnight, ethyl 2-(1-methylhydrazinyl)acetate (Compound XV-2) 10 ml (76 mmol) was reacted with benzyl isocyanate 11.1 g (83.3 mmol) to obtain the title compound 15.2 g (76%).
Reaction SMILES: [OH:1][N:2]=[C:3]([C:5]1[C:9]([NH:10][CH2:11][CH2:12][CH2:13][NH:14][S:15]([CH3:18])(=[O:17])=[O:16])=[N:8][O:7][N:6]=1)[NH2:4].[Br:19][C:20]1[CH:21]=[C:22]([CH:24]=[CH:25][C:26]=1[F:27])N>>[Br:19][C:20]1[CH:21]=[C:22]([NH:4][C:3]([C:5]2[C:9]([NH:10][CH2:11][CH2:12][CH2:13][NH:14][S:15]([CH3:18])(=[O:17])=[O:16])=[N:8][O:7][N:6]=2)=[N:2][OH:1])[CH:24]=[CH:25][C:26]=1[F:27]
Reactant: CS(=O)(=O)NCCCNc1nonc1C(N)=NO
Reactant: Nc1ccc(F)c(Br)c1
Product: CS(=O)(=O)NCCCNc1nonc1C(=NO)Nc1ccc(F)c(Br)c1
Yield: 12 %

Procedure:
The title compound was prepared according to the procedure of Example 17, step E, using N′-hydroxy-4-({3-[(methylsulfonyl)amino]propyl}amino)-1,2,5-oxadiazole-3-carboximidamide and 3-bromo-4-fluoroaniline [Oakwood Products, Inc., product #013091] as the starting materials in 12% yield. LCMS for C13H17BrFN6O4S (M+H)+: m/z=451.0, 453.0. 1H NMR (400 MHz, CD3OD): δ 7.12 (dd, J=5.9, 2.4 Hz, 1H), 7.05 (t, J=8.7 Hz, 1H), 6.83 (m, 1H), 3.39 (t, J=6.8 Hz, 2H), 3.14 (t, J=6.6 Hz, 2H), 2.94 (s, 3H), 1.87 (m, 2H).
Reaction SMILES: Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12](=[O:14])[CH3:13])=[C:5]2[NH:15][C@H:16]1[CH2:21][CH2:20][C@H:19]([CH2:22][N:23]2[CH2:27][CH2:26][CH2:25][CH2:24]2)[CH2:18][CH2:17]1.[Cl:28][C:29]1[CH:34]=[C:33](B2OC(C)(C)C(C)(C)O2)[CH:32]=[C:31]([Cl:44])[C:30]=1[OH:45].Cl>ClCCl.CO>[ClH:28].[Cl:44][C:31]1[CH:32]=[C:33]([C:2]2[CH:3]=[C:4]3[C:9](=[CH:10][CH:11]=2)[N:8]=[CH:7][C:6]([C:12](=[O:14])[CH3:13])=[C:5]3[NH:15][C@H:16]2[CH2:17][CH2:18][C@H:19]([CH2:22][N:23]3[CH2:27][CH2:26][CH2:25][CH2:24]3)[CH2:20][CH2:21]2)[CH:34]=[C:29]([Cl:28])[C:30]=1[OH:45]
Reactant: CC(=O)c1cnc2ccc(Br)cc2c1N[C@H]1CC[C@H](CN2CCCC2)CC1
Reactant: CC1(C)OB(c2cc(Cl)c(O)c(Cl)c2)OC1(C)C
Agent: Cl
Solvent: ClCCl
Solvent: CO
Product: CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)cc2c1N[C@H]1CC[C@H](CN2CCCC2)CC1

Procedure:
Following general procedure F, 1-(6-bromo-4-(trans-4-(pyrrolidin-1-ylmethyl)cyclohexylamino)quinolin-3-yl)ethanone (6.0 g, 14.0 mmol) was reacted with 2,6-dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (4.4 g, 15.0 mmol) to obtain the free base. The purified product was suspended in dichloromethane/methanol (1:1, 200 mL) after which HCl (35 mL, 1.25 M in methanol) was added to form a solution. The solution was concentrated to dryness and the resultant solid was triturated with dichloromethane. The mixture was filtered, washed with dichloromethane, and dried to obtain desired product (4.9 g, 60% over two steps) as a yellow solid: 1H NMR (300 MHz, CD3OD) δ 9.10 (s, 1H), 8.47 (d, J=2.1 Hz, 1H), 8.26 (dd, J=8.8, 1.8 Hz, 1H), 7.98 (d, J=8.8 Hz, 1H), 7.73 (s, 2H), 4.55-4.45 (m, 1H), 3.70 (br s, 2H), 3.20-3.04 (m, 4H), 2.74 (s, 3H), 2.45 (d, J=12.6 Hz, 2H), 2.17-1.94 (m, 7H), 1.89-1.70 (m, 2H), 1.46-1.27 (m, 2H); APCI MS m/z 512 [C28H31Cl2N3O2+H]+; HPLC>99% (AUC), tR=8.69 min.
Reaction SMILES: [CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[CH:5][CH:4]=1.[C:10]1(=O)[CH2:14][CH2:13][CH2:12][CH2:11]1.C(O)(=O)C.C([BH3-])#N.[Na+]>CO.C1COCC1>[CH:10]1([NH:9][C:6]2[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[CH2:14][CH2:13][CH2:12][CH2:11]1
Reactant: COc1ccc(N)cc1
Reactant: O=C1CCCC1
Agent: [BH3-]C#N
Agent: [Na+]
Solvent: CC(=O)O
Solvent: C1CCOC1
Solvent: CO
Product: COc1ccc(NC2CCCC2)cc1
Temperature: 25 °C
Reaction time: 18 h

Procedure:
To a stirred solution of 7.00 g (56.8 mmol) p-Anisidine, 9.56 g (114 mmol, 2.0 equiv) Cyclopentanone, and 4.10 g (68.2 mmol, 1.2 equiv) Acetic acid in 145 mL Methanol is added 125 mL (125 mmol, 2.2 equiv) 1N Sodium cyanoborohydride in THF and stirred 18 h at ambient temperature. The reaction mixture is concentrated in vacuo and the residue taken into 200 mL EtOAc, washed with H2O (150 mL), dried (MgSO4), filtered and concentrated in vacuo to give crude Cyclopentyl-(4-methoxy-phenyl)-amine as a brown oil. To a stirred solution of this material and 6.03 g (58.6 mmol, 1.05 equiv) Et3N in 70 mL DCM is added 11.47 g (56.8 mmol, 1 equiv) Bromoacetyl bromide in 50 mL DCM dropwise over 30 minutes at 0° C. The reaction mixture is stirred 1 h at 0° C. followed by warming to ambient temperature and stirring 18 h. The reaction mixture is washed with 1N HCl (3×50 mL), dried (MgSO4), filtered through a pad of 100 g silica gel eluted with EtOAc/Hexanes (3:17, 1.5 L), and concentrated in vacuo to give 10.22 g (32.7 mmol) of 2-Bromo-N-cyclopentyl-N-(4-methoxy-phenyl)-acetamide as an orange oil: 1H NMR (CDCl3, 300 MHz) δ7.09 (d, 2H, J=9.0), 6.90 (d, 2H, J=9.0), 4.84 (m,1H), 3.83 (s, 3H), 3.54 (s, 2H), 1.87 (m, 2H), 1.49 (m, 4H), 1.25 (m, 2H); TLC Rf =0.65 (EtOAc/Hexanes, 3:17).
Reaction SMILES: [CH3:1][O:2][CH2:3][CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][CH:9]([C:12]([O:14]CC)=[O:13])[CH2:8][CH2:7]1.O1CCCC1.O.O.[OH-].[Li+]>C(OC(=O)C)C>[CH3:1][O:2][CH2:3][CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][CH:9]([C:12]([OH:14])=[O:13])[CH2:8][CH2:7]1
Reactant: CCOC(=O)C1CCN(CCCOC)CC1
Agent: [Li+]
Agent: [OH-]
Solvent: CCOC(C)=O
Solvent: O
Solvent: C1CCOC1
Product: COCCCN1CCC(C(=O)O)CC1
Temperature: 25 °C
Reaction time: 16 h
Yield: 100 %

Procedure:
To a stirred mixture of ethyl 1-(3-methoxy propyl)piperidin-4-carboxylate (33.0 grams, 144.1 mmol, obtained in the above step), tetrahydrofuran (200 mL) and water (200 mL) was added lithium hydroxide monohydrate (6.1 grams, 144.1 mmol). The reaction mixture was stirred at room temperature for 16 hours before being diluted with ethylacetate. The two layers were separated and the aqueous layer was acidified to pH: 3-4 with concentrated hydrochloric acid and the volatiles were removed under reduced pressure to obtain 1-(3-methoxy propyl)piperidin-4-carboxylic acid (35.0 grams).
Reaction SMILES: [O:1]1[CH:5]=[CH:4][C:3]([C:6]2[N:11]=[C:10]([C:12]3[N:16]4[CH:17]=[CH:18][C:19]([C:21]([CH3:31])([O:23][Si](CC)(CC)CC)[CH3:22])=[N:20][C:15]4=[N:14][CH:13]=3)[CH:9]=[CH:8][N:7]=2)=[CH:2]1>CCO.Cl>[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[N:11]=[C:10]([C:12]3[N:16]4[CH:17]=[CH:18][C:19]([C:21]([OH:23])([CH3:22])[CH3:31])=[N:20][C:15]4=[N:14][CH:13]=3)[CH:9]=[CH:8][N:7]=2)=[CH:2]1
Reactant: CC[Si](CC)(CC)OC(C)(C)c1ccn2c(-c3ccnc(-c4ccoc4)n3)cnc2n1
Agent: Cl
Solvent: CCO
Product: CC(C)(O)c1ccn2c(-c3ccnc(-c4ccoc4)n3)cnc2n1
Temperature: 25 °C
Reaction time: 12 h
Yield: 42.4 %

Procedure:
3-[2-(Furan-3-yl)pyrimidin-4-yl]-7-(1-methyl-1-triethylsilanyloxyethyl)imidazo[1,2-α]pyrimidine (203 mg, 0.47 mmol) in EtOH (10 ml) was treated with conc. HCl (15 drops) and the resulting solution was stirred at room temperature for 12 h during which time a precipitate formed. The solid was filtered off and was then partitioned between CH2Cl2 (20 ml) and NaHCO3 solution (20 ml). The organic layer was separated and the aqueous extracted with CH2Cl2 (3×20 ml). The combined organic extracts were dried (MgSO4) and concentrated under reduced pressure to afford 2-[3-(2-(furan-3-yl)pyrimidin-4-yl)imidazo[1,2-α]pyrimidin-7-yl]propan-2-ol (64 mg, 42%): 1H NMR (400 MHz, d6-DMSO) δ 10.29 (1H, d, J 7.3), 8.81 (1H, s), 8.77 (1H, d, J 5.4), 8.68 (1H, s), 7.89 (1H, d, J 5.4), 7.87 (1H, s), 7.74 (1H, d, J 7.3), 7.20 (1H, s), 5.61 (1H, s), 1.54 (6H, s); m/z (ES+) 322 (M+H+).
Reaction SMILES: [Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]3[CH2:13][N:14]([C:17](=[O:19])[CH3:18])[CH2:15][CH2:16][C:11]=3[N:10]([CH2:20][CH:21]([OH:36])[CH2:22][N:23]3[CH2:28][CH2:27][N:26]([C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=4[CH3:35])[CH2:25][CH2:24]3)[N:9]=2)=[CH:4][CH:3]=1.[H-].[Na+].CI.CO.[CH2:43](Cl)Cl>C1COCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:12]3[CH2:13][N:14]([C:17](=[O:19])[CH3:18])[CH2:15][CH2:16][C:11]=3[N:10]([CH2:20][CH:21]([O:36][CH3:43])[CH2:22][N:23]3[CH2:28][CH2:27][N:26]([C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=4[CH3:35])[CH2:25][CH2:24]3)[N:9]=2)=[CH:6][CH:7]=1
Reactant: CC(=O)N1CCc2c(c(-c3ccc(Cl)cc3)nn2CC(O)CN2CCN(c3ccccc3C)CC2)C1
Reactant: ClCCl
Agent: [H-]
Agent: [Na+]
Solvent: CO
Solvent: CI
Solvent: C1CCOC1
Product: COC(CN1CCN(c2ccccc2C)CC1)Cn1nc(-c2ccc(Cl)cc2)c2c1CCN(C(C)=O)C2
Reaction time: 0.33 h

Procedure:
A stirred solution of 1-{3-(4-chloro-phenyl)-1-[2-hydroxy-3-(4-o-tolyl-piperazin-1-yl)-propyl]-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl}-ethanone (25 mg, 0.05 mmol) in THF (0.2 mL) was treated with NaH (1.42 mg, 0.06 mmol) at 25° C. After 20 min, methyl iodide (3.7 μL, 0.06 mmol) was added and the reaction mixture was stirred for an additional 2 h. Preparative TLC (silica, 5% MeOH/CH2Cl2) afforded 14.6 mg (56%) of a colorless film. TLC (silica, 10% MeOH/CH2Cl2): Rf=0.38. MS (electrospray): m/z 522.2 ([M+H]+, C29H36ClN5O2 requires 521.3). 1H NMR (CDCl3, 400 MHz, a mixture of two rotamers): 7.62 and 7.37 (AB pattern, Jab=8.8 Hz, 2H), 7.55 and 7.40 (AB pattern, Jab=8.8 Hz, 2H), 7.18-7.14 (m, 2H), 7.02-6.95 (m, 2H), 4.82 and 4.75 (AB pattern, Jab=15.5 Hz, 1H), 4.62 (s, 1H), 4.30-4.25 (m, 1H), 4.09-3.73 (m, 4H), 3.29 (s, 1.5H), 3.27 (s, 1.5H), 2.93-2.55 (m, 12H), 2.30 (s, 3H), 2.21 (s, 1.5H), 2.16 (s, 1.5H).
Reaction SMILES: Cl.[F:2][C:3]1[CH:4]=[C:5]([C@@H:14]([C:16]2[C:21]([F:22])=[CH:20][CH:19]=[CH:18][N:17]=2)[NH2:15])[CH:6]=[CH:7][C:8]=1[O:9][C:10]([F:13])([F:12])[F:11].[CH3:23][O:24][C:25]([C:27]1[CH:28]=[CH:29][C:30]([C:33](O)=[O:34])=[N:31][CH:32]=1)=[O:26].CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C>CN(C=O)C.O>[F:2][C:3]1[CH:4]=[C:5]([C@H:14]([NH:15][C:33]([C:30]2[CH:29]=[CH:28][C:27]([C:25]([O:24][CH3:23])=[O:26])=[CH:32][N:31]=2)=[O:34])[C:16]2[C:21]([F:22])=[CH:20][CH:19]=[CH:18][N:17]=2)[CH:6]=[CH:7][C:8]=1[O:9][C:10]([F:13])([F:12])[F:11]
Reactant: N[C@@H](c1ccc(OC(F)(F)F)c(F)c1)c1ncccc1F
Reactant: COC(=O)c1ccc(C(=O)O)nc1
Agent: CN(C)C(On1nnc2cccnc21)=[N+](C)C
Agent: Cl
Agent: F[P-](F)(F)(F)(F)F
Solvent: CN(C)C=O
Solvent: CCN(C(C)C)C(C)C
Solvent: O
Product: COC(=O)c1ccc(C(=O)N[C@@H](c2ccc(OC(F)(F)F)c(F)c2)c2ncccc2F)nc1
Temperature: 25 °C
Reaction time: 18 h

Procedure:
To a solution of (S)-(3-fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methanamine hydrochloride (17.0 g, 49.9 mmol, Intermediate 6) in DMF (166 mL, Aldrich) was added 5-(methoxycarbonyl)pyridine-2-carboxylic acid (9.94 g, 54.9 mmol, Oakwood Products, Inc.), HATU (20.87 g, 54.9 mmol, Accela ChemBio, Inc.), and DIPEA (18.23 mL, 105 mmol, EMD Biosciences, Inc.). The resulting mixture was then stirred at room temperature for 18 h. Water (400 mL) was then added and the mixture was extracted with EtOAc (2×200 mL). The combined organic extracts were dried over MgSO4 and concentrated in vacuo. The residue was then dissolved in MeOH (500 mL) and silica gel was added. The mixture was concentrated and dried in vacuo. The solid mixture was purified by silica gel flash column chromatography using ISCO instrument (solid loading, 0-100% EtOAc/hexane) to give the title compound as a white solid. MS (ESI, positive ion) m/z: 468 (M+H).
Reaction SMILES: C(O[CH2:4][CH2:5][CH2:6][C:7]1(O)[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[CH:11]=[CH:10][C:9]2[CH:18]=[CH:19][CH:20]=[CH:21][C:8]1=2)C.C(OC(=O)C)(=O)C.[IH:30].II>>[I:30][CH2:4][CH2:5][CH2:6][CH:7]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[CH:11]=[CH:10][C:9]2[CH:18]=[CH:19][CH:20]=[CH:21][C:8]1=2
Reactant: CCOCCCC1(O)c2ccccc2C=Cc2ccccc21
Reactant: I
Agent: II
Solvent: CC(=O)OC(C)=O
Product: ICCCC1c2ccccc2C=Cc2ccccc21
Temperature: 65 °C

Procedure:
A solution of 9.25 g. (0.0314 mole) of 5-(3-ethoxypropyl)-5-hydroxy-dibenzo[a,d]cycloheptene prepared as above in 45 ml. of acetic anhydride is heated on the steam-bath for 90 minutes then cooled to 65°C. A stream of nitrogen is passed through the solution while 30 ml. of hydriodic acid (sp. gr., 1.5) is added in portions, keeping the temperature below 90°C. The solution develops a dark brown iodine color during the addition. The solution is heated to 80°C. for 30 minutes, then cooled and poured into ice-water. The brown oil that separates is extracted into benzene and the extract washed with water, dilute sodium thiosulfate solution and finally with water. Evaporation of the benzene gives the product 5-(3-iodopropyl)-5H-dibenzo[a,d]cycloheptene as a yellow oil. A sample gives a precipitate with alcoholic silver nitrate solution.
Reaction SMILES: S(Cl)(Cl)=O.[F:5][C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][C:14]=1[CH3:15])[C:9]([OH:11])=[O:10].[C:16]1(C)C=CC=CC=1>>[CH3:16][O:10][C:9](=[O:11])[C:8]1[CH:12]=[CH:13][C:14]([CH3:15])=[C:6]([F:5])[CH:7]=1
Reactant: Cc1ccc(C(=O)O)cc1F
Reactant: Cc1ccccc1
Solvent: O=S(Cl)Cl
Product: COC(=O)c1ccc(C)c(F)c1
Temperature: 25 °C
Reaction time: 1.5 h
Yield: 83 %

Procedure:
Thionyl chloride (9.62 g, 81 mmol) was added to a solution of 3-fluoro-4-methylbenzoic acid (5.0 g, 32.4 mmol) in toluene (50 ml). The mixture was stirred at room temperature for 1.5 h and heated at reflux for 3 h. The sol-vent was removed in vacuo and the residue was taken up in methanol (30 ml) and CH2Cl2 (30 ml) and stirred for 18 h. The mixture was evaporated in vacuo and the residue was taken up in EtOAc (50 ml), washed with saturated NaHCO3 solution (3×75 ml), dried and evaporated in vacuo to yield the title compound (4.5 g, 83%).
Reaction SMILES: [OH:1][CH2:2][CH2:3][S:4][C:5]1[N:10]2[CH:11]=[CH:12][N:13]=[C:9]2[CH:8]=[CH:7][CH:6]=1.C(N(CC)CC)C.[CH3:21][N:22]=[C:23]=[O:24]>C(Cl)Cl>[CH3:21][NH:22][C:23]([O:1][CH2:2][CH2:3][S:4][C:5]1[N:10]2[CH:11]=[CH:12][N:13]=[C:9]2[CH:8]=[CH:7][CH:6]=1)=[O:24]
Reactant: CN=C=O
Reactant: OCCSc1cccc2nccn12
Solvent: ClCCl
Solvent: CCN(CC)CC
Product: CNC(=O)OCCSc1cccc2nccn12
Yield: 85.2 %

Procedure:
To a solution of 5-[2-(hydroxy)ethylthio]imidazo[1,2-a]pyridine (971 mg, 5 mmoles) and trietylamine (0.91 ml, 6.53 mmoles) in methylene chloride (40 ml) was added methyl isocyanate (0.65 ml, 11 mmoles) under ice-cooling with stirring and the mixture was stirred at room temperature for 12 hours. The reaction mixture was washed with saturated saline and dried over anhydrous magnesium sulfater. After the solvent was distilled off, the residue was purified by column chromatography (eluent: methanol/chloroform=1:20) to obtain 1.07 g of the desired product (85.2%, colorless crystals).
Reaction SMILES: Br[C:2]1[N:11]=[C:10]([C:12]2[NH:16][C:15]([CH2:17][C:18]3[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=3)=[N:14][N:13]=2)[C:9]([OH:25])=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2.[CH3:26][S:27]([OH:29])=[O:28].[Na].O>CN1CCCC1=O>[F:24][C:21]1[CH:22]=[CH:23][C:18]([CH2:17][C:15]2[NH:16][C:12]([C:10]3[C:9]([OH:25])=[C:8]4[C:3]([CH:4]=[CH:5][CH:6]=[N:7]4)=[C:2]([S:27]([CH3:26])(=[O:29])=[O:28])[N:11]=3)=[N:13][N:14]=2)=[CH:19][CH:20]=1
Reactant: CS(=O)O
Reactant: Oc1c(-c2nnc(Cc3ccc(F)cc3)[nH]2)nc(Br)c2cccnc12
Agent: [Na]
Solvent: O
Solvent: CN1CCCC1=O
Product: CS(=O)(=O)c1nc(-c2nnc(Cc3ccc(F)cc3)[nH]2)c(O)c2ncccc12
Yield: 37.6 %

Procedure:
A solution of 5-bromo-7-[5-(4-fluorobenzyl)-4H-1,2,4-triazol-3-yl]-1,6-naphthyridin-8-ol (9 mg, 0.02 mmol) and sodium methanesulfinic acid (100 mg) in 1-methylpyrrolidin-2-one (2 mL) was heated at 150° C. for 3 hours. The resultant solution was cooled to room temperature and water was added. The solids which formed were removed by filtration and further purified by preparative HPLC to give 7-[5-(4-fluorobenzyl)-4H-1,2,4-triazol-3-yl]-5-(methylsulfonyl)-1,6-naphthyridin-8-ol (3 mg, 33%) as a white solid. 1H NMR (CDCl3): δ 9.32 (d, J=8.4 Hz, 1 H), 9.25(d, J=4.4 Hz, 1 H), 7.75 (dd, J=8.4, 4.4 Hz, 1 H), 7.36 (dd, J=8.4, 5.6 Hz, 2 H), 7.03 (t, J=8.4 Hz, 2 H). 4.24 (s, 2 H), 3.42 (s, 3 H); MS m/z 400 (M+1).
Reaction SMILES: [CH2:1]([CH:14]1OCC[O:15]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]/[CH:7]=[CH:8]/[CH2:9][CH2:10][CH2:11][CH2:12][CH3:13].C1(C)C=CC(S(O)(=O)=O)=CC=1.O>CO>[CH:14](=[O:15])[CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]/[CH:7]=[CH:8]/[CH2:9][CH2:10][CH2:11][CH2:12][CH3:13]
Reactant: CCCCC/C=C/CCCCCCC1OCCO1
Agent: Cc1ccc(S(=O)(=O)O)cc1
Solvent: O
Solvent: CO
Product: CCCCC/C=C/CCCCCCC=O

Procedure:
0.89 g 2-[(E)tridec-7-enyl]-1,3-dioxolane (9), 30 mg p-toluenesulphonic acid and 25 ml of water were boiled in 75 ml methanol for 72 h under reflux under blanketing gas (86% conversion). The reaction mixture was extracted twice with 200 ml diethyl ether, washed with 30 ml sodium bicarbonate solution and dried over sodium sulphate and the solvent was distilled off under vacuum. Flash chromatography on silica gel gave (E)-8-tetradecenal (10) (E/Z ratio according to GC>97/3).
Reaction SMILES: [CH3:1][C:2]1[O:3][C:4]2[C:5](=[C:7]([OH:11])[CH:8]=[CH:9][CH:10]=2)[N:6]=1.[CH2:12]([O:14][C:15](=[O:19])[C:16]#[C:17][CH3:18])[CH3:13].C(=O)([O-])[O-].[K+].[K+]>O1CCCC1>[CH2:12]([O:14][C:15](=[O:19])/[CH:16]=[C:17](/[O:11][C:7]1[C:5]2[N:6]=[C:2]([CH3:1])[O:3][C:4]=2[CH:10]=[CH:9][CH:8]=1)\[CH3:18])[CH3:13]
Reactant: Cc1nc2c(O)cccc2o1
Reactant: CC#CC(=O)OCC
Agent: O=C([O-])[O-]
Agent: [K+]
Solvent: C1CCOC1
Product: CCOC(=O)/C=C(\C)Oc1cccc2oc(C)nc12
Temperature: 100 °C
Yield: 55.9 %

Procedure:
A mixture of 2-methyl-benzooxazol-4-ol (0.940 g, 6.30 mmol), ethyl-2-butynoate (4.24 g, 37.81 mmol) and potassium carbonate (0.956 g, 6.92 mmol) in tetrahydrofuran (20 mL) was placed in a sealed tube and heated at 100° C. for 5.5 h. The reaction mixture was cooled to room temperature, filtered and concentrated in vacuo. The residue was purified by ISCO Combiflash chromatography (Analogix SF-25, 2% to 15% ethyl acetate/hexanes) which afforded (E)-3-(2-methyl-benzooxazol-4-yloxy)-but-2-enoic acid ethyl ester (0.920 g, 56%) as a light yellow solid.
Reaction SMILES: Br[C:2]1[N:6]([CH3:7])[CH:5]=[N:4][C:3]=1[C:8]1[CH:13]=[C:12]([C:14]#[N:15])[CH:11]=[CH:10][N:9]=1.[F:16][C:17]([F:29])([F:28])[O:18][C:19]1[CH:24]=[CH:23][C:22](B(O)O)=[CH:21][CH:20]=1>>[CH3:7][N:6]1[C:2]([C:22]2[CH:21]=[CH:20][C:19]([O:18][C:17]([F:16])([F:28])[F:29])=[CH:24][CH:23]=2)=[C:3]([C:8]2[CH:13]=[C:12]([C:14]#[N:15])[CH:11]=[CH:10][N:9]=2)[N:4]=[CH:5]1
Reactant: Cn1cnc(-c2cc(C#N)ccn2)c1Br
Reactant: OB(O)c1ccc(OC(F)(F)F)cc1
Product: Cn1cnc(-c2cc(C#N)ccn2)c1-c1ccc(OC(F)(F)F)cc1

Procedure:
The title compound was prepared from 2-(5-bromo-1-methyl-1H-imidazol-4-yl)pyridine-4-carbonitrile and 4-(trifluoromethoxy)phenylboronic acid according to the procedure for the preparation of Example 3, part A. [M+H] Calc'd for C17H11F3N4O, 345. Found, 345.
Reaction SMILES: [C:1]1([C:7]2[O:11][C:10]([C:12]([N:14]3[CH2:17][CH:16]([O:18][C:19]4[CH:26]=[CH:25][C:22]([CH:23]=O)=[CH:21][CH:20]=4)[CH2:15]3)=[O:13])=[N:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(N(CC)CC)C.Cl.[CH2:35]1[C:39]2([CH2:43][CH2:42][NH:41][CH2:40]2)[CH2:38][CH2:37][O:36]1.[Na].C([O-])(O)=O.[Na+]>ClCCl>[CH2:35]1[C:39]2([CH2:43][CH2:42][N:41]([CH2:23][C:22]3[CH:21]=[CH:20][C:19]([O:18][CH:16]4[CH2:15][N:14]([C:12]([C:10]5[O:11][C:7]([C:1]6[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=6)=[N:8][N:9]=5)=[O:13])[CH2:17]4)=[CH:26][CH:25]=3)[CH2:40]2)[CH2:38][CH2:37][O:36]1
Reactant: O=Cc1ccc(OC2CN(C(=O)c3nnc(-c4ccccc4)o3)C2)cc1
Reactant: C1CC2(CCOC2)CN1
Agent: Cl
Agent: O=C([O-])O
Agent: [Na+]
Solvent: ClCCl
Solvent: CCN(CC)CC
Product: O=C(c1nnc(-c2ccccc2)o1)N1CC(Oc2ccc(CN3CCC4(CCOC4)C3)cc2)C1
Temperature: 25 °C
Reaction time: 0.5 h
Yield: 81.4 %

Procedure:
To a solution of 4-(1-(5-phenyl-1,3,4-oxadiazole-2-carbonyl)azetidin-3-yloxy)benzaldehyde (70 mg, 0.20 mmol) in dichloromethane (2 mL) was added triethylamine (0.100 mL, 0.72 mmol) and 2-oxa-7-azaspiro[4.4]nonane hydrochloride (77 mg, 0.47 mmol). The resulting mixture was stirred for 30 minutes at ambient temperature, after which was added sodium triacetoxyhydroborate (114 mg, 0.54 mmol). Stirring was continued at ambient temperature overnight, after which NaHCO3 (aq, sat, 5 ml) was added to the reaction mixture. The phases were separated using a phase separator. The aqueous phase was extracted twice with dichloromethane and dried with the aid of a phase separator. The combined organic phases were concentrated in vacuo to afford a colourless residue weighing 112 mg. The crude material was purified by preparative reverse-phase HPLC at pH 10 to give 75 mg (81%) of the desired product as a solid. 1H NMR (600 MHz, CDCl3): δ 1.75 (t, 2H), 1.79-1.89 (m, 2H), 2.32 (d, 1H), 2.45-2.49 (m, 2H), 2.59 (dd, 1H), 3.43 (d, 1H), 3.48-3.56 (m, 3H), 3.63-3.75 (m, 2H), 4.10 (dd, 1H), 4.56 (dd, 1H), 4.61-4.67 (m, 1H), 5.10 (dd, 1H), 5.16 (ddd, 1H), 6.86 (d, 2H), 7.26 (d, 2H), 7.63-7.73 (m, 3H), 8.06-8.11 (m, 2H). MS (APCI+) m/z 461.2 [M+H]+, LC purity: 97%