Reaction SMILES: [F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11]3[N:12]=[C:13]([NH:26][CH2:27][C:28]4[CH:33]=[CH:32][C:31]([S:34]([NH2:37])(=[O:36])=[O:35])=[CH:30][C:29]=4[C:38](F)(F)F)[N:14]=[C:15]([NH:18][C:19]4([C:22]([F:25])([F:24])[F:23])[CH2:21][CH2:20]4)[C:16]=3[N:17]=2)=[CH:4][CH:3]=1.ClC1C=C(CNC2N=C(NC3(C(F)(F)F)CC3)C3N=C(C4C=CC(F)=CC=4)C=CC=3N=2)C=CC=1S(N)(=O)=O.FC1C=C(CNC2N=C(NC3(C(F)(F)F)CC3)C3N=C(C4C=CC(F)=CC=4)C=CC=3N=2)C=CC=1S(N)(=O)=O.ClC1C=C(C(NC2N=C(NC3(C(F)(F)F)CC3)C3N=C(C4C=CC(F)=CC=4)C=CC=3N=2)C)C=CC=1S(N)(=O)=O.FC1C=C(CCNC2N=C(NC3(C(F)(F)F)CC3)C3N=C(C4C=CC(F)=CC=4)C=CC=3N=2)C=CC=1S(N)(=O)=O.ClC1C=CC(CNC2N=C(NC3(C(F)(F)F)CC3)C3N=C(C4C=CC(F)=CC=4)C=CC=3N=2)=CC=1S(N)(=O)=O.FC1C=C(S(N)(=O)=O)C=C(CNC2N=C(NC3(C(F)(F)F)CC3)C3N=C(C4C=CC(F)=CC=4)C=CC=3N=2)C=1.FC1C=CC(C2C=CC3N=C(NCC4C=CC(S(N)(=O)=O)=C(C(F)(F)F)C=4)N=C(NC4(C(F)(F)F)CC4)C=3N=2)=CC=1.FC1C=CC(C2C=CC3N=C(NCCC4C=CC(S(N)(=O)=O)=C(C(F)(F)F)C=4)N=C(NC4(C(F)(F)F)CC4)C=3N=2)=CC=1.FC1C=CC(CNC2N=C(NC3(C(F)(F)F)CC3)C3N=C(C4C=CC(F)=CC=4)C=CC=3N=2)=CC=1NS(C)(=O)=O.FC1C=CC(C2C=CC3N=C(NCC4C=CC(C(F)(F)F)=C(NS(C)(=O)=O)C=4)N=C(NC4(C(F)(F)F)CC4)C=3N=2)=CC=1.ClC1C=CC(CNC2N=C(NC3(C(F)(F)F)CC3)C3N=C(C4C=CC(F)=CC=4)C=CC=3N=2)=CC=1NS(C)(=O)=O.ClC1C=C(NS(C)(=O)=O)C=C(CNC2N=C(NC3(C(F)(F)F)CC3)C3N=C(C4C=CC(F)=CC=4)C=CC=3N=2)C=1.FC1C=CC(C2C=CC3N=C(NCC4C=C(NS(C)(=O)=O)C=C(C(F)(F)F)C=4)N=C(NC4(C(F)(F)F)CC4)C=3N=2)=CC=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[CH:10][C:11]3[N:12]=[C:13]([NH:26][CH2:27][C:28]4[CH:33]=[CH:32][C:31]([S:34]([NH2:37])(=[O:36])=[O:35])=[CH:30][C:29]=4[CH3:38])[N:14]=[C:15]([NH:18][C:19]4([C:22]([F:23])([F:25])[F:24])[CH2:21][CH2:20]4)[C:16]=3[N:17]=2)=[CH:6][CH:7]=1
Reactant: NS(=O)(=O)c1ccc(CNc2nc(NC3(C(F)(F)F)CC3)c3nc(-c4ccc(F)cc4)ccc3n2)c(C(F)(F)F)c1
Agent: CC(Nc1nc(NC2(C(F)(F)F)CC2)c2nc(-c3ccc(F)cc3)ccc2n1)c1ccc(S(N)(=O)=O)c(Cl)c1
Agent: CS(=O)(=O)Nc1cc(CNc2nc(NC3(C(F)(F)F)CC3)c3nc(-c4ccc(F)cc4)ccc3n2)cc(C(F)(F)F)c1
Agent: CS(=O)(=O)Nc1cc(CNc2nc(NC3(C(F)(F)F)CC3)c3nc(-c4ccc(F)cc4)ccc3n2)ccc1C(F)(F)F
Product: Cc1cc(S(N)(=O)=O)ccc1CNc1nc(NC2(C(F)(F)F)CC2)c2nc(-c3ccc(F)cc3)ccc2n1

Procedure:
4-{[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-3-trifluoromethyl-benzenesulfonamide; 2-Chloro-4-{[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide; 2-Fluoro-4-{[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide; 2-Chloro-4-{1-[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-ethyl}-benzenesulfonamide; 2-Fluoro-4-{[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-ethyl}-benzenesulfonamide; 2-Chloro-5-{[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide; 3-Fluoro-5-{[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide; 4-{[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-2-trifluoromethyl-benzenesulfonamide; 4-{[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-ethyl}-2-trifluoromethyl-benzenesulfonamide; N-(2-Fluoro-5-{[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-phenyl)-methanesulfonamide, N-(5-{[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-2-trifluoromethyl-phenyl)-methanesulfonamide; N-(2-Chloro-5-{[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-phenyl)-methanesulfonamide; N-(3-Chloro-5-{[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-phenyl)-methanesulfonamide; N-(3-{[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-5-trifluoromethyl-phenyl)-methanesulfonamide.