Reaction SMILES: [CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[CH:20]3[CH:15]([CH2:16][CH:17]=[CH:18][CH2:19]3)[C:14](=[O:21])[N:13]([CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][NH:27][CH2:28][CH2:29][CH:30]3[CH2:34][CH2:33][CH:32]([CH2:35][CH:36]([C:38]4[CH:43]=[C:42]([F:44])[CH:41]=[CH:40][C:39]=4[O:45][CH3:46])C)[O:31]3)[N:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].C1(OC2C=C(C3CN(CCCCCNCCC4CCC(CCC5C=C(F)C=CC=5OC)O4)C(=O)C3)C=CC=2OC)CCCC1.C1(OC2C=C(C3CN(CCCCCNCCC4CCC(CCCC5C=C(F)C=CC=5OC)O4)C(=O)C3)C=CC=2OC)CCCC1.COC1C=C(C2C3C(CC=CC3)C(=O)N(CCCCCNCCC(C3C=CC=CC=3)OC3C=CC(C(F)(F)F)=CC=3)N=2)C=CC=1OC.C1(OC2C=C(C3CN(CCCCCNCCC(C4C=CC=CC=4)OC4C=CC(C(F)(F)F)=CC=4)C(=O)C3)C=CC=2OC)CCCC1.COC1C=C(C2C3C(CC=CC3)C(=O)N(CCCCCNCCCC3(C4C=CC(F)=CC=4)CC4C=CC(C#N)=CC=4O3)N=2)C=CC=1OC.C1(OC2C=C(C3CN(CCCCCNCCCC4(C5C=CC(F)=CC=5)CC5C=CC(C#N)=CC=5O4)C(=O)C3)C=CC=2OC)CCCC1.COC1C=C(C2C3C(CC=CC3)C(=O)N(CCCCCNCC3CCC(C4C=CC(OC)=CC=4)O3)N=2)C=CC=1OC.C1(OC2C=C(C3CN(CCCCCNCC4CCC(C5C=CC(OC)=CC=5)O4)C(=O)C3)C=CC=2OC)CCCC1.C1(C2OC(CNCCCCCN3N=C(C4C=CC(OC)=C(OC)C=4)C4C(CC=CC4)C3=O)CC2)CCCCC1.C1(C2OC(CNCCCCCN3CC(C4C=CC(OC)=C(OC5CCCC5)C=4)CC3=O)CC2)CCCCC1.COC1C=C(C2C3C(CC=CC3)C(=O)N(CCCCCNCC3CCC(C4C=CC(C)=C(F)C=4)O3)N=2)C=CC=1OC.C1(OC2C=C(C3CN(CCCCCNCC4CCC(C5C=CC(C)=C(F)C=5)O4)C(=O)C3)C=CC=2OC)CCCC1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[CH:20]3[CH:15]([CH2:16][CH:17]=[CH:18][CH2:19]3)[C:14](=[O:21])[N:13]([CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][NH:27][CH2:28][CH2:29][CH:30]3[CH2:34][CH2:33][CH:32]([CH2:35][CH2:36][C:38]4[CH:43]=[C:42]([F:44])[CH:41]=[CH:40][C:39]=4[O:45][CH3:46])[O:31]3)[N:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]
Reactant: COc1ccc(C2=NN(CCCCCNCCC3CCC(CC(C)c4cc(F)ccc4OC)O3)C(=O)C3CC=CCC23)cc1OC
Agent: COc1ccc(C2=NN(CCCCCNCC3CCC(C4CCCCC4)O3)C(=O)C3CC=CCC23)cc1OC
Agent: COc1ccc(C2=NN(CCCCCNCC3CCC(c4ccc(C)c(F)c4)O3)C(=O)C3CC=CCC23)cc1OC
Agent: COc1ccc(C2=NN(CCCCCNCCC(Oc3ccc(C(F)(F)F)cc3)c3ccccc3)C(=O)C3CC=CCC23)cc1OC
Product: COc1ccc(F)cc1CCC1CCC(CCNCCCCCN2N=C(c3ccc(OC)c(OC)c3)C3CC=CCC3C2=O)O1

Procedure:
Similar methods were used to prepare 4-(3,4-Dimethoxyphenyl)-2-[5-(2-{5-[2-(5-fluoro-2-methoxyphenyl)-propyl]-tetrahydrofuran-2-yl}-ethylamino)-pentyl]-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one, 4-(3-Cyclopentyloxy-4-methoxy-phenyl)-1-[5-(2-{5-[2-(5-fluoro-2-methoxy-phenyl)-ethyl]-tetrahydro-furan-2-yl}-ethylamino)-pentyl]-pyrrolidin-2-one, 4-(3-Cyclopentyloxy-4-methoxy-phenyl)-1-[5-(2-{5-[3-(5-fluoro-2-methoxy-phenyl)-propyl]-tetrahydro-furan-2-yl}-ethylamino)-pentyl]-pyrrolidin-2-one, 4-(3,4-Dimethoxy-phenyl)-2-{5-[3-phenyl-3-(4-trifluoromethyl-phenoxy)-propylamino]-pentyl}-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one, 4-(3-Cyclopentyloxy-4-methoxy-phenyl)-1-{5-[3-phenyl-3-(4-trifluoromethyl-phenoxy)-propylamino]-pentyl}-pyrrolidin-2-one, 2-(3-{5-[4-(3,4-Dimethoxy-phenyl)-1-oxo-4a,5,8,8a-tetrahydro-1H-phthalazin-2-yl]-pentylamino}-propyl)-2-(4-fluoro-phenyl)-2,3-dihydro-benzofuran-6-carbonitrile, 2-(3-{5-[4-(3-Cyclopentyloxy-4-methoxy-phenyl)-2-oxo-pyrrolidin-1-yl]-pentylamino}-propyl)-2-(4-fluoro-phenyl)-2,3-dihydro-benzofuran-6-carbonitrile, 4-(3,4-Dimethoxy-phenyl)-2-(5-{[5-(4-methoxy-phenyl)-tetrahydro-furan-2-ylmethyl]-amino}-pentyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one, 4-(3-Cyclopentyloxy-4-methoxy-phenyl)-1-(5-{[5-(4-methoxy-phenyl)-tetrahydro-furan-2-ylmethyl]-amino}-pentyl)-pyrrolidin-2-one, 2-{5-[(5-Cyclohexyl-tetrahydro-furan-2-ylmethyl)-amino]-pentyl}-4-(3,4-dimethoxy-phenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one, 1-{5-[(5-Cyclohexyl-tetrahydro-furan-2-ylmethyl)-amino]-pentyl}-4-(3-cyclopentyloxy-4-methoxy-phenyl)-pyrrolidin-2-one, 4-(3,4-Dimethoxy-phenyl)-2-(5-{[5-(3-fluoro-4-methyl-phenyl)-tetrahydro-furan-2-ylmethyl]-amino}-pentyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one, 4-(3-Cyclopentyloxy-4-methoxy-phenyl)-1-(5-{[5-(3-fluoro-4-methyl-phenyl)-tetrahydro-furan-2-ylmethyl]-amino}-pentyl)-pyrrolidin-2-one.