Reaction SMILES: BrC1C=C2C(=O)C3C(=CC=C(I)C=3)OC2=NC=1.[Cl-].C(OC(=O)C[Zn+])(C)(C)C.BrC1C=C2C(CC(OC(C)(C)C)=O)(O)C3C(=CC=C(I)C=3)OC2=NC=1.N([Si](C)(C)C)=[N+]=[N-].B(F)(F)F.[N:64]([C:67]1([CH2:83][C:84](OC(C)(C)C)=[O:85])[C:80]2[C:75](=[N:76][CH:77]=[C:78]([Br:81])[CH:79]=2)[O:74][C:73]2[C:68]1=[CH:69][C:70]([I:82])=[CH:71][CH:72]=2)=[N+]=[N-].[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1.C1(C)C=CC=CC=1.C(O[Ti](OCC)(OCC)OCC)C.CCOCC>[NH2:64][C:67]1([CH2:83][CH2:84][OH:85])[C:80]2[C:75](=[N:76][CH:77]=[C:78]([Br:81])[CH:79]=2)[O:74][C:73]2[C:68]1=[CH:69][C:70]([I:82])=[CH:71][CH:72]=2
Reactant: CC(C)(C)OC(=O)CC1(N=[N+]=[N-])c2cc(I)ccc2Oc2ncc(Br)cc21
Agent: CCO[Ti](OCC)(OCC)OCC
Agent: CC(C)(C)OC(=O)CC1(O)c2cc(I)ccc2Oc2ncc(Br)cc21
Agent: CC(C)(C)OC(=O)C[Zn+]
Solvent: Cc1ccccc1
Solvent: C1CCOC1
Solvent: CCOCC
Product: NC1(CCO)c2cc(I)ccc2Oc2ncc(Br)cc21
Temperature: 0 °C
Reaction time: 0.5 h
Yield: 37.4 %

Procedure:
3-Bromo-7-iodo-5H-chromeno[2,3-b]pyridin-5-one (6.0 g, 14.93 mmol) was taken up in THF (150 mL). Neat tetraethoxytitanium (9.29 mL, 44.8 mmol) was added. An ether solution of (2-tert-butoxy-2-oxoethyl)zinc(II) chloride (0.5 M, 62.7 mL, 31.3 mmol) was added via cannula. The reaction was stirred at 0° C. for 30 min, then was warmed to rt and stirred 30 min. Excess organozinc reagent was quenched at 0° C. with 250 mL of half-saturated brine. The mixture was filtered through Celite, rinsing the solid with EtOAc (700 mL). The resulting filtrate's organic layer was separated and extracted further with saturated brine (50 mL), then was dried over sodium sulfate and concentrated. The crude tert-butyl 2-(3-bromo-5-hydroxy-7-iodo-5H-chromeno[2,3-b]pyridin-5-yl)acetate (7.8 g) was used in the next step without further purification. Step 2: In a 1-L flask, the tert-butyl 2-(3-bromo-5-hydroxy-7-iodo-5H-chromeno[2,3-b]pyridin-5-yl)acetate (7.8 g, 15.05 mmol) was suspended in toluene (100 mL). Neat azidotrimethylsilane (2.99 mL, 22.58 mmol) was added. The mixture was cooled to 0° C., and BF3-etherate (2.098 mL, 16.56 mmol) was added. The mixture was allowed to warm naturally in the ice bath. After two hours, the mixture was quenched with MeOH (3 mL), then with half-saturated aqueous NaHCO3 (100 mL). The residue was extracted with 10% MeOH-EtOAc (3×200 mL). The organics were combined, washed with saturated brine (50 mL), dried over sodium sulfate and concentrated. The crude tert-butyl 2-(5-azido-3-bromo-7-iodo-5H-chromeno[2,3-b]pyridin-5-yl)acetate was used in the next step without further purification (7.27 g). Step 3: In a 1-L flask, the tert-butyl 2-(5-azido-3-bromo-7-iodo-5H-chromeno[2,3-b]pyridin-5-yl)acetate (7.27 g, 13.38 mmol) was suspended in THF (100 mL) and the suspension was cooled to 0° C. A THF solution of LAH (1 M, 20.08 mL, 20.08 mmol) was added. After 30 min, the reaction mixture was quenched with careful addition of water (0.75 mL), 4 M aqueous NaOH (2.2 mL), and water (0.75 mL). The mixture was filtered through Celite, rinsing with THF (60 mL), then with EtOAc (150 mL). The combined filtrate was concentrated. The residue was purified through silica gel (400 mL) which had been deactivated with Et3N (40 mL), using 100:100:1 EtOAc-hexane-Et3N, to afford 2-(5-amino-3-bromo-7-iodo-5H-chromeno[2,3-b]pyridin-5-yl)ethanol (2.24 g). Step 4: In a 250-mL flask, the 2-(5-amino-3-bromo-7-iodo-5H-chromeno[2,3-b]pyridin-5-yl)ethanol (2.24 g, 5.01 mmol) was dissolved in THF (30 mL). Benzoyl isothiocyanate (0.607 mL, 4.51 mmol) was added. After 1 h, the mixture was concentrated. The residue was taken up in ACN (30 mL), and catalytic TEA (0.069 mL, 0.501 mmol) was added, followed by DCC (1.137 g, 5.51 mmol). A water-cooled condenser was affixed, and the solution was stirred in an 80° C. oil bath for 2 h. The reaction was then concentrated. The residue was used directly in the next step without further purification. Step 5: In a 150-mL resealable vessel, the crude N-(3-bromo-7-iodo-5′,6′-dihydrospiro[chromeno[2,3-b]pyridine-5,4′-[1,3]oxazine]-2′-yl)benzamide from the above procedure was dissolved in 1:1 THF-MeOH (12 mL). Aqueous NaOH (12.04 mL, 30.1 mmol) was added. The vessel was sealed and heated in a 90° C. oil bath. After 2 h, the reaction was concentrated to remove most of the THF and MeOH. The aqueous residue was diluted with water (35 mL), and the aqueous layer was extracted with 5% MeOH-dcm (3×100 mL). The organics were combined, washed with dilute brine (35 mL), dried over sodium sulfate and concentrated. The residue was purified through silica gel (300 mL) using 3% MeOH-dcm, to afford intermediate 25 (3-bromo-7-iodo-5′,6′-dihydrospiro[chromeno[2,3-b]pyridine-5,4′-[1,3]oxazin]-2′-amine) (1.99 g). MS (m/z) 472/474 (M+H)+.