Reaction SMILES: [CH3:1][C@H:2]1[O:7][C@@H:6]([O:8][CH:9]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=[CH:36][CH:35]([CH3:50])[CH:34]([CH:51]([CH2:53][CH2:54][CH:55]([OH:67])[CH2:56][C:57]([C:59]3[CH:64]=[CH:63][C:62]([NH:65]C)=[CH:61][CH:60]=3)=[O:58])[CH3:52])[O:33][C:31](=[O:32])[CH2:30][CH:29]([OH:68])[CH2:28][C:26](=[O:27])[CH2:25][CH:24]([OH:69])[CH2:23][CH:22]([OH:70])[CH2:21][CH:20]([OH:71])[CH2:19][CH:18]([OH:72])[CH2:17][C:15]3([OH:73])[O:16][CH:11]([CH:12]([C:75]([O:77][CH3:78])=[O:76])[CH:13]([OH:74])[CH2:14]3)[CH2:10]2)[C@@H:5]([OH:79])[C@@H:4]([NH2:80])[C@@H:3]1[OH:81].CC[C@@H]([C@H](N)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)[C@H](CC)C)=O)C(C)C)=O)CCCCN)=O)CCCCN)=O)C(C)C)=O)C)=O)CC(O)=O)=O)CC(C)C)=O)[C@H](CC)C)=O)C)=O)CCCCN)=O)CC1C2C(=CC=CC=2)NC=1)=O)CCCCN)=O)C.CC[C@@H]([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](N)CC(C)C)=O)CCCCN)=O)CC(C)C)=O)CCCCN)=O)CO)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CC(C)C)=O)C(C)C)=O)CCCCN)=O)CCCCN)=O)C)=O)CC1C2C(=CC=CC=2)NC=1)=O)CO)=O)C(C)C)=O)C>>[CH3:1][C@H:2]1[O:7][C@@H:6]([O:8][CH:9]2[CH2:10][CH:11]3[O:16][C:15]([OH:73])([CH2:17][CH:18]([OH:72])[CH2:19][CH:20]([OH:71])[CH2:21][CH:22]([OH:70])[CH2:23][CH:24]([OH:69])[CH2:25][C:26]([CH2:28][CH:29]([OH:68])[CH2:30][C:31]([O:33][CH:34]([CH:51]([CH2:53][CH2:54][CH:55]([OH:67])[CH2:56][C:57]([C:59]4[CH:60]=[CH:61][C:62]([NH2:65])=[CH:63][CH:64]=4)=[O:58])[CH3:52])[CH:35]([CH3:50])[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=[CH:47][CH:48]=[CH:49]2)=[O:32])=[O:27])[CH2:14][CH:13]([OH:74])[CH:12]3[C:75]([O:77][CH3:78])=[O:76])[C@@H:5]([OH:79])[C@@H:4]([NH2:80])[C@@H:3]1[OH:81]
Reactant: CNc1ccc(C(=O)CC(O)CCC(C)C2OC(=O)CC(O)CC(=O)CC(O)CC(O)CC(O)CC(O)CC3(O)CC(O)C(C(=O)OC)C(CC(O[C@@H]4O[C@H](C)[C@@H](O)[C@H](N)[C@@H]4O)C=CC=CC=CC=CC=CC=CC=CC2C)O3)cc1
Agent: CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@H](C(N)=O)[C@@H](C)CC)C(C)C)C(C)C)[C@@H](C)CC
Agent: CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)C(C)C
Agent: COC(=O)C1C(O)CC2(O)CC(O)CC(O)CC(O)CC(O)CC(=O)CC(O)CC(=O)OC(C(C)CCC(O)CC(=O)c3ccc(N)cc3)C(C)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C(O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)CC1O2
Product: COC(=O)C1C(O)CC2(O)CC(O)CC(O)CC(O)CC(O)CC(=O)CC(O)CC(=O)OC(C(C)CCC(O)CC(=O)c3ccc(N)cc3)C(C)C=CC=CC=CC=CC=CC=CC=CC(O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)CC1O2

Procedure:
A typical chromatograph of mepartricins, SPA-222 and SPA-160 is presented in FIG. 2 a and b respectively. Two major peaks were obtained with both the analogues which correspond to Mepartricin A and B (Golik et al, (1980) J. Antibiot 33 904. The retention times of MP-A and MP-B were 8:5 min and 13:5 min. respectively. The purity of MP-A and B complex was observed to be in the range of 68 to 74%.