Reaction SMILES: CN(C)CC(N1C2C(=CC(OC)=C(NC3N4C(=NC5C(C4=O)=C(F)C(F)=CC=5)C4C=CN(S(C5C=CC(C)=CC=5)(=O)=O)C=4N=3)C=2)CCC1)=O.CC(N)C.[CH3:54][N:55]([CH3:106])[CH2:56][C:57]([N:59]1[C:68]2[C:63](=[CH:64][C:65]([O:104][CH3:105])=[C:66]([NH:69][C:70]3[N:71]=[C:72]([NH:89][C:90]4[C:95]([C:96]([NH:98][CH:99]([CH3:101])[CH3:100])=[O:97])=[C:94]([F:102])[C:93]([F:103])=[CH:92][CH:91]=4)[C:73]4[CH:78]=[CH:77][N:76](S(C5C=CC(C)=CC=5)(=O)=O)[C:74]=4[N:75]=3)[CH:67]=2)[CH2:62][CH2:61][CH2:60]1)=[O:58].[OH-].[Na+]>C1COCC1.C(OCC)(=O)C.O1CCOCC1.O>[CH3:106][N:55]([CH3:54])[CH2:56][C:57]([N:59]1[C:68]2[C:63](=[CH:64][C:65]([O:104][CH3:105])=[C:66]([NH:69][C:70]3[NH:75][C:74]4=[N:76][CH:77]=[CH:78][C:73]4=[C:72]([NH:89][C:90]4[C:95]([C:96]([NH:98][CH:99]([CH3:101])[CH3:100])=[O:97])=[C:94]([F:102])[C:93]([F:103])=[CH:92][CH:91]=4)[N:71]=3)[CH:67]=2)[CH2:62][CH2:61][CH2:60]1)=[O:58]
Reactant: COc1cc2c(cc1Nc1nc(Nc3ccc(F)c(F)c3C(=O)NC(C)C)c3ccn(S(=O)(=O)c4ccc(C)cc4)c3n1)N(C(=O)CN(C)C)CCC2
Agent: COc1cc2c(cc1Nc1nc3c(ccn3S(=O)(=O)c3ccc(C)cc3)c3nc4ccc(F)c(F)c4c(=O)n13)N(C(=O)CN(C)C)CCC2
Agent: [Na+]
Agent: [OH-]
Solvent: O
Solvent: CC(C)N
Solvent: C1COCCO1
Product: COc1cc2c(cc1Nc1nc(Nc3ccc(F)c(F)c3C(=O)NC(C)C)c3ccnc-3[nH]1)N(C(=O)CN(C)C)CCC2
Temperature: 25 °C
Reaction time: 2 h

Procedure:
To a solution of 5-{[1-(N,N-dimethylglycyl)-6-(methyloxy)-1,2,3,4-tetrahydro-7-quinolinyl]amino}-8,9-difluoro-3-[(4-methylphenyl)sulfonyl]pyrrolo[2′,3′:4,5]pyrimido[6,1-b]quinazolin-7(3H)-one (300 mg, 0.436 mmol) in THF (5 mL) was added (1-methylethyl)amine (1.4 mL, 17.44 mmol). The resulting mixture was let stir at rt for 2 h at which time it was diluted with ethyl acetate and washed with water and a saturated brine solution. Organics were dried over sodium sulfate and solvents removed under reduced pressure. The residue was attempted to be purified via chromatography on SiO2 and afforded a yellow solid containing about 50% 6-({2-{[1-(N,N-dimethylglycyl)-6-(methyloxy)-1,2,3,4-tetrahydro-7-quinolinyl]amino}-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)-2,3-difluoro-N-(1-methylethyl)benzamide mmol) as a yellow solid. This crude material was dissolved in 1,4-dioxane (6 mL) and transferred to a 20 ml microwave vessel. Water (2 mL) and a solution of 6M NaOH (2 ml) was added and reaction mixture heated in microwave at 120° C. for 10 minutes. Resulting brown solution was diluted with ethyl acetate and washed with a saturated sodium bicarbonate solution, water and a saturated brine solution. Organics were dried over sodium sulfate and solvents removed under reduced pressure to afford a brown solid that was purified via chromatography on SiO2 to afford 6-[(2-{[1-(N,N-dimethylglycyl)-6-(methyloxy)-1,2,3,4-tetrahydro-7-quinolinyl]amino}-1H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-2,3-difluoro-N-(1-methylethyl)benzamide (42 mg, 0.071 mmol) as an off white solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.00 (d, J=6.59 Hz, 6 H) 1.81-1.92 (m, 2 H) 2.12 (br. s., 6 H) 2.60-2.73 (m, 2 H) 3.24 (s, 2 H) 3.69 (t, J=6.04 Hz, 2 H) 3.83 (s, 3 H) 3.90-4.03 (m, 1 H) 6.34 (d, J=0.92 Hz, 1 H) 6.81 (br. s., 1 H) 6.91-6.99 (m, 1 H) 7.38-7.51 (m, 2 H) 7.74-7.87 (m, 1 H) 8.41 (d, J=7.69 Hz, 2 H), 9.29 (s, 1 H) 11.30 (br. s., 1 H) (ESIMS (M+H)+=593)