Azzindani/Open_Reaction_Data huggingface dataset:
Reaction SMILES: [CH3:1][C:2]1[N:3]=[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)[N:5]2[C:10]=1[CH:9]=[N:8][C:7]([NH2:11])=[N:6]2.I[C:23]1[CH:24]=[C:25]([CH:35]=[CH:36][CH:37]=1)[CH2:26][NH:27][C:28](=[O:34])[O:29][C:30]([CH3:33])([CH3:32])[CH3:31].C(P(C(C)(C)C)C1C=CC=CC=1C1C=CC=CC=1)(C)(C)C.CC([O-])(C)C.[Na+]>O1CCOCC1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>[CH3:1][C:2]1[N:3]=[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:19])[F:20])[CH:13]=2)[N:5]2[C:10]=1[CH:9]=[N:8][C:7]([NH:11][C:23]1[CH:24]=[C:25]([CH:35]=[CH:36][CH:37]=1)[CH2:26][NH:27][C:28](=[O:34])[O:29][C:30]([CH3:32])([CH3:33])[CH3:31])=[N:6]2
Reactant: Cc1nc(-c2cccc(C(F)(F)F)c2)n2nc(N)ncc12
Reactant: CC(C)(C)OC(=O)NCc1cccc(I)c1
Agent: [Pd]
Agent: CC(C)(C)P(c1ccccc1-c1ccccc1)C(C)(C)C
Agent: CC(C)(C)[O-]
Solvent: C1COCCO1
Product: Cc1nc(-c2cccc(C(F)(F)F)c2)n2nc(Nc3cccc(CNC(=O)OC(C)(C)C)c3)ncc12
Yield: 31.2 %

Procedure:
In a similar manner as described for Example 41, 5-methyl-7-[3-(trifluoromethyl)phenyl]imidazo[5,1-f][1,2,4]triazin-2-amine (Intermediate 45) (0.025 g, 0.09 mmol), tert-butyl 3-iodobenzylcarbamate (0.028 g, 0.09 mmol), Pd2(dba)3 (0.008 g, 0.01 mmol), 2-(Di-t-butylphosphino)biphenyl (0.008 g, 0.03 mmol), and NaOtBu (0.011 g, 0.11 mmol) in 1,4-dioxane (1 mL) gave tert-butyl 3-({5-methyl-7-[3-(trifluoromethyl)phenyl]imidazo[5,1-f][1,2,4]triazin-2-yl}amino)benzylcarbamate (0.014 g) as a yellow solid. 1H NMR (CDCl3): δ8.82 (s, 1H), 8.80 (s, 1H), 8.66 (d, J=7.3 Hz, 1H), 7.79-7.73 (m, 1H), 7.70-7.60 (m, 2H), 7.42-7.28 (m, 4H), 7.18 (bs, 1H), 7.04 (d, J=7.7 Hz, 1H), 4.32 (bs, 2H), 2.61 (s, 3H), 1.46 (s, 9H). MS m/z 499 (M+1).
Reaction SMILES: Br[C:2]1[N:6]2[C:7]3[C:12]([N:13]=[C:14]([CH3:15])[C:5]2=[C:4]([CH3:17])[N:3]=1)=[CH:11][CH:10]=[C:9]([F:16])[CH:8]=3.[CH3:18][C:19]1[CH:20]=[C:21](B(O)O)[CH:22]=[CH:23][CH:24]=1.C([O-])([O-])=O.[K+].[K+]>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[F:16][C:9]1[CH:8]=[C:7]2[C:12]([N:13]=[C:14]([CH3:15])[C:5]3[N:6]2[C:2]([C:23]2[CH:22]=[CH:21][CH:20]=[C:19]([CH3:18])[CH:24]=2)=[N:3][C:4]=3[CH3:17])=[CH:11][CH:10]=1
Reactant: Cc1cccc(B(O)O)c1
Reactant: Cc1nc(Br)n2c1c(C)nc1ccc(F)cc12
Agent: c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1
Agent: O=C([O-])[O-]
Agent: [K+]
Product: Cc1cccc(-c2nc(C)c3c(C)nc4ccc(F)cc4n23)c1
Yield: 91.7 %

Procedure:
Following the general Suzuki coupling procedure, reaction of bromide 5A (75 mg, 0.25 mmol), 3-methylphenylboronic acid (42 mg, 0.30 mmol), K2CO3 (105 mg, 0.75 mmol) and Pd(PPh3)4 (5.8 mg, 0.005 mmol) provided the coupling product as a white powder (70 mg, 92% yield). EIMS 306.1 [M+H]+.
Reaction SMILES: C(P(C(C)(C)C)C(C)(C)C)(C)(C)C.CCCCCC.Br[C:21]1[CH:22]=[C:23]2[C:28](=[CH:29][CH:30]=1)[N:27]([CH2:31][CH2:32][N:33]([CH3:37])[CH2:34][CH2:35][OH:36])[CH2:26][CH2:25][CH2:24]2.C[Si]([N-:42][Si](C)(C)C)(C)C.[Li+]>C1COCC1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>[NH2:42][C:21]1[CH:22]=[C:23]2[C:28](=[CH:29][CH:30]=1)[N:27]([CH2:31][CH2:32][N:33]([CH3:37])[CH2:34][CH2:35][OH:36])[CH2:26][CH2:25][CH2:24]2
Reactant: CN(CCO)CCN1CCCc2cc(Br)ccc21
Reactant: C[Si](C)(C)[N-][Si](C)(C)C
Agent: [Pd]
Agent: CC(C)(C)P(C(C)(C)C)C(C)(C)C
Agent: O=C(/C=C/c1ccccc1)/C=C/c1ccccc1
Solvent: CCCCCC
Solvent: C1CCOC1
Product: CN(CCO)CCN1CCCc2cc(N)ccc21
Temperature: 25 °C
Reaction time: 0.08 h
Yield: 43.4 %

Procedure:
A suspension of tris(dibenzylideneacetone)dipalladium(0) (48 mg, 0.053 mmol) in anhydrous THF (3 mL) was treated with tri-t-butylphosphine in hexane (10% wt) (0.320 mL, 0.105 mmol) and the mixture stirred for 5 minutes at room temperature. A solution of 2-((2-(6-bromo-3,4-dihydroquinolin-1(2H)-yl)ethyl)(methyl)amino)ethanol (compound 2, 0.165 g, 0.527 mmol) in THF (7 mL) was added followed by lithium bis(trimethylsilyl)amide (1M in THF, 1.58 mL, 1.58 mmol) and the mixture heated in a sealed reaction vial at 90° C. for 3 hours. The mixture was cooled to room temperature then to 0° C. and quenched with 3N aq. HCl (1.5 mL) and stirred for 30 minutes slowly warming to room temperature. The mixture was diluted with ethyl acetate, basified to pH ˜10 by the addition of 1N aq NaOH and transferred to a separatory funnel. The organic layer was separated and the aqueous layer further extracted with ethyl acetate (×3) and the combined organic layers washed with brine, dried over Na2SO4, filtered and concentrated to give a dark brown residue. Purification on silica gel eluting with 7.5% 2M NH3 in methanol/92.5% dichloromethane yielded an orange-red residue, 3 (57 mg, 43.4%). 1H-NMR (DMSO-d6) δ 6.36-6.27 (m, 2H), 6.21 (br s, 1H), 4.31 (t, 1H, J=5.4 Hz, exch. D2O), 4.18 (br s, 2H, exch. D2O), 3.44 (q, 2H, J=6.3 Hz), 3.18 (t, 2H, J=7.3 Hz), 3.10 (t, 2H, J=5.3 Hz), 2.56-2.40 (2×m, 6H), 2.22 (s, 3H), 1.84-1.72 (m, 2H). MS (ESI+): 250 (MH+, 100).
Reaction SMILES: [C:1]([O:5][C:6](=[O:15])[C:7]1[CH:12]=[CH:11][C:10]([C:13]#[CH:14])=[CH:9][CH:8]=1)([CH3:4])([CH3:3])[CH3:2].[Br:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1I.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>C(NCC)C.C(#N)C.Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[Cu]I>[C:1]([O:5][C:6]([C:7]1[CH:8]=[CH:9][C:10]([C:13]#[C:14][C:20]2[CH:21]=[CH:22][C:17]([Br:16])=[CH:18][CH:19]=2)=[CH:11][CH:12]=1)=[O:15])([CH3:4])([CH3:3])[CH3:2]
Reactant: Brc1ccccc1I
Reactant: C#Cc1ccc(C(=O)OC(C)(C)C)cc1
Agent: Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1
Agent: [Cu]I
Agent: c1ccc(P(c2ccccc2)c2ccccc2)cc1
Solvent: CCNCC
Solvent: CC#N
Product: CC(C)(C)OC(=O)c1ccc(C#Cc2ccc(Br)cc2)cc1
Temperature: 40 °C
Reaction time: 72 h

Procedure:
2.8 g (Ph3P)2PdCl2 and 400 mg of CuI are added to a solution of 40.4 g of 4-ethinyl-benzoic acid tert.-butyl ester, 56.6 g of bromoiodobenzene and 1.34 g of Ph3P in 50 ml of diethylamine and 300 ml of absolute acetonitrile and the reaction mixture is stirred for 72 hours at 40° C., suction filtered and dried.
Reaction SMILES: C([SnH](CCCC)CCCC)CCC.[OH:14][N:15]1[C:20]([CH3:22])([CH3:21])[CH2:19][C:18](=[O:23])[CH2:17][C:16]1([CH3:25])[CH3:24].[CH:26]1(I)[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1.CCCCCCC.C(OCC)(=O)C>ClC1C=CC=CC=1>[CH:26]1([O:14][N:15]2[C:20]([CH3:21])([CH3:22])[CH2:19][C:18](=[O:23])[CH2:17][C:16]2([CH3:25])[CH3:24])[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1
Reactant: CC1(C)CC(=O)CC(C)(C)N1O
Reactant: IC1CCCCC1
Agent: CCCC[SnH](CCCC)CCCC
Solvent: Clc1ccccc1
Solvent: CCCCCCC
Solvent: CCOC(C)=O
Product: CC1(C)CC(=O)CC(C)(C)N1OC1CCCCC1

Procedure:
Tributyltin hydride is added to a solution of excess 1-oxyl-2,2,6,6-tetramethylpiperidin-4-one and cyclohexyl iodide in chlorobenzene. The mixture is passed through silica gel with heptane/ethyl acetate to obtain 1-cyclohexyloxy-2,2,6,6-tetramethylpiperidin-4-one, which is free of any bis(4-oxo-2,2,6,6-tetramethylpiperidin-1-yloxy)cyclohexane bridged material.
Reaction SMILES: C1C2C(=CC=CC=2)CCC1.[CH:11]1([C:21]([OH:23])=O)[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:14][CH2:13][CH2:12]1.S(Cl)([Cl:26])=O>>[C@@H:11]1([C:21]([Cl:26])=[O:23])[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:14][CH2:13][CH2:12]1
Reactant: O=S(Cl)Cl
Reactant: O=C(O)C1CCCc2ccccc21
Solvent: c1ccc2c(c1)CCCC2
Product: O=C(Cl)[C@H]1CCCc2ccccc21

Procedure:
According to Route A, 1,2,3,4-tetrahydronaphthalene (Compound VI) is converted into 1,2,3,4-tetrahydro-1-naphthoic acid (Compound VII), which is optically resolved to obtain the S-enantiomer (Compound VIIA). The optically enriched acid then is reacted with thionyl chloride to afford (S)-1,2,3,4-tetrahydro-1-naphthoyl chloride (Compound VIIIA). This acid chloride is reacted with Compound III to afford N-(1-azabicyclo[2.2.2]oct-3S-yl)-(1,2,3,4-tetrahydronaphthalen-1S-ylmethyl)amine (Compound IXA), which subsequently is converted to palonosetron hydrochloride over several steps.
Reaction SMILES: C([O:8][C:9](=[O:38])[CH:10]([NH:27]C(OCC1C=CC=CC=1)=O)[CH2:11][O:12][C:13]([O:15][CH:16]([CH3:26])[CH2:17][CH2:18][CH2:19][CH:20]([CH3:25])[CH2:21][CH:22]([CH3:24])[CH3:23])=[O:14])C1C=CC=CC=1>[Pd].CO>[NH2:27][CH:10]([CH2:11][O:12][C:13]([O:15][CH:16]([CH3:26])[CH2:17][CH2:18][CH2:19][CH:20]([CH3:25])[CH2:21][CH:22]([CH3:24])[CH3:23])=[O:14])[C:9]([OH:38])=[O:8]
Reactant: CC(C)CC(C)CCCC(C)OC(=O)OCC(NC(=O)OCc1ccccc1)C(=O)OCc1ccccc1
Agent: [Pd]
Solvent: CO
Product: CC(C)CC(C)CCCC(C)OC(=O)OCC(N)C(=O)O
Yield: 97.3 %

Procedure:
A mixture of 4.81 g 2-benzyloxycarbonylamino-3-(1,5,7-trimethyl-octyloxycarbonyloxy)-propionic acid benzyl ester, 250 ml methanol and a catalytic amount of 10% Pd/C was stirred six hours under an atmosphere of hydrogen. Filtration over Celite and evaporation under reduced pressure gave 2.69 g of colorless crystals.
Reaction SMILES: [C:1]12([C:11](=[O:21])[CH2:12][N:13]3[CH2:20][CH2:19][CH2:18][C@H:14]3[C:15]([OH:17])=O)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[CH2:22]([NH:29][C:30](=[O:40])[C@H:31]([CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)[NH2:32])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1.C(N(CC)CC)C>ClCCl>[C:1]12([C:11](=[O:21])[CH2:12][N:13]3[CH2:20][CH2:19][CH2:18][C@H:14]3[C:15]([N:29]([CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[C:30](=[O:40])[C@H:31]([CH2:33][C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)[NH2:32])=[O:17])[CH2:2][CH:3]3[CH2:9][CH:7]([CH2:6][CH:5]([CH2:4]3)[CH2:10]1)[CH2:8]2
Reactant: N[C@@H](Cc1ccccc1)C(=O)NCc1ccccc1
Reactant: O=C(O)[C@@H]1CCCN1CC(=O)C12CC3CC(CC(C3)C1)C2
Solvent: CCN(CC)CC
Solvent: ClCCl
Product: N[C@@H](Cc1ccccc1)C(=O)N(Cc1ccccc1)C(=O)[C@@H]1CCCN1CC(=O)C12CC3CC(CC(C3)C1)C2
Temperature: 22 °C
Yield: 80.3 %

Procedure:
Using the procedure described previously, a solution of 1-(2-adamantan-1-yl-2-oxoethyl) L-proline (100 mg, 0.34 mmol, 1.0 eq), L-phenylalanine N-benzylamide (175 mg, 686 umol, 2.0 eq) and dichloromethane (1.0 mL), was cooled to 0° C., and treated with triethylamine (286 uL, 2.0 mmol, 6.0 eq). To this chilled solution was added a 50% solution of 1-n-propylphosphonic acid cyclic anhydride in dichloromethane (436 uL, 0.68 mL, 2.0 eq). When TLC indicated the reaction was complete, the solution was allowed to warm to 22° C., washed with satd aq NaHCO3, concentrated in vacuo, and purified by flash chromatography to provide 144 mg (80%) of L-phenylalanine, N-[1-(2-adamantan-1-yl-2-oxoethyl)-L-prolyl] benzylamide.
Reaction SMILES: Cl[C:2]1[N:7]=[N:6][C:5]([C:8]([NH:10][CH2:11][CH2:12][CH:13]([CH3:15])[CH3:14])=[O:9])=[CH:4][CH:3]=1.[CH3:16][O:17][C:18]1[CH:30]=[CH:29][CH:28]=[CH:27][C:19]=1[CH2:20][CH:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[CH3:16][O:17][C:18]1[CH:30]=[CH:29][CH:28]=[CH:27][C:19]=1[CH2:20][CH:21]1[CH2:26][CH2:25][N:24]([C:2]2[N:7]=[N:6][C:5]([C:8]([NH:10][CH2:11][CH2:12][CH:13]([CH3:15])[CH3:14])=[O:9])=[CH:4][CH:3]=2)[CH2:23][CH2:22]1
Reactant: CC(C)CCNC(=O)c1ccc(Cl)nn1
Reactant: COc1ccccc1CC1CCNCC1
Product: COc1ccccc1CC1CCN(c2ccc(C(=O)NCCC(C)C)nn2)CC1

Procedure:
The title compound was prepared in the same manner as described for Example 16 from 6-chloro-N-(3-methylbutyl)pyridazine-3-carboxamide and 4-(2-methoxybenzyl)piperidine. MS (+ESI) m/z 397 (MH+).
Reaction SMILES: [C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[S:15][CH:14]=[C:13]([C:16](=[N:18][NH:19][C:20]([C:22]3[CH:31]=[CH:30][C:25]([C:26]([O:28]C)=[O:27])=[CH:24][CH:23]=3)=[O:21])[CH3:17])[C:12]=2[OH:32])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+].Cl>CO>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[S:15][CH:14]=[C:13]([C:16](=[N:18][NH:19][C:20]([C:22]3[CH:23]=[CH:24][C:25]([C:26]([OH:28])=[O:27])=[CH:30][CH:31]=3)=[O:21])[CH3:17])[C:12]=2[OH:32])=[CH:7][CH:6]=1)([CH3:2])([CH3:3])[CH3:4]
Reactant: COC(=O)c1ccc(C(=O)NN=C(C)c2csc(-c3ccc(C(C)(C)C)cc3)c2O)cc1
Agent: Cl
Agent: [Na+]
Agent: [OH-]
Solvent: CO
Product: CC(=NNC(=O)c1ccc(C(=O)O)cc1)c1csc(-c2ccc(C(C)(C)C)cc2)c1O
Temperature: 25 °C
Yield: 22.9 %

Procedure:
Methyl 4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate (50 mg, 0.11 mmol) synthesized in Synthetic Example 35 was dissolved in methanol (1.1 mL) and stirred with 1 M aqueous sodium hydroxide (0.55 mL, 0.55 mmol) at 45° C. for 1.5 hours. After the stirring, 1 M hydrochloric acid (0.55 mL, 0.55 mmol) was added, and the precipitated pale yellow solid was recovered by filtration. The resulting solid was purified by silica gel chromatography (chloroform:methanol=9:1). The resulting solid was stirred with chloroform at room temperature and recovered by filtration to give the desired product as a pale yellow solid (11 mg, yield 23%).
Reaction SMILES: [C:1]([C:5]1[CH:18]=[CH:17][C:16]2[S:15][C:14]3[C:9](=[CH:10][C:11]([C:19]([CH3:22])([CH3:21])[CH3:20])=[CH:12][CH:13]=3)[CH2:8][C:7]=2[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].C([Li])CCC.[CH2:28]=[O:29].OS(O)(=O)=O>C1COCC1>[C:1]([C:5]1[CH:18]=[CH:17][C:16]2[S:15][C:14]3[C:9](=[CH:10][C:11]([C:19]([CH3:22])([CH3:21])[CH3:20])=[CH:12][CH:13]=3)[CH:8]([CH2:28][OH:29])[C:7]=2[CH:6]=1)([CH3:4])([CH3:3])[CH3:2]
Reactant: CC(C)(C)c1ccc2c(c1)Cc1cc(C(C)(C)C)ccc1S2
Reactant: C=O
Agent: O=S(=O)(O)O
Agent: [Li]CCCC
Solvent: C1CCOC1
Product: CC(C)(C)c1ccc2c(c1)C(CO)c1cc(C(C)(C)C)ccc1S2
Temperature: 25 °C
Reaction time: 0.5 h

Procedure:
To a solution of 15 g of 2,7-di-t-butylthioxanthene in 150 mL of dry THF cooled to -75°, mL of n-butyl lithium solution (2.45 M) was added dropwise. A deep red color developed. After stirring at -75° for 30 min., 5 g of paraformaldehyde was added slowly. The mixture was then allowed to warm to room temperature and refluxed for 30 min. Completion of the reaction was signaled by discharge of the red color. The mixture, which contained a gray precipitate, was cooled and decomposed with ice and 25% H2SO4. Extraction of the aqueous layer with CH2Cl2, followed by washing of the extracts with H2O and saturated NaCl solution, drying over (MgSO4) and then evaporation gave an oily material which was purified by chromatography on silica gel by elution with hexane-ethyl acetate (95/5). The alcohol was obtained as a white solid, m.p. 158°-159°. Anal. calculated for C22H28OS: C, 77.64; H, 8.13; S, 9.41. Found: C, 77.72; H, 8.52; S, 9.28.
Reaction SMILES: [OH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:11])[CH:6]=[C:5]2[CH:12]=[O:13].Br[CH2:15][C:16]([NH2:18])=[O:17].C(N=P(N(C)C)(N(C)C)N(C)C)(C)(C)C.Cl>O.CN(C=O)C>[CH:12]([C:5]1[C:4]2[C:8](=[CH:9][CH:10]=[C:2]([O:1][CH2:15][C:16]([NH2:18])=[O:17])[CH:3]=2)[N:7]([CH3:11])[CH:6]=1)=[O:13]
Reactant: Cn1cc(C=O)c2cc(O)ccc21
Reactant: NC(=O)CBr
Agent: CN(C)P(=NC(C)(C)C)(N(C)C)N(C)C
Agent: Cl
Solvent: CN(C)C=O
Solvent: O
Product: Cn1cc(C=O)c2cc(OCC(N)=O)ccc21
Temperature: 120 °C
Reaction time: 3.5 h

Procedure:
5-Hydroxy-1-methyl-1H-indole-3-carbaldehyde (I-2) (0.5 g, 2.86 mmol), 2-Bromo-acetamide (0.43 g, 3.1 mmol), and N′″-tert-butyl-N,N,N′,N′,N″,N″-hexamethyl-phosphorimidic triamide (2.18 mL, 8.6 mmol) were dissolved into anh. DMF (3 mL) in a seal tube. The resulting solution was then sealed and heated at 120° C. (monitored by LCMS). The reaction completed after 3.5 h. The mixture was cooled to room temperature, added 20 mL of water, and 6 N HCl to pH 2-3. The mixture was then extracted with ethyl acetate (20 mL×6). The organic layers were combined, washed with brine (10 mL×2), dried over Mg2SO4, filtered and dried under reduced pressure to give the title compound as 0.5 g orange powder (crude yield: 76%, used without further purification). LCMS (2-85% ACN/H2O in 7 min): M+ 233.1 (100%); 95% purity (at 220 nM).
Reaction SMILES: [Br:1][C:2]1[CH:3]=[C:4]([F:10])[C:5]([F:9])=[C:6]([OH:8])[CH:7]=1.Br[CH2:12][CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C.CCOC(C)=O>[Br:1][C:2]1[CH:3]=[C:4]([F:10])[C:5]([F:9])=[C:6]([CH:7]=1)[O:8][CH2:12][CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16]
Reactant: CCOC(=O)CCCBr
Reactant: Oc1cc(Br)cc(F)c1F
Agent: O=C([O-])[O-]
Agent: [K+]
Solvent: CN(C)C=O
Solvent: CCOC(C)=O
Product: CCOC(=O)CCCOc1cc(Br)cc(F)c1F
Temperature: 80 °C
Yield: 91 %

Procedure:
To a solution of 5-bromo-2,3-difluorophenol (Avocado, 2.5 g, 12.0 mmol) in DMF (50 mL) was added ethyl 4-bromobutyrate (2.57 g, 13.2 mmol) and K2CO3 (2.5 g, 18 mmol). The reaction mixture was heated at 80° C. for 3 hours. The reaction mixture was diluted with EtOAc and washed with water (3×) and brine, dried (MgSO4) and concentrated under vacuum affording the title compound as a colorless oil (3.53 g, 91%). 1H NMR (DMSO-d6, 300 MHz) δ 7.36 (m, 1H), 7.28 (m, 1H), 4.16-4.03 (m, 4H), 2.45 (t, 2H), 2.03-1.94 (m, 2H), 1.18 (t, 3H). LC/MS (Method B): 323.1, 325.0 (M+H)+. HPLC (Method A) Rt 4.94 min (Purity: 99.8%).
Reaction SMILES: [CH:1]1([O:4][C:5]2[CH:6]=[C:7]([C:11]3[CH:16]=[CH:15][C:14]([C:17](OC)=[O:18])=[CH:13][C:12]=3[CH:21]3[CH2:25][CH2:24][CH2:23][C:22]3([CH3:27])[CH3:26])[CH:8]=[CH:9][CH:10]=2)[CH2:3][CH2:2]1.[H-].[H-].[H-].[H-].[Li+].[Al+3].[OH-].[Na+]>C1COCC1>[CH:1]1([O:4][C:5]2[CH:6]=[C:7]([C:11]3[CH:16]=[CH:15][C:14]([CH2:17][OH:18])=[CH:13][C:12]=3[CH:21]3[CH2:25][CH2:24][CH2:23][C:22]3([CH3:27])[CH3:26])[CH:8]=[CH:9][CH:10]=2)[CH2:3][CH2:2]1
Reactant: COC(=O)c1ccc(-c2cccc(OC3CC3)c2)c(C2CCCC2(C)C)c1
Agent: [Al+3]
Agent: [H-]
Agent: [Li+]
Solvent: C1CCOC1
Product: CC1(C)CCCC1c1cc(CO)ccc1-c1cccc(OC2CC2)c1
Temperature: 0 °C
Reaction time: 0.75 h
Yield: 83.5 %

Procedure:
To a cooled solution of 66.48C (0.4115 g, 1.129 mmol) in dry THF (10 mL) at 0° C. was added LAH (1.0M in THF) (2.30 mL, 2.3 mmol) dropwise. Upon complete addition, the reaction was maintained at 0° C. and was monitored by TLC and LCMS. After 45 minutes, 1N NaOH was added to quench the reaction. The resulting mixture was extracted three times with EtOAc. After drying over anhydrous magnesium sulfate, filtration, and concentration, the residue was purified by flash chromatography (SiO2 gel 60, eluted with 0%-50% EtOAc in hexanes). Fractions containing the desired product were combined and concentrated to a colorless oil as 66.48D (317.1 mg, 83% yield). MS ESI (pos.) m/e: 319.0 (M−H2O)+. Chiral separation of 66.48D was accomplished on Chiracel-OD (3% IPA in hexane) to provide 66.48E (peak 1) and 66.48F (peak 2). Both enantiomers were used to synthesize example compounds, and both enantiomers gave active compounds.
Reaction SMILES: C(P(CCCC)CCCC)CCC.[CH3:14][O:15][C:16](=[O:30])[CH2:17][C:18]1[C:22]2[C:23]([Cl:28])=[CH:24][C:25]([OH:27])=[CH:26][C:21]=2[S:20][C:19]=1[CH3:29].[CH3:31][N:32]1[C:36]([CH2:37]O)=[CH:35][C:34]([C:39]([F:42])([F:41])[F:40])=[N:33]1.C1CCN(C(N=NC(N2CCCCC2)=O)=O)CC1>C1COCC1>[CH3:14][O:15][C:16](=[O:30])[CH2:17][C:18]1[C:22]2[C:23]([Cl:28])=[CH:24][C:25]([O:27][CH2:37][C:36]3[N:32]([CH3:31])[N:33]=[C:34]([C:39]([F:42])([F:40])[F:41])[CH:35]=3)=[CH:26][C:21]=2[S:20][C:19]=1[CH3:29]
Reactant: Cn1nc(C(F)(F)F)cc1CO
Reactant: COC(=O)Cc1c(C)sc2cc(O)cc(Cl)c12
Agent: CCCCP(CCCC)CCCC
Agent: O=C(N=NC(=O)N1CCCCC1)N1CCCCC1
Solvent: C1CCOC1
Product: COC(=O)Cc1c(C)sc2cc(OCc3cc(C(F)(F)F)nn3C)cc(Cl)c12
Temperature: 25 °C
Reaction time: 1 h
Yield: 90.9 %

Procedure:
To a mixture of tri-n-butylphosphine (0.415 mL), methyl(4-chloro-6-hydroxy-2-methyl-1-benzothiophen-3-yl)acetate (150 mg) and (1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanol (105 mg) in THF (4.0 mL) was added ADDP (419 mg) at room temperature. The mixture was stirred at room temperature under nitrogen atmosphere for 1 h. The mixture was concentrated. To the residue was added IPE and the precipitate was filtered off and the filtrate was concentrated in vacuo. The residue was purified by silica gel column chromatography (NH, EtOAc/hexane) and silica gel column chromatography (EtOAc/hexane) to give the title compound (218 mg) as a colorless solid. The solid was crystallized from EtOAc-hexane.
Reaction SMILES: [Cl:1][C:2]1[C:7]([CH2:8]O)=[CH:6][C:5]([N:10]2[C:14](=[O:15])[C:13]3[CH2:16][CH2:17][CH2:18][CH2:19][C:12]=3[C:11]2=[O:20])=[C:4]([F:21])[CH:3]=1.C(Br)(Br)(Br)[Br:23].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>C(OCC)C>[Cl:1][C:2]1[C:7]([CH2:8][Br:23])=[CH:6][C:5]([N:10]2[C:14](=[O:15])[C:13]3[CH2:16][CH2:17][CH2:18][CH2:19][C:12]=3[C:11]2=[O:20])=[C:4]([F:21])[CH:3]=1
Reactant: BrC(Br)(Br)Br
Reactant: O=C1C2=C(CCCC2)C(=O)N1c1cc(CO)c(Cl)cc1F
Agent: c1ccc(P(c2ccccc2)c2ccccc2)cc1
Solvent: CCOCC
Product: O=C1C2=C(CCCC2)C(=O)N1c1cc(CBr)c(Cl)cc1F
Reaction time: 8 h

Procedure:
To a stirred solution of 3.0 g (0.0097 mole) of of N-(4-chloro-2-fluoro-5-hydroxymethylphenyl)-3,4,5,6-tetrahydrophthalimide, prepared by the method of Example 4, and 6.4 g (0.0194 mole) of carbon tetrabromide in 30 ml of diethyl ether was added portionwise 5.1 g (0.0194 mole) of triphenylphosphine. This mixture was stirred overnight and was then filtered to remove the solid which had formed, and the solvent was evaporated under reduced pressure. The residue was passed through a column of silica gel. Appropriate fractions were combined, and the solvent was evaporated yielding 1.1 g of N-(4-chloro-2-fluoro-5-bromomethylphenyl)-3,4,5,6tetrahydrophthalimide as a white solid, m .p. 126°-128° C. The nmr and ir spectra were consistent with the proposed structure.
Reaction SMILES: [O:1]=[C:2]1[NH:7][C:6]2[CH:8]=[C:9]([C:12](OC)=[O:13])[CH:10]=[N:11][C:5]=2[N:4]2[CH2:16][CH2:17][CH2:18][CH2:19][CH:3]12.[H-].[Na+].[H-].[Al+3].[Li+].[H-].[H-].[H-].CO>O1CCCC1.O.C(OCC)(=O)C>[OH:13][CH2:12][C:9]1[CH:10]=[N:11][C:5]2[N:4]3[CH2:16][CH2:17][CH2:18][CH2:19][CH:3]3[C:2](=[O:1])[NH:7][C:6]=2[CH:8]=1
Reactant: COC(=O)c1cnc2c(c1)NC(=O)C1CCCCN21
Agent: [Al+3]
Agent: [H-]
Agent: [Li+]
Solvent: CO
Solvent: CCOC(C)=O
Solvent: C1CCOC1
Product: O=C1Nc2cc(CO)cnc2N2CCCCC12
Temperature: -45 °C
Reaction time: 0.5 h
Yield: 96.4 %

Procedure:
Methyl 6-oxo-6,6a,7,8,9,10-hexahydro-5H-dipyrido[1,2-a:3′,2′-e]pyrazine-3-carboxylate (500 mg, 1.91 mmol) was taken up in tetrahydrofuran (23 mL) in an inert environment. To the stirred suspension at room temperature was added NaH (60% dispersion in mineral oil, 114.7 mg, 2.87 mmol) and stirred 30 min. The reaction was then cooled to −45° C. and lithium aluminum hydride (2M in THF, 1.91 mL, 3.82 mmol) was added. The reaction was stirred at a temperature between −20 and −10° C. for 1 h. The reaction was then cooled back to −60° C. and MeOH (1 mL) followed by water (1 mL) was added. The reaction was allowed to stir at ambient temperature for 2 h and then poured into ethyl acetate (300 mL) and water (200 mL). The biphasic mixture was stirred vigorously and then filtered through a medium frit. The layers were separated and the aqueous phase was extracted with ethyl acetate (3×100 mL). The organic layers were combined, washed with brine (100 mL), dried with sodium sulfate and concentrated to yield the title compound (429.4 mg, 96%) as a white solid. [M+H] calc'd for C12H15N3O2, 234. found, 234.
Reaction SMILES: [NH2:1][C:2]1[CH:10]=[C:9]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:8]([O:19][CH3:20])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[CH3:21]N(C=NC=[N+](C)C)C.[Cl-].C([O-])(=O)C.[Na+].C(O)(=O)C>O1CCOCC1>[CH2:12]([O:11][C:9]1[CH:10]=[C:2]2[C:3]([C:4](=[O:5])[NH:6][CH:21]=[N:1]2)=[CH:7][C:8]=1[O:19][CH3:20])[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1
Reactant: CN(C)C=NC=[N+](C)C
Reactant: COc1cc(C(N)=O)c(N)cc1OCc1ccccc1
Agent: CC(=O)[O-]
Agent: [Cl-]
Agent: [Na+]
Solvent: CC(=O)O
Solvent: C1COCCO1
Product: COc1cc2c(=O)[nH]cnc2cc1OCc1ccccc1
Yield: 77 %

Procedure:
A mixture of 2-amino-4-benzyloxy-5-methoxybenzamide (10 g, 0.04 mol), (J. Med. Chem. 1977, vol 20, 146-149), and Gold's reagent (7.4 g, 0.05 mol) in dioxane (100 ml) was stirred and heated at reflux for 24 hours. Sodium acetate (3.02 g, 0.037 mol) and acetic acid (11.65 ml, 0.029 mol) were added to the reaction mixture and it was heated for a further 3 hours. The mixture was evaporated, water was added to the residue, the solid was filtered off, washed with water and dried (MgSO4). Recrystallisation from acetic acid gave 7-benzyloxy-6-methoxy-3,4-dihydroquinazolin-4-one (8.7 g, 84%).