ITEM 1. FINANCIAL STATEMENTS
CARDIFF ONCOLOGY, INC.
CONDENSED BALANCE SHEETS
(in thousands, except par value)
(Unaudited)
| June 30,2022 | December 31,2021 |
| Assets |
| Current assets: |
| Cash and cash equivalents | $ | 20,965 | $ | 11,943 |
| Short-term investments | 101,041 | 128,878 |
| Accounts receivable and unbilled receivable | 551 | 535 |
| Prepaid expenses and other current assets | 4,857 | 4,771 |
| Total current assets | 127,414 | 146,127 |
| Property and equipment, net | 1,138 | 382 |
| Operating lease right-of-use assets | 2,524 | 2,796 |
| Other assets | 185 | 239 |
| Total Assets | $ | 131,261 | $ | 149,544 |
| Liabilities and Stockholders’ Equity |
| Current liabilities: |
| Accounts payable | $ | 1,522 | $ | 1,439 |
| Accrued liabilities | 6,279 | 4,527 |
| Operating lease liabilities | 670 | 551 |
| Other current liabilities | 10 | 42 |
| Total current liabilities | 8,481 | 6,559 |
| Operating lease liabilities, net of current portion | 2,306 | 2,568 |
| Total Liabilities | 10,787 | 9,127 |
| Commitments and contingencies (Note 7) |
| Stockholders’ equity |
| Preferred stock, 20,000 shares authorized; (Note 6) | — | 1 |
| Common stock, $ 0.0001 par value, 150,000 shares authorized; 43,306 and 41,964 shares issued and outstanding at June 30, 2022 and December 31, 2021, respectively | 4 | 4 |
| Additional paid-in capital | 402,710 | 400,503 |
| Service receivables | — | ( 139 ) |
| Accumulated other comprehensive loss | ( 982 ) | ( 142 ) |
| Accumulated deficit | ( 281,258 ) | ( 259,810 ) |
| Total stockholders’ equity | 120,474 | 140,417 |
| Total liabilities and stockholders’ equity | $ | 131,261 | $ | 149,544 |

See accompanying notes to the unaudited condensed financial statements.
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CARDIFF ONCOLOGY, INC.
CONDENSED STATEMENTS OF OPERATIONS
(in thousands, except per share amounts)
(Unaudited)
| Three Months Ended June 30, | Six Months Ended June 30, |
| 2022 | 2021 | 2022 | 2021 |
| Royalty revenues | $ | 91 | $ | 68 | $ | 165 | $ | 140 |
| Costs and expenses: |
| Research and development | 7,448 | 4,119 | 14,656 | 7,398 |
| Selling, general and administrative | 3,086 | 2,838 | 7,026 | 5,073 |
| Total operating expenses | 10,534 | 6,957 | 21,682 | 12,471 |
| Loss from operations | ( 10,443 ) | ( 6,889 ) | ( 21,517 ) | ( 12,331 ) |
| Other income (expense), net: |
| Interest income, net | 253 | 71 | 383 | 115 |
| Gain (loss) from change in fair value of derivative financial instruments—warrants | — | 61 | — | 268 |
| Other income (expense), net | ( 253 ) | — | ( 302 ) | 12 |
| Total other income (expense), net | — | 132 | 81 | 395 |
| Net loss | ( 10,443 ) | ( 6,757 ) | ( 21,436 ) | ( 11,936 ) |
| Preferred stock dividend payable on Series A Convertible Preferred Stock | ( 6 ) | ( 6 ) | ( 12 ) | ( 12 ) |
| Net loss attributable to common stockholders | $ | ( 10,449 ) | $ | ( 6,763 ) | $ | ( 21,448 ) | $ | ( 11,948 ) |
| Net loss per common share — basic and diluted | $ | ( 0.24 ) | $ | ( 0.17 ) | $ | ( 0.50 ) | $ | ( 0.31 ) |
| Weighted-average shares outstanding — basic and diluted | 43,306 | 38,761 | 43,269 | 37,967 |

See accompanying notes to the unaudited condensed financial statements.
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CARDIFF ONCOLOGY, INC.
CONDENSED STATEMENTS OF COMPREHENSIVE LOSS
(in thousands)
(Unaudited)
| Three Months Ended June 30, | Six Months Ended June 30, |
| 2022 | 2021 | 2022 | 2021 |
| Net loss | $ | ( 10,443 ) | $ | ( 6,757 ) | $ | ( 21,436 ) | $ | ( 11,936 ) |
| Other comprehensive loss: |
| Unrealized gain (loss) on securities available-for-sale | ( 234 ) | 57 | ( 840 ) | ( 10 ) |
| Total comprehensive loss | ( 10,677 ) | ( 6,700 ) | ( 22,276 ) | ( 11,946 ) |
| Preferred stock dividend payable on Series A Convertible Preferred Stock | ( 6 ) | ( 6 ) | ( 12 ) | ( 12 ) |
| Comprehensive loss attributable to common stockholders | $ | ( 10,683 ) | $ | ( 6,706 ) | $ | ( 22,288 ) | $ | ( 11,958 ) |

See accompanying notes to the unaudited condensed financial statements.
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CARDIFF ONCOLOGY, INC.
CONDENSED STATEMENTS OF STOCKHOLDERS’ EQUITY
(in thousands)
(Unaudited)
| Preferred StockShares | Preferred StockAmount | Common StockShares | Common StockAmount | Additional Paid-In Capital | Service Receivable | Accumulated Other Comprehensive Loss | Accumulated Deficit | TotalStockholders’ Equity |
| Balance, January 1, 2022 | 716 | $ | 1 | 41,964 | $ | 4 | $ | 400,503 | $ | ( 139 ) | $ | ( 142 ) | $ | ( 259,810 ) | $ | 140,417 |
| Stock-based compensation | — | — | — | — | 1,152 | — | — | — | 1,152 |
| Other comprehensive loss | — | — | — | — | — | — | ( 606 ) | — | ( 606 ) |
| Issuance of common stock upon conversion of Series E Convertible Preferred Stock | ( 328 ) | ( 1 ) | 1,342 | — | — | — | — | — | ( 1 ) |
| Preferred stock dividend | — | — | — | — | — | — | — | ( 6 ) | ( 6 ) |
| Release of clinical trial funding commitment | — | — | — | — | — | 139 | — | — | 139 |
| Net loss | — | — | — | — | — | — | — | ( 10,993 ) | ( 10,993 ) |
| Balance, March 31, 2022 | 388 | — | 43,306 | 4 | 401,655 | — | ( 748 ) | ( 270,809 ) | 130,102 |
| Stock-based compensation | — | — | — | — | 1,055 | — | — | — | 1,055 |
| Other comprehensive loss | — | — | — | — | — | — | ( 234 ) | — | ( 234 ) |
| Preferred stock dividend | — | — | — | — | — | — | — | ( 6 ) | ( 6 ) |
| Net loss | — | — | — | — | — | — | — | ( 10,443 ) | ( 10,443 ) |
| Balance, June 30, 2022 | 388 | $ | — | 43,306 | $ | 4 | $ | 402,710 | $ | — | $ | ( 982 ) | $ | ( 281,258 ) | $ | 120,474 |

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CARDIFF ONCOLOGY, INC.
CONDENSED STATEMENTS OF STOCKHOLDERS’ EQUITY
(in thousands)
(Unaudited)
| Preferred StockShares | Preferred StockAmount | Common StockShares | Common StockAmount | Additional Paid-In Capital | Service Receivable | Accumulated Other Comprehensive Loss | Accumulated Deficit | TotalStockholders’ Equity |
| Balance, January 1, 2021 | 716 | $ | 1 | 36,781 | $ | 4 | $ | 361,819 | $ | ( 2,171 ) | $ | — | $ | ( 231,495 ) | $ | 128,158 |
| Stock-based compensation | — | — | — | — | 268 | — | — | — | 268 |
| Issuance of common stock upon exercise of warrants | — | — | 771 | — | 1,263 | — | — | — | 1,263 |
| Other comprehensive loss | — | — | — | — | — | — | ( 67 ) | — | ( 67 ) |
| Preferred stock dividend | — | — | — | — | — | — | — | ( 6 ) | ( 6 ) |
| Release of clinical trial funding commitment | — | — | — | — | — | 380 | — | — | 380 |
| Net loss | — | — | — | — | — | — | — | ( 5,179 ) | ( 5,179 ) |
| Balance, March 31, 2021 | 716 | 1 | 37,552 | 4 | 363,350 | ( 1,791 ) | ( 67 ) | ( 236,680 ) | 124,817 |
| Stock-based compensation | — | — | — | — | 1,036 | — | — | — | 1,036 |
| Sale of common stock, net of expenses(1) | — | — | 2,000 | — | 19,225 | — | — | — | 19,225 |
| Other comprehensive gain | — | — | — | — | — | — | 57 | — | 57 |
| Preferred stock dividend | — | — | — | — | — | — | — | ( 6 ) | ( 6 ) |
| Release of clinical trial funding commitment | — | — | — | — | — | 546 | — | — | 546 |
| Net loss | — | — | — | — | — | — | — | ( 6,757 ) | ( 6,757 ) |
| Balance, June 30, 2021 | 716 | $ | 1 | 39,552 | $ | 4 | $ | 383,611 | $ | ( 1,245 ) | $ | ( 10 ) | $ | ( 243,443 ) | $ | 138,918 |

(1) Net of expenses of $ 0.8 million.
See accompanying notes to the unaudited condensed financial statements.
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CARDIFF ONCOLOGY, INC.
CONDENSED STATEMENTS OF CASH FLOWS
(in thousands)
(Unaudited)
| Six Months Ended June 30, |
| 2022 | 2021 |
| Operating activities |
| Net loss | $ | ( 21,436 ) | $ | ( 11,936 ) |
| Adjustments to reconcile net loss to net cash used in operating activities: |
| Loss on disposal of assets | — | 1 |
| Depreciation | 69 | 228 |
| Stock-based compensation expense | 2,207 | 1,304 |
| Amortization of premiums on short-term investments | 557 | 698 |
| Change in fair value of derivative financial instruments—warrants | — | ( 268 ) |
| Release of clinical trial funding commitment | 139 | 926 |
| Changes in operating assets and liabilities: |
| Other assets | 54 | 141 |
| Accounts receivable and unbilled receivable | ( 16 ) | 12 |
| Prepaid expenses and other assets | 18 | 68 |
| Operating lease right-of-use assets | 272 | 165 |
| Accounts payable and accrued expenses | 1,367 | ( 1,121 ) |
| Operating lease liabilities | ( 143 ) | ( 461 ) |
| Other liabilities | ( 32 ) | 58 |
| Net cash used in operating activities | ( 16,944 ) | ( 10,185 ) |
| Investing activities: |
| Capital expenditures | ( 483 ) | — |
| Insurance proceeds from casualty loss | 71 | — |
| Maturities of short-term investments | 48,801 | 5,510 |
| Purchases of short-term investments | ( 57,309 ) | ( 141,948 ) |
| Sales of short-term investments | 34,886 | 5,735 |
| Net cash provided by (used in) investing activities | 25,966 | ( 130,703 ) |
| Financing activities: |
| Proceeds from sales of common stock, net of expenses of $0 and $ 776 , respectively | — | 19,225 |
| Proceeds from exercise of warrants | — | 1,263 |
| Net cash provided by financing activities | — | 20,488 |
| Net change in cash and cash equivalents | 9,022 | ( 120,400 ) |
| Cash and cash equivalents—Beginning of period | 11,943 | 130,981 |
| Cash and cash equivalents—End of period | $ | 20,965 | $ | 10,581 |
| Supplementary disclosure of cash flow activity: |
| Cash paid for taxes | $ | 1 | $ | 1 |
| Supplemental disclosure of non-cash investing and financing activities: |
| Acquisition of property and equipment included in accounts payable and accrued expenses | $ | 456 | $ | 27 |
| Acquisition of property and equipment included in insurance proceeds receivable | $ | 43 | $ | — |
| Preferred stock dividend payable on Series A Convertible Preferred Stock | $ | 12 | $ | 12 |

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See accompanying notes to the unaudited condensed financial statements.
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CARDIFF ONCOLOGY, INC.
NOTES TO CONDENSED FINANCIAL STATEMENTS
(Unaudited)
1. Organization and Basis of Presentation
Business Organization and Overview
Cardiff Oncology, Inc. (“Cardiff Oncology” or the “Company”) headquartered in San Diego, California, is a clinical-stage biotechnology company leveraging Polo-like Kinase 1 (“PLK1”) inhibition to develop novel therapies across a range of cancers with the greatest unmet medical need, including KRAS-mutated metastatic colorectal cancer, metastatic pancreatic cancer and metastatic castration-resistant prostate cancer. The Company's common stock is listed on the Nasdaq Capital Market under the ticker symbol "CRDF".
Basis of Presentation
The accompanying unaudited interim condensed financial statements of Cardiff Oncology have been prepared in accordance with accounting principles generally accepted in the United States of America (“GAAP”) and the rules and regulations of the Securities and Exchange Commission (“SEC”) related to a quarterly report on Form 10-Q. Certain information and note disclosures normally included in annual financial statements prepared in accordance with GAAP have been condensed or omitted pursuant to those rules and regulations. The unaudited interim condensed financial statements reflect all adjustments consisting of normal recurring adjustments which, in the opinion of management, are necessary for a fair statement of the Company’s financial position and the results of its operations and cash flows for the periods presented. The unaudited condensed balance sheet at December 31, 2021, has been derived from the audited financial statements at that date but does not include all of the information and disclosures required by GAAP for annual financial statements. The operating results presented in these unaudited interim condensed financial statements are not necessarily indicative of the results that may be expected for any future periods. These unaudited interim condensed financial statements should be read in conjunction with the audited financial statements and the notes thereto for the year ended December 31, 2021, included in the Company’s annual report on Form 10-K filed with the SEC on February 24, 2022.
Liquidity
The Company has incurred net losses since its inception and has negative operating cash flows. As of June 30, 2022, the Company had $ 122.0 million in cash, cash equivalents and short-term investments and believes it has sufficient cash to meet its funding requirements for at least the next 12 months following the issuance date of these financial statements.
For the foreseeable future, the Company expects to continue to incur losses and require additional capital to further advance its clinical trial programs and support its other operations. The Company cannot be certain that additional funding will be available on acceptable terms, or at all. To the extent that the Company can raise additional funds by issuing equity securities, the Company’s stockholders may experience additional dilution.
2. Summary of Significant Accounting Policies
During the six months ended June 30, 2022, there have been no changes to the Company’s significant accounting policies as described in its Annual Report on Form 10-K for the fiscal year ended December 31, 2021.
Net Loss Per Share
Basic and diluted net loss per common share is determined by dividing net loss applicable to common stockholders by the weighted-average common shares outstanding during the period. Preferred dividends are included in net loss attributable to common stockholders in the computation of basic and diluted earnings per share.
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The following table sets forth the outstanding potentially dilutive securities that have been excluded in the calculation of diluted net loss per share because their effect was anti-dilutive:
| June 30, |
| 2022 | 2021 |
| Options to purchase Common Stock | 5,131,195 | 2,966,843 |
| Warrants to purchase Common Stock | 4,490,159 | 4,490,159 |
| Series A Convertible Preferred Stock | 877 | 877 |
| Series E Convertible Preferred Stock | 1,342,250 | 2,684,607 |
| 10,964,481 | 10,142,486 |

Recently Adopted Accounting Pronouncement
In May 2021, the FASB issued ASU No. 2021-04 ("ASU 2021-04"), Earnings Per Share (Topic 260), Debt—Modifications and Extinguishments (Subtopic 470-50), Compensation—Stock Compensation (Topic 718), and Derivatives and Hedging—Contracts in Entity’s Own Equity (Subtopic 815-40): Issuer’s Accounting for Certain Modifications or Exchanges of Freestanding Equity-Classified Written Call Options (a consensus of the FASB Emerging Issues Task Force). The amendments in this update are effective for all entities for fiscal years beginning after December 15, 2021, including interim periods within those fiscal years. The Company has prospectively adopted this standard as of January 1, 2022 for periods presented after the adoption. The adoption of ASU 2021-04 did not have a material impact on the Company's financial statements.
Recent Accounting Pronouncement Not Yet Adopted
In August 2020, the FASB issued ASU No. 2020-06 ("ASU 2020-06"), Debt - Debt with Conversion and Other Options (Subtopic 470-20) and Derivatives and Hedging - Contracts in Entity’s Own Equity (Subtopic 815-40) (“ASU 2020-06”). ASU 2020-06 eliminates the beneficial conversion and cash conversion accounting models for convertible instruments. It also amends the accounting for certain contracts in an entity’s own equity that are currently accounted for as derivatives because of specific settlement provisions. In addition, ASU 2020-06 modifies how particular convertible instruments and certain contracts that may be settled in cash or shares impact the diluted EPS computation. The amendments in this update are effective for public business entities for fiscal years beginning after December 15, 2021 (or December 15, 2023, for companies who meet the SEC definition of Smaller Reporting Companies), and interim periods within those fiscal years. The amendment is to be adopted through either a fully retrospective or modified retrospective method of transition. Early adoption is permitted. The Company is currently evaluating the impact of this standard on its financial statements and related disclosures.
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3. Fair Value Measurements
The following table presents the Company’s assets and liabilities that are measured and recognized at fair value on a recurring basis classified under the appropriate level of the fair value hierarchy as of June 30, 2022 and December 31, 2021:
| Fair Value Measurements atJune 30, 2022 |
| (in thousands) | Quoted Prices in Active Markets for Identical Assets and Liabilities(Level 1) | Significant Other Observable Inputs(Level 2) | Significant Unobservable Inputs(Level 3) | Total |
| Assets: |
| Money market fund | $ | 20,089 | $ | — | $ | — | $ | 20,089 |
| Total included in cash and cash equivalents | 20,089 | — | — | 20,089 |
| Available for sale investments: |
| Certificate of deposit | — | 12,860 | — | 12,860 |
| Corporate debt securities | — | 63,386 | — | 63,386 |
| Commercial paper | — | 10,135 | — | 10,135 |
| U.S. treasury securities | 14,660 | — | — | 14,660 |
| Total available for sale investments (1) | 14,660 | 86,381 | — | 101,041 |
| Total assets measured at fair value on a recurring basis | $ | 34,749 | $ | 86,381 | $ | — | $ | 121,130 |

| Fair Value Measurements atDecember 31, 2021 |
| (in thousands) | Quoted Prices in Active Markets for Identical Assets and Liabilities(Level 1) | Significant Other Observable Inputs(Level 2) | Significant Unobservable Inputs(Level 3) | Total |
| Assets: |
| Money market fund | $ | 10,990 | $ | — | $ | — | $ | 10,990 |
| Total included in cash and cash equivalents | 10,990 | $ | — | — | 10,990 |
| Available for sale investments: |
| Certificate of deposit | — | 1,260 | — | 1,260 |
| Corporate debt securities | — | 88,390 | — | 88,390 |
| Commercial paper | — | 14,454 | — | 14,454 |
| Non U.S. government | — | 728 | — | 728 |
| U.S. treasury securities | 24,046 | — | — | 24,046 |
| Total available for sale investments (1) | 24,046 | 104,832 | — | 128,878 |
| Total assets measured at fair value on a recurring basis | $ | 35,036 | $ | 104,832 | $ | — | $ | 139,868 |

(1) Included in short-term investments in the accompanying balance sheets.
The Company’s policy is to recognize transfers between levels of the fair value hierarchy on the date of the event or change in circumstances that caused the transfer. There were no transfers into or out of Level 3 during the six months ended June 30, 2022 .
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4. Supplementary Balance Sheet Information
Investments available for sale
Investments available for sale consist of the following:
| As of June 30,2022 |
| (in thousands) | Amortized Cost | Gross Unrealized Gains | Gross Unrealized Losses | Fair Market Value |
| Maturity less than 1 year: |
| Certificate of deposit | $ | 12,922 | $ | 1 | $ | ( 63 ) | $ | 12,860 |
| Corporate debt securities | 59,453 | — | ( 626 ) | 58,827 |
| Commercial paper | 10,228 | — | ( 93 ) | 10,135 |
| U.S. treasury securities | 13,034 | — | ( 133 ) | 12,901 |
| Total maturity less than 1 year | 95,637 | 1 | ( 915 ) | 94,723 |
| Maturity 1 to 2 years: |
| Corporate debt securities | 4,616 | — | ( 57 ) | 4,559 |
| U.S. treasury securities | 1,770 | — | ( 11 ) | 1,759 |
| Total maturity 1 to 2 years | 6,386 | — | ( 68 ) | 6,318 |
| Total short-term investments | $ | 102,023 | $ | 1 | $ | ( 983 ) | $ | 101,041 |

| As of December 31, 2021 |
| (in thousands) | Amortized Cost | Gross Unrealized Gains | Gross Unrealized Losses | Fair Market Value |
| Maturity less than 1 year: |
| Certificate of deposit | $ | 1,260 | $ | — | $ | — | $ | 1,260 |
| Corporate debt securities | 58,822 | 2 | ( 38 ) | 58,786 |
| Commercial paper | 14,453 | 4 | ( 3 ) | 14,454 |
| Non U.S. government | 728 | — | — | 728 |
| U.S. treasury securities | 20,380 | — | ( 24 ) | 20,356 |
| Total maturity less than 1 year | 95,643 | 6 | ( 65 ) | 95,584 |
| Maturity 1 to 2 years: |
| Corporate debt securities | 29,676 | 1 | ( 73 ) | 29,604 |
| U.S. treasury securities | 3,701 | — | ( 11 ) | 3,690 |
| Total maturity 1 to 2 years | 33,377 | 1 | ( 84 ) | 33,294 |
| Total short-term investments | $ | 129,020 | $ | 7 | $ | ( 149 ) | $ | 128,878 |

Unrealized losses in investments available for sale debt securities at June 30, 2022, were primarily due to increases in interest rates, not due to increased credit risks associated with specific securities. We do not intend to sell these investments and it is not more likely than not that we will be required to sell the investments before recovery of their amortized cost bases, which may be at maturity.
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Property and equipment
Property and equipment consist of the following:
| (in thousands) | As of June 30,2022 | As of December 31,2021 |
| Furniture and office equipment | $ | 1,212 | $ | 955 |
| Leasehold improvements | 2,445 | 1,962 |
| Laboratory equipment | 956 | 906 |
| 4,613 | 3,823 |
| Less—accumulated depreciation and amortization | ( 3,475 ) | ( 3,441 ) |
| Property and equipment, net | $ | 1,138 | $ | 382 |

Accrued Liabilities
Accrued liabilities consisted of the following:
| (in thousands) | As of June 30,2022 | As of December 31,2021 |
| Accrued compensation | $ | 1,304 | $ | 1,435 |
| Preferred stock dividend | 426 | 414 |
| Clinical trials | 1,780 | 1,639 |
| Research agreements and services | 1,697 | 726 |
| Director fees | 122 | 141 |
| Professional fees and outside services | 28 | 63 |
| Patent, license and other fees | 40 | 43 |
| Other accrued liabilities | 882 | 66 |
| Total accrued liabilities | $ | 6,279 | $ | 4,527 |

5. Leases
As a lessee, the Company’s current leases include its master facility lease and immaterial equipment leases, all of which are considered operating leases.
Master Facility Lease
The Company currently leases 12,300 square feet of office and lab space in San Diego that expires on February 28, 2027. The lease currently requires monthly payments of approximately $ 60,000 per month with 3 % annual escalation.
Facility Subleases
As a result of corporate restructurings in previous years, the Company vacated a portion of its facility and subleased the space to third parties under three separate sublease agreements, which all expired on December 31, 2021. Prior to the expiration of the sublease agreements, the Company as a sublessor was leasing approximately 16,600 square feet of space to third parties.
The components of lease expense were as follows:
| Three Months Ended June 30, | Six Months Ended June 30, |
| (in thousands) | 2022 | 2021 | 2022 | 2021 |
| Operating lease cost | $ | 190 | $ | 92 | $ | 381 | $ | 187 |
| Operating sublease income | — | ( 101 ) | — | ( 202 ) |
| Net operating lease cost | $ | 190 | $ | ( 9 ) | $ | 381 | $ | ( 15 ) |

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Supplemental balance sheet information related to leases was as follows:
| (in thousands) | As of June 30,2022 | As of December 31,2021 |
| Operating lease ROU assets | $ | 2,524 | $ | 2,796 |
| Current operating lease liabilities | $ | 670 | $ | 551 |
| Non-current operating lease liabilities | 2,306 | 2,568 |
| Total operating lease liabilities | $ | 2,976 | $ | 3,119 |
| Weighted-average remaining lease term–operating leases | 4.7 years | 5.2 years |
| Weighted-average discount rate–operating leases | 7.0 | % | 7.0 | % |

Supplemental cash flow and other information related to leases was as follows:
| Three Months Ended June 30, | Six Months Ended June 30, |
| (in thousands) | 2022 | 2021 | 2022 | 2021 |
| Cash paid for amounts included in the measurement of lease liabilities: |
| Operating cash flows from operating leases | $ | 180 | $ | 243 | $ | 251 | $ | 483 |

Total remaining annual commitments under non-cancelable lease agreements for each of the years ended December 31 are as follows:
| (in thousands) |
| Year Ending December 31, | Operating Leases |
| 2022 (excluding the six months ended June 30, 2022) | $ | 300 |
| 2023 | 737 |
| 2024 | 754 |
| 2025 | 775 |
| 2026 | 796 |
| Thereafter | 137 |
| Total future minimum lease payments | 3,499 |
| Less imputed interest | ( 523 ) |
| Total | $ | 2,976 |

6. Stockholders’ Equity
Stock Options
Stock-based compensation expense related to Cardiff Oncology equity awards have been recognized in operating results as follows:
| Three Months Ended June 30, | Six Months Ended June 30, |
| (in thousands) | 2022 | 2021 | 2022 | 2021 |
| Included in research and development expense | $ | 126 | $ | 72 | $ | 460 | $ | 112 |
| Included in selling, general and administrative expense | 929 | 964 | 1,747 | 1,192 |
| Total stock-based compensation expense | $ | 1,055 | $ | 1,036 | $ | 2,207 | $ | 1,304 |

The unrecognized compensation cost related to non-vested stock options outstanding at June 30, 2022, net of estimated forfeitures, was $ 10.8 million, which is expected to be recognized over a weighted-average remaining vesting period of 3.0 years. The weighted-average remaining contractual term of outstanding options as of June 30, 2022, was approximately 7.9
15
years. The total fair value of stock options vested during the six months ended June 30, 2022 and 2021, were $ 3.0 million and $ 1.2 million, respectively.
The estimated fair value of stock option awards was determined on the date of grant using the Black-Scholes option valuation model with the following weighted-average assumptions during the following periods indicated:
| Six Months Ended June 30, |
| 2022 | 2021 |
| Risk-free interest rate | 1.87 | % | 0.94 | % |
| Dividend yield | 0 | % | 0 | % |
| Expected volatility of Cardiff Oncology common stock | 106 | % | 108 | % |
| Expected term | 6.0 years | 6.0 years |

A summary of stock option activity and changes in stock options outstanding is presented below:
| Total Options | Weighted-AverageExercise PricePer Share | IntrinsicValue |
| Balance outstanding, December 31, 2021 | 3,771,984 | $ | 7.13 | $ | 6,405,258 |
| Granted | 1,731,136 | $ | 3.15 |
| Canceled / Forfeited | ( 371,125 ) | $ | 4.77 |
| Expired | ( 800 ) | $ | 165.84 |
| Balance outstanding, June 30, 2022 | 5,131,195 | $ | 5.93 | $ | 80,809 |
| Exercisable at June 30, 2022 | 2,030,219 | $ | 7.49 | $ | 34,443 |
| Vested and expected to vest at June 30, 2022 | 5,042,299 | $ | 5.95 | $ | 77,880 |

2021 Equity Incentive Plan
In June 2021 the Company's stockholders approved the 2021 Omnibus Equity Incentive Plan ("2021 Plan"). The number of authorized shares in the 2021 Plan is equal to the sum of (i) 3,150,000 shares, plus (ii) the number of shares of Common Stock reserved, but unissued under the 2014 Plan; and (iii) the number of shares of Common Stock underlying forfeited awards under the 2014 Plan. On June 9, 2022 the shareholders approved an increase of shares authorized in the 2021 Plan to 5,150,000 from 3,150,000 . As of June 30, 2022, there were 3,055,281 shares available for issuance under the 2021 Plan.
2014 Equity Incentive Plan
Subsequent to the adoption of the 2021 Plan, no additional equity awards can be made under the terms of the 2014 Plan.
Inducement Grants
In July 2021, the Company began issuing equity awards to certain new employees as inducement grants outside of its 2021 Plan. As of June 30, 2022, an aggregate of 920,208 shares were issuable upon the exercise of inducement grant stock options approved by the Company.
Modification of Stock Options
In June 2022 one of the Company's directors did not seek another term on the Board of Directors. At the time of departure, the Compensation Committee passed a resolution to extend the expiration date of the vested stock options, and to immediately accelerate the vesting of the unvested options. The Company recorded incremental reduction to stock compensation expense of $ 0.1 million during the three months ended June 30, 2022, related to the modifications.
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Warrants
A summary of warrant activity and changes in warrants outstanding, including both liability and equity classifications is presented below:
| Total Warrants | Weighted-AverageExercise PricePer Share | Weighted-AverageRemaining ContractualTerm |
| Balance outstanding, December 31, 2021 | 4,490,159 | $ | 5.80 | 3.0 years |
| Balance outstanding, June 30, 2022 | 4,490,159 | $ | 5.80 | 2.5 years |

Preferred Stock
A summary of our Company's classes of preferred stock is presented below:
| Shares outstanding |
| Class | Par value | Shares designated | Liquidation preference | As of June 30,2022 | As of December 31,2021 |
| Series A Convertible Preferred Stock | $ | 0.001 | 277,100 | $ | 606,000 | 60,600 | 60,600 |
| Series B Convertible Preferred Stock | $ | 0.001 | 8,860 | None | — | — |
| Series C Convertible Preferred Stock | $ | 0.001 | 200,000 | None | — | — |
| Series D Convertible Preferred Stock | $ | 0.0001 | 154,670 | None | — | — |
| Series E Convertible Preferred Stock | $ | 0.001 | 865,824 | None | 327,509 | 655,044 |

7. Commitments and Contingencies
Executive Agreements
Certain executive agreements provide for severance payments in case of terminations without cause or certain change of control scenarios.
Research and Development Agreements
In March 2017, the Company entered into a license agreement with Nerviano which granted the Company development and commercialization rights to NMS-1286937, which Cardiff Oncology refers to as onvansertib. Onvansertib, an investigational drug, is an oral, and a highly selective adenosine triphosphate competitive inhibitor of the serine/threonine PLK1. The Company is developing onvansertib in cancer indications with the greatest medical need for new treatment options. Terms of the agreement provide for the Company to pay development milestones and royalties based on sales volume.
The Company is a party to various agreements under which it licenses technology on an exclusive basis in the field of oncology therapeutics. These agreements include License fees, Royalties and Milestone payments. The Company also has a legacy license agreement in the field of oncology diagnostics under which royalty payments are due. These royalty payments are calculated as a percent of revenue. For the six months ended June 30, 2022 and 2021, payments have not been material.
Litigation
Cardiff Oncology does not believe that it has legal liabilities that are probable or reasonably possible that require either accrual or disclosure. From time to time, the Company may become involved in various lawsuits and legal proceedings that arise in the ordinary course of business. Litigation is subject to inherent uncertainties, and an adverse result in matters may arise from time to time that may harm the Company’s business. As of the date of this report, management believes that there are no claims against the Company, which it believes will result in a material adverse effect on the Company’s business or financial condition.
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ITEM 2. MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS
Forward-Looking Statements
This Quarterly Report on Form 10-Q includes forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended (the “Securities Act”) and Section 21E of the Securities Exchange Act of 1934, as amended (the “Exchange Act”). All statements other than statements of historical facts contained in this Quarterly Report, including statements regarding the future financial position, business strategy and plans and objectives of management for future operations, are forward-looking statements. The words “believe,” “may,” “will,” “estimate,” “continue,” “anticipate,” “intend,” “should,” “plan,” “expect,” and similar expressions, as they relate to us, are intended to identify forward-looking statements. We have based these forward-looking statements largely on current expectations and projections about future events and financial trends that we believe may affect our financial condition, results of operations, business strategy and financial needs. These forward-looking statements are subject to a number of risks, uncertainties and assumptions.
In addition, our business and financial performance may be affected by the factors that are discussed under “Risk Factors” in the Annual Report on Form 10-K for the year ended December 31, 2021, filed on February 24, 2022. Moreover, we operate in a very competitive and rapidly changing environment. New risk factors emerge from time to time and it is not possible for us to predict all risk factors, nor can we assess the impact of all factors on our business or the extent to which any factor, or combination of factors, may cause actual results to differ materially from those contained in any forward-looking statements.
You should not rely upon forward-looking statements as predictions of future events. We cannot assure you that the events and circumstances reflected in the forward-looking statements will be achieved or occur. Although we believe that the expectations reflected in the forward-looking statements are reasonable, we cannot guarantee future results, levels of activity, performance or achievements.
The following discussion and analysis is qualified in its entirety by, and should be read in conjunction with, the more detailed information set forth in the financial statements and the notes thereto appearing elsewhere in this Quarterly Report on Form 10-Q. This discussion should not be construed to imply that the results discussed herein will necessarily continue into the future, or that any conclusion reached herein will necessarily be indicative of actual operating results in the future. Such discussion represents only the best present assessment of our management.
Overview
We are a clinical-stage biotechnology company leveraging PLK1 inhibition to develop novel therapies across a range of cancers with the greatest unmet medical need. Our goal is to target tumor vulnerabilities with treatment combinations that overcome disease resistance, improve disease response to standard treatment regimens and increase overall survival. We are developing onvansertib, an oral and highly selective PLK1 inhibitor, in combination with standard-of-care chemotherapy and targeted therapeutics. Our clinical development programs incorporate tumor genomics and biomarker assays to refine assessment of patient response to treatment.
Our Drug Candidate, Onvansertib
Onvansertib, our lead compound, is a novel, highly potent, highly selective PLK1 inhibitor. PLK1, a serine/threonine kinase, has a well-understood mechanism of action within tumor cell proliferation and is overexpressed in a number of tumors (including colorectal, pancreatic, prostate, ovarian, breast and lung cancer). In particular, PLK1’s activity in various phases of the cell cycle provide multiple targets for a PLK1 inhibitor to inhibit DNA repair and interrupt cell division, thereby killing tumor cells.
PLK1 inhibition has been considered an attractive target of cancer therapeutics for the last two decades, however past PLK1 drug candidates have failed to show acceptable tolerability and efficacy. We believe the attributes of onvansertib described below, as well as clinical evidence of favorable safety and efficacy, with expected on-target, easy to manage and reversible side effects, may prove beneficial in addressing clinical therapeutic needs across a variety of cancers:
•Onvansertib is highly potent and highly selective against the PLK1 enzyme (IC50 = 2nM; IC50 is the concentration for 50% inhibition), compared to prior PLK1 inhibitors that were pan-inhibitors of several PLK targets. Low or no
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activity of onvansertib was observed on a panel of 63 kinases (IC50>500 nM), including the PLK members PLK2 and PLK3 (IC50>10,000 nM).
•Onvansertib has a relatively short drug half-life of 24 hours, compared to a half-life of approximately 5 days for prior PLK1 inhibitors. A short half-life allows for flexible dosing and improved managing of drug concentrations to reduce dose-related toxicities.
•Onvansertib is orally bioavailable, compared to prior PLK1 inhibitors that were delivered intravenously, allowing for relative ease and flexibility of dosing.
In vitro studies have shown synergistic effects when onvansertib was administered in combination with different cytotoxic agents including antimicrotubule agents, topoisomerase 1 inhibitors, antimetabolites, alkylating agents, proteasome inhibitors, kinase inhibitors, BCL-2 inhibitors, and androgen biosynthesis inhibitors.
In addition, in vivo combination studies have confirmed the positive results obtained in vitro and synergistic effects have been observed in xenograft models of onvansertib in combination with irinotecan, 5-fluorouracil ("5-FU"), abiraterone, PARP inhibitors, venetoclax, and paclitaxel, while additive effects in combination with cytarabine or bevacizumab have been demonstrated.
There are three ongoing clinical trials in onvansertib in combination treatment: second line treatment in patients with KRAS-mutated Metastatic Colorectal Cancer ("mCRC"), second line treatment in patients with Metastatic Pancreatic Ductal Adenocarcinoma ("mPDAC"), and in patients with Metastatic Castration-Resistant Prostate Cancer ("mCRPC") showing early signs of resistance to abiraterone.
Phase 1b/2 Clinical Trial in KRAS-mutated mCRC
TROV-054 is a Phase 1b/2 open-label multi-center clinical trial of onvansertib in combination with standard of care FOLFIRI and bevacizumab (Avastin®) for the second line treatment of patients with KRAS-mutated mCRC, which is being conducted at seven clinical trial sites across the U.S. - USC Norris Comprehensive Cancer Center, The Mayo Clinic Cancer Centers (Arizona, Minnesota, and Florida), Kansas University Medical Center, Inova Schar Cancer Institute and CARTI Cancer Center.
The primary objectives of this trial are to evaluate the Dose-Limiting Toxicities ("DLTs"), maximum tolerated dose ("MTD") and recommended Phase 2 dose ("RP2D") of onvansertib in combination with FOLFIRI and bevacizumab (Phase 1b) and to continue to assess the safety and preliminary efficacy of onvansertib in combination with FOLFIRI and bevacizumab (Phase 2).
The scientific rationale for this clinical trial is based on the two key principles of synthetic lethality and synergy, with the objective of demonstrating a proof-of-concept of clinical benefit within this phase1b/2 trial. Synthetic lethality refers to a critical vulnerability to tumor cell death by way of PLK1 inhibition within CRC tumor cells harboring KRAS mutations versus KRAS wild-type isogenic cells. Synergy occurs when the combination of two drugs results in an unexpected greater activity than an expected additive effect of the two drugs. Onvansertib in combination with two DNA-damaging agents, irinotecan, and 5-FU (two components of FOLFIRI), demonstrated synergy in colorectal cancer cell lines and both combinations have demonstrated significantly greater tumor growth inhibition than either drug alone in CRC in vivo models. We believe this synergy occurs because PLK1 can promote the repair of DNA damage caused by chemotherapeutic agents and by inhibiting PLK1, onvansertib leaves damaged tumor cells unable to replicate.
Data we presented on January 18, 2022 provided an update of the ongoing phase 1b/2 clinical trial in KRAS-mutated metastatic colorectal cancer.
•34% (12 of 35) of patients treated per protocol at the RP2D in combination with FOLFIRI and bevacizumab achieved a Complete Response ("CR") or Partial Response ("PR") (CR: 1 patient; PR: 11 patients);
•35% (17 of 48) of patients across all dose levels achieved a CR or PR. Historically, Objective Response Rates ("ORR") of 5-13% have been reported in similar second line patient populations treated with various different drug combinations, including the standard of care chemotherapy of FOLFIRI with bevacizumab;
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•10% (5 of 48) of patients discontinued the trial to pursue potentially curative metastasis-directed therapy (surgical resection or microwave ablation);
•Median Progression-Free Survival ("mPFS") across all response-evaluable patients (n=48) is 9.4 months and has not yet been reached in those treated per protocol at the RP2D. Historically, mPFS of ~4.5-5.7 months has been reported in a similar patient population treated with standard of care chemotherapy of FOLFIRI with bevacizumab;
•The combination regimen of onvansertib plus FOLFIRI/bevacizumab is well tolerated with no major or unexpected toxicities attributed to onvansertib.
Phase 2 Clinical Trial in mPDAC
CRDF-001 is a Phase 2 open-label multi-center clinical trial of onvansertib in combination with nanoliposomal irinotecan (Onivyde®), leucovorin, and fluorouracil for second line treatment of patients with mPDAC, which is being conducted at six clinical trial sites across the U.S. – The Mayo Clinic Cancer Centers (Arizona, Minnesota, and Florida), Kansas University Medical Center, Inova Schar Cancer Institute, and the University of Nebraska Medical Center. The first patient was dosed in June 2021.
The objective of this trial is to assess the safety and preliminary efficacy of onvansertib in combination with nanoliposomal irinotecan (Onyvide®), 5-FU and leucovorin as a second-line treatment in patients with mPDAC who have failed first-line gemcitabine-based therapy. The trial is expected to enroll approximately 45 patients.
Phase 2 Clinical Trial in mCRPC
TROV-053 is a Phase 2 open-label multi-center clinical trial of onvansertib in combination with abiraterone acetate and prednisone in patients with mCRPC, which is being conducted at three clinical trial sites - Beth Israel Deaconess Medical Center, Dana-Farber Cancer Institute and Massachusetts General Hospital. This trial is now closed for enrollment.
The primary objective of this trial is to observe the effects of onvansertib in combination with abiraterone and prednisone on disease control as assessed by Prostate Specific Antigen ("PSA") decline or stabilization after 12 weeks of treatment in patients with mCRPC showing early signs of resistance to abiraterone.
The rationale for this trial is based on the Mechanism of Action ("MOA") of onvansertib and abiraterone acetate and the synergy of these two drugs when used in combination in pre-clinical experiments. Onvansertib inhibits tumor cell proliferation by inducing G2/M (mitosis) arrest and consequently cell death. The combination of onvansertib and abiraterone acetate synergistically increases mitotic arrest and cell death in prostate cancer cells and has demonstrated significantly greater tumor growth inhibition than either drug alone in vivo.
Data presented on April 8, 2022 at American Association for Cancer Research ("AACR") Annual Meeting provided evidence of the safety and efficacy of onvansertib in combination with abiraterone. Disease control increased with increasing dose density of onvansertib from 29% to 45% of patients achieving PSA stabilization and from 53% to 75% of patients with radiographic stable disease; Arm A (n=17) – onvansertib 24mg/m2 days 1-5 in 21-day cycle to Arm C (n=20) – 12mg/m2 days 1-14 in 21-day cycle. Median progression-free survival ("mPFS") increased with increasing onvansertib dose density from 4.1 months in Arm A to 13.2 months as of the data cut-off date in Arm C patients. Genomic analysis of ctDNA showed a correlation between alterations in two key genes of the PI3K signaling pathway—MTOR and PTEN, which appears to underly increased pathway activity, and sensitivity to onvansertib/abiraterone combination in mCRPC patients with early abiraterone resistance. The treatment regimen of onvansertib in combination with abiraterone/prednisone has been well tolerated.
Preclinical Data
On April 8, 2022 we announced the results of preclinical studies evaluating the anti-cancer activity of onvansertib in combination with the PARP inhibitor ("PARPi") olaparib in PARPi-resistant patient-derived xenograft (PDX) ovarian cancer models. The results were featured in a poster presentation at the AACR Annual Meeting.
Data showed the combination of onvansertib and olaparib providing statistically significant survival benefits compared to treatment with either agent alone in three PDX ovarian cancer models. Two of the three PDX models studied were cisplatin-
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sensitive with a mutated BRCA1 gene, while the third was cisplatin-resistant with wild type BRCA1. The onvansertib-olaparib combination was also shown to be well tolerated in mice.
Critical Accounting Policies
Our accounting policies are described in ITEM 7. MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS of our Annual Report on Form 10-K as of and for the year ended December 31, 2021, filed with the SEC on February 24, 2022. There have been no changes to our critical accounting policies since December 31, 2021.
RESULTS OF OPERATIONS
Three Months Ended June 30, 2022 and 2021
Revenues
Total revenues were $91,000 for the three months ended June 30, 2022, as compared to $68,000 for the prior period. Revenues are from our sales-based or usage-based royalties on other intellectual property licenses, unrelated to onvansertib. Revenue recognition of the royalty depends on the timing and overall sales activities of the licensees.
Research and Development Expenses
Research and development expenses consisted of the following:
| Three Months Ended June 30, |
| (in thousands) | 2022 | 2021 | Increase (Decrease) |
| Salaries and staff costs | $ | 1,069 | $ | 292 | $ | 777 |
| Stock-based compensation | 126 | 72 | 54 |
| Clinical trials, outside services, and lab supplies | 5,903 | 3,606 | 2,297 |
| Facilities and other | 350 | 149 | 201 |
| Total research and development | $ | 7,448 | $ | 4,119 | $ | 3,329 |

Research and development expenses increased by $3.3 million for the three months ended June 30, 2022, compared to the same period in 2021. The overall increase in expenses was primarily related to chemistry, manufacturing, and controls ("CMC") and clinical pharmacology for studies to support the development of our lead drug candidate, onvansertib. Salaries and staff costs increased primarily due to additional hires in senior management and our clinical operations team.
Selling, General and Administrative Expenses
Selling, general and administrative expenses consisted of the following:
| Three Months Ended June 30, |
| (in thousands) | 2022 | 2021 | Increase (Decrease) |
| Salaries and staff costs | $ | 792 | $ | 513 | $ | 279 |
| Stock-based compensation | 929 | 964 | (35) |
| Outside services and professional fees | 673 | 914 | (241) |
| Facilities and other | 692 | 447 | 245 |
| Total selling, general and administrative | $ | 3,086 | $ | 2,838 | $ | 248 |

Selling, general and administrative expenses increased by $0.2 million for the three months ended June 30, 2022, compared to the same period in 2021. Salaries and staff costs increased due to merit increases and higher headcount. Facilities and other costs increased due to higher insurance costs and the amending of our operating lease. The decrease in outside services and professional fees was due to recruiting fees incurred for the recruitment of officers and directors in the prior period.
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Net Loss
Net loss and per share amounts were as follows:
| Three Months Ended June 30, |
| (in thousands, except per share amounts) | 2022 | 2021 | Increase (Decrease) |
| Net loss | $ | (10,443) | $ | (6,757) | $ | 3,686 |
| Preferred stock dividend | (6) | (6) | — |
| Net loss attributable to common shareholders | $ | (10,449) | $ | (6,763) | $ | 3,686 |
| Net loss per common share — basic and diluted | $ | (0.24) | $ | (0.17) | $ | 0.07 |
| Weighted average shares outstanding — basic and diluted | 43,306 | 38,761 | 4,545 |

The $3.7 million increase in net loss attributable to common shareholders was primarily the result of an increase of operating expenses for the three months ended June 30, 2022, compared to the same period in the prior year. The $0.07 decrease in net loss per share was impacted by the increase in basic weighted average shares outstanding resulting primarily from the issuance of approximately 3.8 million shares of common stock and common stock equivalents from July 1, 2021 through June 30, 2022.
Six Months Ended June 30, 2022 and 2021
Revenues
Total revenues were $165,000 for the six months ended June 30, 2022, as compared to $140,000 for the prior period. Revenues are from our sales-based or usage-based royalties on other intellectual property licenses, unrelated to onvansertib. Revenue recognition of the royalty depends on the timing and overall sales activities of the licensees.
Research and Development Expenses
Research and development expenses consisted of the following:
| Six Months Ended June 30, |
| (in thousands) | 2022 | 2021 | Increase (Decrease) |
| Salaries and staff costs | $ | 2,130 | $ | 574 | $ | 1,556 |
| Stock-based compensation | 460 | 112 | 348 |
| Clinical trials, outside services, and lab supplies | 11,419 | 6,406 | 5,013 |
| Facilities and other | 647 | 306 | 341 |
| Total research and development | $ | 14,656 | $ | 7,398 | $ | 7,258 |

Research and development expenses increased by $7.3 million for the six months ended June 30, 2022, compared to the same period in 2021. The overall increase in expenses was primarily related to chemistry, manufacturing, and controls ("CMC") and clinical pharmacology for studies to support the development of our lead drug candidate, onvansertib. Salaries and staff costs increased primarily due to additional hires in senior management and our clinical operations team. The increase in stock-based compensation is primarily due to additional stock option grants to employees granted subsequent to the prior period.
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Selling, General and Administrative Expenses
Selling, general and administrative expenses consisted of the following:
| Six Months Ended June 30, |
| (in thousands) | 2022 | 2021 | Increase (Decrease) |
| Salaries and staff costs | $ | 1,652 | $ | 1,081 | $ | 571 |
| Stock-based compensation | 1,747 | 1,192 | 555 |
| Outside services and professional fees | 2,279 | 1,886 | 393 |
| Facilities and other | 1,348 | 914 | 434 |
| Total selling, general and administrative | $ | 7,026 | $ | 5,073 | $ | 1,953 |

Selling, general and administrative expenses increased by $2.0 million for the six months ended June 30, 2022, compared to the same period in 2021. Salaries and staff costs increased due to merit increases and higher headcount. The increase in stock-based compensation is primarily due to additional stock option grants to employees granted subsequent to the prior period. Facilities and other costs increased due to higher insurance costs and the amending of our operating lease.
Net Loss
Net loss and per share amounts were as follows:
| Six Months Ended June 30, |
| (in thousands, except per share amounts) | 2022 | 2021 | Increase (Decrease) |
| Net loss | $ | (21,436) | $ | (11,936) | $ | 9,500 |
| Preferred stock dividend | (12) | (12) | — |
| Net loss attributable to common shareholders | $ | (21,448) | $ | (11,948) | $ | 9,500 |
| Net loss per common share — basic and diluted | $ | (0.50) | $ | (0.31) | $ | 0.19 |
| Weighted average shares outstanding — basic and diluted | 43,269 | 37,967 | 5,302 |

The $9.5 million increase in net loss attributable to common shareholders was primarily the result of an increase in operating expenses for the six months ended June 30, 2022, compared to the same period in the prior year. The $0.19 increase in basic net loss per share was impacted by the increased net loss attributable to common shareholders and the increase in weighted average shares outstanding resulting primarily from the issuance of approximately 3.8 million shares of common stock from July 1, 2021 through June 30, 2022.
LIQUIDITY AND CAPITAL RESOURCES
Net cash used in operating activities for the six months ended June 30, 2022, was $16.9 million, compared to $10.2 million for the six months ended June 30, 2021. Our use of cash was primarily a result of the net loss of $21.4 million for the six months ended June 30, 2022, adjusted for non-cash items related to stock-based compensation of $2.2 million, amortization of premiums on short-term investments of $0.6 million, and release of clinical trial funding commitment of $0.1 million. The net change in our operating assets and liabilities was $1.5 million increasing cash used in operations. At our current and anticipated level of operating loss, we expect to continue to incur an operating cash outflow for the next several years.
Net cash provided by investing activities was $26.0 million primarily related to sales and maturities in excess of purchases of marketable securities during the six months ended June 30, 2022, compared to net cash used in investing activities of $130.7 million for net purchases of marketable securities during the same period in 2021.
Net cash provided in financing activities was $0 during the six months ended June 30, 2022, compared to $20.5 million of proceeds from the sale of common stock and proceeds from warrant exercises for the same period in 2021.
As of June 30, 2022, and December 31, 2021, we had working capital of $118.9 million and $139.6 million, respectively.
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We have incurred net losses since our inception and have negative operating cash flows. As of June 30, 2022, we had $122.0 million in cash, cash equivalents and short-term investments and we believe we have sufficient cash to meet our funding requirements for at least the next 12 months following the issuance date of this Quarterly Report on Form 10-Q.
Our drug development efforts are in their early stages, and we cannot make estimates of the costs or the time that our development efforts will take to complete, or the timing and amount of revenues related to the sale of our drug candidates. The risk of completion of any program is high because of the many uncertainties involved in developing new drug candidates to market, including the long duration of clinical testing, the specific performance of proposed products under stringent clinical trial protocols, extended regulatory approval and review cycles, our ability to raise additional capital, the nature and timing of research and development expenses, and competing technologies being developed by organizations with significantly greater resources.
For the foreseeable future, we expect to continue to incur losses and require additional capital to further advance our clinical trial programs and support our other operations. We cannot be certain that additional funding will be available on acceptable terms, or at all. To the extent that we can raise additional funds by issuing equity securities, our stockholders may experience additional dilution.
ITEM 3. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK
Not applicable.
ITEM 4. CONTROLS AND PROCEDURES
Evaluation of Disclosure Controls and Procedures
We have performed an evaluation under the supervision and with the participation of our management, including our principal executive officer (CEO) and principal financial officer (CFO), of the effectiveness of our disclosure controls and procedures, as defined in Rule 13a-15(e) and 15d-15(e) under the Securities Exchange Act of 1934, as amended (the “Exchange Act”). Based on that evaluation, our principal executive officer and principal financial officer concluded that our disclosure controls and procedures were effective as of June 30, 2022, to provide reasonable assurance that information required to be disclosed by us in the reports filed or submitted by us under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the SEC’s rules and forms.
Our disclosure controls and procedures are designed to provide reasonable assurance of achieving their objectives as specified above. Management does not expect, however, that our disclosure controls and procedures will prevent or detect all errors and fraud. Any control system, no matter how well designed and operated, is based upon certain assumptions and can provide only reasonable, not absolute, assurance that its objectives will be met. Further, no evaluation of controls can provide absolute assurance that misstatements due to error or fraud will not occur or that all control issues and instances of fraud, if any, within our company have been detected.
Changes in Internal Control over Financial Reporting
There was no change in our internal control over financial reporting during the three months ended June 30, 2022, that materially affected, or is reasonably likely to materially affect, our internal control over financial reporting.
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PART II. OTHER INFORMATION
ITEM 1. LEGAL PROCEEDINGS
None.
ITEM 1A. RISK FACTORS
There have been no material changes from the risk factors disclosed in our Form 10-K for the year ended December 31, 2021.
ITEM 2. UNREGISTERED SALES OF EQUITY SECURITIES AND USE OF PROCEEDS
None.
ITEM 3. DEFAULTS UPON SENIOR SECURITIES
None.
ITEM 4. MINE SAFETY DISCLOSURES
Not applicable.
ITEM 5. OTHER INFORMATION
None.
ITEM 6. EXHIBITS
| ExhibitNumber | Description of Exhibit |
| 31.1 | Certification of Principal Executive Officer required by Rule 13a-14(a)/15d-14(a) under the Exchange Act. |
| 31.2 | Certification of Principal Financial Officer required by Rule 13a-14(a)/15d-14(a) under the Exchange Act. |
| 32.1 | Certification of Principal Executive Officer pursuant to 18 U.S.C Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002. |
| 32.2 | Certification of Principal Financial Officer pursuant to 18 U.S.C Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002. |
| 101.INS | Inline XBRL Instance Document |
| 101.SCH | Inline XBRL Taxonomy Extension Schema |
| 101.CAL | Inline XBRL Taxonomy Extension Calculation Linkbase |
| 101.LAB | Inline XBRL Taxonomy Extension Labels Linkbase |
| 101.PRE | Inline XBRL Taxonomy Extension Presentation Linkbase |
| 101.DEF | Inline XBRL Taxonomy Extension Definition Linkbase |
| 104 | Cover Page Interactive Data File - the cover page from the Registrant’s Quarterly Report on Form 10-Q for the quarter ended June 30, 2022, is formatted in Inline XBRL |

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SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.
| CARDIFF ONCOLOGY, INC. |
| August 4, 2022 | By: | /s/ Mark Erlander |
| Mark Erlander |
| Chief Executive Officer |
| CARDIFF ONCOLOGY, INC. |
| August 4, 2022 | By: | /s/ James Levine |
| James Levine |
| Chief Financial Officer |

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Question: Calculate the change in the company's quick ratio from December 31, 2021 to June 30, 2022 in ratio.

Python solution:
def solution():
    #Define variables name and value
    cash_and_cash_equivalent_dec = 11943
    short_term_investments_dec = 128878
    accounts_receivable_dec = 535
    current_liabilities_dec = 6559
    cash_and_cash_equivalent_june = 20965 
    short_term_investments_june = 101041
    accounts_receivable_june = 551
    current_liabilities_june = 8481

    #Do math calculation to get the answer
    quick_ratio_dec = (cash_and_cash_equivalent_dec + short_term_investments_dec + accounts_receivable_dec) / current_liabilities_dec
    quick_ratio_june = (cash_and_cash_equivalent_june + short_term_investments_june + accounts_receivable_june) / current_liabilities_june
    answer = quick_ratio_june - quick_ratio_dec
    return answer


Answer: -7.1006837001