[ { "question": "What proteins does the protein P11310 interact with?", "source": "P11310", "entities": { "protein": "P11310" }, "answer": [ { "name": "ACADM", "answer": "P11310" } ], "type": "one-hop" }, { "question": "Could you please specify which proteins the protein P30153 interacts with?", "source": "P30153", "entities": { "protein": "P30153" }, "answer": [ { "name": "MARK4", "answer": "Q96L34" } ], "type": "one-hop" }, { "question": "Can you identify proteins that the protein P63261 show interaction with?", "source": "P63261", "entities": { "protein": "P63261" }, "answer": [ { "name": "GRB2", "answer": "P62993" } ], "type": "one-hop" }, { "question": "I'm curious, which proteins does the protein Q9BZC7 interact with?", "source": "Q9BZC7", "entities": { "protein": "Q9BZC7" }, "answer": [ { "name": "CDK5RAP2", "answer": "Q96SN8" } ], "type": "one-hop" }, { "question": "Do you know what proteins does the protein Q9Y3L3 interact with?", "source": "Q9Y3L3", "entities": { "protein": "Q9Y3L3" }, "answer": [ { "name": "HCK", "answer": "P08631" } ], "type": "one-hop" }, { "question": "What proteins does the protein Q9NRA8 interact with?", "source": "Q9NRA8", "entities": { "protein": "Q9NRA8" }, "answer": [ { "name": "EIF4E", "answer": "P06730" }, { "name": "KPNB1", "answer": "Q14974" }, { "name": "CSE1L", "answer": "P55060" } ], "type": "one-hop" }, { "question": "Could you please specify which proteins the protein Q9H013 interacts with?", "source": "Q9H013", "entities": { "protein": "Q9H013" }, "answer": [ { "name": "UBC", "answer": "P0CG48" }, { "name": "ABI2", "answer": "Q9NYB9" }, { "name": "ESF1", "answer": "Q9H501" } ], "type": "one-hop" }, { "question": "Can you identify proteins that the protein P68032 show interaction with?", "source": "P68032", "entities": { "protein": "P68032" }, "answer": [ { "name": "GRB2", "answer": "P62993" } ], "type": "one-hop" }, { "question": "I'm curious, which proteins does the protein P78536 interact with?", "source": "P78536", "entities": { "protein": "P78536" }, "answer": [ { "name": "MAD2L1", "answer": "Q13257" } ], "type": "one-hop" }, { "question": "Do you know what proteins does the protein P01011 interact with?", "source": "P01011", "entities": { "protein": "P01011" }, "answer": [ { "name": "DNAJC1", "answer": "Q96KC8" } ], "type": "one-hop" }, { "question": "What proteins does the protein Q13541 interact with?", "source": "Q13541", "entities": { "protein": "Q13541" }, "answer": [ { "name": "EIF4E", "answer": "P06730" }, { "name": "EIF4E2", "answer": "O60573" } ], "type": "one-hop" }, { "question": "Could you please specify which proteins the protein P78314 interacts with?", "source": "P78314", "entities": { "protein": "P78314" }, "answer": [ { "name": "YWHAQ", "answer": "P27348" } ], "type": "one-hop" }, { "question": "Can you identify proteins that the protein O60516 show interaction with?", "source": "O60516", "entities": { "protein": "O60516" }, "answer": [ { "name": "EIF4E", "answer": "P06730" } ], "type": "one-hop" }, { "question": "I'm curious, which proteins does the protein Q7L8J4 interact with?", "source": "Q7L8J4", "entities": { "protein": "Q7L8J4" }, "answer": [ { "name": "YWHAG", "answer": "P61981" } ], "type": "one-hop" }, { "question": "Do you know what proteins does the protein Q9NY61 interact with?", "source": "Q9NY61", "entities": { "protein": "Q9NY61" }, "answer": [ { "name": "MAPT", "answer": "P10636" }, { "name": "SP1", "answer": "P08047" }, { "name": "RBBP8", "answer": "Q99708" }, { "name": "POLR2J", "answer": "P52435" } ], "type": "one-hop" }, { "question": "What proteins does the protein P35609 interact with?", "source": "P35609", "entities": { "protein": "P35609" }, "answer": [ { "name": "KCNA4", "answer": "P22459" }, { "name": "LRP12", "answer": "Q9Y561" }, { "name": "MYOZ1", "answer": "Q9NP98" }, { "name": "KCNA5", "answer": "P22460" } ], "type": "one-hop" }, { "question": "Could you please specify which proteins the protein P42025 interacts with?", "source": "P42025", "entities": { "protein": "P42025" }, "answer": [ { "name": "ACTB", "answer": "P60709" }, { "name": "DCTN1", "answer": "Q14203" } ], "type": "one-hop" }, { "question": "Can you identify proteins that the protein P28288 show interaction with?", "source": "P28288", "entities": { "protein": "P28288" }, "answer": [ { "name": "ABCD1", "answer": "P33897" }, { "name": "ABCD3", "answer": "P28288" } ], "type": "one-hop" }, { "question": "I'm curious, which proteins does the protein Q9UKV3 interact with?", "source": "Q9UKV3", "entities": { "protein": "Q9UKV3" }, "answer": [ { "name": "YWHAG", "answer": "P61981" }, { "name": "MED19", "answer": "A0JLT2" }, { "name": "YWHAB", "answer": "P31946" } ], "type": "one-hop" }, { "question": "Do you know what proteins does the protein O94929 interact with?", "source": "O94929", "entities": { "protein": "O94929" }, "answer": [ { "name": "GRB2", "answer": "P62993" } ], "type": "one-hop" }, { "question": "What proteins does the protein O14639 interact with?", "source": "O14639", "entities": { "protein": "O14639" }, "answer": [ { "name": "GRB2", "answer": "P62993" } ], "type": "one-hop" }, { "question": "Could you please specify which proteins the protein Q13542 interacts with?", "source": "Q13542", "entities": { "protein": "Q13542" }, "answer": [ { "name": "EIF4E", "answer": "P06730" } ], "type": "one-hop" }, { "question": "Can you identify proteins that the protein O43707 show interaction with?", "source": "O43707", "entities": { "protein": "O43707" }, "answer": [ { "name": "GRB2", "answer": "P62993" } ], "type": "one-hop" }, { "question": "I'm curious, which proteins does the protein P33897 interact with?", "source": "P33897", "entities": { "protein": "P33897" }, "answer": [ { "name": "ABCD3", "answer": "P28288" }, { "name": "ABCD1", "answer": "P33897" } ], "type": "one-hop" }, { "question": "Do you know what proteins does the protein Q14738 interact with?", "source": "Q14738", "entities": { "protein": "Q14738" }, "answer": [ { "name": "NEK1", "answer": "Q96PY6" } ], "type": "one-hop" }, { "question": "What proteins does the protein P02768 interact with?", "source": "P02768", "entities": { "protein": "P02768" }, "answer": [ { "name": "YWHAG", "answer": "P61981" } ], "type": "one-hop" }, { "question": "Could you please specify which proteins the protein Q92667 interacts with?", "source": "Q92667", "entities": { "protein": "Q92667" }, "answer": [ { "name": "PRKAR1A", "answer": "P10644" } ], "type": "one-hop" }, { "question": "Can you identify proteins that the protein P49418 show interaction with?", "source": "P49418", "entities": { "protein": "P49418" }, "answer": [ { "name": "DNM3", "answer": "Q9UQ16" }, { "name": "DNM1", "answer": "Q05193" }, { "name": "SYNJ1", "answer": "O43426" }, { "name": "DNM2", "answer": "P50570" } ], "type": "one-hop" }, { "question": "I'm curious, which proteins does the protein O95831 interact with?", "source": "O95831", "entities": { "protein": "O95831" }, "answer": [ { "name": "MED29", "answer": "Q9NX70" } ], "type": "one-hop" }, { "question": "Do you know what proteins does the protein O75077 interact with?", "source": "O75077", "entities": { "protein": "O75077" }, "answer": [ { "name": "YWHAZ", "answer": "P63104" } ], "type": "one-hop" }, { "question": "What proteins does the protein Q9Y243 interact with?", "source": "Q9Y243", "entities": { "protein": "Q9Y243" }, "answer": [ { "name": "CDC37", "answer": "Q16543" } ], "type": "one-hop" }, { "question": "Could you please specify which proteins the protein Q96Q42 interacts with?", "source": "Q96Q42", "entities": { "protein": "Q96Q42" }, "answer": [ { "name": "YWHAB", "answer": "P31946" } ], "type": "one-hop" }, { "question": "Can you identify proteins that the protein Q9NWT8 show interaction with?", "source": "Q9NWT8", "entities": { "protein": "Q9NWT8" }, "answer": [ { "name": "AURKA", "answer": "O14965" } ], "type": "one-hop" }, { "question": "I'm curious, which proteins does the protein P31751 interact with?", "source": "P31751", "entities": { "protein": "P31751" }, "answer": [ { "name": "CDC37", "answer": "Q16543" } ], "type": "one-hop" }, { "question": "Do you know what proteins does the protein Q13443 interact with?", "source": "Q13443", "entities": { "protein": "Q13443" }, "answer": [ { "name": "SH3GL2", "answer": "Q99962" }, { "name": "PACSIN3", "answer": "Q9UKS6" }, { "name": "MAD2L2", "answer": "Q9UI95" } ], "type": "one-hop" }, { "question": "What proteins does the protein P07550 interact with?", "source": "P07550", "entities": { "protein": "P07550" }, "answer": [ { "name": "EIF2B1", "answer": "Q14232" } ], "type": "one-hop" }, { "question": "Could you please specify which proteins the protein P52594 interacts with?", "source": "P52594", "entities": { "protein": "P52594" }, "answer": [ { "name": "EPS15", "answer": "P42566" } ], "type": "one-hop" }, { "question": "Can you identify proteins that the protein Q16352 show interaction with?", "source": "Q16352", "entities": { "protein": "Q16352" }, "answer": [ { "name": "STAU1", "answer": "O95793" } ], "type": "one-hop" }, { "question": "I'm curious, which proteins does the protein O95433 interact with?", "source": "O95433", "entities": { "protein": "O95433" }, "answer": [ { "name": "HSP90AA1", "answer": "P07900" } ], "type": "one-hop" }, { "question": "Do you know what proteins does the protein P12235 interact with?", "source": "P12235", "entities": { "protein": "P12235" }, "answer": [ { "name": "GRB2", "answer": "P62993" } ], "type": "one-hop" }, { "question": "What proteins does the protein Q9P0K1 interact with?", "source": "Q9P0K1", "entities": { "protein": "Q9P0K1" }, "answer": [ { "name": "YWHAZ", "answer": "P63104" } ], "type": "one-hop" }, { "question": "Could you please specify which proteins the protein O75689 interacts with?", "source": "O75689", "entities": { "protein": "O75689" }, "answer": [ { "name": "CSNK1A1", "answer": "P48729" } ], "type": "one-hop" }, { "question": "Can you identify proteins that the protein P35869 show interaction with?", "source": "P35869", "entities": { "protein": "P35869" }, "answer": [ { "name": "ARNT", "answer": "P27540" }, { "name": "NCOR2", "answer": "Q9Y618" }, { "name": "NCOA7", "answer": "Q8NI08" } ], "type": "one-hop" }, { "question": "I'm curious, which proteins does the protein P55789 interact with?", "source": "P55789", "entities": { "protein": "P55789" }, "answer": [ { "name": "GPS1", "answer": "Q13098" }, { "name": "COPS5", "answer": "Q92905" }, { "name": "COPS8", "answer": "Q99627" }, { "name": "COPS2", "answer": "P61201" } ], "type": "one-hop" }, { "question": "Do you know what proteins does the protein Q9UHB7 interact with?", "source": "Q9UHB7", "entities": { "protein": "Q9UHB7" }, "answer": [ { "name": "MED26", "answer": "O95402" }, { "name": "MED19", "answer": "A0JLT2" }, { "name": "MED10", "answer": "Q9BTT4" } ], "type": "one-hop" }, { "question": "What proteins does the protein Q12802 interact with?", "source": "Q12802", "entities": { "protein": "Q12802" }, "answer": [ { "name": "YWHAB", "answer": "P31946" }, { "name": "YWHAG", "answer": "P61981" } ], "type": "one-hop" }, { "question": "Could you please specify which proteins the protein Q8TCU4 interacts with?", "source": "Q8TCU4", "entities": { "protein": "Q8TCU4" }, "answer": [ { "name": "MEGF10", "answer": "Q96KG7" } ], "type": "one-hop" }, { "question": "Can you identify proteins that the protein O60241 show interaction with?", "source": "O60241", "entities": { "protein": "O60241" }, "answer": [ { "name": "STARD13", "answer": "Q9Y3M8" } ], "type": "one-hop" }, { "question": "I'm curious, which proteins does the protein P58335 interact with?", "source": "P58335", "entities": { "protein": "P58335" }, "answer": [ { "name": "ANTXR2", "answer": "P58335" } ], "type": "one-hop" }, { "question": "Do you know what proteins does the protein Q96CW1 interact with?", "source": "Q96CW1", "entities": { "protein": "Q96CW1" }, "answer": [ { "name": "RRP12", "answer": "Q5JTH9" }, { "name": "MEGF10", "answer": "Q96KG7" }, { "name": "GRB2", "answer": "P62993" }, { "name": "RALBP1", "answer": "Q15311" } ], "type": "one-hop" }, { "question": "What's the amino acid sequence of O76096?", "source": "O76096", "entities": { "protein": "O76096" }, "answer": [ { "answer": "MRAAGTLLAFCCLVLSTTGGPSPDTCSQDLNSRVKPGFPKTIKTNDPGVLQAARYSVEKFNNCTNDMFLFKESRITRALVQIVKGLKYMLEVEIGRTTCKKNQHLRLDDCDFQTNHTLKQTLSCYSEVWVVPWLQHFEVPVLRCH", "header": "sp|O76096|CYTF_HUMAN", "source": "UniProt", "size": "145" } ], "type": "one-hop" }, { "question": "Can you provide the amino acid sequence of P0DP01?", "source": "P0DP01", "entities": { "protein": "P0DP01" }, "answer": [ { "answer": "MDWTWRILFLVAAATSAHSQVQLVQSGAEVKKPGASVKVSCKASGYTFTSYDINWVRQATGQGLEWMGWMNPNSGNTGYAQKFQGRVTMTRNTSISTAYMELSSLRSEDTAVYYCAR", "header": "sp|P0DP01|HV108_HUMAN", "source": "UniProt", "size": "117" } ], "type": "one-hop" }, { "question": "Could you tell me the amino acid sequence of P16402?", "source": "P16402", "entities": { "protein": "P16402" }, "answer": [ { "answer": "MSETAPLAPTIPAPAEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAKKAGAAKPRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKVKTPQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAKKAAPKKK", "header": "sp|P16402|H13_HUMAN", "source": "UniProt", "size": "221" } ], "type": "one-hop" }, { "question": "Please identify the amino acid sequence of P57053.", "source": "P57053", "entities": { "protein": "P57053" }, "answer": [ { "answer": "MPEPAKSAPAPKKGSKKAVTKAQKKDGRKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLPHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSAK", "header": "sp|P57053|H2BFS_HUMAN", "source": "UniProt", "size": "126" } ], "type": "one-hop" }, { "question": "Can you display the amino acid sequence that constitutes P59190?", "source": "P59190", "entities": { "protein": "P59190" }, "answer": [ { "answer": "MAKQYDVLFRLLLIGDSGVGKTCLLCRFTDNEFHSSHISTIGVDFKMKTIEVDGIKVRIQIWDTAGQERYQTITKQYYRRAQGIFLVYDISSERSYQHIMKWVSDVDEYAPEGVQKILIGNKADEEQKRQVGREQGQQLAKEYGMDFYETSACTNLNIKESFTRLTELVLQAHRKELEGLRMRASNELALAELEEEEGKPEGPANSSKTCWC", "header": "sp|P59190|RAB15_HUMAN", "source": "UniProt", "size": "212" } ], "type": "one-hop" }, { "question": "What's the amino acid sequence of Q07020?", "source": "Q07020", "entities": { "protein": "Q07020" }, "answer": [ { "answer": "MGVDIRHNKDRKVRRKEPKSQDIYLRLLVKLYRFLARRTNSTFNQVVLKRLFMSRTNRPPLSLSRMIRKMKLPGRENKTAVVVGTITDDVRVQEVPKLKVCALRVTSRARSRILRAGGKILTFDQLALDSPKGCGTVLLSGPRKGREVYRHFGKAPGTPHSHTKPYVRSKGRKFERARGRRASRGYKN", "header": "sp|Q07020|RL18_HUMAN", "source": "UniProt", "size": "188" } ], "type": "one-hop" }, { "question": "Can you provide the amino acid sequence of Q15834?", "source": "Q15834", "entities": { "protein": "Q15834" }, "answer": [ { "answer": "MEAEAGGLEELTDEEMAALGKEELVRRLRREEAARLAALVQRGRLMQEVNRQLQGHLGEIRELKQLNRRLQAENRELRDLCCFLDSERQRGRRAARQWQLFGTQASRAVREDLGGCWQKLAELEGRQEELLRENLALKELCLALGEEWGPRGGPSGAGGSGAGPAPELALPPCGPRDLGDGSSSTGSVGSPDQLPLACSPDD", "header": "sp|Q15834|CC85B_HUMAN", "source": "UniProt", "size": "202" } ], "type": "one-hop" }, { "question": "Could you tell me the amino acid sequence of Q30KQ8?", "source": "Q30KQ8", "entities": { "protein": "Q30KQ8" }, "answer": [ { "answer": "MKLLTTICRLKLEKMYSKTNTSSTIFEKARHGTEKISTARSEGHHITFSRWKSCTAIGGRCKNQCDDSEFRISYCARPTTHCCVTECDPTDPNNWIPKDSVGTQEWYPKDSRH", "header": "sp|Q30KQ8|DB112_HUMAN", "source": "UniProt", "size": "113" } ], "type": "one-hop" }, { "question": "Please identify the amino acid sequence of Q3MIV0.", "source": "Q3MIV0", "entities": { "protein": "Q3MIV0" }, "answer": [ { "answer": "MSFDNNYHGGQGYAKGGLGCSYGCGLSGYGYACYCPWCYERSWFSGCF", "header": "sp|Q3MIV0|KR221_HUMAN", "source": "UniProt", "size": "48" } ], "type": "one-hop" }, { "question": "Can you display the amino acid sequence that constitutes Q5STR5?", "source": "Q5STR5", "entities": { "protein": "Q5STR5" }, "answer": [ { "answer": "MAEEGDVDEADVFLAFAQGPSPPRGPVRRALDKAFFIFLALFLTLLMLEAAYKLLWLLLWAKLGDWLLGTPQKEEELEL", "header": "sp|Q5STR5|SIM40_HUMAN", "source": "UniProt", "size": "79" } ], "type": "one-hop" }, { "question": "What's the amino acid sequence of Q6ZRR5?", "source": "Q6ZRR5", "entities": { "protein": "Q6ZRR5" }, "answer": [ { "answer": "MALALCLQVLCSLCGWLSLYISFCHLNKHRSYEWSCRLVTFTHGVLSIGLSAYIGFIDGPWPFTHPGSPNTPLQVHVLCLTLGYFIFDLGWCVYFQSEGALMLAHHTLSILGIIMALVLGESGTEVNAVLFGSELTNPLLQMRWFLRETGHYHSFTGDVVDFLFVALFTGVRIGVGACLLFCEMVSPTPKWFVKAGGVAMYAVSWCFMFSIWRFAWRKSIKKYHAWRSRRSEERQLKHNGHLKIH", "header": "sp|Q6ZRR5|TLCD5_HUMAN", "source": "UniProt", "size": "245" } ], "type": "one-hop" }, { "question": "Can you provide the amino acid sequence of Q86T20?", "source": "Q86T20", "entities": { "protein": "Q86T20" }, "answer": [ { "answer": "MSNTTVPNAPQANSDSMVGYVLGPFFLITLVGVVVAVVMYVQKKKRVDRLRHHLLPMYSYDPAEELHEAEQELLSDMGDPKVVHGWQSGYQHKRMPLLDVKT", "header": "sp|Q86T20|SIM29_HUMAN", "source": "UniProt", "size": "102" } ], "type": "one-hop" }, { "question": "Could you tell me the amino acid sequence of Q86WS3?", "source": "Q86WS3", "entities": { "protein": "Q86WS3" }, "answer": [ { "answer": "MALEVLMLLAVLIWTGAENLHVKISCSLDWLMVSVIPVAESRNLYIFADELHLGMGCPANRIHTYVYEFIYLVRDCGIRTRVVSEETLLFQTELYFTPRNIDHDPQEIHLECSTSRKSVWLTPVSTENEIKLDPSPFIADFQTTAEELGLLSSSPNLL", "header": "sp|Q86WS3|OOSP2_HUMAN", "source": "UniProt", "size": "158" } ], "type": "one-hop" }, { "question": "Please identify the amino acid sequence of Q8N5X7.", "source": "Q8N5X7", "entities": { "protein": "Q8N5X7" }, "answer": [ { "answer": "MALPPAAAPPAGAREPPGSRAAAAAAAPEPPLGLQQLSALQPEPGGVPLHSSWTFWLDRSLPGATAAECASNLKKIYTVQTVQIFWSVYNNIPPVTSLPLRCSYHLMRGERRPLWEEESNAKGGVWKMKVPKDSTSTVWKELLLATIGEQFTDCAAADDEVIGVSVSVRDREDVVQVWNVNASLVGEATVLEKIYELLPHITFKAVFYKPHEEHHAFEGGRGKH", "header": "sp|Q8N5X7|IF4E3_HUMAN", "source": "UniProt", "size": "224" } ], "type": "one-hop" }, { "question": "Can you display the amino acid sequence that constitutes Q8N813?", "source": "Q8N813", "entities": { "protein": "Q8N813" }, "answer": [ { "answer": "MGTGASEKQAEQKVRRAFEASEEAHGTLAASTPWVAMGSAYGSCTCLGAQPVTDLALWPVIYSCMGFSPQAYPAFWAYPWVLYGGYLWMGYPPPAALVPSVWLYWRGASSFDPLIGSPYLAALAPNLFPFPMKFPPTYSLASPTLGGATSSHCPQVGCWTPASSAPRAAVEGPSRGAPYLKTCKAPPSEWASRFGIWAPLPCCSSELRPLPPSPIEDSQLDPGCSRSSSRSPCRARRRLFEC", "header": "sp|Q8N813|PR23E_HUMAN", "source": "UniProt", "size": "242" } ], "type": "one-hop" }, { "question": "What's the amino acid sequence of Q92928?", "source": "Q92928", "entities": { "protein": "Q92928" }, "answer": [ { "answer": "MNPGYDCLFKLLLIGDSGVGKSCLLLRFADDPYTESYISTIGVDFKIQTIELDGKTIKLQIWDTAGQERFWTITSSYYRGAHGFLVVYDVTDQESYANVKQWLQEIDRHASENVNKLLVGNKSDLTTKKVVDNTTAKEFADSLGIPFLETSAKNATNVEQAFMTMAAEIKKQMGPGAASGGERPNLKIDSTPVKPAGGGCC", "header": "sp|Q92928|RAB1C_HUMAN", "source": "UniProt", "size": "201" } ], "type": "one-hop" }, { "question": "Can you provide the amino acid sequence of Q96DE0?", "source": "Q96DE0", "entities": { "protein": "Q96DE0" }, "answer": [ { "answer": "MAGARRLELGEALALGSGWRHACHALLYAPDPGMLFGRIPLRYAILMQMRFDGRLGFPGGFVDTQDRSLEDGLNRELREELGEAAAAFRVERTDYRSSHVGSGPRVVAHFYAKRLTLEELLAVEAGATRAKDHGLEVLGLVRVPLYTLRDGVGGLPTFLENSFIGSAREQLLEALQDLGLLQSGSISGLKIPAHH", "header": "sp|Q96DE0|NUD16_HUMAN", "source": "UniProt", "size": "195" } ], "type": "one-hop" }, { "question": "Could you tell me the amino acid sequence of Q96GX8?", "source": "Q96GX8", "entities": { "protein": "Q96GX8" }, "answer": [ { "answer": "MGLKMSCLKGFQMCVSSSSSSHDEAPVLNDKHLDVPDIIITPPTPTGMMLPRDLGSTVWLDETGSCPDDGEIDPEA", "header": "sp|Q96GX8|CP074_HUMAN", "source": "UniProt", "size": "76" } ], "type": "one-hop" }, { "question": "Please identify the amino acid sequence of Q9BRX8.", "source": "Q9BRX8", "entities": { "protein": "Q9BRX8" }, "answer": [ { "answer": "MSFLQDPSFFTMGMWSIGAGALGAAALALLLANTDVFLSKPQKAALEYLEDIDLKTLEKEPRTFKAKELWEKNGAVIMAVRRPGCFLCREEAADLSSLKSMLDQLGVPLYAVVKEHIRTEVKDFQPYFKGEIFLDEKKKFYGPQRRKMMFMGFIRLGVWYNFFRAWNGGFSGNLEGEGFILGGVFVVGSGKQGILLEHREKEFGDKVNLLSVLEAAKMIKPQTLASEKK", "header": "sp|Q9BRX8|PXL2A_HUMAN", "source": "UniProt", "size": "229" } ], "type": "one-hop" }, { "question": "Can you display the amino acid sequence that constitutes Q9BVV7?", "source": "Q9BVV7", "entities": { "protein": "Q9BVV7" }, "answer": [ { "answer": "MICTFLRAVQYTEKLHRSSAKRLLLPYIVLNKACLKTEPSLRCGLQYQKKTLRPRCILGVTQKTIWTQGPSPRKAKEDGSKQVSVHRSQRGGTAVPTSQKVKEAGRDFTYLIVVLFGISITGGLFYTIFKELFSSSSPSKIYGRALEKCRSHPEVIGVFGESVKGYGEVTRRGRRQHVRFTEYVKDGLKHTCVKFYIEGSEPGKQGTVYAQVKENPGSGEYDFRYIFVEIESYPRRTIIIEDNRSQDD", "header": "sp|Q9BVV7|TIM21_HUMAN", "source": "UniProt", "size": "248" } ], "type": "one-hop" }, { "question": "What's the amino acid sequence of Q9NRY2?", "source": "Q9NRY2", "entities": { "protein": "Q9NRY2" }, "answer": [ { "answer": "MAANSSGQGFQNKNRVAILAELDKEKRKLLMQNQSSTNHPGASIALSRPSLNKDFRDHAEQQHIAAQQKAALQHAHAHSSGYFITQDSAFGNLILPVLPRLDPE", "header": "sp|Q9NRY2|SOSSC_HUMAN", "source": "UniProt", "size": "104" } ], "type": "one-hop" }, { "question": "Can you provide the amino acid sequence of Q9P2X8?", "source": "Q9P2X8", "entities": { "protein": "Q9P2X8" }, "answer": [ { "answer": "MLCVSGFTSNLYSSKKDDKMKEISRTSNWGSSFSEKSGCMQTHPSMNLDCRDVTYVMNLLLIAHHHLLQ", "header": "sp|Q9P2X8|CI027_HUMAN", "source": "UniProt", "size": "69" } ], "type": "one-hop" }, { "question": "Could you tell me the amino acid sequence of A0A075B6I9?", "source": "A0A075B6I9", "entities": { "protein": "A0A075B6I9" }, "answer": [ { "answer": "MAWTPLFLFLLTCCPGSNSQAVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGHYPYWFQQKPGQAPRTLIYDTSNKHSWTPARFSGSLLGGKAALTLLGAQPEDEAEYYCLLSYSGAR", "header": "sp|A0A075B6I9|LV746_HUMAN", "source": "UniProt", "size": "117" } ], "type": "one-hop" }, { "question": "Please identify the amino acid sequence of A0A096LP55.", "source": "A0A096LP55", "entities": { "protein": "A0A096LP55" }, "answer": [ { "answer": "MGLEDEQKMLTESGDPEEEEEEEEELVDPLTTVREQCEQLEKCVKARERLELYDEHVSSRSHTEEDCTEELFDFLHAKDHCVAHKLFNNLK", "header": "sp|A0A096LP55|QCR6L_HUMAN", "source": "UniProt", "size": "91" } ], "type": "one-hop" }, { "question": "Can you display the amino acid sequence that constitutes A0A1B0GUI7?", "source": "A0A1B0GUI7", "entities": { "protein": "A0A1B0GUI7" }, "answer": [ { "answer": "MSGRVPLAEKALSEGYARLRYRDTSLLIWQQQQQKLESVPPGTYLSRSRSMWYSQYGNEAILVRDKNKLEVSRDTGQSKFCTIM", "header": "sp|A0A1B0GUI7|BRDOS_HUMAN", "source": "UniProt", "size": "84" } ], "type": "one-hop" }, { "question": "What's the amino acid sequence of O00161?", "source": "O00161", "entities": { "protein": "O00161" }, "answer": [ { "answer": "MDNLSSEEIQQRAHQITDESLESTRRILGLAIESQDAGIKTITMLDEQKEQLNRIEEGLDQINKDMRETEKTLTELNKCCGLCVCPCNRTKNFESGKAYKTTWGDGGENSPCNVVSKQPGPVTNGQLQQPTTGAASGGYIKRITNDAREDEMEENLTQVGSILGNLKDMALNIGNEIDAQNPQIKRITDKADTNRDRIDIANARAKKLIDS", "header": "sp|O00161|SNP23_HUMAN", "source": "UniProt", "size": "211" } ], "type": "one-hop" }, { "question": "Can you provide the amino acid sequence of O95445?", "source": "O95445", "entities": { "protein": "O95445" }, "answer": [ { "answer": "MFHQIWAALLYFYGIILNSIYQCPEHSQLTTLGVDGKEFPEVHLGQWYFIAGAAPTKEELATFDPVDNIVFNMAAGSAPMQLHLRATIRMKDGLCVPRKWIYHLTEGSTDLRTEGRPDMKTELFSSSCPGGIMLNETGQGYQRFLLYNRSPHPPEKCVEEFKSLTSCLDSKAFLLTPRNQEACELSNN", "header": "sp|O95445|APOM_HUMAN", "source": "UniProt", "size": "188" } ], "type": "one-hop" }, { "question": "Could you tell me the amino acid sequence of P01036?", "source": "P01036", "entities": { "protein": "P01036" }, "answer": [ { "answer": "MARPLCTLLLLMATLAGALASSSKEENRIIPGGIYDADLNDEWVQRALHFAISEYNKATEDEYYRRPLQVLRAREQTFGGVNYFFDVEVGRTICTKSQPNLDTCAFHEQPELQKKQLCSFEIYEVPWEDRMSLVNSRCQEA", "header": "sp|P01036|CYTS_HUMAN", "source": "UniProt", "size": "141" } ], "type": "one-hop" }, { "question": "Please identify the amino acid sequence of P04216.", "source": "P04216", "entities": { "protein": "P04216" }, "answer": [ { "answer": "MNLAISIALLLTVLQVSRGQKVTSLTACLVDQSLRLDCRHENTSSSPIQYEFSLTRETKKHVLFGTVGVPEHTYRSRTNFTSKYNMKVLYLSAFTSKDEGTYTCALHHSGHSPPISSQNVTVLRDKLVKCEGISLLAQNTSWLLLLLLSLSLLQATDFMSL", "header": "sp|P04216|THY1_HUMAN", "source": "UniProt", "size": "161" } ], "type": "one-hop" }, { "question": "Can you display the amino acid sequence that constitutes P04432?", "source": "P04432", "entities": { "protein": "P04432" }, "answer": [ { "answer": "MDMRVPAQLLGLLLLWLRGARCDIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSTP", "header": "sp|P04432|KVD39_HUMAN", "source": "UniProt", "size": "117" } ], "type": "one-hop" }, { "question": "What's the amino acid sequence of P07305?", "source": "P07305", "entities": { "protein": "P07305" }, "answer": [ { "answer": "MTENSTSAPAAKPKRAKASKKSTDHPKYSDMIVAAIQAEKNRAGSSRQSIQKYIKSHYKVGENADSQIKLSIKRLVTTGVLKQTKGVGASGSFRLAKSDEPKKSVAFKKTKKEIKKVATPKKASKPKKAASKAPTKKPKATPVKKAKKKLAATPKKAKKPKTVKAKPVKASKPKKAKPVKPKAKSSAKRAGKKK", "header": "sp|P07305|H10_HUMAN", "source": "UniProt", "size": "194" } ], "type": "one-hop" }, { "question": "Can you provide the amino acid sequence of P09211?", "source": "P09211", "entities": { "protein": "P09211" }, "answer": [ { "answer": "MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGDLTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYVKALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAYVGRLSARPKLKAFLASPEYVNLPINGNGKQ", "header": "sp|P09211|GSTP1_HUMAN", "source": "UniProt", "size": "210" } ], "type": "one-hop" }, { "question": "Could you tell me the amino acid sequence of P0DN37?", "source": "P0DN37", "entities": { "protein": "P0DN37" }, "answer": [ { "answer": "MVNSVIFFDITVDGKPLGRISIKQFADKIPKTAENFRALSTGEKGFRYKGSCFHRIIPGFMCQGGDFTHPNGTGDKSIYGEKFDDENLIRKHTGSGILSMANAGPNTNGSQFFICTAKTEWLDGKHVAFGKVKERVNIVEAMEHFGYRNSKTSKKITIADCGQF", "header": "sp|P0DN37|PAL4G_HUMAN", "source": "UniProt", "size": "164" } ], "type": "one-hop" }, { "question": "Please identify the amino acid sequence of P12104.", "source": "P12104", "entities": { "protein": "P12104" }, "answer": [ { "answer": "MAFDSTWKVDRSENYDKFMEKMGVNIVKRKLAAHDNLKLTITQEGNKFTVKESSTFRNIEVVFELGVTFNYNLADGTELRGTWSLEGNKLIGKFKRTDNGNELNTVREIIGDELVQTYVYEGVEAKRIFKKD", "header": "sp|P12104|FABPI_HUMAN", "source": "UniProt", "size": "132" } ], "type": "one-hop" }, { "question": "Can you display the amino acid sequence that constitutes P17152?", "source": "P17152", "entities": { "protein": "P17152" }, "answer": [ { "answer": "MAAWGRRRLGPGSSGGSARERVSLSATDCYIVHEIYNGENAQDQFEYELEQALEAQYKYIVIEPTRIGDETARWITVGNCLHKTAVLAGTACLFTPLALPLDYSHYISLPAGVLSLACCTLYGISWQFDPCCKYQVEYDAYKLSRLPLHTLTSSTPVVLVRKDDLHRKRLHNTIALAALVYCVKKIYELYAV", "header": "sp|P17152|TMM11_HUMAN", "source": "UniProt", "size": "192" } ], "type": "one-hop" }, { "question": "What's the amino acid sequence of P48509?", "source": "P48509", "entities": { "protein": "P48509" }, "answer": [ { "answer": "MGEFNEKKTTCGTVCLKYLLFTYNCCFWLAGLAVMAVGIWTLALKSDYISLLASGTYLATAYILVVAGTVVMVTGVLGCCATFKERRNLLRLYFILLLIIFLLEIIAGILAYAYYQQLNTELKENLKDTMTKRYHQPGHEAVTSAVDQLQQEFHCCGSNNSQDWRDSEWIRSQEAGGRVVPDSCCKTVVALCGQRDHASNIYKVEGGCITKLETFIQEHLRVIGAVGIGIACVQVFGMIFTCCLYRSLKLEHY", "header": "sp|P48509|CD151_HUMAN", "source": "UniProt", "size": "253" } ], "type": "one-hop" }, { "question": "Can you provide the amino acid sequence of P59773?", "source": "P59773", "entities": { "protein": "P59773" }, "answer": [ { "answer": "MDLSVLPNNNHPDKFLQLDVKSLTRSSALLQASLVRFPGGNYPAAQHWQNLVYSQREKKNIAAQRIRGSSADSLVTADSPPPSMSSVMKNNPLYGDLSLEEAMEERKKNPSWTIEEYDKHSLHTNLSGHLKENPNDLRFWLGDMYTPGFDTLLKKEEKQEKHSKFCRMGLILLVVISILVTIVTIITFFT", "header": "sp|P59773|MNARL_HUMAN", "source": "UniProt", "size": "190" } ], "type": "one-hop" }, { "question": "Could you tell me the amino acid sequence of Q14582?", "source": "Q14582", "entities": { "protein": "Q14582" }, "answer": [ { "answer": "MELNSLLILLEAAEYLERRDREAEHGYASVLPFDGDFAREKTKAAGLVRKAPNNRSSHNELEKHRRAKLRLYLEQLKQLVPLGPDSTRHTTLSLLKRAKVHIKKLEEQDRRALSIKEQLQQEHRFLKRRLEQLSVQSVERVRTDSTGSAVSTDDSEQEVDIEGMEFGPGELDSVGSSSDADDHYSLQSGTGGDSGFGPHCRRLGRPALS", "header": "sp|Q14582|MAD4_HUMAN", "source": "UniProt", "size": "209" } ], "type": "one-hop" }, { "question": "Please identify the amino acid sequence of Q30KP8.", "source": "Q30KP8", "entities": { "protein": "Q30KP8" }, "answer": [ { "answer": "MNLCLSALLFFLVILLPSGKGMFGNDGVKVRTCTSQKAVCFFGCPPGYRWIAFCHNILSCCKNMTRFQPPQAKDPWVH", "header": "sp|Q30KP8|DB136_HUMAN", "source": "UniProt", "size": "78" } ], "type": "one-hop" }, { "question": "Can you display the amino acid sequence that constitutes Q6URK8?", "source": "Q6URK8", "entities": { "protein": "Q6URK8" }, "answer": [ { "answer": "MARIIDLVPWDDGSTHVYASPAILLPMERQRNQLAGVKQQLYHPALPTLRHMDRDTVKACLPDEHCQSTTYCRKDEFDNAHFTLLGVPNKPLQCLDITATGQKLRNRYHEGKLAPIAPGINRVDWPCFTRAIEDWSHFVSSAGEFKLPCLRKRAEGLSGYAVRYLKPDVTQTWRYCLSQNPSLDRYGQKPLPFDSLNTFRSFGSSYSRVNYLTPWH", "header": "sp|Q6URK8|SMIP8_HUMAN", "source": "UniProt", "size": "216" } ], "type": "one-hop" }, { "question": "What's the amino acid sequence of Q7Z4L0?", "source": "Q7Z4L0", "entities": { "protein": "Q7Z4L0" }, "answer": [ { "answer": "MPLLRGRCPARRHYRRLALLGLQPAPRFAHSGPPRQRPLSAAEMAVGLVVFFTTFLTPAAYVLGNLKQFRRN", "header": "sp|Q7Z4L0|COX8C_HUMAN", "source": "UniProt", "size": "72" } ], "type": "one-hop" }, { "question": "Can you provide the amino acid sequence of Q93096?", "source": "Q93096", "entities": { "protein": "Q93096" }, "answer": [ { "answer": "MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ", "header": "sp|Q93096|TP4A1_HUMAN", "source": "UniProt", "size": "173" } ], "type": "one-hop" }, { "question": "Could you tell me the amino acid sequence of Q96CP7?", "source": "Q96CP7", "entities": { "protein": "Q96CP7" }, "answer": [ { "answer": "MPRLLHPALPLLLGATLTFRALRRALCRLPLPVHVRADPLRTWRWHNLLVSFAHSIVSGIWALLCVWQTPDMLVEIETAWSLSGYLLVCFSAGYFIHDTVDIVASGQTRASWEYLVHHVMAMGAFFSGIFWSSFVGGGVLTLLVEVSNIFLTIRMMMKISNAQDHLLYRVNKYVNLVMYFLFRLAPQAYLTHFFLRYVNQRTLGTFLLGILLMLDVMIIIYFSRLLRSDFCPEHVPKKQHKDKFLTE", "header": "sp|Q96CP7|TLCD1_HUMAN", "source": "UniProt", "size": "247" } ], "type": "one-hop" }, { "question": "Please identify the amino acid sequence of Q96KF7.", "source": "Q96KF7", "entities": { "protein": "Q96KF7" }, "answer": [ { "answer": "MSSAPEPPTFKKEPPKEKEFQSPGLRGVRTTTLFRAVNPELFIKPNKPVMAFGLVTLSLCVAYIGYLHAIQENKKDLYEAIDSEGHSYMRRKTSKWD", "header": "sp|Q96KF7|SMIM8_HUMAN", "source": "UniProt", "size": "97" } ], "type": "one-hop" }, { "question": "Can you display the amino acid sequence that constitutes Q9UHF5?", "source": "Q9UHF5", "entities": { "protein": "Q9UHF5" }, "answer": [ { "answer": "MDWPHNLLFLLTISIFLGLGQPRSPKSKRKGQGRPGPLAPGPHQVPLDLVSRMKPYARMEEYERNIEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCLCLGCVNPFTMQEDRSMVSVPVFSQVPVRRRLCPPPPRTGPCRQRAVMETIAVGCTCIF", "header": "sp|Q9UHF5|IL17B_HUMAN", "source": "UniProt", "size": "180" } ], "type": "one-hop" }, { "question": "What's the amino acid sequence of Q9UMX6?", "source": "Q9UMX6", "entities": { "protein": "Q9UMX6" }, "answer": [ { "answer": "MGQEFSWEEAEAAGEIDVAELQEWYKKFVMECPSGTLFMHEFKRFFKVTDDEEASQYVEGMFRAFDKNGDNTIDFLEYVAALNLVLRGTLEHKLKWTFKIYDKDGNGCIDRLELLNIVEGIYQLKKACRRELQTEQGQLLTPEEVVDRIFLLVDENGDGQLSLNEFVEGARRDKWVMKMLQMDMNPSSWLAQQRRKSAMF", "header": "sp|Q9UMX6|GUC1B_HUMAN", "source": "UniProt", "size": "200" } ], "type": "one-hop" }, { "question": "Can you provide the amino acid sequence of A0A1W2PPE2?", "source": "A0A1W2PPE2", "entities": { "protein": "A0A1W2PPE2" }, "answer": [ { "answer": "METGRQTGVSAEMLAMPRGLKGSKKDGIPEDLDGNLEAPRDQEGELRSEDVMDLTEGDSEASASAPPAAKRRKTHTKGKKESKPTVDAEEAQRMTTLLSSMSEEQLSRYEVCRRSAFPRARVAGLMRAITGSSVSENAAIAMAGIAKLFVGEVVEEALDVCEMWGETPPLQPKHLREAVRRLKPKGLFPNSNCKRIMF", "header": "sp|A0A1W2PPE2|TFKL4_HUMAN", "source": "UniProt", "size": "198" } ], "type": "one-hop" }, { "question": "Could you tell me the amino acid sequence of A8MUL3?", "source": "A8MUL3", "entities": { "protein": "A8MUL3" }, "answer": [ { "answer": "MKQLFPPPPGTSLTHALGAWRGRERAQAATSLLASSASQFPTAVEDALMSVLTSHCAPSTPAATRAQQTGTRGHIHPACPCQQSCVGASRPPGRPQIFLPLTTALSLEAYAADTCSAADFLHNPSSWGKVWYLNEASFDLYSYHYFW", "header": "sp|A8MUL3|ADAS1_HUMAN", "source": "UniProt", "size": "147" } ], "type": "one-hop" }, { "question": "Please identify the amino acid sequence of O14817.", "source": "O14817", "entities": { "protein": "O14817" }, "answer": [ { "answer": "MARACLQAVKYLMFAFNLLFWLGGCGVLGVGIWLAATQGSFATLSSSFPSLSAANLLIITGAFVMAIGFVGCLGAIKENKCLLLTFFLLLLLVFLLEATIAILFFAYTDKIDRYAQQDLKKGLHLYGTQGNVGLTNAWSIIQTDFRCCGVSNYTDWFEVYNATRVPDSCCLEFSESCGLHAPGTWWKAPCYETVKVWLQENLLAVGIFGLCTALVQILGLTFAMTMYCQVVKADTYCA", "header": "sp|O14817|TSN4_HUMAN", "source": "UniProt", "size": "238" } ], "type": "one-hop" }, { "question": "Can you display the amino acid sequence that constitutes O43169?", "source": "O43169", "entities": { "protein": "O43169" }, "answer": [ { "answer": "MSGSMATAEASGSDGKGQEVETSVTYYRLEEVAKRNSLKELWLVIHGRVYDVTRFLNEHPGGEEVLLEQAGVDASESFEDVGHSSDAREMLKQYYIGDIHPSDLKPESGSKDPSKNDTCKSCWAYWILPIIGAVLLGFLYRYYTSESKSS", "header": "sp|O43169|CYB5B_HUMAN", "source": "UniProt", "size": "150" } ], "type": "one-hop" }, { "question": "What's the amino acid sequence of P05231?", "source": "P05231", "entities": { "protein": "P05231" }, "answer": [ { "answer": "MNSFSTSAFGPVAFSLGLLLVLPAAFPAPVPPGEDSKDVAAPHRQPLTSSERIDKQIRYILDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM", "header": "sp|P05231|IL6_HUMAN", "source": "UniProt", "size": "212" } ], "type": "one-hop" }, { "question": "Can you provide the amino acid sequence of P24390?", "source": "P24390", "entities": { "protein": "P24390" }, "answer": [ { "answer": "MNLFRFLGDLSHLLAIILLLLKIWKSRSCAGISGKSQVLFAVVFTARYLDLFTNYISLYNTCMKVVYIACSFTTVWLIYSKFKATYDGNHDTFRVEFLVVPTAILAFLVNHDFTPLEILWTFSIYLESVAILPQLFMVSKTGEAETITSHYLFALGVYRTLYLFNWIWRYHFEGFFDLIAIVAGLVQTVLYCDFFYLYITKVLKGKKLSLPA", "header": "sp|P24390|ERD21_HUMAN", "source": "UniProt", "size": "212" } ], "type": "one-hop" }, { "question": "Could you tell me the amino acid sequence of P56278?", "source": "P56278", "entities": { "protein": "P56278" }, "answer": [ { "answer": "MAGEDVGAPPDHLWVHQEGIYRDEYQRTWVAVVEEETSFLRARVQQIQVPLGDAARPSHLLTSQLPLMWQLYPEERYMDNNSRLWQIQHHLMVRGVQELLLKLLPDD", "header": "sp|P56278|MTCP1_HUMAN", "source": "UniProt", "size": "107" } ], "type": "one-hop" }, { "question": "Please identify the amino acid sequence of P61204.", "source": "P61204", "entities": { "protein": "P61204" }, "answer": [ { "answer": "MGNIFGNLLKSLIGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLANQLKNKK", "header": "sp|P61204|ARF3_HUMAN", "source": "UniProt", "size": "181" } ], "type": "one-hop" }, { "question": "Can you display the amino acid sequence that constitutes P86481?", "source": "P86481", "entities": { "protein": "P86481" }, "answer": [ { "answer": "MEEPRPSKRLRSMAPNQASGGPPPEPGCCVADPEGSVEADGPAQPAQPAKPIAYVKPFRRQPPARPESPPPAERGRRRGGSRRPGRGRGRRAGPRGDAGQRQGAEGLMAPDVHIQLDHHGEPGHQGEPEITETAAFSLSETGPPPGTVQEGPGPDVAQPELGFQEPPAAPGPQAVDWQPVLTLYPCIGFRALGDSAVLQVIQTPQGTYVQGVPVFLTDIAY", "header": "sp|P86481|PR20B_HUMAN", "source": "UniProt", "size": "221" } ], "type": "one-hop" }, { "question": "What's the amino acid sequence of Q06055?", "source": "Q06055", "entities": { "protein": "Q06055" }, "answer": [ { "answer": "MFACSKFVSTPSLVKSTSQLLSRPLSAVVLKRPEILTDESLSSLAVSCPLTSLVSSRSFQTSAISRDIDTAAKFIGAGAATVGVAGSGAGIGTVFGSLIIGYARNPSLKQQLFSYAILGFALSEAMGLFCLMVAFLILFAM", "header": "sp|Q06055|AT5G2_HUMAN", "source": "UniProt", "size": "141" } ], "type": "one-hop" }, { "question": "Can you provide the amino acid sequence of Q13242?", "source": "Q13242", "entities": { "protein": "Q13242" }, "answer": [ { "answer": "MSGWADERGGEGDGRIYVGNLPTDVREKDLEDLFYKYGRIREIELKNRHGLVPFAFVRFEDPRDAEDAIYGRNGYDYGQCRLRVEFPRTYGGRGGWPRGGRNGPPTRRSDFRVLVSGLPPSGSWQDLKDHMREAGDVCYADVQKDGVGMVEYLRKEDMEYALRKLDDTKFRSHEGETSYIRVYPERSTSYGYSRSRSGSRGRDSPYQSRGSPHYFSPFRPY", "header": "sp|Q13242|SRSF9_HUMAN", "source": "UniProt", "size": "221" } ], "type": "one-hop" }, { "question": "Could you tell me the amino acid sequence of Q3ZCU0?", "source": "Q3ZCU0", "entities": { "protein": "Q3ZCU0" }, "answer": [ { "answer": "MSDRYLEQRISIKFCVKLNKSASETHHLLKEAYGDEVMSRARVFDWHKRFKEGREDVRDDARSGRPVTHRTDDNIQKVKDLVCSNRQLTVRMMAEELNLDKETVRLILKENLNMRKISAKVISGVLKETEPHYVAQAGLELLVSRDPPTLASQSSGIISMSHHAKPKPGVQWCKFQSESTGRRARSADVQGQEKMDVTAQEARTNLPFYLFVLFRSSMNWMMSMHIREGCLFITRSTNSNANLFRKHPHRHTQK", "header": "sp|Q3ZCU0|GVQW3_HUMAN", "source": "UniProt", "size": "254" } ], "type": "one-hop" }, { "question": "Please identify the amino acid sequence of Q5T871.", "source": "Q5T871", "entities": { "protein": "Q5T871" }, "answer": [ { "answer": "MSSDDKSKSNDPKTEPKNCDPKCEQKCESKCQPSCLKKLLQRCFEKCPWEKCPAPPKCLPCPSQSPSSCPPQPCTKPCPPKCPSSCPHACPPPCPPPE", "header": "sp|Q5T871|LELP1_HUMAN", "source": "UniProt", "size": "98" } ], "type": "one-hop" }, { "question": "Can you display the amino acid sequence that constitutes Q6UXQ4?", "source": "Q6UXQ4", "entities": { "protein": "Q6UXQ4" }, "answer": [ { "answer": "MIIDSSRIPSFTQLHSTMTRAPLLLLCVALVLLGHVNGATVRNEDKWKPLNNPRNRDLFFRRLQAYFKGRGLDLGTFPNPFPTNENPRPLSFQSELTASASADYEEQKNSFHNYLKG", "header": "sp|Q6UXQ4|CB066_HUMAN", "source": "UniProt", "size": "117" } ], "type": "one-hop" }, { "question": "Which biological processes is the protein Q8NGI8 associated with?", "source": "Q8NGI8", "entities": { "protein": "Q8NGI8" }, "answer": [ { "answer": "detection of chemical stimulus involved in sensory perception of smell", "description": "The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal. [GOC:ai]" }, { "answer": "detection of chemical stimulus involved in sensory perception", "description": "The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception. [GOC:ai, GOC:dos]" }, { "answer": "G protein-coupled receptor signaling pathway", "description": "The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]" } ], "type": "one-hop" }, { "question": "What biological processes involve the protein Q9BXD5?", "source": "Q9BXD5", "entities": { "protein": "Q9BXD5" }, "answer": [ { "answer": "N-acetylneuraminate catabolic process", "description": "The chemical reactions and pathways resulting in the breakdown of N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid. [ISBN:0198506732]" }, { "answer": "carbohydrate metabolic process", "description": "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. [GOC:mah, ISBN:0198506732]" } ], "type": "one-hop" }, { "question": "Can you list the biological processes that the protein O95997 is associated with?", "source": "O95997", "entities": { "protein": "O95997" }, "answer": [ { "answer": "spermatogenesis", "description": "The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]" }, { "answer": "DNA repair", "description": "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. [PMID:11563486]" }, { "answer": "chromosome organization", "description": "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome. [GOC:ai, GOC:dph, GOC:jl, GOC:mah]" }, { "answer": "cell division", "description": "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. [GOC:di, GOC:go_curators, GOC:pr]" }, { "answer": "homologous chromosome segregation", "description": "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets. [GOC:ai, ISBN:0815316194]" } ], "type": "one-hop" }, { "question": "Could you identify which biological processes is the protein O95977 associated with?", "source": "O95977", "entities": { "protein": "O95977" }, "answer": [ { "answer": "regulation of metabolic process", "description": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. [GOC:go_curators]" }, { "answer": "adenylate cyclase-activating G protein-coupled receptor signaling pathway", "description": "A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]" }, { "answer": "sphingosine-1-phosphate receptor signaling pathway", "description": "A G protein-coupled receptor signaling pathway initiated by sphingosine-1-phosphate binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ascb_2009, GOC:signaling, PMID:14592418, PMID:22001186, Reactome:R-HSA-419428]" }, { "answer": "G protein-coupled receptor signaling pathway", "description": "The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]" }, { "answer": "activation of phospholipase C activity", "description": "The initiation of the activity of the inactive enzyme phospolipase C as the result of The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand. [GOC:dph, GOC:mah, GOC:tb, PMID:8280098]" }, { "answer": "positive regulation of cytosolic calcium ion concentration", "description": "Any process that increases the concentration of calcium ions in the cytosol. [GOC:ai]" }, { "answer": "immune response", "description": "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. [GO_REF:0000022, GOC:add]" } ], "type": "one-hop" }, { "question": "I'm curious, biological processes is the protein P54107 associated with?", "source": "P54107", "entities": { "protein": "P54107" }, "answer": [ { "answer": "binding of sperm to zona pellucida", "description": "The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place. [GOC:dph, ISBN:0878932437]" }, { "answer": "fusion of sperm to egg plasma membrane involved in single fertilization", "description": "The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of single fertilization. In sperm with flagella, binding occurs at the posterior (post-acrosomal) region of the sperm head. [GOC:dph, GOC:jl, http://arbl.cvmbs.colostate.edu/hbooks/pathphys/reprod/fert/fert.html]" }, { "answer": "regulation of acrosome reaction", "description": "Any process that modulates the frequency, rate or extent of the acrosome reaction. [GOC:dph]" } ], "type": "one-hop" }, { "question": "Which biological processes is the protein Q13609 associated with?", "source": "Q13609", "entities": { "protein": "Q13609" }, "answer": [ { "answer": "regulation of acute inflammatory response", "description": "Any process that modulates the frequency, rate, or extent of an acute inflammatory response. [GOC:add]" }, { "answer": "apoptotic DNA fragmentation", "description": "The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments. [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976, PMID:15723341, PMID:23379520]" }, { "answer": "programmed cell death involved in cell development", "description": "The activation of endogenous cellular processes that result in the death of a cell as part of its development. [GOC:dph, GOC:mtg_apoptosis, GOC:tb]" }, { "answer": "neutrophil activation involved in immune response", "description": "The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. [GOC:add, ISBN:0781735149]" }, { "answer": "regulation of neutrophil mediated cytotoxicity", "description": "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a target cell, the directed killing of a target cell by a neutrophil. [GOC:add, GOC:mah]" }, { "answer": "DNA metabolic process", "description": "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. [ISBN:0198506732]" } ], "type": "one-hop" }, { "question": "What biological processes involve the protein Q8WWV3?", "source": "Q8WWV3", "entities": { "protein": "Q8WWV3" }, "answer": [ { "answer": "regulation of dendrite development", "description": "Any process that modulates the frequency, rate or extent of dendrite development. [GOC:ai]" }, { "answer": "nervous system development", "description": "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. [GOC:dgh]" } ], "type": "one-hop" }, { "question": "Can you list the biological processes that the protein Q9NVA4 is associated with?", "source": "Q9NVA4", "entities": { "protein": "Q9NVA4" }, "answer": [ { "answer": "transport", "description": "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein. [GOC:dos, GOC:dph, GOC:jl, GOC:mah]" } ], "type": "one-hop" }, { "question": "Could you identify which biological processes is the protein Q9NS39 associated with?", "source": "Q9NS39", "entities": { "protein": "Q9NS39" }, "answer": [ { "answer": "adenosine to inosine editing", "description": "The conversion of an adenosine residue to inosine in an RNA molecule by deamination. [PMID:11092837]" }, { "answer": "mRNA processing", "description": "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. [GOC:mah]" }, { "answer": "RNA processing", "description": "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. [GOC:mah]" } ], "type": "one-hop" }, { "question": "I'm curious, biological processes is the protein Q9BRS2 associated with?", "source": "Q9BRS2", "entities": { "protein": "Q9BRS2" }, "answer": [ { "answer": "maturation of SSU-rRNA", "description": "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule. [GOC:curators]" }, { "answer": "phosphorylation", "description": "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. [ISBN:0198506732]" }, { "answer": "positive regulation of rRNA processing", "description": "Any process that activates or increases the frequency, rate or extent of rRNA processing. [GOC:mah]" }, { "answer": "ribosomal small subunit biogenesis", "description": "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis. [GOC:jl]" } ], "type": "one-hop" }, { "question": "Which biological processes is the protein Q96G21 associated with?", "source": "Q96G21", "entities": { "protein": "Q96G21" }, "answer": [ { "answer": "maturation of SSU-rRNA", "description": "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule. [GOC:curators]" }, { "answer": "rRNA processing", "description": "Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. [GOC:curators]" }, { "answer": "ribosomal small subunit biogenesis", "description": "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis. [GOC:jl]" } ], "type": "one-hop" }, { "question": "What biological processes involve the protein P35573?", "source": "P35573", "entities": { "protein": "P35573" }, "answer": [ { "answer": "response to glucocorticoid", "description": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. [GOC:ai, PMID:9884123]" }, { "answer": "glycogen biosynthetic process", "description": "The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. [ISBN:0198506732]" }, { "answer": "glycogen catabolic process", "description": "The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. [ISBN:0198506732]" }, { "answer": "response to nutrient", "description": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus. [GOC:go_curators]" } ], "type": "one-hop" }, { "question": "Can you list the biological processes that the protein P56747 is associated with?", "source": "P56747", "entities": { "protein": "P56747" }, "answer": [ { "answer": "symbiont entry into host cell", "description": "The process by which a symbiont breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the symbiont or its genome is released into the host cell. [GOC:jl]" }, { "answer": "bicellular tight junction assembly", "description": "The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet. [GOC:mah]" }, { "answer": "cell adhesion", "description": "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. [GOC:hb, GOC:pf]" }, { "answer": "calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules", "description": "The attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction. [GOC:hb]" } ], "type": "one-hop" }, { "question": "Could you identify which biological processes is the protein O95674 associated with?", "source": "O95674", "entities": { "protein": "O95674" }, "answer": [ { "answer": "CDP-diacylglycerol biosynthetic process", "description": "The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. [PMID:24533860]" }, { "answer": "lipid droplet formation", "description": "A process that results in the assembly, arrangement of constituent parts of a lipid droplet. [PMID:28011631]" }, { "answer": "phosphatidylglycerol biosynthetic process", "description": "The chemical reactions and pathways resulting in the formation of phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. [ISBN:0198506732]" } ], "type": "one-hop" }, { "question": "I'm curious, biological processes is the protein P53675 associated with?", "source": "P53675", "entities": { "protein": "P53675" }, "answer": [ { "answer": "receptor-mediated endocytosis", "description": "An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles. [GOC:mah, ISBN:0716731363]" }, { "answer": "anatomical structure morphogenesis", "description": "The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form. [GOC:go_curators, ISBN:0521436125]" }, { "answer": "positive regulation of glucose import", "description": "Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle. [GOC:ai, GOC:dph, GOC:tb]" }, { "answer": "retrograde transport, endosome to Golgi", "description": "The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport. [GOC:jl, PMID:10873832, PMID:16936697]" }, { "answer": "mitotic cell cycle", "description": "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. [GOC:mah, ISBN:0815316194, Reactome:69278]" }, { "answer": "intracellular protein transport", "description": "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. [GOC:mah]" } ], "type": "one-hop" }, { "question": "Which biological processes is the protein O75031 associated with?", "source": "O75031", "entities": { "protein": "O75031" }, "answer": [ { "answer": "double-strand break repair involved in meiotic recombination", "description": "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix that contributes to reciprocal meiotic recombination. [GOC:mah, PMID:15238514]" }, { "answer": "female meiosis I", "description": "The cell cycle process in which the first meiotic division occurs in the female germline. [GOC:mah]" }, { "answer": "spermatogenesis", "description": "The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]" }, { "answer": "transcription by RNA polymerase II", "description": "The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). [GOC:jl, GOC:txnOH, ISBN:0321000382]" }, { "answer": "male meiosis I", "description": "A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline. [GOC:dph, GOC:mah]" } ], "type": "one-hop" }, { "question": "What biological processes involve the protein Q8N4L2?", "source": "Q8N4L2", "entities": { "protein": "Q8N4L2" }, "answer": [ { "answer": "negative regulation of phagocytosis", "description": "Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis. [GOC:ai]" }, { "answer": "phosphatidylinositol dephosphorylation", "description": "The process of removing one or more phosphate groups from a phosphatidylinositol. [ISBN:0198506732]" } ], "type": "one-hop" }, { "question": "Can you list the biological processes that the protein A0A0A6YYD4 is associated with?", "source": "A0A0A6YYD4", "entities": { "protein": "A0A0A6YYD4" }, "answer": [ { "answer": "cell surface receptor signaling pathway", "description": "The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription. [GOC:signaling]" }, { "answer": "adaptive immune response", "description": "An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory). [GO_REF:0000022, GOC:add, ISBN:0781735149]" } ], "type": "one-hop" }, { "question": "Could you identify which biological processes is the protein Q05048 associated with?", "source": "Q05048", "entities": { "protein": "Q05048" }, "answer": [ { "answer": "mRNA 3'-end processing", "description": "Any process involved in forming the mature 3' end of an mRNA molecule. [GOC:mah]" } ], "type": "one-hop" }, { "question": "I'm curious, biological processes is the protein Q99909 associated with?", "source": "Q99909", "entities": { "protein": "Q99909" }, "answer": [ { "answer": "regulation of DNA-templated transcription", "description": "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]" } ], "type": "one-hop" }, { "question": "Which biological processes is the protein A6NH21 associated with?", "source": "A6NH21", "entities": { "protein": "A6NH21" }, "answer": [ { "answer": "phospholipid biosynthetic process", "description": "The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester. [ISBN:0198506732]" } ], "type": "one-hop" }, { "question": "What biological processes involve the protein Q8N8G2?", "source": "Q8N8G2", "entities": { "protein": "Q8N8G2" }, "answer": [ { "answer": "regulation of transcription by RNA polymerase II", "description": "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]" }, { "answer": "skeletal muscle tissue development", "description": "The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers. [GOC:mtg_muscle]" }, { "answer": "positive regulation of transcription by RNA polymerase II", "description": "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]" } ], "type": "one-hop" }, { "question": "Can you list the biological processes that the protein A0A0A6YYK7 is associated with?", "source": "A0A0A6YYK7", "entities": { "protein": "A0A0A6YYK7" }, "answer": [ { "answer": "immunoglobulin production", "description": "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:add, ISBN:0781735149]" }, { "answer": "immune response", "description": "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. [GO_REF:0000022, GOC:add]" }, { "answer": "adaptive immune response", "description": "An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory). [GO_REF:0000022, GOC:add, ISBN:0781735149]" } ], "type": "one-hop" }, { "question": "Could you identify which biological processes is the protein Q16533 associated with?", "source": "Q16533", "entities": { "protein": "Q16533" }, "answer": [ { "answer": "snRNA transcription by RNA polymerase II", "description": "The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter. [GOC:jl, ISBN:0321000382]" }, { "answer": "snRNA transcription by RNA polymerase III", "description": "The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter. [GOC:jl, ISBN:0321000382]" } ], "type": "one-hop" }, { "question": "I'm curious, biological processes is the protein Q9BXJ9 associated with?", "source": "Q9BXJ9", "entities": { "protein": "Q9BXJ9" }, "answer": [ { "answer": "negative regulation of apoptotic process", "description": "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]" }, { "answer": "N-terminal peptidyl-methionine acetylation", "description": "The acetylation of the N-terminal methionine of proteins to form the derivative N-acetyl-L-methionine. [RESID:AA0049]" }, { "answer": "cell differentiation", "description": "The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. [ISBN:0198506732]" }, { "answer": "N-terminal protein amino acid acetylation", "description": "The acetylation of the N-terminal amino acid of proteins. [GOC:ai]" }, { "answer": "protein stabilization", "description": "Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. [GOC:ai]" }, { "answer": "angiogenesis", "description": "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. [ISBN:0878932453]" }, { "answer": "positive regulation of DNA-templated transcription", "description": "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]" } ], "type": "one-hop" }, { "question": "Which biological processes is the protein Q70JA7 associated with?", "source": "Q70JA7", "entities": { "protein": "Q70JA7" }, "answer": [ { "answer": "chondroitin sulfate biosynthetic process", "description": "The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. [GOC:mah, ISBN:0198506732]" } ], "type": "one-hop" }, { "question": "What biological processes involve the protein Q9NUJ7?", "source": "Q9NUJ7", "entities": { "protein": "Q9NUJ7" }, "answer": [ { "answer": "lipid metabolic process", "description": "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. [GOC:ma]" } ], "type": "one-hop" }, { "question": "Can you list the biological processes that the protein Q5SZJ8 is associated with?", "source": "Q5SZJ8", "entities": { "protein": "Q5SZJ8" }, "answer": [ { "answer": "positive regulation of neuron differentiation", "description": "Any process that activates or increases the frequency, rate or extent of neuron differentiation. [GOC:go_curators]" }, { "answer": "negative regulation of DNA-templated transcription", "description": "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]" }, { "answer": "negative regulation of Notch signaling pathway", "description": "Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway. [GOC:go_curators]" }, { "answer": "nervous system development", "description": "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. [GOC:dgh]" } ], "type": "one-hop" }, { "question": "Could you identify which biological processes is the protein Q14676 associated with?", "source": "Q14676", "entities": { "protein": "Q14676" }, "answer": [ { "answer": "protein localization to site of double-strand break", "description": "Any process in which a protein is transported to, or maintained at, a region of a chromosome at which a DNA double-strand break has occurred. [GOC:mah, PMID:23080121]" }, { "answer": "DNA repair", "description": "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. [PMID:11563486]" }, { "answer": "mitotic intra-S DNA damage checkpoint signaling", "description": "A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression. [GOC:vw]" }, { "answer": "positive regulation of transcription initiation by RNA polymerase II", "description": "Any process that increases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter. [GOC:dph, GOC:tb, GOC:txnOH]" }, { "answer": "chromatin organization", "description": "The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. [PMID:20404130]" }, { "answer": "DNA damage response", "description": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. [GOC:go_curators]" }, { "answer": "DNA replication checkpoint signaling", "description": "A signal transduction process that contributes to a DNA replication checkpoint, that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome. [GOC:curators, GOC:rn, PMID:11728327, PMID:12537518]" } ], "type": "one-hop" }, { "question": "I'm curious, biological processes is the protein Q86U17 associated with?", "source": "Q86U17", "entities": { "protein": "Q86U17" }, "answer": [ { "answer": "negative regulation of endopeptidase activity", "description": "Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins. [GOC:dph, GOC:tb]" } ], "type": "one-hop" }, { "question": "Which biological processes is the protein Q68DX3 associated with?", "source": "Q68DX3", "entities": { "protein": "Q68DX3" }, "answer": [ { "answer": "bicellular tight junction assembly", "description": "The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet. [GOC:mah]" } ], "type": "one-hop" }, { "question": "What biological processes involve the protein O43826?", "source": "O43826", "entities": { "protein": "O43826" }, "answer": [ { "answer": "gluconeogenesis", "description": "The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. [MetaCyc:GLUCONEO-PWY]" }, { "answer": "phosphate ion transmembrane transport", "description": "The process in which a phosphate is transported across a membrane. [GOC:vw]" }, { "answer": "glucose-6-phosphate transport", "description": "The directed movement of glucose-6-phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6. [GOC:ai]" }, { "answer": "glucose metabolic process", "description": "The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. [ISBN:0198506732]" }, { "answer": "carbohydrate transport", "description": "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. [GOC:ai]" } ], "type": "one-hop" }, { "question": "Can you list the biological processes that the protein Q8N9K5 is associated with?", "source": "Q8N9K5", "entities": { "protein": "Q8N9K5" }, "answer": [ { "answer": "regulation of transcription by RNA polymerase II", "description": "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]" } ], "type": "one-hop" }, { "question": "Could you identify which biological processes is the protein O00170 associated with?", "source": "O00170", "entities": { "protein": "O00170" }, "answer": [ { "answer": "xenobiotic metabolic process", "description": "The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc]" }, { "answer": "protein maturation by protein folding", "description": "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that results in the attainment of the full functional capacity of a protein. [GOC:isa_complete]" }, { "answer": "positive regulation of DNA-templated transcription", "description": "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]" }, { "answer": "protein targeting to mitochondrion", "description": "The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein. [GOC:mcc, ISBN:0716731363]" }, { "answer": "regulation of protein kinase A signaling", "description": "Any process that modulates the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound. [GOC:BHF, GOC:dph, GOC:tb]" } ], "type": "one-hop" }, { "question": "I'm curious, biological processes is the protein Q8N0T1 associated with?", "source": "Q8N0T1", "entities": { "protein": "Q8N0T1" }, "answer": [ { "answer": "ribosome biogenesis", "description": "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis. [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]" } ], "type": "one-hop" }, { "question": "Which biological processes is the protein Q13361 associated with?", "source": "Q13361", "entities": { "protein": "Q13361" }, "answer": [ { "answer": "definitive hemopoiesis", "description": "A second wave of blood cell production that, in vertebrates, generates long-term hemopoietic stem cells that continously provide erythroid, myeloid and lymphoid lineages throughout adulthood. [GOC:bf, GOC:dph, PMID:15378083, PMID:15617691]" }, { "answer": "supramolecular fiber organization", "description": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. [GOC:pr]" }, { "answer": "embryonic eye morphogenesis", "description": "The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized. [GOC:jid]" } ], "type": "one-hop" }, { "question": "What biological processes involve the protein Q9UHY7?", "source": "Q9UHY7", "entities": { "protein": "Q9UHY7" }, "answer": [ { "answer": "L-methionine salvage from methylthioadenosine", "description": "The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine. [GOC:jl, MetaCyc:PWY-4361]" }, { "answer": "L-methionine salvage from S-adenosylmethionine", "description": "The chemical reactions and pathways resulting in the formation of L-methionine from S-adenosylmethionine. [GOC:go_curators, GOC:vw]" } ], "type": "one-hop" }, { "question": "Can you list the biological processes that the protein Q8NHG8 is associated with?", "source": "Q8NHG8", "entities": { "protein": "Q8NHG8" }, "answer": [ { "answer": "protein K48-linked ubiquitination", "description": "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation. [GOC:cvs, PMID:15556404]" }, { "answer": "proteasome-mediated ubiquitin-dependent protein catabolic process", "description": "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. [GOC:go_curators]" } ], "type": "one-hop" }, { "question": "Could you identify which biological processes is the protein Q8NGM9 associated with?", "source": "Q8NGM9", "entities": { "protein": "Q8NGM9" }, "answer": [ { "answer": "detection of chemical stimulus involved in sensory perception of smell", "description": "The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal. [GOC:ai]" }, { "answer": "G protein-coupled receptor signaling pathway", "description": "The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]" }, { "answer": "sensory perception of smell", "description": "The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process. [GOC:ai]" } ], "type": "one-hop" }, { "question": "I'm curious, biological processes is the protein Q14651 associated with?", "source": "Q14651", "entities": { "protein": "Q14651" }, "answer": [ { "answer": "actin filament bundle assembly", "description": "The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. [GOC:ai]" }, { "answer": "regulation of microvillus length", "description": "A process that modulates the length of a microvillus. [GOC:mah]" }, { "answer": "intestinal D-glucose absorption", "description": "Uptake of D-glucose into the blood by absorption from the small intestine. [GOC:mgi_curators, PMID:5601832]" }, { "answer": "positive regulation of multicellular organism growth", "description": "Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size. [GOC:dph, GOC:go_curators, GOC:tb]" }, { "answer": "positive regulation of protein localization to plasma membrane", "description": "Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]" }, { "answer": "auditory receptor cell stereocilium organization", "description": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of auditory hair cells. [GOC:dph, PMID:10978835]" }, { "answer": "actin filament network formation", "description": "The assembly of a network of actin filaments; actin filaments on different axes and with differing orientations are crosslinked together to form a mesh of filaments. [GOC:ai]" }, { "answer": "terminal web assembly", "description": "The aggregation, arrangement and bonding together of a set of components to form a terminal web. [GO_REF:0000079, GOC:kmv, GOC:TermGenie, PMID:21949650]" }, { "answer": "vestibular receptor cell stereocilium organization", "description": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of vestibular hair cells. [GOC:dph]" } ], "type": "one-hop" }, { "question": "In which pathways is the protein Q9H4I9 annotated?", "source": "Q9H4I9", "entities": { "protein": "Q9H4I9" }, "answer": [ { "answer": "Mitochondrial protein degradation", "description": "Mitochondrial protein degradation", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-9837999", "source": "Reactome" }, { "answer": "Processing of SMDT1", "description": "Processing of SMDT1", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-8949664", "source": "Reactome" }, { "answer": "Mitochondrial calcium ion transport", "description": "Mitochondrial calcium ion transport", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-8949215", "source": "Reactome" } ], "type": "one-hop" }, { "question": "Can you identify the pathways where the protein Q5JRA6 is annotated?", "source": "Q5JRA6", "entities": { "protein": "Q5JRA6" }, "answer": [ { "answer": "Post-translational protein phosphorylation", "description": "Post-translational protein phosphorylation", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-8957275", "source": "Reactome" }, { "answer": "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "description": "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-381426", "source": "Reactome" }, { "answer": "Cargo concentration in the ER", "description": "Cargo concentration in the ER", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-5694530", "source": "Reactome" } ], "type": "one-hop" }, { "question": "In what pathways has the protein Q9UP38 been annotated?", "source": "Q9UP38", "entities": { "protein": "Q9UP38" }, "answer": [ { "answer": "Class B/2 (Secretin family receptors)", "description": "Class B/2 (Secretin family receptors)", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-373080", "source": "Reactome" }, { "answer": "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "description": "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-4641262", "source": "Reactome" }, { "answer": "Asymmetric localization of PCP proteins", "description": "Asymmetric localization of PCP proteins", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-4608870", "source": "Reactome" }, { "answer": "PCP/CE pathway", "description": "PCP/CE pathway", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-4086400", "source": "Reactome" }, { "answer": "TCF dependent signaling in response to WNT", "description": "TCF dependent signaling in response to WNT", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-201681", "source": "Reactome" } ], "type": "one-hop" }, { "question": "Could you please specify the pathways in which the protein Q93063 is annotated?", "source": "Q93063", "entities": { "protein": "Q93063" }, "answer": [ { "answer": "Defective EXT2 causes exostoses 2", "description": "Defective EXT2 causes exostoses 2", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-3656237", "source": "Reactome" }, { "answer": "HS-GAG biosynthesis", "description": "HS-GAG biosynthesis", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-2022928", "source": "Reactome" }, { "answer": "Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "description": "Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-3656253", "source": "Reactome" } ], "type": "one-hop" }, { "question": "What pathways include the protein Q71SY5?", "source": "Q71SY5", "entities": { "protein": "Q71SY5" }, "answer": [ { "answer": "RSV-host interactions", "description": "RSV-host interactions", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-9833110", "source": "Reactome" }, { "answer": "Transcriptional regulation of white adipocyte differentiation", "description": "Transcriptional regulation of white adipocyte differentiation", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-381340", "source": "Reactome" }, { "answer": "PPARA activates gene expression", "description": "PPARA activates gene expression", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-1989781", "source": "Reactome" }, { "answer": "Generic Transcription Pathway", "description": "Generic Transcription Pathway", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-212436", "source": "Reactome" } ], "type": "one-hop" }, { "question": "In which pathways is the protein Q5T8I9 annotated?", "source": "Q5T8I9", "entities": { "protein": "Q5T8I9" }, "answer": [ { "answer": "PIWI-interacting RNA (piRNA) biogenesis", "description": "PIWI-interacting RNA (piRNA) biogenesis", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-5601884", "source": "Reactome" } ], "type": "one-hop" }, { "question": "Can you identify the pathways where the protein P13224 is annotated?", "source": "P13224", "entities": { "protein": "P13224" }, "answer": [ { "answer": "Enhanced binding of GP1BA variant to VWF multimer:collagen ", "description": "Enhanced binding of GP1BA variant to VWF multimer:collagen ", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-9845620", "source": "Reactome" }, { "answer": "Defective binding of VWF variant to GPIb:IX:V", "description": "Defective binding of VWF variant to GPIb:IX:V", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-9846298", "source": "Reactome" }, { "answer": "Platelet Adhesion to exposed collagen", "description": "Platelet Adhesion to exposed collagen", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-75892", "source": "Reactome" }, { "answer": "GP1b-IX-V activation signalling", "description": "GP1b-IX-V activation signalling", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-430116", "source": "Reactome" }, { "answer": "Defective F9 activation", "description": "Defective F9 activation", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-9673221", "source": "Reactome" }, { "answer": "Intrinsic Pathway of Fibrin Clot Formation", "description": "Intrinsic Pathway of Fibrin Clot Formation", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-140837", "source": "Reactome" }, { "answer": "Platelet Aggregation (Plug Formation)", "description": "Platelet Aggregation (Plug Formation)", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-76009", "source": "Reactome" } ], "type": "one-hop" }, { "question": "In what pathways has the protein Q9P0G3 been annotated?", "source": "Q9P0G3", "entities": { "protein": "Q9P0G3" }, "answer": [ { "answer": "Formation of the cornified envelope", "description": "Formation of the cornified envelope", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-6809371", "source": "Reactome" } ], "type": "one-hop" }, { "question": "Could you please specify the pathways in which the protein Q6UXL0 is annotated?", "source": "Q6UXL0", "entities": { "protein": "Q6UXL0" }, "answer": [ { "answer": "Interleukin-20 family signaling", "description": "Interleukin-20 family signaling", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-8854691", "source": "Reactome" } ], "type": "one-hop" }, { "question": "What pathways include the protein Q8TB69?", "source": "Q8TB69", "entities": { "protein": "Q8TB69" }, "answer": [ { "answer": "Generic Transcription Pathway", "description": "Generic Transcription Pathway", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-212436", "source": "Reactome" } ], "type": "one-hop" }, { "question": "In which pathways is the protein Q9NYM9 annotated?", "source": "Q9NYM9", "entities": { "protein": "Q9NYM9" }, "answer": [ { "answer": "COPI-mediated anterograde transport", "description": "COPI-mediated anterograde transport", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-6807878", "source": "Reactome" }, { "answer": "Intra-Golgi traffic", "description": "Intra-Golgi traffic", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-6811438", "source": "Reactome" } ], "type": "one-hop" }, { "question": "Can you identify the pathways where the protein Q12904 is annotated?", "source": "Q12904", "entities": { "protein": "Q12904" }, "answer": [ { "answer": "Selenoamino acid metabolism", "description": "Selenoamino acid metabolism", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-2408522", "source": "Reactome" }, { "answer": "Transcriptional and post-translational regulation of MITF-M expression and activity", "description": "Transcriptional and post-translational regulation of MITF-M expression and activity", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-9856649", "source": "Reactome" }, { "answer": "Cytosolic tRNA aminoacylation", "description": "Cytosolic tRNA aminoacylation", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-379716", "source": "Reactome" } ], "type": "one-hop" }, { "question": "In what pathways has the protein P51788 been annotated?", "source": "P51788", "entities": { "protein": "P51788" }, "answer": [ { "answer": "Stimuli-sensing channels", "description": "Stimuli-sensing channels", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-2672351", "source": "Reactome" } ], "type": "one-hop" }, { "question": "Could you please specify the pathways in which the protein P61073 is annotated?", "source": "P61073", "entities": { "protein": "P61073" }, "answer": [ { "answer": "Specification of primordial germ cells", "description": "Specification of primordial germ cells", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-9827857", "source": "Reactome" }, { "answer": "Formation of definitive endoderm", "description": "Formation of definitive endoderm", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-9823730", "source": "Reactome" }, { "answer": "CXCR4 Signaling Pathway", "description": "Protein", "linkout": "http://smpdb.ca/view/SMP0064625", "source": "SMPDB" }, { "answer": "G alpha (i) signalling events", "description": "G alpha (i) signalling events", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-418594", "source": "Reactome" }, { "answer": "Signaling by ROBO receptors", "description": "Signaling by ROBO receptors", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-376176", "source": "Reactome" }, { "answer": "Chemokine receptors bind chemokines", "description": "Chemokine receptors bind chemokines", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-380108", "source": "Reactome" }, { "answer": "Binding and entry of HIV virion", "description": "Binding and entry of HIV virion", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-173107", "source": "Reactome" } ], "type": "one-hop" }, { "question": "What pathways include the protein Q8TDD2?", "source": "Q8TDD2", "entities": { "protein": "Q8TDD2" }, "answer": [ { "answer": "RUNX2 regulates osteoblast differentiation", "description": "RUNX2 regulates osteoblast differentiation", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-8940973", "source": "Reactome" } ], "type": "one-hop" }, { "question": "In which pathways is the protein Q9BYE4 annotated?", "source": "Q9BYE4", "entities": { "protein": "Q9BYE4" }, "answer": [ { "answer": "Formation of the cornified envelope", "description": "Formation of the cornified envelope", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-6809371", "source": "Reactome" } ], "type": "one-hop" }, { "question": "Can you identify the pathways where the protein P61204 is annotated?", "source": "P61204", "entities": { "protein": "P61204" }, "answer": [ { "answer": "COPI-dependent Golgi-to-ER retrograde traffic", "description": "COPI-dependent Golgi-to-ER retrograde traffic", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-6811434", "source": "Reactome" }, { "answer": "Synthesis of PIPs at the Golgi membrane", "description": "Synthesis of PIPs at the Golgi membrane", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-1660514", "source": "Reactome" }, { "answer": "COPI-mediated anterograde transport", "description": "COPI-mediated anterograde transport", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-6807878", "source": "Reactome" } ], "type": "one-hop" }, { "question": "In what pathways has the protein Q8TAV4 been annotated?", "source": "Q8TAV4", "entities": { "protein": "Q8TAV4" }, "answer": [ { "answer": "Stimuli-sensing channels", "description": "Stimuli-sensing channels", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-2672351", "source": "Reactome" } ], "type": "one-hop" }, { "question": "Could you please specify the pathways in which the protein Q9UNL4 is annotated?", "source": "Q9UNL4", "entities": { "protein": "Q9UNL4" }, "answer": [ { "answer": "HATs acetylate histones", "description": "HATs acetylate histones", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-3214847", "source": "Reactome" } ], "type": "one-hop" }, { "question": "What pathways include the protein P08294?", "source": "P08294", "entities": { "protein": "P08294" }, "answer": [ { "answer": "NFE2L2 regulating anti-oxidant/detoxification enzymes", "description": "NFE2L2 regulating anti-oxidant/detoxification enzymes", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-9818027", "source": "Reactome" }, { "answer": "Degradation of Superoxides", "description": "Metabolic", "linkout": "http://smpdb.ca/view/SMP0000468", "source": "SMPDB" }, { "answer": "Detoxification of Reactive Oxygen Species", "description": "Detoxification of Reactive Oxygen Species", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-3299685", "source": "Reactome" } ], "type": "one-hop" }, { "question": "In which pathways is the protein Q14142 annotated?", "source": "Q14142", "entities": { "protein": "Q14142" }, "answer": [ { "answer": "Interferon gamma signaling", "description": "Interferon gamma signaling", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-877300", "source": "Reactome" } ], "type": "one-hop" }, { "question": "Can you identify the pathways where the protein P28562 is annotated?", "source": "P28562", "entities": { "protein": "P28562" }, "answer": [ { "answer": "CD40L Signalling Pathway", "description": "Protein", "linkout": "http://smpdb.ca/view/SMP0089759", "source": "SMPDB" }, { "answer": "RAF-independent MAPK1/3 activation", "description": "RAF-independent MAPK1/3 activation", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-112409", "source": "Reactome" }, { "answer": "Negative regulation of MAPK pathway", "description": "Negative regulation of MAPK pathway", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-5675221", "source": "Reactome" } ], "type": "one-hop" }, { "question": "In what pathways has the protein Q9ULC3 been annotated?", "source": "Q9ULC3", "entities": { "protein": "Q9ULC3" }, "answer": [ { "answer": "RAB geranylgeranylation", "description": "RAB geranylgeranylation", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-8873719", "source": "Reactome" } ], "type": "one-hop" }, { "question": "Could you please specify the pathways in which the protein O00631 is annotated?", "source": "O00631", "entities": { "protein": "O00631" }, "answer": [ { "answer": "Ion homeostasis", "description": "Ion homeostasis", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-5578775", "source": "Reactome" }, { "answer": "Ion transport by P-type ATPases", "description": "Ion transport by P-type ATPases", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-936837", "source": "Reactome" } ], "type": "one-hop" }, { "question": "What pathways include the protein Q9UHC7?", "source": "Q9UHC7", "entities": { "protein": "Q9UHC7" }, "answer": [ { "answer": "AKT phosphorylates targets in the cytosol", "description": "AKT phosphorylates targets in the cytosol", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-198323", "source": "Reactome" }, { "answer": "Regulation of PTEN stability and activity", "description": "Regulation of PTEN stability and activity", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-8948751", "source": "Reactome" }, { "answer": "Antigen processing: Ubiquitination & Proteasome degradation", "description": "Antigen processing: Ubiquitination & Proteasome degradation", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-983168", "source": "Reactome" } ], "type": "one-hop" }, { "question": "In which pathways is the protein Q8IUF8 annotated?", "source": "Q8IUF8", "entities": { "protein": "Q8IUF8" }, "answer": [ { "answer": "Protein hydroxylation", "description": "Protein hydroxylation", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-9629569", "source": "Reactome" }, { "answer": "HDMs demethylate histones", "description": "HDMs demethylate histones", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-3214842", "source": "Reactome" } ], "type": "one-hop" }, { "question": "Can you identify the pathways where the protein Q8TED4-2 is annotated?", "source": "Q8TED4-2", "entities": { "protein": "Q8TED4-2" }, "answer": [ { "answer": "Gluconeogenesis", "description": "Gluconeogenesis", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-70263", "source": "Reactome" } ], "type": "one-hop" }, { "question": "In what pathways has the protein Q5HYK7 been annotated?", "source": "Q5HYK7", "entities": { "protein": "Q5HYK7" }, "answer": [ { "answer": "Golgi Associated Vesicle Biogenesis", "description": "Golgi Associated Vesicle Biogenesis", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-432722", "source": "Reactome" } ], "type": "one-hop" }, { "question": "Could you please specify the pathways in which the protein P54819 is annotated?", "source": "P54819", "entities": { "protein": "P54819" }, "answer": [ { "answer": "Adefovir Dipivoxil Metabolism Pathway", "description": "Drug Metabolism", "linkout": "http://smpdb.ca/view/SMP0000629", "source": "SMPDB" }, { "answer": "Tenofovir Metabolism Pathway", "description": "Drug Metabolism", "linkout": "http://smpdb.ca/view/SMP0000630", "source": "SMPDB" }, { "answer": "Interconversion of nucleotide di- and triphosphates", "description": "Interconversion of nucleotide di- and triphosphates", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-499943", "source": "Reactome" } ], "type": "one-hop" }, { "question": "What pathways include the protein Q05086?", "source": "Q05086", "entities": { "protein": "Q05086" }, "answer": [ { "answer": "Antigen processing: Ubiquitination & Proteasome degradation", "description": "Antigen processing: Ubiquitination & Proteasome degradation", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-983168", "source": "Reactome" } ], "type": "one-hop" }, { "question": "In which pathways is the protein Q01064 annotated?", "source": "Q01064", "entities": { "protein": "Q01064" }, "answer": [ { "answer": "cGMP effects", "description": "cGMP effects", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-418457", "source": "Reactome" }, { "answer": "Cam-PDE 1 activation", "description": "Cam-PDE 1 activation", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-111957", "source": "Reactome" }, { "answer": "G alpha (s) signalling events", "description": "G alpha (s) signalling events", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-418555", "source": "Reactome" } ], "type": "one-hop" }, { "question": "Can you identify the pathways where the protein P22532 is annotated?", "source": "P22532", "entities": { "protein": "P22532" }, "answer": [ { "answer": "Formation of the cornified envelope", "description": "Formation of the cornified envelope", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-6809371", "source": "Reactome" } ], "type": "one-hop" }, { "question": "In what pathways has the protein O75382 been annotated?", "source": "O75382", "entities": { "protein": "O75382" }, "answer": [ { "answer": "Interferon gamma signaling", "description": "Interferon gamma signaling", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-877300", "source": "Reactome" } ], "type": "one-hop" }, { "question": "Could you please specify the pathways in which the protein P34998 is annotated?", "source": "P34998", "entities": { "protein": "P34998" }, "answer": [ { "answer": "G alpha (s) signalling events", "description": "G alpha (s) signalling events", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-418555", "source": "Reactome" }, { "answer": "Class B/2 (Secretin family receptors)", "description": "Class B/2 (Secretin family receptors)", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-373080", "source": "Reactome" } ], "type": "one-hop" }, { "question": "What pathways include the protein P08579?", "source": "P08579", "entities": { "protein": "P08579" }, "answer": [ { "answer": "mRNA Splicing - Major Pathway", "description": "mRNA Splicing - Major Pathway", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-72163", "source": "Reactome" } ], "type": "one-hop" }, { "question": "In which pathways is the protein Q9Y2Z9 annotated?", "source": "Q9Y2Z9", "entities": { "protein": "Q9Y2Z9" }, "answer": [ { "answer": "Ubiquinone Biosynthesis", "description": "Metabolic", "linkout": "http://smpdb.ca/view/SMP0000065", "source": "SMPDB" }, { "answer": "Ubiquinol biosynthesis", "description": "Ubiquinol biosynthesis", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-2142789", "source": "Reactome" } ], "type": "one-hop" }, { "question": "Can you identify the pathways where the protein Q9Y4Z0 is annotated?", "source": "Q9Y4Z0", "entities": { "protein": "Q9Y4Z0" }, "answer": [ { "answer": "mRNA decay by 5' to 3' exoribonuclease", "description": "mRNA decay by 5' to 3' exoribonuclease", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-430039", "source": "Reactome" }, { "answer": "mRNA Splicing - Major Pathway", "description": "mRNA Splicing - Major Pathway", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-72163", "source": "Reactome" } ], "type": "one-hop" }, { "question": "In what pathways has the protein Q9H1K1 been annotated?", "source": "Q9H1K1", "entities": { "protein": "Q9H1K1" }, "answer": [ { "answer": "Maturation of replicase proteins", "description": "Maturation of replicase proteins", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-9694301", "source": "Reactome" } ], "type": "one-hop" }, { "question": "Could you please specify the pathways in which the protein P14927 is annotated?", "source": "P14927", "entities": { "protein": "P14927" }, "answer": [ { "answer": "Respiratory electron transport", "description": "Respiratory electron transport", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-611105", "source": "Reactome" } ], "type": "one-hop" }, { "question": "What pathways include the protein Q68CZ2?", "source": "Q68CZ2", "entities": { "protein": "Q68CZ2" }, "answer": [ { "answer": "MET interacts with TNS proteins", "description": "MET interacts with TNS proteins", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-8875513", "source": "Reactome" } ], "type": "one-hop" }, { "question": "In which pathways is the protein O15121 annotated?", "source": "O15121", "entities": { "protein": "O15121" }, "answer": [ { "answer": "Neutrophil degranulation", "description": "Neutrophil degranulation", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-6798695", "source": "Reactome" }, { "answer": "Sphingolipid de novo biosynthesis", "description": "Sphingolipid de novo biosynthesis", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-1660661", "source": "Reactome" } ], "type": "one-hop" }, { "question": "Can you identify the pathways where the protein Q9BUQ8 is annotated?", "source": "Q9BUQ8", "entities": { "protein": "Q9BUQ8" }, "answer": [ { "answer": "mRNA Splicing - Minor Pathway", "description": "mRNA Splicing - Minor Pathway", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-72165", "source": "Reactome" }, { "answer": "mRNA Splicing - Major Pathway", "description": "mRNA Splicing - Major Pathway", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-72163", "source": "Reactome" } ], "type": "one-hop" }, { "question": "In what pathways has the protein Q9NNW7 been annotated?", "source": "Q9NNW7", "entities": { "protein": "Q9NNW7" }, "answer": [ { "answer": "Detoxification of Reactive Oxygen Species", "description": "Detoxification of Reactive Oxygen Species", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-3299685", "source": "Reactome" } ], "type": "one-hop" }, { "question": "Could you please specify the pathways in which the protein Q9NPH9 is annotated?", "source": "Q9NPH9", "entities": { "protein": "Q9NPH9" }, "answer": [ { "answer": "Interleukin-20 family signaling", "description": "Interleukin-20 family signaling", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-8854691", "source": "Reactome" } ], "type": "one-hop" }, { "question": "What pathways include the protein Q8IYW5?", "source": "Q8IYW5", "entities": { "protein": "Q8IYW5" }, "answer": [ { "answer": "SUMOylation of DNA damage response and repair proteins", "description": "SUMOylation of DNA damage response and repair proteins", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-3108214", "source": "Reactome" }, { "answer": "G2/M DNA damage checkpoint", "description": "G2/M DNA damage checkpoint", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-69473", "source": "Reactome" }, { "answer": "Nonhomologous End-Joining (NHEJ)", "description": "Nonhomologous End-Joining (NHEJ)", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-5693571", "source": "Reactome" }, { "answer": "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "description": "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-5693565", "source": "Reactome" }, { "answer": "Processing of DNA double-strand break ends", "description": "Processing of DNA double-strand break ends", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-5693607", "source": "Reactome" } ], "type": "one-hop" }, { "question": "Could you tell me about the structure(s) of the protein P62256-1? PDB ID is ok.", "source": "P62256-1", "entities": { "protein": "P62256-1" }, "answer": [ { "link": "http://www.rcsb.org/structure/2Z5D", "answer": "2Z5D", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "What are the structure(s) of protein Q9H0M4-2? Just tell me the PDB ID.", "source": "Q9H0M4-2", "entities": { "protein": "Q9H0M4-2" }, "answer": [ { "link": "http://www.rcsb.org/structure/2RR4", "answer": "2RR4", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/2E61", "answer": "2E61", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "Please provide the PDB ID(s) of the structure(s) of the protein Q8NI60-4.", "source": "Q8NI60-4", "entities": { "protein": "Q8NI60-4" }, "answer": [ { "link": "http://www.rcsb.org/structure/4PED", "answer": "4PED", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/5I35", "answer": "5I35", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/7UDP", "answer": "7UDP", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/7UDQ", "answer": "7UDQ", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "What are the PDB ID(s) for the structure(s) of protein Q9ULV8-2?", "source": "Q9ULV8-2", "entities": { "protein": "Q9ULV8-2" }, "answer": [ { "link": "http://www.rcsb.org/structure/3OP0", "answer": "3OP0", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/3VRO", "answer": "3VRO", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/3VRR", "answer": "3VRR", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/3VRP", "answer": "3VRP", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/3VRN", "answer": "3VRN", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/3VRQ", "answer": "3VRQ", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "What is the PDB ID for protein Q9H0M0-1's structure, or if there are multiple, what are they?", "source": "Q9H0M0-1", "entities": { "protein": "Q9H0M0-1" }, "answer": [ { "link": "http://www.rcsb.org/structure/8EI4", "answer": "8EI4", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/6J1Y", "answer": "6J1Y", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/5HPS", "answer": "5HPS", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/2OP7", "answer": "2OP7", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/6J1X", "answer": "6J1X", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/1ND7", "answer": "1ND7", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/5HPT", "answer": "5HPT", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "Could you tell me about the structure(s) of the protein Q8TC59-1? PDB ID is ok.", "source": "Q8TC59-1", "entities": { "protein": "Q8TC59-1" }, "answer": [ { "link": "http://www.rcsb.org/structure/3O7X", "answer": "3O7X", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/3QIR", "answer": "3QIR", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "What are the structure(s) of protein Q14814-3? Just tell me the PDB ID.", "source": "Q14814-3", "entities": { "protein": "Q14814-3" }, "answer": [ { "link": "http://www.rcsb.org/structure/7X1N", "answer": "7X1N", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "Please provide the PDB ID(s) of the structure(s) of the protein Q96PK6-4.", "source": "Q96PK6-4", "entities": { "protein": "Q96PK6-4" }, "answer": [ { "link": "http://www.rcsb.org/structure/2DNP", "answer": "2DNP", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "What are the PDB ID(s) for the structure(s) of protein Q14008?", "source": "Q14008", "entities": { "protein": "Q14008" }, "answer": [ { "link": "http://www.rcsb.org/structure/4QMJ", "answer": "4QMJ", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/4QMI", "answer": "4QMI", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "What is the PDB ID for protein Q13620-2's structure, or if there are multiple, what are they?", "source": "Q13620-2", "entities": { "protein": "Q13620-2" }, "answer": [ { "link": "http://www.rcsb.org/structure/4A0C", "answer": "4A0C", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/2DO7", "answer": "2DO7", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/4A64", "answer": "4A64", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/4A0L", "answer": "4A0L", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/8EI1", "answer": "8EI1", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "Could you tell me about the structure(s) of the protein Q92564-3? PDB ID is ok.", "source": "Q92564-3", "entities": { "protein": "Q92564-3" }, "answer": [ { "link": "http://www.rcsb.org/structure/5V89", "answer": "5V89", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "What are the structure(s) of protein Q8TDZ2-1? Just tell me the PDB ID.", "source": "Q8TDZ2-1", "entities": { "protein": "Q8TDZ2-1" }, "answer": [ { "link": "http://www.rcsb.org/structure/2CO8", "answer": "2CO8", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/5LE0", "answer": "5LE0", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/1WYL", "answer": "1WYL", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/6KU0", "answer": "6KU0", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/8HLO", "answer": "8HLO", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/5LPN", "answer": "5LPN", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/2DK9", "answer": "2DK9", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "Please provide the PDB ID(s) of the structure(s) of the protein P62258.", "source": "P62258", "entities": { "protein": "P62258" }, "answer": [ { "link": "http://www.rcsb.org/structure/8DP5", "answer": "8DP5", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/8DGN", "answer": "8DGN", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/8DGM", "answer": "8DGM", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/7C8E", "answer": "7C8E", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/8DGP", "answer": "8DGP", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/2BR9", "answer": "2BR9", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/3UBW", "answer": "3UBW", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/6EIH", "answer": "6EIH", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/3UAL", "answer": "3UAL", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/7V9B", "answer": "7V9B", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "What are the PDB ID(s) for the structure(s) of protein Q9BWV1-1?", "source": "Q9BWV1-1", "entities": { "protein": "Q9BWV1-1" }, "answer": [ { "link": "http://www.rcsb.org/structure/3N1G", "answer": "3N1G", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/3N1M", "answer": "3N1M", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/3N1P", "answer": "3N1P", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "What is the PDB ID for protein O75888-1's structure, or if there are multiple, what are they?", "source": "O75888-1", "entities": { "protein": "O75888-1" }, "answer": [ { "link": "http://www.rcsb.org/structure/4ZCH", "answer": "4ZCH", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "Could you tell me about the structure(s) of the protein Q96HL8? PDB ID is ok.", "source": "Q96HL8", "entities": { "protein": "Q96HL8" }, "answer": [ { "link": "http://www.rcsb.org/structure/2D8H", "answer": "2D8H", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "What are the structure(s) of protein O75128-7? Just tell me the PDB ID.", "source": "O75128-7", "entities": { "protein": "O75128-7" }, "answer": [ { "link": "http://www.rcsb.org/structure/4PL8", "answer": "4PL8", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "Please provide the PDB ID(s) of the structure(s) of the protein Q9NXF7.", "source": "Q9NXF7", "entities": { "protein": "Q9NXF7" }, "answer": [ { "link": "http://www.rcsb.org/structure/8G46", "answer": "8G46", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/8OV6", "answer": "8OV6", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "What are the PDB ID(s) for the structure(s) of protein Q9NQA5-2?", "source": "Q9NQA5-2", "entities": { "protein": "Q9NQA5-2" }, "answer": [ { "link": "http://www.rcsb.org/structure/5OEO", "answer": "5OEO", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "What is the PDB ID for protein A2KBC1's structure, or if there are multiple, what are they?", "source": "A2KBC1", "entities": { "protein": "A2KBC1" }, "answer": [ { "link": "http://www.rcsb.org/structure/7AH1", "answer": "7AH1", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "Could you tell me about the structure(s) of the protein P08575-6? PDB ID is ok.", "source": "P08575-6", "entities": { "protein": "P08575-6" }, "answer": [ { "link": "http://www.rcsb.org/structure/5FN7", "answer": "5FN7", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/1YGR", "answer": "1YGR", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/5FMV", "answer": "5FMV", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/5FN6", "answer": "5FN6", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/1YGU", "answer": "1YGU", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "What are the structure(s) of protein Q92600-2? Just tell me the PDB ID.", "source": "Q92600-2", "entities": { "protein": "Q92600-2" }, "answer": [ { "link": "http://www.rcsb.org/structure/4CRV", "answer": "4CRV", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/6HON", "answer": "6HON", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/6HOM", "answer": "6HOM", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/5ONA", "answer": "5ONA", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/4CRU", "answer": "4CRU", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/5ONB", "answer": "5ONB", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/4CT7", "answer": "4CT7", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/4CT6", "answer": "4CT6", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/2FV2", "answer": "2FV2", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/5LSW", "answer": "5LSW", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "Please provide the PDB ID(s) of the structure(s) of the protein Q68E01-3.", "source": "Q68E01-3", "entities": { "protein": "Q68E01-3" }, "answer": [ { "link": "http://www.rcsb.org/structure/6WLG", "answer": "6WLG", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/4OWW", "answer": "4OWW", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/4OWX", "answer": "4OWX", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/4OWT", "answer": "4OWT", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/7BV7", "answer": "7BV7", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "What are the PDB ID(s) for the structure(s) of protein Q9BXY0?", "source": "Q9BXY0", "entities": { "protein": "Q9BXY0" }, "answer": [ { "link": "http://www.rcsb.org/structure/8FKT", "answer": "8FKT", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/8FKR", "answer": "8FKR", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/8FKP", "answer": "8FKP", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/8FKV", "answer": "8FKV", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "What is the PDB ID for protein Q9H4L5-6's structure, or if there are multiple, what are they?", "source": "Q9H4L5-6", "entities": { "protein": "Q9H4L5-6" }, "answer": [ { "link": "http://www.rcsb.org/structure/7DEJ", "answer": "7DEJ", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/7DEI", "answer": "7DEI", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/7CYZ", "answer": "7CYZ", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "Could you tell me about the structure(s) of the protein P52757-7? PDB ID is ok.", "source": "P52757-7", "entities": { "protein": "P52757-7" }, "answer": [ { "link": "http://www.rcsb.org/structure/1XA6", "answer": "1XA6", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "What are the structure(s) of protein Q8WTW4-1? Just tell me the PDB ID.", "source": "Q8WTW4-1", "entities": { "protein": "Q8WTW4-1" }, "answer": [ { "link": "http://www.rcsb.org/structure/8FW5", "answer": "8FW5", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/6CET", "answer": "6CET", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/7T3B", "answer": "7T3B", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/7T3C", "answer": "7T3C", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/6CES", "answer": "6CES", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/7T3A", "answer": "7T3A", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "Please provide the PDB ID(s) of the structure(s) of the protein Q9UGV2.", "source": "Q9UGV2", "entities": { "protein": "Q9UGV2" }, "answer": [ { "link": "http://www.rcsb.org/structure/6L4G", "answer": "6L4G", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/6L4H", "answer": "6L4H", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/6L4B", "answer": "6L4B", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "What are the PDB ID(s) for the structure(s) of protein Q09013-8?", "source": "Q09013-8", "entities": { "protein": "Q09013-8" }, "answer": [ { "link": "http://www.rcsb.org/structure/1WT6", "answer": "1WT6", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/2VD5", "answer": "2VD5", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "What is the PDB ID for protein Q9Y3E7's structure, or if there are multiple, what are they?", "source": "Q9Y3E7", "entities": { "protein": "Q9Y3E7" }, "answer": [ { "link": "http://www.rcsb.org/structure/3FRV", "answer": "3FRV", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/2GD5", "answer": "2GD5", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/2XZE", "answer": "2XZE", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/7ZCG", "answer": "7ZCG", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/3FRT", "answer": "3FRT", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/7ZCH", "answer": "7ZCH", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "Could you tell me about the structure(s) of the protein Q9BSC4-4? PDB ID is ok.", "source": "Q9BSC4-4", "entities": { "protein": "Q9BSC4-4" }, "answer": [ { "link": "http://www.rcsb.org/structure/7MQ8", "answer": "7MQ8", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/7MQ9", "answer": "7MQ9", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "What are the structure(s) of protein O43307-1? Just tell me the PDB ID.", "source": "O43307-1", "entities": { "protein": "O43307-1" }, "answer": [ { "link": "http://www.rcsb.org/structure/2YSQ", "answer": "2YSQ", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "Please provide the PDB ID(s) of the structure(s) of the protein Q8NFQ8.", "source": "Q8NFQ8", "entities": { "protein": "Q8NFQ8" }, "answer": [ { "link": "http://www.rcsb.org/structure/5J1T", "answer": "5J1T", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/5J1S", "answer": "5J1S", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "What are the PDB ID(s) for the structure(s) of protein Q5SYB0-2?", "source": "Q5SYB0-2", "entities": { "protein": "Q5SYB0-2" }, "answer": [ { "link": "http://www.rcsb.org/structure/4G2V", "answer": "4G2V", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/2EDV", "answer": "2EDV", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "What is the PDB ID for protein Q96ST2-1's structure, or if there are multiple, what are they?", "source": "Q96ST2-1", "entities": { "protein": "Q96ST2-1" }, "answer": [ { "link": "http://www.rcsb.org/structure/6ZV4", "answer": "6ZV4", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/6EMR", "answer": "6EMR", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/6ZV1", "answer": "6ZV1", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "Could you tell me about the structure(s) of the protein P20020? PDB ID is ok.", "source": "P20020", "entities": { "protein": "P20020" }, "answer": [ { "link": "http://www.rcsb.org/structure/6A69", "answer": "6A69", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "What are the structure(s) of protein Q49AH0-2? Just tell me the PDB ID.", "source": "Q49AH0-2", "entities": { "protein": "Q49AH0-2" }, "answer": [ { "link": "http://www.rcsb.org/structure/4BIT", "answer": "4BIT", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/2W50", "answer": "2W50", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/2LPN", "answer": "2LPN", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "Please provide the PDB ID(s) of the structure(s) of the protein O15264.", "source": "O15264", "entities": { "protein": "O15264" }, "answer": [ { "link": "http://www.rcsb.org/structure/4EYM", "answer": "4EYM", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/5EKO", "answer": "5EKO", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/4YNO", "answer": "4YNO", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/4EYJ", "answer": "4EYJ", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/4MYG", "answer": "4MYG", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/3COI", "answer": "3COI", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/5EKN", "answer": "5EKN", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "What are the PDB ID(s) for the structure(s) of protein Q8WV16?", "source": "Q8WV16", "entities": { "protein": "Q8WV16" }, "answer": [ { "link": "http://www.rcsb.org/structure/3I8C", "answer": "3I8C", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "What is the PDB ID for protein Q9NQH7's structure, or if there are multiple, what are they?", "source": "Q9NQH7", "entities": { "protein": "Q9NQH7" }, "answer": [ { "link": "http://www.rcsb.org/structure/5X49", "answer": "5X49", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "Could you tell me about the structure(s) of the protein P41587? PDB ID is ok.", "source": "P41587", "entities": { "protein": "P41587" }, "answer": [ { "link": "http://www.rcsb.org/structure/7WBJ", "answer": "7WBJ", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/7VQX", "answer": "7VQX", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/2X57", "answer": "2X57", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "What are the structure(s) of protein P05771-1? Just tell me the PDB ID.", "source": "P05771-1", "entities": { "protein": "P05771-1" }, "answer": [ { "link": "http://www.rcsb.org/structure/2I0E", "answer": "2I0E", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "Please provide the PDB ID(s) of the structure(s) of the protein Q30201-7.", "source": "Q30201-7", "entities": { "protein": "Q30201-7" }, "answer": [ { "link": "http://www.rcsb.org/structure/1A6Z", "answer": "1A6Z", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/1DE4", "answer": "1DE4", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "What are the PDB ID(s) for the structure(s) of protein Q5VZK9-4?", "source": "Q5VZK9-4", "entities": { "protein": "Q5VZK9-4" }, "answer": [ { "link": "http://www.rcsb.org/structure/3LK3", "answer": "3LK3", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/3LK2", "answer": "3LK2", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "What is the PDB ID for protein Q6IQ49-1's structure, or if there are multiple, what are they?", "source": "Q6IQ49-1", "entities": { "protein": "Q6IQ49-1" }, "answer": [ { "link": "http://www.rcsb.org/structure/8C6J", "answer": "8C6J", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/7N99", "answer": "7N99", "source": "Uniprot" }, { "link": "http://www.rcsb.org/structure/6QDV", "answer": "6QDV", "source": "Uniprot" } ], "type": "one-hop" }, { "question": "Can you list the diseases the protein Q8TD47 is associated with?", "source": "Q8TD47", "entities": { "protein": "Q8TD47" }, "answer": [ { "answer": "Y-linked spermatogenic failure 2", "description": "A spermatogenic failure that is characterized by nonobstroctive azoospermia or oligozoospermia that has_material_basis_in interstitial deletions on the Yq11.221 chromosomal region. [url:https\\://www.ncbi.nlm.nih.gov/pubmed/19737515]" } ], "type": "one-hop" }, { "question": "Which diseases is the protein P0DPB3 associated with?", "source": "P0DPB3", "entities": { "protein": "P0DPB3" }, "answer": [ { "answer": "chromophobe renal cell carcinoma", "description": "A renal cell carcinoma that has_material_basis_in chromophobe cell that appear pale when viewed under microscope, but that are larger and display different features than clear cells. [url:http\\://www.cancer.org/acs/groups/cid/documents/webcontent/003107-pdf.pdf, url:https\\://rarediseases.info.nih.gov/diseases/6064/chromophobe-renal-cell-carcinoma]" }, { "answer": "celiac disease", "description": "An autoimmune disease of gastrointestinal tract that is caused by a reaction located_in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has_symptom abdominal pain, has_symptom constipation, has_symptom diarrhea, has_symptom nausea and vomiting, and has_symptom loss of appetite. [url:http\\://en.wikipedia.org/wiki/Coeliac_disease, url:http\\://www.celiac.org/, url:http\\://www.mayoclinic.com/health/celiac-disease/DS00319, url:http\\://www.nlm.nih.gov/medlineplus/ency/article/000233.htm, url:https\\://www.niddk.nih.gov/health-information/digestive-diseases/celiac-disease]" }, { "answer": "familial adenomatous polyposis", "description": "An intestinal disease that has_material_basis_in mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer. [url:http\\://en.wikipedia.org/wiki/Familial_adenomatous_polyposis, url:http\\://www.omim.org/entry/175100?search=adenomatous%20polyposis]" }, { "answer": "familial adenomatous polyposis 1", "description": "A familial adenomatous polyposis that has_material_basis_in heterozygous mutation in the APC gene on chromosome 5q22. [url:https\\://ghr.nlm.nih.gov/condition/familial-adenomatous-polyposis, url:https\\://www.ncbi.nlm.nih.gov/pubmed/1651563]" }, { "answer": "primary biliary cholangitis", "description": "A liver cirrhosis characterized by chronic and slow progressive destruction of intrahepatic bile ducts. [url:http\\://en.wikipedia.org/wiki/Primary_biliary_cirrhosis, url:http\\://www.merckmanuals.com/professional/hepatic_and_biliary_disorders/fibrosis_and_cirrhosis/primary_biliary_cirrhosis_pbc.html?qt=primary%20biliary%20cirrhosis&alt=sh, url:https\\://www.mayoclinic.org/diseases-conditions/primary-biliary-cholangitis-pbc/symptoms-causes/syc-20376874]" } ], "type": "one-hop" }, { "question": "Could you please specify which diseases the protein A0A1B0GTL2 is associated with?", "source": "A0A1B0GTL2", "entities": { "protein": "A0A1B0GTL2" }, "answer": [ { "answer": "ovarian cancer", "description": "A female reproductive organ cancer that is located_in the ovary. [url:http\\://www.cancer.gov/dictionary?CdrID=445074]" }, { "answer": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver. [url:http\\://en.wikipedia.org/wiki/Liver]" }, { "answer": "ovarian carcinoma", "description": "An ovarian cancer that has_material_basis_in epithelial tissue and is located_in the ovary. [url:https\\://www.cancer.gov/types/ovarian]" }, { "answer": "cancer", "description": "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis. [url:http\\://en.wikipedia.org/wiki/cancer, url:http\\://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=cancer]" }, { "answer": "hepatocellular carcinoma", "description": "A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver. [url:http\\://cancergenome.nih.gov/cancersselected/LiverHepatocellularCarcinoma, url:http\\://en.wikipedia.org/wiki/Hepatocellular_carcinoma, url:http\\://www.omim.org/entry/114550]" } ], "type": "one-hop" }, { "question": "What are the diseases that the protein O43812 is associated with?", "source": "O43812", "entities": { "protein": "O43812" }, "answer": [ { "answer": "rhabdomyosarcoma", "description": "A skeletal muscle cancer that arise from skeletal muscle progenitors. [url:http\\://en.wikipedia.org/wiki/Rhabdomyosarcoma, url:https\\://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425116/]" } ], "type": "one-hop" }, { "question": "Can you identify diseases that the protein Q5J8X5 is associated with?", "source": "Q5J8X5", "entities": { "protein": "Q5J8X5" }, "answer": [ { "answer": "cardiomyopathy", "description": "A heart disease and a myopathy that is characterized by deterioration of the function of the heart muscle. [url:http\\://en.wikipedia.org/wiki/Cardiomyopathy, url:http\\://www.nhlbi.nih.gov/health/health-topics/topics/cm/]" }, { "answer": "aortic valve disease", "description": "A heart valve disease that is located_in the aortic valve. [url:https\\://www.mayoclinic.org/diseases-conditions/aortic-valve-disease/symptoms-causes/syc-20355117]" }, { "answer": "familial hypertrophic cardiomyopathy", "description": "A hypertrophic cardiomyopathy that is characterized by thickening of the heart muscle and has_material_basis_in autosomal dominant inheritance of one or more gene mutations. [url:https\\://ghr.nlm.nih.gov/condition/familial-hypertrophic-cardiomyopathy#genes]" }, { "answer": "aortic valve stenosis", "description": "An aortic valve disease that is characterized by narrowing of the heart's aortic valve opening. [url:http\\://en.wikipedia.org/wiki/Aortic_valve_stenosis, url:https\\://rarediseases.info.nih.gov/diseases/5830/aortic-valve-stenosis]" }, { "answer": "heart valve disease", "description": "A heart disease involving one or more of the four valves of the heart (the aortic and mitral valves on the left and the pulmonary and tricuspid valves on the right). [url:http\\://en.wikipedia.org/wiki/Heart_valve_disease]" }, { "answer": "aortic disease", "description": "An artery disease that is characterized by degeneration of the cells composing the aortic wall. [url:http\\://www.hopkinsmedicine.org/heart_vascular_institute/conditions_treatments/conditions/aorta.html]" }, { "answer": "hypertrophic cardiomyopathy", "description": "An intrinsic cardiomyopathy that is characterized by abnormal thickening (hypertrophy) of the heart without any obvious cause. [url:http\\://en.wikipedia.org/wiki/Hypertrophic_cardiomyopathy, url:http\\://www.mayoclinic.org/diseases-conditions/hypertrophic-cardiomyopathy/basics/definition/con-20030747, url:http\\://www.nhlbi.nih.gov/health/health-topics/topics/cm/]" }, { "answer": "intrinsic cardiomyopathy", "description": "A cardiomyopathy that is characterized as weakness in the muscle of the heart that is not due to an identifiable external cause. [url:https\\://en.wikipedia.org/wiki/Cardiomyopathy]" } ], "type": "one-hop" }, { "question": "Can you list the diseases the protein H0YIS7 is associated with?", "source": "H0YIS7", "entities": { "protein": "H0YIS7" }, "answer": [ { "answer": "lupus erythematosus", "description": "An autoimmune disease that is characterized by a constellation of findings that include elevated antibodies to nuclear antigens, antiphospholipids, low complement levels, ulcers, non-scarring alopecia, renal or neurologic damage, and low white blood cell and platelet counts, has_symptom rashes, fatigue, arthritis, hair loss, seizures, and symptoms related to affected organs. [url:https\\://www.ncbi.nlm.nih.gov/pubmed/29366725]" }, { "answer": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland. [url:http\\://en.wikipedia.org/wiki/Breast_cancer, url:http\\://en.wikipedia.org/wiki/Mammary, url:http\\://www.cancer.gov/cancertopics/types/breast, url:http\\://www.nlm.nih.gov/medlineplus/breastcancer.html, url:https\\://www.genome.gov/Genetic-Disorders/Breast-Cancer]" }, { "answer": "autoimmune disease of musculoskeletal system", "description": "An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the musculoskeletal system. [url:https\\://www.ncbi.nlm.nih.gov/books/NBK459447/]" }, { "answer": "thoracic disease", "description": "A disease of anatomical entity that is located_in the thoracic cavity. [url:http\\://en.wikipedia.org/wiki/Thoracic_cavity]" }, { "answer": "thoracic cancer", "description": "An organ system cancer located_in the thoracic cavity that develops in the different types of cells within the lungs, as well as less common cancers of the esophagus, the trachea, or the chest wall. [url:https\\://radonc.ucsf.edu/thoracic-cancers]" }, { "answer": "systemic lupus erythematosus", "description": "A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart. [url:http\\://en.wikipedia.org/wiki/Systemic_lupus_erythematosus]" }, { "answer": "breast disease", "description": "A thoracic disease that is located_in the breast. [url:http\\://www.nlm.nih.gov/medlineplus/breastdiseases.html]" } ], "type": "one-hop" }, { "question": "Which diseases is the protein P0DMT0 associated with?", "source": "P0DMT0", "entities": { "protein": "P0DMT0" }, "answer": [ { "answer": "periodontitis", "description": "periodontitis" } ], "type": "one-hop" }, { "question": "Could you please specify which diseases the protein F2Z333 is associated with?", "source": "F2Z333", "entities": { "protein": "F2Z333" }, "answer": [ { "answer": "facial hemiatrophy", "description": "facial hemiatrophy" }, { "answer": "type 2 diabetes mellitus", "description": "A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. [url:http\\://en.wikipedia.org/wiki/Diabetes, url:http\\://en.wikipedia.org/wiki/Diabetes_mellitus_type_2]" }, { "answer": "infertility", "description": "infertility" }, { "answer": "cranial nerve disease", "description": "A neuropathy that is located_in one of the twelve cranial nerves. [url:http\\://en.wikipedia.org/wiki/Cranial_nerve_disease, url:http\\://www.ncbi.nlm.nih.gov/mesh/68003389]" }, { "answer": "facial nerve disease", "description": "A cranial nerve disease that is located_in the facial nerve (seventh cranial nerve. [url:https\\://ent.uci.edu/more-at-uc-irvine/conditions/facial-nerve-disorders.asp]" } ], "type": "one-hop" }, { "question": "What are the diseases that the protein Q674R7 is associated with?", "source": "Q674R7", "entities": { "protein": "Q674R7" }, "answer": [ { "answer": "thyroid gland carcinoma", "description": "A thyroid gland cancer that has_material_basis_in epithelial cells. [url:http\\://en.wikipedia.org/wiki/Carcinoma]" }, { "answer": "thyroid adenoma", "description": "An endocrine organ benign neoplasm that is located_in the thyroid and derives_from glandular epithelial cells. [url:https\\://www.sciencedirect.com/topics/veterinary-science-and-veterinary-medicine/thyroid-adenoma]" }, { "answer": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage. [url:http\\://en.wikipedia.org/wiki/Thyroid_gland]" }, { "answer": "sporadic breast cancer", "description": "A breast carcinoma that occurs in people who do not have a family history of that cancer or an inherited change in their DNA that would increase their risk for that cancer. [url:https\\://www.cancer.gov/publications/dictionaries/cancer-terms/def/sporadic-cancer]" }, { "answer": "clear cell renal cell carcinoma", "description": "A renal cell carcinoma that has_material_basis_in cells that appear very pale or clear when examined under microscope. [url:http\\://www.cancer.gov/dictionary?CdrID=45063, url:https\\://cancergenome.nih.gov/cancersselected/kidneyclearcell]" }, { "answer": "nonpapillary renal cell carcinoma", "description": "A hereditary renal cell carcinoma that has_material_basis_in a loss of 3p13-pter sequences. [url:https\\://www.ncbi.nlm.nih.gov/pubmed/2921777, url:https\\://www.ncbi.nlm.nih.gov/pubmed/8415591]" }, { "answer": "renal cell carcinoma", "description": "A renal carcinoma that has_material_basis_in the lining of the proximal convoluted renal tubule of the kidney. [url:http\\://en.wikipedia.org/wiki/Renal_cell_carcinoma, url:http\\://www.cancer.gov/dictionary?CdrID=661352]" } ], "type": "one-hop" }, { "question": "Can you identify diseases that the protein Q9NV23 is associated with?", "source": "Q9NV23", "entities": { "protein": "Q9NV23" }, "answer": [ { "answer": "migraine", "description": "A brain disease that is characterized by moderate to severe headaches, nausea, extreme sensitivity to light and sound and intense unilaterial throbbing or pulsing. [url:http\\://en.wikipedia.org/wiki/Migraine, url:http\\://www.mayoclinic.com/health/migraine-headache/DS00120]" } ], "type": "one-hop" }, { "question": "Can you list the diseases the protein P0DPH7 is associated with?", "source": "P0DPH7", "entities": { "protein": "P0DPH7" }, "answer": [ { "answer": "Clouston syndrome", "description": "An ectodermal dysplasia that is characterized by abnormalities of the hair, nails, and skin, with the teeth and sweat glands being unaffected and that has_material_basis_in heterozygous mutation in the GJB6 gene, which encodes connexin-30, on chromosome 13q12. [url:https\\://pubmed.ncbi.nlm.nih.gov/8845850/]" }, { "answer": "lung cancer", "description": "A respiratory system cancer that is located_in the lung. [url:http\\://en.wikipedia.org/wiki/Lung_cancer]" }, { "answer": "cardiovascular system disease", "description": "A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. [url:http\\://en.wikipedia.org/wiki/Circulatory_system]" }, { "answer": "keratoconus", "description": "A corneal disease characterized by structural changes within the cornea causing it to thin and change, leading to a protruding conical shape. [url:http\\://en.wikipedia.org/wiki/Keratoconus, url:http\\://ghr.nlm.nih.gov/glossary=keratoconus]" }, { "answer": "Kabuki syndrome", "description": "A syndrome characterized by multiple congenital anomalies and mental retardation. Other characteristics include a peculiar facial gestalt, short stature, skeletal and visceral abnormalities, cardiac anomalies, and immunological defects. [url:http\\://ghr.nlm.nih.gov/condition/kabuki-syndrome, url:https\\://en.wikipedia.org/wiki/Kabuki_syndrome, url:https\\://www.ncbi.nlm.nih.gov/pubmed/25281733, url:https\\://www.ncbi.nlm.nih.gov/pubmed/25972376, url:https\\://www.ncbi.nlm.nih.gov/pubmed/26512256]" }, { "answer": "lung non-small cell carcinoma", "description": "A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma. [url:http\\://en.wikipedia.org/wiki/Non-small-cell_lung_carcinoma]" }, { "answer": "ventricular septal defect", "description": "A heart septal defect characterized by an opening in the interventricular septum, causing a shunt between ventricles. [url:http\\://en.wikipedia.org/wiki/Ventricular_septal_defect, url:http\\://www.merckmanuals.com/professional/pediatrics/congenital_cardiovascular_anomalies/ventricular_septal_defect_vsd.html]" }, { "answer": "Kawasaki disease", "description": "A lymphadenitis characterized by swelling of cervical lymph nodes in infants and young children and inflammation of medium-sized blood vessels located_in body, has_symptom fever, has_symptom congestion of ocular conjunctivae, has_symptom reddening of lips, has_symptom reddening of oral cavity, has_symptom protuberance of tongue papillae and has_symptom edema of extremities. [url:http\\://en.wikipedia.org/wiki/Kawasaki_disease]" } ], "type": "one-hop" }, { "question": "Which diseases is the protein A6NKQ9 associated with?", "source": "A6NKQ9", "entities": { "protein": "A6NKQ9" }, "answer": [ { "answer": "cancer", "description": "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis. [url:http\\://en.wikipedia.org/wiki/cancer, url:http\\://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=cancer]" }, { "answer": "ovarian cancer", "description": "A female reproductive organ cancer that is located_in the ovary. [url:http\\://www.cancer.gov/dictionary?CdrID=445074]" }, { "answer": "ovarian carcinoma", "description": "An ovarian cancer that has_material_basis_in epithelial tissue and is located_in the ovary. [url:https\\://www.cancer.gov/types/ovarian]" }, { "answer": "gestational trophoblastic neoplasm", "description": "gestational trophoblastic neoplasm" }, { "answer": "embryoma", "description": "A carcinosarcoma and embryonal cancer that is located_in embryonic tissue and results_in a mass of rapidly growing cells. [url:http\\://en.wikipedia.org/wiki/Embryoma]" } ], "type": "one-hop" }, { "question": "Could you please specify which diseases the protein D6RAR5 is associated with?", "source": "D6RAR5", "entities": { "protein": "D6RAR5" }, "answer": [ { "answer": "muscular disease", "description": "A musculoskeletal system disease that affects the muscles. [url:http\\://www.nlm.nih.gov/medlineplus/muscledisorders.html]" }, { "answer": "muscular dystrophy", "description": "A myopathy is characterized by progressive skeletal muscle weakness degeneration. [url:http\\://en.wikipedia.org/wiki/Muscular_dystrophy, url:http\\://www.ninds.nih.gov/disorders/md/md.htm]" }, { "answer": "muscle tissue disease", "description": "A muscular disease located in the muscle tissue. [url:https\\://medlineplus.gov/muscledisorders.html]" }, { "answer": "myopathy", "description": "A muscular disease in which the muscle fibers do not function resulting in muscular weakness. [url:http\\://en.wikipedia.org/wiki/Myopathy]" }, { "answer": "facioscapulohumeral muscular dystrophy", "description": "facioscapulohumeral muscular dystrophy" } ], "type": "one-hop" }, { "question": "What are the diseases that the protein Q70UQ0 is associated with?", "source": "Q70UQ0", "entities": { "protein": "Q70UQ0" }, "answer": [ { "answer": "cancer", "description": "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis. [url:http\\://en.wikipedia.org/wiki/cancer, url:http\\://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=cancer]" }, { "answer": "mixed glioma", "description": "mixed glioma" }, { "answer": "high grade glioma", "description": "A cell type cancer that has_material_basis_in glial cells and is located in brain or located in spine. [url:http\\://en.wikipedia.org/wiki/Malignant_glioma]" }, { "answer": "embryoma", "description": "A carcinosarcoma and embryonal cancer that is located_in embryonic tissue and results_in a mass of rapidly growing cells. [url:http\\://en.wikipedia.org/wiki/Embryoma]" }, { "answer": "central nervous system cancer", "description": "A nervous system cancer that is located_in the central nervous system. [url:http\\://en.wikipedia.org/wiki/Central_nervous_system]" } ], "type": "one-hop" }, { "question": "Can you identify diseases that the protein P0C2Y1 is associated with?", "source": "P0C2Y1", "entities": { "protein": "P0C2Y1" }, "answer": [ { "answer": "neuroblastoma", "description": "An autonomic nervous system neoplasm that derives_from immature nerve cells. [url:http\\://www.cancer.gov/cancertopics/types/neuroblastoma]" } ], "type": "one-hop" }, { "question": "Can you list the diseases the protein A8MTT3 is associated with?", "source": "A8MTT3", "entities": { "protein": "A8MTT3" }, "answer": [ { "answer": "endocrine gland cancer", "description": "An organ system cancer located_in endocrine system that is characterized by uncontrolled cellular proliferation of the hormone producing glands of the endocrine system. [url:http\\://en.wikipedia.org/wiki/Endocrine_system]" }, { "answer": "hepatobiliary disease", "description": "A gastrointestinal system disease that is located_in the liver and/or biliary tract. [url:http\\://en.wikipedia.org/wiki/Hepato-biliary_diseases]" }, { "answer": "liver disease", "description": "liver disease" }, { "answer": "hepatobiliary system cancer", "description": "A gastrointestinal system cancer that is located_in the hepatobiliary system. [url:https\\://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461147/]" }, { "answer": "gastrointestinal system cancer", "description": "An organ system cancer located_in gastrointestinal tract that is manifested in organs of the gastrointestinal system. [url:http\\://en.wikipedia.org/wiki/Human_gastrointestinal_tract]" }, { "answer": "organ system cancer", "description": "A cancer that is classified based on the organ it starts in. [url:https\\://www.cancer.gov/types/by-body-location]" }, { "answer": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver. [url:http\\://en.wikipedia.org/wiki/Liver]" }, { "answer": "pancreatic agenesis", "description": "A pancreas disease that is characterized by the failure of the pancreas to develop prior to birth. [url:http\\://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062962/pdf/emss-58937.pdf]" }, { "answer": "gastrointestinal system disease", "description": "A disease of anatomical entity that is located_in the gastrointestinal tract. [url:http\\://en.wikipedia.org/wiki/Human_gastrointestinal_tract]" } ], "type": "one-hop" }, { "question": "Which diseases is the protein K7ERJ3 associated with?", "source": "K7ERJ3", "entities": { "protein": "K7ERJ3" }, "answer": [ { "answer": "bronchial disease", "description": "A lower respiratory tract disease that affects the airways leading into the lungs, which is caused due to inflammation of the bronchi and bronchioles, infection, or blockage. [url:https\\://www.ncbi.nlm.nih.gov/pubmed/11685087]" }, { "answer": "cystic fibrosis", "description": "A syndrome that is characterized by the buildup of thick, sticky mucus that can damage many organs. [url:http\\://en.wikipedia.org/wiki/Cystic_fibrosis, url:http\\://ghr.nlm.nih.gov/condition/cystic-fibrosis, url:http\\://www.nhlbi.nih.gov/health/health-topics/topics/cf/, url:https\\://www.genome.gov/Genetic-Disorders/Cystic-Fibrosis]" }, { "answer": "asthma", "description": "A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing. [url:http\\://www.nhlbi.nih.gov/health/dci/Diseases/Asthma/Asthma_WhatIs.html, url:https\\://www.ncbi.nlm.nih.gov/books/NBK430901/, url:https\\://www.ncbi.nlm.nih.gov/books/NBK7223/]" } ], "type": "one-hop" }, { "question": "Could you please specify which diseases the protein Q8N328 is associated with?", "source": "Q8N328", "entities": { "protein": "Q8N328" }, "answer": [ { "answer": "hepatocellular carcinoma", "description": "A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver. [url:http\\://cancergenome.nih.gov/cancersselected/LiverHepatocellularCarcinoma, url:http\\://en.wikipedia.org/wiki/Hepatocellular_carcinoma, url:http\\://www.omim.org/entry/114550]" }, { "answer": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland. [url:http\\://en.wikipedia.org/wiki/Breast_cancer, url:http\\://en.wikipedia.org/wiki/Mammary, url:http\\://www.cancer.gov/cancertopics/types/breast, url:http\\://www.nlm.nih.gov/medlineplus/breastcancer.html, url:https\\://www.genome.gov/Genetic-Disorders/Breast-Cancer]" }, { "answer": "craniosynostosis", "description": "A synostosis that results_in premature fusion located_in skull. [url:http\\://en.wikipedia.org/wiki/Craniosynostosis, url:http\\://www.mayoclinic.com/health/craniosynostosis/DS00959, url:http\\://www.ninds.nih.gov/disorders/craniosynostosis/craniosynostosis.htm, url:http\\://www.nlm.nih.gov/medlineplus/ency/article/001590.htm]" }, { "answer": "Cockayne syndrome", "description": "A syndrome that is characterized by an abnormally small head size (microcephaly), a failure to gain weight and grow at the expected rate (failure to thrive) leading to very short stature, and delayed development. [url:http\\://en.wikipedia.org/wiki/Cockayne_syndrome, url:https\\://medlineplus.gov/genetics/condition/cockayne-syndrome/, url:https\\://www.ncbi.nlm.nih.gov/books/NBK1342/]" }, { "answer": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver. [url:http\\://en.wikipedia.org/wiki/Liver]" } ], "type": "one-hop" }, { "question": "What are the diseases that the protein A0A075B734 is associated with?", "source": "A0A075B734", "entities": { "protein": "A0A075B734" }, "answer": [ { "answer": "breast disease", "description": "A thoracic disease that is located_in the breast. [url:http\\://www.nlm.nih.gov/medlineplus/breastdiseases.html]" }, { "answer": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland. [url:http\\://en.wikipedia.org/wiki/Breast_cancer, url:http\\://en.wikipedia.org/wiki/Mammary, url:http\\://www.cancer.gov/cancertopics/types/breast, url:http\\://www.nlm.nih.gov/medlineplus/breastcancer.html, url:https\\://www.genome.gov/Genetic-Disorders/Breast-Cancer]" }, { "answer": "thoracic disease", "description": "A disease of anatomical entity that is located_in the thoracic cavity. [url:http\\://en.wikipedia.org/wiki/Thoracic_cavity]" }, { "answer": "thoracic cancer", "description": "An organ system cancer located_in the thoracic cavity that develops in the different types of cells within the lungs, as well as less common cancers of the esophagus, the trachea, or the chest wall. [url:https\\://radonc.ucsf.edu/thoracic-cancers]" }, { "answer": "oral squamous cell carcinoma", "description": "An oral cavity cancer that has_material_basis_in squamous cells. [url:http\\://en.wikipedia.org/wiki/Squamous-cell_carcinoma]" } ], "type": "one-hop" }, { "question": "Can you identify diseases that the protein Q86XW9 is associated with?", "source": "Q86XW9", "entities": { "protein": "Q86XW9" }, "answer": [ { "answer": "cancer", "description": "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis. [url:http\\://en.wikipedia.org/wiki/cancer, url:http\\://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=cancer]" }, { "answer": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum. [url:http\\://www.cancer.gov/dictionary?CdrID=444983]" }, { "answer": "large intestine cancer", "description": "An intestinal cancer that effects the long, tube-like organ that is connected to the small intestine at one end and the anus at the other. [url:http\\://en.wikipedia.org/wiki/Large_intestine]" }, { "answer": "embryoma", "description": "A carcinosarcoma and embryonal cancer that is located_in embryonic tissue and results_in a mass of rapidly growing cells. [url:http\\://en.wikipedia.org/wiki/Embryoma]" }, { "answer": "colon carcinoma", "description": "A colon cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. [url:http\\://en.wikipedia.org/wiki/Carcinoma]" }, { "answer": "colon cancer", "description": "A colorectal cancer that is located_in the colon. [url:http\\://www.cancer.gov/dictionary?CdrID=44237, url:https\\://www.genome.gov/Genetic-Disorders/Colon-Cancer]" } ], "type": "one-hop" }, { "question": "Can you list the diseases the protein P0DL12 is associated with?", "source": "P0DL12", "entities": { "protein": "P0DL12" }, "answer": [ { "answer": "muscular atrophy", "description": "muscular atrophy" }, { "answer": "autistic disorder", "description": "An autism spectrum disorder that is characterized by symptoms across all three symptom domains (communication, social, restricted repetitive interests and behaviors), delayed language development, and symptom onset prior to age 3 years. [url:http\\://en.wikipedia.org/wiki/Autism, url:http\\://www.neurodevnet.ca]" } ], "type": "one-hop" }, { "question": "Which diseases is the protein Q96A59 associated with?", "source": "Q96A59", "entities": { "protein": "Q96A59" }, "answer": [ { "answer": "lung carcinoma", "description": "A lung cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells and is located_in the lungs and has_symptom cough and has_symptom chest discomfort or pain and has_symptom weight loss and has_symptom hemoptysis. [url:https\\://merck.com/mmpe/sec05/ch062/ch062b.html]" }, { "answer": "lung adenocarcinoma", "description": "A lung non-small cell carcinoma that derives_from epithelial cells of glandular origin. [url:http\\://cancergenome.nih.gov/cancersselected/lungadenocarcinoma, url:http\\://en.wikipedia.org/wiki/Adenocarcinoma, url:http\\://en.wikipedia.org/wiki/Adenocarcinoma_of_the_lung]" }, { "answer": "lung cancer", "description": "A respiratory system cancer that is located_in the lung. [url:http\\://en.wikipedia.org/wiki/Lung_cancer]" }, { "answer": "pancreatic cancer", "description": "An endocrine gland cancer located_in the pancreas. [url:http\\://en.wikipedia.org/wiki/Pancreatic]" }, { "answer": "pancreatic carcinoma", "description": "A pancreas cancer that derives_from epithelial cells located_in the exocrine pancreas. [url:http\\://en.wikipedia.org/wiki/Carcinoma, url:http\\://www.cancer.gov/cancertopics/types/pancreatic]" } ], "type": "one-hop" }, { "question": "Could you please specify which diseases the protein A8MW95 is associated with?", "source": "A8MW95", "entities": { "protein": "A8MW95" }, "answer": [ { "answer": "embryoma", "description": "A carcinosarcoma and embryonal cancer that is located_in embryonic tissue and results_in a mass of rapidly growing cells. [url:http\\://en.wikipedia.org/wiki/Embryoma]" }, { "answer": "Kaposi's sarcoma", "description": "A connective tissue cancer that derives_from lymphatic endothelium, and derives_from spindle cells, results_in_formation_of vascular channels that fill with blood cells, has_material_basis_in Human herpesvirus 8 (HHV8). [url:http\\://cancerres.aacrjournals.org/content/58/8/1599.full.pdf, url:http\\://en.wikipedia.org/wiki/Kaposi%27s_sarcoma]" }, { "answer": "cancer", "description": "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis. [url:http\\://en.wikipedia.org/wiki/cancer, url:http\\://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=cancer]" }, { "answer": "obesity", "description": "An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness. [url:https\\://en.wikipedia.org/wiki/Obesity]" } ], "type": "one-hop" }, { "question": "What are the diseases that the protein O43687 is associated with?", "source": "O43687", "entities": { "protein": "O43687" }, "answer": [ { "answer": "substance-related disorder", "description": "A disease of mental health involving the abuse or dependence on a substance that is ingested in order to produce a high, alter one's senses, or otherwise affect functioning. [url:https\\://www.psychologytoday.com/us/conditions/substance-related-disorders]" }, { "answer": "substance abuse", "description": "A substance-related disorder that involves a maladaptive pattern of substance use leading to significant impairment in functioning. [url:http\\://allpsych.com/disorders/substance/substanceabuse.html, url:http\\://en.wikipedia.org/wiki/Substance_abuse]" } ], "type": "one-hop" }, { "question": "Can you identify diseases that the protein A6NMS3 is associated with?", "source": "A6NMS3", "entities": { "protein": "A6NMS3" }, "answer": [ { "answer": "anemia", "description": "A hematopoietic system disease that is characterized by a decrease in the normal number of red blood cells. [url:http\\://en.wikipedia.org/wiki/Anemia, url:http\\://www.nhlbi.nih.gov/health/health-topics/topics/anemia/]" }, { "answer": "oligoasthenoteratozoospermia", "description": "A form of male infertility that is characterized by a combination of low number or oligozoospermia, poor motility or asthenozoospermia, and abnormal shape or teratozoospermia of sperms. OAT is the most common cause of male subfertility. [url:https\\://en.wiktionary.org/wiki/oligoasthenoteratozoospermia, url:https\\://www.ncbi.nlm.nih.gov/pubmed/23628110, url:https\\://www.ncbi.nlm.nih.gov/pubmed/25781171]" }, { "answer": "male infertility", "description": "male infertility" }, { "answer": "primary ovarian insufficiency", "description": "An ovarian disease where ovaries do not produce estrogen despite high levels of circulating gonadotropins in women under 40. [url:http\\://en.wikipedia.org/wiki/Premature_ovarian_failure, url:https\\://pubmed.ncbi.nlm.nih.gov/27861765/, url:https\\://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477642/]" }, { "answer": "Fanconi anemia", "description": "A congenital hypoplastic anemia characterized by progressive pancytopenia with bone marrow failure, variable congenital malformations and predisposition to develop hematological or solid tumors. It is a result of a genetic defect in a cluster of proteins responsible for DNA repair. [url:http\\://en.wikipedia.org/wiki/Fanconi_anemia, url:http\\://ghr.nlm.nih.gov/condition/fanconi-anemia, url:http\\://rarediseases.info.nih.gov/gard/6425/fanconi-anemia/resources/1]" }, { "answer": "physical disorder", "description": "A disease that has_material_basis_in a genetic abnormality, error with embryonic development, infection or compromised intrauterine environment. [url:http\\://en.wikipedia.org/wiki/Congenital_disorder]" }, { "answer": "aplastic anemia", "description": "An anemia that is characterized by a deficiency of red blood cells, white blood cells and platelets produced by bone marrow. [url:http\\://en.wikipedia.org/wiki/Aplastic_anemia, url:http\\://www.nhlbi.nih.gov/health/health-topics/topics/aplastic/]" }, { "answer": "congenital hypoplastic anemia", "description": "congenital hypoplastic anemia" } ], "type": "one-hop" }, { "question": "Can you list the diseases the protein O14604 is associated with?", "source": "O14604", "entities": { "protein": "O14604" }, "answer": [ { "answer": "male breast cancer", "description": "A breast cancer that occurs in males. [url:https\\://www.ncbi.nlm.nih.gov/pubmed/24131976]" }, { "answer": "cancer", "description": "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis. [url:http\\://en.wikipedia.org/wiki/cancer, url:http\\://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=cancer]" } ], "type": "one-hop" }, { "question": "Which diseases is the protein Q8N5N4 associated with?", "source": "Q8N5N4", "entities": { "protein": "Q8N5N4" }, "answer": [ { "answer": "COVID-19", "description": "A Coronavirus infectious disease that is characterized by fever, cough and shortness of breath and that has_material_basis_in SARS-CoV-2. [url:https\\://www.cdc.gov/coronavirus/2019-ncov/about/index.html, url:https\\://www.ncbi.nlm.nih.gov/pubmed/?term=32007143, url:https\\://www.ncbi.nlm.nih.gov/pubmed/?term=32007145, url:https\\://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=2697049, url:https\\://www.who.int/emergencies/diseases/novel-coronavirus-2019]" }, { "answer": "cognitive disorder", "description": "A disease of mental health that affects cognitive functions including memory processing, perception and problem solving. [url:http\\://en.wikipedia.org/wiki/Cognitive_disorder]" }, { "answer": "psychotic disorder", "description": "A cognitive disorder that involves abnormal thinking and perceptions resulting in a disconnection with reality. [url:http\\://www.nlm.nih.gov/medlineplus/psychoticdisorders.html]" }, { "answer": "schizophrenia", "description": "A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness. [url:http\\://en.wikipedia.org/wiki/Schizophrenia]" }, { "answer": "Coronavirus infectious disease", "description": "A viral infectious disease that has_material_basis_in Coronavirus. [url:https\\://www.cdc.gov/coronavirus/, url:https\\://www.ncbi.nlm.nih.gov/books/NBK7782/, url:https\\://www.who.int/health-topics/coronavirus]" } ], "type": "one-hop" }, { "question": "Could you please specify which diseases the protein B4DU55 is associated with?", "source": "B4DU55", "entities": { "protein": "B4DU55" }, "answer": [ { "answer": "kidney disease", "description": "A urinary system disease that is located_in the kidney. [url:http\\://www.nlm.nih.gov/medlineplus/kidneydiseases.html]" } ], "type": "one-hop" }, { "question": "What are the diseases that the protein A6NCV1 is associated with?", "source": "A6NCV1", "entities": { "protein": "A6NCV1" }, "answer": [ { "answer": "synovitis", "description": "A connective tissue disease that results_in inflammation located_in synovial membrane that lines a synovial joint which causes pain and swelling. [url:https\\://en.wikipedia.org/wiki/Synovitis]" }, { "answer": "endometrial carcinoma", "description": "A endometrial cancer that is located_in the tissue lining the uterus. [url:http\\://www.cancer.gov/cancertopics/types/endometrial]" }, { "answer": "amyloidosis", "description": "A disease of metabolsism that is characterized by extracellular tissue deposition of mis-folded amyloid fibrils built up by twisted protofilaments, deposited in the spaces between the cells of vital organs, causing disruption of organ tissue structure and function. These deposits may result in a wide range of clinical manifestations depending upon their type, location, and the amount of deposition. [url:https\\://en.wikipedia.org/wiki/Amyloidosis, url:https\\://pubmed.ncbi.nlm.nih.gov/33100054/, url:https\\://pubmed.ncbi.nlm.nih.gov/33787033/, url:https\\://www.tandfonline.com/doi/pdf/10.1080/13506129.2020.1835263?needAccess=true]" } ], "type": "one-hop" }, { "question": "What are the known molecular functions is the protein P30050 associated with?", "source": "P30050", "entities": { "protein": "P30050" }, "answer": [ { "answer": "structural constituent of ribosome", "description": "The action of a molecule that contributes to the structural integrity of the ribosome. [GOC:mah]" }, { "answer": "RNA binding", "description": "Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah]" }, { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" }, { "answer": "large ribosomal subunit rRNA binding", "description": "Binding to large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA. [GOC:elh]" } ], "type": "one-hop" }, { "question": "What molecular functions is the protein Q9NTN9 associated with?", "source": "Q9NTN9", "entities": { "protein": "Q9NTN9" }, "answer": [ { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" }, { "answer": "chemorepellent activity", "description": "Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal. [GOC:ai]" }, { "answer": "semaphorin receptor binding", "description": "Binding to a semaphorin receptor. [GOC:ceb, PMID:12001990]" } ], "type": "one-hop" }, { "question": "Can you specify the molecular functions that the protein Q96S44 is associated with?", "source": "Q96S44", "entities": { "protein": "Q96S44" }, "answer": [ { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" }, { "answer": "p53 binding", "description": "Binding to one of the p53 family of proteins. [GOC:hjd]" }, { "answer": "hydrolase activity", "description": "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. [ISBN:0198506732]" }, { "answer": "ATP binding", "description": "Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]" }, { "answer": "protein serine/threonine kinase activity", "description": "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]" }, { "answer": "protein serine kinase activity", "description": "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. [RHEA:17989]" } ], "type": "one-hop" }, { "question": "Which specific molecular functions is the protein P15848 associated with?", "source": "P15848", "entities": { "protein": "P15848" }, "answer": [ { "answer": "metal ion binding", "description": "Binding to a metal ion. [GOC:ai]" }, { "answer": "arylsulfatase activity", "description": "Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate. [EC:3.1.6.1]" }, { "answer": "N-acetylgalactosamine-4-sulfatase activity", "description": "Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate. [EC:3.1.6.12]" } ], "type": "one-hop" }, { "question": "Could you tell me what molecular functions is the protein P42658 associated with?", "source": "P42658", "entities": { "protein": "P42658" }, "answer": [ { "answer": "potassium channel regulator activity", "description": "Binds to and modulates the activity of a potassium channel. [GOC:dos, GOC:mah]" }, { "answer": "serine-type peptidase activity", "description": "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]" }, { "answer": "dipeptidyl-peptidase activity", "description": "Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain. [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE]" } ], "type": "one-hop" }, { "question": "What are the known molecular functions is the protein Q14626 associated with?", "source": "Q14626", "entities": { "protein": "Q14626" }, "answer": [ { "answer": "transmembrane signaling receptor activity", "description": "Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. [GOC:go_curators, Wikipedia:Transmembrane_receptor]" }, { "answer": "interleukin-11 receptor activity", "description": "Combining with interleukin-11 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]" }, { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" }, { "answer": "interleukin-11 binding", "description": "Binding to interleukin-11. [GOC:jl]" } ], "type": "one-hop" }, { "question": "What molecular functions is the protein Q9H9Y2 associated with?", "source": "Q9H9Y2", "entities": { "protein": "Q9H9Y2" }, "answer": [ { "answer": "RNA binding", "description": "Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah]" }, { "answer": "rRNA primary transcript binding", "description": "Binding to an unprocessed ribosomal RNA transcript. [GOC:jl]" }, { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" } ], "type": "one-hop" }, { "question": "Can you specify the molecular functions that the protein P55854 is associated with?", "source": "P55854", "entities": { "protein": "P55854" }, "answer": [ { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" }, { "answer": "protein tag activity", "description": "A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation. [GOC:dos, PMID:19028679, PMID:20054389, PMID:6305978]" }, { "answer": "ubiquitin-like protein ligase binding", "description": "Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase. [GOC:jl]" } ], "type": "one-hop" }, { "question": "Which specific molecular functions is the protein Q96L91 associated with?", "source": "Q96L91", "entities": { "protein": "Q96L91" }, "answer": [ { "answer": "ATP-dependent chromatin remodeler activity", "description": "An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling. [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]" }, { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" }, { "answer": "chromatin binding", "description": "Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. [GOC:jl, ISBN:0198506732, PMID:20404130]" }, { "answer": "protein antigen binding", "description": "Binding to a protein antigen. [PMID:9360996]" }, { "answer": "hydrolase activity", "description": "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. [ISBN:0198506732]" }, { "answer": "DNA binding", "description": "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw]" }, { "answer": "helicase activity", "description": "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. [GOC:jl]" }, { "answer": "ATP binding", "description": "Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]" } ], "type": "one-hop" }, { "question": "Could you tell me what molecular functions is the protein Q9NWU1 associated with?", "source": "Q9NWU1", "entities": { "protein": "Q9NWU1" }, "answer": [ { "answer": "3-oxoacyl-[acyl-carrier-protein] synthase activity", "description": "Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]. [RHEA:22836]" } ], "type": "one-hop" }, { "question": "What are the known molecular functions is the protein Q9BZF1 associated with?", "source": "Q9BZF1", "entities": { "protein": "Q9BZF1" }, "answer": [ { "answer": "cholesterol binding", "description": "Binding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:jl, ISBN:0198506732]" }, { "answer": "phospholipid transporter activity", "description": "Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester. [GOC:ai, ISBN:0198506732]" }, { "answer": "phosphatidylserine transfer activity", "description": "Removes phosphatidylserine from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane. [PMID:26206935]" }, { "answer": "phosphatidylserine binding", "description": "Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine. [ISBN:0198506732, PMID:12000961]" }, { "answer": "phosphatidylinositol-4-phosphate binding", "description": "Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position. [GOC:bf, GOC:mah]" }, { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" } ], "type": "one-hop" }, { "question": "What molecular functions is the protein Q9Y4I1 associated with?", "source": "Q9Y4I1", "entities": { "protein": "Q9Y4I1" }, "answer": [ { "answer": "microfilament motor activity", "description": "A motor activity that generates movement along a microfilament, driven by ATP hydrolysis. [PMID:29716949]" }, { "answer": "ATP binding", "description": "Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]" }, { "answer": "calmodulin binding", "description": "Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. [GOC:krc]" }, { "answer": "RNA binding", "description": "Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah]" }, { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" }, { "answer": "actin filament binding", "description": "Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. [ISBN:0198506732]" }, { "answer": "small GTPase binding", "description": "Binding to a small monomeric GTPase. [GOC:mah, PMID:27218782]" } ], "type": "one-hop" }, { "question": "Can you specify the molecular functions that the protein P02788 is associated with?", "source": "P02788", "entities": { "protein": "P02788" }, "answer": [ { "answer": "serine-type endopeptidase activity", "description": "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]" }, { "answer": "lipopolysaccharide binding", "description": "Binding to a lipopolysaccharide. [PMID:11079463]" }, { "answer": "cysteine-type endopeptidase inhibitor activity", "description": "Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase. [GOC:dph, GOC:tb]" }, { "answer": "membrane destabilizing activity", "description": "Binding to a membrane and increasing its permeability. This may lead to cell membrane lysis and cell content release. [PMID:34496967]" }, { "answer": "protein serine/threonine kinase activator activity", "description": "Binds to and increases the activity of a protein serine/threonine kinase. [GOC:go_curators]" }, { "answer": "DNA binding", "description": "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw]" }, { "answer": "iron ion binding", "description": "Binding to an iron (Fe) ion. [GOC:ai]" }, { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" }, { "answer": "heparin binding", "description": "Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. [GOC:jl, ISBN:0198506732]" } ], "type": "one-hop" }, { "question": "Which specific molecular functions is the protein Q7Z3K3 associated with?", "source": "Q7Z3K3", "entities": { "protein": "Q7Z3K3" }, "answer": [ { "answer": "DNA binding", "description": "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw]" }, { "answer": "metal ion binding", "description": "Binding to a metal ion. [GOC:ai]" }, { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" } ], "type": "one-hop" }, { "question": "Could you tell me what molecular functions is the protein Q8IV03 associated with?", "source": "Q8IV03", "entities": { "protein": "Q8IV03" }, "answer": [ { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" } ], "type": "one-hop" }, { "question": "What are the known molecular functions is the protein O95843 associated with?", "source": "O95843", "entities": { "protein": "O95843" }, "answer": [ { "answer": "calcium ion binding", "description": "Binding to a calcium ion (Ca2+). [GOC:ai]" }, { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" }, { "answer": "calcium sensitive guanylate cyclase activator activity", "description": "Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration. [GOC:mah]" } ], "type": "one-hop" }, { "question": "What molecular functions is the protein Q7L9L4 associated with?", "source": "Q7L9L4", "entities": { "protein": "Q7L9L4" }, "answer": [ { "answer": "kinase activator activity", "description": "Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. [GOC:ai]" }, { "answer": "protein kinase activator activity", "description": "Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein. [GOC:ai]" }, { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" }, { "answer": "kinase binding", "description": "Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group. [GOC:jl]" }, { "answer": "metal ion binding", "description": "Binding to a metal ion. [GOC:ai]" } ], "type": "one-hop" }, { "question": "Can you specify the molecular functions that the protein Q9NVP2 is associated with?", "source": "Q9NVP2", "entities": { "protein": "Q9NVP2" }, "answer": [ { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" }, { "answer": "histone chaperone activity", "description": "Binding to and carrying a histone or a histone complex to unload or deposit it as a nucleosome. The histone can be newly synthesized or result from nucleosome disassembly (either spontaneously, or by a histone chaperone). [PMID:26459557]" }, { "answer": "histone binding", "description": "Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]" } ], "type": "one-hop" }, { "question": "Which specific molecular functions is the protein Q8IWV7 associated with?", "source": "Q8IWV7", "entities": { "protein": "Q8IWV7" }, "answer": [ { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" }, { "answer": "zinc ion binding", "description": "Binding to a zinc ion (Zn). [GOC:ai]" }, { "answer": "L-leucine binding", "description": "Binding to L-leucine, 2-amino-4-methylpentanoic acid. [GOC:BHF, GOC:mah]" }, { "answer": "ubiquitin protein ligase activity", "description": "Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues. [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]" } ], "type": "one-hop" }, { "question": "Could you tell me what molecular functions is the protein Q5I0X7 associated with?", "source": "Q5I0X7", "entities": { "protein": "Q5I0X7" }, "answer": [ { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" } ], "type": "one-hop" }, { "question": "What are the known molecular functions is the protein A8MWA4 associated with?", "source": "A8MWA4", "entities": { "protein": "A8MWA4" }, "answer": [ { "answer": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "description": "Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II. [GOC:txnOH]" }, { "answer": "metal ion binding", "description": "Binding to a metal ion. [GOC:ai]" }, { "answer": "DNA-binding transcription factor activity, RNA polymerase II-specific", "description": "A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. [GOC:txnOH-2018]" } ], "type": "one-hop" }, { "question": "What molecular functions is the protein Q9BTV4 associated with?", "source": "Q9BTV4", "entities": { "protein": "Q9BTV4" }, "answer": [ { "answer": "identical protein binding", "description": "Binding to an identical protein or proteins. [GOC:jl]" }, { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" } ], "type": "one-hop" }, { "question": "Can you specify the molecular functions that the protein P53007 is associated with?", "source": "P53007", "entities": { "protein": "P53007" }, "answer": [ { "answer": "citrate secondary active transmembrane transporter activity", "description": "Enables the transfer of citrate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. [GOC:mah, GOC:mtg_transport, GOC:vw]" }, { "answer": "citrate transmembrane transporter activity", "description": "Enables the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of a membrane to the other. [GOC:ai, RHEA:33183]" }, { "answer": "tricarboxylic acid transmembrane transporter activity", "description": "Enables the transfer of tricarboxylic acids from one side of a membrane to the other. Tricarboxylic acid are organic acids with three COOH groups. [GOC:ai]" }, { "answer": "antiporter activity", "description": "Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]" } ], "type": "one-hop" }, { "question": "Which specific molecular functions is the protein P52179 associated with?", "source": "P52179", "entities": { "protein": "P52179" }, "answer": [ { "answer": "kinase binding", "description": "Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group. [GOC:jl]" }, { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" }, { "answer": "structural constituent of muscle", "description": "The action of a molecule that contributes to the structural integrity of a muscle fiber. [GOC:mah]" }, { "answer": "protein homodimerization activity", "description": "Binding to an identical protein to form a homodimer. [GOC:jl]" }, { "answer": "identical protein binding", "description": "Binding to an identical protein or proteins. [GOC:jl]" } ], "type": "one-hop" }, { "question": "Could you tell me what molecular functions is the protein P82673 associated with?", "source": "P82673", "entities": { "protein": "P82673" }, "answer": [ { "answer": "structural constituent of ribosome", "description": "The action of a molecule that contributes to the structural integrity of the ribosome. [GOC:mah]" }, { "answer": "RNA binding", "description": "Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah]" } ], "type": "one-hop" }, { "question": "What are the known molecular functions is the protein O76099 associated with?", "source": "O76099", "entities": { "protein": "O76099" }, "answer": [ { "answer": "olfactory receptor activity", "description": "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell. [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]" }, { "answer": "G protein-coupled receptor activity", "description": "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]" } ], "type": "one-hop" }, { "question": "What molecular functions is the protein Q9WJR5 associated with?", "source": "Q9WJR5", "entities": { "protein": "Q9WJR5" }, "answer": [ { "answer": "RNA-directed DNA polymerase activity", "description": "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. [EC:2.7.7.49]" }, { "answer": "RNA stem-loop binding", "description": "Binding to a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop. [GOC:sart, PMID:16568238, PMID:20455544]" }, { "answer": "RNA-DNA hybrid ribonuclease activity", "description": "Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters. [EC:3.1.26.4]" }, { "answer": "zinc ion binding", "description": "Binding to a zinc ion (Zn). [GOC:ai]" }, { "answer": "DNA binding", "description": "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw]" } ], "type": "one-hop" }, { "question": "Can you specify the molecular functions that the protein Q92784 is associated with?", "source": "Q92784", "entities": { "protein": "Q92784" }, "answer": [ { "answer": "zinc ion binding", "description": "Binding to a zinc ion (Zn). [GOC:ai]" } ], "type": "one-hop" }, { "question": "Which specific molecular functions is the protein Q9H1M4 associated with?", "source": "Q9H1M4", "entities": { "protein": "Q9H1M4" }, "answer": [ { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" } ], "type": "one-hop" }, { "question": "Could you tell me what molecular functions is the protein Q96GM1 associated with?", "source": "Q96GM1", "entities": { "protein": "Q96GM1" }, "answer": [ { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" }, { "answer": "phosphatidate phosphatase activity", "description": "Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate. [GOC:pr, PMID:25814022, RHEA:27429]" } ], "type": "one-hop" }, { "question": "What are the known molecular functions is the protein Q7Z7J9 associated with?", "source": "Q7Z7J9", "entities": { "protein": "Q7Z7J9" }, "answer": [ { "answer": "protein kinase binding", "description": "Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl]" }, { "answer": "calcium-dependent protein kinase inhibitor activity", "description": "Binds to and stops, prevents or reduces the activity of a calcium-dependent protein kinase. [GOC:mah]" } ], "type": "one-hop" }, { "question": "What molecular functions is the protein Q8N752 associated with?", "source": "Q8N752", "entities": { "protein": "Q8N752" }, "answer": [ { "answer": "protein serine/threonine kinase activity", "description": "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]" }, { "answer": "protein serine kinase activity", "description": "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. [RHEA:17989]" }, { "answer": "ATP binding", "description": "Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]" } ], "type": "one-hop" }, { "question": "Can you specify the molecular functions that the protein Q9BXS5 is associated with?", "source": "Q9BXS5", "entities": { "protein": "Q9BXS5" }, "answer": [ { "answer": "clathrin adaptor activity", "description": "Bringing together a cargo protein with clathrin, responsible for the formation of endocytic vesicles. [GOC:BHF, PMID:15728179]" }, { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" } ], "type": "one-hop" }, { "question": "Which specific molecular functions is the protein Q8TAK5 associated with?", "source": "Q8TAK5", "entities": { "protein": "Q8TAK5" }, "answer": [ { "answer": "transcription cis-regulatory region binding", "description": "Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. [GOC:txnOH]" }, { "answer": "identical protein binding", "description": "Binding to an identical protein or proteins. [GOC:jl]" }, { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" } ], "type": "one-hop" }, { "question": "Could you tell me what molecular functions is the protein Q14697 associated with?", "source": "Q14697", "entities": { "protein": "Q14697" }, "answer": [ { "answer": "alpha-glucosidase activity", "description": "Catalysis of the hydrolysis of terminal, non-reducing alpha-linked alpha-D-glucose residue with release of alpha-D-glucose. [GOC:tb]" }, { "answer": "glucan 1,3-alpha-glucosidase activity", "description": "Catalysis of the hydrolysis of terminal (1->3)-alpha-D-glucosidic links in 1,3-alpha-D-glucans. [EC:3.2.1.84]" }, { "answer": "carbohydrate binding", "description": "Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. [GOC:mah]" }, { "answer": "RNA binding", "description": "Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah]" }, { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" } ], "type": "one-hop" }, { "question": "What are the known molecular functions is the protein Q92845 associated with?", "source": "Q92845", "entities": { "protein": "Q92845" }, "answer": [ { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" }, { "answer": "protein phosphatase binding", "description": "Binding to a protein phosphatase. [GOC:jl]" }, { "answer": "kinesin binding", "description": "Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation. [GOC:curators, PMID:8606779]" }, { "answer": "intraciliary transport particle B binding", "description": "Binding to an intraciliary transport particle B (IFT B) complex. [PMID:20889716]" } ], "type": "one-hop" }, { "question": "What molecular functions is the protein A6NMB9 associated with?", "source": "A6NMB9", "entities": { "protein": "A6NMB9" }, "answer": [ { "answer": "microtubule severing ATPase activity", "description": "Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP. [PMID:10910766]" }, { "answer": "ATP hydrolysis activity", "description": "Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. [RHEA:13065]" }, { "answer": "ATP binding", "description": "Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]" } ], "type": "one-hop" }, { "question": "Can you specify the molecular functions that the protein Q9H7R5 is associated with?", "source": "Q9H7R5", "entities": { "protein": "Q9H7R5" }, "answer": [ { "answer": "DNA-binding transcription factor activity, RNA polymerase II-specific", "description": "A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. [GOC:txnOH-2018]" }, { "answer": "metal ion binding", "description": "Binding to a metal ion. [GOC:ai]" }, { "answer": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "description": "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. [GOC:txnOH-2018]" } ], "type": "one-hop" }, { "question": "Which specific molecular functions is the protein A6NJY1 associated with?", "source": "A6NJY1", "entities": { "protein": "A6NJY1" }, "answer": [ { "answer": "antiporter activity", "description": "Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]" } ], "type": "one-hop" }, { "question": "Could you tell me what molecular functions is the protein Q9Y2K7 associated with?", "source": "Q9Y2K7", "entities": { "protein": "Q9Y2K7" }, "answer": [ { "answer": "unmethylated CpG binding", "description": "Binding to uan nmethylated CpG motif. Unmethylated CpG dinucleotides are often associated with gene promoters. [GOC:ai, PMID:10688657]" }, { "answer": "histone H3K36 demethylase activity", "description": "Catalysis of the removal of a methyl group from a modified lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. [PMID:16362057]" }, { "answer": "histone demethylase activity", "description": "Catalysis of the removal of a methyl group from a histone. [GOC:mah]" }, { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" }, { "answer": "histone H3K36me/H3K36me2 demethylase activity", "description": "Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. [PMID:20531378]" }, { "answer": "zinc ion binding", "description": "Binding to a zinc ion (Zn). [GOC:ai]" }, { "answer": "transcription coregulator activity", "description": "A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator]" } ], "type": "one-hop" }, { "question": "What are the known molecular functions is the protein Q9NQA5 associated with?", "source": "Q9NQA5", "entities": { "protein": "Q9NQA5" }, "answer": [ { "answer": "metal ion binding", "description": "Binding to a metal ion. [GOC:ai]" }, { "answer": "calcium channel activity", "description": "Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:mtg_transport, GOC:pr, ISBN:0815340729]" }, { "answer": "calmodulin binding", "description": "Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. [GOC:krc]" }, { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" } ], "type": "one-hop" }, { "question": "I'm curious, which proteins does the protein Q9BRP0 act on?", "source": "Q9BRP0", "entities": { "protein": "Q9BRP0" }, "answer": [ { "answer": "Q13485", "name": "SMAD4" }, { "answer": "O14753", "name": "OVOL1" }, { "answer": "P37275", "name": "ZEB1" } ], "type": "one-hop" }, { "question": "What proteins does the protein Q7Z4N2 act on?", "source": "Q7Z4N2", "entities": { "protein": "Q7Z4N2" }, "answer": [ { "answer": "Q8NER1", "name": "TRPV1" } ], "type": "one-hop" }, { "question": "On which proteins does the protein P20916 act?", "source": "P20916", "entities": { "protein": "P20916" }, "answer": [ { "answer": "P61586", "name": "RHOA" }, { "answer": "A6NGQ3", "name": "OBSCN" } ], "type": "one-hop" }, { "question": "Could you identify the proteins that the protein Q9NZV6 acts on?", "source": "Q9NZV6", "entities": { "protein": "Q9NZV6" }, "answer": [ { "answer": "P10599", "name": "TXN" } ], "type": "one-hop" }, { "question": "Could you specify the proteins that are acted on by the protein O43704?", "source": "O43704", "entities": { "protein": "O43704" }, "answer": [ { "answer": "P14061", "name": "HSD17B1" }, { "answer": "Q92506", "name": "HSD17B8" } ], "type": "one-hop" }, { "question": "I'm curious, which proteins does the protein Q9H2X3 act on?", "source": "Q9H2X3", "entities": { "protein": "Q9H2X3" }, "answer": [ { "answer": "Q6UXB4", "name": "CLEC4G" }, { "answer": "P33241", "name": "LSP1" }, { "answer": "Q9NZN5", "name": "ARHGEF12" }, { "answer": "P61586", "name": "RHOA" }, { "answer": "Q9H4B4", "name": "PLK3" }, { "answer": "O00602", "name": "FCN1" }, { "answer": "Q8IVT5", "name": "KSR1" }, { "answer": "Q92752", "name": "TNR" } ], "type": "one-hop" }, { "question": "What proteins does the protein Q9UKM7 act on?", "source": "Q9UKM7", "entities": { "protein": "Q9UKM7" }, "answer": [ { "answer": "P26572", "name": "MGAT1" }, { "answer": "O43451", "name": "MGAM" }, { "answer": "Q2M2H8", "name": "MGAM2" }, { "answer": "Q9NR34", "name": "MAN1C1" } ], "type": "one-hop" }, { "question": "On which proteins does the protein O95907 act?", "source": "O95907", "entities": { "protein": "O95907" }, "answer": [ { "answer": "P35613", "name": "BSG" } ], "type": "one-hop" }, { "question": "Could you identify the proteins that the protein Q8IU68 acts on?", "source": "Q8IU68", "entities": { "protein": "Q8IU68" }, "answer": [ { "answer": "Q15628", "name": "TRADD" } ], "type": "one-hop" }, { "question": "Could you specify the proteins that are acted on by the protein Q8TAD8?", "source": "Q8TAD8", "entities": { "protein": "Q8TAD8" }, "answer": [ { "answer": "P84022", "name": "SMAD3" }, { "answer": "Q9NRR4", "name": "DROSHA" }, { "answer": "Q9Y388", "name": "RBMX2" }, { "answer": "Q13485", "name": "SMAD4" } ], "type": "one-hop" }, { "question": "I'm curious, which proteins does the protein Q9BZE3 act on?", "source": "Q9BZE3", "entities": { "protein": "Q9BZE3" }, "answer": [ { "answer": "P03372", "name": "ESR1" } ], "type": "one-hop" }, { "question": "What proteins does the protein Q9NYR9 act on?", "source": "Q9NYR9", "entities": { "protein": "Q9NYR9" }, "answer": [ { "answer": "Q15653", "name": "NFKBIB" }, { "answer": "Q00653", "name": "NFKB2" }, { "answer": "Q04206", "name": "RELA" } ], "type": "one-hop" }, { "question": "On which proteins does the protein Q9Y2E4 act?", "source": "Q9Y2E4", "entities": { "protein": "Q9Y2E4" }, "answer": [ { "answer": "Q86VU5", "name": "COMTD1" }, { "answer": "P21964", "name": "COMT" }, { "answer": "Q8IVS2", "name": "MCAT" }, { "answer": "P86397", "name": "HTD2" }, { "answer": "Q8WZ04", "name": "TOMT" }, { "answer": "P51659", "name": "HSD17B4" } ], "type": "one-hop" }, { "question": "Could you identify the proteins that the protein Q6IE81 acts on?", "source": "Q6IE81", "entities": { "protein": "Q6IE81" }, "answer": [ { "answer": "Q9HAF1", "name": "MEAF6" }, { "answer": "P35222", "name": "CTNNB1" }, { "answer": "O95251", "name": "KAT7" }, { "answer": "P62805", "name": "H4C1" }, { "answer": "Q8WYB5", "name": "KAT6B" }, { "answer": "Q9UNL4", "name": "ING4" }, { "answer": "Q92794", "name": "KAT6A" }, { "answer": "Q8WYH8", "name": "ING5" } ], "type": "one-hop" }, { "question": "Could you specify the proteins that are acted on by the protein Q92622?", "source": "Q92622", "entities": { "protein": "Q92622" }, "answer": [ { "answer": "Q96AH8", "name": "RAB7B" }, { "answer": "Q9P2Y5", "name": "UVRAG" }, { "answer": "Q99570", "name": "PIK3R4" }, { "answer": "Q14653", "name": "IRF3" }, { "answer": "Q14457", "name": "BECN1" } ], "type": "one-hop" }, { "question": "I'm curious, which proteins does the protein Q9UHE5 act on?", "source": "Q9UHE5", "entities": { "protein": "Q9UHE5" }, "answer": [ { "answer": "Q6N069", "name": "NAA16" }, { "answer": "Q9BXJ9", "name": "NAA15" }, { "answer": "Q9BSU3", "name": "NAA11" }, { "answer": "P61599", "name": "NAA20" }, { "answer": "P15144", "name": "ANPEP" }, { "answer": "Q9H7X0", "name": "NAA60" }, { "answer": "P41227", "name": "NAA10" }, { "answer": "Q9H8E8", "name": "KAT14" }, { "answer": "Q5VZE5", "name": "NAA35" }, { "answer": "P56817", "name": "BACE1" } ], "type": "one-hop" }, { "question": "What proteins does the protein Q8NGL0 act on?", "source": "Q8NGL0", "entities": { "protein": "Q8NGL0" }, "answer": [ { "answer": "Q00765", "name": "REEP5" }, { "answer": "O60262", "name": "GNG7" }, { "answer": "P62873", "name": "GNB1" }, { "answer": "P32121", "name": "ARRB2" }, { "answer": "P49407", "name": "ARRB1" }, { "answer": "Q9H902", "name": "REEP1" } ], "type": "one-hop" }, { "question": "On which proteins does the protein Q9H6B9 act?", "source": "Q9H6B9", "entities": { "protein": "Q9H6B9" }, "answer": [ { "answer": "Q6JQN1", "name": "ACAD10" }, { "answer": "P21549", "name": "AGXT" }, { "answer": "A1L0T0", "name": "ILVBL" } ], "type": "one-hop" }, { "question": "Could you identify the proteins that the protein Q9NWK9 acts on?", "source": "Q9NWK9", "entities": { "protein": "Q9NWK9" }, "answer": [ { "answer": "Q16594", "name": "TAF9" }, { "answer": "Q9Y3D8", "name": "AK6" }, { "answer": "Q9UHK0", "name": "NUFIP1" }, { "answer": "O00567", "name": "NOP56" } ], "type": "one-hop" }, { "question": "Could you specify the proteins that are acted on by the protein P38432?", "source": "P38432", "entities": { "protein": "P38432" }, "answer": [ { "answer": "P54253", "name": "ATXN1" }, { "answer": "O95602", "name": "POLR1A" }, { "answer": "P12956", "name": "XRCC6" }, { "answer": "Q14978", "name": "NOLC1" }, { "answer": "Q9UNA4", "name": "POLI" }, { "answer": "Q9BZL1", "name": "UBL5" }, { "answer": "Q9BUR4", "name": "WRAP53" }, { "answer": "Q8N2W9", "name": "PIAS4" } ], "type": "one-hop" }, { "question": "I'm curious, which proteins does the protein O00445 act on?", "source": "O00445", "entities": { "protein": "O00445" }, "answer": [ { "answer": "P61764", "name": "STXBP1" }, { "answer": "Q8IV08", "name": "PLD3" }, { "answer": "Q9NY47", "name": "CACNA2D2" }, { "answer": "P01308", "name": "INS" } ], "type": "one-hop" }, { "question": "What proteins does the protein P02808 act on?", "source": "P02808", "entities": { "protein": "P02808" }, "answer": [ { "answer": "P04637", "name": "TP53" }, { "answer": "Q12889", "name": "OVGP1" } ], "type": "one-hop" }, { "question": "On which proteins does the protein Q8WWM9 act?", "source": "Q8WWM9", "entities": { "protein": "Q8WWM9" }, "answer": [ { "answer": "P08582", "name": "MELTF" } ], "type": "one-hop" }, { "question": "Could you identify the proteins that the protein O00481 acts on?", "source": "O00481", "entities": { "protein": "O00481" }, "answer": [ { "answer": "O60437", "name": "PPL" } ], "type": "one-hop" }, { "question": "Could you specify the proteins that are acted on by the protein O00461?", "source": "O00461", "entities": { "protein": "O00461" }, "answer": [ { "answer": "P49641", "name": "MAN2A2" } ], "type": "one-hop" }, { "question": "I'm curious, which proteins does the protein Q96T52 act on?", "source": "Q96T52", "entities": { "protein": "Q96T52" }, "answer": [ { "answer": "P61009", "name": "SPCS3" }, { "answer": "Q9Y6A9", "name": "SPCS1" } ], "type": "one-hop" }, { "question": "What proteins does the protein P28347 act on?", "source": "P28347", "entities": { "protein": "P28347" }, "answer": [ { "answer": "Q15562", "name": "TEAD2" }, { "answer": "P46937", "name": "YAP1" }, { "answer": "Q96J02", "name": "ITCH" } ], "type": "one-hop" }, { "question": "On which proteins does the protein Q15650 act?", "source": "Q15650", "entities": { "protein": "Q15650" }, "answer": [ { "answer": "Q9HC98", "name": "NEK6" }, { "answer": "A2PYH4", "name": "HFM1" }, { "answer": "Q8N3C0", "name": "ASCC3" }, { "answer": "P10275", "name": "AR" }, { "answer": "Q9H1I8", "name": "ASCC2" }, { "answer": "P19793", "name": "RXRA" }, { "answer": "Q8N9N2", "name": "ASCC1" }, { "answer": "Q9P0M2", "name": "AKAP7" } ], "type": "one-hop" }, { "question": "Could you identify the proteins that the protein P51687 acts on?", "source": "P51687", "entities": { "protein": "P51687" }, "answer": [ { "answer": "Q6BCY4", "name": "CYB5R2" }, { "answer": "Q16762", "name": "TST" }, { "answer": "Q6IPT4", "name": "CYB5RL" }, { "answer": "O95340", "name": "PAPSS2" }, { "answer": "P25325", "name": "MPST" } ], "type": "one-hop" }, { "question": "Could you specify the proteins that are acted on by the protein Q6ZS30?", "source": "Q6ZS30", "entities": { "protein": "Q6ZS30" }, "answer": [ { "answer": "Q9NRD8", "name": "DUOX2" }, { "answer": "P01112", "name": "HRAS" } ], "type": "one-hop" }, { "question": "I'm curious, which proteins does the protein O43772 act on?", "source": "O43772", "entities": { "protein": "O43772" }, "answer": [ { "answer": "Q07869", "name": "PPARA" }, { "answer": "Q8N8R3", "name": "SLC25A29" } ], "type": "one-hop" }, { "question": "What proteins does the protein Q9H093 act on?", "source": "Q9H093", "entities": { "protein": "Q9H093" }, "answer": [ { "answer": "O14974", "name": "PPP1R12A" } ], "type": "one-hop" }, { "question": "On which proteins does the protein Q9BY07 act?", "source": "Q9BY07", "entities": { "protein": "Q9BY07" }, "answer": [ { "answer": "Q9BXS9", "name": "SLC26A6" }, { "answer": "P40879", "name": "SLC26A3" } ], "type": "one-hop" }, { "question": "Could you identify the proteins that the protein Q8N239 acts on?", "source": "Q8N239", "entities": { "protein": "Q8N239" }, "answer": [ { "answer": "Q13617", "name": "CUL2" }, { "answer": "Q93034", "name": "CUL5" }, { "answer": "Q96AX9", "name": "MIB2" }, { "answer": "Q9NR09", "name": "BIRC6" } ], "type": "one-hop" }, { "question": "Could you specify the proteins that are acted on by the protein Q9Y5Z6?", "source": "Q9Y5Z6", "entities": { "protein": "Q9Y5Z6" }, "answer": [ { "answer": "Q99102", "name": "MUC4" }, { "answer": "Q10981", "name": "FUT2" }, { "answer": "Q9Y2C3", "name": "B3GALT5" } ], "type": "one-hop" }, { "question": "I'm curious, which proteins does the protein P50452 act on?", "source": "P50452", "entities": { "protein": "P50452" }, "answer": [ { "answer": "P05120", "name": "SERPINB2" } ], "type": "one-hop" }, { "question": "What proteins does the protein Q6P5Q4 act on?", "source": "Q6P5Q4", "entities": { "protein": "Q6P5Q4" }, "answer": [ { "answer": "Q8WZ42", "name": "TTN" }, { "answer": "P35609", "name": "ACTN2" }, { "answer": "Q14896", "name": "MYBPC3" }, { "answer": "Q08043", "name": "ACTN3" } ], "type": "one-hop" }, { "question": "On which proteins does the protein P29973 act?", "source": "P29973", "entities": { "protein": "P29973" }, "answer": [ { "answer": "A8MU46", "name": "SMTNL1" }, { "answer": "P35913", "name": "PDE6B" }, { "answer": "Q96GE6", "name": "CALML4" } ], "type": "one-hop" }, { "question": "Could you identify the proteins that the protein Q96RD1 acts on?", "source": "Q96RD1", "entities": { "protein": "Q96RD1" }, "answer": [ { "answer": "P62873", "name": "GNB1" }, { "answer": "O60262", "name": "GNG7" }, { "answer": "P32121", "name": "ARRB2" }, { "answer": "P49407", "name": "ARRB1" }, { "answer": "Q9H902", "name": "REEP1" } ], "type": "one-hop" }, { "question": "Could you specify the proteins that are acted on by the protein Q9UHQ9?", "source": "Q9UHQ9", "entities": { "protein": "Q9UHQ9" }, "answer": [ { "answer": "Q6P4F2", "name": "FDX2" }, { "answer": "P21912", "name": "SDHB" }, { "answer": "Q9P2R7", "name": "SUCLA2" }, { "answer": "Q6IPT4", "name": "CYB5RL" }, { "answer": "P51687", "name": "SUOX" }, { "answer": "Q16881", "name": "TXNRD1" }, { "answer": "Q12882", "name": "DPYD" }, { "answer": "P22570", "name": "FDXR" } ], "type": "one-hop" }, { "question": "I'm curious, which proteins does the protein Q5K4E3 act on?", "source": "Q5K4E3", "entities": { "protein": "Q5K4E3" }, "answer": [ { "answer": "P25116", "name": "F2R" }, { "answer": "O00254", "name": "F2RL2" } ], "type": "one-hop" }, { "question": "What proteins does the protein Q5W0V3 act on?", "source": "Q5W0V3", "entities": { "protein": "Q5W0V3" }, "answer": [ { "answer": "Q9H8T0", "name": "AKTIP" } ], "type": "one-hop" }, { "question": "On which proteins does the protein Q12923 act?", "source": "Q12923", "entities": { "protein": "Q12923" }, "answer": [ { "answer": "P07947", "name": "YES1" }, { "answer": "Q9HB19", "name": "PLEKHA2" }, { "answer": "P52943", "name": "CRIP2" }, { "answer": "Q8TC17", "name": "GRAPL" }, { "answer": "P42263", "name": "GRIA3" }, { "answer": "P07948", "name": "LYN" }, { "answer": "Q13308", "name": "PTK7" }, { "answer": "P08631", "name": "HCK" }, { "answer": "P42261", "name": "GRIA1" } ], "type": "one-hop" }, { "question": "Could you specify the proteins that are acted on by the protein Q92615?", "source": "Q92615", "entities": { "protein": "Q92615" }, "answer": [ { "answer": "P62945", "name": "RPL41" } ], "type": "one-hop" }, { "question": "I'm curious, which proteins does the protein A6NL08 act on?", "source": "A6NL08", "entities": { "protein": "A6NL08" }, "answer": [ { "answer": "P32121", "name": "ARRB2" }, { "answer": "O60262", "name": "GNG7" }, { "answer": "P62873", "name": "GNB1" }, { "answer": "P49407", "name": "ARRB1" }, { "answer": "Q9H902", "name": "REEP1" } ], "type": "one-hop" }, { "question": "What is the molecular function of the protein translated from the gene RND3?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "RND3", "name": "Rho family GTPase 3" }, "MidAttributes": { "id": "P61587", "name": "RND3" }, "answer": [ { "answer": "GTP binding", "description": "Binding to GTP, guanosine triphosphate. [GOC:ai]" }, { "answer": "GTPase activity", "description": "Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. [PMID:26832457, PMID:27218782]" }, { "answer": "protein kinase binding", "description": "Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl]" }, { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene EOLA1?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "EOLA1", "name": "endothelium and lymphocyte associated ASCH domain 1" }, "MidAttributes": { "id": "Q8TE69", "name": "EOLA1" }, "answer": [ { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene CSMD1?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "CSMD1", "name": "CUB and Sushi multiple domains 1" }, "MidAttributes": { "id": "Q96PZ7", "name": "CSMD1" }, "answer": [ { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene GOLT1A?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "GOLT1A", "name": "golgi transport 1A" }, "MidAttributes": { "id": "Q6ZVE7", "name": "GOLT1A" }, "answer": [ { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" }, { "answer": "molecular_function", "description": "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. [GOC:pdt]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene SIPA1L3?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "SIPA1L3", "name": "signal induced proliferation associated 1 like 3" }, "MidAttributes": { "id": "O60292", "name": "SIPA1L3" }, "answer": [ { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" }, { "answer": "GTPase activator activity", "description": "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. [GOC:mah]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene LRRC73?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "LRRC73", "name": "leucine rich repeat containing 73" }, "MidAttributes": { "id": "Q5JTD7", "name": "LRRC73" }, "answer": [ { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene MTO1?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "MTO1", "name": "mitochondrial tRNA translation optimization 1" }, "MidAttributes": { "id": "Q9Y2Z2", "name": "MTO1" }, "answer": [ { "answer": "flavin adenine dinucleotide binding", "description": "Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. [GOC:ai, GOC:imk, ISBN:0198506732]" }, { "answer": "RNA binding", "description": "Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene CXCL3?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "CXCL3", "name": "C-X-C motif chemokine ligand 3" }, "MidAttributes": { "id": "P19876", "name": "CXCL3" }, "answer": [ { "answer": "chemokine activity", "description": "The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. [GOC:BHF, GOC:rl, PMID:12183377, Wikipedia:Chemokine]" }, { "answer": "CXCR chemokine receptor binding", "description": "Binding to a chemokine receptor in the CXCR family. [GOC:ceb, PMID:11910892]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene FBXL6?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "FBXL6", "name": "F-box and leucine rich repeat protein 6" }, "MidAttributes": { "id": "Q8N531", "name": "FBXL6" }, "answer": [ { "answer": "ubiquitin-protein transferase activity", "description": "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. [GOC:BioGRID, GOC:jh2, PMID:9635407]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene CPD?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "CPD", "name": "carboxypeptidase D" }, "MidAttributes": { "id": "O75976", "name": "CPD" }, "answer": [ { "answer": "metallocarboxypeptidase activity", "description": "Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]" }, { "answer": "serine-type carboxypeptidase activity", "description": "Catalysis of the hydrolysis of a single C-terminal amino acid residue from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]" }, { "answer": "zinc ion binding", "description": "Binding to a zinc ion (Zn). [GOC:ai]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene ZNF552?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "ZNF552", "name": "zinc finger protein 552" }, "MidAttributes": { "id": "Q9H707", "name": "ZNF552" }, "answer": [ { "answer": "metal ion binding", "description": "Binding to a metal ion. [GOC:ai]" }, { "answer": "DNA-binding transcription factor activity, RNA polymerase II-specific", "description": "A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. [GOC:txnOH-2018]" }, { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" }, { "answer": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "description": "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. [GOC:txnOH-2018]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene ERBIN?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "ERBIN", "name": "erbb2 interacting protein" }, "MidAttributes": { "id": "Q96RT1", "name": "ERBIN" }, "answer": [ { "answer": "structural constituent of cytoskeleton", "description": "The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. [GOC:mah]" }, { "answer": "ErbB-2 class receptor binding", "description": "Binding to a protein-tyrosine kinase receptor Neu/ErbB-2/HER2. [GOC:jl]" }, { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" }, { "answer": "signaling receptor binding", "description": "Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:bf, GOC:ceb, ISBN:0198506732]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene STAG1?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "STAG1", "name": "STAG1 cohesin complex component" }, "MidAttributes": { "id": "Q8WVM7", "name": "STAG1" }, "answer": [ { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" }, { "answer": "chromatin binding", "description": "Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. [GOC:jl, ISBN:0198506732, PMID:20404130]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene PSMD3?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "PSMD3", "name": "proteasome 26S subunit, non-ATPase 3" }, "MidAttributes": { "id": "O43242", "name": "PSMD3" }, "answer": [ { "answer": "enzyme regulator activity", "description": "Binds to and modulates the activity of an enzyme. [GOC:dph, GOC:mah, GOC:tb]" }, { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene ORAI3?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "ORAI3", "name": "ORAI calcium release-activated calcium modulator 3" }, "MidAttributes": { "id": "Q9BRQ5", "name": "ORAI3" }, "answer": [ { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" }, { "answer": "store-operated calcium channel activity", "description": "A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores. [GOC:dph, GOC:tb, PMID:15788710]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene OR4F16?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "OR4F16", "name": "olfactory receptor family 4 subfamily F member 16" }, "MidAttributes": { "id": "Q6IEY1", "name": "OR4F3" }, "answer": [ { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" }, { "answer": "G protein-coupled receptor activity", "description": "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]" }, { "answer": "olfactory receptor activity", "description": "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell. [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene PRADC1?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "PRADC1", "name": "protease associated domain containing 1" }, "MidAttributes": { "id": "Q9BSG0", "name": "PRADC1" }, "answer": [ { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene FANCB?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "FANCB", "name": "FA complementation group B" }, "MidAttributes": { "id": "Q8NB91", "name": "FANCB" }, "answer": [ { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene OR3A3?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "OR3A3", "name": "olfactory receptor family 3 subfamily A member 3" }, "MidAttributes": { "id": "P47888", "name": "OR3A3" }, "answer": [ { "answer": "G protein-coupled receptor activity", "description": "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]" }, { "answer": "olfactory receptor activity", "description": "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell. [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene OR6X1?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "OR6X1", "name": "olfactory receptor family 6 subfamily X member 1" }, "MidAttributes": { "id": "Q8NH79", "name": "OR6X1" }, "answer": [ { "answer": "G protein-coupled receptor activity", "description": "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]" }, { "answer": "olfactory receptor activity", "description": "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell. [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene TLE4?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "TLE4", "name": "TLE family member 4, transcriptional corepressor" }, "MidAttributes": { "id": "Q04727", "name": "TLE4" }, "answer": [ { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" }, { "answer": "DNA-binding transcription factor binding", "description": "Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. [GOC:txnOH-2018]" }, { "answer": "transcription corepressor activity", "description": "A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. [GOC:txnOH-2018, PMID:10213677, PMID:16858867]" }, { "answer": "chromatin binding", "description": "Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. [GOC:jl, ISBN:0198506732, PMID:20404130]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene VSTM2L?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "VSTM2L", "name": "V-set and transmembrane domain containing 2 like" }, "MidAttributes": { "id": "Q96N03", "name": "VSTM2L" }, "answer": [ { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene RANBP17?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "RANBP17", "name": "RAN binding protein 17" }, "MidAttributes": { "id": "Q9H2T7", "name": "RANBP17" }, "answer": [ { "answer": "GTP binding", "description": "Binding to GTP, guanosine triphosphate. [GOC:ai]" }, { "answer": "small GTPase binding", "description": "Binding to a small monomeric GTPase. [GOC:mah, PMID:27218782]" }, { "answer": "nuclear export signal receptor activity", "description": "Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein. [GOC:bf, GOC:mah, GOC:pg, GOC:vw, PMID:11743003, PMID:25802992, PMID:28713609, Wikipedia:Nuclear_transport]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene C17orf67?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "C17orf67", "name": "chromosome 17 open reading frame 67" }, "MidAttributes": { "id": "Q0P5P2", "name": "C17orf67" }, "answer": [ { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene PCMTD1?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "PCMTD1", "name": "protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1" }, "MidAttributes": { "id": "Q96MG8", "name": "PCMTD1" }, "answer": [ { "answer": "ubiquitin-like ligase-substrate adaptor activity", "description": "The binding activity of a molecule that brings together a ubiquitin-like ligase (including ubiquitin ligase and UFM1 ligase) and its substrate. Usually mediated by F-box BTB/POZ domain proteins. [PMID:24658274]" }, { "answer": "protein-L-isoaspartate (D-aspartate) O-methyltransferase activity", "description": "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester. [EC:2.1.1.77]" }, { "answer": "S-adenosylmethionine-dependent methyltransferase activity", "description": "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. [GOC:mah]" }, { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene MFNG?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "MFNG", "name": "MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase" }, "MidAttributes": { "id": "O00587", "name": "MFNG" }, "answer": [ { "answer": "O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity", "description": "Catalysis of the transfer of a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor. [EC:2.4.1.222]" }, { "answer": "metal ion binding", "description": "Binding to a metal ion. [GOC:ai]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene UST?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "UST", "name": "uronyl 2-sulfotransferase" }, "MidAttributes": { "id": "Q9Y2C2", "name": "UST" }, "answer": [ { "answer": "sulfotransferase activity", "description": "Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. [GOC:curators]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene SDE2?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "SDE2", "name": "SDE2 telomere maintenance homolog" }, "MidAttributes": { "id": "Q6IQ49", "name": "SDE2" }, "answer": [ { "answer": "snoRNA binding", "description": "Binding to a small nucleolar RNA. [GOC:mah]" }, { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" }, { "answer": "damaged DNA binding", "description": "Binding to damaged DNA. [GOC:jl]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene SPATA22?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "SPATA22", "name": "spermatogenesis associated 22" }, "MidAttributes": { "id": "Q8NHS9", "name": "SPATA22" }, "answer": [ { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene WLS?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "WLS", "name": "Wnt ligand secretion mediator" }, "MidAttributes": { "id": "Q5T9L3", "name": "WLS" }, "answer": [ { "answer": "Wnt-protein binding", "description": "Binding to a Wnt-protein, a secreted growth factor involved in signaling. [GOC:jl]" }, { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene AIFM3?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "AIFM3", "name": "apoptosis inducing factor mitochondria associated 3" }, "MidAttributes": { "id": "Q96NN9", "name": "AIFM3" }, "answer": [ { "answer": "flavin adenine dinucleotide binding", "description": "Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. [GOC:ai, GOC:imk, ISBN:0198506732]" }, { "answer": "oxidoreductase activity, acting on NAD(P)H", "description": "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]" }, { "answer": "2 iron, 2 sulfur cluster binding", "description": "Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]" }, { "answer": "metal ion binding", "description": "Binding to a metal ion. [GOC:ai]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene PDCD1LG2?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "PDCD1LG2", "name": "programmed cell death 1 ligand 2" }, "MidAttributes": { "id": "Q9BQ51", "name": "PDCD1LG2" }, "answer": [ { "answer": "molecular_function", "description": "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. [GOC:pdt]" }, { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene TBCK?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "TBCK", "name": "TBC1 domain containing kinase" }, "MidAttributes": { "id": "Q8TEA7", "name": "TBCK" }, "answer": [ { "answer": "GTPase activator activity", "description": "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. [GOC:mah]" }, { "answer": "protein kinase activity", "description": "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. [PMID:25399640]" }, { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" }, { "answer": "ATP binding", "description": "Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene BNIP2?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "BNIP2", "name": "BCL2 interacting protein 2" }, "MidAttributes": { "id": "Q12982", "name": "BNIP2" }, "answer": [ { "answer": "GTPase activator activity", "description": "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. [GOC:mah]" }, { "answer": "calcium ion binding", "description": "Binding to a calcium ion (Ca2+). [GOC:ai]" }, { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene NANP?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "NANP", "name": "N-acetylneuraminic acid phosphatase" }, "MidAttributes": { "id": "Q8TBE9", "name": "NANP" }, "answer": [ { "answer": "N-acylneuraminate-9-phosphatase activity", "description": "Catalysis of the reaction: N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate. [EC:3.1.3.29, MetaCyc:N-ACYLNEURAMINATE-9-PHOSPHATASE-RXN]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene C11orf24?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "C11orf24", "name": "chromosome 11 open reading frame 24" }, "MidAttributes": { "id": "Q96F05", "name": "C11orf24" }, "answer": [ { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene ZNF33A?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "ZNF33A", "name": "zinc finger protein 33A" }, "MidAttributes": { "id": "Q06730", "name": "ZNF33A" }, "answer": [ { "answer": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "description": "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. [GOC:txnOH-2018]" }, { "answer": "metal ion binding", "description": "Binding to a metal ion. [GOC:ai]" }, { "answer": "DNA-binding transcription activator activity, RNA polymerase II-specific", "description": "A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859]" }, { "answer": "DNA-binding transcription factor activity", "description": "A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. [GOC:txnOH-2018]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene TOMM22?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "TOMM22", "name": "translocase of outer mitochondrial membrane 22" }, "MidAttributes": { "id": "Q9NS69", "name": "TOMM22" }, "answer": [ { "answer": "mitochondrion targeting sequence binding", "description": "Binding to a mitochondrion targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the mitochondrion. [GOC:mah]" }, { "answer": "protein transmembrane transporter activity", "description": "Enables the transfer of a protein from one side of a membrane to the other. [GOC:jl]" }, { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene OPN1SW?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "OPN1SW", "name": "opsin 1, short wave sensitive" }, "MidAttributes": { "id": "P03999", "name": "OPN1SW" }, "answer": [ { "answer": "signaling receptor activity", "description": "Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. [GOC:bf, GOC:signaling]" }, { "answer": "G protein-coupled photoreceptor activity", "description": "Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, GOC:dph, ISBN:0198506732]" }, { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene GJA9?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "GJA9", "name": "gap junction protein alpha 9" }, "MidAttributes": { "id": "P57773", "name": "GJA9" }, "answer": [ { "answer": "gap junction channel activity", "description": "A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes. [GOC:dgh, GOC:mtg_transport, ISBN:0815340729]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene DMRTC1B?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "DMRTC1B", "name": "DMRT like family C1B" }, "MidAttributes": { "id": "Q5HYR2", "name": "DMRTC1" }, "answer": [ { "answer": "DNA-binding transcription factor activity, RNA polymerase II-specific", "description": "A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. [GOC:txnOH-2018]" }, { "answer": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "description": "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. [GOC:txnOH-2018]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene VBP1?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "VBP1", "name": "VHL binding protein 1" }, "MidAttributes": { "id": "P61758", "name": "VBP1" }, "answer": [ { "answer": "amyloid-beta binding", "description": "Binding to an amyloid-beta peptide/protein. [GOC:hjd]" }, { "answer": "tubulin binding", "description": "Binding to monomeric or multimeric forms of tubulin, including microtubules. [GOC:clt]" }, { "answer": "unfolded protein binding", "description": "Binding to an unfolded protein. [GOC:ai]" }, { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene TRAPPC10?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "TRAPPC10", "name": "trafficking protein particle complex subunit 10" }, "MidAttributes": { "id": "P48553", "name": "TRAPPC10" }, "answer": [ { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene NOTCH2NLA?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "NOTCH2NLA", "name": "notch 2 N-terminal like A" }, "MidAttributes": { "id": "Q7Z3S9", "name": "NOTCH2NLA" }, "answer": [ { "answer": "Notch binding", "description": "Binding to a Notch (N) protein, a surface receptor. [GOC:ceb]" }, { "answer": "protein binding", "description": "Binding to a protein. [GOC:go_curators]" }, { "answer": "calcium ion binding", "description": "Binding to a calcium ion (Ca2+). [GOC:ai]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene TFB2M?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "TFB2M", "name": "transcription factor B2, mitochondrial" }, "MidAttributes": { "id": "Q9H5Q4", "name": "TFB2M" }, "answer": [ { "answer": "mitochondrial transcription factor activity", "description": "Interacting with the mitochondrial promoter DNA to modulate transcription by the mitochondrial RNA polymerase. [GOC:txnOH-2018, PMID:18391175]" }, { "answer": "RNA binding", "description": "Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah]" }, { "answer": "rRNA (adenine-N6,N6-)-dimethyltransferase activity", "description": "Catalysis of the dimethylation of two adjacent adenine residues in a rRNA, using S-adenosyl-L-methionine as a methyl donor. [ISBN:1555811337, PMID:10690410]" } ], "type": "multi-hop" }, { "question": "What is the molecular function of the protein translated from the gene GZMH?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Molecular_function", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "GZMH", "name": "granzyme H" }, "MidAttributes": { "id": "P20718", "name": "GZMH" }, "answer": [ { "answer": "serine-type endopeptidase activity", "description": "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]" } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene NFATC4 and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "NFATC4", "name": "nuclear factor of activated T cells 4" }, "MidAttributes": { "id": "Q14934", "name": "NFATC4" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene NR4A3 and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "NR4A3", "name": "nuclear receptor subfamily 4 group A member 3" }, "MidAttributes": { "id": "Q92570", "name": "NR4A3" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene RAB11FIP3 and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "RAB11FIP3", "name": "RAB11 family interacting protein 3" }, "MidAttributes": { "id": "O75154", "name": "RAB11FIP3" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene PI4KB and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "PI4KB", "name": "phosphatidylinositol 4-kinase beta" }, "MidAttributes": { "id": "Q9UBF8", "name": "PI4KB" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene POU2F1 and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "POU2F1", "name": "POU class 2 homeobox 1" }, "MidAttributes": { "id": "P14859", "name": "POU2F1" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene ROR2 and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "ROR2", "name": "receptor tyrosine kinase like orphan receptor 2" }, "MidAttributes": { "id": "Q01974", "name": "ROR2" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene SIVA1 and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "SIVA1", "name": "SIVA1 apoptosis inducing factor" }, "MidAttributes": { "id": "O15304", "name": "SIVA1" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene PDIK1L and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "PDIK1L", "name": "PDLIM1 interacting kinase 1 like" }, "MidAttributes": { "id": "Q8N165", "name": "PDIK1L" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene VAMP3 and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "VAMP3", "name": "vesicle associated membrane protein 3" }, "MidAttributes": { "id": "Q15836", "name": "VAMP3" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene ORAI1 and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "ORAI1", "name": "ORAI calcium release-activated calcium modulator 1" }, "MidAttributes": { "id": "Q96D31", "name": "ORAI1" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene NCOR2 and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "NCOR2", "name": "nuclear receptor corepressor 2" }, "MidAttributes": { "id": "Q9Y618", "name": "NCOR2" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene ACOT4 and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "ACOT4", "name": "acyl-CoA thioesterase 4" }, "MidAttributes": { "id": "Q8N9L9", "name": "ACOT4" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene PKN1 and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "PKN1", "name": "protein kinase N1" }, "MidAttributes": { "id": "Q16512", "name": "PKN1" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene CIC and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "CIC", "name": "capicua transcriptional repressor" }, "MidAttributes": { "id": "Q96RK0", "name": "CIC" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene CDH5 and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "CDH5", "name": "cadherin 5" }, "MidAttributes": { "id": "P33151", "name": "CDH5" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene AKAP13 and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "AKAP13", "name": "A-kinase anchoring protein 13" }, "MidAttributes": { "id": "Q12802", "name": "AKAP13" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene LPIN1 and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "LPIN1", "name": "lipin 1" }, "MidAttributes": { "id": "Q14693", "name": "LPIN1" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene MAP2K6 and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "MAP2K6", "name": "mitogen-activated protein kinase kinase 6" }, "MidAttributes": { "id": "P52564", "name": "MAP2K6" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene FOXP3 and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "FOXP3", "name": "forkhead box P3" }, "MidAttributes": { "id": "Q9BZS1", "name": "FOXP3" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene ARHGDIB and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "ARHGDIB", "name": "Rho GDP dissociation inhibitor beta" }, "MidAttributes": { "id": "P52566", "name": "ARHGDIB" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene CDCA8 and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "CDCA8", "name": "cell division cycle associated 8" }, "MidAttributes": { "id": "Q53HL2", "name": "CDCA8" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene MAP2K2 and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "MAP2K2", "name": "mitogen-activated protein kinase kinase 2" }, "MidAttributes": { "id": "P36507", "name": "MAP2K2" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene MEF2C and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "MEF2C", "name": "myocyte enhancer factor 2C" }, "MidAttributes": { "id": "Q06413", "name": "MEF2C" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene H2AC16 and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "H2AC16", "name": "H2A clustered histone 16" }, "MidAttributes": { "id": "P0C0S8", "name": "H2AC11" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene PFKFB3 and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "PFKFB3", "name": "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3" }, "MidAttributes": { "id": "Q16875", "name": "PFKFB3" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene CTPS1 and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "CTPS1", "name": "CTP synthase 1" }, "MidAttributes": { "id": "P17812", "name": "CTPS1" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene STK38 and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "STK38", "name": "serine/threonine kinase 38" }, "MidAttributes": { "id": "Q15208", "name": "STK38" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene GRK1 and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "GRK1", "name": "G protein-coupled receptor kinase 1" }, "MidAttributes": { "id": "Q15835", "name": "GRK1" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene GLRB and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "GLRB", "name": "glycine receptor beta" }, "MidAttributes": { "id": "P48167", "name": "GLRB" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene CHRNA7 and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "CHRNA7", "name": "cholinergic receptor nicotinic alpha 7 subunit" }, "MidAttributes": { "id": "P36544", "name": "CHRNA7" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene LYN and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "LYN", "name": "LYN proto-oncogene, Src family tyrosine kinase" }, "MidAttributes": { "id": "P07948", "name": "LYN" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene SHCBP1 and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "SHCBP1", "name": "SHC binding and spindle associated 1" }, "MidAttributes": { "id": "Q8NEM2", "name": "SHCBP1" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene STAT3 and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "STAT3", "name": "signal transducer and activator of transcription 3" }, "MidAttributes": { "id": "P40763", "name": "STAT3" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene IQGAP2 and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "IQGAP2", "name": "IQ motif containing GTPase activating protein 2" }, "MidAttributes": { "id": "Q13576", "name": "IQGAP2" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene NCOA1 and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "NCOA1", "name": "nuclear receptor coactivator 1" }, "MidAttributes": { "id": "Q15788", "name": "NCOA1" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene CTBP1 and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "CTBP1", "name": "C-terminal binding protein 1" }, "MidAttributes": { "id": "Q13363", "name": "CTBP1" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene HCN4 and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "HCN4", "name": "hyperpolarization activated cyclic nucleotide gated potassium channel 4" }, "MidAttributes": { "id": "Q9Y3Q4", "name": "HCN4" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene DLC1 and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "DLC1", "name": "DLC1 Rho GTPase activating protein" }, "MidAttributes": { "id": "Q96QB1", "name": "DLC1" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene PREB and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "PREB", "name": "prolactin regulatory element binding" }, "MidAttributes": { "id": "Q9HCU5", "name": "PREB" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene XRCC6 and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "XRCC6", "name": "X-ray repair cross complementing 6" }, "MidAttributes": { "id": "P12956", "name": "XRCC6" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene DAP3 and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "DAP3", "name": "death associated protein 3" }, "MidAttributes": { "id": "P51398", "name": "DAP3" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene ACTN4 and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "ACTN4", "name": "actinin alpha 4" }, "MidAttributes": { "id": "O43707", "name": "ACTN4" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene BCL6 and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "BCL6", "name": "BCL6 transcription repressor" }, "MidAttributes": { "id": "P41182", "name": "BCL6" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene PTPN11 and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "PTPN11", "name": "protein tyrosine phosphatase non-receptor type 11" }, "MidAttributes": { "id": "Q06124", "name": "PTPN11" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene PPP1CA and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "PPP1CA", "name": "protein phosphatase 1 catalytic subunit alpha" }, "MidAttributes": { "id": "P62136", "name": "PPP1CA" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What is the modified protein translated from the gene ERBB3 and its modification site?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Modified_protein", "EdgeTypes": [ "TRANSLATED_INTO", "HAS_MODIFIED_SITE" ], "InitialAttributes": { "id": "ERBB3", "name": "erb-b2 receptor tyrosine kinase 3" }, "MidAttributes": { "id": "P21860", "name": "ERBB3" }, "answer": [ { "answer": null, "description": null } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene SLC25A1?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "SLC25A1", "name": "solute carrier family 25 member 1" }, "MidAttributes": { "id": "P53007", "name": "SLC25A1" }, "answer": [ { "answer": "gluconeogenesis", "description": "The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. [MetaCyc:GLUCONEO-PWY]" }, { "answer": "fatty-acyl-CoA biosynthetic process", "description": "The chemical reactions and pathways resulting in the formation of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group. [ISBN:0198506732]" }, { "answer": "mitochondrial citrate transmembrane transport", "description": "The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into or out of a mitochondrial matrix. [GOC:ai, PMID:20371607]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene ZNF614?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "ZNF614", "name": "zinc finger protein 614" }, "MidAttributes": { "id": "Q8N883", "name": "ZNF614" }, "answer": [ { "answer": "biological_process", "description": "A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. [GOC:pdt]" }, { "answer": "regulation of transcription by RNA polymerase II", "description": "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene GOLT1A?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "GOLT1A", "name": "golgi transport 1A" }, "MidAttributes": { "id": "Q6ZVE7", "name": "GOLT1A" }, "answer": [ { "answer": "retrograde transport, endosome to Golgi", "description": "The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport. [GOC:jl, PMID:10873832, PMID:16936697]" }, { "answer": "endoplasmic reticulum to Golgi vesicle-mediated transport", "description": "The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]" }, { "answer": "protein transport", "description": "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]" }, { "answer": "biological_process", "description": "A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. [GOC:pdt]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene MBLAC2?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "MBLAC2", "name": "metallo-beta-lactamase domain containing 2" }, "MidAttributes": { "id": "Q68D91", "name": "MBLAC2" }, "answer": [ { "answer": "fatty acid metabolic process", "description": "The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. [ISBN:0198547684]" }, { "answer": "biological_process", "description": "A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. [GOC:pdt]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene MTO1?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "MTO1", "name": "mitochondrial tRNA translation optimization 1" }, "MidAttributes": { "id": "Q9Y2Z2", "name": "MTO1" }, "answer": [ { "answer": "mitochondrial tRNA wobble uridine modification", "description": "The process in which a uridine in position 34 of a mitochondrial tRNA is post-transcriptionally modified. [GOC:mah, GOC:mcc]" }, { "answer": "tRNA methylation", "description": "The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule. [GOC:mah]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene FBXL6?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "FBXL6", "name": "F-box and leucine rich repeat protein 6" }, "MidAttributes": { "id": "Q8N531", "name": "FBXL6" }, "answer": [ { "answer": "proteolysis", "description": "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah]" }, { "answer": "SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "description": "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome. [PMID:15380083]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene CPD?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "CPD", "name": "carboxypeptidase D" }, "MidAttributes": { "id": "O75976", "name": "CPD" }, "answer": [ { "answer": "peptide metabolic process", "description": "The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. [GOC:go_curators]" }, { "answer": "protein processing", "description": "Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein. [GOC:curators, GOC:jl, GOC:jsg]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene ASDURF?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "ASDURF", "name": "ASNSD1 upstream open reading frame" }, "MidAttributes": { "id": "L0R819", "name": "ASDURF" }, "answer": [ { "answer": "protein stabilization", "description": "Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. [GOC:ai]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene ZNF552?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "ZNF552", "name": "zinc finger protein 552" }, "MidAttributes": { "id": "Q9H707", "name": "ZNF552" }, "answer": [ { "answer": "regulation of transcription by RNA polymerase II", "description": "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene PSMD3?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "PSMD3", "name": "proteasome 26S subunit, non-ATPase 3" }, "MidAttributes": { "id": "O43242", "name": "PSMD3" }, "answer": [ { "answer": "ubiquitin-dependent protein catabolic process", "description": "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein. [GOC:go_curators]" }, { "answer": "proteasome-mediated ubiquitin-dependent protein catabolic process", "description": "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. [GOC:go_curators]" }, { "answer": "regulation of protein catabolic process", "description": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. [GOC:go_curators, GOC:jl]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene ORAI3?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "ORAI3", "name": "ORAI calcium release-activated calcium modulator 3" }, "MidAttributes": { "id": "Q9BRQ5", "name": "ORAI3" }, "answer": [ { "answer": "store-operated calcium entry", "description": "A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum. [GOC:hjd, PMID:11120592, PMID:17956991]" }, { "answer": "calcium ion transmembrane transport", "description": "A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene OR4F16?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "OR4F16", "name": "olfactory receptor family 4 subfamily F member 16" }, "MidAttributes": { "id": "Q6IEY1", "name": "OR4F3" }, "answer": [ { "answer": "G protein-coupled receptor signaling pathway", "description": "The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]" }, { "answer": "detection of chemical stimulus involved in sensory perception of smell", "description": "The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal. [GOC:ai]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene ZFTA?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "ZFTA", "name": "zinc finger translocation associated" }, "MidAttributes": { "id": "C9JLR9", "name": "ZFTA" }, "answer": [ { "answer": "negative regulation of DNA-templated transcription", "description": "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene OR3A3?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "OR3A3", "name": "olfactory receptor family 3 subfamily A member 3" }, "MidAttributes": { "id": "P47888", "name": "OR3A3" }, "answer": [ { "answer": "signal transduction", "description": "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]" }, { "answer": "detection of chemical stimulus involved in sensory perception of smell", "description": "The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal. [GOC:ai]" }, { "answer": "G protein-coupled receptor signaling pathway", "description": "The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene OR6X1?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "OR6X1", "name": "olfactory receptor family 6 subfamily X member 1" }, "MidAttributes": { "id": "Q8NH79", "name": "OR6X1" }, "answer": [ { "answer": "G protein-coupled receptor signaling pathway", "description": "The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]" }, { "answer": "detection of chemical stimulus involved in sensory perception of smell", "description": "The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal. [GOC:ai]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene VSTM2L?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "VSTM2L", "name": "V-set and transmembrane domain containing 2 like" }, "MidAttributes": { "id": "Q96N03", "name": "VSTM2L" }, "answer": [ { "answer": "negative regulation of neuron apoptotic process", "description": "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. [GOC:go_curators, GOC:mtg_apoptosis]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene RANBP17?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "RANBP17", "name": "RAN binding protein 17" }, "MidAttributes": { "id": "Q9H2T7", "name": "RANBP17" }, "answer": [ { "answer": "protein export from nucleus", "description": "The directed movement of a protein from the nucleus into the cytoplasm. [GOC:jl]" }, { "answer": "mRNA transport", "description": "The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]" }, { "answer": "protein import into nucleus", "description": "The directed movement of a protein from the cytoplasm to the nucleus. [GOC:jl]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene COL17A1?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "COL17A1", "name": "collagen type XVII alpha 1 chain" }, "MidAttributes": { "id": "Q9UMD9", "name": "COL17A1" }, "answer": [ { "answer": "extracellular matrix organization", "description": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix. [GOC:mah]" }, { "answer": "cell-matrix adhesion", "description": "The binding of a cell to the extracellular matrix via adhesion molecules. [GOC:hb]" }, { "answer": "hemidesmosome assembly", "description": "Assembly of hemidesmosomes, integrin-containing protein complexes that bind to laminin in the basal lamina. Hemidesmosomes form the contact between the basal surface of epithelial cells and the underlying basal lamina. [GOC:dgh, PMID:15983403]" }, { "answer": "epidermis development", "description": "The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. [GOC:go_curators, UBERON:0001003]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene SH3TC1?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "SH3TC1", "name": "SH3 domain and tetratricopeptide repeats 1" }, "MidAttributes": { "id": "Q8TE82", "name": "SH3TC1" }, "answer": [ { "answer": "biological_process", "description": "A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. [GOC:pdt]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene ZKSCAN4?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "ZKSCAN4", "name": "zinc finger with KRAB and SCAN domains 4" }, "MidAttributes": { "id": "Q969J2", "name": "ZKSCAN4" }, "answer": [ { "answer": "regulation of transcription by RNA polymerase II", "description": "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene RARS1?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "RARS1", "name": "arginyl-tRNA synthetase 1" }, "MidAttributes": { "id": "P54136", "name": "RARS1" }, "answer": [ { "answer": "arginyl-tRNA aminoacylation", "description": "The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. The arginyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of an alanine accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. [GOC:mcc, ISBN:0716730510]" }, { "answer": "tRNA aminoacylation for protein translation", "description": "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis. [GOC:ma]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene PCMTD1?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "PCMTD1", "name": "protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1" }, "MidAttributes": { "id": "Q96MG8", "name": "PCMTD1" }, "answer": [ { "answer": "protein ubiquitination", "description": "The process in which one or more ubiquitin groups are added to a protein. [GOC:ai]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene TRBV3-1?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "TRBV3-1", "name": "T cell receptor beta variable 3-1" }, "MidAttributes": { "id": "A0A576", "name": "TRBV3-1" }, "answer": [ { "answer": "adaptive immune response", "description": "An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory). [GO_REF:0000022, GOC:add, ISBN:0781735149]" }, { "answer": "cell surface receptor signaling pathway", "description": "The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription. [GOC:signaling]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene UST?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "UST", "name": "uronyl 2-sulfotransferase" }, "MidAttributes": { "id": "Q9Y2C2", "name": "UST" }, "answer": [ { "answer": "establishment of cell polarity", "description": "The specification and formation of anisotropic intracellular organization or cell growth patterns. [GOC:mah]" }, { "answer": "protein sulfation", "description": "The addition of a sulfate group as an ester to a protein amino acid. [GOC:curators]" }, { "answer": "dermatan sulfate biosynthetic process", "description": "The chemical reactions and pathways resulting in the formation of dermatan sulfate, any glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. [GOC:mah, ISBN:0198506732]" }, { "answer": "regulation of axonogenesis", "description": "Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron. [GOC:ai]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene GALNT15?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "GALNT15", "name": "polypeptide N-acetylgalactosaminyltransferase 15" }, "MidAttributes": { "id": "Q8N3T1", "name": "GALNT15" }, "answer": [ { "answer": "protein O-linked glycosylation", "description": "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan. [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212]" }, { "answer": "O-glycan processing", "description": "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form a core O-glycan structure. [GOC:mah, GOC:pr, PMID:10580130]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene AIFM3?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "AIFM3", "name": "apoptosis inducing factor mitochondria associated 3" }, "MidAttributes": { "id": "Q96NN9", "name": "AIFM3" }, "answer": [ { "answer": "execution phase of apoptosis", "description": "A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. [GOC:mtg_apoptosis, PMID:21760595]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene BNIP2?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "BNIP2", "name": "BCL2 interacting protein 2" }, "MidAttributes": { "id": "Q12982", "name": "BNIP2" }, "answer": [ { "answer": "negative regulation of apoptotic process", "description": "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]" }, { "answer": "apoptotic process", "description": "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]" }, { "answer": "response to oxygen-glucose deprivation", "description": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the deprivation of oxygen and glucose. [GOC:sl, PMID:21525936]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene MYCT1?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "MYCT1", "name": "MYC target 1" }, "MidAttributes": { "id": "Q8N699", "name": "MYCT1" }, "answer": [ { "answer": "hematopoietic stem cell homeostasis", "description": "Any biological process involved in the maintenance of the steady-state number of hematopoietic stem cells within a population of cells. [GOC:dph, PMID:21508411]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene ZNF33A?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "ZNF33A", "name": "zinc finger protein 33A" }, "MidAttributes": { "id": "Q06730", "name": "ZNF33A" }, "answer": [ { "answer": "regulation of transcription by RNA polymerase II", "description": "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]" }, { "answer": "positive regulation of transcription by RNA polymerase II", "description": "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]" }, { "answer": "regulation of DNA-templated transcription", "description": "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene TOMM22?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "TOMM22", "name": "translocase of outer mitochondrial membrane 22" }, "MidAttributes": { "id": "Q9NS69", "name": "TOMM22" }, "answer": [ { "answer": "protein targeting to mitochondrion", "description": "The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein. [GOC:mcc, ISBN:0716731363]" }, { "answer": "protein insertion into mitochondrial outer membrane", "description": "The process comprising the insertion of proteins from outside the organelle into the mitochondrial outer membrane, mediated by large outer membrane translocase complexes. [GOC:mcc, GOC:vw, PMID:18672008]" }, { "answer": "protein transmembrane transport", "description": "The process in which a protein is transported across a membrane. [GOC:mah, GOC:vw]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene GJA9?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "GJA9", "name": "gap junction protein alpha 9" }, "MidAttributes": { "id": "P57773", "name": "GJA9" }, "answer": [ { "answer": "transmembrane transport", "description": "The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:dph, GOC:jid]" }, { "answer": "cell-cell signaling", "description": "Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. [GOC:dos, GOC:mah]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene NNAT?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "NNAT", "name": "neuronatin" }, "MidAttributes": { "id": "Q16517", "name": "NNAT" }, "answer": [ { "answer": "brain development", "description": "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]" }, { "answer": "positive regulation of insulin secretion", "description": "Any process that activates or increases the frequency, rate or extent of the regulated release of insulin. [GOC:mah]" }, { "answer": "protein lipoylation", "description": "The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine. [RESID:AA0118]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene DMRTC1B?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "DMRTC1B", "name": "DMRT like family C1B" }, "MidAttributes": { "id": "Q5HYR2", "name": "DMRTC1" }, "answer": [ { "answer": "regulation of DNA-templated transcription", "description": "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene SMG7?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "SMG7", "name": "SMG7 nonsense mediated mRNA decay factor" }, "MidAttributes": { "id": "Q92540", "name": "SMG7" }, "answer": [ { "answer": "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "description": "The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. [GOC:krc, GOC:ma, PMID:10025395]" }, { "answer": "mRNA export from nucleus", "description": "The directed movement of mRNA from the nucleus to the cytoplasm. [GOC:ma]" }, { "answer": "regulation of dephosphorylation", "description": "Any process that modulates the frequency, rate or extent of removal of phosphate groups from a molecule. [GOC:bf]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene NOTCH2NLA?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "NOTCH2NLA", "name": "notch 2 N-terminal like A" }, "MidAttributes": { "id": "Q7Z3S9", "name": "NOTCH2NLA" }, "answer": [ { "answer": "positive regulation of Notch signaling pathway", "description": "Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway. [GOC:go_curators]" }, { "answer": "cerebral cortex development", "description": "The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]" }, { "answer": "Notch signaling pathway", "description": "The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:go_curators, GOC:signaling]" }, { "answer": "cell differentiation", "description": "The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. [ISBN:0198506732]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene TFB2M?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "TFB2M", "name": "transcription factor B2, mitochondrial" }, "MidAttributes": { "id": "Q9H5Q4", "name": "TFB2M" }, "answer": [ { "answer": "rRNA methylation", "description": "The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule. [GOC:mah]" }, { "answer": "transcription initiation at mitochondrial promoter", "description": "A transcription initiation process that takes place at a promoter on the mitochondrial chromosome. [PMID:33127643]" }, { "answer": "mitochondrial transcription", "description": "The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase. [GOC:jl, PMID:23632312]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene GZMH?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "GZMH", "name": "granzyme H" }, "MidAttributes": { "id": "P20718", "name": "GZMH" }, "answer": [ { "answer": "killing of cells of another organism", "description": "Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions. [GOC:add]" }, { "answer": "proteolysis", "description": "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah]" }, { "answer": "apoptotic process", "description": "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene ZNF569?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "ZNF569", "name": "zinc finger protein 569" }, "MidAttributes": { "id": "Q5MCW4", "name": "ZNF569" }, "answer": [ { "answer": "regulation of transcription by RNA polymerase II", "description": "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene PPA2?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "PPA2", "name": "inorganic pyrophosphatase 2" }, "MidAttributes": { "id": "Q9H2U2", "name": "PPA2" }, "answer": [ { "answer": "phosphate-containing compound metabolic process", "description": "The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. [GOC:ai]" }, { "answer": "diphosphate metabolic process", "description": "The chemical reactions and pathways involving diphosphate, the anion or salt of diphosphoric acid. [GOC:pde]" }, { "answer": "regulation of mitochondrial membrane potential", "description": "Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. [GOC:ai]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene PDZD2?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "PDZD2", "name": "PDZ domain containing 2" }, "MidAttributes": { "id": "O15018", "name": "PDZD2" }, "answer": [ { "answer": "cell adhesion", "description": "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. [GOC:hb, GOC:pf]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene ACOXL?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "ACOXL", "name": "acyl-CoA oxidase like" }, "MidAttributes": { "id": "Q9NUZ1", "name": "ACOXL" }, "answer": [ { "answer": "fatty acid beta-oxidation using acyl-CoA oxidase", "description": "A fatty acid beta-oxidation pathway in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). [GOC:mah, MetaCyc:PWY-5136]" }, { "answer": "biological_process", "description": "A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. [GOC:pdt]" }, { "answer": "lipid homeostasis", "description": "Any process involved in the maintenance of an internal steady state of lipid within an organism or cell. [GOC:BHF, GOC:rl]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene CNNM3?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "CNNM3", "name": "cyclin and CBS domain divalent metal cation transport mediator 3" }, "MidAttributes": { "id": "Q8NE01", "name": "CNNM3" }, "answer": [ { "answer": "monoatomic ion transport", "description": "The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:ai]" }, { "answer": "magnesium ion homeostasis", "description": "Any process involved in the maintenance of an internal steady state of magnesium ions within an organism or cell. [GOC:dph, GOC:tb]" }, { "answer": "transmembrane transport", "description": "The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:dph, GOC:jid]" }, { "answer": "transport", "description": "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein. [GOC:dos, GOC:dph, GOC:jl, GOC:mah]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene TMEM68?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "TMEM68", "name": "transmembrane protein 68" }, "MidAttributes": { "id": "Q96MH6", "name": "TMEM68" }, "answer": [ { "answer": "triglyceride biosynthetic process", "description": "The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol. [ISBN:0198506732]" }, { "answer": "lipid metabolic process", "description": "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. [GOC:ma]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene FBXL12?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "FBXL12", "name": "F-box and leucine rich repeat protein 12" }, "MidAttributes": { "id": "Q9NXK8", "name": "FBXL12" }, "answer": [ { "answer": "protein ubiquitination", "description": "The process in which one or more ubiquitin groups are added to a protein. [GOC:ai]" }, { "answer": "SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "description": "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome. [PMID:15380083]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene ABLIM2?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "ABLIM2", "name": "actin binding LIM protein family member 2" }, "MidAttributes": { "id": "Q6H8Q1", "name": "ABLIM2" }, "answer": [ { "answer": "lamellipodium assembly", "description": "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. [GOC:mah, ISBN:0815316194]" }, { "answer": "cytoskeleton organization", "description": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. [GOC:dph, GOC:jl, GOC:mah]" } ], "type": "multi-hop" }, { "question": "What biological processes are associated with the protein encoded by the gene PSG8?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Biological_process", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "PSG8", "name": "pregnancy specific beta-1-glycoprotein 8" }, "MidAttributes": { "id": "Q9UQ74", "name": "PSG8" }, "answer": [ { "answer": "regulation of immune system process", "description": "Any process that modulates the frequency, rate, or extent of an immune system process. [GOC:add]" }, { "answer": "signal transduction", "description": "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene PDZD4?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "PDZD4", "name": "PDZ domain containing 4" }, "MidAttributes": { "id": "Q76G19", "name": "PDZD4" }, "answer": [ { "answer": "synovial sarcoma", "description": "A synovium cancer which develops in the synovial membrane of the joints. [url:http\\://en.wikipedia.org/wiki/Synovial_sarcoma, url:http\\://www.cancer.gov/dictionary?cdrid=44626]" }, { "answer": "nephrogenic diabetes insipidus", "description": "A diabetes insipidus that is characterized by a complete or partial resistance of the kidneys to vasopressin (ADH). [url:http\\://en.wikipedia.org/wiki/Nephrogenic_diabetes_insipidus, url:http\\://ghr.nlm.nih.gov/condition/nephrogenic-diabetes-insipidus, url:https\\://medlineplus.gov/ency/article/000511.htm]" }, { "answer": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland. [url:http\\://en.wikipedia.org/wiki/Breast_cancer, url:http\\://en.wikipedia.org/wiki/Mammary, url:http\\://www.cancer.gov/cancertopics/types/breast, url:http\\://www.nlm.nih.gov/medlineplus/breastcancer.html, url:https\\://www.genome.gov/Genetic-Disorders/Breast-Cancer]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene CCDC7?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "CCDC7", "name": "coiled-coil domain containing 7" }, "MidAttributes": { "id": "Q96M83", "name": "CCDC7" }, "answer": [ { "answer": "endometrial cancer", "description": "A uterine cancer that is located_in tissues lining the uterus. [url:http\\://www.cancer.gov/dictionary?CdrID=444987]" }, { "answer": "endometrial carcinoma", "description": "A endometrial cancer that is located_in the tissue lining the uterus. [url:http\\://www.cancer.gov/cancertopics/types/endometrial]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene OR13G1?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "OR13G1", "name": "olfactory receptor family 13 subfamily G member 1" }, "MidAttributes": { "id": "Q8NGZ3", "name": "OR13G1" }, "answer": [ { "answer": "atherosclerosis", "description": "atherosclerosis" }, { "answer": "arteriosclerotic cardiovascular disease", "description": "arteriosclerotic cardiovascular disease" }, { "answer": "coronary artery disease", "description": "An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles. [url:http\\://en.wikipedia.org/wiki/Coronary_heart_disease]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene TRIM54?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "TRIM54", "name": "tripartite motif containing 54" }, "MidAttributes": { "id": "Q9BYV2", "name": "TRIM54" }, "answer": [ { "answer": "autosomal dominant hyaline body myopathy", "description": "A hyaline body myopathy that has_material_basis_in heterozygous mutation in MYH7 on 14q11.2. [url:https\\://www.ncbi.nlm.nih.gov/pubmed/16684601]" }, { "answer": "lung non-small cell carcinoma", "description": "A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma. [url:http\\://en.wikipedia.org/wiki/Non-small-cell_lung_carcinoma]" }, { "answer": "lung cancer", "description": "A respiratory system cancer that is located_in the lung. [url:http\\://en.wikipedia.org/wiki/Lung_cancer]" }, { "answer": "myopathy", "description": "A muscular disease in which the muscle fibers do not function resulting in muscular weakness. [url:http\\://en.wikipedia.org/wiki/Myopathy]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene OR7C2?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "OR7C2", "name": "olfactory receptor family 7 subfamily C member 2" }, "MidAttributes": { "id": "O60412", "name": "OR7C2" }, "answer": [ { "answer": "peripheral nervous system neoplasm", "description": "A nervous system cancer that is located in the peripheral nervous system. [url:http\\://en.wikipedia.org/wiki/Peripheral_nervous_system]" }, { "answer": "autonomic nervous system neoplasm", "description": "A peripheral nervous system neoplasm that is located_in the autonomic nervous system. [url:http\\://en.wikipedia.org/wiki/Autonomic_nervous_system]" }, { "answer": "neuroblastoma", "description": "An autonomic nervous system neoplasm that derives_from immature nerve cells. [url:http\\://www.cancer.gov/cancertopics/types/neuroblastoma]" }, { "answer": "anxiety disorder", "description": "A cognitive disorder that involves an excessive, irrational dread of everyday situations. [url:http\\://www.nimh.nih.gov/health/topics/anxiety-disorders/index.shtml]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene CTAGE8?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "CTAGE8", "name": "CTAGE family member 8" }, "MidAttributes": { "id": "P0CG41", "name": "CTAGE8" }, "answer": [ { "answer": "lung squamous cell carcinoma", "description": "A non-small cell lung carcinoma that has_material_basis_in the squamous cell. [url:http\\://cancergenome.nih.gov/cancersselected/lungsquamouscell, url:http\\://en.wikipedia.org/wiki/Squamous-cell_carcinoma, url:http\\://en.wikipedia.org/wiki/Squamous_cell_carcinoma_of_the_lung, url:http\\://www.cancer.gov/dictionary?CdrID=46595]" }, { "answer": "large cell carcinoma", "description": "A carcinoma that is composed of large, monotonous rounded or overtly polygonal-shaped cells with abundant cytoplasm. [url:http\\://en.wikipedia.org/wiki/Carcinoma]" }, { "answer": "small cell carcinoma", "description": "A carcinoma that is an undifferentiated neoplasm composed of primitive-appearing cells. [url:http\\://en.wikipedia.org/wiki/Small_cell_carcinoma]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene DOCK10?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "DOCK10", "name": "dedicator of cytokinesis 10" }, "MidAttributes": { "id": "Q96BY6", "name": "DOCK10" }, "answer": [ { "answer": "chronic lymphocytic leukemia", "description": "A lymphocytic leukemia characterized by over production of B-cells and their accumulation in bone marrow and blood. [url:http\\://en.wikipedia.org/wiki/B-cell_chronic_lymphocytic_leukemia, url:http\\://www.cancer.gov/dictionary?cdrid=346545]" }, { "answer": "Richter's syndrome", "description": "Richter's syndrome" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene STMN4?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "STMN4", "name": "stathmin 4" }, "MidAttributes": { "id": "Q9H169", "name": "STMN4" }, "answer": [ { "answer": "cancer", "description": "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis. [url:http\\://en.wikipedia.org/wiki/cancer, url:http\\://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=cancer]" }, { "answer": "neuroblastoma", "description": "An autonomic nervous system neoplasm that derives_from immature nerve cells. [url:http\\://www.cancer.gov/cancertopics/types/neuroblastoma]" }, { "answer": "autistic disorder", "description": "An autism spectrum disorder that is characterized by symptoms across all three symptom domains (communication, social, restricted repetitive interests and behaviors), delayed language development, and symptom onset prior to age 3 years. [url:http\\://en.wikipedia.org/wiki/Autism, url:http\\://www.neurodevnet.ca]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene TBC1D3B?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "TBC1D3B", "name": "TBC1 domain family member 3B" }, "MidAttributes": { "id": "A6NDS4", "name": "TBC1D3B" }, "answer": [ { "answer": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate. [url:http\\://www.cancer.gov/dictionary?CdrID=445079, url:https\\://www.genome.gov/Genetic-Disorders/Prostate-Cancer]" }, { "answer": "prostate carcinoma", "description": "A prostate cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. [url:http\\://en.wikipedia.org/wiki/Carcinoma]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene PPP3R2?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "PPP3R2", "name": "protein phosphatase 3 regulatory subunit B, beta" }, "MidAttributes": { "id": "Q96LZ3", "name": "PPP3R2" }, "answer": [ { "answer": "arthritis", "description": "A bone inflammation disease that involves a response to irritation or injury, characterized by joint pain, swelling, stiffness located_in joint. [url:http\\://en.wikipedia.org/wiki/Arthritis, url:http\\://www.arthritis.org/, url:http\\://www.nlm.nih.gov/medlineplus/ency/article/001243.htm, url:https\\://www.cdc.gov/arthritis/index.htm]" }, { "answer": "arthropathy", "description": "A bone disease that is located_in the joint. [url:http\\://en.wikipedia.org/wiki/Arthropathy]" }, { "answer": "osteoarthritis", "description": "An arthritis that has_material_basis_in worn out cartilage located_in joint. [url:http\\://en.wikipedia.org/wiki/Osteoarthritis, url:http\\://www.mayoclinic.com/health/osteoarthritis/DS00019, url:http\\://www.nlm.nih.gov/medlineplus/ency/article/000423.htm]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene POU2AF2?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "POU2AF2", "name": "POU class 2 homeobox associating factor 2" }, "MidAttributes": { "id": "Q8IXP5", "name": "POU2AF2" }, "answer": [ { "answer": "large intestine cancer", "description": "An intestinal cancer that effects the long, tube-like organ that is connected to the small intestine at one end and the anus at the other. [url:http\\://en.wikipedia.org/wiki/Large_intestine]" }, { "answer": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum. [url:http\\://www.cancer.gov/dictionary?CdrID=444983]" }, { "answer": "colorectal carcinoma", "description": "A colorectal cancer that arises from the colon or rectum and invades through the muscularis mucosa into the submucosa. [url:https\\://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&version=16.12d&ns=NCI_Thesaurus&code=C4978]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene PCOTH?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "PCOTH", "name": "prostate and testis expressed opposite C1QTNF9B and MIPEP" }, "MidAttributes": { "id": "Q58A44", "name": "PCOTH" }, "answer": [ { "answer": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate. [url:http\\://www.cancer.gov/dictionary?CdrID=445079, url:https\\://www.genome.gov/Genetic-Disorders/Prostate-Cancer]" }, { "answer": "prostate carcinoma", "description": "A prostate cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. [url:http\\://en.wikipedia.org/wiki/Carcinoma]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene CYP26C1?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "CYP26C1", "name": "cytochrome P450 family 26 subfamily C member 1" }, "MidAttributes": { "id": "Q6V0L0", "name": "CYP26C1" }, "answer": [ { "answer": "schizophrenia", "description": "A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness. [url:http\\://en.wikipedia.org/wiki/Schizophrenia]" }, { "answer": "ankylosing spondylitis", "description": "A bone inflammation disease that results_in inflammation in the joints of the spine and pelvis. The disease has_symptom pain, has_symptom stiffness in the spine, has_symptom stiffness in the neck, has_symptom stiffness in the hips, has_symptom stiffness in the jaw and has_symptom stiffness in the rib cage. [url:http\\://en.wikipedia.org/wiki/Ankylosing_spondylitis, url:http\\://www.mayoclinic.com/health/ankylosing-spondylitis/DS00483, url:http\\://www.nlm.nih.gov/medlineplus/ency/article/000420.htm, url:http\\://www.spondylitis.org/about/as.aspx]" }, { "answer": "Laron syndrome", "description": "A syndrome characterized by marked short stature with normal or high serum growth hormone and low serum insulin-like growth factor-1 levels that has_material_basis_in homozygous or compound heterozygous mutation in GHR on chromosome 5p13-p12. [url:https\\://ghr.nlm.nih.gov/condition/laron-syndrome, url:https\\://www.ncbi.nlm.nih.gov/pubmed/8488849]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene TASOR?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "TASOR", "name": "transcription activation suppressor" }, "MidAttributes": { "id": "Q9UK61", "name": "TASOR" }, "answer": [ { "answer": "hypertension", "description": "An artery disease characterized by chronic elevated blood pressure in the arteries. [url:https\\://en.wikipedia.org/wiki/Hypertension, url:https\\://www.ncbi.nlm.nih.gov/pubmed/24352797]" }, { "answer": "essential hypertension", "description": "A hypertension with no known cause. It is the most common type of hypertension. [url:http\\://en.wikipedia.org/wiki/Essential_hypertension, url:http\\://www.merckmanuals.com/professional/cardiovascular_disorders/hypertension/overview_of_hypertension.html]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene NOSTRIN?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "NOSTRIN", "name": "nitric oxide synthase trafficking" }, "MidAttributes": { "id": "Q8IVI9", "name": "NOSTRIN" }, "answer": [ { "answer": "liver cirrhosis", "description": "liver cirrhosis" }, { "answer": "pancreatic carcinoma", "description": "A pancreas cancer that derives_from epithelial cells located_in the exocrine pancreas. [url:http\\://en.wikipedia.org/wiki/Carcinoma, url:http\\://www.cancer.gov/cancertopics/types/pancreatic]" }, { "answer": "alcoholic hepatitis", "description": "alcoholic hepatitis" }, { "answer": "pancreatic cancer", "description": "An endocrine gland cancer located_in the pancreas. [url:http\\://en.wikipedia.org/wiki/Pancreatic]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene TMPRSS9?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "TMPRSS9", "name": "transmembrane serine protease 9" }, "MidAttributes": { "id": "Q7Z410", "name": "TMPRSS9" }, "answer": [ { "answer": "pancreatic carcinoma", "description": "A pancreas cancer that derives_from epithelial cells located_in the exocrine pancreas. [url:http\\://en.wikipedia.org/wiki/Carcinoma, url:http\\://www.cancer.gov/cancertopics/types/pancreatic]" }, { "answer": "pancreatic cancer", "description": "An endocrine gland cancer located_in the pancreas. [url:http\\://en.wikipedia.org/wiki/Pancreatic]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene ZNF683?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "ZNF683", "name": "zinc finger protein 683" }, "MidAttributes": { "id": "Q8IZ20", "name": "ZNF683" }, "answer": [ { "answer": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate. [url:http\\://www.cancer.gov/dictionary?CdrID=445079, url:https\\://www.genome.gov/Genetic-Disorders/Prostate-Cancer]" }, { "answer": "prostate carcinoma", "description": "A prostate cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. [url:http\\://en.wikipedia.org/wiki/Carcinoma]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene GAGE2B?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "GAGE2B", "name": "G antigen 2B" }, "MidAttributes": { "id": "Q13066", "name": "GAGE2B" }, "answer": [ { "answer": "lung carcinoma", "description": "A lung cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells and is located_in the lungs and has_symptom cough and has_symptom chest discomfort or pain and has_symptom weight loss and has_symptom hemoptysis. [url:https\\://merck.com/mmpe/sec05/ch062/ch062b.html]" }, { "answer": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder. [url:http\\://en.wikipedia.org/wiki/Bladder_cancer]" }, { "answer": "melanoma", "description": "A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from melanocytes which are found in skin, the bowel and the eye. [url:http\\://en.wikipedia.org/wiki/Melanoma, url:https\\://www.ncbi.nlm.nih.gov/pubmed/22123420]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene DCDC1?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "DCDC1", "name": "doublecortin domain containing 1" }, "MidAttributes": { "id": "M0R2J8", "name": "DCDC1" }, "answer": [ { "answer": "esophagus squamous cell carcinoma", "description": "An esophageal carcinoma that derives_from epithelial squamous cells located_in the esophagus. [url:http\\://www.cancer.gov/cancertopics/types/esophageal]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene LRRTM4?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "LRRTM4", "name": "leucine rich repeat transmembrane neuronal 4" }, "MidAttributes": { "id": "Q86VH4", "name": "LRRTM4" }, "answer": [ { "answer": "retinitis pigmentosa 30", "description": "A retinitis pigmentosa that has_material_basis_in mutation in the FSCN2 gene on chromosome 17q25. [url:https\\://www.ncbi.nlm.nih.gov/pubmed/14609921]" }, { "answer": "age related macular degeneration", "description": "A degeneration of macula and posterior pole that is characterized by a loss of vision in the center of the visual field (the macula) resulting from damage to the retina and resulting in blurring of the sharp central vision. [url:http\\://en.wikipedia.org/wiki/Macular_degeneration]" }, { "answer": "macular degeneration", "description": "A retinal degeneration characterized by gradual deterioration of light-sensing cells in the tissues at the back of the eye and has_symptom vision loss. [url:http\\://ghr.nlm.nih.gov/condition/age-related-macular-degeneration, url:http\\://rarediseases.info.nih.gov/gard/10260/macular-degeneration/resources/1]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene DNAAF10?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "DNAAF10", "name": "dynein axonemal assembly factor 10" }, "MidAttributes": { "id": "Q96MX6", "name": "DNAAF10" }, "answer": [ { "answer": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland. [url:http\\://en.wikipedia.org/wiki/Breast_cancer, url:http\\://en.wikipedia.org/wiki/Mammary, url:http\\://www.cancer.gov/cancertopics/types/breast, url:http\\://www.nlm.nih.gov/medlineplus/breastcancer.html, url:https\\://www.genome.gov/Genetic-Disorders/Breast-Cancer]" }, { "answer": "breast carcinoma", "description": "A breast cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. [url:http\\://en.wikipedia.org/wiki/Breast_cancer]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene ACBD6?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "ACBD6", "name": "acyl-CoA binding domain containing 6" }, "MidAttributes": { "id": "Q9BR61", "name": "ACBD6" }, "answer": [ { "answer": "learning disability", "description": "A specific developmental disorder that involves difficulty in scholastic skills such as reading, writing, spelling, reasoning, recalling and/or organizing information resulting from the brain's inability to receive and process information. [url:http\\://en.wikipedia.org/wiki/Learning_disability, url:http\\://www.ldonline.org/ldbasics/whatisld]" }, { "answer": "intellectual disability", "description": "A specific developmental disorder that involves significant limitations both in mental functioning and in adaptive behavior such as communicating, taking care of him or herself, and social skills. [url:http\\://aaidd.org/intellectual-disability/definition#.WsPDT2VvqaU, url:https\\://en.wikipedia.org/wiki/Intellectual_disability]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene DHRS1?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "DHRS1", "name": "dehydrogenase/reductase 1" }, "MidAttributes": { "id": "Q96LJ7", "name": "DHRS1" }, "answer": [ { "answer": "cancer", "description": "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis. [url:http\\://en.wikipedia.org/wiki/cancer, url:http\\://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=cancer]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene URM1?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "URM1", "name": "ubiquitin related modifier 1" }, "MidAttributes": { "id": "Q9BTM9", "name": "URM1" }, "answer": [ { "answer": "T-cell acute lymphoblastic leukemia", "description": "An acute lymphoblastic leukemia that is characterized by too many T-cell lymphoblasts found in the bone marrow and blood. [url:https\\://www.cancer.gov/publications/dictionaries/cancer-terms/expand/T]" }, { "answer": "adult T-cell leukemia/lymphoma", "description": "A T-cell acute leukemia that results_in abnormal increase of lymphocytes, derives_from T-cells, has_material_basis_in Human T-lymphotropic virus 1 (HTLV-1), which is transmitted_by sexual contact, transmitted_by contaminated needles used by intravenous-drug users, and transmitted_by breast feeding. The infection results_in_formation_of skin lesions. [url:http\\://en.wikipedia.org/wiki/Adult_T-cell_leukemia/lymphoma, url:http\\://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&version=14.10d&code=C3184]" }, { "answer": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach. [url:http\\://cancergenome.nih.gov/cancersselected/stomach-esophagealcancer, url:http\\://en.wikipedia.org/wiki/Stomach]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene CDC16?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "CDC16", "name": "cell division cycle 16" }, "MidAttributes": { "id": "Q13042", "name": "CDC16" }, "answer": [ { "answer": "lung carcinoma", "description": "A lung cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells and is located_in the lungs and has_symptom cough and has_symptom chest discomfort or pain and has_symptom weight loss and has_symptom hemoptysis. [url:https\\://merck.com/mmpe/sec05/ch062/ch062b.html]" }, { "answer": "lung cancer", "description": "A respiratory system cancer that is located_in the lung. [url:http\\://en.wikipedia.org/wiki/Lung_cancer]" }, { "answer": "hepatocellular carcinoma", "description": "A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver. [url:http\\://cancergenome.nih.gov/cancersselected/LiverHepatocellularCarcinoma, url:http\\://en.wikipedia.org/wiki/Hepatocellular_carcinoma, url:http\\://www.omim.org/entry/114550]" }, { "answer": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver. [url:http\\://en.wikipedia.org/wiki/Liver]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene SYNGR2?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "SYNGR2", "name": "synaptogyrin 2" }, "MidAttributes": { "id": "O43760", "name": "SYNGR2" }, "answer": [ { "answer": "cancer", "description": "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis. [url:http\\://en.wikipedia.org/wiki/cancer, url:http\\://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=cancer]" }, { "answer": "viral infectious disease", "description": "A disease by infectious agent that results in infection, has_material_basis_in Viruses. [url:http\\://www.merck.com/mmhe/sec17/ch198/ch198a.html]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene DNAJB3?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "DNAJB3", "name": "DnaJ heat shock protein family (Hsp40) member B3" }, "MidAttributes": { "id": "Q8WWF6", "name": "DNAJB3" }, "answer": [ { "answer": "obesity", "description": "An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness. [url:https\\://en.wikipedia.org/wiki/Obesity]" }, { "answer": "type 2 diabetes mellitus", "description": "A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. [url:http\\://en.wikipedia.org/wiki/Diabetes, url:http\\://en.wikipedia.org/wiki/Diabetes_mellitus_type_2]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene ZNF540?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "ZNF540", "name": "zinc finger protein 540" }, "MidAttributes": { "id": "Q8NDQ6", "name": "ZNF540" }, "answer": [ { "answer": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum. [url:http\\://www.cancer.gov/dictionary?CdrID=444983]" }, { "answer": "colorectal carcinoma", "description": "A colorectal cancer that arises from the colon or rectum and invades through the muscularis mucosa into the submucosa. [url:https\\://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&version=16.12d&ns=NCI_Thesaurus&code=C4978]" }, { "answer": "large intestine cancer", "description": "An intestinal cancer that effects the long, tube-like organ that is connected to the small intestine at one end and the anus at the other. [url:http\\://en.wikipedia.org/wiki/Large_intestine]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene ZNF334?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "ZNF334", "name": "zinc finger protein 334" }, "MidAttributes": { "id": "Q9HCZ1", "name": "ZNF334" }, "answer": [ { "answer": "rheumatoid arthritis", "description": "An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint. [url:http\\://en.wikipedia.org/wiki/Rheumatoid_arthritis, url:http\\://www.mayoclinic.org/diseases-conditions/rheumatoid-arthritis/home/ovc-20197388, url:http\\://www.nlm.nih.gov/medlineplus/ency/article/000431.htm, url:http\\://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=rheumatoid%20arthritis]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene CD164L2?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "CD164L2", "name": "CD164 molecule like 2" }, "MidAttributes": { "id": "Q6UWJ8", "name": "CD164L2" }, "answer": [ { "answer": "essential hypertension", "description": "A hypertension with no known cause. It is the most common type of hypertension. [url:http\\://en.wikipedia.org/wiki/Essential_hypertension, url:http\\://www.merckmanuals.com/professional/cardiovascular_disorders/hypertension/overview_of_hypertension.html]" }, { "answer": "hypertension", "description": "An artery disease characterized by chronic elevated blood pressure in the arteries. [url:https\\://en.wikipedia.org/wiki/Hypertension, url:https\\://www.ncbi.nlm.nih.gov/pubmed/24352797]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene CATSPERZ?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "CATSPERZ", "name": "catsper channel auxiliary subunit zeta" }, "MidAttributes": { "id": "Q9NTU4", "name": "CATSPERZ" }, "answer": [ { "answer": "cancer", "description": "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis. [url:http\\://en.wikipedia.org/wiki/cancer, url:http\\://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=cancer]" }, { "answer": "ovarian cancer", "description": "A female reproductive organ cancer that is located_in the ovary. [url:http\\://www.cancer.gov/dictionary?CdrID=445074]" }, { "answer": "ovarian carcinoma", "description": "An ovarian cancer that has_material_basis_in epithelial tissue and is located_in the ovary. [url:https\\://www.cancer.gov/types/ovarian]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene GALNT9?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "GALNT9", "name": "polypeptide N-acetylgalactosaminyltransferase 9" }, "MidAttributes": { "id": "Q9HCQ5", "name": "GALNT9" }, "answer": [ { "answer": "breast carcinoma", "description": "A breast cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. [url:http\\://en.wikipedia.org/wiki/Breast_cancer]" }, { "answer": "neuroblastoma", "description": "An autonomic nervous system neoplasm that derives_from immature nerve cells. [url:http\\://www.cancer.gov/cancertopics/types/neuroblastoma]" }, { "answer": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland. [url:http\\://en.wikipedia.org/wiki/Breast_cancer, url:http\\://en.wikipedia.org/wiki/Mammary, url:http\\://www.cancer.gov/cancertopics/types/breast, url:http\\://www.nlm.nih.gov/medlineplus/breastcancer.html, url:https\\://www.genome.gov/Genetic-Disorders/Breast-Cancer]" }, { "answer": "cancer", "description": "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis. [url:http\\://en.wikipedia.org/wiki/cancer, url:http\\://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=cancer]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene DUSP15?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "DUSP15", "name": "dual specificity phosphatase 15" }, "MidAttributes": { "id": "Q9H1R2", "name": "DUSP15" }, "answer": [ { "answer": "multiple sclerosis", "description": "A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring. [url:http\\://en.wikipedia.org/wiki/Multiple_sclerosis, url:https\\://ghr.nlm.nih.gov/condition/multiple-sclerosis]" }, { "answer": "autistic disorder", "description": "An autism spectrum disorder that is characterized by symptoms across all three symptom domains (communication, social, restricted repetitive interests and behaviors), delayed language development, and symptom onset prior to age 3 years. [url:http\\://en.wikipedia.org/wiki/Autism, url:http\\://www.neurodevnet.ca]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene SERTAD3?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "SERTAD3", "name": "SERTA domain containing 3" }, "MidAttributes": { "id": "Q9UJW9", "name": "SERTAD3" }, "answer": [ { "answer": "cancer", "description": "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis. [url:http\\://en.wikipedia.org/wiki/cancer, url:http\\://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=cancer]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene KRTAP19-6?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "KRTAP19-6", "name": "keratin associated protein 19-6" }, "MidAttributes": { "id": "Q3LI70", "name": "KRTAP19-6" }, "answer": [ { "answer": "retinitis pigmentosa 11", "description": "A retinitis pigmentosa that has_material_basis_in mutation in the PRPF31 gene on chromosome 19q13. [url:https\\://www.ncbi.nlm.nih.gov/pubmed/11545739]" }, { "answer": "chronic fatigue syndrome", "description": "A syndrome that involves prolonged and severe tiredness or weariness that is unrelated to exertion, is not relieved by rest and for a minimum of six months and is not directly caused by other conditions. [url:http\\://en.wikipedia.org/wiki/Chronic_fatigue_syndrome]" }, { "answer": "retinitis pigmentosa", "description": "A retinal degeneration characterized by the gradual deterioration of the photoreceptors or the retinal pigment epithelium of the retina leading to progressive sight loss. [url:http\\://en.wikipedia.org/wiki/Retinitis_pigmentosa, url:http\\://ghr.nlm.nih.gov/condition/retinitis-pigmentosa, url:http\\://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043609/, url:https\\://www.genome.gov/Genetic-Disorders/Retinitis-Pigmentosa]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene ZNF121?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "ZNF121", "name": "zinc finger protein 121" }, "MidAttributes": { "id": "P58317", "name": "ZNF121" }, "answer": [ { "answer": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland. [url:http\\://en.wikipedia.org/wiki/Breast_cancer, url:http\\://en.wikipedia.org/wiki/Mammary, url:http\\://www.cancer.gov/cancertopics/types/breast, url:http\\://www.nlm.nih.gov/medlineplus/breastcancer.html, url:https\\://www.genome.gov/Genetic-Disorders/Breast-Cancer]" }, { "answer": "luminal breast carcinoma A", "description": "A breast carcinoma that is characterized by high expression of genes characteristic of luminal epithelial cells, including estrogen receptor (ER), estrogen regulated protein LIV-1, and the transcription factors hepatocyte nuclear factor 3, HNF3A, XBP1, and GATA 3. [url:https\\://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167319/]" }, { "answer": "breast carcinoma", "description": "A breast cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. [url:http\\://en.wikipedia.org/wiki/Breast_cancer]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene OR2J3?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "OR2J3", "name": "olfactory receptor family 2 subfamily J member 3" }, "MidAttributes": { "id": "O76001", "name": "OR2J3" }, "answer": [ { "answer": "lung non-small cell carcinoma", "description": "A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma. [url:http\\://en.wikipedia.org/wiki/Non-small-cell_lung_carcinoma]" }, { "answer": "lung cancer", "description": "A respiratory system cancer that is located_in the lung. [url:http\\://en.wikipedia.org/wiki/Lung_cancer]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene TTC34?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "TTC34", "name": "tetratricopeptide repeat domain 34" }, "MidAttributes": { "id": "A8MYJ7", "name": "TTC34" }, "answer": [ { "answer": "lupus nephritis", "description": "A glomerulonephritis that is characterized by inflammation of the kidneys resulting from systemic lupus erythematosus. [url:https\\://en.wikipedia.org/wiki/Lupus_nephritis#cite_note-1, url:https\\://medlineplus.gov/ency/article/000481.htm]" }, { "answer": "systemic lupus erythematosus", "description": "A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart. [url:http\\://en.wikipedia.org/wiki/Systemic_lupus_erythematosus]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene SPATA31A5?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "SPATA31A5", "name": "SPATA31 subfamily A member 5" }, "MidAttributes": { "id": "Q5VU36", "name": "SPATA31A5" }, "answer": [ { "answer": "rectum cancer", "description": "A colorectal cancer that is located_in the rectum. [url:http\\://www.cancer.gov/dictionary?CdrID=529764]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene PNISR?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "PNISR", "name": "PNN interacting serine and arginine rich protein" }, "MidAttributes": { "id": "Q8TF01", "name": "PNISR" }, "answer": [ { "answer": "psoriasis", "description": "A skin disease that is characterized by patches of thick red skin and silvery scales. [url:https\\://www.cdc.gov/psoriasis/index.htm]" }, { "answer": "pustulosis of palm and sole", "description": "pustulosis of palm and sole" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene EPB41L2?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "EPB41L2", "name": "erythrocyte membrane protein band 4.1 like 2" }, "MidAttributes": { "id": "O43491", "name": "EPB41L2" }, "answer": [ { "answer": "breast carcinoma", "description": "A breast cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. [url:http\\://en.wikipedia.org/wiki/Breast_cancer]" }, { "answer": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland. [url:http\\://en.wikipedia.org/wiki/Breast_cancer, url:http\\://en.wikipedia.org/wiki/Mammary, url:http\\://www.cancer.gov/cancertopics/types/breast, url:http\\://www.nlm.nih.gov/medlineplus/breastcancer.html, url:https\\://www.genome.gov/Genetic-Disorders/Breast-Cancer]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene SMIM17?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "SMIM17", "name": "small integral membrane protein 17" }, "MidAttributes": { "id": "P0DL12", "name": "SMIM17" }, "answer": [ { "answer": "muscular atrophy", "description": "muscular atrophy" }, { "answer": "autistic disorder", "description": "An autism spectrum disorder that is characterized by symptoms across all three symptom domains (communication, social, restricted repetitive interests and behaviors), delayed language development, and symptom onset prior to age 3 years. [url:http\\://en.wikipedia.org/wiki/Autism, url:http\\://www.neurodevnet.ca]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene PODNL1?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "PODNL1", "name": "podocan like 1" }, "MidAttributes": { "id": "Q6PEZ8", "name": "PODNL1" }, "answer": [ { "answer": "fundus dystrophy", "description": "fundus dystrophy" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene MED29?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "MED29", "name": "mediator complex subunit 29" }, "MidAttributes": { "id": "Q9NX70", "name": "MED29" }, "answer": [ { "answer": "cancer", "description": "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis. [url:http\\://en.wikipedia.org/wiki/cancer, url:http\\://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=cancer]" }, { "answer": "pancreatic carcinoma", "description": "A pancreas cancer that derives_from epithelial cells located_in the exocrine pancreas. [url:http\\://en.wikipedia.org/wiki/Carcinoma, url:http\\://www.cancer.gov/cancertopics/types/pancreatic]" }, { "answer": "pancreatic cancer", "description": "An endocrine gland cancer located_in the pancreas. [url:http\\://en.wikipedia.org/wiki/Pancreatic]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene ZFAND6?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "ZFAND6", "name": "zinc finger AN1-type containing 6" }, "MidAttributes": { "id": "Q6FIF0", "name": "ZFAND6" }, "answer": [ { "answer": "skin disease", "description": "An integumentary system disease that is located_in skin. [url:http\\://en.wikipedia.org/wiki/Skin_disease]" }, { "answer": "type 2 diabetes mellitus", "description": "A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. [url:http\\://en.wikipedia.org/wiki/Diabetes, url:http\\://en.wikipedia.org/wiki/Diabetes_mellitus_type_2]" } ], "type": "multi-hop" }, { "question": "What diseases are associated with the protein encoded by the gene SLC45A1?", "InitialType": "Gene", "MidType": "Protein", "FinalType": "Disease", "EdgeTypes": [ "TRANSLATED_INTO", "ASSOCIATED_WITH" ], "InitialAttributes": { "id": "SLC45A1", "name": "solute carrier family 45 member 1" }, "MidAttributes": { "id": "Q9Y2W3", "name": "SLC45A1" }, "answer": [ { "answer": "intellectual disability", "description": "A specific developmental disorder that involves significant limitations both in mental functioning and in adaptive behavior such as communicating, taking care of him or herself, and social skills. [url:http\\://aaidd.org/intellectual-disability/definition#.WsPDT2VvqaU, url:https\\://en.wikipedia.org/wiki/Intellectual_disability]" }, { "answer": "neuroblastoma", "description": "An autonomic nervous system neoplasm that derives_from immature nerve cells. [url:http\\://www.cancer.gov/cancertopics/types/neuroblastoma]" }, { "answer": "epilepsy", "description": "A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions. [url:http\\://books.google.com/books?id=YXqX04Te9ioC&printsec=frontcover&source=gbs_ge_summary_r&cad=0#v=onepage&q&f=false, url:http\\://www.merriam-webster.com/medlineplus/epilepsy]" }, { "answer": "learning disability", "description": "A specific developmental disorder that involves difficulty in scholastic skills such as reading, writing, spelling, reasoning, recalling and/or organizing information resulting from the brain's inability to receive and process information. [url:http\\://en.wikipedia.org/wiki/Learning_disability, url:http\\://www.ldonline.org/ldbasics/whatisld]" } ], "type": "multi-hop" }, { "question": "Which biological process are the proteins P46087 and P62750 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Biological_process", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "P46087" }, "Entity2Attributes": { "id": "P62750" }, "answer": [ { "answer": "ribosomal large subunit assembly", "description": "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. [GOC:jl, PMID:30467428]", "id": "GO:0000027" } ], "type": "conjunction" }, { "question": "Which biological process are the proteins Q15050 and P83731 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Biological_process", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "Q15050" }, "Entity2Attributes": { "id": "P83731" }, "answer": [ { "answer": "ribosomal large subunit assembly", "description": "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. [GOC:jl, PMID:30467428]", "id": "GO:0000027" } ], "type": "conjunction" }, { "question": "Which biological process are the proteins Q8TDN6 and P42677 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Biological_process", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "Q8TDN6" }, "Entity2Attributes": { "id": "P42677" }, "answer": [ { "answer": "rRNA processing", "description": "Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. [GOC:curators]", "id": "GO:0006364" } ], "type": "conjunction" }, { "question": "Which biological process are the proteins Q6Q0C0 and Q9BYC9 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Biological_process", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "Q6Q0C0" }, "Entity2Attributes": { "id": "Q9BYC9" }, "answer": [ { "answer": "ribosomal large subunit assembly", "description": "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. [GOC:jl, PMID:30467428]", "id": "GO:0000027" } ], "type": "conjunction" }, { "question": "Which biological process are the proteins Q8NHW5 and Q8TDN6 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Biological_process", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "Q8NHW5" }, "Entity2Attributes": { "id": "Q8TDN6" }, "answer": [ { "answer": "ribosomal large subunit assembly", "description": "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. [GOC:jl, PMID:30467428]", "id": "GO:0000027" } ], "type": "conjunction" }, { "question": "Which biological process are the proteins P42677 and P62263 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Biological_process", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "P42677" }, "Entity2Attributes": { "id": "P62263" }, "answer": [ { "answer": "ribosomal small subunit assembly", "description": "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit. [GOC:jl, PMID:30467428]", "id": "GO:0000028" }, { "answer": "translation", "description": "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. [GOC:go_curators]", "id": "GO:0006412" }, { "answer": "cytoplasmic translation", "description": "The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein. [GOC:hjd]", "id": "GO:0002181" }, { "answer": "ribosomal small subunit biogenesis", "description": "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis. [GOC:jl]", "id": "GO:0042274" } ], "type": "conjunction" }, { "question": "Which biological process are the proteins P19971 and Q96CQ1 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Biological_process", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "P19971" }, "Entity2Attributes": { "id": "Q96CQ1" }, "answer": [ { "answer": "mitochondrial genome maintenance", "description": "The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome. [GOC:ai, GOC:vw]", "id": "GO:0000002" } ], "type": "conjunction" }, { "question": "Which biological process are the proteins Q02878 and P62857 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Biological_process", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "Q02878" }, "Entity2Attributes": { "id": "P62857" }, "answer": [ { "answer": "cytoplasmic translation", "description": "The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein. [GOC:hjd]", "id": "GO:0002181" }, { "answer": "translation", "description": "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. [GOC:go_curators]", "id": "GO:0006412" } ], "type": "conjunction" }, { "question": "Which biological process are the proteins Q96L21 and Q02878 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Biological_process", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "Q96L21" }, "Entity2Attributes": { "id": "Q02878" }, "answer": [ { "answer": "ribosomal large subunit assembly", "description": "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. [GOC:jl, PMID:30467428]", "id": "GO:0000027" }, { "answer": "translation", "description": "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. [GOC:go_curators]", "id": "GO:0006412" } ], "type": "conjunction" }, { "question": "Which biological process are the proteins Q9H611 and Q8IW19 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Biological_process", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "Q9H611" }, "Entity2Attributes": { "id": "Q8IW19" }, "answer": [ { "answer": "DNA repair", "description": "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. [PMID:11563486]", "id": "GO:0006281" } ], "type": "conjunction" }, { "question": "Which biological process are the proteins Q96L21 and Q9Y2R9 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Biological_process", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "Q96L21" }, "Entity2Attributes": { "id": "Q9Y2R9" }, "answer": [ { "answer": "translation", "description": "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. [GOC:go_curators]", "id": "GO:0006412" } ], "type": "conjunction" }, { "question": "Which biological process are the proteins O75616 and P62857 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Biological_process", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "O75616" }, "Entity2Attributes": { "id": "P62857" }, "answer": [ { "answer": "ribosomal small subunit assembly", "description": "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit. [GOC:jl, PMID:30467428]", "id": "GO:0000028" } ], "type": "conjunction" }, { "question": "Which biological process are the proteins P46087 and P05388 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Biological_process", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "P46087" }, "Entity2Attributes": { "id": "P05388" }, "answer": [ { "answer": "ribosomal large subunit assembly", "description": "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. [GOC:jl, PMID:30467428]", "id": "GO:0000027" } ], "type": "conjunction" }, { "question": "Which biological process are the proteins Q9BYC9 and P83731 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Biological_process", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "Q9BYC9" }, "Entity2Attributes": { "id": "P83731" }, "answer": [ { "answer": "ribosomal large subunit assembly", "description": "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. [GOC:jl, PMID:30467428]", "id": "GO:0000027" } ], "type": "conjunction" }, { "question": "Which biological process are the proteins P09430 and Q9H4L7 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Biological_process", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "P09430" }, "Entity2Attributes": { "id": "Q9H4L7" }, "answer": [ { "answer": "chromatin remodeling", "description": "A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]", "id": "GO:0006338" } ], "type": "conjunction" }, { "question": "Which biological process are the proteins Q9NU22 and P83731 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Biological_process", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "Q9NU22" }, "Entity2Attributes": { "id": "P83731" }, "answer": [ { "answer": "ribosomal large subunit assembly", "description": "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. [GOC:jl, PMID:30467428]", "id": "GO:0000027" } ], "type": "conjunction" }, { "question": "Which biological process are the proteins Q8NHW5 and Q14137 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Biological_process", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "Q8NHW5" }, "Entity2Attributes": { "id": "Q14137" }, "answer": [ { "answer": "ribosomal large subunit assembly", "description": "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. [GOC:jl, PMID:30467428]", "id": "GO:0000027" }, { "answer": "ribosome biogenesis", "description": "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis. [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]", "id": "GO:0042254" } ], "type": "conjunction" }, { "question": "Which biological process are the proteins Q14137 and Q02878 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Biological_process", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "Q14137" }, "Entity2Attributes": { "id": "Q02878" }, "answer": [ { "answer": "ribosomal large subunit assembly", "description": "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. [GOC:jl, PMID:30467428]", "id": "GO:0000027" } ], "type": "conjunction" }, { "question": "Which biological process are the proteins P62750 and P62263 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Biological_process", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "P62750" }, "Entity2Attributes": { "id": "P62263" }, "answer": [ { "answer": "translation", "description": "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. [GOC:go_curators]", "id": "GO:0006412" }, { "answer": "cytoplasmic translation", "description": "The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein. [GOC:hjd]", "id": "GO:0002181" } ], "type": "conjunction" }, { "question": "Which biological process are the proteins P83731 and P62263 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Biological_process", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "P83731" }, "Entity2Attributes": { "id": "P62263" }, "answer": [ { "answer": "translation", "description": "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. [GOC:go_curators]", "id": "GO:0006412" }, { "answer": "cytoplasmic translation", "description": "The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein. [GOC:hjd]", "id": "GO:0002181" } ], "type": "conjunction" }, { "question": "Which biological process are the proteins Q9NUW8 and Q8IW19 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Biological_process", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "Q9NUW8" }, "Entity2Attributes": { "id": "Q8IW19" }, "answer": [ { "answer": "single strand break repair", "description": "The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair. [PMID:18626472]", "id": "GO:0000012" }, { "answer": "double-strand break repair", "description": "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. [GOC:elh]", "id": "GO:0006302" }, { "answer": "DNA repair", "description": "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. [PMID:11563486]", "id": "GO:0006281" } ], "type": "conjunction" }, { "question": "Which biological process are the proteins Q9NQ55 and P83731 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Biological_process", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "Q9NQ55" }, "Entity2Attributes": { "id": "P83731" }, "answer": [ { "answer": "ribosomal large subunit assembly", "description": "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. [GOC:jl, PMID:30467428]", "id": "GO:0000027" } ], "type": "conjunction" }, { "question": "Which biological process are the proteins P46777 and Q9NQ55 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Biological_process", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "P46777" }, "Entity2Attributes": { "id": "Q9NQ55" }, "answer": [ { "answer": "rRNA processing", "description": "Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. [GOC:curators]", "id": "GO:0006364" }, { "answer": "ribosomal large subunit assembly", "description": "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. [GOC:jl, PMID:30467428]", "id": "GO:0000027" } ], "type": "conjunction" }, { "question": "Which biological process are the proteins Q9NQ55 and P62750 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Biological_process", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "Q9NQ55" }, "Entity2Attributes": { "id": "P62750" }, "answer": [ { "answer": "ribosomal large subunit assembly", "description": "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. [GOC:jl, PMID:30467428]", "id": "GO:0000027" } ], "type": "conjunction" }, { "question": "Which biological process are the proteins Q9H7B2 and Q6Q0C0 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Biological_process", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "Q9H7B2" }, "Entity2Attributes": { "id": "Q6Q0C0" }, "answer": [ { "answer": "ribosomal large subunit assembly", "description": "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. [GOC:jl, PMID:30467428]", "id": "GO:0000027" } ], "type": "conjunction" }, { "question": "Which biological process are the proteins P52292 and Q96FV9 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Biological_process", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "P52292" }, "Entity2Attributes": { "id": "Q96FV9" }, "answer": [ { "answer": "regulation of DNA recombination", "description": "Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. [GOC:go_curators, ISBN:0198506732]", "id": "GO:0000018" } ], "type": "conjunction" }, { "question": "Which biological process are the proteins Q9NQ55 and P27635 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Biological_process", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "Q9NQ55" }, "Entity2Attributes": { "id": "P27635" }, "answer": [ { "answer": "ribosomal large subunit assembly", "description": "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. [GOC:jl, PMID:30467428]", "id": "GO:0000027" } ], "type": "conjunction" }, { "question": "Which biological process are the proteins P27635 and P62857 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Biological_process", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "P27635" }, "Entity2Attributes": { "id": "P62857" }, "answer": [ { "answer": "cytoplasmic translation", "description": "The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein. [GOC:hjd]", "id": "GO:0002181" }, { "answer": "translation", "description": "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. [GOC:go_curators]", "id": "GO:0006412" } ], "type": "conjunction" }, { "question": "Which pathway are the proteins P49841 and P31749 both annotated in?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Pathway", "EdgeType": "ANNOTATED_IN_PATHWAY", "Entity1Attributes": { "id": "P49841" }, "Entity2Attributes": { "id": "P31749" }, "answer": [ { "id": "R-HSA-5674400", "description": "Constitutive Signaling by AKT1 E17K in Cancer", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-5674400", "source": "Reactome", "answer": "Constitutive Signaling by AKT1 E17K in Cancer" } ], "type": "conjunction" }, { "question": "Which pathway are the proteins P08253 and P01148 both annotated in?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Pathway", "EdgeType": "ANNOTATED_IN_PATHWAY", "Entity1Attributes": { "id": "P08253" }, "Entity2Attributes": { "id": "P01148" }, "answer": [ { "id": "SMP0063811", "description": "Protein", "linkout": "http://smpdb.ca/view/SMP0063811", "source": "SMPDB", "answer": "GnRH Signaling Pathway" } ], "type": "conjunction" }, { "question": "Which pathway are the proteins O75015 and Q9Y315 both annotated in?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Pathway", "EdgeType": "ANNOTATED_IN_PATHWAY", "Entity1Attributes": { "id": "O75015" }, "Entity2Attributes": { "id": "Q9Y315" }, "answer": [ { "id": "R-HSA-6798695", "description": "Neutrophil degranulation", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-6798695", "source": "Reactome", "answer": "Neutrophil degranulation" } ], "type": "conjunction" }, { "question": "Which pathway are the proteins P31749 and P46734 both annotated in?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Pathway", "EdgeType": "ANNOTATED_IN_PATHWAY", "Entity1Attributes": { "id": "P31749" }, "Entity2Attributes": { "id": "P46734" }, "answer": [ { "id": "SMP0000358", "description": "Protein", "linkout": "http://smpdb.ca/view/SMP0000358", "source": "SMPDB", "answer": "Fc Epsilon Receptor I Signaling in Mast Cells" } ], "type": "conjunction" }, { "question": "Which pathway are the proteins P06307 and Q15147 both annotated in?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Pathway", "EdgeType": "ANNOTATED_IN_PATHWAY", "Entity1Attributes": { "id": "P06307" }, "Entity2Attributes": { "id": "Q15147" }, "answer": [ { "id": "R-HSA-416476", "description": "G alpha (q) signalling events", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-416476", "source": "Reactome", "answer": "G alpha (q) signalling events" } ], "type": "conjunction" }, { "question": "Which pathway are the proteins P01106 and Q00987 both annotated in?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Pathway", "EdgeType": "ANNOTATED_IN_PATHWAY", "Entity1Attributes": { "id": "P01106" }, "Entity2Attributes": { "id": "Q00987" }, "answer": [ { "id": "SMP0031697", "description": "Drug Action", "linkout": "http://smpdb.ca/view/SMP0031697", "source": "SMPDB", "answer": "Nilotinib Inhibition of BCR-ABL" } ], "type": "conjunction" }, { "question": "Which pathway are the proteins P02649 and Q9HAY6 both annotated in?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Pathway", "EdgeType": "ANNOTATED_IN_PATHWAY", "Entity1Attributes": { "id": "P02649" }, "Entity2Attributes": { "id": "Q9HAY6" }, "answer": [ { "id": "R-HSA-975634", "description": "Retinoid metabolism and transport", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-975634", "source": "Reactome", "answer": "Retinoid metabolism and transport" } ], "type": "conjunction" }, { "question": "Which pathway are the proteins P16220 and Q08462 both annotated in?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Pathway", "EdgeType": "ANNOTATED_IN_PATHWAY", "Entity1Attributes": { "id": "P16220" }, "Entity2Attributes": { "id": "Q08462" }, "answer": [ { "id": "SMP0000309", "description": "Protein", "linkout": "http://smpdb.ca/view/SMP0000309", "source": "SMPDB", "answer": "Excitatory Neural Signalling Through 5-HTR 4 and Serotonin" } ], "type": "conjunction" }, { "question": "Which pathway are the proteins P01730 and P01906 both annotated in?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Pathway", "EdgeType": "ANNOTATED_IN_PATHWAY", "Entity1Attributes": { "id": "P01730" }, "Entity2Attributes": { "id": "P01906" }, "answer": [ { "id": "R-HSA-202427", "description": "Phosphorylation of CD3 and TCR zeta chains", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-202427", "source": "Reactome", "answer": "Phosphorylation of CD3 and TCR zeta chains" } ], "type": "conjunction" }, { "question": "Which pathway are the proteins P15692 and O60245 both annotated in?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Pathway", "EdgeType": "ANNOTATED_IN_PATHWAY", "Entity1Attributes": { "id": "P15692" }, "Entity2Attributes": { "id": "O60245" }, "answer": [ { "id": "R-HSA-114608", "description": "Platelet degranulation ", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-114608", "source": "Reactome", "answer": "Platelet degranulation " } ], "type": "conjunction" }, { "question": "Which pathway are the proteins O75015 and Q9HD89 both annotated in?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Pathway", "EdgeType": "ANNOTATED_IN_PATHWAY", "Entity1Attributes": { "id": "O75015" }, "Entity2Attributes": { "id": "Q9HD89" }, "answer": [ { "id": "R-HSA-6798695", "description": "Neutrophil degranulation", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-6798695", "source": "Reactome", "answer": "Neutrophil degranulation" } ], "type": "conjunction" }, { "question": "Which pathway are the proteins P01562 and P05013 both annotated in?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Pathway", "EdgeType": "ANNOTATED_IN_PATHWAY", "Entity1Attributes": { "id": "P01562" }, "Entity2Attributes": { "id": "P05013" }, "answer": [ { "id": "R-HSA-912694", "description": "Regulation of IFNA/IFNB signaling", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-912694", "source": "Reactome", "answer": "Regulation of IFNA/IFNB signaling" } ], "type": "conjunction" }, { "question": "Which pathway are the proteins P60568 and Q99748 both annotated in?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Pathway", "EdgeType": "ANNOTATED_IN_PATHWAY", "Entity1Attributes": { "id": "P60568" }, "Entity2Attributes": { "id": "Q99748" }, "answer": [ { "id": "R-HSA-5673001", "description": "RAF/MAP kinase cascade", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-5673001", "source": "Reactome", "answer": "RAF/MAP kinase cascade" } ], "type": "conjunction" }, { "question": "Which pathway are the proteins P06307 and Q9NS75 both annotated in?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Pathway", "EdgeType": "ANNOTATED_IN_PATHWAY", "Entity1Attributes": { "id": "P06307" }, "Entity2Attributes": { "id": "Q9NS75" }, "answer": [ { "id": "R-HSA-416476", "description": "G alpha (q) signalling events", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-416476", "source": "Reactome", "answer": "G alpha (q) signalling events" } ], "type": "conjunction" }, { "question": "Which pathway are the proteins P01308 and P11168 both annotated in?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Pathway", "EdgeType": "ANNOTATED_IN_PATHWAY", "Entity1Attributes": { "id": "P01308" }, "Entity2Attributes": { "id": "P11168" }, "answer": [ { "id": "SMP0000643", "description": "Physiological", "linkout": "http://smpdb.ca/view/SMP0000643", "source": "SMPDB", "answer": "Pancreas Function" } ], "type": "conjunction" }, { "question": "Which pathway are the proteins P10145 and P01298 both annotated in?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Pathway", "EdgeType": "ANNOTATED_IN_PATHWAY", "Entity1Attributes": { "id": "P10145" }, "Entity2Attributes": { "id": "P01298" }, "answer": [ { "id": "R-HSA-418594", "description": "G alpha (i) signalling events", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-418594", "source": "Reactome", "answer": "G alpha (i) signalling events" } ], "type": "conjunction" }, { "question": "Which pathway are the proteins P02649 and P02652 both annotated in?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Pathway", "EdgeType": "ANNOTATED_IN_PATHWAY", "Entity1Attributes": { "id": "P02649" }, "Entity2Attributes": { "id": "P02652" }, "answer": [ { "id": "R-HSA-975634", "description": "Retinoid metabolism and transport", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-975634", "source": "Reactome", "answer": "Retinoid metabolism and transport" } ], "type": "conjunction" }, { "question": "Which pathway are the proteins P42574 and O43318 both annotated in?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Pathway", "EdgeType": "ANNOTATED_IN_PATHWAY", "Entity1Attributes": { "id": "P42574" }, "Entity2Attributes": { "id": "O43318" }, "answer": [ { "id": "SMP0069695", "description": "Protein", "linkout": "http://smpdb.ca/view/SMP0069695", "source": "SMPDB", "answer": "FAS signaling pathway ( CD95 )" } ], "type": "conjunction" }, { "question": "Which pathway are the proteins P09874 and P18858 both annotated in?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Pathway", "EdgeType": "ANNOTATED_IN_PATHWAY", "Entity1Attributes": { "id": "P09874" }, "Entity2Attributes": { "id": "P18858" }, "answer": [ { "id": "R-HSA-110362", "description": "POLB-Dependent Long Patch Base Excision Repair", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-110362", "source": "Reactome", "answer": "POLB-Dependent Long Patch Base Excision Repair" } ], "type": "conjunction" }, { "question": "Which pathway are the proteins P42081 and P42336 both annotated in?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Pathway", "EdgeType": "ANNOTATED_IN_PATHWAY", "Entity1Attributes": { "id": "P42081" }, "Entity2Attributes": { "id": "P42336" }, "answer": [ { "id": "R-HSA-389357", "description": "CD28 dependent PI3K/Akt signaling", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-389357", "source": "Reactome", "answer": "CD28 dependent PI3K/Akt signaling" } ], "type": "conjunction" }, { "question": "Which pathway are the proteins P42224 and P40763 both annotated in?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Pathway", "EdgeType": "ANNOTATED_IN_PATHWAY", "Entity1Attributes": { "id": "P42224" }, "Entity2Attributes": { "id": "P40763" }, "answer": [ { "id": "SMP0063810", "description": "Protein", "linkout": "http://smpdb.ca/view/SMP0063810", "source": "SMPDB", "answer": "EGF Signalling Pathway" } ], "type": "conjunction" }, { "question": "Which pathway are the proteins P14780 and Q9HD89 both annotated in?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Pathway", "EdgeType": "ANNOTATED_IN_PATHWAY", "Entity1Attributes": { "id": "P14780" }, "Entity2Attributes": { "id": "Q9HD89" }, "answer": [ { "id": "R-HSA-6798695", "description": "Neutrophil degranulation", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-6798695", "source": "Reactome", "answer": "Neutrophil degranulation" } ], "type": "conjunction" }, { "question": "Which pathway are the proteins P49841 and P43686 both annotated in?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Pathway", "EdgeType": "ANNOTATED_IN_PATHWAY", "Entity1Attributes": { "id": "P49841" }, "Entity2Attributes": { "id": "P43686" }, "answer": [ { "id": "R-HSA-8939902", "description": "Regulation of RUNX2 expression and activity", "linkout": "https://reactome.org/PathwayBrowser/#/R-HSA-8939902", "source": "Reactome", "answer": "Regulation of RUNX2 expression and activity" } ], "type": "conjunction" }, { "question": "What molecular function are the proteins Q16552 and O95760 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Molecular_function", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "Q16552" }, "Entity2Attributes": { "id": "O95760" }, "answer": [ { "description": "The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells. [ISBN:0198599471, PMID:11530802]", "answer": "cytokine activity" } ], "type": "conjunction" }, { "question": "What molecular function are the proteins P02649 and Q9UP65 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Molecular_function", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "P02649" }, "Entity2Attributes": { "id": "Q9UP65" }, "answer": [ { "description": "Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester. [ISBN:0198506732]", "answer": "phospholipid binding" } ], "type": "conjunction" }, { "question": "What molecular function are the proteins Q9NZQ7 and Q99967 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Molecular_function", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "Q9NZQ7" }, "Entity2Attributes": { "id": "Q99967" }, "answer": [ { "description": "Binding to a protein. [GOC:go_curators]", "answer": "protein binding" } ], "type": "conjunction" }, { "question": "What molecular function are the proteins P24385 and Q96I15 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Molecular_function", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "P24385" }, "Entity2Attributes": { "id": "Q96I15" }, "answer": [ { "description": "Binding to a protein. [GOC:go_curators]", "answer": "protein binding" } ], "type": "conjunction" }, { "question": "What molecular function are the proteins P42345 and Q15418 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Molecular_function", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "P42345" }, "Entity2Attributes": { "id": "Q15418" }, "answer": [ { "description": "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]", "answer": "protein serine/threonine kinase activity" } ], "type": "conjunction" }, { "question": "What molecular function are the proteins P05412 and O43829 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Molecular_function", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "P05412" }, "Entity2Attributes": { "id": "O43829" }, "answer": [ { "description": "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. [GOC:txnOH-2018]", "answer": "RNA polymerase II cis-regulatory region sequence-specific DNA binding" } ], "type": "conjunction" }, { "question": "What molecular function are the proteins P01133 and P08620 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Molecular_function", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "P01133" }, "Entity2Attributes": { "id": "P08620" }, "answer": [ { "description": "The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. [ISBN:0815316194]", "answer": "growth factor activity" } ], "type": "conjunction" }, { "question": "What molecular function are the proteins P04626 and P05023 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Molecular_function", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "P04626" }, "Entity2Attributes": { "id": "P05023" }, "answer": [ { "description": "Binding to a nonidentical protein to form a heterodimer. [GOC:ai]", "answer": "protein heterodimerization activity" } ], "type": "conjunction" }, { "question": "What molecular function are the proteins Q16695 and O95343 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Molecular_function", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "Q16695" }, "Entity2Attributes": { "id": "O95343" }, "answer": [ { "description": "Binding to a protein. [GOC:go_curators]", "answer": "protein binding" } ], "type": "conjunction" }, { "question": "What molecular function are the proteins P48431 and Q9H2J7 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Molecular_function", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "P48431" }, "Entity2Attributes": { "id": "Q9H2J7" }, "answer": [ { "description": "Binding to a protein. [GOC:go_curators]", "answer": "protein binding" } ], "type": "conjunction" }, { "question": "What molecular function are the proteins Q16552 and P09038 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Molecular_function", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "Q16552" }, "Entity2Attributes": { "id": "P09038" }, "answer": [ { "description": "The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells. [ISBN:0198599471, PMID:11530802]", "answer": "cytokine activity" } ], "type": "conjunction" }, { "question": "What molecular function are the proteins P04141 and P01241 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Molecular_function", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "P04141" }, "Entity2Attributes": { "id": "P01241" }, "answer": [ { "description": "The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. [ISBN:0815316194]", "answer": "growth factor activity" } ], "type": "conjunction" }, { "question": "What molecular function are the proteins P12830 and P02675 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Molecular_function", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "P12830" }, "Entity2Attributes": { "id": "P02675" }, "answer": [ { "description": "Binding to a cell adhesion molecule. [GOC:ai]", "answer": "cell adhesion molecule binding" } ], "type": "conjunction" }, { "question": "What molecular function are the proteins P01133 and Q5T4W7 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Molecular_function", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "P01133" }, "Entity2Attributes": { "id": "Q5T4W7" }, "answer": [ { "description": "The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. [ISBN:0815316194]", "answer": "growth factor activity" } ], "type": "conjunction" }, { "question": "What molecular function are the proteins O00206 and Q8N6F1 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Molecular_function", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "O00206" }, "Entity2Attributes": { "id": "Q8N6F1" }, "answer": [ { "description": "Binding to an identical protein or proteins. [GOC:jl]", "answer": "identical protein binding" } ], "type": "conjunction" }, { "question": "What molecular function are the proteins P16284 and Q9Y624 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Molecular_function", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "P16284" }, "Entity2Attributes": { "id": "Q9Y624" }, "answer": [ { "description": "Binding to an identical protein to form a homodimer. [GOC:jl]", "answer": "protein homodimerization activity" } ], "type": "conjunction" }, { "question": "What molecular function are the proteins P05113 and Q96NB1 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Molecular_function", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "P05113" }, "Entity2Attributes": { "id": "Q96NB1" }, "answer": [ { "description": "Binding to a protein. [GOC:go_curators]", "answer": "protein binding" } ], "type": "conjunction" }, { "question": "What molecular function are the proteins P35222 and Q9P2D0 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Molecular_function", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "P35222" }, "Entity2Attributes": { "id": "Q9P2D0" }, "answer": [ { "description": "Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl]", "answer": "protein kinase binding" } ], "type": "conjunction" }, { "question": "What molecular function are the proteins P05019 and Q8WUA7 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Molecular_function", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "P05019" }, "Entity2Attributes": { "id": "Q8WUA7" }, "answer": [ { "description": "Binding to a protein. [GOC:go_curators]", "answer": "protein binding" } ], "type": "conjunction" }, { "question": "What molecular function are the proteins Q14116 and P05014 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Molecular_function", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "Q14116" }, "Entity2Attributes": { "id": "P05014" }, "answer": [ { "description": "The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells. [ISBN:0198599471, PMID:11530802]", "answer": "cytokine activity" } ], "type": "conjunction" }, { "question": "What molecular function are the proteins P42771 and Q49AR2 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Molecular_function", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "P42771" }, "Entity2Attributes": { "id": "Q49AR2" }, "answer": [ { "description": "Binding to a protein. [GOC:go_curators]", "answer": "protein binding" } ], "type": "conjunction" }, { "question": "What molecular function are the proteins P09038 and P13796 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Molecular_function", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "P09038" }, "Entity2Attributes": { "id": "P13796" }, "answer": [ { "description": "Binding to an integrin. [GOC:ceb]", "answer": "integrin binding" } ], "type": "conjunction" }, { "question": "What molecular function are the proteins P12830 and P78310 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Molecular_function", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "P12830" }, "Entity2Attributes": { "id": "P78310" }, "answer": [ { "description": "Binding to a cell adhesion molecule. [GOC:ai]", "answer": "cell adhesion molecule binding" } ], "type": "conjunction" }, { "question": "Which disease are the proteins Q9UG56 and O75122 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Disease", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "Q9UG56" }, "Entity2Attributes": { "id": "O75122" }, "answer": [ { "answer": "cancer", "description": "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis. [url:http\\://en.wikipedia.org/wiki/cancer, url:http\\://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=cancer]", "id": "DOID:162" }, { "answer": "intellectual disability", "description": "A specific developmental disorder that involves significant limitations both in mental functioning and in adaptive behavior such as communicating, taking care of him or herself, and social skills. [url:http\\://aaidd.org/intellectual-disability/definition#.WsPDT2VvqaU, url:https\\://en.wikipedia.org/wiki/Intellectual_disability]", "id": "DOID:1059" }, { "answer": "learning disability", "description": "A specific developmental disorder that involves difficulty in scholastic skills such as reading, writing, spelling, reasoning, recalling and/or organizing information resulting from the brain's inability to receive and process information. [url:http\\://en.wikipedia.org/wiki/Learning_disability, url:http\\://www.ldonline.org/ldbasics/whatisld]", "id": "DOID:8927" } ], "type": "conjunction" }, { "question": "Which disease are the proteins O75122 and P05387 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Disease", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "O75122" }, "Entity2Attributes": { "id": "P05387" }, "answer": [ { "answer": "cancer", "description": "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis. [url:http\\://en.wikipedia.org/wiki/cancer, url:http\\://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=cancer]", "id": "DOID:162" } ], "type": "conjunction" }, { "question": "Which disease are the proteins P50150 and P13667 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Disease", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "P50150" }, "Entity2Attributes": { "id": "P13667" }, "answer": [ { "answer": "embryoma", "description": "A carcinosarcoma and embryonal cancer that is located_in embryonic tissue and results_in a mass of rapidly growing cells. [url:http\\://en.wikipedia.org/wiki/Embryoma]", "id": "DOID:4766" }, { "answer": "cancer", "description": "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis. [url:http\\://en.wikipedia.org/wiki/cancer, url:http\\://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=cancer]", "id": "DOID:162" } ], "type": "conjunction" }, { "question": "Which disease are the proteins Q674R7 and O14607 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Disease", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "Q674R7" }, "Entity2Attributes": { "id": "O14607" }, "answer": [ { "answer": "renal cell carcinoma", "description": "A renal carcinoma that has_material_basis_in the lining of the proximal convoluted renal tubule of the kidney. [url:http\\://en.wikipedia.org/wiki/Renal_cell_carcinoma, url:http\\://www.cancer.gov/dictionary?CdrID=661352]", "id": "DOID:4450" }, { "answer": "nonpapillary renal cell carcinoma", "description": "A hereditary renal cell carcinoma that has_material_basis_in a loss of 3p13-pter sequences. [url:https\\://www.ncbi.nlm.nih.gov/pubmed/2921777, url:https\\://www.ncbi.nlm.nih.gov/pubmed/8415591]", "id": "DOID:0050387" }, { "answer": "clear cell renal cell carcinoma", "description": "A renal cell carcinoma that has_material_basis_in cells that appear very pale or clear when examined under microscope. [url:http\\://www.cancer.gov/dictionary?CdrID=45063, url:https\\://cancergenome.nih.gov/cancersselected/kidneyclearcell]", "id": "DOID:4467" } ], "type": "conjunction" }, { "question": "Which disease are the proteins O14607 and A8MYZ5 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Disease", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "O14607" }, "Entity2Attributes": { "id": "A8MYZ5" }, "answer": [ { "answer": "cancer", "description": "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis. [url:http\\://en.wikipedia.org/wiki/cancer, url:http\\://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=cancer]", "id": "DOID:162" } ], "type": "conjunction" }, { "question": "Which disease are the proteins Q99766 and O14607 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Disease", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "Q99766" }, "Entity2Attributes": { "id": "O14607" }, "answer": [ { "answer": "renal cell carcinoma", "description": "A renal carcinoma that has_material_basis_in the lining of the proximal convoluted renal tubule of the kidney. [url:http\\://en.wikipedia.org/wiki/Renal_cell_carcinoma, url:http\\://www.cancer.gov/dictionary?CdrID=661352]", "id": "DOID:4450" }, { "answer": "nonpapillary renal cell carcinoma", "description": "A hereditary renal cell carcinoma that has_material_basis_in a loss of 3p13-pter sequences. [url:https\\://www.ncbi.nlm.nih.gov/pubmed/2921777, url:https\\://www.ncbi.nlm.nih.gov/pubmed/8415591]", "id": "DOID:0050387" }, { "answer": "clear cell renal cell carcinoma", "description": "A renal cell carcinoma that has_material_basis_in cells that appear very pale or clear when examined under microscope. [url:http\\://www.cancer.gov/dictionary?CdrID=45063, url:https\\://cancergenome.nih.gov/cancersselected/kidneyclearcell]", "id": "DOID:4467" } ], "type": "conjunction" }, { "question": "Which disease are the proteins Q8NH40 and O75122 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Disease", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "Q8NH40" }, "Entity2Attributes": { "id": "O75122" }, "answer": [ { "answer": "familial adenomatous polyposis", "description": "An intestinal disease that has_material_basis_in mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer. [url:http\\://en.wikipedia.org/wiki/Familial_adenomatous_polyposis, url:http\\://www.omim.org/entry/175100?search=adenomatous%20polyposis]", "id": "DOID:0050424" } ], "type": "conjunction" }, { "question": "Which disease are the proteins Q9NYQ3 and Q8TDZ2 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Disease", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "Q9NYQ3" }, "Entity2Attributes": { "id": "Q8TDZ2" }, "answer": [ { "answer": "embryoma", "description": "A carcinosarcoma and embryonal cancer that is located_in embryonic tissue and results_in a mass of rapidly growing cells. [url:http\\://en.wikipedia.org/wiki/Embryoma]", "id": "DOID:4766" }, { "answer": "cancer", "description": "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis. [url:http\\://en.wikipedia.org/wiki/cancer, url:http\\://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=cancer]", "id": "DOID:162" } ], "type": "conjunction" }, { "question": "Which disease are the proteins A6NGZ8 and O75122 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Disease", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "A6NGZ8" }, "Entity2Attributes": { "id": "O75122" }, "answer": [ { "answer": "intellectual disability", "description": "A specific developmental disorder that involves significant limitations both in mental functioning and in adaptive behavior such as communicating, taking care of him or herself, and social skills. [url:http\\://aaidd.org/intellectual-disability/definition#.WsPDT2VvqaU, url:https\\://en.wikipedia.org/wiki/Intellectual_disability]", "id": "DOID:1059" } ], "type": "conjunction" }, { "question": "Which disease are the proteins P0CI26 and Q9H2D6 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Disease", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "P0CI26" }, "Entity2Attributes": { "id": "Q9H2D6" }, "answer": [ { "answer": "cancer", "description": "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis. [url:http\\://en.wikipedia.org/wiki/cancer, url:http\\://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=cancer]", "id": "DOID:162" } ], "type": "conjunction" }, { "question": "Which disease are the proteins Q30KP8 and P0C2W7 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Disease", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "Q30KP8" }, "Entity2Attributes": { "id": "P0C2W7" }, "answer": [ { "answer": "heart disease", "description": "A cardiovascular system disease that involves the heart. [url:http\\://en.wikipedia.org/wiki/Heart_disease]", "id": "DOID:114" } ], "type": "conjunction" }, { "question": "Which disease are the proteins H3BPM6 and Q3LI64 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Disease", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "H3BPM6" }, "Entity2Attributes": { "id": "Q3LI64" }, "answer": [ { "answer": "genetic disease", "description": "A disease that has_material_basis_in genetic variations in the human genome. [url:http\\://ghr.nlm.nih.gov/]", "id": "DOID:630" } ], "type": "conjunction" }, { "question": "Which disease are the proteins H3BPM6 and P60372 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Disease", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "H3BPM6" }, "Entity2Attributes": { "id": "P60372" }, "answer": [ { "answer": "disease of anatomical entity", "description": "A disease that manifests in a defined anatomical structure. [url:http\\://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=anatomic]", "id": "DOID:7" }, { "answer": "lung disease", "description": "A lower respiratory tract disease in which the function of the lungs is adversely affected by narrowing or blockage of the airways resulting in poor air flow, a loss of elasticity in the lungs that produces a decrease in the total volume of air that the lungs are able to hold, and clotting, scarring, or inflammation of the blood vessels that affect the ability of the lungs to take up oxygen and to release carbon dioxide. [url:http\\://www.niehs.nih.gov/health/topics/conditions/lung-disease/index.cfm, url:http\\://www.nlm.nih.gov/medlineplus/ency/article/000066.htm]", "id": "DOID:850" }, { "answer": "lower respiratory tract disease", "description": "A respiratory system disease which involves the lower respiratory tract. [url:http\\://en.wikipedia.org/wiki/lower_respiratory_tract]", "id": "DOID:0050161" }, { "answer": "respiratory system disease", "description": "A disease of anatomical entity that located_in the respiratory system which extends from the nasal sinuses to the diaphragm. [url:http\\://en.wikipedia.org/wiki/File\\:Respiratory_system_complete_en.svg, url:http\\://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=respiratory%20system]", "id": "DOID:1579" } ], "type": "conjunction" }, { "question": "Which disease are the proteins Q0ZLH3 and P0C2W7 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Disease", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "Q0ZLH3" }, "Entity2Attributes": { "id": "P0C2W7" }, "answer": [ { "answer": "sensorineural hearing loss", "description": "An inner ear disease that is characterized by hearing loss resulting from damage to the cochlea, auditory nerve and/or brainstem. [url:https\\://medlineplus.gov/ency/article/003291.htm]", "id": "DOID:10003" } ], "type": "conjunction" }, { "question": "Which disease are the proteins Q13117 and O14599 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Disease", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "Q13117" }, "Entity2Attributes": { "id": "O14599" }, "answer": [ { "answer": "X-linked spermatogenic failure 1", "description": "A Sertoli cell-only syndrome characterized by X-linked inheritance. [url:https\\://www.ncbi.nlm.nih.gov/pubmed/10507722]", "id": "DOID:0070189" }, { "answer": "Y-linked spermatogenic failure 1", "description": "A Sertoli cell-only syndrome that has_material_basis_in deletions in the Yq11 chromosomal region. [url:https\\://www.ncbi.nlm.nih.gov/pubmed/2603934]", "id": "DOID:0070186" }, { "answer": "Sertoli cell-only syndrome", "description": "A male infertility disease characterized by male sterility, has_material_basis_in azospermia without abnormal sexual development. [url:https\\://rarediseases.info.nih.gov/diseases/8406/sertoli-cell-only-syndrome]", "id": "DOID:0050457" }, { "answer": "male infertility", "description": "male infertility", "id": "DOID:12336" }, { "answer": "oligospermia", "description": "A male fertility issue defined as a low sperm concentration in the ejaculate. [url:https\\://en.wikipedia.org/wiki/Oligospermia]", "id": "DOID:14228" }, { "answer": "Y-linked spermatogenic failure 2", "description": "A spermatogenic failure that is characterized by nonobstroctive azoospermia or oligozoospermia that has_material_basis_in interstitial deletions on the Yq11.221 chromosomal region. [url:https\\://www.ncbi.nlm.nih.gov/pubmed/19737515]", "id": "DOID:0070187" } ], "type": "conjunction" }, { "question": "Which disease are the proteins Q8NH67 and Q96FJ0 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Disease", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "Q8NH67" }, "Entity2Attributes": { "id": "Q96FJ0" }, "answer": [ { "answer": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach. [url:http\\://cancergenome.nih.gov/cancersselected/stomach-esophagealcancer, url:http\\://en.wikipedia.org/wiki/Stomach]", "id": "DOID:10534" } ], "type": "conjunction" }, { "question": "Which disease are the proteins Q96LB4 and Q8TEW6 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Disease", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "Q96LB4" }, "Entity2Attributes": { "id": "Q8TEW6" }, "answer": [ { "answer": "nonpapillary renal cell carcinoma", "description": "A hereditary renal cell carcinoma that has_material_basis_in a loss of 3p13-pter sequences. [url:https\\://www.ncbi.nlm.nih.gov/pubmed/2921777, url:https\\://www.ncbi.nlm.nih.gov/pubmed/8415591]", "id": "DOID:0050387" }, { "answer": "clear cell renal cell carcinoma", "description": "A renal cell carcinoma that has_material_basis_in cells that appear very pale or clear when examined under microscope. [url:http\\://www.cancer.gov/dictionary?CdrID=45063, url:https\\://cancergenome.nih.gov/cancersselected/kidneyclearcell]", "id": "DOID:4467" }, { "answer": "renal cell carcinoma", "description": "A renal carcinoma that has_material_basis_in the lining of the proximal convoluted renal tubule of the kidney. [url:http\\://en.wikipedia.org/wiki/Renal_cell_carcinoma, url:http\\://www.cancer.gov/dictionary?CdrID=661352]", "id": "DOID:4450" } ], "type": "conjunction" }, { "question": "Which disease are the proteins O14599 and Q9Y3B8 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Disease", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "O14599" }, "Entity2Attributes": { "id": "Q9Y3B8" }, "answer": [ { "answer": "lung adenocarcinoma", "description": "A lung non-small cell carcinoma that derives_from epithelial cells of glandular origin. [url:http\\://cancergenome.nih.gov/cancersselected/lungadenocarcinoma, url:http\\://en.wikipedia.org/wiki/Adenocarcinoma, url:http\\://en.wikipedia.org/wiki/Adenocarcinoma_of_the_lung]", "id": "DOID:3910" }, { "answer": "lung cancer", "description": "A respiratory system cancer that is located_in the lung. [url:http\\://en.wikipedia.org/wiki/Lung_cancer]", "id": "DOID:1324" } ], "type": "conjunction" }, { "question": "Which disease are the proteins Q8NH55 and Q9NXG2 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Disease", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "Q8NH55" }, "Entity2Attributes": { "id": "Q9NXG2" }, "answer": [ { "answer": "cancer", "description": "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis. [url:http\\://en.wikipedia.org/wiki/cancer, url:http\\://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=cancer]", "id": "DOID:162" } ], "type": "conjunction" }, { "question": "Which disease are the proteins A0A0A6YYJ9 and P59535 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Disease", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "A0A0A6YYJ9" }, "Entity2Attributes": { "id": "P59535" }, "answer": [ { "answer": "disease of metabolism", "description": "A disease that involving errors in metabolic processes of building or degradation of molecules. [url:http\\://www.ncbi.nlm.nih.gov/books/NBK22259/]", "id": "DOID:0014667" } ], "type": "conjunction" }, { "question": "Which disease are the proteins Q9H1X1 and Q3LI60 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Disease", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "Q9H1X1" }, "Entity2Attributes": { "id": "Q3LI60" }, "answer": [ { "answer": "lung disease", "description": "A lower respiratory tract disease in which the function of the lungs is adversely affected by narrowing or blockage of the airways resulting in poor air flow, a loss of elasticity in the lungs that produces a decrease in the total volume of air that the lungs are able to hold, and clotting, scarring, or inflammation of the blood vessels that affect the ability of the lungs to take up oxygen and to release carbon dioxide. [url:http\\://www.niehs.nih.gov/health/topics/conditions/lung-disease/index.cfm, url:http\\://www.nlm.nih.gov/medlineplus/ency/article/000066.htm]", "id": "DOID:850" } ], "type": "conjunction" }, { "question": "Which disease are the proteins A6NGZ8 and A8MZG2 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Disease", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "A6NGZ8" }, "Entity2Attributes": { "id": "A8MZG2" }, "answer": [ { "answer": "developmental disorder of mental health", "description": "A disease of mental health that occur during a child's developmental period between birth and age 18 resulting in retarding of the child's psychological or physical development. [url:http\\://en.wikipedia.org/wiki/Developmental_disorders]", "id": "DOID:0060037" }, { "answer": "specific developmental disorder", "description": "A developmental disorder of mental health that categorizes specific learning disabilities and developmental disorders affecting coordination. [url:http\\://en.wikipedia.org/wiki/Specific_developmental_disorder]", "id": "DOID:0060038" }, { "answer": "intellectual disability", "description": "A specific developmental disorder that involves significant limitations both in mental functioning and in adaptive behavior such as communicating, taking care of him or herself, and social skills. [url:http\\://aaidd.org/intellectual-disability/definition#.WsPDT2VvqaU, url:https\\://en.wikipedia.org/wiki/Intellectual_disability]", "id": "DOID:1059" }, { "answer": "disease of mental health", "description": "A disease that involves a psychological or behavioral pattern generally associated with subjective distress or disability that occurs in an individual, and which are not a part of normal development or culture. [url:http\\://en.wikipedia.org/wiki/Mental_disorder]", "id": "DOID:150" } ], "type": "conjunction" }, { "question": "Which disease are the proteins P0C2W7 and Q8TDZ2 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Disease", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "P0C2W7" }, "Entity2Attributes": { "id": "Q8TDZ2" }, "answer": [ { "answer": "cone-rod dystrophy", "description": "A retinal degeneration that characterized by progressive deterioration of the cone and rod photoreceptor cells. [url:http\\://lowvision.preventblindness.org/eye-conditions/cone-rod-dystrophy]", "id": "DOID:0050572" } ], "type": "conjunction" }, { "question": "Which disease are the proteins P32969 and Q99805 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Disease", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "P32969" }, "Entity2Attributes": { "id": "Q99805" }, "answer": [ { "answer": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum. [url:http\\://www.cancer.gov/dictionary?CdrID=444983]", "id": "DOID:9256" }, { "answer": "colorectal carcinoma", "description": "A colorectal cancer that arises from the colon or rectum and invades through the muscularis mucosa into the submucosa. [url:https\\://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&version=16.12d&ns=NCI_Thesaurus&code=C4978]", "id": "DOID:0080199" }, { "answer": "large intestine cancer", "description": "An intestinal cancer that effects the long, tube-like organ that is connected to the small intestine at one end and the anus at the other. [url:http\\://en.wikipedia.org/wiki/Large_intestine]", "id": "DOID:5672" } ], "type": "conjunction" }, { "question": "Which disease are the proteins Q9P2E3 and Q9UG56 both associated with?", "EntityType1": "Protein", "EntityType2": "Protein", "MidType": "Disease", "EdgeType": "ASSOCIATED_WITH", "Entity1Attributes": { "id": "Q9P2E3" }, "Entity2Attributes": { "id": "Q9UG56" }, "answer": [ { "answer": "cancer", "description": "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis. [url:http\\://en.wikipedia.org/wiki/cancer, url:http\\://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=cancer]", "id": "DOID:162" } ], "type": "conjunction" } ]