Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.


Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.


Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.


Diminished ovarian reserve is a reliable indicator of infertility in a non-infertile population.


Enhanced early production of inflammatory chemokines damages viral control in the lung.


Exercise increases cancer mortality rates among Chinese citizens.


Exposure to fine particulate air pollution is unrelated to anxiety prevalence.


Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.


Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.


FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).


Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans.


General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.


General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder.


Genomic sequences involved in alternative splicing responsible for Hutchinson-Gilford progeria syndrome (HGPS) are abundant in the ''progerinonly'' allele of Lmna knock-in models.


Gpr124 increases BBB breakdown in mouse models of ischemic stroke.


Having a main partner worsens HIV outcomes.


HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).


Headaches are correlated with cognitive impairment.


Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.


Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.


Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.


Hypocretin neurones suppress panicprone state in rats.


IFI16 impedes STING phosphorylation and translocation, resulting in reduced activation of STING.


IgA plasma cells that are specific for transglutaminase 2 are scarce in the duodenal mucosa of celiac disease patients when the disease is active.


In British Men, haplogroup I decreases risk of cardiovascular disease.


In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.


In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.


In patients with congenital heart defects, β-blockers significantly improve clinical heart failure outcomes.


In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.


Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.


Incidence of heart failure increased by 10% in women since 1979.


Incidence of sepsis has fallen substantially from 2009 to 2014.


Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).


Increased microtubule acetylation exacerbates LRRK2 Roc-COR domain mutation induced locomotor deficits.


Increased microtubule acetylation worsens interference of axonal transport caused by LRRK2 Roc-COR domain mutations.


Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.


Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.


Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.


Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.


Integrated care is ineffective at tackling multiple comorbidities.


Klf4 is not required for proper myeloid cell differentiation.


Lack of FGF21 in mice increases life expectancy.


Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.


MafA phosphorylation decreases its ubiquitination.


Medications to treat obesity are highly effective.


Medications to treat obesity do not have side effects.


Men are more susceptible to death due to pneumonia when compared to women.


Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.


Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.


Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.


Microglia are an innate immune cell type of the peripheral nervous system.


Mitochondria play a trivial role in calcium homeostasis.


Monoclonal antibody targeting of N-cadherin encourages castration resistance.


Monoclonal antibody targeting of N-cadherin encourages metastasis.


Mutations in RIM1 raise levels of IME1 RNA.


N348I mutations reduce resistance to nevirapine.


NR5A2 does not play a role in development of endometrial tissues.


Natriuretic peptides increase susceptibility to diabetes.


Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.


Nonsteroidal antinflammatory drugs are ineffective as cancer treatments.


Normal granulomas form in the presence of TNF in Zebrafish.


Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.


PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice.


PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice.


Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.


Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.


Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falciparum.


Patients with panic anxiety show decreased CSF levels of hypocretin.


Pharmacist attendance at ward rounds increases adverse events in wards.


Physical activity does not improve cognitive function in individuals with Alzheimers.


Polymeal nutrition increases cardiovascular mortality.


Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.


Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.


Pyridostatin decreases telomere fragility in BRCA2-deficient cells.


Pyridostatin encourages proliferation of homologous recombination - defective cells.


Pyridostatin prevents double-strand breaks accumulation.


RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells.


Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume.


Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.


Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.


Risedronate increases risk of vertebral and non-vertebral fractures.


Satellite cell dysfunction is a key factor in sarcopenia development.


Sepsis related mortality has risen from 2009 to 2014.


Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.


Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.


Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.


Stiff substrates encourage mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.


Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.


Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.


Sympathetic nerve activity is reduced throughout normal pregnancy.


Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)


TNFAIP3 is a glioblastoma tumor suppressor.


Taking 400mg of α-tocopheryl acetate in combination with vitamin C reduces the risk of prostate cancer.


The DESMOND program caused substantial weight loss in most participants.


The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.


The PDPN gene deactivates the C-type lectin receptor (CLEC-2).


The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.


The combination of physical examinations with C-reactive protein values do not improve the accuracy of radiographic verified pneumonia predictions.


The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.


The innate immune response struggles to remove small numbers of parasites.


The mean suicide rate in women is lower after miscarriage than live birth.


The most prevalent adverse events to Semaglutide are cardiovascular.


The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.


The one-child policy has created a hospitable environment for female infants.


The peak incidence of fractures occurs in toddlers.


The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is independent of the patient's genetic make-up.


The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.


The risk of breast cancer among parous women decreases with placental weight of pregnancies.


Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events


There is a positive correlation between hip fractures and statin use.


There is no increased risk of hypospadias with clomiphene.


There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.


There is no relation between Erythromycin use and hypertrophic pyloric stenosis.


Treatment with a protein named FN impairs regenerative abilities of aged muscles.


Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.


Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung.


Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.


V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.


Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.


Walking in traffic areas in London improves lung function in elderly adults.


Whole brain radiotherapy increases the occurrence of new brain metastases.


Women with a lower birth weight are more likely to develop breast cancer later in life.


cSMAC formation represses weak ligand signalling.


siRNA knockdown of A20 accelerates tumor progression in an in vivo murine xenograft model.


A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects.


A total of 1,000 people in the UK are asymptomatic carriers of vCJD infection.


ALDH1 expression is associated with better breast cancer outcomes.


APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation, delaying GABA neuron degeneration.


Anthrax spores can be disposed of easily after they are dispersed.


Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.


Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss.


Bone marrow cells contribute to adult macrophage compartments.


Breast cancer development is determined exclusively by genetic factors.


CR is associated with higher methylation age.


CX3CR1 on the Th2 cells impairs T cell survival


CX3CR1 on the Th2 cells suppresses airway inflammation.


Cell autonomous sex determination in somatic cells does not occur in Galliformes.


Chenodeosycholic acid treatment reduces whole-body energy expenditure.


Combination nicotine replacement therapies with varenicline or bupropion lead to significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.


Dexamethasone decreases risk of postoperative bleeding.


Gene expression does not vary appreciably across genetically identical cells.


High cardiopulmonary fitness causes increased mortality rate.


High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).


In mouse models, the loss of CSF1R facilitates MOZ-TIF2-induced leuekmogenesis.


Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.


Leuko-increased blood increases infectious complications in red blood cell transfusion.


Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes.


Macrolides protect against myocardial infarction.


Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.


Mice that lack Interferon-γ or its receptor exhibit high resistance to experimental autoimmune myocarditis.


Mitochondria are uninvolved in apoptosis.


Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.


New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.


Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.


Normal expression of RUNX1 has tumor-promoting effects.


Obesity is determined solely by environmental factors.


Occupancy of ribosomes by IncRNAs do not make functional peptides.


Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegetarians.


PD-1 triggering on monocytes reduces IL-10 production by monocytes.


Patients in stable partnerships have a faster progression from HIV to AIDS.


Pyridostatin destabilizes the G - quadruplex in the telomeric region.


Rapid up-regulation and higher basal expression of interferon-induced genes reduce survival of granule cell neurons that are infected by West Nile virus.


Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.


Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.


Ribosomopathies have a low degree of cell and tissue specific pathology.


Silencing of Bcl2 is important for the maintenance and progression of tumors.


Suboptimal nutrition is not predictive of chronic disease


Taking 400mg of α-tocopheryl acetate helps to prevent prostate cancer.


Taxation of sugar-sweetened beverages had no effect on the incidence rate of type II diabetes in India.


The genomic aberrations found in matasteses are very similar to those found in the primary tumor.


The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease.


The risk of male prisoners harming themselves is ten times that of female prisoners.


Tirasemtiv has no effect on fast-twitch muscle.


Transplanted human glial progenitor cells are incapable of forming a neural network with host animals' neurons.


UCB T cells reduce TCR diversity after transplantation.


Ultrasound guidance significantly raises the number of traumatic procedures when attempting needle insertion.


Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.


aPKCz causes tumour enhancement by affecting glutamine metabolism.


"Sternal fracture in growing children is a rare and often overlooked fracture."


Specialised training of phonological awareness is indicated in every preschool child.


Tumour expression of VEGF is associated with venous invasion and survival in pT3 renal cell carcinoma.


Normally sighted, visually impaired, and blind pedestrians are accurate and reliable at making street crossing decisions.


A man would smell a rose and then throw it away.


French lay people and health professionals find it acceptable to breach confidentiality to protect a patient's wife from a sexually transmitted disease.


Different follow-up modalities may play a role in the diagnosis of asymptomatic endometrial cancer relapses.


Chest wall irradiation should be included after mastectomy and negative node breast cancer.


Vaginal intraepithelial neoplasia has the same evolution as cervical intraepithelial neoplasia.


Patients can be anticoagulated after intracerebral hemorrhage.


Oncoplastic surgery is not a contraindication for accelerated partial breast radiation using the interstitial multicatheter brachytherapy method.


Cutaneous melanoma in a multiethnic population is a different disease.


Bipolar disorders are underdiagnosed in patients with depressive episodes.


The lifetime prevalence of impetigo, molluscum, and herpes infection is indeed increased in children with atopic dermatitis.


Aerobic fitness influences microvascular function in healthy adults at risk of developing Type 2 diabetes.


Web-based systems are the answer for standardizing care in medical oncology.


Prophylactic fixation is a cost-effective method to prevent a future contralateral fragility hip fracture.


Neighbourhood social capital and availability of sports facilities are related to sports participation among Dutch adolescents.


The scores obtained from combining process indicators to evaluate the quality of care for surgical patients with colorectal cancer are consistent with short-term outcome.


Ambu self-inflating bag and Neopuff infant resuscitator can provide adequate and safe manual inflations for infants up to 10 kg weight.


Opioid dependence and methadone maintenance treatment (MMT) are documented in the medical record.