I wouldn't, however, trust him around anything smaller than he is. I've had to rescue several wild baby bunnies and chipmunks from him, others.... well, he's great for keeping the mouse population away from the barn, but he doesn't limit himself to mice. On the other hand, one of my house cats is great with my friend's pet rabbit. If you get kittens with relaxed personalities (not natural mousers) and raise them around the barn fluffies, from the time they're small kittens, they might be okay. i dont own any cats..but...good lawd my neighbor does!!! probably 20 plus cats!! they are everywhere out here.. ive seen them brush up against my free roaming chickens several times and never offered to mess with them at all..a couple of them were sleeping with my goats once also...the cats and my animals mingled together with no problems until i got the great pyrenees...She doesnt allow the cats around the goats period....the older my GP gets the less things she will allow around those goats...lol...its kinda funny to watch her progress into an awesome livestock protector!! Im glad she keeps them outta the goat pen now anyway since i feed her that 50.00 a bag dog food (Blue Buffalo)..I think the cats would do fine..but id watch them around the babies for a while without them knowing your watching them...If you have roosters on the ground they will fight the cats away from your hens anyway... BEST OF LUCK!! Depends on the personality of