alone, and malaria has vanished from much of the world, including the U.S. As so often happens in the battle against disease, however, evolution aids the enemy. The selection pressure on pathogens to develop resistance to new drugs is huge. In recent weeks, the emergence on the Thai-Myanmar border of malaria strains resistant to artemisin, a plant-derived drug, have led to pessimistic headlines and reminders of the setback caused by resistance to the drug chloroquine, which began in the 1950s. Belatedly, here is my Mind and Matter column from the Wall Street Journal on 24 March 2012. In her remarkable new book "The Rambunctious Garden," Emma Marris explores a paradox that is increasingly vexing the science of ecology, namely that the only way to have a pristine wilderness is to manage it intensively. Left unmanaged, a natural habitat will become dominated by certain species, often invasive aliens introduced by human beings. "A historically faithful ecosystem is necessarily a heavily managed ecosystem," she writes. "The ecosystems that look the most pristine are perhaps the least likely to be truly wild." Scientists, it's said, behave more like lawyers than philosophers. They do not so much test their theories as prosecute their cases, seeking supportive evidence and ignoring data that do not fit-a failing known as confirmation bias. They then accuse their opponents of doing the same thing. This is what makes debates over nature and nurture, dietary fat and climate change so polarized. But just because the prosecutor is biased in favor