not yet on sale in New Zealand, as it is not registered as a medicine. Its smoke is not obnoxious, and does not come under the bans on tobacco smoking. Ruyan says it is a cigarette substitute, not a smoking cessation aid. No therapeutic claims is being made for it as a smoking cessation aid. If it should be legal to sell it, it would be permissible to advertise it in New Zealand, as long as no claim to stop smoking is made. It could perhaps be advertised as "Ruyan -- a satisfying, safer smoke." Contra-indications: Non smokers . Nicotine-nave non-smokers may experience the same effects as first-time smokers -- coughing, gagging, and on inhaling into the lungs, nausea, dizziness or vomiting. Pregnancy As this device can deliver high doses of nicotine, it is contra-indicated in pregnancy, unless the woman has not been able to quit smoking by other means. Cardiovascular effects Nicotine in high dose is not advisable for those with heart disease or irregular heart rhythm as it could possibly trigger heart beat irregularities. Children or adults if they were able to unscrew the filter, would be at risk of nicotine poisoning if they put the filter in their mouth, as one cartridge contains as much nicotine as in 5 cigarettes.. The filter can be screwed in very tightly or loosely, and if screwed even moderately tightly can be difficult even for adults to open. The lethal nicotine dose for adults is 40-60 mg of nicotine, and 10