critical variables such as health status and drug use patterns. 9 The Vancouver Association of Drug Users has organized campaigns of this type in the vicinity of INSITE 10 Members of the EAC consider that these concerns are unfounded and propose that publicity surrounding SISs serves mainly to draw attention to the dangers of addiction and the miseries of addicts. Appendix A: Research questions developed by the EAC Stream #1 To what extent do SISs in general, and especially the INSITE service in Vancouver, contribute to, or detract from, the attainment of public health and public order objectives in the short and longer term? If SISs in general, and especially the INSITE service in Vancouver, contribute to specific public health and public order objectives, are they cost-effective relative to other reasonable methods that are, or might be, used to achieve these objectives? Specific issues of concern Influence of SISs on the prevalence of public self-injection in the short and longer term (2-3 years) and, if appropriate, evidence for the cost-effectiveness of SISs relative to alternative means of reducing the prevalence of public self-injection. Influence of SISs on rates of high-risk behaviours such as needle sharing in the short and longer term (2-3 years) and, if appropriate, evidence for the cost-effectiveness of SISs relative to alternative means of reducing the prevalence of reducing these rates. Influence of SISs on rates of local hospital admissions and, in particular, ER admissions related to self-injection in the short and longer term (2-3 years) and,