Rafael at right-back. Patrice Evra is probable to start at left-back over Alexander Buttner. In central-midfield, Paul Scholes and Michael Carrick were rested at the midweek and they appear to be the strongest candidates to start. Out wide, Nani is expected on the right flank while any of Danny Welbeck , Ryan Giggs , Wayne Rooney , or Shinji Kagawa could pop up out wide to the left. Up front, Robin van Persie will be the lead striker while either Kagawa or Rooney will be in behind him 'in the hole'. Tottenham : Brad Friedel remains the No.1 ahead of France No.1 Hugo Lloris. Assou-Ekotto's injury shakes up Spurs' back four and last week, it was Gareth Bale that was deployed at left-back. That didn't work out too well so it's very possible that Jan Vertonghen slides over to the left tomorrow at Old Trafford. If Vertonghen does slide over, then either Steven Caulker or Michael Dawson likely partners William Gallas in central-defense. Kyle Walker will be the right-back. In Andre Villas-Boas' 4-2-3-1 system for Spurs, Sandro and Mousa Dembele are his deep central-midfielders. In the attacking midfield band of three, Aaron Lennon is first-choice out on the right and Bale is expected on the left. If Bale is deployed again at left-back, then Clint Dempsey might be the left-sided attacker. In the central-attacking-midfield role, either Dempsey or Gylfi Sigurdsson is anticipated. Jermaine Defoe will be the lone striker. TACTICAL KEYS * Central-midfield battle : Perhaps the biggest key in