is your responsibility to ensure that the PDF (and the figures in particular) is suitable for the review process. If the PDF is not of sufficient quality it will be returned to you, resulting in a delay in the review process. Troubleshooting A PDF can be made by compiling separate PDF files; however, this usually generates a larger file size. If the PDF you have created is larger than 5MB, please follow our instructions on how to reduce the size of the file below. Reducing the size of the file This can be done as follows: Open the PDF in Adobe Acrobat. Note: a full version of Adobe Acrobat is required. Adobe Acrobat Reader does not allow you to create PDF files. Go to File then Print, and select Adobe PDF as the printer. Select OK. You will be required to name the document and choose a location on your computer to save it. A new PDF will be created. Check that the PDF looks correct and that no information has been lost. Some pages might need re-orientating. If using a Mac, select PDF from the bottom of the Print dialog box and choose Save as PDF.