AndreaBozzo/ceres-open-data-index huggingface dataset:
A mathematical model of optimized radioiodine-131 therapy of Graves' hyperthyroidism

Background
          The current status of radioiodine-131 (RaI) dosimetry for Graves' hyperthyroidism is not clear. Recurrent hyperthyroidism and iatrogenic hypothyroidism are two problems which interact such that trying to solve one leads to exacerbation of the other. Optimized RaI therapy has therefore begun to be defined just in terms of early hypothyroidism (ablative therapy) as physicians have given up on reducing hypothyroidism.
        
        
          Methods
          Optimized therapy is evaluated both in terms of the greatest separation of cure rate from hypothyroidism rate (non-ablative therapy) or in terms of early hypothyroidism (ablative therapy) by mathematical modeling of outcome after radioiodine and critically discussing the three common methods of RaI dosing for Graves' disease.
        
        
          Results
          Cure follows a logarithmic relationship to activity administered or absorbed dose, while hypothyroidism follows a linear relationship. The effect of including or omitting factors in the calculation of the administered I–131 activity such as the measured thyroid uptake and effective half-life of RaI or giving extra compensation for gland size is discussed.
        
        
          Conclusions
          Very little benefit can be gained by employing complicated methods of RaI dose selection for non-ablative therapy since the standard activity model shows the best potential for cure and prolonged euthyroidism. For ablative therapy, a standard MBq/g dosing provides the best outcome in terms of cure and early hypothyroidism.
Compound 526812: 17-Hydroxy-nonadecanoic, methyl ester, tBDMS ether

Chemical compound data from PubChem database. IUPAC Name: methyl 17-[tert-butyl(dimethyl)silyl]oxynonadecanoate. Molecular Formula: C26H54O3Si. Molecular Weight: 442.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 529147: 1-Dodecanamine, N-isopropylidene

Chemical compound data from PubChem database. IUPAC Name: N-dodecylpropan-2-imine. Molecular Formula: C15H31N. Molecular Weight: 225.41. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Two C or not two C: recurrent disruption of Zn-ribbons, gene duplication, lineage-specific gene loss, and horizontal gene transfer in evolution of bacterial ribosomal proteins

Background
          Ribosomal proteins are encoded in all genomes of cellular life forms and are, generally, well conserved during evolution. In prokaryotes, the genes for most ribosomal proteins are clustered in several highly conserved operons, which ensures efficient co-regulation of their expression. Duplications of ribosomal-protein genes are infrequent, and given their coordinated expression and functioning, it is generally assumed that ribosomal-protein genes are unlikely to undergo horizontal transfer. However, with the accumulation of numerous complete genome sequences of prokaryotes, several paralogous pairs of ribosomal protein genes have been identified. Here we analyze all such cases and attempt to reconstruct the evolutionary history of these ribosomal proteins.
        
        
          Results
          Complete bacterial genomes were searched for duplications of ribosomal proteins. Ribosomal proteins L36, L33, L31, S14 are each duplicated in several bacterial genomes and ribosomal proteins L11, L28, L7/L12, S1, S15, S18 are so far duplicated in only one genome each. Sequence analysis of the four ribosomal proteins, for which paralogs were detected in several genomes, two of the ribosomal proteins duplicated in one genome (L28 and S18), and the ribosomal protein L32 showed that each of them comes in two distinct versions. One form contains a predicted metal-binding Zn-ribbon that consists of four conserved cysteines (in some cases replaced by histidines), whereas, in the second form, these metal-chelating residues are completely or partially replaced. Typically, genomes containing paralogous genes for these ribosomal proteins encode both versions, designated C+ and C-, respectively. Analysis of phylogenetic trees for these seven ribosomal proteins, combined with comparison of genomic contexts for the respective genes, indicates that in most, if not all cases, their evolution involved a duplication of the ancestral C+ form early in bacterial evolution, with subsequent alternative loss of the C+ and C- forms in different lineages. Additionally, evidence was obtained for a role of horizontal gene transfer in the evolution of these ribosomal proteins, with multiple cases of gene displacement 'in situ', that is, without a change of the gene order in the recipient genome.
        
        
          Conclusions
          A more complex picture of evolution of bacterial ribosomal proteins than previously suspected is emerging from these results, with major contributions of lineage-specific gene loss and horizontal gene transfer. The recurrent theme of emergence and disruption of Zn-ribbons in bacterial ribosomal proteins awaits a functional interpretation.
2018 National Directory of Drug and Alcohol  Abuse Treatment Facilities

The National Directory of Drug and Alcohol Abuse Treatment Facilities - 2018 is a listing of federal, state, andlocal government facilities and private facilities that provide substance abuse treatment services. It includestreatment facilities that (1) are licensed, certified, or otherwise approved for inclusion in the Directory by theirState Substance Abuse Agencies, and (2) responded to the 2017 National Survey of Substance Abuse TreatmentServices (N-SSATS). The information about each facility that appears in this Directory was provided by thatfacility in response to the 2017 N-SSATS. N-SSATS is conducted annually by the Substance Abuse and MentalHealth Services Administration (SAMHSA).The Directory is ordered alphabetically by state, by city within each state, and by facility name within each city.Each facility listing includes codes that represent the services offered and other features of the facility, including codes that indicate services for hearing impaired and non-English-speaking clients. Codes are defined in a key shown on pages v-vii. Because the services offered by a particular facility may change over time, it is always a good idea to verify the information in this Directory when contacting a facility.
Compound 525806: N,N'-bis-(3-Bromophenyl)formamidine

Chemical compound data from PubChem database. IUPAC Name: N,N'-bis(3-bromophenyl)methanimidamide. Molecular Formula: C13H10Br2N2. Molecular Weight: 354.04. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 527557: 1,3-Cyclohexadiene, 6-bromo

Chemical compound data from PubChem database. IUPAC Name: 5-bromocyclohexa-1,3-diene. Molecular Formula: C6H7Br. Molecular Weight: 159.02. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E40161-T1: [Translated] TEXTILE REINFORCEMENT LINER USED IN THE MANUFACTURE OF LAYERED ARTICLES AND LAYERED ARTICLES CONTAINING THIS LINER.

This invention relates to a novel type of textile reinforcement adapted to be used for making laminated complexes, of the type constituted by at least one layer of reinforcing yarns. The yarns are bonded together by adhesion with binding yarns, disposed transversely, in a small proportion with respect to the reinforcing yarns. Reinforcing yarns are spaced apart from one another so as to form stable and undeformable holes of definite shape. Additional binding yarns are disposed on either side of each of the strips of reinforcing yarns.
Patent AT-E401308-T1: [Translated] 4-AMINOPIPERIDINE DERIVATIVES AND THEIR USE AS MEDICINAL PRODUCTS

Chemical patent from PubChem database. Patent Number: AT-E401308-T1. Title: Pharmaceutical Salt Forms. Filing Date: 2001-10-25. Inventors: Rodriguez, Juan, White, Jennifer. Abstract: Novel pharmaceutical salt forms are provided, exhibiting improved physicochemical properties including enhanced solubility, stability, and bioavailabi... IPC Classifications: C07C, C07B, A61K. This patent covers 40 claims related to 3 chemical compounds. Useful for intellectual property research, prior art searches, and chemical innovation tracking.
California Hospital Inpatient Mortality Rates and Quality Ratings

The dataset contains risk-adjusted mortality rates, quality ratings, and number of deaths and cases for 6 medical conditions treated (Acute Stroke, Acute Myocardial Infarction, Heart Failure, Gastrointestinal Hemorrhage, Hip Fracture and Pneumonia) and 3 procedures performed (Carotid Endarterectomy, Pancreatic Resection, and Percutaneous Coronary Intervention) in California hospitals. The 2023 IMIs were generated using AHRQ Version 2024, while previous years' IMIs were generated with older versions of AHRQ software (2022 IMIs by Version 2023, 2021 IMIs by Version 2022, 2020 IMIs by Version 2021, 2019 IMIs by Version 2020, 2016-2018 IMIs by Version 2019, 2014 and 2015 IMIs by Version 5.0, and 2012 and 2013 IMIs by Version 4.5). The differences in the statistical method employed and inclusion and exclusion criteria using different versions can lead to different results. Users should not compare trends of mortality rates over time. However, many hospitals showed consistent performance over years; “better” performing hospitals may perform better and “worse” performing hospitals may perform worse consistently across years. This dataset does not include conditions treated or procedures performed in outpatient settings. Please refer to statewide table for California overall rates: https://data.chhs.ca.gov/dataset/california-hospital-inpatient-mortality-rates-and-quality-ratings/resource/af88090e-b6f5-4f65-a7ea-d613e6569d96
Overdistension in ventilated children

Ventilating patients with acute respiratory failure according to standardized recommendations can lead to varying volume–pressure (V-P) relationships and overdistension. Young children may be more susceptible than adults to overdistension, and individual evaluation of the effects of ventilator settings is therefore required. Three studies have applied indices for the detection of overdistension to dynamic V-P curves in ventilated children. Two of those studies compared these indices to those obtained using a reference technique ([quasi]-static V-P curves), and suggested that the c coefficient of a second order polynomial equation (SOPE) and the ratio of the volume-dependent elastance to total dynamic elastance (%E2) were suitable indices for estimating overdistension.
Patent AT-E400458-T1: [Translated] CONTROLLED AIR CONDITIONING DEVICE AND METHOD FOR CONTROLLING AIR CONDITIONING

The device has a compressor (2) driven by an engine (1) of a vehicle through a clutch (3). A complimentary circuit (33) is arranged between a coolant driving branch (30) and a suction branch (32) to send gases compressed by the compressor directly towards the inlet of the compressor. The complementary circuit has an electromagnetic valve (5) and a logic controller (10) for enabling and disabling the complimentary circuit. An independent claim is also included for a method to control an air-conditioning device for an urban public transport vehicle.
Patent AT-E400693-T1: [Translated] METHOD FOR COATING TEXTILE SURFACE STRUCTURES WITH EMULSIONS MADE OF ELASTOMERIC POLYMERS AND POLYURETHANE DISPERSIONS

A method for coating a substrate comprises the steps of:(I) applying a layer on the substrate of a curable composition comprising:(A) a water continuous emulsion comprising a curable elastomeric polymer having a viscosity of 0.5-1,000,000 KPa-s and a glass transition temperature up to 50° C.,(B) an aqueous polyurethane dispersion, and optionally(C) a cure agent(II) exposing the layer to air for sufficient time to form a cured coating. Coated fabrics prepared accordingly are particularly useful in the construction of automobile protective airbags or other such inflatable coated textile devices.
United States: 2011-2012 NSDUH

This report presents the United States\'s estimates for 25 measures of substance use and mental health based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for the United States for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.
Maine: 2011-2012 NSDUH

This report presents Maine\'s estimates for 25 measures of substance use and mental health based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.
Patent AT-E401061-T1: [Translated] MULTI-LAYER TABLET CONTAINING PRAVASTATIN AND ASPIRIN AND METHOD

A multilayered tablet having three or more layers is provided which is useful for cholesterol lowering and reducing the risk of a myocardial infarction, which includes a first layer containing aspirin, another layer containing pravastatin, and a middle barrier layer, which preferably contains a buffering agent, which separates the first layer containing aspirin from the other layer containing pravastatin, and prevents or minimizes interaction of aspirin with pravastatin. A method for lowering cholesterol and reducing risk of a myocardial infarction employing such composition is also provided.
Compound 528176: 1,3-Cyclopentadiene, 2-ethyl

Chemical compound data from PubChem database. IUPAC Name: 2-ethylcyclopenta-1,3-diene. Molecular Formula: C7H10. Molecular Weight: 94.15. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E400661-T1: [Translated] COMMERCIAL PRODUCTION OF CHYMOSIN IN PLANTS

A method for the commercial production of chymosin which involves the recombinant expression of chymosin in plant seeds, that enables chymosin to accumulate to at least 0,5 % (w/w) of total seed protein is described. An improved method for the isolation of chymosin from the seed is also described.
Compound 525327: Pyrazolo[1,5-d][1,2,4]triazin-3-one, 2,6-dimethyl-7-phenyl

Chemical compound data from PubChem database. IUPAC Name: 2,6-dimethyl-7-phenyl-5,7-dihydropyrazolo[1,5-d][1,2,4]triazin-4-one. Molecular Formula: C13H14N4O. Molecular Weight: 242.28. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Hospital Inpatient Discharges (SPARCS De-Identified): 2019

The Statewide Planning and Research Cooperative System (SPARCS) Inpatient De-identified File contains discharge level detail on patient characteristics, diagnoses, treatments, services, and charges. This data file contains basic record level detail for the discharge. The de-identified data file does not contain data that is protected health information (PHI) under HIPAA. The health information is not individually identifiable; all data elements considered identifiable have been redacted. For example, the direct identifiers regarding a date have the day and month portion of the date removed. <b>Note: </b>This dataset may be downloaded from the attachments section of this page in a smaller, compressed format.
Search for antisense copies of beta-globin mRNA in anemic mouse spleen

Background
          Previous studies by Volloch and coworkers have reported that during the expression of high levels of β-globin mRNA in the spleen of anemic mice, they could also detect small but significant levels of an antisense (AS) globin RNA species, which they postulated might have somehow arisen by RNA-directed RNA synthesis. For two reasons we undertook to confirm and possibly extend these studies. First, previous studies in our lab have focussed on what is an unequivocal example of host RNA-directed RNA polymerase activity on the RNA genome of human hepatitis delta virus. Second, if AS globin species do exist they could in turn form double-stranded RNA species which might induce post-transcriptional gene silencing, a phenomenon somehow provoked in eukaryotic cells by AS RNA sequences.
        
        
          Results
          We reexamined critical aspects of the previous globin studies. We used intraperitoneal injections of phenylhydrazine to induce anemia in mice, as demonstrated by the appearance and ultimate disappearance of splenomegaly. While a 30-fold increase in globin mRNA was detected in the spleen, the relative amount of putative AS RNA could be no more than 0.004%.
        
        
          Conclusions
          Contrary to earlier reports, induction of a major increase in globin transcripts in the mouse spleen was not associated with a detectable level of antisense RNA to globin mRNA.
Compound 529878: Benzyl 8-hydroxy-5-oxo-8-phenyloctahydro-6-indolizinylcarbamate

Chemical compound data from PubChem database. IUPAC Name: [5-[(3,5-dimethylpyrazin-2-yl)methyl]furan-2-yl]methanol. Molecular Formula: C12H14N2O2. Molecular Weight: 218.25. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 525811: N,N'-bis-(4-Ethoxyphenyl)formamidine

Chemical compound data from PubChem database. IUPAC Name: N,N'-bis(4-ethoxyphenyl)methanimidamide. Molecular Formula: C17H20N2O2. Molecular Weight: 284.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 525175: Octaethylene glycol, monoallyl ether, acetate

Chemical compound data from PubChem database. IUPAC Name: 2-[2-[2-[2-[2-[2-[2-(2-prop-2-enoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl acetate. Molecular Formula: C21H40O10. Molecular Weight: 452.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Articular cartilage and changes in Arthritis: Collagen of articular cartilage

The extracellular framework and two-thirds of the dry mass of adult articular cartilage are polymeric collagen. Type II collagen is the principal molecular component in mammals, but collagens III, VI, IX, X, XI, XII and XIV all contribute to the mature matrix. In developing cartilage, the core fibrillar network is a cross-linked copolymer of collagens II, IX and XI. The functions of collagens IX and XI in this heteropolymer are not yet fully defined but, evidently, they are critically important since mutations in COLIX and COLXI genes result in chondrodysplasia phenotypes that feature precocious osteoarthritis. Collagens XII and XIV are thought also to be bound to fibril surfaces but not covalently attached. Collagen VI polymerizes into its own type of filamentous network that has multiple adhesion domains for cells and other matrix components. Collagen X is normally restricted to the thin layer of calcified cartilage that interfaces articular cartilage with bone.
Patent AT-E401605-T1: [Translated] METHOD AND APPARATUS FOR EXTENDED CONTENT STORAGE

An extended content storage system, apparatus, and method are disclosed. The system includes a client and server capable of being communicatively coupled to a communications medium, and a module to monitor the type of content type and its transmission rate as it is stored in a limited local memory maintained by the client. The method includes monitoring the local content storage memory as it is used to acquire the content, and establishing a connection between the client and server to enable sending a selected portion of the acquired content to the server. The method enables subsequent portions of the content to be acquired without exceeding the local memory storage limit, and review of the acquired content during acquisition of subsequent portions.
The NSDUH Report: Nonmedical Use of Prescription-Type Drugs, by County Type

This report uses 2005 to 2011 National Survey on Drug Use and Health (NSDUH) to assess past year and past month nonmedical use of prescription-type drugs among persons aged 12 or older for rural non-metropolitan counties, urbanized non-metropolitan counties and metropolitan counties. Results are shown by age group, gender, and prescription drug type.
Compound 530596: 4-Cyanobenzoic acid, 1-adamantylmethyl ester

Chemical compound data from PubChem database. IUPAC Name: 1-adamantylmethyl 4-cyanobenzoate. Molecular Formula: C19H21NO2. Molecular Weight: 295.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 530239: 9-(Trimethylsilyl)-2,6-bis[(trimethylsilyl)oxy]-9H-purine

Chemical compound data from PubChem database. IUPAC Name: trimethyl-(9-trimethylsilyl-2-trimethylsilyloxypurin-6-yl)oxysilane. Molecular Formula: C14H28N4O2Si3. Molecular Weight: 368.65. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Behavioral Health Barometer: Vermont, 2014

This is a behavioral health report for the state of Vermont. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment, and medicare enrollees for the years 2009 to 2013.
Compound 525535: (4-Cyclohexylmethoxy-phenyl)-acetic acid, methyl ester

Chemical compound data from PubChem database. IUPAC Name: methyl 2-[4-(cyclohexylmethoxy)phenyl]acetate. Molecular Formula: C16H22O3. Molecular Weight: 262.34. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.