AndreaBozzo/ceres-open-data-index huggingface dataset:
National Directory of Drug and Alcohol Abuse Treatment Facilities - 1992

The National Directory of Drug and Alcohol Abuse Treatment Programs 1992 lists federal, state, local, and private facilities that provide substance abuse treatment services. The directory includes treatment facilities that are licensed, certified, or otherwise approved for inclusion in the directory by their state substance abuse agencies and that responded to the 1991 National Survey of Substance Abuse Treatment Services (N-SSATS). The information about each facility that appears in this directory was provided by that facility in response to the 1991 N-SSATS. The Substance Abuse and Mental Health Services Administration (SAMHSA) conducts the N-SSATS annually.
Compound 527307: 2-(4-Ethenyl-4-methyl-3-prop-1-en-2-ylcyclohexyl)propan-2-yl acetate

Chemical compound data from PubChem database. IUPAC Name: 2-(4-ethenyl-4-methyl-3-prop-1-en-2-ylcyclohexyl)propan-2-yl acetate. Molecular Formula: C17H28O2. Molecular Weight: 264.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Attitudes of the Japanese public and doctors towards use of archived information and samples without informed consent: Preliminary findings based on focus group interviews

Background
          The purpose of this study is to explore laypersons' attitudes toward the use of archived (existing) materials such as medical records and biological samples and to compare them with the attitudes of physicians who are involved in medical research.
        
        
          Methods
          Three focus group interviews were conducted, in which seven Japanese male members of the general public, seven female members of the general public and seven physicians participated.
        
        
          Results
          It was revealed that the lay public expressed diverse attitudes towards the use of archived information and samples without informed consent. Protecting a subject's privacy, maintaining confidentiality, and communicating the outcomes of studies to research subjects were regarded as essential preconditions if researchers were to have access to archived information and samples used for research without the specific informed consent of the subjects who provided the material. Although participating physicians thought that some kind of prior permission from subjects was desirable, they pointed out the difficulties involved in obtaining individual informed consent in each case.
        
        
          Conclusions
          The present preliminary study indicates that the lay public and medical professionals may have different attitudes towards the use of archived information and samples without specific informed consent. This hypothesis, however, is derived from our focus groups interviews, and requires validation through research using a larger sample.
Compound 526275: 1,3,6,9-Tetrabromo-dibenzofuran

Chemical compound data from PubChem database. IUPAC Name: 1,3,6,9-tetrabromodibenzofuran. Molecular Formula: C12H4Br4O. Molecular Weight: 483.77. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E400624-T1: [Translated] ACRYLIC PRESSURE SENSITIVE HOT HOT ADHESIVE AND USE THEREOF

The present invention provides a hot melt acrylic pressure sensitive adhesive (PSA) comprising an acrylic polymer having units derived from one or more C1-C20 alkyl esters of acrylic or methacrylic acid and units derived from one or more vinyl esters corresponding to the formula: <CHEM> wherein R<1>, R<2> and R<3> each independently represent an alkyl group and the total number of carbon atoms in the vinyl ester is from 7 to 18. The PSA is particularly suitable for sticking objects to a low surface energy substrate.
Utility of the Mayo End-Stage Liver Disease (MELD) score in assessing prognosis of patients with alcoholic hepatitis

Background
          Alcoholic hepatitis is characterized by acute, or acute-on-chronic hepatic failure and associated with a high mortality. Specific therapies should be considered for those at high risk of mortality. The Mayo End-Stage Liver Disease (MELD) score is a marker of disease severity and mortality in persons with chronic alcoholic liver disease. Our aims were to assess the utility of the MELD score as a predictor of short-term mortality in persons with alcoholic hepatitis.
        
        
          Methods
          We assessed the utility of the MELD score and compared it with the Discriminant Function (DF) as a predictor of mortality in 34 patients hospitalized with alcoholic hepatitis.
        
        
          Results
          The area under the curve of a receiver operating characteristic curve for the MELD score was 0.82 (confidence intervals 0.65–0.98), and for the DF was 0.86 (confidence intervals 0.70–1.00). However, the sensitivity and specificity in predicting 30-day mortality for a MELD score of greater than 11 was 86% and 81%, but for a DF greater than 32 was 86% and 48% respectively. The presence of ascites and bilirubin greater than 8 mg/dL were also highly predictive of mortality with a sensitivity of 71% and a specificity of 96%.
        
        
          Conclusions
          Alcoholic hepatitis remains associated with a high mortality in hospitalized patients. The MELD score performs as well as the DF in predicting mortality at 30 days. A MELD score of greater than 11, or the presence of both ascites and an elevated bilirubin greater than 8 mg/dL should prompt consideration of specific therapeutic interventions to reduce mortality.
The method of bladder drainage in spinal cord injury patients may influence the histological changes in the mucosa of neuropathic bladder – a hypothesis

Background
          In spinal cord injury (SCI) patients, no correlation was found between the number of bladder infections per year, the period since injury, the neurologic level of the spinal cord lesion and the histopathology of the urinary bladder mucosa. The use of chronic indwelling urethral and/or suprapubic catheters in SCI patients is often associated with inflammatory and proliferative pathological conditions in neuropathic bladder.
        
        
          Presentation of the hypothesis
          We propose a hypothesis that the type of bladder drainage in SCI patients influences the histological changes in the mucosa of neuropathic bladder. This hypothesis implies that SCI patients with long-term indwelling urinary catheters develop certain histological changes in bladder mucosa, which are seen less frequently in SCI patients, who do not use long-term indwelling catheters. The latter group includes patients, who perform regular intermittent catheterisation and those, who wear a penile sheath and empty their bladders satisfactorily by reflex voiding.
          We hypothesise that the following histological lesions are seen more frequently in the neuropathic bladder of SCI patients with long-term indwelling catheters.
          (1) Papillary or polypoid cystitis; (2) widespread cystitis glandularis; (3) moderate to severe, acute and chronic inflammatory changes in bladder mucosa; (4) follicular cystitis; (5) squamous metaplasia; and (6) urothelial dysplasia
          As per this hypothesis, it is postulated that the above pathological conditions are seen less often in SCI patients, who achieve complete, low-pressure emptying of the neuropathic bladder by regular intermittent catheterisation, and SCI patients with penile sheath drainage, who empty their bladders satisfactorily by reflex voiding.
        
        
          Testing the hypothesis
          A large prospective study of bladder biopsies in SCI patients practising different methods of bladder drainage is required to validate this hypothesis that the histological changes in bladder mucosa are related to the method of bladder drainage in SCI patients.
        
        
          Implications of the hypothesis
          We propose a hypothesis that the method of bladder drainage in SCI patients influences histological changes in the bladder mucosa. If this hypothesis is validated, methods of bladder drainage such as intermittent catheterisation, which do not require the use of chronic indwelling catheters, should be recommended, in order to minimise adverse histological changes in the mucosa of neuropathic bladder of spinal cord injury patients.
Muscle Specific Fragile X Related Protein 1 Isoforms are Sequestered in the Nucleus of Undifferentiated Myoblast

Background
          The family of Fragile X Mental Retardation Proteins is composed of three members: Fragile Mental Retardation 1, Fragile X Related 1 and X Related 2 proteins. These proteins are associated with mRNPs within translating ribosomes and have the capacity to shuttle between the nucleus and the cytoplasm. Great attention has been given to FMRP due to its implication in human hereditary mental retardation while FXR1P and FXR2P have only recently been studied.
        
        
          Results
          Using antibodies directed against several epitopes of FXR1P, we have detected protein isoforms generated by small peptides pocket inserts. Four isoforms of MW 70, 74, 78, 80 kDa are widely distributed in mouse organs, while in striated muscles these isoforms are replaced by proteins of 82 and 84 kDa containing an extra pocket of 27 aa. Expression of these muscle isoforms is an early event during in vitro differentiation of myoblasts into myotubes and correlates with the activation of muscle-specific genes. However, while FXR1P82,84 are associated with cytoplasmic mRNPs in myotubes, they are sequestered in the nuclei of undifferentiated myoblasts. These observations suggest that, in addition to a cytoplasmic function yet to be defined, FXR1P82,84 may play a nuclear role in pre-mRNA metabolism.
        
        
          Conclusions
          The pattern of subcellular partitioning of FXR1P isoforms during myogenesis is unique among the family of the FXR proteins. The model system described here should be considered as a powerful tool for ongoing attempts to unravel structure-function relationships of the different FMR family members since the potential role(s) of FXR1P as a compensatory factor in Fragile X syndrome is still elusive.
Risk and Protective Factors Tables (Standard Errors and P Values) - 3.1 to 3.25

These detailed tables present standard errors for totals and prevalence estimates of risk and protective factors regarding substance use from the 2010 National Survey on Drug Use and Health (NSDUH). The factors include perceptions of 1) risk of substance use, 2) availability of substances, 3) parental disapproval of youth substance use, 4) peer substance use. These factors include measures of delinquent behavior, religious involvement, exposure to prevention messages, and parental involvement. Standard errors are provided by age group, gender, race/ethnicity, geographic area, and youth substance use behavior. Standard errors are provided for both 2010 and 2009.
Idaho 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.
CDC STATE System Tobacco Legislation - Youth Access

1995-2024. Centers for Disease Control and Prevention (CDC). State Tobacco Activities Tracking and Evaluation (STATE) System. Legislation—Youth Access. The STATE System houses current and historical state-level legislative data on tobacco use prevention and control policies.  Data are reported on a quarterly basis. Data include information related to restrictions, enforcement and penalties associated with the sale of cigarettes to youth through retail sales and vending machines.
HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels

Background
          HIPK2 (homeodomain-interacting protein kinase 2) has been identified as a nuclear serine/threonine kinase. A central function of HIPK2 is repressing transcription of homeodomain containing transcription factors.
        
        
          Results and Conclusions
          We show here that HIPK2 activates transcription mediated by tumor suppressor p53 responsive promoter elements. Overexpression of HIPK2 leads to an increase of p53 protein expression or stability, which becomes enhanced further in the presence of the DNA damaging drug doxorubicin. The effects of HIPK2 on p53 are not observed with kinase deficient HIPK2 mutants. However, HIPK2 is not sufficient for phosphorylation of three crucial serine residues of p53, suggesting that HIPK2-induced p53 activation does not involve phosphorylation of p53. Instead, HIPK2 leads to a downregulation of p53-induced Mdm2 protein and this may lead to stabilization of p53. Overexpression of HIPK2 does not lead to a change of Mdm2 mRNA expression. The data suggest that HIPK2 plays a critical role in p53 mediated cellular responses by removing the p53 inhibitor protein Mdm2 via modification of the protein itself or its intracellular movement.
March Office Hours: Updates on NCWDMS and AFCARS 2020 Reporting

The Children's Bureau Data Analytics and Reporting Team held their third AFCARS Open Office Hours for 2023. These sessions are for state and tribal program administrators, child welfare data leaders, and information system programmers. It provides an opportunity to ask questions specific to your agency's implementation of AFCARS 2020. The March session covered frequently asked questions and answers, updates from the NCWDMS pilot, and updates regarding the upcoming AFCARS 2020 reporting period.

Metadata-only record linking to the original dataset. Open original dataset below.
Hospital Cost Report Audited Data: 2021

This version of the Institutional Cost Report (ICR) has been audited by a Certified Public Accounting Firm. The ICR is a uniform report completed by New York State hospitals to report income, expenses, assets, liabilities, and statistics to the Department of Health (DOH). Under DOH regulations, (Part 86-1.2), Article 28 hospitals are required to file financial and statistical data with DOH annually. The data filed is part of the ICR and is received electronically through a secured network. This data is used to develop Medicaid rates, assist in the formulation of reimbursement methodologies, and analyze trends. For more information, check out: http://www.health.ny.gov/facilities/hospital/index.htm
Quality control and data-handling in multicentre studies: the case of the Multicentre Project for Tuberculosis Research

Background
          The Multicentre Project for Tuberculosis Research (MPTR) was a clinical-epidemiological study on tuberculosis carried out in Spain from 1996 to 1998. In total, 96 centres scattered all over the country participated in the project, 19935 "possible cases" of tuberculosis were examined and 10053 finally included. Data-handling and quality control procedures implemented in the MPTR are described.
        
        
          Methods
          The study was divided in three phases: 1) preliminary phase, 2) field work 3) final phase. Quality control procedures during the three phases are described. Results: Preliminary phase: a) organisation of the research team; b) design of epidemiological tools; training of researchers. Field work: a) data collection; b) data computerisation; c) data transmission; d) data cleaning; e) quality control audits; f) confidentiality. Final phase: a) final data cleaning; b) final analysis.
        
        
          Conclusion
          The undertaking of a multicentre project implies the need to work with a heterogeneous research team and yet at the same time attain a common goal by following a homogeneous methodology. This demands an additional effort on quality control.
CDC WONDER: Births

<p>The Births (Natality) online databases in CDC WONDER report birth rates, fertility rates and counts of live births  occurring within the United States to U.S. residents and non-residents. Counts can be obtained by state, county, child's sex and weight, mother's race, mother's age, mother's education, gestation period, prenatal care, birth plurality, and mother's medical and tobacco use risk factors. The data are derived from birth certificates.  Data are available since 1995. The data are produced by the National Center for Health Statistics.</p>
Use of a rapid arterial blood gas analyzer to estimate blood hemoglobin concentration among critically ill adults

Objective
          To evaluate whether measurement of the hemoglobin (Hb) concentration with a blood gas analyzer approximates that determined by a conventional coulter counter in critically ill adults.
        
        
          Design
          Prospective patient series.
        
        
          Setting
          A 32-bed cardiovascular, neurosurgical, trauma and medical-surgical intensive care unit in a single Canadian center.
        
        
          Patients
          We consecutively recruited 202 critically ill adults, the majority of whom had recent cardiac or vascular surgery, neurosurgery or trauma.
        
        
          Measurements
          The nurse obtained a single arterial blood sample within a few hours of the patient's admission to the intensive care unit. The Hb concentration was determined from each blood sample in a masked fashion, using both a blood gas analyzer and a conventional laboratory coulter counter.
        
        
          Main results
          A total of 202 consecutive paired analyses were conducted. There was a highly significant correlation between the coulter counter and blood gas analyzer methods of Hb measurement (r2 = 0.98, 95% confidence interval [CI] = 0.97–0.99; P < 0.0001). Using the method of Bland and Altman, the overall mean difference in Hb concentration between the coulter counter and the blood gas analyzer was -4.3 g/l (95% CI = -11.0 to 2.4). Of the 11 (5.4%) Hb measurements that extended beyond the upper and lower 95% CI, 10 (5.0%) were within ± 3 g/l of these confidence limits.
        
        
          Conclusions
          An arterial blood gas analyzer may provide a valid alternative method to the traditional coulter counter for the rapid assessment of Hb concentration among critically ill adults. Since issues related to its safety, quality control, data entry and cost savings have yet to be addressed, however, use of such point of care testing should be viewed as a supplement to conventional laboratory testing.
Compound 525849: N,N-Dimethyl-2-phenyl-N'-(3-ethoxyphenyl)-acetamidine

Chemical compound data from PubChem database. IUPAC Name: N'-(3-ethoxyphenyl)-N,N-dimethyl-2-phenylethanimidamide. Molecular Formula: C18H22N2O. Molecular Weight: 282.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Localities for 2024B

The CY 2024 Medicare Physician Fee Schedule has been updated by the annual PFS Final Rule for various new policies and for new and existing CPT/HCPCS codes.  For January 1, 2024, through March 8, 2024, the PFS conversion factor is $32.7442.  For March 9, 2024, through December 31, 2024, the CY 2024 Medicare Physician Fee Schedule has been updated by new legislation that revises the PFS conversion factor to $33.2875.
New York State Statewide COVID-19 Hospitalizations and Beds

This dataset includes information at the reporting facility level on patients hospitalized, admitted, discharged and fatalities.  It also includes information on staffed beds.  Patient information collected as part of the HERDS Hospital Survey are lab-confirmed COVID-19 positive. Hospitalized means patients admitted as inpatients in either inpatient or observation beds and does not include patients that were treated and released from an Emergency Department. The title of this dataset was initially the Hospital Electronic Response Data System (HERDS) Hospital Survey: COVID-19 Hospitalizations and Beds. The dataset was changed to its current title on 11/4/2021.
Drug Abuse Warning Network (DAWN-2010)

<p>The Drug Abuse Warning Network (DAWN) is a nationally representative public health surveillance system that has monitored drug related emergency department (ED) visits to hospitals since the early 1970s. First administered by the Drug Enforcement Administration (DEA) and the National Institute on Drug Abuse (NIDA), the responsibility for DAWN now rests with the Substance Abuse and Mental Health Services Administration's (SAMHSA) Center for Behavioral Health Statistics and Quality (CBHSQ). Over the years, the exact survey methodology has been adjusted to improve the quality, reliability, and generalizability of the information produced by DAWN. The current approach was first fully implemented in the 2004 data collection year.<br />
DAWN relies on a longitudinal probability sample of hospitals located throughout the United States. To be eligible for selection into the DAWN sample, a hospital must be a non-Federal, short-stay, general surgical and medical hospital located in the United States, with at least one 24-hour ED. DAWN cases are identified by the systematic review of ED medical records in participating hospitals. The unit of analysis is any ED visit involving recent drug use. DAWN captures both ED visits that are directly caused by drugs and those in which drugs are a contributing factor but not the direct cause of the ED visit. The reason a patient used a drug is not part of the criteria for considering a visit to be drug-related. Therefore, all types of drug-related events are included: drug misuse or abuse, accidental drug ingestion, drug-related suicide attempts, malicious drug poisonings, and adverse reactions. DAWN does not report medications that are unrelated to the visit.<br />
The DAWN public-use dataset provides information for all types of drugs, including illegal drugs, prescription drugs, over-the-counter medications, dietary supplements, anesthetic gases, substances that have psychoactive effects when inhaled, alcohol when used in combination with other drugs (all ages), and alcohol alone (only for patients aged 20 or younger). Public-use dataset variables describe and categorize up to 22 drugs contributing to the ED visit, including toxicology confirmation and route of administration. Administrative variables specify the type of case, case disposition, categorized episode time of day, and quarter of year.  Metropolitan area is included for represented metropolitan areas. Created variables include the number of unique drugs reported and case-level indicators for alcohol, non-alcohol illicit substances, any pharmaceutical, non-medical use of pharmaceuticals, and all misuse and abuse of drugs. Demographic items include age category, sex, and race/ethnicity. Complex sample design and weighting variables are included to calculate various estimates of drug-related ED visits for the Nation as a whole, as well as for specific metropolitan areas, from the ED visits classified as DAWN cases in the selected hospitals.This study has 1 Data Set.</p>