AndreaBozzo/ceres-open-data-index huggingface dataset:
MD COVID-19 - Cases by ZIP Code

<b>NOTE:</b> This dataset is no longer being updated as of 4/27/2023.
It is retired and no longer included in public COVID-19 data dissemination.

See this link for more information
https://imap.maryland.gov/pages/covid-data

<b>Summary</b>
The cumulative number of positive COVID-19 cases among Maryland residents within a single Maryland ZIP code.

<b>Description</b>
The MD COVID-19 - Cases by ZIP data layer is a collection of positive COVID-19 test results that have been reported each day by the local health department via the NEDSS system. Upon reaching a limit to the Socrata Platform, we decided to break the data into two parts. We now have "<a href="https://opendata.maryland.gov/d/ntd2-dqpx">MD COVID-19 - Cases by ZIP Code Archive (2022)</a>", "<a href="https://opendata.maryland.gov/Health-and-Human-Services/MD-COVID-19-Cases-by-ZIP-Code-Archive-2021-/5tie-utxw">MD COVID-19 - Cases by ZIP Code Archive (2021)</a>", and "<a href="https://opendata.maryland.gov/Health-and-Human-Services/MD-COVID-19-Cases-by-ZIP-Code-Archive-2020-/p4wa-abkc">MD COVID-19 - Cases by ZIP Code Archive (2020)</a>".

<b>Terms of Use</b>
The Spatial Data, and the information therein, (collectively the "Data") is provided "as is" without warranty of any kind, either expressed, implied, or statutory. The user assumes the entire risk as to quality and performance of the Data. No guarantee of accuracy is granted, nor is any responsibility for reliance thereon assumed. In no event shall the State of Maryland be liable for direct, indirect, incidental, consequential or special damages of any kind. The State of Maryland does not accept liability for any damages or misrepresentation caused by inaccuracies in the Data or as a result to changes to the Data, nor is there responsibility assumed to maintain the Data in any manner or form. The Data can be freely distributed as long as the metadata entry is not modified or deleted. Any data derived from the Data must acknowledge the State of Maryland in the metadata.

Case data aggregates to ZIP Codes do not reflect cases with missing, out of state, or incorrect ZIP Codes. Therefore, statewide totals of aggregate ZIP Code data may not match other statewide aggregate totals.
Compound 530168: Trimethylsilyl 2,4-bis(trimethylsilylamino)butanoate

Chemical compound data from PubChem database. IUPAC Name: trimethylsilyl 2,4-bis(trimethylsilylamino)butanoate. Molecular Formula: C13H34N2O2Si3. Molecular Weight: 334.68. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Somatic embryogenesis, rhizogenesis, and morphinan alkaloids production in two species of opium poppy

A study of somatic embryogenesis and rhizogenesis and their
influence on production of morphinan alkaloids on two species of opium poppy is presented. We identified the ratios of auxin and cytokinin that caused somatic embryogenesis and rhizogenesis in hypocotyl and cotyledons of Papaver somniferum album and Papaver orientale splendidissimum. The hypocotyls and cotyledons both show somatic embryogenesis in Papaver somniferum album whereas only the cotyledons were embryogenic in Papaver orientale splendidissimum. For rhizogenesis, the most
important response is on the cotyledons and leaves in these two species. Histology showed characteristic stages of somatic embryo: Globular, cotyledonous, and heart cotyledonary. High performance liquid chromatography analysis showed that the roots of both species synthesized codeine, thebaine, and papaverine. Morphine was only detected in aerial parts of Papaver
somniferum album. Codeine and thebaine were detected in the rhizogenous but no embryonic callus. These results suggest that root organogenesis is causally related to alkaloid biosynthesis.
Behavioral Health Barometer: Pennsylvania, 2014

This is a behavioral health report for the state of Pennsylvania. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment, and medicare enrollees for the years 2009 to 2013.
Patent AT-E40073-T1: [Translated] SCREW EXTRUDER.

An extrusion apparatus having a barrel (3) and a rotatable threaded screw (1) coaxially positioned therein is disclosed. The apparatus includes an upstream inlet section having an opening (13) therein for receiving material to be processed by the apparatus, a compression section (2) downstream of the inlet section, and a mixing or plasticizing section (7/8) downstream of the compression section. The interior surface of the barrel is provided with an undercut (12) therein which intercommunicates the feed opening with the compression section and has a portion thereof which extends downstream in the compression section about the interior surface of the barrel with a continuously decreasing cross-sectional area. The undercut may be formed in a cylindrical insert (9), carried within the barrel and, in an alternate embodiment, a second undercut cylindrical insert positioned about the first insert and rotatable relative thereto may be employed to vary the cross-sectional area of the undercut.
Compound 525452: 3-Methyl-4,6-dithiaoctane

Chemical compound data from PubChem database. IUPAC Name: 2-(ethylsulfanylmethylsulfanyl)butane. Molecular Formula: C7H16S2. Molecular Weight: 164.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Cytokine-stimulated T cells induce macrophage IL-10 production dependent on phosphatidylinositol 3-kinase and p70S6K: implications for rheumatoid arthritis

IL-10 is an anti-inflammatory cytokine produced in the joint in rheumatoid arthritis by macrophages and infiltrating blood lymphocytes. Regulation of its expression is poorly understood, but previous findings have suggested that physical interactions with T cells may play a role. This report investigates signalling mechanisms involved in the production of macrophage IL-10 upon interaction with fixed, cytokine-stimulated T cells (Tck). Elutriated monocytes were differentiated to macrophages by macrophage-colony-stimulating factor (M-CSF) and co-cultured with fixed T cells chronically stimulated in a cytokine cocktail of IL-2/IL-6/tumour necrosis factor (TNF)-α in the presence or absence of wortmannin and LY294002, inhibitors of phosphatidylinositol 3-kinase (PI3K), or of rapamycin, an inhibitor of p70 S6-kinase (p70S6K). Spontaneous IL-10 production by rheumatoid arthritis synovial-membrane mononuclear cells (RA-SMCs) and co-cultures of rheumatoid arthritis T cells (RA-Ts) and macrophages was also assessed. RA-T and Tck induction of macrophage IL-10 production was suppressed by cell separation and inhibition of PI3K and p70S6K. PI3K involvement was also shown by phosphorylation of the downstream effector protein kinase B. Spontaneous IL-10 production by RA-SMCs was also inhibited by LY294002 and depletion of the nonadherent (T-cell-enriched) fraction of the cell population. IL-10 production in RA-SMCs and M-CSF-primed macrophages, activated by interaction with Tck, is PI3K- and p70S6K-dependent.
Loratadine

Loratadine is an over-the-counter antihistamine used to relieve symptoms of allergies, such as runny nose, sneezing, and itchy eyes. It comes in 10 mg liquid-filled capsules taken orally once daily. This generic version is marketed by various brands like Allergy Relief and Wal-Itin. This information was generated using AI and is provided for informational and research purposes only.
Compound 525896: N,N-Dimethyl-N'-butyl-isobutyramidine

Chemical compound data from PubChem database. IUPAC Name: N'-butyl-N,N,2-trimethylpropanimidamide. Molecular Formula: C10H22N2. Molecular Weight: 170.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 530339: Eicosanoic acid, 18-methyl, methyl ester

Chemical compound data from PubChem database. IUPAC Name: methyl 18-methylhenicosanoate. Molecular Formula: C23H46O2. Molecular Weight: 354.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528833: Glycerol, 2,3-dimethyl, 1-(11-methyldodecanoate)

Chemical compound data from PubChem database. IUPAC Name: 2,3-dimethoxypropyl 11-methyldodecanoate. Molecular Formula: C18H36O4. Molecular Weight: 316.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 529408: 1-Phytene

Chemical compound data from PubChem database. IUPAC Name: 3,7,11,15-tetramethylhexadec-1-ene. Molecular Formula: C20H40. Molecular Weight: 280.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
2007 NSDUH Detailed Tables

These are the National Detailed Tables for the 2007 NSDUH.  The sections are:Illicit Drug Use Tables - 1.1 to 1.92Tobacco Product and Alcohol Use Tables - 2.1 to 2.84Risk and Protective Factors Tables - 3.1 to 3.24Incidence Tables - 4.1 to 4.16Dependence, Abuse, and Treatment Tables - 5.1 to 5.56Mental Health Tables - 6.1 to 6.41Miscellaneous Tables - 7.1 to 7.115Trend Tables - 8.1 to 8.42Sample Size and Population Tables - 9.1 to 9.13
Compound 526011: 1-(2-Allylphenoxy)-3-(2,2,2-trifluoro-N-isopropylacetamido)propan-2-yl 2,2,2-trifluoroacetate

Chemical compound data from PubChem database. IUPAC Name: [1-[propan-2-yl-(2,2,2-trifluoroacetyl)amino]-3-(2-prop-2-enylphenoxy)propan-2-yl] 2,2,2-trifluoroacetate. Molecular Formula: C19H21F6NO4. Molecular Weight: 441.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
The glial growth factors deficiency and synaptic destabilization hypothesis of schizophrenia

Background
          A systems approach to understanding the etiology of schizophrenia requires a theory which is able to integrate genetic as well as neurodevelopmental factors.
        
        
          Presentation of the hypothesis
          Based on a co-localization of loci approach and a large amount of circumstantial evidence, we here propose that a functional deficiency of glial growth factors and of growth factors produced by glial cells are among the distal causes in the genotype-to-phenotype chain leading to the development of schizophrenia. These factors include neuregulin, insulin-like growth factor I, insulin, epidermal growth factor, neurotrophic growth factors, erbB receptors, phosphatidylinositol-3 kinase, growth arrest specific genes, neuritin, tumor necrosis factor alpha, glutamate, NMDA and cholinergic receptors. A genetically and epigenetically determined low baseline of glial growth factor signaling and synaptic strength is expected to increase the vulnerability for additional reductions (e.g., by viruses such as HHV-6 and JC virus infecting glial cells). This should lead to a weakening of the positive feedback loop between the presynaptic neuron and its targets, and below a certain threshold to synaptic destabilization and schizophrenia.
        
        
          Testing the hypothesis
          Supported by informed conjectures and empirical facts, the hypothesis makes an attractive case for a large number of further investigations.
        
        
          Implications of the hypothesis
          The hypothesis suggests glial cells as the locus of the genes-environment interactions in schizophrenia, with glial asthenia as an important factor for the genetic liability to the disorder, and an increase of prolactin and/or insulin as possible working mechanisms of traditional and atypical neuroleptic treatments.
Instructions to update the SAMHSA SMI and SED Estimates URS Table 1: Number of Adults with Serious Mental Illness, age 18 and older, by State, 2014

These instructions explain how to update the 2014 Substance Abuse and Mental Health Services Administration (SAMHSA) Serious Mental Illness (SMI) and Serious Emotional Disturbances (SED) estimates. This includes obtaining the latest population data by state from the U.S. Census Bureau as well as the calculations and methodology necessary to create updated estimates.
Patent AT-E401586-T1: [Translated] DRAWER FOR HANDLING OPTICAL FIBERS

A system for management of optical fibers. The system has a housing including a back side and a front side. There are a plurality of drawers mounted in the housing. The drawers have a front and a back and are mounted so as to be moveable between a first position and a second position. The drawers are in the first position, the housing substantially blocks access to the back of the drawers. When the drawers are in the second position, there is access to the back of the drawers. The system also includes an array of fiber optic connectors mounted on a respective one of each of the drawers and an array of fiber optic splicing cassettes mounted on a respective one of each of the drawers.
Compound 530353: Methyl 2-methylbicyclo[2.2.1]hept-5-ene-2-carboxylate

Chemical compound data from PubChem database. IUPAC Name: methyl 2-methylbicyclo[2.2.1]hept-5-ene-2-carboxylate. Molecular Formula: C10H14O2. Molecular Weight: 166.22. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Nicotine

Nicotine Polacrilex is an over-the-counter medication available as oral lozenges in 2mg and 4mg strengths. It helps reduce nicotine withdrawal symptoms to aid smoking cessation by mimicking nicotine's effects without tobacco. Dissolve slowly in the mouth as directed. Common brands include Kirkland Signature, Equate, and Basic Care. This information was generated using AI and is provided for informational and research purposes only.
Atypical Herpes simplex keratitis (HSK) presenting as a perforated corneal ulcer with a large infiltrate in a contact lens wearer: multinucleated giant cells in the Giemsa smear offered a clue to the diagnosis

Purpose
          To report a case of atypical herpes simplex keratitis initially diagnosed as bacterial keratitis, in a contact lens wearer.
        
        
          Results
          Case report of an 18-year-old woman using contact lenses who presented with pain, redness and gradual decrease in vision in the right eye. Examination revealed a paracentral large stromal infiltrate with a central 2-mm perforation. Corneal and conjunctival scrapings were collected for microbiological investigations. Corneal tissue was obtained following penetrating keratoplasty. Corneal scraping revealed no microorganisms. Giemsa stained smear showed multinucleated giant cells. Conjunctival, corneal scrapings and tissue were positive for herpes simplex virus - 1 (HSV) antigen. Corneal tissue was positive for HSV DNA by PCR.
        
        
          Conclusions
          Atypical HSV keratitis can occur in contact lens wearers. A simple investigation like Giemsa stain may offer a clue to the diagnosis.
Excess Deaths Associated with COVID-19

Effective September 27, 2023, this dataset will no longer be updated. Similar data are accessible from wonder.cdc.gov.

Estimates of excess deaths can provide information about the burden of mortality potentially related to COVID-19, beyond the number of deaths that are directly attributed to COVID-19. Excess deaths are typically defined as the difference between observed numbers of deaths and expected numbers. This visualization provides weekly data on excess deaths by jurisdiction of occurrence. Counts of deaths in more recent weeks are compared with historical trends to determine whether the number of deaths is significantly higher than expected.

Estimates of excess deaths can be calculated in a variety of ways, and will vary depending on the methodology and assumptions about how many deaths are expected to occur. Estimates of excess deaths presented in this webpage were calculated using Farrington surveillance algorithms (1). For each jurisdiction, a model is used to generate a set of expected counts, and the upper bound of the 95% Confidence Intervals (95% CI) of these expected counts is used as a threshold to estimate excess deaths. Observed counts are compared to these upper bound estimates to determine whether a significant increase in deaths has occurred. Provisional counts are weighted to account for potential underreporting in the most recent weeks. However, data for the most recent week(s) are still likely to be incomplete. Only about 60% of deaths are reported within 10 days of the date of death, and there is considerable variation by jurisdiction. More detail about the methods, weighting, data, and limitations can be found in the Technical Notes.
Final Rule on Foster Care Legal Representation

The purpose of this Information Memorandum (IM) is to inform title IV-B and title IV-E agencies that the Administration for Children and Families (ACF) published a final rule for Foster Care Legal Representation on May 10, 2024 (89 FR 40400
  
  

). The final rule allows title IV-E agencies to claim FFP for administrative costs of legal and certain non-legal representation.

Metadata-only record linking to the original dataset. Open original dataset below.
Compound 529971: Ethane, 2-chloro-1-ethoxy-1-(2-methylpropyloxy)

Chemical compound data from PubChem database. IUPAC Name: 2-(2-chloro-1-ethoxyethoxy)propane. Molecular Formula: C7H15ClO2. Molecular Weight: 166.64. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
CDC WONDER API for Data Query Web Service

<p>WONDER online databases include county-level Compressed Mortality (death certificates) since 1979; county-level Multiple Cause of Death (death certificates) since 1999; county-level Natality (birth certificates) since 1995; county-level Linked Birth / Death records (linked birth-death certificates) since 1995;  state &amp; large metro-level United States Cancer Statistics mortality (death certificates) since 1999;  state &amp; large metro-level United States Cancer Statistics incidence (cancer registry cases) since 1999; state and metro-level Online Tuberculosis Information System (TB case reports) since 1993;  state-level Sexually Transmitted Disease  Morbidity (case reports) since 1984; state-level Vaccine Adverse Event Reporting system (adverse reaction case reports) since 1990; county-level population estimates since 1970.  The WONDER web server also hosts the Data2010 system with state-level data for compliance with Healthy People 2010 goals since 1998; the National Notifiable Disease Surveillance System weekly provisional case reports since 1996; the 122 Cities Mortality Reporting System weekly death reports since 1996;  the Prevention Guidelines database (book in electronic format) published 1998; the Scientific Data Archives (public use data sets and documentation); and links to other online data sources on the "Topics" page.</p>
Patent AT-E400980-T1: [Translated] FLAT HEATING PROFILE FOR DIRECT MEDIUM HEATING

The device (10) has at least one resistance heating element and a heat conducting flat envelope (20) enclosing the resistance heating element for outputting heat to the medium to be heated. At least one temperature detection element with electrical connections is arranged inside the envelope with its connections in a connection region (20c) of the envelope. The envelope edges are joined in a sealed manner.
Characterization of subcellular localization and stability of a splice variant of G alpha

Background
          Alternative mRNA splicing of αi2, a heterotrimeric G protein α subunit, has been shown to produce an additional protein, termed sαi2. In the sαi2 splice variant, 35 novel amino acids replace the normal C-terminal 24 amino acids of αi2. Whereas αi2 is found predominantly at cellular plasma membranes, sαi2 has been localized to intracellular Golgi membranes, and the unique 35 amino acids of sαi2 have been suggested to constitute a specific targeting signal.
        
        
          Results
          This paper proposes and examines an alternative hypothesis: disruption of the normal C-terminus of αi2 produces an unstable protein that fails to localize to plasma membranes. sαi2 is poorly expressed upon transfection of cultured cells; however, radiolabeling indicated that αi2 and sαi2 undergo myristoylation, a co-translational modification, equally well suggesting that protein stability rather than translation is affected. Indeed, pulse-chase analysis indicates that sαi2 is more rapidly degraded compared to αi2. Co-expression of βγ rescues PM localization and increases expression of sαi2. In addition, αi2A327S, a mutant previously shown to be unstable and defective in guanine-nucleotide binding, and αi2(1–331), in which the C-terminal 24 amino acids of αi2 are deleted, show a similar pattern of subcellular localization as sαi2 (i.e., intracellular membranes rather than plasma membranes). Finally, sαi2 displays a propensity to localize to potential aggresome-like structures.
        
        
          Conclusions
          Thus, instead of the novel C-terminus of sαi2 functioning as a specific Golgi targeting signal, the results presented here indicate that the disruption of the normal C-terminus of αi2 causes mislocalization and rapid degradation of sαi2.
A model for detecting the effects of vibration on peripheral blood flow

Exposure to hand-transmitted vibration (HTV) has been shown to result in cold-induced vasoconstriction and a reduction in blood flow to the hands and fingers of workers. Occupational exposure to HTV can also induce a hypersensitivity of the sympathetic nervous system to various stimuli, which in turn can result in vasoconstriction of the peripheral blood vessels and blanching of the skin because of reductions in peripheral blood flow. The data presented were collected using an established animal model of vibration-induced white finger (Welcome et al. 2008) to determine if changes in blood flow induced by vibration exposure could be used as a biomarker for the development of vibration-induced peripheral vascular disease. Two separate experiments were done. In Experiment 1, changes in blood flow were measured in the ventral tail artery of the rat tail before and after a 4 h exposure to tail vibration (frequency 125 Hz, amplitude 5 g). These data were compared with those of animals that were restrained and had t
Patent AT-E400687-T1: [Translated] REMOVABLE DETERGENT DISPENSING DEVICE FOR A TOP-LOADING WASHING MACHINE

This detergent products dispenser is characterized in that it is made in two parts ( 31  and  32 ) fitting together where one ( 31 ) includes the detergent products holding compartments ( 310  to  312 ) and liquid inlet and the detergent outlets and where the other ( 32 ) includes the water distribution baffles, the inlet edges ( 326  to  328 ) of the detergent compartments ( 310  to  312 ) and the siphons ( 323  to  325 ), The two parts ( 31 ) and ( 32 ) of the dispenser ( 30 ) constitutes a removable assembly recessed in a suitable seating arranged in the opening of the loading hopper ( 10 ).