AndreaBozzo/ceres-open-data-index huggingface dataset:
Cross-species hybridisation of pig RNA to human nylon microarrays

Background
          The objective of this research was to investigate the reproducibility of cross-species microarray hybridisation. Comparisons between same- and cross-species hybridisations were also made. Nine hybridisations between a single pig skeletal muscle RNA sample and three human cDNA nylon microarrays were completed. Three replicate hybridisations of two different amounts of pig RNA, and of human skeletal muscle RNA were completed on three additional microarrays.
        
        
          Results
          Reproducibility of microarray hybridisations of pig cDNA to human microarrays was high, as determined by Spearman and Pearson correlation coefficients and a Kappa statistic. Variability among replicate hybridisations was similar for human and pig data, indicating the reproducibility of results were not compromised in cross-species hybridisations. The concordance between data generated from hybridisations using pig and human skeletal muscle RNA was high, further supporting the use of human microarrays for the analysis of gene expression in the pig. No systematic effect of stripping and re-using nylon microarrays was found, and variability across microarrays was minimal.
        
        
          Conclusion
          The majority of genes generated highly reproducible data in cross-species microarray hybridisations, although approximately 6% were identified as highly variable. Experimental designs that include at least three replicate hybridisations for each experimental treatment will enable the variability of individual genes to be considered appropriately. The use of cross-species microarray analysis looks promising. However, additional validation is needed to determine the specificity of cross-species hybridisations, and the validity of results.
The human Y chromosome: the biological role of a “functional wasteland”

“Functional wasteland,” “Nonrecombining desert,” and
“Gene-poor chromosome” are only some examples of the different
definitions given to the Y chromosome in the last decade. In
comparison to the other chromosomes, the Y is poor in genes,
being more than 50% of its sequence composed of repeated
elements. Moreover, the Y genes are in continuous decay probably
due to the lack of recombination of this chromosome. But the
human Y chromosome, at the same time, plays a central role in
human biology. The presence or absence of this chromosome
determines gonadal sex. Thus, mammalian embryos with a Y
chromosome develop testes, while those without it develop ovaries
(Polani [1]). What is responsible for the male phenotype is
the testis-determining SRY gene (Sinclair [2]) which
remains the most distinguishing characteristic of this
chromosome. In addition to SRY, the presence of other genes with
important functions has been reported, including a region
associated to Turner estigmata, a gene related to the development
of gonadoblastoma and, most important, genes related to germ cell
development and maintenance and then, related with male fertility
(Lahn and Page [3]). This paper reviews the structure and
the biological functions of this peculiar chromosome.
Patent AT-E400913-T1: [Translated] DOOR WITH A SEAL FOR CLOSING A SWITCH PANEL OR CONTROL CABINET

The door has is provided with hinge elements (13) and closure elements along opposite side edges, the inside of the door panel (2) provided with a frame acting as a carrier for a door seal (12), with aligned openings for the hinge elements and the closure elements provided by the door panel and the frame. The fixings (19,20,21) for the hinge elements and the closure elements are used simultaneously for securing the frame to the inside of the door panel.
Cleveland-Elyria-Mentor, OH

This report presents combined 2005 to 2010 National Survey on Drug Use and Health (NSDUH) results for those aged 12 or older in the Cleveland-Elyria-Mentor, OH metro area. The report includes estimates of substance use disorder, major depressive episode, illicit drug use, marijuana use, cigarette use, binge alcohol use, and the nonmedical use of prescription-type pain relievers. Results are provided for the Cleveland-Elyria-Mentor metro area, Ohio, and the U.S. overall.
NNDSS - Table II. Chlamydia to Coccidioidomycosis

NNDSS - Table II. Chlamydia to Coccidioidomycosis - 2016.  In this Table, provisional* cases of selected† notifiable diseases (≥1,000 cases reported during the preceding year), and selected low frequency diseases are displayed. The Table includes total number of cases reported in the United States, by region and by states, in accordance with the current method of displaying MMWR data.  Data on United States exclude counts from US territories.
Note:
These are provisional cases of selected national notifiable diseases, from the National Notifiable Diseases Surveillance System (NNDSS). NNDSS data reported by the 50 states, New York City, the District of Columbia, and the U.S. territories are collated and published weekly as numbered tables printed in the back of the Morbidity and Mortality Weekly Report (MMWR). Cases reported by state health departments to CDC for weekly publication are provisional because of ongoing revision of information and delayed reporting. 

Case counts in this table are presented as they were published in the MMWR issues. Therefore, numbers listed in later MMWR weeks may reflect changes made to these counts as additional information becomes available. 

Footnotes:
C.N.M.I.: Commonwealth of Northern Mariana Islands. 
U: Unavailable.    -: No reported cases.    N: Not reportable.    NN: Not Nationally Notifiable.    NP:  Nationally notifiable but not published.  Cum: Cumulative year-to-date counts.    Med: Median.    Max: Maximum.

* Case counts for reporting year 2016 are provisional and subject to change. For further information on interpretation of these data, see http://wwwn.cdc.gov/nndss/document/ProvisionalNationaNotifiableDiseasesSurveillanceData20100927.pdf. Data for TB are displayed in Table IV, which appears quarterly. 
† Three low incidence conditions, rubella, rubella congenital, and tetanus, are in Table II to facilitate case count verification with reporting jurisdictions.
Death, autoantigen modifications, and tolerance

Autoantibodies present in the serum of patients with a variety of inflammatory diseases have proven useful as diagnostic markers and as probes with which to elucidate biochemical and signaling pathways. The mechanisms governing the generation of autoantibodies remain elusive, constituting a critical missing link in our understanding of rheumatologic illnesses. Several lines of experimentation in recent years have strongly implicated events surrounding cell death in this process. This review will address the potential role played by death-specific modifications of autoantigens in bypassing tolerance to highly conserved autoantigens, including nucleic acids, lipids, and proteins.
Compound 530163: N,N'o,o'-Tetra-(trimethylsilyl)cystine

Chemical compound data from PubChem database. IUPAC Name: trimethylsilyl 3-[[3-oxo-2-(trimethylsilylamino)-3-trimethylsilyloxypropyl]disulfanyl]-2-(trimethylsilylamino)propanoate. Molecular Formula: C18H44N2O4S2Si4. Molecular Weight: 529.0. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 525390: Isopropyl isobutyl disulfide

Chemical compound data from PubChem database. IUPAC Name: 2-methyl-1-(propan-2-yldisulfanyl)propane. Molecular Formula: C7H16S2. Molecular Weight: 164.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Miami - Dade Div: Drug-Related Emergency Department Visits, 2004-2011 - Adverse Reactions

Excel file with estimates, rates, relative standard errors, trends and confidence intervals, covering 2004-2011 for emergency department visits involving adverse reactions in the Miami metropolitan area, Dade County division. It includes ED visits in which an adverse health consequence (e.g., side effects or an allergic reaction) resulted when taking prescription drugs, over-the-counter medications, or dietary supplements as prescribed or recommended.  This analytic category does not include drug misuse or abuse.File includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol.  Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology.Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.
Compound 530613: 3-Cyclopentylpropionic acid, 2-methyloct-5-yn-4-yl ester

Chemical compound data from PubChem database. IUPAC Name: 2-methyloct-5-yn-4-yl 3-cyclopentylpropanoate. Molecular Formula: C17H28O2. Molecular Weight: 264.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E401377-T1: [Translated] HYBRID TOP COATS

Hybrid composition (I) comprises an inorganic binder (A) based on poly functional organosilane; (semi) metal alkoxides (B) or their hydrolysis- and condensation products; inorganic UV-absorber (C) such as particles of zinc oxide or cerium dioxide; organic polyol (D) with a hydroxyl functionality of greater than or equal to 2 and an average molecular weight of 250-10000 g/mol; and one or more solvents (E). Hybrid composition (I) comprises an inorganic binders (A) based on poly functional organosilane, which contain at least 2 silicon atoms with 1-3 alkoxy or hydroxy groups (where the silicon toms at bounded with at least a Si-C-bonding at a building unit linking the silicon unit); (semi) metal alkoxides (B) and their hydrolysis- and condensation products; inorganic UV-absorber (C) such as particles of zinc oxide or cerium dioxide in the form of particles, which exhibit at least 90% of an average particle diameter of less than or equal to 50 nm, measured by means of ultra centrifuge; organic polyol (D) with a hydroxyl functionality of greater than or equal to 2 and an average molecular weight of 250-10000 g/mol; and one or more solvents (E). Independent claims are also included for: (1) the preparation of (I); (2) a coating agent containing (I) and reactive cross-linker related to hydroxyl groups; and (3) a substrate coated with coatings, which is obtained using (I).
Compound 530082: 3-Methylhistidine, TMS

Chemical compound data from PubChem database. IUPAC Name: trimethylsilyl 3-(1-methylimidazol-4-yl)-2-(trimethylsilylamino)propanoate. Molecular Formula: C13H27N3O2Si2. Molecular Weight: 313.54. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Workforce Part 2 — A State’s Approach to Change

This Child Welfare Information Gateway Podcast is available on Apple Podcasts
  
  

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Metadata-only record linking to the original dataset. Open original dataset below.
Compound 525918: Npc155767

Chemical compound data from PubChem database. IUPAC Name: 17-(5-ethyl-6-methylheptan-2-yl)-10,13-dimethyl-2,7,8,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene. Molecular Formula: C29H48. Molecular Weight: 396.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Hedgehog signal transduction proteins: contacts of the Fused kinase and Ci transcription factor with the Kinesin-related protein Costal2

Background
          Hedgehog signaling proteins play important roles in development by controlling growth and patterning in various animals including Drosophila and mammals. Hedgehog signaling triggers changes in responsive cells through a novel transduction mechanism that ultimately controls the transcription of specific target genes via the activity of zinc finger transcription factors of the Cubitus interruptus /GLI family. In flies, key Hedgehog signal transduction components have been identified including the kinesin-related protein Costal2, the serinethreonine kinase Fused, and the PEST-containing protein Suppressor of Fused. These proteins control Cubitus interruptus cleavage, nucleo-cytoplasmic localization and activation. In fly embryos, Costal2, Fused, Suppressor of Fused and Cubitus interruptus are associated in at least one cytoplasmic complex, which interacts with the microtubules in a Hedgehog-dependent manner.
        
        
          Results
          Here we identified and mapped direct interactions between Cos2, Fu, and Ci using an in vitro affinity assay and the yeast two-hybrid system.
        
        
          Conclusions
          Our results provide new insights into the possible mechanism of the cytosolic steps of Hedgehog transduction.
NNDSS - Table II. Salmonellosis to Shigellosis

NNDSS - Table II. Salmonellosis to Shigellosis - 2014.In this Table, all conditions with a 5-year average annual national total of more than or equals 1,000 cases but less than or equals 10,000 cases will be displayed (��� 1,000 and ��_ 10,000). The Table includes total number of cases reported in the United States, by region and by states, in accordance with the current method of displaying MMWR data.  Data on United States exclude counts from US territories. Note:These are provisional cases of selected national notifiable diseases, from the National Notifiable Diseases Surveillance System (NNDSS). NNDSS data reported by the 50 states, New York City, the District of Columbia, and the U.S. territories are collated and published weekly as numbered tables printed in the back of the Morbidity and Mortality Weekly Report (MMWR). Cases reported by state health departments to CDC for weekly publication are provisional because of ongoing revision of information and delayed reporting. Case counts in this table are presented as they were published in the MMWR issues. Therefore, numbers listed in later MMWR weeks may reflect changes made to these counts as additional information becomes available. Footnotes:C.N.M.I.: Commonwealth of Northern Mariana Islands. U: Unavailable.    -: No reported cases.    N: Not reportable.    NN: Not Nationally Notifiable    Cum: Cumulative year-to-date counts.    Med: Median.    Max: Maximum. * Case counts for reporting years 2013 and 2014 are provisional and subject to change. For further information on interpretation of these data, see http://wwwn.cdc.gov/nndss/document/ProvisionalNationaNotifiableDiseasesSurveillanceData20100927.pdf. Data for TB are displayed in Table IV, which appears quarterly. ��� Includes E. coli O157:H7; Shiga toxin positive, serogroup non-O157; and Shiga toxin positive, not serogrouped.More information on NNDSS is available at http://wwwn.cdc.gov/nndss/.
Table 4. Perceptions of Great Risk of Smoking Marijuana Once a Month among Persons Aged 12 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2008, 2009, and 2010 NSDUHs

This table presents the 2008 to 2010 National Survey on Drug Use and Health (NSDUH) estimates of perceptions of great risk of having smoking marijuana once a month among those aged 12 or older by State and substate regions.
Molecular determinants and regulation of Leishmania virulence

A Leishmania model to explain microbial virulence in chronic infectious diseases is proposed. All these diseases progress from infection to symptomatic phase to host death or recovery. The outcome of each phase is depicted to result from the interactions of a distinct group of parasite molecules with a specific host immune compartment. The first group consists of invasive/evasive determinants, which are largely parasite cell surface and secreted molecules. Their activities help parasites establish infection by overcoming host immunologic and non-immunologic barriers. These determinants do not cause disease per se, but are indispensable for infection necessary for the development of a disease-state. The second group of parasite molecules consists of "pathoantigenic" determinants – unique parasite epitopes present often within otherwise highly conserved cytoplasmic molecules. Immune response against these determinants is thought to result in immunopathology manifested as clinical signs or symptoms, namely the virulent phenotype. The third group of parasite molecules is hypothetically perceived as vaccine determinants. Their interactions with the host immune system lead to the elimination or reduction of parasites to effect a clinical cure. Differential expression of these determinants alone by parasites may alter their interactions with the hosts. Virulent phenotype is consequently presented as a spectrum of manifestations from asymptomatic infection to fatality. A secondary level of regulation lies in host genetic and environmental factors. The model suggests that different parasite determinants may be targeted by different strategies to achieve more effective control of leishmaniasis and other similar diseases.
Compound 528990: Eicosane, 1,2-bis(methylthio)

Chemical compound data from PubChem database. IUPAC Name: 1,2-bis(methylsulfanyl)icosane. Molecular Formula: C22H46S2. Molecular Weight: 374.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528741: 3-Indoleacetic acid, TMS

Chemical compound data from PubChem database. IUPAC Name: trimethylsilyl 2-(1H-indol-3-yl)acetate. Molecular Formula: C13H17NO2Si. Molecular Weight: 247.36. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Critical advances in septicemia and septic shock

Recent advances suggest that toll-like receptors, various cytokines, cicosanoids, free radicals and macrophage migration inhibitory factor (MIF) play an important role in the pathobiology of septicemia and septic shock. Anti-MIF antibodies can decrease the plasma concentrations of tumor necrosis factor (TNF), lower bacterial circulating counts and enhance survival of animals with septicemia and septic shock. Monocyte expression of MHC-class II antigens, neutrophil expression of the integrin CD11b/CD18 and neutrophil activation can be related to the development of, and/or recovery from, post-operative sepsis. Thus, biological variations in the response of an individual to a given stimulus, appears to determine his/her ability or inability to develop and also recover from sepsis and septic shock. This suggests that it may be possible to predict the development of septicemia and septic shock in a given individual and take appropriate action both to prevent and treat them adequately.
Treatment Episode Data Set (TEDS): 1992-1997, National Admissions to Substance Abuse Treatment Services

This report presents data from the Treatment Episode Data Set (TEDS) for 1997, and trend data for 1992 to 1997. The report provides information on the demographic and substance abuse characteristics of people aged 12 and older admitted to treatment for abuse of alcohol and/or drugs in facilities that report to individual state administrative data systems.
Compound 529524: Glufosinate (AMPB), TBDMS

Chemical compound data from PubChem database. IUPAC Name: [tert-butyl(dimethyl)silyl] 2-[[tert-butyl(dimethyl)silyl]amino]-4-[[tert-butyl(dimethyl)silyl]oxy-methylphosphoryl]butanoate. Molecular Formula: C23H54NO4PSi3. Molecular Weight: 523.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E401651-T1: [Translated] SPACER ELEMENT AND FUEL UNIT FOR A NUCLEAR PLANT

The invention refers to a spacer for holding a number if elongated fuel rods intended to be located in a nuclear plant and to a fuel unit having such spacers. The spacer encloses a number of cells, which each has a longitudinal axis and is arranged to receive a fuel rod in such a way that the fuel rod extends in parallel with the longitudinal axis. Each cell is formed by a sleeve-like member. Each sleeve-like member is manufactured in a sheet-shaped material that is bent to the sleeve-like shape.
2011 CMHS Uniform Reporting System (URS) Output Tables for Ohio

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2011. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
NNDSS - Table II. Ehrlichiosis/Anaplasmosis

NNDSS - Table II. Ehrlichiosis/Anaplasmosis - 2016.  In this Table, provisional* cases of selected† notifiable diseases (≥1,000 cases reported during the preceding year), and selected low frequency diseases are displayed. The Table includes total number of cases reported in the United States, by region and by states, in accordance with the current method of displaying MMWR data.  Data on United States exclude counts from US territories. 

Note:
These are provisional cases of selected national notifiable diseases, from the National Notifiable Diseases Surveillance System (NNDSS). NNDSS data reported by the 50 states, New York City, the District of Columbia, and the U.S. territories are collated and published weekly as numbered tables printed in the back of the Morbidity and Mortality Weekly Report (MMWR). Cases reported by state health departments to CDC for weekly publication are provisional because of ongoing revision of information and delayed reporting. 

Case counts in this table are presented as they were published in the MMWR issues. Therefore, numbers listed in later MMWR weeks may reflect changes made to these counts as additional information becomes available. 

Footnotes:
C.N.M.I.: Commonwealth of Northern Mariana Islands. 
U: Unavailable.    -: No reported cases.    N: Not reportable.    NN: Not Nationally Notifiable.   NP:  Nationally notifiable but not published.   Cum: Cumulative year-to-date counts.    Med: Median.    Max: Maximum.
 
* Case counts for reporting year 2016 are provisional and subject to change. For further information on interpretation of these data, see http://wwwn.cdc.gov/nndss/document/ ProvisionalNationaNotifiableDiseasesSurveillanceData20100927.pdf. Data for TB are displayed in Table IV, which appears quarterly. 
† Three low incidence conditions, rubella, rubella congenital, and tetanus, are in Table II to facilitate case count verification with reporting jurisdictions. 
§ Please refer to the MMWR publication for weekly updates to the footnote for this condition.
Compound 528930: Benzaldehyde, 2-hydroxy, 5-ethyl, oxime, TMS

Chemical compound data from PubChem database. IUPAC Name: 1-(5-ethyl-2-trimethylsilyloxyphenyl)-N-trimethylsilyloxymethanimine. Molecular Formula: C15H27NO2Si2. Molecular Weight: 309.55. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.