AndreaBozzo/ceres-open-data-index huggingface dataset:
Patent AT-E400841-T1: [Translated] PROCEDURE FOR SECURE SOFTWARE UPDATES IN A SECURITY MODULE

The method involves forming an updating program block (PBI) and determining a target memory zone of a safety mobile. Pre-stored contents in the target zone are determined, and the pre-stored contents and the program block are combined to form a program code (SBI). The program code is transmitted to the mobile and the target memory of the updating block is obtained by inverse mixing of the contents and the block.
Compound 528206: Benzoic acid, 2-hydroxy-3-methoxycarbonyl, DTBS

Chemical compound data from PubChem database. IUPAC Name: methyl 2,2-ditert-butyl-4-oxo-1,3,2-benzodioxasiline-8-carboxylate. Molecular Formula: C17H24O5Si. Molecular Weight: 336.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 530119: 5-Mercaptouracil, TMS

Chemical compound data from PubChem database. IUPAC Name: trimethyl-(2-trimethylsilyloxy-5-trimethylsilylsulfanylpyrimidin-4-yl)oxysilane. Molecular Formula: C13H28N2O2SSi3. Molecular Weight: 360.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
To what degree does cognitive impairment in Alzheimer's disease predict dependence of patients on caregivers?

Background
          Patients with Alzheimer's disease experience a progressive loss of cognitive function, and the ability to independently perform activities of daily life. Sometimes a dependent stage is reached quite early in the disease, when caregivers decide that the patients can no longer be left alone safely. This is an important aspect of Alzheimer's for patients, their families, and also health care providers. Understanding the relationship between a patient's current cognitive status and their need for care may assist clinicians when recommending an appropriate management plan. In this study, we investigated the relationship of cognitive function to dependence on caregivers before the patients reach a severe stage of the disease.
        
        
          Methods
          Data were obtained on 1,289 patients with mild-to-moderate Alzheimer's disease studied in two randomised clinical trials of galantamine (Reminyl®). Cognition was assessed using the cognitive part of the Alzheimer's Disease Assessment Scale (ADAS-cog) and Mini-Mental State Examination (MMSE). Patients were considered dependent if they required >12 hours of supervision each day or had high care needs. The Disability Assessment for Dementia (DAD) scale was also used as a measure of dependence. Disability was predicted directly using MMSE and ADAS-cog and compared to predictions from converted scores.
        
        
          Results
          The odds ratio of dependence was significantly higher amongst the patients with worse cognitive impairment, adjusting for age, gender and antipsychotic medication use. For example, a 4-point difference in ADAS-cog score was associated with an increase of 17% (95% CI 11–23) in the adjusted odds for >12 hours of supervision, and of 35% (95% CI 28–43) for dependence. Disability predicted directly using actual ADAS-cog and scores converted from MMSE values had close agreement using the models developed.
        
        
          Conclusion
          In patients with mild-to-moderate Alzheimer's disease, even relatively small degrees of poorer cognitive function increased the risk of losing the ability to live independently.
Compound 529867: 2-(2-Furfuryl)pyrazine

Chemical compound data from PubChem database. IUPAC Name: 2-(furan-2-ylmethyl)pyrazine. Molecular Formula: C9H8N2O. Molecular Weight: 160.17. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E401232-T1: [Translated] SIDE PART FOR A ROOF OF A MOTOR VEHICLE BODY, AND MOTOR VEHICLE HAVING SUCH A SIDE PART

The body element (1) has a reinforcing element (6) and two identical handle supports (5) disposed at positions convenient to vehicles having two lateral doors as well as to vehicles having four lateral doors. One of the positions is practical for a passenger or a driver seated on front seats of the vehicle and another position is practical for passengers seated on rear seats of the vehicle. The supports are welded on the body element and are conformed for receiving handles. An independent claim is also included for a motor vehicle comprising a body element.
Pennsylvania (PA)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Pennsylvania for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.
The GOLD domain, a novel protein module involved in Golgi function and secretion

Background
          Members of the p24 (p24/gp25L/emp24/Erp) family of proteins have been shown to be critical components of the coated vesicles that are involved in the transportation of cargo molecules from the endoplasmic reticulum to the Golgi complex. The p24 proteins form hetero-oligomeric complexes and are believed to function as receptors for specific secretory cargo.
        
        
          Results
          Using sensitive sequence-profile analysis methods, we identified a novel β-strand-rich domain, the GOLD (Golgi dynamics) domain, in the p24 proteins and several other proteins with roles in Golgi dynamics and secretion. This domain is predicted to mediate diverse protein-protein interactions. Other than in the p24 proteins, the GOLD domain is always found combined with lipid- or membrane-association domains such as the pleckstrin homology (PH), Sec14p and FYVE domains.
        
        
          Conclusions
          The identification of the GOLD domain could aid in directed investigation of the role of the p24 proteins in the secretion process. The newly detected group of GOLD-domain proteins, which might simultaneously bind membranes and other proteins, point to the existence of a novel class of adaptors that could have a role in the assembly of membrane-associated complexes or in regulating assembly of cargo into membranous vesicles.
Impact of renal dysfunction on weaning from prolonged mechanical ventilation

Background:
          In the intensive care unit (ICU) setting, the combination of mechanical ventilation and renal replacement therapy (RRT) has been associated with prolonged length of hospital stay, high cost of care and poor outcome. We gathered outcome data on patients who had severe renal dysfunction on transfer to our regional weaning center (RWC) for attempted weaning from prolonged mechanical ventilation (PMV). We screened the admission laboratory values of 1077 patients transferred to our RWC over an 8-year period. We reviewed the medical records of patients with serum creatinine > 2.5 mg/dl.
        
        
          Results:
          Sixty-three patients met screening criteria and 40 patients were on RRT at the time of transfer. Eighteen patients had begun chronic RRT at least 2 months prior to admission to the transferring hospital for their current illness. Twenty-two patients had RRT initiated at the transferring hospital. Ten patients had RRT initiated at the RWC; eight patients had improvement or resolution of azotemia at our facility. RRT was withheld at patient/family request in five patients with progressive renal failure. None of the 50 patients who received RRT recovered renal function during treatment at our RWC. Intermittent hemodialysis was the standard RRT at the RWC. Duration of mechanical ventilation prior to transfer to the RWC was 49.7 ± 33.5 days (mean ± SD).
          Outcome of weaning attempts in the 63 patients was as follows: 13% weaned, 3% failed to wean and 84% died. These outcomes were significantly worse (P<0.001) than those in the 1014 patients whose admission serum creatinine was ≤ 2.5 mg/dl (58% weaned, 15% failed to wean, 27% died). The five patients in whom RRT was withheld were predominantly in progressive multisystem organ failure, and were unlikely to have survived regardless of RRT. From the study cohort, only one of the 10 patients discharged alive returned home, in contrast to 42% of the control group. No patient with severe renal dysfunction survived to 1 year post-discharge, compared to a 1-year survival of 38% in the control group (P = 0.029). Only four of the 10 patients survived more than 1 month, with the longest survival being 122 days.
        
        
          Conclusions:
          Patients who require PMV and RRT have a very poor prognosis. The small number of patients with renal insufficiency not requiring RRT had a more favorable hospital outcome and mortality, but long-term survival remained poor.
Compound 528842: Glycerol, 2,3-dimethyl, 1-heptadecanoate

Chemical compound data from PubChem database. IUPAC Name: 2,3-dimethoxypropyl heptadecanoate. Molecular Formula: C22H44O4. Molecular Weight: 372.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
2013 CMHS Uniform Reporting System (URS) Table for Wisconsin

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for Wisconsin for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
Compound 526301: 1,6-Dibromo-dibenzofuran

Chemical compound data from PubChem database. IUPAC Name: 1,6-dibromodibenzofuran. Molecular Formula: C12H6Br2O. Molecular Weight: 325.98. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 525416: 2-Methyl-4-ethyl-3,5-dithiahexane

Chemical compound data from PubChem database. IUPAC Name: 1-methylsulfanyl-1-propan-2-ylsulfanylpropane. Molecular Formula: C7H16S2. Molecular Weight: 164.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
ACF Parent Engagement Report 2024

The Administration for Children and Families (ACF) promotes the economic and social well-being of children, families, and communities across the country. As part of this mission, ACF actively listens to and engages with those it serves to ensure the compassionate and effective delivery of human services. The ACF Parent Engagement Report summarizes recent listening sessions ACF held with parents and caregivers from diverse backgrounds who have a range of experiences with ACF programs. The report shares a glimpse into the insights that parents shared from each of these listening sessions and highlights a few examples of how ACF has been and continues to be responsive to their feedback and recommendations.

Metadata-only record linking to the original dataset. Open original dataset below.
A role of proton transfer in peroxidase-catalyzed process elucidated by substrates docking calculations

Background
          Previous kinetic investigations of fungal-peroxidase catalyzed oxidation of N-aryl hydroxamic acids (AHAs) and N-aryl-N-hydroxy urethanes (AHUs) revealed that the rate of reaction was independent of the formal redox potential of substrates. Moreover, the oxidation rate was 3–5 orders of magnitude less than for oxidation of physiological phenol substrates, though the redox potential was similar.
        
        
          Results
          To explain the unexpectedly low reactivity of AHAs and AHUs we made ab initio calculations of the molecular structure of the substrates following in silico docking in the active center of the enzyme.
        
        
          Conclusions
          AHAs and AHUs were docked at the distal side of heme in the sites formed by hydrophobic amino acid residues that retarded a proton transfer and finally the oxidation rate. The analogous phenol substrates were docked at different sites permitting fast proton transfer in the relay of distal His and water that helped fast substrate oxidation.
CMS Program Statistics - Medicare Part D Enrollment

The CMS Program Statistics - Medicare Part D Enrollment tables provide data on characteristics of the Medicare Part D covered population. 

For additional information on enrollment, providers, and Medicare use and payment, visit the CMS Program Statistics page.

 

Below is the list of tables:


	MDCR ENROLL D 1. Medicare Part D Enrollment: Part D Enrollees by Type of Plan, Low Income Subsidy (LIS), and Retiree Drug Subsidy, Yearly Trend
	MDCR ENROLL D 2. Medicare Part D Enrollment: Part D Enrollees by Type of Plan, Low Income Subsidy (LIS), and Retiree Drug Subsidy, by Demographic Characteristics
	MDCR ENROLL D 3. Medicare Part D Enrollment: Part D Enrollees by Type of Plan, Low Income Subsidy (LIS), and Retiree Drug Subsidy, by Area of Residence
Effects of antimicrobial chemical exposures on influenza vaccination and antiviral immunity

Healthcare workers concurrently may be at a higher risk of developing respiratory infections and allergic disease, such as asthma, than the general public. Increased incidence of allergic diseases is thought to be caused, in part, due to occupational exposure to chemicals that induce or augment Th2 immune responses. However, whether exposure to these chemical antimicrobials can influence immune responses to respiratory pathogens is unknown. Here, we use a BALB/c murine model to test if the Th2-promoting antimicrobial chemical triclosan influences immune responses to influenza A virus. Mice were dermally exposed to 2% triclosan for 7 days prior to infection with a sub-lethal dose of mouse adapted PR8 A(H1N1) virus (50 pfu); triclosan exposure continued until 10 days post infection (dpi). Infected mice exposed to triclosan did not show an increase in morbidity or mortality, and viral titers were unchanged. Assessment of T cell responses at 10 dpi showed a decrease in the number of total and activated (CD44hi) CD4+ and CD8+ T cells at the site of infection (BAL and lung) in triclosan exposed mice compared to controls. Influenza-specific CD4+ and CD8+ T cells were assessed using MHCI and MHCII tetramers, with reduced populations, although not reaching statistical significance at these sites following triclosan exposure. Reductions in the Th1 transcription factor T-bet were seen in both activated and tetramer+ CD4+ and CD8+ T cells in the lungs of triclosan exposed infected mice, indicating reduced Th1 polarization and providing a potential mechanism for numerical reduction in T cells. Overall, these results indicate that the immune environment induced by triclosan exposure has the potential to influence the developing immune response to a respiratory viral infection and may have implications for healthcare workers who may be at an increased risk for developing infectious diseases.
Compound 528005: Benzoic acid, 3,5-dinitro, allyl ester

Chemical compound data from PubChem database. IUPAC Name: prop-2-enyl 3,5-dinitrobenzoate. Molecular Formula: C10H8N2O6. Molecular Weight: 252.18. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Tamsulosin hydrochloride

Tamsulosin Hydrochloride is a generic prescription medication used to treat symptoms of an enlarged prostate, such as difficulty urinating. It comes as 0.4 mg oral capsules, manufactured by Exelan Pharmaceuticals, Inc. under application ANDA078801. Available in bottles of 90 or 500 capsules. This information was generated using AI and is provided for informational and research purposes only.
Table 23. 2011-2012 NSDUH Serious Mental Illness in the Past Year, by Age Group and State

Table 23. Serious Mental Illness in the Past Year, by Age Group and State: Percentages, Annual Averages Based on 2011 and 2012 NSDUHs. Results are provided by State and for four age groups: 18 to 25, 26 or older, 18 or older and all persons 18 or older.
Investigation of glutathione

Background
          Certain genes from the glutathione S-transferase superfamily have been associated with several cancer types. It was the objective of this study to determine whether alleles of the glutathione S-transferase zeta 1 (GSTZ1) gene are associated with the development of sporadic breast cancer.
        
        
          Methods
          DNA samples obtained from a Caucasian population affected by breast cancer and a control population, matched for age and ethnicity, were genotyped for a polymorphism of the GSTZ1 gene. After PCR, alleles were identified by restriction enzyme digestion and results analysed by chi-square and CLUMP analysis.
        
        
          Results
          Chi-squared analysis gave a χ2 value of 4.77 (three degrees of freedom) with P = 0.19, and CLUMP analysis gave a T1 value of 9.02 with P = 0.45 for genotype frequencies and a T1 value of 4.77 with P = 0.19 for allele frequencies.
        
        
          Conclusion
          Statistical analysis indicates that there is no association of the GSTZ1 variant and hence the gene does not appear to play a significant role in the development of sporadic breast cancer.
MicroRNA-Mediated Calcineurin Signaling Activation Induces CCL2, CCL3, CCL5, IL8 and Chemotactic Activities in 4,4’-Methylene Diphenyl Diisocyanate Exposed Macrophages

Occupational exposure to 4,4’-methylene diphenyl diisocyanate (MDI), the most widely used monomeric diisocyanate, is one of the leading causes of occupational asthma (OA). Pathophysiological mechanism(s) by which how MDI causes OA is still warranted to be elucidated. Alveolar macrophages are the most abundant immune cell type in the lung, and these cells serve as one of the first immune responders against inhaled pathogens, particles, stimuli, and chemical allergens such as dNCOs. Upon encountering outside stimuli, alveolar macrophages react by phagocytosis as well as producing and secreting different mediators such as cytokines, chemokines, and others, into the alveoli microenvironment to orchestrate the initiation of inflammatory/immune responses. Dysfunction of alveolar macrophages, including elevated production and secretion of pro-inflammatory cytokines and other immune mediators, has been shown to play an important role in asthma pathogenesis. In the clinical setting, the levels of many immune mediators produced by macrophages have been found elevated in the asthmatic airway. However, both the levels of these asthma-associated, macrophage-secreted inflammatory/immune mediators in MDI-OA patients’ airways and how expression of these mediators change in response to MDI exposure in alveolar macrophages are largely undetermined. Previously, we demonstrated a microRNA (miR)-206-3p and miR-381-3p mediated PPP3CA/Calcineurin signaling induced inducible nitric oxide synthase (iNOS) transcription in macrophages and bronchoalveolar lavage cells (BALCs) after acute MDI exposure; however, whether this mechanism participates in regulation of other asthma-associated mediators secreted by macrophages/BALCs after MDI exposure is currently unknown. The first aim of this study was to identify candidate asthma-associated, macrophage-secreted mediators that can be regulated after MDI exposure. After identified the candidate mediators can be regulated by MDI-exposure, we investigated the roles of miR-mediated calcineurin signaling in regulation of these candidate mediators’ expressions in relation to the exposure to MDI.
Patent AT-E401364-T1: [Translated] ORGANIC SILICATE POLYMER AND COMPREHENSIVE INSULATING FILM

The present invention relates to an organic silicate polymer prepared by mixing silane compound with organic solvent to prepare a first mixture, and hydrolyzing and condensing the first mixture by adding water and catalyst, the first mixture being selected from a group consisting of oxidized hydrosilane, cyclic siloxane, a second mixture of oxidized hydrosilane and silane or silane oligomer, and a third mixture of cyclic siloxane and silane or silane oligomer, a composition for forming an insulation film of semiconductor devices prepared by using the organic silicate polymer, a method for preparing an insulation film using the composition, and a semiconductor device comprising the insulation film.
Evidence for the involvement of G

Background
          Activation of the extracellular signal-regulated kinases ERK1 and ERK2 in hepatocytes by prostaglandin (PG)F2α was recently found to be inhibited by pertussis toxin (PTX) suggesting a role for Gi proteins.
        
        
          Results
          Targeting the Gi2α expression by a specific ribozyme inhibited the PGF2α -induced ERK1/2 activation in hepatocytes. On the other hand a non-cleaving form of the Gi2α ribozyme did not significantly decrease the ERK1/2 activation. In ribozyme-treated cells the Gi2α protein level was reduced, while the Gqα level was not affected thus confirming the specificity of the ribozyme.
        
        
          Conclusion
          The present data suggest an important role of Gi2 in PGF2α -induced ERK1/2 signaling in hepatocytes.
Compound 529260: 3-(Bromomethyl)-3-(chloromethyl)oxetane

Chemical compound data from PubChem database. IUPAC Name: 3-(bromomethyl)-3-(chloromethyl)oxetane. Molecular Formula: C5H8BrClO. Molecular Weight: 199.47. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.