AndreaBozzo/ceres-open-data-index huggingface dataset:
Compound 530111: 5,6-Dimethyladenine, TMS

Chemical compound data from PubChem database. IUPAC Name: 7,8-dimethyl-N-trimethylsilylpurin-6-amine. Molecular Formula: C10H17N5Si. Molecular Weight: 235.36. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Signal and noise in bridging PCR

Background
          In a variant of the standard PCR reaction termed bridging, or jumping, PCR the primer-bound sequences are originally on separate template molecules. Bridging can occur if, and only if, the templates contain a region of sequence similarity. A 3' end of synthesis in one round of synthesis that terminates in this region of similarity can prime on the other. In principle, Bridging PCR (BPCR) can detect a subpopulation of one template that terminates synthesis in the region of sequence shared by the other template. This study considers the sensitivity and noise of BPCR as a quantitative assay for backbone interruptions. Bridging synthesis is also important to some methods for computing with DNA.
        
        
          Results
          In this study, BPCR was tested over a 328 base pair segment of the E. coli lac operon and a signal to noise ratio (S/N) of approximately 10 was obtained under normal PCR conditions with Taq polymerase. With special precautions in the case of Taq or by using the Stoffel fragment the S/N was improved to 100, i.e. 1 part of cut input DNA yielded the same output as 100 parts of intact input DNA.
        
        
          Conclusions
          In the E. coli lac operator region studied here, depending on details of protocol, between 3 and 30% per kilobase of final PCR product resulted from bridging. Other systems are expected to differ in the proportion of product that is bridged consequent to PCR protocol and the sequence analyzed. In many cases physical bridging during PCR will have no informational consequence because the bridged templates are of identical sequence, but in a number of special cases bridging creates, or, destroys, information.
Compound 530261: 1,3,5-tris-(Hydroxymethyl) benzene, tris-TMS

Chemical compound data from PubChem database. IUPAC Name: [3,5-bis(trimethylsilyloxymethyl)phenyl]methoxy-trimethylsilane. Molecular Formula: C18H36O3Si3. Molecular Weight: 384.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Genetic modification of glaucoma associated phenotypes between AKXD-28/Ty and DBA/2J mice

Background
          Glaucoma is a common disease but its molecular etiology is poorly understood. It involves retinal ganglion cell death and optic nerve damage that is often associated with elevated intraocular pressure. Identifying genes that modify glaucoma associated phenotypes is likely to provide insights to mechanisms of glaucoma. We previously reported glaucoma in DBA/2J mice caused by recessive alleles at two loci, isa and ipd, that cause iris stromal atrophy and iris pigment dispersion, respectively. A approach for identifying modifier genes is to study the effects of specific mutations in different mouse strains. When the phenotypic effect of a mutation is modified upon its introduction into a new strain, crosses between the parental strains can be used to identify modifier genes. The purpose of this study was to determine if the effects of the DBA/2J derived isa and ipd loci are modified in strain AKXD-28/Ty.
        
        
          Results
          AKXD-28/Ty mice develop glaucoma characterized by intraocular pressure elevation, retinal ganglion loss, and optic nerve excavation. In AKXD-28/Ty, isa causes an iris stromal atrophy phenotype as in DBA/2J. However, the iris pigment dispersion phenotype associated with ipd in DBA/2J does not occur in AKXD-28/Ty. Additionally, a greater severity and speed of retinal and optic nerve damage following intraocular pressure elevation in AKXD-28/Ty compared to DBA/2J mice suggests that AKXD-28/Ty is more susceptible to pressure-induced cell death.
        
        
          Conclusions
          The consequences of the ipd and isa mutations are modified in the AKXD-28/Ty background. These strains provide a resource for the identification of modifier genes that modulate pigment dispersion and susceptibility to pressure-induced cell death.
Flt3+macrophage precursors commit sequentially to osteoclasts, dendritic cells and microglia

Macrophages, osteoclasts, dendritic cells, and microglia are highly specialized cells that belong to the mononuclear phagocyte system. Functional and phenotypic heterogeneity within the mononuclear phagocyte system may reveal differentiation plasticity of a common progenitor, but developmental pathways leading to such diversity are still unclear.
Daily Census Tract-Level PM2.5 Concentrations, 2011-2015

This dataset provides modeled predictions of PM2.5 levels from the EPA's Downscaler model. Data are at the census tract level for 2011-2015. These data are used by the CDC's National Environmental Public Health Tracking Network to generate air quality measures. Census tract-level datasets contain estimates of the mean predicted concentration and associated standard error. Please refer to the metadata attachment for more information.

Learn more about outdoor air quality on the Tracking Network's website: https://ephtracking.cdc.gov/showAirLanding.action.

By using these data, you signify your agreement to comply with the following requirements:
1. Use the data for statistical reporting and analysis only.
2. Do not attempt to learn the identity of any person included in the data and do not combine these data with other data for the purpose of matching records to identify individuals.
3. Do not disclose of or make use of the identity of any person or establishment discovered inadvertently and report the discovery to: trackingsupport@cdc.gov.
4. Do not imply or state, either in written or oral form, that interpretations based on the data are those of the original data sources and CDC unless the data user and data source are formally collaborating.
5. Acknowledge, in all reports or presentations based on these data, the original source of the data and CDC.
6. Suggested citation: Centers for Disease Control and Prevention. National Environmental Public Health Tracking Network. Web. Accessed: insert date. www.cdc.gov/ephtracking.
Compound 528593: 4-Hydroxymandelic acid, tris(O-t-butyldimethylsilyl)-

Chemical compound data from PubChem database. IUPAC Name: [tert-butyl(dimethyl)silyl] 2-[tert-butyl(dimethyl)silyl]oxy-2-[4-[tert-butyl(dimethyl)silyl]oxyphenyl]acetate. Molecular Formula: C26H50O4Si3. Molecular Weight: 510.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
The major transcription initiation site of the

Background
          The cyclin-dependent kinase inhibitor p27Kip1 is essential for proper control of cell cycle progression. The levels of p27Kip1 are regulated by several mechanisms including transcriptional and translational controls. In order to delineate the molecular details of these regulatory mechanisms it is important to identify the transcription initiation site within the p27Kip1 gene, thereby defining the promoter region of the gene and the 5'-untranslated region of the p27Kip1 mRNA. Although several previous studies have attempted to map p27Kip1 transcription start sites, the results vary widely for both the mouse and human genes. In addition, even though the mouse and human p27Kip1 gene sequences are very highly conserved, the reported start sites are notably different.
        
        
          Results
          In this report, using a method that identifies capped ends of mRNA molecules together with RNase protection assays, we demonstrate that p27Kip1 transcription is initiated predominantly from a single site which is conserved in the human and mouse genes. Initiation at this site produces a 5'-untranslated region of 472 nucleotides in the human p27Kip1 mRNA and 502 nucleotides in the mouse p27Kip1 mRNA. In addition, several minor transcription start sites were identified for both the mouse and human genes.
        
        
          Conclusions
          These results demonstrate that the major transcription initiation sites in the mouse and human p27Kip1 genes are conserved and that the 5'-UTR of the p27Kip1 mRNA is much longer than generally believed. It will be important to consider these findings when designing experiments to identify elements that are involved in regulating the cellular levels of p27Kip1.
Evaluating Niger's experience in strengthening supervision, improving availability of child survival drugs through cost recovery, and initiating training for Integrated Management of Childhood Illness (IMCI)

Background
          WHO and UNICEF have recently developed the "Integrated Management of Childhood Illness" (IMCI) as an efficient strategy to assist developing countries reduce childhood mortality. Early experience with IMCI implementation suggests that clinical training is essential but not sufficient for the success of the strategy. Attention needs to be given to strengthening health systems, such as supervision and drug supply.
        
        
          Results
          This paper presents results of evaluating an innovative approach for implementing IMCI in Niger. It starts with strengthening district level supervision and improving the availability of child survival drugs through cost recovery well before the beginning of IMCI clinical training. The evaluation documented the effectiveness of the initial IMCI clinical training and referral.
        
        
          Conclusions
          Strengthening supervision and assuring the availability of essential drugs need to precede the initiation of IMCI Clinical training. Longer term follow up is necessary to confirm the impact of the approach on IMCI preparation and implementation.
Patent AT-E400904-T1: [Translated] INTERCHANGEABLE FUEL CARTRIDGE, FUEL CELL UNIT WITH SAID FUEL CARTRIDGE FOR PORTABLE ELECTRONIC DEVICES AND CORRESPONDING DEVICE

A fuel cell assembly including a membrane electrode assembly, an anode plate, a cathode plate, a removable fuel cartridge, and a fuel delivery system. The assembly includes an anode, a cathode, and a polymer electrolyte membrane having a fuel side and an oxygen side. The fuel cartridge includes an expandable fuel bladder for receiving liquid fuel, an expandable pressure member in contact with the bladder for maintaining a positive pressure on the bladder, and a sealable exit port in fluid communication with the bladder. The fuel delivery system delivers fuel from the cartridge to the fuel side of the membrane. An Interface, Control, and Regulator Circuit for Fuel Cell Powered Electronic Device.
Compound 529213: Cyclohexanecarboxylic acid, DMTBS

Chemical compound data from PubChem database. IUPAC Name: [tert-butyl(dimethyl)silyl] cyclohexanecarboxylate. Molecular Formula: C13H26O2Si. Molecular Weight: 242.43. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 530283: 3-Methylbutyl 4-methylpentanoate

Chemical compound data from PubChem database. IUPAC Name: 3-methylbutyl 4-methylpentanoate. Molecular Formula: C11H22O2. Molecular Weight: 186.29. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E400855-T1: [Translated] SYSTEM AND METHOD FOR SECURE DATA STREAMING USING A VIRTUAL CHIP CARD

There is disclosed a process for encrypting a data stream to secure the data stream for single viewing and to protect copyrights of the data stream. Specifically, there is disclosed a process for protecting streaming multimedia, entertainment and communications in an Internet-type transmission. There is further disclosed a streaming server component operably connected with a streaming server that interacts with a client system that includes a virtual smart card to effect the inventive process.
Research Article: BMC Infectious Diseases

Background
          Pyrazinamide (PZA) is among the first-line drugs for the treatment of tuberculosis. In vitro, it kills semidormant mycobacteria only at low pH. The purpose of this study was to compare PZA resistance with pyrazinamidase (PZase) activity and the genotype to better understand the molecular basis of PZA resistance and to expand the profile of pncA mutations worldwide.
        
        
          Results
          Of the 28 tested strains of Mycobacterium tuberculosis, 6 were susceptible to PZA and positive for PZase activity and had no pncA mutations. Twenty-one strains were resistant to PZA and negative for PZase activity and had mutations in the pncA gene, including 15 point mutations, 5 insertions, and 2 deletions. One strain had no mutation in the pncA gene, even though it was resistant to PZA and negative for PZase activity. Three isolates had adenine to guanine point mutations in the -11 upstream region, making this the most common type of pncA mutations in this study, with at least two different RFLP patterns.
        
        
          Conclusion
          These data help in the understanding of the molecular basis of PZA resistance. An adenine to guanine point mutation in the -11 upstream region was the most common type of pncA mutation in our isolates. The results of pncA mutation analyses should be carefully interpreted for epidemiologic purposes.
Compound 529530: Methyl 3-amino-5-[(2-methoxy-2-oxoethyl)sulfanyl]-4-(trifluoromethyl)-2-thiophenecarboxylate

Chemical compound data from PubChem database. IUPAC Name: 1,6-difluorophenanthrene. Molecular Formula: C14H8F2. Molecular Weight: 214.21. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E399551-T1: [Translated] AIDS AND METHODS FOR THE TRANSDERMAL APPLICATION OF FELODIPINE

A method of effectively treating hypertension in humans is achieved by administering felodipine via a transdermal formulation. Preferably, the transdermal formulation is applied to the skin of the patient and maintained in contact with the skin for at least about 24 hours days, and preferably for about 3 to about 8 days.
2014 CMHS Uniform Reporting System (URS) Table for Michigan

2014 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Michigan. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
Aseptic meningitis in Germany associated with echovirus type 13

Background
          Echoviruses are the commonest cause of aseptic meningitis. Echovirus type 13 which has not been isolated in Germany over a long period of time was the predominant enterovirus serotype associated with different local outbreaks of aseptic meningitis in Germany in 2000.
        
        
          Methods
          Virus isolation was performed from cerebrospinal fluid and stools. In order to study the genetic relationship of echovirus type 13 isolates, sequence analysis of a part of VP1 (~300 nt) was carried out. Isolates from different geographic regions were compared to each other as well as to elder viruses (prototype strain from 1953, four isolates from 1965–1986).
        
        
          Results
          Overall, 55 isolates of echovirus type 13 were obtained from different parts of Germany. It was shown that the new isolated strains have a very high degree of homology on the nucleotide level (> 98%)) but differ significantly from the old strains (76–85%).
        
        
          Conclusions
          a) Rare enterovirus serotypes can cause serious illness.
          b) The molecular drift has also been shown for other enterovirus serotypes.
Compound 528406: 2-Methyl-4-propyloxazole

Chemical compound data from PubChem database. IUPAC Name: 2-methyl-4-propyl-1,3-oxazole. Molecular Formula: C7H11NO. Molecular Weight: 125.17. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 527192: (3S,3aR,6R,8aS)-3,7,7-Trimethyl-8-methylenehexahydro-1H-3a,6-methanoazulen-2(3H)-one

Chemical compound data from PubChem database. IUPAC Name: 2,7,7-trimethyl-6-methylidenetricyclo[6.2.1.01,5]undecan-3-one. Molecular Formula: C15H22O. Molecular Weight: 218.33. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 525178: Pentaethylene glycol, monoallyl ether, acetate

Chemical compound data from PubChem database. IUPAC Name: 2-[2-[2-[2-(2-prop-2-enoxyethoxy)ethoxy]ethoxy]ethoxy]ethyl acetate. Molecular Formula: C15H28O7. Molecular Weight: 320.38. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
2012 Uniform Reporting System (URS) Tables for Ohio

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2012. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
Metformin hydrochloride

Metformin Hydrochloride is a prescription medication used to manage type 2 diabetes by helping control blood sugar levels. Available as oral tablets in strengths of 500 mg, 850 mg, and 1000 mg, it's manufactured by Ascend Laboratories, LLC, and Heritage Pharmaceuticals Inc. This generic drug is approved under ANDA213320 and marketed starting August 25, 2025. This information was generated using AI and is provided for informational and research purposes only.
Patent AT-E400657-T1: [Translated] METHOD FOR SEPARATING EPOXY-ENANTIMER MIXTURES USING EPOXY HYDROLASE-PRODUCING MICROORGANISMS

A description is given of epoxide hydrolases from bacteria of the genus Streptomyces, a novel process for the enzymatic separation of epoxide enantiomeric mixtures, of a novel detection method for epoxide hydrolase activity, a screening method for detecting epoxide hydrolase activity and the use of bacteria of the genus Streptomyces and of the resultant epoxide hydrolases for enantioselective epoxide hydrolysis.
Prevention Agenda 2019-2024 Tracking Indicators: State Most Recent Data

There are two datasets related to the State Level Prevention Agenda Tracking Indicators posted on this site. Each dataset consists of 99 state-level health tracking indicators and sub-indicators for the Prevention Agenda 2019-2024: New York State’s Health Improvement Plan.  A health tracking indicator is a metric through which progress on a certain area of health improvement can be assessed.  The indicators are organized by the Priority Area of the Prevention Agenda as well as the Focus Area under each Priority Area.  Priority areas include Prevent Chronic Disease; Promote a Healthy and Safe Environment; Promote Healthy Women, Infants and Children; Promote Well-Being and Prevent Mental and Substance Use Disorders; and Communicable Diseases. The data sets also include indicators about major cross-cutting health outcomes and indicators of health disparities, organized into Health Status and Reduce Health Disparities. The most recent year dataset includes the most recent state level data for all indicators. The trend dataset includes the most recent state level data and historical data, where available. Each dataset also includes the Prevention Agenda 2024 state objectives for the indicators. Sub-indicators are included in these datasets to measure health disparities among racial, ethnic, and socioeconomic groups and persons with disabilities.
Tribal Courts and Child Welfare: Being Family Centered

This Child Welfare Information Gateway Podcast is available on Apple Podcasts
  
  

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Metadata-only record linking to the original dataset. Open original dataset below.
Gene-expression profile comparisons distinguish seven organs of maize

Relative mRNA levels from maize organs have been quantified by hybridization to maize arrays fabricated with 5,376 unique expressed sequence tag clones. mRNAs from embryos, three vegetative organs (leaf blades, leaf sheaths and roots), husk leaves and two types of floral organs (immature ears and silks) reveal that a majority of genes expressed in diverse organs with little difference in transcript levels.
The κB transcriptional enhancer motif and signal sequences of V(D)J recombination are targets for the zinc finger protein HIVEP3/KRC: a site selection amplification binding study

Background
          The ZAS family is composed of proteins that regulate transcription via specific gene regulatory elements. The amino-DNA binding domain (ZAS-N) and the carboxyl-DNA binding domain (ZAS-C) of a representative family member, named κB DNA binding and recognition component (KRC), were expressed as fusion proteins and their target DNA sequences were elucidated by site selection amplification binding assays, followed by cloning and DNA sequencing. The fusion proteins-selected DNA sequences were analyzed by the MEME and MAST computer programs to obtain consensus motifs and DNA elements bound by the ZAS domains.
        
        
          Results
          Both fusion proteins selected sequences that were similar to the κB motif or the canonical elements of the V(D)J recombination signal sequences (RSS) from a pool of degenerate oligonucleotides. Specifically, the ZAS-N domain selected sequences similar to the canonical RSS nonamer, while ZAS-C domain selected sequences similar to the canonical RSS heptamer. In addition, both KRC fusion proteins selected oligonucleoties with sequences identical to heptamer and nonamer sequences within endogenous RSS.
        
        
          Conclusions
          The RSS are cis-acting DNA motifs which are essential for V(D)J recombination of antigen receptor genes. Due to its specific binding affinity for RSS and κB-like transcription enhancer motifs, we hypothesize that KRC may be involved in the regulation of V(D)J recombination.
NCHS Research and Development Survey (RANDS) Round 3 Restricted File

The Research and Development Survey (RANDS) is a series of cross-sectional 
surveys from probability-sampled commercial survey panels which began in 2015. 
RANDS 3 was administered by the National Opinion Research Center (NORC) using the 
Amerispeak Panel in the spring of 2019 and contains existing questions from 
the National Health Interview Survey (NHIS) as well as embedded probe questions 
and split-panel experiments for cognitive evaluations.
Compound 529817: Heptanal, 2,4,6-trichlorophenyl hydrazone

Chemical compound data from PubChem database. IUPAC Name: 2,4,6-trichloro-N-(heptylideneamino)aniline. Molecular Formula: C13H17Cl3N2. Molecular Weight: 307.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.