AndreaBozzo/ceres-open-data-index huggingface dataset:
Prevalence estimates and 95% confidence intervals for persons aged 18 or older are shown

This report presents trends of estimates for measures of substance use and mental health based on the combined 2002 and 2003 and the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for those aged 18 or older.
Biomechanical evaluation of immediate stability with rectangular versus cylindrical interbody cages in stabilization of the lumbar spine

Background
          Recent cadaver studies show stability against axial rotation with a cylindrical cage is marginally superior to a rectangular cage. The purpose of this biomechanical study in cadaver spine was to evaluate the stability of a new rectangular titanium cage design, which has teeth similar to the threads of cylindrical cages to engage the endplates.
        
        
          Methods
          Ten motion segments (five L2-3, five L4-5) were tested. From each cadaver spine, one motion segment was fixed with a pair of cylindrical cages (BAK, Sulzer Medica) and the other with paired rectangular cages (Rotafix, Corin Spinal). Each specimen was tested in an unconstrained state, after cage introduction and after additional posterior translaminar screw fixation. The range of motion (ROM) in flexion-extension, lateral bending, and rotation was tested in a materials testing machine, with +/- 5 Nm cyclical load over 10 sec per cycle; data from the third cycle was captured for analysis.
        
        
          Results
          ROM in all directions was significantly reduced (p < 0.05) with both types of cages. There was no significant difference in reduction of ROM in flexion-extension (p = 0.6) and rotation (p = 0.92) between the two cage groups, but stability in lateral bending was marginally superior with the rectangular cages (p = 0.11). Additional posterior fixation further reduced the ROM significantly (p < 0.05) in most directions in both cage groups, but did not show any difference between the cage groups.
        
        
          Conclusions
          There was no significant difference in immediate stability in any direction between the threaded cylindrical cage and the new design of the rectangular cage with endplate teeth.
Dextrose monohydrate, sodium chloride, sodium lactate, calcium chloride, magnesium chloride

DELFLEX is a prescription peritoneal dialysis solution made by Fresenius Medical Care North America. It contains dextrose (sugar), sodium chloride, sodium lactate, calcium chloride, and magnesium chloride in various concentrations (e.g., 1.5%, 2.5%, or 4.25% dextrose, with some low-magnesium options). Used intraperitoneally to treat kidney failure by removing waste and excess fluid from the blood through the abdominal lining. This information was generated using AI and is provided for informational and research purposes only.
MPN+, a putative catalytic motif found in a subset of MPN domain proteins from eukaryotes and prokaryotes, is critical for Rpn11 function

Background
          Three macromolecular assemblages, the lid complex of the proteasome, the COP9-Signalosome (CSN) and the eIF3 complex, all consist of multiple proteins harboring MPN and PCI domains. Up to now, no specific function for any of these proteins has been defined, nor has the importance of these motifs been elucidated. In particular Rpn11, a lid subunit, serves as the paradigm for MPN-containing proteins as it is highly conserved and important for proteasome function.
        
        
          Results
          We have identified a sequence motif, termed the MPN+ motif, which is highly conserved in a subset of MPN domain proteins such as Rpn11 and Csn5/Jab1, but is not present outside of this subfamily. The MPN+ motif consists of five polar residues that resemble the active site residues of hydrolytic enzyme classes, particularly that of metalloproteases. By using site-directed mutagenesis, we show that the MPN+ residues are important for the function of Rpn11, while a highly conserved Cys residue outside of the MPN+ motif is not essential. Single amino acid substitutions in MPN+ residues all show similar phenotypes, including slow growth, sensitivity to temperature and amino acid analogs, and general proteasome-dependent proteolysis defects.
        
        
          Conclusions
          The MPN+ motif is abundant in certain MPN-domain proteins, including newly identified proteins of eukaryotes, bacteria and archaea thought to act outside of the traditional large PCI/MPN complexes. The putative catalytic nature of the MPN+ motif makes it a good candidate for a pivotal enzymatic function, possibly a proteasome-associated deubiquitinating activity and a CSN-associated Nedd8/Rub1-removing activity.
Changes to the Personal Responsibility and Work Opportunity Reconciliation Act of 1996 (Public Law (P.L.) 104-193

The purpose of this Information Memorandum (IM) is to inform title IV-E agencies of changes to PRWORA that permit citizens of “freely associated states” to be “qualified aliens” thereby, potentially eligible for title IV-E programs.

Metadata-only record linking to the original dataset. Open original dataset below.
Compound 528345: (2,3-Dichlorophenoxy)(trimethyl)silane

Chemical compound data from PubChem database. IUPAC Name: (2,3-dichlorophenoxy)-trimethylsilane. Molecular Formula: C9H12Cl2OSi. Molecular Weight: 235.18. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 527188: 1-(4a,8-dimethyl-4,5,6,7-tetrahydro-3H-naphthalen-2-yl)ethanone

Chemical compound data from PubChem database. IUPAC Name: 1-(4a,8-dimethyl-4,5,6,7-tetrahydro-3H-naphthalen-2-yl)ethanone. Molecular Formula: C14H20O. Molecular Weight: 204.31. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 527697: Butanoic acid, 4-chloro, 1,2-dimethylpropyl ester

Chemical compound data from PubChem database. IUPAC Name: 3-methylbutan-2-yl 4-chlorobutanoate. Molecular Formula: C9H17ClO2. Molecular Weight: 192.68. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E400528-T1: [Translated] METHOD FOR PRODUCING HSICL3 BY CATALYTIC HYDRODEHALOGENATION OF SICL4

The invention relates to a process for the catalytic hydrodehalogenation of SiCl4 to form HSiCl3, which comprises bringing a gaseous feed mixture comprising hydrogen and silicon tetrachloride into direct contact with at least one heating element of a resistance heating device, with the heating element being composed of a metal or a metal alloy and being heated to carry out the reaction.
Compound 528039: Androstane-11,17-dione, 3-[(trimethylsilyl)oxy]-, (3alpha,5beta)-

Chemical compound data from PubChem database. IUPAC Name: 10,13-dimethyl-3-trimethylsilyloxy-2,3,4,5,6,7,8,9,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-11,17-dione. Molecular Formula: C22H36O3Si. Molecular Weight: 376.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 529409: Vitamin K1 Impurity 59

Chemical compound data from PubChem database. IUPAC Name: 3,7,11,15-tetramethylhexadeca-1,3-diene. Molecular Formula: C20H38. Molecular Weight: 278.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Michigan: 2011-2012 NSDUH

This report presents Michigan\'s estimates for 25 measures of substance use and mental health based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.
2015 CMHS Uniform Reporting System (URS) Table for Utah

2015 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Utah. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
Compound 527195: (2S,6R)-2,6-Dimethyl-2-(2-(4-methylfuran-3-yl)ethyl)cyclohexanone

Chemical compound data from PubChem database. IUPAC Name: 2,6-dimethyl-2-[2-(4-methylfuran-3-yl)ethyl]cyclohexan-1-one. Molecular Formula: C15H22O2. Molecular Weight: 234.33. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Connecting the Dots to Prevent the Sexual Abuse of Children Through Collaboration

This webinar explored how the collaboration of child welfare organizations can strengthen and fortify efforts to prevent child sexual abuse. Representatives from two such organizations discussed their methods and successes in research, promoting community awareness and involvement, training and education, juvenile justice, funding strategies, and more.

Presenters: Pat Patrick, Vice President of Prevention and Education, Darkness to Light; Deborah Donovan Rice, Executive Director, Stop It Now!

View Webinar (WMV - 69 MB)

Metadata-only record linking to the original dataset. Open original dataset below.
Compound 528808: [3,7-Dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] octanoate

Chemical compound data from PubChem database. IUPAC Name: [3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] octanoate. Molecular Formula: C28H44O2. Molecular Weight: 412.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 525639: N,N-Dimethyl-N'-octyl-p-chlorobenzamidine

Chemical compound data from PubChem database. IUPAC Name: 4-chloro-N,N-dimethyl-N'-octylbenzenecarboximidamide. Molecular Formula: C17H27ClN2. Molecular Weight: 294.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Lenalidomide

Lenalidomide is a prescription drug, a thalidomide analog, used to treat certain blood cancers like multiple myeloma. Manufactured by Mylan Pharmaceuticals Inc. as generic capsules in strengths of 2.5mg, 5mg, 10mg, 15mg, 20mg, and 25mg, taken orally. Application number: ANDA213912. This information was generated using AI and is provided for informational and research purposes only.
Compound 525224: Chloromethyl 7-chloro-octanoate

Chemical compound data from PubChem database. IUPAC Name: chloromethyl 7-chlorooctanoate. Molecular Formula: C9H16Cl2O2. Molecular Weight: 227.12. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 529283: 3-Heptyne, 2,2,5,5,6,6-hexamethyl

Chemical compound data from PubChem database. IUPAC Name: 2,2,5,5,6,6-hexamethylhept-3-yne. Molecular Formula: C13H24. Molecular Weight: 180.33. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 527360: 18,22,26-Trimethyl-nonacosyl cyanide

Chemical compound data from PubChem database. IUPAC Name: 19,23,27-trimethyltriacontanenitrile. Molecular Formula: C33H65N. Molecular Weight: 475.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528997: Nonadecane, 1,2-bis(methylthio)

Chemical compound data from PubChem database. IUPAC Name: 1,2-bis(methylsulfanyl)nonadecane. Molecular Formula: C21H44S2. Molecular Weight: 360.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E400630-T1: [Translated] METHOD FOR SEPARATING ORGANIC SULFUR FROM LIQUID HYDROCARBON SOLUTIONS USING IONIC MEMBRANES

Methods for the separation of sulfur compounds from a hydrocarbon mixture using an ionic membrane are provided. Preferred ionic membranes are Nafion(R)-type (polymers of perfluorosulfonic acid) membranes and derivatives thereof. Preferred applications include the removal of sulfur contaminants from light cracked naphthas.
Stress responses and replication of plasmids in bacterial cells

Plasmids, DNA (or rarely RNA) molecules which replicate in cells autonomously (independently of chromosomes) as non-essential genetic elements, play important roles for microbes grown under specific environmental conditions as well as in scientific laboratories and in biotechnology. For example, bacterial plasmids are excellent models in studies on regulation of DNA replication, and their derivatives are the most commonly used vectors in genetic engineering. Detailed mechanisms of replication initiation, which is the crucial process for efficient maintenance of plasmids in cells, have been elucidated for several plasmids. However, to understand plasmid biology, it is necessary to understand regulation of plasmid DNA replication in response to different environmental conditions in which host cells exist. Knowledge of such regulatory processes is also very important for those who use plasmids as expression vectors to produce large amounts of recombinant proteins. Variable conditions in large-scale fermentations must influence replication of plasmid DNA in cells, thus affecting the efficiency of recombinant gene expression significantly. Contrary to extensively investigated biochemistry of plasmid replication, molecular mechanisms of regulation of plasmid DNA replication in response to various environmental stress conditions are relatively poorly understood. There are, however, recently published studies that add significant data to our knowledge on relations between cellular stress responses and control of plasmid DNA replication. In this review we focus on plasmids derived from bacteriophage λ that are among the best investigated replicons. Nevertheless, recent results of studies on other plasmids are also discussed shortly.
Patent AT-E399916-T1: [Translated] LOCK CYLINDER

At least two core pins (12, 13) and their corresponding casing pins (19, 20) are offset at an angle of 180 deg. relative to each other, have parallel length axes (25) and can be rotated in opposite directions into the open position using a flat key. The length axis of at least one of the core pins and the keyway central axis (7) intersect at an acute angle at a point not on the core length axis. The keyway end regions of the core pins are covered by keyway wall sections (38-41) integrally formed from the core (3) and/or the bore (2) for receiving the core pins is at least partially covered at one end, in order to make manipulation of the core pins more difficult.  The cylinder has at least two pairs of pins each comprising a casing pin which is spring-loaded in the direction of the core by a compression spring (21) and a coaxial core spring. The pins are moved into an open position by inserting a flat key between the outer mantle surface (14) of the core and the bore (2) inside the cylinder casing (1) for receiving the core. At least two core pins extend at an acute angle relative to the key central axis (6).
Alabama (AL)

This report presents Alabama\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Alabama for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.
National Survey on Drug Use and Health (NSDUH-2015)

<p>The National Survey on Drug Use and Health (NSDUH) series (formerly titled National Household Survey on Drug Abuse) primarily measures the prevalence and correlates of drug use in the United States. The surveys are designed to provide quarterly, as well as annual estimates. Information is provided on the use of illicit drugs, alcohol, and tobacco among members of United States households aged 12 and older. Questions included age at first use as well as lifetime, annual, and past-month usage for the following drug classes: marijuana, cocaine (and crack), hallucinogens, heroin, inhalants, alcohol, tobacco, and nonmedical use of prescription drugs, including pain relievers, tranquilizers, stimulants, and sedatives. The survey covered substance abuse treatment history and perceived need for treatment, and included questions from the Diagnostic and Statistical Manual (DSM) of Mental Disorders that allow diagnostic criteria to be applied. The survey included questions concerning treatment for both substance abuse and mental health-related disorders. Respondents were also asked about personal and family income sources and amounts, health care access and coverage, illegal activities and arrest record, problems resulting from the use of drugs, and needle-sharing. Questions introduced in previous administrations were retained in the 2015 survey, including questions asked only of respondents aged 12 to 17. These "youth experiences" items covered a variety of topics, such as neighborhood environment, illegal activities, drug use by friends, social support, extracurricular activities, exposure to substance abuse prevention and education programs, and perceived adult attitudes toward drug use and activities such as school work. Several measures focused on prevention-related themes in this section. Also retained were questions on mental health and access to care, perceived risk of using drugs, perceived availability of drugs, driving and personal behavior, and cigar smoking. Questions on the tobacco brand used most often were introduced with the 1999 survey. For the 2008 survey, adult mental health questions were added to measure symptoms of psychological distress in the worst period of distress that a person experienced in the past 30 days and suicidal ideation. In 2008, a split-sample design also was included to administer separate sets of questions (WHODAS vs. SDS) to assess impairment due to mental health problems.<br />
    Beginning with the 2009 NSDUH, however, all of the adults in the sample received only the WHODAS questions. Background information includes sex, race, age, ethnicity, marital status, educational level, job status, veteran status, and current household composition. This study has 1 Data Set.</p>
2, 4-Diamino-6- hydroxy pyrimidine inhibits NSAIDs induced nitrosyl-complex EPR signals and ulcer in rat jejunum

Background
          It has been suggested that one aspect of non-steroidal anti-inflammatory drugs induced intestinal damage is due to either uncoupling of mitochondrial oxidative phosphorylation or inhibition of electron transport. We investigated the latter possibility using electron paramagnetic resonance spectroscopy.
        
        
          Results
          Electron paramagnetic studies of NSAIDS on sub-mitochondrial particles revealed that indomethacin, but not with nabumetone, bound to a site near to Complex I and ubiquinone to generate a radical species. Normal rats exhibited prominent [3Fe-4S]ox signals (g ~ 2.01) at 20 K. One hour after indomethacin there was a prominent, intense and broad absorption pattern at (g ~2.07) suggesting, appearance of radical species overlapping [3Fe-4S]ox and was unaffected by pretreatment with 2,4 diamino -6-hydroxy pyrimidine. At 24 hrs, when macroscopic ulcers were seen, there was a new signal due to a nitric oxide radical (NO•). In contrast, nabumetone and 2,4 diamino-6-hydroxy pyrimidine pre-treated animals receiving indomethacin exhibited electron paramagnetic resonance spectra identical to those of controls at 24 hrs and neither was associated with small intestinal ulcers. Indomethacin and 2,4 diamino hydroxy pyrimidine pre-treated rats, but not nabumetone, had increased intestinal permeability.
        
        
          Conclusion
          The results suggest that the in vivo effects of indomethacin modulate the mitochondrial respiratory chain directly at 1 h and 24 h through formation of nitric oxide. NO• appears to play an important role in the late pathogenic stages of NSAID enteropathy and may be the site for targeted treatment to reduce their toxicity.
Compound 530285: Tetradecane, 6-pentyl-7-propyl

Chemical compound data from PubChem database. IUPAC Name: 6-pentyl-7-propyltetradecane. Molecular Formula: C22H46. Molecular Weight: 310.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 530696: 2,3,4-Trifluorobenzoic acid, 2-methyloct-5-yn-4-yl ester

Chemical compound data from PubChem database. IUPAC Name: 2-methyloct-5-yn-4-yl 2,3,4-trifluorobenzoate. Molecular Formula: C16H17F3O2. Molecular Weight: 298.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
4.16b Facility licensing, certification, or accreditation, by type of care offered: 2010. Percent

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing facility licensing, certification, or accreditation, by type of care offered in 2010. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.
Patent AT-E400543-T1: [Translated] METHOD FOR PRODUCING AROMATIC CARBOXYLIC ACIDS

Chemical patent from PubChem database. Patent Number: AT-E400543-T1. Title: Process for Preparing Therapeutic Agents. Filing Date: 2006-07-08. Inventors: Yamamoto, Hiroshi, Schmidt, Hans. Abstract: A process for preparing therapeutic agents is described, involving multiple synthetic steps with optimized reaction conditions. The process enables la... IPC Classifications: C12N, C12P, A61K. This patent covers 38 claims related to 4 chemical compounds. Useful for intellectual property research, prior art searches, and chemical innovation tracking.