AndreaBozzo/ceres-open-data-index huggingface dataset:
Oxygen and nitrate-dependent regulation of

Background
          Escherichia coli can respire anaerobically using dimethyl sulfoxide (DMSO) or trimethylamine-N-oxide (TMAO) as the terminal electron acceptor for anaerobic energy generation. Expression of the dmsABC genes that encode the membrane-associated DMSO/TMAO reductase is positively regulated during anaerobic conditions by the Fnr protein and negatively regulated by the NarL protein when nitrate is present.
        
        
          Results
          The regions of dmsA regulatory DNA required for Fnr and NarL interactions in response to anaerobiosis and nitrate, respectively, were examined. Mutations within the Fnr site that deviated from the wild type sequence, TTGATaccgAACAA, or that removed an entire half-site, either impaired or abolished the anaerobic activation of dmsA-lacZ expression. The region for phosphorylated NarL (NarL-phosphate) binding at the dmsA promoter was identified by DNase I and hydroxyl radical footprinting methods. A large 97 bp region that overlaps the Fnr and RNA polymerase recognition sites was protected by NarL-phosphate but not by the non-phosphorylated form of NarL. Hydroxyl radical footprinting analysis confirmed the NarL-phosphate DNase I protections of both dmsA strands and revealed 8–9 protected sites of 3–5 bp occurring at ten bp intervals that are offset by 3 bp in the 3' direction.
        
        
          Conclusion
          These findings suggest that multiple molecules of phosphorylated NarL bind along one face of the DNA and may interfere with Fnr and/or RNA polymerase interactions at the dmsA regulatory region. The interplay of these transcription factors insures a hierarchical expression of the dmsABC genes when respiration of the preferred electron acceptors, oxygen and nitrate, is not possible.
Compound 527543: 2,5-Dimethyl-1-prop-2-enylpyrrole

Chemical compound data from PubChem database. IUPAC Name: 2,5-dimethyl-1-prop-2-enylpyrrole. Molecular Formula: C9H13N. Molecular Weight: 135.21. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Identification and Characterisation of the Murine Homologue of the Gene Responsible for Cystinosis,

Background
          Cystinosis is an autosomal recessive disorder characterised by an intralysosomal accumulation of cystine, and affected individuals progress to end-stage renal failure before the age of ten. The causative gene, CTNS, was cloned in 1998 and the encoded protein, cystinosin, was predicted to be a lysosomal membrane protein.
        
        
          Results
          We have cloned the murine homologue of CTNS, Ctns, and the encoded amino acid sequence is 92.6% similar to cystinosin. We localised Ctns to mouse chromosome 11 in a region syntenic to human chromosome 17 containing CTNS. Ctns is widely expressed in all tissues tested with the exception of skeletal muscle, in contrast to CTNS.
        
        
          Conclusions
          We have isolated, characterised and localised Ctns, the murine homologue of CTNS underlying cystinosis. Furthermore, our work has brought to light the existence of a differential pattern of expression between the human and murine homologues, providing critical information for the generation of a mouse model for cystinosis.
Compound 525594: N,N-Dimethyl-N'-(4-ethoxyphenyl)-benzamidine

Chemical compound data from PubChem database. IUPAC Name: N'-(4-ethoxyphenyl)-N,N-dimethylbenzenecarboximidamide. Molecular Formula: C17H20N2O. Molecular Weight: 268.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 527116: Hex-2-en-1-yl 2-methylbutanoate

Chemical compound data from PubChem database. IUPAC Name: hex-2-enyl 2-methylbutanoate. Molecular Formula: C11H20O2. Molecular Weight: 184.27. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 525648: N,N-Dimethyl-N'-phenyl-p-methylbenzamidine

Chemical compound data from PubChem database. IUPAC Name: N,N,4-trimethyl-N'-phenylbenzenecarboximidamide. Molecular Formula: C16H18N2. Molecular Weight: 238.33. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
A critical appraisal of clinical practice guidelines for the treatment of lower-limb osteoarthritis

Clinical practice guidelines are important tools to assist clinical decision-making. Recently, several guidelines addressing the management of osteoarthritis (OA) have been published. Clinicians treating patients with OA must ensure that these guidelines are developed with consistency and methodological rigour. We undertook a qualitative summary and critical appraisal of six medical treatment guidelines for the management of lower-limb OA published in the medical literature within the past 5 years. A review of these six guidelines revealed that each possesses strengths and weakness. While most described the scope and intended patient populations, the guidelines varied considerably in the rigour of their development, coverage of implementation issues, and disclosure of conflicts of interest.
Clindamycin palmitate hydrochloride

Clindamycin Palmitate Hydrochloride is an oral antibiotic used to treat bacterial infections. It comes as a granule for solution, with each 5 mL providing 75 mg of clindamycin base. Manufactured by Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc., it's a prescription drug approved under ANDA207047. This information was generated using AI and is provided for informational and research purposes only.
An examination of the Apo-1/Fas promoter Mva I polymorphism in Japanese patients with multiple sclerosis

Background
          The Apo-1/Fas (CD95) molecule is an apoptosis-signaling cell surface receptor belonging to the tumor necrosis factor (TNF) receptor family. Both Fas and Fas ligand (FasL) are expressed in activated mature T cells, and prolonged cell activation induces susceptibility to Fas-mediated apoptosis. The Apo-1/Fas gene is located in a chromosomal region that shows linkage in multiple sclerosis (MS) genome screens, and studies indicate that there is aberrant expression of the Apo-1/Fas molecule in MS.
        
        
          Methods
          Mva I polymorphism on the Apo-1/Fas promoter gene was detected by PCR-RFLP from the DNA of 114 Japanese patients with conventional MS and 121 healthy controls. We investigated the association of the Mva I polymorphism in Japanese MS patients using a case-control association study design.
        
        
          Results
          We found no evidence that the polymorphism contributes to susceptibility to MS. Furthermore, there was no association between Apo-1/Fas gene polymorphisms and clinical course (relapsing-remitting course or secondary-progressive course). No significant association was observed between Apo-1/Fas gene polymorphisms and the age at disease onset.
        
        
          Conclusions
          Overall, our findings suggest that Apo-1/Fas promoter gene polymorphisms are not conclusively related to susceptibility to MS or the clinical characteristics of Japanese patients with MS.
Fundamental deficiencies in the megatrial methodology

The fundamental methodological deficiency of megatrials is deliberate reduction of experimental control in order to maximize recruitment and compliance of subjects. Hence, typical megatrials recruit pathologically and prognostically heterogeneous subjects, and protocols typically fail to exclude significant confounders. Therefore, most megatrials do not test a scientific hypothesis, nor are they informative about individual patients. The proper function of a megatrial is precise measurement of effect size for a therapeutic intervention. Valid megatrials can be designed only when simplification can be achieved without significantly affecting experimental control. Megatrials should be conducted only at the end of a long process of therapeutic development, and must always be designed and interpreted in the context of relevant scientific and clinical information.
Compound 528892: 5-Ethyl-5-(3-oxy-1-cyclohexenyl)-hexahydropyrimidin-2,4,6-trione

Chemical compound data from PubChem database. IUPAC Name: 5-ethyl-5-(3-oxocyclohexen-1-yl)-1,3-diazinane-2,4,6-trione. Molecular Formula: C12H14N2O4. Molecular Weight: 250.25. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
EHR Developers Reported by Health Care Providers Participating in Federal Programs

The Medicare &amp; Medicaid Electronic Health Record (EHR) Incentive Programs provide incentives to eligible ambulatory and inpatient providers to adopt electronic health records. This dataset provides the counts of health care providers that have reported a developer's product through participation in the Medicare EHR Incentive Program. The data are provided beginning in 2011. This dataset enables the tracking of trends in the adoption of healthIT by developer and by both office-based health care providers and non-federal acute-care hospitals. Filter the data by Program Year to get the most recent counts by health care provider type. The most recent data is available through the 2016 Program Year.
Dental Utilization Measures and Sealant Data by Age Groups Calendar Year 2013 to 2022

This dataset shows the use of Medi-Cal dental benefits by Medi-Cal members, displayed by age group and calendar year (for 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, and 2022). This information is displayed in the following categories: Annual Dental Visit, Exams/Oral Health Evaluations, Use of Diagnostic Services, Use of Dental Treatment Services, Use of Preventive Services, Use of Restorative Services, Treatment/Prevention for Caries, and Use of Sealants. The Medi-Cal members were continuously enrolled in either Dental Managed Care or the dental Fee-for-Service delivery system for the entire measurement period.
Correlation between graphitic carbon and elemental carbon in diesel particulate matter in workplace atmospheres-Dataset

We investigated the suitability of graphitic carbon (GC) content of diesel particulate matter (DPM), measured using Raman spectroscopy, as a surrogate measure of elemental carbon (EC), determined by thermal optical analysis.  Raman spectra in the range of 800-1800 cm-1 (including the D mode at ~1322 cm-1 and the G mode at ~1595 cm-1) were used for GC identification and quantification. Raman spectra for two certified DPM standards (SRM 1650 and SRM 2975), two types of diesel engine exhaust soot, and three types of DPM-enriched workplace aerosols were obtained.
Compound 526295: 1,4,8-Tribromo-dibenzofuran

Chemical compound data from PubChem database. IUPAC Name: 1,4,8-tribromodibenzofuran. Molecular Formula: C12H5Br3O. Molecular Weight: 404.88. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Table 3. 2011-2012 NSDUH Marijuana Use in the Past Month, by Age Group and State

Table 3. Marijuana Use in the Past Month, by Age Group and State: Percentages, Annual Averages Based on 2011 and 2012 NSDUHs. Results are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.
NNDSS - Table 1D. Arboviral diseases, Western equine encephalitis virus disease to Babesiosis

NNDSS - Table 1D. Arboviral diseases, Western equine encephalitis virus disease to Babesiosis - 2022. In this Table, provisional cases* of notifiable diseases are displayed for United States, U.S. territories, and Non-U.S. residents.

Notes:
•	These are weekly cases of selected infectious national notifiable diseases, from the National Notifiable Diseases Surveillance System (NNDSS). NNDSS data reported by the 50 states, New York City, the District of Columbia, and the U.S. territories are collated and published weekly as numbered tables available at https://www.cdc.gov/nndss/data-statistics/index.html. Cases reported by state health departments to CDC for weekly publication are subject to ongoing revision of information and delayed reporting. Therefore, numbers listed in later weeks may reflect changes made to these counts as additional information becomes available. Case counts in the tables are presented as published each week. See also Guide to Interpreting Provisional and Finalized NNDSS Data at https://www.cdc.gov/nndss/docs/Readers-Guide-WONDER-Tables-20210421-508.pdf.
• Notices, errata, and other notes are available in the Notice To Data Users page at https://wonder.cdc.gov/nndss/NTR.html.
•	The list of national notifiable infectious diseases and conditions and their national surveillance case definitions are available at https://ndc.services.cdc.gov/. This list incorporates the Council of State and Territorial Epidemiologists (CSTE) position statements approved by CSTE for national surveillance.
Footnotes:
*Case counts for reporting years 2021 and 2022 are provisional and subject to change. Cases are assigned to the reporting jurisdiction submitting the case to NNDSS, if the case's country of usual residence is the U.S., a U.S. territory, unknown, or null (i.e. country not reported); otherwise, the case is assigned to the 'Non-U.S. Residents' category. Country of usual residence is currently not reported by all jurisdictions or for all conditions. For further information on interpretation of these data, see https://www.cdc.gov/nndss/docs/Readers-Guide-WONDER-Tables-20210421-508.pdf.
†Previous 52 week maximum and cumulative YTD are determined from periods of time when the condition was reportable in the jurisdiction (i.e., may be less than 52 weeks of data or incomplete YTD data).
U: Unavailable — The reporting jurisdiction was unable to send the data to CDC or CDC was unable to process the data.
-: No reported cases — The reporting jurisdiction did not submit any cases to CDC.
N: Not reportable — The disease or condition was not reportable by law, statute, or regulation in the reporting jurisdiction.
NN: Not nationally notifiable — This condition was not designated as being nationally notifiable.
NP: Nationally notifiable but not published.
NC: Not calculated — There is insufficient data available to support the calculation of this statistic.
Cum: Cumulative year-to-date counts.
Max: Maximum — Maximum case count during the previous 52 weeks.
Compound 527041: N-cycloheptyl-N-methyl-benzamide

Chemical compound data from PubChem database. IUPAC Name: N-cycloheptyl-N-methylbenzamide. Molecular Formula: C15H21NO. Molecular Weight: 231.33. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
2010 State Profile — Virgin Islands

This state profile includes data from facilities in Virgin Islands that reported to N-SSATS for the survey reference date March 31, 2010. Data were collected on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse treatment facilities (both public and private) in Virgin Islands. In the Virgin Islands, 3 substance abuse treatment facilities were included in the 2010 N-SSATS, reporting that there were 105 clients in substance abuse treatment on March 31, 2010. The survey response rate in the Virgin Islands was 100.0%.
Compound 528145: 5-sec-butyl-2-Ethoxy-3-methylpyrazine

Chemical compound data from PubChem database. IUPAC Name: 5-butan-2-yl-2-ethoxy-3-methylpyrazine. Molecular Formula: C11H18N2O. Molecular Weight: 194.27. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 525686: p-Chlorobenzylidene-decyl-amine

Chemical compound data from PubChem database. IUPAC Name: 1-(4-chlorophenyl)-N-decylmethanimine. Molecular Formula: C17H26ClN. Molecular Weight: 279.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Risk for rheumatic disease in relation to ethnicity and admixture

Risk of systemic lupus erythematosus (SLE) is high in west Africans compared with Europeans, and risk of rheumatoid arthritis (RA) is high in Native Americans compared with Europeans. These differences are not accounted for by differences in allele or haplotype frequencies in the human leucocyte antigen (HLA) region or any other loci known to influence risk of rheumatic disease. Where there has been admixture between two or more ethnic groups that differ in risk of disease, studies of the relationship of disease risk to proportionate admixture can help to distinguish between genetic and environmental explanations for ethnic differences in disease risk and to map the genes underlying these differences.
Patent AT-E40006-T1: [Translated] PENETRATOR FOR A SAVINGS PROJECTILE AND METHOD FOR MAKING THE SAME.

The invention relates to a penetrator (1, 11) made of heavy metal, such as, for instance, tungsten heavy metal or depleted uranium, for driving-cage projectiles which have the penetrator led by the driving cage in the gun barrel. The driving cage (6, 12) detaches itself from the penetrator after the launch. The penetrator (1, 11) shows lower strength and higher ductility in the middle portion (d) of its length than in its head portion (c) and, in its tail portion, it shows higher strength and lower ductility than in its middle portion (d) and lower strength and higher ductility than in its head portion (c). This shall decrease the risk of fracture when striking an armour. The varying strength values in the head portion (c), in the middle portion (d) and in the tail portion (e) are obtained by cold-hammering under varying degrees of deformation, by sintering from various powder mixtures or by varying partial heat-treatment in the various portions (head portion c, middle portion d and tail portion e), and these measures can be applied individually or in combination. At least one pilot core (14, 15) which is only loosely connected to the penetrator (1, 11) can also be fitted to the head portion.
A new chemical formulation for control of dental unit water line contamination: An 'in vitro' and clinical 'study'

Background
          Water delivered by dental units during routine dental practice is highly contaminated. The aim of this study is to evaluate the efficacy of a new chemical solution flushed through Dental Unit Water Lines (DUWL) for the control of contamination inside dental units.
        
        
          Materials and methods
          Six old dental units equipped with a device designed to automatically flush disinfecting solutions through the water system (Castellini Autosteril) were selected. Water samples from DUWL effluents were collected in each dental unit for 10 randomly selected days, before and after a 5 minute DUWL disinfecting cycle with TetraAcetylEthileneDiamine (TAED) and persalt (Ster4spray produced by Farmec spa, and distributed by Castellini spa). Water samples were plated in R2A Agar and cultured at room temperature for 7 days, and the total number of heterotrophic microorganisms counted and expressed in Log10 CFU/mL A general linear model was fitted and multiple regression ANOVA for repeated measures was used for the statistical analysis.
        
        
          Results
          The mean contamination in DUWL effluent at baseline was 5.45 ± 0.35 CFU/mL (range 4.79 to 5.93 CFU/mL). When water samples were tested "in vitro" against the chemical, no growth of heterotrophic bacteria was detected after a 5 minute contact in any of the water samples tested. After undergoing a 5 minute disinfecting cycle with the chemical, DUWL mean contamination in water effluents was 2.01 ± 0.32 CFU/mL (range 1.30 to 2.74 CFU/mL) (significant difference with respect to baseline).
        
        
          Conclusions
          An inbetween patient disinfecting procedure consisting of flushing DUWL with TAED and persalt equivalent to 0.26% peracetic acid could be useful in routine dental practice for cross-contamination control.
Patent AT-E401770-T1: [Translated] HEAT DISSIPATION IMPROVEMENTS FOR ELECTRONIC ENCLOSURES

An electronics enclosure is provided. The enclosure includes a cylindrical body, one or more modular card cages adapted to receive one or more electronic circuit cards. The one or more modular card cages including an outer frame member in direct physical and thermal contact with an inner wall of the cylindrical body, an inner frame member, one or more support members coupled between the outer frame member and the inner frame member, and a plurality of electronic device retainers adapted to couple to the modular card cage and hold each of the one or more electronic circuit cards in direct physical and thermal contact with one of the one or more support members. The support members provide an isolated heat dissipation path for heat, produced by each of the one or more electronic circuit cards, to be removed from the enclosure.
Compound 526452: Hexyl heptafluorobutanoate

Chemical compound data from PubChem database. IUPAC Name: hexyl 2,2,3,3,4,4,4-heptafluorobutanoate. Molecular Formula: C10H13F7O2. Molecular Weight: 298.2. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 525335: 1-(6'-Oxoheptyl)-3,7-dimethylxanthine

Chemical compound data from PubChem database. IUPAC Name: 3,7-dimethyl-1-(6-oxoheptyl)purine-2,6-dione. Molecular Formula: C14H20N4O3. Molecular Weight: 292.33. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.