AndreaBozzo/ceres-open-data-index huggingface dataset:
Within the fold: assessing differential expression measures and reproducibility in microarray assays

Fold-change' cutoffs have been widely used in microarray assays to identify genes that are differentially expressed. More accurate measures are required to identify high-confidence sets of genes with biologically meaningful changes in transcription. A general procedure for analyzing cDNA microarray data is proposed and validated. It is shown that pooled reference samples should be based not only on the expression of individual genes in each cell line but also on the expression levels of genes within cell lines.
NSDUH 2017 Questionnaire Dwelling Unit-Level and Person Pair-Level Sampling Weight Calibration

NSDUH allows for estimating characteristics at the person level, pair level, and household or QDU level. This report describes the weight calibration methods used for the pair- and QDU-level respondents. As described in the person-level report, NSDUH is an annual survey of about 67,500 people selected from the civilian, noninstitutionalized population aged 12 or older from all 50 states and the District of Columbia. A coordinated sample design was developed for the 2014 through 2017 NSDUHs. The coordinated design facilitated 50 percent overlap in third-stage units (area segments) within each successive 2-year period from 2014 through 2017.
NNDSS - Table IV. Tuberculosis

NNDSS - Table IV. Tuberculosis - 2016.This Table includes total number of cases reported in the United States, by region and by states, in accordance with the current method of displaying MMWR data.  Data on United States will exclude counts from US territories.  Footnote: C.N.M.I.: Commonwealth of Northern Mariana Islands. U: Unavailable.    -: No reported cases.    N: Not reportable.    NN: Not Nationally Notifiable    Cum: Cumulative year-to-date counts.    Min: Minimum.    Max: Maximum. * Case counts for reporting year 2015 and 2016 are provisional and subject to change. For further information on interpretation of these data, see http://wwwn.cdc.gov/nndss/document/ProvisionalNationaNotifiableDiseasesSurveillanceData20100927.pdf Data for TB are displayed quarterly.
Compound 525279: N'-Cyclohexyl-N,N-dimethyl-acetamidine

Chemical compound data from PubChem database. IUPAC Name: N'-cyclohexyl-N,N-dimethylethanimidamide. Molecular Formula: C10H20N2. Molecular Weight: 168.28. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Arthritis Research: more than a journal		  (http://arthritis-research.com)

We are delighted to welcome you to the first printed issue ofArthritis Research, a publication that has already existed on the		  Internet for the last few months. This fact alone is an indication that we are		  beginning a new type of publication - one that will have the goal of serving		  the multidisciplinary research community looking at all aspects of arthritis		  and related autoimmune diseases.
T-cell-mediated control of autoimmunity

Inflammatory responses provoked by pathogens are antigen-specific in their induction but are nonspecific in their effects. Consequently, they are potentially damaging to the host that produces them. In addition, the immune system can respond specifically to self antigens, thereby giving rise to autoimmune diseases. A number of regulatory mechanisms have evolved to prevent such adverse effects. One of these has been shown to depend on a particular subset of CD4+ T cells that appears to have evolved specifically for this protective role. These cells are termed regulatory T cells. This review summarises what is known about them.
Compound 526960: meta,para'-alpha-Hydroxydinitrodiphenylacetic acid, methyl ester

Chemical compound data from PubChem database. IUPAC Name: methyl 2-hydroxy-2-(3-nitrophenyl)-2-(4-nitrophenyl)acetate. Molecular Formula: C15H12N2O7. Molecular Weight: 332.26. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Louisiana (LA)

This report uses 2008 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past year alcohol use disorder and illicit drug use disorder among persons aged 12 or older for Louisiana overall and for substate regions within Louisiana. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE).
Compound 529482: Baicalein, TMS

Chemical compound data from PubChem database. IUPAC Name: 2-phenyl-5,6,7-tris(trimethylsilyloxy)chromen-4-one. Molecular Formula: C24H34O5Si3. Molecular Weight: 486.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
2013 CMHS Uniform Reporting System (URS) Table for Wyoming

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for Wyoming for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
NNDSS - TABLE 1Z. Pertussis to Poliomyelitis, paralytic

NNDSS - TABLE 1Z. Pertussis to Poliomyelitis, paralytic - 2022. In this Table, provisional cases* of notifiable diseases are displayed for United States, U.S. territories, and Non-U.S. residents.

Notes:

•	These are weekly cases of selected infectious national notifiable diseases, from the National Notifiable Diseases Surveillance System (NNDSS). NNDSS data reported by the 50 states, New York City, the District of Columbia, and the U.S. territories are collated and published weekly as numbered tables available at https://www.cdc.gov/nndss/data-statistics/index.html. Cases reported by state health departments to CDC for weekly publication are subject to ongoing revision of information and delayed reporting. Therefore, numbers listed in later weeks may reflect changes made to these counts as additional information becomes available. Case counts in the tables are presented as published each week. See also Guide to Interpreting Provisional and Finalized NNDSS Data at https://www.cdc.gov/nndss/docs/Readers-Guide-WONDER-Tables-20210421-508.pdf.
• Notices, errata, and other notes are available in the Notice To Data Users page at https://wonder.cdc.gov/nndss/NTR.html.
•	The list of national notifiable infectious diseases and conditions and their national surveillance case definitions are available at https://ndc.services.cdc.gov/. This list incorporates the Council of State and Territorial Epidemiologists (CSTE) position statements approved by CSTE for national surveillance.

Footnotes:

*Case counts for reporting years 2021 and 2022 are provisional and subject to change. Cases are assigned to the reporting jurisdiction submitting the case to NNDSS, if the case's country of usual residence is the U.S., a U.S. territory, unknown, or null (i.e. country not reported); otherwise, the case is assigned to the 'Non-U.S. Residents' category. Country of usual residence is currently not reported by all jurisdictions or for all conditions. For further information on interpretation of these data, see https://www.cdc.gov/nndss/docs/Readers-Guide-WONDER-Tables-20210421-508.pdf.
†Previous 52 week maximum and cumulative YTD are determined from periods of time when the condition was reportable in the jurisdiction (i.e., may be less than 52 weeks of data or incomplete YTD data).
U: Unavailable — The reporting jurisdiction was unable to send the data to CDC or CDC was unable to process the data.
-: No reported cases — The reporting jurisdiction did not submit any cases to CDC.
N: Not reportable — The disease or condition was not reportable by law, statute, or regulation in the reporting jurisdiction.
NN: Not nationally notifiable — This condition was not designated as being nationally notifiable.
NP: Nationally notifiable but not published.
NC: Not calculated — There is insufficient data available to support the calculation of this statistic.
Cum: Cumulative year-to-date counts.
Max: Maximum — Maximum case count during the previous 52 weeks.
Rhode Island 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.
Compound 529012: Dimethyl-t-butylbenzene

Chemical compound data from PubChem database. IUPAC Name: 1-tert-butyl-2,3-dimethylbenzene. Molecular Formula: C12H18. Molecular Weight: 162.27. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E401637-T1: [Translated] MONITORING SYSTEM FOR DETERMINING POSITION IN A THREE-DIMENSIONAL SPACE

A surveillance system using an array of detectors onto which energy from the scene under surveillance is focused can indicate the direction of an event that has been recognised. The invention uses two or more arrays to locate events in three dimensions, and to define regions within the three dimensional space being surveyed. The events are located by detecting which elements from the respective arrays are stimulated by the occurrence of an event, and determining the location of the event to be at the intersection of the fields of view of the stimulated elements. <IMAGE>
Compound 526163: Diethyl 2,5-dichloro-phenyl phosphate

Chemical compound data from PubChem database. IUPAC Name: (2,5-dichlorophenyl) diethyl phosphate. Molecular Formula: C10H13Cl2O4P. Molecular Weight: 299.08. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 530774: 2-Chlorophenyl 4-methylbenzoate

Chemical compound data from PubChem database. IUPAC Name: (2-chlorophenyl) 4-methylbenzoate. Molecular Formula: C14H11ClO2. Molecular Weight: 246.69. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
The Adaptive Evolution Database (TAED)

Background
          The Master Catalog is a collection of evolutionary families, including multiple sequence alignments, phylogenetic trees and reconstructed ancestral sequences, for all protein-sequence modules encoded by genes in GenBank. It can therefore support large-scale genomic surveys, of which we present here The Adaptive Evolution Database (TAED). In TAED, potential examples of positive adaptation are identified by high values for the normalized ratio of nonsynonymous to synonymous nucleotide substitution rates (KA/KS values) on branches of an evolutionary tree between nodes representing reconstructed ancestral sequences.
        
        
          Results
          Evolutionary trees and reconstructed ancestral sequences were extracted from the Master Catalog for every subtree containing proteins from the Chordata only or the Embryophyta only. Branches with high KA/KS values were identified. These represent candidate episodes in the history of the protein family when the protein may have undergone positive selection, where the mutant form conferred more fitness than the ancestral form. Such episodes are frequently associated with change in function. An unexpectedly large number of families (between 10% and 20% of those families examined) were found to have at least one branch with high KA/KS values above arbitrarily chosen cut-offs (1 and 0.6). Most of these survived a robustness test and were collected into TAED.
        
        
          Conclusions
          TAED is a raw resource for bioinformaticists interested in data mining and for experimental evolutionists seeking candidate examples of adaptive evolution for further experimental study. It can be expanded to include other evolutionary information (for example changes in gene regulation or splicing) placed in a phylogenetic perspective.
Localization of heat shock protein 20 in swine carotid artery

Background
          Cyclic nucleotides can relax vascular smooth muscle by mechanisms distal to myosin regulatory light chain (MRLC) phosphorylation. This mechanism, termed relaxation without MRLC dephosphorylation, may be regulated by ser16 phosphorylation of heat shock protein 20 (HSP20).
        
        
          Results
          Confocal imaging of HSP20 in smooth muscle tissues revealed that HSP20 was present throughout the cytoplasm, although some focal regions of the cytoplasm were found to contain more HSP20 than the remaining cytoplasm. The distribution of HSP20 within the cytoplasm was not altered by histamine, forskolin, or nitroglycerin.
        
        
          Conclusion
          Cytoplasmic localization of HSP20 is consistent with a potential function of HSP20 as a regulator of smooth muscle contractile force.
Compound 525637: N,N-Dimethyl-N'-nonyl-p-methylbenzamidine

Chemical compound data from PubChem database. IUPAC Name: N,N,4-trimethyl-N'-nonylbenzenecarboximidamide. Molecular Formula: C19H32N2. Molecular Weight: 288.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
4.9 Services provided, by primary focus of facility: 2011. Number and percent

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing services provided, by primary focus of facility in 2011. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.
Compound 530472: m-Toluic acid, 2-adamantyl ester

Chemical compound data from PubChem database. IUPAC Name: 2-adamantyl 3-methylbenzoate. Molecular Formula: C18H22O2. Molecular Weight: 270.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Crystal structure of LIR-2 (ILT4) at 1.8 Å: differences from LIR-1 (ILT2) in regions implicated in the binding of the Human Cytomegalovirus class I MHC homolog UL18

Background
          Leukocyte Immunoglobulin-like Receptor-1 (LIR-1) and LIR-2 (also known as ILT2 and ILT4 respectively) are highly related cell surface receptors that bind a broad range of class I MHC molecules with low (μM) affinities. Expressed on monocytic cells and macrophages, both molecules transmit inhibitory signals after binding ligands. In addition to binding host class I MHC, the LIR-1 molecule, which is also expressed on lymphoid tissues, binds with a high (nM) affinity to UL18, a class I MHC homolog encoded by Human Cytomegalovirus (HCMV). In comparison, LIR-2 binds UL18 only weakly (μM KD). To understand how HCMV preferentially targets the more broadly expressed LIR-1 molecule, we determined the crystal structure of a ligand-binding fragment of LIR-2, and compared this to the existing high-resolution crystal structure of LIR-1.
        
        
          Results
          Recombinant LIR-2 (domains 1 and 2) was produced in E. coli and crystallized using streak seeding to optimize the crystal morphology. A data set complete to 1.8 Å was collected at 100 K from a single crystal in the P41212 spacegroup. The structure was solved by molecular replacement, using a search model based on the LIR-1 structure.
        
        
          Conclusions
          The overall structure of LIR-2 D1D2 resembles both LIR-1, and Killer Inhibitory Receptors, in that the A strand in each domain forms hydrogen bonds to both β sheets, and there is a sharp angle between the two immunoglobulin-like domains. However, differences from LIR-1 are observed in each domain, with two key changes apparent in the ligand-binding domain, D1. The region corresponding to the residue 44–57 helix of LIR-1 adopts a topology distinct from that of both LIR-1 and the KIR structures, involving a shortened 310 helix. Secondly, the predicted UL18 binding region of LIR-1 is altered substantially in LIR-2: the 76–84 loop mainchain is displaced 11 Å with respect to LIR-1, and Tyrosine 38 adopts an alternative rotamer conformation. In summary, the structure of LIR-2 has revealed significant differences to LIR-1, including ones that may help to explain the >1000-fold lower affinity of LIR-2 for UL18.
Patent AT-E399539-T1: [Translated] TWO-PHASE RELEASE FORMULATION CONTAINING HISTONE DEACETYLASE INHIBITOR

The present invention relates to an orally available galenics formulation of Valproic Acid or derivatives thereof exhibiting a specific bi-phasic pharmacokinetic profile optimized for maximum inhibition of histone deacetylases in a therapeutic setting. This specific galenics formulation is designed for the treatment of malignant diseases and diseases associated with hypoacetylation of histones or in which induction of hyperacetylation has a beneficial effect, e.g., by induction of differentiation and/or apoptosis. Due to the bi-phasic release pattern the resulting pharmacokinetic profile is able to inhibit HDAC target enzymes most efficiently and to subsequently induce histone hyperacetylation in a rapid as well as a long-lasting fashion. This profile secures the efficient modulation of a desired target gene expression profile which contributes to the therapeutic benefit.
Compound 525345: 2-(tert-Butyldisulfanyl)butane

Chemical compound data from PubChem database. IUPAC Name: 2-(tert-butyldisulfanyl)butane. Molecular Formula: C8H18S2. Molecular Weight: 178.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E400231-T1: [Translated] CATHETER WITH DIRECTORABLE TIP AND GUIDE WIRE TRACKING MECHANISM

A deflectable tip catheter that is used in combination with a guidewire for delivery of an ablation element to target areas of a patient's vasculature. The deflectable tip catheter has a handle portion, an elongated shaft and a deflectable tip portion. A guidewire lumen extends through the elongated shaft and deflectable tip portion. A guidewire passes through the guidewire lumen and exits from a port in the distal end of the deflectable tip portion. The deflectable tip of the catheter is deflected by manipulation of the handle portion to direct the advancement of the guidewire as the guidewire is advanced out of the distal port. By using the deflectable tip portion to direct the advancement of the guidewire, the physician's ability to navigate sharp angles is greatly improved. The deflectable tip catheter is particularly suitable for delivering an ablation element to a pulmonary vein or pulmonary vein branch for performing circumferential ultrasound vein ablation to treat atrial fibrillation.
Patent AT-E401156-T1: [Translated] CUTTING TOOL ASSEMBLY

The present invention provides a cutting tool assembly having a tool shank with an elongated hole extending axially through the tool shank. An elongated support bar having threaded bore at its forward end is retained in the elongated hole. A cutting head having a forward cutting portion and a rear threaded portion is retained in the support bar with its rear threaded portion threadingly engaged with the threaded bore in the forward end of the support bar.
Attitudes of Mexican anesthesiologists to indicate preoperative fasting periods: A cross-sectional survey

Background
          In Mexico, guidelines for fasting periods, or any audits on this topic are unavailable, and therefore the attitudes of anesthesiologists for recommending preoperative fasting periods are unknown.
        
        
          Material and methods
          The study was a cross-sectional survey of anesthesiologists subscribed to the Annual Updated Course, organized by the Sociedad Mexicana de Anestesiologia in 2000. The response rate was 31.4%.
        
        
          Results
          Most respondents were general anesthesiologists, with 5 or more years experience in a clinical post, were working in both public and private hospitals, and were performing anesthetic procedures on both pediatric and adult patients and in both ambulatory and hospitalized patients. Approximately 23% of the respondents considered natural fruit juices to be clear liquids. For a pediatric patient ingesting breast milk 1 h before undergoing a surgical procedure, 45% thought that surgery should be delayed for 3h, followed by those delaying the surgical procedure for 6 to 8 h. Our results show that more than 50% of the anesthesiologists had better defined attitudes for fasting milk and clear liquids in patients of 6 month or under than for older children and adults. However, due to the poor definition or pre-operative fasting, using clear liquids, in all other patient groups, several patients are allowed to go without oral clear liquids administration for prolonged periods.
        
        
          Conclusion
          Preoperative fasting periods recommended by Mexican anesthesiologists differ from international guidelines.