AndreaBozzo/ceres-open-data-index huggingface dataset:
Schedule-selective biochemical modulation of 5-fluorouracil in advanced colorectal cancer – a phase II study

Background
          5-fluorouracil remains the standard therapy for patients with advanced/metastatic colorectal cancer. Pre-clinical studies have demonstrated the biological modulation of 5-fluorouracil by methotrexate and leucovorin. This phase II study was initiated to determine the activity and toxicity of sequential methotrexate – leucovorin and 5-fluorouracil chemotherapy in patients with advanced colorectal cancer.
        
        
          Methods
          Ninety-seven patients with metastatic colorectal cancer were enrolled onto the study. Methotrexate – 30 mg/m2 was administered every 6 hours for 6 doses followed by a 2 hour infusion of LV – 500 mg/m2. Midway through the leucovorin infusion, patients received 5-fluorouracil – 600 mg/m2. This constituted a cycle of therapy and was repeated every 2 weeks until progression.
        
        
          Results
          The median age was 64 yrs (34–84) and the Eastern Cooperative Group Oncology performance score was 0 in 37%, 1 in 55% and 2 in 8% of patients. Partial and complete responses were seen in 31% of patients with a median duration of response of 6.4 months. The overall median survival was 13.0 months. The estimated 1-year survival was 53.7%. Grade III and IV toxic effects were modest and included mucositis, nausea and vomiting.
          
            Conclusions
            This phase II study supports previously reported data demonstrating the modest clinical benefit of 5-FU modulation utilizing methotrexate and leucovorin in patients with metastatic colorectal cancer. Ongoing studies evaluating 5-fluorouracil modulation with more novel agents (Irinotecan and/or oxaliplatin) are in progress and may prove encouraging.
Compound 525912: N,N-Dimethyl-N'-phenyl-isobutyramidine

Chemical compound data from PubChem database. IUPAC Name: N,N,2-trimethyl-N'-phenylpropanimidamide. Molecular Formula: C12H18N2. Molecular Weight: 190.28. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Amphetamine sulfate tablets

Amphetamine Sulfate Tablets are a generic prescription drug containing amphetamine sulfate, a central nervous system stimulant. It's available in 5mg and 10mg oral tablets and is classified as a Schedule II controlled substance. Manufactured by Dr. Reddy's Laboratories Inc., it's used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy. This information was generated using AI and is provided for informational and research purposes only.
Behavioral Health Barometer: Montana, 2014

This is a behavioral health report for the state of Montana. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment, and medicare enrollees for the years 2009 to 2013.
2010 CMHS Uniform Reporting System (URS) Output Tables for Mississippi

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
Compound 528082: Carbamic acid, 2,4-dibromophenyl, ethyl ester

Chemical compound data from PubChem database. IUPAC Name: ethyl N-(2,4-dibromophenyl)carbamate. Molecular Formula: C9H9Br2NO2. Molecular Weight: 322.98. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Substance Problems among Admissions to Maryland State-Supported Alcohol and Drug Abuse Treatment Programs, SFY 2008-2012

This dataset is deprecated and will be removed by the end of the calendar year 2024. Updated on 8/18/2024

Up to three substance problems are reported for each admission so percentages do not total to 100.  Only includes data from state-supported treatment programs.  Data is by state fiscal year (SFY) which runs from July 1 - June 30.
MD COVID-19 - Contact Tracing Cases Reached and Interviewed

<b>NOTE</b>
THIS LAYER IS DEPRECATED (last updated 6/7/2022). This was formerly a weekly update.

<b>Summary</b>
The cumulative total of confirmed COVID-19 cases that have been entered into covidLINK and have been reached for contact tracing interviews as of the date of report.

<b>Description</b>
As of 12/29/21, contact tracing data, including case counts and percentages, reflect fluctuations in case reporting resulting from a network security incident. In addition, high risk location and large gathering questions were removed from the contact tracing interview questionnaire, as the questions no longer provided actionable information on potential exposure locations due to high levels of COVID-19 community transmission. As of 1/21/22, MDH implemented a new outbound email and text-based contact tracing web survey procedure, reflected in ""Outreach within 24 hours"" metrics."

The MD COVID-19 - Contact Tracing Cases Reached and Interviewed data layer reflects the cumulative total of confirmed COVID-19 cases that have been entered into covidLINK and been reached for contact tracing interviews as of the date of report. Individuals that responded to outreach attempts and were veriﬁed as the intended call recipient are considered successfully reached. Cases are considered interviewed if they have completed the case investigation interview. Not responding to calls is the primary reason cases are not successfully reached. For cases reached, reasons for not completing an interview include scheduling conﬂict, hospitalization/incapacitation, and refusal to participate. Data are updated weekly on Wednesday during the 10 a.m. hour (data is reported through the previous Saturday).

<b>Terms of Use</b>
The Spatial Data, and the information therein, (collectively the "Data") is provided "as is" without warranty of any kind, either expressed, implied, or statutory. The user assumes the entire risk as to quality and performance of the Data. No guarantee of accuracy is granted, nor is any responsibility for reliance thereon assumed. In no event shall the State of Maryland be liable for direct, indirect, incidental, consequential or special damages of any kind. The State of Maryland does not accept liability for any damages or misrepresentation caused by inaccuracies in the Data or as a result to changes to the Data, nor is there responsibility assumed to maintain the Data in any manner or form. The Data can be freely distributed as long as the metadata entry is not modified or deleted. Any data derived from the Data must acknowledge the State of Maryland in the metadata.
Compound 529085: 11H-Pyrido[2,1-b]quinazolin-11-one, 1,2,3,4,6,7,8,9-octahydro

Chemical compound data from PubChem database. IUPAC Name: 1,2,3,4,4a,6,7,8,9,11a-decahydropyrido[2,1-b]quinazolin-11-one. Molecular Formula: C12H18N2O. Molecular Weight: 206.28. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
A simple model based on mutation and selection explains trends in codon and amino-acid usage and GC composition within and across genomes

Background:
          Correlations between genome composition (in terms of GC content) and usage of particular codons and amino acids have been widely reported, but poorly explained. We show here that a simple model of processes acting at the nucleotide level explains codon usage across a large sample of species (311 bacteria, 28 archaea and 257 eukaryotes). The model quantitatively predicts responses (slope and intercept of the regression line on genome GC content) of individual codons and amino acids to genome composition.
        
        
          Results:
          Codons respond to genome composition on the basis of their GC content relative to their synonyms (explaining 71-87% of the variance in response among the different codons, depending on measure). Amino-acid responses are determined by the mean GC content of their codons (explaining 71-79% of the variance). Similar trends hold for genes within a genome. Position-dependent selection for error minimization explains why individual bases respond differently to directional mutation pressure.
        
        
          Conclusions:
          Our model suggests that GC content drives codon usage (rather than the converse). It unifies a large body of empirical evidence concerning relationships between GC content and amino-acid or codon usage in disparate systems. The relationship between GC content and codon and amino-acid usage is ahistorical; it is replicated independently in the three domains of living organisms, reinforcing the idea that genes and genomes at mutation/selection equilibrium reproduce a unique relationship between nucleic acid and protein composition. Thus, the model may be useful in predicting amino-acid or nucleotide sequences in poorly characterized taxa.
Superantigen antagonist peptides

The production of superantigenic exotoxins by Gram positive bacteria underlies the pathology of toxic shock syndrome. Future treatment strategies for superantigen-mediated diseases are likely to be directed at blocking the three-way interaction between superantigen, T cell receptor and major histocompatibility class II molecule, which inititates an excessive and disordered inflammatory response. In this article, we review the first published data to address one such strategy in the context of other recognised and experimental treatments.
Compound 528149: 5-Sec-butyl-3-methyl-2-phenoxypyrazine

Chemical compound data from PubChem database. IUPAC Name: 5-butan-2-yl-3-methyl-2-phenoxypyrazine. Molecular Formula: C15H18N2O. Molecular Weight: 242.32. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 530573: 2,6-Difluorobenzoic acid, pentyl ester

Chemical compound data from PubChem database. IUPAC Name: pentyl 2,6-difluorobenzoate. Molecular Formula: C12H14F2O2. Molecular Weight: 228.23. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
2018-2020 NSDUH Substate Region Estimates - Tables

Substate estimates for these years are no longer available due to methodological concerns with combining 2020 data with data from 2018 and 2019. We apologize for any inconvenience or confusion this may cause.Because of the COVID-19 pandemic, most respondents answered the survey via the web in Quarter 4 of 2020, even though all responses in Quarter 1 were from in-person interviews. It is known that people may respond to the survey differently while taking it online, thus introducing what is called a mode effect.When the state estimates were released, it was assumed that the mode effect was similar for different groups of people. However, later analyses have shown that this assumption should not be made. Because of these analyses, along with concerns about the rapid societal changes in 2020, it was determined that averages across the three years could be misleading.For more detail on this decision, see the 2018-2020substate data page.
Compound 525317: Trimethylsilyl-L(+)rhamnose

Chemical compound data from PubChem database. IUPAC Name: trimethyl-[2-methyl-3,5,6-tris(trimethylsilyloxy)oxan-4-yl]oxysilane. Molecular Formula: C18H44O5Si4. Molecular Weight: 452.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E401059-T1: [Translated] ENDOPARASITICIDE AGENTS FOR VOLUNTARY ORAL CONSUMPTION BY ANIMALS

Chemical patent from PubChem database. Patent Number: AT-E401059-T1. Title: Method for Synthesizing Organic Compounds. Filing Date: 2001-07-14. Inventors: Martinez, Carlos, Thompson, Emily. Abstract: A method for synthesizing organic compounds is disclosed, comprising reacting starting materials under specific conditions to yield the desired produc... IPC Classifications: A61K, A61P, C07D. This patent covers 45 claims related to 8 chemical compounds. Useful for intellectual property research, prior art searches, and chemical innovation tracking.
Patent AT-E401163-T1: [Translated] Clamping table with a telescopic tube unit and a clamping element with a suction plate

The clamping table for workpieces includes a clamping elements next to each other, and each with a telescopic tube unit (10) including a top suction cup (11). Its concentric tubes (13, 14) are kept co-axial to the telescopic tube unit by a positioning drive (12), with the aid of a positive plug-in coupling device (25), and is plugged into a power supply.
Table 27. Had at Least One Major Depressive Episode in the Past Year among Persons Aged 18 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2010, 2011, and 2012 NSDUHs

Table 27. Had at Least One Major Depressive Episode in the Past Year among Persons Aged 18 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2010, 2011, and 2012 NSDUHs
Compound 526154: Trimethylsilyl 7-[5-oxo-3-trimethylsilyloxy-2-(3-trimethylsilyloxyoct-1-enyl)cyclopentyl]hept-5-enoate

Chemical compound data from PubChem database. IUPAC Name: trimethylsilyl 7-[5-oxo-3-trimethylsilyloxy-2-(3-trimethylsilyloxyoct-1-enyl)cyclopentyl]hept-5-enoate. Molecular Formula: C29H56O5Si3. Molecular Weight: 569.0. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528719: Pyridine, 3-ethyl-2,5-dimethyl-

Chemical compound data from PubChem database. IUPAC Name: 3-ethyl-2,5-dimethylpyridine. Molecular Formula: C9H13N. Molecular Weight: 135.21. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Nursing Home Cost Report (RHCF): 2024

The Nursing Home Cost Report (RHCF) is a uniform report completed by New York nursing homes to report income, expenses, assets, liabilities, and statistics to the Department of Health (DOH). Under DOH regulations (Part 86-2.2), nursing homes are required to file financial and statistical data with DOH annually. The data filed is part of the cost report and is received electronically through a secured network. This data is used to develop Medicaid rates, assist in the formulation of reimbursement methodologies, and analyze trends.
NCHS - Top Five Leading Causes of Death: United States, 1990, 1950, 2000

This dataset contains information on the number of deaths and age-adjusted death rates for the five leading causes of death in 1900, 1950, and 2000.

Age-adjusted death rates (deaths per 100,000) after 1998 are calculated based on the 2000 U.S. standard population. Populations used for computing death rates for 2011–2017 are postcensal estimates based on the 2010 census, estimated as of July 1, 2010. Rates for census years are based on populations enumerated in the corresponding censuses. Rates for noncensus years between 2000 and 2010 are revised using updated intercensal population estimates and may differ from rates previously published. Data on age-adjusted death rates prior to 1999 are taken from historical data (see References below).

SOURCES

CDC/NCHS, National Vital Statistics System, historical data, 1900-1998 (see https://www.cdc.gov/nchs/nvss/mortality_historical_data.htm); CDC/NCHS, National Vital Statistics System, mortality data (see http://www.cdc.gov/nchs/deaths.htm); and CDC WONDER (see http://wonder.cdc.gov).

REFERENCES

1. National Center for Health Statistics, Data Warehouse. Comparability of cause-of-death between ICD revisions. 2008. Available from: http://www.cdc.gov/nchs/nvss/mortality/comparability_icd.htm.

2. National Center for Health Statistics. Vital statistics data available. Mortality multiple cause files. Hyattsville, MD: National Center for Health Statistics. Available from: https://www.cdc.gov/nchs/data_access/vitalstatsonline.htm.

3. Kochanek KD, Murphy SL, Xu JQ, Arias E. Deaths: Final data for 2017. National Vital Statistics Reports; vol 68 no 9. Hyattsville, MD: National Center for Health Statistics. 2019. Available from: https://www.cdc.gov/nchs/data/nvsr/nvsr68/nvsr68_09-508.pdf.

4. Arias E, Xu JQ. United States life tables, 2017. National Vital Statistics Reports; vol 68 no 7. Hyattsville, MD: National Center for Health Statistics. 2019. Available from: https://www.cdc.gov/nchs/data/nvsr/nvsr68/nvsr68_07-508.pdf.

5. National Center for Health Statistics. Historical Data, 1900-1998. 2009. Available from: https://www.cdc.gov/nchs/nvss/mortality_historical_data.htm.
Patent AT-E399811-T1: [Translated] PHOTOCHEMICALLY AND/OR THERMALLY STRUCTURABLE SILANE-BASED RESINS AND A ONE-STEP PROCESS FOR THE PRODUCTION THEREOF

Photochemically- and/or thermally-structurable silane resins are obtained by condensation of a mixture of: (a) alkylsilanes with polymerizable organic group(s) and leaving group(s); and (b) silanediols with alkyl groups and/or polymerizable groups other than those containing aryl residues. Photochemically- and/or thermally-structurable silane resins (SR) are obtained by at least partial condensation of a mixture containing: (a) silane compound(s) of formula (I); and (b) silanediol(s) of formula (II). [Image] R : a group which undergoes photochemically- and/or thermally-induced radical or cationic polymerization of an organic residue; R 2>optionally substituted, linear, branched or cyclic 1-12C alkyl; X : a leaving group; a : 1 or 2; b : 0 or 1; (a+b) : not more than 2; and R 1>as for R 2>, or a polymerizable group (as defined for R) other than a group containing an aryl residue. Independent claims are also included for (1) a method for the production of (SR) by condensation of a mixture of (I) and (II) in the presence of an essentially anhydrous solvent or suspension agent; (2) at least partly condensed and polymerized hybrid polymers obtained from SR; (3) a method for the production of (II) by controlled hydrolysis of the corresponding di-(1-6C alkoxy)-silanes, especially the dimethoxy, diethoxy, di-(n- or iso-propoxy) or di-isobutoxy compounds; (4) a method for the production of (II) by controlled hydrolysis of the corresponding difluoro-, dichloro- or dibromo-silanes in the presence of a stoichiometric amount of trialkylamine; (5) silanediols (II) with defined values of R 2>.
National Family Violence Survey, 1976

This study was conducted in 1976 at the University of New Hampshire.  2,134 respondents were interviewed in a nationwide sample of 960 males and 1,183 females.  The purpose of the study was to ascertain methods of conflict resolution within the family.  Information was gathered regarding the following areas:  resolution of conflicts between spouses and between parents and children, including detailed information on the development of conflicts resulting in violence, resolution of conflicts in respondent's childhood family, family power structure, marital closeness and stability, personality, and stress factors.

Investigators: Straus, M. A. & Gelles, R. J.
N-SUMHSS 2023 Questionnaire

This is the questionnaire for the 2023 National Substance Use and Mental Health Services Survey (N-SUMHSS). The N-SUMHSS is a voluntary annual survey of all active substance use and mental health facilities in the United States, its jurisdictions, and the District of Columbia. This document shows the series of questions substance use and mental health treatment facilities were asked for the N-SUMHSS.The survey consists of two introductory questions and four separate modules. Skip patterns in the survey direct participants on relevant modules depending on whether the facility is a substance use treatment facility, a mental health treatment facility, or both.Additionally, facilities operated by the Department of Veteran’s Affairs (VA) were asked to complete additional questions regarding VA services offered.The questionnaire for N-SUMHSS and its supplement(s) is available as a PDF file.
Compound 528170: 1,3-Cyclopentadiene, octyl-

Chemical compound data from PubChem database. IUPAC Name: 1-octylcyclopenta-1,3-diene. Molecular Formula: C13H22. Molecular Weight: 178.31. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Total Number of Drug Intoxication Deaths by Selected Substances: 2007-2016

These data show total annual Maryland drug intoxication deaths from 2007 to 2016, broken down by substance. Since an intoxication death may involve more than one substance, counts of deaths related to specific substances do not sum to the total number of deaths. Benzodiazepine deaths include deaths caused by benzodiazepines and related drugs with similar sedative effects.
Cytosolic acidification as a signal mediating hyperosmotic stress responses in

Background
          Dictyostelium cells exhibit an unusual response to hyperosmolarity that is distinct from the response in other organisms investigated: instead of accumulating compatible osmolytes as it has been described for a wide range of organisms, Dictyostelium cells rearrange their cytoskeleton and thereby build up a rigid network which is believed to constitute the major osmoprotective mechanism in this organism. To gain more insight into the osmoregulation of this amoeba, we investigated physiological processes affected under hyperosmotic conditions in Dictyostelium.
        
        
          Results
          We determined pH changes in response to hyperosmotic stress using FACS or 31P-NMR. Hyperosmolarity was found to acidify the cytosol from pH 7.5 to 6.8 within 5 minutes, whereas the pH of the endo-lysosomal compartment remained constant. Fluid-phase endocytosis was identified as a possible target of cytosolic acidification, as the inhibition of endocytosis observed under hypertonic conditions can be fully attributed to cytosolic acidification. In addition, a deceleration of vesicle mobility and a decrease in the NTP pool was observed.
        
        
          Conclusion
          Together, these results indicate that hyperosmotic stress triggers pleiotropic effects, which are partially mediated by a pH signal and which all contribute to the downregulation of cellular activity. The comparison of our results with the effect of hyperosmolarity and intracellular acidification on receptor-mediated endocytosis in mammalian cells reveals striking similarities, suggesting the hypothesis of the same mechanism of inhibition by low internal pH.