AndreaBozzo/ceres-open-data-index huggingface dataset:
B cells in rheumatoid arthritis

Normally the immune response is restricted to the peripheral secondary lymphoid organs. However, additional ectopic lymphoid tissue may develop at chronic sites of inflammation. In the synovium of rheumatoid arthritis patients the local production of proinflammatory cytokines seems to support the formation of a precisely structured microenvironment, which allows an antigen dependent immune response to take place. The analysis of the V-gene repertoire expressed in synovial B cells demonstrated that in the inflamed synovium a germinal centre reaction takes place. Antigen presented by a network of follicular dendritic cells may activate synovial B cells and support their differentiation into plasma cells secreting high affinity antibodies. The specificity of these antibodies remains to be determined.
2010 CMHS Uniform Reporting System (URS) Output Tables for Nevada

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
CDC STATE System E-Cigarette Legislation - Smokefree Campus

1995-2024. Centers for Disease Control and Prevention (CDC). State Tobacco Activities Tracking and Evaluation (STATE) System.  E-Cigarette Legislation—Smokefree Campus. The STATE System houses current and historical state-level legislative data on tobacco use prevention and control policies. Data are reported on a quarterly basis. Data include state smokefree indoor air laws for smokefree campuses in private and public colleges and schools (K-12).
Atezolizumab

Tecentriq (atezolizumab) is a prescription monoclonal antibody made by Genentech, Inc., given intravenously to treat certain cancers. It works by blocking PD-1 receptors to help the immune system fight tumors. Available as a 1200 mg/20 mL solution in single-use vials. This information was generated using AI and is provided for informational and research purposes only.
Bendamustine hydrochloride

Bendeka is a prescription intravenous chemotherapy drug containing bendamustine hydrochloride, an alkylating agent used to treat certain blood cancers like chronic lymphocytic leukemia and non-Hodgkin lymphoma. It comes as a 25 mg/mL solution in multi-dose vials, manufactured by Teva Pharmaceuticals USA, Inc. This information was generated using AI and is provided for informational and research purposes only.
Washington (WA)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Washington for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.
Patent AT-E400233-T1: [Translated] DENTAL IMPLANT WITH TWO IMPLANT PARTS

In a tooth implant for mounting onto an implant base carrier ( 2 ), including a support post and a crown releasably disposed on the support post, wherein the support post has a cone-shaped base body with at least a friction cone sector and an accommodation sector which, with respect to a rotationally symmetrical enveloping area as defined by the cone sector, forms a cavity under the crown upper and lower edge areas where the crown is in contact with the base body, the friction cone sector and a connecting line extending between upper and lower edge areas of the accommodation sector have, in a plane receiving the longitudinal axis of the support post, different inclination angles with respect to the longitudinal axis of the support post.
Kansas Intensive Permanency Project (KIPP) Program Manual

This PII grantee program manual provides detailed information about the implementation process of the Kansas Intensive Permanency Project (KIPP) to assist others in the field in replicating or adapting KIPP for their local use. Readers will find reflections, lessons learned, and other practical information based on the experience of the KIPP project. The manual can be especially helpful if you are considering implementation of the intervention, interested in addressing the needs of similar target populations, or interested in lessons learned from real-world implementation experiences. Together, the PII program manuals help to build a base of replicable interventions that can serve the complex needs of diverse communities of children and families.

Metadata-only record linking to the original dataset. Open original dataset below.
Retroviral transfer of the p16INK4a cDNA inhibits C6 glioma formation in Wistar rats

Background
          The p16INK4A gene product halts cell proliferation by preventing phosphorylation of the Rb protein. The p16INK4a gene is often deleted in human glioblastoma multiforme, contributing to unchecked Rb phosphorylation and rapid cell division. We show here that transduction of the human p16INK4a cDNA using the pCL retroviral system is an efficient means of stopping the proliferation of the rat-derrived glioma cell line, C6, both in tissue culture and in an animal model. C6 cells were transduced with pCL retrovirus encoding the p16INK4a, p53, or Rb genes. These cells were analyzed by a colony formation assay. Expression of p16INK4a was confirmed by immunohistochemistry and Western blot analysis. The altered morphology of the p16-expressing cells was further characterized by the senescence-associated β-galactosidase assay. C6 cells infected ex vivo were implanted by stereotaxic injection in order to assess tumor formation.
        
        
          Results
          The p16INK4a gene arrested C6 cells more efficiently than either p53 or Rb. Continued studies with the p16INK4a gene revealed that a large portion of infected cells expressed the p16INK4a protein and the morphology of these cells was altered. The enlarged, flat, and bi-polar shape indicated a senescence-like state, confirmed by the senescence-associated β-galactosidase assay. The animal model revealed that cells infected with the pCLp16 virus did not form tumors.
        
        
          Conclusion
          Our results show that retrovirus mediated transfer of p16INK4a halts glioma formation in a rat model. These results corroborate the idea that retrovirus-mediated transfer of the p16INK4a gene may be an effective means to arrest human glioma and glioblastoma.
Patent AT-E400923-T1: [Translated] ELECTRONIC PULSE GENERATOR AND OSCILLATOR

Improvements in and relating to electronic pulse generation or oscillation circuitry based on a signal path exhibiting endless electromagnetic continuity and affording signal phase inversion in setting pulse duration or half-cycles of oscillation within time of signal traverse of said signal path, and having active switching means associated with said signal path to set rise and fall times of each said pulse or said half-cycle of oscillation, including for frequency adjustment by selective inductance and power saving without stopping pulse generation or oscillation.
Table 13. Binge Alcohol Use in the Past Month among Persons Aged 12 to 20, by State and Substate Regions: Percentages, Annual Averages Based on 2008, 2009, and 2010 NSDUHs

This table presents the 2008 to 2010 National Survey on Drug Use and Health (NSDUH) estimates of past month binge alcohol use by those aged 12 to 20 in State and substate regions.
Compound 526613: 3,6-Dimethyl-1,2,4,5-tetrathiane

Chemical compound data from PubChem database. IUPAC Name: 3,6-dimethyl-1,2,4,5-tetrathiane. Molecular Formula: C4H8S4. Molecular Weight: 184.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Multi-Walled Carbon Nanotubes Induce Arachidonate 5-Lipoxygenase Expression and Enhance the Polarization and Function of M1 Macrophages in vitro

Fibrogenic carbon nanotubes (CNTs) induce the polarization of M1 and M2 macrophages in mouse lungs. Polarization of the macrophages regulates the production of proinflammatory and pro-resolving lipid mediators (LMs) to mediate acute inflammation and its resolution in a time-dependent manner. Here we examined the molecular mechanism by which multi-walled CNTs (MWCNTs, Mitsui-7) induce M1 polarization in vitro. Treatment of murine macrophages (J774A.1) with Mitsui-7 MWCNTs increased the expression of Alox5 mRNA and protein in a concentration- and time-dependent manner. The MWCNTs induced the expression of CD68, and that induction persisted for up to 3 days post-exposure. The expression and activity of inducible nitric oxide synthase, an intracellular marker of M1, were increased by MWCNTs. Consistent with M1 polarization, the MWCNTs induced the production and secretion of proinflammatory cytokines tumor necrosis factor-α and interleukin-1β, and proinflammatory LMs leukotriene B4 (LTB4) and prostaglandin E2 (PGE2). The cell-free media from MWCNT-polarized macrophages induced the migration of neutrophilic cells (differentiated from HL-60), which was blocked by Acebilustat, a specific leukotriene A4 hydrolase inhibitor, or LY239111, an LTB4 receptor antagonist, but not NS-398, a cyclooxygenase 2 inhibitor, revealing LTB4 as a major mediator of neutrophil chemotaxis from MWCNT-polarized macrophages. Knockdown of Alox5 using specific small hairpin-RNA suppressed MWCNT-induced M1 polarization, LTB4 secretion, and migration of neutrophils. Taken together, these findings demonstrate the polarization of M1 macrophages by Mitsui-7 MWCNTs in vitro and that induction of Alox5 is an important mechanism by which the MWCNTs promote proinflammatory responses by boosting M1 polarization and production of proinflammatory LMs.
National Survey of Substance Abuse Treatment Services: State Profiles 2012

The 2012 National Survey of Substance Abuse Treatment Services (N-SSATS) is an annual survey of facilities providing substance abuse treatment. The N-SSATS, conducted by the Substance Abuse and Mental Health Services Administration (SAMHSA), is designed to collect data on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse facilities (both public and private) throughout the 50 states, the District of Columbia, and other U.S. jurisdictions.
Compound 530313: Heptadecanoic acid, 2-trimethylsilyloxy, methyl ester

Chemical compound data from PubChem database. IUPAC Name: methyl 2-trimethylsilyloxyheptadecanoate. Molecular Formula: C21H44O3Si. Molecular Weight: 372.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 525857: N,N-Dimethyl-2-phenyl-N'-(4-methylphenyl)-acetamidine

Chemical compound data from PubChem database. IUPAC Name: N,N-dimethyl-N'-(4-methylphenyl)-2-phenylethanimidamide. Molecular Formula: C17H20N2. Molecular Weight: 252.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528770: Tricyclo[5.2.1.0(2.6)]dec-3-ene, 4-methyl-8-methylene

Chemical compound data from PubChem database. IUPAC Name: 4-methyl-8-methylidenetricyclo[5.2.1.02,6]dec-3-ene. Molecular Formula: C12H16. Molecular Weight: 160.25. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
VSRR - State and National Provisional Counts for Live Births, Deaths, and Infant Deaths

NOTES: Figures include all revisions received from the states and, therefore, may differ from those previously published. Data are provisional and are subject to monthly reporting variation. National data are calculated by summing the number of events reported by state of residence; counts are rounded to the nearest thousand (births and deaths) or hundred (infant deaths). Provisional counts may differ by approximately 2% from final counts, due to rounding and reporting variation. Additionally, the accuracy of the provisional counts may change over time. Data are estimates by state of residence. For discussion of the nature, source, and limitations of the data, see "Technical Notes" of the report, Births, Marriages, Divorces, and Deaths: Provisional Data for 2009. Available from URL: http://www.cdc.gov/nchs/data/nvsr/nvsr58/nvsr58_25.htm. Final counts of births, deaths, and infant deaths for previous years can be obtained from http://wonder.cdc.gov.

SOURCE: Provisional data from the National Vital Statistics System, National Center for Health Statistics, CDC.
Arkansas 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.
Compound 529795: Isopropyl-9-hexadecenoate

Chemical compound data from PubChem database. IUPAC Name: propan-2-yl hexadec-9-enoate. Molecular Formula: C19H36O2. Molecular Weight: 296.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
NNDSS - TABLE 1II. Tetanus to Trichinellosis

NNDSS - TABLE 1II. Tetanus to Trichinellosis – 2020. In this Table, provisional cases* of notifiable diseases are displayed for United States, U.S. territories, and Non-U.S. residents.

Note:
This table contains provisional cases of national notifiable diseases from the National Notifiable Diseases Surveillance System (NNDSS). NNDSS data from the 50 states, New York City, the District of Columbia and the U.S. territories are collated and published weekly on the NNDSS Data and Statistics web page (https://wwwn.cdc.gov/nndss/data-and-statistics.html). Cases reported by state health departments to CDC for weekly publication are provisional because of the time needed to complete case follow-up. Therefore, numbers presented in later weeks may reflect changes made to these counts as additional information becomes available. The national surveillance case definitions used to define a case are available on the NNDSS web site at https://wwwn.cdc.gov/nndss/. Information about the weekly provisional data and guides to interpreting data are available at: https://wwwn.cdc.gov/nndss/infectious-tables.html.

Footnotes:
U: Unavailable — The reporting jurisdiction was unable to send the data to CDC or CDC was unable to process the data.
-: No reported cases — The reporting jurisdiction did not submit any cases to CDC.
N: Not reportable — The disease or condition was not reportable by law, statute, or regulation in the reporting jurisdiction.
NN: Not nationally notifiable — This condition was not designated as being nationally notifiable.
NP: Nationally notifiable but not published.
NC: Not calculated — There is insufficient data available to support the calculation of this statistic.
Cum: Cumulative year-to-date counts.
Max: Maximum — Maximum case count during the previous 52 weeks.
* Case counts for reporting years 2019 and 2020 are provisional and subject to change. Cases are assigned to the reporting jurisdiction submitting the case to NNDSS, if the case's country of usual residence is the U.S., a U.S. territory, unknown, or null (i.e. country not reported); otherwise, the case is assigned to the 'Non-U.S. Residents' category. Country of usual residence is currently not reported by all jurisdictions or for all conditions. For further information on interpretation of these data, see https://wwwn.cdc.gov/nndss/document/Users_guide_WONDER_tables_cleared_final.pdf.
†Previous 52 week maximum and cumulative YTD are determined from periods of time when the condition was reportable in the jurisdiction (i.e., may be less than 52 weeks of data or incomplete YTD data).
Procainamide hydrochloride

Procainamide Hydrochloride is a prescription antiarrhythmic medication used to treat certain irregular heart rhythms. It is available as an injectable solution in strengths of 100 mg/mL and 500 mg/mL, administered via intramuscular or intravenous injection. Manufactured by Gland Pharma Limited and others under ANDA218135. This information was generated using AI and is provided for informational and research purposes only.
Reliability, validity and psychometric properties of the Greek translation of the zung depression rating scale

Introduction
          The current study aimed to assess the reliability, validity and psychometric properties of the Greek translation of the Zung Depression Rating Scale (ZDRS).
        
        
          Methods
          The study sample included 40 depressed patients 29.65 ± 9.38 years old and 120 normal comparison subjects 27.23 ± 10.62 years old. In 20 of them (12 patients and 8 comparison subjects) the instrument was re-applied 1–2 days later. Translation and Back Translation was made. Clinical Diagnosis was reached by consensus of two examiners with the use of the SCAN v.2.0 and the IPDE. Statistical Analysis included ANOVA, the Pearson Product Moment Correlation Coefficient, Principal Components Analysis and Discriminant Function Analysis and the calculation of Cronbach's alpha (α)
        
        
          Results
          Both Sensitivity and specificity exceed 90.00 at 44/45, Chronbach's alpha for the total scale was equal to 0.09, suggesting that the scale covers a broad spectrum of symptoms. Factor analysis revealed five factors (anxiety-depression, thought content, gastrenterological symptoms, irritability and social-interpersonal functioning). The test-retest reliability was satisfactory (Pearson's R between 0.92).
        
        
          Conclusion
          The ZDRS-Greek translation is both reliable and valid and is suitable for clinical and research use with satisfactory properties. Its properties are similar to those reported in the international literature, although the literature is limited. However one should always have in mind the limitations inherent in the use of self-report scales.
Daily Census Tract-Level PM2.5 Concentrations, 2001-2005

This dataset provides modeled predictions of PM2.5 levels from the EPA's Downscaler model. Data are at the census tract level for 2001-2005. These data are used by the CDC's National Environmental Public Health Tracking Network to generate air quality measures. Census tract-level datasets contain estimates of the mean predicted concentration and associated standard error. Please refer to the metadata attachment for more information.

Learn more about outdoor air quality on the Tracking Network's website: https://ephtracking.cdc.gov/showAirLanding.action.

By using these data, you signify your agreement to comply with the following requirements:
1. Use the data for statistical reporting and analysis only.
2. Do not attempt to learn the identity of any person included in the data and do not combine these data with other data for the purpose of matching records to identify individuals.
3. Do not disclose of or make use of the identity of any person or establishment discovered inadvertently and report the discovery to: trackingsupport@cdc.gov.
4. Do not imply or state, either in written or oral form, that interpretations based on the data are those of the original data sources and CDC unless the data user and data source are formally collaborating.
5. Acknowledge, in all reports or presentations based on these data, the original source of the data and CDC.
6. Suggested citation: Centers for Disease Control and Prevention. National Environmental Public Health Tracking Network. Web. Accessed: insert date. www.cdc.gov/ephtracking.
Compound 526714: Pentaethylene glycol, nonyl ether, TMS

Chemical compound data from PubChem database. IUPAC Name: trimethyl-[2-[2-[2-[2-(2-nonoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]silane. Molecular Formula: C22H48O6Si. Molecular Weight: 436.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Massachusetts (MA)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Massachusetts for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.
State Requirements for Electing Title IV-E Prevention and Family Services and Programs

The purpose of this Program Instruction (PI) is to instruct state title IV-E agencies on the title IV-E prevention program requirements and on the flexibility such agencies may provide to tribes with whom they have agreements under section 472(a)(2)(B)(ii) of the Act. ACF-ACYF-CB-PI-24-10 supersedes ACF-ACYF-CB-PI-24-07 issued May 21, 2024, upon publication.

Metadata-only record linking to the original dataset. Open original dataset below.
Compound 526785: 7-Hydroxy-nonadecanoic, methyl ester, tBDMS ether

Chemical compound data from PubChem database. IUPAC Name: methyl 7-[tert-butyl(dimethyl)silyl]oxynonadecanoate. Molecular Formula: C26H54O3Si. Molecular Weight: 442.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528683: Benzene, 1-(1-methylethyl)-2-propyl

Chemical compound data from PubChem database. IUPAC Name: 1-propan-2-yl-2-propylbenzene. Molecular Formula: C12H18. Molecular Weight: 162.27. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Reversible renal impairment induced by treatment with the angiotensin II receptor antagonist candesartan in a patient with bilateral renal artery stenosis

Background
          It is well established that ACE-inhibitors should be avoided in patients with renal artery stenosis. In recent years it has also been recommended that caution should be demonstrated when angiotensin II blockers are used in the same type of patients but the evidence is based only on few cases.
        
        
          Results
          We describe a case where use of the angiotensin II antagonist candesartan (Atacand) induced renal failure in a patient with bilateral renal artery stenosis. The course of the case is enlighted by results from sequential renography, selective renal vein catheterisation for measurement of renin, and angiographic findings.
        
        
          Conclusions
          In patients with renal artery stenosis the angiotensin II antagonist candesartan should be avoided.