AndreaBozzo/ceres-open-data-index huggingface dataset:
Systematic reviews of complementary therapies – an annotated bibliography. Part 2: Herbal medicine

Background
          Complementary therapies are widespread but controversial. We aim to provide a comprehensive collection and a summary of systematic reviews of clinical trials in three major complementary therapies (acupuncture, herbal medicine, homeopathy). This article is dealing with herbal medicine. Potentially relevant reviews were searched through the register of the Cochrane Complementary Medicine Field, the Cochrane Library, Medline, and bibliographies of articles and books. To be included articles had to review prospective clinical trials of herbal medicines; had to describe review methods explicitly; had to be published; and had to focus on treatment effects. Information on conditions, interventions, methods, results and conclusions was extracted using a pre-tested form and summarized descriptively.
        
        
          Results
          From a total of 79 potentially relevant reviews pre-selected in the screening process 58 met the inclusion criteria. Thirty of the reports reviewed ginkgo (for dementia, intermittent claudication, tinnitus, and macular degeneration), hypericum (for depression) or garlic preparations (for cardiovascular risk factors and lower limb atherosclerosis). The quality of primary studies was criticized in the majority of the reviews. Most reviews judged the available evidence as promising but definitive conclusions were rarely possible.
        
        
          Conclusions
          Systematic reviews are available on a broad range of herbal preparations prescribed for defined conditions. There is very little evidence on the effectiveness of herbalism as practised by specialist herbalists who combine herbs and use unconventional diagnosis.
Compound 527086: 9,13,17-Trimethyltritriacontane

Chemical compound data from PubChem database. IUPAC Name: 9,13,17-trimethyltritriacontane. Molecular Formula: C36H74. Molecular Weight: 507.0. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 526800: 3-Hydroxy-nonadecanoic, methyl ester, 3-tBDMS ether

Chemical compound data from PubChem database. IUPAC Name: methyl 3-[tert-butyl(dimethyl)silyl]oxynonadecanoate. Molecular Formula: C26H54O3Si. Molecular Weight: 442.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528113: 2-Chloro-5-isobutyl-3-methylpyrazine

Chemical compound data from PubChem database. IUPAC Name: 2-chloro-3-methyl-5-(2-methylpropyl)pyrazine. Molecular Formula: C9H13ClN2. Molecular Weight: 184.66. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E401607-T1: [Translated] METHOD FOR FACILITATING CONVERSION BETWEEN ASYNCHRONOUS AND SYNCHRONOUS DOMAIN

An interface for use between an asynchronous domain and a synchronous domain is described. The asynchronous domain is characterized by transmission of data in accordance with a delay-insensitive handshake protocol. The synchronous domain is characterized by transmission of data in accordance with transitions of a clock signal. The interface includes a datapath operable to transfer a data token between the domains. The interface also includes control circuitry operable to enable transfer of the data token via the datapath in response to a transition of the clock signal and at least one completion of the handshake protocol.
Compound 530251: (1r,2r,3r,5r)-5-Methyl-2-(1-methylethyl)cyclohexane-1,3-diol

Chemical compound data from PubChem database. IUPAC Name: 5-methyl-2-propan-2-ylcyclohexane-1,3-diol. Molecular Formula: C10H20O2. Molecular Weight: 172.26. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 526007: 5-Hydroxyhexanoic acid diTMS

Chemical compound data from PubChem database. IUPAC Name: trimethylsilyl 5-trimethylsilyloxyhexanoate. Molecular Formula: C12H28O3Si2. Molecular Weight: 276.52. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E400676-T1: [Translated] DEVICE FOR THE ELECTROLYTIC SURFACE PROCESSING OF METALS

The electrolytic action torch (2, 12, 19, 22, 26) for the surface treatment of metals, comprises a nib (4, 11) connected with the unipolar supply of electric current (7) from an external apparatus, the other pole being connected with the metal surface being treated and a device for protecting the operator from the gases and vapors generated, and the protection device consists of a member suitable for providing the area of the nib with a flow of pressurized air (3, 5, 9, 23, 27, 29, 36). Different integrated and non-integrated embodiments of the delivery member of air in the vicinity of the nib are described.
Compound 527675: Butanoic acid, 2-chloro, 1-methylbutyl ester

Chemical compound data from PubChem database. IUPAC Name: pentan-2-yl 2-chlorobutanoate. Molecular Formula: C9H17ClO2. Molecular Weight: 192.68. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
RESP-LENS

During the 2022-23 and 2023-24 respiratory illness seasons, the Respiratory Virus Laboratory Emergency Department Network Surveillance (RESP-LENS) system gathered electronic health record (EHR) data from nearly 100 hospitals associated with 24 participating sites located in 20 states and the District of Columbia. There was at least one site in each of the 10 Health and Human Services (HHS) regions. RESP-LENS collected reports of emergency department (ED) visits for acute respiratory illness (ARI) and corresponding viral testing results for SARS-CoV-2 (the virus that causes COVID-19), influenza (flu), and respiratory syncytial virus (RSV).  Sites reported data for an average of approximately 77,000 ED visits weekly, of which 11,000 were associated with ARI and 4,000 of those were in children younger than 18 years.  Between May 2023 and August 2024, these data were posted to CDC's RESP-LENS public dashboard, showing number tested, number positive, and percent positive for each of the three viruses mentioned, by virus, region, and age group.  Due to budget constraints, RESP-LENS was not funded beyond the end of the 2024 fiscal year.  RESP-LENS served as a valuable tool for public health and health care professionals and allowed users to visualize and understand trends in virus circulation, estimate disease burden, respond to outbreaks, and inform decisions and strategies for protecting public health.
Compound 527827: Gly-Pro, butyl ester, TFA

Chemical compound data from PubChem database. IUPAC Name: butyl 2-[[1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carbonyl]amino]acetate. Molecular Formula: C13H19F3N2O4. Molecular Weight: 324.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
2014 CMHS Uniform Reporting System (URS) Table for Arkansas

2014 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Arkansas. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
Interkingdom gene fusions

Background:
          Genome comparisons have revealed major lateral gene transfer between the three primary kingdoms of life - Bacteria, Archaea, and Eukarya. Another important evolutionary phenomenon involves the evolutionary mobility of protein domains that form versatile multidomain architectures. We were interested in investigating the possibility of a combination of these phenomena, with an invading gene merging with a pre-existing gene in the recipient genome.
        
        
          Results:
          Complete genomes of fifteen bacteria, four archaea and one eukaryote were searched for interkingdom gene fusions (IKFs); that is, genes coding for proteins that apparently consist of domains originating from different primary kingdoms. Phylogenetic analysis supported 37 cases of IKF, each of which includes a 'native' domain and a horizontally acquired 'alien' domain. IKFs could have evolved via lateral transfer of a gene coding for the alien domain (or a larger protein containing this domain) followed by recombination with a native gene. For several IKFs, this scenario is supported by the presence of a gene coding for a second, stand-alone version of the alien domain in the recipient genome. Among the genomes investigated, the greatest number of IKFs has been detected in Mycobacterium tuberculosis, where they are almost always accompanied by a stand-alone alien domain. For most of the IKF cases detected in other genomes, the stand-alone counterpart is missing.
        
        
          Conclusions:
          The results of comparative genome analysis show that IKF formation is a real, but relatively rare, evolutionary phenomenon. We hypothesize that IKFs are formed primarily via the proposed two-stage mechanism, but other than in the Actinomycetes, in which IKF generation seems to be an active, ongoing process, most of the stand-alone intermediates have been eliminated, perhaps because of functional redundancy.
HCUP State Inpatient Databases (SID) - Restricted Access File

The Healthcare Cost and Utilization Project (HCUP) State Inpatient Databases (SID) are a set of hospital databases that contain the universe of hospital inpatient discharge abstracts from data organizations in participating States. The data are translated into a uniform format to facilitate multi-State comparisons and analyses. The SID are based on data from short term, acute care, nonfederal hospitals. Some States include discharges from specialty facilities, such as acute psychiatric hospitals. The SID include all patients, regardless of payer and contain clinical and resource use information included in a typical discharge abstract, with safeguards to protect the privacy of individual patients, physicians, and hospitals (as required by data sources). Developed through a Federal-State-Industry partnership sponsored by the Agency for Healthcare Research and Quality (AHRQ), HCUP data inform decision making at the national, State, and community levels.

The SID contain clinical and resource-use information that is included in a typical discharge abstract, with safeguards to protect the privacy of individual patients, physicians, and hospitals (as required by data sources). Data elements include but are not limited to: diagnoses, procedures, admission and discharge status, patient demographics (e.g., sex, age), total charges, length of stay, and expected payment source, including but not limited to Medicare, Medicaid, private insurance, self-pay, or those billed as ‘no charge’. In addition to the core set of uniform data elements common to all SID, some include State-specific data elements. The SID exclude data elements that could directly or indirectly identify individuals. For some States, hospital and county identifiers are included that permit linkage to the American Hospital Association Annual Survey File and county-level data from the Bureau of Health Professions' Area Resource File except in States that do not allow the release of hospital identifiers.

Restricted access data files are available with a data use agreement and brief online security training.
Adult Day Care Centers

[<a href='https://files.hawaii.gov/dbedt/op/gis/data/Adult_Day_Care_Centers.pdf' target='_blank' rel='nofollow ugc noopener noreferrer'>Metadata</a>] Locations of adult day care centers in the State of Hawaii as of November 2021. Source: Created by Hawaii Statewide GIS Program from data downloaded from Hawaii State Department of Health Office of Health Care Assurance (OHCA), November 2021. For more information, please see metadata at <a href='https://files.hawaii.gov/dbedt/op/gis/data/Adult_Day_Care_Centers.pdf' target='_blank' rel='nofollow ugc noopener noreferrer'>https://files.hawaii.gov/dbedt/op/gis/data/Adult_Day_Care_Centers.pdf</a> or contact Hawaii Statewide GIS Program, Office of Planning and Sustainable Development, State of Hawaii; PO Box 2359, Honolulu, Hi. 96804; (808) 587-2846; email: <a href='mailto:gis@hawaii.gov' target='_blank' rel='nofollow ugc noopener noreferrer'>gis@hawaii.gov</a>; Website: <a href='https://planning.hawaii.gov/gis' target='_blank' rel='nofollow ugc noopener noreferrer'>https//planning.hawaii.gov/gis</a>.
Longitudinal impact of a youth tobacco education program

Background
          Information on the effectiveness of elementary school level, tobacco-use prevention programs is generally limited. This study assessed the impact of a structured, one-time intervention that was designed to modify attitudes and knowledge about tobacco. Participants were fifth-grade students from schools in western New York State.
        
        
          Methods
          Twenty-eight schools, which were in relatively close geographic proximity, were randomized into three groups; Group 1 was used to assess whether attitudes/knowledge were changed in the hypothesized direction by the intervention, and if those changes were retained four months later. Groups 2 and 3, were used as comparison groups to assess possible test-retest bias and historical effects. Groups 1 and 3 were pooled to assess whether attitudes/knowledge were changed by the intervention as measured by an immediate post-test. The non-parametric analytical techniques of Wilcoxon-Matched Pairs/Sign Ranks and the Mann-Whitney-Wilcoxon Rank Sums Tests were used to compare proportions of correct responses at each of the schools.
        
        
          Results
          Pooled analyses showed that short-term retention on most items was achieved. It was also found that retention on two knowledge items 'recognition that smokers have yellow teeth and fingers' and 'smoking one pack of cigarettes a day costs several hundred dollars per year' was maintained for four months.
        
        
          Conclusions
          The findings suggest that inexpensive, one-time interventions for tobacco-use prevention can be of value. Changes in attitudes and knowledge conducive to the goal of tobacco-use prevention can be achieved for short-term retention and some relevant knowledge items can be retained for several months.
Cell-cell interactions in synovitis: Antigen presenting cells and T cell interaction in rheumatoid arthritis

The synovial tissue in rheumatoid arthritis (RA) patients is enriched with mature antigen presenting cells (APCs) and many T lymphocytes. Interactions between APCs and T cells are essential for the initiation and amplification of T-cell-dependent immune responses, and may therefore play an important role in the chronic inflammatory processes in the synovium. The nature of the antigen(s) involved in RA still remains elusive. However, interactions and signaling through the costimulatory molecules CD28-CD80/86 and CD40-CD40L are critical during APC–T cell interaction for optimal cell activation. This review discusses how such costimulatory signals can be involved in the initiation and amplification of the inflammatory reactions in the synovium. Blocking of the signaling pathways involved in APC–T cell interactions might provide a specific immuno-therapeutic approach for the treatment of RA.
Differences in Cumulative Influenza Vaccination Coverage by Selected Demographics, Adults 18 Year and Older, NIS Adult COVID Module

Differences in Cumulative Influenza Vaccination Coverage by Selected Demographics, Adults 18 Year and Older, NIS Adult COVID Module

• The National Immunization Survey-Adult COVID Module (NIS-ACM) was launched in April 2021 among adults 18 years and older. The survey was used to monitor COVID-19 vaccination uptake and confidence in vaccination among adults and included questions about influenza vaccination.
Comparative evaluation of gene delivery devices in primary cultures of rat hepatic stellate cells and rat myofibroblasts

Background
          The hepatic stellate cell is the primary cell type responsible for the excessive formation and deposition of connective tissue elements during the development of hepatic fibrosis in chronically injured liver. Culturing quiescent hepatic stellate cells on plastic causes spontaneous activation leading to a myofibroblastic phenotype similar to that seen in vivo. This provides a simple model system for studying activation and transdifferentiation of these cells. The introduction of exogenous DNA into these cells is discussed controversially mainly due to the lack of systematic analysis. Therefore, we examined comparatively five nonviral, lipid-mediated gene transfer methods and adenoviral based infection, as potential tools for efficient delivery of DNA to rat hepatic stellate cells and their transdifferentiated counterpart, i.e. myofibroblasts. Transfection conditions were determined using enhanced green fluorescent protein as a reporter expressed under the transcriptional control of the human cytomegalovirus immediate early gene 1 promoter/enhancer.
        
        
          Results
          With the use of chemically enhanced transfection methods, the highest relative efficiency was obtained with FuGENE™6 gene mediated DNA transfer. Quantitative evaluation of representative transfection experiments by flow cytometry revealed that approximately 6% of the rat hepatic stellate cells were transfected. None of the transfection methods tested was able to mediate gene delivery to rat myofibroblasts. To analyze if rat hepatic stellate cells and myofibroblasts are susceptible to adenoviral infection, we have inserted the transgenic expression cassette into a recombinant adenoviral type 5 genome as replacement for the E1 region. Viral particles of this replication-deficient Ad5-based reporter are able to infect 100% of rat hepatic stellate cells and myofibroblasts, respectively.
        
        
          Conclusions
          Our results indicate that FuGENE™6-based methods may be optimized sufficiently to offer a feasible approach for gene transfer into rat hepatic stellate cells. The data further demonstrate that adenoviral mediated transfer is a promising approach for gene delivery to these hepatic cells.
Islet expression of the DNA repair enzyme 8-oxoguanosine DNA glycosylase (Ogg1) in human type 2 diabetes

Background
          It has become increasingly clear that β-cell failure plays a critical role in the pathogenesis of type 2 diabetes. Free-radical mediated β-cell damage has been intensively studied in type 1 diabetes, but not in human type 2 diabetes. Therefore, we studied the protein expression of the DNA repair enzyme Ogg1 in pancreases from type 2 diabetics. Ogg1 was studied because it is the major enzyme involved in repairing 7,8-dihydro-8-oxoguanosine DNA adducts, a lesion previously observed in a rat model of type 2 diabetes. Moreover, in a gene expression screen, Ogg1 was over-expressed in islets from a human type 2 diabetic.
        
        
          Methods
          Immunofluorescent staining of Ogg1 was performed on pancreatic specimens from healthy controls and patients with diabetes for 2–23 years. The intensity and islet area stained for Ogg1 was evaluated by semi-quantitative scoring.
        
        
          Results
          Both the intensity and the area of islet Ogg1 staining were significantly increased in islets from the type 2 diabetic subjects compared to the healthy controls. A correlation between increased Ogg1 fluorescent staining intensity and duration of diabetes was also found. Most of the staining observed was cytoplasmic, suggesting that mitochondrial Ogg1 accounts primarily for the increased Ogg1 expression.
        
        
          Conclusion
          We conclude that oxidative stress related DNA damage may be a novel important factor in the pathogenesis of human type 2 diabetes. An increase of Ogg1 in islet cell mitochondria is consistent with a model in which hyperglycemia and consequent increased β-cell oxidative metabolism lead to DNA damage and the induction of Ogg1 expression.
Child Maltreatment 2015

This report presents national data about child abuse and neglect known to child protective services agencies in the United States during federal fiscal year 2015.

Letter from the Commissioner

Acknowledgements

Summary

Chapter 1: Introduction

Chapter 2: Reports

Chapter 3: Children

Chapter 4: Fatalities

Chapter 5: Perpetrators

Chapter 6: Services

Appendix A: Required CAPTA Data Items

Appendix B: Glossary

Appendix C: State Characteristics

Appendix D: State Commentary

Metadata-only record linking to the original dataset. Open original dataset below.
Patent AT-E401453-T1: [Translated] METHOD AND DIRECTIONAL AID FOR SETTING UP THE POSITION OF A PRECAST CONCRETE Slab AND PRECAST CONCRETE Slab

The invention relates to a method for adjusting the position of a precast concrete slab (1), in particular to the support pillar for a carriage way for high-speed transport means. The inventive slab (1) is supported by a foundation consisting of a sub-layer made of a hardenable material and a base bearing layer (5) of the foundation and is brought into a predetermined position prior to the sub-layer arrangement with the aid of several vertical bars (11) which are used as auxiliary adjusting elements (4, 4'). The inventive method is characterised in that at least two vertical bars (11) rest against a bearing block (13) which is disposed on the bearing layer (5) and displaceable in a longitudinal and/or transversal direction of the slab (1). Said invention makes it possible to arrange the appropriate auxiliary adjusting means and a corresponding precast slab.