AndreaBozzo/ceres-open-data-index huggingface dataset:
Antinociceptive and antiedematogenic properties and acute toxicity of

Background
          Tabebuia avellanedae is a tree from the Bignoniaceae family. Commonly know as "pau d'arco" in Brazil, its inner bark is used as analgesic, anti-inflammatory, antineoplasic and diuretic at the Brazilian northeast. A validation of the plant usage has not been previously performed.
        
        
          Results
          Antinociceptive and antiedematogenic effects of Tabebuia avellanedae Lor. ex Griseb. inner bark were measured by nociceptive experimental models in mice. A rat paw edema test induced by carrageenan (1%) was also performed in rats to access the plant's antiedematogenic effect. The inner bark aqueous extract, administered via oral in three different concentration, namely 100, 200 and 400 mg/Kg, reduced the nociception produced by acetic acid (0.6% in water, i.p.) by 49.9%, 63.7% and 43.8%, respectively. The aqueous extract (200 and 400 mg/Kg, p.o.) reduced formalin (1%) effects only at the second phase of the experiment by 49.3% and 53.7%, respectively. Naloxone (5 mg/Kg, i.p.) was not able to revert the extract effect, however caffeine (10 mg/Kg, i.p.) reverted its effect by 19.8% at the second phase of the formalin test. The aqueous extract (200 mg/Kg, p.o.) inhibited edema by 12.9% when we used the rat paw edema model. The acute toxicity was low in mice.
        
        
          Conclusion
          The T. avellanedae inner bark aqueous extract presented antinociceptive and antiedematogenic activities at the used models, with a possible antinociceptive effect associated to the adenosine system.
Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC)

<p>The Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC) facilitates finding and comparing neuroimaging resources for functional and structural neuroimaging analyses—including popular tools as well as those that once might have been hidden in another researcher's laboratory or some obscure corner of cyberspace. NITRC collects and points to standardized information about tools, making the task of finding and comparing them easier than before. The site can help researchers find the right functional or structural neuroimaging tool or resource for their research. NITRC has recently added services such as cloud-based computing and data storage, and is broadening the range of scientific domains from MR to PET, SPECT, CT, MEG/EEG and optical imaging. Additional domains of interest are digital atlasing, and computational neuroscience, including large-scale and multi-scale modeling. The NITRC team searches out relevant research tools and resources to house on the site. Researchers can compare tools on NITRC and developers can seek and receive help from the community to make their tools more usable and accessible.</p>
Compound 528208: Benzoic acid, 2-hydroxy-3-methyl-4-methoxy, DTBS

Chemical compound data from PubChem database. IUPAC Name: 2,2-ditert-butyl-7-methoxy-8-methyl-1,3,2-benzodioxasilin-4-one. Molecular Formula: C17H26O4Si. Molecular Weight: 322.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Dorzolamide hydrochloride and timolol maleate

Dorzolamide Hydrochloride and Timolol Maleate is a prescription eye drop solution used to lower pressure inside the eye, often for treating glaucoma or ocular hypertension. It combines two medications: dorzolamide (a carbonic anhydrase inhibitor) and timolol (a beta-blocker) to reduce fluid production in the eye. Manufactured by Somerset Therapeutics, LLC, it's available as a 10 mL bottle. This information was generated using AI and is provided for informational and research purposes only.
Effects of chronic inflammatory bowel diseases on left ventricular structure and function: a study protocol

Background
          Experimental evidences suggest an increased collagen deposition in inflammatory bowel diseases (IBD). In particular, large amounts of collagen type I, III and V have been described and correlated to the development of intestinal fibrotic lesions. No information has been available until now  about the possible increased collagen deposition far from the main target organ. In the hypothesis that chronic inflammation and increased collagen metabolism are reflected also in the systemic circulation, we aimed this study to evaluate the effects on left ventricular wall structure by assessing splancnic and systemic collagen metabolism (procollagen III assay), deposition (ultrasonic tissue characterization), and cardiac function (echocardiography) in patients with different long standing history of IBD, before and after surgery.
        
        
          Methods
          Thirty patients affected by active IBD, 15 with Crohn and 15 with Ulcerative Colitis, submitted to surgery will be enrolled in the study in a double blind fashion. They will be studied before the surgical operation and 6, 12 months after surgery. A control group of 15 healthy age and gender-matched subjects will also be studied. At each interval blood samples will be collected in order to assess the collagen metabolism; a transthoracic echocardiogram will be recorded for the subsequent determination of cardiac function and collagen deposition.
        
        
          Discussion
          From this study protocol we expect additional information about the association between IBD and cardiovascular disorders; in particular to address the question if chronic inflammation, through the altered collagen metabolism, could affect left ventricular structure and function in a manner directly related to the estimated duration of the disease.
COVID-19 Vaccines Up to Date Status

This site provides historical data beginning June 14, 2023, for the visualization presented on <a href="https://covid.cdc.gov/covid-data-tracker/#vaccinations">COVID-19 Data Tracker’s “Vaccinations in the United States</a>” site titled “Percent of Total Population Who Are Up to Date with COVID-19 Vaccines”

<b>Definition for Up to Date:
For surveillance purposes people are ‘Upto Date’ with COVID-19 vaccines based on the following criteria:</b>

People ages 6 years and older: Are up to date if they received 1 updated Pfizer-BioNTech or Moderna COVID-19 vaccine. 

Children ages 6 months to 5 years who received the Pfizer-BioNTech COVID-19 vaccine: Are up to date if: At ages 6 months to 4 years, they received 3 COVID-19 vaccine doses, including at least 1 updated COVID-19 dose; at age 5 years, they received at least 1 updated COVID-19 vaccine dose. 

Children ages 6 months to 5 years who received the Moderna COVID-19 vaccine: Are up to date if they received 2 Moderna COVID-19 vaccine doses, including at least 1 updated COVID-19 vaccine dose. 

People who are unable or choose not to get a recommended mRNA vaccine: Are up to date if they receive the Novavax COVID-19 vaccine doses approved for their age group.

CDC uses US Census estimates for the total populations within each specified demographic group regardless of prior vaccination status as denominators. 

Data represents all vaccine partners including jurisdictional partner clinics, retail pharmacies, long-term care facilities, dialysis centers, Federal Emergency Management Agency and Health Resources and Services Administration partner sites, and federal entity facilities.
Effects of Meaningful Use Functionalities on Health Care Quality, Safety, and Efficiency

The Updated Systematic Review reviews the January 2010 to August 2013 health IT literature to examine the effects of health IT across three aspects of care: efficiency, quality, and safety. This report updates previous systematic reviews of the health IT literature, focusing specifically on identifying and summarizing the evidence related to the use of health IT as outlined in the Meaningful Use regulations. The review examined the literature to determine the article authors' findings related to the effects or associations of a meaningful use functionality on an aspect of care. Each article's findings was scored as positive (defined as: health IT improved key aspect of care but none worse off), mixed-positive (defined as: positive effects of health IT outweight negative effects), neutral (defined as: health IT not associated with change in outcome), or negative (defined as: negative effects of health IT on outcome). The full review data: article, related meaningful use functionality, aspect of care, and author sentiment are provided in this dataset.
Early inflammatory markers in elicitation of allergic contact dermatitis

Background
          Allergic Contact Dermatitis (ACD) is regarded as a T-cell-mediated delayed-type hypersensitivity reaction. We studied the kinetics of the expression of CS-1 fibronectin, thymus and activation-regulated chemokine (CCL17/ TARC) and different chemokine receptors (CR) in skin biopsies from individuals suffering from back problems, with the antigen responsible of their contact dermatitis and an irrelevant antigen.
        
        
          Methods
          Samples were taken at 2, 10, and 48 hours for histological and immunohistochemical studies using monoclonal antibodies against human CS-1 fibronectin, CCL17, CD3, CD68, CD49d, CXCR3, CCR5, and CCR3.
        
        
          Results
          At positive antigen stimulated sites there was an early expression of CS-1 fibronectin (2 hours), followed by CCL17 and a later accumulation of alplha4/beta1+ (CD49d), CD3+, CD68+, CXCR3+ and CCR5+ mononuclear cells. At 48 hours, approximately 59 % of infiltrating cells were CXCR3+, 42% CCR5+, and only 14 % CCR3+.
        
        
          Conclusions
          These results showed for the first time a very early expression of CS-1 fibronectin which preceded production of CCL17 in blood endothelial cells (BCEs) from patients' skin with ACD. The role of these molecules in recruitment of monocytes and effector T cells in ACD is discussed.
Compound 530456: p-Toluic acid, 1-adamantylmethyl ester

Chemical compound data from PubChem database. IUPAC Name: 1-adamantylmethyl 4-methylbenzoate. Molecular Formula: C19H24O2. Molecular Weight: 284.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
San Francisco – SF Div: Drug-Related Emergency Department Visits, 2004-2011 - Accidental Ingestions

Excel file with estimates, rates, relative standard errors, trends and confidence intervals, covering 2004-2011 for emergency department visits involving accidental ingestions in the San Francisco metropolitan area (San Francisco division). This analytic category includes ED visits in which an individual accidentally or unknowingly used or was administered a prescription drug, over-the-counter medication, or dietary supplement. Drug-related accidental ingestion typically involves patients aged 5 and under.  This analytic category does not include drug misuse or abuse.File includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol.  Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology.Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.
Developing and Sustaining a Parent Partner Program

This Child Welfare Information Gateway Podcast is available on Apple Podcasts
  
  

, Spotify
  
  

, Stitcher
  
  

, SoundCloud
  
  

, and the Child Welfare Information Gateway
  
  

 website. Subscribe to receive new episodes as they are released.

Metadata-only record linking to the original dataset. Open original dataset below.
Potential of (GATA)

Background
          The microsatellite, (GATA)n has been frequently used for DNA fingerprinting. However, very few attempts have been made to analyze (GATA)n-containing loci in rice.
        
        
          Results
          Three polymorphic (GATA)n-harboring loci viz. OS1A6, OS1H10 and OS2E7, containing 7–13 repeat motifs were identified from a genomic library of a cultivated rice, Oryza sativa var. Basmati-370 using oligonucleotide probe (GATA)4. When (GATA)n flanking primers were used to screen 26 wilds (representing different genomes of rice), 16 cultivars, 47 Indian elite rice varieties and 37 lines resistant/susceptible to bacterial blight, up to 22 alleles were obtained at an individual locus. Also, interestingly the bacterial blight resistant lines clustered into a separate group from the remaining rice genotypes, when a dendrogram was constructed based on the polymorphism obtained at the three loci. This may be due to the partial homology of the clones OS1H10 and OS2E7 to regions encoding O. longistaminata receptor kinase-like protein and pathogenesis-related protein. The ability of these O. sativa flanking primers to amplify DNA of maize, wheat, barley and oat indicates that these (GATA)n-containing loci are conserved across different cereal genera.
        
        
          Conclusions
          The large allele number obtained reveals the potential of (GATA)n-containing loci as powerful tools to detect simple sequence length polymorphism (SSLP). The (GATA)n-flanking primers were not only useful in distinguishing between closely related genotypes, but could also be used for cross-species amplification and are also conserved across different cereal genera. These loci could also cluster the bacterial blight resistant/susceptible lines into different groups based on the resistance genes present in them.
Compound 530714: o-Anisic acid, hex-4-yn-3-yl ester

Chemical compound data from PubChem database. IUPAC Name: hex-4-yn-3-yl 2-methoxybenzoate. Molecular Formula: C14H16O3. Molecular Weight: 232.27. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 526159: Dibutyl 4-chloro-phenyl phosphate

Chemical compound data from PubChem database. IUPAC Name: dibutyl (4-chlorophenyl) phosphate. Molecular Formula: C14H22ClO4P. Molecular Weight: 320.75. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
COVID-19 State Profile Report - South Dakota

<b>After over two years of public reporting, the State Profile Report will no longer be produced and distributed after February 2023. The final release was on February 23, 2023. We want to thank everyone who contributed to the design, production, and review of this report and we hope that it provided insight into the data trends throughout the COVID-19 pandemic.
Data about COVID-19 will continue to be updated at <a href='https://covid.cdc.gov/covid-data-tracker/#datatracker-home' >CDC’s COVID Data Tracker</a>.
 </b>

<p>
The State Profile Report (SPR) is generated by the Data Strategy and Execution Workgroup in the Joint Coordination Cell, in collaboration with the White House. It is managed by an interagency team with representatives from multiple agencies and offices (including the United States Department of Health and Human Services (HHS), the Centers for Disease Control and Prevention, the HHS Assistant Secretary for Preparedness and Response, and the Indian Health Service). The SPR provides easily interpretable information on key indicators for each state, down to the county level.
 </p>

It is a weekly snapshot in time that:
<ul>
<li>Focuses on recent outcomes in the last seven days and changes relative to the month prior</li>
<li>Provides additional contextual information at the county level for each state, and includes national level information</li>
<li>Supports rapid visual interpretation of results with color thresholds</li>
</ul>
Compound 529158: 1-Hexanamine, bis-TMS

Chemical compound data from PubChem database. IUPAC Name: N,N-bis(trimethylsilyl)hexan-1-amine. Molecular Formula: C12H31NSi2. Molecular Weight: 245.55. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Diltiazem hydrochloride

TiadyLT ER is a prescription medication containing diltiazem hydrochloride, a calcium channel blocker that helps relax blood vessels and improve blood flow to the heart. It's used to treat high blood pressure, chest pain (angina), and certain heart rhythm problems. Available as extended-release oral capsules in strengths from 120mg to 420mg, manufactured by Zydus Pharmaceuticals. This information was generated using AI and is provided for informational and research purposes only.
Compound 528248: 2-Ethenyl-5-propylthiophene

Chemical compound data from PubChem database. IUPAC Name: 2-ethenyl-5-propylthiophene. Molecular Formula: C9H12S. Molecular Weight: 152.26. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Missouri 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.
Compound 530337: Methyl docosa-7,10,13,16-tetraenoate

Chemical compound data from PubChem database. IUPAC Name: methyl docosa-7,10,13,16-tetraenoate. Molecular Formula: C23H38O2. Molecular Weight: 346.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Functional analysis of a frame-shift mutant of the dihydropyridine receptor pore subunit (α

Background
          The L-type Ca2+ channel formed by the dihydropyridine receptor (DHPR) of skeletal muscle senses the membrane voltage and opens the ryanodine receptor (RyR1). This channel-to-channel coupling is essential for Ca2+ signaling but poorly understood. We characterized a single-base frame-shift mutant of α1S, the pore subunit of the DHPR, that has the unusual ability to function voltage sensor for excitation-contraction (EC) coupling by virtue of expressing two complementary hemi-Ca2+ channel fragments.
        
        
          Results
          Functional analysis of cDNA transfected dysgenic myotubes lacking α1S were carried out using voltage-clamp, confocal Ca2+ indicator fluoresence, epitope immunofluorescence and immunoblots of expressed proteins. The frame-shift mutant (fs-α1S) expressed the N-terminal half of α1S (M1 to L670) and the C-terminal half starting at M701 separately. The C-terminal fragment was generated by an unexpected restart of translation of the fs-α1S message at M701 and was eliminated by a M701I mutation. Protein-protein complementation between the two fragments produced recovery of skeletal-type EC coupling but not L-type Ca2+ current.
        
        
          Discussion
          A premature stop codon in the II-III loop may not necessarily cause a loss of DHPR function due to a restart of translation within the II-III loop, presumably by a mechanism involving leaky ribosomal scanning. In these cases, function is recovered by expression of complementary protein fragments from the same cDNA. DHPR-RyR1 interactions can be achieved via protein-protein complementation between hemi-Ca2+ channel proteins, hence an intact II-III loop is not essential for coupling the DHPR voltage sensor to the opening of RyR1 channel.
Compound 528567: Hexanedioic acid, bis(tert-butyldimethylsilyl) ester

Chemical compound data from PubChem database. IUPAC Name: bis[tert-butyl(dimethyl)silyl] hexanedioate. Molecular Formula: C18H38O4Si2. Molecular Weight: 374.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
2024 National Directory of Drug and Alcohol Use Treatment Facilities

TheNational Directory of Drug and AlcoholUseTreatment Facilities - 2024is a listing of federal, state, and local government facilities and private facilities that provide substance use treatment services. It includes treatment facilities that (1) are licensed, certified, or otherwise approved for inclusion in the Directory by their State Substance Use Agencies, and (2) responded to the 2023 National Substance Use and Mental Health Services Survey (N-SUMHSS). The information about each facility that appears in this Directory was provided by that facility in response to the 2023 N-SUMHSS. The N-SUMHSS is conducted annually by the Substance Abuse and Mental Health Services Administration (SAMHSA). The 2024 Directory is available in PDF and Excel formats.The Directory is ordered alphabetically by state, by city within each state, and by facility name within each city. Each facility listing includes codes that represent the services offered and other features of the facility, including codes that indicate services for hearing impaired and non-English-speaking clients. Codes are defined in a key shown on pages v-x of the PDF file and as a separate tab on the Excel version. Please note services offered by a particular facility may change over time. It is suggested to verify the information in this Directory when contacting a facility.
Compound 529782: Acetic acid, 3,5-bis-(trifluoromethyl)phenylmethyl ester

Chemical compound data from PubChem database. IUPAC Name: [3,5-bis(trifluoromethyl)phenyl]methyl acetate. Molecular Formula: C11H8F6O2. Molecular Weight: 286.17. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E401609-T1: [Translated] LEXICON WITH DESCRIBED DATA AND PROCEDURES FOR THEIR CONSTRUCTION AND USE

A lexicon stored on a computer readable medium and used by language processing systems. The lexicon can store word information in a plurality of data fields associated with each entered word. The data fields can include information on spelling and grammar, parts of speech, steps that the entered word can be transformed into another word, a word description, and a segmentation for a compound word. Information that cannot be stored in the lexicon can be stored in an intermediate indexes table. Associated methods of constructing, updating and using the lexicon are introduced.
Patent AT-E401178-T1: [Translated] IMPROVEMENTS IN PRESENTATION AGENTS FOR WOOD BASED PRODUCTS

The present invention relates to a method of using triadimefon and/or triadimenol as a preservative for the protection of glued wood-based products against attack and destruction of microorganisms, especially where the triadimefon and/or triadimenol is applied during the manufacturing process of the glued wood-based products. The invention further relates to a preservative composition for the protection of glued wood-based products including triadimefon and/or triadimenol and articles having such compositions as a part the article.