AndreaBozzo/ceres-open-data-index huggingface dataset:
Generation of single-copy transgenic mouse embryos directly from ES cells by tetraploid embryo complementation

Background
          Transgenic mice have been used extensively to analyze gene function. Unfortunately, traditional transgenic procedures have only limited use in analyzing alleles that cause lethality because lines of founder mice cannot be established. This is frustrating given that such alleles often reveal crucial aspects of gene function. For this reason techniques that facilitate the generation of embryos expressing such alleles would be of enormous benefit. Although the transient generation of transgenic embryos has allowed limited analysis of lethal alleles, it is expensive, time consuming and technically challenging. Moreover a fundamental limitation with this approach is that each embryo generated is unique and transgene expression is highly variable due to the integration of different transgene copy numbers at random genomic sites.
        
        
          Results
          Here we describe an alternative method that allows the generation of clonal mouse embryos harboring a single-copy transgene at a defined genomic location. This was facilitated through the production of Hprt negative embryonic stem cells that allow the derivation of embryos by tetraploid embryo complementation. We show that targeting transgenes to the hprt locus in these ES cells by homologous recombination can be efficiently selected by growth in HAT medium. Moreover, embryos derived solely from targeted ES cells containing a single copy LacZ transgene under the control of the α-myosin heavy chain promoter exhibited the expected cardiac specific expression pattern.
        
        
          Conclusion
          Our results demonstrate that tetraploid embryo complementation by F3 hprt negative ES cells facilitates the generation of transgenic mouse embryos containing a single copy gene at a defined genomic locus. This approach is simple, extremely efficient and bypasses any requirement to generate chimeric mice. Moreover embryos generated by this procedure are clonal in that they are all derived from a single ES cell lines. This facilitates the comparative analysis of lethal alleles and thereby advances our ability to analyze gene function in mammals.
National Ambulatory Medical Care Survey Health Center Component, 2021-2024, restricted-use data

The National Ambulatory Medical Care Survey (NAMCS) Health Center Component, conducted by the National Center for Health Statistics (NCHS), collects annual data on visits to health centers to describe patterns of utilization and provision of ambulatory care delivery in the United States. Health centers are local clinics that are community-based and provide comprehensive health care services to populations that are often vulnerable and underserved. Health centers are either federally qualified health centers (FQHCs), which receive federal funding from the Health Resources and Services Administration (HRSA), or FQHC look-alikes, which meet HRSA requirements but do not receive HRSA funding.
Compound 528600: tert-Butyl(dimethyl)silyl tridecanoate

Chemical compound data from PubChem database. IUPAC Name: [tert-butyl(dimethyl)silyl] tridecanoate. Molecular Formula: C19H40O2Si. Molecular Weight: 328.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Publications Using SAMHSA DataBehavioral Health Barometer: Utah, 2013

This is a behavioral health report for the state of Utah. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment for the years 2008 to 2012.
National Health and Nutrition Examination Survey (NHANES) Genetic Restricted Data

DNA samples were collected in the <b>Third National Health and Nutrition Examination Survey</b> (NHANES III; 1988-1994) and in subsequent NHANES cycles (1999-2002, 2007-2008, 2009-2010, and 2011-2012). The program is a nationally representative collection of stored DNA samples and genetic data and will serve to add to the extensive amount of health, nutritional, and environmental information collected from NHANES. Resulting genetic variants are deposited into the NHANES Genetic Data Repository. These datasets are categorized as restricted data since they contain identifiable information.

For more information on the NHANES Genetic Data please visit: <a href="https://www.cdc.gov/nchs/nhanes/biospecimens/dnaspecimens.htm">NHANES DNA Specimens and Genetic Data Program at: https://www.cdc.gov/nchs/nhanes/biospecimens/dnaspecimens.htm.</a>
For more information on NHANES, visit the <a href="https://www.cdc.gov/nchs/nhanes/index.htm">NHANES - National Health and Nutrition Examination Survey Homepage at: https://www.cdc.gov/nchs/nhanes/index.htm.</a>
2014 CMHS Uniform Reporting System (URS) Table for Louisiana

2014 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Louisiana. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
Compound 526372: 1,2,4,7,9-Pentabromo-dibenzo-dioxin

Chemical compound data from PubChem database. IUPAC Name: 1,2,4,7,9-pentabromodibenzo-p-dioxin. Molecular Formula: C12H3Br5O2. Molecular Weight: 578.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 526573: 2,10-Dimethyldotriacontane

Chemical compound data from PubChem database. IUPAC Name: 2,10-dimethyldotriacontane. Molecular Formula: C34H70. Molecular Weight: 478.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 527162: Cyclocopacamphenol

Chemical compound data from PubChem database. IUPAC Name: 2-(1,2-dimethyl-8-tetracyclo[4.4.0.02,4.03,7]decanyl)propan-1-ol. Molecular Formula: C15H24O. Molecular Weight: 220.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 527276: Pentanoic acid, 4-methyl, 2-chloroethyl ester

Chemical compound data from PubChem database. IUPAC Name: 2-chloroethyl 4-methylpentanoate. Molecular Formula: C8H15ClO2. Molecular Weight: 178.65. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 530694: 2,3,4-Trifluorobenzoic acid, hex-4-yn-3-yl ester

Chemical compound data from PubChem database. IUPAC Name: hex-4-yn-3-yl 2,3,4-trifluorobenzoate. Molecular Formula: C13H11F3O2. Molecular Weight: 256.22. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E40049-T1: [Translated] METHODS FOR THE PRODUCTION OF HEPATITIS BO SURFACE ANTIGEN-FREE GAMMAGLOBULINES AND PRODUCTS.

Chemical patent from PubChem database. Patent Number: AT-E40049-T1. Title: Novel Chemical Entity. Filing Date: 2010-04-01. Inventors: Anderson, Robert, Davis, Linda. Abstract: The invention relates to a novel chemical entity with unique structural features and biological properties, suitable for development as a therapeutic ... IPC Classifications: A61K, A61L, A61F. This patent covers 30 claims related to 8 chemical compounds. Useful for intellectual property research, prior art searches, and chemical innovation tracking.
Compound 526388: 1,7-Dibromo,2,8-dichloro-dibenzo-dioxin

Chemical compound data from PubChem database. IUPAC Name: 1,7-dibromo-2,8-dichlorodibenzo-p-dioxin. Molecular Formula: C12H4Br2Cl2O2. Molecular Weight: 410.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Managed Care Institutional Provider Network Data: September 30, 2015

The primary purpose for the Provider Network Data System is to collect data needed to evaluate the provider networks including physicians, hospitals, labs, home health agencies, durable medical equipment providers, etc., for all types of Managed Care plans in New York State, including HIV Special Need Plans (SNP), Family Health Plus (FHP) Buy-In, Programs of All-Inclusive Care for the Elderly (PACE), and Non-PACE Managed Long-Term Care (MLTC) plans. This dataset reflects institutional provider data. Provider Network Data System information is self reported. For more information, go to http://www.health.ny.gov/health_care/managed_care/.
Patent AT-E401333-T1: [Translated] 1-OXA-3,9-DIAZASPIROC5.5ÜUNDECAN-2-ONE DERIVATIVES AND THEIR USE AS NEUROKININ RECEPTOR ANTAGONISTS

Chemical patent from PubChem database. Patent Number: AT-E401333-T1. Title: Novel Chemical Entity. Filing Date: 2012-11-25. Inventors: Patel, Amit, Jones, Michael. Abstract: The invention relates to a novel chemical entity with unique structural features and biological properties, suitable for development as a therapeutic ... IPC Classifications: C07D, C07F, A61K. This patent covers 13 claims related to 2 chemical compounds. Useful for intellectual property research, prior art searches, and chemical innovation tracking.
New York State Statewide Weekly COVID-19 Hospitalizations and Fatalities

This dataset includes information at the reporting facility level on weekly patients hospitalized and fatalities. Patient information collected as part of the HERDS Hospital Survey are lab-confirmed COVID-19 positive. Hospitalized means patients admitted as inpatients in either inpatient or observation beds and does not include patients that were treated and released from an Emergency Department.

This dataset began reporting on xx/xx/xx – COVID-19 hospitalization data prior to this date is available in this archived dataset: <a href=https://health.data.ny.gov/d/jw46-jpb7/>https://health.data.ny.gov/d/jw46-jpb7/</a>
Patent AT-E400962-T1: [Translated] EXCHANGE AND USE OF GLOBALLY UNIQUE DEVICE IDENTIFIERS FOR INTEGRATION OF CIRCUIT SWITCHING AND PACKET SWITCHING

A system and method of exchanging GRUUs (Globally Routed User Agent URI (Uniform Resource Identifier)) between a first telephony-enabled device and a second telephony enabled device using a circuit-switched message is provided. Once exchanged, the telephony enabled devices can exchange SIP (session initiated protocol) communications routed by the GRUUs. Any one of the telephony-enabled devices can add a media component to the SIP communications. Also a system and method of generating GRUUs is provided. According to another aspect, a system and method of handing off communications to a packet switched network from a circuit switched network is provided.
Compound 528667: Phenylethylmalonic acid, bis(trimethylsilyl) ester

Chemical compound data from PubChem database. IUPAC Name: bis(trimethylsilyl) 2-ethyl-2-phenylpropanedioate. Molecular Formula: C17H28O4Si2. Molecular Weight: 352.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 525570: N,N-Dimethyl-N'-(3-ethoxyphenyl)-p-chlorobenzamidine

Chemical compound data from PubChem database. IUPAC Name: 4-chloro-N'-(3-ethoxyphenyl)-N,N-dimethylbenzenecarboximidamide. Molecular Formula: C17H19ClN2O. Molecular Weight: 302.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 527310: Methyl 1,8-diethyl-1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetate

Chemical compound data from PubChem database. IUPAC Name: methyl 2-(1,8-diethyl-4,9-dihydro-3H-pyrano[3,4-b]indol-1-yl)acetate. Molecular Formula: C18H23NO3. Molecular Weight: 301.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Ondansetron hydrochloride

Ondansetron Hydrochloride is a prescription injectable medication used to prevent nausea and vomiting, often after chemotherapy or surgery. It works as a serotonin receptor antagonist and is administered via intramuscular or intravenous injection at a strength of 2 mg/mL. Manufactured by Fresenius Kabi USA, LLC, this preservative-free version is approved under ANDA076972. This information was generated using AI and is provided for informational and research purposes only.
Tribal Title IV-E Agency Requirements for Electing Title IV-E Prevention and Family Services and Programs

The purpose of this Program Instruction (PI) is to instruct tribal title IV-E agencies administering or supervising the administration of title IV-E under sections 479B and 471(a) of the Act on the title IV-E prevention program requirements, the exemption of tribal title IV-E agencies from the evaluation waiver and continuous quality improvement requirements, and on the flexibility title IV-E agencies may provide to tribes with whom they have agreements under section 472(a)(2)(B)(ii) of the Act. This PI supersedes ACF-ACYF-CB-PI-18-10 issued November 30, 2018, upon publication.

Metadata-only record linking to the original dataset. Open original dataset below.
Compound 529215: Ethyl 5-(sec-butylsulfanyl)-3-(4-chlorophenyl)-4-cyano-2-thiophenecarboxylate

Chemical compound data from PubChem database. IUPAC Name: tert-butyl-dimethyl-(4-methylcyclohexyl)oxysilane. Molecular Formula: C13H28OSi. Molecular Weight: 228.45. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Comparison Between 2018-2020 NSDUH Substate Region Estimates

Substate estimates for these years are no longer available due to methodological concerns with combining 2020 data with data from 2018 and 2019. We apologize for any inconvenience or confusion this may cause.Because of the COVID-19 pandemic, most respondents answered the survey via the web in Quarter 4 of 2020, even though all responses in Quarter 1 were from in-person interviews. It is known that people may respond to the survey differently while taking it online, thus introducing what is called a mode effect.When the state estimates were released, it was assumed that the mode effect was similar for different groups of people. However, later analyses have shown that this assumption should not be made. Because of these analyses, along with concerns about the rapid societal changes in 2020, it was determined that averages across the three years could be misleading.For more detail on this decision, see the 2018-2020substate data page.
Adult Care Facility Annual Survey: 2009-2012

<b>Note: This annual report is no longer updated. Beginning with the 1st QSIR 2017, these reports will be updated quarterly only. Please see the link in the featured content.</b> The Department of Health (NYSDOH) requires adult care facilities (ACFs) to complete an electronic filing of each facility's licensed adult home and enriched housing program bed census on an annual basis. These facilities include adult homes (AHs), enriched housing programs (EHPs), assisted living programs (ALPs), assisted living residences (ALRs), special needs assisted living residences (SNALR), and enhanced assisted living residences (EALR). Available bed and occupancy information in ACFs is self-reported and is not audited by NYSDOH. This dataset is refreshed on a annual basis. For more information, check out http://www.health.ny.gov/facilities/adult_care/.
Compound 529893: 4-(3-Hydroxypropyl)-2,6-Dimethoxyphenol

Chemical compound data from PubChem database. IUPAC Name: 4-(3-hydroxypropyl)-2,6-dimethoxyphenol. Molecular Formula: C11H16O4. Molecular Weight: 212.24. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
New York State  (Outside New York City)  COVID-19 Cases and Contacts Contact Tracing Initiative

<b>Note: This dataset is no longer updated.</b> This dataset includes cumulative and weekly counts of the number of new COVID-19 cases reported, number of cases reached, percent cases reached, total contacts elicited, total elicited contacts reached, and percent contacts reached by each week. Please note: In the earlier days of the program, the number of cases represented the numbers reported by selected LHDs. Therefore, the volume could be much lower than all new COVID cases.
Isosorbide mononitrate

Isosorbide Mononitrate is a prescription medication available as extended-release oral tablets in 30mg, 60mg, and 120mg strengths. Manufactured by Ingenus Pharmaceuticals, LLC, it belongs to the nitrate vasodilator class and works by promoting vasodilation to help manage conditions like angina. This information was generated using AI and is provided for informational and research purposes only.
Prenatal Alcohol and Other Drug Exposures in Child Welfare Study: Final Report

This report presents the results of a federally funded study that examined federal and State policies guiding child welfare prenatal substance exposure (PSE) identification and care, child welfare staff awareness and knowledge of PSE and practices to identify affected children and families, how PSE information is shared and documented, and how child welfare agencies interact with caregivers and allied service providers in supporting children and families. The study included interviews with child welfare directors and reviews of State policy documents pertaining to PSE in five States; interviews with child welfare staff and directors (n=171) at 22 agency sites, as well as a survey of allied PSE-relevant service providers (n=271), and a review of local agency-level policy documents; and in-depth interviews with 13 local agency data staff at two States, as well as a survey of 21 allied PSE-relevant service providers, focus groups or interviews with 48 caregivers, and a review of 212 local agency case files. Results from the study are reported and indicate: States reported policy revisions and enhanced collaborative partnerships in response to CAPTA/CARA legislation; defining prenatal exposure as child maltreatment may be a barrier to providing supportive services to families; most staff reported participating in training related to PSE and stated a high level of awareness about the effects of PSE, yet many displayed inaccurate knowledge about the effects of prenatal alcohol syndrome; staff reported inconsistent assessment for PSE; when PSE is a concern, most CW staff reported that they would refer to developmental and early intervention services along with medical providers; PSE information was not consistently located in a single report or location; and among the caregivers who had cared for a child with PSE, few reported that they were fully prepared to do so. Additional findings are reported and recommendations are made.

Metadata-only record linking to the original dataset. Open original dataset below.
Compound 526353: 3,6-Dibromo-dibenzofuran

Chemical compound data from PubChem database. IUPAC Name: 3,6-dibromodibenzofuran. Molecular Formula: C12H6Br2O. Molecular Weight: 325.98. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 526366: 4-Bromo-1,2,7,8-tetrachloro-dibenzo-p-dioxin

Chemical compound data from PubChem database. IUPAC Name: 4-bromo-1,2,7,8-tetrachlorodibenzo-p-dioxin. Molecular Formula: C12H3BrCl4O2. Molecular Weight: 400.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528655: Erythronic acid, tetra-TMS

Chemical compound data from PubChem database. IUPAC Name: trimethylsilyl 2,3,3-tris(trimethylsilyloxy)propanoate. Molecular Formula: C15H38O5Si4. Molecular Weight: 410.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 527397: 3-(Cyclohexen-1-yl)prop-2-enal

Chemical compound data from PubChem database. IUPAC Name: 3-(cyclohexen-1-yl)prop-2-enal. Molecular Formula: C9H12O. Molecular Weight: 136.19. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Leukocyte adhesion and recruitment, and alpha-1-antitrypsin deficiency: a report from ATS 2001, May 18-23, San Francisco

The program at this year's American Thoracic Society international conference included over 300 scientific and clinical symposia. In this report I have reviewed the data presented on two important areas of lung inflammation, namely leukocyte recruitment and alpha-1-antitrypsin deficiency. Highlights included work from a number of groups identifying the contribution of specific leukocyte adhesion molecules (CD18, CD11a and vascular cell adhesion molecule-1) which varied according to the site and nature of the initial inflammatory stimulus. In addition work was presented examining the contribution of various chemoattractants to the process of leukocyte recruitment in chronic obstructive pulmonary disease, with leukotriene B4 in particular appearing to play a major role. In alpha-1-antitrypsin deficiency other molecules may also be important and work was presented demonstrating the pro-inflammatory potential of alpha-1-antitrypsin polymers in the lungs of these patients. These advances in the understanding of the basic mechanisms of inflammation will, in the future, allow the development of novel anti-inflammatory therapies for a variety of lung diseases.
Compound 526438: 6,7,8,9-Tetrahydro-pyrido[2,1-b]quinazolin-11-one

Chemical compound data from PubChem database. IUPAC Name: 8-methylpyrido[2,1-b]quinazolin-11-one. Molecular Formula: C13H10N2O. Molecular Weight: 210.23. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Behavioral Health Barometer: District of Columbia, 2014

This is a behavioral health report for the state of District of Columbia. It uses the National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use, youth mental health and treatment, adult mental health and treatment, substance use, and substance use treatment for the years 2009 to 2013.
Compound 526258: 1,2,8,9-Tetrabromo-dibenzofuran

Chemical compound data from PubChem database. IUPAC Name: 1,2,8,9-tetrabromodibenzofuran. Molecular Formula: C12H4Br4O. Molecular Weight: 483.77. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.