AndreaBozzo/ceres-open-data-index huggingface dataset:
Compound 530423: Cyclopentanone, 2,3-dimethyl-

Chemical compound data from PubChem database. IUPAC Name: 2,3-dimethylcyclopentan-1-one. Molecular Formula: C7H12O. Molecular Weight: 112.17. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Predictors of refusal to participate: a longitudinal health survey of the elderly in Australia

Background
          The loss of participants in longitudinal studies due to non-contact, refusal or death can introduce bias into the results of such studies. The study described here examines reasons for refusal over three waves of a survey of persons aged ≥ 70 years.
        
        
          Methods
          In a longitudinal study involving three waves, participants were compared to those who refused to participate but allowed an informant to be interviewed and to those who refused any participation.
        
        
          Results
          At Wave 1 both groups of Wave 2 non-participants had reported lower occupational status and fewer years of education, had achieved lower verbal IQ scores and cognitive performance scores and experienced some distress from the interview. Those with an informant interview only were in poorer physical health than those who participated and those who refused. Depression and anxiety symptoms were not associated with non-participation. Multivariate analyses found that verbal IQ and cognitive impairment predicted refusal. Results were very similar for refusers at both Waves 2 and 3.
        
        
          Conclusions
          Longitudinal studies of the elderly may over estimate cognitive performance because of the greater refusal rate of those with poorer performance. However, there is no evidence of bias with respect to anxiety or depression.
The PEST sequence does not contribute to the stability of the cystic fibrosis transmembrane conductance regulator

Background
          Endoplasmic reticulum retention of misfolded cystic fibrosis transmembrane conductance regulator (CFTR) mutants and their rapid degradation is the major cause of cystic fibrosis (CF). An important goal is to understand the mechanism of how the misfolded proteins are recognized, retained, and targeted for degradation.
        
        
          Results
          Using a web-based algorithm, PESTFind, we found a PEST sequence in the regulatory (R) domain of CFTR. The PEST sequence is found in many short-lived eukaryotic proteins and plays a role in their degradation. To determine its role in the stability and degradation of misprocessed CFTR, we introduced a number of site-directed mutations into the PEST sequence in the cDNA of ΔF508 CFTR, the most prevalent misprocessed mutation found in CF patients. Analysis of these mutants showed that the disruption of the PEST sequence plays a minor role in the degradation of the CFTR mutants. Multiple mutations to the PEST sequence within the R domain of CFTR inhibit maturation of CFTR and prevent the formation of a 100 kDa degradation product. The mutations, however, do not improve the stability of the mutant ΔF508 CFTR.
        
        
          Conclusion
          These observations show that disruption of the structure of the R domain of CFTR can inhibit maturation of the protein and that the predicted PEST sequence plays no significant role in the degradation of CFTR.
Kansas (KS)

This report uses 2008 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past year alcohol use disorder and illicit drug use disorder among persons aged 12 or older for Kansas overall and for substate regions within Kansas. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE).
Patent AT-E400423-T1: [Translated] DEVICE FOR STACKING THERMOPLASTIC PARTS

The device has a connecting link (10) and an intake plate that comprises a retainer, where the intake plate is rotatable around 180 degrees. An actuator engages at an actuator point and is connected with a linear drive (7). The intake plate comprises a pivot bearing (9) whose axis coincides with the actuator point. A guiding pin is arranged between the tool and a stacking station and the connecting link comprises two linear sections (11) and a V-shaped section (12) between the two sections.
Emergency Temporary Shelters - Grievances Filed

Under <a href="https://chicityclerkelms.chicago.gov/Matter/?matterId=6DEAA6D8-D0E6-EE11-904C-001DD806E058" target="_blank">SO2024-0008386</a>, passed by City Council on 4/17/2024, the Department of Family and Support Services publishes data on the City-operated and City-funded emergency new arrivals shelters. This dataset shows grievances filed by migrants staying at the shelters, grouped by type and the two-week period filed.
Compound 527596: 4-Penten-1-ol, bromoacetate

Chemical compound data from PubChem database. IUPAC Name: pent-4-enyl 2-bromoacetate. Molecular Formula: C7H11BrO2. Molecular Weight: 207.06. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Child Maltreatment 2018

This report presents national data about child abuse and neglect known to child protective services agencies in the United States during federal fiscal year 2018.

Letter from the Associate Commissioner

Acknowledgements

Summary

Chapter 1: Introduction

Chapter 2: Reports

Chapter 3: Children

Chapter 4: Fatalities

Chapter 5: Perpetrators

Chapter 6: Services

Chapter 7: Special Focus

Appendix A: CAPTA Data Items

Appendix B: Glossary

Appendix C: State Characteristics

Appendix D: State Commentary

Metadata-only record linking to the original dataset. Open original dataset below.
Specificity of T cells in synovial fluid: high frequencies of
		  CD8

CD8+ T cells dominate the lymphocyte population in
synovial fluid in chronic inflammatory arthritis. It is known that these
CD8+ T cells are often clonally or oligoclonally expanded, but their
specificity and their relevance to the pathogenesis of joint disease has
remained unclear. We found that as many as 15.5% of synovial CD8+ T
cells may be specific for a single epitope from an Epstein-Barr virus lytic
cycle protein. The virus-specific T cells within the joint showed increased
expression of markers of activation and differentiation compared with those in
the periphery, and retained their functional capacity to secrete
proinflammatory cytokines on stimulation. These activated, virus-specific
CD8+ T cells could therefore interact with synoviocytes, either by
cell-cell contact or by a cytokine network, and play a 'bystander'
role in the maintenance of inflammation in patients with arthritis.
Glucosinolate breakdown products as insect fumigants and their effect on carbon dioxide emission of insects

Background
          Glucosinolate breakdown products are volatile, therefore good candidates for insect fumigants. However, although they are insecticidal, the mode of action of such natural products is not clear. We studied the insecticidal effect of these compounds as fumigants, and monitored the production of carbon dioxide by the insects as a probe to the understanding of their mode of action.
        
        
          Results
          The fumigation 24-h LC50 against the house fly (Musca domestica L.) of allyl thiocyanate, allyl isothiocyanate, allyl cyanide, and l-cyano-2-hydroxy-3-butene was 0.1, 0.13, 3.66, and 6.2 μg cm-3, respectively; they were 0.55, 1.57, 2.8, and > 19.60 μg cm-3, respectively, against the lesser grain borer (Rhyzopertha dominica Fabricius). The fumigation toxicity of some of the glucosinolate products was very close to or better than that of the commercial insect fumigants such as chloropicrin (LC50: 0.08 and 1.3 μg cm-3 against M. domestica and R. dominica, respectively) and dichlorovos (LC50: < 0.02 and 0.29 μg cm-3 against M. domestica and R. dominica, respectively) in our laboratory tests. Significantly increased CO2 expiration was found in insects exposed to the vapor of allyl isothiocyanate, allyl thiocyanate and allyl isocyanate. Allyl isothiocyanate was also found to increase the CO2 expiration of the American cockroach (Periplaneta americana L.).
        
        
          Conclusions
          Glucosinolate breakdown products have potential as biodegradable and safe insect fumigants. They may act on the insect respiratory system in their mode of action.
Debate: Subgroup analyses in clinical trials: fun to look at - but don't believe them!

Analysis of subgroup results in a clinical trial is surprisingly unreliable, even in a large trial. This is the result of a combination of reduced statistical power, increased variance and the play of chance. Reliance on such analyses is likely to be more erroneous, and hence harmful, than application of the overall proportional (or relative) result in the whole trial to the estimate of absolute risk in that subgroup. Plausible explanations can usually be found for effects that are, in reality, simply due to the play of chance. When clinicians believe such subgroup analyses, there is a real danger of harm to the individual patient.
Alcaftadine

Alcaftadine is an over-the-counter eye drop solution used to relieve itching and discomfort from eye allergies. It contains 0.25% alcaftadine, a histamine H1 receptor antagonist, and is applied directly to the eyes. Manufactured by Aurohealth LLC under FDA application ANDA210659, it was marketed starting June 2023 but is now discontinued. This information was generated using AI and is provided for informational and research purposes only.
Impaired Driving Death Rate, by Age and Sex, 2012 & 2014, Region 2 - New York

Rate of deaths by age/gender (per 100,000 population) for people killed in crashes involving a driver with BAC =>0.08%, 2012, 2014. 2012 Source: Fatality Analysis Reporting System (FARS). 2014 Source: National Highway Traffic Administration's (NHTSA) Fatality Analysis Reporting System (FARS), 2014 Annual Report File. Note: Blank cells indicate data are suppressed. Fatality rates based on fewer than 20 deaths are suppressed.
National Survey of Substance Abuse Treatment Services (N-SSATS): 2005 Data on Substance Abuse Treatment Facilities

This report presents results from the 2005 National Survey of Substance Abuse Treatment Services (N-SSATS), an annual census of facilities providing substance abuse treatment. Conducted by the Substance Abuse and Mental Health Services Administration (SAMHSA), the N-SSATS is designed to collect data on the location, characteristics, and use of alcoholism and drug abuse treatment facilities and services throughout the 50 states, the District of Columbia, and other U.S. jurisdictions.
TANF Work Participation Rates

The U.S. Department of Health and Human Services (HHS) issues TANF state work participation rates, which measure how well states engage families receiving assistance in certain work activities during a fiscal year. For work participation rate purposes, states include the 50 states, the District of Columbia, and the US territories of Guam, Puerto Rico and the Virgin Islands. A state must meet an overall (or “all families”) and a two-parent work participation requirement or face a potential financial penalty. 

<b>Units of Response: </b>TANF Recipients, Work-Eligible Individuals

<b>Type of Data: </b>Administrative

<b>Tribal Data: </b>Yes

<b>Periodicity: </b>Annual

<b>Demographic Indicators: </b>Not Applicable

<b>SORN: </b>https://www.federalregister.gov/documents/2015/04/02/2015-07440/privacy-act-of-1974-system-of-records-notice

<b>Data Use Agreement: </b>Unavailable

<b>Data Use Agreement Location: </b>Unavailable

<b>Granularity: </b>State

<b>Spatial: </b>United States

<b>Geocoding: </b>State
Patent AT-E401814-T1: [Translated] DEVICE FOR PREPARING HOT BEVERAGES

Equipment (10) for the preparation of a hot beverage comprising a boiler (10) capable of containing a liquid component of the beverage, for example water, a collection container (14) and means (22, 20, 28) defining a delivery path for the liquid component from the boiler to the collection container. The equipment also comprises valve means (40) located along the delivery path for the liquid component comprising a plug (44) which can move between a position in which the delivery path is closed and one in which it is open and means (70, 72; 74, 76; 78) to immobilise the plug in the open position. These means are arranged in such a way that they can be activated and deactivated by a force exerted in the direction of movement of the plug.
Compound 526256: 1,2,7-Tribromo-4,9-dichloro-dibenzo-p-dioxin

Chemical compound data from PubChem database. IUPAC Name: 1,2,7-tribromo-4,9-dichlorodibenzo-p-dioxin. Molecular Formula: C12H3Br3Cl2O2. Molecular Weight: 489.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Response of regional brain glutamate transaminases of rat to aluminum in protein malnutrition

Background
          The mechanism of aluminum-induced neurotoxicity is not clear. The involvement of glutamate in the aluminium-induced neurocomplications has been suggested. Brain glutamate levels also found to be altered in protein malnutrition. Alterations in glutamate levels as well as glutamate-α-decarboxylase in different regions of rat brain has been reported in response to aluminum exposure. Thus the study of glutamate metabolising enzymes in different brain regions of rats maintained on either normal or restricted protein diet may be of importance for understanding the neurotoxicity properties of aluminium.
        
        
          Results
          Dietary protein restrictions does not have an significant impact on regional aluminum content of the brain. The interaction of aluminum intoxication and protein restriction is significant in the thalamic area and the midbrain-hippocampal region in cases of glutamate oxaloacetate transaminase. In the case of gluatmate pyruvate transaminase, this interaction is significant only in thalamic area.
        
        
          Conclusion
          The metabolism of amino acids, as indicated by activities of specific transaminases, of brain is altered in response to aluminum exposure. These alterations are region specific and are dependent on dietary protein intake or manipulation of the brain amino acid homeostasis.
Compound 528852: Disulfide, methyl 1-(1-propenylthio)propyl

Chemical compound data from PubChem database. IUPAC Name: 1-(methyldisulfanyl)-1-prop-1-enylsulfanylpropane. Molecular Formula: C7H14S3. Molecular Weight: 194.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Lisinopril and hydrochlorothiazide

Lisinopril and Hydrochlorothiazide is a prescription medication combining an ACE inhibitor and a diuretic to treat high blood pressure. Available as oral tablets in strengths like 10mg/12.5mg or 20mg/25mg, it's manufactured by Lupin Pharmaceuticals under ANDA 077912. This information was generated using AI and is provided for informational and research purposes only.
Patent AT-E399639-T1: [Translated] POLYESTER AND POLYAMIDE BLEND FOR CARBON DIOXIDE DEVELOPING FOOD

A packaged article, especially a respiring foodstuff such as cheese which generates or releases gas during storage, and a permeable multilayer heat sealable film having a high permeability to CO 2  and low O 2  permeability suitable for allowing escape of such gas while minimizing transfer of oxygen across the film which has a blend of polyester and nylon MXD6 is used to package cheese.
The immunological effects of continuous veno-venous haemodiafiltration
		  in critically ill patients

Background:
          Haemodynamic instability is common in septic patients with acute
				renal failure. Continuous veno-venous haemodiafiltration (CVVHD) is therefore
				used as an alternative to conventional haemodialysis. Haemodialysis is
				associated with an activation of the immune system. The aim of the present
				study was to test the hypothesis that initiation of CVVHD influences the immune
				system with release of proinflammatory cytokines followed by a decrease in
				granulocyte activation, as assessed by the expression of adhesion
				molecules.
        
        
          Results:
          Fifteen patients were included. Mean Acute Physiology and Chronic
				Health Evaluation-2 score before CVVHD was 19 (range 8⌓27). Mean duration of
				CVVHD treatment was 9 days (1⌓21 days). Tumour necrosis factor-α and
				interleukin-8 were detectable in plasma in all patients, whereas interleukin-10
				was detectable only in a few patients. Proinflammatory and anti-inflammatory
				cytokines were detected in the ultrafiltrate. Large intraindividual and
				interindividual variations were demonstrated for all of the immunological
				parameters studied.
        
        
          Conclusion:
          The hypothesis that CVVHD induces the release of proinflammatory
				cytokines followed by a decrease in granulocyte activation was not confirmed in
				the present study. The heterogeneous group of patients studied, with different
				underlying diseases and various durations of illness before the start of CVVHD,
				might have contributed to the difficulty in demonstrating the proposed
				immunological effect of CVVHD.
Patent AT-E400536-T1: [Translated] MAGNETIC FERRITE MATERIAL

The present invention provides a ferrite magnetic material capable of attaining such magnetic properties that Br + (1/3) HcJ is 6200 or more even by sintering at a temperature of 1150°C or lower. The ferrite magnetic material includes as a main phase thereof a ferrite phase having a hexagonal structure, the main phase being represented by the following composition formula (1) : La x Ca m ± 1-x-m  (Fe 12-y CO y ) z  with ±, representing one or two of Ba and Sr; wherein the constituent ratios of the metal elements constituting the main phase satisfy the following conditions: x and m are the values in a region bounded by the points, A:(0.53, 0.27), B: (0.64, 0.27), C:(0.64, 0.35), D:(0.53, 0.45), E:(0.47, 0.45) and F: (0.47, 0.32) in the (x, m) coordinates shown in FIG. 2; 1.3   x/yz   1.8; and 9.5   12z   11.0.
End date for the flexibilities extended in response to the COVID-19 pandemic under the Robert T. Stafford Disaster Relief and Emergency Assistance Act (Stafford Act) for requirements under titles IV-B and IV-E of the Act

This Information Memorandum (IM) informs title IV-B and IV-E agencies that the Stafford Act flexibilities offered by the Children’s Bureau in response to the COVID-19 pandemic disaster declarations will expire June 30, 2023.

Metadata-only record linking to the original dataset. Open original dataset below.
Compound 526350: 3,4,9-Tribromo-dibenzofuran

Chemical compound data from PubChem database. IUPAC Name: 1,6,7-tribromodibenzofuran. Molecular Formula: C12H5Br3O. Molecular Weight: 404.88. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 527236: 2,6,6-Trimethyltricyclo[6.2.1.01,5]undecane-7-carbaldehyde

Chemical compound data from PubChem database. IUPAC Name: 2,6,6-trimethyltricyclo[6.2.1.01,5]undecane-7-carbaldehyde. Molecular Formula: C15H24O. Molecular Weight: 220.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E400639-T1: [Translated] STABILIZED LIQUID COMPOSITIONS

Structuring systems, specifically thread-like structuring systems and/or disk-like structuring systems wherein structuring agents aggregate together to form disk-like structures that can interact with other disk-like structures to result in a structuring system, and processes for making such structuring systems, stabilized liquid compositions comprising such structuring systems, systems that utilize such structuring systems for stabilizing liquid compositions, and methods for utilizing the stabilized liquid compositions to provide a benefit, are disclosed.
NSDUH 2023 Screening Specifications

Browse the screening questionnaire used to determine respondent eligibility for the full 2023 National Survey on Drug Use and Health (NSDUH) interview. The documents include the exact questions as they appear in the screener, along with the skip patterns that determined whether a person was asked a question or not. There are two versions available – one for in-person screenings and another for web screenings. Both include English and Spanish language questions.
Atlanta-Sandy Springs-Marietta, GA

This report presents combined 2005 to 2010 National Survey on Drug Use and Health (NSDUH) results for those aged 12 or older in the Atlanta-Sandy Springs-Marietta, Georgia metro area. The report includes estimates of substance use disorder, major depressive episode, illicit drug use, marijuana use, cigarette use, binge alcohol use, and the nonmedical use of prescription-type pain relievers. Results are provided for Atlanta-Sandy Springs-Marietta, Georgia, and the U.S. overall.
Compound 529359: Cys isoBOC TBDMS

Chemical compound data from PubChem database. IUPAC Name: [tert-butyl(dimethyl)silyl] 2-(2-methylpropoxycarbonylamino)-3-(2-methylpropoxycarbonylsulfanyl)propanoate. Molecular Formula: C19H37NO6SSi. Molecular Weight: 435.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Risk and Protective Factors Tables (Prevalence Estimates) - 3.1 to 3.25

These detailed tables present totals and prevalence estimates of risk and protective factors regarding substance use from the 2011 National Survey on Drug Use and Health (NSDUH). The factors include perceptions of 1) risk of substance use, 2) availability of substances, 3) parental disapproval of youth substance use, 4) peer substance use. They also include measures of delinquent behavior, religious involvement, exposure to prevention messages, and parental involvement. Results are provided by age group, gender, race/ethnicity, geographic area, and youth substance use behavior. Comparisons are made between 2011 and 2010.
Olopatadine hydrochloride

Olopatadine Hydrochloride is an over-the-counter eye drop solution used to relieve itching and redness caused by allergic conjunctivitis (eye allergies). It works as an antihistamine and mast cell stabilizer. Available in a 5 mL bottle at 0.1% strength, manufactured by Rising Pharma Holdings, Inc. This information was generated using AI and is provided for informational and research purposes only.
Compound 527851: 2,4-Dichlorobenzyl propyl ether

Chemical compound data from PubChem database. IUPAC Name: 2,4-dichloro-1-(propoxymethyl)benzene. Molecular Formula: C10H12Cl2O. Molecular Weight: 219.1. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.