AndreaBozzo/ceres-open-data-index huggingface dataset:
Combined antibiotic and free radical trap treatment is effective at combating

Although early antibiotic treatment of patients with septic arthritis eradicates bacteria, joint destruction commonly results from the unregulated host inflammatory responses to infection. The spin trap compound phenyl-N-tert-butyl nitrone (PBN) has been shown to have both anti-inflammatory and antioxidant effects. The aim of this study was to assess the effect of combined systemic administration of PBN and cloxacillin on the development of Staphylococcus aureus arthritis.
        Three days after Naval Medical Research Institute (NMRI) mice were infected intravenously with S. aureus LS-1, daily treatment was started with cloxacillin alone, PBN alone, or cloxacillin and PBN. Arthritis, weight loss and general condition were evaluated for each mouse, and joints were analyzed histopathologically. Systemic administration of PBN in conjunction with cloxacillin ameliorated the course of experimental S. aureus arthritis, as evidenced by an increased cure rate. Thus, combinatorial antioxidant plus antibiotic anti-inflammatory therapies represent a potentially efficacious approach to the management of septic arthritis.
Compound 528694: 1-Methyl-2-(1-methylpropyl)benzene

Chemical compound data from PubChem database. IUPAC Name: 1-butan-2-yl-2-methylbenzene. Molecular Formula: C11H16. Molecular Weight: 148.24. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset

An inception cohort of 238 patients having peripheral joint synovitis of less than 12 months duration was evaluated clinically and followed prospectively for 1 year to determine the clinical significance of a number of rheumatoid arthritis (RA) associated autoantibodies. Serum samples collected at the time of the initial evaluation were tested for rheumatoid factor (RF) and antibodies to Sa (anti-Sa), RA-33, (pro)filaggrin [antifilaggrin antibody (AFA)], cyclic citrullinated peptide (anti-CCP), calpastatin, and keratin [antikeratin antibody (AKA)]. RF had a sensitivity of 66% and a specificity of 87% for RA. Anti-Sa, AFA, and anti-CCP all had a specificity of more than 90%, but a sensitivity of less than 50% for this diagnosis. Overall, there was a high degree of correlation between AFA, AKA, anti-Sa or anti-CCP, this being highest between anti-Sa and anti-CCP (odds ratio, 13.3; P < 0.001). Of the 101 patients who were positive for at least one of these four autoantibodies, 57% were positive for only one. Finally, anti-SA identified a subset of predominantly male RA patients with severe, erosive disease. Anti-SA, AFA and anti-CCP are all specific for early RA but, overall, have little additional diagnostic value over RF alone. Although these antibodies may preferentially recognize citrullinated antigens, the modest degree of concordance between them in individual patient sera suggests that it is unlikely a single antigen is involved in generating these responses.
Sequence requirements for RNA strand transfer during nidovirus discontinuous subgenomic RNA synthesis

Nidovirus subgenomic mRNAs contain a leader sequence derived from the 5′ end of the genome fused to different sequences (‘bodies’) derived from the 3′ end. Their generation involves a unique mechanism of discontinuous subgenomic RNA synthesis that resembles copy-choice RNA recombination. During this process, the nascent RNA strand is transferred from one site in the template to another, during either plus or minus strand synthesis, to yield subgenomic RNA molecules. Central to this process are transcription-regulating sequences (TRSs), which are present at both template sites and ensure the fidelity of strand transfer. Here we present results of a comprehensive co-variation mutagenesis study of equine arteritis virus TRSs, demonstrating that discontinuous RNA synthesis depends not only on base pairing between sense leader TRS and antisense body TRS, but also on the primary sequence of the body TRS. While the leader TRS merely plays a targeting role for strand transfer, the body TRS fulfils multiple functions. The sequences of mRNA leader–body junctions of TRS mutants strongly suggested that the discontinuous step occurs during minus strand synthesis.
Compound 528293: Benzene, 1,2,5-trimethyl-3-propyl

Chemical compound data from PubChem database. IUPAC Name: 1,2,5-trimethyl-3-propylbenzene. Molecular Formula: C12H18. Molecular Weight: 162.27. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
NCHS Research and Development Survey (RANDS) Round 9 Restricted File

The Research and Development Survey (RANDS) is a series of cross-sectional surveys using probability-sampled commercial survey panels. Some rounds also include non-probability panels. The ninth round of RANDS (RANDS 9) was administered by NORC at the University of Chicago using the AmeriSpeak Panel. A sample also was purchased by NORC from the Lucid non-probability panel. Data were collected from November 28, 2023 to January 12, 2024. RANDS 9 contained the embedded probe questions and experiments as in previous rounds of RANDS. It included questions on race-ethnicity demographic question response order, intimate partner violence, diabetes and obesity stigma, discrimination, and learning difficulty. The AmeriSpeak part of RANDS 9 has a known survey sampling design and can be used to produce nationally and sub-nationally representative estimates.
Compound 525355: 2,2-Dimethyl-4,5-dithiaoctane

Chemical compound data from PubChem database. IUPAC Name: 2,2-dimethyl-1-(propyldisulfanyl)propane. Molecular Formula: C8H18S2. Molecular Weight: 178.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Managed Care Individual Provider Network Data: December 31, 2014

The primary purpose for the Provider Network Data System is to collect data needed to evaluate the provider networks including physicians, hospitals, labs, home health agencies, durable medical equipment providers, etc., for all types of Managed Care plans in New York State, including HIV Special Need Plans (SNP), Family Health Plus (FHP) Buy-In, Programs of All-Inclusive Care for the Elderly (PACE), and Non-PACE Managed Long-Term Care (MLTC) plans. This dataset reflects individual provider data. Provider Network Data System information is self-reported. For more information, check out http://www.health.ny.gov/health_care/managed_care/.
2015 CMHS Uniform Reporting System (URS) Table for New Hampshire

2015 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for New Hampshire.  The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
Blood borne transit of CJD from brain to gut at early stages of infection

Background
          In Creutzfeldt-Jakob disease (CJD) and other related transmissible spongiform encephalopathies it is critical to understand the various pathways by which the infectious agent spreads to different organs.
        
        
          Methods
          We injected a CJD agent into mice, either intracerebrally (ic) or intraperitoneally (ip) and monitored the progressive appearance of abnormal PrP in peripheral tissues over time.
        
        
          Results
          Abnormal PrP was detected in lymphoreticular tissues of the gastrointestinal tract as early as 28 to 32 days after infection by both routes. This change persisted until the terminal stages of disease. In contrast, abnormal PrP was not detected in brain or spinal cord until 80 to 120 days after ic inoculation, or until 170 days after ip inoculation.
        
        
          Conclusions
          Brain lacks significant lymphatic drainage, and has little infectivity before 40 days, even after ic inoculation. Thus the infectious inoculum must spread to the gut by a vascular route, a direction opposite to that generally assumed. This interpretation is consistent with previous studies demonstrating white blood cell infectivity as well as perivascular PrP accumulations in CJD. Notably, enteric infection at early as well as later stages of disease, and regardless of the route of agent entry, implicates potential environmental spread by fecal matter.
Patent AT-E401174-T1: [Translated] RAZOR BLADE UNIT OF A SAFETY RAZOR

Chemical patent from PubChem database. Patent Number: AT-E401174-T1. Title: Process for Preparing Therapeutic Agents. Filing Date: 1992-01-26. Inventors: Smith, John A., Johnson, Mary B.. Abstract: A process for preparing therapeutic agents is described, involving multiple synthetic steps with optimized reaction conditions. The process enables la... IPC Classifications: C07C, C07B, A61K. This patent covers 33 claims related to 4 chemical compounds. Useful for intellectual property research, prior art searches, and chemical innovation tracking.
Patent AT-E401103-T1: [Translated] DEVICE FOR REGULATING THE FLOW RATE OF AN INTRAVENOUS MEDICAL SOLUTION DURING INJECTION

The object of this invention is to provide a device for regulating the flow rate of an intravenous medical solution during an injection using an intravenous drip unit. The device has a housing ( 10 ) mounted to a hose ( 300 ) to allow the flow of the solution from a solution container ( 200 ) into the vein, and a control member ( 20 ) rotatably assembled with the housing to regulate the flow rate of the solution. The housing has first and second seats ( 11, 12 ) communicating with inlet and outlet ports, and the control member has first and second bosses ( 21, 22 ) seated in the first and second seats. An arc-shaped solution path ( 23 ), a radial channel ( 24 ) and an annular groove ( 25 ) are formed on the control member to regulate the flow rate of the solution in accordance with an adjusted angle of the control member relative to the fixed housing.
Compound 525651: N,N-Dimethyl-N'-propyl-p-methoxybenzamidine

Chemical compound data from PubChem database. IUPAC Name: 4-methoxy-N,N-dimethyl-N'-propylbenzenecarboximidamide. Molecular Formula: C13H20N2O. Molecular Weight: 220.31. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
NNDSS - TABLE 1NN. Viral hemorrhagic fevers, Junin virus to Viral hemorrhagic fevers, Lujo virus

NNDSS - TABLE 1NN. Viral hemorrhagic fevers, Junin virus to Viral hemorrhagic fevers, Lujo virus - 2019. In this Table, provisional cases* of notifiable diseases are displayed for United States, U.S. territories, and Non-U.S. residents. 

Note: 
This table contains provisional cases of national notifiable diseases from the National Notifiable Diseases Surveillance System (NNDSS). NNDSS data from the 50 states, New York City, the District of Columbia and the U.S. territories are collated and published weekly on the NNDSS Data and Statistics web page (https://wwwn.cdc.gov/nndss/data-and-statistics.html). Cases reported by state health departments to CDC for weekly publication are provisional because of the time needed to complete case follow-up. Therefore, numbers presented in later weeks may reflect changes made to these counts as additional information becomes available. The national surveillance case definitions used to define a case are available on the NNDSS web site at https://wwwn.cdc.gov/nndss/. Information about the weekly provisional data and guides to interpreting data are available at: https://wwwn.cdc.gov/nndss/infectious-tables.html. 

Footnotes:
U: Unavailable — The reporting jurisdiction was unable to send the data to CDC or CDC was unable to process the data.
-: No reported cases — The reporting jurisdiction did not submit any cases to CDC.
N: Not reportable — The disease or condition was not reportable by law, statute, or regulation in the reporting jurisdiction.
NN: Not nationally notifiable — This condition was not designated as being nationally notifiable.
NP: Nationally notifiable but not published — CDC does not have data because of changes in how conditions are categorized.
Cum: Cumulative year-to-date counts.
Max: Maximum — Maximum case count during the previous 52 weeks.
* Case counts for reporting years 2018 and 2019 are provisional and subject to change. Cases are assigned to the reporting jurisdiction submitting the case to NNDSS, if the case's country of usual residence is the US, a US territory, unknown, or null (i.e. country not reported); otherwise, the case is assigned to the 'Non-US Residents' category. For further information on interpretation of these data, see https://wwwn.cdc.gov/nndss/document/Users_guide_WONDER_tables_cleared_final.pdf. 
† Previous 52 week maximum and cumulative YTD are determined from periods of time when the condition was reportable in the jurisdiction (i.e., may be less than 52 weeks of data or incomplete YTD data). 
§ Prior to 2015, CDC's National Notifiable Diseases Surveillance System (NNDSS) did not receive electronic data about incident cases of specific viral hemorrhagic fevers; instead data were collected in aggregate as "viral hemorrhagic fevers'. NNDSS was updated beginning in 2015 to receive data for each of the viral hemorrhagic fevers listed.
Compound 527987: Octanoic acid, 2-chloro-1-(chloromethyl)ethyl ester

Chemical compound data from PubChem database. IUPAC Name: 1,3-dichloropropan-2-yl octanoate. Molecular Formula: C11H20Cl2O2. Molecular Weight: 255.18. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Weekly Differences in Cumulative Influenza Vaccination Coverage and Comparison Between 2024-25 and 2023-24 Among Adults 18 Years, Overall, by Selected Demographics

• Weekly Influenza Vaccination Coverage and Comparison among adults 18 Years and Older by Jurisdiction

 • Weekly estimates of influenza vaccination coverage and intent for vaccination among adults are calculated using data from the National Immunization Survey–Adult COVID Module (NIS–ACM) (https://www.cdc.gov/nis/about/).
Compound 530755: o-Methoxybenzoic acid, 5-fluoro-2-nitrophenyl ester

Chemical compound data from PubChem database. IUPAC Name: (5-fluoro-2-nitrophenyl) 2-methoxybenzoate. Molecular Formula: C14H10FNO5. Molecular Weight: 291.23. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 64960: 1,5-Anhydroglucitol

Chemical compound data from PubChem database. IUPAC Name: (2R,3S,4R,5S)-2-(hydroxymethyl)oxane-3,4,5-triol. Molecular Formula: C6H12O5. Molecular Weight: 164.16. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528102: Decyl 3,5-dinitrobenzoate

Chemical compound data from PubChem database. IUPAC Name: decyl 3,5-dinitrobenzoate. Molecular Formula: C17H24N2O6. Molecular Weight: 352.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
2012 Uniform Reporting System (URS) Tables for Virgin Islands

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2012. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
Patent AT-E401619-T1: [Translated] METHOD FOR INTERFERENCE-FREE IMAGE CAPTURE USING AN ELECTRONIC SENSOR

A method of noise-free image acquisition by means of an electronic sensor, in which an image being detected is continuously contacted more strongly to the sensor, while a sequence of images is received by the means of the sensor. An image is selected from the sequence, according to specified criteria, as an output image (Bt). At least one further image is chosen from the sequence as a correction image (Bs) or is used for determining a correction image and the output image is corrected by subtracting the correction image.
Compound 525494: 5-Methyl-3-thiadecane

Chemical compound data from PubChem database. IUPAC Name: 1-ethylsulfanyl-2-methylheptane. Molecular Formula: C10H22S. Molecular Weight: 174.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E400649-T1: [Translated] NEW METHOD FOR INDUCING CELLULAR SENSENCE AND SCREENING METHOD FOR AN ANTI-AGING AGENT

Transformed cells obtained by transferring into normal cells with a gene encoding a protein capable of phosphorylation of p38 protein, or the p38 protein, a variant of the p38 protein, the kinase domain of the p38 protein, the kinase domain of p38 protein variant or a fused protein containing any of them, are new. Independent claims are also included for: (1) screening compounds using normal cells transferred with a gene to induce normal aging cells or cell aging comprising: (a) contacting with a test substance; and (b) analysis of an aging indication in cells; (2) anti-aging agents thus screened; and (3) anti-aging drug compositions containing the screened compounds which are inhibitors of the p38 protein, or a molecule located downstream of p38 in the p38 MAPK pathway or its fused protein. ACTIVITY : Anti-aging. No biological data is given. MECHANISM OF ACTION : None given.
Patent AT-E401342-T1: [Translated] METHODS AND MATERIALS FOR DETECTING AND MEASURING DAMAGE CAUSED BY FREE RADICALS

The present invention teaches a marker useful for detection and measurement of free radical damage. Specifically, the invention takes advantage of alterations which occur to the N-terminus of the albumin molecule, a circulating protein in human blood, in the presence of free radicals. These alterations effect the ability of the N-terminus of the albumin molecule to bind metals. Methods for detecting and quantifying this alteration include evaluating and quantifying the cobalt binding capacity of an albumin-containing sample, analysis and measurement of the ability of albumin to bind exogenous cobalt, detection and measurement of the presence of copper in a purified albumin sample and use of an immunological assay specific to the altered form of serum albumin which occurs following free radical damage. Also taught by the present invention is the use of the peptide Asp Ala His Lys and the compound Asp-Ala-His-Lys-R, wherein R is any chemical group capable of producing a detectable signal when a metal ion capable of binding to the N-terminus of naturally-occurring albumin is bound to the compound, for detection and quantitation of the marker. Methods of the present invention also include use of the marker as a "biochemical tag", thereby allowing for sensitive detection and measurement of the efficacy of clinical drugs and therapeutics which result in the generation of free radicals or which act to limit free radical damage. The marker also acts as a "biological tag" of a process implicated in a wide array of diseases and conditions and, accordingly, may be used to monitor and assess such diseases and conditions. Finally, the invention provides antibodies, immunoassays, and kits for use in detecting or quantitating the marker.
Compound 529074: 1H-Pyrrole, 1-methyl-2-pentyl

Chemical compound data from PubChem database. IUPAC Name: 1-methyl-2-pentylpyrrole. Molecular Formula: C10H17N. Molecular Weight: 151.25. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Synthesis and cytotoxicity of a biotinylated CC-1065 analogue

Background
          The use of pretargeting technology for cancer imaging and treatment has made significant progress in the last few years. This approach takes advantage of the fact that biotin binds strongly to proteins avidin and streptavidin. Thus, a non-toxic tumor cell specific antibody is conjugated with avidin/streptavidin, and is administered to patients. After the antibody binds to tumor cells (usually 24–48 h); a clearing agent is given to remove the residual circulating antibodies in blood. Lastly, a toxic biotin-radioisotope conjugate is administered. Due to the small size of the biotin-radioisotope molecule and tight binding between biotin and avidin/streptavidin, the biotin-radioisotope rapidly binds to tumor cells with high specificity. CC-1065 (1) is one of a few classes of extremely potent antitumor agents, and a biotinalyted CBI-bearing CC-1065 analogue is a promising candidate to be used in the pretargeting technology to treat cancer.
        
        
          Results
          A biotinalyted CBI-bearing CC-1065 analogue, 6, was synthesized. The IC50 of 6 was 0.7 nM against U937 cells. Compound 6 caused apototsis of U937 cells.
        
        
          Conclusions
          For the first time, a biotinalyted CBI-bearing CC-1065 analogue, 6, was synthesized. The biotinylated 6 can serve as a model compound to explore the usefulness of non-radioactive small molecule anticancer drugs in the pretargeting strategy for cancer imaging and therapy.
Compound 525678: p-Chlorobenzylidene-(3-ethoxyphenyl)-amine

Chemical compound data from PubChem database. IUPAC Name: 1-(4-chlorophenyl)-N-(3-ethoxyphenyl)methanimine. Molecular Formula: C15H14ClNO. Molecular Weight: 259.73. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
National Directory of Drug and Alcohol Abuse Treatment Facilities - 1989

The National Directory of Drug and Alcohol Abuse Treatment Programs 1989 lists federal, state, local, and private facilities that provide substance abuse treatment services. The directory includes treatment facilities that are licensed, certified, or otherwise approved for inclusion in the directory by their state substance abuse agencies and that responded to the 1988 National Survey of Substance Abuse Treatment Services (N-SSATS). The information about each facility that appears in this directory was provided by that facility in response to the 1988 N-SSATS. The Substance Abuse and Mental Health Services Administration (SAMHSA) conducts the N-SSATS annually.
Northeast: 2011-2012 NSDUH

This report presents the Northeast\'s (e.g., combines Connecticut, Maine, Massachusetts, New Hampshire, New Jersey, New York, Pennsylvania, Rhode Island, and Vermont) estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for the Northeast for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.