AndreaBozzo/ceres-open-data-index huggingface dataset:
Live Births with Low and Very Low Birthweight

This dataset contains tables with the percent of live births with low birthweight and very low birthweight: 1) by maternal county of residence 2) by race/ethnicity group of mother. Low birthweight are live births weighing less than 2,500 grams (approximately 5 pounds, 8 ounces). Very low birthweight are live births weighing less than 1,500 grams (approximately 3 pounds, 5 ounces). Low and very low birthweight can be associated with very serious health problems for the infant and can lead to certain serious health conditions later in life. Data includes births with birthweight of 227 to 8,165 grams and excludes non-California residents.
Compound 525802: N-(4-Methylphenyl)-N'-(4-bromophenyl)formamidine

Chemical compound data from PubChem database. IUPAC Name: N-(4-bromophenyl)-N'-(4-methylphenyl)methanimidamide. Molecular Formula: C14H13BrN2. Molecular Weight: 289.17. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 529049: 1,2,4-Trithiolane, 3,5-bis(1-methylethyl)-

Chemical compound data from PubChem database. IUPAC Name: 3,5-di(propan-2-yl)-1,2,4-trithiolane. Molecular Formula: C8H16S3. Molecular Weight: 208.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
MCMV induces neointima in IFN-γR-/- mice: Intimal cell apoptosis and persistent proliferation of myofibroblasts

Background
          CMV infections have been linked to vasculopathies like atherosclerosis and Scleroderma. CMV infects vascular endothelium with intermittent shedding of the virus and the development of latency.
        
        
          Methods
          We adopted a model of arteritis, developed by Presti et al. (1998), triggered by murine cytomegalovirus (MCMV) infection. Our studies focused on neointima formation. Groups of mice include: 1) immunocompetent 129S, 2) immunocompetent 129S receiving whole body irradiation and MCMV, 3) IFN-γR-/- receiving MCMV, and 4) IFN-γR-/- receiving MCMV and whole body irradiation.
        
        
          Results
          Mice were inoculated with MCMV (5 x 104 or 1 x 105 PFU's) by i.p. injection; hearts and abdominal aortas were collected and histopathology evaluated. Infected immunocompetent animals exhibited widespread perivascular inflammation, which subsided by 8 weeks. Intimal pathology was not observed in any control group. Immunocompetent animals receiving MCMV and irradiation developed mild to moderate intimal lesions associated with medial and adventitial inflammation. IFN-γR-/- mice infected for 4 months and receiving whole body irradiation 2 months after infection developed pathology characterized by extensive adventitial and medial infiltrate and significant neointima, suggesting that infection and immunosuppression were co-requisites of neointima formation. Immunohistochemical analysis revealed myofibroblasts as a major component of neointima. The disease is characterized by up-regulation of growth factors (TGF-β1, PDGF-A and B). Apoptosis was detected in the intimal layer of affected aortas. Active proliferation of myofibroblasts and infiltrating cells was also detected.
        
        
          Conclusion
          These results indicate that CMV infections may lead to intimal injury that results in the formation of neointima characteristic of autoimmune vasculopathies.
The role of chlorophyll

Background
          The physico-chemical properties of chlorophylls b and c have been known for decades. Yet the mechanisms by which these secondary chlorophylls support assembly and accumulation of light-harvesting complexes in vivo have not been resolved.
        
        
          Presentation
          Biosynthetic modifications that introduce electronegative groups on the periphery of the chlorophyll molecule withdraw electrons from the pyrrole nitrogens and thus reduce their basicity. Consequently, the tendency of the central Mg to form coordination bonds with electron pairs in exogenous ligands, a reflection of its Lewis acid properties, is increased. Our hypothesis states that the stronger coordination bonds between the Mg atom in chlorophyll b and chlorophyll c and amino acid sidechain ligands in chlorophyll a/b- and a/c-binding apoproteins, respectively, enhance their import into the chloroplast and assembly of light-harvesting complexes.
        
        
          Testing
          Several apoproteins of light-harvesting complexes, in particular, the major protein Lhcb1, are not detectable in leaves of chlorophyll b-less plants. A direct test of the hypothesis – with positive selection – is expression, in mutant plants that synthesize only chlorophyll a, of forms of Lhcb1 in which weak ligands are replaced with stronger Lewis bases.
        
        
          Implications
          The mechanistic explanation for the effects of deficiencies in chlorophyll b or c points to the need for further research on manipulation of coordination bonds between these chlorophylls and chlorophyll-binding proteins. Understanding these interactions will possibly lead to engineering plants to expand their light-harvesting antenna and ultimately their productivity.
Successful immunotherapy with matrix metalloproteinase-derived peptides in adjuvant arthritis depends on the timing of peptide administration

We have recently found that matrix metalloproteinases (MMPs) are targets for T-cell and B-cell reactivity in experimental arthritis. In the present article, we investigate whether modulation of MMP-specific T-cell responses could influence the course of adjuvant arthritis (AA). Lewis rats were treated nasally with MMP peptides prior to or after AA induction. Administration of the MMP-10 or the MMP-16 peptide prior to AA induction reduced the arthritic symptoms. In contrast, administration of the MMP-10 peptide after AA induction aggravated the arthritic symptoms. The present study shows the possible usefulness of MMP peptides for immunotherapy. However, a clear understanding of proper timing of peptide administration is crucial for the development of such therapies.
2013 NSDUH Risk and Protective Factors Tables  (Prevalence Estimates) - 3.1 to 3.25

These detailed tables present totals and prevalence estimates of risk and protective factors regarding substance use from the 2013 National Survey on Drug Use and Health (NSDUH). The factors include perceptions of 1) risk of substance use, 2) availability of substances, 3) parental disapproval of youth substance use, 4) peer substance use. They also include measures of delinquent behavior, religious involvement, exposure to prevention messages, and parental involvement. Results are provided by age group, gender, race/ethnicity, geographic area, and youth substance use behavior. Comparisons are made between 2013 and 2012.
Lomustine

Gleostine (lomustine) is an oral prescription medication used as a chemotherapy drug to treat certain cancers, such as brain tumors. It works by interfering with cancer cell growth through alkylating activity. Available as capsules in strengths of 10mg, 40mg, and 100mg, it's manufactured by Azurity Pharmaceuticals. This information was generated using AI and is provided for informational and research purposes only.
Compound 528368: Nornicotine, N-butanoyl

Chemical compound data from PubChem database. IUPAC Name: 1-(2-pyridin-3-ylpyrrolidin-1-yl)butan-1-one. Molecular Formula: C13H18N2O. Molecular Weight: 218.29. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 527170: 1,8-Dimethyl-4-propan-2-ylspiro[4.5]deca-7,9-diene

Chemical compound data from PubChem database. IUPAC Name: 1,8-dimethyl-4-propan-2-ylspiro[4.5]deca-7,9-diene. Molecular Formula: C15H24. Molecular Weight: 204.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
SDOH Measures for ZCTA, ACS 2017-2021

This dataset contains ZCTA-level social determinants of health (SDOH) measures from the American Community Survey 5-year data for the entire United States—50 states and the District of Columbia. Data were downloaded from data.census.gov using Census API and processed by the Centers for Disease Control and Prevention (CDC), Division of Population Health, Epidemiology and Surveillance Branch. The project was funded by the Robert Wood Johnson Foundation in conjunction with the CDC Foundation. These measures complement existing PLACES measures, including PLACES SDOH measures (e.g., health insurance, routine check-up). These data can be used together with PLACES data to identify which health and SDOH issues overlap in a community to help inform public health planning.  

To access spatial data, please use the ArcGIS Online service:  https://cdcarcgis.maps.arcgis.com/home/item.html?id=d51009ea78b54635be95c6ec9955ec17.
Child and Family Services Reviews Update Volume 16, Issue 4, October 2022

This issue of Child and Family Services Reviews Update contains the following sections: Round 4 Year 1 Schedule, diverse agile staff sought for CFSRs, Round 4 Procedures Manual released, Round 4 Online Monitoring System (OMS) launched, Round 4 Data Profiles, visualizations released, new resources added to the CFSR Information Portal, and the Child Welfare Virtual Expo.

Metadata-only record linking to the original dataset. Open original dataset below.
Compound 530782: p-Methoxybenzoic acid, 5-phenylpentyl ester

Chemical compound data from PubChem database. IUPAC Name: 5-phenylpentyl 4-methoxybenzoate. Molecular Formula: C19H22O3. Molecular Weight: 298.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
A Projectile Concussive Impact Model Produces Neuroinflammation in Both Mild and Moderate-Severe Traumatic Brain Injury

Traumatic brain injury (TBI) is as a major cause of death and disability experienced by nearly 3 million people annually resulting from falls, vehicular accidents, or from being struck by or against an object. While TBIs can range in severity, the majority of injuries are considered to be mild. However, TBI of any severity has the potential to have long-lasting neurological effects including headaches, cognitive/memory impairments, mood dysfunction, and fatigue as a result of neuronal damage and neuroinflammation. The goal of the study was to evaluate the neuroinflammatory and neuronal damage outcomes associated with mild or moderate-severe TBI via the modification of an established closed-head injury model of TBI by varying the material of the projectile.  Rats that received TBI using a stainless steel projectile exhibited outcomes strongly correlated to moderate-severe TBI, such as prolonged unconsciousness, impaired neurobehavior, increased risk for hematoma and death, as well as significant neuronal degeneration and neuroinflammation throughout the cortex, hippocampus, thalamus, and cerebellum.  In contrast, rats that received TBI with an aluminum projectile exhibited characteristics more congruous with mild TBI, such as a trend for longer periods of unconscious in the absence of neurobehavioral deficits, a lack of neurodegeneration and mild neuroinflammation.  Our results indicate that different levels of behavioral, neuroinflammatory, and damage outcomes are associated with differing levels of TBI severity.
A novel link between the proteasome pathway and the signal transduction pathway of the Bone Morphogenetic Proteins (BMPs)

Background
          The intracellular signaling events of the Bone Morphogenetic Proteins (BMPs) involve the R-Smad family members Smad1, Smad5, Smad8 and the Co-Smad, Smad4. Smads are currently considered to be DNA-binding transcriptional modulators and shown to recruit the master transcriptional co-activator CBP/p300 for transcriptional activation. SNIP1 is a recently discovered novel repressor of CBP/p300. Currently, the detailed molecular mechanisms that allow R-Smads and Co-Smad to co-operatively modulate transcription events are not fully understood.
        
        
          Results
          Here we report a novel physical and functional link between Smad1 and the 26S proteasome that contributes to Smad1- and Smad4-mediated transcriptional regulation. Smad1 forms a complex with a proteasome β subunit HsN3 and the ornithine decarboxylase antizyme (Az). The interaction is enhanced upon BMP type I receptor activation and occur prior to the incorporation of HsN3 into the mature 20S proteasome. Furthermore, BMPs trigger the translocation of Smad1, HsN3 and Az into the nucleus, where the novel CBP/p300 repressor protein SNIP1 is further recruited to Smad1/HsN3/Az complex and degraded in a Smad1-, Smad4- and Az-dependent fashion. The degradation of the CBP/p300 repressor SNIP1 is likely an essential step for Smad1-, Smad4-mediated transcriptional activation, since increased SNIP1 expression inhibits BMP-induced gene responses.
        
        
          Conclusions
          Our studies thus add two additional important functional partners of Smad1 into the signaling web of BMPs and also suggest a novel mechanism for Smad1 and Smad4 to co-modulate transcription via regulating proteasomal degradation of CBP/p300 repressor SNIP1.
Children with SHCN: Data Brief 2

The results of Brief 1 indicated that children with special health care needs (SHCN) experienced more challenges in foster care compared to the experiences of children with no SHCN. However, it is important to evaluate which condition(s) is contributing the most to these variations. In addition to examining the same child welfare outcomes that were evaluated in Brief 1, this brief investigates the child’s removal from home while also considering the type of diagnosis or diagnoses of the child.

Metadata-only record linking to the original dataset. Open original dataset below.
Compound 529977: Heptadecane, 7-butyl-8-methyl

Chemical compound data from PubChem database. IUPAC Name: 7-butyl-8-methylheptadecane. Molecular Formula: C22H46. Molecular Weight: 310.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
CDPHE Health Facilities

Point geometry feature class representing known regulated health facilities in Colorado, developed directly from address information obtained directly from the Health Facilities and Emergency Medical Services Division of the Colorado Department of Public Health and Environment in January of 2017.  Coordinate locations (latitude/longitude) were derived from the known street addresses of health facilities using a combination of Centrus MapMarker geocoding software and Google Earth imagery locations.  This file was developed for use in activities and exercises within the Colorado Department of Public Health and Environment.
Detroit: Drug-Related Emergency Department Visits, 2004-2011 - All Misuse and Abuse

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving drug misuse or abuse in the Detroit metropolitan area, covering 2004-2011. Drug misuse/abuse visits include the use of illicit drugs, nonmedical use of pharmaceuticals, underage drinking and visits where alcohol was combined with another drug.
Weekly Cumulative Estimated Number of Updated 2023-24 COVID-19 Vaccinations Administered in Pharmacies and Physician Medical Offices, Adults 18 years and older, United States, Data Source(s): IQVIA Pharmacy and Physician Medical Office Claims

Weekly Cumulative Estimated Number of Updated 2023-24 COVID-19 Vaccinations Administered in Pharmacies and Physical Medical Offices, Adults 18 Years and Older, United States 

• Estimated number of updated COVID-19 vaccinations among adults 18 years and older is assessed through IQVIA (https://www.iqvia.com/) as a source of information on vaccinations administered in retail pharmacies (include chain, mass merchandise, food stores, and independent pharmacies) and physician medical offices. 

• Starting in September 2023, the CDC recommended the updated 2023-2024 COVID-19 vaccine for adults ages 18 years and older.
Compound 525508: 7-Methyl-4-thia-1-octyne

Chemical compound data from PubChem database. IUPAC Name: 3-methyl-1-prop-2-ynylsulfanylbutane. Molecular Formula: C8H14S. Molecular Weight: 142.26. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E400780-T1: [Translated] VESSEL FOR A METALLURGICAL MELTING UNIT

The tank (1) has an upper part (2) and a lower part (3) with a collar (7). The upper part totally bridges an annular cooling device. The cooling device is in the form of an intermediate ring (4). The upper part rests on the lower part only below the cooling device, and only on the collar of the lower part, so that the intermediate ring is completely free of static load.
QHP Landscape PY2025 Individual Dental

The Dental Individual Market file of the QHP Landscape Files contains information on certified dental plans offered through an Exchange to consumers in the individual market. These plans are also known as Stand-alone Dental Plans (SADPs). The file reports plans offered by county for states in the Federally-facilitated Exchanges including states performing plan management functions, and State Based Exchanges using the federal platform for eligibility and enrollment.
Polarized Th2 like cells, in the absence of Th0 cells, are responsible for lymphocyte produced IL-4 in high IgE-producer schistosomiasis patients

Background
          Human resistance to re-infection with S. mansoni is correlated with high levels of anti-soluble adult worm antigens (SWAP) IgE. Although it has been shown that IL-4 and IL-5 are crucial in establishing IgE responses in vitro, the active in vivo production of these cytokines by T cells, and the degree of polarization of Th2 vs. Th0 in human schistosomiasis is not known. To address this question, we determined the frequency of IL-4 and IFN-γ or IL-5 and IL-2 producing lymphocytes from schistosomiasis patients with high or low levels of IgE anti-SWAP.
        
        
          Results
          Our analysis showed that high and low IgE-producers responded equally to schistosomiasis antigens as determined by proliferation. Moreover, patients from both groups displayed similar percentages of circulating lymphocytes. However, high IgE-producers had an increased percentage of activated CD4+ T cells as compared to the low IgE-producers. Moreover, intracellular cytokine analysis, after short-term stimulation with anti-CD3/CD28 mAbs, showed that IgE high-producers display an increase in the percentage of T lymphocytes expressing IL-4 and IL-5 as compared to IgE low-responders. A coordinate control of the frequency of IL-4 and IL-5 producing lymphocytes in IgE high, but not IgE low-responders, was observed.
        
        
          Conclusions
          High IgE phenotype human schistosomiasis patients exhibit a coordinate regulation of IL-4 and IL-5 producing cells and the lymphocyte derived IL-4 comes from true polarized Th2 like cells, in the absence of measurable Th0 cells as measured by co-production of IL-4 and IFN-γ.
Compound 527217: Isointermedeol

Chemical compound data from PubChem database. IUPAC Name: 1,4a-dimethyl-7-prop-1-en-2-yl-2,3,4,5,6,7,8,8a-octahydronaphthalen-1-ol. Molecular Formula: C15H26O. Molecular Weight: 222.37. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528798: Ethyl 4-amino-7-chloro-3-quinolinecarboxylate

Chemical compound data from PubChem database. IUPAC Name: 2,2,4,4,6,6,8,8,10,10,12,12,14,14,16,16,18,18,20,20,22,22,24,24,26,26,28,28,30,30,32,32,34,34,36,36,38,38,40,40,42,42,44,44,46,46,48,48,50,50,52,52,54,54,56,56,58,58,60,60,62,62,64,64,66,66,68,68,70,70,72,72,74,74,76,76,78,78,80,80,82,82,84,84,86,86-hexaoctacontamethyl-1,3,5,7,9,11,13,15,17,19,21,23,25,27,29,31,33,35,37,39,41,43,45,47,49,51,53,55,57,59,61,63,65,67,69,71,73,75,77,79,81,83,85-tritetracontaoxa-2,4,6,8,10,12,14,16,18,20,22,24,26,28,30,32,34,36,38,40,42,44,46,48,50,52,54,56,58,60,62,64,66,68,70,72,74,76,78,80,82,84,86-tritetracontasilacyclohexaoctacontane. Molecular Formula: C86H258O43Si43. Molecular Weight: 3188.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E401504-T1: [Translated] ADJUSTABLE STOP ARRANGEMENT FOR A PISTON-CYLINDER UNIT

The invention concerns an adjustable stop assembly, for limiting a stroke, designed for a piston-cylinder unit comprising a cylinder and a piston having a rod, said stop assembly serving to limit the stroke of a lifting device on a forklift truck. Said assembly has a clamping ring (2) axially slidable and lockable on the piston rod, comprising, in one region of its external periphery, a threaded portion. Said assembly also comprises a threaded ring (3) which can be screwed on the threaded portion of the clamping ring and whereof the side facing the cylinder serves as stop thereon.
ACF and DOL webinar on Child Labor Exploitation

The Administration for Children and Families (ACF) and the Department of Labor’s (DOL) Wage and Hour Division hosted a webinar providing an overview of the Division and the laws and outreach behind its mission. Learn how the agency promotes and achieves compliance with labor standards to protect the welfare of the nation's workforce. The presentation focuses on child labor laws and ways in which child labor investigations are conducted, and participants learned how the public can file a complaint.

Metadata-only record linking to the original dataset. Open original dataset below.
Hospital Suspensions

<strong>A. SUMMARY</strong>
This dataset includes system-wide hospital diversion suspension information. 

<strong>B. HOW THE DATASET IS CREATED</strong>
This dataset contains the date and time diversion suspension began and ended. Hospitals can voluntarily declare diversion, which diverts all ambulance transports away from the given hospital excepting specialty care transports. However, when 4 or more hospitals go on diversion at the same time, diversion is suspended system-wide for 4 hours. This is called diversion suspension.

<strong>C. UPDATE PROCESS</strong>
The data is updated monthly by San Francisco Emergency Medical Services Agency.

<strong>D. HOW TO USE THIS DATASET</strong>
When 4 or more San Francisco hospitals declare diversion status, diversion gets suspended for all hospitals. Diversion suspension lasts for 4 hours until it ends and hospitals can declare diversion again. Please refer to the <u><a href="https://data.staff.sf.gov/Health-and-Social-Services/Hospital-Diversions/t4sf-777q/">Hospital Diversions dataset</a></u> for more information on diversion.