AndreaBozzo/ceres-open-data-index huggingface dataset:
Compound 529365: Leu, N-isoBOC TBDMS

Chemical compound data from PubChem database. IUPAC Name: [tert-butyl(dimethyl)silyl] 4-methyl-2-(2-methylpropoxycarbonylamino)pentanoate. Molecular Formula: C17H35NO4Si. Molecular Weight: 345.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
National Survey of Substance Abuse Treatment Services: State Profiles 2004

The 2004 National Survey of Substance Abuse Treatment Services (N-SSATS) is an annual survey of facilities providing substance abuse treatment. The N-SSATS, conducted by the Substance Abuse and Mental Health Services Administration (SAMHSA), is designed to collect data on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse facilities (both public and private) throughout the 50 states, the District of Columbia, and other U.S. jurisdictions.
Compound 527511: 1H-Pyrrole, 1-(1-methylethyl)-

Chemical compound data from PubChem database. IUPAC Name: 1-propan-2-ylpyrrole. Molecular Formula: C7H11N. Molecular Weight: 109.17. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 530442: 4-Ethylbenzoic acid, 4-hexadecyl ester

Chemical compound data from PubChem database. IUPAC Name: hexadecan-4-yl 4-ethylbenzoate. Molecular Formula: C25H42O2. Molecular Weight: 374.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Gene expression profile of HIV-1 Tat expressing cells: a close interplay between proliferative and differentiation signals

Background
          Expression profiling holds great promise for rapid host genome functional analysis. It is plausible that host expression profiling in an infection could serve as a universal phenotype in virally infected cells. Here, we describe the effect of one of the most critical viral activators, Tat, in HIV-1 infected and Tat expressing cells. We utilized microarray analysis from uninfected, latently HIV-1 infected cells, as well as cells that express Tat, to decipher some of the cellular changes associated with this viral activator.
        
        
          Results
          Utilizing uninfected, HIV-1 latently infected cells, and Tat expressing cells, we observed that most of the cellular host genes in Tat expressing cells were down-regulated. The down-regulation in Tat expressing cells is most apparent on cellular receptors that have intrinsic receptor tyrosine kinase (RTK) activity and signal transduction members that mediate RTK function, including Ras-Raf-MEK pathway. Co-activators of transcription, such as p300/CBP and SRC-1, which mediate gene expression related to hormone receptor genes, were also found to be down-regulated. Down-regulation of receptors may allow latent HIV-1 infected cells to either hide from the immune system or avoid extracellular differentiation signals. Some of the genes that were up-regulated included co-receptors for HIV-1 entry, translation machinery, and cell cycle regulatory proteins.
        
        
          Conclusions
          We have demonstrated, through a microarray approach, that HIV-1 Tat is able to regulate many cellular genes that are involved in cell signaling, translation and ultimately control the host proliferative and differentiation signals.
Compound 530516: 5-Bromovaleric acid, tridecyl ester

Chemical compound data from PubChem database. IUPAC Name: tridecyl 5-bromopentanoate. Molecular Formula: C18H35BrO2. Molecular Weight: 363.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 526896: 2-(2-Isopentoxyethoxy)ethanol

Chemical compound data from PubChem database. IUPAC Name: 2-[2-(3-methylbutoxy)ethoxy]ethanol. Molecular Formula: C9H20O3. Molecular Weight: 176.25. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 527178: 7,7-Dimethyl-6-methylidenetricyclo[6.2.1.01,5]undecan-2-ol

Chemical compound data from PubChem database. IUPAC Name: 7,7-dimethyl-6-methylidenetricyclo[6.2.1.01,5]undecan-2-ol. Molecular Formula: C14H22O. Molecular Weight: 206.32. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 529122: 4-Quinazolone, 3-methyl-2-propyl

Chemical compound data from PubChem database. IUPAC Name: 3-methyl-2-propylquinazolin-4-one. Molecular Formula: C12H14N2O. Molecular Weight: 202.25. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
The association between secondhand smoke and the risk of developing acute coronary syndromes, among non-smokers, under the presence of several cardiovascular risk factors: The CARDIO2000 case-control study

Background
          The purpose of this study was to investigate the association between secondhand smoke and the risk of developing a first event of acute coronary syndromes (ACS), i.e. acute myocardial infarction or unstable angina, among non-smokers, in relation to the presence of several other cardiovascular risk factors.
        
        
          Methods
          Eight hundred and forty-eight patients with first event of ACS and 1078 cardiovascular disease-free matched controls completed a detailed questionnaire regarding their exposure to secondhand smoke, among other investigated parameters.
        
        
          Results
          Two hundred and ninety–seven (35%) of the patients and 259 (24%) of the controls were defined as secondhand smokers. After controlling for several potential confounders, the results showed that non-smokers occasionally (< 3 time per week) exposed to cigarette smoke were associated with 26% higher risk of ACS (OR = 1.26, P-value < 0.01) compared to non-smokers not exposed to smoke, while regular exposure is associated with 99% higher risk of developing ACS (OR = 1.99, P-value < 0.001). Moreover, the previous risk increases progressively from 15% to 256% if one or more of the classical cardiovascular risk factors (i.e. hypertension, hypercholesterolemia, diabetes mellitus, sedentary life and family history of premature coronary heart disease) are present.
        
        
          Conclusions
          Consequently, this study supports the hypothesis that even occasional secondhand smoke increases the risk of developing acute coronary syndromes, especially when other risk factors are present. Given the high prevalence of cigarette smoking, the public health consequences of passive smoking with regard to coronary heart disease are important.
Lisdexamfetamine dimesylate

Lisdexamfetamine Dimesylate is a generic prescription medication manufactured by Hikma Pharmaceuticals USA Inc. It's a central nervous system stimulant classified as a DEA Schedule II controlled substance, available in oral capsule form in strengths of 10mg, 20mg, 30mg, 40mg, 50mg, 60mg, and 70mg. This information was generated using AI and is provided for informational and research purposes only.
FDA Recognized Consensus Standards

This database consists of those national and international standards recognized by FDA which manufacturers can declare conformity to and is part of the information the Center can use to make an appropriate decision regarding the clearance or approval of a submission. Information submitted on conformance with such standards will have a direct bearing on safety and effectiveness determinations made during the review of IDEs, HDEs, PMAs, and PDPs. Conformance with recognized consensus standards in and of itself, however, may not always be a sufficient basis for regulatory decisions.
Compound 528601: tert-Butyl(dimethyl)silyl undecanoate

Chemical compound data from PubChem database. IUPAC Name: [tert-butyl(dimethyl)silyl] undecanoate. Molecular Formula: C17H36O2Si. Molecular Weight: 300.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528783: Cyclononadecasiloxane, octatriacontamethyl-

Chemical compound data from PubChem database. IUPAC Name: 2,2,4,4,6,6,8,8,10,10,12,12,14,14,16,16,18,18,20,20,22,22,24,24,26,26,28,28,30,30,32,32,34,34,36,36,38,38-octatriacontamethyl-1,3,5,7,9,11,13,15,17,19,21,23,25,27,29,31,33,35,37-nonadecaoxa-2,4,6,8,10,12,14,16,18,20,22,24,26,28,30,32,34,36,38-nonadecasilacyclooctatriacontane. Molecular Formula: C38H114O19Si19. Molecular Weight: 1408.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E400453-T1: [Translated] COMPOSITE BICYCLE RIM AND METHOD FOR PRODUCING SAME

A bicycle rim (1) made of composite material based on structural fibres incorporated in a polymeric material is described, characterised in that it comprises at least one circumferential reinforcement element (16, 16a) based on unidirectional structural fibres extending at a respective intersection of walls of the rim, the direction of the structural fibre being circumferential. A method for making such a bicycle rim is also described. <IMAGE>
Patent AT-E40117-T1: [Translated] O-SUBSTITUTED 3-OXYPYRIDINIUM SALTS, PROCESS FOR THEIR PRODUCTION AND USE AS PLANT PROTECTION FUNGICIDES.

O-substituted 3-oxypyridinium salts of the formula    <IMAGE>  I where R1 is unsubstituted alkyl, alkenyl or alkynyl, or is aralkyl, R3 is hydrogen, alkyl, alkenyl or alkoxy, R2 is substituted or unsubstituted alkyl, alkenyl or alkynyl, or is aralkyl, and X(-) is an anion, and fungicides for crop protection containing these compounds.
FY 2007 Children's Bureau Discretionary Grant Awards

This document provides a list of Children's Bureau discretionary grants awarded in fiscal year 2007:

2007 National Child Welfare Leadership Institute (CFDA # 93.648)
Up to $1,168,142 over 17 months.

Targeted Grants to Increase the Well-Being of, and to Improve the Permanency Outcomes for, Children Affected by Methamphetamine or Other Substance Abuse (CFDA # 93.087)

Preventing Child Abuse and Neglect Through Nurse Home Visitation (CFDA # 93.670)
Up to $400,000 per year for 5 years.

Using Comprehensive Family Assessments to Improve Child Welfare Outcomes (CFDA # 93.670)
Up to $400,000 per year for 5 years.

AdoptUsKids (CFDA # 93.254)
Up to $3,669,500 per year for 5 years.

Metadata-only record linking to the original dataset. Open original dataset below.
Reducing Substance Use Among Clients in the Pregnant and Postpartum Women Pilot Program

This CBHSQ Spotlight presents findings from an evaluation of the State Pilot Program for Treatment for Pregnant and Postpartum Women (PPW-PLT). This pilot program was designed to complement the residential PPW program by developing a continuum of family-centered care services in an outpatient setting. This spotlight compares program clients’ self-reported substance use from data collected at the intake and six-month follow up interviews.
DASH - Youth Risk Behavior Surveillance System (YRBSS): High School –  Including Sexual Orientation

2015-2017. High School Dataset – Including Sexual Orientation. The Youth Risk Behavior Surveillance System (YRBSS) monitors six categories of priority health behaviors
among youth and young adults: 1) behaviors that contribute to unintentional injuries and violence; 2) tobacco use; 3) alcohol and
other drug use; 4) sexual behaviors related to unintended pregnancy and sexually transmitted infections (STIs), including human
immunodeficiency virus (HIV) infection; 5) unhealthy dietary behaviors; and 6) physical inactivity. In addition, YRBSS monitors
the prevalence of obesity and asthma and other priority health behaviors.  This dataset contains national, state, and local data from 2015 that includes two aspects of sexual orientation – sexual identity and sex of sexual contacts.  Additional information about the YRBSS can be found at www.cdc.gov/yrbss.
San Francisco Department of Public Health Flu Shot Locations 2013

List of San Francisco Department of Public Health clinics offering flu vaccinations throughout the city in fall 2013.This dataset complies with the  emerging Data Specification for Flu Shot Locations. For information about the specification, please see https://github.com/CityOfPhiladelphia/flu-shot-spec.For more information about SFDPH's Influenza Program  www.sfcdcp.org/flu or call 311For more information about SFDPH's Open data Initiatives http://www.sfphes.org/resources/health-data or Contact Cyndy.comerford@sfdph.org
Compound 529516: Arg, TBDMS

Chemical compound data from PubChem database. IUPAC Name: [tert-butyl(dimethyl)silyl] 5-[bis[[tert-butyl(dimethyl)silyl]amino]methylideneamino]-2-[[tert-butyl(dimethyl)silyl]amino]pentanoate. Molecular Formula: C30H70N4O2Si4. Molecular Weight: 631.2. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 529938: 3,5-Dimethyl-1,2-dithian-4-one

Chemical compound data from PubChem database. IUPAC Name: 3,5-dimethyldithian-4-one. Molecular Formula: C6H10OS2. Molecular Weight: 162.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Two pathways act in an additive rather than obligatorily synergistic fashion to induce systemic acquired resistance and

Background
          Local infection with necrotizing pathogens induces whole plant immunity to secondary challenge. Pathogenesis-related genes are induced in parallel with this systemic acquired resistance response and thought to be co-regulated. The hypothesis of co-regulation has been challenged by induction of Arabidopsis PR-1 but not systemic acquired resistance in npr1 mutant plants responding to Pseudomonas syringae carrying the avirulence gene avrRpt2. However, experiments with ndr1 mutant plants have revealed major differences between avirulence genes. The ndr1-1 mutation prevents hypersensitive cell death, systemic acquired resistance and PR-1 induction elicited by bacteria carrying avrRpt2. This mutation does not prevent these responses to bacteria carrying avrB.
        
        
          Results
          Systemic acquired resistance, PR-1 induction and PR-5 induction were assessed in comparisons of npr1-2 and ndr1-1 mutant plants, double mutant plants, and wild-type plants. Systemic acquired resistance was displayed by all four plant lines in response to Pseudomonas syringae bacteria carrying avrB. PR-1 induction was partially impaired by either single mutation in response to either bacterial strain, but only fully impaired in the double mutant in response to avrRpt2. PR-5 induction was not fully impaired in any of the mutants in response to either avirulence gene.
        
        
          Conclusion
          Two pathways act additively, rather than in an obligatorily synergistic fashion, to induce systemic acquired resistance, PR-1 and PR-5. One of these pathways is NPR1-independent and depends on signals associated with hypersensitive cell death. The other pathway is dependent on salicylic acid accumulation and acts through NPR1. At least two other pathways also contribute additively to PR-5 induction.
Multi site polyadenylation and transcriptional response to stress of a vacuolar type H

Background
          Vacuolar type H+-ATPases play a critical role in the maintenance of vacuolar homeostasis in plant cells. V-ATPases are also involved in plants' defense against environmental stress. This research examined the expression and regulation of the catalytic subunit of the vacuolar type H+-ATPase in Arabidopsis thaliana and the effect of environmental stress on multiple transcripts generated by this gene.
        
        
          Results
          Evidence suggests that subunit A of the vacuolar type H+-ATPase is encoded by a single gene in Arabidopsis thaliana. Genome blot analysis showed no indication of a second subunit A gene being present. The single gene identified was shown by whole RNA blot analysis to be transcribed in all organs of the plant. Subunit A was shown by sequencing the 3' end of multiple cDNA clones to exhibit multi site polyadenylation. Four different poly (A) tail attachment sites were revealed. Experiments were performed to determine the response of transcript levels for subunit A to environmental stress. A PCR based strategy was devised to amplify the four different transcripts from the subunit A gene.
        
        
          Conclusions
          Amplification of cDNA generated from seedlings exposed to cold, salt stress, and etiolation showed that transcript levels for subunit A of the vacuolar type H+-ATPase in Arabidopsis were responsive to stress conditions. Cold and salt stress resulted in a 2–4 fold increase in all four subunit A transcripts evaluated. Etiolation resulted in a slight increase in transcript levels. All four transcripts appeared to behave identically with respect to stress conditions tested with no significant differential regulation.
Patent AT-E399602-T1: [Translated] COATED ALUMINUM SEMI-FINISHED PRODUCTS AND/OR COMPONENTS AND METHODS FOR THEIR PRODUCTION

The invention relates to the field of chemistry and concerns coated reshaped aluminum semi-finished products and/or components which are coated with a two-step hardening/cross-linking coating agent and a method for the production thereof. The aim of the invention is to disclose and to produce coated reshaped aluminum semi-finished products and/or components which as semi-finished products can still be re-shaped and hardened at high temperatures. The object is attained through coated reshaped aluminum semi-finished products and/or components which are coated with an at least two-step hardening/cross-linking coating agent and at most partially hardened/cross linked, and the formed coating film is elastic. The object is also attained through a method in which aluminum semi-finished products and/or components are coated with at least one coating agent and the layer(s) in a first step are covered with film and partially hardened/partially cross-linked and substantially hardened/cross-linked in an at least second step during and/or after at least one reshaping process.
Patent AT-E400574-T1: [Translated] PYRROLOPYRIDINE-2-CARBONIC ACID AMIDE DERIVATIVE FOR USE AS AN INHIBITOR AGAINST GLYCOGEN PHOSPHORYLASE

The present invention is directed to a novel form of a pyrrolopyridine-2-carboxylic acid amide of formula (I), which is an inhibitor of glycogen phosphorylase, compositions containing it and their use in therapy. The invention is also directed to processes for production of the novel form, novel intermediates used in said processes and processes for the production of said intermediates.
'Round-table' ethical debate: is a suicide note an authoritative 'living will'?

Living wills are often considered by physicians who are faced with a dying patient. Although popular with the general public, they remain problems of authenticity and authority. It is difficult for the examining physician to know whether the patient understood the terms of the advance directive when they signed it, and whether they still consider it authoritative at the time that it is produced. Also, there is little consensus on what spectrum of instruments constitutes a binding advance directive in real life. Does a 'suicide note' constitute an authentic and authoritative 'living will'? Our panel of authorities considers this problem in a round-table discussion.
Compound 527734: Propanoic acid, 3-bromo-2-chloro, methyl ester

Chemical compound data from PubChem database. IUPAC Name: methyl 3-bromo-2-chloropropanoate. Molecular Formula: C4H6BrClO2. Molecular Weight: 201.44. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 526006: 3-Trimethylsiloxy(trimethylsilyl)caproate

Chemical compound data from PubChem database. IUPAC Name: trimethylsilyl 3-trimethylsilyloxyhexanoate. Molecular Formula: C12H28O3Si2. Molecular Weight: 276.52. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E401183-T1: [Translated] METHOD FOR PRODUCING MOLDED PARTS BY GAS-ASSISTED INJECTION MOLDING

Pressurized gas passes through a control valve (2) to the molding tool (3) and is introduced through a nozzle (6) into the molded component (4). Before reaching the tool (3), a cooling medium (8) is injected through a transfer valve (7). The cooling medium can be water, liquid or gaseous nitrogen, or liquid or gaseous carbon dioxide. An independent claim is also included for the corresponding equipment, incorporating controls to obtain optimum cooling of the component.
Silodosin

Silodosin is a prescription medication classified as an alpha-adrenergic blocker, used to treat symptoms of benign prostatic hyperplasia (BPH) in men, such as difficulty urinating. It comes in oral capsules at 4 mg and 8 mg strengths, manufactured by Camber Pharmaceuticals, Inc. under ANDA204793. This information was generated using AI and is provided for informational and research purposes only.
Haloperidol

Haloperidol is a generic antipsychotic medication used to manage symptoms of schizophrenia, bipolar disorder, and other mental health conditions. It comes as oral tablets in strengths of 0.5mg, 1mg, 2mg, 5mg, 10mg, and 20mg, manufactured by Lifestar Pharma LLC under ANDA216918. This information was generated using AI and is provided for informational and research purposes only.