AndreaBozzo/ceres-open-data-index huggingface dataset:
Anti-cytokine therapy in fibrosing alveolitis: where are we now?

Idiopathic pulmonary fibrosis (IPF) is a condition that has a poor prognosis, with a median survival of 4-5 years irrespective of treatment. Ziesche et al (N Engl J Med 1999, 341: 1264-1269) describe an open randomised trial of 18 patients with IPF, unresponsive to corticosteroid treatment at high dose. Nine patients were treated with continued corticosteroid and nine with prednisolone plus interferon-γ 1b (IFN-γ). Significant benefits in physiological parameters are reported in the IFN-γ-treated group. An analysis of lung tissue by reverse-transcriptase-mediated polymerase chain reaction showed corresponding decreases in the transcription of transforming growth factor-β1 and connective tissue growth factor. This is the first report of treatment showing efficacy in this disease, albeit in a very preliminary study, but the data should be viewed with caution. This study is discussed in the context of other published studies of treatment for IPF and the scientific rationale on which it was based.
Lyme disease and current aspects of immunization

Lyme disease is a tick-borne multisystem disease that affects primarily the skin, nervous system, heart and joints. At least three species of Borrelia burgdorferi sensu lato, namely Borrelia burgdorferi sensu stricto, Borrelia garinii, and Borrelia afzelii, can cause the disease. This review will focus mainly on the pathophysiology of Lyme arthritis, the long-term outcome of Lyme disease, and the recently licensed vaccine against Lyme disease.
Compound 528581: Bis[tert-butyl(dimethyl)silyl] 2-([tert-butyl(dimethyl)silyl]oxy)succinate

Chemical compound data from PubChem database. IUPAC Name: bis[tert-butyl(dimethyl)silyl] 2-[tert-butyl(dimethyl)silyl]oxybutanedioate. Molecular Formula: C22H48O5Si3. Molecular Weight: 476.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Child Welfare Information System Project SoftWare and Artifact Pool (C-SWAP) Access Application

The C-SWAP Access Application must be approved in order to receive access to this secure site. Users must be state or tribal merit employees who actively work with child welfare information system projects. Vendor staff will not be allowed access.

Please submit completed applications to C-SWAP.Notifications@acf.hhs.gov and copy your federal analyst for review. All applications will receive a response, and approved users will receive a user ID and new user password at that time.

Users that do not have an email address that is part of Microsoft's preferred network at the time of the C-SWAP account creation will receive instructions from the C-SWAP administrator about how to create an Outlook.com email address for use when logging into the C-SWAP website. After users create the Outlook.com email address, users will provide the email address to the C-SWAP administrator, who will create their C-SWAP account. Accessing the C-SWAP site is the sole intended use of this Outlook.com email address. As with any application, users will be responsible for maintaining this account.

Metadata-only record linking to the original dataset. Open original dataset below.
Autoantibodies in cryptogenic fibrosing alveolitis

The pathogenesis of cryptogenic fibrosing alveolitis (CFA) involves injury, an immune/inflammatory response and fibrosis. The cause of the injury is unknown, but the identification of serum autoantibodies makes an autoimmune aetiology attractive. The core study on which this commentary is based used novel cloning and serum screening technologies in order to identify new public and private autoantibodies in sera from 12 patients with CFA. Largely negative conclusions were drawn from that study. However, we suggest that the prevalence of autoantibodies may have been underestimated, that the study was timely and that this approach is worth pursuing further.
Fluconazole

Fluconazole is an oral antifungal suspension used to treat fungal infections. This prescription drug, with a strength of 40 mg/mL, is manufactured by Zhejiang Poly Pharm. Co., Ltd. and approved under ANDA215738. It belongs to the azole class of antifungals and works by inhibiting fungal growth. This information was generated using AI and is provided for informational and research purposes only.
Evidence that the RNAseH activity of the duck hepatitis B virus is unable to act on exogenous substrates

Background
          The hepadnaviral reverse transcriptase can synthesize DNA on its native RNA template within viral cores but it is usually unable to synthesize DNA employing exogenous nucleic acids as a template. The mechanism of this template commitment is unknown. Here we provide evidence that the RNAseH activity of duck hepatitis B virus reverse transcriptase may also be unable to act on exogenous substrates.
        
        
          Results
          RNAseH assays were performed under a wide variety of conditions employing substrate RNAs of Duck Hepatitis B Virus sequence annealed to complementary DNA oligonucleotides and permeabilized intracellular viral core particles. Temperature, pH, cation type, salt concentration, substrate concentration, and the sequences of the cleavage sites were varied, and the effects of ATP and dNTPs on RNAseH activity were examined. duck hepatitis B virus RNAseH activity was not detected under any of these conditions, although E. coli or Avian Myeloblastosis Virus RNAseH activity could be detected under all conditions. Access of the RNA substrate to the enzyme within the viral cores was confirmed.
        
        
          Conclusions
          These results imply that the RNAseH activity of the DHBV reverse transcriptase may not be able to degrade exogenous RNA:DNA heteroduplexes, although it can degrade heteroduplexes of the same sequence generated during reverse transcription of the endogenous RNA template. Therefore, the RNAseH activity appears to be "substrate committed" in a manner similar to the template commitment observed for the DNA polymerase activity.
2022-2023 NSDUH: Model-Based Estimated Prevalence for States

Browse state-level percentage estimates based on the 2022-2023 National Surveys on Drug Use and Health (NSDUH). The 41 tables include estimates for measures of both substance use and mental health, by age group, along with 95% confidence intervals. The percentages are based on small area estimation (SAE) methods, in which state-level NSDUH data are combined with other data from smaller geographies. The combined data are used to create modeled state estimates of the civilian, noninstitutionalized population ages 12 and older (or adults 18 and older for mental health measures). Most tables cover a single measure by state, region, and age group. A few tables cover multiple measures for just ages 12 to 20.The tables are available as an Excel spreadsheet, a PDF file, or as a zip file containing CSV text files.
Nursing Home Cost Report (RHCF): 2017

The Nursing Home Cost Report (RHCF) is a uniform report completed by New York nursing homes to report income, expenses, assets, liabilities, and statistics to the Department of Health (DOH). Under DOH regulations (Part 86-2.2), nursing homes are required to file financial and statistical data with DOH annually. The data filed is part of the cost report and is received electronically through a secured network. This data is used to develop Medicaid rates, assist in the formulation of reimbursement methodologies, and analyze trends.
Circadian rhythm of glycoprotein secretion in the vas deferens of the moth,

Background
          Reproductive systems of male moths contain circadian clocks, which time the release of sperm bundles from the testis to the upper vas deferens (UVD) and their subsequent transfer from the UVD to the seminal vesicles. Sperm bundles are released from the testis in the evening and are retained in the vas deferens lumen overnight before being transferred to the seminal vesicles. The biological significance of periodic sperm retention in the UVD lumen is not understood. In this study we asked whether there are circadian rhythms in the UVD that are correlated with sperm retention.
        
        
          Results
          We investigated the carbohydrate-rich material present in the UVD wall and lumen during the daily cycle of sperm release using the periodic acid-Shiff reaction (PAS). Males raised in 16:8 light-dark cycles (LD) showed a clear rhythm in the levels of PAS-positive granules in the apical portion of the UVD epithelium. The peak of granule accumulation occurred in the middle of the night and coincided with the maximum presence of sperm bundles in the UVD lumen. These rhythms persisted in constant darkness (DD), indicating that they have circadian nature. They were abolished, however, in constant light (LL) resulting in random patterns of PAS-positive material in the UVD wall. Gel-separation of the UVD homogenates from LD moths followed by detection of carbohydrates on blots revealed daily rhythms in the abundance of specific glycoproteins in the wall and lumen of the UVD.
        
        
          Conclusion
          Secretory activity of the vas deferens epithelium is regulated by the circadian clock. Daily rhythms in accumulation and secretion of several glycoproteins are co-ordinated with periodic retention of sperm in the vas deferens lumen.
Compound 529053: 1,3,5-Dithiazine, perhydro-2,6-dibutyl-4-methyl

Chemical compound data from PubChem database. IUPAC Name: 2,4-dibutyl-6-methyl-1,3,5-dithiazinane. Molecular Formula: C12H25NS2. Molecular Weight: 247.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 530305: Methyl 4-tert-butylcyclohexane-1-carboxylate

Chemical compound data from PubChem database. IUPAC Name: methyl 4-tert-butylcyclohexane-1-carboxylate. Molecular Formula: C12H22O2. Molecular Weight: 198.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
National Survey of Residential Care Facilities - Restricted Facility-Level Dataset

The 2010 National Survey of Residential Care Facilities (NSRCF) is a first-ever national probability sample survey that collects data on U.S. residential care providers, their staffs and services, and the people they serve. It is designed to provide national estimates of the number of residential care facilities operating in the United States, the number of residents receiving care, and the characteristics of both the facilities and their residents. NSRCF was conducted between March and November 2010. All residential care facilities that participated in the survey were places that were licensed, registered, listed, certified, or otherwise regulated by the state and that had 4 or more licensed, certified, or registered beds, provided room and board with at least two meals a day, around-the-clock on-site supervision, and help with personal care such as bathing and dressing or health related services such as medication management. These facilities served a predominantly adult population and had at least one current resident. Facilities licensed to serve the mentally ill or the developmentally disabled populations exclusively were excluded from the survey.
2024 General Payment Data

All general (non-research, non-ownership related) payments from the 2024 program year [January 1 – December 31, 2024]<p><strong>NOTE: </strong>This is a very large file and, depending on your network characteristics and software, may take a long time to download or fail to download. Additionally, the number of rows in the file may be larger than the maximum rows your version of <a href="https://support.microsoft.com/en-us/office/excel-specifications-and-limits-1672b34d-7043-467e-8e27-269d656771c3">Microsoft Excel</a> supports. If you can't download the file, we recommend engaging your IT support staff. If you are able to download the file but are unable to open it in MS Excel or get a message that the data has been truncated, we recommend trying alternative programs such as MS Access, Universal Viewer, Editpad or any other software your organization has available for large datasets.</p>
Behavioral Health Barometer: Alabama, 2013

This is a behavioral health report for the state of Alabama. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment, and medicare enrollees for the years 2008 to 2012.
Compound 526835: 13-Hydroxy-arachidic, methyl ester, tBDMS ether

Chemical compound data from PubChem database. IUPAC Name: methyl 13-[tert-butyl(dimethyl)silyl]oxyicosanoate. Molecular Formula: C27H56O3Si. Molecular Weight: 456.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E401259-T1: [Translated] DEVICE FOR DISPENSING FLUIDS, PARTICULARLY MEDICINAL FLUIDS UNDER PRESSURE

The invention relates to a device of the type adapted to deliver fluids, notably medicaments, under pressure. The device comprises a container 1 of variable volume in the form or shape of a pouch or flexible receptacle of generally cylindrical shape with longitudinal pleats 2 containing the fluid under pressure to be delivered and equipped with an actuator C permitting to open a valve 15 a , 15 b to enable the delivery of said fluid, the whole being located inside a container 4 capable of resisting to an elevated internal pressure, the internal volume of the latter container comprised between its wall and the container of variable volume being filled with a neutral gas under a pressure sufficient to exert on the container of variable volume a pneumatic constraint sufficient to permit the delivery of the therein contained fluid when the above-said valve permitting said delivery is operated by the aforementioned actuator C.
Compound 530103: 4-Aminoimidazole-5-carboxamide, TMS

Chemical compound data from PubChem database. IUPAC Name: N,3-bis(trimethylsilyl)-5-(trimethylsilylamino)imidazole-4-carboxamide. Molecular Formula: C13H30N4OSi3. Molecular Weight: 342.66. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Polyethylene glycol-superoxide dismutase inhibits lipid peroxidation
		  in hepatic ischemia/reperfusion injury

Background:
          Hepatic injury after ischemia/reperfusion is attributed to the
				development of oxygen free radical (OFR)-mediated lipid peroxidation - a
				process that can be measured through its byproducts, specifically
				malondialdehyde. The use of free radical scavengers can offer significant
				protection against OFR-induced liver injury. We hypothesize that a new potent
				OFR scavenger, polyethylene glycol-superoxide dismutase (PEG-SOD), can inhibit
				OFR-mediated lipid peroxidation in hepatic ischemia/reperfusion injury.
        
        
          Methods:
          Twelve male Sprague-Dawley rats (300-350 g) were subjected to
				occlusion of the left and middle hepatic arteries and portal veins for 90 min,
				followed by 120 min reperfusion. PEG-SOD (5000 units/kg) was given intravenously
				before vascular occlusion and again immediately upon reperfusion to six rats.
				Normal saline was given to the remaining six rats to be used as a control
				group. The right hepatic lobe (used as internal control) and left hepatic lobe
				were harvested separately and tissue malondialdehyde was measured.
        
        
          Results:
          A marked increase in lipid peroxide was found in the normal saline
				group after 2 h reperfusion. Treatment with PEG-SOD prevented the rise in tissue
				malondialdehyde. The mean difference in the malondialdehyde between the left
				and right hepatic lobes were 13.20 ± 6.35 and 1.70 ± 3.65 nmol/g in the
				normal saline (control) and PEG-SOD groups, respectively. This difference was
				found to be statistically significant (P < 0.005) using
				Student's t-test.
        
        
          Conclusions:
          PEG-SOD can effectively attenuate hepatic ischemia/reperfusion
				injury by inhibiting OFR-mediated lipid peroxidation.
2010 CMHS Uniform Reporting System (URS) Output Tables for Florida

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
National Artesunate for Severe Malaria Program Microscopy Data- April to December 2019

This dataset includes deidentified data on patients receiving artesunate through the National Artesunate for Severe Malaria Program from April- December 2019. 

This dataset contains microscopy data only.
Please see the links below for the other datasets and the attached document 'Guide to NASMP Datasets:
Data from Case Report Form- https://data.cdc.gov/Global-Health/National-Artesunate-for-Severe-Malaria-Program-Cas/igaz-icki
Data on Artesunate Dosing- https://data.cdc.gov/dataset/National-Artesunate-for-Severe-Malaria-Program-Art/qan4-gt4k
Data on Follow-On Dosing- https://data.cdc.gov/Global-Health/National-Artesunate-for-Severe-Malaria-Program-Fol/g3k9-gyw7

All data can be easily linked using the ParticipantID field, a unique ID number assigned to each participant.
Gut oxygenation in sepsis: Still a matter of controversy?

Part of Stephan Jakob's exhaustive review paper in the present issue of Critical Care deals with the notion that intestinal cellular energetics are deranged in sepsis, in terms not only of inadequate tissue perfusion but also of impaired mitochondrial respiration and/or coupling (i.e. organ dysfunction in sepsis may occur as a result of 'cytopathic hypoxia'). This suggests that efforts to improve outcome in septic patients by manipulating systemic oxygen delivery and regional blood flow are doomed to failure. That suggestion remains largely speculative, and experimental and clinical results presented here consistently demonstrate that there is still a place for treatment of abnormal perfusion in the context of early severe sepsis and septic shock.
Compound 528752: 2-Butyloct-2-enoic acid

Chemical compound data from PubChem database. IUPAC Name: 2-butyloct-2-enoic acid. Molecular Formula: C12H22O2. Molecular Weight: 198.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 526688: 1,7-Dimethyl-4-isopropyl-naphthalene

Chemical compound data from PubChem database. IUPAC Name: 1,5-dimethyl-4-propan-2-ylnaphthalene. Molecular Formula: C15H18. Molecular Weight: 198.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 530263: 4-(tert-Butylsulfonyl)phenyl(dimethyl)amine oxide

Chemical compound data from PubChem database. IUPAC Name: [3-(acetyloxymethyl)-5-(bromomethyl)cyclohexyl]methyl acetate. Molecular Formula: C13H21BrO4. Molecular Weight: 321.21. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Treatment Episode Data Set (TEDS): 2002-2012, State Admissions to Substance Abuse Treatment Services

This report uses data from the Treatment Episode Data Set (TEDS) to examine treatment admission data in 2012, and trend data from 2002 to 2012, nationally, regionally (by the nine Census divisions), and by state or jurisdiction. The report provides information on the demographic and substance abuse characteristics of admissions to treatment aged 12 and older for abuse of alcohol and/or drugs in facilities that report to individual state administrative data systems.
NCHS - Injury Mortality: United States

This dataset describes injury mortality in the United States beginning in 1999. Two concepts are included in the circumstances of an injury death: intent of injury and mechanism of injury. Intent of injury describes whether the injury was inflicted purposefully (intentional injury) and, if purposeful, whether the injury was self-inflicted (suicide or self-harm) or inflicted by another person (homicide). Injuries that were not purposefully inflicted are considered unintentional (accidental) injuries. Mechanism of injury describes the source of the energy transfer that resulted in physical or physiological harm to the body. Examples of mechanisms of injury include falls, motor vehicle traffic crashes, burns, poisonings, and drownings (1,2). 

Data are based on information from all resident death certificates filed in the 50 states and the District of Columbia. Age-adjusted death rates (per 100,000 standard population) are based on the 2000 U.S. standard population. Populations used for computing death rates for 2011–2015 are postcensal estimates based on the 2010 census, estimated as of July 1, 2010. Rates for census years are based on populations enumerated in the corresponding censuses. Rates for non-census years before 2010 are revised using updated intercensal population estimates and may differ from rates previously published.

Causes of injury death are classified by the International Classification of Diseases, Tenth Revision (ICD–10). Categories of injury intent and injury mechanism generally follow the categories in the external-cause-of-injury mortality matrix (1,2). Cause-of-death statistics are based on the underlying cause of death.

SOURCES

CDC/NCHS, National Vital Statistics System, mortality data (see http://www.cdc.gov/nchs/deaths.htm); and CDC WONDER (see http://wonder.cdc.gov).

REFERENCES 

1. National Center for Health Statistics. ICD–10: External cause of injury mortality matrix.

2. National Center for Health Statistics. Vital statistics data available. Mortality multiple cause files. Hyattsville, MD: National Center for Health Statistics. Available from: https://www.cdc.gov/nchs/data_access/vitalstatsonline.htm.

3. Murphy SL, Xu JQ, Kochanek KD, Curtin SC, and Arias E. Deaths: Final data for 2015. National vital statistics reports; vol 66. no. 6. Hyattsville, MD: National Center for Health Statistics. 2017. Available from: https://www.cdc.gov/nchs/data/nvsr/nvsr66/nvsr66_06.pdf.

4. Miniño AM, Anderson RN, Fingerhut LA, Boudreault MA, Warner M. Deaths: Injuries, 2002. National vital statistics reports; vol 54 no 10. Hyattsville, MD: National Center for Health Statistics. 2006.