AndreaBozzo/ceres-open-data-index huggingface dataset:
Design and intermediate results of the Lower Extremity Arterial Disease Event Reduction (LEADER)* trial of bezafibrate in men with lower extremity arterial disease [ISRCTN41194621]

Background
          Raised levels of both triglycerides and fibrinogen, each of which are reduced by bezafibrate, may contribute to lower extremity arterial disease (LEAD). This condition is characterized by a particularly high incidence of coronary heart disease (CHD) and stroke, but is little studied thus far in randomised controlled trials.
        
        
          Method
          Patients were recruited through 85 practices in the British Medical Research Council General Practice Research Framework and through nine hospital vascular clinics. The treatment regimen, which is double-blind and placebo-controlled, is bezafibrate 400 mg/day. The 1568 patients recruited represent 86% of those eligible at screening.
        
        
          Results
          None of the anticipated side effects (mainly gastrointestinal) differed between the two groups. Nearly 80% of the total person-years accrued at 3 years were spent on trial treatment. Bezafibrate significantly reduced total cholesterol by approximately 8.0% and low-density lipoprotein (LDL)-cholesterol by approximately 9.0%, and increased high-density lipoprotein (HDL)-cholesterol by approximately 11.0% initially, falling to about 6.0% at 3 years. Triglycerides were significantly reduced by about 23.0% and fibrinogen by about 14.0%. Plasma creatinine rose by approximately 11% in those on active treatment. All of these effects were highly significant (P < 0.0001). Bezafibrate had no effect on the level of C-reactive protein (CRP).
        
        
          Conclusion
          The trial recruited an unusually high proportion of eligible patients, ensuring the general applicability of its results. The fibrinogen-lowering and lipid-modifying effects of bezafibrate were confirmed. Although bezafibrate lowers fibrinogen, it has no effect on CRP; this suggests that the reduction in fibrinogen is due to an effect on its metabolism rather than suppression of an inflammatory response.
Theankgene story

A landmark investigation into the genetic basis of murine progressive ankylosis has clarified the physiologic role of extracellular inorganic pyrophosphate (ePPi) in suppressing pathologic deposition of basic calcium phosphate (BCP) (an inclusive term for hydroxyapatite, octacalcium phosphate, and tricalcium phosphate) in articular tissue [1]. A cell membrane protein, ANK, affects ePPi concentrations and the balance of mineralization in articular tissues.
Compound 527342: 1,22,26-Trimethyl-octacosyl cyanide

Chemical compound data from PubChem database. IUPAC Name: 2,23,27-trimethylnonacosanenitrile. Molecular Formula: C32H63N. Molecular Weight: 461.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Identification of critical residues in loop E in the 5-HT

Background
          The serotonin type 3 receptor (5-HT3R) is a member of a superfamily of ligand gated ion channels. All members of this family share a large degree of sequence homology and presumably significant structural similarity. A large number of studies have explored the structure-function relationships of members of this family, particularly the nicotinic and GABA receptors. This information can be utilized to gain additional insights into specific structural and functional features of other receptors in this family.
        
        
          Results
          Thirteen amino acids in the mouse 5-HT3ASR that correspond to the putative E binding loop of the nicotinic α7 receptor were chosen for mutagenesis. Due to the presence of a highly conserved glycine in this region, it has been suggested that this binding loop is comprised of a hairpin turn and may form a portion of the ligand-binding site in this ion channel family. Mutation of the conserved glycine (G147) to alanine eliminated binding of the 5-HT3R antagonist [3H]granisetron. Three tyrosine residues (Y140, Y142 and Y152) also significantly altered the binding of 5-HT3R ligands. Mutations in neighboring residues had little or no effect on binding of these ligands to the 5-HT3ASR.
        
        
          Conclusion
          Our data supports a role for the putative E-loop region of the 5-HT3R in the binding of 5-HT, mCPBG, d-tc and lerisetron. 5-HT and mCPBG interact with Y142, d-tc with Y140 and lerisetron with both Y142 and Y152. Our data also provides support for the hypothesis that this region of the receptor is present in a loop structure.
Compound 525858: N,N-Dimethyl-2-phenyl-N'-(4-nitrophenyl)-acetamidine

Chemical compound data from PubChem database. IUPAC Name: N,N-dimethyl-N'-(4-nitrophenyl)-2-phenylethanimidamide. Molecular Formula: C16H17N3O2. Molecular Weight: 283.32. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Nursing Home Cost Report (RHCF): 2009

The Nursing Home Cost Report (RHCF) is a uniform report completed by New York nursing homes to report income, expenses, assets, liabilities, and statistics to the Department of Health (DOH). Under DOH regulations, (Part 86-2.2), nursing homes are required to file financial and statistical data with DOH annually. The data filed is part of the cost report and is received electronically through a secured network. This data is used to develop Medicaid rates, assist in the formulation of reimbursement methodologies, and analyze trends. For more information, check out: http://www.health.ny.gov/facilities/nursing/ or go to the “About “ tab.
Compound 529009: 5-Bromouracil, TMS

Chemical compound data from PubChem database. IUPAC Name: (5-bromo-2-trimethylsilyloxypyrimidin-4-yl)oxy-trimethylsilane. Molecular Formula: C10H19BrN2O2Si2. Molecular Weight: 335.34. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Telomere formation on macronuclear chromosomes of

Background
          Ciliates employ massive chromatid breakage and de novo telomere formation during generation of the somatic macronucleus. Positions flanking the 81-MAC locus are reproducibly cut. But those flanking the Common Region are proposed to often escape cutting, generating three nested macronuclear chromosomes, two retaining "arms" still appended to the Common Region. Arm-distal positions must differ (in cis) from the Common Region flanks.
        
        
          Results
          The Common-Region-flanking positions also differ from the arm-distal positions in that they are "multi-TAS" regions: anchored PCR shows heterogeneous patterns of telomere addition sites, but arm-distal sites do not. The multi-TAS patterns are reproducible, but are sensitive to the sequence of the allele being processed. Thus, random degradation following chromatid cutting does not create this heterogeneity; these telomere addition sites also must be dictated by cis-acting sequences.
        
        
          Conclusions
          Most ciliates show such micro-heterogeneity in the precise positions of telomere addition sites. Telomerase is believed to be tightly associated with, and act in concert with, the chromatid-cutting nuclease: heterogeneity must be the result of intervening erosion activity. Our "weak-sites" hypothesis explains the correlation between alternative chromatid cutting at the Common Region boundaries and their multi-TAS character: when the chromatid-breakage machine encounters either a weak binding site or a weak cut site at these regions, then telomerase dissociates prematurely, leaving the new end subject to erosion by an exonuclease, which pauses at cis-acting sequences; telomerase eventually heals these resected termini. Finally, we observe TAS positioning influenced by trans-allelic interactions, reminiscent of transvection.
Compound 528578: tert-Butyl(dimethyl)silyl palmitate

Chemical compound data from PubChem database. IUPAC Name: [tert-butyl(dimethyl)silyl] hexadecanoate. Molecular Formula: C22H46O2Si. Molecular Weight: 370.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 526298: 1,4-Dibromo-7,8-dichloro-dibenzo-p-dioxin

Chemical compound data from PubChem database. IUPAC Name: 1,4-dibromo-7,8-dichlorodibenzo-p-dioxin. Molecular Formula: C12H4Br2Cl2O2. Molecular Weight: 410.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 527013: p-Tolylfentanyl

Chemical compound data from PubChem database. IUPAC Name: N-(4-methylphenyl)-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide. Molecular Formula: C23H30N2O. Molecular Weight: 350.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 530217: N-Methyl nicotinimidate, O-trimethylsilyl

Chemical compound data from PubChem database. IUPAC Name: trimethylsilyl N-methylpyridine-3-carboximidate. Molecular Formula: C10H16N2OSi. Molecular Weight: 208.33. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Cloning and expression of the rabbit prostaglandin EP2 receptor

Background
          Prostaglandin E2 (PGE2) has multiple physiologic roles mediated by G protein coupled receptors designated E-prostanoid, or "EP" receptors. Evidence supports an important role for the EP2 receptor in regulating fertility, vascular tone and renal function.
        
        
          Results
          The full-length rabbit EP2 receptor cDNA was cloned. The encoded polypeptide contains 361 amino acid residues with seven hydrophobic domains. COS-1 cells expressing the cloned rabbit EP2 exhibited specific [3H]PGE2 binding with a Kd of 19.1± 1.7 nM. [3H]PGE2 was displaced by unlabeled ligands in the following order: PGE2>>PGD2=PGF2α=iloprost. Binding of [3H]PGE2 was also displaced by EP receptor subtype selective agonists with a rank order of affinity consistent with the EP2 receptor (butaprost>AH13205>misoprostol>sulprostone). Butaprost free acid produced a concentration-dependent increase in cAMP accumulation in rabbit EP2 transfected COS-1 cells with a half-maximal effective concentration of 480 nM. RNase protection assay revealed high expression in the ileum, spleen, and liver with lower expression in the kidney, lung, heart, uterus, adrenal gland and skeletal muscle. In situ hybridization localized EP2 mRNA to the uterine endometrium, but showed no distinct localization in the kidney. EP2 mRNA expression along the nephron was determined by RT-PCR and its expression was present in glomeruli, MCD, tDL and CCD. In cultured cells EP2 receptor was not detected in collecting ducts but was detected in renal interstitial cells and vascular smooth muscle cells. EP2 mRNA was also detected in arteries, veins, and preglomerular vessels of the kidney.
        
        
          Conclusion
          EP2 expression pattern is consistent with the known functional roles for cAMP coupled PGE2 effects in reproductive and vascular tissues and renal interstitial cells. It remains uncertain whether it is also expressed in renal tubules.
Child Maltreatment 2023

This report presents national data about child abuse and neglect known to child protective services agencies in the United States during federal fiscal year 2023.

Letter from the Commissioner

Acknowledgements

Summary

CHAPTER 1: Introduction

CHAPTER 2: Reports

CHAPTER 3: Children

CHAPTER 4: Fatalities

CHAPTER 5: Perpetrators

CHAPTER 6: Services

APPENDIX A: CAPTA Data Items

APPENDIX B: Glossary

APPENDIX C: State Characteristics

APPENDIX D: State Commentary

Metadata-only record linking to the original dataset. Open original dataset below.
CDC WONDER: Population (from Census)

<p>The Population online databases  contain data from the US Census Bureau.  The Census Estimates online database contains contains county-level population counts for years 1970 - 2000.  The data comprise the April 1st Census counts for years 1970, 1980, 1990 and 2000, the July 1st intercensal estimates for years 1971-1979 and 1981-1989, and the July 1st postcensal estimates for years 1991-1999.  The Census Projections online database contains population projections for years 2004-2030 by year, state, age, race and sex,  prodyced by teh Cenus Bureau in 2005. The data are produced by the United States Department of Commerce, U.S. Census Bureau, Population Division.</p>
Compound 528147: 5-Sec-butyl-3-methyl-2-methoxypyrazine

Chemical compound data from PubChem database. IUPAC Name: 5-butan-2-yl-2-methoxy-3-methylpyrazine. Molecular Formula: C10H16N2O. Molecular Weight: 180.25. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
2010 CMHS Uniform Reporting System (URS) Output Tables for Michigan

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
Stable hepatitis C virus RNA detection by RT-PCR during four days storage

Background
          Suboptimal specimen processing and storage conditions of samples which contain hepatitis C virus (HCV) RNA may result in a decline of HCV RNA concentration or false-negative results in the detection of HCV RNA in serum. We evaluated the stability of HCV RNA in serum and clotted blood samples stored at room temperature or at 4°C for 4 days with the aim of optimizing the standard procedures of processing and storage of samples.
        
        
          Methods
          Blood from five HCV RNA positive patients was collected in tubes with and without separator gel, centrifuged 1 or 6 hours after collection. Samples were then left 6, 24, 48, 72 or 96 h at room temperature (21.5 – 25.4°C) or at 4°C before determining their HCV RNA level using the COBAS AMPLICOR HCV MONITOR Test, vs 2.0 (Roche Diagnostic Systems).
        
        
          Results
          The logarithm of the HCV RNA level measurements remained within a 0.3 value of the means for 4 days at both temperatures (room temperature or 4°C).
        
        
          Conclusions
          We conclude that blood samples may be collected and aliquoted within 6 h of collection and can be stored at 4°C for 72 hours as proposed by the manufacturer without significant differences in measured HCV RNA level. Our results indicate that lapses in this scheme may still yield reliable results.
Project Outcomes Assessment Survey

The information collected by the Project Outcome Assessment Survey (POAS) is needed for two main reasons: 1) to collect crucial information required to report on the Administration for Native Americans' (ANA) established Government Performance and Results Act (GPRA) measures, and 2) to properly abide by ANA's congressionally-mandated statute (42 United States Code 2992 et seq.) found under the section titled ‘Evaluation’ in the Native American Programs Act of 1974, as amended, which states that ANA will evaluate projects assisted through ANA grant dollars “including evaluations that describe and measure the impact of such projects, their effectiveness in achieving stated goals, their impact on related programs, and their structure and mechanisms for delivery of services.” The information collected with this survey will fulfill ANA's statutory requirement. Revisions are required as ANA removed several questions it deems superfluous and not reviewed by analysts. This allows for more in depth qualitative questions to be added, as well as clarifying some remaining questions which were ambiguous. The Native American Programs Act of 1974 states under the section titled Evaluation that, “the projects assisted under this title shall be evaluated in accordance with this section not less frequently than at 3-year intervals.” ANA assesses at least one-third of its grant portfolio each year to meet the assigned mandate. This mandate eliminates the need to use sampling methods as all ANA projects 
will be evaluated over a three-year period. The latest form for Project Outcomes Assessment Survey expires 2022-06-30.

Respondents are Tribal Governments, Native American nonprofit organizations, and Tribal Colleges and Universities.

<b>Units of Response: </b>Grantee

<b>Type of Data: </b>Survey

<b>Tribal Data: </b>Yes

<b>COVID-19 Data: </b>Unavailable

<b>Periodicity: </b>Unavailable

<b>SORN: </b>https://www.federalregister.gov/documents/2022/02/08/2022-02535/privacy-act-of-1974-system-of-records

<b>Data Use Agreement: </b>Not Applicable

<b>Data Use Agreement Location: </b>Unavailable

<b>Equity Indicators: </b>Ethnicity;Indigenous Population;Race

<b>Granularity: </b>Grant;Grantee

<b>Spatial: </b>United States

<b>Geocoding: </b>Region;State
Patent AT-E400914-T1: [Translated] FULLY TRANSPOSED HIGH-T C? COMPOSITE SUPERCONDUCTOR AND DEVICE FOR THE PRODUCTION AND USE THEREOF

The invention relates to a fully transposed composite superconductor (2) that can be especially used for AD devices and that contains subconductors (3j) composed according to the Roebel bar principle and containing high Tc superconducting material. The aim of the invention is to provide subconductors, that can be laterally bent in the plane of their width B so that the bending radius R is more than 100 times the width B and the bending zone length H is more than 20 times the width B. The inventive device for producing the conductor (2) comprises means disposed in series for combining, bending, assembling to a Roebel bar, and fixating the subconductors.
Compound 525140: Decyl pentyl phthalate

Chemical compound data from PubChem database. IUPAC Name: 2-O-octyl 1-O-pentyl benzene-1,2-dicarboxylate. Molecular Formula: C21H32O4. Molecular Weight: 348.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 529134: 2-Chloro-N-(5-cyano-2-imino-3-phenyl-2,3-dihydro-1,3-thiazol-4-yl)acetamide

Chemical compound data from PubChem database. IUPAC Name: N-[tert-butyl(dimethyl)silyl]-4-[tert-butyl(dimethyl)silyl]oxybutan-1-amine. Molecular Formula: C16H39NOSi2. Molecular Weight: 317.66. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
2022-2023 NSDUH: State-Specific Tables

Browse population estimates based on the 2022-2023 National Surveys on Drug Use and Health (NSDUH) for each state and region. There are four tables for each geographic area, which present population estimates and percentages for 38 measures of substance use and mental health by age group. These estimates are based on small area estimation (SAE) methods in which state-level NSDUH data are combined with other data from smaller geographies. The combined data are used to create modeled state estimates of the civilian, noninstitutionalized population ages 12 and older (or adults 18 and older for mental health measures).The tables are available in a zip file of PDFs or as an HTML file. There is also a table of contents which contains links to specific state files in HTML or PDF.Tables labeled with an A include measures of substance use and perceptions of substance use. Tables labeled with a B include measures of substance use disorder and treatment, and mental health measures.
Inhaled nitric oxide in acute respiratory distress syndrome with and without septic shock requiring norepinephrine administration: a dose–response study

Background:
          The aim of this prospective study was to assess whether the presence of septic shock could influence the dose response to inhaled nitric oxide (NO) in NO-responding patients with adult respiratory distress syndrome (ARDS).
        
        
          Results:
          Eight patients with ARDS and without septic shock (PaO2 = 95 ± 16 mmHg, PEEP = 0, FiO2 = 1.0), and eight patients with ARDS and septic shock (PaO2 = 88 ± 11 mmHg, PEEP = 0, FiO2 = 1.0) receiving exclusively norepinephrine were studied. All responded to 15 ppm inhaled NO with an increase in PaO2 of at least 40 mmHg, at FiO2 1.0 and PEEP 10 cmH2O. Inspiratory intratracheal NO concentrations were recorded continuously using a fast response time chemiluminescence apparatus. Seven inspiratory NO concentrations were randomly administered: 0.15, 0.45, 1.5, 4.5, 15, 45 and 150 ppm. In both groups, NO induced a dose-dependent decrease in mean pulmonary artery pressure (MPAP), pulmonary vascular resistance index (PVRI), and venous admixture (QVA/QT), and a dose-dependent increase in PaO2/FiO2 (P ≤ 0.012). Dose-response of MPAP and PVRI were similar in both groups with a plateau effect at 4.5 ppm. Dose-response of PaO2/FiO2 was influenced by the presence of septic shock. No plateau effect was observed in patients with septic shock and PaO2/FiO2 increased by 173 ± 37% at 150 ppm. In patients without septic shock, an 82 ± 26% increase in PaO2/FiO2 was observed with a plateau effect obtained at 15 ppm. In both groups, dose-response curves demonstrated a marked interindividual variability and in five patients pulmonary vascular effect and improvement in arterial oxygenation were dissociated.
        
        
          Conclusion:
          For similar NOinduced decreases in MPAP and PVRI in both groups, the increase in arterial oxygenation was more marked in patients with septic shock.
Effects of whole-body vibration on reproductive physiology in a rat model

Workers in a number of sectors including Transportation, Warehousing and Utilities, Construction, Agriculture, Forestry’s and Fisheries and Mining are regularly exposed to whole-body vibration (WBV) while driving large transportation or earth moving vehicles or while using large vibrating tools such as chain saws or rock drills.  Exposure to WBV has been associated with an increased risk for neck and back pain.  However, the findings of other studies have suggested that occupational exposure to WBV may also serve as a risk factor for the development of a number of diseases such as cardiovascular disease and cancer.  In addition, it may result in pre-term births and preclampsia in women and interfere with normal reproductive physiology in both men and women.