AndreaBozzo/ceres-open-data-index huggingface dataset:
Subunit modification and association in VR1 ion channels

Background
          The capsaicin (vanilloid) receptor, VR1, is an agonist-activated ion channel expressed by sensory neurons that serves as a detector of chemical and thermal noxious stimuli.
        
        
          Results
          In the present study we investigated the properties of VR1 ion channels expressed in Xenopus oocytes. A VR1 subunit with a FLAG epitope tag at the C-terminus was constructed. When examined for size on an SDS gel, VR1-expressing oocytes produced a doublet corresponding to the size of the monomer and a band at about twice the molecular weight of the monomer. A consensus site for N-linked glycosylation was identified in the primary sequence at position 604. In channels in which the putative glycosylation site was mutated from asparagine to serine (N604S), the larger of the two monomer bands could no longer be detected on the gel. Electrophysiological experiments showed these unglycosylated channels to be functional. The high molecular weight band observed on the gel could represent either a dimer or a monomer conjugated to an unknown factor. To distinguish between these possibilities, we coexpressed a truncated VR1 subunit with full-length VR1. A band of intermediate molecular weight (composed of one full-length and one truncated subunit) was observed. This dimer persisted under strongly reducing conditions, was not affected by capsaicin or calcium, and was refractory to treatment with transglutaminase inhibitors.
        
        
          Conclusions
          The persistence of this dimer even under harsh denaturing and reducing conditions indicates a strong interaction among pairs of subunits. This biochemical dimerization is particularly intriguing given that functional channels are almost certainly tetramers.
Bismuth subcitrate potassium, metronidazole and tetracycline hydrochloride

This is a prescription medication combining bismuth subcitrate potassium (140 mg), metronidazole (125 mg), and tetracycline hydrochloride (125 mg) in oral capsules. It's used to treat certain bacterial infections, like those caused by H. pylori. Manufactured by Endo USA, Inc., under ANDA 205770. This information was generated using AI and is provided for informational and research purposes only.
Patent AT-E400956-T1: [Translated] METHOD AND DEVICE FOR REDUCING AMPLITUDE Fluctuations AND INTERFERENCES IN COMMUNICATION SIGNALS USING PILOT SYMBOLS

Chemical patent from PubChem database. Patent Number: AT-E400956-T1. Title: Method of Treatment Using Chemical Compounds. Filing Date: 2002-08-19. Inventors: Garcia, Maria, Miller, Thomas. Abstract: Methods for treating diseases using specific chemical compounds are provided, including dosing regimens and combination therapies for enhanced therape... IPC Classifications: A61K, A61P, C07D. This patent covers 29 claims related to 5 chemical compounds. Useful for intellectual property research, prior art searches, and chemical innovation tracking.
Patent AT-E400341-T1: [Translated] TWO-PIECE HOLDER FOR BARS OF JUMPING OBSTACLES AND PRODUCTION PROCESS THEREOF

A two part support for the bar in an equestrian fence, e.g. for show jumping, has a two part construction with an adaptor (35) provided with two rear fitting studs (45, 47) to fit into one of an array of holes in an upright and with a bar support (11) fitted into a slot in the front of the adaptor using two studs. The fitting includes a sprung grip to hold the two components together. The bar is displaced from the support by horizontal forces and the bar support is released from the adaptor by vertical forces. The two part support can be made of plastic mouldings.
ONC Health Information Technology for Economic and Clinical Health (HITECH) Grantee List

The Health Information Technology for Economic and Clinical Health (HITECH) Act was passed as part of the American Recovery and Reinvestment Act (ARRA) to invest in the U.S. health IT infrastructure. The Office of the National Coordinator for Health IT (ONC) received over $2 billion of these HITECH funds, which was granted to health and community organizations across the U.S. This data set provides the full list of ONC's HITECH Act grantees. The data encompasses the five ONC HITECH Act programs: the Beacon Communities Program, the Health IT Regional Extension Centers Program, the Health IT Workforce Programs, the State Health Information Exchange Program, and the Strategic Health IT Advanced Research Projects (SHARP) Program. This data set includes geographic, federal funding, and grantee organization data. The data can be linked to other open data sets on the Health IT Dashboard and other sources.
Compound 529730: Dimethyl 1-bromoethylmalonate

Chemical compound data from PubChem database. IUPAC Name: dimethyl 2-(1-bromoethyl)propanedioate. Molecular Formula: C7H11BrO4. Molecular Weight: 239.06. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528881: Octopamine, N-acetyl-PFP

Chemical compound data from PubChem database. IUPAC Name: [4-[2-acetamido-1-(2,2,3,3,3-pentafluoropropanoyloxy)ethyl]phenyl] 2,2,3,3,3-pentafluoropropanoate. Molecular Formula: C16H11F10NO5. Molecular Weight: 487.25. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
2015 CMHS Uniform Reporting System (URS) Table for Rhode Island

2015 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Rhode Island. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
Compound 527124: 1,4-Dichloro-dibenzothiophene

Chemical compound data from PubChem database. IUPAC Name: 1,4-dichlorodibenzothiophene. Molecular Formula: C12H6Cl2S. Molecular Weight: 253.1. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Factors associated with home death for individuals who receive home support services: a retrospective cohort study

Objectives
          To determine the factors associated with a home death among older adults who received palliative care nursing home services in the home.
        
        
          Methods
          The participants in this retrospective cohort study were 151 family caregivers of patients who had died approximately 9 months prior to the study telephone interview. The interview focused on the last year of life and covered two main areas, patient characteristics and informal caregiver characteristics.
        
        
          Results
          Odds ratios [OR] and 95% confidence intervals [95% CI] were used to determine which of the 15 potential informal caregiver and seven patient predictor variables were associated with dying at home. Multivariate analysis revealed that the odds of dying at home were greater when the patient lived with a caregiver [OR = 7.85; 95% CI = (2.35, 26.27)], the patient stated a preference to die at home [OR= 6.51; 95% CI = (2.66,15.95)], and the family physician made home visits [OR = 4.79; 95% CI = (1.97,11.64)]. However the odds were lower for patients who had caregivers with fair to poor health status [OR = 0.22; 95% CI = (0.07, 0.65)] and for patients who used hospital palliative care beds [OR = 0.31; 95% CI = (0.12, 0.80)].
        
        
          Discussion
          The findings suggest that individuals who indicated a preference to die at home and resided with a healthy informal caregiver had better odds of dying at home. Home visits by a family physician were also associated with dying at home.
Compound 529046: Ethanediol, hexylboronate

Chemical compound data from PubChem database. IUPAC Name: 2-hexyl-1,3,2-dithiaborolane. Molecular Formula: C8H17BS2. Molecular Weight: 188.2. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 525840: N,N-Dimethyl-N'-heptyl-propionamidine

Chemical compound data from PubChem database. IUPAC Name: N'-heptyl-N,N-dimethylpropanimidamide. Molecular Formula: C12H26N2. Molecular Weight: 198.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
MeSH 2023 Publication Types

Publication Types (Publication Characteristics) are Descriptors that indicate what an indexed item is, (i.e., its genre, rather than what it is about - for example, Historical Article). They may include Publication Components, such as Charts; Publication Formats, such as Editorial; and Study Characteristics, such as Clinical Trial.

They function as metadata, rather than being about the content. These records are searchable in PubMed as Publication Type [PT], and the terms in MEDLINE records are labeled as "PT" or <PublicationType> rather than "MH" or <MeSHHeading>. They are listed in category V of the MeSH Tree Structures.
Making a Difference for Public Child Welfare Agencies: Key Findings From the Final Evaluation Report: Fiscal Years 2015–2019

In 2014, the Children’s Bureau established the Child Welfare Capacity Building Collaborative consisting of the Center for States, Center for Tribes, and Center for Courts. The Collaborative works with child welfare professionals and their jurisdictions to build organizational capacity and help agencies and courts improve their effectiveness. The Center for States builds capacity within public child welfare agencies to help strengthen organizational performance and improve outcomes for children, youth, and families.

Metadata-only record linking to the original dataset. Open original dataset below.
Endemic and epidemic dynamics of cholera: the role of the aquatic reservoir

Background
          In the last decades, attention to cholera epidemiology increased, as cholera epidemics became a worldwide health problem. Detailed investigation of V. cholerae interactions with its host and with other organisms in the environment suggests that cholera dynamics is much more complex than previously thought. Here, I formulate a mathematical model of cholera epidemiology that incorporates an environmental reservoir of V. cholerae. The objective is to explore the role of the aquatic reservoir on the persistence of endemic cholera as well as to define minimum conditions for the development of epidemic and endemic cholera.
        
        
          Results
          The reproduction rate of cholera in a community is defined by the product of social and environmental factors. The importance of the aquatic reservoir depends on the sanitary conditions of the community. Seasonal variations of contact rates force a cyclical pattern of cholera outbreaks, as observed in some cholera-endemic communities.
        
        
          Conclusions
          Further development on cholera modeling requires a better understanding of V. cholerae ecology and epidemiology. We need estimates of the prevalence of V. cholerae infection in endemic populations as well as a better description of the relationship between dose and virulence.
Compound 525256: 2-Cyclohexyl-1,1,3,3-tetramethylguanidine

Chemical compound data from PubChem database. IUPAC Name: 2-cyclohexyl-1,1,3,3-tetramethylguanidine. Molecular Formula: C11H23N3. Molecular Weight: 197.32. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
NNDSS - Table II. Rabies, animal to Rubella, congenital syndrome

NNDSS - Table II. Rabies, animal to Rubella, congenital syndrome - 2017.  In this Table, provisional cases of selected notifiable diseases (≥1,000 cases reported during the preceding year), and selected low frequency diseases are displayed.  The Table includes total number of cases reported in the United States, by region and by states, in accordance with the current method of displaying MMWR data.  Data on United States exclude counts from US territories.

Note:
These are provisional cases of selected national notifiable diseases, from the National Notifiable Diseases Surveillance System (NNDSS). NNDSS data reported by the 50 states, New York City, the District of Columbia, and the U.S. territories are collated and published weekly as numbered tables printed in the back of the Morbidity and Mortality Weekly Report (MMWR). Cases reported by state health departments to CDC for weekly publication are provisional because of ongoing revision of information and delayed reporting. 

Case counts in this table are presented as they were published in the MMWR issues. Therefore, numbers listed in later MMWR weeks may reflect changes made to these counts as additional information becomes available. 

Footnotes:
 C.N.M.I.: Commonwealth of Northern Mariana Islands. 

 U: Unavailable. —: No reported cases. N: Not reportable. NN: Not Nationally Notifiable. NP: Nationally notifiable but not published. Cum: Cumulative year-to-date counts. Med: Median. Max: Maximum. 

*Three low incidence conditions, rubella, rubella congenital, and tetanus, are in Table II to facilitate case count verification with reporting jurisdictions. 

† Case counts for reporting year 2017 are provisional and subject to change. For further information on interpretation of these data, see http://wwwn.cdc.gov/nndss/document/ ProvisionalNationaNotifiableDiseasesSurveillanceData20100927.pdf. Data for tuberculosis are displayed in Table IV, which appears quarterly.
Compound 529108: 4-Quinazolone, 2-butyl-3-methyl

Chemical compound data from PubChem database. IUPAC Name: 2-butyl-3-methylquinazolin-4-one. Molecular Formula: C13H16N2O. Molecular Weight: 216.28. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E401357-T1: [Translated] POLYETHYLENE RESIN WITH Narrow grain size distribution

The present invention relates to a polyethylene resin comprising nA) a first ethylene homo- or copolymer fraction, and nB) a second ethylene homo- or copolymer fraction,  nwherein fraction (A) has a lower molecular weight than fraction (B), characterized in that the polymer resin powder obtained directly after the final polymerisation step has a particle size distribution PSD 95/5  equal to or smaller than 12.  Furthermore, the invention relates to a process for the production of a polymer composition comprising: n(i) a step in which ethylene monomers, and optionally further alpha-olefin-comonomers, are polymerised in liquid phase in the presence of a polymerisation catalyst, n(ii) a step in which ethylene monomers, and optionally further alpha-olefin comonomers, are polymerised in the gas phase in the presence of a polymerisation catalyst, and n(iii) obtaining a polymer resin powder after the final polymerisation step wherein the powder has a particle size distribution PSD 95/5  equal to or smaller than 12.
Supporting Evidence-Based Home Visitation Programs to Prevent Child Abuse and Neglect Project: Children and Families First Delaware, Inc.

Location:

Statewide

Home Visiting Program Selected:

Nurse Family Partnership

Home Visiting Target Population:

Low-income first-time pregnant mothers with risk factors associated with child maltreatment comprise the target population

Project Overview:
Children & Families First, a non-profit, statewide human service agency, in collaboration with a variety of public– and private–sector agencies, will lead Delaware's plan to coordinate existing home visitation programs and to implement Nurse Family Partnership Program (NFP). The first project goal is to lead a comprehensive community planning process to build local capacity to support improved home visit quality. The second goal is to implement NFP through a phased-in approach beginning with a team of four Nurse Home Visitors, which will then be expanded to statewide by adding home visitors in two additional counties. In these two counties, Delaware will add mental health consultation services to address the limited mental health resources in those communities. Children and Families First will evaluate their efforts through a process evaluation and cost analysis.

Metadata-only record linking to the original dataset. Open original dataset below.
Profile of Enrolled Medi-Cal Dental Fee-for-Service (FFS) Providers and Safety Net Clinics (SNCs)

The dataset provides enrollment and geographic data for Fee-for-Service (FFS) providers enrolled in the Medi-Cal Dental program and Safety Net Clinics (SNCs) who provide dental services. The data is based on a point in time and is expected to be updated biannually. The enrollment and SNC data is as of June 2024. This dataset does not include Dental Managed Care providers.
Compound 526520: 2-O-cyclohexyl 1-O-tridecyl benzene-1,2-dicarboxylate

Chemical compound data from PubChem database. IUPAC Name: 2-O-cyclohexyl 1-O-tridecyl benzene-1,2-dicarboxylate. Molecular Formula: C27H42O4. Molecular Weight: 430.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 526965: bis-(4-Nitrophenyl)acetic acid, methyl ester

Chemical compound data from PubChem database. IUPAC Name: methyl 2,2-bis(4-nitrophenyl)acetate. Molecular Formula: C15H12N2O6. Molecular Weight: 316.26. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Retroviral vectors for establishing tetracycline-regulated gene expression in an otherwise recalcitrant cell line

Background
          Tetracycline-regulated systems have been used to control the expression of heterologous genes in such diverse organisms as yeast, plants, flies and mice. Adaptation of this prokaryotic regulatory system avoids many of the problems inherent in other inducible systems. There have, however, been many reports of difficulties in establishing functioning stable cell lines due to the cytotoxic effects of expressing high levels of the tetracycline transactivator, tTA, from a strong viral promoter.
        
        
          Results
          Here we report the successful incorporation of tetracycline-mediated gene expression in a mouse mammary epithelial cell line, HC11, in which conventional approaches failed. We generated retroviruses in which tTA expression was controlled by one of three promoters: a synthetic tetracycline responsive promoter (TRE), the elongation factor 1-alpha promoter (EF1α) or the phosphoglycerate kinase-1 promoter (PGK), and compared the resulting cell lines to one generated using a cytomegalovirus immediate early gene promoter (CMV). In contrast to cells produced using the CMV and PGK promoters, those produced using the EF1α and TRE promoters expressed high levels of β-galactosidase in a tetracycline-dependent manner.
        
        
          Conclusions
          These novel retroviral vectors performed better than the commercially available system and may have a more general utility in similarly recalcitrant cell lines.
New Mexico (NM)

This report uses 2008 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past year alcohol use disorder and illicit drug use disorder among persons aged 12 or older for New Mexico overall and for substate regions within New Mexico. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE).
Suicidal Thoughts and Behavior among Adults: Results from the 2015 National Survey on Drug Use and Health

This report presents estimates for suicidal thoughts, plans, and non-fatal attempts from the 2015 National Survey on Drug Use and Health (NSDUH) for adults aged 18 or older. Estimates are also included of those that had suicidal thoughts, their percentage of illicit drug use, substance use disorders, and major depressive episode.  Comparisons are made by sex and by age group.  Trends are examined between 2014 and 2014 and in some cases, 2008 and 2015.
NNDSS - TABLE 1X. Meningococcal disease,  Other serogroups to Meningococcal disease, Unknown serogroup

NNDSS - TABLE 1X. Meningococcal disease,  Other serogroups to Meningococcal disease, Unknown serogroup - 2019. In this Table, provisional cases* of notifiable diseases are displayed for United States, U.S. territories, and Non-U.S. residents. 

Note: 
This table contains provisional cases of national notifiable diseases from the National Notifiable Diseases Surveillance System (NNDSS). NNDSS data from the 50 states, New York City, the District of Columbia and the U.S. territories are collated and published weekly on the NNDSS Data and Statistics web page (https://wwwn.cdc.gov/nndss/data-and-statistics.html). Cases reported by state health departments to CDC for weekly publication are provisional because of the time needed to complete case follow-up. Therefore, numbers presented in later weeks may reflect changes made to these counts as additional information becomes available. The national surveillance case definitions used to define a case are available on the NNDSS web site at https://wwwn.cdc.gov/nndss/. Information about the weekly provisional data and guides to interpreting data are available at: https://wwwn.cdc.gov/nndss/infectious-tables.html. 

Footnotes:
U: Unavailable — The reporting jurisdiction was unable to send the data to CDC or CDC was unable to process the data.
-: No reported cases — The reporting jurisdiction did not submit any cases to CDC.
N: Not reportable — The disease or condition was not reportable by law, statute, or regulation in the reporting jurisdiction.
NN: Not nationally notifiable — This condition was not designated as being nationally notifiable.
NP: Nationally notifiable but not published — CDC does not have data because of changes in how conditions are categorized.
Cum: Cumulative year-to-date counts.
Max: Maximum — Maximum case count during the previous 52 weeks.
* Case counts for reporting years 2018 and 2019 are provisional and subject to change. Cases are assigned to the reporting jurisdiction submitting the case to NNDSS, if the case's country of usual residence is the US, a US territory, unknown, or null (i.e. country not reported); otherwise, the case is assigned to the 'Non-US Residents' category. For further information on interpretation of these data, see https://wwwn.cdc.gov/nndss/document/Users_guide_WONDER_tables_cleared_final.pdf. 
† Previous 52 week maximum and cumulative YTD are determined from periods of time when the condition was reportable in the jurisdiction (i.e., may be less than 52 weeks of data or incomplete YTD data).
Compound 530678: Phenylacetic acid, tridec-2-ynyl ester

Chemical compound data from PubChem database. IUPAC Name: tridec-2-ynyl 2-phenylacetate. Molecular Formula: C21H30O2. Molecular Weight: 314.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.