AndreaBozzo/ceres-open-data-index huggingface dataset:
Fibroblast biology: Effector signals released by the synovial fibroblast in arthritis

There is mounting evidence indicating that the synovial fibroblast is a direct effector of tissue injury and matrix remodeling in inflammatory synovitis. Through the elaboration of effector signals including cytokines and chemokines, mesenchymal cells stimulate or suppress inflammation via autocrine and paracrine mechanisms. Synovial fibroblasts are the principal cells mediating joint destruction through secretion of metalloproteinases, and recent evidence suggests that they may also promote bone resorption by stimulating osteoclastogenesis. Moreover, they may play an integral role in the initial phases of synovitis by releasing chemokines that recruit leukocytes to the joint, and cytokines that trigger angiogenesis. Studies focusing on synoviocyte-leukocyte interactions mediated via the cytokine network and the role of cell-cell contact in driving synoviocyte activation will help define the complex interplay that leads to the initiation and perpetuation of synovial inflammation.
Compound 525240: N''-(3-fluoro-phenyl)-N,N,N',N'-tetramethyl-guanidine

Chemical compound data from PubChem database. IUPAC Name: 2-(3-fluorophenyl)-1,1,3,3-tetramethylguanidine. Molecular Formula: C11H16FN3. Molecular Weight: 209.26. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Molecular cloning and sequence analysis of hamster CENP-A cDNA

Background
          The centromere is a specialized locus that mediates chromosome movement during mitosis and meiosis. This chromosomal domain comprises a uniquely packaged form of heterochromatin that acts as a nucleus for the assembly of the kinetochore a trilaminar proteinaceous structure on the surface of each chromatid at the primary constriction. Kinetochores mediate interactions with the spindle fibers of the mitotic apparatus. Centromere protein A (CENP-A) is a histone H3-like protein specifically located to the inner plate of kinetochore at active centromeres. CENP-A works as a component of specialized nucleosomes at centromeres bound to arrays of repeat satellite DNA.
        
        
          Results
          We have cloned the hamster homologue of human and mouse CENP-A. The cDNA isolated was found to contain an open reading frame encoding a polypeptide consisting of 129 amino acid residues with a C-terminal histone fold domain highly homologous to those of CENP-A and H3 sequences previously released. However, significant sequence divergence was found at the N-terminal region of hamster CENP-A that is five and eleven residues shorter than those of mouse and human respectively. Further, a human serine 7 residue, a target site for Aurora B kinase phosphorylation involved in the mechanism of cytokinesis, was not found in the hamster protein. A human autoepitope at the N-terminal region of CENP-A described in autoinmune diseases is not conserved in the hamster protein.
        
        
          Conclusions
          We have cloned the hamster cDNA for the centromeric protein CENP-A. Significant differences on protein sequence were found at the N-terminal tail of hamster CENP-A in comparison with that of human and mouse. Our results show a high degree of evolutionary divergence of kinetochore CENP-A proteins in mammals. This is related to the high diverse nucleotide repeat sequences found at the centromere DNA among species and support a current centromere model for kinetochore function and structural plasticity.
Localities for 2012B

Physician Fee Schedule - March 2012 release. This file contains the revisions identified in the Middle Class Tax Relief and Job Creation Act of 2012 (MCTRJCA). Medicare payment rates under the Medicare Physician Fee Schedule (MPFS) are set according to statutory criteria. The following 2012 MPFS payment rates are reflective of the CY 2012 Medicare Physician Fee Schedule Final Rule, which was published in the Federal Register on November 28, 2011, and the CY 2012 Medicare Physician Fee Schedule Final Rule Correction Notice, which was published in the Federal Register on January 4, 2012. These payment rates are based on current law, including the Middle Class Tax Relief and Job Creation Act of 2012 (MCTRJCA), which provides for a zero percent update through December 31, 2012. The MCTRJCA extends several provisions of the Temporary Payroll Tax Cut Continuation Act of 2011 (TPTCCA). Please note that MCTRJCA does NOT extend add-on payments for mental health services and minimum payment for bone mass measurement (sections 307 and 309 of the TPTCCA, respectively). As such, effective March 1, 2012, the MPFS payment rates for these services have changed. 2012A: Medicare payment rates under the Medicare Physician Fee Schedule (MPFS) are set according to statutory criteria. The following 2012 MPFS payment rates are reflective of the CY 2012 Medicare Physician Fee Schedule Final Rule, which was published in the Federal Register on November 28, 2011, and the CY 2012 Medicare Physician Fee Schedule Final Rule Correction Notice that was put on display at the Office of the Federal Register on December 30, 2011. These payment rates are based on current law, including the Temporary Payroll Tax Cut Continuation Act of 2011, which provides for a zero percent update for the period of January 1, 2012 to February 29, 2012. The Centers for Medicare and Medicaid Services will work quickly to update MPFS payment rates in the event Congress passes legislation to prevent the negative update from going into effect on March 1, 2012. Please be on the alert for more information about the 2012 physician update as it becomes available.
Compound 530765: m-Methoxybenzoic acid, 5-fluoro-2-nitrophenyl ester

Chemical compound data from PubChem database. IUPAC Name: (5-fluoro-2-nitrophenyl) 3-methoxybenzoate. Molecular Formula: C14H10FNO5. Molecular Weight: 291.23. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 527804: 2,2-Dichloroethyl 3-chlorobenzoate

Chemical compound data from PubChem database. IUPAC Name: 2,2-dichloroethyl 3-chlorobenzoate. Molecular Formula: C9H7Cl3O2. Molecular Weight: 253.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
National Survey of Substance Abuse Treatment Services (N-SSATS-2003)

<p>The National Survey of Substance Abuse Treatment Services (N-SSATS) is designed to collect information from all facilities in the United States, both public and private, that provide substance abuse treatment. N-SSATS provides the mechanism for quantifying the dynamic character and composition of the United States substance abuse treatment delivery system. The objectives of N-SSATS are to collect multipurpose data that can be used to assist the Substance Abuse and Mental Health Services Administration (SAMHSA) and state and local governments in assessing the nature and extent of services provided and in forecasting treatment resource requirements, update SAMHSA's Inventory of Substance Abuse Treatment Services (I-SATS), analyze general treatment services trends, and generate the National Directory of Drug and Alcohol Abuse Treatment Programs and its online equivalent, the Substance Abuse Treatment Facility Locator <a href="http://findtreatment.samhsa.gov">http://findtreatment.samhsa.gov</a>.<br />
Data are collected on topics including facility operation, services offered (assessment, substance abuse therapy and counseling, pharmacotherapies, testing, transitional, ancillary), primary focus (substance abuse, mental health, both, general health, other), hotline operation, Opioid Treatment Programs and medication dispensed, languages in which treatment is provided, type of treatment provided, number of clients (total and under age 18), number of beds, types of payment accepted, sliding fee scale, special programs offered, facility accreditation and licensure/certification, and managed care agreements.This study has 1 Data Set.</p>
Table 9. Alcohol Use in the Past Month among Persons Aged 12 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2008, 2009, and 2010 NSDUHs

This table presents the 2008 to 2010 National Survey on Drug Use and Health (NSDUH) estimates of past month alcohol use by those aged 12 or older by State and substate regions.
Compound 530422: 4-Carene, (1S,3R,6R)-(-)-

Chemical compound data from PubChem database. IUPAC Name: 4,7,7-trimethylbicyclo[4.1.0]hept-2-ene. Molecular Formula: C10H16. Molecular Weight: 136.23. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E400384-T1: [Translated] METHOD AND DEVICE FOR CLOSING THE SPOUT OPENING OF A METALLURGICAL VESSEL

A method of preparing for a filling cycle and subsequent casting of molten metal a ladle comprising a casting channel closed by a plugging valve and comprising the steps of: n- opening the valve, n- inserting from the outside a deformable shell (16a) provided with an opening through the open valve (14) inside the casting channel (27) with the opening turned towards the valve and with said shell having a maximum volume not less than that of the casting channel, n- injecting from the outside a refractory substance with fluid behavior through the opening in the shell (16a) to swell it and cause adherence of the walls of the shell to the channel wall (27), and n- closing the valve (14).
Ohio AFCARS Assessment Review

This webpage includes the documentation from Ohio's Adoption and Foster Care Analysis and Reporting System (AFCARS) assessment review for fiscal year 2012:

AFCARS Assessment Review Findings - Letter (PDF) (PDF - 72 KB)

AFCARS Assessment Review Report - Ohio (PDF) (PDF - 172 KB)

Tab A - Detailed Findings (PDF) (PDF - 7 KB)

Findings Instructions (PDF) (PDF - 52 KB)

Section I - General Requirements (PDF) (PDF - 8 KB)

AFCARS Assessment Review Findings - General Requirement (PDF) (PDF - 232 KB)

Section II - Foster Care and Adoption Elements / Diagnosed Conditions Table (PDF) (PDF - 8 KB)

AFCARS Assessment Review Findings - Foster Care and Adoption Data Elements (PDF) (PDF - 491 KB)

Section III - Case File Review (PDF) (PDF - 7 KB)

AFCARS Case File Summary Report - Ohio (PDF) (PDF - 81 KB)

AFCARS Assessment Review Case File Findings - Foster Care and Adoption Data Elements (PDF) (PDF - 428 KB)

Tab B - AFCARS Improvement Plan (PDF) (PDF - 7 KB)

Improvement Plan Instructions (PDF) (PDF - 82 KB)

Section I - General Requirements (PDF) (PDF - 8 KB)

AFCARS Assessment Review Improvement Plan - General Requirements (PDF) (PDF - 194 KB)

Section II - Foster Care and Adoption Elements (PDF) (PDF - 8 KB)

AFCARS Assessment Review Improvement Plan - Foster Care and Adoption Data Elements (PDF) (PDF - 587 KB)

AFCARS Close-out Letter (PDF) (PDF - 80 KB)

Metadata-only record linking to the original dataset. Open original dataset below.
Behavioral Health Barometer: Region 10, Volume 7

Explore state and regional data for HHS Region 10 with this user-friendly behavioral health report. It uses data from the 2021-2022 National Surveys on Drug Use and Health (NSDUH). The topics addressed in this report include substance use, substance use disorders, and mental health. Selected estimates are provided for adolescents aged 12 to 17, underage people aged 12 to 20, adults aged 18 or older, and the general population aged 12 or older. Statistical tests compare population percentages of (1) HHS region versus national estimates, (2) state versus national estimates, and (3) state versus HHS region estimates.
Weekly Cumulative RSV Vaccination Coverage and Intent, Overall, by Selected Demographics and Jurisdiction, Among Adults 75 and Older and 60-74 Years with High-Risk Conditions Ever Vaccinated, United States

• Weekly Cumulative RSV Vaccination Coverage and Intent Among Adults 75 Years and Older and 60─74 Years with High Risk Conditions Ever Vaccinated with RSV Vaccine by Demographic Characteristics and Jurisdiction 

• Weekly estimates of RSV vaccination coverage and intent among adults 75 years and older and 60─74 years with high risk conditions are calculated using data from the National Immunization Survey–Adult COVID Module (NIS–ACM) (https://www.cdc.gov/nis/about/index.html). 

• In June 2023, the Advisory Committee on Immunization Practices (ACIP) voted to recommend that adults aged ≥60 years may receive a single dose of an RSV vaccine, using shared clinical decision-making. In June 2024, the ACIP voted to recommend a single dose of RSV vaccine for all adults 75 years and older and adults 60–74 years who are at increased risk for severe RSV disease. The data below captures ever receiving a dose of an RSV vaccine by adults 60 years and older.
Growth factors in lung development and disease: friends or foe?

Growth factors mediate tissue interactions and regulate a variety of cellular functions that are critical for normal lung development and homeostasis. Besides their involvement in lung pattern formation, growth and cell differentiation during organogenesis, these factors have been also implicated in modulating injury-repair responses of the adult lung. Altered expression of growth factors, such as transforming growth factor β1, vascular endothelial growth factor and epidermal growth factor, and/or their receptors, has been found in a number of pathological lung conditions. In this paper, we discuss the dual role of these molecules in mediating beneficial feedback responses or responses that can further damage lung integrity; we shall also discuss the basis for their prospective use as therapeutic agents.
Patent AT-E401006-T1: [Translated] FAST HEAT RESISTANCE BUILD-UP IN CHOCOLATES OR CHOCOLATE-LIKE CONFECTIONAL PRODUCTS

Chemical patent from PubChem database. Patent Number: AT-E401006-T1. Title: Bioactive Compound and Applications. Filing Date: 2001-12-22. Inventors: Anderson, Robert, Davis, Linda. Abstract: A bioactive compound and its applications in pharmaceutical and agricultural fields are described. The compound exhibits significant biological activi... IPC Classifications: C07D, C07F, A61K. This patent covers 37 claims related to 8 chemical compounds. Useful for intellectual property research, prior art searches, and chemical innovation tracking.
Child Care and Development Fund Expenditure Data

The Child Care and Development Fund Expenditure data is compiled through data reported by States and Territories on the ACF-696 Financial Report.

<b>Units of Response: </b>States

<b>Type of Data: </b>Financial

<b>Tribal Data: </b>No

<b>Periodicity: </b>Annual

<b>Demographic Indicators: </b>Unavailable

<b>SORN: </b>Not Applicable

<b>Data Use Agreement: </b>Not Applicable

<b>Data Use Agreement Location: </b>Not Applicable

<b>Granularity: </b>State

<b>Spatial: </b>United States

<b>Geocoding: </b>State
Patent AT-E401033-T1: [Translated] COMMERCIAL DISHWASHER WITH IMPROVED HYDRAULIC CIRCUIT

An industrial dishwasher includes a first lower rack (1), upper and lower wash sprinklers (2, 3) fed by a wash pump (4) through respective wash ducts, upper and lower rinse sprinklers (9, 10) fed through respective rinse ducts with hot water coming from a heater (8), two valves (13, 14) located in the wash tank and respectively connected to the upper ducts of the wash and rinse circuits, as well as a second upper rack (1') provided underneath with a relevant support system that carries an additional wash sprinkler (15) and an additional rinse sprinkler (16) provided with respective ducts (17, 18) suitable for connection of the additional sprinklers (15, 16) to said valves (13, 14) when the second upper rack (1') is introduced in the wash tank. In this way, it is possible to carry out the wash of cups and glasses in absolute safety, since the addition of a third sprinkler implies a decrease of the flow rate and pressure of the sprinklers by approximately 30%, and there is obtained a greater efficiency and flexibility of use of the dishwasher since in a single wash cycle it is possible to double the load of cups and glasses with respect to a conventional industrial dishwasher.
South Dakota 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.
Elk Creek Seismic Waveforms 2011 (Part 15 of 19)

Coal bursts (damaging seismic events in underground coal mines) pose a substantial threat to operations and mine workers. The underground coal mines in Colorado’s North Fork Valley (NFV) have experienced many coal bursts, often with distinct characteristics from those of other US coal mining regions. To better understand these events and manage their associated risks, the National Institute for Occupational Safety and Health undertook a long-term monitoring campaign at the Elk Creek Mine in the NFV. The monitoring efforts included a seismic network composed of both surface and underground sensors, borehole pressure cells (BPCs), instrumented support Cans, convergence monitors, ground condition surveys, and several other data sources. This dataset consists of the event waveform files from the seismic network for the 983,379 events that were detected during the monitoring campaign. The waveforms are stored in HDF5 files that are broken up by week. Within the HDF5 files, the data are organized by station id, event time, and channel. The amplitudes are velocity in meters/second.
 
This is download 23 of 48 and corresponds to the time range between September 5, 2011, and September 26, 2011.
Medicare Quarterly Part D Spending by Drug

The Medicare Quarterly Part D Spending by Drug dataset presents information on spending for drugs prescribed to Medicare beneficiaries enrolled in Part D by physicians and other healthcare providers. Drugs prescribed in the Medicare Part D program are drugs patients generally administer themselves. It also includes spending information for manufacturer(s) of the drugs as well as consumer-friendly information of drug uses and clinical indications.

 

Drug spending metrics for Part D drugs are based on the gross drug cost, which represents total spending for the prescription claim, including Medicare, plan, and beneficiary payments. The Part D spending metrics do not reflect any manufacturers’ rebates or other price concessions as CMS is prohibited from publicly disclosing such information.

 

This dataset reports preliminary data that goes beyond the latest date available in the annual Medicare Part D Spending by Drug dataset. The data are updated each quarter and may change with each new release due to claims lag. Once an entire year of data is available with a sufficient run-out period, that data will move out of the preliminary quarterly dataset and into the annual Medicare Part D Spending by Drug dataset. Due to the preliminary nature of the quarterly dataset, we advise using caution when comparing between the annual and quarterly datasets.
Compound 528097: tert-Butyldimethylsilyl formate

Chemical compound data from PubChem database. IUPAC Name: [tert-butyl(dimethyl)silyl] formate. Molecular Formula: C7H16O2Si. Molecular Weight: 160.29. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Tribal Child Welfare Systems’ Experiences With Prenatal Exposure to Alcohol and Other Drugs: A Case Study

This report presents the findings of a federally funded case study that examined prenatal alcohol and other exposures in child welfare, including in Tribal child welfare systems. For the study, multiple listening sessions were held with diverse Tribal stakeholders across Minnesota in 2018 to understand issues related to prenatal substance exposure (PSE), to develop relationships with Tribes, and to inform the study. In 2019, the research team engaged the Ombimindwaa Gidinawemaaganinaadog Red Lake Family and Children Services agency to co-develop a case study. After Tribal council and IRB approval, in 2020 the Tribal liaison and a team member conducted two data collection efforts: a service process mapping activity, and interviews with nine key informants. Findings from the case study are reported and indicate: currently, no validated assessment or decision-making tools are used by this agency to guide the intake process when there are reports of prenatal alcohol or other drug exposures; participants were less aware of the relevant referral partners and the process to identify children affected by PSE than those processes for serving and supporting pregnant mothers; the two most frequent points of referral for pregnant mothers who are using substances are family preservation services and chemical dependency services for supporting pregnant mothers; challenges included struggles with maintaining and communicating processes consistently across agencies, and because all births currently occur off-reservation, the Tribal programs must follow the lead of external agencies. Themes that emerged from the interviews are also discussed and address the needs and strengths of the Tribal community, services for pregnant mothers and infants with PSE, facilitators to implementing services, challenges to implementing services, and recommendations for improved services. Finally, implications of the findings for Tribal child welfare program and federal agencies are explored.

Metadata-only record linking to the original dataset. Open original dataset below.
Compound 529237: Propanamide, O,N-bis-DMTBS

Chemical compound data from PubChem database. IUPAC Name: [tert-butyl(dimethyl)silyl] N-[tert-butyl(dimethyl)silyl]propanimidate. Molecular Formula: C15H35NOSi2. Molecular Weight: 301.61. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Understanding and Complying With Title VI of the Civil Rights Act of 1964 and The Multiethnic Placement Act of 1994, as amended by The Interethnic Adoption Provisions (IEP) - Video

Understanding and Complying With Title VI of the Civil Rights Act of 1964 and The Multiethnic Placement Act of 1994, as amended by The Interethnic Adoption Provisions (IEP)
  
  

 - This video provides an overview of how to understand and comply with title VI of the Civil Rights Act of 1964 and the Multiethnic Placement Act of 1994, as amended by the Interethnic Adoption Provisions.

Metadata-only record linking to the original dataset. Open original dataset below.
Compound 525168: Hexapropylene glycol, diacetate

Chemical compound data from PubChem database. IUPAC Name: 2-[2-[2-[2-[2-(2-acetyloxypropoxy)propoxy]propoxy]propoxy]propoxy]propyl acetate. Molecular Formula: C22H42O9. Molecular Weight: 450.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528001: Pentan-2-yl 3,5-dinitrobenzoate

Chemical compound data from PubChem database. IUPAC Name: pentan-2-yl 3,5-dinitrobenzoate. Molecular Formula: C12H14N2O6. Molecular Weight: 282.25. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.