AndreaBozzo/ceres-open-data-index huggingface dataset:
Patent AT-E400413-T1: [Translated] CUTTING MAT

A rotary anvil cutting mat comprising: na generally elongate body defining an axial length and a circumferential length, nsaid body having: nopposing first and second circumferential edges; and nopposing first a second axial edges, each arranged to have a nonlinear configuration when measured across the entirety of said axial length; na first end portion proximate said first axial edge having a first locking member, said first locking member arranged to be received between a first sidewall and a locking wedge of a channel lockup device; na second end portion proximate said second axial edge having a second locking member, wherein said cutting mat is wrappable into a generally cylindrical shape such that said first and second locking members abut in mating nrelationship, said second locking member further abuts said locking wedge opposite said first locking member, and said first and second axial edges define a seam therebetween.
Table 9. 2011-2012 NSDUH Alcohol Use in the Past Month, by Age Group and State

Table 9. Alcohol Use in the Past Month, by Age Group and State: Percentages, Annual Averages Based on 2011 and 2012 NSDUHs. Results are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.
Hospital Emergency Department Discharges (SPARCS De-Identified): Potentially Preventable Emergency Visit (PPV) Rates by Patient County: Beginning 2011

The datasets contain Potentially Preventable Visit (PPV) observed, expected, and risk-adjusted rates for all payer beneficiaries by patient county and patient zip code beginning in 2011.

The Potentially Preventable Visits (PPV), obtained from software created by 3M Health Information Systems, are emergency visits that may result from a lack of adequate access to care or ambulatory care coordination.  These ambulatory sensitive conditions could be reduced or eliminated with adequate patient monitoring and follow up.  

The rates were calculated using Statewide Planning and Research Cooperative System (SPARCS) inpatient and outpatient data and Claritas population information.  

The observed, expected and risk adjusted rates for PPV are presented by either resident county (including a statewide total) or resident zip code (including a statewide total).
A basis for a visual language for describing, archiving and analyzing functional models of complex biological systems

Background:
          We propose that a computerized, internet-based graphical description language for systems biology will be essential for describing, archiving and analyzing complex problems of biological function in health and disease.
        
        
          Results:
          We outline here a conceptual basis for designing such a language and describe BioD, a prototype language that we have used to explore the utility and feasibility of this approach to functional biology. Using example models, we demonstrate that a rather limited lexicon of icons and arrows suffices to describe complex cell-biological systems as discrete models that can be posted and linked on the internet.
        
        
          Conclusions:
          Given available computer and internet technology, BioD may be implemented as an extensible, multidisciplinary language that can be used to archive functional systems knowledge and be extended to support both qualitative and quantitative functional analysis.
Helicobacter pylori (H pylori) infection in Greece: the changing prevalence during a ten-year period and its antigenic profile

Background
          To evaluate changes in H pylori infection prevalence in Greece during a ten-year period, and to examine its antigenic profile.
        
        
          Methods
          Three groups of patients were studied. Group O-87: Banked serum samples of 200 consecutive adult outpatients, from the Hepato-Gastroenterology clinic of a teaching hospital at Athens, collected in 1987. Group O-97: Serum samples of 201 similarly selected outpatients from the same Unit, collected in 1997. Group BD-97: Serum samples of 120 consecutive blood donors from the same hospital, collected in 1997. H pylori IgG antibody seroprevalence was studied by a quantitative ELISA. Antigenic profile was studied by western-blot IgG assay, in 62 IgG positive patients of O-97 and BD-97. Results were analyzed by conventional statistics and multivariate regression analysis.
        
        
          Results
          The H pylori seroprevalence increased with age in the three tested groups. In O-97, seroprevalence did not differ from that, in BD-97. On the contrary, there was a significant decrease in seropositivity between O-87 and O-97 (59.5% vs 49.2%, p = 0.039). Multiple regression analysis showed that age over 35 years (OR:3.45, 95% CI:1.59–7.49, p = 0.002) and year of patients' selection – that is 1987 or 1997 – (OR:1.73, 95% CI:1.14–2.65 for 1987, p = 0.010), were independent risk factors of H pylori infection. The seroprevalence of CagA+ and VacA+ strains was 77.4% and 58.5%, respectively, and type I(CagA+/VacA+) strains were significantly more common than type II(CagA-/VacA-) strains (59.7% vs 22.6%, p < 0.001).
        
        
          Conclusions
          During a ten-year period, we found a significant decrease of H pylori infection in Greece and our data support the birth cohort phenomenon as an explanation for the age-dependent increase of H pylori infection. The prevalence of CagA and/or VacA positive strains is relatively high, in a country with low incidence of gastric cancer.
Compound 529232: tert-Butyl(dimethyl)silyl 2-([tert-butyl(dimethyl)silyl]amino)pentanoate

Chemical compound data from PubChem database. IUPAC Name: [tert-butyl(dimethyl)silyl] 2-[[tert-butyl(dimethyl)silyl]amino]pentanoate. Molecular Formula: C17H39NO2Si2. Molecular Weight: 345.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Molecular profile of synovial fibroblasts in rheumatoid arthritis depends on the stage of proliferation

The aim of this study was to explore the molecular profile of proliferating rheumatoid arthritis synovial fibroblasts (RA-SF). Total RNA was extracted from two cultures of RA-SF (low-density [LD] proliferating cells and high-density [HD] nonproliferating cells) and suppression subtractive hybridization was performed to compare differential gene expression of these two cultures. Subtracted cDNA was subcloned, and nucleotide sequences were analyzed to identify each clone. Differential expression of distinct clones was confirmed by semiquantitative RT-PCR. The expression of certain genes in synovial tissues was examined by in situ hybridization. In both LD and HD cells, 44 clones were upregulated. Of the 88 total clones, 46 were identical to sequences that have previously been characterized. Twenty-nine clones were identical to cDNAs that have been identified, but with unknown functions so far, and 13 clones did not show any significant homology to sequences in GenBank (NCBI). Differential expression of distinct clones was confirmed by RT-PCR. In situ hybridization showed that certain genes, such as S100A4, NFAT5, unr and Fbx3, were also expressed predominantly in synovial tissues from patients with RA but not from normal individuals. The expression of distinct genes in proliferating RA-SF could also be found in RA synovium, suggesting that these molecules are involved in synovial activation in RA. Most importantly, the data indicate that the expression of certain genes in RA-SF depends on the stage of proliferation; therefore, the stage needs to be considered in any analysis of differential gene expression in SF.
The BHSIS Report: Multi-year Analyses of TEDS and N-SSATS

This is a Treatment Episode Data Set (TEDS) and National Survey of Substance Abuse Treatment Services (N-SSATS) short report about the online analytic tools users can access to explore data on US substance abuse admissions and facilities. This spotlight is a multi-year analysis that covers 1992-2010 TEDS and 1997-2010 N-SSATS.
Compound 528649: Hexanedioic acid, 3-trimethylsiloxy-, bis(trimethylsilyl) ester

Chemical compound data from PubChem database. IUPAC Name: bis(trimethylsilyl) 3-trimethylsilyloxyhexanedioate. Molecular Formula: C15H34O5Si3. Molecular Weight: 378.68. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Carbamazepine reduces memory induced activation of mesial temporal lobe structures: a pharmacological fMRI-study

Background and Purpose
          It is not known whether carbamazepine (CBZ; a drug widely used in neurology and psychiatry) influences the blood oxygenation level dependent (BOLD) contrast changes induced by neuronal activation and measured by functional MRI (fMRI). We aimed to investigate the influence of CBZ on memory induced activation of the mesial temporal lobes in patients with symptomatic temporal lobe epilepsy (TLE).
        
        
          Material and Methods
          Twenty-one individual patients with refractory symptomatic TLE with different CBZ serum levels and 20 healthy controls were studied using BOLD fMRI. Mesial temporal lobe (MTL) activation was induced by a task that is based on the retrieval of individually familiar visuo-spatial knowledge. The extent of significant MTL fMRI activation was measured and correlated with the CBZ serum level.
        
        
          Results
          In TLE patients, the extent of significant fMRI activation over both MTL was negatively correlated to the CBZ serum level (Spearman r = -0.654, P < 0.001). Activation over the supposedly normal MTL, i.e. contralateral to the seizure onset of TLE patients, was smaller than the averaged MTL activation in healthy controls (P < 0.005). Age, duration of epilepsy, side of seizure onset, and intelligence were not correlated to the extent of the significant BOLD-response over both MTL in patients with TLE.
        
        
          Conclusions
          In TLE patients, carbamazepine reduces the fMRI-detectable changes within the mesial temporal lobes as induced by effortful memory retrieval. FMRI appears to be suitable to study the effects of chronic drug treatment in patients with epilepsy.
Compound 526086: Dodecanoic acid, 4-methyl, trimethylsilyl ester

Chemical compound data from PubChem database. IUPAC Name: trimethylsilyl 4-methyldodecanoate. Molecular Formula: C16H34O2Si. Molecular Weight: 286.52. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Di-, tri- and tetra-5'-

Background
          The human FHIT gene is inactivated early in the development of many human cancers and loss of Fhit in mouse predisposes to cancer while reintroduction of FHIT suppresses tumor formation via induction of apoptosis. Fhit protein, a diadenosine polyphosphate hydrolase, does not require hydrolase activity to function in tumor suppression and may signal for apoptosis as an enzyme-substrate complex. Thus, high affinity nonhydrolyzable substrate analogs may either promote or antagonize Fhit function, depending on their features, in Fhit + cells. Previously synthesized analogs with phosphorothioadenosyl substitutions and "supercharged" branches do not bind better than natural substrates and thus have limited potential as cellular probes.
        
        
          Results
          Here we link adenosine 5'-O-phosphates and phosphorothioates to short-chain polyols to generate a series of substrate analogs. We obtain structure-activity data in the form of in vitro Fhit inhibition for four types of analog substitutions and describe two compounds, inhibitory constants for which are 65 and 75-fold lower than natural substrates.
        
        
          Conclusions
          The best Fhit inhibitors obtained to date separate two or more 5'-O-phosphoromonothioadenosyl moieties with as many bond lengths as in AppppA, maintain oxygen at the location of the α-β bridging oxygen, and replace carbon for the β phosphorus.
NCHS - Drug Poisoning Mortality by County: United States

This dataset describes drug poisoning deaths at the county level by selected demographic characteristics and includes age-adjusted death rates for drug poisoning from 1999 to 2015.

Deaths are classified using the International Classification of Diseases, Tenth Revision (ICD–10). Drug-poisoning deaths are defined as having ICD–10 underlying cause-of-death codes X40–X44 (unintentional), X60–X64 (suicide), X85 (homicide), or Y10–Y14 (undetermined intent).

Estimates are based on the National Vital Statistics System multiple cause-of-death mortality files (1). Age-adjusted death rates (deaths per 100,000 U.S. standard population for 2000) are calculated using the direct method. Populations used for computing death rates for 2011–2015 are postcensal estimates based on the 2010 U.S. census. Rates for census years are based on populations enumerated in the corresponding censuses. Rates for noncensus years before 2010 are revised using updated intercensal population estimates and may differ from rates previously published.

Estimate does not meet standards of reliability or precision. Death rates are flagged as “Unreliable” in the chart when the rate is calculated with a numerator of 20 or less.

Death rates for some states and years may be low due to a high number of unresolved pending cases or misclassification of ICD–10 codes for unintentional poisoning as R99, “Other ill-defined and unspecified causes of mortality” (2). For example, this issue is known to affect New Jersey in 2009 and West Virginia in 2005 and 2009 but also may affect other years and other states. Estimates should be interpreted with caution.

Smoothed county age-adjusted death rates (deaths per 100,000 population) were obtained according to methods described elsewhere (3–5). Briefly, two-stage hierarchical models were used to generate empirical Bayes estimates of county age-adjusted death rates due to drug poisoning for each year during 1999–2015. These annual county-level estimates “borrow strength” across counties to generate stable estimates of death rates where data are sparse due to small population size (3,5). Estimates are unavailable for Broomfield County, Colo., and Denali County, Alaska, before 2003 (6,7). Additionally, Bedford City, Virginia was added to Bedford County in 2015 and no longer appears in the mortality file in 2015. County boundaries are consistent with the vintage 2005-2007 bridged-race population file geographies (6).
Expression of c-

Background
          A study was undertaken to resolve preliminary conflicting results on the proliferation of leukemia cells observed with different c-myc antisense oligonucleotides.
        
        
          Results
          RNase H-active, chimeric methylphosphonodiester / phosphodiester antisense oligodeoxynucleotides targeting bases 1147–1166 of c-myc mRNA downregulated c-Myc protein and induced apoptosis and cell cycle arrest respectively in cultures of MOLT-4 and KYO1 human leukemia cells. In contrast, an RNase H-inactive, morpholino antisense oligonucleotide analogue 28-mer, simultaneously targeting the exon 2 splice acceptor site and initiation codon, reduced c-Myc protein to barely detectable levels but did not affect cell proliferation in these or other leukemia lines. The RNase H-active oligodeoxynucleotide 20-mers contained the phosphodiester linked motif CGTTG, which as an apoptosis inducing CpG oligodeoxynucleotide 5-mer of sequence type CGNNN (N = A, G, C, or T) had potent activity against MOLT-4 cells. The 5-mer mimicked the antiproliferative effects of the 20-mer in the absence of any antisense activity against c-myc mRNA, while the latter still reduced expression of c-myc in a subline of MOLT-4 cells that had been selected for resistance to CGTTA, but in this case the oligodeoxynucleotide failed to induce apoptosis or cell cycle arrest.
        
        
          Conclusions
          We conclude that the biological activity of the chimeric c-myc antisense 20-mers resulted from a non-antisense mechanism related to the CGTTG motif contained within the sequence, and not through downregulation of c-myc. Although the oncogene may have been implicated in the etiology of the original leukemias, expression of c-myc is apparently no longer required to sustain continuous cell proliferation in these culture lines.
Compound 529183: 1-Propanol, 3-amino, O,N,N-tris-TMS

Chemical compound data from PubChem database. IUPAC Name: N,N-bis(trimethylsilyl)-3-trimethylsilyloxypropan-1-amine. Molecular Formula: C12H33NOSi3. Molecular Weight: 291.65. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 526766: Ethyl methylphenyl glycidate 1

Chemical compound data from PubChem database. IUPAC Name: ethyl 3-benzyloxirane-2-carboxylate. Molecular Formula: C12H14O3. Molecular Weight: 206.24. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E399807-T1: [Translated] BIS-HYDROXYPHENYLMENTHANE POLYESTER AND POLYESTER/POLYCARBONATES AND METHOD FOR THE PRODUCTION THEREOF

Polyphthalate polyesters or polyester/polycarbonates are prepared from phthalates and 4,4'-[1-methyl-4-(1-methyl-ethyl)-1,3-cyclohexandlyl]-bisphenol.
Federal Fiscal Year 2025 Title IV-B, Subpart 2 Funding Available to Develop and Enhance or to Evaluate Kinship Navigator Programs

This Program Instruction (PI) provides guidance to state, territorial and tribal title IV-E agencies on the actions required to apply for title IV-B, subpart 2 funding to support the development, enhancement or evaluation of kinship navigator programs. These are federal fiscal year (FY) 2025 funds, provided in P.L. 119-4, the Full- Year Continuing Appropriations and Extensions Act, 2025.

For the best usability of Attachment B, please download the file and save it to your computer.

Metadata-only record linking to the original dataset. Open original dataset below.
Desvenlafaxine succinate

Desvenlafaxine Succinate is a generic prescription medication available as extended-release oral tablets in 25 mg, 50 mg, and 100 mg strengths. It belongs to the class of serotonin and norepinephrine reuptake inhibitors, often used to treat major depressive disorder. Manufactured by Alembic Pharmaceuticals Limited and marketed by Direct Rx, it is approved under ANDA204003. This information was generated using AI and is provided for informational and research purposes only.
Patent AT-E400767-T1: [Translated] PIPE CONNECTION

A pipe fitting comprising a housing ( 10:37:41 ) defining at ore rolled over end thereof an opening ( 36 ) through which it is intended a predetermined diameter pipe ( 28 ) is inserted, in use, with a clearance space between the pipe and the housing, The fitting has a grip-ring ( 19 ) for gripping the pipe ( 28 ) and a pipe support means ( 20:38 ) downstream of the grip-ring and ahead of sealing means ( 21 ). Downstream of the sealing means, are means ( 22:40 ) for limiting movement of the sealing means. The rolled over end of the housing effects engagement of the grip-ring with the housing and thus ensures electrical continuity between an inserted pipe and the housing. Also disclosed is a release tool ( 42 ) for use with the fitting.
4.23 Facilities using counseling as part of their substance abuse treatment program, by primary focus of facility: March 31, 2011.  Number

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing facilities using counseling as part of their substance abuse treatment program, by primary focus of facility in 2011. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.
Compound 526285: 1,3,8-Tribromo-6-chloro-dibenzo-p-dioxin

Chemical compound data from PubChem database. IUPAC Name: 1,3,8-tribromo-6-chlorodibenzo-p-dioxin. Molecular Formula: C12H4Br3ClO2. Molecular Weight: 455.32. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Mutational analysis of human profilin I reveals a second PI(4,5)-P

Background
          Profilin is a small cytoskeletal protein which interacts with actin, proline-rich proteins and phosphatidylinositol 4,5-bisphosphate (PI(4,5)-P2). Crystallography, NMR and mutagenesis of vertebrate profilins have revealed the amino acid residues that are responsible for the interactions with actin and poly(L-proline) peptides. Although Arg88 of human profilin I was shown to be involved in PI(4,5)-P2-binding, it was suggested that carboxy terminal basic residues may be involved as well.
        
        
          Results 
          Using site directed mutagenesis we have refined the PI(4,5)-P2 binding site of human profilin I. For each mutant we assessed the stability and studied the interactions with actin, a proline-rich peptide and PI(4,5)-P2 micelles. We identified at least two PI(4,5)-P2-binding regions in human profilin I. As expected, one region comprises Arg88 and overlaps with the actin binding site. The second region involves Arg136 in the carboxy terminal helix and neighbours the poly(L-proline) binding site. In addition, we show that adding a small protein tag to the carboxy terminus of profilin strongly reduces binding to poly(L-proline), suggesting local conformational changes of the carboxy terminal α-helix may have dramatic effects on ligand binding.
        
        
          Conclusions 
          The involvement of the two terminal α-helices of profilin in ligand binding imposes important structural constraints upon the functions of this region. Our data suggest a model in which the competitive interactions between PI(4,5)-P2 and actin and PI(4,5)-P2 and poly(L-proline) regulate profilin functions.
Compound 529088: N-[1H-1,2,3-Benzotriazol-1-yl(2-furyl)methyl]-2-pyridinamine

Chemical compound data from PubChem database. IUPAC Name: 8-methyl-6,7,8,9-tetrahydropyrido[2,1-b]quinazolin-11-one. Molecular Formula: C13H14N2O. Molecular Weight: 214.26. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.