AndreaBozzo/ceres-open-data-index huggingface dataset:
Association of MHC and rheumatoid arthritis: Association of RA with HLA-DR4 - the role of repertoire selection

Most patients with rheumatoid arthritis (RA) express HLA-DR4, HLA-DR1 or HLA-DR10. These alleles share a common amino acid motif in their third hypervariable regions: the shared epitope. In normals and patients with RA, HLA-DR genes exert a major influence on the CD4 αβ T-cell repertoire, as shown by studies of AV and BV gene usage and by BV BJ gene usage by peripheral blood CD4 αβ T-cells. However, the rheumatoid T-cell repertoire is not entirely under HLA-DR influence, as demonstrated by discrepancies in VB JB gene usage between identical twins discordant for RA and by contraction of the CD4 αβ T-cell repertoire in RA patients. Shared epitope positive HLA-DR alleles may shape the T-cell repertoire by presenting self peptides to CD4 T cells in the thymus. Peptides processed from HLA-DR molecules and encompassing the shared epitope may also be presented by HLA-DQ and select CD4 αβ T cells in the thymus. Thus, shared epitope-positive alleles impose a frame on the T-cell repertoire. This predisposing frame is further modified (by unknown factors) to obtain the contracted rheumatoid repertoire.
Patent AT-E400735-T1: [Translated] INJECTION VALVE WITH OPTIMIZED SURFACE GEOMETRY BETWEEN A NOZZLE BODY AND A CLAMPING NUT

The injection valve has a housing, a nozzle body and a clamping nut connected to the housing that contacts the nozzle body with first contact surface ( 9 ) acting on a second contact surface ( 10 ), whereby the clamping nut clamps the nozzle body against the housing. The first or second contact surface has a curvature ( 24 ) towards the second or first contact surface and the both contact surfaces are in contact in the area of the curvature.
Compound 528360: 4-Ethyldihydro-2,6-dimethyl-4H-1,3,5-dithiazine

Chemical compound data from PubChem database. IUPAC Name: 4-ethyl-2,6-dimethyl-1,3,5-dithiazinane. Molecular Formula: C7H15NS2. Molecular Weight: 177.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Manipulation of prenatal hormones and dietary phytoestrogens during adulthood alter the sexually dimorphic expression of visual spatial memory

Background
          In learning and memory tasks, requiring visual spatial memory (VSM), males exhibit higher performance levels compared to females (a difference attributed to sex steroid hormonal influences). Based upon the results from our companion investigation, this study examined the influence of prenatal sex steroid hormone manipulations on VSM in adulthood, as assessed in the radial arm maze. Additionally, the influence of dietary soy phytoestrogens (i.e., the presence of high or low estrogen-like compounds present in the animal's diet) on VSM was examined in combination with the prenatal hormonal manipulations.
        
        
          Results
          Radial arm maze performance on a phytoestrogen-rich diet: 1) females treated prenatally with testosterone were masculinized and acquired/performed in a manner similar to control or oil-treated males and 2) males treated prenatally with an androgen receptor blocker (flutamide) were feminized and acquired/performed in a fashion typical of control or flutamide-treated females. When a diet change was initiated in adulthood, control phytoestrogen-rich fed females outperformed control females switched to a phytoestrogen-free diet. Whereas, in control males the opposite diet effect was identified. Furthermore, flutamide-treated males fed a phytoestrogen-rich diet outperformed flutamide-treated males switched to a phytoestrogen-free diet.
        
        
          Conclusions
          These results suggest that prenatal hormonal manipulations significantly sex-reverse the normal sexually dimorphic expression of VSM. Specifically, VSM was enhanced in females treated with testosterone and inhibited in males treated with flutamide. Finally, dietary soy phytoestrogens set a bias on learning and memory in these hormonally manipulated animals in a predictable manner and these data confirm and extend the findings in our companion paper (see Lund etal, BMC Neuroscience 2001 2:20).
Dynamic diversity of the tryptophan pathway in chlamydiae: reductive evolution and a novel operon for tryptophan recapture

The factors that accommodate the transition of different chlamydial species to the persistent state of pathogenesis include marked differences in the strategied deplyed to obtain tryptophan from host resources. Chlamydia psittaci appears to have a novel mechanism for intercepting an early intermediate of tryptophan catabolism and recycling it back to tryptophan.
Research Article: BMC Medical Genetics

Background
          SFHR (small fragment homologous replacement)-mediated targeting is a process that has been used to correct specific mutations in mammalian cells. This process involves both chemical and cellular factors that are not yet defined. To evaluate potential of this technique for gene therapy it is necessary to characterize gene transfer efficacy in terms of the transfection vehicle, the genetic target, and the cellular processing of the DNA and DNA-vehicle complex.
        
        
          Methods
          In this study, small fragments of genomic cystic fibrosis (CF) transmembrane conductance regulator (CFTR) DNA, that comprise the wild-type and ΔF508 sequences, were transfected into immortalized CF and normal airway epithelial cells, respectively. Homologous replacement was evaluated using PCR and sequence-based analyses of cellular DNA and RNA. Individual stages of cationic lipid-facilitated SFHR in cultured cell lines were also examined using transmission electron microscopy (TEM).
        
        
          Results
          We demonstrated that the lipid/DNA (+/-) ratio influences the mode of entry into the cell and therefore affects the efficacy of SFHR-mediated gene targeting. Lipid/DNA complexes with more negative ratios entered the cell via a plasma membrane fusion pathway. Transfer of the DNA that relies on an endocytic pathway appeared more effective at mediating SFHR. In addition, it was also clear that there is a correlation between the specific cell line transfected and the optimal lipid/DNA ratio.
        
        
          Conclusions
          These studies provide new insights into factors that underlie SFHR-mediated gene targeting efficacy and into the parameters that can be modulated for its optimization.
Compound 528289: Benzene, 1,2,3-trimethyl-5-(1-methylethyl)

Chemical compound data from PubChem database. IUPAC Name: 1,2,3-trimethyl-5-propan-2-ylbenzene. Molecular Formula: C12H18. Molecular Weight: 162.27. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 529501: Hept-4-en-2-yl acetate

Chemical compound data from PubChem database. IUPAC Name: hept-4-en-2-yl acetate. Molecular Formula: C9H16O2. Molecular Weight: 156.22. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 525799: N-(4-Methoxyphenyl)-N'-(4-bromophenyl)formamidine

Chemical compound data from PubChem database. IUPAC Name: N'-(4-bromophenyl)-N-(4-methoxyphenyl)methanimidamide. Molecular Formula: C14H13BrN2O. Molecular Weight: 305.17. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
The NSDUH Report: Need for and Receipt of Substance Use Treatment among American Indians or Alaska Natives

This report uses 2003 to 2011 National Survey on Drug Use and Health (NSDUH) to assess past year need for and receipt of alcohol use treatment and illicit drug use treatment among American Indian or Alaska Natives aged 12 or older in comparison to persons of other racial and ethnic groups. Results are shown by age group, gender, federal poverty level and rural/urban status.
Compound 526806: 16-Hydroxy-heptadecanoic acid, methyl ester, tBDMS ether

Chemical compound data from PubChem database. IUPAC Name: methyl 16-[tert-butyl(dimethyl)silyl]oxyheptadecanoate. Molecular Formula: C24H50O3Si. Molecular Weight: 414.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E399571-T1: [Translated] APATITE COATED METALLIC MATERIAL, METHOD FOR THE PRODUCTION AND USE THEREOF

Production of apatite-coated metal material by an electrochemical process using a metal substrate electrode, a counterelectrode and an electrolyte comprising an aqueous solution containing calcium and phosphate ions, comprises performing several successive cathodic polarization cycles comprising polarization in one or more stages at the same or different high constant current densities followed by a rinsing and/or drying step. An Independent claim is also included for an apatite-coated metal material in which the coating comprises a dense layer of hydroxyapatite crystals and/or amorphous calcium phosphate spheres and has a surface area of less than 15 m<2>/g.
Compound 530434: 2-Acetyl-2,3,5,6-tetrahydro-1,4-thiazine

Chemical compound data from PubChem database. IUPAC Name: 1-thiomorpholin-3-ylethanone. Molecular Formula: C6H11NOS. Molecular Weight: 145.23. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Departmental Appeals Board Decisions

<p>Decisions issued by the Chair and Board Members of the Departmental Appeals Board concerning determinations in discretionary, project grant programs, including disallowances, terminations and denials of refunding, cost allocation plan disapprovals, and rate determinations; determinations in mandatory grant programs, including disallowances of state claims under titles I, IV-A (Temporary Assistance for Needy Families), IV-D (Child Support Enforcement), IV-E (Foster Care and Adoption Assistance), X, XIV, XVI, XIX (Medicaid), and XXI (State Children's Health Insurance Program) of the Social Security Act; and appellate review of decisions of DAB Civil Remedies Division ALJs, decisions of Food and Drug Administration ALJs regarding civil money penalties, and decisions of Department of the Interior ALJs in Indian Health Service contract/compact cases.n.</p>
β-defensin-1 regulates influenza virus infection in human bronchial epithelial cells through the STAT3 signaling pathway

Understanding the host response to influenza A virus (IAV) infection is vital for developing intervention strategies. The primary barriers for invading respiratory pathogens are the airway epithelial cells of the respiratory tract and antimicrobial peptides produced by these cells. The antimicrobial peptide, β-defensin-1, has antiviral activity against both enveloped and non-enveloped viruses. Significant downregulation of β-defensin1 gene (DEFB1) expression was observed when human bronchial epithelial cells (HBEpCs) were exposed to IAV. HBEpCs overexpressing DEFB1 caused a significant reduction in IAV, that was confirmed by IAV matrix gene analysis and confocal microscopy. DEFB1expression after transfection with hsa-miR-186-5p and hsa-miR-340-5p provided evidence that DEFB1 expression could be modulated by these two miRNAs and hsa-miR-186-5p had a higher binding efficiency with DEFB1. Overexpression of DEFB1 in IAV infected HBEpCs led to increased NF-kB expression.  In a Polymerase Chain Reaction (PCR) array analysis of 84 transcription factors, either overexpressing DEFB1 or siRNA silencing of DEFB1 expression significantly modulated the expression of STAT3.  In addition, Ingenuity Pathway Analysis (IPA) integrated with PCR array data showed that the JAK1/STAT3 pathway was significantly altered by cells overexpressing DEFB1, suggesting that this may be one of the pathways by which defensin regulates IAV replication in HBEpCs. In conclusion, the reduction in IAV copy number in DEFB1 overexpressing cells suggests that β-defensin-1 plays a key role in regulating IAV survival through STAT3 and is a potential target for antiviral drug development.
Compound 530394: N-(2-Methylpropyl)-2,6,8-decatrienamide

Chemical compound data from PubChem database. IUPAC Name: N-(2-methylpropyl)deca-2,6,8-trienamide. Molecular Formula: C14H23NO. Molecular Weight: 221.34. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 529189: 3-Aminoheptane, mono-TMS

Chemical compound data from PubChem database. IUPAC Name: N-trimethylsilylheptan-2-amine. Molecular Formula: C10H25NSi. Molecular Weight: 187.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Wyoming (WY)

This report uses 2008 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past year alcohol use disorder and illicit drug use disorder among persons aged 12 or older for Wyoming overall and for substate regions within Wyoming. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE).
Compound 529986: Heptanoic acid, 2-bromo, methyl ester

Chemical compound data from PubChem database. IUPAC Name: methyl 2-bromoheptanoate. Molecular Formula: C8H15BrO2. Molecular Weight: 223.11. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528732: Dopamine, DTFMB-TBDMS

Chemical compound data from PubChem database. IUPAC Name: N-[2-[3,4-bis[[tert-butyl(dimethyl)silyl]oxy]phenyl]ethyl]-3,5-bis(trifluoromethyl)benzamide. Molecular Formula: C29H41F6NO3Si2. Molecular Weight: 621.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 527112: Bicyclo[4.4.0]-1,4-decadiene, 4,10-dimethyl-7-isopropyl

Chemical compound data from PubChem database. IUPAC Name: 5,8a-dimethyl-3-propan-2-yl-2,3,4,6-tetrahydro-1H-naphthalene. Molecular Formula: C15H24. Molecular Weight: 204.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
NNDSS - TABLE 1F. Brucellosis to Candida auris, clinical

NNDSS - Table 1F. Brucellosis to Candida auris, clinical - 2019. In this Table, provisional cases* of notifiable diseases are displayed for United States, U.S. territories, and Non-U.S. residents. 

Note: 
This table contains provisional cases of national notifiable diseases from the National Notifiable Diseases Surveillance System (NNDSS). NNDSS data from the 50 states, New York City, the District of Columbia and the U.S. territories are collated and published weekly on the NNDSS Data and Statistics web page (https://wwwn.cdc.gov/nndss/data-and-statistics.html). Cases reported by state health departments to CDC for weekly publication are provisional because of the time needed to complete case follow-up. Therefore, numbers presented in later weeks may reflect changes made to these counts as additional information becomes available. The national surveillance case definitions used to define a case are available on the NNDSS web site at https://wwwn.cdc.gov/nndss/. Information about the weekly provisional data and guides to interpreting data are available at: https://wwwn.cdc.gov/nndss/infectious-tables.html. 

Footnotes:
U: Unavailable — The reporting jurisdiction was unable to send the data to CDC or CDC was unable to process the data.
-: No reported cases — The reporting jurisdiction did not submit any cases to CDC.
N: Not reportable — The disease or condition was not reportable by law, statute, or regulation in the reporting jurisdiction.
NN: Not nationally notifiable — This condition was not designated as being nationally notifiable.
NP: Nationally notifiable but not published — CDC does not have data because of changes in how conditions are categorized.
Cum: Cumulative year-to-date counts.
Max: Maximum — Maximum case count during the previous 52 weeks.
* Case counts for reporting years 2018 and 2019 are provisional and subject to change. Cases are assigned to the reporting jurisdiction submitting the case to NNDSS, if the case's country of usual residence is the US, a US territory, unknown, or null (i.e. country not reported); otherwise, the case is assigned to the 'Non-US Residents' category. For further information on interpretation of these data, see https://wwwn.cdc.gov/nndss/document/Users_guide_WONDER_tables_cleared_final.pdf. 
† Previous 52 week maximum and cumulative YTD are determined from periods of time when the condition was reportable in the jurisdiction (i.e., may be less than 52 weeks of data or incomplete YTD data). 
§ Candida auris, clinical colonization/screening cases are not included in this table. These data are available on the Mycotic Diseases Branch's Tracking Candida auris page (https://www.cdc.gov/fungal/candida-auris/tracking-c-auris.html).
Patent AT-E399711-T1: [Translated] DEVICE AND METHOD FOR PRODUCING AND FILLING FLEXIBLE BAGS

Disclosed are flexible pouches including a process for manufacturing said pouches from preforms. Also disclosed is a process for manufacturing and filling said pouches wherein the preform/pouch is handled via the neck portion throughout the production line. In one embodiment, the filled pouch is further dressed, decorated, or inserted into a rigid outer container, for example a box. In a preferred embodiment, the production line is a modified version of the type commonly used for handling rigid containers, such as those used to manufacture and fill soft drinks.
FY 2013 Children's Bureau Discretionary Grant Awards

This document provides a list of Children's Bureau discretionary grants awarded in fiscal year 2013:

Tribal Title IV-E Plan Development Grants HHS-2013-ACF-ACYF-CS-0579

Up to $300,000 for one 24 month project/budget period

Building Child Welfare Capacity for Continuous Improvement Project HHS-2013-ACF-ACYF-CO-0580

Up to $2,000,000 for one 17 month project/budget period

Adoption Recruitment Campaign and Response Initiative HHS-2013-ACF-ACYF-CO-0586

Up to $1,500,000 per budget period with up to one 6-month and four 12-month budget periods

Comprehensive Support Services for Families Affected by Substance Abuse and HIV/AIDS HHS-2013-ACF-ACYF-CB-0592

Up to $475,000 per year for up to three years

Diligent Recruitment of Families for Children in the Foster Care System HHS-2013-ACF-ACYF-CO-0593

Up to $400,000 per year for up to five years

Child Welfare Training: The National Center for Child Welfare Curriculum Development on Evidence-Based Treatment Services HHS-2013-ACF-ACYF-CT-0595

Up to $1,000,000 per year for up to five years

Child Welfare Training: The National Child Welfare Workforce Institute HHS-2013-ACF-ACYF-CT-0596

Up to $4,100,000 per year for up to five years

Planning Grants to Develop a Model Intervention for Youth/Young Adults with Child Welfare Involvement At-Risk of Homelessness HHS-2013-ACF-ACYF-CA-0636

Up to $360,000 per year for up to two years

Promoting Well-Being and Adoption after Trauma HHS-2013-ACF-ACYF-CO-0637

Up to $500,000 per year for up to five years

Metadata-only record linking to the original dataset. Open original dataset below.
Youth Risk Behavior Surveillance System (YRBSS)

<p>The Youth Risk Behavior Surveillance System (YRBSS) monitors 6 types of health-risk behaviors that contribute to the leading causes of death and disability among youth and adults, including: behaviors that contribute to unintentional injuries and violence; sexual behaviors that contribute to unintended pregnancy and sexually transmitted diseases (STDs), including HIV infection; alcohol and other drug use; tobacco use; unhealthy dietary behaviors; inadequate physical activity. YRBSS also measures the prevalence of obesity and asthma among youth and young adults. YRBSS includes a national school-based survey conducted by CDC and state, territorial, tribal, and local surveys conducted by state, territorial, and local education and health agencies and tribal governments.</p>
Compound 525148: 1-Propanol, 2-(2-(acetyloxy)propoxy)-, 1-acetate

Chemical compound data from PubChem database. IUPAC Name: 2-(2-acetyloxypropoxy)propyl acetate. Molecular Formula: C10H18O5. Molecular Weight: 218.25. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 530488: m-Anisic acid, 1-adamantylmethyl ester

Chemical compound data from PubChem database. IUPAC Name: 1-adamantylmethyl 3-methoxybenzoate. Molecular Formula: C19H24O3. Molecular Weight: 300.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Results from the 2012 National Survey on Drug Use and Health: Mental Health Findings

This report present results from the 2012 National Survey on Drug Use and Health (NSDUH) Mental Health Findings, including national estimates of the prevalence of past year mental disorders and past year mental health service utilization for youths aged 12 to 17 and adults aged 18 or older. Among adults, estimates presented include rates and numbers of persons with any mental illness (AMI), serious mental illness (SMI), suicidal thoughts and behavior, major depressive episode (MDE), treatment for depression (among adults with MDE), and mental health service utilization. Estimates for youths include MDE, treatment for depression (among youths with MDE), and mental health service utilization. Measures related to the co-occurrence of mental disorders with substance use or with substance use disorders also are presented for both adults and youths. The report focuses mainly on trends between 2011 and 2012.  Results are also provided by age group, gender, race/ethnicity, education level, employment status, county type, poverty level, insurance status, overal health, and geographic area.
HumanCCSgene: genomic organization and exclusion as a candidate for amyotrophic lateral sclerosis (ALS)

Amyotrophic lateral sclerosis (ALS) is a progressive lethal disorder of large motor neurons of the spinal cord and brain. In approximately 20% of the familial and 2% of sporadic cases the disease is due to a defect in the gene encoding the cytosolic antioxidant enzyme Cu, Zn-superoxide dismutase (SOD1). The underlying molecular defect is known only in a very small portion of the remaining cases and therefore involvement of other genes is likely. As SOD1 receives copper, essential for its normal function, by the copper chaperone, CCS (Copper Chaperone for SOD), we consideredCCSas a potential candidate gene for ALS.