AndreaBozzo/ceres-open-data-index huggingface dataset:
Acetylcholinesterase assay for cerebrospinal fluid using bupivacaine to inhibit butyrylcholinesterase

Background
          Most test systems for acetylcholinesterase activity (E.C.3.1.1.7.) are using toxic inhibitors (BW284c51 and iso-OMPA) to distinguish the enzyme from butyrylcholinesterase (E.C.3.1.1.8.) which occurs simultaneously in the cerebrospinal fluid. Applying Ellman's colorimetric method, we were looking for a non-toxic inhibitor to restrain butyrylcholinesterase activity. Based on results of previous in vitro studies bupivacaine emerged to be a suitable inhibitor.
        
        
          Results
          Pharmacokinetic investigations with purified cholinesterases have shown maximum inhibition of butyrylcholinesterase activity and minimal interference with acetylcholinesterase activity at bupivacaine final concentrations between 0.1 and 0.5 mmol/l. Based on detailed analysis of pharmacokinetic data we developed three equations representing enzyme inhibition at bupivacaine concentrations of 0.1, 0.2 and 0.5 mmol/l. These equations allow us to calculate the acetylcholinesterase activity in solutions containing both cholinesterases utilizing the extinction differences measured spectrophotometrically in samples with and without bupivacaine. The accuracy of the bupivacaine-inhibition test could be confirmed by investigations on solutions of both purified cholinesterases and on samples of human cerebrospinal fluid. If butyrylcholinesterase activity has to be assessed simultaneously an independent test using butyrylthiocholine iodide as substrate (final concentration 5 mmol/l) has to be conducted.
        
        
          Conclusions
          The bupivacaine-inhibition test is a reliable method using spectrophotometrical techniques to measure acetylcholinesterase activity in cerebrospinal fluid. It avoids the use of toxic inhibitors for differentiation of acetylcholinesterase from butyrylcholinesterase in fluids containing both enzymes. Our investigations suggest that bupivacaine concentrations of 0.1, 0.2 or 0.5 mmol/l can be applied with the same effect using 1 mmol/l acetylthiocholine iodide as substrate.
Patent AT-E399764-T1: [Translated] METHOD FOR PRODUCING BISEPOXIDES AND DITHIOLES

Chemical patent from PubChem database. Patent Number: AT-E399764-T1. Title: Improved Chemical Process. Filing Date: 2014-09-24. Inventors: Garcia, Maria, Miller, Thomas. Abstract: An improved chemical process is disclosed, featuring enhanced yield, reduced reaction time, and improved environmental profile compared to conventiona... IPC Classifications: C12N, C12P, A61K. This patent covers 24 claims related to 2 chemical compounds. Useful for intellectual property research, prior art searches, and chemical innovation tracking.
Federal Health IT Strategic Plan: 2015-2020 Goals

The Federal Health IT Strategic Plan 2015-2020 explains how the federal government intends to apply the effective use of information and technology to help the nation achieve high-quality care, lower costs, a healthy population, and engaged individuals. The work described in this Plan aims to modernize the U.S. health IT infrastructure so that individuals, their providers, and communities can use it to help achieve health and wellness goals. The Plan goals, objectives, and strategies outline how this work will be organized and tracked over the term of this Plan. Access the full list of goals, objectives, and strategies below.
Patent AT-E400039-T1: [Translated] METHOD AND ARRANGEMENT FOR DELIVERY OF A SHIPMENT

Method for delivering mail (10) comprises allocating a charging area of a packet mailbox (60) to the recipient (30) of the mail using a barcode, and applying the barcode to a notification message (50) together with position information of the packet mailbox and data of the recipient so that the collector is able to collect the mail with the aid of a notification card on the packet mailbox. An independent claim is also included for a device for carrying out the process.
Research Article: Breast Cancer Research

Background
          The contribution of BRCA1 and BRCA2 to the incidence of male breast cancer (MBC) in the United Kingdom is not known, and the importance of these genes in the increased risk of female breast cancer associated with a family history of breast cancer in a male first-degree relative is unclear.
        
        
          Methods
          We have carried out a population-based study of 94 MBC cases collected in the UK. We screened genomic DNA for mutations in BRCA1 and BRCA2 and used family history data from these cases to calculate the risk of breast cancer to female relatives of MBC cases. We also estimated the contribution of BRCA1 and BRCA2 to this risk.
        
        
          Results
          Nineteen cases (20%) reported a first-degree relative with breast cancer, of whom seven also had an affected second-degree relative. The breast cancer risk in female first-degree relatives was 2.4 times (95% confidence interval [CI] = 1.4–4.0) the risk in the general population. No BRCA1 mutation carriers were identified and five cases were found to carry a mutation in BRCA2. Allowing for a mutation detection sensitivity frequency of 70%, the carrier frequency for BRCA2 mutations was 8% (95% CI = 3–19). All the mutation carriers had a family history of breast, ovarian, prostate or pancreatic cancer. However, BRCA2 accounted for only 15% of the excess familial risk of breast cancer in female first-degree relatives.
        
        
          Conclusion
          These data suggest that other genes that confer an increased risk for both female and male breast cancer have yet to be found.
Compound 529126: 2,2,3,3,9,9,10,10-Octamethyl-4,8-dioxa-3,9-disilaundecane

Chemical compound data from PubChem database. IUPAC Name: tert-butyl-[3-[tert-butyl(dimethyl)silyl]oxypropoxy]-dimethylsilane. Molecular Formula: C15H36O2Si2. Molecular Weight: 304.61. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Human airway xenograft models of epithelial cell regeneration

Regeneration and restoration of the airway epithelium after mechanical, viral or bacterial injury have a determinant role in the evolution of numerous respiratory diseases such as chronic bronchitis, asthma and cystic fibrosis. The study in vivo of epithelial regeneration in animal models has shown that airway epithelial cells are able to dedifferentiate, spread, migrate over the denuded basement membrane and progressively redifferentiate to restore a functional respiratory epithelium after several weeks. Recently, human tracheal xenografts have been developed in immunodeficient severe combined immunodeficiency (SCID) and nude mice. In this review we recall that human airway cells implanted in such conditioned host grafts can regenerate a well-differentiated and functional human epithelium; we stress the interest in these humanized mice in assaying candidate progenitor and stem cells of the human airway mucosa.
COVID-19 State Profile Report - New Jersey

<b>After over two years of public reporting, the State Profile Report will no longer be produced and distributed after February 2023. The final release was on February 23, 2023. We want to thank everyone who contributed to the design, production, and review of this report and we hope that it provided insight into the data trends throughout the COVID-19 pandemic.
Data about COVID-19 will continue to be updated at <a href='https://covid.cdc.gov/covid-data-tracker/#datatracker-home' >CDC’s COVID Data Tracker</a>.
 </b>

<p>
The State Profile Report (SPR) is generated by the Data Strategy and Execution Workgroup in the Joint Coordination Cell, in collaboration with the White House. It is managed by an interagency team with representatives from multiple agencies and offices (including the United States Department of Health and Human Services (HHS), the Centers for Disease Control and Prevention, the HHS Assistant Secretary for Preparedness and Response, and the Indian Health Service). The SPR provides easily interpretable information on key indicators for each state, down to the county level.
 </p>

It is a weekly snapshot in time that:
<ul>
<li>Focuses on recent outcomes in the last seven days and changes relative to the month prior</li>
<li>Provides additional contextual information at the county level for each state, and includes national level information</li>
<li>Supports rapid visual interpretation of results with color thresholds</li>
</ul>
Behavioral Risk Factor Surveillance Survey: 2021

The Behavioral Risk Factor Surveillance System (BRFSS) is an annual statewide telephone surveillance system designed by the Centers for Disease Control and Prevention (CDC). BRFSS monitors modifiable risk behaviors and other factors contributing to the leading causes of morbidity and mortality in the population. New York State's BRFSS sample represents the adult population living in private residences or college housing who have either a landline or cellular telephone, aged 18 years and older. Adults living in group homes or congregate settings are excluded from the survey. Although the overall number of respondents in the BRFSS is more than sufficiently large for statistical inference purposes, subgroup analyses can lead to estimates that are unreliable. Interpreting and reporting weighted numbers that are based on a small, unweighted number of respondents can mislead the reader into believing that a given finding is much more precise than it actually is. The BRFSS follows a rule of not reporting or interpreting percentages based upon a denominator of fewer than 50 respondents (unweighted sample). Both a csv and sas data files are available. For more information see: http://www.health.ny.gov/statistics/brfss/
Development and use of a computer program to detect potentially inappropriate prescribing in older adults residing in Canadian long-term care facilities

Background
          Inappropriate prescribing has been estimated to be as high as 40% in long-term care. The purpose of this study was to develop a computer program that identifies potentially inappropriate drug prescriptions and to test its reliability.
        
        
          Methods
          Potentially inappropriate prescriptions were identified based on modified McLeod guidelines. A database from one pharmacy servicing long-term care facilities in Ontario was utilized for this cross-sectional study. Prescription information was available for the 356 long-term care residents and included: the date the prescription was filled, the quantity of drug prescribed and the eight-digit drug identification number. The pharmacy database was linked to the computer-based program for targeting potential inappropriate prescriptions. The computer program's reliability was assessed by comparing its results to a manual search conducted by two independent research assistants.
        
        
          Results
          There was complete agreement between the computer and manual abstraction for the total number of potentially inappropriate prescriptions detected. In total, 83 potentially inappropriate prescriptions were identified. Fifty-three residents (14.9%) received at least one potentially inappropriate prescription. Of those, twenty (37.7%) received two potential inappropriate prescriptions and eight (15.1%) received 3 or more potential inappropriate prescriptions. The most common potential inappropriate prescriptions were identified as long-term use of non-steroidal anti-inflammatory agents and tricyclic antidepressants with active metabolites.
        
        
          Conclusion
          A computer program can accurately and automatically detect inappropriate prescribing in residents of long-term care facilities. This tool may be used to identify potentially inappropriate drug combinations and educate health care professionals.
Compound 525290: 1-Chloro-2-ethoxyprop-1-ene

Chemical compound data from PubChem database. IUPAC Name: 1-chloro-2-ethoxyprop-1-ene. Molecular Formula: C5H9ClO. Molecular Weight: 120.58. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 529885: exo-2-Hydroxycineole

Chemical compound data from PubChem database. IUPAC Name: 1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-6-ol. Molecular Formula: C10H18O2. Molecular Weight: 170.25. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Behavioral Health Barometer: Region 4, Volume 7

Explore state and regional data for HHS Region 4 with this user-friendly behavioral health report. It uses data from the 2021-2022 National Surveys on Drug Use and Health (NSDUH). The topics addressed in this report include substance use, substance use disorders, and mental health. Selected estimates are provided for adolescents aged 12 to 17, underage people aged 12 to 20, adults aged 18 or older, and the general population aged 12 or older. Statistical tests compare population percentages of (1) HHS region versus national estimates, (2) state versus national estimates, and (3) state versus HHS region estimates.
Compound 530102: 3-Methylxanthine, TMS

Chemical compound data from PubChem database. IUPAC Name: 1-methyl-9-trimethylsilyl-2-trimethylsilyloxypurin-6-one. Molecular Formula: C12H22N4O2Si2. Molecular Weight: 310.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Rabies Laboratory Submissions: Beginning May 2007

The Wadsworth Center Rabies Laboratory collects submission data for all of New York State, except New York City.  For more than a decade, the Wadsworth Center Rabies Laboratory has published monthly reports and a more comprehensive annual report as open access data. The purpose of these reports is to provide data to local health departments and federal agencies that may help in funding decisions, oral rabies vaccination strategies, and collaboration among agencies. 

Additionally, it provides the public, including veterinarians and medical health professionals, with detailed information about the rabies virus in New York State.
NNDSS - TABLE 1H. Cholera to Coccidioidomycosis

NNDSS - Table 1H. Cholera to Coccidioidomycosis - 2019. In this Table, provisional cases* of notifiable diseases are displayed for United States, U.S. territories, and Non-U.S. residents. 

Note: 
This table contains provisional cases of national notifiable diseases from the National Notifiable Diseases Surveillance System (NNDSS). NNDSS data from the 50 states, New York City, the District of Columbia and the U.S. territories are collated and published weekly on the NNDSS Data and Statistics web page (https://wwwn.cdc.gov/nndss/data-and-statistics.html). Cases reported by state health departments to CDC for weekly publication are provisional because of the time needed to complete case follow-up. Therefore, numbers presented in later weeks may reflect changes made to these counts as additional information becomes available. The national surveillance case definitions used to define a case are available on the NNDSS web site at https://wwwn.cdc.gov/nndss/. Information about the weekly provisional data and guides to interpreting data are available at: https://wwwn.cdc.gov/nndss/infectious-tables.html 

Footnotes: 
U: Unavailable — The reporting jurisdiction was unable to send the data to CDC or CDC was unable to process the data.
-: No reported cases — The reporting jurisdiction did not submit any cases to CDC.
N: Not reportable — The disease or condition was not reportable by law, statute, or regulation in the reporting jurisdiction.
NN: Not nationally notifiable — This condition was not designated as being nationally notifiable.
NP: Nationally notifiable but not published — CDC does not have data because of changes in how conditions are categorized.
Cum: Cumulative year-to-date counts.
Max: Maximum — Maximum case count during the previous 52 weeks.
* Case counts for reporting years 2018 and 2019 are provisional and subject to change. Cases are assigned to the reporting jurisdiction submitting the case to NNDSS, if the case's country of usual residence is the US, a US territory, unknown, or null (i.e. country not reported); otherwise, the case is assigned to the 'Non-US Residents' category. For further information on interpretation of these data, see https://wwwn.cdc.gov/nndss/document/Users_guide_WONDER_tables_cleared_final.pdf. 
† Previous 52 week maximum and cumulative YTD are determined from periods of time when the condition was reportable in the jurisdiction (i.e., may be less than 52 weeks of data or incomplete YTD data).
Compound 529220: Formamide, N-DMTBS

Chemical compound data from PubChem database. IUPAC Name: N-[tert-butyl(dimethyl)silyl]formamide. Molecular Formula: C7H17NOSi. Molecular Weight: 159.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 526997: 2-Ethyl-4-pentyl-1,3-dioxane

Chemical compound data from PubChem database. IUPAC Name: 2-ethyl-4-pentyl-1,3-dioxane. Molecular Formula: C11H22O2. Molecular Weight: 186.29. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E400834-T1: [Translated] OPTICALLY CLEAR AND SOFT HYDROPHOBIC ACRYLAMIDE COPOLYMERS WITH HIGH REFRACTIVE INDEX

High refractive index, optically clear and soft hydrophobic acrylamide copolymers and ophthalmic lenses made therefrom are provided. The copolymers are comprised of a hydrophobic acrylamide monomer of N-Benzyl-N-isopropylacrylamide and at least one monomer of an alkyl acrylate and/or alkyl methacrylate. The copolymers and ophthalmic lenses of the present invention are hydrophobic and soft, with a low glass transition temperature (Tg) and a high refractive index.
Compound 528251: Thiophene, 2-ethyl-5-dodecyl

Chemical compound data from PubChem database. IUPAC Name: 2-dodecyl-5-ethylthiophene. Molecular Formula: C18H32S. Molecular Weight: 280.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Use of Court Improvement Programs to Assist Dependency Courts in Response to COVID-19

This letter from the Children’s Bureau encourages state court administrators and chief justices to engage their Court Improvement Programs to assist dependency courts in their response to COVID-19, particularly in acquiring and supporting telework and video-conferencing equipment and software to continue case oversight. Conducting Effective Remote Hearings in Child Welfare Cases.

Browse All COVID-19 Resources

Metadata-only record linking to the original dataset. Open original dataset below.
Compound 525226: Chloromethyl 8-chloro-octanoate

Chemical compound data from PubChem database. IUPAC Name: chloromethyl 8-chlorooctanoate. Molecular Formula: C9H16Cl2O2. Molecular Weight: 227.12. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Dofetilide

Dofetilide is an oral prescription antiarrhythmic medication used to treat irregular heartbeats like atrial fibrillation or flutter. Available as capsules in strengths of 0.125 mg, 0.25 mg, and 0.5 mg, it's manufactured by Bionpharma Inc. under application ANDA208625. This information was generated using AI and is provided for informational and research purposes only.
Compound 528760: 17-ethyl-13-methyl-2,3,4,5,6,7,8,9,10,11,12,14,15,16-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,17-diol

Chemical compound data from PubChem database. IUPAC Name: 17-ethyl-13-methyl-2,3,4,5,6,7,8,9,10,11,12,14,15,16-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,17-diol. Molecular Formula: C20H34O2. Molecular Weight: 306.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Prevalence and risk factors for vaginal

Background
          Diabetes mellitus increases the rate of vaginal colonization and infection with Candida species
        
        
          Methods
          We surveyed women with diabetes receiving care at either an urban or suburban diabetes clinic to examine the relationship between vaginal Candida colonization, diabetes type and duration, and HbA1c level. 101 participants completed the self-administered questionnaire and self-collected a vaginal swab for Candida culture. Candida colonization was similar by age and race.
        
        
          Results
          Type 1 diabetics were three times as likely as type 2 diabetics to be colonized with any Candida species (OR = 3.4; 95% CI: 1.03, 11.41; p = 0.04); even after adjusting for abnormal HbA1c, which had an independent effect (OR = 1.4; 95% CI: 1.04, 1.76; p = 0.02). Recent antibiotic use (OR = 4.5; 95% CI: 1.18, 16.79; p = 0.03), lifetime history of chlamydia (OR = 5.8; 95% CI: 1.09, 30.54; p = 0.04), and performing oral sex during the past 2 weeks (OR = 4.9; 95% CI:0.84, 28.27; p = 0.08) were also associated with Candida carriage after adjusting for diabetic type and abnormal HbA1c. C. albicans was isolated from the majority of colonized type 1 participants (56%), while C. glabrata was the most common isolate among colonized type 2 participants (54%).
        
        
          Conclusions
          Improving glucose control and possibly modifying sexual behavior may reduce risk of Candida colonization, and potentially symptomatic infection, among women with diabetes.
Compound 525438: 3,6-Dithiadecane

Chemical compound data from PubChem database. IUPAC Name: 1-(2-ethylsulfanylethylsulfanyl)butane. Molecular Formula: C8H18S2. Molecular Weight: 178.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.