AndreaBozzo/ceres-open-data-index huggingface dataset:
Peptide binding characteristics of the non-classical class Ib MHC molecule HLA-E assessed by a recombinant random peptide approach

Background
          Increasing evidence suggests that the effect of HLA-E on Natural Killer (NK) cell activity can be affected by the nature of the peptides bound to this non-classical, MHC class Ib molecule. However, its reduced cell surface expression, and until recently, the lack of specific monoclonal antibodies hinder studying the peptide-binding specificity HLA-E.
        
        
          Results
          An in vitro refolding system was used to assess binding of recombinant HLA-E to either specific peptides or a nonamer random peptide library. Peptides eluted from HLA-E molecules refolded around the nonamer library were then used to determine a binding motif for HLA-E. Hydrophobic and non-charged amino acids were found to predominate along the peptide motif, with a leucine anchor at P9, but surprisingly there was no methionine preference at P2, as suggested by previous studies.
        
        
          Conclusions
          Compared to the results obtained with rat classical class Ia MHC molecules, RT1-A1c and RT1-Au, HLA-E appears to refold around a random peptide library to reduced but detectable levels, suggesting that this molecule's specificity is tight but probably not as exquisite as has been previously suggested. This, and a previous report that it can associate with synthetic peptides carrying a viral sequence, suggests that HLA-E, similar to its mouse counterpart (Qa-1b), could possibly bind peptides different from MHC class I leader peptides and present them to T lymphocytes.
Study of Womens Health Across the Nation (SWAN) Public Use Data

<p>The SWAN Public Use Datasets provide access to longitudinal data describing the physical, biological, psychological, and social changes that occur during the menopausal transition. Data collected from 3,302 SWAN participants from Baseline through the 10th Annual Follow-Up visit are currently available to the public.  Registered users are able to download datasets in a variety of formats, search variables and view recent publications.</p>
Patent AT-E399655-T1: [Translated] DEVICE AND METHOD FOR PAINTING AND RUST REMOVAL

A method and a device for the removal of rust and paint from a metal surface, wherein induction heat is used for heating the metal surface. The device includes an electrical power supply coupled to an induction coil. A wheel and a tachometer on the device measure the velocity of the device as the wheel rotates on the metal surface. A control unit regulates the power output of the electrical power supply based upon the measured velocity of the device.
Compound 525653: p-Bromobenzylidene-(3-bromophenyl)-amine

Chemical compound data from PubChem database. IUPAC Name: N-(3-bromophenyl)-1-(4-bromophenyl)methanimine. Molecular Formula: C13H9Br2N. Molecular Weight: 339.02. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528832: Ethyl (2E)-2-(1,3-benzodioxol-5-ylmethylene)hydrazinecarboxylate

Chemical compound data from PubChem database. IUPAC Name: 2,3-dimethoxypropyl 10-methyldodecanoate. Molecular Formula: C18H36O4. Molecular Weight: 316.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 525791: N-(3-Ethoxyphenyl)-N'-(3-chlorophenyl)formamidine

Chemical compound data from PubChem database. IUPAC Name: N-(3-bromophenyl)-N'-(3-ethoxyphenyl)methanimidamide. Molecular Formula: C15H15BrN2O. Molecular Weight: 319.2. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 527761: 2,2-Dichloroethyl hexanoate

Chemical compound data from PubChem database. IUPAC Name: 2,2-dichloroethyl hexanoate. Molecular Formula: C8H14Cl2O2. Molecular Weight: 213.1. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Doxazosin mesylate

Doxazosin Mesylate is a prescription medication available as oral tablets in strengths of 1mg, 2mg, 4mg, and 8mg. It belongs to the class of alpha-adrenergic blockers and is used to treat high blood pressure and symptoms of an enlarged prostate. Manufactured by Upsher-Smith Laboratories, LLC, under application ANDA209013. This information was generated using AI and is provided for informational and research purposes only.
Compound 525798: N-(4-Ethoxyphenyl)-N'-(4-chlorophenyl)formamidine

Chemical compound data from PubChem database. IUPAC Name: N'-(4-chlorophenyl)-N-(4-ethoxyphenyl)methanimidamide. Molecular Formula: C15H15ClN2O. Molecular Weight: 274.74. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Substantiation of Child Abuse and Neglect Reports, 1985

This study identifies factors that significantly increase or decrease the likelihood that a child maltreatment report will be substantiated once an investigation occurs.  A specific concern of the study was to investigate the size and nature of the difference in substantiation rates for reports originating from professional sources mandated by law to report suspected cases of child maltreatment compared to reports from non-professional sources, such as relatives and neighbors.  A representative sample of 796 sexual abuse, 198 physical abuse and 880 neglect reports were obtained from the New York State Child Abuse and Maltreatment Register.  Types of data collected included background variables (e.g., sex and age of the subject child); the source of the report; actions that took place after the report was filed (e.g., court action), and the case determination.

Investigators: Abstract
Patent AT-E399922-T1: [Translated] FASTENING DEVICE FOR A WALL PART OF A SHOWER CABIN

The device has an L-shaped longitudinal metal section (6) made of aluminum and having perpendicular wings (7, 8). Two parallel longitudinal grooves (9) extend vertically along the height of the section and have opposite inner walls with a toothed section, formed by parallel ridges (11) extending along the length of the grooves. The grooves receive screws adapted for the fixation of a panel (2) on the section.
Compound 526195: 4-Methoxy-2-methyl-2-butanethiol

Chemical compound data from PubChem database. IUPAC Name: 4-methoxy-2-methylbutane-2-thiol. Molecular Formula: C6H14OS. Molecular Weight: 134.24. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 529922: Nicardipine M (dehydro-desamino-hydroxy)

Chemical compound data from PubChem database. IUPAC Name: 3-O-(2-hydroxyethyl) 5-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate. Molecular Formula: C18H18N2O7. Molecular Weight: 374.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 525373: 2,4-Dimethyl-3,5-dithia-7-octene

Chemical compound data from PubChem database. IUPAC Name: 2-(1-prop-2-enylsulfanylethylsulfanyl)propane. Molecular Formula: C8H16S2. Molecular Weight: 176.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 530519: 5-Bromovaleric acid, hexadecyl ester

Chemical compound data from PubChem database. IUPAC Name: hexadecyl 5-bromopentanoate. Molecular Formula: C21H41BrO2. Molecular Weight: 405.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528140: 5-Isopropyl-3-methyl-2-(methylthio)pyrazine

Chemical compound data from PubChem database. IUPAC Name: 3-methyl-2-methylsulfanyl-5-propan-2-ylpyrazine. Molecular Formula: C9H14N2S. Molecular Weight: 182.29. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E401769-T1: [Translated] EXPANDABLE WEDGE AND SYSTEM COMPRISING A MODULE, A RECEIVER AND SUCH A WEDGE INTERMEDIATE

The invention concerns a wedge (12) comprising: a plate (13), and actuator (16) mounted on the plate (13) while being mobile relative thereto between an active position and an inactive position; a wedge element (19) mounted on the plate (13) and coupled to said actuator (16), said wedge element (19) being deformable between: an inactive configuration, adopted in inactive position of the actuator (16), wherein the wedge element (19) extends in the vicinity of the plate (13), and an active configuration, adopted in the active position of the actuator (16), wherein the wedge element (19) is in straight position while being at least locally spaced apart from the plate (13). The invention also concerns a system comprising a module, a receptacle and such a wedge interposed between them.
Compound 525426: 3,3,5,5-Tetramethyl-4-thiaheptane

Chemical compound data from PubChem database. IUPAC Name: 2-methyl-2-(2-methylbutan-2-ylsulfanyl)butane. Molecular Formula: C10H22S. Molecular Weight: 174.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E40009-T1: [Translated] DEVICE FOR THE ELECTROCHEMICAL ANALYSIS OF ELECTROLYTIC COMPONENTS IN A SAMPLE LIQUID.

The present invention provides a device for the electrochemical analysis of electrolytic components in a sample liquid (58), especially of a body fluid, with a selective measurement electrode (20) for a kind of ion to be analysed, a reference half cell, which includes a conducting-off element (30) cooperating in the operational state with a reference electrolyte (56), and a voltage measurement device (34) for the measurement of the voltage between the measurement electrode and the conducting-off element (30), wherein the measurement electrode (20) is arranged on a pipe (22) provided with a sucking-in opening (23) for the sample liquid (58), the conducting-off element (30) of the reference half cell being arranged on the pipe (22) in such a manner that it directly contacts a liquid (56) present therein, the conducting-off element (30) thereby being arranged in the pipe (22) in the sucking-in direction behind the measurement electrode (20), a sucking-in device (36) being provided through which a sample liquid (58) can be sucked in and, together with a liquid reference electrolyte present in the pipe (22) or previously sucked in, is transportable subsequent to this in the same direction in the pipe (22) and the voltage measurement device (34) is activatable in a measurement operational state in that the sample liquid (58) contacts the measurement electrode and the reference liquid (56) contacts the conducting-off element (30) and both liquids are in contact with one another, making possible an ion exchange.
CDC WONDER: Mortality - Multiple Cause of Death

<p>The Mortality - Multiple Cause of Death data on CDC WONDER are county-level national mortality and population data spanning the yehttps://healthdata.gov/d/2sz9-6c59ars 1999-2006. These data are available in two separate data sets: one data set for years 1999-2004 with 3 race groups, and another data set for years 2005-2006 with 4 race groups and 3 Hispanic origin categories. Data are based on death certificates for U.S. residents. Each death certificate contains a single underlying cause of death, up to twenty additional multiple causes, and demographic data. The number of deaths, crude death rates,  age-adjusted death rates, standard errors and 95% confidence intervals for death rates can be obtained by place of residence (total U.S., state, and county), age group (including infants), race, Hispanic ethnicity (years 2005-2006 only), sex, year of death, and cause-of-death (4-digit ICD-10 code or group of codes). The data are produced by the National Center for Health Statistics.</p>
The DAWN Report: Highlights of the 2010 Drug Abuse Warning Network (DAWN) Findings on Drug-Related Emergency Department Visits

This Drug Abuse Warning Network (DAWN) short report summarizes key findings about drug-related emergency department visits between 2004 and 2010. The report includes data for illicit drugs, alcohol, and prescription and over-the counter medications. For medications, the report looks at misuse and abuse, adverse reactions, and accidental ingestion of drugs by children.
Nucleolar localization of an isoform of the IGF-I precursor

Background
          Alternative exons encode different isoforms of the human insulin-like growth factor-I (IGF-I) precursor without altering mature IGF-I. We hypothesized that the various IGF-I precursors may traffic IGF-I differently. Chimeric IGF-I precursors were made with green fluorescent protein (GFP) cloned between the signal and mature IGF-I domains.
        
        
          Results
          Chimeras containing exons 1 or 2 were located in the cytoplasm, consistent with a secretory pathway, and suggesting that both exons encoded functional signal peptides. Exon 5-containing chimeras localized to the nucleus and strongly to the nucleolus, while chimeras containing exon 6 or the upstream portion of exon 5 did not. Nuclear and nucleolar localization also occurred when the mature IGF-I domain was deleted from the chimeras, or when signal peptides were deleted.
        
        
          Conclusions
          We have identified a nucleolar localization for an isoform of the human IGF-I precursor. The findings are consistent with the presence of a nuclear and nucleolar localization signal situated in the C-terminal part of the exon 5-encoded domain with similarities to signals in several other growth factors.
DOH Primary Care Service Areas

<div>[<a href='https://files.hawaii.gov/dbedt/op/gis/data/Primary_Care_Service_Areas.pdf' target='_blank' rel='nofollow ugc noopener noreferrer'>Metadata</a>]  Department of Health Primary Care Service Areas: Received from State Dept. of Health, December, 2019. <br /></div><div>Boundaries are based on census tracts. Primary care service areas were selected to describe the delivery of primary health services in the State of Hawai‘i through participation of multiple stakeholders in the early 1990’s. The rural health associations of the Hawai‘i, Maui and Kaua‘i Counties delineated rational service areas under their respective jurisdictions. The Needs Assessment Committee of the Primary Care Roundtable participated in the delineation of rational service areas... referred to as primary care service areas. Clustering of neighborhoods into these primary care service areas was intended to provide information below the county or island level with demarcation between adjacent neighborhoods. Census tracts were used in defining these areas due to their availability in census and vital statistic data. The size of the population in these areas, based on the 2010 u.S. Census data, vary from 170 individuals in Ni‘ihau and 2,291 in Hāna to 115,164 in Ko‘olaupoko. Thus direct comparisons in estimates between primary care service areas are limited. Clusters of census tracts were defined using both 2010 and 2000 census tracts depending on the data source. <br /></div><div><br /></div><div>For additional information, please refer to complete metadata at <a href='https://files.hawaii.gov/dbedt/op/gis/data/Primary_Care_Service_Areas.pdf' target='_blank' rel='nofollow ugc noopener noreferrer'>https://files.hawaii.gov/dbedt/op/gis/data/Primary_Care_Service_Areas.pdf</a> or contact Hawaii Statewide GIS Program, Office of Planning and Sustainable Development, State of Hawaii; PO Box 2359, Honolulu, HI 96804; (808) 587-2846; email: <a href='mailto:gis@hawaii.gov' target='_blank' rel='nofollow ugc noopener noreferrer'>gis@hawaii.gov</a>; Website: <a href='https://planning.hawaii.gov/gis' target='_blank' rel='nofollow ugc noopener noreferrer'>https://planning.hawaii.gov/gis</a>.</div>
Compound 527007: 1-Pentanamine, N-pentyl-N-propyl

Chemical compound data from PubChem database. IUPAC Name: N-pentyl-N-propylpentan-1-amine. Molecular Formula: C13H29N. Molecular Weight: 199.38. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 529869: 3-(2-Furfuryl)-2,5-dimethylpyrazine

Chemical compound data from PubChem database. IUPAC Name: 3-(furan-2-ylmethyl)-2,5-dimethylpyrazine. Molecular Formula: C11H12N2O. Molecular Weight: 188.23. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 527183: 1-(4a,8-dimethyl-4,5,6,7,8,8a-hexahydro-3H-naphthalen-2-yl)ethanone

Chemical compound data from PubChem database. IUPAC Name: 1-(4a,8-dimethyl-4,5,6,7,8,8a-hexahydro-3H-naphthalen-2-yl)ethanone. Molecular Formula: C14H22O. Molecular Weight: 206.32. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 530529: 5-Chlorovaleric acid, pentadecyl ester

Chemical compound data from PubChem database. IUPAC Name: pentadecyl 5-chloropentanoate. Molecular Formula: C20H39ClO2. Molecular Weight: 347.0. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Dynamic contrast-enhanced magnetic resonance imaging of the sarcopenic muscle

Background
          Studies about capillarity of the aged muscle provided conflicting results and no data are currently available about the magnetic resonance imaging (MRI) in vivo characteristics of the microvascular bed in aged rats. We have studied age-related modifications of the skeletal muscle by in vivo T2-relaxometry and dynamic contrast-enhanced magnetic resonance imaging (CE-MRI) at high field intensity (4.7 T). The aim of the work was to test the hypothesis that the ageing process involves microvessels in skeletal muscle.
        
        
          Methods
          The study was performed in 4-month-old (n = 6) and 20-month-old (n = 6) rats.
        
        
          Results
          At MRI examination, the relaxation time T2 of the gastrocnemius muscle showed no significant difference between these two groups. The kinetic of contrast penetration in the tissue showed that in 4-month-old rats the enhancement values of the signal intensity at different time-points were significantly higher than those found in senescent rats.
        
        
          Conclusion
          The reported finding suggests that there is a modification of the microcirculatory function in skeletal muscle of aged rats. This work also demonstrates that CE-MRI allows for an in vivo quantification of the multiple biological processes involving the skeletal muscle during aging. Therefore, CE-MRI could represent a further tool for the follow up of tissue modification and therapeutic intervention both in patients with sarcopenia and in experimental models of this pathology.
Patent AT-E400131-T1: [Translated] PROVIDING CERTIFICATE PASSAGES IN A SYSTEM AND METHOD FOR SEARCHING AND RETRIEVING CERTIFICATES

A system and method for searching and retrieving certificates, which may be used in the processing of encoded messages. In one broad aspect, a message management server generates certificate identification data from a message that uniquely identifies a certificate associated with the message. The certificate identification data can then be used to determine whether a given located certificate retrieved from one or more certificate servers in response to a certificate search request is the certificate associated with the message. Only the certificate identification data is needed to facilitate the determination at a user's computing device (e.g. a mobile device), alleviating the need for the user to download the entire message to the computing device in order to make the determination.
Compound 526509: 2-Isothiocyanato-3-(methylthio)propionic acid ethyl ester

Chemical compound data from PubChem database. IUPAC Name: ethyl 2-isothiocyanato-3-methylsulfanylpropanoate. Molecular Formula: C7H11NO2S2. Molecular Weight: 205.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
The liver is a common non-exocrine target in primary Sjögren's syndrome: A retrospective review

Background
          The autoimmune destruction of exocrine glands that defines primary Sjögren's syndrome (1°SS) often extends to non-exocrine organs including the liver. We aimed to determine the prevalence of liver disease in patients with 1°SS and to evaluate the association of this complication with other non-exocrine features and serologic markers of autoimmunity and systemic inflammation.
        
        
          Methods
          We reviewed 115 charts of patients with 1°SS and further analyzed the 73 cases that fulfilled the European Epidemiology Center Criteria, seeking evidence for clinical and subclinical liver disease.
        
        
          Results
          Liver function tests had been determined in 59 of the 73 patients. Of those, 29 patients (49.1%) had abnormal liver function tests including 20.3% with clinically overt hepatic disease. Liver disease was the most common non-exocrine feature in this cohort. Risk factors for abnormal liver function tests were distributed similarly between the patients with and without liver disease. In 60% of patients with abnormal liver function tests no explanation for this complication was found except for 1°SS. Liver involvement was significantly more common in 1°SS patients who also had evidence of lung, kidney and hematological abnormalities. Patients with abnormal liver function tests were also more likely to have an elevated sedimentation rate and a positive anti-ENA during the course of their disease.
        
        
          Conclusion
          Liver involvement is a common complication in 1°SS. Its presence correlates with systemic disease. We consider that this complication should be routinely sought in patients with 1°SS, especially when a positive anti-ENA or evidence of systemic inflammation is found.