AndreaBozzo/ceres-open-data-index huggingface dataset:
A C-terminal hydrophobic region is required for homo-oligomerization of the hepatitis E virus capsid (ORF2) protein

Hepatitis E virus (HEV) is the causative agent of hepatitis E, an
acute form of viral hepatitis. The open reading frame 2 (ORF2) of HEV encodes the viral capsid protein, which can self-oligomerize into virus-like particles. To understand the domains within this protein important for capsid biogenesis, we have carried out in vitro analyses of association and folding patterns of wild type and mutant ORF2 proteins. When expressed in vitro or in transfected cells, the ORF2
protein assembled as dimers, trimers and higher order forms. While
N-terminal deletions up to 111 amino acids had no effect, the deletion of amino acids 585–610 led to reduced homo-oligomerization. This deletion also resulted in aberrant folding of the protein, as determined by its sensitivity to trypsin. This study suggests that a C-terminal hydrophobic region encompassing amino acids 585–610 of the ORF2 protein might be critical for capsid biogenesis.
Can Australian general practitioners effectively screen for diabetic retinopathy? A pilot study

Background
          Diabetes has been identified as one of the national health priority areas in Australia. After 20 years of diabetes most patients can be expected to develop diabetic retinopathy which, if undetected, is likely to cause significant visual loss or blindness. This paper reports on a pilot study aimed to test the ability of Australian GPs to clinically recognise diabetic retinopathy following a brief training intervention.
        
        
          Method
          17 GPs from a Brisbane Division of General Practice were recruited to participate in a clinical upskilling intervention pilot. Participant scores on clinical assessments were used to analyse GP sensitivity and specificity in screening for diabetic retinopathy. Results were compared with the NHMRC guidelines for acceptable screening accuracy.
        
        
          Results
          Ten of the 17 GPs (59%) achieved a screening sensitivity of 25% or less in the pre test, three (18%) a sensitivity of 50%, and four (23%) achieved a sensitivity of ≥ 75%. In the post-test, all seventeen GPs achieved between 50 and 100% sensitivity. In the pre-test, thirteen (76%) GPs achieved a screening specificity of less than or equal to 50%, and four (23%) a specificity of 75 %. In the post test, four GPs (23%) rated a screening specificity of less than 50%, six (35%) achieved a specificity of 66%, and seven (41%) 100% specificity.
        
        
          Conclusion
          24% of GPs met the NHMRC diabetic retinopathy screening criterion prior to the workshop, and 94% following this brief training intervention. Australian GPs are capable of a much more significant role in community screening for diabetic retinopathy.
Genetic polymorphisms in lung disease: bandwagon or breakthrough?

The study of genetic polymorphisms has touched every aspect of pulmonary and critical care medicine. We review recent progress made using genetic polymorphisms to define pathophysiology, to identify persons at risk for pulmonary disease and to predict treatment response. Several pitfalls are commonly encountered in studying genetic polymorphisms, and this article points out criteria that should be applied to design high-quality genetic polymorphism studies.
County/Hospital Alert Tracking System (CHATS) - Maryland Institute for Emergency Medical Services Systems (MIEMSS)

This is an external link to the CHATS system on the website of MIEMSS, Maryland Institute for Emergency Medical Services Systems. CHATS is updated every 60 seconds. CHATS shows and generates reports on the current status of hospitals and counties in Maryland, including real-time listings of Yellow Alerts and Red Alerts by hospital. The backing data are in an internal MIEMSS SQL database. The CHATS site is powered by Global Emergency Resources, LLC.
CCWIS Transition Period Presentation

This presentation describes the Comprehensive Child Welfare Information System (CCWIS) Transition Period as defined by Federal Regulation 45 CFR 1355.56 as well as submission requirements as defined by Federal Regulation 45 CFR 1355.52(i). It provides an overview of the options available to title IV-E agencies during the transition period and what is required of them by the end it.

Metadata-only record linking to the original dataset. Open original dataset below.
Compound 527835: Proline, N-methyl-, butyl ester

Chemical compound data from PubChem database. IUPAC Name: butyl 1-methylpyrrolidine-2-carboxylate. Molecular Formula: C10H19NO2. Molecular Weight: 185.26. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Levocarnitine

Levocarnitine is a prescription oral solution used to supplement carnitine, a substance that helps the body convert food into energy. Manufactured by Rising Pharma Holdings, Inc., this generic drug comes in a 118 mL plastic bottle with a strength of 1 g per 10 mL. It's classified as a carnitine analog and is approved under ANDA076851. This information was generated using AI and is provided for informational and research purposes only.
Managed Care Individual Provider Network Data: September 30, 2012

The primary purpose for the Provider Network Data System is to collect data needed to evaluate the provider networks including physicians, hospitals, labs, home health agencies, durable medical equipment providers, etc., for all types of Managed Care plans in New York State, including HIV Special Need Plans (SNP), Family Health Plus (FHP) Buy-In, Programs of All-Inclusive Care for the Elderly (PACE), and Non-PACE Managed Long-Term Care (MLTC) plans.

This dataset reflects individual provider data.

Provider Network Data System information is self reported.

For more information, go to http://www.health.ny.gov/health_care/managed_care/.
Compound 526634: (3-Acetyloxy-4-methoxyoxolan-2-yl)methyl acetate

Chemical compound data from PubChem database. IUPAC Name: (3-acetyloxy-4-methoxyoxolan-2-yl)methyl acetate. Molecular Formula: C10H16O6. Molecular Weight: 232.23. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Adoption and Foster Care Analysis and Reporting System (AFCARS)

The Adoption and Foster Care Analysis and Reporting System (AFCARS) is a federally mandated data collection system intended to provide case specific information on all children covered by the protections of Title IV-B/E of the Social Security Act (Section 427). Under the Final 1993 AFCARS’ rule, states are required to collect and submit data on all children who are under the responsiblity of the title IV-B/IV-E agency for placement, care, or supervision.

<b>Units of Response: </b>Children in Foster Care

<b>Type of Data: </b>Administrative

<b>Tribal Data: </b>Unavailable

<b>Periodicity: </b>Semiannual

<b>Demographic Indicators: </b>Disability;Geographic Areas;Sex

<b>SORN: </b>https://www.federalregister.gov/documents/2016/12/14/2016-29366/adoption-and-foster-care-analysis-and-reporting-system

<b>Data Use Agreement: </b>https://www.ndacan.acf.hhs.gov/datasets/order_forms/termsofuseagreement.pdf

<b>Data Use Agreement Location: </b>https://www.ndacan.acf.hhs.gov/datasets/order_forms/termsofuseagreement.pdf

<b>Granularity: </b>Individual

<b>Spatial: </b>United States

<b>Geocoding: </b>FIPS Code
Compound 526317: 2,3,4-Tribromo-dibenzofuran

Chemical compound data from PubChem database. IUPAC Name: 2,3,4-tribromodibenzofuran. Molecular Formula: C12H5Br3O. Molecular Weight: 404.88. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Efficient adenovirus-mediated gene transfer into primary T cells and thymocytes in a new coxsackie/adenovirus receptor transgenic model

Background
          Gene transfer studies in primary T cells have suffered from the limitations of conventional viral transduction or transfection techniques. Replication-defective adenoviral vectors are an attractive alternative for gene delivery. However, naive lymphocytes are not readily susceptible to infection with adenoviruses due to insufficient expression of the coxsackie/adenovirus receptor.
        
        
          Results
          To render T cells susceptible to adenoviral gene transfer, we have developed three new murine transgenic lines in which expression of the human coxsackie/adenovirus receptor (hCAR) with a truncated cytoplasmic domain (hCARΔcyt) is limited to thymocytes and lymphocytes under direction of a human CD2 mini-gene. hCARΔcyt.CD2 transgenic mice were crossed with DO11.10 T cell receptor transgenic mice (DO11.hCARΔcyt) to allow developmental studies in a defined, clonal T cell population. Expression of hCARΔcyt enabled adenoviral transduction of resting primary CD4+ T cells, differentiated effector T cells and thymocytes from DO11.hCARΔcyt with high efficiency. Expression of hCARΔcyt transgene did not perturb T cell development in these mice and adenoviral transduction of DO11.hCARΔcyt T cells did not alter their activation status, functional responses or differentiative potential. Adoptive transfer of the transduced T cells into normal recipients did not modify their physiologic localization.
        
        
          Conclusion
          The DO11.hCARΔcyt transgenic model thus allows efficient gene transfer in primary T cell populations and will be valuable for novel studies of T cell activation and differentiation.
Everolimus

Everolimus is an oral prescription medication that acts as an immunosuppressant and mTOR inhibitor, used to prevent organ rejection in transplant patients and treat certain cancers or conditions like tuberous sclerosis. Available as tablets in strengths of 0.25mg, 0.5mg, 0.75mg, and 1mg, manufactured by Hikma Pharmaceuticals USA Inc. This information was generated using AI and is provided for informational and research purposes only.
Compound 525275: N'-(4-iodo-phenyl)-N,N-dimethyl-formamidine

Chemical compound data from PubChem database. IUPAC Name: N'-(3-iodophenyl)-N,N-dimethylmethanimidamide. Molecular Formula: C9H11IN2. Molecular Weight: 274.1. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
2021-2022 NSDUH: Guide to Comparison of Population Percentages Across Geographies

Learn how to access and use p-value tables to compare state-level estimates from the 2021-2022 National Surveys on Drug Use and Health (NSDUH). Thep-value tablesaccompany the2021-2022 NSDUH State Estimates of Substance Use and Mental Disorderswhich contain 35 measures of substance use and mental health across the nation, four Census regions, 50 states, and the District of Columbia. The guide describes the files and how to use the p-value tables to determine whether differences between two geographic areas are statistically significant.
Patent AT-E401791-T1: [Translated] FUNGICIDAL COMPOSITION COMPRISING A PYRIDYLETHYLBENZAMIDE DERIVATIVE AND A COMPOUND WHICH CAN INHIBIT SPOR GERMINATION OR MYCELIUM GROWTH BY ACTING ON VARIOUS METABOLIC PATHWAYS

A composition comprising at least a pyridylethylbenzamide derivative of general formula (I) (a) and a compound capable of inhibiting the spores germination or mycelium growth by acting on different metabolic routes (b) in a (a) / (b) weight ratio of from 0.01 to 20. <??>A composition further comprising an additional fungicidal compound. <??>A method for preventively or curatively combating the phytopathogenic fungi of crops by using this composition.
NO-independent regulatory site of direct sGC stimulators like YC-1 and BAY 41-2272

Background
          The most important receptor for nitic oxide is the soluble guanylate cyclase (sGC), a heme containing heterodimer. Recently, a pyrazolopyridine derivative BAY 41-2272, structurally related to YC-1, was identified stimulating soluble guanylate cyclase in an NO-independent manner, which results in vasodilatation and antiplatelet activity. The study described here addresses the identification of the NO-independent site on soluble guanylate cyclase.
        
        
          Results
          We developed a photoaffinity label (3H-meta-PAL) for the direct and NO-independent soluble guanylate cyclase (sGC) stimulator BAY 41-2272 by introducing an azido-group into the tritium labeled compound. The synthesized photoaffinitylabel directly stimulates the purified sGC and shows in combination with NO a synergistic effect on sGC activity. Irradiation with UV light of 3H-meta-PAL together with the highly purified sGC leads to a covalent binding to the α1-subunit of the enzyme. This binding is blocked by unlabeled meta-PAL, YC-1 and BAY 41-2272. For further identification of the NO-independent regulatory site the 3H-meta-PAL labeled sGC was fragmented by CNBr digest. The 3H-meta-PAL binds to a CNBr fragment, consisting of the amino acids 236–290 of the α1-subunit. Determination of radioactivity of the single PTH-cycles from the sequencing of this CNBr fragment detected the cysteines 238 and 243 as binding residues of the 3H-meta-PAL.
        
        
          Conclusions
          Our data demonstrate that the region surrounding the cysteines 238 and 243 in the α1-subunit of the sGC could play an important role in regulation of sGC activity and could be the target of this new type of sGC stimulators.
Compound 525097: 1,3-Dichloroisopropyl isobutyrate

Chemical compound data from PubChem database. IUPAC Name: 1,2-dichloropropan-2-yl 2-methylpropanoate. Molecular Formula: C7H12Cl2O2. Molecular Weight: 199.07. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Results from the 2011 National Survey on Drug Use and Health: Mental Health Findings

This page presents the report and detailed tables pertaining to mental health from the 2011 National Survey on Drug Use and Health (NSDUH). Both the report and detailed tables present national estimates of the prevalence of past year mental disorders and past year mental health service utilization for youths aged 12 to 17 and adults aged 18 or older. Among adults, estimates presented include rates and numbers of persons with any mental illness (AMI), serious mental illness (SMI), suicidal thoughts and behavior, major depressive episode (MDE), treatment for depression (among adults with MDE), and mental health service utilization. Estimates for youths include MDE, treatment for depression (among youths with MDE), and mental health service utilization. Measures related to the co-occurrence of mental disorders with substance use or with substance use disorders also are presented for both adults and youths. Results are provided for age group, gender, race/ethnicity, education level, employment status, poverty level, geographic area, insurance status. Comparisons are made between 2011 and 2002 to 2010.
Compound 525440: 3,7-Dimethyl-4,6-dithianonane

Chemical compound data from PubChem database. IUPAC Name: 2-(butan-2-ylsulfanylmethylsulfanyl)butane. Molecular Formula: C9H20S2. Molecular Weight: 192.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528215: Benzoic acid, 2-hydroxy-6-methyl-3-(1-methylethyl), DTBS

Chemical compound data from PubChem database. IUPAC Name: 2,2-ditert-butyl-5-methyl-8-propan-2-yl-1,3,2-benzodioxasilin-4-one. Molecular Formula: C19H30O3Si. Molecular Weight: 334.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 527016: alpha-Methyl butanoyl fentanyl

Chemical compound data from PubChem database. IUPAC Name: N-phenyl-N-[1-(1-phenylpropan-2-yl)piperidin-4-yl]butanamide. Molecular Formula: C24H32N2O. Molecular Weight: 364.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E400570-T1: [Translated] 2,4,6-TRISUBSUTITUTED PYRIMIDINES AS INHIBITORS OF PHOSPHATIDYLINOSITE (PI)3-KINASE AND THEIR USE IN THE TREATMENT OF CANCER

The invention concerns pyrimidine derivatives of Formula (I) wherein each of p, R<SUP>1</SUP>, R<SUP>2</SUP>, q, R<SUP>3</SUP>, r, R<SUP>4</SUP>, X<SUP>1 </SUP>and Q<SUP>1 </SUP>have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the production of an anti-proliferative effect in a warm-blooded animal such as man.
Compound 525261: N''-Pentyl-N,N,N',N'-tetramethyl-guanidine

Chemical compound data from PubChem database. IUPAC Name: 1,1,3,3-tetramethyl-2-pentylguanidine. Molecular Formula: C10H23N3. Molecular Weight: 185.31. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 526784: 8-Hydroxy-arachidic, methyl ester, tBDMS ether

Chemical compound data from PubChem database. IUPAC Name: methyl 8-[tert-butyl(dimethyl)silyl]oxyicosanoate. Molecular Formula: C27H56O3Si. Molecular Weight: 456.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Tobacco Product and Alcohol Use Tables (Prevalence Estimates) - 2.1 to 2.84

These detailed tables are population tobacco and alcohol use totals and prevalence estimates from the 2010 National Survey on Drug Use and Health (NSDUH). Tobacco products include cigarettes, smokeless tobacco, cigars, and pipe tobacco. Alcohol use includes binge and heavy alcohol use. Results are provided for lifetime, past year, and past month use by age group, gender, race/ethnicity, education level, employment status, and geographic area. Comparisons are made between 200 and 2009.
Compound 527786: Benzoic acid, 2-chloro, 4-pentenyl ester

Chemical compound data from PubChem database. IUPAC Name: pent-4-enyl 2-chlorobenzoate. Molecular Formula: C12H13ClO2. Molecular Weight: 224.68. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Fluphenazine hydrochloride

Fluphenazine Hydrochloride is a prescription injectable medication used to treat schizophrenia and other mental health conditions. It belongs to the phenothiazine class of drugs and is administered as an intramuscular injection at a strength of 2.5 mg/mL. Manufactured by Fresenius Kabi USA, LLC, it's available in a 10 mL vial. This information was generated using AI and is provided for informational and research purposes only.
Northeast (NE)

This report presents the Northeast\'s (e.g., combines Connecticut, Maine, Massachusetts, New Hampshire, New Jersey, New York, Pennsylvania, Rhode Island, and Vermont) estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for the Northeast for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.
CDC STATE System E-Cigarette Legislation - Youth Access

1995-2024. Centers for Disease Control and Prevention (CDC). State Tobacco Activities Tracking and Evaluation (STATE) System. E-Cigarette Legislation—Youth Access. The STATE System houses current and historical state-level legislative data on tobacco use prevention and control policies.  Data are reported on a quarterly basis. Data include information related to restrictions, enforcement and penalties associated with the sale of e-cigarettes to youth through retail sales and vending machines.
Patent AT-E401417-T1: [Translated] CAT PANCREAS LIPASE COMPOSITION AND METHOD FOR PREPARING AND USING SUCH COMPOSITION

A novel form of lipase, namely feline pancreatic lipase (also termed feline classical pancreatic lipase) has an N-terminal amino acid sequence as shown in SEQ ID NO. 1. A method of purifying this lipase includes collecting pancreatic tissue from cats, delipidating the pancreatic tissue to produce a delipidated pancreatic extract, extracting pancreatic lipase from the delipidated pancreatic extract, and eluting the extracted pancreatic lipase through various columns. This lipase can be used for measuring pancreatic lipase immunoreactivity in serum thereby diagnosing pancreatitis in cats. To do so, antiserum against feline pancreatic lipase is prepared, and immunoassays are then performed in serum samples using this antiserum. In the event that increased concentration of pancreatic lipase immunoreactivity above the control range is detected in the serum, the cat might have pancreatitis.
Interactive decision support in hepatic surgery

Background
          Hepatic surgery is characterized by complicated operations with a significant peri- and postoperative risk for the patient. We developed a web-based, high-granular research database for comprehensive documentation of all relevant variables to evaluate new surgical techniques.
        
        
          Methods
          To integrate this research system into the clinical setting, we designed an interactive decision support component. The objective is to provide relevant information for the surgeon and the patient to assess preoperatively the risk of a specific surgical procedure.
          Based on five established predictors of patient outcomes, the risk assessment tool searches for similar cases in the database and aggregates the information to estimate the risk for an individual patient.
        
        
          Results
          The physician can verify the analysis and exclude manually non-matching cases according to his expertise. The analysis is visualized by means of a Kaplan-Meier plot.
          To evaluate the decision support component we analyzed data on 165 patients diagnosed with hepatocellular carcinoma (period 1996–2000). The similarity search provides a two-peak distribution indicating there are groups of similar patients and singular cases which are quite different to the average. The results of the risk estimation are consistent with the observed survival data, but must be interpreted with caution because of the limited number of matching reference cases.
        
        
          Conclusion
          Critical issues for the decision support system are clinical integration, a transparent and reliable knowledge base and user feedback.
Compound 528241: 1,2,3,4,5,6-Hexamethylcyclohexane

Chemical compound data from PubChem database. IUPAC Name: 1,2,3,4,5,6-hexamethylcyclohexane. Molecular Formula: C12H24. Molecular Weight: 168.32. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.