AndreaBozzo/ceres-open-data-index huggingface dataset:
SNP analysis of the inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) gene by a fluorescence-adapted SSCP method

Background
          Single-nucleotide polymorphisms (SNPs) are considered to be useful polymorphic markers for genetic studies of polygenic traits. Single-stranded conformational polymorphism (SSCP) analysis has been widely applied to detect SNPs, including point mutations in cancer and congenital diseases. In this study, we describe an application of the fluorescent labeling of PCR fragments using a fluorescent-adapted primer for SSCP analysis as a novel method.
        
        
          Methods
          Single-nucleotide polymorphisms (SNPs) of the inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) gene were analyzed using a fluorescence-adapted SSCP method. The method was constructed from two procedures: 1) a fluorescent labeling reaction of PCR fragments using fluorescence-adapted primers in a single tube, and 2) electrophoresis on a non-denaturing polyacrylamide gel.
        
        
          Results
          This method was more economical and convenient than the single-stranded conformational polymorphism (SSCP) methods previously reported in the detection of the labeled fragments obtained. In this study, eight SNPs of the IHRP gene were detected by the fluorescence-adapted SSCP. One of the SNPs was a new SNP resulting in an amino acid substitution, while the other SNPs have already been reported in the public databases. Six SNPs of the IHRP were associated with two haplotypes.
        
        
          Conclusions
          The fluorescence-adapted SSCP was useful for detecting and genotyping SNPs.
Compound 530356: 2-Tert-butyl-1-methylcyclohexan-1-ol

Chemical compound data from PubChem database. IUPAC Name: 2-tert-butyl-1-methylcyclohexan-1-ol. Molecular Formula: C11H22O. Molecular Weight: 170.29. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Assessing the heritability of attentional networks

Background
          Current efforts to study the genetics of higher functions have been lacking appropriate phenotypes to describe cognition. One of the problems is that many cognitive concepts for which there is a single word (e.g. attention) have been shown to be related to several anatomical networks. Recently we have developed an Attention Network Test (ANT) that provides a separate measure for each of three anatomically defined attention networks. In this small scale study, we ran 26 pairs of MZ and DZ twins in an effort to determine if any of these networks show sufficient evidence of heritability to warrant further exploration of their genetic basis.
        
        
          Results
          The efficiency of the executive attention network, that mediates stimulus and response conflict, shows sufficient heritability to warrant further study. Alerting and overall reaction time show some evidence for heritability and in our study the orienting network shows no evidence of heritability.
        
        
          Conclusions
          These results suggest that genetic variation contributes to normal individual differences in higher order executive attention involving dopamine rich frontal areas including the anterior cingulate. At least the executive portion of the ANT may serve as a valid endophenotype for larger twin studies and subsequent molecular genetic analysis in normal subject populations.
Compound 525414: 2-Methyl-4,6-dithianonane

Chemical compound data from PubChem database. IUPAC Name: 2-methyl-1-(propylsulfanylmethylsulfanyl)propane. Molecular Formula: C8H18S2. Molecular Weight: 178.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Program Instruction (PI-15-09)

The purpose of this Program Instruction (PI) is to provide State, Territorial and Tribal title IV-E agencies (hereafter, "title IV-E agencies") with the revised form and instructions approved by the U.S. Office of Management and Budget (OMB) for reporting quarterly financial information on the title IV-E Foster Care, Adoption Assistance and Guardianship Assistance Programs.  This PI also provides guidance for the submission of the Annual Adoption Savings Calculation and Accounting Report for federal fiscal year (FFY) 2015 and for subsequent FFYs.

ATTACHMENT B - FORM CB-496: TITLE IV-E PROGRAMS QUARTERLY FINANCIAL REPORT: PART 1: EXPENDITURES and ESTIMATES (Including Caseload Data)
(This attachment cannot be posted at this time. To request a copy of the form, please email Angelique Brown at angelique.brown@acf.hhs.gov).

ATTACHMENT C - INSTRUCTIONS TO COMPLETE FORM CB-496 (A new version of this attachment, updated August 1, 2016, is available for download below).

ATTACHMENT D - FORM CB-496: TITLE IV-E PROGRAMS QUARTERLY FINANCIAL REPORT: PART 4: ANNUAL ADOPTION SAVINGS CALCULATION AND ACCOUNTING REPORT
(This attachment cannot be posted at this time. To request a copy of the form, please email Angelique Brown at angelique.brown@acf.hhs.gov).

Metadata-only record linking to the original dataset. Open original dataset below.
Multi-Site Evaluation of Foster Youth Programs (Chafee Independent Living Evaluation Project), 2001-2010

The Children’s Bureau in the Administration for Children and Families contracted with the Urban Institute and its partners—the Chapin Hall Center for Children at the University of Chicago and the National Opinion Research Center—to conduct an evaluation of selected programs funded through John Chafee Foster Care Independence Program (CFCIP). This evaluation, using a rigorous, random assignment design, was called for in the Foster Care Independence Act of 1999. 
The goal of the evaluation is to determine the effects of Independent Living Programs funded under CFCIP in achieving key outcomes for participating youth including increased educational attainment, higher employment rates and stability, greater interpersonal and relationship skills, reduced non-marital pregnancy and births, and reduced delinquency and crime rates. An initial evaluability assessment was conducted to identify programs that could be rigorously evaluated and to develop an evaluation design that would meet the requirements of the authorizing legislation. Programs participating in the evaluation include an employment services program in Kern County, California; a one-on-one intensive, individualized life skills program in Massachusetts; and, a tutoring/mentoring program and a classroom-based life skills training program, both in Los Angeles County, California.

Investigators: Mark E. Courtney, Ph.D.
University of Wisconsin Madison, WI

Matthew W. Stagner, Ph.D.
U.S. Department of Health and Human Services Washington, DC

Michael Pergamit, Ph.D.
Urban Institute Washington, DC
Patent AT-E400719-T1: [Translated] LOCK FOR A HORIZONTAL TOOL BOX

A lock system for a horizontal tool box wherein the latching mechanism for the lid may be operated from the proximal end of the toolbox and locking is achieved by means of a single padlock which is likewise located at the proximal end of the toolbox. An elongated latch rod is slidably disposed adjacent a front wall of either the body or lid components of the box. The padlock and the elongated latch rod are disposed such that the padlock body blocks the longitudinal movement of the proximal end of the latch rod and maintains the latch rod in the latched position when the body components are in the closed position and the padlock is locked, but the proximal end of the latch rod passes between the shackle and the padlock body to move the latch rod to the release position when the padlock is unlocked.
2015 CMHS Uniform Reporting System (URS) Table for Pennsylvania

2015 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Pennsylvania. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
Illinois AFCARS Assessment Review

Should you require access to this document or accessibility assistance with any documentation from Illinois's Adoption and Foster Care Analysis and Reporting System (AFCARS) assessment review, please contact us at cbwebsite@childwelfare.gov.This webpage includes the documentation from Illinois's Adoption and Foster Care Analysis and Reporting System (AFCARS) assessment review for fiscal year 2010:

AFCARS Assessment Review Findings – Letter (PDF - 33 KB)

AFCARS Assessment Review Report – Illinois (PDF - 74 KB)

AFCARS Case File Summary Report – Illinois (PDF - 23 KB)

AFCARS Assessment Review Findings – General Requirement (PDF - 99 KB)

AFCARS Assessment Review Findings – Foster Care and Adoption Data Elements (PDF - 352 KB)

AFCARS Assessment Review Case File Findings – Foster Care and Adoption Data Elements (PDF - 195 KB)

AFCARS Assessment Review Improvement Plan – General Requirements (PDF - 64 KB)

AFCARS Assessment Review Improvement Plan - Foster Care and Adoption Data Elements (PDF - 475 KB)

Metadata-only record linking to the original dataset. Open original dataset below.
Skeletal muscle dysfunction in chronic obstructive pulmonary disease

It has become increasingly recognized that skeletal muscle dysfunction is common in patients with chronic obstructive pulmonary disease (COPD). Muscle strength and endurance are decreased, whereas muscle fatigability is increased. There is a reduced proportion of type I fibers and an increase in type II fibers. Muscle atrophy occurs with a reduction in fiber cross-sectional area. Oxidative enzyme activity is decreased, and measurement of muscle bioenergetics during exercise reveals a reduced aerobic capacity. Deconditioning is probably very important mechanistically. Other mechanisms that may be of varying importance in individual patients include chronic hypercapnia and/or hypoxia, nutritional depletion, steroid usage, and oxidative stress. Potential therapies include exercise training, oxygen supplementation, nutritional repletion, and administration of anabolic hormones.
Compound 530381: Acetophenone, 4-hydroxy-3,5-dimethoxy, O-methyloxime

Chemical compound data from PubChem database. IUPAC Name: 2,6-dimethoxy-4-(N-methoxy-C-methylcarbonimidoyl)phenol. Molecular Formula: C11H15NO4. Molecular Weight: 225.24. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Managed Care Individual Provider Network Data: March 31, 2016

The primary purpose for the Provider Network Data System is to collect data needed to evaluate the provider networks including physicians, hospitals, labs, home health agencies, durable medical equipment providers, etc., for all types of Managed Care plans in New York State, including HIV Special Need Plans (SNP), Family Health Plus (FHP) Buy-In, Programs of All-Inclusive Care for the Elderly (PACE), and Non-PACE Managed Long-Term Care (MLTC) plans. This dataset reflects individual provider data. Provider Network Data System information is self-reported. For more information, check out http://www.health.ny.gov/health_care/managed_care/.
Clinical review: Status epilepticus

Status epilepticus (SE) has an annual incidence exceeding 100,000 cases in the United States alone, of which more than 20% result in death. Thus, increased awareness of presentation, etiologies, and treatment of SE is essential in the practice of critical care medicine. This review discusses current definitions of SE, as well as its clinical presentation and classification. The recent literature on epidemiology is reviewed, including morbidity and mortality data. An overview of the systemic pathophysiologic effects of SE is presented. Finally, significant studies on the treatment of acute SE and refractory SE are reviewed, including the use of anticonvulsants, such as benzodiazepines, and other drugs.
Compound 526651: Pb(II) N,N-bis(2,2,2-trifluoroethyl)dithiocarbamate, chelate

Chemical compound data from PubChem database. IUPAC Name: bis[bis(2,2,2-trifluoroethyl)carbamothioylsulfanyl]lead. Molecular Formula: C10H8F12N2PbS4. Molecular Weight: 719.0. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
2013 CMHS Uniform Reporting System (URS) Tables for Connecticut

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for Connecticut for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
Compound 525475: 4,7-Dithia-1-octene

Chemical compound data from PubChem database. IUPAC Name: 3-(2-methylsulfanylethylsulfanyl)prop-1-ene. Molecular Formula: C6H12S2. Molecular Weight: 148.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528979: 1,2-Hexacosanediol, di-TMS

Chemical compound data from PubChem database. IUPAC Name: trimethyl(1-trimethylsilyloxyhexacosan-2-yloxy)silane. Molecular Formula: C32H70O2Si2. Molecular Weight: 543.1. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Environmental Radiation Surveillance Indian Point Readings: Beginning 2009

This dataset measures the air and water near Indian Point and other locations(background) around NYS to determine the normal levels of radioactivity and monitors the influence of human activities on these levels.  The site numbers represent the location from which samples are collected.  

This dataset is not designed, or intended to monitor releases from discharge points at a specific facility (e.g., a stack). The facility operator performs this type of monitoring to meet the requirements of its licensing agency (e.g., a federal agency or the New York State Department of Environmental Conservation).   A column has been added for values which can be graphed.  Readings where a less than value is displayed show a value that is less than the detection limit of the measurement method and are essentially equivalent to 0.  Variations in detection limit are due to variations in sample collection and measurement instrument performance.
FY 2024 HHS Contingency Staffing Plan for a Lapse in Appropriation

As shown on the summary table, HHS’ contingency plans for agency operations in the absence of appropriations will lead to retaining 51,901 staff and furloughing 35,074 staff as of day two of a funding hiatus. Put another way, 60% of HHS employees will be retained and 40% will be furloughed. These percentages vary among HHS Operating Divisions and offices. Operating Divisions with a substantial direct service component will have more of their staff retained. For example, the NIH Clinical Center will continue to care for patients and admit new patients for whom it is medically necessary. FDA will continue core functions to handle and respond to emergencies – such as monitoring for and quickly responding to outbreaks related to foodborne illness and the flu, supporting food and medical product recalls when products endanger consumers and patients, pursuing criminal and certain civil investigations when we believe public health is at risk, screening the food and medical products that are imported to the U.S. to protect consumers and patients from harmful products, and addressing other critical public health issues.

Footnote in data
1/ This categorization does not reflect the total number of Commission Corps personnel at HHS, which is 3,949 total staff among all HHS operating and staff divisions.
Compound 526174: Dimethyl 4-chlorophenyl phosphate

Chemical compound data from PubChem database. IUPAC Name: (4-chlorophenyl) dimethyl phosphate. Molecular Formula: C8H10ClO4P. Molecular Weight: 236.59. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 525527: (3-Chloro-4-cyclohexyloxy-phenyl)-acetic acid, methyl ester

Chemical compound data from PubChem database. IUPAC Name: methyl 2-(3-chloro-4-cyclohexyloxyphenyl)acetate. Molecular Formula: C15H19ClO3. Molecular Weight: 282.76. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E400261-T1: [Translated] USE OF HISTONE DEACETYLASE INHIBITORS TO INCREASE THERAPEUTIC EFFECTS IN RADIOTHERAPY AND CHEMOTHERAPY

The present invention provides compositions and methods for increasing therapeutic gain in radiotherapy and chemotherapy for proliferating malignant or nonmalignant disease to produce high probability of tumor control with low frequency of sequelae of therapy by administering a therapeutically effective amount of a histone deacetylase inhibitor. The compounds are capable of simultaneously stimulating the epithelium regrowth, inhibiting the fibroblast proliferation, decreasing the collagen deposit, suppressing the fibrogenic growth factor, subsiding the proinflammatory cytokine and modulating the expression of cell cycle genes, tumor suppressors and oncogenes, and are useful to increase the therapeutic gain in radiotherapy and chemotherapy, which results in decrease of skin swelling and inflammation, promotion of epithelium healing in mucosa and dermis, decrease of xerostomia, prevention/reduction of severity of plantar-palmar syndrome, prevention of tissue fibrosis, ulceration, necrosis and tumorigenesis, and increase of tumor growth inhibition and tumor therapy effectiveness. <IMAGE> <IMAGE> <IMAGE> <IMAGE> <IMAGE> <IMAGE>
Patent AT-E399997-T1: [Translated] ELECTROWETTING CELL AND METHOD FOR PRODUCING THE SAME

The electrowetting cell ( 15 ) comprises an outer wall ( 90 ) and an inner wall ( 80 ), said outer wall ( 90 ) being provided with extensions ( 85, 86 ) extending at opposing sides of the inner wall ( 80 ). The cell ( 15 ) is further provided with a membrane ( 45 ) for volume expansion and is sealed through an electroplated layer ( 95 ).
Mutant Rab24 GTPase is targeted to nuclear inclusions

Background
          Members of the Rab GTPase family regulate intracellular protein trafficking, but the specific function of Rab24 remains unknown. Several attributes distinguish this protein from other members of the Rab family, including a low intrinsic GTPase activity.
        
        
          Results
          The functions of other Rab proteins have been defined through the use of dominant-negative mutants with amino acid substitutions in the conserved N(T)KxD nucleotide binding motif. Surprisingly, when such Rab24 constructs were expressed in cultured cells, they accumulated in nuclear inclusions which disrupted the integrity of the nuclear envelope. The inclusions reacted positively with antibodies against ubiquitin and Hsp70, similar to protein aggregates observed in polyglutamine disorders. They also appeared to sequester importin-β and GFP-coupled glucocorticoid receptor. Other Rab GTPases with similar mutations in the N(T)KxD motif were never found in inclusions, suggesting that the unusual localization of Rab24 is not related solely to misfolding of its nucleotide-free form. Studies with Rab24/Rab1B chimeras indicated that targeting of the mutant protein to inclusions requires the unique C-terminal domain of Rab24.
        
        
          Conclusion
          These studies demonstrate that mutations in Rab24 can trigger a cytopathic cellular response involving accumulation of nuclear inclusions. If the N(T)KxD mutants of Rab24 function as dominant suppressors, these studies may point to a unique role for Rab24 in degradation of misfolded cellular proteins or trafficking of proteins to the nuclear envelope. However, we cannot yet eliminate the possibility that these phenomena are related to unusual non-physiological protein interactions with the mutant form of Rab24.
Managed Care Individual Provider Network Data: December 31, 2013

The primary purpose for the Provider Network Data System is to collect data needed to evaluate the provider networks including physicians, hospitals, labs, home health agencies, durable medical equipment providers, etc., for all types of Managed Care plans in New York State, including HIV Special Need Plans (SNP), Family Health Plus (FHP) Buy-In, Programs of All-Inclusive Care for the Elderly (PACE), and Non-PACE Managed Long-Term Care (MLTC) plans. For more information, check out:  http://www.health.ny.gov/health_care/managed_care/ or go to the “About” tab.
Compound 526302: 1,8-Dibromo-dibenzofuran

Chemical compound data from PubChem database. IUPAC Name: 1,8-dibromodibenzofuran. Molecular Formula: C12H6Br2O. Molecular Weight: 325.98. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.