AndreaBozzo/ceres-open-data-index huggingface dataset:
Idaho (ID)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Idaho for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.
2018 Methodological Summary and Definitions

This report summarizes the 2018 NSDUH methods and other supporting information relevant to estimates of substance use and mental health issues, and organized into five chapters. Chapter 1 is an introduction to the report. Chapter 2 describes the survey, including information about the sample design; data collection procedures; and key aspects of data processing, such as development of analysis weights. Chapter 3 presents technical details on the statistical methods and measurement, such as suppression criteria for unreliable estimates, statistical testing procedures, and issues for selected substance use and mental health measures. Chapter 4 covers special topics related to prescription psychotherapeutic drugs. Chapter 5 describes other sources of data on substance use and mental health issues, including data sources for populations outside the NSDUH target population. Appendix A is a glossary that covers key definitions for use as a resource with the 2018 NSDUH reports and detailed tables. Appendix B provides a list of contributors to the report.
Compound 529741: Methyl 3,3,3-trichloro-2-hydroxypropanoate

Chemical compound data from PubChem database. IUPAC Name: methyl 3,3,3-trichloro-2-hydroxypropanoate. Molecular Formula: C4H5Cl3O3. Molecular Weight: 207.43. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528313: Pyrazine, 3-butyl-2-methoxy

Chemical compound data from PubChem database. IUPAC Name: 2-butyl-3-methoxypyrazine. Molecular Formula: C9H14N2O. Molecular Weight: 166.22. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
How long should angiotensin-converting enzyme inhibitors be given to patients following myocardial infarction: implications of the HOPE trial

Long-term treatment with angiotensin-converting enzyme inhibitors reduces post-infarction morbidity and mortality in patients with left ventricular (LV) systolic dysfunction or symptomatic heart failure. Until recently, the effect of such treatment in patients with preserved LV function has not been known. The results from the Heart Outcome Prevention Evaluation trial have indicated that long-term treatment with ramipril leads to a significant reduction in cardiovascular events in patients with atherosclerotic disease, including those with prior myocardial infarction and preserved LV function. These results suggest that long-term angiotensin-converting enzyme inhibition should also be considered in post-infarction patients with normal cardiac function.
Patent AT-E399533-T1: [Translated] COSMETIC COMPOSITION WITH EXTRACTS OF NIGROSPORA SPHAERICA

Disclosed are extracts of Nigrospora sphaerica as cosmetic skin benefit agents, preferably as skin lightening agents alone or in combination with other skin benefit agents and together with a cosmetic vehicle. The inventive extracts, compositions and methods have effective skin lightening properties, may be easier to deliver to the skin, and are commercially available or cost-effective and available in nature.
Cloning and characterization of the mouse

Background
          Mucolipidosis type IV (MLIV) is an autosomal recessive lysosomal storage disorder characterized by severe neurologic and ophthalmologic abnormalities. Recently the MLIV gene, MCOLN1, has been identified as a new member of the transient receptor potential (TRP) cation channel superfamily. Here we report the cloning and characterization of the mouse homologue, Mcoln1, and report a novel splice variant that is not seen in humans.
        
        
          Results
          The human and mouse genes display a high degree of synteny. Mcoln1 shows 91% amino acid and 86% nucleotide identity to MCOLN1. Also, Mcoln1 maps to chromosome 8 and contains an open reading frame of 580 amino acids, with a transcript length of approximately 2 kb encoded by 14 exons, similar to its human counterpart. The transcript that results from murine specific alternative splicing encodes a 611 amino acid protein that differs at the c-terminus.
        
        
          Conclusions
          Mcoln1 is highly similar to MCOLN1, especially in the transmembrane domains and ion pore region. Also, the late endosomal/lysosomal targeting signal is conserved, supporting the hypothesis that the protein is localized to these vesicle membranes. To date, there are very few reports describing species-specific splice variants. While identification of Mcoln1 is crucial to the development of mouse models for MLIV, the fact that there are two transcripts in mice suggests an additional or alternate function of the gene that may complicate phenotypic assessment.
Amitriptyline hydrochloride

Amitriptyline Hydrochloride is a prescription medication available as oral tablets in strengths of 10mg, 25mg, 50mg, 75mg, 100mg, and 150mg. It is a tricyclic antidepressant used to treat conditions like depression. Manufactured by Zydus Pharmaceuticals USA Inc. under ANDA210086. This information was generated using AI and is provided for informational and research purposes only.
Compound 525243: Phthalic acid, propyl nonyl ester

Chemical compound data from PubChem database. IUPAC Name: 2-O-nonyl 1-O-propyl benzene-1,2-dicarboxylate. Molecular Formula: C20H30O4. Molecular Weight: 334.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 525328: 3-Vinyl-1,2-dithiacyclohex-4-ene

Chemical compound data from PubChem database. IUPAC Name: 3-ethenyl-3,6-dihydrodithiine. Molecular Formula: C6H8S2. Molecular Weight: 144.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Activation of tumor necrosis factor receptor 1 in airway smooth muscle: a potential pathway that modulates bronchial hyper-responsiveness in asthma?

The cellular and molecular mechanisms that are involved in airway hyper-responsiveness are unclear. Current studies suggest that tumor necrosis factor (TNF)-α, a cytokine that is produced in considerable quantities in asthmatic airways, may potentially be involved in the development of bronchial hyper-responsiveness by directly altering the contractile properties of the airway smooth muscle (ASM). The underlying mechanisms are not known, but growing evidence now suggests that most of the biologic effects of TNF-α on ASM are mediated by the p55 receptor or tumor necrosis factor receptor (TNFR)1. In addition, activation of TNFR1 coupled to the tumor necrosis factor receptor-associated factor (TRAF)2-nuclear factor-κB (NF-κB) pathway alters calcium homeostasis in ASM, which appears to be a new potential mechanism underlying ASM hyper-responsiveness.
COVID Hospital Data Reporting Guidance Post-PHE

This guidance update reflects changes made to the required data elements for reporting as well as the cadence with which these elements need to be reported to CDC’s National Healthcare Safety Network (NHSN) following the expiration of the federal COVID-19 public health emergency declaration. There are no significant changes or additions to the reporting questions as a result of this guidance update. Information on reporting to NHSN can be found here: <a href='https://www.cdc.gov/nhsn/covid19/hospital-reporting.html'>https://www.cdc.gov/nhsn/covid19/hospital-reporting.html</a>.
Linezolid

Zyvox (linezolid) is an intravenous antibiotic used to treat serious bacterial infections like pneumonia and skin infections. It belongs to the oxazolidinone class and is available in solution form with strengths such as 200 mg/100 mL, 400 mg/200 mL, and 600 mg/300 mL. Manufactured by Pfizer and others, it's a prescription drug. This information was generated using AI and is provided for informational and research purposes only.
Transforming growth factor-β1 blocks the enhancement of tumor necrosis factor cytotoxicity by hyaluronidase Hyal-2 in L929 fibroblasts

Background
          Functional antagonism between transforming growth factor beta (TGF-β) and hyaluronidase has been demonstrated. For example, testicular hyaluronidase PH-20 counteracts TGF-β1-mediated growth inhibition of epithelial cells. PH-20 sensitizes various cancer cells to tumor necrosis factor (TNF) cytotoxicity by upregulating proapoptotic p53 and WW domain-containing oxidoreductase (WOX1). TGF-β1 blocks PH-20-increased TNF cytotoxicity. In the present study, the functional antagonism between TGF-β1 and lysosomal hyaluronidases Hyal-1 and Hyal-2 was examined.
        
        
          Results
          Murine L929 fibroblasts were engineered to stably express green-fluorescent protein (GFP)-tagged hyaluronidase (GFP-Hyal-1 or GFP-Hyal-2) or GFP alone. Compared to control cells, Hyal-2-expressing cells had a significantly increased sensitivity to TNF cytotoxicity (~60–110% increase), while Hyal-1-expressing cells were less sensitive to TNF (~20–90% increase). TNF activated NF-κB, along with IκBα degradation, occurred at 20 to 60 min in Hyal-2 cells post stimulation, but at the 20 min time point in both control and Hyal-1 cells. Hyal-2 cells, but not Hyal-1 and control cells, constitutively expressed WOX1, and transiently expressed Hyal-2 enhanced WOX1-mediated cell death. Unlike PH-20, Hyal-1 and Hyal-2 did not induce p53 expression. Hyal-2 translocated from the lysosome to the mitochondria during staurosporine-mediated apoptosis, suggesting that Hyal-2 may damage mitochondria. Finally, Hyal-1 and Hyal-2 blocked TGF-β1-enhanced L929 cell growth. In contrast, TGF-β1 inhibited Hyal-1- and Hyal-2-increased TNF cytotoxicity in L929 cells by 30–50%.
        
        
          Conclusions
          TGF-β1 limits the ability of Hyal-2 to induce TNF cytotoxicity in L929 cells. Hyal-2-increased TNF cytotoxicity in L929 cells appears to be correlated with upregulation of WOX1, a prolonged NF-κB activation, and Hyal-2 translocation to the mitochondria during apoptosis.
Compound 528610: Cyclopropanecarboxamide, N-n-butyl

Chemical compound data from PubChem database. IUPAC Name: N-butylcyclopropanecarboxamide. Molecular Formula: C8H15NO. Molecular Weight: 141.21. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Number of Diabetes Deaths among Maryland Residents, 1920-2016

This is historical data. The update frequency has been set to "Static Data" and is here for historic value. Updated 8/14/2024. 

Number of deaths among Maryland residents for which diabetes mellitus was the underlying cause of death.  This includes deaths coded to the following International Classification of Diseases codes:
ICD-3 (1920-1929) -- 57
ICD-4 (1930-1938) -- 59
ICD-5 (1939-1948) -- 61
ICD-6 (1949-1957) -- 260
ICD-7 (1958-1967) -- 260
ICD-8 (1968-1978) -- 250
ICD-9 (1979-1998) -- 250
ICD-10 (1999-present) -- E10-E14.
PKQuest: a general physiologically based pharmacokinetic model. Introduction and application to propranolol

Background
          A "physiologically based pharmacokinetic" (PBPK) approach uses a realistic model of the animal to describe the pharmacokinetics. Previous PBPKs have been designed for specific solutes, required specification of a large number of parameters and have not been designed for general use.
        
        
          Methods
          This new PBPK program (PKQuest) includes a "Standardhuman" and "Standardrat" data set so that the user input is minimized. It has a simple user interface, graphical output and many new features: 1) An option that uses the measured plasma concentrations to solve for the time course of the gastrointestinal, intramuscular, intraperotineal or skin absorption and systemic availability of a drug – for a general non-linear system. 2) Capillary permeability limitation defined in terms of the permeability-surface area products. 4) Saturable plasma and tissue protein binding. 5) A lung model that includes perfusion-ventilation mismatch. 6) A general optimization routine using either a global (simulated annealing) or local (Powell) minimization applicable to all model parameters.
        
        
          Results
          PKQuest was applied to measurements of human propranolol pharmacokinetics and intestinal absorption. A meal has two effects: 1) increases portal blood flow by 50%; and 2) decreases liver metabolism by 20%. There is a significant delay in the oval propranolol absorption in fasting subjects that is absent in fed subjects. The oral absorption of the long acting form of propranolol continues for a period of more than 24 hours.
        
        
          Conclusions
          PKQuest provides a new general purpose, easy to use, freely distributed  and physiologically rigorous PBPK software routine.
Compound 526291: 1,4,6,9-Tetrabromo-dibenzofuran

Chemical compound data from PubChem database. IUPAC Name: 1,4,6,9-tetrabromodibenzofuran. Molecular Formula: C12H4Br4O. Molecular Weight: 483.77. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528063: L-Phenylalanine, N-(tert-butyldimethylsilyl)-, tert-butyldimethylsilyl ester

Chemical compound data from PubChem database. IUPAC Name: [tert-butyl(dimethyl)silyl] 2-[[tert-butyl(dimethyl)silyl]amino]-3-phenylpropanoate. Molecular Formula: C21H39NO2Si2. Molecular Weight: 393.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Enteral feeding in the critically ill: comparison between the supine and prone positions: a prospective crossover study in mechanically ventilated patients

Introduction
          Prone position is effective in mechanically ventilated patients to improve oxygenation. It is unknown if prone position affects gastric emptying and the ability of continued enteral feeding.
        
        
          Aim
          To determine tolerance of enteral feeding by measuring gastric residual volumes in enterally fed patients during supine and prone positions.
        
        
          Methods
          Consecutive mechanically ventilated intensive care patients who were turned to prone position were included. All patients were studied for 6 hours in supine position, immediately followed by 6 hours in prone position, or visa versa. The rate of feeding was unchanged during the study period. Gastric residual volume was measured by suctioning the naso-gastric tube after 3 and 6 hours in the same position. Wilcoxon test and regression analysis were used for analysis.
        
        
          Results
          The median volume of administered enteral feeds was 95 ml after 6 hours in supine position and 110 ml after 6 hours in prone position (P = 0.85). In 10 patients, a greater gastric residual volume was found in prone position. In eight others a greater volume was found in supine position. In 18 of 19 patients, gastric residual volumes in both positions were ≥ 150 ml in 6 hours or ≤ 150 ml in 6 hours. Significantly more sedatives were used in prone position. Regression analysis excluded dopamine dose and the starting position as confounders.
        
        
          Conclusion
          Our results suggest that enteral feeding can be continued when a patient is turned from supine to prone position or vice versa. The results indicate that patients with a clinically significant gastric residual volume in one position are likely to have a clinically significant gastric residual volume in the other position.
NSDUH 2021 Pair Level Sampling Weight Report

Learn about the techniques used to create weights for the 2021 National Survey on Drug Use and Health (NSDUH) at the pair and questionnaire dwelling unit (QDU) levels. NSDUH is designed so that some of the sampled households have both an adult and a youth respondent who are paired. Because of this, NSDUH allows for estimating characteristics at the person level, pair level, or QDU level. This report describes pair selection probabilities, the generalized exponential model (including predictor variables used), and the multiple weight components that are used for pair or QDU levels of analysis. An evaluation of the calibration weights is also included.Chapters:Introduces the report.Discusses the probability of selection for pairs and QDUs.Briefly describes of the generalized exponential model.Describes the predictor variables for the model calibration.Defines extreme weights.Discusses weight calibrations.Evaluates the calibration weights.Appendices include technical details about the model and the evaluations that were performed.
NNDSS - Table II. Tetanus to Vibriosis

NNDSS - Table II. Tetanus to Vibriosis - 2016.  In this Table, provisional* cases of selected† notifiable diseases (≥1,000 cases reported during the preceding year), and selected low frequency diseases are displayed. The Table includes total number of cases reported in the United States, by region and by states, in accordance with the current method of displaying MMWR data.  Data on United States exclude counts from US territories.
Note:
These are provisional cases of selected national notifiable diseases, from the National Notifiable Diseases Surveillance System (NNDSS). NNDSS data reported by the 50 states, New York City, the District of Columbia, and the U.S. territories are collated and published weekly as numbered tables printed in the back of the Morbidity and Mortality Weekly Report (MMWR). Cases reported by state health departments to CDC for weekly publication are provisional because of ongoing revision of information and delayed reporting. 

Case counts in this table are presented as they were published in the MMWR issues. Therefore, numbers listed in later MMWR weeks may reflect changes made to these counts as additional information becomes available. 

Footnotes:
C.N.M.I.: Commonwealth of Northern Mariana Islands. 
U: Unavailable.    -: No reported cases.    N: Not reportable.    NN: Not Nationally Notifiable.  NP:  Nationally notifiable but not published.    Cum: Cumulative year-to-date counts.    Med: Median.    Max: Maximum.

* Case counts for reporting year 2016 are provisional and subject to change.  For further information on interpretation of these data, see http://wwwn.cdc.gov/nndss/document/ ProvisionalNationaNotifiableDiseasesSurveillanceData20100927.pdf.  Data for TB are displayed in Table IV, which appears quarterly. 
† Three low incidence conditions, rubella, rubella congenital, and tetanus, have been moved to Table II to facilitate case count verification with reporting jurisdictions. 
§ Any species of the family Vibrionaceae, other than toxigenic Vibrio cholerae O1 or O139.
Patent AT-E400677-T1: [Translated] METHOD AND DEVICE FOR PRODUCING POST-DRAWN CELLULOSE SPINNING YARN

The invention relates to a method and device for producing Lyocell fibres from a spinning solution containing water, cellulose and tertiary amine oxide. The spinning solution is extruded to form spun threads ( 10 ). The spun threads ( 10 ) are stretched and passed through a precipitation bath ( 16 ) in order to precipitate the cellulose. It has been surprisingly revealed that the tenacity of the Lyocell fibres produced in this way can be increased when the stretched fibres are subjected to post-stretching in a post-stretching means. The post-stretched Lyocell fibres have a wet modulus of at least 260 cN/tex.
B lymphocyte involvement in ankylosing spondylitis: the heavy chain 
variable segment gene repertoire of B lymphocytes from germinal center-like 
foci in the synovial membrane indicates antigen selection

The synovial membrane (SM) of affected joints in ankylosing spondylitis (AS) 
is infiltrated by germinal center-like aggregates (foci) of lymphocytes similar 
to rheumatoid arthritis (RA). We characterized the rearranged heavy chain 
variable segment (VH) genes in the SM for gene usage and the mutational pattern 
to elucidate the B lymphocyte involvement in AS.
        Cryosections from an AS-derived SM were stained for B and T lymphocytes. B 
cells were isolated from different areas of a focus. The rearranged VH genes 
were amplified by semi-nested polymerase chain reaction (PCR) using 
oligonucleotides specific for the six different VH families and heavy chain 
joining segments (JHs). PCR products were cloned and sequenced.
        Fifty-nine of 70 different heavy chain gene rearrangements were potentially 
functional. Most of the rearranged genes were mutated (range, 1–15%). Thirty of 
70 products had a mutational pattern typical for antigen selection. Most of the 
rearranged VH genes belonged to the VH3 family (54%), consistent with data from 
healthy donors and patients with RA, while VH4 genes, in contrast to RA, were 
identified less frequently (10%) and VH5 genes were over-represented (11%). In 
contrast to RA, neither VH6 genes nor the autoimmunity-prone VH4-34 were seen, 
whereas another autoimmunity-prone gene, V3-23, was predominantly used (11%). 
One VH1-derived and one VH3-derived B cell clone were expanded. CDR3 were 
shorter and more variable in length than in RA.
        Comparable with RA and reactive arthritis, there is a biased repertoire of 
selected VH genes, whereas the panel of represented genes is different and less 
clonal expansion was observed.
Improvement of Drosophila acetylcholinesterase stability by elimination of a free cysteine

Background
          Acetylcholinesterase is irreversibly inhibited by organophosphate and carbamate insecticides allowing its use for residue detection with biosensors. Drosophila acetylcholinesterase is the most sensitive enzyme known and has been improved by in vitro mutagenesis. However, it is not sufficiently stable for extensive utilization. It is a homodimer in which both subunits contain 8 cysteine residues. Six are involved in conserved intramolecular disulfide bridges and one is involved in an interchain disulfide bridge. The 8th cysteine is not conserved and is present at position 290 as a free thiol pointing toward the center of the protein.
        
        
          Results
          The free cysteine has been mutated to valine and the resulting protein has been assayed for stability using various denaturing agents: temperature, urea, acetonitrile, freezing, proteases and spontaneous-denaturation at room temperature. It was found that the C290V mutation rendered the protein 1.1 to 2.7 fold more stable depending on the denaturing agent.
        
        
          Conclusion
          It seems that stabilization resulting from the cysteine to valine mutation originates from a decrease of thiol-disulfide interchanges and from an increase in the hydrophobicity of the buried side chain.