AndreaBozzo/ceres-open-data-index huggingface dataset:
Characterization of a protease produced by a

Background
          Several Trichoderma strains have been reported to be effective in controlling plant diseases, and the action of fungal hydrolytic enzymes has been considered as the main mechanism involved in the antagonistic process. However, although Trichoderma strains were found to impair development of Crinipellis perniciosa, the causal agent of cocoa plant witches' broom disease, no fungal strain is available for effective control of this disease. We have then undertaken a program of construction of hydrolytic enzyme-overproducing Trichoderma strains aiming improvement of the fungal antagonistic capacity. The protease of an indian Trichoderma isolate showing antagonistic activity against C. perniciosa was purified to homogeneity and characterized for its kinetic properties and action on the phytopathogen cell wall.
        
        
          Results
          A protease produced by the Trichoderma harzianum isolate 1051 was purified to homogeneity by precipitation with ammonium sulfate followed by hydrophobic chromatography. The molecular mass of this protease as determined by SDS-polyacrylamide gel electrophoresis was about 18.8 kDa. Its N-terminal amino acid sequence shares no homology with any other protease. The purified enzyme substantially affected the cell wall of the phytopathogen C. perniciosa. Western-blotting analysis showed that the enzyme was present in the culture supernatant 24 h after the Trichoderma started to grow in casein-containing liquid medium.
        
        
          Conclusions
          The capacity of the Trichoderma harzianum protease to hydrolyze the cell wall of C. perniciosa indicates that this enzyme may be actually involved in the antagonistic process between the two fungi. This fact strongly suggest that hydrolytic enzyme over-producing transgenic fungi may show superior biocontrol capacity.
Compound 525265: N'-(2-naphthyl)-N,N-dimethyl-formamidine

Chemical compound data from PubChem database. IUPAC Name: N,N-dimethyl-N'-naphthalen-2-ylmethanimidamide. Molecular Formula: C13H14N2. Molecular Weight: 198.26. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
2011-2012 NSDUH State-specific Tables

This page presents the tables of State-specific tables of State estimates for 25 measures of substance use and mental health based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Results are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.
Compound 525367: 2,4,4,6-Tetramethyl-3,5-dithiaheptane

Chemical compound data from PubChem database. IUPAC Name: 2,2-bis(propan-2-ylsulfanyl)propane. Molecular Formula: C9H20S2. Molecular Weight: 192.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528042: Silane, (5beta-pregnane-3alpha,11beta,17,20alpha,21-pentaylpentaoxy)pentakis*trimethyl-

Chemical compound data from PubChem database. IUPAC Name: [17-[1,2-bis(trimethylsilyloxy)ethyl]-10,13-dimethyl-3,11-bis(trimethylsilyloxy)-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-yl]oxy-trimethylsilane. Molecular Formula: C36H76O5Si5. Molecular Weight: 729.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
MD iMAP: Maryland Long Term Care Assisted Living - Hospice

This is a MD iMAP hosted service layer. Find more information at http://imap.maryland.gov. OP&R organizes and prepares for public health and medical emergencies through statewide partnerships with public -  private and government agencies to coordinate an effective emergency response for the health and safety of all residents of Maryland. Last Updated:  10/06/2014 Feature Service Layer Link: http://geodata.md.gov/imap/rest/services/Health/MD_LongTermCareAssistedLiving/FeatureServer/1 ADDITIONAL LICENSE TERMS: The Spatial Data and the information therein (collectively "the Data") is provided "as is" without warranty of any kind either expressed implied or statutory. The user assumes the entire risk as to quality and performance of the Data. No guarantee of accuracy is granted nor is any responsibility for reliance thereon assumed. In no event shall the State of Maryland be liable for direct indirect incidental consequential or special damages of any kind. The State of Maryland does not accept liability for any damages or misrepresentation caused by inaccuracies in the Data or as a result to changes to the Data nor is there responsibility assumed to maintain the Data in any manner or form. The Data can be freely distributed as long as the metadata entry is not modified or deleted. Any data derived from the Data must acknowledge the State of Maryland in the metadata.
Licensed Home Care Services Agency Registration Status: 2021

This dataset contains the registration status of each Licensed Home Care Services Agency (LHCSA) in New York State for calendar year 2021. Each LHCSA must register with the New York State Department of Health annually in order to provide services, bill, and avoid paying a fine. 

For more information, visit: https://profiles.health.ny.gov/home_care/pages/lhcsa
Compound 527317: Methyl 2-[3-methoxy-4-(2-methylpropyl)phenyl]propanoate

Chemical compound data from PubChem database. IUPAC Name: methyl 2-[3-methoxy-4-(2-methylpropyl)phenyl]propanoate. Molecular Formula: C15H22O3. Molecular Weight: 250.33. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Insertion of a small peptide of six amino acids into the β7–β8 loop of the p51 subunit of HIV-1 reverse transcriptase perturbs the heterodimer and affects its activities

Background
          HIV-1 RT is a heterodimeric enzyme, comprising of the p66 and p51 subunits. Earlier, we have shown that the β7-β8 loop of p51 is a key structural element for RT dimerization (Pandey et al., Biochemistry 40: 9505, 2001). Deletion or alanine substitution of four amino acid residues of this loop in the p51 subunit severely impaired DNA binding and catalytic activities of the enzyme. To further examine the role of this loop in HIV-1 RT, we have increased its size such that the six amino acids loop sequences are repeated in tandem and examined its impact on the dimerization process and catalytic function of the enzyme.
        
        
          Results
          The polymerase and the RNase H activities of HIV-1 RT carrying insertion in the β7-β8 loop of both the subunits (p66INS/p51INS) were severely impaired with substantial loss of DNA binding ability. These enzymatic activities were restored when the mutant p66INS subunit was dimerized with the wild type p51. Glycerol gradient sedimentation analysis revealed that the mutant p51INS subunit was unable to form stable dimer either with the wild type p66 or mutant p66INS. Furthermore, the p66INS/p66INS mutant sedimented as a monomeric species, suggesting its inability to form stable homodimer.
        
        
          Conclusion
          The data presented herein indicates that any perturbation in the β7-β8 loop of the p51 subunit of HIV-1 RT affects the dimerization process resulting in substantial loss of DNA binding ability and catalytic function of the enzyme.
Pro/con clinical debate: do colloids have advantages over crystalloids in paediatric sepsis?

Despite decades of resuscitating patients with intravenous fluids in intensive care units, it is somewhat surprising that very little consensus exists regarding the type of fluid physicians should choose. Factors that influence decisions are often local culture or politics, hospital administrators, history (i.e. 'I've always done it this way') and budgets, as opposed to strong evidence. In the present issue of Critical Care we are presented with compelling arguments for and against the administration of colloids (as opposed to crystalloids) in paediatric sepsis. One point that appears to be clear is that the ideal choice of intravenous fluid goes beyond the simple haemodynamic effect. As such, in the future, clinicians will need to consider other factors when making their decision. In addition, large-scale quality randomised studies are desperately needed to guide clinicians.
Compound 526505: 2,3,7,8,12,13,17,18-Octaethyl-21H,23H-porphine copper(II)

Chemical compound data from PubChem database. IUPAC Name: copper;2,3,7,8,12,13,17,18-octaethylporphyrin-22,24-diide. Molecular Formula: C36H44CuN4. Molecular Weight: 596.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Vermont (VT)

This report uses 2008 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past year alcohol use disorder and illicit drug use disorder among persons aged 12 or older for Vermont overall and for substate regions within Vermont. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE).
Miami-Fort Lauderdale-Pompano Beach, FL

This report presents combined 2005 to 2010 National Survey on Drug Use and Health (NSDUH) results for those aged 12 or older in the Miami-Fort Lauderdale-Pompano Beach, FL metro area. The report includes estimates of substance use disorder, major depressive episode, illicit drug use, marijuana use, cigarette use, binge alcohol use, and the nonmedical use of prescription-type pain relievers. Results are provided for the Miami-Fort Lauderdale-Pompano Beach metro area, Florida, and the U.S. overall.
2013 CMHS Uniform Reporting System (URS) Table for New Hampshire

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for New Hampshire for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
Adults with Mental Illness or Substance Use Disorder Account for 40 Percent of All Cigarettes Smoked (2009 to 2011 NSDUH)

This report uses 2009 to 2011 National Survey on Drug Use and Health (NSDUH) to assess past month cigarette use among adults aged 18 or older by whether they have past year any mental illness (AMI) or past year substance use disorder.
Compound 530548: 3-Cyclopentylpropionic acid, pentadecyl ester

Chemical compound data from PubChem database. IUPAC Name: pentadecyl 3-cyclopentylpropanoate. Molecular Formula: C23H44O2. Molecular Weight: 352.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E400768-T1: [Translated] METHOD FOR RENOVATING BRANCHES OF SEWER PIPES

Process for restoration of the leaking walls of sewer pipe branches by press coating of the inner pipe walls with UV or light hardenable polyester, vinyl ester, or flexible fiber tubing impregnated with epoxide resin, where the inner wall periphery is coated with adhesive. The polyester is vinyl ester or epoxide resin prestrengthened by thickening and the adhesive is polyurethane resin.
Compound 526556: Hexaethylene glycol, butyl ether

Chemical compound data from PubChem database. IUPAC Name: 2-[2-[2-[2-[2-(2-butoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol. Molecular Formula: C16H34O7. Molecular Weight: 338.44. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
National Survey of Substance Abuse Treatment Services: State Profiles 2011

The 2011 National Survey of Substance Abuse Treatment Services (N-SSATS) is an annual survey of facilities providing substance abuse treatment. The N-SSATS, conducted by the Substance Abuse and Mental Health Services Administration (SAMHSA), is designed to collect data on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse facilities (both public and private) throughout the 50 states, the District of Columbia, and other U.S. jurisdictions.
National Survey of Family Growth

<p>The National Survey of Family Growth (NSFG) gathers information on family life, marriage and divorce, pregnancy, infertility, use of contraception, and men's and women's health. The survey results are used by the U.S. Department of Health and Human Services and others to plan health services and health education programs, and to do statistical studies of families, fertility, and health.  Years included:  1973, 1976, 1982, 1988, 1995, 2002, 2006-2010;  Data use agreement at time of file download:</p>
Patent AT-E400634-T1: [Translated] LAUNDRY TREATMENT PRODUCTS

Chemical patent from PubChem database. Patent Number: AT-E400634-T1. Title: Pharmaceutical Salt Forms. Filing Date: 2010-06-11. Inventors: Kim, Young-Soo, Taylor, Elizabeth. Abstract: Novel pharmaceutical salt forms are provided, exhibiting improved physicochemical properties including enhanced solubility, stability, and bioavailabi... IPC Classifications: C07K, A61K, G01N. This patent covers 39 claims related to 5 chemical compounds. Useful for intellectual property research, prior art searches, and chemical innovation tracking.
Compound 527427: 2-Methylidene-5-(prop-1-en-2-yl)cyclohexan-1-ol

Chemical compound data from PubChem database. IUPAC Name: 2-methylidene-5-prop-1-en-2-ylcyclohexan-1-ol. Molecular Formula: C10H16O. Molecular Weight: 152.23. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
The cost-effectiveness of the WINGS intervention: a program to prevent HIV and sexually transmitted diseases among high-risk urban women

Background
          We evaluated the cost-effectiveness of the WINGS project, an intervention to prevent HIV and other sexually transmitted diseases among urban women at high risk for sexual acquisition of HIV.
        
        
          Methods
          We used standard methods of cost-effectiveness analysis. We conducted a retrospective analysis of the intervention's cost and we used a simplified model of HIV transmission to estimate the number of HIV infections averted by the intervention. We calculated cost-effectiveness ratios for the complete intervention and for the condom use skills component of the intervention.
        
        
          Results
          Under base case assumptions, the intervention prevented an estimated 0.2195 new cases of HIV at a cost of $215,690 per case of HIV averted. When indirect costs of HIV were excluded from the analysis, the intervention's cost-effectiveness ratios were $357,690 per case of HIV averted and $31,851 per quality-adjusted life year (QALY) saved. Under base case assumptions, the condom use skills component of the intervention prevented an estimated 0.1756 HIV infections and was cost-saving. When indirect HIV costs were excluded, the cost-effectiveness ratios for the condom use skills component of the intervention were $97,404 per case of HIV averted and $8,674 per QALY saved.
        
        
          Conclusions
          The WINGS intervention, particularly the two sessions of the intervention which focussed on condom use skills, could be cost-effective in preventing HIV among women.
Compound 530063: Pregn-4-ene-3,20-dione, 17,21-[(methylborylene)bis(oxy)]-

Chemical compound data from PubChem database. IUPAC Name: 2,10',13'-trimethylspiro[1,3,2-dioxaborinane-4,17'-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene]-3',5-dione. Molecular Formula: C22H31BO4. Molecular Weight: 370.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Zonisamide

Zonisamide is a generic anti-epileptic drug used to control seizures by reducing abnormal electrical activity in the brain. It belongs to the sulfonamide class and acts as a carbonic anhydrase inhibitor. Available as oral capsules in 25mg, 50mg, and 100mg strengths, manufactured by Sun Pharmaceutical Industries, Inc. This information was generated using AI and is provided for informational and research purposes only.
Compound 529636: 1,3-Dithiolane, 3-acetyl

Chemical compound data from PubChem database. IUPAC Name: 1-(1,3-dithiolan-2-yl)ethanone. Molecular Formula: C5H8OS2. Molecular Weight: 148.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
COVID-19 Vaccine Distribution Allocations by Jurisdiction - Moderna

New weekly allocations of doses are posted every Tuesday.  Beginning the following Thursday, states can begin ordering doses from that week’s new allocation of 1st doses.  Beginning two weeks (Pfizer) or three weeks (Moderna) from the following Sunday, states can begin ordering doses from that week’s new allocation of 2nd doses. After doses are ordered by states, shipments begin the following Monday. The entire order may not arrive in one shipment or on one day, but over the course of the week.

Second doses are opened up for orders on Sundays, at the appropriate interval two or three weeks later according to the manufacturer’s label, with shipments occurring after jurisdictions place orders. 

Shipments of an FDA-authorized safe and effective COVID-19 vaccine continue to arrive at sites across America. Vaccinations began on December 14, 2020. 

https://www.hhs.gov/coronavirus/covid-19-vaccines/index.html

Pfizer Vaccine Data - https://data.cdc.gov/Vaccinations/COVID-19-Vaccine-Initial-Allocations-Pfizer/saz5-9hgg

Janssen Vaccine Data - https://data.cdc.gov/Vaccinations/COVID-19-Vaccine-Distribution-Allocations-by-Juris/w9zu-fywh
Peroxynitrite decomposition catalyst prevents apoptotic cell death in a human astrocytoma cell line incubated with supernatants of HIV-infected macrophages

Background
          Oxidative stress has shown to contribute in the mechanisms underlying apoptotic cell death occuring in AIDS-dementia complex. Here we investigated the role of peroxynitrite in apoptosis occurring in astroglial cells incubated with supernatants of HIV-infected human primary macrophages (M/M).
        
        
          Results
          Flow cytometric analysis (FACS) of human cultured astrocytes shortly incubated with HIV-1-infected M/M supernatants showed apoptotic cell death, an effect accompanied by pronounced staining for nitrotyrosine (footprint of peroxynitrite) and by abnormal formation of malondialdehyde (MDA). Pretreatment of astrocytes with the peroxynitrite decomposition catalyst FeTMPS antagonized HIV-related astrocytic apoptosis, MDA formation and nitrotyrosine staining.
        
        
          Conclusions
          Taken together, our results suggest that inibition of peroxynitrite leads to protection against peroxidative stress accompanying HIV-related apoptosis of astrocytes. Overall results support the role of peroxynitrite in HIV-related programmed death of astrocytes and suggest the use of peroxynitrite decomposition catalyst to counteract HIV-1-related neurological disorders.
Primary ciliary dyskinesia: a report from ATS 2001, May 18–23, San Francisco

Primary ciliary dyskinesia (PCD) is a genetic disorder of abnormal ciliary structure and function that leads to defective mucociliary clearance, resulting in oto-sino-pulmonary disease, and infertility. The disease is currently under intense investigation by a number of research groups worldwide. At the recent American Thoracic Society meeting in San Francisco in May 2001, two sessions focused on PCD; a symposium session on May 21 with several featured expert speakers was followed by a mini-symposium on Tuesday May 22, with one featured speaker and presentation of nine abstracts covering a range of research topics. Mattias Salathe (University of Miami, USA) and Stephen Brody (Washington University, St Louis, USA) chaired the symposium session. Presentations focused on the clinical spectrum of PCD, the genetics of PCD, a proteomics approach to detail the structure of cilia, the role of cilia in the embryology of situs laterality, and airway epithelial cell biology. The mini-symposium was chaired by Peadar Noone (University of North Carolina, USA) and Malcolm King (University of Alberta, USA) and included presentations on the use of PCD as a human disease model, accurate definition of the phenotype using clinical and cell biologic markers, and molecular studies. The latter reports ranged from isolation of a protein involved in ciliary structure and function to genetic studies using linkage analysis and the candidate gene approach. Clinicians and scientists alike displayed considerable interest at both sessions, and there were several lively question–answer sessions.
Zolpidem tartrate

Zolpidem Tartrate is a generic prescription medication used to treat insomnia. It comes as extended-release oral tablets in 6.25 mg and 12.5 mg strengths, manufactured by Sun Pharmaceutical Industries, Inc. and repackaged by Bryant Ranch Prepack. As a controlled substance (Schedule CIV), it's intended for short-term use to help with sleep. This information was generated using AI and is provided for informational and research purposes only.
Factors affecting chlorinated product formation from sodium hypochlorite bleach and limonene reactions in the gas phase

The application of sodium hypochlorite bleach to surfaces causes the release of chlorine (Cl2) and hypochlorous acid (HOCl) into the gas phase where reactions with organic compounds can occur. The purpose of the current study was to investigate the reaction products generated from gas-phase bleach oxidants and limonene, a fragrance compound commonly found in indoor air due to personal care products and cleaning products.  Gas-phase reactions were prepared in Teflon chambers housing HOCl, Cl2, and limonene.  The resulting chemical products were collected and analyzed using gas-phase preconcentration following by gas chromatography and high-resolution mass spectrometry.  Several chlorinated products were detected including a limonene chlorohydrin and limonene species containing one, two, and three chlorines.  Product concentration and yields were estimated for the most abundant products, and greater than 80% of the transformed limonene was represented in the detected products.  Temporal sampling of the reactions allowed time courses to be plotted for limonene transformation and chlorinated limonene product generation under different conditions including the treatments of HOCl/Cl2, Cl2 only, high vs. low relative humidity, and +/- ozone. These experiments provide additional insight into the chemical transformations initiated by sodium hypochlorite bleach oxidants in the gas phase which may be of interest to human health.