AndreaBozzo/ceres-open-data-index huggingface dataset:
Smoking, season, and detection of

Background
          The prevalence and role of Chlamydia pneumoniae in chronic obstructive pulmonary disease (COPD) remain unclear.
        
        
          Methods
          Peripheral blood mononuclear cells were obtained from 100 outpatients with smoking-related, clinically stable COPD, and induced sputum was obtained in 62 patients.
        
        
          Results
          Patients had mean age (standard deviation) of 65.8 (10.7) years, mean forced expiratory volume in one second of 1.34 (0.61) L, and 61 (61.0%) were male. C. pneumoniae nucleic acids were detected by nested polymerase chain reaction in 27 (27.0%). Current smoking (odds ratio {OR} = 2.6, 95% confidence interval {CI}: 1.1, 6.6, P = 0.04), season (November to April) (OR = 3.6, 95% CI: 1.4, 9.2, P = 0.007), and chronic sputum production (OR = 6.4, 95% CI: 1.8, 23.2, P = 0.005) were associated with detection of C. pneumoniae DNA.
        
        
          Conclusions
          Prospective studies are needed to examine the role of C. pneumoniae nucleic acid detection in COPD disease symptoms and progression.
2014 CMHS Uniform Reporting System (URS) Table for Colorado

2014 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Colorado. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
NNDSS - Table II. Babesiosis to Campylobacteriosis

NNDSS - Table II. Babesiosis to Campylobacteriosis - 2015.In this Table, provisional cases of selected notifiable diseases (≥1,000 cases reported during the preceding year), and selected low frequency diseases are displayed. The Table includes total number of cases reported in the United States, by region and by states, in accordance with the current method of displaying MMWR data.  Data on United States exclude counts from US territories. Note:These are provisional cases of selected national notifiable diseases, from the National Notifiable Diseases Surveillance System (NNDSS). NNDSS data reported by the 50 states, New York City, the District of Columbia, and the U.S. territories are collated and published weekly as numbered tables printed in the back of the Morbidity and Mortality Weekly Report (MMWR). Cases reported by state health departments to CDC for weekly publication are provisional because of ongoing revision of information and delayed reporting. Case counts in this table are presented as they were published in the MMWR issues. Therefore, numbers listed in later MMWR weeks may reflect changes made to these counts as additional information becomes available. Footnotes:C.N.M.I.: Commonwealth of Northern Mariana Islands. U: Unavailable.    -: No reported cases.    N: Not reportable.    NN: Not Nationally Notifiable.    NP: Nationally notifiable but not published.    Cum: Cumulative year-to-date counts.    Med: Median.    Max: Maximum. * Three low incidence conditions, rubella, rubella congenital, and tetanus, have been moved to Table 2 to facilitate case count verification with reporting jurisdictions. ��� Case counts for reporting year 2015 are provisional and subject to change. For further information on interpretation of these data, see http://wwwn.cdc.gov/nndss/document/ProvisionalNationaNotifiableDiseasesSurveillanceData20100927.pdf. Data for TB are displayed in Table IV, which appears quarterly.
2010 State Profile — Virginia

This state profile includes data from facilities in Virginia that reported to N-SSATS for the survey reference date March 31, 2010. Data were collected on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse treatment facilities (both public and private) in Virginia. In Virginia, 208 substance abuse treatment facilities were included in the 2010 N-SSATS, reporting that there were 19,265 clients in substance abuse treatment on March 31, 2010. The survey response rate in Virginia was 89.5%.
Patent AT-E400020-T1: [Translated] TYPE BRIDGES

Methods, systems, and computer program products for converting an object of one type to an object of another type that allow for the runtime operation of the conversion process to be altered or customized. The conversion may occur within an extensible serialization engine that serializes, deserializes, and transforms objects of various types. The runtime operation of the serialization engine is altered by one or more extension routines that implement the desired customizations or extensions, without requiring replacement of other existing routines. Based on type information, identified for an initial object, the object is converted to an intermediate representation which permits runtime modification, including modification of object names, object types, and object data. The intermediate representation of the initial object is modified in accordance with extension routines that alter the runtime operation of the serialization engine, and the intermediate representation is converted to a final object and type.
Compound 526977: (10,13-Dimethyl-3-oxo-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl) dodecanoate

Chemical compound data from PubChem database. IUPAC Name: (10,13-dimethyl-3-oxo-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl) dodecanoate. Molecular Formula: C31H52O3. Molecular Weight: 472.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Four signature motifs define the first class of structurally related large coiled-coil proteins in plants.

Background
          Animal and yeast proteins containing long coiled-coil domains are involved in attaching other proteins to the large, solid-state components of the cell. One subgroup of long coiled-coil proteins are the nuclear lamins, which are involved in attaching chromatin to the nuclear envelope and have recently been implicated in inherited human diseases. In contrast to other eukaryotes, long coiled-coil proteins have been barely investigated in plants.
        
        
          Results
          We have searched the completed Arabidopsis genome and have identified a family of structurally related long coiled-coil proteins. Filament-like plant proteins (FPP) were identified by sequence similarity to a tomato cDNA that encodes a coiled-coil protein which interacts with the nuclear envelope-associated protein, MAF1. The FPP family is defined by four novel unique sequence motifs and by two clusters of long coiled-coil domains separated by a non-coiled-coil linker. All family members are expressed in a variety of Arabidopsis tissues. A homolog sharing the structural features was identified in the monocot rice, indicating conservation among angiosperms.
        
        
          Conclusion
          Except for myosins, this is the first characterization of a family of long coiled-coil proteins in plants. The tomato homolog of the FPP family binds in a yeast two-hybrid assay to a nuclear envelope-associated protein. This might suggest that FPP family members function in nuclear envelope biology. Because the full Arabidopsis genome does not appear to contain genes for lamins, it is of interest to investigate other long coiled-coil proteins, which might functionally replace lamins in the plant kingdom.
Child Care Market Rate Survey Practices and Policies of States, Territories, and Tribes, 2005-2006

The primary objective of this study was to describe current market rate survey methods, practices, and policies in all 50 states, the District of Columbia, five territories, and the 28 Native American tribes that conduct their own market rate survey. A market rate survey is a tool to collect up-to-date information on what facilities, within given geographic areas, charge parents for various types of child care. A second objective was to identify the validity issues that emerge from this comparison of current market rate survey practices.

Variables are organized under six specific functions representing the market rate survey process. These were: (1) administration/organization of the market rate survey, (2) facility population and sample, (3) data collection, (4) data analysis, (5) dissemination of the results, and (6) rate setting policy.

<b>Units of Response: </b>Program

<b>Type of Data: </b>Survey

<b>Tribal Data: </b>Yes

<b>Periodicity: </b>One-time

<b>Demographic Indicators: </b>Geographic Areas;Military

<b>SORN: </b>Not Applicable

<b>Data Use Agreement: </b>Yes

<b>Data Use Agreement Location: </b>https://www.icpsr.umich.edu/rpxlogin

<b>Granularity: </b>Childcare Providers;Individual;State;Tribe

<b>Spatial: </b>United States

<b>Geocoding: </b>Unavailable
Patent AT-E399805-T1: [Translated] METHOD FOR PRODUCING CYLINDRICAL MOLDED BODIES BASED ON CELLULAR POLYURETHANE ELASTOMERS

Preparation of cylindrical molded bodies (I) based on cellular polyurethane elastomers with determined density, tensile strength, elongation and a tear resistance, comprises reaction of prepolymers (i) with cross linking components (ii) in a molded form, where (i) are isocyanate groups based on methylenediphenyldiisocyanate and polyetherdiol; and (ii) contains polyetheralcohol with a nominal functionality of 2-3; diol with a molecular weight of 62-499 g/mol; water; and catalysts. Preparation of cylindrical molded bodies (I) based on cellular polyurethane elastomers with a density of 350-900 kg/m 3> according to DIN EN ISO 1798, a tensile strength of >= 2 N/mm 2> according to DIN EN ISO 1798, elongation of >= 200% according to DIN EN ISO 1798 and a tear resistance of >= 8 N/mm according to DIN ISO 34-1 B, comprises reaction of prepolymers (i) with cross linking components (ii) in a molded form, where (i) are isocyanate groups based on methylenediphenyldiisocyanate and polyetherdiol with a molecular weight of 1500-3000 g/mol based on propylene oxide and/or ethyleneoxide; and (ii) contains polyetheralcohol with a nominal functionality of 2-3 in relation to isocyanates and a molecular weight of 1500-6000 g/mol based on propylene oxide and/or ethyleneoxide; diol with a molecular weight of 62-499 g/mol; water; and catalysts, where (i) and (ii) are filled in a molded form by means of a high pressure machine, which exhibits a mixing head, into which (i) and (ii) are mixed and obtained product amounts to 15-60 g/s.
2015 CMHS Uniform Reporting System (URS) Table for Alaska

2015 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Alaska. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
Patent AT-E400326-T1: [Translated] FACE MASK ARRANGEMENT

A face mask comprises a sealing collar ( 1 ) extending around the mouth with a shelf ( 4 ) extending under the nose supporting a gel insert ( 7 ) that makes sealing contact between the nostrils and a passage ( 6 ) through the shelf. A curved, rigid window ( 30 ) is a push fit in a central opening ( 2 ) of the collar ( 1 ) and has a gas inlet ( 33 ) attached with it so that the window can be removed or connected with the sealing collar as necessary. The collar ( 1 ) supported on the head by a harness ( 20 ) having two triangular portions ( 21 ) on opposite sides encircling respective ears.
Compound 528443: 3,7,11-Trimethyl-1-dodecene

Chemical compound data from PubChem database. IUPAC Name: 3,7,11-trimethyldodec-1-ene. Molecular Formula: C15H30. Molecular Weight: 210.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 527695: Butanoic acid, 4-chloro-, 1,1-dimethylethyl ester

Chemical compound data from PubChem database. IUPAC Name: tert-butyl 4-chlorobutanoate. Molecular Formula: C8H15ClO2. Molecular Weight: 178.65. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Glucocorticoids: do we know how they work?

It is not known to what extent glucocorticoid hormones cause their anti-inflammatory actions and their undesirable side effects by the same or different molecular mechanisms. Glucocorticoids combine with a cytoplasmic receptor that alters gene expression in two ways. One way is dependent on the receptor's binding directly to DNA and acting (positively or negatively) as a transcription factor. The other is dependent on its binding to and interfering with other transcription factors. Both mechanisms could underlie suppression of inflammation. The liganded receptor binds and inhibits the inflammatory transcription factors activator protein-1 and NF-κB. It also directly induces anti-inflammatory genes such as that encoding the protein inhibitor of NF-κB. Recent work has shown that glucocorticoids inhibit signalling in the mitogen-activated protein kinase pathways that mediate the expression of inflammatory genes. This inhibition is dependent on de novo gene expression. It is important to establish the significance of these different mechanisms for the various physiological effects of glucocorticoids, because it may be possible to produce steroid-related drugs that selectively target the inflammatory process.
Community Resiliency Indicator System

The Community Resiliency Indicator System was developed by  San Francisco's Climate and Health Program and is part of San Francisco's Climate and Health Profile. The system includes 40 indicators and an additive index which is a compilation of all of the indicators. See attached methods and project description documents for more details, you can also visit San Francisco's Climate and Health Profile website - www.sfclimatehealth.org (available Feb-2015)
Patent AT-E400909-T1: [Translated] ANTENNA WITH RADIating COAXIAL CABLE

The invention relates to a leaky coaxial antenna (10) comprising an inner conductor (1), a dielectric (2) around the inner conductor (1), and a first shield conductor (4) disposed around the dielectric (2), the first shield conductor having openings (41) distributed in longitudinal direction of the inner conductor (1) and being adapted in that electromagnetic energy passes through the openings (41). A second shield conductor (5) is disposed around or underneath the first shield conductor (4), the second shield conductor (5) being adapted to cover or mask at least a number of the openings (41) of the first shield conductor in a shielded section (S1 - S12). The second shield conductor (5) is arranged discontinuously in the longitudinal direction of the antenna (10) defining uncovered or unmasked portions (AS1 - AS12) of the first shield conductor (4) in the longitudinal direction of the antenna which are adapted in that electromagnetic energy passes through the uncovered portions (AS1 - AS12). Thus, the present invention suggests a two-layer shield for improving the properties of a leaky coaxial antenna with respect to e.g. aerospace applications.
Patent AT-E400340-T1: [Translated] CONVERTIBLE ENTERTAINMENT DEVICE

An apparatus having a support arm, a base coupled to the support arm to maintain the support arm in upright orientation and moveable between a first orientation in which the base is coupleable to a vertical surface, and a second orientation in which the base can rest on a horizontal surface. A light source is coupled to the support arm and a mobile coupled to said support arm, whereby when the base is in the first orientation, the apparatus can be coupled to a crib rail to function as a crib mobile, and when the base is in the second orientation, the apparatus can rest on a horizontal surface to function as a lamp.
Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk

Background
          The Tec family kinases are implicated in signaling from lymphocyte antigen receptors and are activated following phosphorylation by Src kinases. For most Tec kinases, this activation requires an interaction between their pleckstrin homology (PH) domains and the products of phosphoinositide 3-Kinase, which localizes Tec kinases to membrane RAFTs. Rlk/Txk is a Tec related kinase expressed in T cells that lacks a pleckstrin homology domain, having instead a palmitoylated cysteine-string motif. To evaluate Rlk's function in T cell receptor signaling cascades, we examined the requirements for Rlk localization and activation by Src family kinases.
        
        
          Results
          We demonstrate that Rlk is also associated with RAFTs, despite its lack of a pleckstrin homology domain. Rlk RAFT association requires the cysteine-string motif and is independent of PI3 Kinase activity. We further demonstrate that Rlk can be phosphorylated and activated by Src kinases, leading to a decrease in its half-life. A specific tyrosine in the activation loop of Rlk, Y420, is required for phosphorylation and activation, as well as for decreased stability, but is not required for lipid RAFT association. Mutation of this tyrosine also prevents increased tyrosine phosphorylation of Rlk after stimulation of the T cell receptor, suggesting that Rlk is phosphorylated by Src family kinases in response to T cell receptor engagement.
        
        
          Conclusions
          Like the other related Tec kinases, Rlk is associated with lipid RAFTs and can be phosphorylated and activated by Src family kinases, supporting a role for Rlk in signaling downstream of Src kinases in T cell activation.
HIV infection and aging: enhanced Interferon- and Tumor Necrosis Factor-alpha production by the CD8

Background
          T cells from HIV+ and aged individuals show parallels in terms of suppressed proliferative activity and interleukin-2 (I1-2) production and an increased number of CD8+ CD28- T cells. In order to compare cytokine production from T cells from these two states, CD4+ and CD8+ T cells from HIV+ aged, and normal young donors (controls) were monitored for cytokine production by flow cytometry, quantitative PCR and ELISA upon activation by PMA and anti-CD3. In addition, the CD8+ T cell subsets CD28+ and CD28- from the HIV+ and the aged groups were evaluated for cytokine production by flow cytometry, and compared with those from young controls.
        
        
          Results
          Flow cytometric analysis indicated that CD8+ T cells from both HIV+ and aged donors showed an increase of approximately 2–3 fold over controls in percentage of cells producing inflammatory cytokines IFN-γ and TNF-α. Similar analysis also revealed that the production of interleukins-4,6 and 10, production was very low (1–2% of cells) and unchanged in these cells. Quantitative PCR also showed a substantial increase (4–5 fold) in IFN-γ and TNF-α mRNA from HIV+ and aged CD8+ T cells, as did ELISA for secreted IFN-γ and TNF-α (2.3–4 fold). Flow cytometric analysis showed that the CD8+ CD28- T cell subset accounts for approximately 80–86% of the IFN-γ and TNF-α production from the CD8+ subset in the aged and HIV+ states. The CD4+ T cell, while not significantly changed in the HIV+ or aged states in terms of IFN-γ production, showed a small but significant increase in TNF-α production in both states.
        
        
          Conclusions
          Our data appear compatible with physiologic conditions existing in HIV+ and aged individuals, i.e. elevated serum levels and elevated CD8+ T cell production of IFN-γ and TNF-α. Thus, the capacity for increased production of cytokines IFN-γ and TNF-α in the aged individual by the dominant CD8+ CD28- subset may have a profound influence on the clinical state by aggravating inflammatory pathologies such as rheumatoid arthritis, and possibly Alzheimer's disease and Crohn's disease. In AIDS, these cytokines may contribute to wasting and cachexia. We theorize that the predominant phenotypic change to the cytotoxic CD8+ CD28- T cell subsets in both the HIV+ and the aged states may reflect a natural "endpoint" in CD8+ T cell differentiation induced after a lifetime of immune activity (toward viruses, etc) in the aged, and after a massive accelerated response to HIV in the HIV-positive individual.
Gene therapy for established murine collagen-induced arthritis by
		  local and systemic adenovirus-mediated delivery of interleukin-4

To determine whether IL-4 is therapeutic in treating established
			 experimental arthritis, a recombinant adenovirus carrying the gene that encodes
			 murine IL-4 (Ad-mIL-4) was used for periarticular injection into the ankle
			 joints into mice with established collagen-induced arthritis (CIA).
			 Periarticular injection of Ad-mIL-4 resulted in a reduction in the severity of
			 arthritis and joint swelling compared with saline- and adenoviral control
			 groups. Local expression of IL-4 also reduced macroscopic signs of joint
			 inflammation and bone erosion. Moreover, injection of Ad-mIL-4 into the hind
			 ankle joints resulted in a decrease in disease severity in the untreated front
			 paws. Systemic delivery of murine IL-4 by intravenous injection of Ad-mIL-4
			 resulted in a significant reduction in the severity of early-stage
			 arthritis.
Patent AT-E399786-T1: [Translated] 3-SUBSTITUTED 3,4-DIHYDRO-THIENO 2,3-D PYRIMIDINE-4-ONE DERIVATIVES, THEIR PREPARATION AND USE

3-Substituted 3,4-dihydrothieno[2,3-d]pyrimidin-4-one derivatives, production and use thereof. The invention relates to 3,4-dihydrothieno[2,3-d]pyrimidin-4-one derivatives which are substituted in position 3 by 5-membered heteroaryl which may be fused to an aryl or heteroaryl radical, where the heteroaryl and, if appropriate, the fused aryl or heteroaryl radical may have 1, 2 or 3 substituents selected independently of one another from C1-5-alkyl, C1-5-alkoxy, C1-5-alkylthio, halogen, CN, halo-C1-5-alkyl, halo-C1-5-alkoxy, hydroxy, -NH2, -N(R6)2, -NH(R6), aryl, aryloxy, aralkyl, aralkyloxy and heteroaryl, where the substituents aryl, aryloxy, aralkyl, aralkyloxy and heteroaryl may have 1, 2 or 3 substituents selected independently of one another from C1-5-alkyl, C1-5-alkoxy, C1-5-alkylthio, halogen, CN, halo-C1-5-alkyl, halo-C1-5-alkoxy, hydroxy, -NH2, -N(R6)2 and -NH(R6). The preparation and use of these derivatives, especially for therapeutic purposes, e.g. for the treatment of depressions, are likewise described.
Compound 528685: Benzene, 1,3-dimethyl-5-(1-methylpropyl)

Chemical compound data from PubChem database. IUPAC Name: 1-butan-2-yl-3,5-dimethylbenzene. Molecular Formula: C12H18. Molecular Weight: 162.27. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Profile of Adolescent Discharges from Substance Abuse Treatment

This report uses the 2011 Treatment Episode Data Set–Discharges (TEDS-D), a national data system of annual discharges from substance abuse treatment facilities, to create a profile of adolescents who enter treatment for substance abuse.  Specifically, the report examines demographic characteristics of discharges from treatment, treatment setting, health insurance, primary substance of abuse, criminal justice referral, and treatment disposition.