AndreaBozzo/ceres-open-data-index huggingface dataset:
Gastric stimulation: influence of electrical parameters on gastric emptying in control and diabetic rats

Background
          The aim of this study was to test the effect of different pulse frequencies and amplitudes during gastric stimulation (GS) on gastric emptying in the rat.
        
        
          Methods
          GS was performed in 2 groups of laparotomized rats: healthy control animals, and rats with acute diabetes. The effects of four pulse frequencies (0.5, 1, 10, 20 Hz) and three pulse amplitudes (5, 20, 40 mA) were tested. The volumes emptied from the stomach after the oro-gastric instillation of a nutrient solution were compared to those obtained in animals without GS. Intragastric pH values were assessed under basal conditions and after GS.
        
        
          Results
          In both groups, GS increased emptied volumes compared to conditions without stimulation (p < 0.05) for pulse frequencies above 0.5 Hz. Increases in pulse frequencies accelerated gastric emptying (p < 0.01) with a plateau at around 10 Hz. The increase in pulse amplitudes resulted in larger emptied volumes only when the pulse frequency was 1 Hz (p < 0.04) while the opposite effect was observed at 20 Hz (p < 0.04). The most effective combinations to enhance gastric emptying compared to baseline conditions were 10 Hz with 5 or 20 mA. The overall effect of GS on gastric emptying compared to baseline conditions without stimulation, was greater in diabetic than in controls rats (p < 0.05). During stimulation, intragastric pH values were not different from basal conditions during fasting or after a meal in control and diabetic rats.
        
        
          Conclusions
          Although both pulse frequency and amplitude should be considered during GS, frequency appears to be the most critical point. The possibility of increasing gastric emptying by electrical stimulation in diabetic rats suggests potential clinical applications for this method.
Mental Health Annual Report 2015

This report presents results from the Mental Health Client-Level Data (MH-CLD) and Mental Health Treatment Episode Data Set (MH-TEDS) for individuals receiving mental health treatment services in 2015, as well as selected data collection trends for such individuals from 2012 to 2015. The report provides information on mental health diagnoses, mental health treatment services, and demographic and substance use characteristics of individuals in mental health treatment in facilities that reported to individual state administrative data systems.
Patent AT-E400025-T1: [Translated] TRANSLATION SYSTEM AND METHOD FOR WIRELESS DEVICES

The present invention relates to the translation of a portion of text to be communicated in a text-based communication in a communications network. A communications device for composing the text-based communication queries a translation service with a portion of text in a first language to obtain a replacement for the portion in a second language. A user may trigger a replacement query by composing the portion using at least one trigger symbol monitored by the communications device. Replacement may be confirmed with the user and at least one alternative replacement sought in response to the confirmation. The communications network may comprise a wireless network and the communications device a wireless mobile communications device. <IMAGE>
Nationally-normed Well Water Index (WWI)

The WWI is a screening tool that uses nationally available datasets to summarize baseline characteristics about weather-related hazards and vulnerability at the census tract level for communities reliant on private wells. This dataset contains continental US census tracts for which there are nationally-normed WWI assigned. To visualize these data, please visit the Tracking Network at https://ephtracking.cdc.gov/DataExplorer/. For a lay description of these data, please visit https://ephtracking.cdc.gov/indicatorPages and for the scientific publication detailing these data please visit https://pubmed.ncbi.nlm.nih.gov/39510280/

The data for the state-normed WWI can be accessed here
https://data.cdc.gov/dataset/State-Normed-WWI/snkv-n8f6/about_data

The data for census tracts with no Well Water Index (WWI) assigned  can be accessed here https://data.cdc.gov/dataset/No-WWI/agqb-jgkw/about_data
ICU Cornestone: A lecture that changed my practice

In 1982, the author attended a lecture by Professor Joseph Civetta dealing with the concept that, at times, the goal of care should be comfort rather than cure, and that inappropriate care prolonged dying and suffering. Efforts to improve end-of-life care subsequent to this had effects on care at a local level and at a state level. Intensive care providers should be leaders in the provision of appropriate and compassionate care at the end of life.
Patent AT-E400667-T1: [Translated] METHOD FOR PRODUCING AN ABRASION-RESISTANT STEEL SHEET AND STEEL SHEET PRODUCED THEREFORE

Chemical patent from PubChem database. Patent Number: AT-E400667-T1. Title: Crystalline Forms of Chemical Compounds. Filing Date: 1999-05-28. Inventors: Martinez, Carlos, Thompson, Emily. Abstract: The invention provides novel crystalline forms of chemical compounds, characterized by specific X-ray powder diffraction patterns and thermal properti... IPC Classifications: C07H, A61K, A61P. This patent covers 38 claims related to 3 chemical compounds. Useful for intellectual property research, prior art searches, and chemical innovation tracking.
Genomic approaches to research in pulmonary hypertension

Genomics, or the study of genes and their function, is a burgeoning field with many new technologies. In the present review, we explore the application of genomic approaches to the study of pulmonary hypertension (PH). Candidate genes, important to the pathobiology of the disease, have been investigated. Rodent models enable the manipulation of selected genes, either by transgenesis or targeted disruption. Mutational analysis of genes in the transforming growth factor-β family have proven pivotal in both familial and sporadic forms of primary PH. Finally, microarray gene expression analysis is a robust molecular tool to aid in delineating the pathobiology of this disease.
Patent AT-E399763-T1: [Translated] PROTEASE INHIBITORS

A monoacyl semicarbazide of the general formula (I)   nor a pharmaceutically acceptable salt or ester thereof, is capable of selectively inhibiting dipeptidyl-peptidase I (DPP-I), also known as cathepsin C. A compound of the invention is useful as an active substance for the treatment of inflammation, type 2 diabetes, asthma, severe influenza, respiratory syncytial virus infection, CD8 T cell inhibition, inflammatory bowel diseases, psoriasis, atopic dermatitis, Papillon Lefevre syndrome, Haim Munk syndrome, gum disease, periodontitis, rheumatoid arthritis, Huntington's disease, Chagas' disease, Alzheimer's disease, sepsis or for application in target cell apoptosis.
Compound 526156: Dibutyl 3-cyano-phenyl phosphate

Chemical compound data from PubChem database. IUPAC Name: dibutyl (3-cyanophenyl) phosphate. Molecular Formula: C15H22NO4P. Molecular Weight: 311.31. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E400552-T1: [Translated] 4,4'-DITHIOBIS-(3-AMINOBUTANE-1-SULFONATE) DERIVATIVES AND COMPOSITIONS CONTAINING THEM

The invention relates to the bis-hydrochloride of 4,4'-dithiobis-(3-aminobutane-1-sodium sulphonate) and the bis-trifluoracetate of 4,4'-dithiobis-(3-aminobutane-1-sulphonate of 2,2-dimethylpropyl). The invention also relates to a pharmaceutical composition comprising one of said compounds and to the use of one of said compounds for the production of a medicament. The invention is suitable for use in a treatment method for hypertension and indirectly- or directly-linked illnesses.
2011: National Estimates of Drug-Related Emergency Department Visits

This publication presents national estimates of drug-related visits to hospital emergency departments (EDs) for  2011, based on data from the Drug Abuse Warning Network (DAWN). Also presented are comparisons of 2011 estimates with those for 2004, 2009 and 2010.  Chapter topics include overall drug misuse and abuse, illicit drugs, alcohol (drugs and alcohol taken together, underage drinking), nonmedical use of pharmaceuticals, drug-related suicide attempts, seeking detox services, adverse reactions to pharmaceuticals and accidental ingestion of drugs.
Compound 525071: 1,9-Nonanediol, dibutanoate

Chemical compound data from PubChem database. IUPAC Name: 9-butanoyloxynonyl butanoate. Molecular Formula: C17H32O4. Molecular Weight: 300.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Rivastigmine tartrate

Rivastigmine Tartrate is a generic prescription medication, available as oral capsules in strengths of 1.5 mg, 3 mg, 4.5 mg, and 6 mg. Manufactured by Sun Pharmaceutical Industries, Inc., it acts as a cholinesterase inhibitor to help manage symptoms of mild to moderate Alzheimer's disease dementia. This product has been discontinued. This information was generated using AI and is provided for informational and research purposes only.
Compound 530421: Aristolene

Chemical compound data from PubChem database. IUPAC Name: 1,1,7,7a-tetramethyl-2,4,5,6,7,7b-hexahydro-1aH-cyclopropa[a]naphthalene. Molecular Formula: C15H24. Molecular Weight: 204.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Measurement of endotoxin activity in critically ill patients using whole blood neutrophil dependent chemiluminescence

Background
          Lipopolysaccharide (endotoxin) from the cell wall of Gram-negative bacteria is a potent trigger for the release of host-derived inflammatory mediators. The relationship between endotoxaemia, Gram-negative infection and the clinical syndrome of sepsis has been difficult to establish, in part because of the limitations of available endotoxin assays.
        
        
          Methods
          We performed an observational cohort study in critically ill patients in the medical/surgical intensive care unit (ICU) of a tertiary care hospital. Whole blood endotoxin levels on the day of ICU admission were measured using a novel chemiluminescent assay – the endotoxin activity assay (EAA) – and the chromogenic modification of the limulus amoebocyte lysate (LAL) assay.
        
        
          Results
          We studied 74 consecutive admissions. Endotoxin levels were higher in patients with a diagnosis of sepsis (470 ± 57 pg/ml) than in patients admitted with a diagnosis other than sepsis (157 ± 140 pg/ml; P < 0.001). Endotoxaemia was significantly associated with Gram-negative infection (P < 0.05); no patient with a Gram-negative infection had an endotoxin level below 50 pg/ml. White blood cell counts of patients with EAA-detected endotoxaemia were significantly higher (15.7 ± 9.1 × 109 cells/l for endotoxaemic patients versus 10.8 ± 6.2 × 109 cells/l for patients without endotoxaemia; P < 0.05).
        
        
          Conclusion
          Endotoxaemia is associated with Gram-negative infection from any source, and with a diagnosis of sepsis and leukocytosis. These correlations were not apparent using the LAL method. The EAA may be a useful diagnostic tool for the investigation of invasive Gram-negative infection and incipient sepsis.
Publications Using SAMHSA DataNSDUH 2018 Person-Level Sampling Weight Calibration Report

This report contains a brief review of the sampling weight calibration methodology used for the 2018 National Survey on Drug Use and Health (NSDUH). This report also lists detailed documentation on the implementation steps and evaluation results from the weight calibration application. The constrained exponential modeling (CEM) method used in the surveys before 1999 (referred to in this report as the generalized exponential model [GEM]) was modified to provide more flexibility in dealing internally with the extreme weights and for setting bounds directly on the weight adjustment factors so they can become suitable for nonresponse (nr) and poststratification (ps) adjustments.
The society of genes: networks of functional links between genes from comparative genomics

Comparative genomics provides at least three methods for identifying functional links between genes: examination of phylogenetic distributions, analysis of conserved proximity and observations of fusions of genes into a multidomain gene in another organism. We show that the functional networks obtained by applying these methods have different topologies and that the information they provide is largely additive. In particular, the combined networks of functional links contain an average of 57% of an organism's complete genetic complement, uncover substantial portions of known pathways, and suggest the function of previously unannotated genes. In addition, the combined networks are qualitatively different from the networks obtained using individual methods.
Patent AT-E400385-T1: [Translated] METHOD FOR PRODUCING AN OPEN CELL FOAM STRUCTURE

The porous material of the present invention is produced by heating a d ry powder mixture, containing mainly an organic solid binder and inorganic particles. The mixture is foamed while the organic binder is melted. Foaming comes from a foaming agent in the powder mixture. The solid foamed structure comprising inorganic particles embedded in an organic binder is then heated to eliminate the organic binder and finally to sinter the remaining inorganic tri-dimensional network into a rigid structure having interconnected porosity.
Compound 526834: 12-Hydroxy-stearic acid, methyl ester, tBDMS ether

Chemical compound data from PubChem database. IUPAC Name: methyl 12-[tert-butyl(dimethyl)silyl]oxyoctadecanoate. Molecular Formula: C25H52O3Si. Molecular Weight: 428.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 525500: 1-Butanethiol, 4-(methylthio)-

Chemical compound data from PubChem database. IUPAC Name: 4-methylsulfanylbutane-1-thiol. Molecular Formula: C5H12S2. Molecular Weight: 136.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 526494: 5-Chloro-2'-fluoro-2-hydroxyethyaminobenzophenone

Chemical compound data from PubChem database. IUPAC Name: [5-chloro-2-(2-hydroxyethylamino)phenyl]-(2-fluorophenyl)methanone. Molecular Formula: C15H13ClFNO2. Molecular Weight: 293.72. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Surfactant protein-D and pulmonary host defense

Surfactant protein-D (SP-D) participates in the innate response to inhaled microorganisms and organic antigens, and contributes to immune and inflammatory regulation within the lung. SP-D is synthesized and secreted by alveolar and bronchiolar epithelial cells, but is also expressed by epithelial cells lining various exocrine ducts and the mucosa of the gastrointestinal and genitourinary tracts. SP-D, a collagenous calcium-dependent lectin (or collectin), binds to surface glycoconjugates expressed by a wide variety of microorganisms, and to oligosaccharides associated with the surface of various complex organic antigens. SP-D also specifically interacts with glycoconjugates and other molecules expressed on the surface of macrophages, neutrophils, and lymphocytes. In addition, SP-D binds to specific surfactant-associated lipids and can influence the organization of lipid mixtures containing phosphatidylinositol in vitro. Consistent with these diverse in vitro activities is the observation that SP-D-deficient transgenic mice show abnormal accumulations of surfactant lipids, and respond abnormally to challenge with respiratory viruses and bacterial lipopolysaccharides. The phenotype of macrophages isolated from the lungs of SP-D-deficient mice is altered, and there is circumstantial evidence that abnormal oxidant metabolism and/or increased metalloproteinase expression contributes to the development of emphysema. The expression of SP-D is increased in response to many forms of lung injury, and deficient accumulation of appropriately oligomerized SP-D might contribute to the pathogenesis of a variety of human lung diseases.
Storytelling, Social Movements, and the Prevention of Child Abuse and Neglect

Tanzer discusses PCA’s latest work with the FrameWorks Institute and recent research around communications, framing, and messaging. His talk demonstrates how this research can be integrated into prevention professionals' day-to-day work, and how it can drive efforts to build a national movement around the prevention of child abuse and neglect. Additional topics covered are: how revised and reconsidered communications can promote the message of prevention of child abuse and neglect, why the general public has not been as engaged by previous prevention messages, and how professionals in child abuse prevention are changing the way they tell their stories to inspire and motivate the public to take action.

Presenter: Ben Tanzer, Senior Director of Strategic Communications, Prevent Child Abuse America (PCA), a National Prevention Partner

View Webinar (WMV - 68 MB)

Metadata-only record linking to the original dataset. Open original dataset below.
Patent AT-E401463-T1: [Translated] SHOVEL FOR LOADING VEHICLES

The loading bucket [1] used on an earth moving machine is mounted on an articulated arm and can be tipped about an axis for filling. The base is formed with a hopper [2,3] that allows material to enter a rotary screw type feeder [4] for delivery to the left or right hand side of the bucket. This is selectively rotated in either direction by a hydraulic motor [6].
2011 CMHS Uniform Reporting System (URS) Output Tables for Alabama

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2011. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
Compound 527250: 1-Methyl-4-(6-methylhept-4-en-2-yl)benzene

Chemical compound data from PubChem database. IUPAC Name: 1-methyl-4-(6-methylhept-4-en-2-yl)benzene. Molecular Formula: C15H22. Molecular Weight: 202.33. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E400952-T1: [Translated] ßPUSHBACKß METHOD AND DEVICE FOR USE IN MESSAGE TRANSMISSION TO MOBILE TERMINALS

A method for use by a relay network which serves a plurality of host servers, the method comprising the acts of receiving, at the relay network via a public or private network, a message from a host server for delivery to a mobile communication device through a wireless communication network; causing, by the relay network , a result message to be sent to the host server via the public or private network in response to the mobile communication device being unavailable to receive the message through the wireless communication network, the result message comprising a message identifier which uniquely corresponds to the message; receiving, at the relay network via the public or private network, a confirmation message from the host server which indicates that the result message was received by the host server; and clearing the message from memory of the relay network in response to receiving the confirmation message, so as to refrain from maintaining storage of the message in the relay network.
Acyclovir for treating varicella in otherwise healthy children and adolescents: a systematic review of randomised controlled trials

Background
          Acyclovir has the potential to shorten the course of chickenpox which may result in reduced costs and morbidity. We conducted a systematic review of randomised controlled trials that evaluated acyclovir for the treatment of chickenpox in otherwise healthy children.
        
        
          Methods
          MEDLINE, EMBASE, and the Cochrane Library were searched. The reference lists of relevant articles were examined and primary authors and Glaxo Wellcome were contacted to identify additional trials. Two reviewers independently screened studies for inclusion, assessed study quality using the Jadad scale and allocation concealment, and extracted data. Continuous data were converted to a weighted mean difference (WMD). Overall estimates were not calculated due to differences in the age groups studied.
        
        
          Results
          Three studies were included. Methodological quality was 3 (n = 2) and 4 (n = 1) on the Jadad scale. Acyclovir was associated with a significant reduction in the number of days with fever, from -1.0 (95% CI -1.5,-0.5) to -1.3 (95% CI -2.0,-0.6). Results were inconsistent with respect to the number of days to no new lesions, the maximum number of lesions and relief of pruritis. There were no clinically important differences between acyclovir and placebo with respect to complications or adverse effects.
        
        
          Conclusion
          Acyclovir appears to be effective in reducing the number of days with fever among otherwise healthy children with chickenpox. The results were inconsistent with respect to the number of days to no new lesions, the maximum number of lesions and the relief of itchiness. The clinical importance of acyclovir treatment in otherwise healthy children remains controversial.
Compound 526449: Pentafluoropropionic acid, hexyl ester

Chemical compound data from PubChem database. IUPAC Name: hexyl 2,2,3,3,3-pentafluoropropanoate. Molecular Formula: C9H13F5O2. Molecular Weight: 248.19. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E40149-T1: [Translated] PROCESS FOR DESULPHURIZATION OF A SULFUR CONTAINING COMBUSTIBLE GAS.

The invention relates to a process for effecting a high desulphuration of a fuel gas containing sulphur issuing from the gasification of sulphurous fuels, wherein the gas is subjected to the action of vapors of manganese and/or zinc and/or oxides thereof (in the form of aerosols) while it is at a temperature ranging from 1 600 DEG  C. to 350 DEG  C.
Immune Epitope Database and Analysis Resource (IEDB)

<p>This repository contains antibody/B cell and T cell epitope information and epitope prediction and analysis tools for use by the research community worldwide. Immune epitopes are defined as molecular structures recognized by specific antigen receptors of the immune system, namely antibodies, B cell receptors, and T cell receptors. Immune epitopes from infectious diseases, excluding HIV, and immune-mediated diseases and the accompanying biological information are included.</p>