AndreaBozzo/ceres-open-data-index huggingface dataset:
Appetite suppressants and valvular heart disease – a systematic review

Background
          Although appetite suppressants have been implicated in the development of valvular heart disease, the exact level of risk is still uncertain. Initial studies suggested that as many as 1 in 3 exposed patients were affected, but subsequent research has yielded substantially different figures. Our objective was to systematically assess the risk of valvular heart disease with appetite suppressants.
        
        
          Methods
          We accepted studies involving obese patients treated with any of the following appetite suppressants: fenfluramine, dexfenfluramine, and phentermine. Three types of studies were reviewed: controlled and uncontrolled observational studies, and randomized controlled trials. Outcomes of interest were echocardiographically detectable aortic regurgitation of mild or greater severity, or mitral regurgitation of moderate or greater severity.
        
        
          Results
          Of the 1279 patients evaluated in seven uncontrolled cohort studies, 236 (18%) and 60 (5%) were found to have aortic and mitral regurgitation, respectively. Pooled data from six controlled cohort studies yielded, for aortic regurgitation, a relative risk ratio of 2.32 (95% confidence intervals 1.79 to 3.01, p < 0.00001) and an attributable rate of 4.9%, and for mitral regurgitation, a relative risk ratio of 1.55 (95% confidence intervals 1.06 to 2.25, p = 0.02) with an attributable rate of 1.0%. Only one case of valvular heart disease was detected in 57 randomized controlled trials, but this was judged unrelated to drug therapy.
        
        
          Conclusions
          The risk of valvular heart disease is significantly increased by the appetite suppressants reviewed here. Nevertheless, when considering all the evidence, valvulopathy is much less common than suggested by the initial, less methodologically rigorous studies.
Youth Mental Health Tables (Standard Errors and P values) - 2.1 to 2.14

These are the detailed tables pertaining to adult mental health from the 2010 National Survey on Drug Use and Health (NSDUH). These detailed tables present standard errors for totals and prevalence estimates for youths include major depressive episode (MDE), treatment for depression (among youths with MDE), mental health service utilization, and measures related to the co-occurrence of mental disorders with substance use or with substance use disorders. Results are provided for age group, gender, race/ethnicity, education level, government assistance status, poverty level, geographic area, insurance status. Comparisons are made between 2010 and 2002 to 2009.
PCR primers for an aldolase-B intron in acanthopterygian fishes

Background
          Nuclear DNA sequences provide genetic information that complements studies using mitochondrial DNA. Some 'universal' primer sets have been developed that target introns within protein-coding loci, but many simultaneously amplify introns from paralogous loci. Refining existing primer sets to target a single locus could circumvent this problem.
        
        
          Results
          Aldolase intron 'G' was amplified from four fish species using previously described primer sets that target several loci indiscriminately. Phylogenetic analyses were used to group these fragments and other full-length aldolase proteins from teleost fishes into orthologous clades and a primer set was designed to target specifically an intron within the aldolase-B locus in acanthopterygian fishes. DNA amplifications were tried in a variety of acanthopterygian fishes and amplification products, identifiable as aldolase-B intron 'G', were observed in all atherinomorph and percomorph taxa examined. Sequence variation within this locus was found within and among several species examined.
        
        
          Conclusions
          Using 'universal' primer sets coupled with phylogenetic analyses it was possible to develop a genetic assay to target a specific locus in a variety of fish taxa. Sequence variation was observed within and among species suggesting that this targeted assay might facilitate interspecific and intraspecific comparisons.
Clorazepate dipotassium

Clorazepate Dipotassium is a prescription benzodiazepine medication available as oral tablets in strengths of 3.75 mg, 7.5 mg, and 15 mg. It is used to treat anxiety disorders and certain seizure types. Manufactured by ANI Pharmaceuticals, Inc., it is classified as a Schedule CIV controlled substance. This information was generated using AI and is provided for informational and research purposes only.
Differential response to right unilateral ECT in depressed patients: impact of comorbidity and severity of illness [ISRCTN39974945]

Background
          Recent electroconvulsive therapy (ECT) efficacy studies of right unilateral (RUL) ECT may not apply to real life clinics with a wide range of patients with major depressive episodes.
        
        
          Methods
          The study included two groups of patients. In addition to a homogeneous group of patients with major depression according to DSM-IV criteria with severity of the major depressive episode > 16 scores on 17-item Hamilton Rating Scale for Depression (HDRS) (Group 1, n = 16), we included a heterogeneous group of patients with less severe major depressive episodes or with a variety of comorbid conditions (Group 2, n = 24). We randomly assigned the patients to an RUL ECT treatment dosed at 5 or 2.5 times seizure threshold with an intent-to-treat design. The outcomes measured blindly were HDRS, number of treatments, and Mini-Mental State Examination (MMSE). The patients were considered to have responded to treatment if the improvement in HDRS score was at least 60% and they had a total score of less than ten.
        
        
          Results
          The Group 2 patients responded poorer (8% vs. 63%), and had more often simultaneous worsening in their MMSE scores than Group 1 patients. The differences in the outcomes between the two different doses of RUL ECT treatment were not statistically significant.
        
        
          Conclusions
          ECT effectiveness seems to be lower in real-life heterogeneous patient groups than in homogeneous patient samples used in experimental efficacy trials.
2010 CMHS Uniform Reporting System (URS) Output Tables for Arizona

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
Gene expression in epithelial cells in response to pneumovirus infection

Respiratory syncytial virus (RSV) and pneumonia virus of mice (PVM) are viruses of the family Paramyxoviridae, subfamily pneumovirus, which cause clinically important respiratory infections in humans and rodents, respectively. The respiratory epithelial target cells respond to viral infection with specific alterations in gene expression, including production of chemoattractant cytokines, adhesion molecules, elements that are related to the apoptosis response, and others that remain incompletely understood. Here we review our current understanding of these mucosal responses and discuss several genomic approaches, including differential display reverse transcription-polymerase chain reaction (PCR) and gene array strategies, that will permit us to unravel the nature of these responses in a more complete and systematic manner.
Aminoglycoside antibiotics and autism: a speculative hypothesis

Background
          Recently, it has been suspected that there is a relationship between therapy with some antibiotics and the onset of autism; but even more curious, some children benefited transiently from a subsequent treatment with a different antibiotic. Here, we speculate how aminoglycoside antibiotics might be associated with autism.
        
        
          Presentation
          We hypothesize that aminoglycoside antibiotics could a) trigger the autism syndrome in susceptible infants by causing the stop codon readthrough, i.e., a misreading of the genetic code of a hypothetical critical gene, and/or b) improve autism symptoms by correcting the premature stop codon mutation in a hypothetical polymorphic gene linked to autism.
        
        
          Testing
          Investigate, retrospectively, whether a link exists between aminoglycoside use (which is not extensive in children) and the onset of autism symptoms (hypothesis "a"), or between amino glycoside use and improvement of these symptoms (hypothesis "b"). Whereas a prospective study to test hypothesis "a" is not ethically justifiable, a study could be designed to test hypothesis "b".
        
        
          Implications
          It should be stressed that at this stage no direct evidence supports our speculative hypothesis and that its main purpose is to initiate development of new ideas that, eventually, would improve our understanding of the pathobiology of autism.
Treatment Episode Data Set: Admissions (TEDS-A-1993)

<p>The Treatment Episode Data Set -- Admissions (TEDS-A) is a national census data system of annual admissions to substance abuse treatment facilities. TEDS-A provides annual data on the number and characteristics of persons admitted to public and private substance abuse treatment programs that receive public funding. The unit of analysis is a treatment admission. TEDS consists of data reported to state substance abuse agencies by the treatment programs, which in turn report it to SAMHSA.<br />
A sister data system, called the Treatment Episode Data Set -- Discharges (TEDS-D), collects data on discharges from substance abuse treatment facilities. The first year of TEDS-A data is 1992, while the first year of TEDS-D is 2006.<br />
TEDS variables that are required to be reported are called the "Minimum Data Set (MDS)", while those that are optional are called the "Supplemental Data Set (SuDS)".<br />
Variables in the MDS include: information on service setting, number of prior treatments, primary source of referral, sex, race, ethnicity, education, employment status, substance(s) abused, route of administration, frequency of use, age at first use, and whether methadone was prescribed in treatment. Supplemental variables include: diagnosis codes, presence of psychiatric problems, living arrangements, source of income, health insurance, expected source of payment, pregnancy and veteran status, marital status, detailed not in labor force codes, detailed criminal justice referral codes, days waiting to enter treatment, and the number of arrests in the 30 days prior to admissions (starting in 2008).<br />
Substances abused include alcohol, cocaine and crack, marijuana and hashish, heroin, nonprescription methadone, other opiates and synthetics, PCP, other hallucinogens, methamphetamine, other amphetamines, other stimulants, benzodiazepines, other non-benzodiazepine tranquilizers, barbiturates, other non-barbiturate sedatives or hypnotics, inhalants, over-the-counter medications, and other substances.<br />
Created variables include total number of substances reported, intravenous drug use (IDU), and flags for any mention of specific substances. This study has 1 Data Set.</p>
Compound 529117: 4-Quinazolone, 3-butyl-2-methyl

Chemical compound data from PubChem database. IUPAC Name: 3-butyl-2-methylquinazolin-4-one. Molecular Formula: C13H16N2O. Molecular Weight: 216.28. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528172: 1,3-Cyclopentadiene, 2-(1-methylethyl)

Chemical compound data from PubChem database. IUPAC Name: 2-propan-2-ylcyclopenta-1,3-diene. Molecular Formula: C8H12. Molecular Weight: 108.18. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Wastewater Treatment Plants

<div>[<a href='https://files.hawaii.gov/dbedt/op/gis/data/WWTP.pdf' target='_blank' rel='nofollow ugc noopener noreferrer'>Metadata</a>] Inventory and location of public and private wastewater treatment plants (WWTP) in the State of Hawaii.  Hawaii Administrative Rules, Chapter 11-62 outlines the rules that govern these wastewater systems in the state of Hawaii.  Data is current as of January, 2023 and is provided as a courtesy to government agencies and the public.  Data updates will be provided as time and staffing permits; no assurances are made that data will be maintained or updated on a regular basis.  <br /></div><div><br /></div><div>For more information, please refer to metadata at <a href='https://files.hawaii.gov/dbedt/op/gis/data/WWTP.pdf' target='_blank' rel='nofollow ugc noopener noreferrer'>https://files.hawaii.gov/dbedt/op/gis/data/WWTP.pdf</a> or contact Hawaii Statewide GIS Program, Office of Planning and Sustainable Development, State of Hawaii; PO Box 2359, Honolulu, Hi. 96804; (808) 587-2846; email: gis@hawaii.gov; Website: <a href='https://planning.hawaii.gov/gi' target='_blank' rel='nofollow ugc noopener noreferrer'>https://planning.hawaii.gov/gi</a>s.</div>
Trends in Heroin Use in the United States: 2002 to 2013

This short report uses 2002 to 2013 National Survey on Drug Use and Health (NSDUH) to assess heroin-related trends in the United States among those aged 12 or older.  Topics covered include past year heroin use, dependence and abuse, receipt of substance use treatment for herion use, heroin initiation, perceived risk from using heroin, and the perceived availability of heroin.  Results are shown for those aged 12 or older and for three age groups within this population: adolescents aged 12 to 17, young adults aged 18 to 25, and 26 or older.
Compound 528085: Ethyl 2-chlorophenylcarbamate

Chemical compound data from PubChem database. IUPAC Name: ethyl N-(2-chlorophenyl)carbamate. Molecular Formula: C9H10ClNO2. Molecular Weight: 199.63. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E399748-T1: [Translated] LIQUIDS WITH PARTIALLY HYDROGENATED SUBSTITUTED LINEAR STYRENE DIMERS AND PRODUCTION METHODS

A basestock that comprises a fully hydrogenated substituted styrene linear dimer; a partially hydrogenated mono-aromatic substituted styrene linear dimer; and a partially hydrogenated di-aromatic substituted styrene linear dimer. A process of producing a basestock that comprises reacting a feed stream that comprises substituted styrene, alcohol, and a dimerization catalyst, in the presence of a solvent, to form a crude slurry of dimerized substituted styrene; and partially hydrogenating the dimerized substituted styrene with hydrogen over a Group VIII catalyst to form a basestock that comprises a fully hydrogenated substituted styrene linear dimer and a partially hydrogenated substituted styrene linear dimer.
Compound 525712: N-(4-Methylbenzylidene)-3-chloroaniline

Chemical compound data from PubChem database. IUPAC Name: N-(3-chlorophenyl)-1-(4-methylphenyl)methanimine. Molecular Formula: C14H12ClN. Molecular Weight: 229.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Prescription Drug Use and Misuse in the United States: Results from the 2015 National Survey on Drug Use and Health

This report presents findings from the 2015 National Survey on Drug Use and Health (NSDUH) on the use and misuse of prescription psychotherapeutic drugs (i.e., pain relievers, tranquilizers, stimulants, and sedatives) in the past year for the population aged 12 or older in the United States. The report presents additional findings that are relevant to the misuse of prescription drugs, such as motivations for misuse and where individuals obtained the last prescription drugs that they misused. The report also will discuss the redesign of the prescription drug questions for 2015, the new definition for misuse, and relevant terminology issues (e.g., \"misuse\" rather than \"nonmedical use\"). Estimates for selected outcomes are presented by age, gender, race, Hispanic origin, and county type.
Compound 527700: 1-Methylethyl 4-chlorobutanoate

Chemical compound data from PubChem database. IUPAC Name: propan-2-yl 4-chlorobutanoate. Molecular Formula: C7H13ClO2. Molecular Weight: 164.63. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 525607: N,N-Dimethyl-N'-(4-nitrophenyl)-p-chlorobenzamidine

Chemical compound data from PubChem database. IUPAC Name: 4-chloro-N,N-dimethyl-N'-(4-nitrophenyl)benzenecarboximidamide. Molecular Formula: C15H14ClN3O2. Molecular Weight: 303.74. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
The role of collagenase in emphysema

The extracellular matrix is essential for the integrity of the lung and when disrupted can lead to the architectural changes seen in emphysema. The etiology of emphysema is believed to be due to an imbalance in the proteases and antiproteases within the lung. Studies have focused on elastolytic enzymes as the primary agents in disease pathogenesis, however, recent data suggest that collagenases may also be involved in the destruction of lung tissue in emphysema. It is hoped that this expanded understanding of the pathophysiology of emphysema will lead to improved therapy in the treatment of the disease.
Patent AT-E399909-T1: [Translated] QUICK CONNECTOR FOR REINFORCEMENT IRONS TO SOCKET DOWELS

A quick-connector for terminal fastening of a penetrating rebar (7) to a perpendicularly oriented concrete dowel (2), the connector comprising a wire clip (1) having a deflected segment of wire of the length (L) at least partially made of resilient-elastic metal, wherein the wire clip (1) includes, with respect to a primary turning arc (3), arms (5, 5') that are mirror-symmetrical to an angle-bisecting plane (4), wherein each arm (5, 5') forms a deflected secondary turning arc (6, 6') transverse to the primary turning arc (3) and a clippable hook (8, 8') that rests force-lockingly into a radial external surface zone (9), of a terminal radial expansion (1), of the concrete dowel (2).
Patent AT-E401784-T1: [Translated] SELECTION SYSTEM AND METHOD FOR MILKING ANIMALS

A selection system for animals comprising: (a) a milking area ( 20 ) arranged to enable milking of one or more lactating animals (b) a drinking station ( 30 ) remote from the milking area ( 20 ) in which is positioned an attractant configured to attract an animal from a grazing paddock ( 50 ) (c) an entry race ( 70 ) connecting the drinking station ( 30 ) and the milking area ( 20 ) (d) a control mechanism ( 60 ) configured to permit entry of a lactating animal meeting a predefined criterion into the entry race ( 70 ) from the drinking station ( 30 ). Also a method utilising the above system and comprising: (a) attracting an animal from a grazing paddock ( 50 ) into the drinking station ( 30 ) remote from the milking area ( 20 ) (b) determining whether the animal in the drinking station ( 30 ) meets a predefined criterion (c) permitting entry of the animal meeting the predefined criterion into the entry race ( 70 ).
Patent AT-E400276-T1: [Translated] NON-NUCLEOSIDIC REVERSE TRANSCRIPTASE INHIBITORS AS ANTAGONISTS OF CELL PROLIFERATION AND INDUCTORS OF CELL DIFFERENTIATION

Chemical patent from PubChem database. Patent Number: AT-E400276-T1. Title: Novel Pharmaceutical Composition. Filing Date: 1998-02-08. Inventors: Anderson, Robert, Davis, Linda. Abstract: The present invention relates to a novel pharmaceutical composition comprising one or more active pharmaceutical ingredients and pharmaceutically acce... IPC Classifications: C07D, A61K, A61P. This patent covers 32 claims related to 8 chemical compounds. Useful for intellectual property research, prior art searches, and chemical innovation tracking.
A novel tetratricopeptide repeat (TPR) containing PP5 serine/threonine protein phosphatase in the malaria parasite,

Background
          The malarial parasite, Plasmodium falciparum (Pf), is responsible for nearly 2 million deaths worldwide. However, the mechanisms of cellular signaling in the parasite remain largely unknown. Recent discovery of a few protein kinases and phosphatases point to a thriving reversible phosphorylation system in the parasite, although their function and regulation need to be determined.
        
        
          Results
          We provide biochemical and sequence evidence for a protein serine/threonine phosphatase type PP5 in Plasmodium falciparum, and named it PfPP5. The 594-amino acid polypeptide was encoded by a 1785 nucleotide long intronless gene in the parasite. The recombinant protein, expressed in bacteria, was indistinguishable from native PfPP5. Sequencing comparison indicated that the extra-long N-terminus of PfPP5 outside the catalytic core contained four tetratricopeptide repeats (TPRs), compared to three such repeats in other PP5 phosphatases. The PfPP5 N-terminus was required for stimulation of the phosphatase activity by polyunsaturated fatty acids. Co-immunoprecipitation demonstrated an interaction between native PfPP5 and Pf heat shock protein 90 (hsp90). PfPP5 was expressed in all the asexual erythrocytic stages of the parasite, and was moderately sensitive to okadaic acid.
        
        
          Conclusions
          This is the first example of a TPR-domain protein in the Apicomplexa family of parasites. Since TPR domains play important roles in protein-protein interaction, especially relevant to the regulation of PP5 phosphatases, PfPP5 is destined to have a definitive role in parasitic growth and signaling pathways. This is exemplified by the interaction between PfPP5 and the cognate chaperone hsp90.
A Day in the Life of American Adolescents: Substance Use Facts Update

This short report uses data from the 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs), the 2010 Treatment Episode Data Set (TEDS), the 2010 National Survey of Substance Abuse Treatment Services (N-SSATS), and the 2011 Drug Abuse Warning Network (DAWN) to present facts about adolescent substance use, including information on the initiation of substance use, past year substance use, emergency department visits, and receipt of substance use treatment.
Patent AT-E400494-T1: [Translated] METHOD OF OBTAINING A BOX FRAME FOR CONSTRUCTION AND RESULTING BOX FRAME

A process for the production of a frame for a construction adapted to float includes the steps consisting in: forming a flotation element (12) whose upper portion includes a network of grooves adapted to form formwork for beams (14) of concrete as well as wells, passing through the flotation element (12), adapted to form formwork for concrete columns (16); preferably, arranging reinforcing iron in the formworks and adding at the periphery a formwork to form a belt; and pouring the concrete.
Patent AT-E400597-T1: [Translated] POLYETHERURETHANE RESISTANT ELASTOMERS AND THIN-WALLED OBJECTS MADE THEREFROM

The present invention provides polyetherurethaneurea (PEUU) elastomers having an excellent combination of elastic properties including low modulus, high elongation, high tensile strength and a high degree of retained stress. Thin-walled films made from these elastomers may be fashioned into items such as medical gloves, scientific gloves, condoms, etc.