AndreaBozzo/ceres-open-data-index huggingface dataset:
Compound 530091: 2-Methyladenine, TMS

Chemical compound data from PubChem database. IUPAC Name: N,7-bis(trimethylsilyl)-2-trimethylsilyloxypurin-6-amine. Molecular Formula: C14H29N5OSi3. Molecular Weight: 367.67. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528876: Phe,TFE-PFP

Chemical compound data from PubChem database. IUPAC Name: 2,2,2-trifluoroethyl 2-(2,2,3,3,3-pentafluoropropanoylamino)-3-phenylpropanoate. Molecular Formula: C14H11F8NO3. Molecular Weight: 393.23. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Ketorolac tromethamine

Ketorolac Tromethamine is an injectable non-steroidal anti-inflammatory drug (NSAID) that helps relieve moderate to severe pain. Available in 15 mg/mL and 30 mg/mL strengths, it's given via intramuscular or intravenous injection. Manufactured by Fresenius Kabi USA, LLC, under application ANDA203242. This information was generated using AI and is provided for informational and research purposes only.
Patent AT-E400251-T1: [Translated] COMPOSITIONS OF BASIC DRUGS WITH IMPROVED BIOAVAILABILITY

A composition comprising a basic drug, a drug which forms a zwitterion, or a salt of either entity, admixed with a polymer selected from hydroxypropylmethylcellulose acetate succinate (HPMCAS), cellulose acetate trimellitate (CAT), cellulose acetate phthalate (CAP), hydroxypropylcellulose acetate phthalate (HPCAP), hydroxypropylmethyl-cellulose acetate phthalate (HPMCAP), and methylcellulose acetate phthalate (MCAP). The compositions having improved solubility, hence bioavailability, in the small intestine; Processes for testing such compositions, and methods of using such compositions. The compositions comprise the basic drug, zwitterion, or salt and one or more of the aforementioned polymers. The invention further relates to a method for increasing the bioavailability of a basic or a zwitterionic drug comprising co-administering the basic drug, the zwitterionic drug, or the salt, with one or more of the aforementioned polymers.
The genetics of chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is a significant cause of global morbidity and mortality. Previous studies have shown that COPD aggregates in families, suggesting a genetic predisposition to airflow obstruction. Many candidate genes have been assessed, but the data are often conflicting. We review the genetic factors that predispose smokers to COPD and highlight the future role of genomic scans in identifying novel susceptibility genes.
Patent AT-E401063-T1: [Translated] ADMINISTRATION OF ANTHISTAMINICS BY INHALATION

The present invention relates to the delivery of antipsychotics through an inhalation route. Specifically, it relates to aerosols containing antipsychotics that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of an antipsychotic. In a method aspect of the present invention, an antipsychotic is delivered to a mammal through an inhalation route. The method comprises: a) Heating a composition, wherein the composition comprises at least 5 percent by weight of an antipsychotic, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering an antipsychotic through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of an antipsychotic; and, b) a device that forms an antipsychotic containing aerosol from the composition, for inhalation by the mammal.
National Post-acute and Long-term Care Study: Residential Care Community Restricted Dataset

The National Post-acute and Long-term Care Study (NPALS) is a biennial study of major post-acute and long-term care providers and their services users. Seven provider settings are included. NPALS collects survey data on the residential care community and adult day services sectors, and uses administrative data (available from CMS) for home health, nursing home, hospice, inpatient rehabilitation, and long-term care hospital sectors.
The goals of the study are to: estimate the supply of paid, regulated post-acute and long-term care services providers; estimate key policy-relevant characteristics and practices of these providers; estimate the number of post-acute and long-term care services users; estimate key policy-relevant characteristics of these users; produce national and state estimates where feasible; compare across provider sectors; and monitor trends over time.
Table 6. 2011-2012 NSDUH Illicit Drug Use Other Than Marijuana in the Past Month, by Age Group and State

Table 6. Illicit Drug Use Other Than Marijuana in the Past Month, by Age Group and State: Percentages, Annual Averages Based on 2011 and 2012 NSDUHs. Results are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.
Compound 528992: Heptacosane, 1,2-bis(methylthio)

Chemical compound data from PubChem database. IUPAC Name: 1,2-bis(methylsulfanyl)heptacosane. Molecular Formula: C29H60S2. Molecular Weight: 472.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E400356-T1: [Translated] KNEADING AND GRANULATING MACHINE

A kneading and granulating machine comprises: a container containing a material to be kneaded; a kneading member, which moves along the inner wall surface of the container and revolves and spins at the same time within the container; and a crushing blade, which revolves and spins at the same time within the container to shear the material to be kneaded in the container. The kneading member comprises a blade having a shape corresponding to the inner wall surface of the container, which enables kneading the material to be kneaded between itself and the inner wall surface of the container.
NanoSpotTM Collector for Aerosol Sample Collection for Direct Microscopy and Spectroscopy Analysis-Dataset

We describe design and characterization of an aerosol NanoSpotTM collector, designed for collection of airborne particles on a microscopy substrate for direct electron microscopy, optical microscopy, and laser spectroscopy analysis. The collector implements a water-based, laminar-flow, condensation growth technique, followed by impaction onto an optical/electron microscopy substrate or a transmission electron microscopy grid for direct analysis. The compact design employs three parallel growth tubes allowing a sampling flow rate of 1.2 L min-1. Each of the three growth tubes consists of three-temperature regions, for controlling the water vapor saturation profile and exit dew point. Following the droplet growth, the three streams merge into one flow and a converging nozzle enhances focusing of the grown droplets into a tight beam, prior to their final impaction on the warm surface of the collection substrate. A miniscule sample deposition area is attained for effective coupling with microscopic and spectroscopic analysis. Experiments were conducted for the acquisition of the size-dependent collection efficiency, the uniformity of the spot deposit, the surface density distribution of the collected particles, and the aerosol concentration effect on the triple-tube NanoSpotTM Collector. Particles as small as 7 nm could be activated and collected on the electron microscopy stub. A spot deposit of approximately 0.7-mm diameter is formed for particles over a broad particle diameter range. The collected particle samples were analyzed using electron microscopy and Raman spectroscopy for the acquisition of the particle spatial distribution, the spot sample uniformity, and the analyte concentration. Finally, the NanoSpotTM collector’s analytical measurement sensitivity for laser Raman analysis and the counting statistics for fiber count measurement using optical microscopy were calculated and were compared with those of the conventional aerosol sampling methods.
Selection in the evolution of gene duplications

Background
          Gene duplications have a major role in the evolution of new biological functions. Theoretical studies often assume that a duplication per se is selectively neutral and that, following a duplication, one of the gene copies is freed from purifying (stabilizing) selection, which creates the potential for evolution of a new function.
        
        
          Results
          In search of systematic evidence of accelerated evolution after duplication, we used data from 26 bacterial, six archaeal, and seven eukaryotic genomes to compare the mode and strength of selection acting on recently duplicated genes (paralogs) and on similarly diverged, unduplicated orthologous genes in different species. We find that the ratio of nonsynonymous to synonymous substitutions (Kn/Ks) in most paralogous pairs is <<1 and that paralogs typically evolve at similar rates, without significant asymmetry, indicating that both paralogs produced by a duplication are subject to purifying selection. This selection is, however, substantially weaker than the purifying selection affecting unduplicated orthologs that have diverged to the same extent as the analyzed paralogs. Most of the recently duplicated genes appear to be involved in various forms of environmental response; in particular, many of them encode membrane and secreted proteins.
        
        
          Conclusions
          The results of this analysis indicate that recently duplicated paralogs evolve faster than orthologs with the same level of divergence and similar functions, but apparently do not experience a phase of neutral evolution. We hypothesize that gene duplications that persist in an evolving lineage are beneficial from the time of their origin, due primarily to a protein dosage effect in response to variable environmental conditions; duplications are likely to give rise to new functions at a later phase of their evolution once a higher level of divergence is reached.
SHIP Emergency Department Visit Rate Due To Diabetes 2008-2017

This is historical data. The update frequency has been set to "Static Data" and is here for historic value. Updated on 8/14/2024

Emergency Department Visit Rate Due To Diabetes - This indicator shows the emergency department visit rate due to diabetes (per 100,000 population). Diabetes can lead to blindness, heart, and blood vessel disease, stroke, kidney failure, amputations, nerve damage, pregnancy complications, and birth defects. Emergency department visits for diabetes-related complications may signify that the disease is uncontrolled. In Maryland, there were 12,907 emergency department visits for primary diagnosis of diabetes in 2014.
A rapid method to map mutations in

Background
          Genetic screens in Drosophila have provided a wealth of information about a variety of cellular and developmental processes. It is now possible to screen for mutant phenotypes in virtually any cell at any stage of development by performing clonal screens using the flp/FRT system. The rate-limiting step in the analysis of these mutants is often the identification of the mutated gene, however, because traditional mapping strategies rely mainly on genetic and cytological markers that are not easily linked to the molecular map.
        
        
          Results
          Here we describe the development of a single-nucleotide polymorphism (SNP) map for chromosome arm 3R. The map contains 73 polymorphisms between the standard FRT chromosome, and a mapping chromosome that carries several visible markers (rucuca), at an average density of one SNP per 370 kilobases (kb). Using this collection, we show that mutants can be mapped to a 400 kb interval in a single meiotic mapping cross, with only a few hundred SNP detection reactions. Discovery of further SNPs in the region of interest allows the mutation to be mapped with the same recombinants to a region of about 50 kb.
        
        
          Conclusion
          The combined use of standard visible markers and molecular polymorphisms in a single mapping strategy greatly reduces both the time and cost of mapping mutations, because it requires at least four times fewer SNP detection reactions than a standard approach. The use of this map, or others developed along the same lines, will greatly facilitate the identification of the molecular lesions in mutants from clonal screens.
Compound 526695: 2-O-acetyl-1,5-anhydro-3,4-di-O-methyl-D-fucitol

Chemical compound data from PubChem database. IUPAC Name: (4,5-dimethoxy-6-methyloxan-3-yl) acetate. Molecular Formula: C10H18O5. Molecular Weight: 218.25. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
2010 CMHS Uniform Reporting System (URS) Output Tables for Colorado

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
Compound 529889: Trimethylsilyl hexadec-9-enoate

Chemical compound data from PubChem database. IUPAC Name: trimethylsilyl hexadec-9-enoate. Molecular Formula: C19H38O2Si. Molecular Weight: 326.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 525465: 2-(Tert-butylsulfanyl)ethane-1-thiol

Chemical compound data from PubChem database. IUPAC Name: 2-tert-butylsulfanylethanethiol. Molecular Formula: C6H14S2. Molecular Weight: 150.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E400442-T1: [Translated] INK JET MEDIA WITH MULTIPLE COATING LAYERS OF POROUS MEDIA

The present invention is drawn to a print medium and a method of preparing the same. The print medium can include a media substrate, a porous ink-absorbing layer coated on the media substrate, and a porous ink-receiving layer coated on the porous ink-absorbing layer. The porous ink-absorbing layer can include semi-metal oxide or metal oxide particulates and a first binder, and the porous ink-receiving layer can include organosilane-functionalized semi-metal oxide or metal oxide particulates and a second binder.
Patent AT-E401717-T1: [Translated] PERFORMANCE EFFICIENT CHANNEL ALLOCATION PLANNING IN A WIRELESS NETWORK

A method and system for optimizing channel access scheduling for multiple wireless computing devices over a wireless network improves channel access efficiency with respect to a primary channel. An access point, or host computer, includes a host transceiver for receiving control information from the wireless computing devices over a low power channel. Upon receiving the control information, the access point applies a scheduling algorithm to schedule channel access for the wireless computing devices to transmit data over the primary communication channel. The wireless computing devices include a low power radio for receiving scheduling information via the low power channel during idle periods. When the scheduling information is received, the wireless computing device activates its primary channel network interface components to communicate data through the primary channel. When the computing device is idle, the device is configured to power down all of its components with the exception of the circuitry required to power the low power channel. As such, the low power channel is maintained in an active state for receiving scheduling information, such as an access schedule, during both idle and non-idle periods. <IMAGE>
2013 CMHS Uniform Reporting System (URS) Table for Pennsylvania

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for Pennsylvania for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
Compound 526184: 1-Methylbicyclo[3.3.0]-2,8-dioxa-4-thiaoctane

Chemical compound data from PubChem database. IUPAC Name: 3a-methyl-6,6a-dihydro-5H-furo[3,2-d][1,3]oxathiole. Molecular Formula: C6H10O2S. Molecular Weight: 146.21. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Food Service Establishment Inspections: Beginning 2005 (INACTIVE)

This data includes the name and location of inactive food service establishments and the violations that were found at the time of the inspection.  Inactive food service establishments include only establishments that are no longer in business or have not operated for an extended period of time. Inspections are a “snapshot” in time and are not always reflective of the day-to-day operations and overall condition of an establishment.  This dataset is refreshed on a monthly basis.
Patent AT-E401518-T1: [Translated] VALVE WITH EMERGENCY STOP DEVICE

The valve, comprising a body (1) with an inner fluid channel (4, 32) controlled by a shut-off element (8) and seat (9), incorporates a manually-operated emergency cut-out system that allows the fluid flow to be halted immediately and completely, and consists of a head (20) that moves along the axis (X - X') of the valve, and a bush (19) with a spiral cam slot. The cam slot receives a spindle (22) that can occupy two positions corresponding to the opening or closure of the fluid channel (4, 32), and either the head or bush co-operated directly or indirectly with a slider (25) controlling the shut-off element.
Patent AT-E40101-T1: [Translated] PYROTECHNIC FOG GENTS.

Chemical patent from PubChem database. Patent Number: AT-E40101-T1. Title: Crystalline Forms of Chemical Compounds. Filing Date: 2005-03-15. Inventors: Patel, Amit, Jones, Michael. Abstract: The invention provides novel crystalline forms of chemical compounds, characterized by specific X-ray powder diffraction patterns and thermal properti... IPC Classifications: C07D, C07F, A61K. This patent covers 24 claims related to 9 chemical compounds. Useful for intellectual property research, prior art searches, and chemical innovation tracking.
2013 CMHS Uniform Reporting System (URS) Table for Mississippi

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for Mississippi for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
Human rights in the biotechnology era 1

Backgound
          The concept of Human Rights has become the modern civilising standard to which all should aspire and indeed attain.
        
        
          Discussion
          In an era characterised by widening disparities in health and human rights across the world and spectacular advances in biotechnology it is necessary to reflect on the extent to which human rights considerations are selectively applied for the benefit of the most privileged people. Attention is drawn particularly to sub-Saharan Africa as a marginalised region at risk of further marginalisation if the power associated with the new biotechnology is not used more wisely than power has been used in the past. To rectify such deficiencies it is proposed that the moral agenda should be broadened and at the very least the concept of rights should be more closely integrated with duties
        
        
          Summary
          New forms of power being unleashed by biotechnology will have to be harnessed and used with greater wisdom than power has been used in the past. Widening disparities in the world are unlikely to be diminished merely by appealing to human rights. We recommend that a deeper understanding is required of the underlying causes of such disparities and that the moral discourse should be extended beyond human rights language.
Compound 527173: Butanoic acid, 3-methyl, 2-iodoethyl ester

Chemical compound data from PubChem database. IUPAC Name: 2-iodoethyl 3-methylbutanoate. Molecular Formula: C7H13IO2. Molecular Weight: 256.08. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 529626: 2-Butyl-4-methyl-1,3-dithiolane

Chemical compound data from PubChem database. IUPAC Name: 2-butyl-4-methyl-1,3-dithiolane. Molecular Formula: C8H16S2. Molecular Weight: 176.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 526659: 2,4-Pentadien-1-ol, 5-phenyl-, 1-acetate

Chemical compound data from PubChem database. IUPAC Name: 5-phenylpenta-2,4-dienyl acetate. Molecular Formula: C13H14O2. Molecular Weight: 202.25. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Inhibition of the MEK1/ERK pathway reduces arachidonic acid release independently of cPLA

Background
          The 85-kDa cytosolic phospholipase A2 (cPLA2) mediates arachidonic acid (AA) release in MDCK cells. Although calcium and mitogen-activated protein kinases regulate cPLA2, the correlation of cPLA2 translocation and phosphorylation with MAPK activation and AA release is unclear.
        
        
          Results
          MEK1 inhibition by U0126 inhibited AA release in response to ATP and ionomycin. This directly correlated with inhibition of ERK activation but not with phosphorylation of cPLA2 on Ser505, which was only partially inhibited by ERK inhibition. Inhibition of AA release by U0126 was still observed when stoichiometric phosphorylation of cPLA2 on Ser505 was maintained by activating p38 with anisomycin. Translocation kinetics of wild-type cPLA2 and cPLA2 containing S505A or S727A mutations to Golgi were similar in response to ATP and ionomycin and were not affected by U0126.
        
        
          Conclusions
          These results suggest that the ability of cPLA2 to hydrolyze membrane phospholipid is reduced by inhibition of the MEK1/ERK pathway and that the reduction in activity is independent of cPLA2 phosphorylation and translocation to membrane. The results also demonstrate that cPLA2 mutated at the phosphorylation sites Ser505 and Ser727 translocated with similar kinetic as wild-type cPLA2.
Compound 527435: 3-Mercapto-2-methylpentanal

Chemical compound data from PubChem database. IUPAC Name: 2-methyl-3-sulfanylpentanal. Molecular Formula: C6H12OS. Molecular Weight: 132.23. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.