AndreaBozzo/ceres-open-data-index huggingface dataset:
"Bronchial Artery Delivery of Viral Vectors for Gene delivery in Cystic Fibrosis; Superior to Airway Delivery?"

Background
          Attempts at gene therapy for the pulmonary manifestations of Cystic Fibrosis have relied mainly on airway delivery. However the efficiency of gene transfer and expression in the airway epithelia has not reached therapeutic levels. Access to epithelial cells is not homogenous for a number of reasons and the submucosal glands cannot be reached via the airways.
        
        
          Presentation
          We propose to inject gene delivery vectors directly into bronchial arteries combined with pre-delivery of vascular endothelial growth factor to increase vascular endothelial permeability and post-delivery flow reduction by balloon occlusion. Thus it may be possible to reach mucous secreting cells of the bronchial luminal epithelium and the submucosal glands in an increased and homogenous fashion.
        
        
          Testing
          This combination of techniques to the best of our knowledge has not previously been investigated, and may enable us to overcome some of the current limitations to gene therapy for Cystic Fibrosis.
Compound 530040: 10,13-Dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-17-carbaldehyde

Chemical compound data from PubChem database. IUPAC Name: 10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-17-carbaldehyde. Molecular Formula: C20H28O2. Molecular Weight: 300.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Program Instruction (PI-01-03)

This Program Instruction (PI) provides instruction to state on the June 30, 2001 submission of the Annual Progress and Services Report required for: title IV-B of the Social Security Act (the Act), the Child Abuse Prevention and Treatment Act, and the Chafee Foster Care Independence Program; and the CFS-101, Annual Budget Request and Annual Summary of Child and Family Services.

Metadata-only record linking to the original dataset. Open original dataset below.
2012 Uniform Reporting System (URS) Tables for Utah

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2012. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
Patent AT-E401657-T1: [Translated] ELECTRICAL SWITCHING DEVICE WITH REINFORCED ELECTRICAL CONTACTS

The switch has a mobile contactor element (30) connected to contact zones of fixed contactor elements (10, 20), where the elements are made of copper. The fixed contactor elements are in the form of coils and create an electromagnetic field (B) to form an attraction force (F) on the mobile element during passage of current. The fixed contactor elements are disposed opposite to each other, and the mobile contactor element is disposed between the coils to separate the contact zones of large height equal to the height of the coils.
Fiscal Intermediary Shared System Attending and Rendering

The Fiscal Intermediary Shared System (FISS) Attending and Rendering dataset provides a list of those attending and rendering physicians for the FISS. FISS edits require that the Line Item Rendering Physician information be transmitted when providers submit a combined claim. Claims that include both facility and professional components, need to report the rendering physician or other practitioner at the line level if it differs from the rendering physician/practitioner reported at the claim level.

 

Note: This full dataset contains more records than most spreadsheet programs can handle, which will result in an incomplete load of data. Use of a database or statistical software is required.
Elk Creek Seismic Waveforms 2011 (Part 19 of 19)

Coal bursts (damaging seismic events in underground coal mines) pose a substantial threat to operations and mine workers. The underground coal mines in Colorado’s North Fork Valley (NFV) have experienced many coal bursts, often with distinct characteristics from those of other US coal mining regions. To better understand these events and manage their associated risks, the National Institute for Occupational Safety and Health undertook a long-term monitoring campaign at the Elk Creek Mine in the NFV. The monitoring efforts included a seismic network composed of both surface and underground sensors, borehole pressure cells (BPCs), instrumented support Cans, convergence monitors, ground condition surveys, and several other data sources. This dataset consists of the event waveform files from the seismic network for the 983,379 events that were detected during the monitoring campaign. The waveforms are stored in HDF5 files that are broken up by week. Within the HDF5 files, the data are organized by station id, event time, and channel. The amplitudes are velocity in meters/second.
 
This is download 27 of 48 and corresponds to the time range between December 26, 2011, and January 2, 2012.
West Virginia (WV)

This report presents West Virginia\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for West Virginia for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.
Elevated calcitonin precursor levels are related to mortality in an
		  animal model of sepsis

Background:
          Increased serum levels of procalcitonin (ProCT) and its component
				peptides have been reported in humans with sepsis. Using a hamster model of
				bacterial peritonitis, we investigated whether serum ProCT levels are elevated
				and correlate with mortality and hypocalcemia.
        
        
          Results:
          Incremental increases in doses of bacteria resulted in
				proportional increases in 72h mortality rates (0, 20, 70, and 100%) as well as
				increases in serum total immunoreactive calcitonin (iCT) levels at 12 h (250,
				380, 1960, and 4020 pg/ml, respectively, vs control levels of 21 pg/ml).
				Gel filtration studies revealed that ProCT was the predominant (> 90%)
				molecular form of serum iCT secreted. In the metabolic experiments, total iCT
				peaked at 12 h concurrent with the maximal decrease in serum calcium.
        
        
          Conclusions:
          In this animal model, hyper-procalcitoninemia was an early
				systemic marker of sepsis which correlated closely with mortality and had an
				inverse correlation with serum calcium levels.
Publications Using SAMHSA DataN-SUMHSS 2022 Questionnaire

This is the questionnaire for the 2022 National Substance Use and Mental Health Services Survey (N-SUMHSS). The N-SUMHSS is a voluntary annual survey of all active substance use and mental health facilities in the United States, its jurisdictions, and the District of Columbia. This document shows the series of questions mental health and substance abuse treatment facilities were asked for the N-SUMHSS.The survey consists of two introductory questions and four separate modules. Skip patterns in the survey direct participants on relevant modules depending on whether the facility is a substance use treatment facility, a mental health treatment facility, or both.Additionally, facilities operated by the Department of Veteran’s Affairs (VA) were asked to complete additional questions regarding VA services offered.The web questionnaire and other addenda are available as PDF files.
Compound 526227: 1,2,3,6,7-Pentabromo-dibenzofuran

Chemical compound data from PubChem database. IUPAC Name: 1,2,3,6,7-pentabromodibenzofuran. Molecular Formula: C12H3Br5O. Molecular Weight: 562.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Down-regulation of the alpha-2C adrenergic receptor: involvement of a serine/threonine motif in the third cytoplasmic loop

Background
          The mechanisms by which alpha-2 adrenergic receptors are down-regulated following chronic exposure to agonist are not well understood. Interestingly, the human alpha-2C receptor does not down-regulate, whereas the opossum alpha-2C receptor does down-regulate. A comparison of the amino acid sequence of the third intracellular loop of these two receptors shows that the opossum alpha-2C receptor contains a potential G protein-coupled receptor kinase (GRK)phosphorylation motif (EESSTSE) with four hydroxyl residues, whereas the human alpha-2C receptor motif only contains two hydroxyl residues (DESSAAAAE). Because a similar acidic serine-rich motif (EESSSSD) in the human alpha-2 adrenergic receptor has been demonstrated to be phosphorylated by GRK and all four serines are required for desensitization of the receptor, we sought to determine whether the EESSTSE sequence was involved in the down-regulation of the alpha-2C adrenergic receptor.
        
        
          Results
          Site-directed mutagenesis was used to mutate the opossum alpha-2C receptor to SSVA and AAVA in place of the SSTS wild-type sequence. Down-regulation experiments on CHO cells transfected with the receptors demonstrated that neither of the mutated receptors down-regulated following 24 h exposure to norepinephrine, whereas the wild-type receptor down-regulated to 65 ± 10% of the control.
        
        
          Conclusions
          These results indicate that a motif with four hydroxyl amino acid residues in an acidic environment is important for down-regulation of the opossum alpha-2C adrenergic receptor. Because these are potential GRK phosphorylation sites, we suggest that GRK phosphorylation may be involved in alpha-2C adrenergic receptor down-regulation.
What you should know about PR3-ANCA: Conformational requirements of proteinase 3 (PR3) for enzymatic activity and recognition by PR3-ANCA

The neutrophil azurophil granule constituent proteinase 3 (PR3) is the principal antigen for anti-neutrophil cytoplasmic antibodies (ANCA) in Wegener's granulomatosis. The conformation of the mature PR3 enzyme results from intracellular post-translational processing. The nascent molecule undergoes proteolytic cleavage of the amino-terminal signal peptide and activation dipeptide and of a carboxy-terminal peptide extension. The conformation of PR3 is stabilized by four disulfide bonds and, to a lesser extent, by asparagine-linked glycosylation. Most anti-neutrophil cytoplasmic antibodies directed against proteinase 3 (PR3-ANCA) recognize conformational epitopes. The expression of recombinant PR3 has provided a better understanding of the significance of the various intracellular processing steps for enzymatic activity and recognition by PR3-ANCA.
State Panel Discussion Recording Intake Calls

The Children's Bureau, Division of State Systems (DSS) hosted a state panel discussion about recording intake calls. The panel, consisting of representatives from Colorado, Iowa, and New Jersey, responded to questions about their reasons for recording intake calls, how their child welfare service providers use the recordings, and about their lessons learned. The webinar concluded with a question and answer segment.

Metadata-only record linking to the original dataset. Open original dataset below.
Compound 526009: 3,17,20,21-Tetrakis[(trimethylsilyl)oxy]pregnan-11-one

Chemical compound data from PubChem database. IUPAC Name: 17-[1,2-bis(trimethylsilyloxy)ethyl]-10,13-dimethyl-3,17-bis(trimethylsilyloxy)-2,3,4,5,6,7,8,9,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-11-one. Molecular Formula: C33H66O5Si4. Molecular Weight: 655.2. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E399836-T1: [Translated] SYNTHESIS OF ESTER LINKED LONG CHAIN ALKYL GROUPS

A process for preparing a mixture of cetyl myristate and cetyl palmitate comprising reacting both myristic and palmitic acid with cetyl alcohol with an acid catalyst and one aromatic hydrocarbon at an elevated temperature and recovering from the aromatic hydrocarbon fraction the cetyl myristate and cetyl palmitate.
Weekly Influenza Vaccination Status and Intent for Vaccination, Overall, by Selected Demographics, and Jurisdiction, Children 6 Months - 17 Years, 2023-24, United States

• Influenza vaccination coverage and parental intent among children 6 months to 17 years is assessed through the National Immunization Survey-Child COVID Module providing weekly COVID-19 vaccination coverage estimates. (https://www.cdc.gov/vaccines/imz-managers/nis/about.html)

• For the 2023-2024 flu season, the CDC recommends a flu shot for most people 6 months and older.
Patent AT-E399787-T1: [Translated] PSE GROUP 4 METAL COMPLEXES CONTAINING 4-ARYL SUBSTITUTED TRICYCLIC INDENYL DERIVATIVES

Group 4 metal constrained geometry complexes comprising tricyclic 4-arylsubstituted indenyl ligands, especially 1,5,6,7-tetrahydro-4-aryl-s-indacen-1-yl ligands, catalytic derivatives thereof, processes for preparing the same and their use as components of olefin polymerization catalysts are disclosed.
Value Set Authority Center

The VSAC is a repository and authoring tool for public value sets created by external programs. Value sets are lists of codes and corresponding terms, from NLM-hosted standard clinical vocabularies (such as SNOMED CT®, RxNorm, LOINC® and others), that define clinical concepts to support effective and interoperable health information exchange. The VSAC does not create value set content. The VSAC also provides downloadable access to all official versions of value sets specified by the Centers for Medicare & Medicaid Services (CMS) electronic Clinical Quality Measures (eCQMs). For information on CMS eCQMs, visit the eCQI Resource Center. The VSAC is provided by the National Library of Medicine (NLM), in collaboration with the Office of the National Coordinator for Health Information Technology (ONC) and CMS.
Compound 526964: meta,meta'-alpha-Hydroxydinitrodiphenylacetic acid, methyl ester

Chemical compound data from PubChem database. IUPAC Name: methyl 2-hydroxy-2,2-bis(3-nitrophenyl)acetate. Molecular Formula: C15H12N2O7. Molecular Weight: 332.26. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E401139-T1: [Translated] COATING APPARATUS AND METHOD

A coating apparatus (100) and coating method include a device for conveying an object (W) to be coated; a coating device (4) which is disposed in a vicinity of a conveyed surface of the object (W), and which discharges a coating liquid, and which forms a bridge of the liquid between the device (4) and the object (W) which is conveyed by the device for conveying an object to be coated, and which coats the liquid on at least one surface of the object (W); and a gas stream blowing device which, immediately after starting of coating, blows out a gas from a direction substantially opposite to a object conveying direction, toward a portion of the object where coating starts. <IMAGE>
Partners in Information Access for the Public Health Workforce (PHPartners) (retired September 14, 2021)

Partners in Information Access for the Public Health Workforce (PHPartners) is a web portal and current awareness service of information for the public health workforce. Alerts the communities to meetings, webinars, new web-born reports (analyses, statistics), datasets, and general news. Currently contains over 4,000 items.

This resource was retired on September 14, 2021 and is no longer updated.
Compound 526543: 9-(2-Hydroxy-3-methylbutyryl)-retronecine

Chemical compound data from PubChem database. IUPAC Name: (6-hydroxy-5,6,7,8-tetrahydro-3H-pyrrolizin-1-yl)methyl 2-hydroxy-3-methylbutanoate. Molecular Formula: C13H21NO4. Molecular Weight: 255.31. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
A prospective study of tracheopulmonary complications associated with the placement of narrow-bore enteral feeding tubes

Background:
          In order to determine the type and incidence of pulmonary complications associated with the placement of narrow-bore enteral feeding tubes we conducted a prospective, descriptive study in the multidisciplinary intensive care unit (ICU) of a university hospital. All patients that had narrow-bore enteral feeding tubes inserted over a 2-year period (1993-1995) were included. The study required no clinical interventions.
        
        
          Results:
          Seven hundred and forty feeding tubes were inserted during the study period. In 14 cases (2%), the feeding tube was inserted into the tracheopulmonary system. Five patients (0.7%) suffered a major complication, including two (0.3%) who died from complications directly related to the feeding tube placement. All patients had altered consciousness and 13 of the 14 had endotracheal tubes in place. Malposition of the feeding tube was not predictable from clinical signs and auscultation, but was detectable by chest roentgenogram.
        
        
          Conclusions:
          Inadvertent insertion of enteral feeding tubes into the tracheopulmonary system during placement is associated with significant morbidity and mortality. Clinical signs at the time of insertion are not useful in identifying feeding tubes which are malpositioned. In the ICU patient, a chest roentgenogram is required after all feeding tube insertions prior to the initiation of enteral feeding. In the high-risk patient, alternatives to blind feeding tube insertion should be considered.
National Directory of Drug and Alcohol Abuse Treatment Programs 2013

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) annual report that includes the National Directory of Drug and Alcohol Abuse Treatment Programs in 2013. The National Directory of Drug and Alcohol Abuse Treatment Program is a listing of Federal, State, and local government facilities and private facilities that provide substance abuse treatment services. It includes treatment facilities that (1) are licensed, certified, or otherwise approved for inclusion in the Directory by their State substance abuse agencies, and (2) responded to the 2012 National Survey of Substance Abuse Treatment Services (N-SSATS). N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.
Patent AT-E400312-T1: [Translated] DEVICE AND METHOD FOR THE QUALITATIVE AND QUANTITATIVE DETERMINATION OF INTRAVENOUS FLUID COMPONENTS

A device and process for preventing medical errors due to the improper administration of an intravenously delivered medication includes the spectroscopic analysis of intravenous fluid components. An emission source and detector are placed adjacent to the intravenous tubing of an administration set to generate signals for spectroscopic analysis. The signals are processed to identify the medication and, in certain embodiments of the invention, can determine the medication's concentration. In a preferred embodiment, the emission source, detector, and hardware and software for the spectroscopic analysis are placed in an infusion pump.
Compound 530262: 1,3,5-tris-(Hydroxymethyl)cyclohexane, triacetate

Chemical compound data from PubChem database. IUPAC Name: [3,5-bis(acetyloxymethyl)cyclohexyl]methyl acetate. Molecular Formula: C15H24O6. Molecular Weight: 300.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 530667: 4-Butylbenzoic acid, 2,7-dimethyloct-7-en-5-yn-4-yl ester

Chemical compound data from PubChem database. IUPAC Name: 2,7-dimethyloct-7-en-5-yn-4-yl 4-butylbenzoate. Molecular Formula: C21H28O2. Molecular Weight: 312.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Phenotypic characteristics of human monocytes undergoing transendothelial migration

In our study we characterised the immunophenotype of monocytes that migrated through an endothelial cell (EC) monolayer in vitro. We found that monocyte migration led to an enhanced expression of CD11a, CD33, CD45RO, CD54 [intercellular cell-adhesion molecule (ICAM)-1] and human leucocyte antigen-DR. The most striking increase was observed for ICAM-1 when ECs were activated with tumour necrosis factor-α and interleukin-1α. The results of our study indicate the following: (1) there is a characteristic immunophenotype on the surface of monocytes after transendothelial migration; (2) this phenotype seems to be induced by interactions between monocytes and ECs; and (3) this change is enhanced by the pretreatment of ECs with cytokines. Taken together, the results suggest that local cytokine production activating ECs is sufficient to enhance monocyte migration and that this, in turn, can induce changes consistent with an activated phenotype known to be interactive between antigen-presenting cells and T cells. These results have implications for our pathogenetic insights into rheumatoid arthritis.
Compound 529541: 2-Deca-2,9-dienyl-3-pent-2-enyloxirane

Chemical compound data from PubChem database. IUPAC Name: 2-deca-2,9-dienyl-3-pent-2-enyloxirane. Molecular Formula: C17H28O. Molecular Weight: 248.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E401662-T1: [Translated] CONTROL UNIT WITH THERMAL PROTECTION AND AN ELECTRIC HEATING DEVICE COMPRISING THE CONTROL UNIT

In its normal position fixed opposite a printed circuit board (PCB) (1), a contact breaker (CB) (3) forms an electrical interconnection between opposing ends on a strip conductor. Activated by overheating in a transistor (2), an operating element (4) acts against the CB when activated and detaches the CB so far from the PCB that an electrical connection is interrupted. Independent claims are also included for the following: (A) A pre-assembled operating unit for a contact breaker in an electromechanical overheating protection device; (B) and for an electric heating device with a layered casing, a radiator element, a metal contact sheet and an exothermic element.
Compound 527516: 3-Methylbutyl 2-bromobutanoate

Chemical compound data from PubChem database. IUPAC Name: 3-methylbutyl 2-bromobutanoate. Molecular Formula: C9H17BrO2. Molecular Weight: 237.13. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 526948: 2-(3-Thienyldithio)pentan-3-one

Chemical compound data from PubChem database. IUPAC Name: 2-(thiophen-3-yldisulfanyl)pentan-3-one. Molecular Formula: C9H12OS3. Molecular Weight: 232.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.