AndreaBozzo/ceres-open-data-index huggingface dataset:
Phoenix: Drug-Related Emergency Department Visits, 2004-2011 - Suicide Attempts

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving suicide attempts in the Phoenix metropolitan area, covering 2004-2011.  Drug-related suicide attempts include visits for drug overdoses and for suicide attempts by other means (e.g., using a firearm) if drugs were involved or related to the suicide attempt.
Daily Census Tract-Level Ozone Concentrations, 2011-2015

This dataset provides modeled predictions of ozone levels from the EPA's Downscaler model. Data are at the census tract level for 2001-2005. These data are used by the CDC's National Environmental Public Health Tracking Network to generate air quality measures. Census tract-level datasets contain estimates of the mean predicted concentration and associated standard error. Please refer to the metadata attachment for more information.

Learn more about outdoor air quality on the Tracking Network's website: https://ephtracking.cdc.gov/showAirLanding.action.

By using these data, you signify your agreement to comply with the following requirements:
1. Use the data for statistical reporting and analysis only.
2. Do not attempt to learn the identity of any person included in the data and do not combine these data with other data for the purpose of matching records to identify individuals.
3. Do not disclose of or make use of the identity of any person or establishment discovered inadvertently and report the discovery to: trackingsupport@cdc.gov.
4. Do not imply or state, either in written or oral form, that interpretations based on the data are those of the original data sources and CDC unless the data user and data source are formally collaborating.
5. Acknowledge, in all reports or presentations based on these data, the original source of the data and CDC.
6. Suggested citation: Centers for Disease Control and Prevention. National Environmental Public Health Tracking Network. Web. Accessed: insert date. www.cdc.gov/ephtracking.
Patent AT-E400537-T1: [Translated] FIREPROOF COMPOSITION AND METHOD FOR REPAIRING WARM FIREPROOF MASONRY

The present invention relates to refractory composition consisting essentially of 40-90 dry weight % of amorphous silica aggregates, up to 40 dry weight % of alumina based compounds, 10-15 dry weight % of clay, 0.2-2.0 dry weight % of a chemical binder and further containing 2 to 8 % of water. <??>These compositions are particularly useful for the repair of coke oven damaged wall in a gunning process.
New Legislation Affecting Child Welfare Services: Division X and Section 305 of the Consolidated Appropriations Act, 2021

This Information Memorandum (IM) informs title IV-B and IV-E agencies and State and Tribal Court Improvement Programs of the enactment of Division X and Section 305 of Title III of Division CC of the Consolidated Appropriations Act, 2021 and provides basic information on the new law.

Metadata-only record linking to the original dataset. Open original dataset below.
2013-2014 NSDUH State Estimates of Substance Use and Mental Disorders

State estimates for 25 measures of substance use and mental disorders based on the combined 2013 and 2014 National Surveys on Drug Use and Health (NSDUHs) are provided. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Results are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older, and all persons 12 or older. State and census region estimates are based on a small area estimation (SAE) methodology in which State-level NSDUH data are combined with county and census block group/tract-level data from the State.
Number of Accountable Care Organization Assigned Beneficiaries by County

The Shared Savings Program Number of Accountable Care Organization Assigned Beneficiaries by County dataset provides aggregate data of total assigned beneficiaries by Shared Savings Program ACO for each county where at least one of their assigned beneficiaries resides. Assigned beneficiary person-year counts are based on certified Shared Savings Program ACO Participant Lists and assignment methodology for that performance year.
NNDSS - TABLE 1W. Meningococcal disease, All serogroups to Meningococcal disease, Serogroup B

NNDSS - TABLE 1W.  Meningococcal disease,  All serogroups to Meningococcal disease, Serogroup B - 2019. In this Table, provisional cases* of notifiable diseases are displayed for United States, U.S. territories, and Non-U.S. residents. 

Note: 
This table contains provisional cases of national notifiable diseases from the National Notifiable Diseases Surveillance System (NNDSS). NNDSS data from the 50 states, New York City, the District of Columbia and the U.S. territories are collated and published weekly on the NNDSS Data and Statistics web page (https://wwwn.cdc.gov/nndss/data-and-statistics.html). Cases reported by state health departments to CDC for weekly publication are provisional because of the time needed to complete case follow-up. Therefore, numbers presented in later weeks may reflect changes made to these counts as additional information becomes available. The national surveillance case definitions used to define a case are available on the NNDSS web site at https://wwwn.cdc.gov/nndss/. Information about the weekly provisional data and guides to interpreting data are available at: https://wwwn.cdc.gov/nndss/infectious-tables.html. 

Footnotes:
U: Unavailable — The reporting jurisdiction was unable to send the data to CDC or CDC was unable to process the data.
-: No reported cases — The reporting jurisdiction did not submit any cases to CDC.
N: Not reportable — The disease or condition was not reportable by law, statute, or regulation in the reporting jurisdiction.
NN: Not nationally notifiable — This condition was not designated as being nationally notifiable.
NP: Nationally notifiable but not published — CDC does not have data because of changes in how conditions are categorized.
Cum: Cumulative year-to-date counts.
Max: Maximum — Maximum case count during the previous 52 weeks.
* Case counts for reporting years 2018 and 2019 are provisional and subject to change. Cases are assigned to the reporting jurisdiction submitting the case to NNDSS, if the case's country of usual residence is the US, a US territory, unknown, or null (i.e. country not reported); otherwise, the case is assigned to the 'Non-US Residents' category. For further information on interpretation of these data, see https://wwwn.cdc.gov/nndss/document/Users_guide_WONDER_tables_cleared_final.pdf. 
† Previous 52 week maximum and cumulative YTD are determined from periods of time when the condition was reportable in the jurisdiction (i.e., may be less than 52 weeks of data or incomplete YTD data).
Molecular diversity of phospholipase D in angiosperms

Background
          The phospholipase D (PLD) family has been identified in plants by recent molecular studies, fostered by the emerging importance of plant PLDs in stress physiology and signal transduction. However, the presence of multiple isoforms limits the power of conventional biochemical and pharmacological approaches, and calls for a wider application of genetic methodology.
        
        
          Results
          Taking advantage of sequence data available in public databases, we attempted to provide a prerequisite for such an approach. We made a complete inventory of the Arabidopsis thaliana PLD family, which was found to comprise 12 distinct genes. The current nomenclature of Arabidopsis PLDs was refined and expanded to include five newly described genes. To assess the degree of plant PLD diversity beyond Arabidopsis we explored data from rice (including the genome draft by Monsanto) as well as cDNA and EST sequences from several other plants. Our analysis revealed two major PLD subfamilies in plants. The first, designated C2-PLD, is characterised by presence of the C2 domain and comprises previously known plant PLDs as well as new isoforms with possibly unusual features-catalytically inactive or independent on Ca2+. The second subfamily (denoted PXPH-PLD) is novel in plants but is related to animal and fungal enzymes possessing the PX and PH domains.
        
        
          Conclusions
          The evolutionary dynamics, and inter-specific diversity, of plant PLDs inferred from our phylogenetic analysis, call for more plant species to be employed in PLD research. This will enable us to obtain generally valid conclusions.
Role of gammadelta T cells in protecting normal airway function

Since their discovery 15 years ago, the role of γδ T cells has remained somewhat elusive. Responses of γδ T cells have been found in numerous infectious and non-infectious diseases. New evidence points to γδ T cells' functioning in the airways to maintain normal airway responsiveness or tone. In the lung, distinct subsets of γδ T cell subsets seem to have specific roles, one subset promoting allergic inflammation, the other serving a protective role.
Compound 527820: 4-(Octyloxy)-3-chlorophenylacetic acid

Chemical compound data from PubChem database. IUPAC Name: 2-(3-chloro-4-octoxyphenyl)acetic acid. Molecular Formula: C16H23ClO3. Molecular Weight: 298.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Managed Care Institutional Provider Network Data: March 31, 2016

The primary purpose for the Provider Network Data System is to collect data needed to evaluate the provider networks including physicians, hospitals, labs, home health agencies, durable medical equipment providers, etc., for all types of Managed Care plans in New York State, including HIV Special Need Plans (SNP), Family Health Plus (FHP) Buy-In, Programs of All-Inclusive Care for the Elderly (PACE), and Non-PACE Managed Long-Term Care (MLTC) plans. This dataset reflects institutional provider data. Provider Network Data System information is self reported. For more information, go to http://www.health.ny.gov/health_care/managed_care/.
Patent AT-E400295-T1: [Translated] VACCINE WITH A POLYSACCHARIDE ANTIGEN CARRIER PROTEIN CONJUGATE AND FREE CARRIER PROTEIN

The present invention relates to combination vaccines comprising a conjugated polysaccharide antigen linked to a carrier protein, and wherein the carrier protein is also present as a free antigen in the vaccine composition, characterised in that the ratio of polysaccharide to protein is from 1:0:3 to 1:2. In particular the vaccine composition of the present invention relates to a multivalent vaccine, that is a vaccine for the amelioration or treatment of more than one disease states. The present invention also relates to the production and use of such a vaccine in medicine.
Compound 526202: 2,4-Tert-butyl-6-hydroperoxymethyl-phenol

Chemical compound data from PubChem database. IUPAC Name: 2,4-ditert-butyl-6-(hydroperoxymethyl)phenol. Molecular Formula: C15H24O3. Molecular Weight: 252.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Oklahoma 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.
Patent AT-E399528-T1: [Translated] SPRAYABLE SUN PROTECTION PREPARATION BASED ON SPHERICAL SILICIC ACID MICROPARTICLES AND PRESSURE CONTAINER CONTAINING THE SUN PROTECTION PREPARATION

Device comprising a reservoir containing a sunscreen composition and means for pressurizing the composition, which comprises a UV filter system and porous silica microspheres, is new.  An Independent claim is also included for the use of porous silica microspheres for increasing the sun protection factor (SPF) of a vaporizable composition comprising a UV filter system in an aqueous carrier.
2014 CMHS Uniform Reporting System (URS) Table for Illinois

2014 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Illinois. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
Results from the 2014 National Survey on Drug Use and Health:  Detailed Tables

Results from the 2014 National Survey on Drug Use and Health: Detailed Tables is a collection of tables presenting national estimates from the National Survey on Drug Use and Health (NSDUH). These tables present information on drug, alcohol, and tobacco use, as well as drug and alcohol dependence and abuse and treatment. Measures of these behaviors and characteristics are presented by a variety of demographic, geographic, and other variables. The estimates in the tables include rates of the behaviors, numbers of persons engaging in these behaviors, and other measures. Although the majority of these tables are trend tables presenting estimates from the 2013 and 2014 NSDUHs, some tables include only estimates from the 2014 NSDUH.
2020 NSDUH Detailed Tables

Get detailed national estimates from the 2020 National Survey on Drug Use and Health (NSDUH). The tables provide comprehensive statistics on substance use, mental health, and treatment in the United States. Although past year estimates are provided, they cannot be compared to 2020 estimates. This is because changes in survey methodology mean the indicators are not comparable to past NSDUH estimates.The tables are based on the NSDUH survey, which interviews people ages 12 or older in the civilian, noninstitutionalized population. In the tables, indicators are broken out by a variety of demographic, geographic, and economic variables.The following topics are covered, among others: drug, alcohol, nicotine, and tobacco product use and initiation; substance use disorder (SUD); substance use risk and protective factors; availability of substance use treatment; any mental illness (AMI) and serious mental illness (SMI); major depressive episode (MDE); suicidal thoughts and behaviors; serious psychological distress (SPD); mental health service utilization; treatment for depression; and co-occurrence of mental health issues and SUDs. In 2020, these tables also present the perceived effects of the Coronavirus Disease 2019 (COVID-19) pandemic on substance use and mental health.1All of the tables can be downloaded in a zip file which contains both an html and PDF file containing every table. Alternatively, users can open the clickable Table of Contents to go to a particular section. Click on “PE” to get to a population estimate or percentage table, and “SE” to get a standard error table.1. Please note that selected tables have been revised.
MD COVID-19 - Total Confirmed Deaths Statewide

<b>Note:</b> Starting April 27, 2023 updates change from daily to weekly.

<b>Summary</b>
The cumulative number of confirmed COVID-19 deaths among Maryland residents.

<b>Description</b>
The MD COVID-19 - Total Confirmed Deaths Statewide data layer is a collection of the statewide confirmed COVID-19 related deaths that have been reported each day by the Vital Statistics Administration. A death is classified as confirmed if the person had a laboratory-confirmed positive COVID-19 test result. Some data on deaths may be unavailable due to the time lag between the death, typically reported by a hospital or other facility, and the submission of the complete death certificate. Probable deaths are available from the MD COVID-19 - Total Probable Deaths Statewide data layer. 
Update 5/27/21: The Maryland Department of Health (MDH) Vital Statistics Administration (VSA) revised the state’s COVID-19 data to include deaths that were not properly classified by medical certifiers over the past year. VSA identified these deaths as COVID-19 deaths through an information reconciliation process utilizing other sources of data. Learn more: https://health.maryland.gov/newsroom/Pages/Maryland-Department-of-Health-Vital-Statistics-Administration-issues-revision-of-COVID-19-death-data.aspx

<b>Terms of Use</b>
The Spatial Data, and the information therein, (collectively the "Data") is provided "as is" without warranty of any kind, either expressed, implied, or statutory. The user assumes the entire risk as to quality and performance of the Data. No guarantee of accuracy is granted, nor is any responsibility for reliance thereon assumed. In no event shall the State of Maryland be liable for direct, indirect, incidental, consequential or special damages of any kind. The State of Maryland does not accept liability for any damages or misrepresentation caused by inaccuracies in the Data or as a result to changes to the Data, nor is there responsibility assumed to maintain the Data in any manner or form. The Data can be freely distributed as long as the metadata entry is not modified or deleted. Any data derived from the Data must acknowledge the State of Maryland in the metadata.
Early response genes induced in chondrocytes stimulated with the inflammatory cytokine interleukin-1beta

Recent work has established that IL-1β plays a central role in the inflammation and connective tissue destruction observed in both rheumatoid arthritis and osteoarthritis. These processes result from the ability of this inflammatory cytokine to activate expression of genes for neutral proteases, such as the matrix metalloproteinases. While IL-1β activates matrix metalloproteinase genes within several hours, it also activates immediate early genes, which are required for the later expression of matrix metalloproteinases and other arthritis-perpetuating genes, are also activated. To identify putative immediate early genes involved in IL-1β-mediated arthritic disease, a chondrocytic cell line (SW1353) was stimulated with this cytokine for 2 hours, total RNA was isolated, and expressed genes were identified by microarray analysis. This analysis identified alterations in the expression of multiple transcription factors, cytokines, growth factors and their receptors, adhesion molecules, proteases, and signaling intermediates that may contribute to inflammation and cartilage destruction in arthritis. Interestingly, confirmation of the expression of activating protein-1 family members by reverse transcriptase polymerase chain reaction revealed a preferential increase in junB, a known transcriptional antagonist of c-jun. The failure to observe induction of early growth response gene-1, which was detected by reverse transcriptase polymerase chain reaction to be substantially and transiently induced by 1 hour of IL-1 treatment, may be explained by the known instability of the message after early induction. However, this analysis has identified numerous IL-1β-responsive genes that warrant further investigation as mediators of disease in arthritis.
Patent AT-E401415-T1: [Translated] DIRECT RT-PCR ON MICROTITER PLATES WITH IMMOBILIZED OLIGONUCLEOTIDE

The entire process of reverse transcription-polymerase chain reaction (RT-PCR) is simplified by using oligonucleotide-immobilized microplates made of, e.g., polypropylene, to which oligonucleotides are securely immobilized and which can be subjected to thermal cycles of PCR. RT-PCR is preferably conducted in solid-phase. Capturing of mRNA and RT-PCR can be conducted in the same plates. The cDNA synthesized from the mRNA captured on the microplates can be used more than once. Further, in combination with the microplates, a filter plate is used for the preparation of cell lysates wherein target cells are placed on the filter plate, and a lysis buffer is passed through the cell layer on the filter to transfer cell lysate directly to the microplate via well-to-well communication.
Survey of human mitochondrial diseases using new genomic/proteomic tools

Background
          We have constructed Bayesian prior-based, amino-acid sequence profiles for the complete yeast mitochondrial proteome and used them to develop methods for identifying and characterizing the context of protein mutations that give rise to human mitochondrial diseases. (Bayesian priors are conditional probabilities that allow the estimation of the likelihood of an event - such as an amino-acid substitution - on the basis of prior occurrences of similar events.) Because these profiles can assemble sets of taxonomically very diverse homologs, they enable identification of the structurally and/or functionally most critical sites in the proteins on the basis of the degree of sequence conservation. These profiles can also find distant homologs with determined three-dimensional structures that aid in the interpretation of effects of missense mutations.
        
        
          Results
          This survey reports such an analysis for 15 missense mutations, one insertion and three deletions involved in Leber's hereditary optic neuropathy, Leigh syndrome, mitochondrial neurogastrointestinal encephalomyopathy, Mohr-Tranebjaerg syndrome, iron-storage disorders related to Friedreich's ataxia, and hereditary spastic paraplegia. We present structural correlations for seven of the mutations.
        
        
          Conclusions
          Of the 19 mutations analyzed, 14 involved changes in very highly conserved parts of the affected proteins. Five out of seven structural correlations provided reasonable explanations for the malfunctions. As additional genetic and structural data become available, this methodology can be extended. It has the potential for assisting in identifying new disease-related genes. Furthermore, profiles with structural homologs can generate mechanistic hypotheses concerning the underlying biochemical processes - and why they break down as a result of the mutations.
Tislelizumab-jsgr

TEVIMBRA (tislelizumab-jsgr) is an intravenous injection used as an immunotherapy drug that blocks programmed death receptor-1 (PD-1) to help the immune system fight certain cancers. Manufactured by BeOne Medicines USA, Inc., it's available as a 10 mg/mL solution concentrate, approved under BLA761232 and marketed since March 2024. This information was generated using AI and is provided for informational and research purposes only.
Compound 527832: N-alpha-Methyl lysine, butyl ester, TFA

Chemical compound data from PubChem database. IUPAC Name: butyl 2-[methyl-(2,2,2-trifluoroacetyl)amino]-6-[(2,2,2-trifluoroacetyl)amino]hexanoate. Molecular Formula: C15H22F6N2O4. Molecular Weight: 408.34. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.