AndreaBozzo/ceres-open-data-index huggingface dataset:
Mental health first aid training for the public: evaluation of effects on knowledge, attitudes and helping behavior

Background
          Many members of the public have poor mental health literacy. A Mental Health First Aid training course was developed in order to improve this. This paper describes the training course and reports an evaluation study looking at changes in knowledge, stigmatizing attitudes and help provided to others.
        
        
          Methods
          Data are reported on the first 210 participants in public courses. Evaluation questionnaires were given at the beginning of courses, at the end and at 6 months follow-up. Data were analyzed using an intention-to-treat approach.
        
        
          Results
          The course improved participants' ability to recognize a mental disorder in a vignette, changed beliefs about treatment to be more like those of health professionals, decreased social distance from people with mental disorders, increased confidence in providing help to someone with a mental disorder, and increased the amount of help provided to others.
        
        
          Conclusions
          Mental Health First Aid training appears to be an effective method of improving mental health literacy which can be widely applied.
Ultrastructure of acetylcholine receptor aggregates parallels mechanisms of aggregation

Background
          Acetylcholine receptors become aggregated at the developing neuromuscular synapse shortly after contact by a motorneuron in one of the earliest manifestations of synaptic development. While a major physiological signal for receptor aggregation (agrin) is known, the mechanism(s) by which muscle cells respond to this and other stimuli have yet to be worked out in detail. The question of mechanism is addressed in the present study via a quantitative examination of ultrastructural receptor arrangement within aggregates.
        
        
          Results
          In receptor rich cell membranes resulting from stimulation by agrin or laminin, or in control membrane showing spontaneous receptor aggregation, receptors were found to be closer to neighboring receptors than would be expected at random. This indicates that aggregation proceeds heterogeneously: nanoaggregates, too small for detection in the light microscope, underlie developing microaggregates of receptors in all three cases. In contrast, the structural arrangement of receptors within nanoaggregates was found to depend on the aggregation stimulus. In laminin induced nanoaggregates receptors were found to be arranged in an unstructured manner, in contrast to the hexagonal array of about 10 nm spacing found for agrin induced nanoaggregates. Spontaneous aggregates displayed an intermediate amount of order, and this was found to be due to two distinct population of nanoaggregates.
        
        
          Conclusions
          The observations support earlier studies indicating that mechanisms by which agrin and laminin-1 induced receptor aggregates form are distinct and, for the first time, relate mechanisms underlying spontaneous aggregate formation to aggregate structure.
Patent AT-E401428-T1: [Translated] WEAR PROTECTION LAYER FOR A SHAPING TOOL

A machine tool has a cutting edge that has an anti-wear coating consisting of a metallic component and a non-metallic component. The metallic component incorporates aluminium, 1-40%chrome, 2-25% titanium and 0.5 to 4% yttrium. These figures refer to the metallic atomic percentage in the material. The non-metallic portion incorporates nitrogen and oxygen in the form of an oxynitride with 1-10% nitrogen and 1-8% oxygen.
Effect of simvastatin on bone markers in osteopenic women: a placebo-controlled, dose-ranging trial [ISRCTN85429598]

Background
          Hydroxymethylglutaryl coenzyme A reductase inhibitors increase new bone formation in vitro and in rodents. Results of epidemiologic analyses evaluating the association between use of these cholesterol-lowering drugs, bone mineral density and fracture have been mixed.
        
        
          Methods
          Women (n = 24) with osteopenia, assessed by broad band ultrasound attenuation, were randomized to simvastatin 20 mg, 40 mg or identical-appearing placebo for 12 weeks. Fasting lipid profiles and biochemical markers of bone formation (bone-specific alkaline phosphatase) and resorption (N-telopeptides and C-terminal propeptide of type 1 collagen) were measured at baseline, 6 and 12 weeks.
        
        
          Results
          Plasma low density lipoprotein-cholesterol concentration fell 7%, 39% (p < 0.01 vs baseline) and 47% (p < 0.01 vs baseline) after 12 weeks of treatment with placebo, simvastatin 20 mg and 40 mg, respectively. At baseline, bone marker concentrations were similar in the three treatment groups. At 6 and 12 weeks, bone marker concentrations were not different from baseline, and no significant differences in bone marker concentrations were observed between treatment groups at either 6 or 12 weeks.
        
        
          Conclusion
          Among osteopenic women, treatment with simvastatin for 12 weeks did not affect markers of bone formation or resorption.
Compound 527105: N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]-N-methylacetamide

Chemical compound data from PubChem database. IUPAC Name: N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]-N-methylacetamide. Molecular Formula: C19H19Cl2NO. Molecular Weight: 348.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Guidelines for conducting time-limited information technology demonstration  projects (pilots) in a Comprehensive Child Welfare Information System (CCWIS) environment

This Program Instruction (PI) provides state and tribal title IV-E agencies (agencies) guidance and describes the documentation requirements an agency must complete to maintain compliance with CCWIS requirements while evaluating new child welfare business processes, tools, or information technologies through pilots.

Metadata-only record linking to the original dataset. Open original dataset below.
Benefits and Cost Sharing PUF - PY2020

The Benefits and Cost Sharing PUF (BenCS-PUF) is one of the files that make up the Marketplace PUF. The BenCS-PUF contains plan-level data on essential health benefits, coverage limits, and cost sharing for each QHP and SADP. These data either originate from the Plans &amp; Benefits template (i.e., template field), an Excel-based form used by issuers to describe their plans in the QHP/SADP application process, or were generated by CCIIO for use in data processing (i.e., system-generated).
CDC STATE System Tobacco Legislation - Preemption Summary

1995-2024. Centers for Disease Control and Prevention (CDC). State Tobacco Activities Tracking and Evaluation (STATE) System. Legislation - Preemption. The STATE System houses current and historical state-level legislative data on tobacco use prevention and control policies. Data are reported on a quarterly basis. Data include information related to summary state preemption of more stringent or differing local laws on smokefree indoor air, youth access and licensure.
Patent AT-E401563-T1: [Translated] WASHING PROCEDURE FOR REMOVAL OF UNDESIRABLE COMPONENTS IN SAMPLES TO BE ANALYZED

A method for removing undesired component(s) from bound desired component(s) in an analysis including: (a) providing a container having a desired component bound thereto and an undesired component; (b) dispensing wash fluid in the container at a first level sufficient to contact a portion of the bound desired component; (c) oscillating wash fluid level in the container; and (d) removing a portion of the wash fluid from the container. A method for removing undesired components from bound desired components in an analysis including steps (a) and (b) above; (c) removing the wash fluid; (d) dispensing a wash fluid at a subsequent level lower than the first level and sufficient to wash the bound desired substrate; and (e) removing wash fluid. Preferably, the desired component is an analyte being measured. Another aspect of the invention provides a method for removing an undesired component from a bound desired component in an analysis by removing a surface portion of fluid containing a portion of the undesired component.
Validation and results of a questionnaire for functional bowel disease in out-patients

Background
          The aim was to evaluate and validate a bowel disease questionnaire in patients attending an out-patient gastroenterology clinic in Greece.
        
        
          Methods
          This was a prospective study. Diagnosis was based on detailed clinical and laboratory evaluation. The questionnaire was tested on a pilot group of patients. Interviewer-administration technique was used. One-hundred-and-forty consecutive patients attending the out-patient clinic for the first time and fifty healthy controls selected randomly participated in the study. Reliability (kappa statistics) and validity of the questionnaire were tested. We used logistic regression models and binary recursive partitioning for assessing distinguishing ability among irritable bowel syndrome (IBS), functional dyspepsia and organic disease patients.
        
        
          Results
          Mean time for questionnaire completion was 18 min. In test-retest procedure a good agreement was obtained (kappa statistics 0.82). There were 55 patients diagnosed as having IBS, 18 with functional dyspepsia (Rome I criteria), 38 with organic disease. Location of pain was a significant distinguishing factor, patients with functional dyspepsia having no lower abdominal pain (p < 0.001). Significant factors distinguishing between IBS and functional dyspepsia were relief of pain by either antacids or defecation (19% vs 71% and 66% vs 0% respectively). Awakening from pain at night was also a factor distinguishing between IBS and organic disease groups (26% vs 61%, p < 0.01).
        
        
          Conclusions
          This questionnaire for functional bowel disease is a valid and reliable instrument that can distinguish satisfactorily between organic and functional disease in an out-patient setting.
AFCARS Report #24

This report provides preliminary estimates of Adoption and Foster Care Analysis and Reporting System (AFCARS) data for FY 2016. As states are permitted to resubmit AFCARS data, the estimates may change over time. This report reflects all AFCARS data received as of October 20, 2017 related to AFCARS reporting periods through September 30, 2016.

Metadata-only record linking to the original dataset. Open original dataset below.
Georgia (GA)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Georgia for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.
Research Article: Genome Biology

Background
          Computational predictions are critical for directing the experimental study of protein functions. Therefore it is paradoxical when an apparently erroneous computational prediction seems to be supported by experiment.
        
        
          Results
          We analyzed six cases where application of novel or conventional computational methods for protein sequence and structure analysis led to non-trivial predictions that were subsequently supported by direct experiments. We show that, on all six occasions, the original prediction was unjustified, and in at least three cases, an alternative, well-supported computational prediction, incompatible with the original one, could be derived. The most unusual cases involved the identification of an archaeal cysteinyl-tRNA synthetase, a dihydropteroate synthase and a thymidylate synthase, for which experimental verifications of apparently erroneous computational predictions were reported. Using sequence-profile analysis, multiple alignment and secondary-structure prediction, we have identified the unique archaeal 'cysteinyl-tRNA synthetase' as a homolog of extracellular polygalactosaminidases, and the 'dihydropteroate synthase' as a member of the β-lactamase-like superfamily of metal-dependent hydrolases.
        
        
          Conclusions
          In each of the analyzed cases, the original computational predictions could be refuted and, in some instances, alternative strongly supported predictions were obtained. The nature of the experimental evidence that appears to support these predictions remains an open question. Some of these experiments might signify discovery of extremely unusual forms of the respective enzymes, whereas the results of others could be due to artifacts.
COVID-19 Reported Patient Impact and Hospital Capacity by State Timeseries

<p><b>After May 3, 2024, this dataset and webpage will no longer be updated because hospitals are no longer required to report data on COVID-19 hospital admissions, and hospital capacity and occupancy data, to HHS through CDC’s National Healthcare Safety Network. Data voluntarily reported to NHSN after May 1, 2024, will be available starting May 10, 2024, at <a href="https://covid.cdc.gov/covid-data-tracker/#hospitalizations-landing">COVID Data Tracker Hospitalizations</a>.</b></p>

<p>The following dataset provides state-aggregated data for hospital utilization <b>in a timeseries format</b> dating back to January 1, 2020. These are derived from reports with facility-level granularity across three main sources: (1) National Healthcare Safety Network (NHSN) (after December 15, 2022) (2) HHS TeleTracking (before December 15, 2022), (3) reporting provided directly to HHS Protect by state/territorial health departments on behalf of their healthcare facilities, and (4) historical NHSN timeseries data (before July 15, 2020). Data in this file have undergone routine data quality review of key variables of interest by subject matter experts to identify and correct obvious data entry errors. </p>

<p>The file will be updated regularly and provides the latest values reported by each facility within the last four days for all time. This allows for a more comprehensive picture of the hospital utilization within a state by ensuring a hospital is represented, even if they miss a single day of reporting.</p>

No statistical analysis is applied to account for non-response and/or to account for missing data.
<br><br>
The below table displays one value for each field (i.e., column). Sometimes, reports for a given facility will be provided to more than one reporting source: HHS TeleTracking, NHSN, and HHS Protect. When this occurs, to ensure that there are not duplicate reports, prioritization is applied to the numbers for each facility.
<br><br>
This file contains data that have been corrected based on additional data quality checks applied to select data elements. The resulting dataset allows various data consumers to use for their analyses a high-quality dataset with consistent standards of data processing and cleaning applied. 
 <br>
<p>
The following fields in this dataset are derived from data elements included in these data quality checks: 

<li>inpatient_beds 
<li>inpatient_beds_used
<li>total_staffed_adult_icu_beds 
<li>adult_icu_bed_utilization
<li>adult_icu_bed_utilization_numerator 
<li>adult_icu_bed_utilization_denominator
<li>adult_icu_bed_covid_utilization_numerator 
<li>adult_icu_bed_covid_utilization_denominator
<li>adult_icu_bed_covid_utilization
<li>total_adult_patients_hospitalized_confirmed_covid
<li>total_pediatric_patients_hospitalized_confirmed_covid
</p>
Using evidence from different sources: an example using paracetamol 1000 mg plus codeine 60 mg

Background
          Meta-analysis usually restricts the information pooled, for instance using only randomised, double-blind, placebo-controlled trials. This neglects other types of high quality information. This review explores using different information for the combination of paracetamol 1000 mg and codeine 60 mg in acute postoperative pain.
        
        
          Results
          Randomised, double-blind, placebo-controlled trials of paracetamol 1000 mg and codeine 60 mg had an NNT of 2.2 (95% confidence interval 1.7 to 2.9) for at least 50% pain relief over four to six hours in three trials with 197 patients. Computer simulation of randomised trials demonstrated 92% confidence that the simulated NNT was within ± 0.5 of the underlying value of 2.2 with this number of patients. The result was supported a rational dose-response relationship for different doses of paracetamol and codeine in 17 additional trials with 1,195 patients. Three controlled trials lacking a placebo and with 117 patients treated with of paracetamol 1000 mg and codeine 60 mg had 73% (95%CI 56% to 81%) of patients with at least 50% pain relief, compared with 57% (48% to 66%) in placebo controlled trials. Six trials in acute pain were omitted because of design issues, like the use of different pain measures or multiple dosing regimens. In each paracetamol 1000 mg and codeine 60 mg was shown to be better than placebo or comparators for at least one measure.
        
        
          Conclusions
          Different designs of high quality trials can be used to support limited information used in meta-analysis without recourse to low quality trials that might be biased.
Adoption Data 2008

This page includes reports on state-specific adoption statistics for fiscal year 2008.

Receiving Adoption Subsidy: 10/1/2007 - 9/30/2008
Adoptive Family Structure: 10/1/2007 - 9/30/2008
Age at Adoption Finalization: 10/1/2007 - 9/30/2008
Prior Relationship of Adoptive Parent(s) to Child: 10/1/2007 - 9/30/2008
Race/Ethnicity of Public Agency Children Adopted: 10/1/2007 - 9/30/2008
Sex of Public Agency Children Adopted: 10/1/2007 - 9/30/2008
Child is Identified as a Special Needs Adoption: 10/1/2007 - 9/30/2008
Time between Termination of Parental Rights (TPR) and Adoption Finalization: 10/1/2007 - 9/30/2008

Metadata-only record linking to the original dataset. Open original dataset below.
Patent AT-E400546-T1: [Translated] METHOD FOR PRODUCING TRIETHANOLAMINE

Methods for improving color properties of triethanolamine, and triethanolamine compositions treated thereby, are disclosed, wherein the methods comprise: (a) providing a composition comprising triethanolamine; and (b) contacting the composition with an acid component and a basic component; wherein the acid component comprises an acid selected from the group consisting of phosphorous acid, hypophosphorous acid and mixtures thereof; and wherein the basic component comprises a compound selected from the group consisting of alkali metal hydroxides, alkaline earth metal hydroxides, ammonium hydroxides according to general formula (I), and mixtures thereof: <?in-line-formulae description="In-line Formulae" end="lead"?>[R1R2R3(2-hydroxyethyl)ammonium] hydroxide (I)<?in-line-formulae description="In-line Formulae" end="tail"?> wherein R1, R2 and R3 each independently represents a C1-30 alkyl or a C2-10 hydroxyalkyl; with the proviso that where the basic component comprises an alkali metal hydroxide, the molar ratio of acid component: basic component is 1:0.1 to 1:1, and where the basic component comprises an alkaline earth metal hydroxide, the molar ratio of acid component: basic component is 1:0.05 to 1:0.5.
A successful pregnancy following SEM fine tuning of hormonal priming

Background
          Manipulation of the uterine epithelium utilising standard dose exogenous oestrogen (E2) and progesterone (P4) has been shown to achieve a mature secretory morphological response. However, in an in vitro fertilisation (IVF) setting, frozen embryo transfer (ET) has had a low success rate. We propose that in patients with previously failed ET attempts, the uterine epithelium can be directly visualised by biopsy and Scanning Electron Microscopy (SEM) and that with an individualised fine tuning of the hormone supplementation regime, based on the SEM examination of sequential uterine biopsies, it is possible to provide a uterine environment conducive to successful ET.
        
        
          Methods
          A 47 year old women was chosen for endometrial biopsy, histopathological dating and endometrial observation utilising SEM to determine the integrity of her secretory uterine epithelium because of her age and several previously failed attempts at frozen ET. Exogenous E2 and P4 supplementation was administered in modified doses according to the SEM result, in consecutive cycles until the epithelial response appeared satisfactory for potential implantation.
        
        
          Results
          This case study demonstrates the dramatic change in epithelial characteristics that can be achieved as a response to these altered doses of E2 and P4. The uterine morphology changed from a hypotrophic to a mature, receptive epithelium such that ET resulted in the birth of healthy twin boys.
        
        
          Conclusion
          The comparison between the consecutive biopsies in direct response to the SEM analysis and tailored modification of E2 and P4 dose clearly demonstrates, in this case, the effectiveness of individual morphological monitoring to maximise the successful outcome of ET.
Levonorgestrel and ethinyl estradiol

Tyblume is a prescription oral contraceptive containing levonorgestrel (0.1 mg) and ethinyl estradiol (0.02 mg) in tablet form. It's used to prevent pregnancy by regulating hormones. Manufactured by Exeltis USA, Inc., under NDA209405, it comes in blister packs. This information was generated using AI and is provided for informational and research purposes only.
Compound 529538: 2-Hept-6-enyl-3-octa-2,5-dienyloxirane

Chemical compound data from PubChem database. IUPAC Name: 2-hept-6-enyl-3-octa-2,5-dienyloxirane. Molecular Formula: C17H28O. Molecular Weight: 248.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Kentucky (KY)

This report presents Kentucky\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Kentucky for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.
Behavioral Risk Factor Surveillance Survey: 2018

The Behavioral Risk Factor Surveillance System (BRFSS) is an annual statewide telephone surveillance system designed by the Centers for Disease Control and Prevention (CDC). BRFSS monitors modifiable risk behaviors and other factors contributing to the leading causes of morbidity and mortality in the population. New York State's BRFSS sample represents the non-institutionalized adult household population, aged 18 years and older. Although the overall number of respondents in the BRFSS is more than sufficiently large for statistical inference purposes, subgroup analyses can lead to estimates that are unreliable. Interpreting and reporting weighted numbers that are based on a small, unweighted number of respondents can mislead the reader into believing that a given finding is much more precise than it actually is. The BRFSS follows a rule of not reporting or interpreting percentages based upon a denominator of fewer than 50 respondents (unweighted sample). Both a csv and sas data files are available. For more information, check out http://www.health.ny.gov/statistics/brfss/.