AndreaBozzo/ceres-open-data-index huggingface dataset:
Results from the 2011 National Survey on Drug Use and Health: Summary of National Findings

This report presents results from the 2011 National Survey on Drug Use and Health (NSDUH). The report includes national estimates of rates of initiation and use of illicit drugs (e.g., marijuana, cocaine, heroin, hallucinogens, inhalants, and the nonmedical use of prescription-type pain relievers, tranquilizers, stimulants, and sedatives), alcohol, and tobacco products and rates of driving under the influence of drugs or alcohol. The report also covers substance use treatment need/receipt and youth risk and prevention measures. Results are provided for age group, gender, pregnancy status, race/ethnicity, education level, employment status, geographic area, parole/probation status. Comparisons are made between 2011 and 2002 to 2010.
Genetic transformation of

Background
          Efficient transformation and regeneration methods are a priority for successful application of genetic engineering to vegetative propagated plants such as grape. The current methods for the production of transgenic grape plants are based on Agrobacterium-mediated transformation followed by regeneration from embryogenic callus. However, grape embryogenic calli are laborious to establish and the phenotype of the regenerated plants can be  altered.
        
        
          Results
          Transgenic grape plants (V. vinifera, table-grape cultivars Silcora and Thompson Seedless) were produced using a method based on regeneration via organogenesis. In vitro proliferating shoots were cultured in the presence of increasing concentrations of N6-benzyl adenine. The apical dome of the shoot was removed at each transplantation which, after three months, produced meristematic bulk tissue characterized by a strong capacity to differentiate adventitious shoots. Slices prepared from the meristematic bulk were used for Agrobacterium-mediated transformation of grape plants with the gene DefH9-iaaM. After rooting on kanamycin containing media and greenhouse acclimatization, transgenic plants were transferred to the field. At the end of the first year of field cultivation, DefH9-iaaM grape plants were phenotypically homogeneous and did not show any morphological alterations in vegetative growth. The expression of DefH9-iaaM gene was detected in transgenic flower buds of both cultivars.
        
        
          Conclusions
          The phenotypic homogeneity of the regenerated plants highlights the validity of this method for both propagation and genetic transformation of table grape cultivars. Expression of the DefH9-iaaM gene takes place in young flower buds of transgenic plants from both grape cultivars.
Compound 530012: Hexadecane, 7-methyl-6-pentyl

Chemical compound data from PubChem database. IUPAC Name: 7-methyl-6-pentylhexadecane. Molecular Formula: C22H46. Molecular Weight: 310.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
The regulation of CD5 expression in murine T cells

Background
          CD5 is a pan-T cell surface marker that is also present on a subset of B cells, B-1a cells.Functional and developmental subsets of T cells express characteristic CD5 levels that vary over roughly a 30-fold range. Previous investigators have cloned a 1.7 Kb fragment containing the CD5 promoter and showed that it can confer similar lymphocyte-specific expression pattern as observed for endogenous CD5 expression.
        
        
          Results
          We further characterize the CD5 promoter and identify minimal and regulatory regions on the CD5 promoter. Using a luciferase reporter system, we show that a 43 bp region on the CD5 promoter regulates CD5 expression in resting mouse thymoma EL4 T cells and that an Ets binding site within the 43 bp region mediates the CD5 expression. In addition, we show that Ets-1, a member of the Ets family of transcription factors, recognizes the Ets binding site in the electrophoretic mobility shift assay (EMSA). This Ets binding site is directly responsible for the increase in reporter activity when co-transfected with increasing amounts of Ets-1 expression plasmid.
          We also identify two additional evolutionarily-conserved regions in the CD5 promoter (CD5X and CD5Y) and demonstrate the respective roles of the each region in the regulation of CD5 transcription.
        
        
          Conclusion
          Our studies define a minimal and regulatory promoter for CD5 and show that the CD5 expression level in T cells is at least partially dependent on the level of Ets-1 protein. Based on the findings in this report, we propose a model of CD5 transcriptional regulation in T cells.
Immunodetection of nmt55/p54

Background
          We previously identified and characterized a novel 55 kDa nuclear protein, termed nmt55/p54nrb, whose expression was decreased in a subset of human breast tumors. The objective of this study was to determine if this reduced expression in human breast tumors was attributed to the regulation of mRNA transcription or the presence of altered forms of this protein.
        
        
          Results
          Northern blot analysis and ribonuclease protection assay indicated that nmt55/p54nrb mRNA is expressed at varying levels in estrogen receptor positive (ER+) and estrogen receptor negative (ER-) human breast tumors suggesting that reduced expression of nmt55/p54nrb protein in ER- tumors was not due to transcriptional regulation. To determine if multiple protein isoforms are expressed in breast cancer, we utilized Western blot and immunohistochemical analyses, which revealed the expression of an nmt55/p54nrb protein isoform in a subset of ER+ tumors. This subset of ER+ human breast tumors expressed an altered form of nmt55/p54nrb that was undetectable with an amino-terminal specific antibody suggesting that this isoform contains alterations or modifications within the amino terminal domain.
        
        
          Conclusions
          Our study indicates that nmt55/p54nrb protein is post-transcriptionally regulated in human breast tumors leading to reduced expression in ER- tumors and the expression of an amino terminal altered isoform in a subset of ER+ tumors. The potential involvement of nmt55/p54nrb in RNA binding and pre-mRNA splicing may be important for normal cell growth and function; thus, loss or alteration of protein structure may contribute to tumor growth and progression.
Modeling of failure mode in knee ligaments depending on the strain rate

Background
          The failure mechanism of the knee ligament (bone-ligament-bone complex) at different strain rates is an important subject in the biomechanics of the knee. This study reviews and summarizes the literature describing ligament injury as a function of stain rate, which has been published during the last 30 years.
        
        
          Methods
          Three modes of injury are presented as a function of strain rate, and they are used to analyze the published cases. The number of avulsions is larger than that of ligament tearing in mode I. There is no significant difference between the number of avulsions and ligament tearing in mode II. Ligament tearing happens more frequently than avulsion in mode III.
        
        
          Results
          When the strain rate increases, the order of mode is mode I, II, III, I, and II. Analytical models of ligament behavior as a function of strain rate are also presented and used to provide an integrated framework for describing all of the failure regimes. In addition, this study showed the failure mechanisms with different specimens, ages, and strain rates.
        
        
          Conclusion
          There have been several a numbers of studies of ligament failure under various conditions including widely varying strain rates. One issue in these studies is whether ligament failure occurs mid-ligament or at the bone attachment point, with assertions that this is a function of the strain rate. However, over the range of strain rates and other conditions reported, there has appeared to be discrepancies in the conclusions on the effect of strain rate. The analysis and model presented here provides a unifying assessment of the previous disparities, emphasizing the differential effect of strain rate on the relative strengths of the ligament and the attachment.
Compound 530517: 5-Bromovaleric acid, tetradecyl ester

Chemical compound data from PubChem database. IUPAC Name: tetradecyl 5-bromopentanoate. Molecular Formula: C19H37BrO2. Molecular Weight: 377.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
COVID-19 Vaccination Age and Sex Trends in the United States, National and Jurisdictional

This site provides data for select demographic characteristics (age, sex, and age by sex) of people receiving COVID-19 vaccinations in the United States at the national and jurisdictional levels. For national race/ethnicity data, please visit <a href="https://data.cdc.gov/Vaccinations/COVID-19-Vaccination-Demographics-in-the-United-St/km4m-vcsb">COVID-19 Vaccination Demographics in the United States,National</a>. For jurisdictional race/ethnicity data, please visit the relevant health department website if available.
 
Data represents all vaccine partners including jurisdictional partner clinics, retail pharmacies, long-term care facilities, dialysis centers, Federal Emergency Management Agency and Health Resources and Services Administration partner sites, and federal entity facilities.
Recruitment curve of the soleus H-reflex in chronic back pain and lumbosacral radiculopathy

Background
          Needle EMG may be negative in mild or predominantly sensory lumbosacral radiculopathies. In such cases, an increase in the latency of the soleus H-reflex is a useful diagnostic criterion for establishing sensory fiber compromise at the S1 root level. However, if clinical signs of radicular involvement are lacking, the latency of the H-reflex is normal. We therefore studied the recruitment curve of the soleus H-reflex to investigate whether a change in the electrical threshold for eliciting the H-reflex might be a more sensitive criterion for detecting subclinical S1 root dysfunction.
        
        
          Methods
          Clinical and electrophysiological findings from 26 patients with chronic back pain and radiculopathy were compared with data obtained from 40 healthy subjects.
        
        
          Results
          An increase in the mean H-reflex threshold was the only abnormal electrophysiological finding in patients with no clinical sign of root injury (58%). A decrease in the mean H-reflex amplitude and a prolongation of H-reflex latency was observed in patients with radicular signs (42%). In both patients groups, F-wave and needle EMG studies were normal. No radiological evidence of S1 root compression was found.
        
        
          Conclusions
          The study of the recruitment curve of the soleus H-reflex may be usefully associated to F-wave and needle EMG studies to detect possible S1 root dysfunction in mild lumbosacral radiculopathies. An increase in H-threshold may be the earliest abnormality in the absence of focal neurological signs.
Compound 529783: Propanoic acid, 3,5-bis-(trifluoromethyl)phenylmethyl ester

Chemical compound data from PubChem database. IUPAC Name: [3,5-bis(trifluoromethyl)phenyl]methyl propanoate. Molecular Formula: C12H10F6O2. Molecular Weight: 300.2. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Examination of the exposome in an animal model: the impact of high fat diet and rat strain on local and systemic immune markers following occupational welding fume exposure

The fundamental goal of this study was to develop an in vivo model of the exposome that could be used to evaluate exposure-induced alterations in local and systemic immune markers as a function of various exposomal factors. Accordingly, the model was designed to mimic an occupationally-relevant scenario in which inhalation of welding fumes (WF) constituted the primary occupational/environmental exposure of interest. Immune endpoints were assessed at three different time points representative of different stages in the exposure/response timeline (before WF exposure, directly after, and following a 12 wk recovery period). Moreover, the potential impact of genetic variation and lifestyle factors on the immune response to WF exposure and subsequent recovery was addressed by incorporating two different rat strains (Sprague-Dawley [SD] and Brown Norway [BN]) and two variations in diet (regular and high fat) into the model.

One of the primary objectives of this study was to determine whether consumption of a HF diet is associated with increased immunological responsivity following exposure to a common respiratory toxicant. The study was also executed with the goal of identifying which experimental factor (genetics/strain, diet, occupational exposure) is most influential in the modulation of local and systemic markers of immune status following WF exposure, and subsequently, the efficacy of inflammation resolution. The information obtained from these analyses will help elucidate which exposomic determinants may be particularly relevant in the context of immunotoxicity, and accordingly, warrant special attention in future investigations. The results will also contribute to the development of other in vivo exposome models and direct future efforts related to the exposome and its impact on human health.
COVID-19 Updated Vaccines Distributed

This site provides historical data beginning June 14, 2023, for the visualization presented on <a href="https://covid.cdc.gov/covid-data-tracker/#vaccinations">COVID-19 Data Tracker’s “Vaccinations in the United States" </a> site titled “US COVID-19 Vaccine Doses Delivered by Vaccine Type”

<b>Definition for Distributed: </b>
Cumulative number of COVID-19 updated vaccine doses distributed in the United States.
CDC is no longer reporting metrics for Johnson & Johnson, and the original Pfizer and Moderna vaccines.

Data represents all vaccine partners including jurisdictional partner clinics, retail pharmacies, long-term care facilities, dialysis centers, Federal Emergency Management Agency and Health Resources and Services Administration partner sites, and federal entity facilities.
Compound 525108: 2,3-Dichloropropyl isobutyrate

Chemical compound data from PubChem database. IUPAC Name: 2,3-dichloropropyl 2-methylpropanoate. Molecular Formula: C7H12Cl2O2. Molecular Weight: 199.07. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Gallup Poll: Child Abuse Study, 1995

A nationwide random telephone survey of 1,000 households was conducted between August 15 and September 14,1995. The survey assessed parental attitudes regarding methods of discipline; agreement on discipline; fights between partners; child rearing; and childhood experience of punishment, abuse between parents, and sexual abuse.  This survey represents the first national study assessing the validity and reliability of the Parent-Child version of the Conflict Tactics Scale as developed by Straus et al. The maximum margin of error for the survey was +/- 3 percentage points.

Investigators: Gallup Poll News Service
A simple method to assess the oxidative susceptibility of low density lipoproteins

Background
          Oxidative modification of low density lipoproteins (LDL) is recognized as one of the major processes involved in atherogenesis. The in vitro standardized measurement of LDL oxidative susceptibility could thus be of clinical significance. The aim of the present study was to establish a method which would allow the evaluation of oxidative susceptibility of LDL in the general clinical laboratory.
        
        
          Results
          LDL was isolated from human plasma by selective precipitation with amphipathic polymers. The ability of LDL to form peroxides was assessed by measuring thiobarbituric acid reactive substances (TBARS) after incubation with Cu2+ and H2O2. Reaction kinetics showed a three-phase pattern (latency, propagation and decomposition phases) which allowed us to select 150 min as the time point to stop the incubation by cooling and EDTA addition. The mixture Cu2+/H2O2 yielded more lipoperoxides than each one on its own at the same time end-point. Induced peroxidation was measured in normal subjects and in type 2 diabetic patients. In the control group, results were 21.7 ± 1.5 nmol MDA/mg LDL protein, while in the diabetic group results were significantly increased (39.0 ± 3.0 nmol MDA/mg LDL protein; p < 0.001).
        
        
          Conclusion
          a simple and useful method is presented for the routine determination of LDL susceptibility to peroxidation in a clinical laboratory.
Patent AT-E401833-T1: [Translated] ENOSSAL IMPLANT AND METHOD FOR PRODUCTION

Implant comprises a peripheral collar (4) formed in the corner region of the distal end of the implant core (1). An independent claim is also included for a process for the production of the implant. Preferred Features: The collar is arranged below an angle alpha to the implantation axis and is diameter (D) is matched to the final outer contour of the implant. Cut-outs are arranged in the contour of the collar. The collar has a closed ring contour.
Distinct functions of

Background
          In most organisms proper reductional chromosome segregation during meiosis I is strongly correlated with the presence of crossover recombination structures (chiasmata); recombination deficient mutants lack crossovers and suffer meiosis I nondisjunction. We report that these functions are separable in the fission yeast Schizosaccharomyces pombe.
        
        
          Results
          Intron mapping and expression studies confirmed that Rec12 is a member of the Spo11/Top6A topoisomerase family required for the formation of meiotic dsDNA breaks and recombination. rec12-117, rec12-D15 (null), and rec12-Y98F (active site) mutants lacked most crossover recombination and chromosomes segregated abnormally to generate aneuploid meiotic products. Since S. pombe contains only three chromosome pairs, many of those aneuploid products were viable. The types of aberrant chromosome segregation were inferred from the inheritance patterns of centromere linked markers in diploid meiotic products. The rec12-117 and rec12-D15 mutants manifest segregation errors during both meiosis I and meiosis II. Remarkably, the rec12-Y98F (active site) mutant exhibited essentially normal meiosis I segregation patterns, but still exhibited meiosis II segregation errors.
        
        
          Conclusions
          Rec12 is a 345 amino acid protein required for most crossover recombination and for chiasmatic segregation of chromosomes during meiosis I. Rec12 also participates in a backup distributive (achiasmatic) system of chromosome segregation during meiosis I. In addition, catalytically-active Rec12 mediates some signal that is required for faithful equational segregation of chromosomes during meiosis II.
Compound 525821: N-Phenyl-N'-(4-methoxyphenyl)formamidine

Chemical compound data from PubChem database. IUPAC Name: N'-(4-methoxyphenyl)-N-phenylmethanimidamide. Molecular Formula: C14H14N2O. Molecular Weight: 226.27. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528855: 1-(Methylthioethyl) methyl disulfide

Chemical compound data from PubChem database. IUPAC Name: 1-(methyldisulfanyl)-1-methylsulfanylethane. Molecular Formula: C4H10S3. Molecular Weight: 154.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Localities for 2008B

The Medicare Improvements for Patients and Providers Act of 2008 was enacted on July 15, 2008. As a result, the mid-year 2008 Medicare Physician Fee Schedule (MPFS) rate of -10.6 percent was replaced with a 0.5 percent update, retroactive to July 1, 2008. In the year dropdown box above, select "2008A" for fees effective January 1, 2008 through June 30, 2008 and select "2008B" for fees effective July 1, 2008 through December 31, 2008.
Program Instruction (PI-16-03)

This Program Instruction (PI) provides guidance to states, territories, and insular areas (hereafter “states,” unless otherwise noted) on actions they are required to take to receive their allotments for federal fiscal year (FY) 2017 (subject to the availability of appropriations) authorized under title IV-B, subparts 1 and 2, section 106 of CAPTA, CFCIP and ETV programs.

PI-16-03 (PDF)

Fiscal Year 2016 Allotment Title IV-B Subpart 1 Stephanie Tubbs Jones Child Welfare Services
Fiscal Year 2016 Allotment Title IV-B Subpart 2 Promoting Safe and Stable Families
Fiscal Year 2016 Allotment for Title IV-B, Subpart 2 Monthly Caseworker Visit Funds
Fiscal Year 2016 Allotment for CAPTA
Fiscal Year 2016 Allotment for Chafee Foster Care Independence Program
Fiscal Year 2016 Allotment for Education and Training Vouchers

CFS-101 Part I:  Annual Budget Request for Title IV-B, subparts 1 and 2, CAPTA, Chafee Foster Care Independence (CFCIP) and Education and Training Voucher (ETV) Program Instructions
CFS-101 Part I:  Annual Budget Request for Title IV-B, subparts 1 and 2, CAPTA, Chafee Foster Care Independence (CFCIP) and Education and Training Voucher (ETV) Program Form (Excel (XLSX) - 13 KB)
CFS-101, Part II:  Annual Summary of Child and Family Services Instructions
CFS-101, Part II:  Annual Summary of Child and Family Services Form (Excel (XLSX) - 13 KB)
CFS-101, Part III:  Annual Expenditures for Title IV-B, subparts 1 and 2, CAPTA, Chafee Foster Care Independence (CFCIP) and Education and Training Voucher (ETV) Instructions
CFS-101, Part III:  Annual Expenditures for Title IV-B, subparts 1 and 2, CAPTA, Chafee Foster Care Independence (CFCIP) and Education and Training Voucher (ETV) Form (Excel (XLSX) - 12 KB)

CB Regional Program Managers

NCANDS State Contact List

Annual Reporting of Education and Training Vouchers Awarded (Word (DOCX) - 22 KB)

CAPTA State Plan Assurances (Word (DOCX) - 24 KB)

Metadata-only record linking to the original dataset. Open original dataset below.
Decreases in blood perfusion of the anterior cingulate gyri in Anorexia Nervosa Restricters assessed by SPECT image analysis

Background
          It is possible that psychopathological differences exist between the restricting and bulimic forms of anorexia nervosa. We investigated localized differences of brain blood flow of anorexia nervosa patients using SPECT image analysis with statistic parametric mapping (SPM) in an attempt to link brain blood flow patterns to neurophysiologic characteristics.
        
        
          Methods
          The subjects enrolled in this study included the following three groups: pure restrictor anorexics (AN-R), anorexic bulimics (AN-BP), and healthy volunteers (HV). All images were transformed into the standard anatomical space of the stereotactic brain atlas, then smoothed. After statistical analysis of each brain image, the relationships among images were evaluated.
        
        
          Results
          SPM analysis of the SPECT images revealed that the blood flow of frontal area mainly containing bilateral anterior cingulate gyri (ACC) was significantly decreased in the AN-R group compared to the AN-BP and HV groups.
        
        
          Conclusions
          These findings suggest that some localized functions ofthe ACCare possibly relevant to the psychopathological aspects of AN-R.