AndreaBozzo/ceres-open-data-index huggingface dataset:
Types of inter-atomic interactions at the MHC-peptide interface: Identifying commonality from accumulated data

Background
          Quantitative information on the types of inter-atomic interactions at the MHC-peptide interface will provide insights to backbone/sidechain atom preference during binding. Qualitative descriptions of such interactions in each complex have been documented by protein crystallographers. However, no comprehensive report is available to account for the common types of inter-atomic interactions in a set of MHC-peptide complexes characterized by variation in MHC allele and peptide sequence. The available x-ray crystallography data for these complexes in the Protein Databank (PDB) provides an opportunity to identify the prevalent types of such interactions at the binding interface.
        
        
          Results
          We calculated the percentage distributions of four types of interactions at varying inter-atomic distances. The mean percentage distribution for these interactions and their standard deviation about the mean distribution is presented. The prevalence of SS and SB interactions at the MHC-peptide interface is shown in this study. SB is clearly dominant at an inter-atomic distance of 3Å.
        
        
          Conclusion
          The prevalently dominant SB interactions at the interface suggest the importance of peptide backbone conformation during MHC-peptide binding. Currently, available algorithms are developed for protein sidechain prediction upon fixed backbone template. This study shows the preference of backbone atoms in MHC-peptide binding and hence emphasizes the need for accurate peptide backbone prediction in quantitative MHC-peptide binding calculations.
Biological effects of inhaled crude oil vapor VI. Altered biogenic amine neurotransmitters and neural protein expression

In the oil and gas industry, workers are potentially exposed to crude oil or crude oil vapor (COV) during upstream (drilling and extraction), midstream (transportation and storage), as well as downstream (refining) activities.  Worker exposure to various fractions of crude oil have been linked to mortality, as well as musculoskeletal, respiratory, gastrointestinal, circulatory problems, and cancer.  During the Gulf of Mexico Deepwater Horizon (DWH) oil spill, response workers were exposed to a variety of chemical hazards including volatile organic compounds (VOCs), polycyclic aromatic hydrocarbons (PAHs), heavy metals, as well as components of the oil dispersants employed to disperse the oil.  The Gulf Long-term Follow-up (GuLF) STUDY had reported that workers involved in the cleanup operations experienced adverse hematologic, pulmonary, hepatic, and cardiac problems.  However, long-term neurological effects remain unknown.

Health Hazard Evaluation (HHE) surveys conducted by NIOSH among the cleanup workers identified a variety of health effects, including neurological symptoms.  Unfortunately, as a significant number of response workers who experienced health symptoms were exposed to both crude oil and the oil dispersant that was aerially sprayed to the contain the spill, the health effects of crude oil exposures alone were difficult to discern from these surveys.  It is here that laboratory-based studies are advantageous as they can provide ample health risk information to establish the toxicological potential of the various chemical hazards at the workplace.  To that end, the present work evaluated the neurotoxic risks of COV generated from the Macondo well crude oil that was used as a surrogate for the DWH crude oil.
Patent AT-E400122-T1: [Translated] TUNNELING INTERNET PROTOCOL PACKETS BETWEEN A GATEWAY SUPPORT NODE AND A MOBILE TERMINAL

A telecommunications system comprises a user equipment operable to request a bearer for communicating internet protocol data according to the second internet protocol (IPv4) to and from a gateway support node of a packet radio network. The gateway support node is operable to establish a tunnelling protocol bearer for communicating the internet packet data to and from the user equipment across the packet data network. The user equipment is operable in combination with the gateway support node to form a link local address. The link local address comprises an interface identifier including a tunnelling end identifier of the tunnelling protocol bearer which ends at a gateway support node of the core network part of the packet radio network. An internet protocol address according to the first internet protocol is requested from an address allocation server using the link local address. The user equipment is operable in combination with the gateway support node to receive an allocated internet protocol address according to the first internet protocol, and to communicate with the user equipment using the allocated internet protocol address. Embodiments of the present invention provide a facility for generating a link local address, which can be routed according to the first internet protocol to a server. As such the link local address can be used to acquire an internet protocol address from an address allocation server according to the first internet protocol. The acquired address can therefore be used to communicate internet protocol data, replacing the link local address with the acquired address of the user equipment.
Clobetasol propionate cream usp, 0.05%

Clobetasol Propionate Cream USP, 0.05% is a prescription topical medication containing the corticosteroid clobetasol propionate. It's used to treat inflammatory skin conditions like eczema, psoriasis, and dermatitis by reducing redness, itching, and swelling. Apply a thin layer to affected areas as directed by a doctor. This information was generated using AI and is provided for informational and research purposes only.
Patent AT-E401571-T1: [Translated] MONITORING THE CONDITION OF A FLUID

The present invention is a compact apparatus and method that provides an efficient manner for monitoring the condition and level of a functional fluid directly in operating equipment. A sensor device is provided that includes a plurality of liquid sensors and a plurality of vapor sensors that when used in conjunction with one another at different temperatures, can provide a thorough evaluation of the oxidative degradation, liquid contamination and solid contamination of the fluid to detect the end of the useful life of the fluid. By providing liquid sensors and vapor sensors on the same device, the present invention allows for a compact, efficient, and economically feasible manner to monitor the condition of fluid as well as detecting abnormal operating conditions prior to further component damage and eventual equipment failure.
Hospital Inpatient Discharges (SPARCS De-Identified): 2021

The Statewide Planning and Research Cooperative System (SPARCS) Inpatient De-identified File contains discharge level detail on patient characteristics, diagnoses, treatments, services, and charges. This data file contains basic record level detail for the discharge. The de-identified data file does not contain data that is protected health information (PHI) under HIPAA. The health information is not individually identifiable; all data elements considered identifiable have been redacted. For example, the direct identifiers regarding a date have the day and month portion of the date removed.

Note: The full dataset may be downloaded in a smaller, compressed file format from the attachments section.
Compound 525602: N,N-Dimethyl-N'-(4-methylphenyl)-benzamidine

Chemical compound data from PubChem database. IUPAC Name: N,N-dimethyl-N'-(4-methylphenyl)benzenecarboximidamide. Molecular Formula: C16H18N2. Molecular Weight: 238.33. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 530366: 4-Hydroxy-3-methoxyphenethylene glycol triTMS

Chemical compound data from PubChem database. IUPAC Name: [4-[1,2-bis(trimethylsilyloxy)ethyl]-2-methoxyphenoxy]-trimethylsilane. Molecular Formula: C18H36O4Si3. Molecular Weight: 400.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Treatment Episode Data Set: Discharges (TEDS-D-2010)

<p>The Treatment Episode Data Set -- Discharges (TEDS-D) is a national census data system of annual discharges from substance abuse treatment facilities. TEDS-D provides annual data on the number and characteristics of persons discharged from public and private substance abuse treatment programs that receive public funding. Data collected both at admission and at discharge is included. The unit of analysis is a treatment discharge. TEDS-D consists of data reported to state substance abuse agencies by the treatment programs, which in turn report it to SAMHSA.<br />
A sister data system, called the Treatment Episode Data Set -- Admissions (TEDS-A), collects data on admissions to substance abuse treatment facilities. The first year of TEDS-A data is 1992, while the first year of TEDS-D is 2006.<br />
TEDS-D variables that are required to be reported are called the "Minimum Data Set (MDS)", while those that are optional are called the "Supplemental Data Set (SuDS)".<br />
Variables unique to TEDS-D, and not part of TEDS-A, are the length of stay, reason for leaving treatment, and service setting at time of discharge. TEDS-D also provides many of the same variables that exist in TEDS-A. This includes information on service setting, number of prior treatments, primary source of referral, sex, race, ethnicity, education, employment status, substance(s) abused, route of administration, frequency of use, age at first use, and whether methadone was prescribed in treatment. Supplemental variables include: diagnosis codes, presence of psychiatric problems, living arrangements, source of income, health insurance, expected source of payment, pregnancy and veteran status, marital status, detailed not in labor force codes, detailed criminal justice referral codes, days waiting to enter treatment, and the number of arrests in the 30 days prior to admissions (starting in 2008).<br />
Substances abused include alcohol, cocaine and crack, marijuana and<br />
hashish, heroin, nonprescription methadone, other opiates and<br />
synthetics, PCP, other hallucinogens, methamphetamine, other amphetamines,<br />
other stimulants, benzodiazepines, other non-benzodiazepine tranquilizers, barbiturates, other non-barbiturate sedatives or hypnotics, inhalants, over-the-counter medications, and other substances.<br />
Created variables include total number of substances reported, intravenous drug use (IDU), and flags for any mention of specific substances.This study has 1 Data Set.</p>
Compound 527059: 4-(3-Oxo-1-butynyl)-3,5,5-trimethylcyclohex-2-en-1-one

Chemical compound data from PubChem database. IUPAC Name: 3,5,5-trimethyl-4-(3-oxobut-1-ynyl)cyclohex-2-en-1-one. Molecular Formula: C13H16O2. Molecular Weight: 204.26. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Managed Care Individual Provider Network Data: June 30, 2013

The primary purpose for the Provider Network Data System is to collect data needed to evaluate the provider networks including physicians, hospitals, labs, home health agencies, durable medical equipment providers, etc., for all types of Managed Care plans in New York State, including HIV Special Need Plans (SNP), Family Health Plus (FHP) Buy-In, Programs of All-Inclusive Care for the Elderly (PACE), and Non-PACE Managed Long-Term Care (MLTC) plans. This dataset reflects individual provider data. Provider Network Data System information is self-reported. For more information, check out http://www.health.ny.gov/health_care/managed_care/.
Compound 526340: 2,9-Dibromo-1,3,6,8-tetrachloro-dibenzo-p-dioxin

Chemical compound data from PubChem database. IUPAC Name: 2,9-dibromo-1,3,6,8-tetrachlorodibenzo-p-dioxin. Molecular Formula: C12H2Br2Cl4O2. Molecular Weight: 479.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 530758: 2,6-Difluorobenzoic acid, 2-methylphenyl ester

Chemical compound data from PubChem database. IUPAC Name: (2-methylphenyl) 2,6-difluorobenzoate. Molecular Formula: C14H10F2O2. Molecular Weight: 248.22. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 525480: 4-Methyl-3-thia-1-hexene

Chemical compound data from PubChem database. IUPAC Name: 2-ethenylsulfanylbutane. Molecular Formula: C6H12S. Molecular Weight: 116.23. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E399643-T1: [Translated] COMPOUND SHAFT FOR PRESSURE CYLINDERS WITH HYDRAULIC SLEEVE FASTENING DEVICE

SUMARY   Comprises first and second pieces (10, 20) which have end configurations (11, 21) for installation and guide and respective coupling configurations (14, 24) plug-in fit at the ends of a third, tubular piece (30) which defines an intermediate, cylindrical section (31), for attachment of liners (40). The hydraulic device comprises two expansible sleeves (50) situated on the first and second pieces (10, 20) each with a circular cavity (51) connected to a longitudinal duct through the shaft containing a fluid capable of being subjected to pressure to make convex an external, deformable wall (52) of the sleeve. The longitudinal duct comprises first and second sections (12, 22) in the first and second pieces (10, 20) connected, by means of a flexible tube (60) located in the hollow interior of the third piece (30).
2010 CMHS Uniform Reporting System (URS) Output Tables for North Carolina

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
The International Sepsis Forum's controversies in sepsis: corticosteroids should be used to treat septic shock

The use of corticosteroids in septic shock remains controversial. It has been demonstrated that high doses of steroids (30 mg/kg methylprednisolone) for short periods of time are not beneficial. More recent studies using smaller doses (200–300 mg/day hydrocortisone) for longer periods of time have shown beneficial effects. These positive effects have included reversal of shock, trends toward decreased organ system dysfunction and decreased mortality. Based on the high proportion of patients who have relative adrenal insufficiency, the benefits of low doses of steroids and the minimal risks, steroids should be used to treat septic shock.
Compound 528038: 1,4,6-Octatriene, 2,7-dimethyl-, (E)-

Chemical compound data from PubChem database. IUPAC Name: 2,7-dimethylocta-1,4,6-triene. Molecular Formula: C10H16. Molecular Weight: 136.23. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Chicago: Drug-Related Emergency Department Visits, 2004-2011 - Suicide Attempts

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving suicide attempts in the Chicago metropolitan area, covering 2004-2011.  Drug-related suicide attempts include visits for drug overdoses and for suicide attempts by other means (e.g., using a firearm) if drugs were involved or related to the suicide attempt.
Compound 526996: 2-Ethyl-4-pent-2-enyl-1,3-dioxane

Chemical compound data from PubChem database. IUPAC Name: 2-ethyl-4-pent-2-enyl-1,3-dioxane. Molecular Formula: C11H20O2. Molecular Weight: 184.27. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
2020 NSDUH Annual National Report

Read key findings from the 2020 National Survey on Drug Use and Health (NSDUH) on substance use, mental health, and treatment by age group. Metrics in the report cover the civilian, noninstitutionalized US population ages 12 and older. Unlike other NSDUH Annual National Reports, the 2020 report has no comparisons to the previous year, because changes in survey methodology mean the indicators are not comparable to past NSDUH estimates.Along with the full report, a set of slides is available that displays figures from the report. An errata document with corrected information was added in January 2023.
Localities for 2015A

For January 1, 2015 through March 31, 2015, the PFS update was set at 0.0 percent by the Protecting Access to Medicare Act. After applying the budget neutrality adjustment of 0.9981, the conversion factor for January 1, 2015, through March 31, 2015 is $35.7547. Under the provisions of current law regarding the SGR, the conversion factor will change to $28.1872 on April 1, 2015 in the absence of Congressional action. In addition, the geographic practice cost index work floor of 1.0 expires on March 31, 2015 in the absence of legislative action.
Total Product Life Cycle (TPLC)

The Total Product Life Cycle (TPLC) database integrates premarket and postmarket data about medical devices. It includes information pulled from CDRH databases including Premarket Approvals (PMA), Premarket Notifications (510[k]), Adverse Events, and Recalls. You can search the TPLC database by device name or procode to receive a full report about a particular product line.
Compound 528985: 1,2-Tetracosanediol, di-TMS

Chemical compound data from PubChem database. IUPAC Name: trimethyl(1-trimethylsilyloxytetracosan-2-yloxy)silane. Molecular Formula: C30H66O2Si2. Molecular Weight: 515.0. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E400313-T1: [Translated] IMPROVED DRY POWDER INHALATION SYSTEM

The present invention relates to a pharmaceutical composition for inhalation, consisting in a combination of (A) a dry powder formulation containing a micronized active ingredient, alone or mixed with an inactive ingredient, said powder being filled in a hydroxypropylmethylcellulose (HPMC) capsule and (B) a single dose dry powder inhaler device especially adapted to said capsule to provide a high respiratory dose of said active ingredient when said drug is inhaled by the mouth through said device. Said device being characterized in that he is equipped with piercing needles or pins (in order to pierce the capsule) of diameter of not less than 0.8 mm preferably not less than 1 mm.
Compound 526487: 3-Mercapto-3-methylbutyl formate

Chemical compound data from PubChem database. IUPAC Name: (3-methyl-3-sulfanylbutyl) formate. Molecular Formula: C6H12O2S. Molecular Weight: 148.23. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Exposure to the immunomodulatory chemical triclosan differentially impacts immune cell populations in the skin of haired (BALB/c) and hairless (SKH1) mice

Workers across every occupational sector have the potential to be exposed to a wide variety of chemicals, and the skin is a primary route of exposure. Furthermore, exposure to certain chemicals has been linked to inflammatory and allergic diseases. Thus, understanding the immune responses to chemical exposures on the skin and the potential for inflammation and sensitization is needed to improve worker safety and health. Responses in the skin microenvironment impact the potential for sensitization and these responses may include the presence of proinflammatory cytokines, inflammasome activation, barrier integrity, skin microbiota, and the presence of immune cells. Selection of mouse strain to evaluate skin effects, such as haired (BALB/c) or hairless (SKH1) mice, varies dependent on the experimental design and needs of a study. However, dermal chemical exposure may impact reactions in the skin differently depending on the strain of mouse. Additionally, there is a need for established methods to evaluate immune responses in the skin. In this study, exposure to the immunomodulatory chemical triclosan was evaluated in two mouse models using immunophenotyping by flow cytometry and gene expression analysis.  The flow cytometry panel reported in this manuscript in combination with gene expression analysis may be used in future studies to better evaluate the effect of chemical exposures on the skin immune response.  These findings may be important to consider during strain selection, experimental design, and result interpretation of chemical exposures on the skin.
Patent AT-E40102-T1: [Translated] PROCESS FOR THE CONTINUOUS HOMOLOGIZATION OF METHANOL.

1. Process for the hydroformylation of methanol, characterized in that the reaction is carried out in the presence of a catalyst comprising : a) cobalt and/or (a) cobalt compound(s), b) at least one iodide of the group : LiJ, NaJ, KJ, RbJ, CsJ, (N R1 R2 R3 R4 ) **+J**- , and/or compounds, which form at least one iodide of this group, whereby R1 , R2 , R3 and R4 may be H, alkyl- and aryl group, preferably H, CH3 , C2 H5 and C6 H5 , c) methyl iodide and/or methyl iodide forming compounds in the presence of 1,4-dioxane and/or alkylated 1,4-dioxane and that the hydroformylation is carried out continuously and the catalyst is recycled.