AndreaBozzo/ceres-open-data-index huggingface dataset:
Extracting biological information from DNA arrays: an unexpected link between arginine and methionine metabolism in

Background
          In global gene expression profiling experiments, variation in the expression of genes of interest can often be hidden by general noise. To determine how biologically significant variation can be distinguished under such conditions we have analyzed the differences in gene expression when Bacillus subtilis is grown either on methionine or on methylthioribose as sulfur source.
        
        
          Results
          An unexpected link between arginine metabolism and sulfur metabolism was discovered, enabling us to identify a high-affinity arginine transport system encoded by the yqiXYZ genes. In addition, we tentatively identified a methionine/methionine sulfoxide transport system which is encoded by the operon ytmIJKLMhisP and is presumably used in the degradation of methionine sulfoxide to methane sulfonate for sulfur recycling. Experimental parameters resulting in systematic biases in gene expression were also uncovered. In particular, we found that the late competence operons comE, comF and comG were associated with subtle variations in growth conditions.
        
        
          Conclusions
          Using variance analysis it is possible to distinguish between systematic biases and relevant gene-expression variation in transcriptome experiments. Co-variation of metabolic gene expression pathways was thus uncovered linking nitrogen and sulfur metabolism in B. subtilis.
Daily Census Tract-Level PM2.5 Concentrations, 2006-2010

This dataset provides modeled predictions of PM2.5 levels from the EPA's Downscaler model. Data are at the census tract level for 2006-2010. These data are used by the CDC's National Environmental Public Health Tracking Network to generate air quality measures. Census tract-level datasets contain estimates of the mean predicted concentration and associated standard error. Please refer to the metadata attachment for more information.

Learn more about outdoor air quality on the Tracking Network's website: https://ephtracking.cdc.gov/showAirLanding.action.

By using these data, you signify your agreement to comply with the following requirements:
1. Use the data for statistical reporting and analysis only.
2. Do not attempt to learn the identity of any person included in the data and do not combine these data with other data for the purpose of matching records to identify individuals.
3. Do not disclose of or make use of the identity of any person or establishment discovered inadvertently and report the discovery to: trackingsupport@cdc.gov.
4. Do not imply or state, either in written or oral form, that interpretations based on the data are those of the original data sources and CDC unless the data user and data source are formally collaborating.
5. Acknowledge, in all reports or presentations based on these data, the original source of the data and CDC.
6. Suggested citation: Centers for Disease Control and Prevention. National Environmental Public Health Tracking Network. Web. Accessed: insert date. www.cdc.gov/ephtracking.
Montana (MT)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Montana for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.
Oral contraceptive use before first birth and risk of breast cancer: a case control study

Background
          The aim of this study was first, to investigate whether women starting oral contraceptive (OC) use at a young age and before first birth have an increased risk for breast cancer and second, to report difficulties encountered in studying long-term health impacts of medical technologies.
        
        
          Methods
          Breast cancers occurring up until 1997 among 37153 Helsinki students born between 1946 and 1960 were identified by record linkage from the Finnish Cancer Registry; for each cancer case, five age-matched random controls were picked from the same student population. Those who had used the Helsinki Student Health Service (HSHS) at least three times (150 cases and 316 controls) form the final study subjects. Data on OC use and background characteristics were collected from patient records, and data on live births were derived from the population register. Odds ratios (OR) were adjusted for number of births, smoking and sports activity.
        
        
          Results
          Compared to the few non-users, OC users had a higher risk of breast cancer: the adjusted OR was 2.1 (95% confidence interval 1.1–4.2). Among OC users, no statistically significant differences in risk of breast cancer were found in regard to starting age or first birth, but small numbers made confidence intervals wide. Even though we had chosen students to be our study group, the population turned out to be unsuitable to answer our research question: most women had started their OC use old (at the age of 20 or later) and there were very few unexposed (almost all had used OC and before their first birth).
        
        
          Conclusions
          Because adoption of the modern pattern of OC use was not common among students, it is unlikely that the impact of early and extended OC use can be studied before 2010, when women born in the 1960s are 40 to 50 years old.
Patent AT-E400337-T1: [Translated] SYSTEM FOR ASSOCIATING A UNIQUE IDENTIFIER WITH A GAME TICKET

In a method of a method of linking a unique identifier to an instant game ticket, a user is instructed to enter a unique identifier on an identifier entry mechanism. An image of the unique identifier is received from the user via the identifier entry mechanism. The unique identifier is stored in a computer-readable memory. A representation of the unique identifier and at least one game result is printed on an instant win game ticket. The user is instructed not to accept the instant win game ticket unless the representation of the unique identifier printed thereon corresponds to the unique identifier that the user entered on the identifier entry mechanism.
In 2012, 57 Percent of Substance Abuse Treatment Facilities Provided Community Outreach - Up from 47 Percent in 2006

This is a National Survey of Substance Abuse Treatment Services (N-SSATS)  spotlight showing the percent of substance abuse treatment facilities provided community outreach in 2012 compared to 2006. The National Survey of Substance Abuse Treatment Services (N-SSATS) is an annual survey designed to collect information from all facilities in the United States, both public and private, that provide substance abuse treatment.
Compound 527604: 4-Penten-2-ol, bromoacetate

Chemical compound data from PubChem database. IUPAC Name: pent-4-en-2-yl 2-bromoacetate. Molecular Formula: C7H11BrO2. Molecular Weight: 207.06. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E40119-T1: [Translated] SUBSTITUTED 5-AMINO-1-PHENYLPYRAZOLES.

Herbicidally active 5-amino-1-phenylpyrazoles of the formula <IMAGE>   in which R is CN, or an ester or amido group, R1 is an organic radical, R2 is an organic radical, hydrogen or an acyl or thioacyl radical, R3, R4, R5, R6 and R7 can be hydrogen or various organic radicals but at least one is a haloalkyl, haloalkoxy, haloalkylthio, haloalkylsulphinyl or haloalkylsulphonyl radical, but R is not CN at the same time as R5 is CF3. The compounds   <IMAGE> are intermediates therefor and are also herbicidal.
Phorbol esters and CAMP differentially regulate the expression of CD4 and CD8 in human thymocytes

Background
          Intrathymic development and selection of the T lymphocyte repertoire is restricted by the interactions of the T cell antigen receptor and CD4 or CD8 co-receptors with self major histocompatibility complex molecules. Positive or negative selection depends on a tight regulatory control of CD4 and CD8 expression. Determining the intracellular signals that differentially regulate the expression of CD4 and CD8 is important to understand the mechanisms that are implicated in selection of single positive CD4+CD8- or CD4-CD8+.
        
        
          Results
          The present study shows that stimulation of human thymocytes by phorbol esters or cAMP result in a differential regulation of CD4 and CD8 expression, both at the mRNA and cell surface glycoprotein level.
        
        
          Conclusions
          The differential regulation of CD4 and CD8 gene expression suggests that the selective activation of protein kinase C (PKC) and cAMP-dependent protein kinases (PKA) may be required for the selection of single positive CD4+CD8- and CD4-CD8+ cells during Intrathymic differentiation
NNDSS - TABLE 1J. Dengue virus infections, Dengue to Severe dengue

NNDSS - TABLE 1J. Dengue virus infections, Dengue to Severe dengue - 2021. In this Table, provisional cases* of notifiable diseases are displayed for United States, U.S. territories, and Non-U.S. residents.

Notice: Due to data processing issues at CDC, data for the following jurisdictions may be incomplete for week 7: Alaska, Arizona, California, Connecticut, Delaware, Florida, Hawaii, Louisiana, Maryland, Michigan, Missouri, North Dakota, New Hampshire, New York City, Oregon, Pennsylvania, and Rhode Island.

Note: 
This table contains provisional cases of national notifiable diseases from the National Notifiable Diseases Surveillance System (NNDSS). NNDSS data from the 50 states, New York City, the District of Columbia and the U.S. territories are collated and published weekly on the NNDSS Data and Statistics web page (https://wwwn.cdc.gov/nndss/data-and-statistics.html). Cases reported by state health departments to CDC for weekly publication are provisional because of the time needed to complete case follow-up. Therefore, numbers presented in later weeks may reflect changes made to these counts as additional information becomes available. The national surveillance case definitions used to define a case are available on the NNDSS web site at https://wwwn.cdc.gov/nndss/. Information about the weekly provisional data and guides to interpreting data are available at: https://wwwn.cdc.gov/nndss/infectious-tables.html. 

Footnotes:
U: Unavailable — The reporting jurisdiction was unable to send the data to CDC or CDC was unable to process the data.
-: No reported cases — The reporting jurisdiction did not submit any cases to CDC.
N: Not reportable — The disease or condition was not reportable by law, statute, or regulation in the reporting jurisdiction.
NN: Not nationally notifiable — This condition was not designated as being nationally notifiable.
NP: Nationally notifiable but not published.
NC: Not calculated — There is insufficient data available to support the calculation of this statistic.
Cum: Cumulative year-to-date counts.
 Max: Maximum — Maximum case count during the previous 52 weeks.
  * Case counts for reporting years 2020 and 2021 are provisional and subject to change. Cases are assigned to the reporting jurisdiction submitting the case to NNDSS, if the case's country of usual residence is the U.S., a U.S. territory, unknown, or null (i.e. country not reported); otherwise, the case is assigned to the 'Non-U.S. Residents' category. Country of usual residence is currently not reported by all jurisdictions or for all conditions. For further information on interpretation of these data, see https://wwwn.cdc.gov/nndss/document/Users_guide_WONDER_tables_cleared_final.pdf.
†Previous 52 week maximum and cumulative YTD are determined from periods of time when the condition was reportable in the jurisdiction (i.e., may be less than 52 weeks of data or incomplete YTD data).
CDC WONDER: Mortality - Multiple Cause of Death

<p>The Mortality - Multiple Cause of Death data on CDC WONDER are county-level national mortality and population data spanning the years 1999-2009. Data are based on death certificates for U.S. residents. Each death certificate contains a single underlying cause of death, up to twenty additional multiple causes (Boolean set analysis), and demographic data. The number of deaths, crude death rates, age-adjusted death rates, standard errors and 95% confidence intervals for death rates can be obtained by place of residence (total U.S., region, state, and county), age group (including infants and single-year-of-age cohorts), race (4 groups), Hispanic ethnicity, sex, year of death, and cause-of-death (4-digit ICD-10 code or group of codes, injury intent and mechanism categories, or drug and alcohol related causes), year, month and week day of death, place of death and whether an autopsy was performed. The data are produced by the National Center for Health Statistics.</p>
Nutrient Content of the U.S. Food Supply, 1909-2010

The data presented in this dataset is invaluable for monitoring the potential of the food supply to meet nutritional needs; for examining relationships between food supply nutrients and health; and for examining dietary trends of Americans. Additionally, food supply nutrient estimates reflect Federal enrichment and fortification standards and technological advances in the food industry and contribute to the Federal dietary guidance system. As such, these data are of interest to agricultural policymakers, economists, nutrition researchers, and nutrition and public health educators. Data are provided for the following nutrients and their food sources from the major food groups.
Compound 527979: 1-Propanol, 3-chloro, butanoate

Chemical compound data from PubChem database. IUPAC Name: 3-chloropropyl butanoate. Molecular Formula: C7H13ClO2. Molecular Weight: 164.63. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 530432: Sclareoloxide(Cis-B/C)

Chemical compound data from PubChem database. IUPAC Name: 3,4a,7,7,10a-pentamethyl-1,5,6,6a,8,9,10,10b-octahydrobenzo[f]chromene. Molecular Formula: C18H30O. Molecular Weight: 262.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Multipletelophase arrest bypassed (tab)mutants alleviate the essential requirement for Cdc15 in exit from mitosis inS. cerevisiae

The Mitotic Exit Network (MEN) proteins – including the protein kinase Cdc15 and the protein phosphatase Cdc14 – are essential for exit from mitosis inSaccharomyces cerevisiae.To identify downstream targets of the MEN, we soughttelophase arrest bypassed (tab)mutations that bypassed the essential requirement forCDC15.Previous studies identifiednet1tab2-1andCDC14TAB6-1as mutations in the RENT complex subunits Net1 and Cdc14, respectively, and revealed that the MEN acts by promoting release of Cdc14 from its nucleolar Net1 anchor during anaphase. However, the remainingtabmutants were not characterized.
Compound 529383: 3(2H)-Furanone, 5-methyl-2-octyl-

Chemical compound data from PubChem database. IUPAC Name: 5-methyl-2-octylfuran-3-one. Molecular Formula: C13H22O2. Molecular Weight: 210.31. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528375: 1,2,4-Trihydroxymenthane

Chemical compound data from PubChem database. IUPAC Name: 1-methyl-4-propan-2-ylcyclohexane-1,2,4-triol. Molecular Formula: C10H20O3. Molecular Weight: 188.26. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
2016 National Directory of Mental Health Treatment Facilities

This publication is a National Directory of Mental Health Treatment Facilities for 2016. This directory is a listing of Federal, State, and local government facilities and private facilities that provide mental health treatment services. It includes treatment facilities that responded to the 2015 National Mental Health Services Survey (N-MHSS). The information about each facility that appears in this Directory was provided by that facility in response to the 2015 N-MHSS. The N-MHSS is conducted annually by the Substance Abuse and Mental Health Services Administration (SAMHSA). The Directory is ordered alphabetically by State, by city within each State, and by facility name within each city. This Directory include mental health treatment facilities for all U.S. states and territories.
HAICViz - CDI

<p>The healthcare-associated infection component of CDC’s <a href="https://www.cdc.gov/ncezid/dpei/eip/index.html" target="_blank">EIP</a> engages a <a href="https://www.cdc.gov/ncezid/dpei/eip/eip-sites.html" target="_blank">network</a> of state health departments and their academic medical center partners to help answer critical questions about emerging HAI threats, advanced infection tracking methods, and antibiotic resistance in the United States. Information gathered through this activity will play a key role in shaping future policies and recommendations targeting HAI prevention. </p>
Arthritis Research: the move to publish research articles in full online only

WhenArthritis Researchwas launched in 1999 the publishers and ourselves took the innovative decision to make all primary research articles available to everyone for free through the journal's own websitehttp://arthritis-research.comas well as through PubMed Centralhttp://www.pubmedcentral.nih.gov/, the National Institute of Health's repository for biomedical research articles, and through the BioMed Central (BMC) websitehttp://biomedcentral.com. We now feel that it is time to lead the way forward again by only publishing research articles in full online beginning with volume 4 number 4 ofArthritis Research.
The role of IFN-gamma in systemic lupus erythematosus: a challenge to the Th1/Th2 paradigm in autoimmunity

Cytokines play a critical role in regulating lymphoid cell responses to most antigenic stimuli, and it is therefore very likely that these molecules profoundly affect the pathogenesis of autoimmune diseases. Consequently, investigations of the role of cytokines as effectors or predisposing elements in these diseases have received prominent attention for many years. Early findings from such studies, however, were frequently contradictory and, more importantly, difficult to incorporate into a conceptual framework. A new impetus in this area was provided by the discovery of Mosmann and colleagues that T cells could be conveniently divided into two main subsets, ie Th1 and Th2, with distinct arrays of cytokine secretion patterns and functions [1,2]. A hypothesis was subsequently formulated according to which cell-mediated autoimmune diseases, such as insulin-dependent diabetes mellitus, are induced by Th1 cells and their cytokines, and humorally-mediated autoimmune diseases, such as systemic lupus erythematosus, are induced by Th2 cells and their cytokines. As reviewed below, findings on the primary role of IFN-γ in the pathogenesis of murine lupus and other observations clearly refute this hypothesis.
Assessing the contribution of the herpes simplex virus DNA polymerase to spontaneous mutations

Background
          The thymidine kinase (tk) mutagenesis assay is often utilized to determine the frequency of herpes simplex virus (HSV) replication-mediated mutations. Using this assay, clinical and laboratory HSV-2 isolates were shown to have a 10- to 80-fold higher frequency of spontaneous mutations compared to HSV-1.
        
        
          Methods
          A panel of HSV-1 and HSV-2, along with polymerase-recombinant viruses expressing type 2 polymerase (Pol) within a type 1 genome, were evaluated using the tk and non-HSV DNA mutagenesis assays to measure HSV replication-dependent errors and determine whether the higher mutation frequency of HSV-2 is a distinct property of type 2 polymerases.
        
        
          Results
          Although HSV-2 have mutation frequencies higher than HSV-1 in the tk assay, these errors are assay-specific. In fact, wild type HSV-1 and the antimutator HSV-1 PAAr5 exhibited a 2–4 fold higher frequency than HSV-2 in the non-HSV DNA mutatagenesis assay. Furthermore, regardless of assay, HSV-1 recombinants expressing HSV-2 Pol had error rates similar to HSV-1, whereas the high mutator virus, HSV-2 6757, consistently showed signficant errors. Additionally, plasmid DNA containing the HSV-2 tk gene, but not type 1 tk or LacZ DNA, was shown to form an anisomorphic DNA stucture.
        
        
          Conclusions
          This study suggests that the Pol is not solely responsible for the virus-type specific differences in mutation frequency. Accordingly, it is possible that (a) mutations may be modulated by other viral polypeptides cooperating with Pol, and (b) the localized secondary structure of the viral genome may partially account for the apparently enhanced error frequency of HSV-2.
Tribal Consultation Meetings Regarding Requirements Applicable to  Title IV-B Child and Family Services Plan (Volume 77, Number 34)

Tribal Consultation Meetings Regarding Requirements Applicable to Title IV-B Child and Family Services Plan
  
  

 - This notice from the Federal Register requests comments from Indian tribes that operate a title IV-B, subpart 1 and/or title IV-B, subpart 2 program or any other interested party about possible revisions to the title IV-B regulations regarding the title IV-B plan and fiscal requirements.

Metadata-only record linking to the original dataset. Open original dataset below.
Age-dependent changes in 24-hour rhythms of catecholamine content and turnover in hypothalamus, corpus striatum and pituitary gland of rats injected with Freund's adjuvant

Background
          Little information is available on the circadian sequela of an immune challenge in the brain of aged rats. To assess them, we studied 24-hour rhythms in hypothalamic and striatal norepinephrine (NE) content, hypothalamic and striatal dopamine (DA) turnover and hypophysial NE and DA content, in young (2 months) and aged (18–20 months) rats killed at 6 different time intervals, on day 18th after Freund's adjuvant or adjuvant's vehicle administration.
        
        
          Results
          Aging decreased anterior and medial hypothalamic NE content, medial and posterior hypothalamic DA turnover, and striatal NE concentration and DA turnover. Aging also decreased NE and DA content in pituitary neurointermediate lobe and augmented DA content in the anterior pituitary lobe. Immunization by Freund's adjuvant injection caused: (i) reduction of DA turnover in anterior hypothalamus and corpus striatum; (ii) acrophase delay of medial hypothalamic DA turnover in old rats, and of striatal NE content in young rats; (iii) abolition of 24-h rhythm in NE and DA content of neurointermediate pituitary lobe, and in DA content of anterior lobe, of old rats.
        
        
          Conclusions
          The decline in catecholamine neurotransmission with aging could contribute to the decrease of gonadotropin and increase of prolactin release reported in similar groups of rats. Some circadian responses to immunization, e.g. suppression of 24-h rhythms of neurointermediate lobe NE and DA and of anterior lobe DA were seen only in aged rats.