AndreaBozzo/ceres-open-data-index huggingface dataset:
Early Identification of Developmental Disabilities in Foster/Adoptive Homes

This webinar, featuring Dr. Jacqueline Bertrand and Dr. Rebecca Wolf of the Centers for Disease Control and Prevention (CDC), describes programs and materials available from the CDC that can assist foster and adoptive parents with the identification of and referrals for children with developmental disabilities. It focuses on children with fetal alcohol spectrum disorders or autism spectrum disorders and highlights the CDC’s Learn the Signs Act Early program.

View Webinar (WMV – 87,032 KB)
View Transcript (PDF) (PDF - 227 KB)
View Presentation Slides (PDF) (PDF - 2,258 KB)

Metadata-only record linking to the original dataset. Open original dataset below.
Compound 528827: 1,2-Diethoxy-4-ethylbenzene

Chemical compound data from PubChem database. IUPAC Name: 1,2-diethoxy-4-ethylbenzene. Molecular Formula: C12H18O2. Molecular Weight: 194.27. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Detection and characterization of the

Background
          Virulence genes on Salmonella pathogenicity island 1 (SPI1) are coordinately regulated by HilA, a member of the OmpR/ToxR family of transcription factors. Although a great deal is known about the complex regulation of hilA gene expression, very little is known about the HilA protein.
        
        
          Results
          In order to detect and localize the HilA protein in S. typhimurium, we raised polyclonal antiserum against purified His-tagged HilA. This allowed us to study the effect of environmental conditions on the production of HilA. We also used the antiserum to examine the fractionation properties and SDS-PAGE mobility of native HilA. Our results indicate that S. typhimurium initiates translation of HilA from the first AUG codon in the hilA open-reading frame (ORF), producing a soluble 553 amino acid (63 kDa) protein product.
        
        
          Conclusion
          Materials and methods are now available to study the environmental regulation of the HilA protein in S. typhimurium. Our results also indicate that future in vitro studies of the interaction between HilA and DNA should utilize soluble preparations of HilA. Previous analyses used preparations of HilA in which the protein fractionated with the membrane, greatly limiting the types of experiments that could be conducted.
Physiologic role of interleukin-1 receptor antagonist

Recent studies have described the spontaneous development of			 arthritis or vasculitis in IL-1 receptor antagonist (IL-1Ra) knockout mice bred			 on specific and different genetic backgrounds. The levels of both secreted and			 intracellular isoforms of IL-1Ra produced in the rheumatoid joint or in the			 arterial wall may not be adequate to effectively inhibit the excess amounts of			 locally produced IL-1. Thus, an imbalance between IL-1 and IL-1Ra may			 predispose to local inflammatory disease in particular tissues in the presence			 of other as yet unknown genetically influenced factors.
Compound 525904: N,N-Dimethyl-N'-hexyl-isobutyramidine

Chemical compound data from PubChem database. IUPAC Name: N'-hexyl-N,N,2-trimethylpropanimidamide. Molecular Formula: C12H26N2. Molecular Weight: 198.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
National Pregnancy and Health Survey: Drug Use Among Women Delivering Live Births (NPHS-1992)

<p>The primary objective of the National Pregnancy and Health<br />
Survey (NPHS) was to produce national annual estimates of the<br />
percentages and numbers of mothers of live newborns in the United<br />
States who used selected licit and illicit drugs in the 12 months<br />
prior to delivery. A further objective was to describe patterns of<br />
prenatal substance use among demographic subgroups of<br />
women. Information on demographic and socioeconomic characteristics,<br />
obstetric history, and drug treatment of women who delivered infants<br />
at sampled hospitals was obtained through an interviewer-administered<br />
questionnaire, while data on substance use before and during pregnancy<br />
were collected through a questionnaire completed by the respondent and<br />
concealed from the interviewer. Respondents were asked about use of<br />
the following substances: alcohol, amphetamines, analgesics, cocaine,<br />
crack cocaine, barbiturates, hallucinogens, hashish, heroin,<br />
marijuana, methadone, methamphetamine, sedatives, stimulants, tobacco,<br />
and tranquilizers. Additionally, information was collected on the<br />
respondent's pregnancy, prenatal care, delivery, previous pregnancies,<br />
and background. Additional data were obtained from the mothers' and<br />
infants' medical records. Urine specimens collected routinely by the<br />
hospital on obstetric admissions were tested for selected<br />
drugs. Finally, in a subsample of six hospitals, hair specimens were<br />
requested from respondents to evaluate the potential of hair as a<br />
source of toxicological data in future studies.This study has 1 Data Set.</p>
NNDSS - TABLE 1HH. Streptococcal toxic shock syndrome to Syphilis, Primary and Secondary

NNDSS - TABLE 1HH. Streptococcal toxic shock syndrome to Syphilis, Primary and Secondary - 2019. In this Table, provisional cases* of notifiable diseases are displayed for United States, U.S. territories, and Non-U.S. residents. 

Note: 
This table contains provisional cases of national notifiable diseases from the National Notifiable Diseases Surveillance System (NNDSS). NNDSS data from the 50 states, New York City, the District of Columbia and the U.S. territories are collated and published weekly on the NNDSS Data and Statistics web page (https://wwwn.cdc.gov/nndss/data-and-statistics.html). Cases reported by state health departments to CDC for weekly publication are provisional because of the time needed to complete case follow-up. Therefore, numbers presented in later weeks may reflect changes made to these counts as additional information becomes available. The national surveillance case definitions used to define a case are available on the NNDSS web site at https://wwwn.cdc.gov/nndss/. Information about the weekly provisional data and guides to interpreting data are available at: https://wwwn.cdc.gov/nndss/infectious-tables.html. 

Footnotes:
U: Unavailable — The reporting jurisdiction was unable to send the data to CDC or CDC was unable to process the data.
-: No reported cases — The reporting jurisdiction did not submit any cases to CDC.
N: Not reportable — The disease or condition was not reportable by law, statute, or regulation in the reporting jurisdiction.
NN: Not nationally notifiable — This condition was not designated as being nationally notifiable.
NP: Nationally notifiable but not published — CDC does not have data because of changes in how conditions are categorized.
Cum: Cumulative year-to-date counts.
Max: Maximum — Maximum case count during the previous 52 weeks.
* Case counts for reporting years 2018 and 2019 are provisional and subject to change. Cases are assigned to the reporting jurisdiction submitting the case to NNDSS, if the case's country of usual residence is the US, a US territory, unknown, or null (i.e. country not reported); otherwise, the case is assigned to the 'Non-US Residents' category. For further information on interpretation of these data, see https://wwwn.cdc.gov/nndss/document/Users_guide_WONDER_tables_cleared_final.pdf. 
† Previous 52 week maximum and cumulative YTD are determined from periods of time when the condition was reportable in the jurisdiction (i.e., may be less than 52 weeks of data or incomplete YTD data).
Genomic organization of

Background
          The tropomodulins (TMODs) are a family of proteins that cap the pointed ends of actin filaments. Four TMODs have been identified in humans, with orthologs in mice. Mutations in actin or actin-binding proteins have been found to cause several human diseases, ranging from hypertrophic cardiomyopathy to immunodefiencies such as Wiskott-Aldrich syndrome. We had previously mapped Tropomodulin 2 (TMOD2) to the genomic region containing the gene for amyotrophic lateral sclerosis 5 (ALS5). We determined the genomic structure of Tmod2 in order to better analyze patient DNA for mutations; we also determined the genomic structure of Tropomodulin 4 (TMOD4).
        
        
          Results
          In this study, we determined the genomic structure of TMOD2 and TMOD4 and found the organization of both genes to be similar. Sequence analysis of TMOD2 revealed no mutations or polymorphisms in ALS5 patients or controls. Interestingly, we discovered that another gene, YL-1, intergenically splices into TMOD4. YL-1 encodes six exons, the last of which is 291 bp from a 5' untranslated exon of TMOD4. We used 5' RACE and RT-PCR from TMOD4 to identify several intergenic RACE products. YL-1 was also found to undergo unconventional splicing using non-canonical splice sites within exons (intraexonic splicing) to produce several alternative transcripts.
        
        
          Conclusions
          The genomic structure of TMOD2 and TMOD4 have been delineated. This should facilitate future mutational analysis of these genes. In addition, intergenic splicing at TMOD4/YL-1 was discovered, demonstrating yet another level of complexity of gene organization and regulation.
Compound 528614: N-Isobutylcyclopropanecarboxamide

Chemical compound data from PubChem database. IUPAC Name: N-(2-methylpropyl)cyclopropanecarboxamide. Molecular Formula: C8H15NO. Molecular Weight: 141.21. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 529483: 3(2H)-Furanone, 2-acetyl-4-hydroxy

Chemical compound data from PubChem database. IUPAC Name: 2-acetyl-4-hydroxyfuran-3-one. Molecular Formula: C6H6O4. Molecular Weight: 142.11. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 526704: perfluoro-pentan ethioic acid S-methyl ester

Chemical compound data from PubChem database. IUPAC Name: S-methyl 2,2,3,3,4,4,5,5,5-nonafluoropentanethioate. Molecular Formula: C6H3F9OS. Molecular Weight: 294.14. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Provider Network Data: 2022 Quarter 1

This Provider Network Data contains information on individual and institutional providers participating in health plan networks from January through March 2022. Plan network data is collected from Medicaid, Commercial, and Exchange plans on a quarterly basis by the Department of Health, including managed care plans, as well as PPO/EPO plans.

For more information, please visit: <a href=https://pndslookup.health.ny.gov>https://pndslookup.health.ny.gov</a>
Denver: Drug-Related Emergency Department Visits, 2004-2011 - Nonmedical Use of Pharmaceuticals

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving the nonmedical use of pharmaceuticals (prescription and over-the-counter medications and dietary supplements) for the Denver metropolitan area, covering 2004-2011.  Nonmedical use includes patients who took a higher than prescribed or recommended dose of their own medication, patients who took a pharmaceutical prescribed for another person, malicious poisoning of the patient by another individual, and documented substance abuse involving pharmaceuticals
Breaching the kinetic barrier to

Abstract
          Here we have reviewed the conventional definitions and fundamental
characteristics of the two basic types of stem cells, embryonic stem cells (ESCs) and somatic stem cells (SSCs). By taking into account the often-overlooked asymmetric cell kinetics of SSCs, we consider the evidence that should SSCs retain these growth kinetics in vitro, a natural kinetic barrier to SSC propagation exists. Recent discoveries showing that the tumor suppressor gene
p53 can act as a regulator of asymmetric cell kinetics provide a
target pathway for in vitro SSC propagation strategies.
Patent AT-E399852-T1: [Translated] LOW ALCOHOL BEERS OR BEER-LIKE SOFT DRINKS WITH PALATINOSE

Producing a beer containing little or no alcohol, or a beverage with a beer character, comprising producing a wort by mixing brewing water with hops and a carbohydrate, where the wort is boiled and then fermented, a mixture with a palatinose content or palatinose alone is added before or during or after fermentation, as a syrup, solution, or solid crystals, is new. Producing a beer containing little or no alcohol, or a beverage with a beer character, comprises producing a wort by mixing brewing water with hops and a carbohydrate, where the wort is boiled and then fermented, a mixture with a palatinose content or palatinose alone is added before or during or after fermentation, as a syrup, solution, or solid crystals. At least one microorganism is selected for the fermentation from an under- or over-fermented saccharomyces cerevisiae source, saccharomyces carisbergensis, saccharomyces diastaticus and brettanomyces intermedius. The carbohydrate is malted corn or raw fruit with malted corn.
Ablation of atrial fibrillation: a procedure come of age?

Various approaches for catheter ablation of focal initiators of atrial fibrillation or the substrate for maintaining atrial fibrillation have evolved over the past 5 years. Despite these advances, there are still a large number of unresolved issues regarding the efficacy and safety of these procedures as well as optimal patient selection for the different approaches. These uncertainties raise questions about the applicability at the present time of atrial fibrillation as front-line therapy within the community.
Compound 526158: Dibutyl 4-bromo-phenyl phosphate

Chemical compound data from PubChem database. IUPAC Name: (4-bromophenyl) dibutyl phosphate. Molecular Formula: C14H22BrO4P. Molecular Weight: 365.2. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Nevada 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.
Compound 529745: 1-Methyltetradecyl 3-fluorobenzoate

Chemical compound data from PubChem database. IUPAC Name: 2-[(2-methylfuran-3-yl)disulfanyl]pentan-3-one. Molecular Formula: C10H14O2S2. Molecular Weight: 230.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528139: 5-Isopropyl-3-methyl-2-methoxypyrazine

Chemical compound data from PubChem database. IUPAC Name: 2-methoxy-3-methyl-5-propan-2-ylpyrazine. Molecular Formula: C9H14N2O. Molecular Weight: 166.22. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Program Instruction (PI-08-04)

This Program Instruction (PI) provides instruction to Tribes on the June 30, 2008 submission of the Annual Progress and Services Report (APSR) required under Title IV-B of the Social Security Act (the Act), including the submission of the CFS-101, Part I - Annual Budget Request, Part II - Annual Summary of Child and Family Services, and Part III, Annual Expenditures for Title IV-B, Subparts 1 and 2.

Metadata-only record linking to the original dataset. Open original dataset below.
Compound 526403: 2-Bromo,1,8,9-trichloro-dibenzo-dioxin

Chemical compound data from PubChem database. IUPAC Name: 2-bromo-1,8,9-trichlorodibenzo-p-dioxin. Molecular Formula: C12H4BrCl3O2. Molecular Weight: 366.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E400695-T1: [Translated] DOUBLE-LAYER TECHNICAL FABRIC

In a lower surface side layer of an industrial two-layer fabric, warps are formed by sequentially arranging a repeating design unit, in which one warp passes over six successive lower surface side wefts, passes under one lower surface side weft, passes over two lower surface side wefts, and passes under one lower surface side weft while shifting the design by three lower surface side wefts. Two adjacent lower surface side warps simultaneously weave therein, from the lower surface side, one lower surface side weft, whereby the lower surface side weft passes over two lower surface side warps and then passes under eight lower surface side warps to form a weft long crimp corresponding to eight lower surface side warps on the lower surface side surface.
Patent AT-E399940-T1: [Translated] STROKE CONTROL IN RECUBING MACHINE

The method of determining the path of a variable run piston compressor for a motor vehicle air conditioner (1) using swash plate pistons determines the path indirectly. The data is taken from a differential pressure PD (11) or a speed V (14) of volumetric discharge and a pressure difference between high pressure DP and aspiration pressure with respect to the compressor speed. The differential pressure can be determined from the compressor volumetric flow and the flow pressure drop across a resistance.
NLM Classification

A product of the National Library of Medicine for the arrangement of library materials in the field of medicine and related sciences used internationally.  The NLM Classification is updated twice a year with the winter edition published in January and the summer edition published in August. Publication of printed editions ceased with the 5th revised edition, 1999. Beginning with the 2006 edition, the NLM Classification is also available in PDF (Portable Document Format) at https://www.nlm.nih.gov/class/terms_cond.html
Crystal structure of murine sCEACAM1a[1,4]: a coronavirus receptor in the CEA family

CEACAM1 is a member of the carcinoembryonic antigen (CEA) family. Isoforms of murine CEACAM1 serve as receptors for mouse hepatitis virus (MHV), a murine coronavirus. Here we report the crystal structure of soluble murine sCEACAM1a[1,4], which is composed of two Ig-like domains and has MHV neutralizing activity. Its N-terminal domain has a uniquely folded CC′ loop that encompasses key virus-binding residues. This is the first atomic structure of any member of the CEA family, and provides a prototypic architecture for functional exploration of CEA family members. We discuss the structural basis of virus receptor activities of murine CEACAM1 proteins, binding of Neisseria to human CEACAM1, and other homophilic and heterophilic interactions of CEA family members.
Compound 526402: 2-Bromo,1,6,9-trichloro-dibenzo-dioxin

Chemical compound data from PubChem database. IUPAC Name: 2-bromo-1,6,9-trichlorodibenzo-p-dioxin. Molecular Formula: C12H4BrCl3O2. Molecular Weight: 366.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Risk and Protective Factor Tables (Prevalence Estimates) - 3.1 to 3.25

These detailed tables present totals and prevalence estimates of risk and protective factors regarding substance use from the 2012 National Survey on Drug Use and Health (NSDUH). The factors include perceptions of 1) risk of substance use, 2) availability of substances, 3) parental disapproval of youth substance use, 4) peer substance use. They also include measures of delinquent behavior, religious involvement, exposure to prevention messages, and parental involvement.  Results are provided by age group, gender, race/ethnicity, geographic area, and youth substance use behavior. Comparisons are made between 2012 and 2011.
Patent AT-E40096-T1: [Translated] METHOD OF TREATMENT OF FERROUS SULPHATEPHEPTOHYDRATE TO SUPRESS ITS TENDENCE TO AGGLOMERATE, ALLOWING IT TO FLOW FREELY.

1. A process for treating ferrous sulphate crystallized in the heptahydrate form having trace amounts of intercrystalline water containing free acid in which, in order to suppress the tendency of the crystals to agglomerate and to render them able to flow freely, the traces of water are eliminated by adding, in intimate mixture, to this ferrous sulphate a ferrous sulphate which is underhydrated to 40.5% by weight at most, in an amount at least sufficient to compensate for the trace amounts of intercrystalline water, characterized in that the underhydration of the added ferrous sulphate is at least 10% by weight, and the free acid is neutralized by the addition of 0.5 to 2% by weight of a pulverulent neutralizing agent.
The Yersinia YopE and YopH type III effector proteins enhance bacterial proliferation following contact with eukaryotic cells

Background
          Several bacterial pathogens express antihost factors that likely decrease both their maximal growth rate (due to metabolic costs) as well as their mortality rate (by neutralizing host defenses). The pathogenic yersiniae make a huge metabolic investment expressing virulence proteins (referred to as Yops) that are directly injected into eukaryotic cells and that modulate host defense responses such as phagocytosis and stress-activated signaling pathways. Although host-cell contact enhanced Yop expression as well as the cellular activities of several Yops have recently been described, a clear link between these phenomena and bacterial survival and/or proliferation remains to be established
        
        
          Results
          We show that the proliferation of Y. pseudotuberculosis is compromised when the bacterium is growing in association with eukaryotic cells compared to free-living bacteria. One factor likely limiting Yersinia proliferation is the metabolically taxing expression of yopE which we show using flow cytometry increases in individual bacteria following their contact with cultured macrophage-like cells. An additional factor limiting Y. pseudotuberculosis proliferation are host cell defense systems which can be significantly ameliorated by disrupting the host cell cytoskeletal system by either exogenously added toxins or by the bacterial-mediated injection of YopE or YopH.
        
        
          Conclusions
          Our results demonstrate that despite their metabolic costs the Yop virulence proteins play an important role in enabling Y. pseudotuberculosis to survive and proliferate when confronted with the antimicrobial activities of the eukaryotic cell.