AndreaBozzo/ceres-open-data-index huggingface dataset:
MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, Alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders

Background
          Patients with Opitz GBBB syndrome present with a variable array of developmental defects including craniofacial, cardiac, and genital anomalies. Mutations in the X-linked MID1 gene, which encodes a microtubule-binding protein, have been found in ~50% of Opitz GBBB syndrome patients consistent with the genetically heterogeneous nature of the disorder. A protein highly related to MID1, called MID2, has also been described that similarly associates with microtubules.
        
        
          Results
          To identify protein partners of MID1 and MID2 we undertook two separate yeast two-hybrid screens. Using this system we identified Alpha 4, a regulatory subunit of PP2-type phosphatases and a key component of the rapamycin-sensitive signaling pathway, as a strong interactor of both proteins. Analysis of domain-specific deletions has shown that the B-boxes of both MID1 and MID2 mediate the interaction with Alpha 4, the first demonstration in an RBCC protein of a specific role for the B-box region. In addition, we show that the MID1/2 coiled-coil motifs mediate both homo- and hetero-dimerisation, and that dimerisation is a prerequisite for association of the MID-Alpha 4 complex with microtubules.
        
        
          Conclusions
          Our findings not only implicate Alpha 4 in the pathogenesis of Opitz GBBB syndrome but also support our earlier hypothesis that MID2 is a modifier of the X-linked phenotype. Of further note is the observation that Alpha 4 maps to Xq13 within the region showing linkage to FG (Opitz-Kaveggia) syndrome. Overlap in the clinical features of FG and Opitz GBBB syndromes warrants investigation of Alpha 4 as a candidate for causing FG syndrome.
Patent AT-E400987-T1: [Translated] COMPOSITE CERAMIC SUBSTRATE

In a conventional composite ceramic substrate, the entire ceramic substrate is bent corresponding to bending of a motherboard. Therefore, when the ceramic substrate is mounted with surface-mounted components such as passive components and active components, these surface-mounted components cannot correspond to the bending of the ceramic substrate. This may cause breaking of wire arisen from disconnection of terminals for external connection of the surface-mounted components from electrodes of the ceramic substrate.  The composite ceramic substrate 10 of the present invention includes a ceramic substrate 12 mounted with surface-mounted components 11, external terminal electrodes 14 connecting wiring patterns 13 disposed on the ceramic substrate 12 and surface electrodes of a motherboard 20, and a convex leg portion 15 formed of resin such that an end face supports the external terminal electrodes 14, and the external terminal electrodes 14 are connected to the wiring patterns 13 via a via-hole conductor 15B formed in the leg portion 14.
2008-2010 NSDUH Substate Region Estimates Categorized into Seven Groups by Age Group

This table uses 2008 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past year alcohol use disorder and illicit drug use disorder among persons aged 12 or older by 362 substate regions within the 50 States and the District of Columbia. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). This table presents age group differences.
Patent AT-E399689-T1: [Translated] WHEEL HUB

The wheel hub (10) is assembled of a brake unit comprising a set of stationary (14) and a set of movable disks (16), an outer hub (18) and a brake housing (20), forming a space (22) for the multi-disk unit (12). A coolant is moved inside the inner space (22, 36). The outer hub (18) is provided with a collar (24) at its outer contour with several openings (26) for the insertion of bolts (28). The bolts (28) are no longer accommodated partly inside the housing (20), resulting in an increase of the space available for the coolant.
Program Information Report

The Office of Head Start (OHS) Program Information Report (PIR) provides comprehensive data on the services, staff, children, and families served by Head Start and Early Head Start programs nationwide. All grant recipients and delegates are required to submit a PIR for Head Start and Early Head Start programs.

<b>Units of Response: </b>Head Start and Early Head Start Programs and Participants

<b>Type of Data: </b>Administrative

<b>Tribal Data: </b>Yes

<b>COVID-19 Data: </b>Unavailable

<b>Periodicity: </b>Annual

<b>SORN: </b>Not Applicable

<b>Data Use Agreement: </b>Yes

<b>Data Use Agreement Location: </b>https://hses.ohs.acf.hhs.gov/auth/login

<b>Equity Indicators: </b>Disability;Ethnicity;Housing Status;Indigenous Population;Race

<b>Granularity: </b>Program

<b>Spatial: </b>United States

<b>Geocoding: </b>Unavailable
Evolution of gene order conservation in prokaryotes

Background
          As more complete genomes are sequenced, conservation of gene order between different organisms is emerging as an informative property of the genomes. Conservation of gene order has been used for predicting function and functional interactions of proteins, as well as for studying the evolutionary relationships between genomes. The reasons for the maintenance of gene order are still not well understood, as the organization of the prokaryote genome into operons and lateral gene transfer cannot possibly account for all the instances of conservation found. Comprehensive studies of gene order are one way of elucidating the nature of these maintaining forces.
        
        
          Results
          Gene order is extensively conserved between closely related species, but rapidly becomes less conserved among more distantly related organisms, probably in a cooperative fashion. This trend could be universal in prokaryotic genomes, as archaeal genomes are likely to behave similarly to bacterial genomes. Gene order conservation could therefore be used as a valid phylogenetic measure to study relationships between species. Even between very distant species, remnants of gene order conservation exist in the form of highly conserved clusters of genes. This suggests the existence of selective processes that maintain the organization of these regions. Because the clusters often span more than one operon, common regulation probably cannot be invoked as the cause of the maintenance of gene order.
        
        
          Conclusions
          Gene order conservation is a genomic measure that can be useful for studying relationships between prokaryotes and the evolutionary forces shaping their genomes. Gene organization is extensively conserved in some genomic regions, and further studies are needed to elucidate the reason for this conservation.
Clinical significance of cardiovascular dysmetabolic syndrome

Although diabetes mellitus is predominantly a metabolic disorder, recent data suggest that it is as much a vascular disorder. Cardiovascular complications are the leading cause of death and disability in patients with diabetes mellitus. A number of recent reports have emphasized that many patients already have atherosclerosis in progression by the time they are diagnosed with clinical evidence of diabetes mellitus. The increased risk of atherosclerosis and cardiovascular complications in diabetic patients is related to the frequently associated dyslipidemia, hypertension, hyperglycemia, hyperinsulinemia, and endothelial dysfunction. The evolving knowledge regarding the variety of metabolic, hormonal, and hemodynamic abnormalities in patients with diabetes mellitus has led to efforts designed for early identification of individuals at risk of subsequent disease. It has been suggested that insulin resistance, the key abnormality in type II diabetes, often precedes clinical features of diabetes by 5–6 years. Careful attention to the criteria described for the cardiovascular dysmetabolic syndrome should help identify those at risk at an early stage. The application of nonpharmacologic as well as newer emerging pharmacologic therapies can have beneficial effects in individuals with cardiovascular dysmetabolic syndrome and/or diabetes mellitus by improving insulin sensitivity and related abnormalities. Early identification and implementation of appropriate therapeutic strategies would be necessary to contain the emerging new epidemic of cardiovascular disease related to diabetes.
Weekly Counts of Deaths by Jurisdiction, and Race and Hispanic Origin

Effective September 27, 2023, this dataset will no longer be updated. Similar data are accessible from wonder.cdc.gov.

This visualization provides weekly data on the number of deaths from all causes by jurisdiction of occurrence and race and Hispanic origin. Numbers of deaths are also shown for all causes excluding COVID-19, and for COVID-19. Counts of deaths in more recent weeks can be compared with counts from earlier years to determine if the number is higher than expected.
Compound 528230: 1-(2-Hydroxyethylthio)-2-(vinylthio)ethane

Chemical compound data from PubChem database. IUPAC Name: 2-(2-ethenylsulfanylethylsulfanyl)ethanol. Molecular Formula: C6H12OS2. Molecular Weight: 164.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E401719-T1: [Translated] TRAFFIC NETWORK FLOW CONTROL USING DYNAMIC MODIFIED MERITS FOR REDUNDANCY CONNECTIONS

Distance vector routing protocols such as the Routing Information Protocol fail to rapidly reconfigure to use redundant links. By modifying the outgoing advertised hop count upon detecting a failure in a connection for which a backup or redundant connection exists, incoming traffic is diverted to the redundant or backup connection. An artificially high hop count is advertised for a given port, and when a failure or loss of reachability occurs in a connection associated with that port, an advertisement of a lower hop count on the backup or redundant connection for the given port is triggered. This causes rapid rerouting of incoming traffic to the backup or redundant connection.
Compound 529187: Tetradecyl tert-butyldimethylsilyl ether

Chemical compound data from PubChem database. IUPAC Name: tert-butyl-dimethyl-tetradecoxysilane. Molecular Formula: C20H44OSi. Molecular Weight: 328.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E401299-T1: [Translated] PROCESS FOR THE PRODUCTION OF HYDROXYETHYLAMINES

Chemical patent from PubChem database. Patent Number: AT-E401299-T1. Title: Process for Preparing Therapeutic Agents. Filing Date: 1995-05-02. Inventors: Chen, Wei, Kumar, Raj, Williams, Sarah. Abstract: A process for preparing therapeutic agents is described, involving multiple synthetic steps with optimized reaction conditions. The process enables la... IPC Classifications: C07H, A61K, A61P. This patent covers 33 claims related to 6 chemical compounds. Useful for intellectual property research, prior art searches, and chemical innovation tracking.
Compound 528419: Dihydrochalcone, 2',4',6'-trihydroxy-4-methoxy, tris-TMS

Chemical compound data from PubChem database. IUPAC Name: 1-(4-methoxyphenyl)-3-[2,4,6-tris(trimethylsilyloxy)phenyl]propan-1-one. Molecular Formula: C25H40O5Si3. Molecular Weight: 504.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 530066: 17-[1,2-bis(trimethylsilyloxy)ethyl]-N-methoxy-10,13-dimethyl-17-trimethylsilyloxy-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-imine

Chemical compound data from PubChem database. IUPAC Name: 17-[1,2-bis(trimethylsilyloxy)ethyl]-N-methoxy-10,13-dimethyl-17-trimethylsilyloxy-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-imine. Molecular Formula: C31H59NO4Si3. Molecular Weight: 594.1. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528100: tert-Butyl(dimethyl)silyl pentanoate

Chemical compound data from PubChem database. IUPAC Name: [tert-butyl(dimethyl)silyl] pentanoate. Molecular Formula: C11H24O2Si. Molecular Weight: 216.39. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Guide to the NYTD Review Transmittal Letter

The Children's Bureau  re-issued the Guide to the NYTD Review (the Guide), previously issued in January 2017 in ACYF-CB-PI-17-01. The revisions to this document, while minor, offer clarifications that we hope will assist states in better preparing for the onsite review and understanding the requirements subject to review.

Metadata-only record linking to the original dataset. Open original dataset below.
Compound 528173: 1,3-Cyclopentadiene, 2-(2-methylpropyl)

Chemical compound data from PubChem database. IUPAC Name: 2-(2-methylpropyl)cyclopenta-1,3-diene. Molecular Formula: C9H14. Molecular Weight: 122.21. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
2018 N-SSATS State Profiles

These state profiles includes data from facilities that reported to N-SSATS for the survey reference date March 30, 2018. The N-SSATS collects data on the location, characteristics, services offered, and number of clients (collected every other year) in treatment at alcohol and drug abuse treatment facilities (public and private) throughout the 50 states, the District of Columbia, U.S. territories, and other jurisdictions.
Respiratory effects of dexmedetomidine in the surgical patient requiring intensive care

The respiratory effects of dexmedetomidine were retrospectively examined in 33 postsurgical patients involved in a randomised, placebo-controlled trial after extubation in the intensive care unit (ICU). Morphine requirements were reduced by over 50% in patients receiving dexmedetomidine. There were no differences in respiratory rates, oxygen saturations, arterial pH and arterial partial carbon dioxide tension (PaCO2) between the groups. Interestingly the arterial partial oxygen tension (PaO2) : fractional inspired oxygen (FIO2) ratios were statistically significantly higher in the dexmedetomidine group. Dexmedetomidine provides important postsurgical analgesia and appears to have no clinically important adverse effects on respiration in the surgical patient who requires intensive care.
Patent AT-E401804-T1: [Translated] REMOTE MEASUREMENT SYSTEM FOR COMMUNICATION WITH AN ACTIVE DEVICE IMPLANTED IN THE CHEST OF A PATIENT

The equipment has a wave collector (16) sensitive to a magnetic field to exchange signals via an inductive channel with an active implantable medical device (14). A connection unit (22) connects the collector to a signal processing and transmitting and receiving electronic unit (24). An adjusting unit fixes a wave collector support (18) in a location of a garment (10) such that, after initial positioning of the collector to a right of a thorax region, the collector is positioned and maintained in the former position at each threading of the garment by the patient.
Facility-Level Minimum Data Set Frequency

The Facility-Level Minimum Data Set (MDS) Frequency dataset provides information for active nursing home residents on topics, such as race/ethnicity, age, or marital status; discharge dispositions; hearing, speech, and vision; cognitive patterns; mood; functional abilities and goals; bladder and bowel; active diagnoses; health conditions; swallowing/nutritional status; oral/dental status; skin conditions; medications; special treatments, procedures, and programs; restraints and alarms; and participation in assessment and goal setting.
Patent AT-E400119-T1: [Translated] CELLULAR COMMUNICATION SYSTEM IN WHICH MOBILE STATIONS SERVE AS RELAY STATIONS

Chemical patent from PubChem database. Patent Number: AT-E400119-T1. Title: Pharmaceutical Salt Forms. Filing Date: 1997-07-03. Inventors: Kim, Young-Soo, Taylor, Elizabeth. Abstract: Novel pharmaceutical salt forms are provided, exhibiting improved physicochemical properties including enhanced solubility, stability, and bioavailabi... IPC Classifications: A61K, A61L, A61F. This patent covers 44 claims related to 7 chemical compounds. Useful for intellectual property research, prior art searches, and chemical innovation tracking.
NNDSS - TABLE 1X. Meningococcal disease, Other serogroups to Meningococcal disease, Unknown serogroup

NNDSS - TABLE 1X. Meningococcal disease, Other serogroups to Meningococcal disease, Unknown serogroup - 2022. In this Table, provisional cases* of notifiable diseases are displayed for United States, U.S. territories, and Non-U.S. residents.

Notes:

•	These are weekly cases of selected infectious national notifiable diseases, from the National Notifiable Diseases Surveillance System (NNDSS). NNDSS data reported by the 50 states, New York City, the District of Columbia, and the U.S. territories are collated and published weekly as numbered tables available at https://www.cdc.gov/nndss/data-statistics/index.html. Cases reported by state health departments to CDC for weekly publication are subject to ongoing revision of information and delayed reporting. Therefore, numbers listed in later weeks may reflect changes made to these counts as additional information becomes available. Case counts in the tables are presented as published each week. See also Guide to Interpreting Provisional and Finalized NNDSS Data at https://www.cdc.gov/nndss/docs/Readers-Guide-WONDER-Tables-20210421-508.pdf.
• Notices, errata, and other notes are available in the Notice To Data Users page at https://wonder.cdc.gov/nndss/NTR.html.
•	The list of national notifiable infectious diseases and conditions and their national surveillance case definitions are available at https://ndc.services.cdc.gov/. This list incorporates the Council of State and Territorial Epidemiologists (CSTE) position statements approved by CSTE for national surveillance.

Footnotes:

*Case counts for reporting years 2021 and 2022 are provisional and subject to change. Cases are assigned to the reporting jurisdiction submitting the case to NNDSS, if the case's country of usual residence is the U.S., a U.S. territory, unknown, or null (i.e. country not reported); otherwise, the case is assigned to the 'Non-U.S. Residents' category. Country of usual residence is currently not reported by all jurisdictions or for all conditions. For further information on interpretation of these data, see https://www.cdc.gov/nndss/docs/Readers-Guide-WONDER-Tables-20210421-508.pdf.
†Previous 52 week maximum and cumulative YTD are determined from periods of time when the condition was reportable in the jurisdiction (i.e., may be less than 52 weeks of data or incomplete YTD data).
U: Unavailable — The reporting jurisdiction was unable to send the data to CDC or CDC was unable to process the data.
-: No reported cases — The reporting jurisdiction did not submit any cases to CDC.
N: Not reportable — The disease or condition was not reportable by law, statute, or regulation in the reporting jurisdiction.
NN: Not nationally notifiable — This condition was not designated as being nationally notifiable.
NP: Nationally notifiable but not published.
NC: Not calculated — There is insufficient data available to support the calculation of this statistic.
Cum: Cumulative year-to-date counts.
Max: Maximum — Maximum case count during the previous 52 weeks.
Combating Kinetoplastid diseases

Today's Kinetoplastida form a diverse order of flagellated protozoans that have evolved from an ancient lineage, rooted near the base of the eukaryotic tree. The disease caused by some species of the Order Kinetoplastida have always plagued mankind, and today most are at least as prevalent as they have ever been. Kinetoplastid parasites cause disease in humans, animals and plants, severely affecting human health and retarding agriculture development in less developed countries. Sleeping sickness (caused by pathogenic subspecies ofTrypanosoma brucei), Chagas disease (caused byTrypanosoma cruzi) and the Leishmaniases (caused byLeishmania spp) are the major human diseases caused by kinetoplastids. According to the World Health Organization "sleeping sickness" affects more than 60 million men, women and children in 36 countries of sub-Saharan Africa, most of which are among the least developed countries in the world. In many of these countries sleeping sickness is currently epidemic, re-emerging in some as a greater cause of morbidity than evenHIV/AIDS.T. cruzicurrently infects 14 million people in Latin America. It is the agent ofChagas disease, the leading infectious cardiomyopathy in the world. Theleishmaniasesand the suffering they cause threaten 350 million women, men and children in 88 countries around the world, 72 of which are developing countries. In addition to their medical importance kinetoplastid parasites also cost developing nations millions of dollars in lost agricultural revenues, since other kinetoplastids are pestilences that strike agricultural produce from crops, to fish to cattle.
Patent AT-E401808-T1: [Translated] DEVICE FOR ADJUSTING THE LENGTH OF A BRACELET, BRACELET COMPRISING SUCH A DEVICE, AND WATCH EQUIPPED WITH SUCH A BRACELET

The device (28) has a base plate (24) and adjusting links (30) provided at respective longitudinal ends, where one of the links is articulated on the base plate through a rod (32). The rod is articulated on the base plate through a main axle (A1) and on the link through a secondary axle (A2), in which the links are arranged in a manner to slide relative to the plate. A locking device (58) permits the link to grip an anchoring element (60) that is arranged on the plate along two indexed longitudinal positions defining two lengths of strap, respectively.
Immune modulation in the treatment of respiratory infection

The limitations of currently available treatment for severe respiratory infection are demonstrated by the relatively fixed mortality associated with these infections despite advances in nutrition, vaccines, antibiotics, and critical care. This might be due in part to the changing spectrum of pathogens and development of drug resistance. Cytokines are potent molecules that function as growth factors and orchestrate both innate and adaptive immune responses. Several of these factors have entered the clinical arena to support or augment the immune response. Moreover, the use of cytokines has recently been expanded to patients without an overtly defective immune system but who have either significant infection or infection with drug resistant organisms. The use of cytokines as adjuvants in the treatment of respiratory infections is reviewed.
Compound 528086: Ethyl N-(O-anisyl)carbamate

Chemical compound data from PubChem database. IUPAC Name: ethyl N-(2-methoxyphenyl)carbamate. Molecular Formula: C10H13NO3. Molecular Weight: 195.21. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.