AndreaBozzo/ceres-open-data-index huggingface dataset:
Boston

Data tables consisting of Excel files with estimates, rates, relative standard errors, trends and confidence intervals, covering 2004-2011, for drug-related emergency department visits for the Boston Metropolitan Statistical Area. Tables are provided for 10 topics (\"analytic categories\") which are defined in the \"Guide to Drug Abuse Warning Trend Tables,\"  a separate document.   Each table includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol. Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology. Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.
MD COVID-19 - Total Number Released from Isolation: CovidLINK

<b>NOTE:</b> This layer is deprecated (last updated 3/14/2022). Was formerly a daily update.

<b>Summary</b>
The cumulative number of COVID-19 positive Maryland residents who have been released from home isolation.

<b>Description</b>
The MD COVID-19 - Total Number Released from Isolation data layer is a collection of the statewide cumulative total of individuals who tested positive for COVID-19 that have been reported each day by each local health department via the ESSENCE system as having been released from home isolation. As "recovery” can mean different things as people experience COVID-19 disease to varying degrees of severity, MDH reports on individuals released from isolation. “Released from isolation” refers to those who have met criteria and are well enough to be released from home isolation. Some of these individuals may have been hospitalized at some point.

<b>Terms of Use</b>
The Spatial Data, and the information therein, (collectively the "Data") is provided "as is" without warranty of any kind, either expressed, implied, or statutory. The user assumes the entire risk as to quality and performance of the Data. No guarantee of accuracy is granted, nor is any responsibility for reliance thereon assumed. In no event shall the State of Maryland be liable for direct, indirect, incidental, consequential or special damages of any kind. The State of Maryland does not accept liability for any damages or misrepresentation caused by inaccuracies in the Data or as a result to changes to the Data, nor is there responsibility assumed to maintain the Data in any manner or form. The Data can be freely distributed as long as the metadata entry is not modified or deleted. Any data derived from the Data must acknowledge the State of Maryland in the metadata.
L-Glutamate production by lysozyme-sensitive

Background
          A non-pathogenic species of coryneform bacteria, Corynebacterium glutamicum, was originally isolated as an L-glutamate producing bacterium and is now used for fermentative production of various amino acids. A mutation in the C. glutamicum ltsA gene caused susceptibility to lysozyme, temperature-sensitive growth, and L-glutamate production.
        
        
          Results
          The characteristics of eight lysozyme-sensitive mutants which had been isolated after N-methyl-N'-nitro-N-nitrosoguanidine mutagenesis were examined. Complementation analysis with the cloned wild-type ltsA gene and DNA sequencing of the ItsA region revealed that four mutants had a mutation in the ltsA gene. Among them, two mutants showed temperature-sensitive growth and overproduced L-glutamate at higher temperatures, as well as the previously reported ltsA mutant. Other two showed temperature-resistant growth: one missense mutant produced L-glutamate to some extent but the other nonsense mutant did not. These two mutants remained temperature-resistant in spite of introduction of ltsA::kan mutation that causes temperature-sensitive growth in the wild-type background.
        
        
          Conclusions
          These results indicate that a defect caused by the ltsA mutations is responsible for temperature-sensitive growth and L-glutamate overproduction by C. glutamicum. The two temperature-resistant mutants seem to carry suppressor mutations that rendered cells temperature-resistance and abolished L-glutamate overproduction.
A geometric and algebraic view of MHC-peptide complexes and their binding properties

Background
          Major histocompatibility complex (MHC) molecules present peptides to T lymphocytes. It is of critical biological and medical importance to elucidate how different MHC alleles bind to a specific set of peptides.
        
        
          Method
          In this study we approach the problem from the algebraic and geometric point of view to analyse MHC-peptide-binding data accumulated over the years. The space of sequence properties (having a particular amino acid at a particular position) of MHC-peptide complexes conveys a geometric structure to these sequence properties in the form of a distance measure, which reveals the peptide binding requirements imposed by the polymorphic sequence characteristics of the MHC molecules.
        
        
          Results
          Comparison of the results of this study with our current knowledge of MHC-peptide binding constraints leads to robust agreement. This study provides the tools to quantitate these binding constraints giving a more detailed account of them and opening the way to make peptide binding predictions for MHC alleles for which there is no peptide elution data. In addition, the geometric representation of MHC-peptide complex sequence data gives a distance measure between amino acids in reference to their ability to meet MHC binding requirements.
        
        
          Conclusions
          The algebraic and geometric view of amino acid sequences provides a theoretical framework to study the function of proteins when there is enough variation in this sequence to account for the variation in their function, as it is the case with MHC molecules in regard to their ability to present peptides.
Nerve agent exposure and physiological stress alter brain microstructure and immune profiles after inflammatory challenge in a long-term animal model of Gulf War Illness

Gulf War Illness (GWI) is a disorder experienced by one-third of the veterans of the 1990-91 Gulf War, with symptoms including fatigue, chronic pain, respiratory and memory problems. Exposure to toxic chemicals during the war, such as oil well fire smoke, pesticides, physiological stress, and nerve agents, is thought to have triggered abnormal neuroinflammatory responses that contribute to GWI. Previous studies using animal models have indicated that combined exposure to high physiological stress and GW-relevant organophosphates, such as sarin nerve agent and chlorpyrifos and dichlorvos, produces neuroinflammation and changes in diffusion magnetic resonance imaging (MRI) measures, suggesting a neuroimmune basis for GWI. In the current study, we examined brain structure and immune function of a chronic rat model of GWI and showed that a combination of long-term corticosterone treatment (CORT, to mimic high physiological stress) and diisopropyl fluorophosphate exposure (DFP, to mimic sarin exposure) resulted in elevations of multiple inflammatory cytokines, an increased activated microglial population, and disrupted brain microstructure in the hippocampal regions. Moreover, prior exposures to these agents modeling the “in-theater,” initiating exposure conditions experienced by veterans with GWI can induce long-term alterations in neuroimmune signaling, resulting in an exacerbated neuroinflammatory response to future immune challenges.  The goal of the study was to establish a long-term model of GWI in rats that would be more relevant to the current state of ill veterans.  As such, rats were initially exposed to the stress hormone corticosterone (CORT) for 1 week followed by a single exposure to the sarin surrogate diisopropyl fluorophosphate, to mimic “in-theater” conditions of high physiological stress and nerve agent exposure.  This initial exposure was followed up with 4 weeks of intermittent re-exposure to week-long bouts of CORT and a final exposure to the prototypical inflammagen, lipopolysaccharide (LPS) to mimic a systemic inflammatory challenge.
Substance Use and Mental Health Estimates from the 2013 National Survey on Drug Use and Health: Overview of Findings

This report uses 2013 National Survey on Drug Use and Health (NSDUH) to assess the prevalence of substance use and mental disorders among those aged 12 or older, adolescents aged 12 to 17, and adults aged 18 or older and the receipt of treatment/services for behavioral health issues. The 2013 rates of suicide ideation and rates of co-occurring substance use and mental health disorders are also presented.
Trafficking Victim Assistance Program Data

TVAP grant project participants through the grantees on a monthly, quarterly, or annual basis, including participant demographics (age, sex, and country of origin), type of trafficking experienced (sex, labor, or both), enrollment status, types of services and benefits provided, types of health screening and medical services received, the names of the entities providing medical services, the amount of money expended on each type of medical service provided, types of partnerships developed through the grant with subrecipients, and the types of training and technical assistance provided to subrecipient organizations or other partners.

<b>Units of Response: </b>Foreign National Victims of Human Trafficking

<b>Type of Data: </b>Administrative

<b>Tribal Data: </b>Unavailable

<b>COVID-19 Data: </b>Unavailable

<b>Periodicity: </b>Annual

<b>SORN: </b>Not Applicable

<b>Data Use Agreement: </b>Unavailable

<b>Data Use Agreement Location: </b>Unavailable

<b>Equity Indicators: </b>Disability;Ethnicity;Gender Identity;Housing Status;Indigenous Population;Race

<b>Granularity: </b>Unavailable

<b>Spatial: </b>United States

<b>Geocoding: </b>Country of Origin
Compound 528362: 1,3,5-Oxathiazine, perhydro, 2,4,6-trimethyl

Chemical compound data from PubChem database. IUPAC Name: 2,4,6-trimethyl-1,3,5-oxathiazinane. Molecular Formula: C6H13NOS. Molecular Weight: 147.24. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 526450: Pentafluoropropionic acid, pentyl ester

Chemical compound data from PubChem database. IUPAC Name: pentyl 2,2,3,3,3-pentafluoropropanoate. Molecular Formula: C8H11F5O2. Molecular Weight: 234.16. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 530233: 5-Methyl-4-trimethylsilyloxy-1-[4-trimethylsilyloxy-5-(trimethylsilyloxymethyl)oxolan-2-yl]pyrimidin-2-one

Chemical compound data from PubChem database. IUPAC Name: 5-methyl-4-trimethylsilyloxy-1-[4-trimethylsilyloxy-5-(trimethylsilyloxymethyl)oxolan-2-yl]pyrimidin-2-one. Molecular Formula: C19H38N2O5Si3. Molecular Weight: 458.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 525064: Methyl 10-hydroxydecanoate, TMS

Chemical compound data from PubChem database. IUPAC Name: methyl 10-trimethylsilyloxydecanoate. Molecular Formula: C14H30O3Si. Molecular Weight: 274.47. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E401427-T1: [Translated] METHOD FOR SEPARATING ZINC AND NICKEL IN THE PRESENCE OF CHLORIDE IONS

A method for the separation of zinc and a second metal which does not form an anionic complex in the presence of chloride ions, zinc and the second metal being present in an effluent in the form of ZnCl2 and a second metal chloride. The formation of the anionic complex is obtained by bringing the effluent into contact with the resin saturated with chloride ions. The second metal chloride is extracted by means of a first eluent, followed by extraction of zinc with a degree of oxidation of +II. Generally, the second metal is a transition metal such as Cr, Cu, Ni, Fe and, more specifically, nickel.
Dental Utilization Measures and Sealant Data by County, Ethnicity, & Age Calendar Year 2013 to 2022

This dataset shows use of Medi-Cal dental benefits by Medi-Cal members displayed by county, ethnicity, age groups and calendar year (2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, and 2022). This information consists of members receiving dental services in the following categories: Annual Dental Visit, Exams/Oral Health Evaluations, Use of Diagnostic Services, Use of Dental Treatment Services, Use of Preventive Services, Use of Restorative Services, Treatment/Prevention for Caries, and Use of Sealants. The Medi-Cal members were continuously enrolled in either Dental Managed Care or the Dental Fee-for-Service delivery system for at least 3 months during each measure year.
2014 National Survey on Drug Use and Health: Mental Health Estimates Computed Directly from the Clinical Sample of the Mental Health Surveillance Study and Measures of their Standard Errors

This document focuses on how the prevalence estimates and their standard errors were derived from the 2008 to 2012 MHSS clinical sample. In particular, it describes how the prevalence estimates covering the 2008 to 2012 time period were computed using sampling weights that had undergone a number of calibration adjustments with an emphasis on the last adjustment: poststratification—the annual calibration of the clinical sample to the NSDUH control totals. It then discusses several alternative methods for measuring the standard errors of those estimates.
Compound 530372: 1,3-Benzenediol, 4,6-dichloro, bis-TMS

Chemical compound data from PubChem database. IUPAC Name: (2,4-dichloro-5-trimethylsilyloxyphenoxy)-trimethylsilane. Molecular Formula: C12H20Cl2O2Si2. Molecular Weight: 323.36. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Indicators for 2012B

Physician Fee Schedule - March 2012 release. This file contains the revisions identified in the Middle Class Tax Relief and Job Creation Act of 2012 (MCTRJCA). Medicare payment rates under the Medicare Physician Fee Schedule (MPFS) are set according to statutory criteria. The following 2012 MPFS payment rates are reflective of the CY 2012 Medicare Physician Fee Schedule Final Rule, which was published in the Federal Register on November 28, 2011, and the CY 2012 Medicare Physician Fee Schedule Final Rule Correction Notice, which was published in the Federal Register on January 4, 2012. These payment rates are based on current law, including the Middle Class Tax Relief and Job Creation Act of 2012 (MCTRJCA), which provides for a zero percent update through December 31, 2012. The MCTRJCA extends several provisions of the Temporary Payroll Tax Cut Continuation Act of 2011 (TPTCCA). Please note that MCTRJCA does NOT extend add-on payments for mental health services and minimum payment for bone mass measurement (sections 307 and 309 of the TPTCCA, respectively). As such, effective March 1, 2012, the MPFS payment rates for these services have changed. 2012A: Medicare payment rates under the Medicare Physician Fee Schedule (MPFS) are set according to statutory criteria. The following 2012 MPFS payment rates are reflective of the CY 2012 Medicare Physician Fee Schedule Final Rule, which was published in the Federal Register on November 28, 2011, and the CY 2012 Medicare Physician Fee Schedule Final Rule Correction Notice that was put on display at the Office of the Federal Register on December 30, 2011. These payment rates are based on current law, including the Temporary Payroll Tax Cut Continuation Act of 2011, which provides for a zero percent update for the period of January 1, 2012 to February 29, 2012. The Centers for Medicare and Medicaid Services will work quickly to update MPFS payment rates in the event Congress passes legislation to prevent the negative update from going into effect on March 1, 2012. Please be on the alert for more information about the 2012 physician update as it becomes available.
Patent AT-E399803-T1: [Translated] POLYMER WHICH RELEASES EVEN AN AMINO ACID DERIVATIVE, COSMETIC AND FIBER CONSTRUCT WITH THE POLYMER, PRODUCTION PROCESS THEREOF AND REGENERATION PROCESS THEREOF

The object of the present invention is to provide a polymer which achieves an ef fect of supplementing the water-retaining function of horny layer and keeping the normal skin by a gradual supplying of an amino acid derivative to the skin through moisture containing electrolyte salt such as sweat perspired from human body and to provide a cosmetic and a fiber structure containing said polymer.  According to the present invention, there is provided sustained-release polymer for amino acid derivative,  characterized in that , a polymer containing acidic group is ionically bonded to an amino acid derivative. Cosmetic and fiber structure containing the same are also provided.
Compound 526801: 2-Hydroxy-stearic acid, methyl ester, 2-tBDMS ether

Chemical compound data from PubChem database. IUPAC Name: methyl 2-[tert-butyl(dimethyl)silyl]oxyoctadecanoate. Molecular Formula: C25H52O3Si. Molecular Weight: 428.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Percentage of Drivers and Front Seat Passengers Wearing Seat Belts, 2012 & 2014, Region 1 - Boston

Source for 2012 national data: National Occupant Protection Use Survey (NOPUS), 2012. Source for 2014 national data: National Occupant Protection Use Survey (NOPUS), 2014.  Source for 2012 state data: State Observational Survey of Seat Belt Use, 2012. Source for 2014 state data: Seat Belt Use in 2014- Use Rates in the States and Territories
Survey of the knowledge, attitude and practice of Nigerian surgery trainees to HIV-infected persons and AIDS patients

Background
          The incidence of HIV infection and AIDS is rising in Nigeria. Surgeons are at risk of occupationally acquired infection as a result of intimate contact with the blood and body fluids of patients. This study set out to determine the knowledge, attitude and risk perception of Nigerian surgery residents to HIV infection and AIDS.
        
        
          Methods
          A self-administered postal questionnaire was sent to all surgery trainees in Nigeria in 1997.
        
        
          Results
          Parenteral exposure to patients' blood was reported as occurring 92.5% times, and most respondents assessed their risk of becoming infected with HIV as being moderate at 1–5%. The majority of the respondents were not aware of the CDC guidelines on universal precautions against blood-borne pathogens. Most support a policy of routinely testing all surgical patients for HIV infection but 76.8% work in centers where there is no policy on parenteral exposure to patients' blood and body fluids. Most (85.6%) do not routinely use all the protective measures advocated for the reduction of transmission of blood borne pathogens during surgery, with the majority ascribing this to non-availability. Most want surgeons to be the primary formulators of policy on HIV and surgery while not completely excluding other stakeholders.
        
        
          Conclusions
          The study demonstrates the level of knowledge, attitude and practice of Nigerian surgery trainees in 1997 and the need for policy guidelines to manage all aspects of the healthcare worker (HCW), patients, and HIV/AIDS interaction.
Effect of alpha-tocopherol on pulmonary antioxidant defence system and lipid peroxidation in cigarette smoke inhaling mice

Background
          Free radicals generated in biological systems by cigarette smoke (CS) inhalation can cause oxidative stress in tissues, resulting in lipid peroxidation (LPO). In view of the antioxidant properties of α-tocopherol (AT), in the present study, effects of AT on antioxidant defence system and LPO were investigated in mice inhaling CS for different time intervals.
        
        
          Results
          Male Balb/c mice were fed orally with AT (5 I.U./Kg.b.wt.) and /or exposed to CS for 2, 4, 6 or 8 weeks. No effect was observed on body growth, diet consumption, water intake and lung weight due to AT and /or CS treatment in any of the groups as compared to their control counterparts. After two weeks of treatment, no change in LPO, reduced glutathione (GSH) levels and antioxidant enzymes were observed except for glutathione reductase (GR) which increased in all the treated groups. A significant increase in pulmonary LPO levels was observed in mice exposed to CS inhalation for 4, 6 or 8 weeks. There was a gradual increase in the LPO levels as the extent of CS inhalation increased from 4 to 8 weeks. However, the extent of increase in LPO levels due to CS exposure for 4, 6 or 8 weeks in the mice treated with AT was comparatively less. A significant decrease in the GSH levels was also observed in all the animals exposed to CS for 4, 6 or 8 weeks. There was a significant increase in the activities of catalase, glutathione peroxidase (GSH-Px) and GR observed in all the groups exposed to CS for 4,6 or 8 weeks. The increase in above antioxidant enzymes seems to be insufficient to combat the oxidative stress posed by CS inhalation. There was a marked decrease observed in the LPO levels in the animals treated with AT alone for 4, 6, or 8 weeks, when compared to their control counterparts. However, the supplementation of AT for 4, 6 or 8 weeks demonstrated a significant increase in GSH levels.
        
        
          Conclusion
          It appears from our studies that AT exhibits its antioxidant role either directly by scavenging the oxidative species or indirectly by modulating the GSH levels.
The ETS domain-containing hematopoietic transcription factor PU.1 mediates the induction of arachidonate 5-lipoxygenase by multi-walled carbon nanotubes in macrophages in vitro

Fibrogenic multi-walled carbon nanotubes (MWCNTs) polarize macrophages to M1 cells with elevated production of proinflammatory lipid mediators (LMs) to boost acute inflammation. Here we examined the mechanism by which MWCNTs (Mitsui-7) induce arachidonate 5-lypoxygenase (Alox5) critical for production of chemotactic LM leukotriene B4 (LTB4) in murine and human macrophages.
Patent AT-E401538-T1: [Translated] LOW TEMPERATURE COOLING METHOD AND SYSTEM WITH A SHORT TERM OPEN CIRCUIT COOLING ARRANGEMENT FOR SUPERCONDUCTIVE FIELD WINDING

A cooling fluid system (50) is disclosed for providing cryogenic cooling fluid to a high temperature super-conducting machine (10), wherein said system includes a main cooling system (52) and a second cooling system (54) said second cooling system comprising a storage device (74) having a first cryogenic fluid (70); at least one cooling coupling (82) in fluid communication with the first cryogenic fluid from the storage device and a second cryogenic fluid flowing through the main cooling system.
Compound 529273: 1-Hexyne, 4,5-dimethyl

Chemical compound data from PubChem database. IUPAC Name: 4,5-dimethylhex-1-yne. Molecular Formula: C8H14. Molecular Weight: 110.2. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.