AndreaBozzo/ceres-open-data-index huggingface dataset:
ROCKWOOL-Duke Comparative Indigenous Child Welfare Contact Database

The ROCKWOOL-Duke Comparative Indigenous Child Welfare Contact dataset compiles cross-national aggregate information about child welfare contact of indigenous (or native, aboriginal) children compared to non-indigenous children, between 2010 and 2023, from 3 countries who have a history of colonial rule: Denmark, Greenland (Kalaallit Nunaat), and the United States. This dataset is a new and unique resource for comparative and longitudinal research of how indigenous children’s child welfare outcomes differ to those of non-indigenous children. 
Data were collected from national child welfare or national statistical agencies, and measures include notifications of child maltreatment, investigations of maltreatment, confirmed cases of maltreatment, placements in out-of-home care, and the number of children in out-of-home care. Population data are also included for the measurement of incidence and prevalence of system contact. It is important to note that child welfare definitions and the administration of child welfare and protective service vary between countries and caution is warranted in the interpretation of variation and change in system contact. Users should read the User’s Guide carefully before using the data.

Investigators: Mikkeline Nielsen, M.Sc., ROCKWOOL Foundation
Alexander F. Roehrkasse, Ph.D., Butler University
Peter Fallesen, Ph.D., Stockholm University and the ROCKWOOL Foundation
Martin Eiermann, Ph.D., Duke University
Christopher Wildeman, Ph.D., Duke University and the ROCKWOOL Foundation
Sarah Sernaker, M.Sc., Duke University
Alexandra Gibbons, Duke University
Adenosine preconditioning attenuates hepatic reperfusion injury in the rat by preventing the down-regulation of endothelial nitric oxide synthase

Background
          Previous work has suggested that in the liver, adenosine preconditioning is mediated by nitric oxide. Whether the endothelial isoform of nitric oxide synthase plays a part in this mechanism has however not yet been investigated.
        
        
          Methods
          Wistar rats were used (6 in each group) – Groups: (1) sham, (2) ischemia-reperfusion, (3) adenosine + ischemia-reperfusion, (4) endothelial isoform inhibitor + adenosine + ischemia-reperfusion.
        
        
          Results
          Using immunohistochemistry, this study has revealed a decrease in the expression of endothelial nitric oxide synthase following hepatic ischemia-reperfusion. This was prevented by adenosine pre-treatment. When an inhibitor of endothelial nitric oxide synthase was administered prior to adenosine pre-treatment, pre-conditioning did not occur despite normal expression of endothelial nitric oxide synthase.
        
        
          Conclusions
          These findings suggest that adenosine attenuates hepatic injury by preventing the downregulation of endothelial nitric oxide synthase that occurs during ischemia-reperfusion.
Compound 526934: 2-Furylmethyl 3-thienyl disulphide

Chemical compound data from PubChem database. IUPAC Name: 2-[(thiophen-3-yldisulfanyl)methyl]furan. Molecular Formula: C9H8OS3. Molecular Weight: 228.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
An efficient method to successively introduce transgenes into a given genomic locus in the mouse

Background
          Expression of transgenes in mice requires transcriptional regulatory elements that direct expression in a chosen cell type. Unfortunately, the availability of well-characterized promoters that direct bona-fide expression of transgenes in transgenic mice is limited. Here we described a method that allows highly efficient targeting of transgenes to a preselected locus in ES cells.
        
        
          Results
          A pgk-LoxP-Neo cassette was introduced into a desired genomic locus by homologous recombination in ES cells. The pgk promoter was then removed from the targeted ES cells by Cre recombinase thereby restoring the ES cells' sensitivity to G418. We demonstrated that transgenes could be efficiently introduced into this genomic locus by reconstituting a functional Neo gene.
        
        
          Conclusion
          This approach is simple and extremely efficient in facilitating the introduction of single-copy transgenes into defined genomic loci. The availability of such an approach greatly enhances the ease of using endogenous regulatory elements to control transgene expression and, in turn, expands the repertoire of elements available for transgene expression.
Provider Network Data: 2025 Quarter 2

This Provider Network Data file contains information on individual providers and institutional providers (i.e., hospitals, labs, home care agencies) participating in health plan networks from April through June 2025. Plan network data is collected from Medicaid, Commercial, and Exchange plans on a quarterly basis by the Department of Health, including Managed Care Organizations (MCOs), Preferred Provider Organizations (PPOs) and Exclusive Provider Organizations (EPOs) plans.

For more information, please visit: <a href=https://pndslookup.health.ny.gov>https://pndslookup.health.ny.gov</a>
Compound 529101: 8-Methyl-4H-pyrido[1,2-a]pyrimidin-4-one

Chemical compound data from PubChem database. IUPAC Name: 8-methylpyrido[1,2-a]pyrimidin-4-one. Molecular Formula: C9H8N2O. Molecular Weight: 160.17. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Embryonic stem cells and mice expressing different GFP variants for multiple non-invasive reporter usage within a single animal

Background
          Non-invasive autofluorescent reporters have revolutionized lineage labeling in an array of different organisms. In recent years green fluorescent protein (GFP) from the bioluminescent jellyfish Aequoria Victoria has gained popularity in mouse transgenic and gene targeting regimes [1]. It offers several advantages over conventional gene-based reporters, such as lacZ and alkaline phosphatase, in that its visualization does not require a chromogenic substrate and can be realized in vivo. We have previously demonstrated the utility and developmental neutrality of enhanced green fluorescent protein (EGFP) in embryonic stem (ES) cells and mice [2].
        
        
          Results
          In this study we have used embryonic stem (ES) cell-mediated transgenesis to test the enhanced cyan fluorescent protein (ECFP) and enhanced yellow fluorescent protein (EYFP), two mutant and spectrally distinct color variants of wild type (wt) GFP. We have also tested DsRed1, the novel red fluorescent protein reporter recently cloned from the Discostoma coral by virtue of its homology to GFP. To this end, we have established lines of ES cells together with viable and fertile mice having widespread expression of either the ECFP or EYFP GFP-variant reporters. However, we were unable to generate equivalent DsRed1 lines, suggesting that DsRed1 is not developmentally neutral or that transgene expression cannot be sustained constitutively. Balanced (diploid <-> diploid) and polarized (tetraploid <-> diploid) chimeras comprising combinations of the ECFP and EYFP ES cells and/or embryos, demonstrate that populations of cells expressing each individual reporter can be distinguished within a single animal.
        
        
          Conclusions
          GFP variant reporters are unique in allowing non-invasive multi-spectral visualization in live samples. The ECFP and EYFP-expressing transgenic ES cells and mice that we have generated provide sources of cells and tissues for combinatorial, double-tagged recombination experiments, chimeras or transplantations.
Compound 528155: Methyl 2-methyl-2-propylpentanoate

Chemical compound data from PubChem database. IUPAC Name: methyl 2-methyl-2-propylpentanoate. Molecular Formula: C10H20O2. Molecular Weight: 172.26. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Medicaid Claims (MAX) - Vision and Eye Health Surveillance

2016-2019. This dataset is a de-identified summary table of prevalence rates for vision and eye health data indicators from the Medicaid Analytic eXtract (MAX) data. Medicaid MAX are a set of de-identified person-level data files with information on Medicaid eligibility, service utilization, diagnoses, and payments. The MAX data contain a convenience sample of claims processed by Medicaid and Children’s Health Insurance Program (CHIP) fee for service and managed care plans.  Not all states are included in MAX in all years, and as of November 2019, 2014 data is the latest available.  Prevalence estimates are stratified by all available combinations of age group, gender, and state.  Detailed information on VEHSS Medicare analyses can be found on the VEHSS Medicaid MAX webpage (cdc.gov/visionhealth/vehss/data/claims/medicaid.html). Information on available Medicare claims data can be found on the ResDac website (www.resdac.org). The VEHSS Medicaid MAX dataset was last updated May 2023.
Compound 530651: p-Toluic acid, tridec-2-ynyl ester

Chemical compound data from PubChem database. IUPAC Name: tridec-2-ynyl 4-methylbenzoate. Molecular Formula: C21H30O2. Molecular Weight: 314.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
N-SUMHSS 2021 Questionnaire

This is the questionnaire for the 2021 National Substance Use and Mental Health Services Survey (N-SUMHSS). The N-SUMHSS is a voluntary annual survey of all active substance use and mental health facilities in the United States, its jurisdictions, and the District of Columbia. This document shows the series of questions mental health and substance abuse treatment facilities were asked for the N-SUMHSS.The survey consists of two introductory questions and four separate modules. Skip patterns in the survey direct participants on relevant modules depending on whether the facility is a substance use treatment facility, a mental health treatment facility, or both.Additionally, facilities operated by the Department of Veteran’s Affairs (VA) were asked to complete additional questions regarding VA services offered.The web questionnaire and other addenda are available as PDF files.
Adolescent standing postural response to backpack loads: a randomised controlled experimental study

Background
          Backpack loads produce changes in standing posture when compared with unloaded posture. Although 'poor' unloaded standing posture has been related to spinal pain, there is little evidence of whether, and how much, exposure to posterior load produces injurious effects on spinal tissue. The objective of this study was to describe the effect on adolescent sagittal plane standing posture of different loads and positions of a common design of school backpack. The underlying study aim was to test the appropriateness of two adult 'rules-of-thumb'-that for postural efficiency, backpacks should be worn high on the spine, and loads should be limited to 10% of body weight.
        
        
          Method
          A randomised controlled experimental study was conducted on 250 adolescents (12–18 years), randomly selected from five South Australian metropolitan high schools. Sagittal view anatomical points were marked on head, neck, shoulder, hip, thigh, knee and ankle. There were nine experimental conditions: combinations of backpack loads (3, 5 or 10% of body weight) and positions (backpack centred at T7, T12 or L3). Sagittal plane photographs were taken of unloaded standing posture (baseline), and standing posture under the experimental conditions. Posture was quantified from the x (horizontal) coordinate of each anatomical point under each experimental condition. Differences in postural response were described, and differences between conditions were determined using Analysis of Variance models.
        
        
          Results
          Neither age nor gender was a significant factor when comparing postural response to backpack loads or conditions. Backpacks positioned at T7 produced the largest forward (horizontal) displacement at all the anatomical points. The horizontal position of all anatomical points increased linearly with load.
        
        
          Conclusion
          There is evidence refuting the 'rule-of-thumb' to carry the backpack high on the back. Typical school backpacks should be positioned with the centre at waist or hip level. There is no evidence for the 10% body weight limit.
Compound 530599: 4-Cyanobenzoic acid, dodec-9-ynyl ester

Chemical compound data from PubChem database. IUPAC Name: dodec-9-ynyl 4-cyanobenzoate. Molecular Formula: C20H25NO2. Molecular Weight: 311.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 525291: 1-Chloro-2-methoxyprop-1-ene

Chemical compound data from PubChem database. IUPAC Name: 1-chloro-2-methoxyprop-1-ene. Molecular Formula: C4H7ClO. Molecular Weight: 106.55. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Plasma proteins in a standardised skin mini-erosion (II): effects of extraction pressure

Background
          A standardised suction technique has been used to sample plasma proteins in dermal interstitial fluid (IF) serially for 5 to 6 days from a suction-induced skin mini-erosion. Increased protein concentrations ascribed to inflammation have been shown from day 1 onward. In this study, we assessed the effect of two different extraction pressures on IF sample composition.
        
        
          Methods
          Total protein concentration and the concentrations of insulin, prealbumin, albumin, transferrin, IgG and alpha-2-macroglobulin were assessed daily in healthy volunteers. Samples were extracted at 50 mmHg and 200 mmHg below the atmospheric.
        
        
          Results
          At 0 h after forming the erosion, mean total IF protein content (relative to plasma) was lower in the samples extracted at -200 mmHg than at -50 mmHg (26 +/-13% (SD) vs 48 +/-9.8%; p < 0.05). There were no significant differences at 24, 48, 72 or 96 h. Of the individual proteins, expressed as area units (AU) for area under the curve (AUC) from 0–96 h, albumin was lower in IF sampled at -200 mmHg (2.49 +/- 0.68 vs 3.08 +/- 0.36 AU; p < 0.05), as was transferrin (1.91 +/- 0.52 vs 2.40 +/- 0.42 AU; p < 0.05). Extraction volumes were significantly higher at -200 mmHg (AUC diff: 60%; p < 0.05).
        
        
          Conclusions
          Samples of IF extracted at 0 h at -200 mmHg contained lower protein concentrations, indicating an increased water fraction and an intact sieve function of the vascular wall. The difference in protein concentration extracted at higher and lower pressure from 24 h onward was less pronounced. Lower pressure should be used to sample substances of greater molecular size.
Network PUF - PY2017

The Network PUF (Ntwrk-PUF) is one of the seven files that make up the Marketplace PUF. The Ntwrk-PUF contains issuer-level data identifying provider network URLs. These data either originate from the Network ID template (i.e., template field), an Excel based form used by issuers to describe their plans in the QHP/SADP application process, or were generated by CCIIO for use in data processing (i.e., system-generated)
Ohio: 2011-2012 NSDUH

This report presents Ohio\'s estimates for 25 measures of substance use and mental health based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.
Child Maltreatment 2017

This report presents national data about child abuse and neglect known to child protective services agencies in the United States during federal fiscal year 2017.

Letter from the Associate Commissioner

Acknowledgements

Summary

CHAPTER 1: Introduction

CHAPTER 2: Reports

CHAPTER 3: Children

CHAPTER 4: Fatalities

CHAPTER 5: Perpetrators

CHAPTER 6: Services

APPENDIX A: CAPTA Data Items

APPENDIX B: Glossary

APPENDIX C: State Characteristics

APPENDIX D: State Commentary

Metadata-only record linking to the original dataset. Open original dataset below.
Compound 528948: Phenol, 2-(1-ethylbutyl)-6-nitro

Chemical compound data from PubChem database. IUPAC Name: 2-hexan-3-yl-6-nitrophenol. Molecular Formula: C12H17NO3. Molecular Weight: 223.27. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Stratum corneum lipids liposomes for the topical delivery of 5-aminolevulinic acid in photodynamic therapy of skin cancer: preparation and in vitro permeation study

Background
          Photodynamic therapy (PDT) using 5-aminolevulinic acid (5-ALA) is a skin cancer therapy that still has limitations due to the low penetration of this drug into the skin. We have proposed in this work a delivery system for 5-ALA based on liposomes having lipid composition similar to the mammalian stratum corneum (SCLLs) in order to optimize its skin delivery in Photodynamic Therapy (PDT) of skin cancers.
        
        
          Methods
          SCLLs were obtained by reverse phase evaporation technique and size distribution of the vesicles was determinated by photon correlation spectroscopy. In vitro permeation profile was characterized using hairless mouse skin mounted in modified Franz diffusion cell.
        
        
          Results
          Size exclusion chromatography on gel filtration confirmed vesicle formation. SCLLs obtained by presented a degree of encapsulation of 5-ALA around 5.7%. A distribution of vesicle size centering at around 500 nm and 400 nm respectively for SCLLs and SCLLs containing 5-ALA was found. In vitro 5-ALA permeation study showed that SCLLs preparations presented higher skin retention significantly (p < 0.05) on the epidermis without SC + dermis, with a decreasing of skin permeation compared to aqueous solution.
        
        
          Conclusions
          The in vitro delivery performance provided by SCLLs lead to consider this systems adequate for the 5-ALA-PDT of skin cancer, since SCLLs have delivered 5-ALA to the target skin layers (viable epidermis + dermis) to be treated by topical PDT of skin cancer.
Ferric carboxymaltose injection

Injectafer (ferric carboxymaltose) is an intravenous iron supplement used to treat iron deficiency anemia in adults. It's administered by healthcare professionals through a vein in various doses, such as 100mg, 500mg, 750mg, or 1g of iron. Manufactured by American Regent, Inc., it's a prescription drug approved for replenishing iron stores in the body. This information was generated using AI and is provided for informational and research purposes only.
Norepinephrine-evoked pain in fibromyalgia. A randomized pilot study [ISRCTN70707830]

Background
          Fibromyalgia syndrome displays sympathetically maintained pain features such as frequent post-traumatic onset and stimuli-independent pain accompanied by allodynia and paresthesias. Heart rate variability studies showed that fibromyalgia patients have changes consistent with ongoing sympathetic hyperactivity. Norepinephrine-evoked pain test is used to assess sympathetically maintained pain syndromes. Our objective was to define if fibromyalgia patients have norepinephrine-evoked pain.
        
        
          Methods
          Prospective double blind controlled study. Participants: Twenty FM patients, and two age/sex matched control groups; 20 rheumatoid arthritis patients and 20 healthy controls. Ten micrograms of norepinephrine diluted in 0.1 ml of saline solution were injected in a forearm. The contrasting substance, 0.1 ml of saline solution alone, was injected in the opposite forearm. Maximum local pain elicited during the 5 minutes post-injection was graded on a visual analog scale (VAS). Norepinephrine-evoked pain was diagnosed when norepinephrine injection induced greater pain than placebo injection. Intensity of norepinephrine-evoked pain was calculated as the difference between norepinephrine minus placebo-induced VAS scores.
        
        
          Results
          Norepinephrine-evoked pain was seen in 80 % of FM patients (95% confidence intervals 56.3 – 94.3%), in 30 % of rheumatoid arthritis patients and in 30 % of healthy controls (95% confidence intervals 11.9 – 54.3) (p < 0.05). Intensity of norepinephrine-evoked pain was greater in FM patients (mean ± SD 2.5 ± 2.5) when compared to rheumatoid arthritis patients (0.3 ± 0.7), and healthy controls (0.3 ± 0.8) p < 0.0001.
        
        
          Conclusions
          Fibromyalgia patients have norepinephrine-evoked pain. This finding supports the hypothesis that fibromyalgia may be a sympathetically maintained pain syndrome.
Patent AT-E400804-T1: [Translated] METHOD FOR ANALYZING A SCATTERING SAMPLE BY TIME-RESOLVED MEASUREMENT

A method for analyzing a diffusing sample comprises steps of: a) illuminating the sample with temporally coherent and wavelength-modulated incident light beam; b) producing a succession of interference signals with the diffuse light; c) combining each interference signal with a reference signal (Ref(t,tau<SUB>0</SUB>)) generating a time port; d) extracting the continuous component of each signal characteristic of the predetermined delay (tau<SUB>0</SUB>) derived form c); applying a nonlinear function on each of the continuous components of the signals characterizing the predetermined delay (tau<SUB>0</SUB>); and f) averaging each of the images, with the non-linear function, of the continuous components of the signals characterizing the predetermined delay (tau<SUB>0</SUB>). The invention is useful for observing organs of the human body.
Compound 525795: N-(3-methylphenyl)-N'-(3-chlorophenyl)formamidine

Chemical compound data from PubChem database. IUPAC Name: N'-(3-chlorophenyl)-N-(3-methylphenyl)methanimidamide. Molecular Formula: C14H13ClN2. Molecular Weight: 244.72. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.