AndreaBozzo/ceres-open-data-index huggingface dataset:
PLACES: Census Tract Data (GIS Friendly Format), 2021 release

This dataset contains model-based census tract level estimates for the PLACES 2021 release in GIS-friendly format. PLACES is the expansion of the original 500 Cities project and covers the entire United States—50 states and the District of Columbia (DC)—at county, place, census tract, and ZIP Code Tabulation Area (ZCTA) levels. It represents a first-of-its kind effort to release information uniformly on this large scale for local areas at 4 geographic levels. Estimates were provided by the Centers for Disease Control and Prevention (CDC), Division of Population Health, Epidemiology and Surveillance Branch. PLACES was funded by the Robert Wood Johnson Foundation (RWJF) in conjunction with the CDC Foundation. Data sources used to generate these model-based estimates include Behavioral Risk Factor Surveillance System (BRFSS) 2019 or 2018 data, Census Bureau 2010 population estimates, and American Community Survey (ACS) 2015–2019 or 2014–2018 estimates. The 2021 release uses 2019 BRFSS data for 22 measures and 2018 BRFSS data for 7 measures (all teeth lost, dental visits, mammograms, cervical cancer screening, colorectal cancer screening, core preventive services among older adults, and sleeping less than 7 hours a night). Seven measures are based on the 2018 BRFSS data because the relevant questions are only asked every other year in the BRFSS. These data can be joined with the census tract 2015 boundary file in a GIS system to produce maps for 29 measures at the census tract level. An ArcGIS Online feature service is also available for users to make maps online or to add data to desktop GIS software. 
https://cdcarcgis.maps.arcgis.com/home/item.html?id=024cf3f6f59e49fe8c70e0e5410fe3cf
New York Forward COVID-19 Daily Hospitalization Summary by Region (Archived)

<b>Note:</b> This dataset was archived on 10/6/23. Statewide hospitalization data is available in the New York State Statewide COVID-19 Hospitalizations and Beds dataset. 

This dataset includes the number of patients hospitalized, and number of patients in the intensive care unit (ICU) among patients with lab-confirmed COVID-19 disease by hospital region and reporting date. The primary goal of publishing this dataset is to provide users with timely information about hospitalizations among patients with lab-confirmed COVID-19 disease.

The data source for this dataset is the daily COVID-19 survey through the New York State Department of Health (NYSDOH) Health Electronic Response Data System (HERDS). Hospitals are required to complete this survey daily and data reflects the number of patients hospitalized and number of patients in the ICU reported by hospitals through the survey each day. These data include NYS resident and non-NYS resident hospitalizations. The information from the survey is used for statewide surveillance, planning, resource allocation, and emergency response activities. Hospitals began reporting for the HERDS COVID-19 survey in mid-March 2020. 

To calculate regional totals, the number of patients hospitalized and number of patients in the ICU are each summed by hospital region and reporting date.

The information in this dataset is updated daily on NY Forward; New York State’s resource for COVID-19 testing, early warning monitoring, and regional daily hospitalization dashboards. More information can be found at forward.ny.gov.
National Directory of Drug and Alcohol Abuse Treatment Facilities - 1996

The National Directory of Drug and Alcohol Abuse Treatment Programs 1996 lists federal, state, local, and private facilities that provide substance abuse treatment services. The directory includes treatment facilities that are licensed, certified, or otherwise approved for inclusion in the directory by their state substance abuse agencies and that responded to the 1995 National Survey of Substance Abuse Treatment Services (N-SSATS). The information about each facility that appears in this directory was provided by that facility in response to the 1995 N-SSATS. The Substance Abuse and Mental Health Services Administration (SAMHSA) conducts the N-SSATS annually.
Characterisation of silent and active genes for a variable large protein of

Background
          We report the characterisation of the variable large protein (vlp) gene expressed by clinical isolate A1 of Borrelia recurrentis; the agent of the life-threatening disease louse-borne relapsing fever.
        
        
          Methods
          The major vlp protein of this isolate was characterised and a DNA probe created. Use of this together with standard molecular methods was used to determine the location of the vlp1B. recurrentis A1 gene in both this and other isolates.
        
        
          Results
          This isolate was found to carry silent and expressed copies of the vlp1B. recurrentis A1 gene on plasmids of 54 kbp and 24 kbp respectively, whereas a different isolate, A17, had only the silent vlp1B. recurrentis A17 on a 54 kbp plasmid. Silent and expressed vlp1 have identical mature protein coding regions but have different 5' regions, both containing different potential lipoprotein leader sequences. Only one form of vlp1 is transcribed in the A1 isolate of B. recurrentis, yet both 5' upstream sequences of this vlp1 gene possess features of bacterial promoters.
        
        
          Conclusion
          Taken together these results suggest that antigenic variation in B. recurrentis may result from recombination of variable large and small protein genes at the junction between lipoprotein leader sequence and mature protein coding region. However, this hypothetical model needs to be validated by further identification of expressed and silent variant protein genes in other B. recurrentis isolates.
Autoantibodies directed to novel components of the PM/Scl complex, the human exosome

The autoantigenic polymyositis/scleroderma (PM/Scl) complex was recently shown to be the human homologue of the yeast exosome, which is an RNA-processing complex. Our aim was to assess whether, in addition to targeting the known autoantigens PM/Scl-100 and PM/Scl-75, autoantibodies also target recently identified components of the PM/Scl complex. The prevalence of autoantibodies directed to six novel human exosome components (hRrp4p, hRrp40p, hRrp41p, hRrp42p, hRrp46p, hCsl4p) was determined in sera from patients with idiopathic inflammatory myopathy (n = 48), scleroderma (n = 11), or the PM/Scl overlap syndrome (n = 10). The sera were analyzed by enzyme-linked immunosorbent assays and western blotting using the affinity-purified recombinant proteins. Our results show that each human exosome component is recognized by autoantibodies. The hRrp4p and hRrp42p components were most frequently targeted. The presence of autoantibodies directed to the novel components of the human exosome was correlated with the presence of the anti-PM/Scl-100 autoantibody in the sera of patients with idiopathic inflammatory myopathy (IIM), as was previously found for the anti-PM/Scl-75 autoantibody. Other clear associations between autoantibody activities were not found. These results further support the conception that the autoimmune response may initially be directed to PM/Scl-100, whereas intermolecular epitope spreading may have caused the autoantibody response directed to the associated components.
Firefighter Body Dimensions for Updating Safety Specifications for Fire Apparatus and Firefighter Protective Equipment

Up-to-date anthropometric information (body dimensions) of the U.S. firefighter population is needed for updating ergonomic and safety specifications for fire apparatus and firefighter protective equipment. Seventy-one measurements relevant to the design of seats, seat belts, cabs, turnout gear, gloves, and head-and-face gear are presented in this webpage. Forty of the 71 measurements were collected with the participants in fitted shorts in both standing and seated postures. Twenty-one of the 71 measurements were collected while the participants were wearing their personal turnout gear, including personal selection of tools stored in their pockets, in both standing and seated postures. Ten of the 71 measurements were hand- and head/face-related dimensions extracted from hand and head/face scans. The data obtained in this study provide the first available U.S. national firefighter anthropometric information which will benefit the design of future fire apparatus and protective equipment to better protect firefi
NNDSS - TABLE 1FF. Severe acute respiratory syndrome-associated coronavirus disease to Shigellosis

Notice: For data on COVID-19 in the United States, please see https://www.cdc.gov/coronavirus/2019-ncov/cases-in-us.html.

Notice: Data from California published in week 29 for years 2019 and 2020 were incomplete when originally published on July 24, 2020. On August 4, 2020, incomplete case counts were replaced with a "U" indicating case counts are not available for specified time period. 

NNDSS - TABLE 1FF. Severe acute respiratory syndrome-associated coronavirus disease to Shigellosis – 2020.  In this Table, provisional cases* of notifiable diseases are displayed for United States, U.S. territories, and Non-U.S. residents.

Note: 
This table contains provisional cases of national notifiable diseases from the National Notifiable Diseases Surveillance System (NNDSS). NNDSS data from the 50 states, New York City, the District of Columbia and the U.S. territories are collated and published weekly on the NNDSS Data and Statistics web page (https://wwwn.cdc.gov/nndss/data-and-statistics.html). Cases reported by state health departments to CDC for weekly publication are provisional because of the time needed to complete case follow-up. Therefore, numbers presented in later weeks may reflect changes made to these counts as additional information becomes available. The national surveillance case definitions used to define a case are available on the NNDSS web site at https://wwwn.cdc.gov/nndss/. Information about the weekly provisional data and guides to interpreting data are available at: https://wwwn.cdc.gov/nndss/infectious-tables.html. 

Footnotes:
U: Unavailable — The reporting jurisdiction was unable to send the data to CDC or CDC was unable to process the data.
-: No reported cases — The reporting jurisdiction did not submit any cases to CDC.
N: Not reportable — The disease or condition was not reportable by law, statute, or regulation in the reporting jurisdiction.
NN: Not nationally notifiable — This condition was not designated as being nationally notifiable.
NP: Nationally notifiable but not published.
NC: Not calculated — There is insufficient data available to support the calculation of this statistic.
Cum: Cumulative year-to-date counts.
Max: Maximum — Maximum case count during the previous 52 weeks.
* Case counts for reporting years 2019 and 2020 are provisional and subject to change. Cases are assigned to the reporting jurisdiction submitting the case to NNDSS, if the case's country of usual residence is the U.S., a U.S. territory, unknown, or null (i.e. country not reported); otherwise, the case is assigned to the 'Non-U.S. Residents' category. Country of usual residence is currently not reported by all jurisdictions or for all conditions. For further information on interpretation of these data, see https://wwwn.cdc.gov/nndss/document/Users_guide_WONDER_tables_cleared_final.pdf.
†Previous 52 week maximum and cumulative YTD are determined from periods of time when the condition was reportable in the jurisdiction (i.e., may be less than 52 weeks of data or incomplete YTD data).
Detection of chromosomes tagged with green fluorescent protein in live

Background
          Structural and dynamic studies of chromosomes tagged with green fluorescent protein (GFP) in yeast and cultured animal cells have revealed some surprises. Although this technology can be very powerful, only a few studies using this approach with developed multicellular systems have been reported for the study of chromatin behavior in situ.
        
        
          Results
          We established vectors and conditions to visualize tagged loci stably inserted in the Arabidopsis genome via GFP fused to a bacterial DNA-binding protein. Using this system, three-dimensional coordinates for tagged loci within nuclei from cells of a live plant can be directly determined with concomitant visualization of the position of the nucleolus. Chromosome polyploidization in epidermal cells at the elongation zone of the root in transgenic plants can be visualized in situ using this technique.
        
        
          Conclusion
          We have established that GFP fusion with DNA-binding proteins can be used in conjunction with concatameric binding-site arrays to track genomic loci in living Arabidopsis plants. It should now be feasible to study the mechanisms of organization and dynamics of chromatin in specific cell types during various times of plant development, taking advantage of the well developed genetic systems and resources available for Arabidopsis.
HAICViz - Candidemia

<p>The healthcare-associated infection component of CDC’s <a href="https://www.cdc.gov/ncezid/dpei/eip/index.html" target="_blank">EIP</a> engages a <a href="https://www.cdc.gov/ncezid/dpei/eip/eip-sites.html" target="_blank">network</a> of state health departments and their academic medical center partners to help answer critical questions about emerging HAI threats, advanced infection tracking methods, and antibiotic resistance in the United States. Information gathered through this activity will play a key role in shaping future policies and recommendations targeting HAI prevention. </p>
Compound 529179: 5-Amino-1-pentanol, TMS derivative

Chemical compound data from PubChem database. IUPAC Name: 5-trimethylsilyloxypentan-1-amine. Molecular Formula: C8H21NOSi. Molecular Weight: 175.34. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 530255: Pentadecane, 7-ethyl-8-methyl

Chemical compound data from PubChem database. IUPAC Name: 7-ethyl-8-methylpentadecane. Molecular Formula: C18H38. Molecular Weight: 254.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Structural and functional aspects of liver sinusoidal endothelial cell fenestrae: a review

This review provides a detailed overview of the current state of knowledge about the ultrastructure and dynamics of liver sinusoidal endothelial fenestrae. Various aspects of liver sinusoidal endothelial fenestrae regarding their structure, origin, species specificity, dynamics and formation will be explored. In addition, the role of liver sinusoidal endothelial fenestrae in relation to lipoprotein metabolism, fibrosis and cancer will be approached.
Patent AT-E4014-T1: [Translated] BROADBAND TELECOMMUNICATION SYSTEM.

1. A wide-band telecommunications system comprising light waveguides (LWL) between exchange stations (VSt) and subscribers (Tin), on each of which a plurality of video signals, radio channels and digital signal unit channels, in particular 64-kbit/s channels of an integrated digital telecommunications network can be combined in multiplex fashion, a respective opto/electronic transducer (O/E) is connected to the light waveguide (LWL) at the subscriber end, and to which opto/electro-transducer a de-multiplexer (Dex)/multiplexer (Mul) is possibly connected in order to separate/combine digital signals, which are transmitted in digital telecommunications network unit channels, from/with the video and radio signals and feedback channel signals, characterised in that the video signals are transmitted on the light waveguide (LWL) and on a coaxial line (KL), which is provided for each individual domestic unit, which is to be used for video and radio signals, and which leads to one or more sockets (D1...Dn) having separate jacks for video and radio signals, in the transmission channels which are individually assigned to the individual video receivers which are currently operated on the coaxial line (KL), only the video signals determined for a video receiver (TVEi) operated at a random socket (Dn) of the coaxial line (KL) are rendered operative by an individual receiver-adjusted channel selection device in the particular video receiver (TVEi).
Patent AT-E400367-T1: [Translated] MEASURING THE MANUAL OPERATION OF SPRAYERS

An assembly that provides operational information about operation of a device, such as a nasal spray pump or metered dose inhaler. A linkage adapted to extend between a mounting assembly, connected to a stationary part of the device, and an adapter assembly, connected to a movable part of the device, is in operational relationship with a transducer to enable the transducer to indicate a mechanical relationship between the movable and stationary parts of the device corresponding to the operation of the device. A data collection and processing system may be connected to the transducer for determining information that may be used to program an automated actuation system.
Alabama (AL)

This report uses 2008 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past year alcohol use disorder and illicit drug use disorder among persons aged 12 or older for Alabama overall and for substate regions within Alabama. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE).
2016 National Survey on Drug Use and Health:  Methodological Summary and Definitions

This report summarizes methods and other supporting information that are relevant to estimates of substance use and mental health issues from the 2016 National Survey on Drug Use and Health (NSDUH), an annual survey of the civilian, noninstitutionalized population of the United States aged 12 years old or older. NSDUH is the primary source of statistical information on the use of tobacco, alcohol, prescription psychotherapeutic drugs (pain relievers, tranquilizers, stimulants, and sedatives), and other substances (e.g., marijuana, cocaine) by the U.S. civilian, noninstitutionalized population aged 12 or older. The survey also includes several series of questions that focus on mental health issues.
A ~35 kDa polypeptide from insect cells binds to yeast ACS like elements in the presence of ATP

Background
          The S. cerevisiae origin recognition complex binds to the ARS consensus sequence in an ATP dependent fashion. Recently, the yeast Cdc6 has been reported to have DNA binding activity. Conservation of replication proteins among different species strongly supports their functional similarity. Here we report the results of an investigation into the DNA binding activity of human Cdc6 protein. Cdc6 was expressed and purified from baculovirus infected Sf9 (Spodoptera frugiperda) insect cells as GST fusion protein (GST-Cdc6) and its DNA binding activity was tested.
        
        
          Results
          Partially purified fractions containing GSTCdc6 or GST showed an ACS binding activity in an ATP dependent manner. However, further purification revealed the presence of a putative 35 kDa insect cell protein (p35) which was found responsible for the DNA binding activity. A close match to the 9/11 bases of the ARS consensus sequence was sufficient for p35 binding activity. A DNA fragment from the human c-myc origin region containing yeast ACS like elements also showed p35 binding activity.
        
        
          Conclusions
          We have identified a Spodoptera frugiperda protein with ATP dependent DNA binding activity to ACS like elements. ACS like elements have been reported to be essential for ORC binding and replication initiation in yeast but their role in higher eukaryotes still remains elusive. Like the ARS consensus sequence elements of yeast, ACS like elements found in c-myc and lamin beta 2 origin regions may play similar roles in replication and indicate a conserved role for this DNA motif among eukaryotes.
Metoprolol tartrate and hydrochlorothiazide

Lopressor HCT is a prescription medication combining metoprolol tartrate (a beta-blocker) and hydrochlorothiazide (a diuretic) to treat high blood pressure. Available as oral tablets in strengths like 50mg/25mg or 100mg/25mg, it helps lower blood pressure by relaxing blood vessels and reducing fluid buildup. Some formulations are discontinued. This information was generated using AI and is provided for informational and research purposes only.
Norethindrone and ethinyl estradiol

Norethindrone and Ethinyl Estradiol is a generic oral contraceptive pill containing 1 mg norethindrone and 0.035 mg ethinyl estradiol per tablet. It's used to prevent pregnancy by regulating hormones. Packaged in a 28-tablet blister pack for monthly cycles. Manufactured by Naari Pte Limited under ANDA 206864. This information was generated using AI and is provided for informational and research purposes only.
Compound 530365: Silane, [[4-[1,2-bis[(trimethylsilyl)oxy]ethyl]-1,2-phenylene]bis(oxy)]bis[trimethyl-

Chemical compound data from PubChem database. IUPAC Name: [4-[1,2-bis(trimethylsilyloxy)ethyl]-2-trimethylsilyloxyphenoxy]-trimethylsilane. Molecular Formula: C20H42O4Si4. Molecular Weight: 458.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 529634: 4-Methyl-2-propyl-1,3-dithiolane

Chemical compound data from PubChem database. IUPAC Name: 4-methyl-2-propyl-1,3-dithiolane. Molecular Formula: C7H14S2. Molecular Weight: 162.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
QHP Landscape PY2023 Medical SHOP

The Medical SHOP Market file of the QHP Landscape Files contains information on certified medical plans offered through an Exchange to employers in the Small Business Health Options Program (SHOP) market. These plans are also known as Qualified Health Plans (QHPs). The file reports plans offered by county for states in the Federally-facilitated Exchanges including states performing plan management functions, and State Based Exchanges using the federal platform for eligibility and enrollment.