AndreaBozzo/ceres-open-data-index huggingface dataset:
"In-gel" purified ditags direct synthesis of highly efficient SAGE Libraries

Background
          SAGE (serial analysis of gene expression) is a recently developed technique for systematic analysis of eukaryotic transcriptomes. The most critical step in the SAGE method is large scale amplification of ditags which are then are concatemerized for the construction of representative SAGE libraries. Here, we report a protocol for purifying these ditags via an 'in situ' PAGE purification method. This generates ditags free of linker contaminations, making library construction simpler and more efficient.
        
        
          Results
          Ditags used to generate SAGE libraries were demarcated 'in situ' on preparative polyacrylamide gels using XC and BPB dyes, which precisely straddle the ditag band when a 16% PAGE gel (19:1 acrylamide:bis, 5% cross linker) is used to resolve the DNA bands. Here, the ditag DNA was directly excised from gel without visualization via EtBr or fluorescent dye staining, resulting in highly purified ditag DNA free of contaminating linkers. These ditags could be rapidly self ligated even at 4°C to generate concatemers in a controlled manner, which in turn enabled us to generate highly efficient SAGE libraries. This reduced the labor and time necessary, as well as the cost.
        
        
          Conclusions
          This approach greatly simplified the ditag purification procedure for constructing SAGE libraries. Since the traditional post-run staining with EtBr or fluorescent dyes routinely results in cross contamination of a DNA band of interest by other DNA in the gel, the dry gel DNA excision method described here may also be amenable to other molecular biology techniques in which DNA purity is critically important.
Patent AT-E401654-T1: [Translated] SYSTEM WITH A SUPERCONDUCTIVE CABLE

System with a superconductive cable (KA) comprises a cable sheath (S) having a surface enclosed by a cryostatic temperature regulator (KR) and/or a cryostatic temperature regulator having an inner surface completely covered by a sliding layer (10) of a non-abrasive material with a lower friction coefficient than steel. A corresponding sliding layer surrounding the cable sheath is permeable to cooling medium. Preferred Features: The sliding layer is made of bronze. The sliding layer surrounding the cable sheath consists of a bronze sheet with holes wound around the sheath. At least the inner tube (7) of the cryostatic temperature regulator facing the cable sheath is corrugated perpendicularly to its longitudinal direction.
2011 CMHS Uniform Reporting System (URS) Output Tables for Puerto Rico

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2011. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
Patent AT-E400645-T1: [Translated] PROTEIN SECRETION IMPROVED BY OXA1P

The present invention provides methods and compositions for the efficient and enhanced secretion of a protein of interest from a host cell. In specific, proteins are secreted through the Sec-dependent pathway, involving the spoIIIJ and/or yqjG gene product(s). In some embodiments, expression of the spoIIIJ and/or yqjG gene product(s) is modulated by a promoter operably linked to the gene.
Seattle: Drug-Related Emergency Department Visits, 2004-2011 - Illicits (excluding alcohol)

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving illicit drugs for the Seattle metropolitan area, covering 2004-2011. These visits involve the use of drugs that have limited or no therapeutic value and are generally illegal if taken without a prescription. It also includes visits involving the inhalation of substances for their psychoactive properties (e.g., sniffing model airplane glue).
Medical Expenditure Panel Survey (MEPS) Restricted Data Files

<p>Restricted Data Files Available at the Data Centers<br />
Researchers and users with approved research projects can access restricted data files that have not been publicly released for reasons of confidentiality at the AHRQ Data Center in Rockville, Maryland.<br />
Qualified researchers can also access restricted data files through the U.S. Census Research Data Center (RDC) network (<a href="http://www.census.gov/ces/dataproducts/index.html">http://www.census.gov/ces/dataproducts/index.html</a> -- Scroll down the page and click on the Agency for Health Care Research and Quality (AHRQ) link.) For information on the RDC research proposal process and the data sets available, read AHRQ-Census Bureau agreement on access to restricted MEPS data.</p>
National Substance Use and Mental Health Services Survey (N-SUMHSS): 2021 Data on Substance Use and Mental Health Treatment Facilities

This report presents results from the 2021 National Substance Use and Mental Health Services Survey (N-SUMHSS), an annual census of facilities providing substance use and mental health treatment. Conducted by the Substance Abuse and Mental Health Services Administration (SAMHSA), the N-SUMHSS is designed to collect data on the location, characteristics, and utilization of substance use and mental health treatment facilities throughout the United States and its territories.Clickhereto view the 2021 N-SUMHSS Annual Report.
The cohesin complex: sequence homologies, interaction networks and shared motifs

Background:
          Cohesin is a macromolecular complex that links sister chromatids together at the metaphase plate during mitosis. The links are formed during DNA replication and destroyed during the metaphase-to-anaphase transition. In budding yeast, the 14S cohesin complex comprises at least two classes of SMC (structural maintenance of chromosomes) proteins - Smc1 and Smc3 - and two SCC (sister-chromatid cohesion) proteins - Scc1 and Scc3. The exact function of these proteins is unknown.
        
        
          Results:
          Searches of protein sequence databases have revealed new homologs of cohesin proteins. In mouse, Mmip1 (Mad member interacting protein 1) and Smc3 share 99% sequence identity and are products of the same gene. A phylogenetic tree of SMC homologs reveals five families: Smc1, Smc2, Smc3, Smc4 and an ancestral family that includes the sequences from the Archaea and Eubacteria. This ancestral family also includes sequences from eukaryotes. A cohesion interaction network, comprising 17 proteins, has been constructed using two proteomic databases. Genes encoding six proteins in the cohesion network share a common upstream region that includes the MluI cell-cycle box (MCB) element. Pairs of the proteins in this network share common sequence motifs that could represent common structural features such as binding sites. Scc2 shares a motif with Chk1 (kinase checkpoint protein), that comprises part of the serine/threonine protein kinase motif, including the active-site residue.
        
        
          Conclusions:
          We have combined genomic and proteomic data into a comprehensive network of information to reach a better understanding of the function of the cohesin complex. We have identified new SMC homologs, created a new SMC phylogeny and identified shared DNA and protein motifs. The potential for Scc2 to function as a kinase - a hypothesis that needs to be verified experimentally - could provide further evidence for the regulation of sister-chromatid cohesion by phosphorylation mechanisms, which are currently poorly understood.
Mast cell activation and its relation to proinflammatory cytokine
		  production in the rheumatoid lesion

Mast cell (MC) activation in the rheumatoid lesion provides numerous
			 mediators that contribute to inflammatory and degradative processes, especially
			 at sites of cartilage erosion. MC activation in rheumatoid synovial tissue has
			 often been associated with tumour necrosis factor (TNF)-α and interleukin
			 (IL)-1β production by adjacent cell types. By contrast, our in
			 situ and in vitro studies have shown that the production of IL-15
			 was independent of MC activation, and was not related to TNF-α and
			 IL-1β expression. Primary cultures of dissociated rheumatoid synovial
			 cells produced all three proinflammatory cytokines, with production of
			 IL-1β exceeding that of TNF-α, which in turn exceeded that of IL-15.
			 In vitro cultures of synovial macrophages, synovial fibroblasts and
			 articular chondrocytes all produced detectable amounts of free IL-15,
			 macrophages being the most effective.
Chicago Population Counts

Population totals for groupings commonly used in other datasets.

Not all values are available for all years.

Note that because the "Citywide" rows roll up the values from the individual ZIP Codes and the "Age 0-4," "Age 5-11," "Age 12-17," "Age 5+," "Age 18+," and "Age 65+" columns overlap other age categories, as well as each other in some cases, care should be taken in summing values to avoid accidental double-counting. The "Age 5-11" and "Age 12-17" columns only include children who live in households.

Data Sources: U.S. Census Bureau American Community Survey (ACS) 5-year estimates (ZIP Code) and 1-year estimates (Citywide). The U.S. Census Bureau did not release standard 1-year estimates from the 2020 ACS. In 2020 only, 5-year estimates were used for the Citywide estimates.
Rhythmic expression of

Background
          Nocturnin was originally identified by differential display as a circadian clock regulated gene with high expression at night in photoreceptors of the African clawed frog, Xenopus laevis. Although encoding a novel protein, the nocturnin cDNA had strong sequence similarity with a C-terminal domain of the yeast transcription factor CCR4, and with mouse and human ESTs. Since its original identification others have cloned mouse and human homologues of nocturnin/CCR4, and we have cloned a full-length cDNA from mouse retina, along with partial cDNAs from human, cow and chicken. The goal of this study was to determine the temporal pattern of nocturnin mRNA expression in multiple tissues of the mouse.
        
        
          Results
          cDNA sequence analysis revealed a high degree of conservation among vertebrate nocturnin/CCR4 homologues along with a possible homologue in Drosophila. Northern analysis of mRNA in C3H/He and C57/Bl6 mice revealed that the mNoc gene is expressed in a broad range of tissues, with greatest abundance in liver, kidney and testis. mNoc is also expressed in multiple brain regions including suprachiasmatic nucleus and pineal gland. Furthermore, mNoc exhibits circadian rhythmicity of mRNA abundance with peak levels at the time of light offset in the retina, spleen, heart, kidney and liver.
        
        
          Conclusion
          The widespread expression and rhythmicity of mNoc mRNA parallels the widespread expression of other circadian clock genes in mammalian tissues, and suggests that nocturnin plays an important role in clock function or as a circadian clock effector.
NNDSS - Table II. Salmonellosis (excluding typhoid fever and paratyphoid fever) to Shigellosis

NNDSS - Table II. Salmonellosis (excluding typhoid fever and paratyphoid fever) to Shigellosis - 2018. In this Table, provisional cases of selected notifiable diseases (≥1,000 cases reported during the preceding year), and selected low frequency diseases are displayed. The Table includes total number of cases reported in the United States, by region and by states or territory.

Note:

This table contains provisional cases of selected national notifiable diseases from the National Notifiable Diseases Surveillance System (NNDSS). NNDSS data from the 50 states, New York City, the District of Columbia and the U.S. territories are collated and published weekly on the NNDSS Data and Statistics web page (https://wwwn.cdc.gov/nndss/data-and-statistics.html). Cases reported by state health departments to CDC for weekly publication are provisional because of the time needed to complete case follow-up.  Therefore, numbers presented in later weeks may reflect changes made to these counts as additional information becomes available. The national surveillance case definitions used to define a case are available on the NNDSS web site at https://wwwn.cdc.gov/nndss/. Information about the weekly provisional data and guides to interpreting data are available at: https://wwwn.cdc.gov/nndss/infectious-tables.html. 

Footnotes:

C.N.M.I.: Commonwealth of Northern Mariana Islands. 
U: Unavailable. —: No reported cases. N: Not reportable. NA:  Not Available.  NN: Not Nationally Notifiable. NP: Nationally notifiable but not published. Cum: Cumulative year-to-date counts. Med: Median. Max: Maximum. 

* Case counts for reporting years 2017 and 2018 are provisional and subject to change. Data for years 2013 through 2016 are finalized. FoFor further information on interpretation of these data, see http://wwwn.cdc.gov/nndss/document/ProvisionalNationaNotifiableDiseasesSurveillanceData20100927.pdf.  

† Prior to 2018, cases of paratyphoid fever were included as salmonellosis, but beginning in 2018 they are being published as paratyphoid fever (see Table 1).
Compound 527245: 2,2,2-Trichloroethyl nonanoate

Chemical compound data from PubChem database. IUPAC Name: 2,2,2-trichloroethyl nonanoate. Molecular Formula: C11H19Cl3O2. Molecular Weight: 289.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E399825-T1: [Translated] THERMALLY AND ACTINIC RADIATION CURED COATING MATERIALS AND THEIR USE

The invention relates to coating materials that can be cured thermally and by actinic radiation and that comprise (A) at least one binder, selected from the group including the random, alternating and block, linear, branched and comb polyaddition resins and polycondensation resins that can be cured thermally or thermally and by actinic radiation, and (co)polymers of olefinically unsaturated monomers, and (B) 0.01 to 3 % by weight, based on the solid content of the coating material, of at least one additive on the basis of at least one (meth)acrylate (co)polymer, selected from the group including (meth)acrylate (co)polymers of a number average molecular weight of from 4,000 to 100,000 daltons and having a low to high polarity. The invention relates to the use of the inventive coating materials for producing single-layer and multi-layer clearcoats and color- or effect-producing multi-layer coatings or as adhesives and sealing materials.
Compound 528989: Docosane, 1,2-bis(methylthio)

Chemical compound data from PubChem database. IUPAC Name: 1,2-bis(methylsulfanyl)docosane. Molecular Formula: C24H50S2. Molecular Weight: 402.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Motor Vehicle Occupant Death Rate, by Age and Sex, 2012 & 2014, Region 5 - Chicago

Rate of deaths by age/gender (per 100,000 population) for motor vehicle occupants killed in crashes, 2012 & 2014. 2012 Source: Fatality Analysis Reporting System (FARS). 2014 Source: National Highway Traffic Safety Administration's (NHTSA) Fatality Analysis Reporting System (FARS), 2014 Annual Report File Note: Blank cells indicate data are suppressed. Fatality rates based on fewer than 20 deaths are suppressed.
National Household Survey on Drug Abuse (NHSDA-1995)

<p>This series measures the prevalence and correlates of drug use in the United States. The surveys are designed to provide quarterly, as well as annual, estimates. Information is provided on the use of illicit drugs, alcohol, and tobacco among members of United States households aged 12 and older. Questions include age at first use as well as lifetime, annual, and past-month usage for the following drug classes: marijuana, cocaine (and crack), hallucinogens, heroin, inhalants, alcohol, tobacco, anabolic steroids, nonmedical use of prescription drugs including psychotherapeutics, and polysubstance use. Respondents were also asked about substance abuse treatment history, illegal activities, problems resulting from use of drugs, perceptions of the risks involved, personal and family income sources and amounts, need for treatment for drug or alcohol use, criminal record, and needle-sharing. Questions on mental health and access to care, which were introduced in the 1994-B questionnaire (see NATIONAL HOUSEHOLD SURVEY ON DRUG ABUSE, 1994), were retained in this administration of the survey. Demographic data include sex, race, age, ethnicity, marital status, motor vehicle use, educational level, job status, income level, veteran status, and past and current household composition. This study has 1 Data Set.</p>
Compound 530398: N-Trifluoroacetyl amphetamine

Chemical compound data from PubChem database. IUPAC Name: 2,2,2-trifluoro-N-(1-phenylpropan-2-yl)acetamide. Molecular Formula: C11H12F3NO. Molecular Weight: 231.21. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 530270: Pentadecane, 8-ethyl-7-propyl

Chemical compound data from PubChem database. IUPAC Name: 8-ethyl-7-propylpentadecane. Molecular Formula: C20H42. Molecular Weight: 282.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
High frequency of phenotypic deviations in

Background
          The moss Physcomitrella patens is an attractive model system for plant biology and functional genome analysis. It shares many biological features with higher plants but has the unique advantage of an efficient homologous recombination system for its nuclear DNA. This allows precise genetic manipulations and targeted knockouts to study gene function, an approach that due to the very low frequency of targeted recombination events is not routinely possible in any higher plant.
        
        
          Results
          As an important prerequisite for a large-scale gene/function correlation study in this plant, we are establishing a collection of Physcomitrella patens transformants with insertion mutations in most expressed genes. A low-redundancy moss cDNA library was mutagenised in E. coli using a derivative of the transposon Tn1000. The resulting gene-disruption library was then used to transform Physcomitrella. Homologous recombination of the mutagenised cDNA with genomic coding sequences is expected to target insertion events preferentially to expressed genes. An immediate phenotypic analysis of transformants is made possible by the predominance of the haploid gametophytic state in the life cycle of the moss. Among the first 16,203 transformants analysed so far, we observed 2636 plants ( = 16.2%) that differed from the wild-type in a variety of developmental, morphological and physiological characteristics.
        
        
          Conclusions
          The high proportion of phenotypic deviations and the wide range of abnormalities observed among the transformants suggests that mutagenesis by gene-disruption library transformation is a useful strategy to establish a highly diverse population of Physcomitrella patens mutants for functional genome analysis.
Decreased expression of the mannose 6- phosphate/insulin-like growth factor-II receptor promotes growth of human breast cancer cells

Background
          Loss or mutation of the mannose 6-phosphate/insulin-like growth factor-II receptor (M6P/IGF2R) has been found in breast cancer. However, whether or not decreased levels of functional M6P/IGF2R directly contribute to the process of carcinogenesis needs to be further verified by functional studies.
        
        
          Methods
          In this study, using viral and ribozyme strategies we reduced the expression of M6P/IGF2R in human breast cancer cells and then examined the effect on growth and apoptosis of these cells.
        
        
          Results
          Our results showed that infection of MCF-7 cells with the adenovirus carrying a ribozyme targeted against the M6P/IGF2R mRNA dramatically reduced the level of transcripts and the functional activity of M6P/IGF2R in these cells. Accordingly, cells treated with the ribozyme exhibited a higher growth rate and a lower apoptotic index than control cells (infected with a control vector). Furthermore, decreased expression of M6P/IGF2R enhanced IGF-II-induced proliferation and reduced cell susceptibility to TNF-induced apoptosis.
        
        
          Conclusions
          These results suggest that M6P/IGF2R functions as a growth suppressor and its loss or mutation may contribute to development and progression of cancer. This study also demonstrates that adenoviral delivery of the ribozyme provides a useful tool for investigating the role of M6P/IGF2R in regulation of cell growth.
Compound 526303: 1,9-Dibromo-2,3,6,7-tetrachloro-dibenzo-p-dioxin

Chemical compound data from PubChem database. IUPAC Name: 1,9-dibromo-2,3,6,7-tetrachlorodibenzo-p-dioxin. Molecular Formula: C12H2Br2Cl4O2. Molecular Weight: 479.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 525181: Heptyl pentyl isophthalate

Chemical compound data from PubChem database. IUPAC Name: 3-O-heptyl 1-O-pentyl benzene-1,3-dicarboxylate. Molecular Formula: C20H30O4. Molecular Weight: 334.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Hospital Cost Report Audited Data: 2020

This version of the Institutional Cost Report (ICR) has been audited by a Certified Public Accounting Firm. The ICR is a uniform report completed by New York State hospitals to report income, expenses, assets, liabilities, and statistics to the Department of Health (DOH). Under DOH regulations, (Part 86-1.2), Article 28 hospitals are required to file financial and statistical data with DOH annually. The data filed is part of the ICR and is received electronically through a secured network. This data is used to develop Medicaid rates, assist in the formulation of reimbursement methodologies, and analyze trends. For more information, check out: http://www.health.ny.gov/facilities/hospital/index.htm
Compound 530361: Methyl 2-tert-butylcyclohexane-1-carboxylate

Chemical compound data from PubChem database. IUPAC Name: methyl 2-tert-butylcyclohexane-1-carboxylate. Molecular Formula: C12H22O2. Molecular Weight: 198.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Publications Using SAMHSA Data2021 Uniform Reporting System (URS) Table For Virgin Islands

This is the 2021 Uniform Reporting System (URS) Output Tables for Virgin Islands. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.