AndreaBozzo/ceres-open-data-index huggingface dataset:
Debate: When should we intervene in unstable angina - Time for an old look?

Current treatment modalities for patients with acute coronary syndromes center on early diagnosis, risk stratification and, increasingly, early treatment including invasive approaches. The appropriate timing of these invasive modalities in the context of the overall treatment program remains an area of controversy. Specifically, studies in the past recommended a period of medical 'stabilization' while current approaches are considerably more aggressive. The potential hazard of early intervention, in particular, has not properly been weighed against the benefit. This article hopes to provide a framework for examining the appropriate timing of intervention, specifically percutaneous coronary intervention, in acute coronary syndromes.
Supporting Evidence-Based Home Visitation Programs to Prevent Child Abuse and Neglect Project: The Illinois Department of Human Services

Location:

Statewide

Home Visiting Program Selected:

Nurse Family Partnership, Healthy Families America, and Parents as Teachers

Home Visiting Target Population:

Families at risk for child maltreatment, including first-time parents and parents who have recently added a newborn to their family

Project Overview:
The Illinois Department of Human Services will lead development of an integrated state infrastructure to support three evidence-based models of home visitation. Illinois DHS will coordinate with two other state agencies, Illinois Department of Children and Family Services and Illinois State Board of Education, and with service providers and advocacy groups in the state. Grant goals are to: 1) create a successful and sustainable state level collaborative to support Healthy Families Illinois, Parents as Teachers, and Nurse Family Partnership programs; 2) ensure that local home visiting programs are effective in reducing the risk for child abuse or neglect (implemented and operated with fidelity to the original model) through a quality assurance approach that includes training, technical assistance, monitoring, data collection, reporting and credentialing; and 3) conduct a rigorous evaluation to demonstrate that Illinois' home visitation infrastructure is effective and efficient. The evaluation will examine implementation of the state infrastructure, measure improvements in the operation and impact of local programs, and gauge the impact of these programs on parent-child interactions and the occurrence of child maltreatment.

Metadata-only record linking to the original dataset. Open original dataset below.
2013 CMHS Uniform Reporting System (URS) Tables for Florida

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for Florida for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
NNDSS - TABLE 1MM. Viral hemorrhagic fevers, Chapare virus to Ebola virus

NNDSS - TABLE 1MM. Viral hemorrhagic fevers, Chapare virus to Ebola virus – 2022. In this Table, provisional cases* of notifiable diseases are displayed for United States, U.S. territories, and Non-U.S. residents.

Notes:

•	These are weekly cases of selected infectious national notifiable diseases, from the National Notifiable Diseases Surveillance System (NNDSS). NNDSS data reported by the 50 states, New York City, the District of Columbia, and the U.S. territories are collated and published weekly as numbered tables available at https://www.cdc.gov/nndss/data-statistics/index.html. Cases reported by state health departments to CDC for weekly publication are subject to ongoing revision of information and delayed reporting. Therefore, numbers listed in later weeks may reflect changes made to these counts as additional information becomes available. Case counts in the tables are presented as published each week. See also Guide to Interpreting Provisional and Finalized NNDSS Data at https://www.cdc.gov/nndss/docs/Readers-Guide-WONDER-Tables-20210421-508.pdf.
• Notices, errata, and other notes are available in the Notice To Data Users page at https://wonder.cdc.gov/nndss/NTR.html.
•	The list of national notifiable infectious diseases and conditions and their national surveillance case definitions are available at https://ndc.services.cdc.gov/. This list incorporates the Council of State and Territorial Epidemiologists (CSTE) position statements approved by CSTE for national surveillance.

Footnotes:

*Case counts for reporting years 2021 and 2022 are provisional and subject to change. Cases are assigned to the reporting jurisdiction submitting the case to NNDSS, if the case's country of usual residence is the U.S., a U.S. territory, unknown, or null (i.e. country not reported); otherwise, the case is assigned to the 'Non-U.S. Residents' category. Country of usual residence is currently not reported by all jurisdictions or for all conditions. For further information on interpretation of these data, see https://www.cdc.gov/nndss/docs/Readers-Guide-WONDER-Tables-20210421-508.pdf.
†Previous 52 week maximum and cumulative YTD are determined from periods of time when the condition was reportable in the jurisdiction (i.e., may be less than 52 weeks of data or incomplete YTD data).
U: Unavailable — The reporting jurisdiction was unable to send the data to CDC or CDC was unable to process the data.
-: No reported cases — The reporting jurisdiction did not submit any cases to CDC.
N: Not reportable — The disease or condition was not reportable by law, statute, or regulation in the reporting jurisdiction.
NN: Not nationally notifiable — This condition was not designated as being nationally notifiable.
NP: Nationally notifiable but not published.
NC: Not calculated — There is insufficient data available to support the calculation of this statistic.
Cum: Cumulative year-to-date counts.
Max: Maximum — Maximum case count during the previous 52 weeks.
Patent AT-E401798-T1: [Translated] METHOD FOR PRODUCING A FROZEN MARINATED RECONSTITUTED MEAT PRODUCT

An improved method of marinating and reconstituting meat from trims of fish, poultry, pork, beef or the like comprises the steps of freezing the trims, adding marinade to the frozen trims and compressing the frozen trims to a sufficient pressure to lower the freezing point below the temperature of the frozen trims such that the marinade is diffused through the trims and purge is formed on the outer surface of the trims so as to hold the trims together.
State Health IT Policy Levers Activities Catalog

The Health IT State Policy Levers Compendium was developed by the Office of National Coordinator for Health Information Technology (ONC) in coordination with states. It is intended to support state efforts to advance interoperability and can also be used in service of delivery system reform. The Compendium includes a directory of health IT policy levers and nearly 300 examples of how states have used them. The 'Activities Catalog' includes the over 300 documented examples of health IT policy levers in use by states. The catalog data includes the states using the policy lever to promote health IT and advance interoperability, the state's documented activities, and official information source for these activities.
American Indian and Alaska Native Head Start Family and Child Experiences Survey, 2015

The AIAN FACES 2015 study design, engagement with programs, and dissemination efforts reflect advice from members of the AIAN FACES Workgroup, comprising Region XI Head Start directors, researchers, and federal officials. The Head Start Family and Child Experiences Survey (FACES) is a major source of information on Head Start programs and the children and families they serve. Since 1997, FACES has conducted studies in a nationally representative sample of Head Start programs, but has historically not included Region XI (programs operated by federally-recognized tribes), whose programs are designed to serve predominantly American Indian and Alaska Native (AI/AN) children and families. 

<b>Units of Response: </b>Head Start Programs, Head Start Classroom/Teacher, Head Start Children, Head Start Families, Head Start Centers

<b>Type of Data: </b>Evaluation

<b>Tribal Data: </b>Yes

<b>Periodicity: </b>One-time

<b>Demographic Indicators: </b>Disability;Ethnicity;Household Income;Household Size;Housing Status;Indigenous Population;Race;Sex

<b>SORN: </b>https://www.federalregister.gov/documents/2015/04/02/2015-07440/privacy-act-of-1974-system-of-records-notice

<b>Data Use Agreement: </b>Yes

<b>Data Use Agreement Location: </b>https://www.icpsr.umich.edu/web/ICPSR/studies/36804/datadocumentation

<b>Granularity: </b>Classroom;Family;Individual;Program

<b>Spatial: </b>United States

<b>Geocoding: </b>Unavailable
Compound 528896: 2-(1-Hydroxyethyl)-2-phenylglutarimide

Chemical compound data from PubChem database. IUPAC Name: 3-(1-hydroxyethyl)-3-phenylpiperidine-2,6-dione. Molecular Formula: C13H15NO3. Molecular Weight: 233.26. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 529526: Dimethyl 1-cyclopropyl-4-(3-thienyl)-1,4-dihydro-3,5-pyridinedicarboxylate

Chemical compound data from PubChem database. IUPAC Name: [tert-butyl(dimethyl)silyl] 3-[[tert-butyl(dimethyl)silyl]oxy-methylphosphoryl]propanoate. Molecular Formula: C16H37O4PSi2. Molecular Weight: 380.61. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 529165: 6-Amino-1-hexanol, TMS derivative

Chemical compound data from PubChem database. IUPAC Name: 6-trimethylsilyloxyhexan-1-amine. Molecular Formula: C9H23NOSi. Molecular Weight: 189.37. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 525548: N-Benzylidene-3-bromoaniline

Chemical compound data from PubChem database. IUPAC Name: N-(3-bromophenyl)-1-phenylmethanimine. Molecular Formula: C13H10BrN. Molecular Weight: 260.13. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528405: 2-Ethyl-4-methyloxazole

Chemical compound data from PubChem database. IUPAC Name: 2-ethyl-4-methyl-1,3-oxazole. Molecular Formula: C6H9NO. Molecular Weight: 111.14. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Methylation and silencing of the retinoic acid receptor-β2 gene in cervical cancer

Background
          Expression of the retinoic acid receptor β2 (RAR-β2), a putative tumor suppressor gene, is reduced in various human cancers, including squamous cell carcinomas (SCC) of the uterine cervix. The mechanism of the inhibition of RAR-β2 expression remains obscure. We examined whether methylation of RAR-β2 gene could be responsible for this silencing in cervical SCC.
        
        
          Methods
          Expression of RAR-β2 mRNA and methylation status of the 5' region of RAR-β2 gene were examined in 20 matched specimens from patients with cervical SCC and in three cervical cancer cell lines by Northern blot analysis and methylation-specific PCR (MSP) assay or Southern blot analysis respectively.
        
        
          Results
          In 8 out 20 cervical SCC (40%) the levels of RAR-β2 mRNA were decreased or undetectable in comparison with non-neoplastic cervix tissues. All 8 tumors with reduced levels of RAR-β2 mRNA expression showed methylation of the promoter and the first exon expressed in the RAR-β2 transcript. The RAR-β2 gene from non-neoplastic cervical tissues was mostly unmethylated and expressed, but methylated alleles of the gene were found in three samples of the morphologically normal tissues adjacent to the tumors. Three cervical cancer cell lines with extremely low level of RAR-β2 mRNA expression, SiHA, HeLA and CaSki, also showed methylation of this region of the RAR-β2 gene.
        
        
          Conclusions
          These findings suggest that methylation of the 5' region of RAR-β2 gene may contribute to gene silencing and that methylation of this region may be an important and early event in cervical carcinogenesis. These findings may be useful to make retinoids more effective as preventive and therapeutic agents in combination with inhibitors of DNA methylation.
Compound 530780: p-Methoxybenzoic acid, 2-isopropoxyphenyl ester

Chemical compound data from PubChem database. IUPAC Name: (2-propan-2-yloxyphenyl) 4-methoxybenzoate. Molecular Formula: C17H18O4. Molecular Weight: 286.32. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Isotretinoin

Isotretinoin is a prescription retinoid medication available as oral capsules in strengths of 10mg, 20mg, 30mg, and 40mg. Manufactured by Zydus Pharmaceuticals USA Inc. and Zydus Lifesciences Limited, it's used for treating certain skin conditions like severe acne. This generic drug (ANDA211568) was approved for marketing starting September 2023. This information was generated using AI and is provided for informational and research purposes only.
Visual spatial memory is enhanced in female rats (but inhibited in males) by dietary soy phytoestrogens

Background
          In learning and memory tasks, requiring visual spatial memory (VSM), males exhibit superior performance to females (a difference attributed to the hormonal influence of estrogen). This study examined the influence of phytoestrogens (estrogen-like plant compounds) on VSM, utilizing radial arm-maze methods to examine varying aspects of memory. Additionally, brain phytoestrogen, calbindin (CALB), and cyclooxygenase-2 (COX-2) levels were determined.
        
        
          Results
          Female rats receiving lifelong exposure to a high-phytoestrogen containing diet (Phyto-600) acquired the maze faster than females fed a phytoestrogen-free diet (Phyto-free); in males the opposite diet effect was identified. In a separate experiment, at 80 days-of-age, animals fed the Phyto-600 diet lifelong either remained on the Phyto-600 or were changed to the Phyto-free diet until 120 days-of-age. Following the diet change Phyto-600 females outperformed females switched to the Phyto-free diet, while in males the opposite diet effect was identified.
          Furthermore, males fed the Phyto-600 diet had significantly higher phytoestrogen concentrations in a number of brain regions (frontal cortex, amygdala & cerebellum); in frontal cortex, expression of CALB (a neuroprotective calcium-binding protein) decreased while COX-2 (an inducible inflammatory factor prevalent in Alzheimer's disease) increased.
        
        
          Conclusions
          Results suggest that dietary phytoestrogens significantly sex-reversed the normal sexually dimorphic expression of VSM. Specifically, in tasks requiring the use of reference, but not working, memory, VSM was enhanced in females fed the Phyto-600 diet, whereas, in males VSM was inhibited by the same diet. These findings suggest that dietary soy derived phytoestrogens can influence learning and memory and alter the expression of proteins involved in neural protection and inflammation in rats.
NNDSS - TABLE 1II. Tetanus to Trichinellosis

NNDSS - TABLE 1II. Tetanus to Trichinellosis - 2019. In this Table, provisional cases* of notifiable diseases are displayed for United States, U.S. territories, and Non-U.S. residents. 

Note: 
This table contains provisional cases of national notifiable diseases from the National Notifiable Diseases Surveillance System (NNDSS). NNDSS data from the 50 states, New York City, the District of Columbia and the U.S. territories are collated and published weekly on the NNDSS Data and Statistics web page (https://wwwn.cdc.gov/nndss/data-and-statistics.html). Cases reported by state health departments to CDC for weekly publication are provisional because of the time needed to complete case follow-up. Therefore, numbers presented in later weeks may reflect changes made to these counts as additional information becomes available. The national surveillance case definitions used to define a case are available on the NNDSS web site at https://wwwn.cdc.gov/nndss/. Information about the weekly provisional data and guides to interpreting data are available at: https://wwwn.cdc.gov/nndss/infectious-tables.html. 

Footnotes:
U: Unavailable — The reporting jurisdiction was unable to send the data to CDC or CDC was unable to process the data.
-: No reported cases — The reporting jurisdiction did not submit any cases to CDC.
N: Not reportable — The disease or condition was not reportable by law, statute, or regulation in the reporting jurisdiction.
NN: Not nationally notifiable — This condition was not designated as being nationally notifiable.
NP: Nationally notifiable but not published — CDC does not have data because of changes in how conditions are categorized.
Cum: Cumulative year-to-date counts.
Max: Maximum — Maximum case count during the previous 52 weeks.
* Case counts for reporting years 2018 and 2019 are provisional and subject to change. Cases are assigned to the reporting jurisdiction submitting the case to NNDSS, if the case's country of usual residence is the US, a US territory, unknown, or null (i.e. country not reported); otherwise, the case is assigned to the 'Non-US Residents' category. For further information on interpretation of these data, see https://wwwn.cdc.gov/nndss/document/Users_guide_WONDER_tables_cleared_final.pdf. 
† Previous 52 week maximum and cumulative YTD are determined from periods of time when the condition was reportable in the jurisdiction (i.e., may be less than 52 weeks of data or incomplete YTD data).
Patent AT-E400895-T1: [Translated] LOW TEMPERATURE RADIATION IMAGING APPARATUS WITH CUPS BONDING

An x-ray and gamma-ray radiant energy imaging device is disclosed having a temperature sensitive semiconductor detector substrate bump-bonded to a semiconductor CMOS readout substrate. The temperature sensitive, semiconductor detector substrate utilizes Tellurium compound materials, such as CdTe and CdZnTe. The bump bonds are formed of a low-temperature, lead-free binary solder alloy having a melting point between about 100° C. and about 180° C. Also described is a process for forming solder bumps utilizing the low-temperature, lead-free binary solder alloy, to prevent damage to temperature sensitive and potentially brittle detector substrate when assembling the imaging device.
Citalopram

Citalopram is a generic prescription medication, classified as a serotonin reuptake inhibitor, used to treat depression, anxiety disorders, and related conditions. It is available as an oral solution containing 10 mg of citalopram hydrobromide per 5 mL. Manufactured by Chartwell RX, LLC under ANDA 077629. This information was generated using AI and is provided for informational and research purposes only.
National Directory of Drug and Alcohol Abuse Treatment Facilities 2012

The National Directory of Drug and Alcohol Abuse Treatment Programs 2012 lists federal, state, local, and private facilities that provide substance abuse treatment services. The directory includes treatment facilities that are licensed, certified, or otherwise approved for inclusion in the directory by their state substance abuse agencies and that responded to the 2011 National Survey of Substance Abuse Treatment Services (N-SSATS). The information about each facility that appears in this directory was provided by that facility in response to the 2011 N-SSATS. The Substance Abuse and Mental Health Services Administration (SAMHSA) conducts the N-SSATS annually.
Compound 529615: Cyclopentane, 1,2-dimethyl-3-methylene

Chemical compound data from PubChem database. IUPAC Name: 1,2-dimethyl-3-methylidenecyclopentane. Molecular Formula: C8H14. Molecular Weight: 110.2. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Clinical review: Hypertonic saline resuscitation in sepsis

The present review discusses the hemodynamic effects of hypertonic saline in experimental shock and in patients with sepsis. We comment on the mechanisms of action of hypertonic saline, calling upon data in hemorrhagic and septic shock. Specific actions of hypertonic saline in severe sepsis and septic shock are highlighted. Data are available that support potential benefits of hypertonic saline infusion in various aspects of the pathophysiology of sepsis, including tissue hypoperfusion, decreased oxygen consumption, endothelial dysfunction, cardiac depression, and the presence of a broad array of proinflammatory cytokines and various oxidant species. The goal of research in this field is to identify reliable therapies to prevent ischemia and inflammation, and to reduce mortality.
Polyethyleneimine-mediated transfection of cultured postmitotic neurons from rat sympathetic ganglia and adult human retina

Background
          Chemical methods of transfection that have proven successful with cell lines often do not work with primary cultures of neurons. Recent data, however, suggest that linear polymers of the cation polyethyleneimine (PEI) can facilitate the uptake of nucleic acids by neurons. Consequently, we examined the ability of a commercial PEI preparation to allow the introduction of foreign genes into postmitotic mammalian neurons. Sympathetic neurons were obtained from perinatal rat pups and maintained for 5 days in vitro in the absence of nonneuronal cells. Cultures were then transfected with varying amounts of a plasmid encoding either E. coli β-galactosidase or enhanced green fluorescence protein (EGFP) using PEI.
        
        
          Results
          Optimal transfection efficiency was observed with 1 μg/ml of plasmid DNA and 5 μg/ml PEI. Expression of β-galactosidase was both rapid and stable, beginning within 6 hours and lasting for at least 21 days. A maximum yield was obtained within 72 hours with ∼ 9% of the neurons expressing β-galactosidase, as assessed by both histochemistry and antibody staining. Cotransfection of two plasmids encoding reporter genes was achieved. Postmitotic neurons from adult human retinal cultures also demonstrated an ability to take up and express foreign DNA using PEI as a vector.
        
        
          Conclusions
          These data suggest that PEI is a useful agent for the stable expression of plasmid-encoded genes in neuronal cultures.
Compound 525630: N,N-Dimethyl-N'-hexyl-benzamidine

Chemical compound data from PubChem database. IUPAC Name: N'-hexyl-N,N-dimethylbenzenecarboximidamide. Molecular Formula: C15H24N2. Molecular Weight: 232.36. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 525388: 2,6,6-Trimethyl-5-thiaoctane

Chemical compound data from PubChem database. IUPAC Name: 2-methyl-2-(3-methylbutylsulfanyl)butane. Molecular Formula: C10H22S. Molecular Weight: 174.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.