AndreaBozzo/ceres-open-data-index huggingface dataset:
FY 2006 Children's Bureau Discretionary Grant Awards

This document provides a list of Children's Bureau discretionary grants awarded in fiscal year 2006:

Collaboration between TANF and Child Welfare to Improve Child Welfare Program Outcomes (CFDA # 93.556)
Up to $400,000 per year for 5 years

Demonstration Projects in Post-Adoption Services and Marriage Education (CFDA # 93.652) 
Up to $250,000 per year for 5 years

Infant Adoption Awareness Training Program (CFDA # 93.254)
Up to $6,000,000 per year for 5 years for projects of national scope.
Up to $1,500,000 per year for 5 years for smaller regional or local projects.

National Quality Improvement Center on Non-Resident Fathers (CFDA # 93.652)
Up to $1,000,000 per year for 5 years

National Resource Center for Programs Serving Abandoned Infants and Infants at Risk of Abandonment and their Families (CFDA # 93.551)
Up to $900,000 per year for 4 years

Metadata-only record linking to the original dataset. Open original dataset below.
Patent AT-E400862-T1: [Translated] APPLICATIONS FOR RADIO FREQUENCY IDENTIFICATION SYSTEMS

The present invention relates to RFID devices, including handheld RFID devices, and applications for such devices. The devices and applications may be used in connection with items that are associated with an RFID tag, and optionally a magnetic security element. The devices and applications are described with particular reference to library materials such as books, periodicals, and magnetic and optical media.
Compound 527184: 3-Ethyl-5,8a-dimethyl-1,4a,5,6,7,8-hexahydronaphthalen-2-one

Chemical compound data from PubChem database. IUPAC Name: 3-ethyl-5,8a-dimethyl-1,4a,5,6,7,8-hexahydronaphthalen-2-one. Molecular Formula: C14H22O. Molecular Weight: 206.32. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Tobacco Product and Alcohol Use Tables (Prevalence Estimates) - 2.1 to 2.84

These detailed tables are population tobacco and alcohol use totals and prevalence estimates from the 2012 National Survey on Drug Use and Health (NSDUH). Tobacco products include cigarettes, smokeless tobacco, cigars, and pipe tobacco. Alcohol use includes binge and heavy alcohol use. Results are provided for lifetime, past year, and past month use by age group, gender, race/ethnicity, education level, employment status, and geographic area. Comparisons are made between 2012 and 2011.
Preparation of pure and intact

Background
          In host erythrocytes, the malaria parasite must contend with ion and drug transport across three membranes; its own plasma membrane, the parasitophorous membrane and the host plasma membrane. Isolation of pure and intact Plasmodium falciparum plasma membrane would provide a suitable model to elucidate the possible role played by the parasite plasma membrane in ion balance and drug transport.
        
        
          Results
          This study describes a procedure for isolating parasite plasma membrane from P. falciparum-infected erythrocytes. With this method, the trophozoites released by saponin treatment were cleansed of erythrocyte membranes using anti-erythrocyte antibodies fixed to polystyrene beads. These trophozoites were then biotinylated and the parasite plasma membrane was disrupted by nitrogen cavitation. This process allows the membranes to reform into vesicles. The magnetic streptavidin beads bind specifically to the biotinylated parasite plasma membrane vesicles facilitating their recovery with a magnet. These vesicles can then be easily released from the magnetic beads by treatment with dithiotreithol. The parasite plasma membrane showed optimal ATPase activity at 2 mM ATP and 2 mM Mg2+. It was also found that Ca2+ could not substitute for Mg2+ ATPase activity in parasite plasma membranes whereas activity was completely preserved when Mn2+ was used instead of Mg2+. Other nucleoside triphosphates tested were hydrolysed as efficiently as ATP, while the nucleoside monophosphate AMP was not.
        
        
          Conclusions
          We have described the successful isolation of intact P. falciparum plasma membrane vesicles free of contaminating organelles and determined the experimental conditions for optimum ATPase activity.
Clues to the etiology of autoimmune diseases through analysis of immunoglobulin genes

The role of autoantibodies in the etiology of autoimmune diseases remains unclear. However, an examination of the sequences of these autoantibodies can be informative. Antibody sequences that violate constraints normally imposed during ontogeny and during development point to a failure of regulation. The existence of clonally related sequences indicates that production of these antibodies may frequently be driven by self-antigen. A better understanding of the mechanisms that normally constrain the composition of the antibody repertoire and of the nature of the inciting and/or driving antigens may yield new insights into both the pathogenesis and potential treatment of these crippling diseases.
Statistical issues in randomized trials of cancer screening

Background
          The evaluation of randomized trials for cancer screening involves special statistical considerations not found in therapeutic trials. Although some of these issues have been discussed previously, we present important recent and new methodologies.
        
        
          Methods
          Our emphasis is on simple approaches.
        
        
          Results
          We make the following recommendations:
          (1) Use death from cancer as the primary endpoint, but review death records carefully and report all causes of death
          (2) Use a simple "causal" estimate to adjust for nonattendance and contamination occurring immediately after randomization
          (3) Use a simple adaptive estimate to adjust for dilution in follow-up after the last screen
        
        
          Conclusion
          The proposed guidelines combine recent methodological work on screening endpoints and noncompliance/contamination with a new adaptive method to adjust for dilution in a study where follow-up continues after the last screen. These guidelines ensure good practice in the design and analysis of randomized trials of cancer screening.
Complex trait analysis of the mouse striatum: independent QTLs modulate volume and neuron number

Background
          The striatum plays a pivotal role in modulating motor activity and higher cognitive function. We analyzed variation in striatal volume and neuron number in mice and initiated a complex trait analysis to discover polymorphic genes that modulate the structure of the basal ganglia.
        
        
          Results
          Brain weight, brain and striatal volume, neuron-packing density and number were estimated bilaterally using unbiased stereological procedures in five inbred strains (A/J, C57BL/6J, DBA/2J, BALB/cJ, and BXD5) and an F2 intercross between A/J and BXD5. Striatal volume ranged from 20 to 37 mm3. Neuron-packing density ranged from approximately 50,000 to 100,000 neurons/mm3, and the striatal neuron population ranged from 1.4 to 2.5 million. Inbred animals with larger brains had larger striata but lower neuron-packing density resulting in a narrow range of average neuron populations. In contrast, there was a strong positive correlation between volume and neuron number among intercross progeny. We mapped two quantitative trait loci (QTLs) with selective effects on striatal architecture. Bsc10a maps to the central region of Chr 10 (LRS of 17.5 near D10Mit186) and has intense effects on striatal volume and moderate effects on brain volume. Stnn19a maps to distal Chr 19 (LRS of 15 at D19Mit123) and is associated with differences of up to 400,000 neurons among animals.
        
        
          Conclusion
          We have discovered remarkable numerical and volumetric variation in the mouse striatum, and we have been able to map two QTLs that modulate independent anatomic parameters.
Identification of protein tyrosine phosphatase 1B and casein as substrates for 124-v-Mos

Background
          The mos proto-oncogene encodes a cytoplasmic serine/threonine-specific protein kinase with crucial function during meiotic cell division in vertebrates. Based on oncogenic amino acid substitutions the viral derivative, 124-v-Mos, displays constitutive protein kinase activity and functions independent of unknown upstream effectors of mos protein kinase. We have utilized this property of 124-v-Mos and screened for novel mos substrates in immunocomplex kinase assays in vitro.
        
        
          Results
          We generated recombinant 124-v-Mos using the baculovirus expression system in Spodoptera frugiperda cells and demonstrated constitutive kinase activity by the ability of 124-v-Mos to auto-phosphorylate and to phosphorylate vimentin, a known substrate of c-Mos. Using this approach we analyzed a panel of acidic and basic substrates in immunocomplex protein kinase assays and identified novel in vitro substrates for 124-v-Mos, the protein tyrosine phosphatase 1B (PTP1B), alpha-casein and beta-casein. We controlled mos-specific phosphorylation of PTP1B and casein in comparative assays using a synthetic kinase-inactive 124-v-Mos mutant and further, tryptic digests of mos-phosphorylated beta-casein identified a phosphopeptide specifically targeted by wild-type 124-v-Mos. Two-dimensional phosphoamino acid analyses showed that 124-v-mos targets serine and threonine residues for phosphorylation in casein at a 1:1 ratio but auto-phosphorylation occurs predominantly on serine residues.
        
        
          Conclusion
          The mos substrates identified in this study represent a basis to approach the identification of the mos-consensus phosphorylation motif, important for the development of specific inhibitors of the Mos protein kinase.
Compound 525844: N,N-Dimethyl-N'-pentyl-propionamidine

Chemical compound data from PubChem database. IUPAC Name: N,N-dimethyl-N'-pentylpropanimidamide. Molecular Formula: C10H22N2. Molecular Weight: 170.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E400572-T1: [Translated] METHOD FOR PRODUCING ROSIGLITAZONE

A method for the preparation of rosiglitazone of formula (I) by reduction of 5-[4-[2-(N-methyl- N-(2-?yridyl)amino)ethoxy]-benzylidene]thiazolidine-2,4-dione of formula (II), the reduction being carried out using at least one borohydride of general formula MBH<sub
Licensed Home Care Services Agency Registration Status: 2023

This dataset contains the registration status of each Licensed Home Care Services Agency (LHCSA) in New York State for calendar year 2023. Each LHCSA must register with the New York State Department of Health annually in order to provide services, bill, and avoid paying a fine.

For more information, visit: https://profiles.health.ny.gov/home_care/pages/lhcsa
Preoperative Acute Normovolaemic Hemodilution (ANH) in combination with Hypotensive Epidural Anaesthesia (HEA) during knee arthroplasty surgery. No effect on transfusion rate. A randomized controlled trial [ISRCTN87597684]

Background
          Hypotensive epidural anaesthesia (HEA) combines a high epidural anaesthesia, performing a sympathetic blockade, with low-dose iv-infusion of epinephrine to stabilize circulation in the conscious patient. Mean artery blood pressure is reduced to 45–50 mmHg and hereby a reduced blood loss. In this study we have combined HEA with preoperative acute normovolaemic hemodilution (ANH) in attempt to further reduce the blood loss and need for blood transfusion in total knee arthroplasty surgery (TKR).
        
        
          Methods
          Twenty-eight patients scheduled for TKR are randomised to ANH or no hemodilution (non-ANH). Both groups are anaesthetized with HEA. ANH is established with predonation of 20 % of the total blood volume, and replacement with equal volume of HAES 6 %. Blood re-transfusion is completed within 6 h.
        
        
          Results
          A mean of 877 ml blood was predonated (19.7 % of the total blood volume). Blood loss was, except from the intraoperative loss, significantly higher in ANH group. The total loss was 1306 mL (ANH) vs. 1026 mL (non-ANH), p < 0.05. Except from the first hour postoperatively, hematocrit was identical in between groups postoperatively. The amount of blood transfusion was identical 386 ml (ANH) vs. 343 ml (non-ANH) (ns). 50 % went through surgery without receiving blood (ANH) vs. 58 % (non-ANH). No renal, neurological or cardiopulmonary complications were registered.
        
        
          Conclusions
          These data suggest no benefits in combining HEA and ANH in TKR surgery. Probably because of the reduced viscosity of the blood after ANH, there is an increased postoperative blood loss. The need for homologous blood transfusion was identical.
Immunity status against poliomyelitis in Germany: Determination of cut-off values in International Units

Background
          To prevent importations of wild polioviruses into a polio free region a high level of population immunity must be kept. Standard methodology for determination of polio antibodies is a feature aimed at obtaining consistent results. An International Standard Serum for polio antibodies exists, but no protective level in International Units is defined.
        
        
          Methods
          A representative study was carried out in order to determine the serological status against poliomyelitis in Germany (n = 2564, age 18–79 years). Furthermore, sera from persons aged less than 18 years were included (n = 881). Microneutralization test has been used for determination of antibody levels. Results have been expressed in International Units.
        
        
          Results
          The results of this study indicate that the cut-off level for polio antibodies is 0.075 IU/ml for Polio 1, 0.180 IU/ml for Polio 2 and 0.080 IU/ml for Polio 3. Neutralizing antibodies against poliovirus type 1, 2 and 3 were detected in 96.2%, 96.8% and 89.6% of samples, respectively.
        
        
          Conclusions
          Overall, this seroprevalence indicates a very high level of immunity of the general population. It must be kept after the switch of immunization strategy from attenuated to inactivated vaccine in Germany.
Tizanidine hydrochloride

Tizanidine Hydrochloride is a generic prescription medication that helps relieve muscle spasms caused by conditions like multiple sclerosis or spinal cord injuries. It works as a central alpha-2 adrenergic agonist to relax muscles. Available as oral capsules in 2mg, 4mg, and 6mg strengths, manufactured by Apotex Corp. under ANDA 078868. This information was generated using AI and is provided for informational and research purposes only.
Compound 525255: N''-Butyl-N,N,N',N'-tetramethyl-guanidine

Chemical compound data from PubChem database. IUPAC Name: 2-butyl-1,1,3,3-tetramethylguanidine. Molecular Formula: C9H21N3. Molecular Weight: 171.28. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Elk Creek Seismic Waveforms 2010 (Part 1 of 7)

Coal bursts (damaging seismic events in underground coal mines) pose a substantial threat to operations and mine workers. The underground coal mines in Colorado’s North Fork Valley (NFV) have experienced many coal bursts, often with distinct characteristics from those of other US coal mining regions. To better understand these events and manage their associated risks, the National Institute for Occupational Safety and Health undertook a long-term monitoring campaign at the Elk Creek Mine in the NFV. The monitoring efforts included a seismic network composed of both surface and underground sensors, borehole pressure cells (BPCs), instrumented support Cans, convergence monitors, ground condition surveys, and several other data sources. This dataset consists of the event waveform files from the seismic network for the 983,379 events that were detected during the monitoring campaign. The waveforms are stored in HDF5 files that are broken up by week. Within the HDF5 files, the data are organized by station id, event time, and channel. The amplitudes are velocity in meters/second.
 
This is download 2 of 49 and corresponds to the time range between January 4, 2010, and March 15, 2010.
Compound 526271: 1,3,4-Tribromo-dibenzofuran

Chemical compound data from PubChem database. IUPAC Name: 1,3,4-tribromodibenzofuran. Molecular Formula: C12H5Br3O. Molecular Weight: 404.88. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Zinc sulfate

Zinc Sulfate is an intravenous prescription solution used to treat zinc deficiency, often in patients unable to take it orally. Manufactured by Somerset Therapeutics, LLC, it comes in strengths like 5 mg/mL in 5 mL vials. It works by inhibiting copper absorption and is approved under ANDA216135. This information was generated using AI and is provided for informational and research purposes only.
Vermont: 2011-2012 NSDUH

This report presents Vermont\'s estimates for 25 measures of substance use and mental health based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.
2012 Uniform Reporting System (URS) Tables for Alaska

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2012. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
Compound 528834: Glycerol, 2,3-dimethyl, 1-(12-methyltetradecanoate)

Chemical compound data from PubChem database. IUPAC Name: 2,3-dimethoxypropyl 12-methyltetradecanoate. Molecular Formula: C20H40O4. Molecular Weight: 344.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E399943-T1: [Translated] ROTATION MECHANISM WITH BIAXIAL JOINT AND PORTABLE PHONE WITH IT

A biaxial hinge having a rotating mechanism that realizes durability, a good tactile feedback, smaller size and more lightweight is provided for use in a notebook computer or a portable telephone that needs to be smaller and more lightweight. <??>The biaxial hinge is constituted such that a rotating shaft member 9 is fixed to a rotation support member 10, a rotation-side member 7 is inserted and attached to the outer periphery of the rotating shaft member 9, and an opening/closing torque unit mechanism 12 for opening and closing operations is disposed at the rotation-side member 7, wherein sliding friction torque and click torque are generated by the load produced by a coil spring 6 between pressing members 4 and the rotating shaft support member 10 or a sliding member 3 attached to the rotating shaft member 9. The rotating mechanism of the biaxial hinge of the present invention affords good durability, a good tactile feedback, and a reduction in size and weight. And, this rotating mechanism is applied to a portable telephone. <IMAGE>
Compound 527833: Phenylglycine, butyl ester, TFA

Chemical compound data from PubChem database. IUPAC Name: butyl 2-phenyl-2-[(2,2,2-trifluoroacetyl)amino]acetate. Molecular Formula: C14H16F3NO3. Molecular Weight: 303.28. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Behavioral Health Barometer: Ohio, 2014

This is a behavioral health report for the state of Ohio. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment, and medicare enrollees for the years 2009 to 2013.
Compound 526257: 1,2,8,9-Tetrabromo-4,6-dichloro-dibenzo-p-dioxin

Chemical compound data from PubChem database. IUPAC Name: 1,2,8,9-tetrabromo-4,6-dichlorodibenzo-p-dioxin. Molecular Formula: C12H2Br4Cl2O2. Molecular Weight: 568.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
2010 National Survey of Substance Abuse Treatment Services (N-SSATS) HHS Regional Report

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) regional report that focuses on the rate of clients in treatment for substance abuse in 2010.  There are 10 Department of Health and Human Services regions. The National Survey of Substance Abuse Treatment Services (N-SSATS) is an annual census of facilities in the United States, both public and private, that provide substance abuse treatment.
Post-COVID Conditions

As part of an ongoing partnership with the Census Bureau, the National Center for Health Statistics (NCHS) recently added questions to assess the prevalence of post-COVID-19 conditions (long COVID), on the experimental Household Pulse Survey. This 20-minute online survey was designed to complement the ability of the federal statistical system to rapidly respond and provide relevant information about the impact of the coronavirus pandemic in the U.S. Data collection began on April 23, 2020. Beginning in Phase 3.5 (on June 1, 2022), NCHS included questions about the presence of symptoms of COVID that lasted three months or longer. Phase 3.5 will continue with a two-weeks on, two-weeks off collection and dissemination approach. 

Estimates on this page are derived from the Household Pulse Survey and show the percentage of adults aged 18 and over who a) as a proportion of the U.S. population, the percentage of adults who EVER experienced post-COVID conditions (long COVID). These adults had COVID and had some symptoms that lasted three months or longer; b) as a proportion of adults who said they ever had COVID, the percentage who EVER experienced post-COVID conditions; c) as a proportion of the U.S. population, the percentage of adults who are CURRENTLY experiencing post-COVID conditions. These adults had COVID, had long-term symptoms, and are still experiencing symptoms; d) as a proportion of adults who said they ever had COVID, the percentage who are CURRENTLY experiencing post-COVID conditions; and e) as a proportion of the U.S. population, the percentage of adults who said they ever had COVID.