AndreaBozzo/ceres-open-data-index huggingface dataset:
Estrogen protects against the synergistic toxicity by HIV proteins, methamphetamine and cocaine

Background
          Human immunodeficiency virus (HIV) infection continues to increase at alarming rates in drug abusers, especially in women. Drugs of abuse can cause long-lasting damage to the brain and HIV infection frequently leads to a dementing illness.To determine how these drugs interact with HIV to cause CNS damage, we used an in vitro human neuronal culture characterized for the presence of dopaminergic receptors, transporters and estrogen receptors. We determined the combined effects of dopaminergic drugs, methamphetamine, or cocaine with neurotoxic HIV proteins, gp120 and Tat.
        
        
          Results
          Acute exposure to these substances resulted in synergistic neurotoxic responses as measured by changes in mitochondrial membrane potential and neuronal cell death. Neurotoxicity occurred in a sub-population of neurons. Importantly, the presence of 17beta-estradiol prevented these synergistic neurotoxicities and the neuroprotective effects were partly mediated by estrogen receptors.
        
        
          Conclusion
          Our observations suggest that methamphetamine and cocaine may affect the course of HIV dementia, and additionally suggest that estrogens modify the HIV-drug interactions.
Patent AT-E400541-T1: [Translated] METHOD FOR INCREASE YIELD IN THE PRODUCTION OF VALUE ALCOHOLS BY CLIPING BY-PRODUCTS CONTAINING ACETAL

The invention relates to a method for increasing yield in the production of polyvalent alcohols, especially trimethylolpropane, obtained by condensing formaldehyde with a higher aldehyde. According to the inventive method, acid treatment is carried out on a mixture (high-boiling fraction) that is obtained by reprocessing, contains derivatives of said alcohols and has a higher boiling point than the respective alcohol, and the polyvalent alcohol is recovered from the acid-treated high-boiling fraction. The inventive method is characterised in that the water content of the high-boiling fraction amounts to between 20 and 90 wt. % in relation to the entire mixture of the high-boiling fraction and water.
Compound 526772: 10-Hydroxy-nonadecanoic, methyl ester, tBDMS ether

Chemical compound data from PubChem database. IUPAC Name: methyl 10-[tert-butyl(dimethyl)silyl]oxynonadecanoate. Molecular Formula: C26H54O3Si. Molecular Weight: 442.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 525343: 2,2,4,5-Tetramethyl-3-thiahexane

Chemical compound data from PubChem database. IUPAC Name: 2-tert-butylsulfanyl-3-methylbutane. Molecular Formula: C9H20S. Molecular Weight: 160.32. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 529953: 3-[2-Methyl-(3-thienyldithio)]butan-2-one

Chemical compound data from PubChem database. IUPAC Name: 3-[(2-methylthiophen-3-yl)disulfanyl]butan-2-one. Molecular Formula: C9H12OS3. Molecular Weight: 232.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Analysis of strain and regional variation in gene expression in mouse brain

Background
          We performed a statistical analysis of a previously published set of gene expression microarray data from six different brain regions in two mouse strains. In the previous analysis, 24 genes showing expression differences between the strains and about 240 genes with regional differences in expression were identified. Like many gene expression studies, that analysis relied primarily on ad hoc 'fold change' and 'absent/present' criteria to select genes. To determine whether statistically motivated methods would give a more sensitive and selective analysis of gene expression patterns in the brain, we decided to use analysis of variance (ANOVA) and feature selection methods designed to select genes showing strain- or region-dependent patterns of expression.
        
        
          Results
          Our analysis revealed many additional genes that might be involved in behavioral differences between the two mouse strains and functional differences between the six brain regions. Using conservative statistical criteria, we identified at least 63 genes showing strain variation and approximately 600 genes showing regional variation. Unlike ad hoc methods, ours have the additional benefit of ranking the genes by statistical score, permitting further analysis to focus on the most significant. Comparison of our results to the previous studies and to published reports on individual genes show that we achieved high sensitivity while preserving selectivity.
        
        
          Conclusions
          Our results indicate that molecular differences between the strains and regions studied are larger than indicated previously. We conclude that for large complex datasets, ANOVA and feature selection, alone or in combination, are more powerful than methods based on fold-change thresholds and other ad hoc selection criteria.
Patent AT-E400038-T1: [Translated] DOUBLE BAND TRANSPONDER SYSTEM

Transponder system comprising an interrogating device (BOA) and at least one responding device (TAG) in a bi-directional cable-less communication, where the interrogating device (BOA) and the at least one responding device (TAG) are provided with means for communicating through two distinct transmission channels, one channel for the activation, by the interrogating device (BOA), of a responding device (TAG) present in a preset activation area (MFP), the other channel, bi-directional, for data exchanging between the interrogating device (BOA) and a responding device (TAG) positioned within a data exchange area (RFP). <IMAGE>
Humoral immune response to an allogenic foetus in normal fertile women and recurrent aborters

Background
          Several humoral immune factors are responsible for a successful pregnancy. There are a few studies, which demonstrate the role of antipaternal cytotoxic antibodies (APCA) and mixed lymphocyte reaction blocking factor (MLR-Bf) in the maintenance of pregnancy. However, these factors have not been studied in women with history of recurrent spontaneous abortion (RSA). We designed this study to review the role of APCA and MLR-Bf in normal pregnancy as well as in women with a history of RSA.
        
        
          Methods
          One hundred and five women with unexplained recurrent spontaneous abortion were included in the present study. These women were screened for all other known causes of recurrent abortion. We also included 60 normal fertile women, fifteen from each trimester and fifteen women during the post partum period (up to six months). RSA and controls (normal pregnancy) were matched for age, caste, and socio economic background and also for parity. APCA and MLR-Bf were evaluated in all the groups. All women with RSA who conceived during the study period were on follow up.
        
        
          Results
          We have analyzed the status of APCA and MLR-Bf in normal pregnancy (different gestational periods and during post partum), and in women with history of RSA. Our results show that APCA was significantly higher in controls as compared to RSA women. MLR-Bf was directed against the husbands' cells in normal pregnancy and was virtually absent in RSA women.
        
        
          Conclusion
          Our results indicate that there is a significantly low titer of APCA and MLR-Bf in women with recurrent spontaneous abortion. This highlights the role of these factors in the maintenance of successful pregnancy.
2019 N-SSATS State Profiles

These state profiles include data from facilities that reported to N-SSATS for the survey reference date March 29, 2019. The N-SSATS collects data on the location, characteristics, services offered, and number of clients (collected every other year) in treatment at alcohol and drug abuse treatment facilities (public and private) throughout the 50 states, the District of Columbia, U.S. territories, and other jurisdictions.
Compound 529105: 4-Quinazolone, 2,3-diethyl

Chemical compound data from PubChem database. IUPAC Name: 2,3-diethylquinazolin-4-one. Molecular Formula: C12H14N2O. Molecular Weight: 202.25. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528679: 1,4-Dimethyl-2-(1-methylpropyl)benzene

Chemical compound data from PubChem database. IUPAC Name: 2-butan-2-yl-1,4-dimethylbenzene. Molecular Formula: C12H18. Molecular Weight: 162.27. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 525541: 2-(tert-Butyl-dimethyl-silanyloxy)-3-(2-methylpropyl)-quinoxaline

Chemical compound data from PubChem database. IUPAC Name: tert-butyl-dimethyl-[3-(2-methylpropyl)quinoxalin-2-yl]oxysilane. Molecular Formula: C18H28N2OSi. Molecular Weight: 316.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 529313: Oxetane, 3-ethyl-3-propyl

Chemical compound data from PubChem database. IUPAC Name: 3-ethyl-3-propyloxetane. Molecular Formula: C8H16O. Molecular Weight: 128.21. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Agonizing Hedgehog

It is a rare treat when a drug discovery program teaches us something about the biology of the process that it attempts to modulate. The paper by Maria Frank-Kamenetsky and colleagues in this issue of theJournal of Biology[1] presents a compelling example of how the search for therapeutics can provide powerful experimental tools and insights into fundamental biology, blurring the distinction between applied and basic research. By characterizing a small group of chemically similar agonists of theHedgehogsignaling pathway, Frank-Kamenetskyet al. have been able to propose a new model for how theSmoothenedcomponent of the Hedgehog-receptor complex works, and to hint at the existence of natural-ligand agonists of the Hedgehog signaling pathway (see'The bottom line'box for a summary of their work).
Compound 530618: 5-Chlorovaleric acid, 3-methylbut-2-enyl ester

Chemical compound data from PubChem database. IUPAC Name: 3-methylbut-2-enyl 5-chloropentanoate. Molecular Formula: C10H17ClO2. Molecular Weight: 204.69. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 529239: 3-(Bromomethyl)-3-((2-chlorophenoxy)methyl)oxetane

Chemical compound data from PubChem database. IUPAC Name: 3-(bromomethyl)-3-[(2-chlorophenoxy)methyl]oxetane. Molecular Formula: C11H12BrClO2. Molecular Weight: 291.57. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 527751: 2,2-Dichloroethyl acetate

Chemical compound data from PubChem database. IUPAC Name: 2,2-dichloroethyl acetate. Molecular Formula: C4H6Cl2O2. Molecular Weight: 156.99. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 525130: 2-[3,4-Dimethoxy-2,5-bis(methoxymethyl)oxolan-2-yl]oxy-3,4,5-trimethoxy-6-[[3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxymethyl]oxane

Chemical compound data from PubChem database. IUPAC Name: 2-[3,4-dimethoxy-2,5-bis(methoxymethyl)oxolan-2-yl]oxy-3,4,5-trimethoxy-6-[[3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxymethyl]oxane. Molecular Formula: C29H54O16. Molecular Weight: 658.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 529322: Oxetane, 3-methyl-3-(2-chlorophenyloxy)methyl

Chemical compound data from PubChem database. IUPAC Name: 3-(2-chlorophenoxy)-3-methyloxetane. Molecular Formula: C10H11ClO2. Molecular Weight: 198.64. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 526907: 2-Isobutoxyethyl trifluroacetate

Chemical compound data from PubChem database. IUPAC Name: 2-(2-methylpropoxy)ethyl 2,2,2-trifluoroacetate. Molecular Formula: C8H13F3O3. Molecular Weight: 214.18. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E399519-T1: [Translated] HYDROMASSAGER

It comprises a flattened base (3) for the rest and support of the user, and an articulated covering body (4) with opening and closing means that, with the flattened base (3), define a housing for the positioning of the user in its interior during the treatment, a footing (1) on the ground and a support frame (2) that is characterized in that in the inner part of the body of the apparatus includes a hitting device constituted by a plurality of liquid sprinkler mechanisms (11), placed in at least two horizontal and parallel flatbars (9, 10) or with a certain degree parallelism, equipped with alternative movements in opposite directions one in respect to the other and driven by means of devices (24 to 27) with speed regulation and moving stroke regulation.
CCWIS Strategies: A State Panel Discussion on Progress and Plans to Support Key Initiatives

This state panel discussion addressed how states are approaching planning, development, and technology support for key program initiatives (Qualified Residential Treatment Programs (QRTP), Prevention, and Adoption and Foster Care Analysis and Reporting System (AFCARS)).  Panelists from Florida, Missouri, and Ohio shared updates, progress, and challenges.

Metadata-only record linking to the original dataset. Open original dataset below.
Compound 530581: 2,6-Difluorobenzoic acid, octadecyl ester

Chemical compound data from PubChem database. IUPAC Name: octadecyl 2,6-difluorobenzoate. Molecular Formula: C25H40F2O2. Molecular Weight: 410.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
2013 NSDUH Incidence Tables  (Prevalence Estimates) - 4.1 to 4.16

These detailed tables present totals and prevalence estimates of substance use initiation from the 2013 National Survey on Drug Use and Health (NSDUH). Substances examined include illicit drugs (e.g., marijuana, cocaine, heroin, hallucinogens (including LSD, PCP, Ecstasy), inhalants, and the nonmedical use of prescription-type pain relievers (including OxyContin), tranquilizers, stimulants, sedatives, alcohol, and tobacco products (including cigarettes, smokeless tobacco, and cigars). Results are provided by age group and gender. Estimates are provided for both 2013 and 2012.
Patent AT-E40157-T1: [Translated] SELECTIVE PLATING.

A method of selective plating a component such as a header (3), wherein the header (3) is mounted in a jig (7), a resilient silicone rubber mask (1) having a stepped plating aperture (2) is press fitted to the cap (4) of the header (3) and a beading (12) of the jig (7) so as to expose only the end face of the cap (4) and the ends of the lead wires (5) of the header (3), the assembly is inverted over a plating tank in a selective plating machine, the end face of the cap (4) and the lead wire ends (5) are selectively plated, for example with gold, and the resilient mask (1) is peeled away from the header (3).
Compound 529801: Benzamide, 2-hydroxy, 3-(1-methylethyl), N-methyl

Chemical compound data from PubChem database. IUPAC Name: 2-hydroxy-N-methyl-3-propan-2-ylbenzamide. Molecular Formula: C11H15NO2. Molecular Weight: 193.24. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Role of IL-12 in

The present study demonstrates that endogenous production of IL-12 is crucial for survival in Staphylococcus aureus-induced arthritis in mice. Staphylococcal load is enhanced in several organs, because of lack of IL-12. This might be due to decreased production of IFN-γ in IL-12-deficient mice. Although IL-12-deficient mice were exposed to higher staphylococcal load, they demonstrated no increased severity of arthritis as compared with control animals.
Healthcare Associated Infections - Hospital

The Healthcare-Associated Infection (HAI) measures - provider data. These measures are developed by Centers for Disease Control and Prevention (CDC) and collected through the National Healthcare Safety Network (NHSN). They provide information on infections that occur while the patient is in the hospital. These infections can be related to devices, such as central lines and urinary catheters, or spread from patient to patient after contact with an infected person or surface. Many healthcare associated infections can be prevented when the hospitals use CDC-recommended infection control steps.
Tetracaine hydrochloride

Tetracaine Hydrochloride is a prescription eye drop solution that acts as a local anesthetic to numb the eyes during medical procedures. It contains 0.5% tetracaine hydrochloride and is available in 5 mL or 15 mL bottles. Manufactured by Oceanside Pharmaceuticals under NDA210821. This information was generated using AI and is provided for informational and research purposes only.
Availability of Fiscal Year 2025 Funds Under the Community-Based Grants for the Prevention of Child Abuse and Neglect Program

The purpose of this Program Instruction (PI) is to: (1) set forth the requirements for recipients of Community-Based Grants for the Prevention of Child Abuse and Neglect awards for FY 2025; and (2) provide guidance and instructions for the preparation and submission of the application and annual reports.

Metadata-only record linking to the original dataset. Open original dataset below.
Patent AT-E400223-T1: [Translated] APPLICATOR FOR ATTACHING ANASTOMOSIC RINGS WITH INFLATABLE ELEMENTS

A surgical instrument (10) comprises a handle (19) connected to a shaft (15) and a pair of inflatable members (30,32). The shaft includes conduits (96) for communicating a pressurized medium to the inflatable members and an insufflation tube. The handle includes a port for communicating a pressurized medium to the conduits and a port for communicating a pressurized medium to the insufflation tube. After an anastomotic ring (14) has been deployed, the shaft may be positioned such that an inflatable member is positioned within each of the lumens joined by the anastomosis, such that an inflatable member is located on each side of the anastomosis. The inflatable members may be inflated to provide a seal in each of the lumens. With each of the lumens sealed by the inflatable members, the anastomosis site may be insufflated through the insufflation tube to leak or pressure test the anastomosis.
Compound 527436: 4-Mercapto-3-methyl-pentan-2-one

Chemical compound data from PubChem database. IUPAC Name: 3-methyl-4-sulfanylpentan-2-one. Molecular Formula: C6H12OS. Molecular Weight: 132.23. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
CMS Program Statistics - Medicare Advantage - Physician, Non-Physician Practitioner & Supplier

The CMS Program Statistics – Medicare Advantage, Physician, Non-Physician Practitioner and Supplier tables provide utilization data for physician, non-physician practitioners, and suppliers, by Medicare Advantage beneficiaries.

For additional information on enrollment, providers, and Medicare use and payment, visit the CMS Program Statistics page.


Below is the list of tables:


	MDCR PHYSSUPP MA 1.  Medicare Physicians, Non-Physician Practitioners, and Suppliers: Utilization for Medicare Advantage Beneficiaries, by Type of Entitlement, Yearly Trend
	MDCR PHYSSUPP MA 2.  Medicare Physicians, Non-Physician Practitioners, and Suppliers: Utilization for Medicare Advantage Beneficiaries, by Demographic Characteristics and Medicare-Medicaid Enrollment Status
	MDCR PHYSSUPP MA 3.  Medicare Physicians, Non-Physician Practitioners, and Suppliers: Utilization for Medicare Advantage Beneficiaries, by Area of Residence
	MDCR PHYSSUPP MA 4.  Medicare Physicians, Non-Physician Practitioners, and Suppliers:  Utilization for Medicare Advantage Beneficiaries, by Place of Service
	MDCR PHYSSUPP MA 5.  Medicare Physicians, Non-Physician Practitioners, and Suppliers:  Utilization for Medicare Advantage Beneficiaries, by Restructured BETOS Classification System
Trends in Foster Care and Adoption: FY 2013 – 2022

The data visualization below presents national estimates related to children who experience time in foster care and who are adopted from the foster care system, relative to each Federal Fiscal Year shown. As states are permitted to resubmit AFCARS data, estimates may change over time. This reflects all AFCARS data received as of May 05, 2023 related to AFCARS reporting periods through September 30, 2022.

The national dataset and state data tables are available for download as well.

National Dataset 2013-2022 (XLSX)

State Dataset 2013-2022 (XLSX)

Metadata-only record linking to the original dataset. Open original dataset below.
NOHSS Adult Indicators

2012-2020 (even years). Data from BRFSS for indicators of adult oral health for even years from 2012 through 2020. National estimates are represented by the median prevalence among 50 states and the District of Columbia data. Estimates are prepared from the BRFSS public use data sets. Estimates in this file are not age adjusted, and may differ slightly from estimates available from the BRFSS web site or Chronic Disease Indicators due to small differences in definition, age adjustment or rounding.  For more information, see: https://www.cdc.gov/oralhealthdata/overview/Adult-Indicators.html.
2014 CMHS Uniform Reporting System (URS) Table for Texas

2014 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Texas. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
Compound 528840: Glycerol, 2,3-dimethyl, 1-(15-methylhexadecanoate)

Chemical compound data from PubChem database. IUPAC Name: 2,3-dimethoxypropyl 15-methylhexadecanoate. Molecular Formula: C22H44O4. Molecular Weight: 372.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.