AndreaBozzo/ceres-open-data-index huggingface dataset:
A surrogate-based approach for post-genomic partner identification

Background
          Modern drug discovery is concerned with identification and validation of novel protein targets from among the 30,000 genes or more postulated to be present in the human genome. While protein-protein interactions may be central to many disease indications, it has been difficult to identify new chemical entities capable of regulating these interactions as either agonists or antagonists.
        
        
          Results
          In this paper, we show that peptide complements (or surrogates) derived from highly diverse random phage display libraries can be used for the identification of the expected natural biological partners for protein and non-protein targets. Our examples include surrogates isolated against both an extracellular secreted protein (TNFβ) and intracellular disease related mRNAs. In each case, surrogates binding to these targets were obtained and found to contain partner information embedded in their amino acid sequences. Furthermore, this information was able to identify the correct biological partners from large human genome databases by rapid and integrated computer based searches.
        
        
          Conclusions
          Modified versions of these surrogates should provide agents capable of modifying the activity of these targets and enable one to study their involvement in specific biological processes as a means of target validation for downstream drug discovery.
Compound 530756: 2,6-Difluorobenzoic acid, 3,5-difluorophenyl ester

Chemical compound data from PubChem database. IUPAC Name: (3,5-difluorophenyl) 2,6-difluorobenzoate. Molecular Formula: C13H6F4O2. Molecular Weight: 270.18. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E400694-T1: [Translated] METHOD FOR PRODUCING TEXTILE PRODUCTS, IN PARTICULAR PATTERNED PRODUCTS, WITH GEOMETRIC OR NON-GEOMETRIC PATTERNS AND PRODUCTS OBTAINED SO

To produce a material with a patterning of a geometric or non-geometric design, it incorporates at least two yarns in a uniform and repeated structure. A given pattern is laid of dye pastes in different colors with a particular affinity for each specific type of yarn. The fabric is produced on a tufting machine, using two bars or more with a relative longitudinal displacement between them. The tufted loops are of the same or different height levels, using the different yarn feeds. The tufted material is stabilized by a conventional coating, and is cut into tiles. The tiles are gathered by an index system at an assembly where dye pastes are applied in an accurate repeat color pattern, using an injection action to deliver the dyes of different colors into accurate locations on to the material surface and into its body mass.
The adverse neuro-developmental effects of postnatal steroids in the preterm infant: a systematic review of RCTs

Background
          Recent reports have raised concerns that postnatal steroids may cause neuro-developmental impairment in preterm infants. This systematic review was performed with the objective of determining whether glucocorticoid therapy, to prevent or treat bronchopulmonary dysplasia, impairs neuro-developmental outcomes in preterm infants.
        
        
          Method
          A systematic review of the literature was performed. Medline was searched and articles retrieved using predefined criteria. Data from randomized controlled trials with adequate neuro-developmental follow up (to at least one year) were entered into a meta-analysis to determine the effects of postnatal treatment of preterm infants with glucocorticoids. Cerebral palsy rates, and neuro-developmental impairment (developmental score more than 2SD below the mean, or cerebral palsy or blindness) were analyzed. The studies were divided into 2 groups according to the extent of contamination of the results by treatment of controls with steroids after the initial study period, those with less than 30% contamination, and those with more than 30% contamination or size of contamination not reported.
        
        
          Results
          Postnatal steroid therapy is associated with an increase in cerebral palsy and neuro-developmental impairment. The studies with less contamination show a greater effect of the steroids, consistent with a real direct toxic effect of steroids on the developing central nervous system. The typical relative risk for the development of cerebral palsy derived from studies with less than 30% contamination is 2.86 (95% CI 1.95, 4.19). The typical relative risk for the development of neuro-developmental disability among followed up infants from studies with less than 30% contamination is 1.66 (95% CI 1.26, 2.19). From this subgroup of studies, the number of premature infants who need to be treated to have one more infant with cerebral palsy (number needed to harm, NNH) is 7; to have one more infant with neuro-developmental impairment the NNH is 11.
        
        
          Conclusions
          Postnatal pharmacologic steroid treatment for prevention or treatment of bronchopulmonary dysplasia is associated with dramatic increases in neuro-developmental impairment. As there is no clear evidence in the literature of long term benefit, their use for this indication should be abandoned.
NCHS Research and Development Survey (RANDS) Round 10 Restricted File

The Research and Development Survey (RANDS) is a series of cross-sectional surveys using probability-sampled commercial survey panels. Some rounds also include non-probability panels. The tenth round of RANDS (RANDS 10) was administered by NORC at the University of Chicago using the AmeriSpeak Panel. A sample also was purchased by NORC from the Cint-Lucid non-probability panel. Data were collected from April 18, 2024 to May 13, 2024. RANDS 10 contained the embedded probe questions and experiments as in previous rounds of RANDS. It included questions on quality of life, social and family connections, diet, physical activity, stress, and sleep. The AmeriSpeak part of RANDS 10 has a known survey sampling design and can be used to produce nationally and sub-nationally representative estimates.
Patent AT-E400826-T1: [Translated] WAVELENGTH CONVERTER, METHOD FOR THE PRODUCTION THEREOF AND PHOTO MULTIPLIER CONTAINING A WAVELENGTH CONVERTER

The present invention relates to a wavelength shifter comprising a supporting structure of solid material and a fluorescent wavelength shifting dye capable to absorb light in the UV range and reemit light in the visible range, the dye being homogeneously distributed therein. According to the present invention the supporting material is a fluoro-thermoplastic material (fluoropolymers) having a very high transmittance in the UV range selected from the group comprising tetrafluoroethylene, hexafluoropropylene, vinylidene fluoride and a polymer of tetrafluoroethylene and ethylene, and the wavelength shifting dye is an organic fluor compound.
Behavioral Health Barometer: Region 1, Volume 7

Explore state and regional data for HHS Region 1 with this user-friendly behavioral health report. It uses data from the 2021-2022 National Surveys on Drug Use and Health (NSDUH). The topics addressed in this report include substance use, substance use disorders, and mental health. Selected estimates are provided for adolescents aged 12 to 17, underage people aged 12 to 20, adults aged 18 or older, and the general population aged 12 or older. Statistical tests compare population percentages of (1) HHS region versus national estimates, (2) state versus national estimates, and (3) state versus HHS region estimates.
2010 State Profile — Ohio

This state profile includes data from facilities in Ohio that reported to N-SSATS for the survey reference date March 31, 2010. Data were collected on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse treatment facilities (both public and private) in Ohio. In Ohio, 373 substance abuse treatment facilities were included in the 2010 N-SSATS, reporting that there were 35,763 clients in substance abuse treatment on March 31, 2010. The survey response rate in Ohio was 92.1%.
Pro/con ethics debate: Should mechanical ventilation be continued to allow for progression to brain death so that organs can be donated?

Organ transplants continue to redefine medical frontiers. Unfortunately, current demand for organs far surpasses availability, waiting lists are long and many people die before the organ they desperately need becomes available. One proposed way to increase organ availability is to admit patients to the ICU with severe neurological injuries, for a trial of therapy. If the injury is irretrievable, discussions would then focus on extending ventilation for potential brain death/organ donation if a prior wish to donate is known or if the substitute decision maker consents. The following debate discusses the ethical dilemmas of waiting for brain death.
Patent AT-E400827-T1: [Translated] METHOD FOR REPRESENTING THE WALKING CONDITIONS OF A RACE TRACK

A method of mapping the going conditions for a racecourse comprises surveying the racecourse soil conductivity over the course using soil conductivity measuring means and mapping the conductivity data produced by the conductivity measuring means according to the locations at which the conductivity data were obtained, so as to produce a map of the racecourse showing variations in soil conductivity. The racecourse is then sectioned along its length so as to produce a series of zones, wherein the variations shown in the soil conductivity map are utilized in choosing the sizes of the zones, the going condition in each zone is determined and a map of the racecourse displaying the going conditions along the racecourse is produced. <IMAGE>
Compound 527304: (1R,4aS,8aR)-6-Isopropyl-8a-methyl-4-methylene-1,2,3,4,4a,5,8,8a-octahydronaphthalen-1-ol

Chemical compound data from PubChem database. IUPAC Name: 8a-methyl-4-methylidene-6-propan-2-yl-1,2,3,4a,5,8-hexahydronaphthalen-1-ol. Molecular Formula: C15H24O. Molecular Weight: 220.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 527259: Bicyclo[3.1.0]hexan-1-ol, 2-methyl-5-(1-methylethyl)-

Chemical compound data from PubChem database. IUPAC Name: 2-methyl-5-propan-2-ylbicyclo[3.1.0]hexan-1-ol. Molecular Formula: C10H18O. Molecular Weight: 154.25. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 526637: 1,4-Anhydro-2,3,5-tri-O-methyl-L-fucitol

Chemical compound data from PubChem database. IUPAC Name: 3,4-dimethoxy-2-(1-methoxyethyl)oxolane. Molecular Formula: C9H18O4. Molecular Weight: 190.24. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528759: Npc125737

Chemical compound data from PubChem database. IUPAC Name: 1,1,7-trimethylspiro[2,3,4a,5,6,7,7a,7b-octahydro-1aH-cyclopropa[e]azulene-4,2'-oxirane]. Molecular Formula: C15H24O. Molecular Weight: 220.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 529688: Trimethyl 4,13-dimethyl-5,13-bis(trimethylsilyloxy)tetracyclo[10.2.1.01,9.03,8]pentadecane-2,4,8-tricarboxylate

Chemical compound data from PubChem database. IUPAC Name: trimethyl 4,13-dimethyl-5,13-bis(trimethylsilyloxy)tetracyclo[10.2.1.01,9.03,8]pentadecane-2,4,8-tricarboxylate. Molecular Formula: C29H50O8Si2. Molecular Weight: 582.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 525234: 7-Hydroxy-acepromazine

Chemical compound data from PubChem database. IUPAC Name: 1-[10-[3-(dimethylamino)propyl]-7-hydroxyphenothiazin-2-yl]ethanone. Molecular Formula: C19H22N2O2S. Molecular Weight: 342.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Program Instruction (PI-11-05)

This Program Instruction (PI) provides information on the availability of Fiscal Year (FY) 2011 Funds under the Community-Based Grants for the Prevention of Child Abuse and Neglect program created by Title II of the Child Abuse Prevention and Treatment Act as amended by Public Law (P.L.) 111-320.

Metadata-only record linking to the original dataset. Open original dataset below.
Compound 528222: ID 690

Chemical compound data from PubChem database. IUPAC Name: 5-(2-chlorophenyl)-1-methyl-7-nitro-3H-1,4-benzodiazepin-2-one. Molecular Formula: C16H12ClN3O3. Molecular Weight: 329.74. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E401078-T1: [Translated] THE USE OF C-KIT INHIBITORS TO PROMOTE HAIR GROWTH

The present invention relates to a method for promoting hair growth, preventing or minimizing hair loss comprising administering a tyrosine kinase inhibitor to a human in a need of such treatment, more particularly a non-toxic, selective and potent c-kit inhibitor. Preferably, said inhibitor is unable to promote death of IL-3 dependent cells cultured in presence of IL-3.
Compound 525669: p-Bromobenzylidene-heptyl-amine

Chemical compound data from PubChem database. IUPAC Name: 1-(4-bromophenyl)-N-heptylmethanimine. Molecular Formula: C14H20BrN. Molecular Weight: 282.22. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 529155: 1-Heptanamine, N-isopropylidene

Chemical compound data from PubChem database. IUPAC Name: N-heptylpropan-2-imine. Molecular Formula: C10H21N. Molecular Weight: 155.28. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
National Survey of Substance Abuse Treatment Services (N-SSATS-2008)

<p>The National Survey of Substance Abuse Treatment Services (N-SSATS) is designed to collect information from all facilities in the United States, both public and private, that provide substance abuse treatment. N-SSATS provides the mechanism for quantifying the dynamic character and composition of the United States substance abuse treatment delivery system. The objectives of N-SSATS are to collect multipurpose data that can be used to assist the Substance Abuse and Mental Health Services Administration (SAMHSA) and state and local governments in assessing the nature and extent of services provided and in forecasting treatment resource requirements, to update SAMHSA's Inventory of Substance Abuse Treatment Services (I-SATS), to analyze general treatment services trends, and to generate the National Directory of Drug and Alcohol Abuse Treatment Programs and its online equivalent, the Substance Abuse Treatment Facility Locator <a href="http://findtreatment.samhsa.gov">http://findtreatment.samhsa.gov</a>.  Data are collected on topics including facility operation, services offered (assessment and pre-treatment, pharmacotherapies, testing, transitional, ancillary), detoxification, primary focus (substance abuse, mental health, both, general health, and other), hotline operation, Opioid Treatment Programs and medication dispensed/prescribed, counseling and therapeutic approaches, languages in which treatment is provided, type of treatment provided, number of clients (total and under age 18), number of beds, types of payment accepted, sliding fee scale, special programs offered, facility accreditation and licensure/certification, and managed care agreements.This study has 1 Data Set.</p>
How to Successfully Administer the National Youth in Transition Database Survey

This video series provides three scenarios that highlight best practices to help inform those working to administer the National Youth in Transition Database (NYTD) survey. Providing young people with a variety of ways to take the survey may help a state increase the survey completion rate. Different states may have different practices, so it is important to research how your state administers the NYTD survey to stay in compliance with your state’s practices.

Scenario 2 demonstrates administering the NYTD survey over the telephone.

Metadata-only record linking to the original dataset. Open original dataset below.
Patent AT-E39965-T1: [Translated] CONCRETE SECURITY WALL.

1. A concrete security wall in the concrete of which armored, strip-shaped elements (3) are casted, each one of those being surrounded on all sides by concrete so that a monolithic concrete structure is present, concrete bridges and armatures (2) existing between edges of the armored elements offset in the direction of the wall thickness, characterized in that between the edges of the armored elements (3) located one behind the other in direction of the wall thickness, gaps are present in the longitudinal direction of the wall in which exist concrete bridges and in which lies transverse armatures (2).
CCWIS Announcements Listserv

The CCWIS_Announcements Listserv is a public listserv anyone can join to receive updates on the implementation of the new Comprehensive Child Welfare Information System (CCWIS) regulations. Note: If you are already a member of the Child Welfare IT Managers Listserv you will already receive all messages related to the new CCWIS regulations and do not need to sign up for this new listserv.

To join the listserv, click the link Subscribe to CCWIS_Announcements, which will open an email addressed to listserv@list.nih.gov with the following fields included in the body of the email: Subscribe CCWIS_ANNOUNCEMENTS FirstName LastName

Complete your registration by substituting your first name for “FirstName” and your last name for “LastName” being sure to leave only a single space between each element. Below is an example of what a completed email should look like:

Subscribe CCWIS_Announcements Jane Doe

Upon sending the email, the listserv will respond with a confirmation link in a response email. Once that link is clicked, the request to subscribe will be processed.

Note: Do not include a subject, greeting, closing, or signature in the body of the message.

In order to unsubscribe from this listserv, do one of the following:

Click the link Unsubscribe from CCWIS_Announcements, which will open an email addressed to listserv@list.nih.gov with the following fields included in the body of the email: Unsubscribe CCWIS_ANNOUNCEMENTS. Complete the request to unsubscribe by sending the email. Below is an example of what a completed email should look like:

Unsubscribe CCWIS_Announcements

Upon sending the email, the listserv will respond with a response email stating that the request has been processed.

Note: Do not include a subject, greeting, closing, or signature in the body of the message.

OR

Locate an email sent from the listserv. At the bottom of the email, the message “To unsubscribe from the CCWIS_ANNOUNCEMENTS list, click the following link” includes a link to unsubscribe from the listserv. To unsubscribe, click the link, which will navigate to the list.nih.gov
  
  

 site. At the bottom of the page, there is an unsubscribe button.

For troubleshooting of any issues, contact Kym Rosen (Kimberly.Rosen@acf.hhs.gov).

Metadata-only record linking to the original dataset. Open original dataset below.
Compound 530575: 2,6-Difluorobenzoic acid, heptyl ester

Chemical compound data from PubChem database. IUPAC Name: heptyl 2,6-difluorobenzoate. Molecular Formula: C14H18F2O2. Molecular Weight: 256.29. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Native Languages Resources

The websites featured in this document provide resources relevant to native languages.

*Photo depicts Fond Du Lac Reservation Business Committee’s “Anishinabemowin Language Immersion Canoe/Jii-man Building Project,” funded through an ANA language grant from 2008-2011.

Native Language Preservation: A Reference Guide for Establishing Archives and Repositories

The ANA Native Language Preservation Reference Guide discusses the importance of language repositories to long-term language preservation efforts.

Spoken First

Spoken First, created and maintained by Falmouth Institute, is a resource for news about American Indian languages. This blog, updated daily, keeps track of language news coming from Native American communities across the country.

Center for Applied Linguistics

The Center for Applied Linguistics is a private, nonprofit organization dedicated to providing a comprehensive range of research-based information, tools, and resources related to language and culture.  The center is a private, nonprofit organization established in 1959 and headquartered in Washington, DC.

The Center for Advanced Research on Language Acquisition Less Commonly Taught Languages

This searchable database allows users to learn where specific Less Commonly Taught Languages (all languages with the exception of English, French, German, and Spanish) are taught in North America.

Our Mother Tongues

The interactive Our Mother Tongues website shares a wealth of information about North America’s indigenous languages.  Each featured language page contains video and audio clips, a snapshot of the language’s status and history, and a user-friendly forum for sharing ideas.

Tribal College Journal of American Indian Higher Education Article for Teachers

This journal article provides a collection of resources for teaching American Indian students.  The resources give a background in Indian education and suggest methods for teaching and integrating American Indian content into traditional subject areas.

Regional Native Language Resources

Metadata-only record linking to the original dataset. Open original dataset below.
Elk Creek Seismic Waveforms 2010 (Part 4 of 7)

Coal bursts (damaging seismic events in underground coal mines) pose a substantial threat to operations and mine workers. The underground coal mines in Colorado’s North Fork Valley (NFV) have experienced many coal bursts, often with distinct characteristics from those of other US coal mining regions. To better understand these events and manage their associated risks, the National Institute for Occupational Safety and Health undertook a long-term monitoring campaign at the Elk Creek Mine in the NFV. The monitoring efforts included a seismic network composed of both surface and underground sensors, borehole pressure cells (BPCs), instrumented support Cans, convergence monitors, ground condition surveys, and several other data sources. This dataset consists of the event waveform files from the seismic network for the 983,379 events that were detected during the monitoring campaign. The waveforms are stored in HDF5 files that are broken up by week. Within the HDF5 files, the data are organized by station id, event time, and channel. The amplitudes are velocity in meters/second.
 
This is download 5 of 48 and corresponds to the time range between November 1, 2010, and November 29, 2010.