AndreaBozzo/ceres-open-data-index huggingface dataset:
Road trips and resources: there is a better way

Background:
          Transport of critically ill patients for diagnostic and/or therapeutic management involves significant consumption of resources. In an effort to improve the delivery of care to these patients and decrease resource utilization, Hill-Rom (Batesville, IN, USA) have developed a self-contained device (CarePorterTM) designed to provide both intensive care unit (ICU) support and transport capability. We hypothesized that the use of the CarePorter when compared with a standard or specialty bed (with transfer to a stretcher) would decrease the number of personnel and time required for transport without altering the current ICU standards of care.
        
        
          Results:
          Over a 3 month period, 35 ventilated patient transports were divided into the following groups: specialty bed to stretcher (n = 13), standard bed (n = 9) and CarePorter (n = 13). The APACHE II score at the time of transport was not different between the groups, nor was the ongoing care being delivered. The CarePorter group had a statistically greater fractional inspiration of oxygen and positive end expiratory pressure, when compared with the other two groups (P < 0.05). The use of the CarePorter device decreased the number of personnel required to transport a patient (2.1 ± 0.3 vs 3.6 ± 0.5 for the standard bed and and 3.2 ± 0.7 for the specialty bed; P = 0.0001). The CarePorter also decreased the number of resources utilized for the preparation of a patient for transport (P = 0.001) when compared to the other groups. This was primarily due to the transfer of patients from specialty beds to a stretcher. Overall respiratory therapy time was also much less with the CarePorter (5.9 ± 5.7 min), when compared with the standard (26 ± 10 min) or specialty bed (22 ± 11 min) (P = 0.0008). In addition, the CarePorter group also had a higher nursing satisfaction score with the overall transport (P = 0.008).
        
        
          Conclusions:
          Use of the CarePorter device resulted in maximization of the delivery of patient care, time savings, significantly improved utilization of escort personnel
Genetic determinants of mammographic density

Background
          Changes in breast density are highly correlated with steroid hormone exposure.
        
        
          Materials and methods
          In a cross-sectional study of 396 Caucasian and African-American women, we evaluated whether polymorphisms in genes involved in steroid hormone biosynthesis and metabolism, CYP17 (T27C), COMT (Val158Met), 17HSDB1 (Ser312Gly) and 3HSDB1 (Asn367Thr), predict mammographic density. We also evaluated whether associations vary by menopausal and hormone replacement therapy status.
        
        
          Results
          We found no strong consistent relationships between polymorphisms in these genes and breast density. African-American women homozygous for the Thr allele of 3HSDB1 had increased density (the absolute difference versus the Asn/Asn genotype was +19.7%; P trend = 0.02), while Caucasian homozygous women had decreased density (-5.1%; P trend = 0.04). Among premenopausal women, carriers of the Ser allele had (not significantly) greater density (versus Gly/Gly genotype: +7.1%; P trend = 0.07). In addition, among current users of hormone replacement therapy, we observed that women with the low-activity Met/Met genotype of COMT had greater breast density (versus the Val/Val genotype: +11.7%; P trend = 0.01).
        
        
          Conclusion
          Additional large studies evaluating these and other candidate breast cancer genes will be required to determine what proportion, if any, of the interindividual differences in breast density are due to underlying genetic variation in genes involved in steroid hormone biosynthesis or metabolism.
Compound 525162: Heptaethylene glycol, monoallyl ether, acetate

Chemical compound data from PubChem database. IUPAC Name: 2-[2-[2-[2-[2-[2-(2-prop-2-enoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl acetate. Molecular Formula: C19H36O9. Molecular Weight: 408.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
2012 Uniform Reporting System (URS) Table for Maine

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2012. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
Patent AT-E401218-T1: [Translated] DEVICE FOR SIGNAL OR POWER TRANSMISSION BETWEEN TERMINAL POINTS

The apparatus comprises several flat ribbon cables (FRC) (10) which are equipped with electrical conductors and which form a wound structure (W). The FRC is arranged within a cassette (K) between two terminals (6,8). The ends of the FRC are connected to contact regions for the purpose of connecting ongoing cables. A pot-like cover made of noise-muffling material is provided to engage around the wound structure and is fitted detachably to a disc-shaped carrier, to accommodate the complete wound structure for its protection during transport and storage.
Methscopolamine bromide

Methscopolamine Bromide is an oral prescription tablet used as an anticholinergic medication to help relieve symptoms of gastrointestinal disorders, such as stomach spasms and excessive acid production. Available in 2.5 mg and 5 mg strengths, it's manufactured by i3 Pharmaceuticals, LLC under application ANDA216786. This information was generated using AI and is provided for informational and research purposes only.
Behavioral Risk Factors: Selected Metropolitan Area Risk Trends (SMART) County Prevalence Data (2011 to 2012)

2011 to 2012. BRFSS SMART County Prevalence combined land line and cell phone data.  The Selected Metropolitan Area Risk Trends (SMART) project uses the Behavioral Risk Factor Surveillance System (BRFSS) to analyze the data of selected counties with 500 or more respondents. BRFSS data can be used to identify emerging health problems, establish and track health objectives, and develop and evaluate public health policies and programs. BRFSS is a continuous, state-based surveillance system that collects information about modifiable risk factors for chronic diseases and other leading causes of death. Data will be updated annually as it becomes available. Detailed information on sampling methodology and quality assurance can be found on the BRFSS website (http://www.cdc.gov/brfss). Methodology: http://www.cdc.gov/brfss/factsheets/pdf/DBS_BRFSS_survey.pdf Glossary: https://chronicdata.cdc.gov/Behavioral-Risk-Factors/Behavioral-Risk-Factor-Surveillance-System-BRFSS-H/iuq5-y9ct
Compound 529883: 2-(2-Furanyl)pyrazine

Chemical compound data from PubChem database. IUPAC Name: 2-(furan-2-yl)pyrazine. Molecular Formula: C8H6N2O. Molecular Weight: 146.15. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
A review of clinical trials in dietary interventions to decrease the incidence of coronary artery disease

Of the associations between dietary elements and coronary artery disease (CAD), the greatest body of evidence deals with the beneficial effect of reducing the dietary intake of saturated fatty acids and cholesterol. Furthermore, it is well established, on the basis of convincing evidence, that reduction in serum total cholesterol results in reduction in coronary morbidity and mortality, as well as in regression of other atherosclerotic manifestations.In fact, dietary intervention studies revealed that it is possible to reduce the incidence of coronary death and nonfatal myocardial infarction, as well as manifestations of atherosclerosis in cerebral and peripheral arteries, by reducing dietary intake of saturated fat and cholesterol. In two recently reported dietary interventions the incidence of coronary events, especially coronary mortality, and total mortality were reduced by increased intake of n-3 long-chain polyunsaturated fatty acids and by a modification of the diet toward a Mediterranean-type diet (rich in α-linolenic acid. In addition to those findings, the potential efficacy of the dietary newcomers phytostanol and phytosterol esters on reducing coronary incidence is discussed in the present review.
2015 CMHS Uniform Reporting System (URS) Table for American Samoa

2015 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for American Samoa. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
NSDUH 2020 Methodological Resource Book (MRB)

Use this collection to provide context for estimates from the National Survey on Drug Use and Health (NSDUH). This collection includes materials used to conduct the survey, reports on how the survey was conducted, and reports on how the data were processed. The Statistical Inference Report details how the data were analyzed for reports and tables, which may be useful for data users looking to do their own analysis.New items are added to the collection as they become available, so resources published in a previous MRB may not yet be available for 2020.
Wyoming (WY)

This report presents Wyoming\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Wyoming for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.
Behavioral Health Barometer: New Jersey, 2014

This is a behavioral health report for the state of New Jersey. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment, and medicare enrollees for the years 2009 to 2013.
Paroxetine

Paroxetine is a prescription medication that acts as a serotonin reuptake inhibitor, commonly used to treat depression, anxiety disorders, OCD, and PTSD. This generic version, approved under ANDA212645, is available as extended-release oral tablets in strengths of 12.5 mg, 25 mg, and 37.5 mg, manufactured by Cadila Pharmaceuticals Limited. This information was generated using AI and is provided for informational and research purposes only.
Positive Parenting Is Key to Preventing Child Maltreatment

Positive parenting is a crucial part of preventing child maltreatment and child abuse and neglect. Two successful strategies, the Triple P-Positive Parenting Program system of interventions and the Circle of Parents Mutual Self-Help Parent Support Group, are described in this webinar: their structures, guiding principles, implementations, funding, training, evaluations, findings, and other aspects.

Presenters: Cheri Shapiro, Ph.D., Research Assistant Professor and Project Director of Building Connections at the University of South Carolina; Christie Ferris, Director of Prevent Child Abuse Florida at the Ounce of Prevention Fund of Florida in Tallahassee; and Mary Kay Falconer, Ph.D., Senior Evaluator at the Ounce of Prevention Fund in Florida

View Webinar (WMV - 86 MB)

Metadata-only record linking to the original dataset. Open original dataset below.
Compound 527838: Pyroglutamic acid, butyl ester, TFA

Chemical compound data from PubChem database. IUPAC Name: butyl 5-oxo-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxylate. Molecular Formula: C11H14F3NO4. Molecular Weight: 281.23. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Child Neglect: Cross Sector Service Paths and Outcomes (1993-2001)

"Child Neglect: Cross Sector Service Paths & Outcomes" was the first phase of a project that is part of a competitive renewal (scheduled to end in 2008). Using administrative data drawn from education, health, juvenile corrections and social service agencies, this study compared cross sector service paths and outcomes of  children in families receiving AFDC and reported to child welfare agencies (1993-1994) compared to a group of children matched by birth year and county of residence in families receiving AFDC, but not reported to child welfare agencies.  Children were born 1982 through 1994 and were all under the age of 12 at the study onset. The total number of children  in the sample is 10,187.  Of the total sample, 5,087 of the children were in the Maltreatment/AFDC group and 5,100 children were in the AFDC Only group. The first phase study AIMS compared maltreated to non-maltreated children according to:  (1) Cross-sector service use (sequence, frequency, co-occurrence & duration); (2) The relationship of service patterns to child and adolescent outcomes (e.g. mortality, foster care entry, entry into Special Education, etc.); (3) The association between certain caretaker level  outcomes (e.g., permanent exit from AFDC) and child and adolescent outcomes. The AIMS were also examined according to type of maltreatment within the maltreated sample group. Key findings indicate that a report of maltreatment does contribute to the risk of special education entry, death, and entry into juvenile corrections above and beyond poverty.  Overall, low-income children who also had maltreatment reports had higher rates of service use and negative outcomes across systems.  The children in the maltreated group also entered more service systems on average than the low-income only group. A caretaker's permanent exit from a first spell on AFDC was associated with lower risk of certain negative outcomes like juvenile court petitions.  This relationship was stronger for the low-income only group. In general, first reports of neglect, physical abuse or mixed type maltreatment were equally likely to result in later poor outcomes. However, children reported for neglect and mixed type(majority includes neglect) maltreatment were more likely to have recurrent reports of maltreatment and recurrent reports were associated with more negative outcomes.

Investigators: Jonson-Reid, M., & Drake, B.
The F-box protein SKP2 mediates androgen control of p27 stability in LNCaP human prostate cancer cells

Background
          The cyclin-dependent kinase inhibitor p27 is a putative tumor suppressor that is downregulated in the majority of human prostate cancers. The mechanism of p27 down-regulation in prostate cancers in unknown, but presumably involves increased proteolysis mediated by the SCFSKP2 ubiquitin ligase complex. Here we used the human prostate cancer cell line LNCaP, which undergoes G1 cell cycle arrest in response to androgen, to examine the role of the SKP2 F-box protein in p27 regulation in prostate cancer.
        
        
          Results
          We show that androgen-induced G1 cell cycle arrest of LNCaP cells coincides with inhibition of cyclin-dependent kinase 2 activity and p27 accumulation caused by reduced p27 ubiquitylation activity. At the same time, androgen decreased expression of SKP2, but did not affect other components of SCFSKP2. Adenovirus-mediated overexpression of SKP2 led to ectopic down-regulation of p27 in asynchronous cells. Furthermore, SKP2 overexpression was sufficient to overcome p27 accumulation in androgen arrested cells by stimulating cellular p27 ubiquitylation activity. This resulted in transient activation of CDK2 activity, but was insufficient to override the androgen-induced G1 block.
        
        
          Conclusions
          Our studies suggest that SKP2 is a major determinant of p27 levels in human prostate cancer cells. Based on our in vitro studies, we suggest that overexpression of SKP2 may be one of the mechanisms that allow prostate cancer cells to escape growth control mediated by p27. Consequently, the SKP2 pathway may be a suitable target for novel prostate cancer therapies.
Compound 529166: 1-Octadecanamine, bis-TMS

Chemical compound data from PubChem database. IUPAC Name: N,N-bis(trimethylsilyl)octadecan-1-amine. Molecular Formula: C24H55NSi2. Molecular Weight: 413.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
NNDSS - Table 1F. Brucellosis to Candida auris, clinical

NNDSS - Table 1F. Brucellosis to Candida auris, clinical - 2021. In this Table, provisional cases* of notifiable diseases are displayed for United States, U.S. territories, and Non-U.S. residents.

Notice: Due to data processing issues at CDC, data for the following jurisdictions may be incomplete for week 7: Alaska, Arizona, California, Connecticut, Delaware, Florida, Hawaii, Louisiana, Maryland, Michigan, Missouri, North Dakota, New Hampshire, New York City, Oregon, Pennsylvania, and Rhode Island.

Note: 
This table contains provisional cases of national notifiable diseases from the National Notifiable Diseases Surveillance System (NNDSS). NNDSS data from the 50 states, New York City, the District of Columbia and the U.S. territories are collated and published weekly on the NNDSS Data and Statistics web page (https://wwwn.cdc.gov/nndss/data-and-statistics.html). Cases reported by state health departments to CDC for weekly publication are provisional because of the time needed to complete case follow-up. Therefore, numbers presented in later weeks may reflect changes made to these counts as additional information becomes available. The national surveillance case definitions used to define a case are available on the NNDSS web site at https://wwwn.cdc.gov/nndss/. Information about the weekly provisional data and guides to interpreting data are available at: https://wwwn.cdc.gov/nndss/infectious-tables.html. 

Footnotes:
U: Unavailable — The reporting jurisdiction was unable to send the data to CDC or CDC was unable to process the data.
-: No reported cases — The reporting jurisdiction did not submit any cases to CDC.
N: Not reportable — The disease or condition was not reportable by law, statute, or regulation in the reporting jurisdiction.
NN: Not nationally notifiable — This condition was not designated as being nationally notifiable.
NP: Nationally notifiable but not published.
NC: Not calculated — There is insufficient data available to support the calculation of this statistic.
Cum: Cumulative year-to-date counts.
Max: Maximum — Maximum case count during the previous 52 weeks.
* Case counts for reporting years 2020 and 2021 are provisional and subject to change. Cases are assigned to the reporting jurisdiction submitting the case to NNDSS, if the case's country of usual residence is the U.S., a U.S. territory, unknown, or null (i.e. country not reported); otherwise, the case is assigned to the 'Non-U.S. Residents' category. Country of usual residence is currently not reported by all jurisdictions or for all conditions. For further information on interpretation of these data, see https://wwwn.cdc.gov/nndss/document/Users_guide_WONDER_tables_cleared_final.pdf.
†Previous 52 week maximum and cumulative YTD are determined from periods of time when the condition was reportable in the jurisdiction (i.e., may be less than 52 weeks of data or incomplete YTD data). 
§ Reporting jurisdictions were informed CDC could receive data for this condition in August 2019. Please note there will be a delay in reporting of case notifications for this condition to CDC.
Compound 528194: 1,2-Propanediol, 3-(4-chlorophenyloxy), DTBS

Chemical compound data from PubChem database. IUPAC Name: 2,2-ditert-butyl-4-(4-chlorophenoxy)-1,3,2-dioxasilolane. Molecular Formula: C16H25ClO3Si. Molecular Weight: 328.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528132: 3-Methyl-5-(2-methylbutyl)-2-(phenylthio)pyrazine

Chemical compound data from PubChem database. IUPAC Name: 3-methyl-5-(2-methylbutyl)-2-phenylsulfanylpyrazine. Molecular Formula: C16H20N2S. Molecular Weight: 272.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Glycerol restores heat-induced p53-dependent apoptosis of human glioblastoma cells bearing mutant p53

Background
          We have previously reported that glycerol acts as a chemical chaperone to restore the expression of WAF1 in some human cancer cell lines bearing mutant p53. Since the expression of WAF1 is up-regulated by activated wildtype p53, glycerol appears to restore wtp53 function. The aim of the present study is to examine the restoration of heat-induced p53-dependent apoptosis by glycerol in human glioblastoma cells (A-172) transfected with a vector carrying a mutant p53 gene (A-172/mp53 cells) or neo control vector (A-172/neo cells).
        
        
          Results
          A-172/mp53 cells showed heat resistance compared with A-172/neo cells but A-172/mp53 cells in turn became heat sensitive when pre-treated with glycerol before heat treatment. The accumulation of Bax in the A-172/mp53 cells was induced by heating with glycerol pre-treatment, but not without it, whereas the accumulation in the A-172/neo cells was induced in both cases. Furthermore, mp53 extracted from heated cells came to bind to the sequence specific region after heating combined with glycerol pre-treatment. The phosphorylation of mp53 at serine15 was suppressed by an inhibitor of the phosphatidylinositol 3-kinase (PI3-K) family.
        
        
          Conclusion
          These results suggest that glycerol is effective in inducing conformational change of phosphorylated p53 and restoring mp53 to wtp53 function, leading to enhanced heat sensitivity through the induction of apoptosis. This novel tool for enhancement of heat sensitivity in cancer cells bearing mp53 may be applicable for p53-targeted hyperthermia, because mutation or inactivation of p53 is observed in approximately 50% of human cancers.
NCHS Survey Data Linked to Centers for Medicare & Medicaid Services (CMS) MAX Data

NCHS has linked various surveys with the Medicaid Analytic eXtract (MAX) files collected from the Centers for Medicare & Medicaid Services (CMS). Linkage of the NCHS survey participants with the CMS Medicaid MAX data provides the opportunity to study changes in health status, health care utilization and expenditures in low-income families with children and the elderly U.S. populations.
Patent AT-E400137-T1: [Translated] MOBILE DEVICE WITH A VIBRATING COMPONENT WITH LIGHT EFFECTS

Mobile phones use light signaling or vibrational effects to silently indicate to a user that e.g. a telephone call is incoming. The present invention provides a method, a component for generating vibrational effects combined with light effects and a mobile device implementing this component. The generation of the light effects is obtained from at least one light emitter ( 200, 201 ) having at least one light path ( 300 ), wherein said at least one light emitter ( 200, 201 ) is disposed relative to said mass ( 100 ) such that said mass ( 100 ) periodically blocks said light path ( 300 ) while moving, for generating light effects.