AndreaBozzo/ceres-open-data-index huggingface dataset:
Generation of choline for acetylcholine synthesis by phospholipase D isoforms

Dedication
           This article is dedicated to the memory of Sue Kim Hanson, a graduate student in the department of Pathology and Laboratory Medicine at Boston University School of Medicine, who perished in the terrorist attacks of September 11, 2001.
        
        
          Abstract
          
            Background
            In cholinergic neurons, the hydrolysis of phosphatidylcholine (PC) by a phospholipase D (PLD)-type enzyme generates some of the precursor choline used for the synthesis of the neurotransmitter acetylcholine (ACh). We sought to determine the molecular identity of the relevant PLD using murine basal forebrain cholinergic SN56 cells in which the expression and activity of the two PLD isoforms, PLD1 and PLD2, were experimentally modified. ACh levels were examined in cells incubated in a choline-free medium, to ensure that their ACh was synthesized entirely from intracellular choline.
          
          
            Results
            PLD2, but not PLD1, mRNA and protein were detected in these cells and endogenous PLD activity and ACh synthesis were stimulated by phorbol 12-myristate 13-acetate (PMA). Introduction of a PLD2 antisense oligonucleotide into the cells reduced PLD2 mRNA and protein expression by approximately 30%. The PLD2 antisense oligomer similarly reduced basal- and PMA-stimulated PLD activity and ACh levels. Overexpression of mouse PLD2 by transient transfection increased basal- (by 74%) and PMA-stimulated (by 3.2-fold) PLD activity. Moreover, PLD2 transfection increased ACh levels by 26% in the absence of PMA and by 2.1-fold in the presence of PMA. Overexpression of human PLD1 by transient transfection increased PLD activity by 4.6-fold and ACh synthesis by 2.3-fold in the presence of PMA as compared to controls.
          
          
            Conclusions
            These data identify PLD2 as the endogenous enzyme that hydrolyzes PC to generate choline for ACh synthesis in cholinergic cells, and indicate that in a model system choline generated by PLD1 may also be used for this purpose.
Design of a trial evaluating myocardial cell protection with cariporide, an inhibitor of the transmembrane sodium-hydrogen exchanger: the Guard During Ischemia Against Necrosis (GUARDIAN) trial

Inhibition of the sodium-hydrogen exchanger (NHE) is a powerful experimental tool to inhibit sodium and calcium accumulation within the ischemic myocyte and halt progression of cell ischemia to cell necrosis. This paper describes the protocol and rationale of a first large-scale clinical trial designed to evaluate the safety and efficacy of cariporide, a novel specific and potent inhibitor of the exchanger.
Compound 526248: 1,2,6,8-Tetrabromo-dibenzofuran

Chemical compound data from PubChem database. IUPAC Name: 1,2,6,8-tetrabromodibenzofuran. Molecular Formula: C12H4Br4O. Molecular Weight: 483.77. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Colorado 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.
Compound 528949: Phenol, 2-(1-ethylhexyl)-6-nitro

Chemical compound data from PubChem database. IUPAC Name: 2-nitro-6-octan-3-ylphenol. Molecular Formula: C14H21NO3. Molecular Weight: 251.32. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Table 24. Serious Mental Illness in the Past Year among Persons Aged 18 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2008, 2009, and 2010 NSDUHs

This table presents the 2008 to 2010 National Survey on Drug Use and Health (NSDUH) estimates of past year serious mental illness among those aged 18 or older by State and substate regions.
Five Steps for Stronger Child Welfare Workforce

This Child Welfare Information Gateway Podcast is available on Apple Podcasts
  
  

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Metadata-only record linking to the original dataset. Open original dataset below.
Compound 530401: 2-Ethyldihydro-3(2H)-thiophenone

Chemical compound data from PubChem database. IUPAC Name: 2-ethylthiolan-3-one. Molecular Formula: C6H10OS. Molecular Weight: 130.21. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 529760: 1,4-Dithiacyclohept-5-ene

Chemical compound data from PubChem database. IUPAC Name: 3,5-dihydro-2H-1,4-dithiepine. Molecular Formula: C5H8S2. Molecular Weight: 132.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 525313: 2-Propen-1-amine, 3-chloro-N-ethyl-2-methyl-

Chemical compound data from PubChem database. IUPAC Name: 3-chloro-N-ethyl-2-methylprop-2-en-1-amine. Molecular Formula: C6H12ClN. Molecular Weight: 133.62. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Publications Using SAMHSA DataAdult Mental Health Tables (Prevalence Estimates) - 1.1 to 1.64

These are the detailed tables pertaining to adult mental health from the 2010 National Survey on Drug Use and Health (NSDUH). These detailed tables present totals and prevalence estimates of past year any mental illness (AMI), serious mental illness (SMI), suicidal thoughts and behavior, major depressive episode (MDE), treatment for depression (among adults with MDE), mental health service utilization, and measuers related to the co-occurrence of mental disorders with substance use or with substance use disorders. Results are provided for age group, gender, race/ethnicity, education level, employment status, poverty level, geographic area, insurance status. Comparisons are made between 2010 and 2002 to 2009.
Promoting Social and Emotional Well-being: Uses and Limitations of Screening and Assessment Instruments

Presented by two national experts, this two-part webinar addresses the importance of screening and assessment in efforts to improve the well-being of children and youth. Part 1 includes an overview of evidence-informed trauma and behavioral health screening and assessment tools, including their uses and intended populations. Informed by the National Study of Child and Adolescent Well-being (NSCAW), Part 2 focuses on measuring well-being in the context of child welfare evaluations. The presenter discusses the relevance of select assessment instruments to evaluation efforts, as well as critical issues to consider when attempting to measure changes in the well-being of children and youth over time.

View Audio (MP3 - 31,843 KB)
View Transcript (PDF) (PDF - 104.11 KB)

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NHRIC (National Health Related Items Code)

The National Health Related Items Code (NHRIC) is a system for identification and numbering of marketed device packages that is compatible with other numbering systems such as the National Drug Code (NDC) or Universal Product Code (UPC). Those manufacturers who desire to use the NHRIC number for unique product identification may apply to FDA for a labeler code. This database contains NHRIC data retrieved from records that date back 20 years.
The importance of balanced pro-inflammatory and anti-inflammatory mechanisms in diffuse lung disease

The lung responds to a variety of insults in a remarkably consistent fashion but with inconsistent outcomes that vary from complete resolution and return to normal to the destruction of normal architecture and progressive fibrosis. Increasing evidence indicates that diffuse lung disease results from an imbalance between the pro-inflammatory and anti-inflammatory mechanisms, with a persistent imbalance that favors pro-inflammatory mediators dictating the development of chronic diffuse lung disease. This review focuses on the mediators that influence this imbalance.
Patent AT-E401771-T1: [Translated] METHOD FOR SWITCHING ON AT LEAST ONE OPTIONAL SETTING VALUE IN A PLACING MACHINE, A PLACING MACHINE AND AN ELECTRONIC KEY

A method and a component placement device are proposed for adjusting at least one optional setting of a process characteristic of the component placement device, which component placement device has at least one standard setting. The optional setting can be activated by means of an electronic key to be supplied to the component placement device. The optional setting is temporarily activated by feeding the electronic key to the component placement device, whilst the standard setting is reactivated at least after the expiry of a predetermined period of operation of the electronic key.
New York State Statewide COVID-19 Vaccination Data by County (Archived, Initial)

<b>Note:</b> As of November 10, 2023, this dataset has been archived. For the current version of this data, please visit: https://health.data.ny.gov/d/gikn-znjh

This dataset reports daily on the number of people vaccinated by New York providers with at least one dose and with a complete COVID-19 vaccination series overall since December 14, 2020. New York providers include hospitals, mass vaccination sites operated by the State or local governments, pharmacies, and other providers registered with the State to serve as points of distribution.

This dataset is created by the New York State Department of Health from data reported to the New York State Immunization Information System (NYSIIS) and the New York City Citywide Immunization Registry (NYC CIR). County-level vaccination data is based on data reported to NYSIIS and NYC CIR by the providers administering vaccines.  Residency is self-reported by the individual being vaccinated. This data does not include vaccine administered through Federal entities or performed outside of New York State to New York residents. NYSIIS and CIR data is used for county-level statistics. New York State Department of Health requires all New York State vaccination providers to report all COVID-19 vaccination administration data to NYSIIS and NYC CIR within 24 hours of administration.
Treatment Episode Data Set (TEDS): 2018 Admissions To and Discharges From Publicly-Funded Substance Use Treatment

This report presents national- and state-level data from the Treatment Episode Data Set (TEDS) for admissions and discharges occurring in 2018, and trend data from 2008 to 2018. It summarizes demographic information and the characteristics and outcomes of treatment for alcohol and/or drug use among clients aged 12 years and older in facilities that report to individual state administrative data systems. Data include records for treatment admissions and discharges that were received and processed through November 18, 2019.TEDS records do not represent individuals; rather, each record represents a treatment episode. Thus, an individual admitted to treatment twice within a calendar year is counted as two admissions. Similarly, discharges during the year, regardless of when the admission occurred, are counted.TEDS does not include all substance use treatments. It includes treatment admissions and discharges at facilities that are licensed or certified by a state substance abuse agency to provide care for people with a substance use disorder (or facilities that are administratively tracked for other reasons). In general, facilities reporting TEDS data are those that receive state alcohol and/or drug agency funds (including federal block grant funds) for the provision of alcohol and/or drug treatment services. Additional information on the history and methodology of TEDS and this report, as well as important issues related to state data collection systems, are available in Appendix A.
Tumor necrosis factor and lymphotoxin-alpha genetic polymorphisms and risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia: a case-control study of patients treated with BFM therapy

Background
          Circulating levels of tumor necrosis factor (TNF) and lymphotoxin-α (LT-α) have been associated with outcome in solid and hematologic malignancies. Within the TNF gene and the LT-α gene, polymorphisms have been identified at nucleotide positions -308 and +252, respectively. The variant alleles for TNF are designated TNF1 and TNF2, the ones for LT-α LT-α (10.5 kb) and LT-α (5.5 kb). Of interest, TNF2 and LT-α (5.5 kb) were shown to be associated with higher TNF and LT-α plasma levels than their counterparts. In the present study, we investigated the associations of the above mentioned polymorphisms with risk of relapse in childhood acute lymphoblastic leukemia (ALL) treated according to Berlin-Frankfurt-Münster (BFM) protocols.
        
        
          Methods
          Matched case-control study of 64 relapsed and 64 successfully treated non-relapsed childhood B-cell precursor ALL patients of standard and intermediate risk for treatment failure.
        
        
          Results
          The odds ratio (OR) for the combined category of TNF1/TNF2 and TNF2/TNF2 genotypes in comparison to the TNF1/TNF1 genotype was 1.17 (95 % confidence interval (CI) = 0.53 - 2.56, P = 0.697). The ORs for the LT-α (10.5 kb/5.5 kb) and the LT-α (5.5 kb/5.5 kb) genotypes with reference to the LT-α (10.5 kb/10.5 kb) genotype were 2.17 (95 % CI = 0.84 - 5.58, P = 0.107) and 0.5 (95 % CI = 0.09 - 2.66, P = 0.418), respectively.
        
        
          Conclusions
          Our results do not suggest a major role of the investigated genetic polymorphisms with regard to risk of relapse in standard- and intermediate-risk childhood B-cell precursor ALL treated according to BFM protocols.
Patent AT-E401397-T1: [Translated] DIRECTED EVOLUTION OF BIOMOLECULES USING MICROSTRUCTURES

Selection (M1) of genotype variants from libraries in a micro-structure comprising feeding a test fluid (102) containing a genotype library in an expressible form and with suitable expression aids into a micro-structure together with a barrier fluid (101) to form separate compartments (109,111) in the test fluid, is new. An assay fluid (103) can be added to the test fluid compartments in (M1). The compartments are carried through the micro-structure to give an expression of the genotype in the phenotype in the compartments, for the phenotypes to be detected. The compartments are selected according to their detected phenotypes.
Child and Family Services Review Update Volume 18, Issue 1, December 2023

This issue of Child and Family Services Reviews Update contains the following sections: Year 2 of the Round 4 CFSRs Approaches, Training Consultations Available to States for 2024, Capacity Building Centers Provide a Variety of Resources, Program Improvement Planning Gets Underway, and Spanish Translations Added to Portal.

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Compound 525248: N''-(4-fluoro-phenyl)-N,N,N',N'-tetramethyl-guanidine

Chemical compound data from PubChem database. IUPAC Name: 2-(4-fluorophenyl)-1,1,3,3-tetramethylguanidine. Molecular Formula: C11H16FN3. Molecular Weight: 209.26. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 526356: 3,7-Dibromodibenzo[b,d]furan

Chemical compound data from PubChem database. IUPAC Name: 3,7-dibromodibenzofuran. Molecular Formula: C12H6Br2O. Molecular Weight: 325.98. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528728: 5-Hydroxytryptamine, DTFMB-TMS

Chemical compound data from PubChem database. IUPAC Name: 3,5-bis(trifluoromethyl)-N-[2-(5-trimethylsilyloxy-1H-indol-3-yl)ethyl]benzamide. Molecular Formula: C22H22F6N2O2Si. Molecular Weight: 488.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 527383: 22,26-Dimethyl-dotriacontyl cyanide

Chemical compound data from PubChem database. IUPAC Name: 23,27-dimethyltritriacontanenitrile. Molecular Formula: C35H69N. Molecular Weight: 503.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E400444-T1: [Translated] NOTEBOOK

Chemical patent from PubChem database. Patent Number: AT-E400444-T1. Title: Method of Treatment Using Chemical Compounds. Filing Date: 2006-11-26. Inventors: Rodriguez, Juan, White, Jennifer. Abstract: Methods for treating diseases using specific chemical compounds are provided, including dosing regimens and combination therapies for enhanced therape... IPC Classifications: C07C, C07B, A61K. This patent covers 34 claims related to 8 chemical compounds. Useful for intellectual property research, prior art searches, and chemical innovation tracking.
2013 CMHS Uniform Reporting System (URS) Tables for Federated States of Micronesia

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for Federated States of Micronesia for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
Program Instruction (PI-03-05)

This Program Instruction (PI) provides instruction on the June 30, 2003 submission of the Annual Progress and Services Report required under title IV-B of the Social Security Act (the Act), the Child Abuse Prevention and Treatment Act (CAPTA), and the Chafee Foster Care Independence Program (CFCIP); and the CFS-101, Annual Budget Request and Annual Summary of Child and Family Services.

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Compound 525891: N,N-Dimethyl-N'-(4-methylphenyl)-pivalamidine

Chemical compound data from PubChem database. IUPAC Name: N,N,2,2-tetramethyl-N'-(4-methylphenyl)propanimidamide. Molecular Formula: C14H22N2. Molecular Weight: 218.34. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E399980-T1: [Translated] POSITION DETECTION DEVICE

A position detecting means comprising a sensor arrangement ( 14 ) for producing at least one sensor signal in a fashion dependent on a body ( 11 ) moving past said means, the sensor signal or signals continuously changing on such movement past. The at least one sensor signal is compared with at least one reference value in a comparator arrangement ( 20 ), control means being provided for electronic setting of the sensor arrangement ( 14 ) by changing the reference value and the output signal of the comparator arrangement ( 20 ) forms the position signal (P) for detection of a relative position of the body ( 11 ) and the sensor arrangement ( 14 ). Accordingly it is possible for the arrangement ( 14 ) to be mechanically set in a relatively rough manner and fine adjustment may be performed by changing the reference value electronically.
Compound 527222: 1,4a-Dimethyl-7-propan-2-yl-3,4,5,6-tetrahydronaphthalen-2-one

Chemical compound data from PubChem database. IUPAC Name: 1,4a-dimethyl-7-propan-2-yl-3,4,5,6-tetrahydronaphthalen-2-one. Molecular Formula: C15H22O. Molecular Weight: 218.33. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528346: Phenol, 2,4-dichloro, TMS

Chemical compound data from PubChem database. IUPAC Name: (2,4-dichlorophenoxy)-trimethylsilane. Molecular Formula: C9H12Cl2OSi. Molecular Weight: 235.18. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E400438-T1: [Translated] INK CARTRIDGE

The ink cartridge (10) has an ink chamber and an elastic insert in a channel opening into the chamber and clamped against a stop in the axial direction so that the end of the insert not in contact with the stop is held in contact with a porous ink reservoir , whereby the porous insert is deformed by the clamping force so that its mean pore size is less than/equal to that of the ink reservoir.
Patent AT-E401678-T1: [Translated] COAXIAL CONNECTOR WITH A REMOVABLE LOCKING RING

A connector is provided for attachment to a coaxial cable. The connector includes, in one embodiment, a connector body and a locking sleeve. The locking sleeve is configured to be moved between an attached and a detached state. In each such state, the locking sleeve is configured to receive the end of the cable. In one position, the locking sleeve is configured to lock the end of the cable to the connector body.
Patent AT-E399929-T1: [Translated] HOUSING ARRANGEMENT FOR THE TURBOCHARGER OF AN INTERNAL COMBUSTION ENGINE

The housing arrangement for the turbocharger of an internal combustion engine has a rotor casing (4) with an inlet duct (1), an exhaust gas overflow section (9) connected to the rotor casing and connected to an exhaust flange (11), and an outer casing (12) enclosing the overflow section, rotor casing and inlet duct. The overflow section is connected to the rotor casing to move relative to it. The rotor casing has an axially orientated pipe-form outlet connector (8) over which fits the cylindrical end (13) of the overflow section with relative movement capability.
Compound 526790: Methyl 3-[tert-butyl(dimethyl)silyl]oxyhexadecanoate

Chemical compound data from PubChem database. IUPAC Name: methyl 3-[tert-butyl(dimethyl)silyl]oxyhexadecanoate. Molecular Formula: C23H48O3Si. Molecular Weight: 400.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Texas 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.