AndreaBozzo/ceres-open-data-index huggingface dataset:
Health Care Coverage Status (BRFSS): Beginning 2011

Behavioral Risk Factor Surveillance System (BRFSS) sample data were used to generate annual percentages of non-institutionalized adult (18+) NYS residents with/without health insurance coverage. Health care coverage percentages are provided for 2011 forward, and are available for a range of demographic and geographic categories (New York City/Rest of State; DSRIP Region; Sex; Race/Ethnicity; Age; Education; Income; Limitation Status (through 2017); Disability Status (beginning in 2016); Employment Status; and Mental Health Status). 
BRFSS is a random digit dialing (RDD) phone survey of the health status and health behaviors of adult NYS residents. The sample covers between 6,800 and 36,000 completed interviews annually through this timeframe.
Patent AT-E399678-T1: [Translated] EXPANDABLE AND CONTRACTABLE WORK SPACE ON A WHEEL-SUPPORTED CHASSIS

At least one of the partition walls (4-10) inside the office has a section (41, 51, 61, 91, 101) which is pivotally connected to the office base structure (1) or one of the boxes (2, 3) so that it can be pivoted about a vertical axis close to the central length axis for the base structure or about a vertical axis close to one of the box length side walls (21, 31) so that it extends parallel to the box latter, allowing the box to be folded away into its retracted position. An orthogonal parallelepiped base structure is mounted on a chassis with wheels and has an opening in each of its two opposing side walls for locating an orthogonal parallelepiped box which is open on the side facing the base structure. Each box can be moved in a linear manner between a retracted position in which the box side wall is next to the base structure side wall and an extended position in which the box side wall is located beyond the base structure side wall. The partition walls extend in the office cross- direction.
Compound 526848: Acetic acid 5-acetoxy-4-methoxy-tetrahydro-pyran-3-yl ester

Chemical compound data from PubChem database. IUPAC Name: (5-acetyloxy-4-methoxyoxan-3-yl) acetate. Molecular Formula: C10H16O6. Molecular Weight: 232.23. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Appendix 3 -Disaster Relief Flexibilities to Reduce Burden for Financial Assistance

The Office of Management and Budget (OMB) has issued administrative relief guidance for recipients and applicants of Federal financial assistance. Inquiries may be directed to childrensbureauCOVIDflexibilities@acf.hhs.gov and your Project Officer and Grants Management Specialist.

Browse All COVID-19 Resources

Metadata-only record linking to the original dataset. Open original dataset below.
SHIP Increase Physical Activity 2011-2019

Physical Activity - This indicator shows the number of persons who reported at least 150 minutes of moderate physical activity or at least 75 minutes of vigorous physical activity per week. Physical activity is important to prevent heart disease and stroke, two of the important causes of death in United States. In order to improve overall cardiovascular health, The American Heart Association suggests at least 150 minutes per week of moderate exercise or 75 minutes per week of vigorous exercise. <a href ="https://health.maryland.gov/pophealth/Documents/SHIP/SHIP%20Lite%20Data%20Details/Increase%20in%20Physical%20Activity.pdf" > Link to Data Details </a>
Compound 528998: Octacosane, 1,2-bis(methylthio)

Chemical compound data from PubChem database. IUPAC Name: 1,2-bis(methylsulfanyl)octacosane. Molecular Formula: C30H62S2. Molecular Weight: 486.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Molecular action of methotrexate in inflammatory diseases

Despite the recent introduction of biological response modifiers and potent new small-molecule antirheumatic drugs, the efficacy of methotrexate is nearly unsurpassed in the treatment of inflammatory arthritis. Although methotrexate was first introduced as an antiproliferative agent that inhibits the synthesis of purines and pyrimidines for the therapy of malignancies, it is now clear that many of the anti-inflammatory effects of methotrexate are mediated by adenosine. This nucleoside, acting at one or more of its receptors, is a potent endogenous anti-inflammatory mediator. In confirmation of this mechanism of action, recent studies in both animals and patients suggest that adenosine-receptor antagonists, among which is caffeine, reverse or prevent the anti-inflammatory effects of methotrexate.
2021-2022 NSDUH State Estimates of Substance Use and Mental Disorders

Find state-level estimates for 35 measures of substance use and mental health from the 2021-2022 National Surveys on Drug Use and Health (NSDUH). These estimates are based on small area estimation (SAE) methods in which state-level NSDUH data are combined with other data from smaller geographies. The combined data are used to create modeled state estimates of the civilian, noninstitutionalized population ages 12 and older.Along with the estimates, the collection includes an overview of the estimation methodology, a review of other state-level substance use and mental health data sources, and a document describing the groups used for mapping. The data are available in several forms: images of national maps and tables both overall and by age. There are also tables of p-values indicating whether differences between particular geographies are statistically significant.The indicators are presented in the following 37 tables:Drug use and Perceived RiskIllicit Drug Use in the Past MonthMarijuana Use in the Past YearMarijuana Use in the Past MonthPerceptions of Great Risk from Smoking Marijuana Once a MonthFirst Use of Marijuana in the Past Year (among those at risk for initiation)Illicit Drug Use Other than Marijuana in the Past MonthCocaine Use in the Past YearPerceptions of Great Risk from using Cocaine Once a MonthHeroin Use in the Past YearPerceptions of Great Risk from Trying Heroin Once or TwiceHallucinogen Use in the Past YearMethamphetamine Use in the Past YearPrescription Pain Reliever Misuse in the Past YearOpioid Misuse in the Past YearAlcoholAlcohol Use in the Past MonthBinge Alcohol Use in the Past MonthPerceptions of Great Risk from Having Five or More Drinks of an Alcoholic Beverage Once or Twice a WeekAlcohol Use, Binge Alcohol Use in the Past Month, and Perceptions of Great Risk from Having Five or More Drinks of an Alcoholic Beverage Once or Twice a Week (among people aged 12 to 20)TobaccoTobacco Product Use in the Past MonthCigarette Use in the Past MonthPerceptions of Great Risk from Smoking One or More Packs of Cigarettes per DaySubstance Use DisordersSubstance Use Disorder in the Past YearAlcohol Use Disorder in the Past YearAlcohol Use Disorder in the Past Year (among people aged 12 to 20)Drug Use Disorder in the Past YearPain Reliever Use Disorder in the Past YearOpioid Use Disorder in the Past YearSubstance Use TreatmentReceived Substance Use Treatment in the Past YearClassified as Needing Substance Use Treatment in the Past YearDid Not Receive Substance Use Treatment in the Past Year among those Classified as Needing Substance Use TreatmentMental IllnessAny Mental Illness in the Past YearSerious Mental Illness in the Past YearReceived Mental Health Treatment in the Past YearMajor Depressive Episode in the Past YearSuicidalityHad Serious Thoughts of Suicide in the Past YearMade Any Suicide Plans in the Past YearAttempted Suicide in the Past Year
Is endosonography an effective method for detection and local staging of the ampullary carcinoma? A prospective study

Background
          The relatively rare carcinoma of the ampulla of Vater is a neoplasia with a good prognosis compared to pancreatic cancer. Preoperative staging is important in planning the most suitable surgical intervention.
        
        
          Aim
          To prospectively evaluate the diagnostic accuracy of Endoscopic Ultrasonography (EUS) in comparison with conventional US and CT scan, in staging of patients with ampullary carcinoma.
        
        
          Patients and Methods
          20 patients (7 women and 13 men) with histologically proven carcinoma of the ampulla of Vater were assessed by EUS, CT scan and US. Results were compared to surgical findings.
        
        
          Results
          Endoscopic biopsies were diagnostic in 76% of the patients. Detection of ampullary cancer with US and CT scan was 15% and 20% respectively. Only indirect signs of the disease were identified in the majority of cases using these methods. Overall accuracy of EUS in detection of ampullary tumours was 100%. The EUS was significantly (p < 0.001) superior than US and CT scan in ampullary carcinoma detection. Tumour size, tumour extension and the existence of metastatic lymph nodes were also identified and EUS proved to be very useful for the preoperative classification both for the T and the N components of the TNM staging of this neoplasia. The diagnostic accuracy for tumour extension (T) was 82% and for detection of metastatic lymph nodes (N) was 71%.
        
        
          Conclusion
          EUS is more accurate in detecting ampullary cancer than US and CT scan. Tumor extension and locally metastatic lymph nodes are more accurately assessed by means of EUS than with other imaging methods.
Approaches to enhancing the retroviral transduction of human synoviocytes

This report concerns a clinical trial for rheumatoid arthritis (RA), approved by the US National Institutes of Health and the Food and Drug Administration. An amphotropic retrovirus (MFG-IRAP) was used ex vivo to transfer a cDNA encoding human interleukin-1 receptor antagonist (IL-1Ra) to synovium. The protocol required the transduced cells to secrete at least 30 ng IL-1Ra/106 cells per 48 h before reimplantation. Here we have evaluated various protocols for their efficiency in transducing cultures of human rheumatoid synoviocytes. The most reliably efficient methods used high titer retrovirus (approximately 108 infectious particles/ml). Transduction efficiency was increased further by exposing the cells to virus under flow-through conditions. The use of dioctadecylamidoglycylspermine (DOGS) as a polycation instead of Polybrene (hexadimethrine bromide) provided an additional small increment in efficiency. Under normal conditions of static transduction, standard titer, clinical grade retrovirus (approximately 5 × 105 infectious particles/ml) failed to achieve the expression levels required by the clinical trial. However, the shortfall could be remedied by increasing the time of transduction under static conditions, transducing under flow-through conditions, or transducing during centrifugation.
2011 CMHS Uniform Reporting System (URS) Output Tables for Pennsylvania

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2011. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
Alaska: 2011-2012 NSDUH

This report presents Alaska\'s estimates for 25 measures of substance use and mental health based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.
Paliperidone

Paliperidone is an atypical antipsychotic medication used to treat schizophrenia and schizoaffective disorder. It comes as extended-release oral tablets in strengths of 1.5 mg, 3 mg, 6 mg, and 9 mg, manufactured by Amneal Pharmaceuticals LLC (ANDA204707). This information was generated using AI and is provided for informational and research purposes only.
Oral sildenafil (Viagra™) in male erectile dysfunction: use, efficacy and safety profile in an unselected cohort presenting to a British district general hospital.

Introduction
          Sildenafil (Viagra®) is one of the drugs used in the first line therapy of male erectile dysfunction (MED). We have recorded outcomes, adverse events and acceptability of Sildenafil (Viagra) therapy in an unselected group of men presenting with ED to a British district general hospital.
        
        
          Methods
          In this prospective observational study, 147 men with ED were seen since Oct 1999. Study patients were reviewed at 4, 12 and 52 weeks. All the patients filled the International Index of Erectile Function (IIEF) questionnaire and were asked about their willingness to pay (WTP) for treatment.
        
        
          Results
          All suitable men accepted Viagra as first line therapy. 91% of our patients found sildenafil treatment successful. 80% of these patients were willing to continue with sildenafil therapy. Side effect profile of sildenafil was different in this study with much higher incidence of headache, dyspepsia, flushing and abnormal vision. 92% of men with ED expect to be treated by the NHS. Of those men eligible for treatment in the NHS, 30% qualify under the clinical categories and 18% under the 'distress' category. Only 55% of those with cardiovascular risk factors qualify for NHS treatment.
        
        
          Conclusions
          Sildenafil is widely accepted as first line therapy among British men with ED and has a success rate of 91%. Nearly half of men with ED qualify for NHS treatment. Nearly half of those with vascular risk factors do not qualify for NHS treatment. Most men with ED could possibly be managed in primary care.
Table 2. Marijuana Use in the Past Year among Persons Aged 12 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2010, 2011, and 2012 NSDUHs

Table 2. Marijuana Use in the Past Year among Persons Aged 12 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2010, 2011, and 2012 NSDUHs
Nifedipine

Nifedipine is a generic prescription medication that belongs to a class of drugs called calcium channel blockers. It comes in extended-release tablets (30mg, 60mg, or 90mg) taken orally to help treat high blood pressure and chest pain (angina) by relaxing blood vessels. Manufactured by Ingenus Pharmaceuticals, LLC, it's approved under ANDA202987. This information was generated using AI and is provided for informational and research purposes only.
Podofilox

Podofilox is a prescription topical gel used to treat genital warts caused by human papillomavirus (HPV). It works by slowing the growth of abnormal skin cells. Apply a small amount to affected areas twice daily for 3 days, then stop for 4 days, repeating as needed. Consult a doctor for proper use. This information was generated using AI and is provided for informational and research purposes only.
Supporting Evidence-Based Home Visitation Programs to Prevent Child Abuse and Neglect Project: Rochester Society for the Prevention and Cruelty to Children

Location:

Monroe County (Rochester)

Home Visiting Program Selected:

Nurse Family Partnership; Parents as Teachers

Home Visiting Target Population:

At-risk, low-income parents who had their first child below age 21

Project Overview:
The Rochester Society for the Prevention of Cruelty to Children will collaborate with seven community partners to examine the benefits of combining multiple evidence-based home visitation and other models to effectively meet the needs of families at the greatest risk, with the goal of reducing child maltreatment and enhancing family functioning. Depending on eligibility, families will receive Nurse Family Partnership or other evidence-base programs, including Parents as Teachers. During intake, families will participate in a comprehensive screening process that identifies whether the family needs more intense mental health therapy. A rigorous evaluation will compare treatment delivery through a multi-tiered evidence-based service delivery model that includes Nurse Family Partnership services. Program participants will first be screened for Nurse Family Partnership eligibility. If ineligible, they will then be randomly assigned to alternative evidence-based home visitation services or to an enhanced treatment as usual group that includes only referrals to community resources. To support their building a sustainable infrastructure, a Steering Committee will explore leveraging of funding streams and develop a model capable of national replication for sustainability.

Metadata-only record linking to the original dataset. Open original dataset below.
National Sexual Violence Resource Center (NSVRC)

<p>The National Sexual Violence Resource Center (NSVRC) is a national information and resource hub relating to all aspects of sexual violence.</p>
<p>NSVRC staff collect and disseminate a wide range of resources on sexual violence including statistics, research, position statements, statutes, training curricula, prevention initiatives and program information. With these resources, NSVRC assists coalitions, advocates and others interested in understanding and eliminating sexual violence. NSVRC has an active and diverse Advisory Council that assists and advises staff and ensures a broad national perspective. NSVRC also enjoys a strong partnership with state, territory and tribal anti-sexual assault coalitions and allied organizations.</p>
<p>NSVRC is funded through a cooperative agreement from the Centers for Disease Control and Prevention (CDC) Division of Violence Prevention.</p>
Fibromyalgia syndrome improved using a mostly raw vegetarian diet: An observational study

Background
          Fibromyalgia engulfs patients in a downward, reinforcing cycle of unrestorative sleep, chronic pain, fatigue, inactivity, and depression. In this study we tested whether a mostly raw vegetarian diet would significantly improve fibromyalgia symptoms.
        
        
          Methods
          Thirty people participated in a dietary intervention using a mostly raw, pure vegetarian diet. The diet consisted of raw fruits, salads, carrot juice, tubers, grain products, nuts, seeds, and a dehydrated barley grass juice product. Outcomes measured were dietary intake, the fibromyalgia impact questionnaire (FIQ), SF-36 health survey, a quality of life survey (QOLS), and physical performance measurements.
        
        
          Results
          Twenty-six subjects returned dietary surveys at 2 months; 20 subjects returned surveys at the beginning, end, and at either 2 or 4 months of intervention; 3 subjects were lost to follow-up. The mean FIQ score (n = 20) was reduced 46% from 51 to 28. Seven of the 8 SF-36 subscales, bodily pain being the exception, showed significant improvement (n = 20, all P for trend < 0.01). The QOLS, scaled from 0 to 7, rose from 3.9 initially to 4.9 at 7 months (n = 20, P for trend 0.000001). Significant improvements (n = 18, P < 0.03, paired t-test) were seen in shoulder pain at rest and after motion, abduction range of motion of shoulder, flexibility, chair test, and 6-minute walk. 19 of 30 subjects were classified as responders, with significant improvement on all measured outcomes, compared to no improvement among non-responders. At 7 months responders' SF-36 scores for all scales except bodily pain were no longer statistically different from norms for women ages 45–54.
        
        
          Conclusion
          This dietary intervention shows that many fibromyalgia subjects can be helped by a mostly raw vegetarian diet.
Decreased inducibility of TNF expression in lipid-loaded macrophages

Background
          Inflammation and immune responses are considered to be very important in the pathogenesis of atherosclerosis. Lipid accumulation in macrophages of the arterial intima is a characteristic feature of atherosclerosis which can influence the inflammatory potential of macrophages. We studied the effects of lipid loading on the regulation of TNF expression in human monocyte-derived macrophages.
        
        
          Results
          In macrophages incubated with acetylated low density lipoprotein (ac-LDL) for 2 days, mRNA expression of TNF in cells stimulated with TNF decreased by 75%. In cell cultures stimulated over night with IL-1β, lipid loading decreased secretion of TNF into culture medium by 48%. These results suggest that lipid accumulation in macrophages makes them less responsive to inflammatory stimuli. Decreased basal activity and inducibility of transcription factor AP-1 was observed in lipid-loaded cells, suggesting a mechanism for the suppression of cytokine expression. NF-κB binding activity and inducibility were only marginally affected by ac-LDL. LDL and ac-LDL did not activate PPARγ. In contrast, oxidized LDL stimulated AP-1 and PPARγ but inhibited NF-κB, indicating that the effects of lipid loading with ac-LDL were not due to oxidation of lipids.
        
        
          Conclusions
          Accumulation of lipid, mainly cholesterol, results in down-regulation of TNF expression in macrophages. Since monocytes are known to be activated by cell adhesion, these results suggest that foam cells in atherosclerotic plaques may contribute less potently to an inflammatory reaction than newly arrived monocytes/macrophages.
Compound 528408: Oxazole, 4-methyl-2,5-dipropyl

Chemical compound data from PubChem database. IUPAC Name: 4-methyl-2,5-dipropyl-1,3-oxazole. Molecular Formula: C10H17NO. Molecular Weight: 167.25. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Hospital Inpatient Prevention Quality Indicators (PQI) for Adult Discharges by County (SPARCS): Calendar Year 2015

This is one of two datasets that contain observed and expected rates for Agency for Healthcare Research and Quality Prevention Quality Indicators – Adult (AHRQ PQI) for calendar year 2015. This dataset is at the county level. The Agency for Healthcare Research and Quality (AHRQ) Prevention Quality Indicators (PQIs) are a set of population based measures that can be used with hospital inpatient discharge data to identify ambulatory care sensitive conditions. These are conditions where 1) the need for hospitalization is potentially preventable with appropriate outpatient care, or 2) conditions that could be less severe if treated early and appropriately. All PQIs apply only to adult populations (over the age of 18 years). The rates were calculated using Statewide Planning and Research Cooperative System (SPARCS) inpatient data and Claritas population information.
The observed rates and expected rates for each AHRQ PQI is presented by either resident county (including a statewide total) or resident zip code (including a statewide total).
MedlinePlus Connect for Electronic Health Record (EHR) Systems - Web Service

<p>A Web service that allows patient portals and electronic health record (EHR) systems to use existing code sets to link to relevant, authoritative health information from MedlinePlus.gov. Matches ICD-9-CM or SNOMED CT codes to related MedlinePlus consumer health information, LOINC codes to information on lab tests, and also matches NDC, RXCUI or text strings to patient medication information.</p>