AndreaBozzo/ceres-open-data-index huggingface dataset:
Quality Assessment of the 2014 to 2019 NSDUH Public Use Files

Explore the data quality of the 2014-2019 National Survey on Drug Use and Health (NSDUH) Public Use Files (PUFs) and its comparability with the NSDUH Restricted Use Files (RUFs). This report demonstrates the overall quality of the NSDUH PUFs and the statistical disclosure control techniques used to create them.Chapters:Describes NSDUH and lays out the objective of the report.Presents an overview of the NSDUH disclosure concerns, briefly discusses the disclosure technique known as Micro Agglomeration, Substitution, Subsampling, and Calibration (MASSC), and provides a summary of this study’s quality assessment and research methods.Discusses how some of the detailed tables based on RUF data were selected and replicated using PUF data.Describes the data quality assessment results and findings.Summarizes the conclusions.There are also five appendices that support the analysis further.Aprevious reportanalyzed the PUF data from 2002-2013.
Policy mapping for establishing a national emergency health policy for Nigeria

Background
          The number of potential life years lost due to accidents and injuries though poorly studied has resulted in tremendous economic and social loss to Nigeria. Numerous socio-cultural, economic and political factors including the current epidemic of ethnic and religious conflicts act in concert in predisposing to and enabling the ongoing catastrophe of accident and injuries in Nigeria.
        
        
          Methods
          Using the "policymaker", Microsoft-Windows® based software, the information generated on accidents and injuries and emergency health care in Nigeria from literature review, content analysis of relevant documents, expert interviewing and consensus opinion, a model National Emergency Health Policy was designed and analyzed. A major point of analysis for the policy is the current political feasibility of the policy including its opportunities and obstacles in the country.
        
        
          Results
          A model National Emergency Health Policy with policy goals, objectives, programs and evaluation benchmarks was generated. Critical analyses of potential policy problems, associated multiple players, diverging interests and implementation guidelines were developed.
        
        
          Conclusions
          "Political health modeling" a term proposed here would be invaluable to policy makers and scholars in developing countries in assessing the political feasibility of policy managing. Political modeling applied to the development of a NEHP in Nigeria would empower policy makers and the policy making process and would ensure a sustainable emergency health policy in Nigeria.
Compound 528398: Butanamine, 2-methyl-N-(3-methylbutylidene)

Chemical compound data from PubChem database. IUPAC Name: 3-methyl-N-(2-methylbutyl)butan-1-imine. Molecular Formula: C10H21N. Molecular Weight: 155.28. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Custodial Parents Living in Poverty

<p>Office of Child Support Enforecment (OCSE) Story Behind the Numbers - Child Support Fact Sheet #3.  This fact sheet focuses on data reported in a recent U.S. Census Bureau report, Custodial Mothers and Fathers and Their Child Support: 2011. The data reported are estimated based on a biennial survey of custodial parents, the Child Support Supplement to the Current Population Survey, March/April 2012, co-sponsored by the Office of Child Support Enforcement.  The proportion of custodial parents living below poverty line continues to increase in 2011. The report found that 4.2 million custodial parents lived in poverty in 2011, representing 29 percent of all custodial parents, about twice the poverty rate for the total population. These statistics reinforce the essential role that child support services can play in helping low-income families, especially during an economic downturn.</p>
National Health Interview Survey (NHIS) – Vision and Eye Health Surveillance

2014-15 merged, 2016-17 merged. This dataset is a de-identified summary table of vision and eye health data indicators from NHIS, stratified by all available combinations of age group, race/ethnicity, gender, and risk factor. NHIS is an annual household survey conducted by the National Center for Health Statistics at CDC that monitors trends in illness, disabilities, and progress towards national health objectives. Approximate sample size is 35,000 households and 87,500 persons annually. NHIS data for VEHSS includes questions related to Visual Function. Data were suppressed for cell sizes less than 30 persons, or where the relative standard error more than 30% of the mean. Data will be updated as it becomes available. Detailed information on VEHSS NHIS analyses can be found on the VEHSS NHIS webpage (link). Additional information about NHIS can be found on the NHIS website (http://www.cdc.gov/nchs/nhis/about_nhis.htm). The VEHSS NHIS dataset was last updated in November 2019.
Ileal mucosal bile acid absorption is increased in Cftr knockout mice

Background
          Excessive loss of bile acids in stool has been reported in patients with cystic fibrosis. Some data suggest that a defect in mucosal bile acid transport may be the mechanism of bile acid malabsorption in these individuals. However, the molecular basis of this defect is unknown. This study examines the expression of the ileal bile acid transporter protein (IBAT) and rates of diffusional (sodium independent) and active (sodium dependent) uptake of the radiolabeled bile acid taurocholate in mice with targeted disruption of the cftr gene.
        
        
          Methods
          Wild-type, heterozygous cftr (+/-) and homozygous cftr (-/-) mice were studied. Five one-cm segments of terminal ileum were excised, everted and mounted onto thin stainless steel rods and incubated in buffer containing tracer 3H-taurocholate. Simultaneously, adjacent segments of terminal ileum were taken and processed for immunohistochemistry and Western blots using an antibody against the IBAT protein.
        
        
          Results
          In all ileal segments, taurocholate uptake rates were fourfold higher in cftr (-/-) and two-fold higher in cftr (+/-) mice compared to wild-type mice. Passive uptake was not significantly higher in cftr (-/-) mice than in controls. IBAT protein was comparably increased. Immuno-staining revealed that the greatest increases occurred in the crypts of cftr (-/-) animals.
        
        
          Conclusions
          In the ileum, IBAT protein densities and taurocholate uptake rates are elevated in cftr (-/-) mice > cftr (+/-) > wild-type mice. These findings indicate that bile acid malabsorption in cystic fibrosis is not caused by a decrease in IBAT activity at the brush border. Alternative mechanisms are proposed, such as impaired bile acid uptake caused by the thick mucus barrier in the distal small bowel, coupled with a direct negative regulatory role for cftr in IBAT function.
Compound 527012: p-Methoxyfentanyl

Chemical compound data from PubChem database. IUPAC Name: N-(4-methoxyphenyl)-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide. Molecular Formula: C23H30N2O2. Molecular Weight: 366.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528372: Pyroglutamic acid, di-TMS

Chemical compound data from PubChem database. IUPAC Name: trimethylsilyl 5-trimethylsilyloxy-3,4-dihydro-2H-pyrrole-2-carboxylate. Molecular Formula: C11H23NO3Si2. Molecular Weight: 273.48. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 525110: 2,3-Dichloropropyl isopentanoate

Chemical compound data from PubChem database. IUPAC Name: 2,3-dichloropropyl 3-methylbutanoate. Molecular Formula: C8H14Cl2O2. Molecular Weight: 213.1. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 529021: 1-Ethyl-4-methyl-2-propylbenzene

Chemical compound data from PubChem database. IUPAC Name: 1-ethyl-4-methyl-2-propylbenzene. Molecular Formula: C12H18. Molecular Weight: 162.27. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 526936: 2-Methyl-3-furyl 1-methyl-2-oxobutyl disulphide

Chemical compound data from PubChem database. IUPAC Name: 5-[(2-methylfuran-3-yl)disulfanyl]heptan-3-one. Molecular Formula: C12H18O2S2. Molecular Weight: 258.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E399568-T1: [Translated] METHOD FOR MEASURING EPITHELIAL CELL LOSS

A method for detecting abnormal cell shedding rates of mature epithelial cells of a warm-blooded animal, such as the epithelial cells of the gastric or colonic glands. A labeling composition containing, e.g., a cyanine dye is applied to epithelial cells, following which the site is observed over time. Abnormal cell shedding rates are indicative of disease states such as carcinoma.
Leukocyte trafficking in alveoli and airway passages

Many pulmonary diseases preferentially affect the large airways or the alveoli. Although the mechanisms are often particular to each disease process, site-specific differences in leukocyte trafficking and the regulation of inflammation also occur. Differences in the process of margination, sequestration, adhesion, and migration occur that can be attributed to differences in anatomy, hemodynamics, and the expression of proteins. The large airways are nourished by the bronchial circulation, whereas the pulmonary circulation feeds the distal lung parenchyma. The presence of different cell types in large airways from those in alveoli might contribute to site-specific differences in the molecular regulation of the inflammatory process.
Patent AT-E399902-T1: [Translated] EMBEDDED RAIL

The system has a rail (1) and a coating girdle coating longitudinally sides of the rail. The girdle rests in a groove (3) formed by a profile (2) or realized in a form of beam or concrete platform. The girdle has a lower layer (4) with a soft coating material stretching under a base of the rail to coat the base, and an upper layer (5) with a rigid coating material to coat the rail till a head of the rail.
Classification and evolutionary history of the single-strand annealing proteins, RecT, Redβ, ERF and RAD52

Background
          The DNA single-strand annealing proteins (SSAPs), such as RecT, Redβ, ERF and Rad52, function in RecA-dependent and RecA-independent DNA recombination pathways. Recently, they have been shown to form similar helical quaternary superstructures. However, despite the functional similarities between these diverse SSAPs, their actual evolutionary affinities are poorly understood.
        
        
          Results
          Using sensitive computational sequence analysis, we show that the RecT and Redβ proteins, along with several other bacterial proteins, form a distinct superfamily. The ERF and Rad52 families show no direct evolutionary relationship to these proteins and define novel superfamilies of their own. We identify several previously unknown members of each of these superfamilies and also report, for the first time, bacterial and viral homologs of Rad52. Additionally, we predict the presence of aberrant HhH modules in RAD52 that are likely to be involved in DNA-binding. Using the contextual information obtained from the analysis of gene neighborhoods, we provide evidence of the interaction of the bacterial members of each of these SSAP superfamilies with a similar set of DNA repair/recombination protein. These include different nucleases or Holliday junction resolvases, the ABC ATPase SbcC and the single-strand-binding protein. We also present evidence of independent assembly of some of the predicted operons encoding SSAPs and in situ displacement of functionally similar genes.
        
        
          Conclusions
          There are three evolutionarily distinct superfamilies of SSAPs, namely the RecT/Redβ, ERF, and RAD52, that have different sequence conservation patterns and predicted folds. All these SSAPs appear to be primarily of bacteriophage origin and have been acquired by numerous phylogenetically distant cellular genomes. They generally occur in predicted operons encoding one or more of a set of conserved DNA recombination proteins that appear to be the principal functional partners of the SSAPs.
Compound 529251: 2-Propionylpyrroline

Chemical compound data from PubChem database. IUPAC Name: 1-(3,4-dihydro-2H-pyrrol-5-yl)propan-1-one. Molecular Formula: C7H11NO. Molecular Weight: 125.17. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Oklahoma (OK)

This report presents Oklahoma\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Oklahoma for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.
Compound 526486: 2,5-Diamino-2'-fluorobenzophenone

Chemical compound data from PubChem database. IUPAC Name: (2,5-diaminophenyl)-(2-fluorophenyl)methanone. Molecular Formula: C13H11FN2O. Molecular Weight: 230.24. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
High-susceptibility of photosynthesis to photoinhibition in the tropical plant

Background
          The tropical plant Ficus microcarpa L. f. cv. Golden Leaves (GL) is a high-light sensitive tropical fig tree in which sun-leaves are yellow and shade-leaves are green. We compared the response of photosynthetic activities to strong light between GL and its wild-type (WT, Ficus microcarpa L. f.).
        
        
          Results
          Field measurements of maximum photosystem II (PSII) efficiency (Fv/Fm) of intact sun-leaves in GL showed that photo synthetic activity was severely photoinhibited during the daytime (Fv/Fm = 0.46) and subsequently recovered in the evening (Fv/Fm = 0.76). In contrast, WT did not show any substantial changes of Fv/Fm values throughout the day (between 0.82 and 0.78). Light dependency of the CO2 assimilation rate in detached shade-leaves of GL showed a response similar to that in WT, suggesting no substantial difference in photosynthetic performance between them. Several indicators of photoinhibition, including declines in PSII reaction center protein (D1) content, Fv/Fm value, and O2 evolution and CO2 assimilation rates, all indicated that GL is much more susceptible to photoinhibition than WT. Kinetics of PAM chlorophyll a fluorescence revealed that nonphotochemical quenching (NPQ) capacity of GL was lower than that of WT.
        
        
          Conclusion
          We conclude that the photosynthetic apparatus of GL is more highly susceptible to photoinhibition than that of WT.
Compound 528096: Butanoic acid, DMTBS

Chemical compound data from PubChem database. IUPAC Name: [tert-butyl(dimethyl)silyl] butanoate. Molecular Formula: C10H22O2Si. Molecular Weight: 202.37. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Vaccine Hesitancy for COVID-19: County and local estimates

Due to the change in the survey instrument regarding intention to vaccinate, our estimates for “hesitant or unsure” or “hesitant” derived from April 14-26, 2021, are not directly comparable with prior Household Pulse Survey data and should not be used to examine trends in hesitancy.

To support state and local communication and outreach efforts, ASPE developed state, county, and sub-state level predictions of hesitancy rates (https://aspe.hhs.gov/pdf-report/vaccine-hesitancy) using the most recently available federal survey data.

We estimate hesitancy rates at the state level using the U.S. Census Bureau’s Household Pulse Survey (HPS) (https://www.census.gov/programs-surveys/household-pulse-survey.html) data and utilize the estimated values to predict hesitancy rates at the Public Use Microdata Areas (PUMA) level using the Census Bureau’s 2019 American Community Survey (ACS) 1-year Public Use Microdata Sample (PUMS)(https://www.census.gov/programs-surveys/acs/microdata.html). To create county-level estimates, we used a PUMA-to-county crosswalk from the Missouri Census Data Center(https://mcdc.missouri.edu/applications/geocorr2014.html). PUMAs spanning multiple counties had their estimates apportioned across those counties based on overall 2010 Census populations.

The HPS is nationally representative and includes information on U.S. residents’ intentions to receive the COVID-19 vaccine when available, as well as other sociodemographic and geographic (state, region and metropolitan statistical areas) information. The ACS is a nationally representative survey, and it provides key sociodemographic and geographic (state, region, PUMAs, county) information. We utilized data for the survey collection period May 26, 2021 – June 7, 2021, which the HPS refers to as Week 31..

PUMA COVID-19 Hesitancy Data - https://data.cdc.gov/Vaccinations/Vaccine-Hesitancy-for-COVID-19-Public-Use-Microdat/djj9-kh3p
Delta Opioid activation of the Mitogen-activated protein kinase cascade does not require transphosphorylation of Receptor Tyrosine Kinases

Background
          In this study, we investigated the mechanism(s) by which delta opioids induce their potent activation of extracellular signal-regulated protein kinases (ERKs) in different cell lines expressing the cloned δ-opioid receptor (δ-OR). While it has been known for some time that OR stimulation leads to the phosphorylation of both ERK isoforms, the exact progression of events has remained elusive.
        
        
          Results
          Our results indicate that the transphosphorylation of an endogenous epidermal growth factor receptor (EGFR) in the human embryonic kidney (HEK-293) cell line does not occur when co-expressed δ-ORs are stimulated by the δ-opioid agonist, D-Ser-Leu-enkephalin-Thr (DSLET). Moreover, neither pre-incubation of cultures with the selective EGFR antagonist, AG1478, nor down-regulation of the EGFR to a point where EGF could no longer activate ERKs had an inhibitory effect on ERK activation by DSLET. These results appear to rule out any structural or catalytic role for the EGFR in the δ-opioid-mediated MAPK cascade. To confirm these results, we used C6 glioma cells, a cell line devoid of the EGFR. In δ-OR-expressing C6 glioma cells, opioids produce a robust phosphorylation of ERK 1 and 2, whereas EGF has no stimulatory effect. Furthermore, antagonists to the RTKs that are endogenously expressed in C6 glioma cells (insulin receptor (IR) and platelet-derived growth factor receptor (PDGFR)) were unable to reduce opioid-mediated ERK activation.
        
        
          Conclusion
          Taken together, these data suggest that the transactivation of resident RTKs does not appear to be required for OR-mediated ERK phosphorylation and that the tyrosine-phosphorylated δ-OR, itself, is likely to act as its own signalling scaffold.
Compound 528939: 4-(1,1,3,3-Tetramethylbutyl)phenyl-3,6-dimethyl-1-cyclohexenyl ether

Chemical compound data from PubChem database. IUPAC Name: 1-(3,6-dimethylcyclohexen-1-yl)oxy-4-(2,4,4-trimethylpentan-2-yl)benzene. Molecular Formula: C22H34O. Molecular Weight: 314.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Sample Size and Population Estimates Tables (Standard Errors and P Values) - 8.1 to 8.13

These detailed tables show standard errors for sample sizes and population estimates from the 2011 National Survey on Drug Use and Health (NSDUH). Standard errors for samples sizes and population estimates are provided by age group, gender, race/ethnicity, education level, employment status, geographic area, pregnancy status, college enrollment status, and probation/parole status.
Compound 529149: 1-Heptadecanol, DMTBS

Chemical compound data from PubChem database. IUPAC Name: N-[tert-butyl(dimethyl)silyl]heptadecan-1-amine. Molecular Formula: C23H51NSi. Molecular Weight: 369.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 527855: Oxirane, 2-methyl-3-(1-methylethyl)-

Chemical compound data from PubChem database. IUPAC Name: 2-methyl-3-propan-2-yloxirane. Molecular Formula: C6H12O. Molecular Weight: 100.16. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 527723: Propanoic acid, 2,3-dibromo, 3-methylbutyl ester

Chemical compound data from PubChem database. IUPAC Name: 3-methylbutyl 2,3-dibromopropanoate. Molecular Formula: C8H14Br2O2. Molecular Weight: 302.0. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 526722: 2-(2-(2-(2-nonyloxy-ethoxy)-ethoxy)-ethoxy)-ethanol, TMS

Chemical compound data from PubChem database. IUPAC Name: trimethyl-[2-[2-[2-(2-nonoxyethoxy)ethoxy]ethoxy]ethoxy]silane. Molecular Formula: C20H44O5Si. Molecular Weight: 392.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Weekly Parental Intent for Vaccination and Cumulative Percentage of Children 6 Months-17 Years who are up to date with the updated 2023-24 COVID-19 Vaccine

• COVID-19 vaccination coverage and parental intent among children 6 months to 17 years is assessed through the National Immunization Survey providing weekly COVID-19 vaccination coverage estimates (https://www.cdc.gov/vaccines/imz-managers/nis/about.html). 

• Weekly estimates of COVID-19 vaccination coverage and parental intent for vaccination among children through December 31, 2023, were calculated using data from the National Immunization Survey-Child COVID Module (NIS-CCM). Beginning January 2, 2024, the NIS-CCM was discontinued, and questions regarding receipt of COVID-19 vaccination among children were added to the NIS-Flu (https://www.cdc.gov/vaccines/imz-managers/nis/about.html#nis-cim). 

• Starting in September 2023, the CDC recommended the 2023-2024 updated COVID-19 vaccine to protect against serious illness from COVID-19.