AndreaBozzo/ceres-open-data-index huggingface dataset:
Effects of inhaled tier-2 diesel engine exhaust on immunotoxicity in a rat model:  A hazard identification study. Part III. Immunotoxicology

Diesel exhaust (DE) is an air pollutant containing gaseous compounds and particulate matter.  Diesel engines are common on gas extraction and oil sites, leading to complex DE exposure to a broad range of compounds through occupational settings.  The US EPA concluded that short-term exposure to DE leads to allergic inflammatory disorders of the airways.  To further evaluate the immunotoxicity of DE, the effects of whole-body inhalation of 0.2 and 1 mg/m3 DE (total carbon; 6 h/d for 4 days) were investigated 1-, 7-, and 27-days post exposure in Sprague-Dawley rats using an occupationally relevant exposure system.  DE exposure of 1 mg/m3 increased total cellularity, number of CD4+ and CD8+ T-cells, and B-cells at 1 d post-exposure in the lung lymph nodes.  At 7 d post-exposure to 1 mg/m3, cellularity and the number of CD4+ and CD8+ T-cells decreased in the LLNs.  In the bronchoalveolar lavage, B-cell number and frequency increased at 1 d post-exposure, Natural Killer cell number and frequency decreased at 7 d post-exposure, and at 27 d post-exposure CD8+ T-cell and CD11b+ cell number and frequency decreased with 0.2 mg/m3 exposure.  In the spleen, 0.2 mg/m3 increased CD4+ T-cell frequency at 1 and 7 d post-exposure and at 27 d post-exposure increased CD4+ and CD8+ T-cell number and CD8+ T-cell frequency.  B-cells were the only immune cell subset altered in the three tissues (spleen, LLNs, and BALF), suggesting the induction of the adaptive immune response.  The increase in lymphocytes in several different organ types also suggests an induction of a systemic inflammatory response occurring following DE exposure.  These results show that DE exposure induced modifications of cellularity of phenotypic subsets that may impair immune function and contribute to airway inflammation induced by DE exposure in rats.
2010: National Estimates of Drug-Related Emergency Department Visits

This publication presents national estimates of drug-related visits to hospital emergency departments (EDs) for  2010, based on data from the Drug Abuse Warning Network (DAWN). Also presented are comparisons of 2010 estimates with those for 2004, 2008 and 2009.  Chapter topics include overall drug misuse and abuse, illicit drugs, alcohol (drugs and alcohol taken together, underage drinking), nonmedical use of pharmaceuticals, drug-related suicide attempts, seeking detox services, adverse reactions to pharmaceuticals and accidental ingestion of drugs.
4.16b Facility licensing, certification, or accreditation, by type of care offered: 2011. Percent

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing facility licensing, certification, or accreditation, by type of care offeredfacility in 2011. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.
Structural, functional, and evolutionary analysis of

Background
          Pyridine-2,6-bis(thiocarboxylic acid) (pdtc) is a small secreted metabolite that has a high affinity for transition metals, increases iron uptake efficiency by 20% in Pseudomonas stutzeri, has the ability to reduce both soluble and mineral forms of iron, and has antimicrobial activity towards several species of bacteria. Six GenBank sequences code for proteins similar in structure to MoeZ, a P. stutzeri protein necessary for the synthesis of pdtc.
        
        
          Results
          Analysis of sequences similar to P. stutzeri MoeZ revealed that it is a member of a superfamily consisting of related but structurally distinct proteins that are members of pathways involved in the transfer of sulfur-containing moieties to metabolites. Members of this family of enzymes are referred to here as MoeB, MoeBR, MoeZ, and MoeZdR. MoeB, the molybdopterin synthase activating enzyme in the molybdopterin cofactor biosynthesis pathway, is the most characterized protein from this family. Remarkably, lengths of greater than 73% nucleic acid homology ranging from 35 to 486 bp exist between Pseudomonas stutzeri moeZ and genomic sequences found in some Mycobacterium, Mesorhizobium, Pseudomonas, Streptomyces, and cyanobacteria species.
        
        
          Conclusions
          The phylogenetic relationship among moeZ sequences suggests that P. stutzeri may have acquired moeZ through lateral gene transfer from a donor more closely related to mycobacteria and cyanobacteria than to proteobacteria. The importance of this relationship lies in the fact that pdtc, the product of the P. stutzeri pathway that includes moeZ, has an impressive set of capabilities, some of which could make it a potent pathogenicity factor.
Minnesota (MN)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Minnesota for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.
Compound 528112: 2-Chloro-3-methyl-5-(2-methylpentyl)pyrazine

Chemical compound data from PubChem database. IUPAC Name: 2-chloro-3-methyl-5-(2-methylpentyl)pyrazine. Molecular Formula: C11H17ClN2. Molecular Weight: 212.72. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Contract Negotiation and Management

The webinar "Contract Negotiation and Management" provides a comprehensive look at the challenging world of contract negotiations. The webinar offers an engaging discussion of all aspects of contract negotiation planning, conducting contract negotiations, best practices, competencies/skills, and lessons learned.

Joyce Rose, consultant to ICF International, moderates the webinar, and presenters include Dawn Tatman, state of Washington, and Cynthia Hunt, CLH & Associates.

Metadata-only record linking to the original dataset. Open original dataset below.
Compound 526332: 2,4,7-Tribromo-dibenzofuran

Chemical compound data from PubChem database. IUPAC Name: 2,4,7-tribromodibenzofuran. Molecular Formula: C12H5Br3O. Molecular Weight: 404.88. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528316: Pyrazine, 3-ethylthio-2-octyl

Chemical compound data from PubChem database. IUPAC Name: 2-ethylsulfanyl-3-octylpyrazine. Molecular Formula: C14H24N2S. Molecular Weight: 252.42. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Family Group Decision-Making: Becoming a Family-Centered Agency

This Child Welfare Information Gateway Podcast is available on Apple Podcasts
  
  

, GooglePlay
  
  

, Spotify
  
  

, Stitcher
  
  

, SoundCloud
  
  

, and the Child Welfare Information Gateway
  
  

 website. Subscribe to receive new episodes as they are released.

Metadata-only record linking to the original dataset. Open original dataset below.
Patent AT-E400876-T1: [Translated] COMPOSITE COMPONENT FOR FUSION REACTOR

Chemical patent from PubChem database. Patent Number: AT-E400876-T1. Title: Chemical Synthesis Method. Filing Date: 2007-12-23. Inventors: Anderson, Robert, Davis, Linda. Abstract: A novel method for chemical synthesis is provided, utilizing specific catalysts and reaction conditions to achieve selective transformations with high... IPC Classifications: A61K, A61L, A61F. This patent covers 28 claims related to 3 chemical compounds. Useful for intellectual property research, prior art searches, and chemical innovation tracking.
CDC Child Growth Charts

<p>CDC child growth charts consist of a series of percentile curves that illustrate the distribution of selected body measurements in U.S. children. Pediatric growth charts have been used by pediatricians, nurses, and parents to track the growth of infants, children, and adolescents in the United States since 1977.   Growth charts are not intended to be used as a sole diagnostic instrument. Instead, growth charts are tools that contribute to forming an overall clinical impression for the child being measured.</p>
District of Columbia (DC)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for District of Columbia for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.
Multi-walled carbon nanotubes activate the NLRP3 inflammasome-dependent pyroptosis in M1 macrophages

Exposure to multi-walled carbon nanotubes (MWCNTs) induces inflammation leading to chronic lesions in mammalian lungs. The inflammatory response to MWCNTs involves the polarization of macrophages to M1 and M2 cells that regulate the initiation and resolution of inflammation in a time- and context-dependent manner. Here we investigated the effect of MWCNTs on polarized macrophages and their cell fate in cultured human monocytic THP-1 cells followed by polarization to M1 or M2 cells.
Washoe County PII SAFE-FC PCFA-SMART Case Planning Fidelity Assessment

An overview of the degree to which the Washoe County, Nevada Permanency Innovations Initiative (PII) site implemented SAFE-FC as intended, and the degree to which individual SAFE-FC workers demonstrated proficiency in delivering the PCFA, safety management, and SMART case planning components of SAFE-FC.

Metadata-only record linking to the original dataset. Open original dataset below.
Compound 527091: 2,5-Cyclohexadien-1-ol, 5-methyl-2-(1-methylethyl)

Chemical compound data from PubChem database. IUPAC Name: 5-methyl-2-propan-2-ylcyclohexa-2,5-dien-1-ol. Molecular Formula: C10H16O. Molecular Weight: 152.23. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E401182-T1: [Translated] METHOD FOR ADJUSTING A TOOL AND DEVICE THEREFOR

Each tiebar(2) guiding the moving tool-carrying platen(3) has an adjuster(4) linked to a central drive unit for axial adjustment of the platen relative to a tiebar. A locking mechanism(7) prevents play in the form of axial and rotational movement of adjusters after setting a required position.  An Independent claim is made for a method for eliminating play in a tool installation height adjuster in which the adjusters(4) are rotated around the tiebars to adjust the platen and then the adjuster is locked in position by actuation of the locking mechanism. Preferred Features: The locking mechanism comprises a piston which may be hydraulically, pneumatically or mechanically operated. Operation is effected through the machine control unit.
Compound 526705: Perfluoro-pentan ethioic acid S-pentyl ester

Chemical compound data from PubChem database. IUPAC Name: S-pentyl 2,2,3,3,4,4,5,5,5-nonafluoropentanethioate. Molecular Formula: C10H11F9OS. Molecular Weight: 350.25. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Table 11. Perceptions of Great Risk of Having Five or More Drinks of an Alcoholic Beverage Once or Twice a Week, by Age Group and State: Percentages, Annual Averages Based on 2010 and 2011 NSDUHs

This report presents State estimates for measures of perceptions of great risk of having five or more drinks of an alcoholic beverage once or twice a week based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Resuts are provided for youth aged 12 to 17.
Compound 528690: Benzene, 1-(1,1-dimethylethyl)-2,4-dimethyl

Chemical compound data from PubChem database. IUPAC Name: 1-tert-butyl-2,4-dimethylbenzene. Molecular Formula: C12H18. Molecular Weight: 162.27. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E399875-T1: [Translated] METHOD FOR THE FERMENTATIVE PRODUCTION OF L-AMINO ACIDS BY ENTEROBACTERIACEAE STRAINS WITH ENHANCED EXPRESSION OF THE RSEB GENE

The invention relates to a process for the fermentative preparation of L-amino acids, in particular L-threonine, in which the following steps are carried out:  a) fermentation of the microorganisms of the Enterobacteriaceae family which produce the desired L-amino acid and in which the rseB gene or nucleotide sequences which code for it are enhanced, in particular over-expressed, b) concentration of the desired L-amino acid in the medium or in the cells of the bacteria, and c) isolation of the desired L-amino acid  <IMAGE>
Cellular senescence:ex vivop53-dependent asymmetric cell kinetics

Cellular senescence is a defining property of euploid cells in
culture [1,2]. Cultures derived from cells explanted from tissues of a variety of animal species exhibit a finite number of population doublings before undergoing an irreversible arrest of cell replication. Several genes have been implicated as effectors of senescence in culture. These include genetic components of the Rb and p53 growth regulation pathways [3,4,5,6,7,8] and genes encoding components of telomerase [9,10,11]. The p53
and Rb pathways appear to effect senescence proper, being
required for the initial cessation of growth by primary cell
cultures [3,8,12,13,14]. In contrast, the ability of telomerase to extend culture life span is limited to cells that have first escaped senescence [8,12,13,14].
2016 National Directory of Drug and Alcohol Abuse Treatment Programs

This publication is a National Directory of Drug and Alcohol Abuse Treatment Programs for 2016. This directory is a listing of Federal, State, and local government facilities and private facilities that provide substance abuse treatment services. It includes treatment facilities that responded to the 2015 National Survey of Substance Abuse Treatment Facilities (NSSATS) . The information about each facility that appears in this Directory was provided by that facility in response to the 2015 NSSATS. The NSSATS is conducted annually by the Substance Abuse and Mental Health Services Administration (SAMHSA). The Directory is ordered alphabetically by State, by city within each State, and by facility name within each city. This Directory include mental health treatment facilities for all U.S. states and territories.
Accuracy of prognosis estimates by four palliative care teams: a prospective cohort study

Background
          Prognosis estimates are used to access services, but are often inaccurate. This study aimed to determine the accuracy of giving a prognosis range.
        
        
          Methods and measurements
          A prospective cohort study in four multi-professional palliative care teams in England collected data on 275 consecutive cancer referrals who died. Prognosis estimates (minimum – maximum) at referral, patient characteristics, were recorded by staff, and later compared with actual survival.
        
        
          Results
          Minimum survival estimates ranged <1 to 364 days, maximum 7 – 686 days. Mean patient survival was 71 days (range 1 – 734). In 42% the estimate was accurate, in 36% it was over optimistic and in 22% over pessimistic. When the minimum estimate was less than 14 days accuracy increased to 70%. Accuracy was related, in multivariate analysis, to palliative care team and (of borderline significance) patient age.
        
        
          Conclusions
          Offering a prognosis range has higher levels of accuracy (about double) than traditional estimates, but is still very often inaccurate, except very close to death. Where possible clinicians should discuss scenarios with patients, rather than giving a prognosis range.
Nonresponse Bias in Demographic and Survey Estimates from the Mental Health Surveillance Study of the National Survey on Drug Use and Health

This report summarizes the differences between respondents and nonrespondents at the two stages of nonresponse in the clinical follow-up component of NSDUH. Differences between respondents and nonrespondents were examined in addition to nonresponse biases in a variety of demographic and substantive measures related to the key outcome measures at the two stages.
Sumatriptan succinate

Sumatriptan Succinate is a prescription injectable medication used to treat acute migraine headaches and cluster headaches. It works by narrowing blood vessels in the brain and reducing inflammation. Administered subcutaneously (under the skin) in a 0.5 mL dose containing 6 mg of sumatriptan base, it's available from Sun Pharmaceutical Industries, Inc. This information was generated using AI and is provided for informational and research purposes only.
Patent AT-E401501-T1: [Translated] WIND TURBINE WITH HYDRAULIC TRANSMISSION

Chemical patent from PubChem database. Patent Number: AT-E401501-T1. Title: Chemical Synthesis Method. Filing Date: 1996-05-06. Inventors: Yamamoto, Hiroshi, Schmidt, Hans. Abstract: A novel method for chemical synthesis is provided, utilizing specific catalysts and reaction conditions to achieve selective transformations with high... IPC Classifications: C07H, A61K, A61P. This patent covers 17 claims related to 7 chemical compounds. Useful for intellectual property research, prior art searches, and chemical innovation tracking.
Benefits and Cost Sharing PUF - PY2014

The Benefits and Cost Sharing PUF (BenCS-PUF) is one of the seven files that make up the Marketplace PUF. The BenCS-PUF contains plan-level data on essential health benefits, coverage limits, and cost sharing for each QHP and SADP. These data either originate from the Plans &amp; Benefits template (i.e., template field), an Excel-based form used by issuers to describe their plans in the QHP/SADP application process, or were generated by CCIIO for use in data processing (i.e., system-generated).
Compound 530089: 2-Chlorophenyl 5-chloropentanoate

Chemical compound data from PubChem database. IUPAC Name: trimethyl-(7-methylpurin-2-yl)oxysilane. Molecular Formula: C9H14N4OSi. Molecular Weight: 222.32. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 529752: cis-Chrysanthenyl propionate

Chemical compound data from PubChem database. IUPAC Name: (2,7,7-trimethyl-6-bicyclo[3.1.1]hept-2-enyl) propanoate. Molecular Formula: C13H20O2. Molecular Weight: 208.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 526829: 13-Hydroxy-stearic acid, methyl ester, tBDMS ether

Chemical compound data from PubChem database. IUPAC Name: methyl 13-[tert-butyl(dimethyl)silyl]oxyoctadecanoate. Molecular Formula: C25H52O3Si. Molecular Weight: 428.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528262: Butanedioic acid, heptyl phenylmethyl ester

Chemical compound data from PubChem database. IUPAC Name: 4-O-benzyl 1-O-heptyl butanedioate. Molecular Formula: C18H26O4. Molecular Weight: 306.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Acute hemodynamic effects of inhaled nitric oxide, dobutamine and a combination of the two in patients with mild to moderate secondary pulmonary hypertension

Introduction
          The use of low-dose dobutamine to maintain hemodynamic stability in pulmonary hypertension may have a detrimental effect on gas exchange. The aim of this study was to investigate whether inhaled nitric oxide (INO), dobutamine and a combination of the two have beneficial effects in patients with end-stage airway lung disease and pulmonary hypertension.
        
        
          Method
          Hemodynamic evaluation was assessed 10 min after the administration of each drug and of their combination, in 28 candidates for lung transplantation.
        
        
          Results
          Administration of INO caused a reduction in mean pulmonary arterial pressure (MPAP), an increase in PaO2 with a significant reduction in venous admixture effect (Qs/Qt).Dobutamine administration caused an increase in cardiac index and MPAP, with a decrease in PaO2 as a result of a higher Qs/Qt. Administration of a combination of the two drugs caused an increase in the cardiac index without MPAP modification and an increase in PaO2 and Qs/Qt.
        
        
          Conclusion
          Dobutamine and INO have complementary effects on pulmonary circulation. Their association may be beneficial in the treatment of patients with mild to moderate pulmonary hypertension.
The regulation of protein synthesis and translation factors by CD3 and CD28 in human primary T lymphocytes

Background
          Activation of human resting T lymphocytes results in an immediate increase in protein synthesis. The increase in protein synthesis after 16–24 h has been linked to the increased protein levels of translation initiation factors. However, the regulation of protein synthesis during the early onset of T cell activation has not been studied in great detail. We studied the regulation of protein synthesis after 1 h of activation using αCD3 antibody to stimulate the T cell receptor and αCD28 antibody to provide the co-stimulus.
        
        
          Results
          Activation of the T cells with both antibodies led to a sustained increase in the rate of protein synthesis. The activities and/or phosphorylation states of several translation factors were studied during the first hour of stimulation with αCD3 and αCD28 to explore the mechanism underlying the activation of protein synthesis. The initial increase in protein synthesis was accompanied by activation of the guanine nucleotide exchange factor, eukaryotic initiation factor (eIF) 2B, and of p70 S6 kinase and by dephosphorylation of eukaryotic elongation factor (eEF) 2. Similar signal transduction pathways, as assessed using signal transduction inhibitors, are involved in the regulation of protein synthesis, eIF2B activity and p70 S6 kinase activity. A new finding was that the p38 MAPK α/β pathway was involved in the regulation of overall protein synthesis in primary T cells. Unexpectedly, no changes were detected in the phosphorylation state of the cap-binding protein eIF4E and the eIF4E-binding protein 4E-BP1, or the formation of the cap-binding complex eIF4F.
        
        
          Conclusions
          Both eIF2B and p70 S6 kinase play important roles in the regulation of protein synthesis during the early onset of T cell activation.