AndreaBozzo/ceres-open-data-index huggingface dataset:
Heterogeneous nuclear ribonucleoproteins C1/C2 identified as autoantigens by biochemical and mass spectrometric methods

The antigenic specificity of an unusual antinuclear antibody pattern in three patient sera was identified after separating HeLa-cell nuclear extracts by two-dimensional (2D) gel electrophoresis and localizing the antigens by immunoblotting with patient serum. Protein spots were excised from the 2D gel and their contents were analyzed by matrix-assisted laser desorption-ionization (MALDI) or nanoelectrospray ionization time-of-flight (TOF) tandem mass spectrometry (MS) after in-gel digestion with trypsin. A database search identified the proteins as the C1 and C2 heterogeneous nuclear ribonucleoproteins. The clinical spectrum of patients with these autoantibodies includes arthritis, psoriasis, myositis, and scleroderma. None of 59 patients with rheumatoid arthritis, 19 with polymyositis, 33 with scleroderma, and 10 with psoriatic arthritis had similar antibodies. High-resolution protein-separation methods and mass-spectrometric peptide mapping in combination with database searches are powerful tools in the identification of novel autoantigen specificities.
Number of opioid-related overdose deaths 2013 - 2022

Total number of opioid related unintentional intoxication overdose deaths occurring in the state of Maryland, Calendar Years 2013-2022.  <a href ="https://health.maryland.gov/docs/Total%20Number%20of%20Opioid%20Related%20Intoxication%20Deaths%20Occurring%20in%20Maryland,%202013-2022.pdf" > Link to Data Details </a>
Program Instruction (PI-18-12)

This Program Instruction (PI) provides State, Territorial, and Tribal title IV-E agencies (hereafter, "title IV-E agencies") with the revised form and instructions approved by the U.S. Office of Management and Budget (OMB) for reporting quarterly financial information on the title IV-E Foster Care, Adoption Assistance, and Guardianship Assistance, Kinship Navigator and Prevention Services Programs. This PI also provides continuing guidance for the submission of the Annual Adoption Savings Calculation and Accounting Report.

Metadata-only record linking to the original dataset. Open original dataset below.
Georgia (GA)

This report presents Georgia\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Georgia for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.
Table 14. 2011-2012 NSDUH Cigarette Use in the Past Month, by Age Group and State

Table 14. Cigarette Use in the Past Month, by Age Group and State: Percentages, Annual Averages Based on 2011 and 2012 NSDUHs. Results are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.
2012-2013 NSDUH State Estimates of Substance Use and Mental Disorders

State estimates for 25 measures of substance use and mental disorders based on the combined 2012 and 2013 National Surveys on Drug Use and Health (NSDUHs) are provided. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Results are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older, and all persons 12 or older. State and cenusus region estimates are based on a small area estimation (SAE) methodology in which State-level NSDUH data are combined with county and census block group/tract-level data from the State.
Compound 525600: N,N-Dimethyl-N'-(4-methoxyphenyl)-p-methoxybenzamidine

Chemical compound data from PubChem database. IUPAC Name: 4-methoxy-N'-(4-methoxyphenyl)-N,N-dimethylbenzenecarboximidamide. Molecular Formula: C17H20N2O2. Molecular Weight: 284.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E401409-T1: [Translated] METHOD AND VECTORS FOR PRODUCING TRANSGENIC PLANTS

Chemical patent from PubChem database. Patent Number: AT-E401409-T1. Title: Improved Chemical Process. Filing Date: 2013-12-25. Inventors: Chen, Wei, Kumar, Raj, Williams, Sarah. Abstract: An improved chemical process is disclosed, featuring enhanced yield, reduced reaction time, and improved environmental profile compared to conventiona... IPC Classifications: C07K, A61K, G01N. This patent covers 34 claims related to 4 chemical compounds. Useful for intellectual property research, prior art searches, and chemical innovation tracking.
Compound 526181: 1,3-Dimethylbicyclo[3.3.0]-2,8-dioxa-4-thiaoctane

Chemical compound data from PubChem database. IUPAC Name: 2,3a-dimethyl-6,6a-dihydro-5H-furo[3,2-d][1,3]oxathiole. Molecular Formula: C7H12O2S. Molecular Weight: 160.24. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 526346: 3,4,6,7-Tetrabromo-dibenzofuran

Chemical compound data from PubChem database. IUPAC Name: 3,4,6,7-tetrabromodibenzofuran. Molecular Formula: C12H4Br4O. Molecular Weight: 483.77. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E400474-T1: [Translated] VOICE RECOGNITION SYSTEM IN A MOTOR VEHICLE

The present invention relates to a system for automatic adjustment of at least one element provided with at least one actuator and provided inside or outside a vehicular cabin, comprising at least one microphone array for detecting utterances of at least one speaker and for obtaining microphone signals corresponding to the utterances, localization means configured to determine the position of the at least one speaker on the basis of the microphone signals and to output at least one localization signal and control means configured to receive the at least one localization signal and to automatically control the at least one actuator of the at least one element on the basis of the at least one localization signal. The invention also relates to Method for automatically adjusting at least one element provided with at least one actuator and provided inside or outside a vehicular cabin, comprising detecting utterances of at least one speaker by at least one microphone array and obtaining microphone signals corresponding to the utterances, determining the position of the at least one speaker on the basis of the microphone signals and automatically controlling the at least one actuator of the at least one element on the basis of the determined position of the at least one speaker to adjust the at least one element.
Patent AT-E400088-T1: [Translated] DEVICE WITH A FREQUENCY DIVIDER

Frequency dividers (2) comprising sections (21-27) are provided with basic sections of a first type (21,23,24) for dividing frequency signals (f") by adjustable numbers in dependence of adjustment signals (p") and in dependence of control signals (c") originating from later sections and are provided with advanced sections (22) of a second type comprising additional circuitry 55,56,64,66,67. This additional circuitry 55,56,64,66,67 allows any modulation to be performed on a limited number of earlier sections, later sections are not affected. As a result, the frequency divider (2) can be extended, for example with programmable sections (26,27) having an active and an inactive mode, without any modulating needing to be adapted. Thereto, the circuitry 55,56,64,66,67 receives modulation signals (mo,ml) and an additional control signal (c3). Such a frequency divider (2) is low cost, reliable and robust and can easily be implemented.
Compound 525887: N,N-Dimethyl-N'-(4-ethoxyphenyl)-pivalamidine

Chemical compound data from PubChem database. IUPAC Name: N'-(4-ethoxyphenyl)-N,N,2,2-tetramethylpropanimidamide. Molecular Formula: C15H24N2O. Molecular Weight: 248.36. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Modulation of L-type Ca

Background
          The multisubunit (α1S,α2-δ, β1a and γ1) skeletal muscle dihydropyridine receptor (DHPR) transduces membrane depolarization into release of Ca2+ from the sarcoplasmic reticulum (SR) and also acts as an L-type Ca2+ channel. To more fully investigate the function of the γ1 subunit in these two processes, we produced mice lacking this subunit by gene targeting.
        
        
          Results
          Mice lacking the DHPR γ1 subunit (γ1 null) survive to adulthood, are fertile and have no obvious gross phenotypic abnormalities. The γ1 subunit is expressed at approximately half the normal level in heterozygous mice (γ1 het). The density of the L-type Ca2+ current in γ1 null and γ1 het myotubes was higher than in controls. Inactivation of the Ca2+ current produced by a long depolarization was slower and incomplete in γ1 null and γ1 het myotubes, and was shifted to a more positive potential than in controls. However, the half-activation potential of intramembrane charge movements was not shifted, and the maximum density of the total charge was unchanged. Also, no shift was observed in the voltage-dependence of Ca2+ transients. γ1 null and γ1 het myotubes had the same peak Ca2+ amplitude vs. voltage relationship as control myotubes.
        
        
          Conclusions
          The L-type Ca2+ channel function, but not the SR Ca2+ release triggering function of the skeletal muscle dihydropyridine receptor, is modulated by the γ1 subunit.
Patent AT-E401836-T1: [Translated] PROSTHETIC KNITTED FABRIC WITH VARIABLE PROPERTIES

The prosthetic strip (1) is made from layers of a material made from biocompatible polymer fibres with a central (2) and two lateral (3) zones, the central zone having a greater elasticity than the lateral zones. The prosthetic strip (1) is made from layers of a material made from biocompatible polymer fibres with a central (2) and two lateral (3) zones, the central zone having a greater elasticity than the lateral zones. It has at least two basic layers, one front and one rear, extending at least over the area of the central zone, and two supplementary layers that cover the back of the lateral zones and are of a different weave to the basic layers. The surface mass of the material in the two lateral zones is at least twice as great as that of the material in the central zone, and has at least double the breaking load, i.e. about 200 N in lengthwise and transverse directions. In addition, the central zone is covered with a bioresorbable material on at least one surface. Prosthetic supports (4) with ends (5) of the required shape can be cut from the strip.
Compound 528665: 4,4-Dimethyl-3-[(trimethylsilyl)oxy]dihydro-2(3H)-furanone

Chemical compound data from PubChem database. IUPAC Name: 4,4-dimethyl-3-trimethylsilyloxyoxolan-2-one. Molecular Formula: C9H18O3Si. Molecular Weight: 202.32. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E401138-T1: [Translated] METHOD FOR COATING AUTOMOBILE RADIATORS WITH A SLURRIED OZONE DECREASE CATALYST MATERIAL

A method for coating vehicular radiators with an ozone depleting manganese oxide catalyst in slurry form utilizes a robotic arm with multiple spray heads for spraying the face of the radiator. Each head is in fluid communication with its own dedicated peristaltic pump. The pumps are independently valved into and out of fluid communication with select heads as a function of the spray pattern effected by robotic arm movement.
Compound 526085: Dodecanoic acid, 11-methyl, trimethylsilyl ester

Chemical compound data from PubChem database. IUPAC Name: trimethylsilyl 11-methyldodecanoate. Molecular Formula: C16H34O2Si. Molecular Weight: 286.52. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Cloning, expression and nuclear localization of human

Background
          Studies suggest that the related proteins nucleoplasmin and nucleophosmin (also called B23, NO38 or numatrin) are nuclear chaperones that mediate the assembly of nucleosomes and ribosomes, respectively, and that these activities are accomplished through the binding of basic proteins via their acidic domains. Recently discovered and less well characterized members of this family of acidic phosphoproteins include mouse nucleophosmin/nucleoplasmin 3 (Npm3) and Xenopus NO29. Here we report the cloning and initial characterization of the human ortholog of Npm3.
        
        
          Results
          Human genomic and cDNA clones of NPM3 were isolated and sequenced. NPM3 lies 5.5 kb upstream of FGF8 and thus maps to chromosome 10q24-26. In addition to amino acid similarities, NPM3 shares many physical characteristics with the nucleophosmin/nucleoplasmin family, including an acidic domain, multiple potential phosphorylation sites and a putative nuclear localization signal. Comparative analyses of 14 members of this family from various metazoans suggest that Xenopus NO29 is a candidate ortholog of human and mouse NPM3, and they further group both proteins closer with the nucleoplasmins than with the nucleophosmins. Northern blot analysis revealed that NPM3 was strongly expressed in all 16 human tissues examined, with especially robust expression in pancreas and testis; lung displayed the lowest level of expression. An analysis of subcellular fractions of NIH3T3 cells expressing epitope-tagged NPM3 revealed that NPM3 protein was localized solely in the nucleus.
        
        
          Conclusions
          Human NPM3 is an abundant and widely expressed protein with primarily nuclear localization. These biological activities, together with its physical relationship to the chaparones nucleoplasmin and nucleophosmin, are consistent with the proposed function of NPM3 as a molecular chaperone functioning in the nucleus.
22nd European Workshop for Rheumatology Research, Leiden, The Netherlands, 28 February–3 March 2002

The European Workshop for Rheumatology Research met this year in Leiden, The Netherlands. The Workshop provided a platform to feast on new technologies and how they have taken research programmes forward. While there will be the inevitable delay during which mechanisms are devised for analysing the huge amount of information generated by these technologies, there is a lot already to look forward to. Highlights included genomic, reverse genomic and proteomic approaches to understanding disease pathogenesis and to identifying new therapeutic targets. Opportunities for exploring whether pharmacogenomics has a place in the clinic are now a reality, and phage display technology has been applied to in vivo arthritis models to identify human synovial microvascular 'post codes'.
DEV DQS Estimate of Emergency Department Visits in the United States, 2016-2022

These data include counts and rates of emergency department visits from 2016-2022 for selected primary diagnoses and reasons for visit, stratified by selected patient and hospital characteristics.
Search, visualize, and download these and other estimates from over 120 health topics with the NCHS Data Query System (DQS), available from: https://www.cdc.gov/nchs/dataquery/index.htm.
Public Health Statistics - Low birth weight in Chicago, by year, 1999 – 2009 - Historical

Note: This dataset is historical only and there are not corresponding datasets for more recent time periods. For that more-recent information, please visit the Chicago Health Atlas at https://chicagohealthatlas.org.

This dataset contains the annual number of low birth weight births and the percent of total births these low birth weight births represent, with corresponding 95% confidence intervals, by Chicago community area, for the years 1999 – 2009. See full description at http://bit.ly/KcNNzH
Treatment Episode Data Set (TEDS) 1994-2004 National Admissions to Substance Abuse Treatment Services

This report presents results from the Treatment Episode Data Set (TEDS) for 2004 and trend data for 1994-2004. The report provides information on the demographic and substance abuse characteristics of the 1.9 million people admitted to treatment for abuse of alcohol and drugs in 2004 to facilities that report to individual state administrative data systems.
Compound 525565: N,N-Dimethyl-N'-(3-chlorophenyl)-benzamidine

Chemical compound data from PubChem database. IUPAC Name: N'-(3-chlorophenyl)-N,N-dimethylbenzenecarboximidamide. Molecular Formula: C15H15ClN2. Molecular Weight: 258.74. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 526577: 2,16,24-Trimethyltetratriacontane

Chemical compound data from PubChem database. IUPAC Name: 2,16,24-trimethyltetratriacontane. Molecular Formula: C37H76. Molecular Weight: 521.0. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 526352: 3,6,8-Tribromo-1,2,9-trichloro-dibenzo-p-dioxin

Chemical compound data from PubChem database. IUPAC Name: 3,6,8-tribromo-1,2,9-trichlorodibenzo-p-dioxin. Molecular Formula: C12H2Br3Cl3O2. Molecular Weight: 524.2. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
2010 CMHS Uniform Reporting System (URS) Output Tables for Washington, DC

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
Intraocular pressure in genetically distinct mice: an update and strain survey

Background
          Little is known about genetic factors affecting intraocular pressure (IOP) in mice and other mammals. The purpose of this study was to determine the IOPs of genetically distinct mouse strains, assess the effects of factors such as age, sex and time of day on IOP in specific strain backgrounds, and to assess the effects of specific candidate gene mutations on IOP.
        
        
          Results
          Based on over 30 studied mouse strains, average IOP ranges from approximately 10 to 20 mmHg. Gender does not typically affect IOP and aging results in an IOP decrease in some strains. Most tested strains exhibit a diurnal rhythm with IOP being the highest during the dark period of the day. Homozygosity for a null allele of the carbonic anhydrase II gene (Car2n) does not alter IOP while homozygosity for a mutation in the leptin receptor gene (Leprdb) that causes obesity and diabetes results in increased IOP. Albino C57BL/6J mice homozygous for a tyrosinase mutation (Tyrc-2J) have higher IOPs than their pigmented counterparts.
        
        
          Conclusions
          Genetically distinct mouse strains housed in the same environment have a broad range of IOPs. These IOP differences are likely due to interstrain genetic differences that create a powerful resource for studying the regulation of IOP. Age, time of day, obesity and diabetes have effects on mouse IOP similar to those in humans and other species. Mutations in two of the assessed candidate genes (Lepr and Tyr) result in increased IOP. These studies demonstrate that mice are a practical and powerful experimental system to study the genetics of IOP regulation and disease processes that raise IOP to harmful levels.
Incidence Tables (Standard Errors and P Values) - 4.1 to 4.16

These detailed tables present standard errors for totals and prevalence estimates of substance use initiation from the 2010 National Survey on Drug Use and Health (NSDUH). Substances examined include illicit drugs (e.g., marijuana, cocaine, heroin, hallucinogens (including LSD, PCP, Ecstasy), inhalants, and the nonmedical use of prescription-type pain relievers (including OxyContin), tranquilizers, stimulants, sedatives, alcohol, and tobacco products (including cigarettes, smokeless tobacco, and cigars). Standard errors are provided by age group and gender. Standard errors are provided for both 2010 and 2009.
Compound 527587: 2-Propyl-1-ol, dichloroacetate

Chemical compound data from PubChem database. IUPAC Name: prop-2-ynyl 2,2-dichloroacetate. Molecular Formula: C5H4Cl2O2. Molecular Weight: 166.99. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
A Report to Congress on Barriers and Success Factors in Adoptions from Foster Care: Perspectives of Families and Staff Supported by the Adoption Opportunities Program

This report outlines the findings of two adoption-research studies conducted as part of The Collaboration to AdoptUsKids. The studies identified the child, family, and agency factors that presented as barriers or promoters of successful adoptions from foster care.

Metadata-only record linking to the original dataset. Open original dataset below.
National Child Abuse and Neglect Data System (NCANDS) Child File: Findings from the National Child Abuse and Neglect Data System (NCANDS) - File contents and definitions (from Child Maltreatment 2018)

<p>The National Child Abuse and Neglect Data System (NCANDS) Child File data set consists of child-specific data of all reports of maltreatment to State child protective service agencies that received an investigation or assessment response. NCANDS is a Federally-sponsored national data collection effort created for the purpose of tracking the volume and nature of child maltreatment reporting each year within the United States. The Child File is the case-level component of the NCANDS. Child File data are collected annually through the voluntary participation of States. Participating States submit their data after going through a process in which the State's administrative system is mapped to the NCANDS data structure.  Data elements include the demographics of children and their perpetrators, types of maltreatment, investigation or assessment dispositions, risk factors, and services provided as a result of the investigation or assessment.</p>
Pennsylvania: 2011-2012 NSDUH

This report presents Pennsylvania\'s estimates for 25 measures of substance use and mental health based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.