AndreaBozzo/ceres-open-data-index huggingface dataset:
Hisactophilin is involved in osmoprotection in Dictyostelium

Background
          Dictyostelium cells exhibit an unusual stress response as they protect themselves against hyperosmotic stress. Cytoskeletal proteins are recruited from the cytosolic pool to the cell cortex, thereby reinforcing it. In order to gain more insight into the osmoprotective mechanisms of this amoeba, we used 1-D and 2-D gel electrophoresis to identify new proteins that are translocated during osmotic shock.
        
        
          Results
          We identified hisactophilin as one of the proteins that are enriched in the cytoskeletal fraction during osmotic shock. In mutants lacking hisactophilin, viability is reduced under hyperosmotic stress conditions. In wild type cells, serine phosphorylation of hisactophilin was specifically induced by hypertonicity, but not when other stress conditions were imposed on cells. The phosphorylation kinetics reveals a slow accumulation of phosphorylated hisactophilin from 20–60 min after onset of the hyperosmotic shock condition.
        
        
          Conclusion
          In the present study, we identified hisactophilin as an essential protein for the osmoprotection of Dictyostelium cells. The observed phosphorylation kinetics suggest that hisactophilin regulation is involved in long-term osmoprotection and that phosphorylation occurs in parallel with inactivation of the dynamic actin cytoskeleton.
Compound 527272: m-Mentha-1(7),8-diene

Chemical compound data from PubChem database. IUPAC Name: 1-methylidene-3-prop-1-en-2-ylcyclohexane. Molecular Formula: C10H16. Molecular Weight: 136.23. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Gene therapy moves forward - The Second International Meeting on Gene and Cell Therapies of Arthritis and Related Disorders, 17-18 May 2001, Montpellier, France

The field of gene therapy for bone and joint disorders has grown considerably over the last two and a half years. Investigators have shown that ex vivo or in vivo gene transfer is highly effective in blocking arthritis or facilitating repair of damaged cartilage or bone. The feasibility of applying gene therapy for the treatment of arthritis in humans has also been demonstrated. Thus, gene therapy appears poised to make significant contributions to the clinical treatment of joint and bone diseases in the near future.
Compound 530325: Propyl 3-methyl-2-butenoate

Chemical compound data from PubChem database. IUPAC Name: propyl 3-methylbut-2-enoate. Molecular Formula: C8H14O2. Molecular Weight: 142.2. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Quality PUF - PY2019

The Quality PUF contains 2018 quality ratings data for eligible Qualified Health Plans in PY2019 pilot states (MI, MT, NH, VA and WI)<br />
Access the Quality PUF and Data Dictionary Here - <a href="https://edit.cms.gov/Medicare/Quality-Initiatives-Patient-Assessment-Instruments/QualityInitiativesGenInfo/Downloads/2018-QRS-Pilot-State-PUF_20181031.xlsx">Quality PUF and Data Dictionary</a>
Compound 528968: Phenol, 4-tert.-octyl-2-nitro

Chemical compound data from PubChem database. IUPAC Name: 2-nitro-4-(2,4,4-trimethylpentan-2-yl)phenol. Molecular Formula: C14H21NO3. Molecular Weight: 251.32. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Medical errors: how the US Government is addressing the problem

November's Institute of Medicine (IOM) report on medical errors has sparked debate among US health policy makers as to the appropriate response to the problem. Proposals range from the implementation of nationwide mandatory reporting with public release of performance data to voluntary reporting and quality-assurance efforts that protect the confidentiality of error-related data. Any successful safety program will require a national effort to make significant investments in information technology infrastructure, and to provide an environment and education that enables providers to contribute to an active quality-improvement process.
Compound 529102: 4H-Pyrido[1,2-a]pyrimidin-4-one, 9-methyl

Chemical compound data from PubChem database. IUPAC Name: 9-methylpyrido[1,2-a]pyrimidin-4-one. Molecular Formula: C9H8N2O. Molecular Weight: 160.17. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
A cross-sectional study of early identification of postpartum depression: Implications for primary care providers from The Ontario Mother & Infant Survey

Background
          This survey's objective was to provide planning information by examining utilization patterns, health outcomes and costs associated with existing practices in the management of postpartum women and their infants. In particular, this paper looks at a subgroup of women who score ≥ 12 on the Edinburgh Postnatal Depression Survey (EPDS).
        
        
          Methods
          The design is cross-sectional with follow-up at four weeks after postpartum hospital discharge. Five Ontario hospitals, chosen for their varied size, practice characteristics, and geographic location, provided the setting for the study. The subjects were 875 women who had uncomplicated vaginal deliveries of live singleton infants. The main outcome measures were the EPDS, the Duke UNC Functional Social Support Questionnaire and the Health and Social Services Utilization Questionnaire.
        
        
          Results
          EPDS scores of ≥ 12 were found in 4.3 to 15.2% of otherwise healthy women. None of these women were being treated for postpartum depression. Best predictors of an EPDS score of ≥ 12 were lack: of confident support, lack of affective support, household income of <$20,000, wanting to stay in hospital longer, identification of learning needs while in hospital, self-identified care needs for an emotional/mental health problem that have not been met and mother's rating of own and baby's health as fair or poor.
        
        
          Conclusions
          Primary care physicians, midwives, and public health nurses need to screen for depression at every opportunity early in the postpartum period. A mother's expression of undue concern about her own or her baby's health may be predictive of postpartum depression. Flexible, mother-focused support from community providers may decrease the prevalence of postpartum depression.
Effect of Contour Shape of Nervous System Electromagnetic Stimulation Coils on the Induced Electrical Field Distribution

Background
          Electromagnetic stimulation of the nervous system has the advantage of reduced discomfort in activating nerves. For brain structures stimulation, it has become a clinically accepted modality. Coil designs usually consider factors such as optimization of induced power, focussing, field shape etc. In this study we are attempting to find the effect of the coil contour shape on the electrical field distribution for magnetic stimulation.
        
        
          Method and results
          We use the maximum of the induced electric field stimulation in the region of interest as the optimization criterion. This choice required the application of the calculus of variation, with the contour perimeter taken as a pre-set condition. Four types of coils are studied and compared: circular, square, triangular and an 'optimally' shaped contour. The latter yields higher values of the induced electrical field in depths up to about 30 mm, but for depths around 100 mm, the circular shape has a slight advantage. The validity of the model results was checked by experimental measurements in a tank with saline solution, where differences of about 12% were found. In view the accuracy limitations of the computational and measurement methods used, such differences are considered acceptable.
        
        
          Conclusion
          We applied an optimization approach, using the calculus of variation, which allows to obtain a coil contour shape corresponding to a selected criterion. In this case, the optimal contour showed higher intensities for a longer line along the depth-axis. The method allows modifying the induced field structure and focussing the field to a selected zone or line.
SHIP Drug-Induced Death Rate 2009-2021

This is historical data. The update frequency has been set to "Static Data" and is here for historic value. Updated on 8/14/2024

Drug-Induced Death Rate - This indicator shows the drug-induced death rate per 100,000 population. Drug-induced deaths include all deaths for which illicit or prescription drugs are the underlying cause. In 2007, drug-induced deaths were more common than alcohol-induced or firearm-related deaths in the United States. Between 2012-2014, there were 2793 drug-induced deaths in Maryland. <a href="https://health.maryland.gov/pophealth/Documents/SHIP/SHIP%20Lite%20Data%20Details/Drug-Induced%20Death.pdf" > Link to Data Details </a>
Patent AT-E399848-T1: [Translated] METHOD AND DEVICE FOR THE SOCIALLY LIMITED DOSAGE OF A SURFACE CLEANING AGENT

A device for applying a thickened cleaning composition to a selected surface area that minimizes or eliminates any unintentional or excess application of the composition and/or minimizes or eliminates any spreading or wicking of the composition beyond the selected surface area after application. A dispensing device featuring the combination of a thickened cleaning composition having a specified rheology and a dispenser with one or more orifices of preferred cross-sectional area that enable convenient application of a cleaning composition to the selected region of a soft or hard surface. Additionally, the dispensing device features cleaning compositions having preferred wicking rates with respect to the treated surfaces so that only the selected stained or soiled region of the surface is effectively treated, as the cleaning compositions will not spread or wick into adjacent regions of the surface where damage may occur.
Conditions Contributing to COVID-19 Deaths, by State and Age, Provisional 2020-2023

Effective September 27, 2023, this dataset will no longer be updated. Similar data are accessible from wonder.cdc.gov.

This dataset shows health conditions and contributing causes mentioned in conjunction with deaths involving coronavirus disease 2019 (COVID-19) by age group and jurisdiction of occurrence.

2022 and 2023 data are provisional. Estimates for 2020 and 2021 are based on final data.
2010 CMHS Uniform Reporting System (URS) Output Tables for California

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
Spouses and Children of U.S. Military Personnel: Results from the 2015 National Survey on Drug Use and Health

This report presents findings from the 2015 National Survey on Drug Use and Health (NSDUH) with a focus on comparing estimates related to substance use and mental health for military family members (spouses and children) with general population estimates.  The numbers of military family members included in the 2015 NSDUH were relatively small.  As a consequence, the report focuses on wives aged 18 to 49 and children aged 12 to 17.  In the general area of substance use, the report includes estimates for past year use of any illicit substances (marijuana, cocaine in any form including crack, heroin, hallucinogens, inhalants, and methamphetamine and misuse of four categories of prescription drugs -- pain relievers, tranquilizers, stimulants and sedatives), past year cigarette use, past year alcohol use (both any use and binge use), and past year treatment for substance use, including alcohol use.  In the general area of mental health, the report includes estimates for any mental illness (AMI) in the past year for wives.  For both wives and children, the report includes estimates for past year major depressive episode (MDE) and mental health service use.  For children, estimates of mental health service are reported by general treatment setting (e.g., mental health, educational, medical).  As additional years of data become available, it will be possible in future reports to include both male and female spouses and to make more detailed comparisons -- for example for more specific types of illicit substances used and for treatment received by setting, by race/ethnicity and for spouses, by employment and educational background.
Inhalation of polycarbonate emissions generated during 3D printing processes affects neuroendocrine function in male rats

Three-dimensional printing (3DP) of manufactured goods has increased in the last 10 yrs.  The increased use of this technology has resulted in questions about the health effects of inhaling emissions generated during printing.  The goal of this study was to determine if inhalation of particulate and toxic chemicals generated during printing with polycarbonate (PC) plastic affected the neuroendocrine system.  Male rats were exposed to 3D-printer emissions (500 µg/cm3) or filtered air for 1, 4, 8, 15 or 30d for 4d/week (4h/day).  The effects of these exposures on hormone concentrations, and markers of function, injury and/or oxidative stress in the olfactory bulb, hypothalamus and testes were measured after 1, 8 and 30d of exposure.  Thirty days of exposure to 3D-emissions resulted in reductions in  thyroid stimulating hormone, follicle stimulating hormone and prolactin.  These changes were accompanied by increases in markers of cell injury and reductions in active mitochondria in the olfactory bulb, gonadotropin releasing hormone cells and fibers and tyrosine hydroxylase immunolabeled fibers in the arcuate nucleus, and reductions in spermatogonium.  PC plastics contain high concentrations bisphenol A and these results are consistent with the hypothesis that the health effects of inhaling 3D-printer emissions may be due to bisphenol A.
Patent AT-E40011-T1: [Translated] CONNECTORS.

An optical fibre connector 10 to connect two optical fibres 12 comprises a ferrule 11 secured to each fibre end, and a clamping sleeve 13 of shape memory effect metal to align and clamp the ferrules 11. The shape memory effect metal is selected and trained to expand on heating above its transformation temperature. The bore 16 of the clamping sleeve 13 is arranged to make an interference fit with the ferrules 11 when below the transformation temperature, and a clearance fit when above the transformation temperature. An elastic titanium alloy compression sleeve 14 surrounding the clamping sleeve 13 provides for long-term integrity of the connector and reinforces the clamping action of the damping sleeve 13 when below its transformation temperature.
Patent AT-E400869-T1: [Translated] AUDIO IDENTIFICATION SYSTEM

A method and system for direct audio capture and identification of the captured audio. A user may then be offered the opportunity to purchase recordings directly over the Internet or similar outlet. The system preferably includes one or more user-carried portable audio capture devices that employ a microphone, analog to digital converter, signal processor, and memory to store samples of ambient audio or audio features calculated from the audio. Users activate their capture devices when they hear a recording that they would like to identify or purchase. Later, the user may connect the capture device to a personal computer to transfer the audio samples or audio feature samples to an Internet site for identification. The Internet site preferably uses automatic pattern recognition techniques to identify the captured samples from a library of recordings offered for sale. The user can then verify that the sample is from the desired recording and place an order online. The pattern recognition process uses features of the audio itself and does not require the presence of artificial codes or watermarks. Audio to be identified can be from any source, including radio and television broadcasts or recordings that are played locally.
Patent AT-E39974-T1: [Translated] AUTOMATIC LIQUID LIFT.

1. An automatic liquid-raising device with a storage tank (3) positioned above a closed working chamber (1), and a closed suction chamber (2) positioned above the storage tank (3) and having an outlet for liquid ; the working chamber (1) having a drain pipe (5) extending a certain distance downwards from its bottom and a suction-transfer pipe (7) rising from its top to the suction chamber (2) ; the storage tank (3) being connected through a charging pipe (6) to the working chamber (1) ; the suction chamber (2) having a feed pipe through which it aspirates liquid ; the charging pipe (6) having a valve (6a) for controlling the flow of liquid reaching the working chamber (1) from the storage tank (3) in dependence on the amount of liquid in the working chamber (1) ; the suction chamber (2) having a non-return valve (16) in its outlet (2a) for preventing return flow of liquid back into the suction chamber (2), characterised in that the storage tank (3) is mounted directly on top of the working chamber (1) and delivers working liquid through a charging pipe (6) to the top of the working chamber (1), the charging pipe (6) penetrating into the interior of the storage tank (3) ; the charging pipe (6) having a downwards-directed mouth (6a, 6a') cooperating with a valve plate (13, 23) actuated by a device (9, 12 or 24, 25) controlled by an actuator (9, 25) located in the working chamber (1) ; the actuator (9, 25) being connected to the valve plate (13, 23) through at least one sealed aperture (12, 24) in the separation wall (3a) between the storage tank (3) and the working chamber (1).
Compound 529319: 3-alpha-Mannobiose, octakis(trimethylsilyl) ether (isomer 1)

Chemical compound data from PubChem database. IUPAC Name: trimethyl-[[3,4,5-tris(trimethylsilyloxy)-6-[2,3,5-tris(trimethylsilyloxy)-6-(trimethylsilyloxymethyl)oxan-4-yl]oxyoxan-2-yl]methoxy]silane. Molecular Formula: C36H86O11Si8. Molecular Weight: 919.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Prescription Drugs Introduced to Market

This dataset provides data for new prescription drugs introduced to market in California with a Wholesale Acquisition Cost (WAC) that exceeds the Medicare Part D specialty drug cost threshold. Prescription drug manufacturers submit information to HCAI within a specified time period after a drug is introduced to market. Key data elements include the National Drug Code (NDC) administered by the FDA, a narrative description of marketing and pricing plans, and WAC, among other information. Manufacturers may withhold information that is not in the public domain. Note that prescription drug manufacturers are able to submit new drug reports for a prior quarter at any time. Therefore, the data set may include additional new drug report(s) from previous quarter(s).

There are two types of New Drug data sets: Monthly and Annual. The Monthly data sets include the data in completed reports submitted by manufacturers for calendar year 2025, as of April 7, 2025. The Annual data sets include data in completed reports submitted by manufacturers for the specified year. The data sets may include reports that do not meet the specified minimum thresholds for reporting.

The program regulations are available here: https://hcai.ca.gov/wp-content/uploads/2024/03/CTRx-Regulations-Text.pdf

The data format and file specifications are available here: https://hcai.ca.gov/wp-content/uploads/2024/03/Format-and-File-Specifications-version-2.0-ada.pdf

DATA NOTES: Due to recent changes in Excel capabilities, it is not recommended that you save these files to .csv format. If you do, when importing back into Excel the leading zeros in the NDC number column will be dropped. If you need to save it into a different format other than .xlsx it must be .txt
Compound 528203: Benzoic acid, 2-hydroxy, 3-(2,3-dioxypropyl), methyl ester, DTBS #2

Chemical compound data from PubChem database. IUPAC Name: methyl 2,2-ditert-butyl-4-(hydroxymethyl)-4,5-dihydro-1,3,2-benzodioxasilepine-9-carboxylate. Molecular Formula: C19H30O5Si. Molecular Weight: 366.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Advanced analysis of a

Background
          Previously, we reported effects of the cryb mutation on circadian rhythms in period and timeless gene expression within isolated peripheral Drosophila tissues. We relied on luciferase activity driven by the respective regulatory genomic elements to provide real-time reporting of cycling gene expression. Subsequently, we developed a tool kit for the analysis of behavioral and molecular cycles. Here, we use these tools to analyze our earlier results as well as additional data obtained using the same experimental designs.
        
        
          Results
          Isolated antennal pairs, heads, bodies, wings and forelegs were evaluated under light-dark cycles. In these conditions, the cryb mutation significantly decreases the number of rhythmic specimens in each case except the wing. Moreover, among those specimens with detectable rhythmicity, mutant rhythms are significantly weaker than cry+ controls. In addition, cryb alters the phase of period gene expression in these tissues. Furthermore, peak phase of luciferase-reported period and timeless expression within cry+ samples is indistinguishable in some tissues, yet significantly different in others. We also analyze rhythms produced by antennal pairs in constant conditions.
        
        
          Conclusions
          These analyses further show that circadian clock mechanisms in Drosophila may vary in a tissue-specific manner, including how the cry gene regulates circadian gene expression.
Voriconazole

Voriconazole is an antifungal medication used to treat serious fungal infections. This intravenous powder for injection, manufactured by Meitheal Pharmaceuticals Inc., comes in 200 mg vials and belongs to the azole class of antifungals. It works by inhibiting fungal growth and may interact with certain liver enzymes. This information was generated using AI and is provided for informational and research purposes only.
Nevada (NV)

This report uses 2008 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past year alcohol use disorder and illicit drug use disorder among persons aged 12 or older for Nevada overall and for substate regions within Nevada. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE).
2015 CMHS Uniform Reporting System (URS) Table for Kansas

2015 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Kansas. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.