AndreaBozzo/ceres-open-data-index huggingface dataset:
Experimental study of the morphine de-addiction properties of

Background
          Our aim was to explore the de-addiction properties of Delphinium denudatum Wall. in morphine dependent rats.
        
        
          Methods
          Charles Foster male albino rats were made morphine dependent by injecting morphine sulphate in increasing doses twice a day for 7 days. The spontaneous withdrawal signs observed 12 h after the last dose were quantified by the 'counted' and 'checked' signs. The drug (alcoholic extract of Delphinium denudatum) was administered p.o. in different regimen: a) single dose (700 mg/kg) 10 h before the first dose of morphine, b) single dose (700 mg/kg) 10 h after the last dose of morphine, c) multiple doses (350 mg/kg) along with morphine twice a day for 7 days.
        
        
          Result
          Administration of Delphinium denudatum extract caused significant reduction in the frequency of counted signs as well as the presence of checked signs of morphine withdrawal. The maximum reduction was observed in regimen 'b' followed by regimen 'c' and 'a'.
        
        
          Conclusion
          Delphinium denudatum Wall. significantly reduces the aggregate scores for all parameters in morphine withdrawal syndrome by central action and thus may prove to be an alternative remedy in morphine de-addiction.
Compound 527359: 18,22,26-Trimethyl-hentriacontyl cyanide

Chemical compound data from PubChem database. IUPAC Name: 19,23,27-trimethyldotriacontanenitrile. Molecular Formula: C35H69N. Molecular Weight: 503.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Patent AT-E400404-T1: [Translated] METHOD AND DEVICE FOR AUTOMATIC PREPARATION FOR MOUNTING AN OPTHALMIC LENS

The method includes: automatic measurement of the marking characteristics of the lens in a measurement position in order to produce a marking reference of the ophthalmic lens; transfer of the lens in a second transfer movement from the measurement position to an intermediate position which is distinct from the measurement position; transfer of the lens in a third transfer movement from the intermediate position to a trimming position which is distinct from the intermediate position; locking of the ophthalmic lens on trimming elements (6); trimming the lens. The third transfer is carried out by third transfer elements that make up a sub-unit which is distinct and independent from other units or includes elements carrying out the second transfer, and trimming elements, wherein full blocking of the lens on the trimming elements is only completed after the third transfer.
Ambulance Patient Offload Times

<strong>A. SUMMARY</strong>
This dataset includes aggregated metrics of ambulance patient offload time for ambulance transports to San Francisco hospitals. 

<strong>B. HOW THE DATASET IS CREATED</strong>
This dataset contains aggregated data by hospital and month for two metrics: 90th percentile of ambulance patient offload time (APOT) and number of patients by discrete APOT category. The dataset also includes systemwide data for both metrics. <a href="https://leginfo.legislature.ca.gov/faces/codes_displaySection.xhtml?lawCode=HSC&sectionNum=1797.120.5.">APOT is defined</a> as the interval between the arrival of an ambulance patient at an emergency department and the time that the patient is transferred to an emergency department gurney, bed, chair, or other acceptable location and the emergency department assumes responsibility for care of the patient.

<strong>C. UPDATE PROCESS</strong>
The data is updated monthly by San Francisco Emergency Medical Services Agency.

<strong>D. HOW TO USE THIS DATASET</strong>
This dataset is based on EMS patient care reports received from a state database. Please note that you must first filter by Hospital_full and Metric_unit before aggregating the Value field.
2010 State Profile — Indiana

This state profile includes data from facilities in Indiana that reported to N-SSATS for the survey reference date March 31, 2010. Data were collected on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse treatment facilities (both public and private) in Indiana. In Indiana, 273 substance abuse treatment facilities were included in the 2010 N-SSATS, reporting that there were 24,500 clients in substance abuse treatment on March 31, 2010. The survey response rate in Indiana was 87.3%.
2011 CMHS Uniform Reporting System (URS) Output Tables for Louisiana

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2011. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
Compound 528550: Naphthalene, decahydro-, 2,2'-bis

Chemical compound data from PubChem database. IUPAC Name: 2-(1,2,3,4,4a,5,6,7,8,8a-decahydronaphthalen-2-yl)-1,2,3,4,4a,5,6,7,8,8a-decahydronaphthalene. Molecular Formula: C20H34. Molecular Weight: 274.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
What kind of evidence is it that Evidence-Based Medicine advocates want health care providers and consumers to pay attention to?

Background
          In 1992, Evidence-Based Medicine advocates proclaimed a "new paradigm", in which evidence from health care research is the best basis for decisions for individual patients and health systems. Hailed in New York Times Magazine in 2001 as one of the most influential ideas of the year, this approach was initially and provocatively pitted against the traditional teaching of medicine, in which the key elements of knowing for clinical purposes are understanding of basic pathophysiologic mechanisms of disease coupled with clinical experience. This paper reviews the origins, aspirations, philosophical limitations, and practical challenges of evidence-based medicine.
        
        
          Discussion
          EBM has long since evolved beyond its initial (mis)conception, that EBM might replace traditional medicine. EBM is now attempting to augment rather than replace individual clinical experience and understanding of basic disease mechanisms. EBM must continue to evolve, however, to address a number of issues including scientific underpinnings, moral stance and consequences, and practical matters of dissemination and application. For example, accelerating the transfer of research findings into clinical practice is often based on incomplete evidence from selected groups of people, who experience a marginal benefit from an expensive technology, raising issues of the generalizability of the findings, and increasing problems with how many and who can afford the new innovations in care.
        
        
          Summary
          Advocates of evidence-based medicine want clinicians and consumers to pay attention to the best findings from health care research that are both valid and ready for clinical application. Much remains to be done to reach this goal.
Patent AT-E401606-T1: [Translated] SEMICONDUCTOR COMPONENT WITH MULTIPLE MEMORY STRUCTURES

A structure and associated method of transfer data on a semiconductor device, comprising: a plurality of systems within the semiconductor device. Each system comprises at least one processing device and a local memory structure. Each processing device is electrically coupled to each local memory structure within each system. Each local memory structure is electrically coupled to each of the other said local memory structures. Each local memory structure is adapted to share address space with each of the processing devices. Each processing device is adapted to transmit data and instructions to each local memory structure.
Compound 529983: Cyclohexene, 5-ethenyl-1,5-dimethyl

Chemical compound data from PubChem database. IUPAC Name: 5-ethenyl-1,5-dimethylcyclohexene. Molecular Formula: C10H16. Molecular Weight: 136.23. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Abnormal expression of p27kip1 protein in levator ani muscle of aging women with pelvic floor disorders – a relationship to the cellular differentiation and degeneration

Background
          Pelvic floor disorders affect almost 50% of aging women. An important role in the pelvic floor support belongs to the levator ani muscle. The p27/kip1 (p27) protein, multifunctional cyclin-dependent kinase inhibitor, shows changing expression in differentiating skeletal muscle cells during development, and relatively high levels of p27 RNA were detected in the normal human skeletal muscles.
        
        
          Methods
          Biopsy samples of levator ani muscle were obtained from 22 symptomatic patients with stress urinary incontinence, pelvic organ prolapse, and overlaps (age range 38–74), and nine asymptomatic women (age 31–49). Cryostat sections were investigated for p27 protein expression and type I (slow twitch) and type II (fast twitch) fibers.
        
        
          Results
          All fibers exhibited strong plasma membrane (and nuclear) p27 protein expression. cytoplasmic p27 expression was virtually absent in asymptomatic women. In perimenopausal symptomatic patients (ages 38–55), muscle fibers showed hypertrophy and moderate cytoplasmic p27 staining accompanied by diminution of type II fibers. Older symptomatic patients (ages 57–74) showed cytoplasmic p27 overexpression accompanied by shrinking, cytoplasmic vacuolization and fragmentation of muscle cells. The plasma membrane and cytoplasmic p27 expression was not unique to the muscle cells. Under certain circumstances, it was also detected in other cell types (epithelium of ectocervix and luteal cells).
        
        
          Conclusions
          This is the first report on the unusual (plasma membrane and cytoplasmic) expression of p27 protein in normal and abnormal human striated muscle cells in vivo. Our data indicate that pelvic floor disorders are in perimenopausal patients associated with an appearance of moderate cytoplasmic p27 expression, accompanying hypertrophy and transition of type II into type I fibers. The patients in advanced postmenopause show shrinking and fragmentation of muscle fibers associated with strong cytoplasmic p27 expression.
Kinesin-like protein CENP-E is upregulated in rheumatoid synovial fibroblasts

Our aim was to identify specifically expressed genes using RNA arbitrarily primed (RAP)-polymerase chain reaction (PCR) for differential display in patients with rheumatoid arthritis (RA). In RA, amplification of a distinct PCR product suitable for sequencing could be observed. Sequence analysis identified the PCR product as highly homologous to a 434 base pair segment of the human centromere kinesin-like protein CENP-E. Differential expression of CENP-E was confirmed by quantitative reverse transcription PCR, immunohistochemistry and in situ hybridization. CENP-E expression was independent from prednisolone and could not be completely inhibited by serum starvation. RAP-PCR is a suitable method to identify differentially expressed genes in rheumatoid synovial fibroblasts. Also, because motifs of CENP-E show homologies to jun and fos oncogene products and are involved in virus assembly, CENP-E may be involved in the pathophysiology of RA.
Patent AT-E401517-T1: [Translated] SHUT-OFF VALVE

The invention relates to a shut-off fitting comprising a housing which is connected to an adjacent pipeline in a pressure tight manner, the diameter of said pipeline defining a tubular passage in the housing. Said fitting also comprises at least one closing body which can be displaced between an open position and a closed position. The inventive shut-off fitting is characterized in that the at least one closing body can be displaced by an articulated mechanism, by means of an actuator which can be vertically displaced in relation to the flow direction, in such a way that it is arranged outside the tubular passage in its open position. The closing body has a contour which is adapted to the contour of the tubular passage, in the open position, and is located on the tubular passage in a radially sealing manner.
The use of CAM by women suffering from nausea and vomiting during pregnancy

Background
          Nausea and vomiting during pregnancy (NVP) affects two-thirds of pregnant women to varying degrees and over the years many modalities have been used to try to alleviate this often debilitating condition. There is a paucity of information in the literature about the use or efficacy of complementary and alternative medicine (CAM) for the treatment of this condition that affects so many women. Our primary objective was to examine the prevalence of CAM usage by women suffering from NVP. Our secondary objective was to ascertain if women had any supervision in the use of these treatments.
        
        
          Methods
          Women who called The Motherisk NVP helpline, were asked after the counseling session to complete a questionnaire, which included demographic data as well as information about their CAM use.
        
        
          Results
          Seventy women completed the questionnaire. 61% reported using CAM therapies, of which the three most popular were: ginger, vitamin B6 and acupressure. 21% of those who reported using CAM, had consulted CAM practitioners, 8% their physicians or pharmacists and 71% discussed the usage with family, friends and other allied health professionals. Women who did not use CAM stated they would probably use these modalities if there was more information about the safety in pregnancy.
        
        
          Conclusion
          Pregnant women with NVP are mirroring the trend in the general population of the use of CAM. They are also using CAM therapies with little supervision from practitioners experienced in the use of these modalities.
Elk Creek Seismic Waveforms 2012 (Part 17 of 20)

Coal bursts (damaging seismic events in underground coal mines) pose a substantial threat to operations and mine workers. The underground coal mines in Colorado’s North Fork Valley (NFV) have experienced many coal bursts, often with distinct characteristics from those of other US coal mining regions. To better understand these events and manage their associated risks, the National Institute for Occupational Safety and Health undertook a long-term monitoring campaign at the Elk Creek Mine in the NFV. The monitoring efforts included a seismic network composed of both surface and underground sensors, borehole pressure cells (BPCs), instrumented support Cans, convergence monitors, ground condition surveys, and several other data sources. This dataset consists of the event waveform files from the seismic network for the 983,379 events that were detected during the monitoring campaign. The waveforms are stored in HDF5 files that are broken up by week. Within the HDF5 files, the data are organized by station id, event time, and channel. The amplitudes are velocity in meters/second.
 
This is download 44 of 48 and corresponds to the time range between November 5, 2012, and November 12, 2012.
Aminoadipate reductase gene: a new fungal-specific gene for comparative evolutionary analyses

Background
          In fungi, aminoadipate reductase converts 2-aminoadipate to 2-aminoadipate 6-semialdehyde. However, other organisms have no homologue to the aminoadipate reductase gene and this pathway appears to be restricted to fungi. In this study, we designed degenerate primers for polymerase chain reaction (PCR) amplification of a large fragment of the aminoadipate reductase gene for divergent fungi.
        
        
          Results
          Using these primers, we amplified DNA fragments from the archiascomycetous yeast Saitoella complicata and the black-koji mold Aspergillus awamori. Based on an alignment of the deduced amino acid sequences, we constructed phylogenetic trees. These trees are consistent with current ascomycete systematics and demonstrate the potential utility of the aminoadipete reductase gene for phylogenetic analyses of fungi.
        
        
          Conclusions
          We believe that the comparison of aminoadipate reductase among species will be useful for molecular ecological and evolutionary studies of fungi, because this enzyme-encoding gene is a fungal-specific gene and generally appears to be single copy.
Patent AT-E400761-T1: [Translated] SUPPORT DEVICE FOR TECHNOLOGICAL SYSTEM FOR WALLS

A support device of technological systems for walls, provided with at least a layer of plates (2), includes: first section bar means (3), having an elongated shape, each one including a first element (4) with "C" cross section whose edges have respective folded borders, first (5) and second (6), defining a longitudinal opening (10) of section bar means (3); fixing means (7) each one provided with at least first lip means (8) and first blocking means (9). In an assemblage condition (M) of device (1), the first section bar means (3) are fit for containing and supporting connection elements (50) of the system by means of respective first elements (4) and the second folded border (6) supports the plates (2) of the wall layer. The first lip means (8) of fixing means (7) are interposed between the first folded border (5) and said plates (2) and the first blocking means (9) are fit for fixing interconnection elements (51) of technological system to respective openings of the wall layer and to longitudinal openings (10) of the first section bar means (3).
Compound 528596: Bis(dimethyl-t-butylsilyl) succinate

Chemical compound data from PubChem database. IUPAC Name: bis[tert-butyl(dimethyl)silyl] butanedioate. Molecular Formula: C16H34O4Si2. Molecular Weight: 346.61. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Investigating the mechanism of acoustically activated uptake of drugs from Pluronic micelles

Background
          This paper examines the mechanism of ultrasonic enhanced drug delivery from Pluronic micelles. In previous publications by our group, fluorescently labeled Pluronic was shown to penetrate HL-60 cells with and without the action of ultrasound, while drug uptake was increased with the application of ultrasound.
        
        
          Methods
          In this study, the amount of uptake of two fluorescent probes, Lysosensor Green (a pH-sensitive probe) and Cell Tracker Orange CMTMR (a pH-independent probe), was measured in HL-60 and HeLa cells.
        
        
          Results
          The results of our experiments show that the increase in drug accumulation in the cells as a result of ultrasonication is not due to an increase in endocytosis due to ultrasonication.
        
        
          Conclusions
          We hypothesize that sonoporation plays an important role in the acoustically activated drug delivery of chemotherapy drugs delivered from Pluronic micelles.
Compound 528452: 1-Hexadecene, 7,11,15-trimethyl

Chemical compound data from PubChem database. IUPAC Name: 7,11,15-trimethylhexadec-1-ene. Molecular Formula: C19H38. Molecular Weight: 266.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Potentially Avoidable Antibiotic Prescribing Rates for Acute Respiratory Infection by Provider County, Adults Age 18-64 Years, NYS Medicaid: Beginning 2010

This dataset contains Potentially Avoidable Antibiotic Prescribing observed and risk-adjusted rates for adult Medicaid enrollees by provider county beginning in 2010.

Potentially Avoidable Antibiotic Prescriptions are antibiotic prescriptions filled for the treatment of acute respiratory infections for which antibiotics are not indicated, contributing to bacterial drug resistance. Index visits for acute respiratory infections and corresponding prescription fills were identified through the use of previously published methods.   

The rates were calculated using Medicaid outpatient claims and encounters, and prescription drug data.  

The observed and risk adjusted rates are presented by provider county (including a statewide total).
Dimerization of Receptor Protein-Tyrosine Phosphatase alpha in living cells

Background
          Dimerization is an important regulatory mechanism of single membrane-spanning receptors. For instance, activation of receptor protein-tyrosine kinases (RPTKs) involves dimerization. Structural, functional and biochemical studies suggested that the enzymatic counterparts of RPTKs, the receptor protein-tyrosine phosphatases (RPTPs), are inhibited by dimerization, but whether RPTPs actually dimerize in living cells remained to be determined.
        
        
          Results
          In order to assess RPTP dimerization, we have assayed Fluorescence Resonance Energy Transfer (FRET) between chimeric proteins of cyan- and yellow-emitting derivatives of green fluorescent protein, fused to RPTPα, using three different techniques: dual wavelength excitation, spectral imaging and fluorescence lifetime imaging. All three techniques suggested that FRET occurred between RPTPα -CFP and -YFP fusion proteins, and thus that RPTPα dimerized in living cells. RPTPα dimerization was constitutive, extensive and specific. RPTPα dimerization was consistent with cross-linking experiments, using a non-cell-permeable chemical cross-linker. Using a panel of deletion mutants, we found that the transmembrane domain was required and sufficient for dimerization.
        
        
          Conclusions
          We demonstrate here that RPTPα dimerized constitutively in living cells, which may be mediated by the transmembrane domain, providing strong support for the model that dimerization is involved in regulation of RPTPs.
Publications Using SAMHSA DataBehavioral Health Barometer: Region 2, Volume 7

Explore state and regional data for HHS Region 2 with this user-friendly behavioral health report. It uses data from the 2021-2022 National Surveys on Drug Use and Health (NSDUH). The topics addressed in this report include substance use, substance use disorders, and mental health. Selected estimates are provided for adolescents aged 12 to 17, underage people aged 12 to 20, adults aged 18 or older, and the general population aged 12 or older. Statistical tests compare population percentages of (1) HHS region versus national estimates, (2) state versus national estimates, and (3) state versus HHS region estimates.
Patent AT-E399769-T1: [Translated] SYNTHESIS OF HISTAMINE DIHYDROCHLORIDE

The invention disclosed herein relates to the preparation of pharmaceutical grades of histamine dihydrochloride using a two step non-enzymatic synthetic method. The invention disclosed herein describes the synthesis of histamine dihydrochloride by the non-enzymatic decarboxylation of histidine and the step-wise conversion of the decarboxylated product to the dihydrochloride salt form. The invention disclosed herein considers a final product of histamine dihydrochloride containing less than each of the following: 0.8% <SMALLCAPS>L</SMALLCAPS>-histidine HCl monohydrate, 0.1% individual chromatographic impurities, and 2% total impurities, to be acceptable for pharmaceutical use.