AndreaBozzo/ceres-open-data-index huggingface dataset:
A genomic timescale for the origin of eukaryotes

Background
          Genomic sequence analyses have shown that horizontal gene transfer occurred during the origin of eukaryotes as a consequence of symbiosis. However, details of the timing and number of symbiotic events are unclear. A timescale for the early evolution of eukaryotes would help to better understand the relationship between these biological events and changes in Earth's environment, such as the rise in oxygen. We used refined methods of sequence alignment, site selection, and time estimation to address these questions with protein sequences from complete genomes of prokaryotes and eukaryotes.
        
        
          Results
          Eukaryotes were found to evolve faster than prokaryotes, with those eukaryotes derived from eubacteria evolving faster than those derived from archaebacteria. We found an early time of divergence (~4 billion years ago, Ga) for archaebacteria and the archaebacterial genes in eukaryotes. Our analyses support at least two horizontal gene transfer events in the origin of eukaryotes, at 2.7 Ga and 1.8 Ga. Time estimates for the origin of cyanobacteria (2.6 Ga) and the divergence of an early-branching eukaryote that lacks mitochondria (Giardia) (2.2 Ga) fall between those two events.
        
        
          Conclusions
          We find support for two symbiotic events in the origin of eukaryotes: one premitochondrial and a later mitochondrial event. The appearance of cyanobacteria immediately prior to the earliest undisputed evidence for the presence of oxygen (2.4–2.2 Ga) suggests that the innovation of oxygenic photosynthesis had a relatively rapid impact on the environment as it set the stage for further evolution of the eukaryotic cell.
Protective Factors Part 2

This Child Welfare Information Gateway Podcast is available on Apple Podcasts
  
  

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Metadata-only record linking to the original dataset. Open original dataset below.
Medicaid coverage among persons under age 65, by selected characteristics: United States

Data on Medicaid coverage among persons under age 65 by selected population characteristics. Please refer to the PDF or Excel version of this table in the HUS 2019 Data Finder (https://www.cdc.gov/nchs/hus/contents2019.htm) for critical information about measures, definitions, and changes over time. 

SOURCE: NCHS, National Health Interview Survey, health insurance supplements (1984, 1989, 1994-1996). Starting with 1997, data are from the family core and the sample adult questionnaires. Data for level of difficulty are from the 2010 Quality of Life, 2011-2017 Functioning and Disability, and 2018 Sample Adult questionnaires. For more information on the National Health Interview Survey, see the corresponding Appendix entry at https://www.cdc.gov/nchs/data/hus/hus19-appendix-508.pdf.
NNDSS - TABLE 1KK. Vancomycin-intermediate Staphylococcus aureus to Varicella morbidity

NNDSS - TABLE 1KK. Vancomycin-intermediate Staphylococcus aureus to Varicella morbidity – 2021. In this Table, provisional cases* of notifiable diseases are displayed for United States, U.S. territories, and Non-U.S. residents.

Notice: Due to data processing issues at CDC, data for the following jurisdictions may be incomplete for week 7: Alaska, Arizona, California, Connecticut, Delaware, Florida, Hawaii, Louisiana, Maryland, Michigan, Missouri, North Dakota, New Hampshire, New York City, Oregon, Pennsylvania, and Rhode Island.

Note: 
This table contains provisional cases of national notifiable diseases from the National Notifiable Diseases Surveillance System (NNDSS). NNDSS data from the 50 states, New York City, the District of Columbia and the U.S. territories are collated and published weekly on the NNDSS Data and Statistics web page (https://wwwn.cdc.gov/nndss/data-and-statistics.html). Cases reported by state health departments to CDC for weekly publication are provisional because of the time needed to complete case follow-up. Therefore, numbers presented in later weeks may reflect changes made to these counts as additional information becomes available. The national surveillance case definitions used to define a case are available on the NNDSS web site at https://wwwn.cdc.gov/nndss/. Information about the weekly provisional data and guides to interpreting data are available at: https://wwwn.cdc.gov/nndss/infectious-tables.html. 

Footnotes:
U: Unavailable — The reporting jurisdiction was unable to send the data to CDC or CDC was unable to process the data.
-: No reported cases — The reporting jurisdiction did not submit any cases to CDC.
N: Not reportable — The disease or condition was not reportable by law, statute, or regulation in the reporting jurisdiction.
NN: Not nationally notifiable — This condition was not designated as being nationally notifiable.
NP: Nationally notifiable but not published.
NC: Not calculated — There is insufficient data available to support the calculation of this statistic.
Cum: Cumulative year-to-date counts.
 Max: Maximum — Maximum case count during the previous 52 weeks.
  * Case counts for reporting years 2020 and 2021 are provisional and subject to change. Cases are assigned to the reporting jurisdiction submitting the case to NNDSS, if the case's country of usual residence is the U.S., a U.S. territory, unknown, or null (i.e. country not reported); otherwise, the case is assigned to the 'Non-U.S. Residents' category. Country of usual residence is currently not reported by all jurisdictions or for all conditions. For further information on interpretation of these data, see https://wwwn.cdc.gov/nndss/document/Users_guide_WONDER_tables_cleared_final.pdf. 
†Previous 52 week maximum and cumulative YTD are determined from periods of time when the condition was reportable in the jurisdiction (i.e., may be less than 52 weeks of data or incomplete YTD data).
National Survey on Drug Use and Health (NSDUH-2002)

<p>The National Survey on Drug Use and Health (NSDUH) series (formerly titled National Household Survey on Drug Abuse) measures the prevalence and correlates of drug use in the United States. The surveys are designed to provide quarterly, as well as annual, estimates. Information is provided on the use of illicit drugs, alcohol, and tobacco among members of United States households aged 12 and older. Questions include age at first use as well as lifetime, annual, and past-month usage for the following drug classes: marijuana, cocaine (and crack), hallucinogens, heroin, inhalants, alcohol, tobacco, and nonmedical use of prescription drugs, including pain relievers, tranquilizers, stimulants, and sedatives. The survey covers substance abuse treatment history and perceived need for treatment, and includes questions from the Diagnostic and Statistical Manual (DSM) of Mental Disorders that allow diagnostic criteria to be applied. The survey includes questions concerning treatment for both substance abuse and mental health related disorders. Respondents are also asked about personal and family income sources and amounts, health care access and coverage, illegal activities and arrest record, problems resulting from the use of drugs, and needle-sharing. Questions introduced in previous administrations were retained in the 2002 survey, including questions asked only of respondents aged 12 to 17. These "youth experiences" items covered a variety of topics, such as neighborhood environment, illegal activities, gang involvement, drug use by friends, social support, extracurricular activities, exposure to substance abuse prevention and education programs, and perceived adult attitudes toward drug use and activities such as school work. Several measures focused on prevention related themes in this section. Also retained were questions on mental health and access to care, perceived risk of using drugs, perceived availability of drugs, driving and personal behavior, and cigar smoking. Questions on the tobacco brand used most often were introduced with the 1999 survey and have been retained through the 2002 survey. Demographic data include sex, race, age, ethnicity, marital status, educational level, job status, veteran status, and current household composition. This study has 1 Data Set.</p>
Does lindane (gamma-hexachlorocyclohexane) increase the rapid delayed rectifier outward K

Background
          The effects of lindane, a gamma-isomer of hexachlorocyclohexane, were studied on transmembrane potentials and currents of frog atrial heart muscle using intracellular microelectrodes and the whole cell voltage-clamp technique.
        
        
          Results
          Lindane (0.34 microM to 6.8 microM) dose-dependently shortened the action potential duration (APD). Under voltage-clamp conditions, lindane (1.7 microM) increased the amplitude of the outward current (Iout) which developed in Ringer solution containing TTX (0.6 microM), Cd2+ (1 mM) and TEA (10 mM). The lindane-increased Iout was not sensitive to Sr2+ (5 mM). It was blocked by subsequent addition of quinidine (0.5 mM) or E-4031 (1 microM). E-4031 lengthened the APD; it prevented or blocked the lindane-induced APD shortening.
        
        
          Conclusions
          In conclusion, our data revealed that lindane increased the quinidine and E-4031-sensitive rapid delayed outward K+ current which contributed to the AP repolarization in frog atrial muscle.
2015 CMHS Uniform Reporting System (URS) Table for New Jersey

2015 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for New Jersey.  The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.
National Admissions to Substance Abuse Treatment Services The Treatment Episode Data Set (TEDS) 1992-2000

This report presents results from the Treatment Episode Data Set (TEDS) for 2000 and trend data for 1992-2000. The report provides information on the demographic and substance abuse characteristics of the approximately 1.6 million people admitted to treatment for abuse of alcohol and drugs in 2000 to facilities that report to individual state administrative data systems.
Behavioral Health Barometer: United States, 2013

This is a behavioral health report for the United States. The report utilizes data from the National Survey on Drug Use and Health (NSDUH), the Youth and Risk Behavior Survey (YRBS), the Monitoring of the Future Survey sponsored by the National Institute on Drug Abuse and findings by the Center for Medicare & Medicaid Services about the use of of mental health and substance use treatment services by medicare recipients. The topics address in the report include youth substance use, youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment, and medicare enrollees for the years 2008 to 2012.
Patent AT-E400700-T1: [Translated] DEVICE FOR ATTACHING AND/OR REMOVAL OF RAIL CLAMPS

A device (1) for the application and/or for the removal of elements for the connection of a rail to a railway track sleeper, comprising at least one lever (2, 3) mounted on a frame (4) in a rotatable manner around an axis of rotation (5, 6), and equipped with at least one pressure organ (7, 8) adapted to engaging the connecting element, and at least one cylinder-piston group (9) adapted to driving the lever (2, 3) in order to assemble or disassemble the connecting element. The cylinder-piston group (9) comprises a cylinder body (10) and a sliding piston (11) housed within the cylinder body (10) and moveable with respect to the cylinder body (10) under the action of pressurised fluid. At least one first (12, 14) and second (13, 15) stop surfaces interact in such a manner as to form a stop device (16, 17) for stopping the lever (2, 3) in a defined position with respect to the frame (4), wherein the stop surfaces are formed, the one (12, 14) on the piston (11) and the other (13, 15) on the cylinder body (10) of said cylinder-piston group (9).
Multiple redundant sequence elements within the fission yeast

Background
          Some origins in eukaryotic chromosomes fire more frequently than others. In the fission yeast, Schizosaccharomyces pombe, the relative firing frequencies of the three origins clustered 4-8 kbp upstream of the ura4 gene are controlled by a replication enhancer - an element that stimulates nearby origins in a relatively position-and orientation-independent fashion. The important sequence motifs within this enhancer were not previously localized.
        
        
          Results
          Systematic deletion of consecutive segments of ~50, ~100 or ~150 bp within the enhancer and its adjacent core origin (ars3002) revealed that several of the ~50-bp stretches within the enhancer contribute to its function in partially redundant fashion. Other stretches within the enhancer are inhibitory. Some of the stretches within the enhancer proved to be redundant with sequences within core ars3002. Consequently the collection of sequences important for core origin function was found to depend on whether the core origin is assayed in the presence or absence of the enhancer. Some of the important sequences in the core origin and enhancer co-localize with short runs of adenines or thymines, which may serve as binding sites for the fission yeast Origin Recognition Complex (ORC). Others co-localize with matches to consensus sequences commonly found in fission yeast replication origins.
        
        
          Conclusions
          The enhancer within the ura4 origin cluster in fission yeast contains multiple sequence motifs. Many of these stimulate origin function in partially redundant fashion. Some of them resemble motifs also found in core origins. The next step is to identify the proteins that bind to these stimulatory sequences.
Patent AT-E400097-T1: [Translated] WIRELESS COMMUNICATION WITH TRANSMIT DIVERSITY

A method of transmitting data from a transmitter (13, 24) to a remote receiver (14, 28) using transmit diversity wireless communication, the transmitter (13, 24) comprising a plurality of transmit antenna elements (1, 2, 3, 4). The data is encoded in symbol blocks (12), the symbols (s1, s2, s3, s4) of a block (12) being permuted between the transmit antenna elements (1, 2, 3, 4) over time with respective replications and complex conjugations and/or negations. The transmitter (13, 24) comprises at least three of said transmit antenna elements (1, 2, 3, 4) and the signals transmitted over at least one of the transmit antenna elements (1, 2, 3, 4) are modified as a function of channel information at least approximately related to the channel transfer function (h1, h2, h 3, and h4) of the transmitted signals, so that the received signal is detectable at the receiver (14, 28) using an orthogonal detection matrix scheme. <IMAGE>
Research Article: BMC Cancer

Background
          We previously reported that the α-1 chain of type 11 collagen (COL11A1), not normally expressed in the colon, was up-regulated in stromal fibroblasts in most sporadic colorectal carcinomas. Patients with germline mutations in the APC gene show, besides colonic polyposis, symptoms of stromal fibroblast involvement, which could be related to COL11A1 expression. Most colorectal carcinomas are suggested to be a result of an activated Wnt- pathway, most often involving an inactivation of the APC gene or activation of β-catenin.
        
        
          Methods
          We used normal and polyp tissue samples from one FAP patient and a set of 37 sporadic colorectal carcinomas to find out if the up-regulation of COL11A1 was associated with an active APC/β-catenin pathway.
        
        
          Results
          In this study we found a statistically significant difference in COL11A1 expression between normal tissue and adenomas from one FAP patient, and all adenomas gave evidence for an active APC/β-catenin pathway. An active Wnt pathway has been suggested to involve stromal expression of WISP-1. We found a strong correlation between WISP-1 and COL11A1 expression in sporadic carcinomas.
        
        
          Conclusions
          Our results suggest that expression of COL11A1 in colorectal tumors could be associated with the APC/β-catenin pathway in FAP and sporadic colorectal cancer.
U.S. State and Territorial Public Mask Mandates From April 10, 2020 through July 20, 2021 by County by Day

State and territorial executive orders, administrative orders, resolutions, and proclamations are collected from government websites and cataloged and coded using Microsoft Excel by one coder with one or more additional coders conducting quality assurance.

Data were collected to determine when members of the public in states and territories were subject to state and territorial executive orders, administrative orders, resolutions, and proclamations for COVID-19 that require them to wear masks in public. “Members of the public” are defined as individuals operating in a personal capacity. “In public” is defined to mean either (1) anywhere outside the home or (2) both in retail businesses and in restaurants/food establishments. Data consists exclusively of state and territorial orders, many of which apply to specific counties within their respective state or territory; therefore, data is broken down to the county level. 

These data are derived from publicly available state and territorial executive orders, administrative orders, resolutions, and proclamations (“orders”) for COVID-19 that expressly require individuals to wear masks in public found by the CDC, COVID-19 Community Intervention & Critical Populations Task Force, Monitoring & Evaluation Team, Mitigation Policy Analysis Unit, Center for State, Tribal, Local, and Territorial Support, Public Health Law Program, and Max Gakh, Assistant Professor, School of Public Health, University of Nevada, Las Vegas from April 10, 2020 through July 20, 2021.  These data will be updated as new orders are collected. Any orders not available through publicly accessible websites are not included in these data. Only official copies of the documents or, where official copies were unavailable, official press releases from government websites describing requirements were coded; news media reports on restrictions were excluded. Recommendations not included in an order are not included in these data. Effective and expiration dates were coded using only the dates provided; no distinction was made based on the specific time of the day the order became effective or expired. These data do not include data on counties that have opted out of their state mask mandate pursuant to state law. These data do not necessarily represent an official position of the Centers for Disease Control and Prevention.
Patent AT-E400621-T1: [Translated] INKJET INK SET, RECORDING METHOD AND IMAGE RECORDED THEREFROM

Disclosed is an ink jet recording ink set having light color inks of a plurality of colors and dark color inks of a plurality of colors. Each of the light color inks has at least a pigment, a solvent and a fine polymer particle and each of the dark color inks having at least a pigment and a solvent. Furthermore, each of the dark color inks either do not contain a fine polymer particle or contain a fine polymer particle in smaller quantity than the light color inks.
Avapritinib

Ayvakit (avapritinib) is a prescription oral tablet medication manufactured by Blueprint Medicines Corporation. It acts as a kinase inhibitor, specifically targeting tyrosine kinases, and is used to treat certain cancers like gastrointestinal stromal tumors and systemic mastocytosis. Available in strengths of 25mg, 50mg, 100mg, 200mg, and 300mg. This information was generated using AI and is provided for informational and research purposes only.
Compound 525572: N,N-Dimethyl-N'-(3-ethoxyphenyl)-p-methylbenzamidine

Chemical compound data from PubChem database. IUPAC Name: N'-(3-ethoxyphenyl)-N,N,4-trimethylbenzenecarboximidamide. Molecular Formula: C18H22N2O. Molecular Weight: 282.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
State Child Welfare (SCW) Data Linkages Descriptive Study

The State Child Welfare Data Linkages (SCW) Descriptive Study aims to provide novel information regarding connected (linked or integrated) state data that may be leveraged to improve the ongoing and accurate surveillance of child maltreatment incidence and related risk. The study examined the extent to which child welfare agencies in 50 states, Puerto Rico, and Washington, DC connected administrative data on child maltreatment to other data sources and aimed to learn more about agency practices related to sharing and connecting data. 
The SCW Descriptive Study explored the following research questions:

Investigators: Bradley, M. C., Lee, J., Page, J., Strelevitz, T., & Sutton-Heisey, R.
Compound 527828: His, 1-methyl, butyl ester

Chemical compound data from PubChem database. IUPAC Name: butyl 2-amino-3-(1-methylimidazol-4-yl)propanoate. Molecular Formula: C11H19N3O2. Molecular Weight: 225.29. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Methylprednisolone sodium succinate

Methylprednisolone Sodium Succinate is a corticosteroid medication available as an injectable powder for solution. It helps reduce inflammation, swelling, and immune responses in conditions like arthritis, allergies, and certain diseases. Administered by intramuscular or intravenous injection in strengths from 40 mg to 2 g per vial. Manufactured by Eugia US LLC under ANDA207667. This information was generated using AI and is provided for informational and research purposes only.
Compound 525478: 4-Methyl-3,5-dithia-7-octene

Chemical compound data from PubChem database. IUPAC Name: 3-(1-ethylsulfanylethylsulfanyl)prop-1-ene. Molecular Formula: C7H14S2. Molecular Weight: 162.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528897: 2-Ethyl-2-(4-hydroxyphenyl)glutarimide

Chemical compound data from PubChem database. IUPAC Name: 3-ethyl-3-(4-hydroxyphenyl)piperidine-2,6-dione. Molecular Formula: C13H15NO3. Molecular Weight: 233.26. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.